Optimal Component Lumping: problem formulation and solution techniques
DEFF Research Database (Denmark)
Lin, Bao; Leibovici, Claude F.; Jørgensen, Sten Bay
2008-01-01
This paper presents a systematic method for optimal lumping of a large number of components in order to minimize the loss of information. In principle, a rigorous composition-based model is preferable to describe a system accurately. However, computational intensity and numerical issues restrict...... such applications in process modeling, simulation and design. A pseudo-component approach that lumps a large number of components in a system into a much smaller number of hypothetical groups reduces the dimensionality at the cost of losing information. Moreover, empirical and heuristic approaches are commonly used...... significantly reduces the number of independent variables. The application to a system with 144 components demonstrates that the optimal lumping problem can be efficiently solved with a stochastic optimization method, Tabu Search (TS) algorithm. The case study also reveals that the discrete formulation...
Directory of Open Access Journals (Sweden)
Iran E. Lima Neto
2006-06-01
Full Text Available Nesta pesquisa, desenvolveu-se uma solução analítica para previsão e análise do desempenho de injetores de fertilizantes. As equações de conservação de massa, quantidade de movimento e energia, foram aplicadas ao processo de mistura dos fluidos de sucção e motriz através de uma formulação adimensional. Injetores de alto desempenho foram avaliados experimentalmente, utilizando-se água, tanto como fluido motriz como de sucção, de forma que os coeficientes de perda de carga em cada componente desses equipamentos, fossem obtidos através de calibração. A formulação proposta apresentou estreita concordância com os dados experimentais e forneceu valores adequados para os coeficientes de perda de carga implícitos nas equações. Através de curvas teóricas de rendimento, geradas a partir dos coeficientes de perda de carga calibrados, constatou-se que, quanto maior é a densidade do fluido de sucção menores são as faixas de vazão de operação e os rendimentos alcançados.An analytical solution was developed in this research to predict and evaluate the performance of fertilizer injectors. The conservation equations for mass, momentum and energy were applied to the mixing process between the driving and suction fluids through a dimensionless formulation. High performance injectors were evaluated experimentally using water both as driving and suction fluids in order to determine the head-loss coefficients for each component of these accessories through calibration. The proposed solution presented excellent agreement with the experimental data and achieved adequate values for the implicit head-loss coefficients in the equations. Theoretical efficiency curves generated on the basis of these coefficients showed that the higher the density of the suction fluid, the lower the ranges of flow ratio and efficiencies reached.
International Nuclear Information System (INIS)
Su, Jian; Cotta, Renato M.
2000-01-01
In this work, thermohydraulic behaviour of PWR, during reactivity insertion and partial loss-of-flow, is simulated by using a simplified mathematical model of reactor core and primary coolant. An improved lumped parameter formulation for transient heat conduction in fuel rod is used for core heat transfer modelling. Transient temperature response of fuel, cladding and coolant is analysed. (author)
Daniele, C. J.; Lorenzo, C. F.
1979-01-01
Lumped volume dynamic equations are derived using an energy-state formulation. This technique requires that kinetic and potential energy state functions be written for the physical system being investigated. To account for losses in the system, a Rayleigh dissipation function is also formed. Using these functions, a Lagrangian is formed and using Lagrange's equation, the equations of motion for the system are derived. The results of the application of this technique to a lumped volume are used to derive a model for the free-piston Stirling engine. The model was simplified and programmed on an analog computer. Results are given comparing the model response with experimental data.
Energy Technology Data Exchange (ETDEWEB)
Ibsen, Lars Bo; Liingaard, M.
2006-12-15
A lumped-parameter model represents the frequency dependent soil-structure interaction of a massless foundation placed on or embedded into an unbounded soil domain. In this technical report the steps of establishing a lumped-parameter model are presented. Following sections are included in this report: Static and dynamic formulation, Simple lumped-parameter models and Advanced lumped-parameter models. (au)
Energy Technology Data Exchange (ETDEWEB)
Kurokawa, Sergio; Yamanaka, Fabio N.R.; Prado, Afonso J. [Faculdade de Engenharia de Ilha Solteira, Avenida Brasil Centro 56, Caixa Postal 31, Ilha Solteira, SP, CEP 15385-000 (Brazil); Pissolato, Jose [Universidade Estadual de Campinas, Caixa Postal 6101, CEP 13081-970, Campinas, SP (Brazil)
2009-07-15
The objective of this paper is to include the frequency dependence of the longitudinal parameters in the lumped parameters line model. The distributed nature of the transmission line was approximated by a cascade of {pi} circuits and the frequency effect was approximated by a rational function which was synthesized by an equivalent circuit. Then, the equivalent circuit was inserted in each {pi} circuit of the cascade. After that, the currents and voltages along the line were described in the form of state equations. This way, it was possible to obtain a formation rule of the state matrices lumped parameters model taking into account the frequency dependence. To confirm the validation of the state matrices obtained, the lumped parameters representation of frequency-dependent lines was used to represent a single-phase line and a three-phase line. The simulations were carried out using state space techniques and an electromagnetic transient program (EMTP) (in this case, the cascade was inserted in the EMTP). It is observed that the simulation results obtained with state space representation are in agreement with those results obtained with EMTP. (author)
Czech Academy of Sciences Publication Activity Database
Růžička, Marek
2008-01-01
Roč. 86, č. 8A (2008), s. 835-868 ISSN 0263-8762 R&D Projects: GA ČR GA104/06/1418; GA ČR GA104/07/1110; GA AV ČR IAAX00130702; GA AV ČR(CZ) IAA200720801; GA MŠk ME 952 Institutional research plan: CEZ:AV0Z40720504 Keywords : dimensionless numbers * dimensional analysis * scaling of equation s Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 0.989, year: 2008
Abdominal hernia; Hernia - abdominal; Abdominal wall defects; Lump in the abdominal wall; Abdominal wall mass ... lump in the abdomen is caused by a hernia. An abdominal hernia occurs when there is a weak spot ...
Lumped Thermal Household Model
DEFF Research Database (Denmark)
Biegel, Benjamin; Andersen, Palle; Stoustrup, Jakob
2013-01-01
a lumped model approach as an alternative to the individual models. In the lumped model, the portfolio is seen as baseline consumption superimposed with an ideal storage of limited power and energy capacity. The benefit of such a lumped model is that the computational effort of flexibility optimization...
Directory of Open Access Journals (Sweden)
R S Bhandari
2010-06-01
Full Text Available INTRODUCTION: Appendicular lump is a well known sequalae of acute appendicitis encountered in 2-6% of patients. Successful management of appendicular lump is controversial with different approaches. As many controversies are arising regarding management of appendicular lump. The aim of this study was to find out the outcome and evaluate possible need of changing our management strategy of appendicular lump. METHODS: A retrospective analysis of the patients managed with appendicular lump were done. All the patients admitted with diagnosis of appendicular lump and managed between, over two and half years, were included in the study. All age groups and both sex were included. Any patients whose diagnosis was changed after initial diagnosis of appendicular lump were excluded from the study. RESULTS: Total 75 patients had appendicular lump suggesting 10% incidence. Age varied between 11-83 years with nearly equal incidence in both sexes. Majority had onset of symptoms between 2 to 14 days with an average of 4 days. Average stay was 3 to 4 days. During study period, 12 (16% came with recurrence and 13 (17% cases came for elective appendectomy. CONCLUSIONS: Based on our finding, it is not sufficient to change our classical management strategy of appendicular lump and suggests a need for long term prospective study in this very common clinical condition. KEYWORDS: appendicular lump, conservative management.
Dimensionless Analysis Applied to Bacterial Chemotaxis towards NAPL Contaminants
Wang, X.; GAO, B.; Zhong, W.; Kihaule, K. S.; Ford, R.
2017-12-01
The use of chemotactic bacteria in bioremediation may improve the efficiency and decrease the cost of restoration, which means it has the potential to address environmental problems caused by oil spills. However, most previous studies were focused at the laboratory-scale and there lacks a formalism that can use these laboratory-scale results as input to evaluate the relative importance of chemotaxis at the field scale. In this study, a dimensionless equation is formulated to solve this problem. First, the main influential factors were extracted based on previous researches in environmental bioremediation and then five sets of dimensionless numbers were obtained according to Buckingham theory. After collecting basic parameter values and supplementary calculations to determine the concentration gradient of the chemoattractant, all dimensionless numbers were calculated and categorized into two types, those that were sensitive to chemotaxis or those to groundwater velocity. The bacteria ratio (BR), defined as the ratio of maximum bacteria concentration to its original value, was correlated with a combination of dimensionless numbers to yield, BR=cP1-0.085P20.329P30.1P4-0.098. For a bacterial ratio greater than one, the bioremediation strategy based on chemotaxis is expected to be effective, and chemotactic bacteria are expected to accumulate around NAPL contaminant sources efficiently.
Bhandari, R S; Thakur, D K; Lakhey, P J; Singh, K P
2010-01-01
Appendicular lump is a well known sequalae of acute appendicitis encountered in 2-6% of patients. Successful management of appendicular lump is controversial with different approaches. As many controversies are arising regarding management of appendicular lump. The aim of this study was to find out the outcome and evaluate possible need of changing our management strategy of appendicular lump. A retrospective analysis of the patients managed with appendicular lump were done. All the patients admitted with diagnosis of appendicular lump and managed between, over two and half years, were included in the study. All age groups and both sex were included. Any patients whose diagnosis was changed after initial diagnosis of appendicular lump were excluded from the study. Total 75 patients had appendicular lump suggesting 10% incidence. Age varied between 11-83 years with nearly equal incidence in both sexes. Majority had onset of symptoms between 2 to 14 days with an average of 4 days. Average stay was 3 to 4 days. During study period, 12 (16%) came with recurrence and 13 (17%) cases came for elective appendectomy. Based on our finding, it is not sufficient to change our classical management strategy of appendicular lump and suggests a need for long term prospective study in this very common clinical condition.
Causes of breast lumps (image)
... breast lumps are benign (non-cancerous), as in fibroadenoma, a condition that mostly affects women under age ... with the menstrual cycle, whereas a lump from fibroadenoma does not. While most breast lumps are benign, ...
Brochot, Céline; Tóth, János; Bois, Frédéric Y
2005-12-01
Pharmacokinetic (PK) models simplify biological complexity by dividing the body into interconnected compartments. The time course of the chemical's amount (or concentration) in each compartment is then expressed as a system of ordinary differential equations. The complexity of the resulting system of equations can rapidly increase if a precise description of the organism is needed. However, difficulties arise when the PK model contains more variables and parameters than comfortable for mathematical and computational treatment. To overcome such difficulties, mathematical lumping methods are new and powerful tools. Such methods aim at reducing a differential system by aggregating several variables into one. Typically, the lumped model is still a differential equation system, whose variables are interpretable in terms of variables of the original system. In practice, the reduced model is usually required to satisfy some constraints. For example, it may be necessary to keep state variables of interest for prediction unlumped. To accommodate such constraints, constrained lumping methods have are also available. After presenting the theory, we study, here, through practical examples, the potential of such methods in toxico/pharmacokinetics. As a tutorial, we first simplify a 2-compartment pharmacokinetic model by symbolic lumping. We then explore the reduction of a 6-compartment physiologically based pharmacokinetic model for 1,3-butadiene with numerical constrained lumping. The lumping methods presented here can be easily automated, and are applicable to first-order ordinary differential equation systems.
Kubesa, Petr; Horák, Jiří; Branc, Michal; Krpec, Kamil; Hopan, František; Koloničný, Jan; Ochodek, Tadeáš; Drastichová, Vendula; Martiník, Lubomír; Malcho, Milan
2014-08-01
The article deals with the combustion process for lump wood in low-power fireplaces (units to dozens of kW). Such a combustion process is cyclical in its nature, and what combustion facility users are most interested in is the frequency, at which fuel needs to be stoked to the fireplace. The paper defines the basic terms such as burnout curve and burning rate curve, which are closely related to the stocking frequency. The fuel burning rate is directly dependent on the immediate thermal power of the fireplace. This is also related to the temperature achieved in the fireplace, magnitude of flue gas losses and the ability to generate conditions favouring the full burnout of the fuel's combustible component, which, at once ensures the minimum production of combustible pollutants. Another part of the paper describes experiments conducted in traditional fireplaces with a grate, at which well-dried lump wood was combusted.
Do Lumped-Parameter Models Provide the Correct Geometrical Damping?
DEFF Research Database (Denmark)
Andersen, Lars
This paper concerns the formulation of lumped-parameter models for rigid footings on homogenous or stratified soil. Such models only contain a few degrees of freedom, which makes them ideal for inclusion in aero-elastic codes for wind turbines and other models applied to fast evaluation of struct......This paper concerns the formulation of lumped-parameter models for rigid footings on homogenous or stratified soil. Such models only contain a few degrees of freedom, which makes them ideal for inclusion in aero-elastic codes for wind turbines and other models applied to fast evaluation...... response during excitation and the geometrical damping related to free vibrations of a hexagonal footing. The optimal order of a lumped-parameter model is determined for each degree of freedom, i.e. horizontal and vertical translation as well as torsion and rocking. In particular, the necessity of coupling...
Determination of Dimensionless Attenuation Coefficient in Shaped Resonators
Daniels, C.; Steinetz, B.; Finkbeiner, J.; Raman, G.; Li, X.
2003-01-01
The value of dimensionless attenuation coefficient is an important factor when numerically predicting high-amplitude acoustic waves in shaped resonators. Both the magnitude of the pressure waveform and the quality factor rely heavily on this dimensionless parameter. Previous authors have stated the values used, but have not completely explained their methods. This work fully describes the methodology used to determine this important parameter. Over a range of frequencies encompassing the fundamental resonance, the pressure waves were experimentally measured at each end of the shaped resonators. At the corresponding dimensionless acceleration, the numerical code modeled the acoustic waveforms generated in the resonator using various dimensionless attenuation coefficients. The dimensionless attenuation coefficient that most closely matched the pressure amplitudes and quality factors of the experimental and numerical results was determined to be the value to be used in subsequent studies.
Lumped-Parameter Models for Windturbine Footings on Layered Ground
DEFF Research Database (Denmark)
Andersen, Lars
The design of modern wind turbines is typically based on lifetime analyses using aeroelastic codes. In this regard, the impedance of the foundations must be described accurately without increasing the overall size of the computationalmodel significantly. This may be obtained by the fitting...... of a lumped-parameter model to the results of a rigorous model or experimental results. In this paper, guidelines are given for the formulation of such lumped-parameter models and examples are given in which the models are utilised for the analysis of a wind turbine supported by a surface footing on a layered...
Gómez, S.S.; Pruiksma, J.
2017-01-01
In this paper simplified expressions for assessing fundamental frequency and modal damping of high-rise buildings taking into account the soil-structure interaction (SSI) are proposed. To this end, several steps have been followed. First, a 3DoF model is formulated making use of dimensionless
Dimensionless thermodynamics: a new paradigm for liquid state properties.
Sanchez, Isaac C
2014-08-07
Equations of state in the van der Waals genre suggest that saturated liquids should adhere to the following corresponding states principle (CSP): saturated liquids at the same reduced density (ρR = ρ/ρc) have comparable dimensionless thermodynamic properties. This CSP is shown to be applicable to a variety of thermodynamic properties that include entropy of vaporization, cohesive energy density, thermal expansion coefficient, isothermal compressibility, thermal pressure coefficient, compressibility factor, temperature coefficient of the vapor pressure, heat capacity difference, and surface tension. For two classes of liquids, all properties rendered dimensionless by the proper choice of scaling variables superpose to form "master curves" that illustrate the CSP. Using scaled particle theory, an improved van der Waals model is developed whose results are compared with existing experimental thermodynamic data in dimensionless form. Properly expressing thermodynamic properties in dimensionless form acts to consolidate and harmonize liquid state properties.
Dimensionless study on dynamics of pressure controlled mechanical ventilation system
International Nuclear Information System (INIS)
Shi, Yan; Niu, Jinglong; Cai, Maolin; Xu, Weiqing
2015-01-01
Dynamics of mechanical ventilation system can be referred in pulmonary diagnostics and treatments. In this paper, to conveniently grasp the essential characteristics of mechanical ventilation system, a dimensionless model of mechanical ventilation system is presented. For the validation of the mathematical model, a prototype mechanical ventilation system of a lung simulator is proposed. Through the simulation and experimental studies on the dimensionless dynamics of the mechanical ventilation system, firstly, the mathematical model is proved to be authentic and reliable. Secondly, the dimensionless dynamics of the mechanical ventilation system are obtained. Last, the influences of key parameters on the dimensionless dynamics of the mechanical ventilation system are illustrated. The study provides a novel method to study the dynamic of mechanical ventilation system, which can be referred in the respiratory diagnostics and treatment.
Classification of whole wheat flour using a dimensionless number.
Sehn, Georgia Ane Raquel; Steel, Caroline Joy
2017-11-01
The rheological standards currently used for classifying refined wheat flour for technological quality of bread are also used for whole wheat flours. The aim of this study was to evaluate the rheological and technological behavior of different whole wheat flours, as well as pre-mixes of refined wheat flour with different replacement levels of wheat bran, to develop a dimensionless number that assigns a numerical scale using results of rheological parameters to solve this problem. Through farinograph and extensograph results, most whole wheat flours evaluated presented parameters recommended for bread making, according to the current classification. However, the specific volume of breads elaborated with these flours was not suitable, that is, the rheological analyses were not able to predict the specific volume of pan bread. The development of the Sehn-Steel dimensionless number allowed establishing a classification of whole wheat flours as "suitable" (Sehn-Steel dimensionless number between 62 and 200) or "unsuitable" for the production of pan bread (Sehn-Steel dimensionless number lower than 62). Moreover, an equation that can predict the specific volume of whole pan bread through this dimensionless number was developed.
Lump solutions in SFT. Complements
Bonora, L.; Giaccari, S.; Tolla, D. D.
2011-01-01
Recently a possible violation of the equation of motion for the recently proposed lump solutions in open SFT has been pointed out in the literature. In this paper we argue that, when the issue is considered in the appropriate mathematical setting of distribution theory, no violations to the equation of motion occur.
Lumped transmission line avalanche pulser
Booth, Rex
1995-01-01
A lumped linear avalanche transistor pulse generator utilizes stacked transistors in parallel within a stage and couples a plurality of said stages, in series with increasing zener diode limited voltages per stage and decreasing balanced capacitance load per stage to yield a high voltage, high and constant current, very short pulse.
Lumped Mass Modeling for Local-Mode-Suppressed Element Connectivity
DEFF Research Database (Denmark)
Joung, Young Soo; Yoon, Gil Ho; Kim, Yoon Young
2005-01-01
connectivity parameterization (ECP) is employed. On the way to the ultimate crashworthy structure optimization, we are now developing a local mode-free topology optimization formulation that can be implemented in the ECP method. In fact, the local mode-freeing strategy developed here can be also used directly...... experiencing large structural changes, appears to be still poor. In ECP, the nodes of the domain-discretizing elements are connected by zero-length one-dimensional elastic links having varying stiffness. For computational efficiency, every elastic link is now assumed to have two lumped masses at its ends....... Choosing appropriate penalization functions for lumped mass and link stiffness is important for local mode-free results. However, unless the objective and constraint functions are carefully selected, it is difficult to obtain clear black-and-white results. It is shown that the present formulation is also...
Do Lumped-Parameter Models Provide the Correct Geometrical Damping?
DEFF Research Database (Denmark)
Andersen, Lars
2007-01-01
This paper concerns the formulation of lumped-parameter models for rigid footings on homogenous or stratified soil with focus on the horizontal sliding and rocking. Such models only contain a few degrees of freedom, which makes them ideal for inclusion in aero-elastic codes for wind turbines......-parameter models with respect to the prediction of the maximum response during excitation and the geometrical damping related to free vibrations of a footing....
Lumped-parameter Model of a Bucket Foundation
DEFF Research Database (Denmark)
Andersen, Lars; Ibsen, Lars Bo; Liingaard, Morten
2009-01-01
As an alternative to gravity footings or pile foundations, offshore wind turbines at shallow water can be placed on a bucket foundation. The present analysis concerns the development of consistent lumped-parameter models for this type of foundation. The aim is to formulate a computationally effic...... be disregarded without significant loss of accuracy. Finally, special attention is drawn to the influence of the skirt stiffness, i.e. whether the embedded part of the caisson is rigid or flexible....
Comments Simplification of thermodynamic calculations through dimensionless entropies
International Nuclear Information System (INIS)
Pitzer, K.S.; Brewer, L.
1979-01-01
The advantages of using thermodynamic quantities divided by the gas constant (H/R, G/R, etc,) in calculations are described. It is recommended that thermodynamic tables be presented in this form, so that the entries are either dimensionless or in units of kelvins
An equation for the dimensionless friction factor of consolidated ...
African Journals Online (AJOL)
An equation that relates the dimensionless friction factor of a porous medium its Reynolds number, during incompressible and compressible fluid flow through the medium is proposed. The equation is a curve fit of a graph drawn from the results of Ohirhian for water (liquid) and that of Akpokene for Nitrogen (gas) flow ...
Directory of Open Access Journals (Sweden)
Wen-Fu Zhang
2017-01-01
Full Text Available Even for the doubly symmetric I-beams under linear distributed moment, the design formulas given by codes of different countries are quite different. This paper will derive a dimensionless analytical solution via linear stability theory and propose a new design formula of the critical moment of the lateral-torsional buckling (LTB of the simply supported I-beams under linear distributed moment. Firstly, the assumptions of linear stability theory are reviewed, the dispute concerning the LTB energy equation is introduced, and then the thinking of Plate-Beam Theory, which can be used to fully resolve the challenge presented by Ojalvo, is presented briefly; secondly, by introducing the new dimensionless coefficient of lateral deflection, the new dimensionless critical moment and Wagner’s coefficient are derived naturally from the total potential energy. With these independent parameters, the new dimensionless analytical buckling equation is obtained; thirdly, the convergence performance of the dimensionless analytical solution is discussed by numerical solutions and its correctness is verified by the numerical results given by ANSYS; finally, a new trilinear mathematical model is proposed as the benchmark of formulating the design formula and, with the help of 1stOpt software, the four coefficients used in the proposed dimensionless design formula are determined.
Estimating Mass of Inflatable Aerodynamic Decelerators Using Dimensionless Parameters
Samareh, Jamshid A.
2011-01-01
This paper describes a technique for estimating mass for inflatable aerodynamic decelerators. The technique uses dimensional analysis to identify a set of dimensionless parameters for inflation pressure, mass of inflation gas, and mass of flexible material. The dimensionless parameters enable scaling of an inflatable concept with geometry parameters (e.g., diameter), environmental conditions (e.g., dynamic pressure), inflation gas properties (e.g., molecular mass), and mass growth allowance. This technique is applicable for attached (e.g., tension cone, hypercone, and stacked toroid) and trailing inflatable aerodynamic decelerators. The technique uses simple engineering approximations that were developed by NASA in the 1960s and 1970s, as well as some recent important developments. The NASA Mars Entry and Descent Landing System Analysis (EDL-SA) project used this technique to estimate the masses of the inflatable concepts that were used in the analysis. The EDL-SA results compared well with two independent sets of high-fidelity finite element analyses.
On dimensionless loading parameters for close-in blasts
Directory of Open Access Journals (Sweden)
K Micallef
2016-10-01
Full Text Available Close-range blasts pose a threat through severe damage to structures and injury or death. In this work, the spatial and temporal descriptions of a localised blast load are presented using 6 non-dimensional parameters. These are found to be solely functions of the charge stand-off distance to diameter ratio for a cylindrically-shaped charge. Numerical simulations of a localised blast are performed using AUTODYN, where the pressure variation on a rigid barrier for various charge stand-off/diameter combinations is obtained. The least-square regression is then utilised to obtain the relationship between stand-off/diameter ratio and dimensionless loading parameters. The relevant expressions and dimensionless charts are presented. The proposed equations are verified by comparing experimental data with numerical results obtained by finite element analysis (FEA of blast loaded steel plates (using the user-defined subroutine VDLOAD implemented in the FEA package ABAQUS/Explicit. Excellent correlation of the measured permanent displacement with numerically predicted results is obtained.
Transport phenomena and dimensionless numbers: towards a new methodological approach
Bezuglyi, B. A.; Ivanova, N. A.; Sizova, L. V.
2017-05-01
This review presents a new methodical approach to the classification of dimensionless numbers as pair relationships of the main forces controlling transport phenomena in fluids at the macroscopic level by using a tabulated form. To memorize the transfer numbers at the molecular level a rule in the form of a mnemonic triangle is suggested. The structure of some traditional dimensional numbers presented as the ratio of more than two forces, or the ratio of a force to a geometric mean of two other ones, is also discussed. A classification of natural convection as the interaction of body forces and surface forces, taking into account that sensitive to the force field the fluid density and the surface tension depends on temperature or composition, is presented.
Dimensionless Numbers Expressed in Terms of Common CVD Process Parameters
Kuczmarski, Maria A.
1999-01-01
A variety of dimensionless numbers related to momentum and heat transfer are useful in Chemical Vapor Deposition (CVD) analysis. These numbers are not traditionally calculated by directly using reactor operating parameters, such as temperature and pressure. In this paper, these numbers have been expressed in a form that explicitly shows their dependence upon the carrier gas, reactor geometry, and reactor operation conditions. These expressions were derived for both monatomic and diatomic gases using estimation techniques for viscosity, thermal conductivity, and heat capacity. Values calculated from these expressions compared well to previously published values. These expressions provide a relatively quick method for predicting changes in the flow patterns resulting from changes in the reactor operating conditions.
Application of lumped-parameter models
Energy Technology Data Exchange (ETDEWEB)
Ibsen, Lars Bo; Liingaard, M.
2006-12-15
This technical report concerns the lumped-parameter models for a suction caisson with a ratio between skirt length and foundation diameter equal to 1/2, embedded into an viscoelastic soil. The models are presented for three different values of the shear modulus of the subsoil. Subsequently, the assembly of the dynamic stiffness matrix for the foundation is considered, and the solution for obtaining the steady state response, when using lumped-parameter models is given. (au)
Murari, A.; Peluso, E.; Lungaroni, M.; Gelfusa, M.; Gaudio, P.
2016-02-01
In many scientific applications, it is important to investigate how certain properties scale with the parameters of the systems. The experimental studies of scalings have traditionally been addressed with log regression, which limits the results to power laws and to theoretical and not data-driven dimensionless quantities. This has also been the case in nuclear fusion, in which the scaling of the energy confinement time is a crucial aspect in understanding the physics of transport and in the design of future devices. Traditionally two main assumptions are at the basis of the most widely accepted empirical scaling laws for the confinement time: (a) the dimensionless variables used are the ones derived from the symmetries of the Vlasov equation; (b) the final scalings have the mathematical form of power laws. In this paper, it is shown how symbolic regression (SR), implemented with genetic programming (GP) techniques, can be used to test these hypotheses. Neither assumption is confirmed by the available data of the multi-machine International Tokamak Physics Activity (ITPA) of validated tokamak discharges. The statistically soundest expressions are not power laws and cannot be formulated in terms of the traditional dimensionless quantities. The consequences of the data-driven scaling laws obtained are both practical and theoretical: the confinement time for the ITER can be significantly shorter than foreseen by power laws and different dimensionless variables should be considered for theoretical investigations. On the other hand, higher quality databases should be built to reduce the uncertainties in the extrapolations. It is also worth emphasising that the proposed methodology is fully general and therefore can be applied to any field of science.
Triple assessment of breast lump
International Nuclear Information System (INIS)
Ahmed, I.; Nazir, R.; Chaudhary, M.Y.
2007-01-01
To determine the sensitivity, specificity, positive and negative predictive values of triple test (T T) consisting of physical examination (PE), mammography, fine needle aspiration cytology (FNAC) in the evaluation and characterization of palpable breast lump. Secondly, whether this can be employed as an alternative for tru cut/ excisional biopsy. It comprised of 35 consecutive females presenting in the breast clinic with palpable lump. Females below 35 years of age were excluded due to low sensitivity of the mammography in depiction of focal breast lesions resulting from glandular parenchyma. Patients with acute inflammatory signs, fungating masses, pregnant ladies as well as those with cystic lesions, as confirmed by ultrasound, were also excluded from the study. Number, size and recurrent masses did not influence the inclusion criterion. Detailed history and physical examination was carried out as per established protocol. It was followed by mammography and FNAC. All cases underwent excisional biopsy irrespective of the results of the triple test. The patients age ranged from 35 to 75 years with mean age of 45.97. Amongst these, 19 cases were benign (54.28 %) and 16 cases (45.71 %) were malignant. The triple test (T T) was scored as concordant if the elements had either all malignant or all benign results. The triple test was non-concordant if the elements had neither all malignant nor all benign results. The T T was concordant in 19 cases (54.28 %) i.e all the benign cases detected by the triple test were benign on final biopsy (100 % specificity and NPV), all the malignant lesions detected by T T turned out to be malignant on final biopsy (100 % sensitivity and PPV). Triple test was nonconcordant in 16 cases (45.71 %). Triple Test was scored as benign or malignant based upon the combined results of two elements amongst three components. Out of these, 11 cases were malignant and 5 were benign. In 4 cases, the components of the triple test were suspicious i
Analysis of transient heat conduction in a PWR fuel rod by an improved lumped parameter approach
Energy Technology Data Exchange (ETDEWEB)
Dourado, Eneida Regina G. [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil); Cotta, Renato M. [Coordenacao de Pos-Graduacao e Pesquisa de Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Mecanica; Jian, Su, E-mail: eneidadourado@gmail.com, E-mail: sujian@nuclear.ufrj.br, E-mail: cotta@mecanica.ufrj.br [Coordenacao de Pos-Graduacao e Pesquisa de Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear
2017-07-01
This paper aims to analyze transient heat conduction in a nuclear fuel rod by an improved lumped parameter approach. One-dimensional transient heat conduction is considered, with the circumferential symmetry assumed and the axial conduction neglected. The thermal conductivity and specific heat in the fuel pellet are considered temperature dependent, while the thermophysical properties of the cladding are considered constant. Hermite approximation for integration is used to obtain the average temperature and heat flux in the radial direction. Significant improvement over the classical lumped parameter formulation has been achieved. The proposed model can be also used in dynamic analysis of PWR and nuclear power plant simulators. (author)
Lumped-Parameter Models for Wind-Turbine Footings on Layered Ground
DEFF Research Database (Denmark)
Andersen, Lars; Liingaard, Morten
2007-01-01
The design of modern wind turbines is typically based on lifetime analyses using aeroelastic codes. In this regard, the impedance of the foundations must be described accurately without increasing the overall size of the computational model significantly. This may be obtained by the fitting...... of a lumped-parameter model to the results of a rigorous model or experimental results. In this paper, guidelines are given for the formulation of such lumped-parameter models and examples are given in which the models are utilised for the analysis of a wind turbine supported by a surface footing on a layered...
A dimensionless parameter for classifying hemodynamics in intracranial
Asgharzadeh, Hafez; Borazjani, Iman
2015-11-01
Rupture of an intracranial aneurysm (IA) is a disease with high rates of mortality. Given the risk associated with the aneurysm surgery, quantifying the likelihood of aneurysm rupture is essential. There are many risk factors that could be implicated in the rupture of an aneurysm. However, the most important factors correlated to the IA rupture are hemodynamic factors such as wall shear stress (WSS) and oscillatory shear index (OSI) which are affected by the IA flows. Here, we carry out three-dimensional high resolution simulations on representative IA models with simple geometries to test a dimensionless number (first proposed by Le et al., ASME J Biomech Eng, 2010), denoted as An number, to classify the flow mode. An number is defined as the ratio of the time takes the parent artery flow transports across the IA neck to the time required for vortex ring formation. Based on the definition, the flow mode is vortex if An>1 and it is cavity if AnOSI on the human subject IA. This work was supported partly by the NIH grant R03EB014860, and the computational resources were partly provided by CCR at UB. We thank Prof. Hui Meng and Dr. Jianping Xiang for providing us the database of aneurysms and helpful discussions.
Lump solutions to nonlinear partial differential equations via Hirota bilinear forms
Ma, Wen-Xiu; Zhou, Yuan
2018-02-01
Lump solutions are analytical rational function solutions localized in all directions in space. We analyze a class of lump solutions, generated from quadratic functions, to nonlinear partial differential equations. The basis of success is the Hirota bilinear formulation and the primary object is the class of positive multivariate quadratic functions. A complete determination of quadratic functions positive in space and time is given, and positive quadratic functions are characterized as sums of squares of linear functions. Necessary and sufficient conditions for positive quadratic functions to solve Hirota bilinear equations are presented, and such polynomial solutions yield lump solutions to nonlinear partial differential equations under the dependent variable transformations u = 2(ln f) x and u = 2(ln f) xx, where x is one spatial variable. Applications are made for a few generalized KP and BKP equations.
Hyperelastic modelling and parametric study of soft tissue embedded lump for MIS applications.
Sokhanvar, S; Dargahi, J; Packirisamy, M
2008-09-01
The existing MIS (minimally invasive surgery) instruments have caused severe restrictions to surgeons' tactile perception. In particular, palpation, which is an important technique in open surgery to assess the softness of the tissue and to detect any hidden lumps, is entirely absent in MIS procedures. Many researchers have developed smart endoscopic graspers to rectify different aspects of this problem. However, the effect of an anatomical feature in general and a lump in particular on the stress distribution on the sensitive surfaces of the smart MIS graspers still needs a lot of attention. This paper investigates the effect of the important parameters of a lump on the stress distribution at the contact surface and subsequently the output of smart endoscopic graspers. Using experimental stress-strain compression test data, the material parameters required for the Mooney-Rivlin model were obtained and used in hyperelastic finite element analysis. The influence of size, depth and stiffness of the lump on the stress distribution at the contact surface are shown and discussed. The results of the non-linear finite element analysis were validated against experiments conducted on elastomeric material replicating soft tissue. The consistency between finite element analysis results and experimental work validates the developed model, which is based on the hyperelastic formulation. The finite element analysis results obtained in this study are particularly useful for the development of an inverse model. The inverse model would extract fundamental information, such as size, depth and stiffness, of any hidden lump, using the outputs of the sensors.
Wang, Yun; Chen, Ken S.
2016-05-01
In the present work, a three-dimension (3-D) model of polymer electrolyte fuel cells (PEFCs) is employed to investigate the complex, non-isothermal, two-phase flow in the gas diffusion layer (GDL). Phase change in gas flow channels is explained, and a simplified approach accounting for phase change is incorporated into the fuel cell model. It is found that the liquid water contours in the GDL are similar along flow channels when the channels are subject to two-phase flow. Analysis is performed on a dimensionless parameter Da0 introduced in our previous paper [Y. Wang and K. S. Chen, Chemical Engineering Science 66 (2011) 3557-3567] and the parameter is further evaluated in a realistic fuel cell. We found that the GDL's liquid water (or liquid-free) region is determined by the Da0 number which lumps several parameters, including the thermal conductivity and operating temperature. By adjusting these factors, a liquid-free GDL zone can be created even though the channel stream is two-phase flow. Such a liquid-free zone is adjacent to the two-phase region, benefiting local water management, namely avoiding both severe flooding and dryness.
Application of lumped-parameter models
DEFF Research Database (Denmark)
Ibsen, Lars Bo; Liingaard, Morten
This technical report concerns the lumped-parameter models for a suction caisson with a ratio between skirt length and foundation diameter equal to 1/2, embedded into an viscoelastic soil. The models are presented for three different values of the shear modulus of the subsoil (section 1.1). Subse......This technical report concerns the lumped-parameter models for a suction caisson with a ratio between skirt length and foundation diameter equal to 1/2, embedded into an viscoelastic soil. The models are presented for three different values of the shear modulus of the subsoil (section 1...
Directory of Open Access Journals (Sweden)
U. WALZER
1980-06-01
Full Text Available The relationships existing between melting temperature and other
macroscopic physical quantities are investigated. A new dimensionless
quantity Q(1 not containing the Grtineisen parameter proves to be suited for serving in future studies as a tool for the determination of the melting temperature in the outer core of the Earth. The pressure dependence of more general dimensionless quantities Q„ is determined analytically and, for the chemical elements, numerically, too. The patterns of various interesting dimensionless quantities are shown in the Periodic Table and compared.
Caliper measurement to improve clinical assessment of palpable neck lumps.
Wasson, J; Amonoo-Kuofi, K; Scrivens, J; Pfleiderer, A
2012-05-01
One-stop neck lump clinics with ultrasonography and cytopathology support are an expensive and finite resource. Consequently, many neck lump patients are assessed in general ear, nose and throat or head and neck clinics. Optimal clinical assessment of neck lump size is important to guide investigation, monitor change and provisionally stage nodal disease. The aims of this study were to investigate whether caliper measurement is more accurate than clinical palpation in assessing neck lump size and whether caliper measurement of neck lump size correlates closely with accurate ultrasonography measurement. A prospective study was carried out involving 50 patients with clinically palpable neck lumps presenting to the one-stop neck lump clinic. Long and short axis neck lump dimensions were estimated first by clinical palpation and second by caliper measurement. Estimations were compared with accurate ultrasonography measurement. The mean combined long and short axis measurement deviation from accurate ultrasonography measurement was smaller for caliper measurement (7.80 mm) than for clinical palpation (12.38 mm) (p caliper measurement of neck lumps (p = 0.462). Caliper measurement is more accurate than clinical palpation in estimating the size of clinically palpable neck lumps. The use of calipers to measure the skin surface dimensions of palpable neck lumps is statistically comparable to accurate ultrasonography measurement.
A lumped parameter model of plasma focus
International Nuclear Information System (INIS)
Gonzalez, Jose H.; Florido, Pablo C.; Bruzzone, H.; Clausse, Alejandro
1999-01-01
A lumped parameter model to estimate neutron emission of a plasma focus (PF) device is developed. The dynamic of the current sheet is calculated using a snowplow model, and the neutron production with the thermal fusion cross section for a deuterium filling gas. The results were contrasted as a function of the filling pressure with experimental measurements of a 3.68 KJ Mather-type PF. (author)
Study of dimensionless quantities to analyse front and rear wall of ...
Indian Academy of Sciences (India)
LBW) process inﬂuence the associated heat and mass transfer. In an attempt to describe these complexities for eventual optimization of LBW parameters, a dimensionless analysis using Mach (Ma), Raleigh (Ra), Reynolds (Re) and Marangoni ...
Lumped elements for RF and microwave circuits
Bahl, Inder
2003-01-01
Due to the unprecedented growth in wireless applications over the past decade, development of low-cost solutions for RF and microwave communication systems has become of great importance. This practical new book is the first comprehensive treatment of lumped elements, which are playing a critical role in the development of the circuits that make these cost-effective systems possible. The books offers you an in-depth understanding of the different types of RF and microwave circuit elements, including inductors, capacitors, resistors, transformers, via holes, airbridges, and crossovers. Support
Importance theory for lumped-parameter systems
International Nuclear Information System (INIS)
Cady, K.B.; Kenton, M.A.; Ward, J.C.; Piepho, M.G.
1981-01-01
A general sensitivity theory has been developed for nonlinear lumped parameter system simulations. The point of departure is general perturbation theory for nonlinear systems. Importance theory as developed here allows the calculation of the sensitivity of a response function to any physical or design parameter; importance of any equation or term or physical effect in the system model on the response function; variance of the response function caused by the variances and covariances of all physical parameters; and approximate effect on the response function of missing physical phenomena or incorrect parameters
The role of men in early detection of their spouses' breast lump(s ...
African Journals Online (AJOL)
We aim to determine whether men can be of help in the early detection of lumps in their spouses' breast. 230 questionnaires were administered to married men. The responses were accepted as “yes” or “no. 217 men (94.35%) responded. 195 (89.86%) were aware of breast cancer. 212 ( 97.7%) were either Christians or ...
Directory of Open Access Journals (Sweden)
Chao-Hsien Liaw
2014-12-01
Full Text Available A regional-level and dimensionless analysis for designing a domestic rainwater harvesting system (DRWHS was developed. To consider various combinations of water demand, storage capacity, effective roof area, and rainfall in DRWHS design, two dimensionless ratios were used, namely, demand fraction and storage fraction, along with a relationship between the two ratios. Firstly, Northern Taiwan was divided into four sub-regions through cluster analysis based on the average annual 10-day rainfall distribution at rainfall stations and administrative districts. Easy-to-use dimensionless curves between demand fraction and storage fraction were obtained for five rainwater supply reliabilities of the DRWHS for the four sub-regions. Based on the dimensionless curves, a nomogram was constructed for designing DRWHSs at a rainwater supply reliability of 95% in the sub-region I. Storage capacities determined from the dimensionless curves showed a close fit with those determined from simulated values, but were larger than the values estimated from the method presented in the Green Building Evaluation Manual in most situations. The methodology developed herein can be used effectively for the preliminary design of a DRWHS and for overcoming the difficulties faced in designing a DRWHS without rainfall data and with incomplete rainfall data.
A nonlinear lumped model for ultrasound systems using CMUT arrays.
Satir, Sarp; Degertekin, F Levent
2015-10-01
We present a nonlinear lumped model that predicts the electrical input-output behavior of an ultrasonic system using CMUTs with arbitrary array/membrane/electrode geometry in different transmit-receive configurations and drive signals. The receive-only operation, where the electrical output signal of the CMUT array in response to incident pressure field is calculated, is included by modifying the boundary elementbased vibroacoustic formulation for a CMUT array in rigid baffle. Along with the accurate large signal transmit model, this formulation covers pitch-catch and pulse-echo operation when transmit and receive signals can be separated in time. In cases when this separation is not valid, such as CMUTs used in continuous wave transmit-receive mode, pulse-echo mode with a nearby hard or soft wall or in a bounded space such as in a microfluidic channel, an efficient formulation based on the method of images is used. Some of these particular applications and the overall modeling approach have been validated through comparison with finite element analysis on specific examples including CMUTs with multiple electrodes. To further demonstrate the capability of the model for imaging applications, the two-way response of a partial dual-ring intravascular ultrasound array is simulated using a parallel computing cluster, where the output currents of individual array elements are calculated for given input pulse and compared with experimental results. With its versatility, the presented model can be a useful tool for rapid iterative CMUT-based system design and simulation for a broad range of ultrasonic applications.
Lumped Parameters Model of a Crescent Pump
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Massimo Rundo
2016-10-01
Full Text Available This paper presents the lumped parameters model of an internal gear crescent pump with relief valve, able to estimate the steady-state flow-pressure characteristic and the pressure ripple. The approach is based on the identification of three variable control volumes regardless of the number of gear teeth. The model has been implemented in the commercial environment LMS Amesim with the development of customized components. Specific attention has been paid to the leakage passageways, some of them affected by the deformation of the cover plate under the action of the delivery pressure. The paper reports the finite element method analysis of the cover for the evaluation of the deflection and the validation through a contactless displacement transducer. Another aspect described in this study is represented by the computational fluid dynamics analysis of the relief valve, whose results have been used for tuning the lumped parameters model. Finally, the validation of the entire model of the pump is presented in terms of steady-state flow rate and of pressure oscillations.
The liquid lift: Looking natural without lumps
Directory of Open Access Journals (Sweden)
Iñigo de Felipe
2015-01-01
Full Text Available Context: Hyaluronic acid (HA is the most common filler used to rejuvenate. Today, a three-dimensional approach prevails over previous techniques in which this material was used in specific areas of the face such as the nasolabial fold, the marionette line, and the eye trough giving a strange appearance that does not look natural. Even with a volumizing purpose, the injection of HA can sometimes produce clinically detectable nodules or lumps where the filler is deposited. Aims: To develop a new technique of injecting HA that can provide more natural results and avoid the lumpiness and nodular appearance that sometimes occurs with the injection of HA. To detect whether mixing HA with diluted anesthetic agent modifies its behavior. Settings and Design: Prospective, case control, single-center study on a private clinic setting. Materials and Methods: Eighty six patients were enrolled in this study. All of them had a previous treatment with nondiluted HA using a needle at least a year before. Patients were injected with 8 mL of reticulated HA (RHA mixed with 6 mL of saline and 2 mL of anesthetic agent. The mixture was administered through a cannula inserted in the face, one at mid-cheek and another at frontal-temporal point of entry. Owing to the lifting effect of this mixture we called this procedure liquid lift (LL. Patients were evaluated 1 month, 6 months, and a year later and asked to compare the LL with previous experiences in terms of natural look, pain, and appearance of nodules. Statistical Analysis Used: Student′s t-test. Results: One month after the treatment, 83 out of 86 patients (96.5% thought LL produced a more natural look than the previous treatment with the needle. Sixty two (72% considered LL less painful than the previous treatment and only eight (9.3% could detect lumps or nodules 1 month after LL was performed compared with 46 (53.5% that described this problem with previous needle injections. The incidence of bruising was
28 CFR 523.16 - Lump sum awards.
2010-07-01
... Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INMATE ADMISSION, CLASSIFICATION, AND TRANSFER COMPUTATION OF SENTENCE Extra Good Time § 523.16 Lump sum awards. Any staff member may recommend to the Warden the approval of an inmate for a lump sum award of extra good time. Such recommendations...
Directory of Open Access Journals (Sweden)
Masaaki Shida, MD, PhD
2017-12-01
Conclusions:. The appropriate treatment for breast lumps after breast augmentation with autologous fat grafting must be selected according to the nature of the lumps. Ultrasound is essential for diagnosing the breast lump type and determining the best treatment.
where σ is a dimensionless number in ppm, B is the field ...
African Journals Online (AJOL)
a
As computational chemists tend to think of shieldings as absolute rather than relative to a reference molecule so it is worth repeating here the language and equations used in different contexts. The absolute shielding σ is defined as: (1) where σ is a dimensionless number in ppm, B is the field experienced by the nucleus ...
Energy Technology Data Exchange (ETDEWEB)
Mian, Muhammad Umer, E-mail: umermian@gmail.com; Khir, M. H. Md.; Tang, T. B. [Department of Electrical and Electronic Engineering, Universiti Teknologi PETRONAS, Tronoh, Perak (Malaysia); Dennis, John Ojur [Department of Fundamental & Applied Sciences, Universiti Teknologi PETRONAS, Tronoh, Perak (Malaysia); Riaz, Kashif; Iqbal, Abid [Faculty of Electronics Engineering, GIK Institute of Engineering Sciences and Technology, Topi, Khyber Pakhtunkhaw (Pakistan); Bazaz, Shafaat A. [Department of Computer Science, Center for Advance Studies in Engineering, Islamabad (Pakistan)
2015-07-22
Pre-fabrication, behavioural and performance analysis with computer aided design (CAD) tools is a common and fabrication cost effective practice. In light of this we present a simulation methodology for a dual-mass oscillator based 3 Degree of Freedom (3-DoF) MEMS gyroscope. 3-DoF Gyroscope is modeled through lumped parameter models using equivalent circuit elements. These equivalent circuits consist of elementary components which are counterpart of their respective mechanical components, used to design and fabricate 3-DoF MEMS gyroscope. Complete designing of equivalent circuit model, mathematical modeling and simulation are being presented in this paper. Behaviors of the equivalent lumped models derived for the proposed device design are simulated in MEMSPRO T-SPICE software. Simulations are carried out with the design specifications following design rules of the MetalMUMPS fabrication process. Drive mass resonant frequencies simulated by this technique are 1.59 kHz and 2.05 kHz respectively, which are close to the resonant frequencies found by the analytical formulation of the gyroscope. The lumped equivalent circuit modeling technique proved to be a time efficient modeling technique for the analysis of complex MEMS devices like 3-DoF gyroscopes. The technique proves to be an alternative approach to the complex and time consuming couple field analysis Finite Element Analysis (FEA) previously used.
Mian, Muhammad Umer; Dennis, John Ojur; Khir, M. H. Md.; Riaz, Kashif; Iqbal, Abid; Bazaz, Shafaat A.; Tang, T. B.
2015-07-01
Pre-fabrication, behavioural and performance analysis with computer aided design (CAD) tools is a common and fabrication cost effective practice. In light of this we present a simulation methodology for a dual-mass oscillator based 3 Degree of Freedom (3-DoF) MEMS gyroscope. 3-DoF Gyroscope is modeled through lumped parameter models using equivalent circuit elements. These equivalent circuits consist of elementary components which are counterpart of their respective mechanical components, used to design and fabricate 3-DoF MEMS gyroscope. Complete designing of equivalent circuit model, mathematical modeling and simulation are being presented in this paper. Behaviors of the equivalent lumped models derived for the proposed device design are simulated in MEMSPRO T-SPICE software. Simulations are carried out with the design specifications following design rules of the MetalMUMPS fabrication process. Drive mass resonant frequencies simulated by this technique are 1.59 kHz and 2.05 kHz respectively, which are close to the resonant frequencies found by the analytical formulation of the gyroscope. The lumped equivalent circuit modeling technique proved to be a time efficient modeling technique for the analysis of complex MEMS devices like 3-DoF gyroscopes. The technique proves to be an alternative approach to the complex and time consuming couple field analysis Finite Element Analysis (FEA) previously used.
Wang, Dong; Tsui, Kwok-Leung
2018-01-01
Bearing-supported shafts are widely used in various machines. Due to harsh working environments, bearing performance degrades over time. To prevent unexpected bearing failures and accidents, bearing performance degradation assessment becomes an emerging topic in recent years. Bearing performance degradation assessment aims to evaluate the current health condition of a bearing through a bearing health indicator. In the past years, many signal processing and data mining based methods were proposed to construct bearing health indicators. However, the upper and lower bounds of these bearing health indicators were not theoretically calculated and they strongly depended on historical bearing data including normal and failure data. Besides, most health indicators are dimensional, which connotes that these health indicators are prone to be affected by varying operating conditions, such as varying speeds and loads. In this paper, based on the principle of squared envelope analysis, we focus on theoretical investigation of bearing performance degradation assessment in the case of additive Gaussian noises, including distribution establishment of squared envelope, construction of a generalized dimensionless bearing health indicator, and mathematical calculation of the upper and lower bounds of the generalized dimensionless bearing health indicator. Then, analyses of simulated and real bearing run to failure data are used as two case studies to illustrate how the generalized dimensionless health indicator works and demonstrate its effectiveness in bearing performance degradation assessment. Results show that squared envelope follows a noncentral chi-square distribution and the upper and lower bounds of the generalized dimensionless health indicator can be mathematically established. Moreover, the generalized dimensionless health indicator is sensitive to an incipient bearing defect in the process of bearing performance degradation.
Decay of Kadomtsev-Petviashvili lumps in dissipative media
Clarke, S.; Gorshkov, K.; Grimshaw, R.; Stepanyants, Y.
2018-03-01
The decay of Kadomtsev-Petviashvili lumps is considered for a few typical dissipations-Rayleigh dissipation, Reynolds dissipation, Landau damping, Chezy bottom friction, viscous dissipation in the laminar boundary layer, and radiative losses caused by large-scale dispersion. It is shown that the straight-line motion of lumps is unstable under the influence of dissipation. The lump trajectories are calculated for two most typical models of dissipation-the Rayleigh and Reynolds dissipations. A comparison of analytical results obtained within the framework of asymptotic theory with the direct numerical calculations of the Kadomtsev-Petviashvili equation is presented. Good agreement between the theoretical and numerical results is obtained.
International Nuclear Information System (INIS)
Caldarelli, Marco M.; Dias, Oscar J.C.; Emparan, Roberto; Klemm, Dietmar
2009-01-01
The old suggestive observation that black holes often resemble lumps of fluid has recently been taken beyond the level of an analogy to a precise duality. We investigate aspects of this duality, and in particular clarify the relation between area minimization of the fluid vs. area maximization of the black hole horizon, and the connection between surface tension and curvature of the fluid, and surface gravity of the black hole. We also argue that the Rayleigh-Plateau instability in a fluid tube is the holographic dual of the Gregory-Laflamme instability of a black string. Associated with this fluid instability there is a rich variety of phases of fluid solutions that we study in detail, including in particular the effects of rotation. We compare them against the known results for asymptotically flat black holes finding remarkable agreement. Furthermore, we use our fluid results to discuss the unknown features of the gravitational system. Finally, we make some observations that suggest that asymptotically flat black holes may admit a fluid description in the limit of large number of dimensions.
Directory of Open Access Journals (Sweden)
Hristova Mariana
2012-01-01
Full Text Available Dimensionless experimental formulae based on a rational reciprocal function for correlation of flashpoint data of binary mixtures of two flammable components have been developed. The formulae are based on data obtained from flash-point experiments. The proposed approach requires only two coefficients, molar fraction of components and flashpoint temperatures of the pure flammable components to be known in advance. Literature data were used for formulae verification and validation obtained results indicate that accuracy is comparable and to some extent better than that of conventional flash point prediction models. Dimensional analysis and scaling of data have been performed in order to define the correct construction of the equation fitting flash-point data in dimensionless form using the independent variables suggested by Catoire. Stefan number relevant flash-point of a single compound or a blend has been defined.
Approach to a Lump in the Breast: A Regional Perspective
Directory of Open Access Journals (Sweden)
Kwok Leung Cheung
2005-01-01
Full Text Available The clinical presentation, investigation and treatment of women with breast lumps are greatly influenced by geographical factors. These impact disease patterns and their presentation (e.g. socioeconomic/educational status and cultural/religious beliefs and the availability of specialist health care personnel and facilities. The differential diagnoses of a breast lump include breast cancer, benign solid and cystic lumps and inflammatory conditions. The likelihood of a diagnosis relates more to geographical area, age, ethnic origin, family history of breast cancer, presence of high-risk pathology, endemic infection, smoking, pregnancy and lactation history, puerperal care and health education. Investigations and treatments vary more according to the availability of expertise and facilities (e.g. combined diagnostic clinic staffed by breast surgeon and radiologist; breast radiologist to carry out image-guided diagnostic and therapeutic procedures. This article discusses the clinical assessment and investigation of breast lumps and possible treatments from an Asia Pacific perspective.
A dimensionless approach for the runoff peak assessment: effects of the rainfall event structure
Gnecco, Ilaria; Palla, Anna; La Barbera, Paolo
2018-02-01
The present paper proposes a dimensionless analytical framework to investigate the impact of the rainfall event structure on the hydrograph peak. To this end a methodology to describe the rainfall event structure is proposed based on the similarity with the depth-duration-frequency (DDF) curves. The rainfall input consists of a constant hyetograph where all the possible outcomes in the sample space of the rainfall structures can be condensed. Soil abstractions are modelled using the Soil Conservation Service method and the instantaneous unit hydrograph theory is undertaken to determine the dimensionless form of the hydrograph; the two-parameter gamma distribution is selected to test the proposed methodology. The dimensionless approach is introduced in order to implement the analytical framework to any study case (i.e. natural catchment) for which the model assumptions are valid (i.e. linear causative and time-invariant system). A set of analytical expressions are derived in the case of a constant-intensity hyetograph to assess the maximum runoff peak with respect to a given rainfall event structure irrespective of the specific catchment (such as the return period associated with the reference rainfall event). Looking at the results, the curve of the maximum values of the runoff peak reveals a local minimum point corresponding to the design hyetograph derived according to the statistical DDF curve. A specific catchment application is discussed in order to point out the dimensionless procedure implications and to provide some numerical examples of the rainfall structures with respect to observed rainfall events; finally their effects on the hydrograph peak are examined.
A triangular model of dimensionless runoff producing rainfall hyetographs in Texas
Asquith, W.H.; Bumgarner, J.R.; Fahlquist, L.S.
2003-01-01
A synthetic triangular hyetograph for a large data base of Texas rainfall and runoff is needed. A hyetograph represents the temporal distribution of rainfall intensity at a point or over a watershed during a storm. Synthetic hyetographs are estimates of the expected time distribution for a design storm and principally are used in small watershed hydraulic structure design. A data base of more than 1,600 observed cumulative hyetographs that produced runoff from 91 small watersheds (generally less than about 50 km2) was used to provide statistical parameters for a simple triangular shaped hyetograph model. The model provides an estimate of the average hyetograph in dimensionless form for storm durations of 0 to 24 hours and 24 to 72 hours. As a result of this study, the authors concluded that the expected dimensionless cumulative hyetographs of 0 to 12 hour and 12 to 24 hour durations were sufficiently similar to be combined with minimal information loss. The analysis also suggests that dimensionless cumulative hyetographs are independent of the frequency level or return period of total storm depth and thus are readily used for many design applications. The two triangular hyetographs presented are intended to enhance small watershed design practice in applicable parts of Texas.
Dimensionless Analysis on the Characteristics of Pneumatic Booster Valve with Energy Recovery
Directory of Open Access Journals (Sweden)
Fan Yang
2016-01-01
Full Text Available Factories are increasingly reducing their air supply pressures in order to save energy. Hence, there is a growing demand for pneumatic booster valves to overcome the local pressure deficits in modern pneumatic systems. To further improve energy efficiency, a new type of booster valve with energy recovery (BVER is proposed. The BVER principle is presented in detail, and a dimensionless mathematical model is established based on flow rate, gas state, and energy conservation. The mathematics model was transformed into a dimensionless model by accurately selecting the reference values. Subsequently the dimensionless characteristics of BVER were found. BVER energy efficiency is calculated based on air power. The boost ratio is found to be mainly affected by the operational parameters. Among the structural ones, the recovery/boost chamber area ratio and the sonic conductance of the chambers are the most influential. The boost ratio improves by 15%–25% compared to that of a booster valve without an energy recovery chamber. The efficiency increases by 5%–10% depending on the supply pressure. A mathematical model is validated by experiment, and this research provides a reference for booster valve optimisation and energy saving.
Rutting resistance of asphalt mixture with cup lumps modified binder
Shaffie, E.; Hanif, W. M. M. Wan; Arshad, A. K.; Hashim, W.
2017-11-01
Rutting is the most common pavement distress in pavement structures which occurs mainly due to several factors such as increasing of traffic volume, climatic conditions and also due to construction design errors. This failure reduced the service life of the pavement, reduced driver safety and increase cost of maintenance. Polymer Modified Binder has been observed for a long time in improving asphalt pavement performance. Research shows that the use of polymer in bituminous mix not only improve the resistance to rutting but also increase the life span of the pavement. This research evaluates the physical properties and rutting performance of dense graded Superpave-designed HMA mix. Two different types of dense graded Superpave HMA mix were developed consists of unmodified binder mix (UMB) and cup lumps rubber (liquid form) modified binder mix (CLMB). Natural rubber polymer modified binder was prepared from addition of 8 percent of cup lumps into binder. Results showed that all the mixes passed the Superpave volumetric properties criteria which indicate that these mixtures were good with respect to durability and flexibility. Furthermore, rutting results from APA rutting test was determined to evaluate the performance of these mixtures. The rutting result of CLMB demonstrates better resistance to rutting than those prepared using UMB mix. Addition of cup lumps rubber in asphalt mixture was found to be significant, where the cup lumps rubber has certainly improves the binder properties and enhanced its rutting resistance due to greater elasticity offered by the cup lumps rubber particles. It shows that the use of cup lumps rubber can significantly reduce the rut depth of asphalt mixture by 41% compared to the minimum rut depth obtained for the UMB mix. Therefore, it can be concluded that the cup lumps rubber is suitable to be used as a modifier to modified binder in order to enhance the properties of the binder and thus improves the performance of asphalt mixes.
Error analysis of dimensionless scaling experiments with multiple points using linear regression
International Nuclear Information System (INIS)
Guercan, Oe.D.; Vermare, L.; Hennequin, P.; Bourdelle, C.
2010-01-01
A general method of error estimation in the case of multiple point dimensionless scaling experiments, using linear regression and standard error propagation, is proposed. The method reduces to the previous result of Cordey (2009 Nucl. Fusion 49 052001) in the case of a two-point scan. On the other hand, if the points follow a linear trend, it explains how the estimated error decreases as more points are added to the scan. Based on the analytical expression that is derived, it is argued that for a low number of points, adding points to the ends of the scanned range, rather than the middle, results in a smaller error estimate. (letter)
Rigorous theoretical derivation of lumped models to transmission line systems
International Nuclear Information System (INIS)
Zhao Jixiang
2012-01-01
By virtue of the negative electric parameter concept, i.e. negative lumped resistance, inductance, conductance and capacitance (N-RLGC), the lumped equivalent models of transmission line systems, including the circuit model, two-port π-network and T-network, are given. We start from the N-segment-ladder-like equivalent networks composed distributed parameters, and achieve the input impedance in the form of a continued fraction. Utilizing the continued fraction theory, the expressions of input impedance are obtained under three kinds of extreme cases, i.e. the load impedances are equal to zero, infinity and characteristic impedance, respectively. When the number of segment N is limited to infinity, they are transformed to lumped elements. Comparison between the distributed model and lumped model of transmission lines, the expression of tanh γd, which is the key term in the transmission line equations, are obtained by RLGC, furthermore, according to input admittance, admittance matrix and ABCD matrix of transmission lines, the lumped equivalent circuit models, π-networks and T-networks have been given. The models are verified in the frequency and time domain, respectively, showing that the models are accurate and efficient. (semiconductor integrated circuits)
Application of Mass Lumped Higher Order Finite Elements
International Nuclear Information System (INIS)
J. Chen, H.R. Strauss, S.C. Jardin, W. Park, L.E. Sugiyama, G. Fu, J. Breslau
2005-01-01
There are many interesting phenomena in extended-MHD such as anisotropic transport, mhd, 2-fluid effects stellarator and hot particles. Any one of them challenges numerical analysts, and researchers are seeking for higher order methods, such as higher order finite difference, higher order finite elements and hp/spectral elements. It is true that these methods give more accurate solution than their linear counterparts. However, numerically they are prohibitively expensive. Here we give a successful solution of this conflict by applying mass lumped higher order finite elements. This type of elements not only keep second/third order accuracy but also scale closely to linear elements by doing mass lumping. This is especially true for second order lump elements. Full M3D and anisotropic transport models are studied
Dimensionless Energy Conversion Characteristics of an Air-Powered Hydraulic Vehicle
Directory of Open Access Journals (Sweden)
Dongkai Shen
2018-02-01
Full Text Available Due to the advantages of resource conservation and less exhaust emissions, compressed air-powered vehicle has attracted more and more attention. To improve the power and efficiency of air-powered vehicle, an air-powered hydraulic vehicle was proposed. As the main part of the air-powered hydraulic vehicles, HP transformer (short for Hydropneumatic transformer is used to convert the pneumatic power to higher hydraulic power. In this study, to illustrate the energy conversion characteristics of air-powered hydraulic vehicle, dimensionless mathematical model of the vehicle’s working process was set up. Through experimental study on the vehicle, the dimensionless model was verified. Through simulation study on the vehicle, the following can be obtained: firstly, the increase of the hydraulic chamber orifice and the area ratio of the pistons can lead to a higher output power, while output pressure is just the opposite. Moreover, the increase of the output pressure and the aperture of the hydraulic chamber can lead to a higher efficiency, while area ratio of the pistons played the opposite role. This research can be referred to in the performance and design optimization of the HP transformers.
Mou, Jian; Hong, Guotong
2017-02-01
In this paper, the dimensionless power is used to optimize the free piston Stirling engines (FPSE). The dimensionless power is defined as a ratio of the heat power loss and the output work. The heat power losses include the losses of expansion space, heater, regenerator, cooler and the compression space and every kind of the heat loss calculated by empirical formula. The output work is calculated by the adiabatic model. The results show that 82.66% of the losses come from the expansion space and 54.59% heat losses of expansion space come from the shuttle loss. At different pressure the optimum bore-stroke ratio, heat source temperature, phase angle and the frequency have different values, the optimum phase angles increase with the increase of pressure, but optimum frequencies drop with the increase of pressure. However, no matter what the heat source temperature, initial pressure and frequency are, the optimum ratios of piston stroke and displacer stroke all about 0.8. The three-dimensional diagram is used to analyse Stirling engine. From the three-dimensional diagram the optimum phase angle, frequency and heat source temperature can be acquired at the same time. This study offers some guides for the design and optimization of FPSEs.
Comparing Jupiter and Saturn: dimensionless input rates from plasma sources within the magnetosphere
Directory of Open Access Journals (Sweden)
V. M. Vasyliūnas
2008-06-01
Full Text Available The quantitative significance for a planetary magnetosphere of plasma sources associated with a moon of the planet can be assessed only by expressing the plasma mass input rate in dimensionless form, as the ratio of the actual mass input to some reference value. Traditionally, the solar wind mass flux through an area equal to the cross-section of the magnetosphere has been used. Here I identify another reference value of mass input, independent of the solar wind and constructed from planetary parameters alone, which can be shown to represent a mass input sufficiently large to prevent corotation already at the source location. The source rate from Enceladus at Saturn has been reported to be an order of magnitude smaller (in absolute numbers than that from Io at Jupiter. Both reference values, however, are also smaller at Saturn than at Jupiter, by factors ~40 to 60; expressed in dimensionless form, the estimated mass input from Enceladus may be larger than that from Io by factors ~4 to 6. The magnetosphere of Saturn may thus, despite a lower mass input in kg s^{−1}, intrinsically be more heavily mass-loaded than the magnetosphere of Jupiter.
Comparing Jupiter and Saturn: dimensionless input rates from plasma sources within the magnetosphere
Directory of Open Access Journals (Sweden)
V. M. Vasyliūnas
2008-06-01
Full Text Available The quantitative significance for a planetary magnetosphere of plasma sources associated with a moon of the planet can be assessed only by expressing the plasma mass input rate in dimensionless form, as the ratio of the actual mass input to some reference value. Traditionally, the solar wind mass flux through an area equal to the cross-section of the magnetosphere has been used. Here I identify another reference value of mass input, independent of the solar wind and constructed from planetary parameters alone, which can be shown to represent a mass input sufficiently large to prevent corotation already at the source location. The source rate from Enceladus at Saturn has been reported to be an order of magnitude smaller (in absolute numbers than that from Io at Jupiter. Both reference values, however, are also smaller at Saturn than at Jupiter, by factors ~40 to 60; expressed in dimensionless form, the estimated mass input from Enceladus may be larger than that from Io by factors ~4 to 6. The magnetosphere of Saturn may thus, despite a lower mass input in kg s−1, intrinsically be more heavily mass-loaded than the magnetosphere of Jupiter.
Lump solutions and interaction phenomenon to the third-order nonlinear evolution equation
Kofane, T. C.; Fokou, M.; Mohamadou, A.; Yomba, E.
2017-11-01
In this work, the lump solution and the kink solitary wave solution from the (2 + 1) -dimensional third-order evolution equation, using the Hirota bilinear method are obtained through symbolic computation with Maple. We have assumed that the lump solution is centered at the origin, when t = 0 . By considering a mixing positive quadratic function with exponential function, as well as a mixing positive quadratic function with hyperbolic cosine function, interaction solutions like lump-exponential and lump-hyperbolic cosine are presented. A completely non-elastic interaction between a lump and kink soliton is observed, showing that a lump solution can be swallowed by a kink soliton.
Fundamentals of electromagnetics 1 internal behavior of lumped elements
Voltmer, David
2007-01-01
This book is the first of two volumes which have been created to provide an understanding of the basic principles and applications of electromagnetic fields for electrical engineering students. Fundamentals of Electromagnetics Vol 1: Internal Behavior of Lumped Elements focuses upon the DC and low-frequency behavior of electromagnetic fields within lumped elements. The properties of electromagnetic fields provide the basis for predicting the terminal characteristics of resistors, capacitors, and inductors. The properties of magnetic circuits are included as well. For slightly higher frequencie
Lumped parameter models for the interpretation of environmental tracer data
International Nuclear Information System (INIS)
Maloszewski, P.; Zuber, A.
1996-01-01
Principles of the lumped-parameter approach to the interpretation of environmental tracer data are given. The following models are considered: the piston flow model (PFM), exponential flow model (EM), linear model (LM), combined piston flow and exponential flow model (EPM), combined linear flow and piston flow model (LPM), and dispersion model (DM). The applicability of these models for the interpretation of different tracer data is discussed for a steady state flow approximation. Case studies are given to exemplify the applicability of the lumped-parameter approach. Description of a user-friendly computer program is given. (author). 68 refs, 25 figs, 4 tabs
Assessment of Lumped-Parameter Models for Rigid Footings
DEFF Research Database (Denmark)
Andersen, Lars
2010-01-01
The quality of consistent lumped-parameter models of rigid footings is examined. Emphasis is put on the maximum response during excitation and the geometrical damping related to free vibrations. The optimal order of a lumped-parameter model is determined for each degree of freedom, i.e. horizontal...... and vertical translations as well as torsion and rocking, and the necessity of coupling between horizontal sliding and rocking is discussed. Most of the analyses are carried out for hexagonal footings; but in order to generalise the conclusions to a broader variety of footings, comparisons are made...... with the response of circular and square foundations....
Directory of Open Access Journals (Sweden)
S. P. Seibert
2017-06-01
Full Text Available The baffling diversity of runoff generation processes, alongside our sketchy understanding of how physiographic characteristics control fundamental hydrological functions of water collection, storage, and release, continue to pose major research challenges in catchment hydrology. Here, we propose innovative data-driven diagnostic signatures for overcoming the prevailing status quo in catchment inter-comparison. More specifically, we present dimensionless double mass curves (dDMC which allow inference of information on runoff generation and the water balance at the seasonal and annual timescales. By separating the vegetation and winter periods, dDMC furthermore provide information on the role of biotic and abiotic controls in seasonal runoff formation. A key aspect we address in this paper is the derivation of dimensionless expressions of fluxes which ensure the comparability of the signatures in space and time. We achieve this by using the limiting factors of a hydrological process as a scaling reference. We show that different references result in different diagnostics. As such we define two kinds of dDMC which allow us to derive seasonal runoff coefficients and to characterize dimensionless streamflow release as a function of the potential renewal rate of the soil storage. We expect these signatures for storage controlled seasonal runoff formation to remain invariant, as long as the ratios of release over supply and supply over storage capacity develop similarly in different catchments. We test the proposed methods by applying them to an operational data set comprising 22 catchments (12–166 km2 from different environments in southern Germany and hydrometeorological data from 4 hydrological years. The diagnostics are used to compare the sites and to reveal the dominant controls on runoff formation. The key findings are that dDMC are meaningful signatures for catchment runoff formation at the seasonal to annual scale and that the type of
Seibert, Simon Paul; Jackisch, Conrad; Ehret, Uwe; Pfister, Laurent; Zehe, Erwin
2017-06-01
The baffling diversity of runoff generation processes, alongside our sketchy understanding of how physiographic characteristics control fundamental hydrological functions of water collection, storage, and release, continue to pose major research challenges in catchment hydrology. Here, we propose innovative data-driven diagnostic signatures for overcoming the prevailing status quo in catchment inter-comparison. More specifically, we present dimensionless double mass curves (dDMC) which allow inference of information on runoff generation and the water balance at the seasonal and annual timescales. By separating the vegetation and winter periods, dDMC furthermore provide information on the role of biotic and abiotic controls in seasonal runoff formation. A key aspect we address in this paper is the derivation of dimensionless expressions of fluxes which ensure the comparability of the signatures in space and time. We achieve this by using the limiting factors of a hydrological process as a scaling reference. We show that different references result in different diagnostics. As such we define two kinds of dDMC which allow us to derive seasonal runoff coefficients and to characterize dimensionless streamflow release as a function of the potential renewal rate of the soil storage. We expect these signatures for storage controlled seasonal runoff formation to remain invariant, as long as the ratios of release over supply and supply over storage capacity develop similarly in different catchments. We test the proposed methods by applying them to an operational data set comprising 22 catchments (12-166 km2) from different environments in southern Germany and hydrometeorological data from 4 hydrological years. The diagnostics are used to compare the sites and to reveal the dominant controls on runoff formation. The key findings are that dDMC are meaningful signatures for catchment runoff formation at the seasonal to annual scale and that the type of scaling strongly
Lumped conceptual hydrological model for Purna river basin, India
Indian Academy of Sciences (India)
graphical information system (GIS) based hydrological models are becoming increasingly useful in prediction of ... models are preferred over lumped conceptual models in prediction of runoff provided exten- sive data ..... high values of CQOF may be ascribed due to presence of certain low permeable soil like clay and bare ...
Primary Breast Tuberculosis Presenting as a Lump: A Rare Modern ...
African Journals Online (AJOL)
mammary area. A 25. year.old female, presented with a lump in the breast and infra.mammary area. She was having off and on fever without any other complaints. There was no positive family history. Primary breast tuberculosis was diagnosed on fine ...
Experimental realization of optical lumped nanocircuits at infrared wavelengths.
Sun, Yong; Edwards, Brian; Alù, Andrea; Engheta, Nader
2012-01-29
The integration of radiofrequency electronic methodologies on micro- as well as nanoscale platforms is crucial for information processing and data-storage technologies. In electronics, radiofrequency signals are controlled and manipulated by 'lumped' circuit elements, such as resistors, inductors and capacitors. In earlier work, we theoretically proposed that optical nanostructures, when properly designed and judiciously arranged, could behave as nanoscale lumped circuit elements--but at optical frequencies. Here, for the first time we experimentally demonstrate a two-dimensional optical nanocircuit at mid-infrared wavelengths. With the guidance of circuit theory, we design and fabricate arrays of Si3N4 nanorods with specific deep subwavelength cross-sections, quantitatively evaluate their equivalent impedance as lumped circuit elements in the mid-infrared regime, and by Fourier transform infrared spectroscopy show that these nanostructures can indeed function as two-dimensional optical lumped circuit elements. We further show that the connections among nanocircuit elements, in particular whether they are in series or in parallel combination, can be controlled by the polarization of impinging optical signals, realizing the notion of 'stereo-circuitry' in metatronics-metamaterials-inspired optical circuitry.
CASE REPORT Unusual cause of breast lump: a CSF pseudocyst
African Journals Online (AJOL)
A breast lump is an uncommon occurrence in the paediatric and adolescent patient;1 a majority of cases are either related to endocrine function or benign masses.2. The common benign causes are gynaecomastia, simple cyst, fibroadenoma, lymphnode, galactocoele, duct ectasia and infection.1 Malignant lesions are ...
Application of Biologically-Based Lumping To Investigate the ...
People are often exposed to complex mixtures of environmental chemicals such as gasoline, tobacco smoke, water contaminants, or food additives. However, investigators have often considered complex mixtures as one lumped entity. Valuable information can be obtained from these experiments, though this simplification provides little insight into the impact of a mixture's chemical composition on toxicologically-relevant metabolic interactions that may occur among its constituents. We developed an approach that applies chemical lumping methods to complex mixtures, in this case gasoline, based on biologically relevant parameters used in physiologically-based pharmacokinetic (PBPK) modeling. Inhalation exposures were performed with rats to evaluate performance of our PBPK model. There were 109 chemicals identified and quantified in the vapor in the chamber. The time-course kinetic profiles of 10 target chemicals were also determined from blood samples collected during and following the in vivo experiments. A general PBPK model was used to compare the experimental data to the simulated values of blood concentration for the 10 target chemicals with various numbers of lumps, iteratively increasing from 0 to 99. Large reductions in simulation error were gained by incorporating enzymatic chemical interactions, in comparison to simulating the individual chemicals separately. The error was further reduced by lumping the 99 non-target chemicals. Application of this biologic
Leaks, Lumps, and Lines: Stigma and Women's Bodies
Chrisler, Joan C.
2011-01-01
Women's bodies have often been positioned in art and popular culture as monstrous or defiled and women's bodily products (e.g., menstrual fluid, breast milk) as disgusting. This framing has led to the stigmatization of aspects of women's bodies (e.g., leaking fluids, lumps of fat, and lines in the skin that indicate aging), especially those…
High convergence order finite elements with lumped mass matrix
DEFF Research Database (Denmark)
Jensen, Morten skårup
1996-01-01
A method for deriving hexahedral finite elements with lumped mass matrices for three-dimensional problems is presented. These elements meet the theoretical conditions for high order convergence, and two numerical examples based on the three-dimensional scalar wave equation show that this is also...... the case in practice and that their accuracy is comparable to elements with consistent mass matrices....
WATGIS: A GIS-Based Lumped Parameter Water Quality Model
Glenn P. Fernandez; George M. Chescheir; R. Wayne Skaggs; Devendra M. Amatya
2002-01-01
A Geographic Information System (GIS)Âbased, lumped parameter water quality model was developed to estimate the spatial and temporal nitrogenÂloading patterns for lower coastal plain watersheds in eastern North Carolina. The model uses a spatially distributed delivery ratio (DR) parameter to account for nitrogen retention or loss along a drainage network. Delivery...
Lump Sum Moving Cost and Aggregate Office Space Use
G. Romijn
1997-01-01
textabstractWhen firms decide to change office space use, in many instances this involves relocation. Relocation involves sizable costs to the firm that can to a large extent be characterized as lump sum, i.e. independent of the change in demand. In this paper we propose and solve a model of the
Fine needle aspiration cytology of breast lumps with histopathologic ...
African Journals Online (AJOL)
Objective: To determine the histopathologic correlation of fine needle aspiration cytology FNAC of breast masses seen in the department of histopathology of the Federal Medical Center Owo, Southwestern Nigeria. Design: This is a 5-year retrospective study of breast lumps seen at Department of Histopathology, Federal ...
Intermittent reservoir daily-inflow prediction using lumped and ...
Indian Academy of Sciences (India)
In this study, multi-linear regression (MLR) approach is used to construct intermittent reservoir daily inflow forecasting system. To illustrate the applicability and effect of using lumped and distributed input data in MLR approach, Koyna river watershed in Maharashtra, India is chosen as a case study. The results are also ...
Lumped impulses, discrete displacements and a moving load analysis
Kok, A.W.M.
1997-01-01
Finite element models are usually presented as relations between lumped forces and discrete displacements. Mostly finite element models are found by the elaboration of the method of the virtual work - which is a special case of the Galerkin's variational principle -. By application of Galerkin's
Lumped conceptual hydrological model for Purna river basin, India
Indian Academy of Sciences (India)
Home; Journals; Sadhana; Volume 40; Issue 8 ... Conceptual hydrological NAM model; calibration; sensitivity analysis; validation; Tapi basin; Purna catchment. ... In present study, a lumped conceptual hydrological model, NAM (MIKE11), is calibrated while optimizing the runoff simulations on the basis of minimization of ...
Schmitz, Guy; Kolar-Anić, Ljiljana Z; Anić, Slobodan R; Cupić, Zeljko D
2008-12-25
The stoichiometric network analysis (SNA) introduced by B. L. Clarke is applied to a simplified model of the complex oscillating Bray-Liebhafsky reaction under batch conditions, which was not examined by this method earlier. This powerful method for the analysis of steady-states stability is also used to transform the classical differential equations into dimensionless equations. This transformation is easy and leads to a form of the equations combining the advantages of classical dimensionless equations with the advantages of the SNA. The used dimensionless parameters have orders of magnitude given by the experimental information about concentrations and currents. This simplifies greatly the study of the slow manifold and shows which parameters are essential for controlling its shape and consequently have an important influence on the trajectories. The effectiveness of these equations is illustrated on two examples: the study of the bifurcations points and a simple sensitivity analysis, different from the classical one, more based on the chemistry of the studied system.
Lumping procedure for a kinetic model of catalytic naphtha reforming
Directory of Open Access Journals (Sweden)
H. M. Arani
2009-12-01
Full Text Available A lumping procedure is developed for obtaining kinetic and thermodynamic parameters of catalytic naphtha reforming. All kinetic and deactivation parameters are estimated from industrial data and thermodynamic parameters are calculated from derived mathematical expressions. The proposed model contains 17 lumps that include the C6 to C8+ hydrocarbon range and 15 reaction pathways. Hougen-Watson Langmuir-Hinshelwood type reaction rate expressions are used for kinetic simulation of catalytic reactions. The kinetic parameters are benchmarked with several sets of plant data and estimated by the SQP optimization method. After calculation of deactivation and kinetic parameters, plant data are compared with model predictions and only minor deviations between experimental and calculated data are generally observed.
Lumped parametric model of the human ear for sound transmission.
Feng, Bin; Gan, Rong Z
2004-09-01
A lumped parametric model of the human auditoria peripherals consisting of six masses suspended with six springs and ten dashpots was proposed. This model will provide the quantitative basis for the construction of a physical model of the human middle ear. The lumped model parameters were first identified using published anatomical data, and then determined through a parameter optimization process. The transfer function of the middle ear obtained from human temporal bone experiments with laser Doppler interferometers was used for creating the target function during the optimization process. It was found that, among 14 spring and dashpot parameters, there were five parameters which had pronounced effects on the dynamic behaviors of the model. The detailed discussion on the sensitivity of those parameters was provided with appropriate applications for sound transmission in the ear. We expect that the methods for characterizing the lumped model of the human ear and the model parameters will be useful for theoretical modeling of the ear function and construction of the ear physical model.
A Quasi-Lumped Element Series Array Resonator Antenna
Directory of Open Access Journals (Sweden)
S. S. Olokede
2015-09-01
Full Text Available This paper presents a 6-element series array quasi-lumped element resonator antenna. The proposed antenna employs an interdigital capacitor in parallel with a straight strip conductor whose centre finger is shorted across the capacitor. An array configuration is imperative as the gain of a single quasi-lumped element arrangement was only moderate and specifically put at about 9.4 dBi which may not be adequate for long distance communications. Relevant Equations for radiation pattern of the quasi-lumped element resonator (QLER were derived and presented. The proposed antenna array exhibits a gain enhancement up to about 29.47% with a noticed size reduction of 80 × 30 sq. mm. Compared to standard long wire antenna and other approaches of capacitive loaded long wire antennas, it was proved that the proposed antenna has a relatively better performance yet with significant size reduction. Consequently, it is an ideal candidate for MMIC designs and wireless communication applications.
THE DIMENSIONLESS AGE OF THE UNIVERSE: A RIDDLE FOR OUR TIME
Energy Technology Data Exchange (ETDEWEB)
Avelino, Arturo; Kirshner, Robert P., E-mail: aavelino@cfa.harvard.edu [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, Massachusetts, 02138 (United States)
2016-09-01
We present the interesting coincidence of cosmology and astrophysics that points toward a dimensionless age of the Universe H {sub 0} t {sub 0} that is close to one. Despite cosmic deceleration for 9 Gyr and acceleration since then, we find H {sub 0} t {sub 0} = 0.96 ± 0.01 for the ΛCDM model that fits SN Ia data from Pan-STARRS, CMB power spectra, and baryon acoustic oscillations. Similarly, astrophysical measures of stellar ages and the Hubble constant derived from redshifts and distances point to H {sub 0} t ∼ 1.0 ± 0.1. The wide range of possible values for H {sub 0} t {sub 0} realized during cosmic evolution means that we live at what appears to be a special time. This “synchronicity problem” is not precisely the same as the usual coincidence problem , because there are combinations of Ω{sub M} and Ω{sub Λ} for which the usual coincidence problem holds but for which H {sub 0} t {sub 0} is not close to 1.
Niblett, Daniel; Porter, Stuart; Reynolds, Gavin; Morgan, Tomos; Greenamoyer, Jennifer; Hach, Ronald; Sido, Stephanie; Karan, Kapish; Gabbott, Ian
2017-08-07
A mathematical, mechanistic tablet film-coating model has been developed for pharmaceutical pan coating systems based on the mechanisms of atomisation, tablet bed movement and droplet drying with the main purpose of predicting tablet appearance quality. Two dimensionless quantities were used to characterise the product properties and operating parameters: the dimensionless Spray Flux (relating to area coverage of the spray droplets) and the Niblett Number (relating to the time available for drying of coating droplets). The Niblett Number is the ratio between the time a droplet needs to dry under given thermodynamic conditions and the time available for the droplet while on the surface of the tablet bed. The time available for drying on the tablet bed surface is critical for appearance quality. These two dimensionless quantities were used to select process parameters for a set of 22 coating experiments, performed over a wide range of multivariate process parameters. The dimensionless Regime Map created can be used to visualise the effect of interacting process parameters on overall tablet appearance quality and defects such as picking and logo bridging. Copyright © 2017 Elsevier B.V. All rights reserved.
Garavaglia, Federico; Le Lay, Matthieu; Gottardi, Fréderic; Garçon, Rémy; Gailhard, Joël; Paquet, Emmanuel; Mathevet, Thibault
2017-08-01
Model intercomparison experiments are widely used to investigate and improve hydrological model performance. However, a study based only on runoff simulation is not sufficient to discriminate between different model structures. Hence, there is a need to improve hydrological models for specific streamflow signatures (e.g., low and high flow) and multi-variable predictions (e.g., soil moisture, snow and groundwater). This study assesses the impact of model structure on flow simulation and hydrological realism using three versions of a hydrological model called MORDOR: the historical lumped structure and a revisited formulation available in both lumped and semi-distributed structures. In particular, the main goal of this paper is to investigate the relative impact of model equations and spatial discretization on flow simulation, snowpack representation and evapotranspiration estimation. Comparison of the models is based on an extensive dataset composed of 50 catchments located in French mountainous regions. The evaluation framework is founded on a multi-criterion split-sample strategy. All models were calibrated using an automatic optimization method based on an efficient genetic algorithm. The evaluation framework is enriched by the assessment of snow and evapotranspiration modeling against in situ and satellite data. The results showed that the new model formulations perform significantly better than the initial one in terms of the various streamflow signatures, snow and evapotranspiration predictions. The semi-distributed approach provides better calibration-validation performance for the snow cover area, snow water equivalent and runoff simulation, especially for nival catchments.
International Nuclear Information System (INIS)
Ozgener, B.; Azgener, H.A.
1991-01-01
In finite element formulations for the solution of the within-group neutron diffusion equation, two different treatments are possible for the group source term: the consistent source approximation (CSA) and the lumped source approximation (LSA). CSA results in intra-group scattering and fission matrices which have the same nondiagonal structure as the global coefficient matrix. This situation might be regarded as a disadvantage, compared to the conventional (i.e. finite difference) methods where the intra-group scattering and fission matrices are diagonal. To overcome this disadvantage, LSA could be used to diagonalize these matrices. LSA is akin to the lumped mass approximation of continuum mechanics. We concentrate on two different aspects of the source approximations. Although it has been reported that LSA does not modify the asymptotic h 2 convergence behaviour for linear elements, the effect of LSA on convergence of higher degree elements has not been investigated. Thus, we would be interested in determining, p, the asymptotic order of convergence, in: Δk |k eff (analytical) -k eff (finite element)| = Ch p (1) for finite element approximations of varying degree (N) with both of the source approximations. Since (1) is valid in the asymptotic limit, we must use ultra-fine meshes and quadruple precision arithmetic. For our order of convergence study, we used infinite cylindrical geometry with azimuthal symmetry. Hence, the effects of singularities remain uninvestigated. The second aspect we dwell on is the performance of LSA in bilinear 3-D finite element calculations, compared to CSA. LSA has been used quite extensively in 1- and 2-D even-parity transport and diffusion calculations. In this work, we will try to assess the relative merits of LSA and CSA in 3-D problems. (author)
New equivalent lumped electrical circuit for piezoelectric transformers.
Gonnard, Paul; Schmitt, P M; Brissaud, Michel
2006-04-01
A new equivalent circuit is proposed for a contour-vibration-mode piezoelectric transformer (PT). It is shown that the usual lumped equivalent circuit derived from the conventional Mason approach is not accurate. The proposed circuit, built on experimental measurements, makes an explicit difference between the elastic energies stored respectively on the primary and secondary parts. The experimental and theoretical resonance frequencies with the secondary in open or short circuit are in good agreement as well as the output "voltage-current" characteristic and the optimum efficiency working point. This circuit can be extended to various PT configurations and appears to be a useful tool for modeling electronic devices that integrate piezoelectric transformers.
A lumped model for rotational modes in periodic solid composites
Peng, Pai
2013-10-01
We present a lumped model to study the rotational modes in a type of two-dimensional periodic solid composites comprised of a square array of rubber-coated steel cylinders embedded in an epoxy matrix. The model captures the physical essence of rotational modes in such systems for various combinations of material parameters, and, therefore it is able to describe the transition behaviour when the system is gradually adjusted from an elastic metamaterial to an elastic phononic crystal. From the model, we can define a transition zone which separates the typical elastic metamaterials and the phononic crystals.
Lumped-parameter fuel rod model for rapid thermal transients
International Nuclear Information System (INIS)
Perkins, K.R.; Ramshaw, J.D.
1975-07-01
The thermal behavior of fuel rods during simulated accident conditions is extremely sensitive to the heat transfer coefficient which is, in turn, very sensitive to the cladding surface temperature and the fluid conditions. The development of a semianalytical, lumped-parameter fuel rod model which is intended to provide accurate calculations, in a minimum amount of computer time, of the thermal response of fuel rods during a simulated loss-of-coolant accident is described. The results show good agreement with calculations from a comprehensive fuel-rod code (FRAP-T) currently in use at Aerojet Nuclear Company
Lump Sum Alternatives to Current Veterans’ Disability Compensation
2006-11-01
equivalent amount in the fu- ture. See the Glossary in Appendix A for more details. 4. Examples of non-economic losses are pain , suffering, and lower...are non-taxable. The lump sum payment is for “ pain and suffering” and non- economic losses that are a result of the service-connected disability. The...6% 4.1% 17 Spine 249,174 18% 5.2% 20 Skull 7,890 1% 0.4% * Ribs 2,032 0% 0.4% * Coccyx 527 0% 1.3% * Other skeletal conditions 83,456 6% 3.2% 16
Bayiz, Yagiz Efe; Ghanaatpishe, Mohammad; Fathy, Hosam; Cheng, Bo
2018-03-20
In this work, a multi-objective optimization framework is developed for optimizing low-Reynolds number (Re) hovering flight. This framework is then applied to compare the efficiency of rigid revolving and flapping wings with rectangular shape under varying Re and Rossby number (Ro, or aspect ratio). The proposed framework is capable of generating sets of optimal solutions and Pareto fronts for maximizing lift coefficient and minimizing power coefficient in dimensionless space, which explicitly reveal the trade off between lift generation and power consumption. The results indicate that revolving wings are more efficient if the required average lift coefficient CL is low (< 1 for Re = 100 and < 1.6 for Re = 8000), while flapping wings are more efficient in achieving higher CL. Using dimensionless power loading as the single objective performance measure to be maximized, rotary flight is more efficient than flapping wings for Re > 100 regardless of the amount of energy storage assumed in the flapping-wing actuation mechanism, while flapping flight becomes more efficient for Re < 100. It is observed that wings with low Ro perform better if higher CL is needed, whereas higher Ro cases are more efficient at CL < 0.9 region. However, for the selected geometry and Re, the efficiency is weakly dependent on Ro if the dimensionless power loading is maximized. © 2018 IOP Publishing Ltd.
Optimum Design and Operation of Cyclic Storage Systems; Lumped Approach
Directory of Open Access Journals (Sweden)
Leila Ostadrahimi
2007-01-01
Full Text Available Conjunctive use of surface and groundwater resources is a preferred approach in water resources management. Compared to dam construction, groundwater has certain advantages, among which are less costs, less sedimentation and evaporation, fewer water quality problems, and less social and cultural problems. To reduce the major problems associated with the development of large-scale surface impoundment systems, cyclic storage systems can be used as an alternative. A cyclic storage system (CYCS is an integrated interactive system consisting of two subsystems of surface water storage (reservoir and groundwater; this system together with artificial recharge is able to satisfy the predefined demands with rather high reliability. In order to optimize these systems, one must consider the hydraulic interactions between all the components, but unfortunately it has been neglected in many studies. In this article, a nonlinear optimization model for design and operation of cyclic storage systems has been developed using the lumped approach. In order to evaluate the model, its results have been compared with the results of a model in which distributed approach had been deployed, and so the efficiency of lumped models to solve the problems of cyclic storage systems has been investigated.
Kuruvilla, K.; Kuruvilla, Anju
2010-01-01
Writing a ?Diagnostic Formulation? is a skill expected of candidates in the post-graduate examinations in psychiatry in most universities in India. However there is ambiguity regarding what the term means and how it should be written. This article is an attempt to provide some guidelines on this topic.
The lumping of heat transfer parameters in cooled packed beds: effect of the bed entry
Westerink, E.J.; Gerner, J.W.; Gerner, J.W.; Westerterp, K.R.; van der Wal, S.
1993-01-01
The lumping of the heat transfer parameters of the one- and the two-dimensional pseudo-homogeneous model of a cooled fixed bed were compared. It appeared that the lumping of the two-dimensional parameters, being the effective radial conductivity h-eff and the heat transfer coefficient at the wall
Emergence and space–time structure of lump solution to the (2+ 1 ...
Indian Academy of Sciences (India)
... parameter u 0 for the (2+1)-dimensional generalized Kadomtsev–Petviashvili equation. Based on the periodic breather-wave, a lump solution is emerged by limit behaviour. Finally, three different forms of the space–time structure of the lump solution are investigated and discussed using the extreme value theory.
29 CFR Appendix A to Part 4022 - Lump Sum Mortality Rates
2010-07-01
... 29 Labor 9 2010-07-01 2010-07-01 false Lump Sum Mortality Rates A Appendix A to Part 4022 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION COVERAGE AND BENEFITS BENEFITS PAYABLE IN TERMINATED SINGLE-EMPLOYER PLANS Pt. 4022, App. A Appendix A to Part 4022—Lump Sum Mortality...
Lump Solutions and Resonance Stripe Solitons to the (2+1-Dimensional Sawada-Kotera Equation
Directory of Open Access Journals (Sweden)
Xian Li
2017-01-01
Full Text Available Based on the symbolic computation, a class of lump solutions to the (2+1-dimensional Sawada-Kotera (2DSK equation is obtained through making use of its Hirota bilinear form and one positive quadratic function. These solutions contain six parameters, four of which satisfy two determinant conditions to guarantee the analyticity and rational localization of the solutions, while the others are free. Then by adding an exponential function into the original positive quadratic function, the interaction solutions between lump solutions and one stripe soliton are derived. Furthermore, by extending this method to a general combination of positive quadratic function and hyperbolic function, the interaction solutions between lump solutions and a pair of resonance stripe solitons are provided. Some figures are given to demonstrate the dynamical properties of the lump solutions, interaction solutions between lump solutions, and stripe solitons by choosing some special parameters.
Metastatic uterine leiomyosarcoma presenting as a breast lump.
LENUS (Irish Health Repository)
Sibartie, S
2009-01-31
BACKGROUND: It is uncommon to encounter a breast metastasis from an extramammary malignancy and even rarer from a uterine leiomyosarcoma. AIMS: We describe the third case report in the medical literature of a breast metastasis from a uterine leiomyosarcoma. METHODS: We report the management of a 56-year-old patient who presented with a breast lump 3 years after hysterectomy for a fibroid uterus. We conducted a literature review of breast leiomyosarcomas. RESULTS: The excision of the breast mass revealed a low-grade leiomyosarcoma. Radiographic examinations demonstrated metastases to the lung, liver, pelvis and bone. Retrospective pathology review of her uterus identified a small focus of leiomyosarcoma. She received chemotherapy and palliative radiotherapy but passed away within few months. CONCLUSION: Metastasis to the breast from a non-breast primary is generally a sign of disseminated disease and; thus, a poor prognostic indicator.
Lumped model for rotational modes in phononic crystals
Peng, Pai
2012-10-16
We present a lumped model for the rotational modes induced by the rotational motion of individual scatterers in two-dimensional phononic crystals comprised of square arrays of solid cylindrical scatterers in solid hosts. The model provides a physical interpretation of the origin of the rotational modes, reveals the important role played by the rotational motion in determining the band structure, and reproduces the dispersion relations in a certain range. The model increases the possibilities of manipulating wave propagation in phononic crystals. In particular, expressions derived from the model for eigenfrequencies at high symmetry points unambiguously predict the presence of a new type of Dirac-like cone at the Brillouin center, which is found to be the result of accidental degeneracy of the rotational and dipolar modes.
A lumped parameter, low dimension model of heat exchanger
International Nuclear Information System (INIS)
Kanoh, Hideaki; Furushoo, Junji; Masubuchi, Masami
1980-01-01
This paper reports on the results of investigation of the distributed parameter model, the difference model, and the model of the method of weighted residuals for heat exchangers. By the method of weighted residuals (MWR), the opposite flow heat exchanger system is approximated by low dimension, lumped parameter model. By assuming constant specific heat, constant density, the same form of tube cross-section, the same form of the surface of heat exchange, uniform flow velocity, the linear relation of heat transfer to flow velocity, liquid heat carrier, and the thermal insulation of liquid from outside, fundamental equations are obtained. The experimental apparatus was made of acrylic resin. The response of the temperature at the exit of first liquid to the variation of the flow rate of second liquid was measured and compared with the models. The MWR model shows good approximation for the low frequency region, and as the number of division increases, good approximation spreads to higher frequency region. (Kato, T.)
Czech Academy of Sciences Publication Activity Database
Frassinetti, L.; Saarelma, S.; Lomas, P.; Nunes, I.; Rimini, F.; Beurskens, M.N.A.; Bílková, Petra; Boom, J.E.; De La Luna, E.; Delabie, E.; Drewelow, P.; Flanagan, J.; Garzotti, L.; Giroud, C.; Hawks, N.; Joffrin, E.; Kempenaars, M.; Kim, H.-T.; Kruezi, U.; Loarte, A.; Lomanowski, B.; Lupelli, I.; Meneses, L.; Maggi, C.F.; Menmuir, S.; Peterka, Matěj; Rachlew, E.; Romanelli, M.; Stefanikova, E.
2017-01-01
Roč. 59, č. 1 (2017), č. článku 014014. ISSN 0741-3335. [EPS 2016: Conference on Plasma Physics/43./. Leuven, 04.07.2016-08.07.2016] EU Projects: European Commission(XE) 633053 - EUROfusion Institutional support: RVO:61389021 Keywords : JET-ILW * dimensionless scaling * pedestal * confinement * pedestal stability * heat transport Subject RIV: BL - Plasma and Gas Discharge Physics OBOR OECD: Fluids and plasma physics (including surface physics) Impact factor: 2.392, year: 2016 http://dx.doi.org/10.1088/0741-3335/59/1/014014
Agishev, Ravil R.; Comerón Tejero, Adolfo; Rodríguez Gómez, Alejandro Antonio; Sicard, Michaël
2014-01-01
In this paper, we show a renewed approach to the generalized methodology for atmospheric lidar assessment, which uses the dimensionless parameterization as a core component. It is based on a series of our previous works where the problem of universal parameterization over many lidar technologies were described and analyzed from different points of view. The modernized dimensionless parameterization concept applied to relatively new silicon photomultiplier detectors (SiPMs) and traditional pho...
Thomases, Becca; Guy, Robert
2015-11-01
The question of how fluid elasticity affects the swimming performance of micro-organisms is complicated and has been the subject of many recent experimental and theoretical studies. The Deborah number, De = λω , is typically used to characterize the strength of the fluid elasticity in these studies, and for swimmers is expressed as the product of the elastic relaxation time and the frequency of the swimmer stroke. In simulations of undulatory flexible swimmers in an Oldroyd-B-type fluid, we find that varying the frequency of the stroke and varying the relaxation time separately results in a significantly different dependence of swimming speed for the same De . Thus the elastic effects on swimming cannot be characterized by a single dimensionless number. The Weissenberg number, defined as the product of elastic relaxation time and characteristic strain rate (Wi = λγ˙), is another dimensionless parameter useful for describing complex fluids. For a fixed swimmer frequency, varying the relaxation time will also vary the Weissenberg number. We conjecture that the different behavior is a consequence of a Weissenberg-number transition in the fluid, which additionally depends on the amplitude of the swimmer stroke.
Topological lumps and Dirac zero modes in SU(3) lattice gauge theory on the torus
International Nuclear Information System (INIS)
Gattringer, Christof; Pullirsch, Rainer
2004-01-01
We compute eigenmodes of the lattice Dirac operator for quenched SU(3) gauge configurations on the 4-torus with topological charge ±1. We find a strong dependence of the zero modes on the boundary conditions which we impose for the Dirac operator. The lumps seen by the eigenmodes often change their position when changing the boundary conditions, while the local chirality of the lumps remains the same. Our results show that the zero mode of a charge ±1 configuration can couple to more than one object. We address the question whether these objects could be fractionally charged lumps
A correction technique for the dispersive effects of mass lumping for transport problems
Guermond, Jean-Luc
2013-01-01
This paper addresses the well-known dispersion effect that mass lumping induces when solving transport-like equations. A simple anti-dispersion technique based on the lumped mass matrix is proposed. The method does not require any non-trivial matrix inversion and has the same anti-dispersive effects as the consistent mass matrix. A novel quasi-lumping technique for P2 finite elements is introduced. Higher-order extensions of the method are also discussed. © 2012 Elsevier B.V.
PEMBELAJARAN SENI TARI KUDA LUMPING DI DESA DUKUHWALUH KECAMATAN KEMBARAN KAB. BANYUMAS
Directory of Open Access Journals (Sweden)
Daryanto Daryanto
2011-03-01
Full Text Available The goals this research were to determine: 1. What are the requirements given to prospective players of Kuda Lumping; 2. What material provided and what methods are used in training Kuda Lumping; 3. What is the cost required to conduct training of Kuda Lumping, and from which source. 4. How long does it take to produce players who are ready to perform Kuda Lumping showcased in front of an audience. From the research result shows that: 1. Requirements given to players of Kuda Lumping (Ebeg, are namely: (1 has Kuda Lumping, (2 can dance in group / compact dance, (3 perform the ritual bathing and diving in rivers and (4 conduct ”Ngasrep” or fasting for 3 (three days without stopping. 2. The practice material was first given to prospective players Kuda Lumping is dance. In practing the dance material, the new dancers were directly guided by the seniors. The method used is by giving examples of dancing by the senior players to prospective players. When giving examples accompanied by gamelan / music, while dancer candidates of Kuda Lumping followed. 3. Fee required for training activities at least IDR 400,000,- (four hundred thousand rupiah. This cost does not include the cost to buy a kuda lumping. Sources of cost comes from the self-help group members of kuda lumping, like dalang ( director of the dance and local people. It means the training and activities of Kuda Lumping, did not receive funding / donations from the government, both the village and district governments. The cost for training activities was used to rent the gamelan, to purchase clothing / costume players, “sesaji”, consumption and honorariums. 4. To train / produce, it take a player at least 3.5 (three and a half months and a maximum of 7 (seven months. This calculation is based on the starting time of dance exercise, until doing the bath in the river as the last stage. Key Wordsi: Kuda lumping, learning ,ngasrep, ritual of bathe, ritual offerings, wayang,
Optimization of lumping schemes for plane square quadratic finite element in elastodynamics
Directory of Open Access Journals (Sweden)
Kolman R.
2007-10-01
Full Text Available The effectiveness of explicit direct time-integration methods is conditioned by using diagonal mass matrix which entails significant computational savings and storage advantages. In recent years many procedures that produced diagonally lumped mass matrices were developed. For example, the row sum method and diagonal scaling method (HRZ procedure can be mentioned. In this paper, the dispersive properties of different lumping matrices with variable mass distribution for the plane square 8-node serendipity elements are investigated. The dispersion diagrams for such lumping matrices are derived for various Courant numbers, wavelengths and the directions of wave propagation.
Lump solutions with interaction phenomena in the (2+1)-dimensional Ito equation
Zou, Li; Yu, Zong-Bing; Tian, Shou-Fu; Feng, Lian-Li; Li, Jin
2018-03-01
In this paper, we consider the (2+1)-dimensional Ito equation, which was introduced by Ito. By considering the Hirota’s bilinear method, and using the positive quadratic function, we obtain some lump solutions of the Ito equation. In order to ensure rational localization and analyticity of these lump solutions, some sufficient and necessary conditions are provided on the parameters that appeared in the solutions. Furthermore, the interaction solutions between lump solutions and the stripe solitons are discussed by combining positive quadratic function with exponential function. Finally, the dynamic properties of these solutions are shown via the way of graphical analysis by selecting appropriate values of the parameters.
Directory of Open Access Journals (Sweden)
G. Iordanou
2011-10-01
Full Text Available This work describes the developed of a lumped parameter model and demonstrates its practical application. The lumped parameter mathematical model is a useful instrument to be used for rapid determination of design dimensions and operational performance of solar collectors at the designing stage. Such model which incorporates data from relevant Computational Fluid Dynamics design and experimental investigations can provide an acceptable accuracy in predictions and can be used as an effective design tool. A computer algorithm validates the lumped parameter model via a window environment program.
Combined finite difference-lumped modelling of fluid loaded Cmut arrays
Meynier, Cyril; Teston, Franck; Jeanne, Edgard; Bernard, Jean Edouard; Certon, Dominique
2010-01-01
This paper describes a model based on mixed finite-difference - lumped modeling to compute the frequency response of cMUTs in array element. Electrical impedance and laser interferometry measurements are presented and compared with theory.
People are often exposed to complex mixtures of environmental chemicals such as gasoline, tobacco smoke, water contaminants, or food additives. However, investigators have often considered complex mixtures as one lumped entity. Valuable information can be obtained from these exp...
Parameter Lumping Implications to Hydrologic Simulations of a Post-Glacial Landscape
Gerard, B.; Smith, S. M.; Reeve, A. S.; Roy, S. G.
2015-12-01
Even hydrologic models commonly described as being "fully distributed" require some degree of parameter lumping. This is typically necessary because of limited availability and resolution of watershed data, including precipitation, surface flows, soil distributions, land cover and drainage network hydraulic characteristics. The extent to which parameters are lumped is most often a decision made by the investigator with attention to research objectives, data availability, and model capabilities. Here we summarize the implications of parameter lumping to model efficiency using a distributed hydrologic simulation platform (MIKE SHE) applied to the Northwest River watershed in southern Maine, U.S.A. We compare parameter lumping effects on surface flows at the watershed outlet by varying the spatial scale (grid size), precipitation time step, computational time step, and agglomeration of landscape characteristics. The outcomes of these analyses are summarized relative to model efficiency with discussion of the implications to watershed management decisions and strategies.
Parameter Lumping Implications to Hydrologic Simulations in a Post-Glacial Landscape
Gerard, B.; Smith, S. M.; Reeve, A. S.; Martin, D.; Van Dam, B. M., Jr.
2014-12-01
Even hydrologic models commonly described as being "fully distributed" require some degree of parameter lumping. This is typically necessary because of limited availability and resolution of watershed data, including precipitation, surface flows, soil distributions, land cover and drainage network hydraulic characteristics. The extent to which parameters are lumped is most often a decision made by the investigator with attention to research objectives, data availability, and model capabilities. Here we summarize the implications of parameter lumping to model efficiency using a distributed hydrologic simulation platform (MIKE SHE) applied to the Northwest River watershed in southern Maine, U.S.A. We compare parameter lumping effects on surface flows at the watershed outlet by varying the spatial scale (grid size), precipitation time step, computational time step, and agglomeration of landscape characteristics. The outcomes of these analyses are summarized relative to model efficiency with discussion of the implications to watershed management decisions and strategies.
Uncovering and testing the fuzzy clusters based on lumped Markov chain in complex network.
Jing, Fan; Jianbin, Xie; Jinlong, Wang; Jinshuai, Qu
2013-01-01
Identifying clusters, namely groups of nodes with comparatively strong internal connectivity, is a fundamental task for deeply understanding the structure and function of a network. By means of a lumped Markov chain model of a random walker, we propose two novel ways of inferring the lumped markov transition matrix. Furthermore, some useful results are proposed based on the analysis of the properties of the lumped Markov process. To find the best partition of complex networks, a novel framework including two algorithms for network partition based on the optimal lumped Markovian dynamics is derived to solve this problem. The algorithms are constructed to minimize the objective function under this framework. It is demonstrated by the simulation experiments that our algorithms can efficiently determine the probabilities with which a node belongs to different clusters during the learning process and naturally supports the fuzzy partition. Moreover, they are successfully applied to real-world network, including the social interactions between members of a karate club.
Ammar, M I; Oeppen, R S; Bowles, C; Brennan, P A
2017-11-01
While a neck lump is a common presentation that can raise suspicion of a potentially serious underlying disease, a hard lump, though less common, may be even more concerning for the patient, and prompt urgent investigation. Metastatic squamous cell carcinoma is the commonest underlying diagnosis that must be excluded, but other diseases or even normal anatomy of the neck can be associated with lumps that are hard or bony. Many of these presentations are relatively rare and may not be familiar to oral and maxillofacial surgeons (OMFS) (particularly more junior clinicians) as a differential diagnosis of a hard neck mass. We have reviewed these lesions to raise awareness of possible unusual causes, particularly when patients are not initially examined in a specialist neck lump clinic where ultrasound is readily available. Copyright © 2017 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
Schuster, H; Agada, F O; Anderson, A R; Jackson, R S; Blair, D; McGann, H; Kelly, G
2007-02-01
A 29 year-old Nigerian studying in the UK presented with a neck lump and otitis media. Paragonimus-like trematode eggs were found in the neck lump aspirate. Morphologically these eggs resembled Paragonimus uterobilateralis or Achillurbainia congolensis. We favoured the diagnosis of achillurbainiasis over extrapulmonary paragonimiasis on the basis of clinical features and because we could not amplify DNA sequences using PCR primers specific for Paragonimus species. We discuss current diagnostic challenges for this rare parasitic infection.
Some error estimates for the lumped mass finite element method for a parabolic problem
Chatzipantelidis, P.
2012-01-01
We study the spatially semidiscrete lumped mass method for the model homogeneous heat equation with homogeneous Dirichlet boundary conditions. Improving earlier results we show that known optimal order smooth initial data error estimates for the standard Galerkin method carry over to the lumped mass method whereas nonsmooth initial data estimates require special assumptions on the triangulation. We also discuss the application to time discretization by the backward Euler and Crank-Nicolson methods. © 2011 American Mathematical Society.
The H-mode pedestal, ELMs and TF ripple effects in JT-60U/JET dimensionless identity experiments
International Nuclear Information System (INIS)
Saibene, G.; Oyama, N.; Loennroth, J.; Andrew, Y.; Luna, E. de la; Giroud, C.; Huysmans, G.T.A.; Kamada, Y.; Kempenaars, M.A.H.; Loarte, A.; Donald, D. Mc; Nave, M.M.F.; Meiggs, A.; Parail, V.; Sartori, R.; Sharapov, S.; Stober, J.; Suzuki, T.; Takechi, M.; Toi, K.; Urano, H.
2007-01-01
This paper summarizes results of dimensionless identity experiments in JT-60U and JET, aimed at the comparison of the H-mode pedestal and ELM behaviour in the two devices. Given their similar size, dimensionless matched plasmas are also similar in their dimensional parameters (in particular, the plasma minor radius a is the same in JET and JT-60U). Power and density scans were carried out at two values of I p , providing a q scan (q 95 = 3.1 and 5.1) with fixed (and matched) toroidal field. Contrary to initial expectations, a dimensionless match between the two devices was quite difficult to achieve. In general, p ped in JT-60U is lower than in JET and, at low q, the pedestal pressure of JT-60U with a Type I ELMy edge is matched in JET only in the Type III ELM regime. At q 95 = 5.1, a dimensionless match in ρ*, ν* and β p,ped is obtained with Type I ELMs, but only with low power JET H-modes. These results motivated a closer investigation of experimental conditions in the two devices, to identify possible 'hidden' physics that prevents obtaining a good match of pedestal values over a large range of plasmas parameters. Ripple-induced ion losses of the medium bore plasma used in JT-60U for the similarity experiments are identified as the main difference with JET. The magnitude of the JT-60U ripple losses is sufficient to induce counter-toroidal rotation in co-injected plasma. The influence of ripple losses was demonstrated at q 95 = 5.1: reducing ripple losses by ∼2 (from 4.3 to 1.9 MW) by replacing positive with negative neutral beam injection at approximately constant P in resulted in an increased p ped in JT-60U, providing a good match to full power JET H-modes. At the same time, the counter-toroidal rotation decreased. Physics mechanisms relating ripple losses to pedestal performance are not yet identified, and the possible role of velocity shear in the pedestal stability, as well as the possible influence of ripple on thermal ion transport are briefly
Lump Solutions and Interaction Phenomenon for (2+1)-Dimensional Sawada–Kotera Equation
Huang, Li-Li; Chen, Yong
2017-05-01
In this paper, a class of lump solutions to the (2+1)-dimensional Sawada–Kotera equation is studied by searching for positive quadratic function solutions to the associated bilinear equation. To guarantee rational localization and analyticity of the lumps, some sufficient and necessary conditions are presented on the parameters involved in the solutions. Then, a completely non-elastic interaction between a lump and a stripe of the (2+1)-dimensional Sawada–Kotera equation is obtained, which shows a lump solution is drowned or swallowed by a stripe soliton. Finally, 2-dimensional curves, 3-dimensional plots and density plots with particular choices of the involved parameters are presented to show the dynamic characteristics of the obtained lump and interaction solutions. Supported by the Global Change Research Program of China under Grant No. 2015CB953904, National Natural Science Foundation of China under Grant Nos. 11675054 and 11435005, Outstanding Doctoral Dissertation Cultivation Plan of Action under Grant No. YB2016039, and Shanghai Collaborative Innovation Center of Trustworthy Software for Internet of Things under Grant No. ZF1213
Jasper, Micah N; Martin, Sheppard A; Oshiro, Wendy M; Ford, Jermaine; Bushnell, Philip J; El-Masri, Hisham
2016-03-15
People are often exposed to complex mixtures of environmental chemicals such as gasoline, tobacco smoke, water contaminants, or food additives. We developed an approach that applies chemical lumping methods to complex mixtures, in this case gasoline, based on biologically relevant parameters used in physiologically based pharmacokinetic (PBPK) modeling. Inhalation exposures were performed with rats to evaluate the performance of our PBPK model and chemical lumping method. There were 109 chemicals identified and quantified in the vapor in the chamber. The time-course toxicokinetic profiles of 10 target chemicals were also determined from blood samples collected during and following the in vivo experiments. A general PBPK model was used to compare the experimental data to the simulated values of blood concentration for 10 target chemicals with various numbers of lumps, iteratively increasing from 0 to 99. Large reductions in simulation error were gained by incorporating enzymatic chemical interactions, in comparison to simulating the individual chemicals separately. The error was further reduced by lumping the 99 nontarget chemicals. The same biologically based lumping approach can be used to simplify any complex mixture with tens, hundreds, or thousands of constituents.
Directory of Open Access Journals (Sweden)
Adams Simon T
2009-03-01
Full Text Available Abstract Introduction Silicone lymphadenopathy is a rare but recognised complication of procedures involving the use of silicone. It has a poorly understood mechanism but is thought to occur following the transportation of silicone particles from silicone-containing prostheses to lymph nodes by macrophages. Case presentation We report of a case involving a 35-year-old woman who presented to the breast clinic with a breast lump and altered sensation below her left nipple 5 years after bilateral cosmetic breast augmentations. A small lump was detected inferior to the nipple but clinical examination and initial ultrasound investigation showed both implants to be intact. However, mammography and magnetic resonance imaging of both breasts revealed both intracapsular and extracapsular rupture of the left breast prosthesis. The patient went on to develop a flu-like illness and tender lumps in the left axilla and right mastoid regions. An excision biopsy of the left axillary lesion and replacement of the ruptured implant was performed. Subsequent histological analysis showed that the axillary lump was a lymph node containing large amounts of silicone. Conclusion The exclusion of malignancy remains the priority when dealing with lumps in the breast or axilla. Silicone lymphadenopathy should however be considered as a differential diagnosis in patients in whom silicone prostheses are present.
Wu, T. Y.; Chen, J. C.; Wang, C. C.
2012-07-01
The objective of this research is to investigate the feasibility of utilizing the instantaneous dimensionless frequency (DLF) normalization and Hilbert-Huang Transform (HHT) to characterize the different gear faults in case of variable rotating speed. The normalized DLF of the vibration signals are calculated based on the rotating speed of shaft and the instantaneous frequencies of Intrinsic Mode Functions (IMFs) which are decomposed by Empirical Mode Decomposition (EMD) process. The faulty gear features on DLF-energy distribution of vibration signal can be extracted without the presence of shaft rotating speed, so that the proposed approach can be applied for characterizing the malfunctions of gearbox system under variable shaft rotating speed. A test rig of gear transmission system is performed to illustrate the gear faults, including worn tooth, broken tooth and gear unbalance. Different methods to determine the instantaneous frequency are employed to verify the consistence of characterization results. The DLF-energy distributions of vibration signals are investigated in different faulty gear conditions. The analysis results demonstrate the capability and effectiveness of the proposed approach for characterizing the gear malfunctions at the DLFs corresponding to the meshing frequency as well as the shaft rotating frequency. The support vector machine (SVM) is then employed to classify the vibration patterns of gear transmission system at different malfunctions. Using the energy distribution at the characteristic DLFs as the features, the different fault types of gear can be identified by SVM with high accuracy.
Mathematical Modelling of Force Convection in a Two-Phase Thermosyphon in Conjugate Formulation
Nurpeiis, Atlant Ediluly; Nee, Aleksandr Eduardovich
2016-01-01
A nonlinear non-stationary problem of the conductive-convective heat transfer is addressed (under forced convection conditions) in the thermosyphon of rectangular cross-section. The thermal energy supply is carried out through the lower horizontal border. The mathematical model is formulated in dimensionless variables of “velocity vorticity vector – current function – temperature”. The current and temperature distribution lines are obtained, illustrating the effect of the Reynolds number on t...
A new approach for dynamic modeling of an electrorheological damper using a lumped parameter method
International Nuclear Information System (INIS)
Nguyen, Quoc-Hung; Choi, Seung-Bok
2009-01-01
This work proposes a new method for dynamic modeling of an electrorheological (ER) damper using a lumped parameter method. After describing the configuration and operating principle of the ER damper, quasi-static modeling of the damper is conducted on the basis of the Bingham model of ER fluid. Subsequently, the lumped parameter models of ER fluid flows in the damper are established and the integrated lumped model of the whole damper system is obtained by taking into account the dynamic motions of the annular duct, upper chamber, lower chamber and connecting pipe. In order to demonstrate the effectiveness of the proposed dynamic model, a comparative work between the simulation and the experiment is undertaken. This is performed under various piston motions with different excitation magnitudes and frequencies. In addition, the effect of ER fluid compressibility and initial pressure in the accumulator on the hysteresis of the ER damper is investigated
Crystallization Formulation Lab
Federal Laboratory Consortium — The Crystallization Formulation Lab fills a critical need in the process development and optimization of current and new explosives and energetic formulations. The...
The lumping of heat transfer parameters in cooled packed beds: effect of the bed entry
Westerink, E.J.; Gerner, J.W.; Gerner, J.W.; Westerterp, K.R.; van der Wal, S.
1993-01-01
The lumping of the heat transfer parameters of the one- and the two-dimensional pseudo-homogeneous model of a cooled fixed bed were compared. It appeared that the lumping of the two-dimensional parameters, being the effective radial conductivity h-eff and the heat transfer coefficient at the wall (alpha)w, into the one-dimensional overall heat transfer coefficient U results in a length dependence of U. It is shown that the ratio (alpha)w/U develops from unity at the bed inlet to a final value...
Praskievicz, S. J.; Luo, C.
2017-12-01
Classification of rivers is useful for a variety of purposes, such as generating and testing hypotheses about watershed controls on hydrology, predicting hydrologic variables for ungaged rivers, and setting goals for river management. In this research, we present a bottom-up (based on machine learning) river classification designed to investigate the underlying physical processes governing rivers' hydrologic regimes. The classification was developed for the entire state of Alabama, based on 248 United States Geological Survey (USGS) stream gages that met criteria for length and completeness of records. Five dimensionless hydrologic signatures were derived for each gage: slope of the flow duration curve (indicator of flow variability), baseflow index (ratio of baseflow to average streamflow), rising limb density (number of rising limbs per unit time), runoff ratio (ratio of long-term average streamflow to long-term average precipitation), and streamflow elasticity (sensitivity of streamflow to precipitation). We used a Bayesian clustering algorithm to classify the gages, based on the five hydrologic signatures, into distinct hydrologic regimes. We then used classification and regression trees (CART) to predict each gaged river's membership in different hydrologic regimes based on climatic and watershed variables. Using existing geospatial data, we applied the CART analysis to classify ungaged streams in Alabama, with the National Hydrography Dataset Plus (NHDPlus) catchment (average area 3 km2) as the unit of classification. The results of the classification can be used for meeting management and conservation objectives in Alabama, such as developing statewide standards for environmental instream flows. Such hydrologic classification approaches are promising for contributing to process-based understanding of river systems.
Radiative-conductive inverse problem for lumped parameter systems
International Nuclear Information System (INIS)
Alifanov, O M; Nenarokomov, A V; Gonzalez, V M
2008-01-01
The purpose of this paper is to introduce a iterative regularization method in the research of radiative and thermal properties of materials with applications in the design of Thermal Control Systems (TCS) of spacecrafts. In this paper the radiative and thermal properties (emissivity and thermal conductance) of a multilayered thermal-insulating blanket (MLI), which is a screen-vacuum thermal insulation as a part of the (TCS) for perspective spacecrafts, are estimated. Properties of the materials under study are determined in the result of temperature and heat flux measurement data processing based on the solution of the Inverse Heat Transfer Problem (IHTP) technique. Given are physical and mathematical models of heat transfer processes in a specimen of the multilayered thermal-insulating blanket located in the experimental facility. A mathematical formulation of the inverse heat conduction problem is presented too. The practical testing were performed for specimen of the real MLI.
School-based management in the Netherlands: the educational consequences of lump-sum funding
Karsten, S.; Meijer, J.
1999-01-01
Important changes are taking place in the ways schools are funded in a large number of countries. In by far the majority of cases, these changes involve more freedom at the school level to decide how money should be spent. The Netherlands has had lump-sum funding in vocational secondary education
Breast Lumps: A 21‑Year Single‑Center Clinical and Histological ...
African Journals Online (AJOL)
Results: Only 38% of the patients came within 3 months of finding lumps in their breast. Onehundred and thirty‑seven patients (83%) had benign disease, i.e., fibroadenoma, mammary dysplasia, cysts, adenomas, tuberculosis, phyllodes tumor, mastitis, and lipoma. Only 16.9% i.e., 28 patients had breast cancer, out of which ...
Breast Lumps: A 21‑Year Single‑Center Clinical and Histological ...
African Journals Online (AJOL)
Patients complaining of breast disorders form a large proportion of outpatients in general surgical clinics. The presence of a lump in the breast is a great cause of anxiety and apprehension in females, young and old. Public awareness of breast cancer has contributed largely to this, and the consequence is a steady flow.
Emergence and space–time structure of lump solution to the (2 1 ...
Indian Academy of Sciences (India)
Wei Tan
2017-10-31
Oct 31, 2017 ... Abstract. A periodic breather-wave solution is obtained using homoclinic test approach and Hirota's bilinear method with a small perturbation parameter u0 for the (2+1)-dimensional generalized Kadomtsev–Petviashvili equation. Based on the periodic breather-wave, a lump solution is emerged by limit ...
Emergence and space–time structure of lump solution to the (2 1 ...
Indian Academy of Sciences (India)
Wei Tan
2017-10-31
Oct 31, 2017 ... breather-wave solution (also known as rogue wave solu- tion) of eq. (2) by using the homoclinic (heteroclinic) breather limit method (HBLM). Ma [4] studied a class of lump solution of eq. (2) by selecting a special quadratic function with Hirota's bilinear form, and they also anal- ysed the rational localization ...
DRAINMOD-GIS: a lumped parameter watershed scale drainage and water quality model
G.P. Fernandez; G.M. Chescheir; R.W. Skaggs; D.M. Amatya
2006-01-01
A watershed scale lumped parameter hydrology and water quality model that includes an uncertainty analysis component was developed and tested on a lower coastal plain watershed in North Carolina. Uncertainty analysis was used to determine the impacts of uncertainty in field and network parameters of the model on the predicted outflows and nitrate-nitrogen loads at the...
Seventeen-lump model for the simulation of an industrial fluid ...
Indian Academy of Sciences (India)
BINAY SINGH
2017-10-06
Oct 6, 2017 ... Abstract. A 17-lump kinetic model has been developed for the riser–reactor cum regenerator of a fluid catalytic cracking unit (FCCU). This accounts for cracking, hydrogen transfer, aromatization, isomerization, alkylation and dimerization, as well as catalyst deactivation due to the coke deposition in its pores.
Seventeen-lump model for the simulation of an industrial fluid ...
Indian Academy of Sciences (India)
A 17-lump kinetic model has been developed for the riser–reactor cum regenerator of a fluid catalytic cracking unit (FCCU). This accounts for cracking, hydrogen transfer, aromatization, isomerization, alkylation and dimerization, as well as catalyst deactivation due to the coke deposition in its pores. A model forthe industrial ...
Managing lump sum contracts : what will it take for contractors to jump on board?
Energy Technology Data Exchange (ETDEWEB)
Trowsdale, R. [Epcor Power Development Corp., Toronto, ON (Canada)
2005-07-01
Lump sum contracting considerations were examined from the perspective of EPCOR Power Development Corporation. Details of EPCOR's facilities and planned projects were provided, as well as plant performance and reliability expectations. Various lump sum projects contracted by EPCOR were reviewed, as well as issues concerning performance-based and detail-oriented methods of project management. It was suggested that contractors must be aware of their own financial capacity and be provided with a clear scope definition. An understanding of the financial capacity, safety and environmental performance of contractors was recommended, as well as the development of capital cost and commissioning schedule certainties. An understanding of the risks and technical requirements on the behalf of contractors was advised. It was noted that contracts are generally comprised of a number of fixed price components. and that maximizing lump sum elements provides an incentive for contractors to find innovative ways of minimizing their costs while meeting project objectives. It was suggested that the party who has the greatest ability to control a risk should be responsible for that risk. It was noted that owners frequently lack the ability to influence contractor performance. It was concluded that lump sum contractors require the ability to deliver and an equitable contract. Contractors must have an ability to understand risks, as well as have the prospects for additional profitable work. tabs., figs.
Van Dyke, Michael B.
2013-01-01
Present preliminary work using lumped parameter models to approximate dynamic response of electronic units to random vibration; Derive a general N-DOF model for application to electronic units; Illustrate parametric influence of model parameters; Implication of coupled dynamics for unit/board design; Demonstrate use of model to infer printed wiring board (PWB) dynamics from external chassis test measurement.
Simulation of hydrogen deflagration experiment – Benchmark exercise with lumped-parameter codes
International Nuclear Information System (INIS)
Kljenak, Ivo; Kuznetsov, Mikhail; Kostka, Pal; Kubišova, Lubica; Maltsev, Mikhail; Manzini, Giovanni; Povilaitis, Mantas
2015-01-01
Highlights: • Blind and open simulations of hydrogen combustion experiment in large-scale containment-like facility with different lumped-parameter codes. • Simulation of axial as well as radial flame propagation. • Confirmation of adequacy of lumped-parameter codes for safety analyses of actual nuclear power plants. - Abstract: An experiment on hydrogen deflagration (Upward Flame Propagation Experiment – UFPE) was proposed by the Jozef Stefan Institute (Slovenia) and performed in the HYKA A2 facility at the Karlsruhe Institute of Technology (Germany). The experimental results were used to organize a benchmark exercise for lumped-parameter codes. Six organizations (JSI, AEP, LEI, NUBIKI, RSE and UJD SR) participated in the benchmark exercise, using altogether four different computer codes: ANGAR, ASTEC, COCOSYS and ECART. Both blind and open simulations were performed. In general, all the codes provided satisfactory results of the pressure increase, whereas the results of the temperature show a wider dispersal. Concerning the flame axial and radial velocities, the results may be considered satisfactory, given the inherent simplification of the lumped-parameter description compared to the local instantaneous description
Chin-Joe-Kong, M.J.S.; Mulder, W.A.; van Veldhuizen, M.
1999-01-01
The higher-order finite-element scheme with mass lumping for triangles and tetrahedra is an efficient method for solving the wave equation. A number of lower-order elements have already been found. Here the search for elements of higher order is continued. Elements are constructed in a systematic
Hu, Cong-Cong; Tian, Bo; Wu, Xiao-Yu; Yuan, Yu-Qiang; Du, Zhong
2018-02-01
Under investigation is a (3 + 1) -dimensional B-type Kadomtsev-Petviashvili equation, which describes the weakly dispersive waves in a fluid. Via the Hirota method and symbolic computation, we obtain the mixed lump-kink and mixed rogue wave-kink solutions. Through the mixed lump-kink solutions, we observe three different phenomena between a lump and one kink. For the fusion phenomenon, a lump and a kink are merged with the lump's energy transferring into the kink gradually, until the lump merges into the kink completely. Fission phenomenon displays that a lump separates from a kink. The last phenomenon shows that a lump travels together with a kink with their amplitudes unchanged. In addition, we graphically study the interaction between a rogue wave and a pair of the kinks. It can be observed that the rogue wave arises from one kink and disappears into the other kink. At certain time, the amplitude of the rogue wave reaches the maximum.
International Nuclear Information System (INIS)
Ozdemir, Ozkan Emre; George, Thomas L.
2015-01-01
As a part of the GOTHIC (GOTHIC incorporates technology developed for the electric power industry under the sponsorship of EPRI.) Fukushima Technical Evaluation project (EPRI, 2014a, b, 2015), GOTHIC (EPRI, 2014c) has been benchmarked against test data for pool stratification (EPRI, 2014a, b, Ozdemir and George, 2013). These tests confirmed GOTHIC’s ability to simulate pool mixing and stratification under a variety of anticipated suppression pool operating conditions. The multidimensional modeling requires long simulation times for events that may occur over a period of hours or days. For these scenarios a lumped model of the pressure suppression chamber is desirable to maintain reasonable simulation times. However, a lumped model for the pool is not able to predict the effects of pool stratification that can influence the overall containment response. The main objective of this work is on the development of a correlation that can be used to estimate pool mixing and stratification effects in a lumped modeling approach. A simplified lumped GOTHIC model that includes a two zone model for the suppression pool with controlled circulation between the upper and lower zones was constructed. A pump and associated flow connections are included to provide mixing between the upper and lower pool volumes. Using numerically generated data from a multidimensional GOTHIC model for the suppression pool, a correlation was developed for the mixing rate between the upper and lower pool volumes in a two-zone, lumped model. The mixing rate depends on the pool subcooling, the steam injection rate and the injection depth
Assessment of health risks due to arsenic from iron ore lumps in a beach setting.
Swartjes, Frank A; Janssen, Paul J C M
2016-09-01
In 2011, an artificial hook-shaped peninsula of 128ha beach area was created along the Dutch coast, containing thousands of iron ore lumps, which include arsenic from natural origin. Elemental arsenic and inorganic arsenic induce a range of toxicological effects and has been classified as proven human carcinogens. The combination of easy access to the beach and the presence of arsenic raised concern about possible human health effects by the local authorities. The objective of this study is therefore to investigate human health risks from the presence of arsenic-containing iron ore lumps in a beach setting. The exposure scenarios underlying the human health-based risk limits for contaminated land in The Netherlands, based on soil material ingestion and a residential setting, are not appropriate. Two specific exposure scenarios related to the playing with iron ore lumps on the beach ('sandcastle building') are developed on the basis of expert judgement, relating to children in the age of 2 to 12years, i.e., a worst case exposure scenario and a precautionary scenario. Subsequently, exposure is calculated by the quantification of the following factors: hand loading, soil-mouth transfer effectivity, hand-mouth contact frequency, contact surface, body weight and the relative oral bioavailability factor. By lack of consensus on a universal reference dose for arsenic for use in the stage of risk characterization, three different types of assessments have been evaluated: on the basis of the current Provisional Tolerable Daily Intake (PTWI), on the basis of the Benchmark Dose Lower limit (BMDL), and by a comparison of exposure from the iron ore lumps with background exposure. It is concluded, certainly from the perspective of the conservative exposure assessment, that unacceptable human health risks due to exposure to arsenic from the iron ore lumps are unlikely and there is no need for risk management actions. Copyright © 2016 Elsevier B.V. All rights reserved.
Brown, Ann L; Phillips, Jordana; Slanetz, Priscilla J; Fein-Zachary, Valerie; Venkataraman, Shambhavi; Dialani, Vandana; Mehta, Tejas S
2017-10-01
The purpose of this study was to determine whether mammography adds clinical value in the diagnostic imaging workup of women 30 years old and older who present with palpable breast lumps. We retrospectively identified the records of all women 30 years old and older who underwent imaging evaluation with mammography and ultrasound for a palpable lump between January 1, 2009, and December 31, 2010. Imaging reports were reviewed for findings related to the lump and for incidental nonpalpable findings. Benign versus malignant outcomes were determined by pathologic analysis or 24-month imaging or clinical follow-up. The contribution of mammography to final diagnosis was assessed on the basis of objective criteria to determine the clinical impact of mammographic findings. The study cohort included 861 patients presenting with 935 palpable lumps. Imaging correlates were reported for 568 of 935 (60.7%) lumps, and imaging findings were negative in 367 of 935 (39.3%). Of the 935 palpable lumps, 858 (91.8%) were benign and 77 (8.2%) were malignant. Mammography added clinical value in the evaluation of 27 of 77 (35.0%) malignant lumps by better delineating extent of disease and in the evaluation of 26 of 858 benign lumps (3.0%) by confirming benignity. Fifty-two of 861 (6.0%) patients had incidental findings that led to a recommendation for biopsy. Twenty-nine of the 52 findings were originally seen with mammography and 23 with ultrasound. Mammography also depicted seven incidental malignancies in nonpalpable areas, and ultrasound depicted one incidental malignancy. Adjunct mammography is warranted for evaluation of palpable breast lumps in women 30 years old and older because of the value added to clinical management. In all age cohorts, mammography contributed to delineation of disease extent, detection of incidental malignancies, and confirmation of benign diagnoses.
IT Supporting Strategy Formulation
Achterbergh, J.M.I.M.; Khosrow-Pour, M.
2005-01-01
This overview approaches information and communication technology (ICT) for competitive intelligence from the perspective of strategy formulation. It provides an ICT architecture for supporting the knowledge processes producing relevant knowledge for strategy formulation. To determine what this
DEFF Research Database (Denmark)
Bahman, Amir Sajjad; Ma, Ke; Blaabjerg, Frede
2018-01-01
Detailed thermal dynamics of high power IGBT modules are important information for the reliability analysis and thermal design of power electronic systems. However, the existing thermal models have their limits to correctly predict these complicated thermal behavior in the IGBTs: The typically used...... thermal model based on one-dimensional RC lumps have limits to provide temperature distributions inside the device, moreover some variable factors in the real-field applications like the cooling and heating conditions of the converter cannot be adapted. On the other hand, the more advanced three......-dimensional thermal models based on Finite Element Method (FEM) need massive computations, which make the long-term thermal dynamics difficult to calculate. In this paper, a new lumped three-dimensional thermal model is proposed, which can be easily characterized from FEM simulations and can acquire the critical...
A Novel T-Fed 4-Element Quasi-Lumped Resonator Antenna Array
Directory of Open Access Journals (Sweden)
S.S. Olokede
2014-06-01
Full Text Available In this paper, electrically small corporately T-fed quasi-lumped element resonator antenna array is investigated. The radiating element, a quasi-lumped element resonator is excited by a novel semi hybrid ring-like T-shaped corporate feed network. The characteristics losses due to Ohmic and discontinuities along the feed line which invariably constitutes complex feed structures are mitigated at the instance of the proposed antenna. Technique to implement the compact array with the intent to enhance the gain is presented. The operation dynamics of the feed along with its theoretical explanation is also reported. Findings indicates that the measured gain is 10.97 dBi for antenna of an estate area of about 0.677λ_0 × 1.257λ_0 sq. mm. Valuable insight to the optimum design in terms of compactness, good gain, and ease of fabrication is documented.
Breast lumps: A 21-year single-center clinical and histological analysis
Directory of Open Access Journals (Sweden)
Gabriel E Njeze
2014-01-01
Full Text Available Objective: To review the presentation and histological diagnosis of breast lumps of patients seen in Trans Ekulu Hospital Enugu Southeastern Nigeria from 1993 to 2013 in a period of 21 years. Materials and Methods: This is a retrospective study covering a period of 21 years. Case notes of patients containing clinical information and their histology reports were studied. Results: Only 38% of the patients came within 3 months of finding lumps in their breast. One hundred and thirty-seven patients (83% had benign disease, i.e., fibroadenoma, mammary dysplasia, cysts, adenomas, tuberculosis, phyllodes tumor, mastitis, and lipoma. Only 16.9% i.e., 28 patients had breast cancer, out of which two females were in their 20s, and three were males. Conclusions: Benign breast diseases, i.e., fibroadenoma, fibroadenosis, cysts, adenomas, tuberculosis, phyllodes, mastitis, and lipoma are the commoner breast diseases in our locality.
Lumped-parameter modeling of one-dimensional two-phase flow
International Nuclear Information System (INIS)
Wulff, W.
1978-01-01
An integral or lumped-parameter modeling technique is presented for the analysis of nonequilibrium, nonhomogeneous, one-dimensional two-phase flow. The method is designed to increase computing efficiency over standard finite difference techniques and to describe accurately the motion of flow regime interfaces. Computing efficiency is achieved by converting the partial differential equations of the conservation laws into ordinary differential equations and by introducing profile estimates. Flow regime interfaces are tracked with the aid of kinematic jump conditions. The governing equations are derived, and the method is elucidated on three applications. One application involves a closed-loop transient, the second one involves the dynamics of a liquid level, while the third application deals with the level swelling above a nonhomogeneous two-phase mixture. Comparisons are presented between lumped parameter modeling solutions, solutions from finite difference techniques and analytical solutions. The comparisons show good agreement. The important role of profile functions is discussed
Improvement of Stopband Performance in Parallel-Coupled Bandpass Filters Using Quasi-Lumped Elements
DEFF Research Database (Denmark)
Zhurbenko, Vitaliy; Krozer, Viktor; Meincke, Peter
2008-01-01
bandpass filter has a compact footprint, and exhibits good stopband rejection with no repeated passband at twice the center frequency in comparison with the traditional coupled-line filter. By introducing the quasi-lumped element resonator, two transmission zeros at upper and lower stopbands are created......, with adjustable locations of transmission zeros for desired performance. The device is fabricated in standard thick-film manufacturing technology. Based on parallel-coupled line theory, the impedance inverter model for this device is developed. The passband filter centered at 5.5 GHz with a 3 dB relative......This paper is aimed at improving the rejection level as well as overcoming the bandwidth limitations for classical coupled-line filters. A planar microwave coupled-line filter employing a quasi-lumped element resonator considerably improving the stopband characteristics is presented. The proposed...
Yoshiaki, A; Zhang, Y C
2002-01-01
Embedded nano-Pd particles of 5 nm in size instantly abundant D-atoms more than 250% in the atomic ratio against Pd-atoms at room temperature when they are kept in D sub 2 gas pressurized to less than 10 atm. In such ultrahigh densities, 2-4 D-atoms can be coagulated inside each octahedral space of Pd lattice (pycnodeuterium-lump). When a stimulation energy such as latticequake causing by ultrasonic wave was supplied to those highly deuterated Pd particles, intense deuterium nuclear fusion (''solid fusion'') was generated there and both excess heat and sup 4 He gas were abundantly produced. Naturally, these facts can not be realized at all in bulk Pd. The results show that the nuclear fusion occurs without any hazardous rays in pycnodeuterium-lumps coagulated locally inside the each cell of the host metal lattice. These unit cells correspond to minimum unit of the solid fusion reactor as a ''Lattice Reactor''. (author)
A modal-energy based equivalent lumped model for open cracks
Jalali, Hassan; Noohi, Fahimeh
2018-01-01
Two modeling methods are proposed for open notch-like cracks in beam structures. In exact modeling method, the cracked beam is divided into 3 parts - two beams and one crack parts - and its natural frequency analysis is done by assuming that shear beam theory governs the dynamic behavior of the structure. In equivalent modeling method, an equivalent lumped model composed of a set of lateral, torsional and lateral-torsional springs is considered for crack part. The stiffness coefficients of the equivalent lumped model are obtained by comparing the two modeling methods in a modal-energy based approach. The accuracy of the proposed modeling methods are verified by numerous numerical and experimental case studies.
International Nuclear Information System (INIS)
Salama, D.H.
2008-01-01
The environmental risk factors related to the breast tumors (lumps) are essential in order to build strategies to decrease cancer incidence and mortality among different socioeconomic and cultural backgrounds. A case control study of 70 cases and 52 controls were classified into high, middle and low socioeconomic classes. The results revealed significant increased risk of breast tumors among working females, having positive family history, married with lower mean parity, with higher consumption of fatty meals, lesser meat intake. Non significant risk factors were the social class, exposure to ionizing radiation, non lactating. wearing tight bra, consumption of vegetables and fruits, oral contraceptive pill users and exposure to outdoor air pollution or indoor pollution as floors and wall paintings. In conclusion, this study highlights the positive life style for egyptian women so they can prevent some of the environmental risks of breast tumors. Increasing the awareness of breast diseases and regular examination remains the corner stone for early detection management of breast lumps.
A Size Reduction Technique for Mobile Phone PIFA Antennas Using Lumped Inductors
DEFF Research Database (Denmark)
Thaysen, Jesper; Jakobsen, Kaj Bjarne
2005-01-01
A size reduction technique for the planar inverted-F antenna (PIFA) is presented. An 18 nH lumped inductor is used in addition to a small 0.3 cm3 PIFA. The PIFA is located on dielectric foam, 5 mm above a 40 mm × 100 mm ground plane. It is possible to reduce the center frequency (|S11|min) by 33 ...
Regular versus lump-sum payments in union contracts and household consumption
Adamopoulou, Effrosyni; Zizza, Roberta
2017-01-01
We use information on monthly wage increases set by collective agreements in Italy and exploit their variation across sectors and over time in order to examine how household consumption responds to different types of positive income shocks (regular tranches versus lump-sum payments). Focusing on single-earner households, we find evidence of consumption smoothing in accordance with the Permanent-Income Hypothesis, since total and food consumption do not exhibit excess sensitivity to anticipate...
Method for Lumped Parameter simulation of Digital Displacement pumps/motors based on CFD
DEFF Research Database (Denmark)
Rømer, Daniel; Johansen, Per; Pedersen, Henrik C.
2013-01-01
Digital displacement fluid power pumps/motors offers improved efficiency and performance compared to traditional variable displacement pump/motors. These improvements are made possible by using efficient electronically controlled seat valves and careful design of the flow geometry. To optimize th...... parameters based on steady CFD results, in order to take detailed geometry information into account. The response of the lumped parameter model is compared to a computational expensive transient CFD model for an example geometry....
Discrete Spectrum of 2 + 1-Dimensional Nonlinear Schrödinger Equation and Dynamics of Lumps
Directory of Open Access Journals (Sweden)
Javier Villarroel
2016-01-01
Full Text Available We consider a natural integrable generalization of nonlinear Schrödinger equation to 2+1 dimensions. By studying the associated spectral operator we discover a rich discrete spectrum associated with regular rationally decaying solutions, the lumps, which display interesting nontrivial dynamics and scattering. Particular interest is placed in the dynamical evolution of the associated pulses. For all cases under study we find that the relevant dynamics corresponds to a central configuration of a certain N-body problem.
Directory of Open Access Journals (Sweden)
S P Susheela
2015-05-01
Full Text Available Hepatocellular carcinoma (HCC is one of the most common malignancies and is known to most often present with symptomatology pertaining to local hepatic disease. Although HCC is known to metastasize to lungs, abdominal lymph nodes, adrenal glands and the vertebral column, it is rather rare to come across patients with skull metastasis. The manifestation of a solitary frontal bone metastasis leading to a painless lump over the forehead as the initial presenting feature of HCC is highly unusual. This case report pertains to a 40-year-old male patient who had initially observed a painless lump over his forehead that was gradually increasing in size over a span of 3 months. He sought medical attention when, after several months, the "painless lump" suddenly became painful. Investigations revealed the involvement of both the outer and the inner table of the frontal bone, and a biopsy revealed the histopathology to be that of HCC. On further investigation, he was found to have systemic disseminated disease involving both the left and right lungs and vertebrae and treatment was initiated with sorafenib. Despite an initial partial response, the patient subsequently succumbed to hepatic failure. This case report illustrates the fact that HCC can silently progress, and even lead to dissemination and distant metastases before becoming clinically evident.
Liu, Jian; Gao, Yun-Hua; Li, Ding-Dong; Gao, Yan-Chun; Hou, Ling-Mi; Xie, Ting
2014-01-01
To compare the value of contrast-enhanced ultrasound (CEUS) qualitative and quantitative analysis in the identification of breast tumor lumps. Qualitative and quantitative indicators of CEUS for 73 cases of breast tumor lumps were retrospectively analyzed by univariate and multivariate approaches. Logistic regression was applied and ROC curves were drawn for evaluation and comparison. The CEUS qualitative indicator-generated regression equation contained three indicators, namely enhanced homogeneity, diameter line expansion and peak intensity grading, which demonstrated prediction accuracy for benign and malignant breast tumor lumps of 91.8%; the quantitative indicator-generated regression equation only contained one indicator, namely the relative peak intensity, and its prediction accuracy was 61.5%. The corresponding areas under the ROC curve for qualitative and quantitative analyses were 91.3% and 75.7%, respectively, which exhibited a statistically significant difference by the Z test (Pqualitative analysis to identify breast tumor lumps is better than with quantitative analysis.
Definition of datum of materials lump size on conveyors by means of reflected gamma-radiation method
International Nuclear Information System (INIS)
Gal'yanov, A.V.; Antonov, V.A.; Laptev, Yu.V.
2001-01-01
A method of technological control of large-size lumps in conveyor-transported crushed material based on intensity measurement of X-ray and gamma radiation reflected from the material surface was suggested. The method was substantiated theoretically and as a result it was shown that dispersion of radiation intensity, multiply measured for short periods of time, can be analytic parameter of large-size lumps yield. Principled methodical and design recommendations on the method practical applications are given [ru
Karimi, Leila; Ghassemi, Abbas
2016-07-01
Among the different technologies developed for desalination, the electrodialysis/electrodialysis reversal (ED/EDR) process is one of the most promising for treating brackish water with low salinity when there is high risk of scaling. Multiple researchers have investigated ED/EDR to optimize the process, determine the effects of operating parameters, and develop theoretical/empirical models. Previously published empirical/theoretical models have evaluated the effect of the hydraulic conditions of the ED/EDR on the limiting current density using dimensionless numbers. The reason for previous studies' emphasis on limiting current density is twofold: 1) to maximize ion removal, most ED/EDR systems are operated close to limiting current conditions if there is not a scaling potential in the concentrate chamber due to a high concentration of less-soluble salts; and 2) for modeling the ED/EDR system with dimensionless numbers, it is more accurate and convenient to use limiting current density, where the boundary layer's characteristics are known at constant electrical conditions. To improve knowledge of ED/EDR systems, ED/EDR models should be also developed for the Ohmic region, where operation reduces energy consumption, facilitates targeted ion removal, and prolongs membrane life compared to limiting current conditions. In this paper, theoretical/empirical models were developed for ED/EDR performance in a wide range of operating conditions. The presented ion removal and selectivity models were developed for the removal of monovalent ions and divalent ions utilizing the dominant dimensionless numbers obtained from laboratory scale electrodialysis experiments. At any system scale, these models can predict ED/EDR performance in terms of monovalent and divalent ion removal. Copyright © 2016 Elsevier Ltd. All rights reserved.
Kasperek, Regina
2011-01-01
The release of diclofenac sodium and papaverine hydrochloride from tablets and pellets using the flow-through cell apparatus was studied. The influence of excipients and of a size of the solid dosage forms on the amount of the released substances at the intervals of time using the different rates of flow of the dissolution medium was investigated. Physical parameters corresponding to the dissolution process as the mass transfer coefficient, the thickness of the boundary diffusion layer and the concentration of the saturated solution at this layer were calculated. The results of release were described by dimensionless equations.
Aquaculture project formulation
National Research Council Canada - National Science Library
Insull, David; Nash, Colin E
1990-01-01
.... The first part of the document contains a broad introduction to project formulation, describing the integration of aquaculture projects within development plans, the organization and management...
Explosive Formulation Pilot Plant
Federal Laboratory Consortium — The Pilot Plant for Explosive Formulation supports the development of new explosives that are comprised of several components. This system is particularly beneficial...
Agishev, Ravil; Comerón, Adolfo; Rodriguez, Alejandro; Sicard, Michaël
2014-05-20
In this paper, we show a renewed approach to the generalized methodology for atmospheric lidar assessment, which uses the dimensionless parameterization as a core component. It is based on a series of our previous works where the problem of universal parameterization over many lidar technologies were described and analyzed from different points of view. The modernized dimensionless parameterization concept applied to relatively new silicon photomultiplier detectors (SiPMs) and traditional photomultiplier (PMT) detectors for remote-sensing instruments allowed predicting the lidar receiver performance with sky background available. The renewed approach can be widely used to evaluate a broad range of lidar system capabilities for a variety of lidar remote-sensing applications as well as to serve as a basis for selection of appropriate lidar system parameters for a specific application. Such a modernized methodology provides a generalized, uniform, and objective approach for evaluation of a broad range of lidar types and systems (aerosol, Raman, DIAL) operating on different targets (backscatter or topographic) and under intense sky background conditions. It can be used within the lidar community to compare different lidar instruments.
Suitability of different formulated carriers for sustaining microbial shelf life
International Nuclear Information System (INIS)
Tabassam, T.; Ali, A.
2014-01-01
Non-availability of a suitable carrier for bioinnoculant is a serious constraint for dissemination of biofertilizer technology in Pakistan. Present study was designed to formulate a suitable carrier from locally available cheap material and evaluate for shelf life by using locally isolated plant growth promoting rhizobacteria (PGPR) strains from maize rhizosphere. Different combinations of material were prepared using clay soil (35-50%), fly-ash (30-45%), press mud (5-15%) and lignite (5-15%). Clay soil (53% clay) was used for adhesion purpose but considering free of lump formation an important property of a good carrier, mixing 40% of soil with other material was found suitable. Using 40% of soil, six different treatments were formulated and physico-chemical characteristics were determined. Four combinations in the range of 40% clay, 30-40% fly-ash, 10-15% press mud and 10-15% lignitic coal were selected which had good adhesion capacity, moisture holding capacity, nutrient contents and investigated for microbial shelf life. Significant difference regarding microbial survival was observed between different formulations as well as between different incubation intervals. Among different carrier tested the FC-4 supported the maximum population of 33.5x10- 10.8x10 cfu g for MR-8 and 32.6x10 - 7.2x10 cfu g for MR-5. Results showed that the required population of PGPR was sustained in all the formulation tested up to six months of storage period. (author)
Duval, Jérôme F L
2017-05-17
Soft nanoparticulate complexants are defined by a spatial confinement of reactive sites and electric charges inside their 3D body. In turn, their reactivity with metal ions differs significantly from that of simple molecular ligands. A revisited form of the Eigen mechanism recently elucidated the processes leading to metal/soft particle pair formation. Depending on e.g. particle size and metal ion nature, chemodynamics of nanoparticulate metal complexes is controlled by metal conductive diffusion to/from the particles, by intraparticulate complex formation/dissociation kinetics, or by both. In this study, a formalism is elaborated to achieve a comprehensive and systematic identification of the rate-limiting step governing the overall formation and dissociation of nanoparticulate metal complexes. The theory covers the different types of spherical particulate complexants, i.e. 3D soft/permeable and core-shell particles, and hard particles with reactive sites at the surface. The nature of the rate-limiting step is formulated by a dynamical criterion involving a power law function of the ratio between particle radius and an intraparticulate reaction layer thickness defined by the key electrostatic, diffusional and kinetic components of metal complex formation/dissociation. The analysis clarifies the intertwined contributions of particle properties (size, soft or hard type, charge, density or number of reactive sites) and aqueous metal ion dehydration kinetics in defining the chemodynamic behavior of nanoparticulate metal complexes. For that purpose, fully parameterized chemodynamic portraits involving the defining features of particulate ligand and metal ion as well as the physicochemical conditions in the local intraparticulate environment, are constructed and thoroughly discussed under conditions of practical interest.
Study of Pellets and Lumps as Raw Materials in Silicon Production from Quartz and Silicon Carbide
Dal Martello, E.; Tranell, G.; Gaal, S.; Raaness, O. S.; Tang, K.; Arnberg, L.
2011-10-01
The use of high-purity carbon and quartz raw materials reduces the need for comprehensive refining steps after the silicon has been produced carbothermically in the electric reduction furnace. The current work aims at comparing the reaction mechanisms and kinetics occurring in the inner part of the reduction furnace when pellets or lumpy charge is used, as well as the effect of the raw material mix. Laboratory-scale carbothermic reduction experiments have been carried out in an induction furnace. High-purity silicon carbide and two different high-purity hydrothermal quartzes were charged as raw materials at different molar ratios. The charge was in the form of lumps (size, 2-5 mm) or as powder (size, 10-20 μm), mixed and agglomerated as pellets (size, 1-3 mm) and reacted at 2273 K (2000 °C). The thermal properties of the quartzes were measured also by heating a small piece of quartz in CO atmosphere. The investigated quartzes have different reactivity in reducing atmosphere. The carbothermal reduction experiments show differences in the reacted charge between pellets and lumps as charge material. Solid-gas reactions take place from the inside of the pellets porosity, whereas reactions in lumps occur topochemically. Silicon in pellets is produced mainly in the rim zone. Larger volumes of silicon have been found when using lumpy charge. More SiO is produced when using pellets than for lumpy SiO2 for the same molar ratio and heating conditions. The two SiC polytypes used in the carbothermal reduction experiments as carbon reductants presented different reactivity.
Some features of vibrations in homogeneous 1D resistant elastic lumped line
Karavashkin, S B
2002-01-01
In this paper we will consider the effect of resistance on vibration processes in a semi-infinite elastic lumped and distributed lines. We will see that for the given type of line, the progressive pattern of vibrations remains also at the overcritical frequencies, and the phase delay is always less than the value, corresponding to the first Brillouin zone. Comparing the obtained results with experimental data of the phase velocity of ultrasonic wave in the carbonic acid gas, we will see that taking the resistance into consideration, we can essentially refine the conventional models and promote their better correspondence to the experimental data.
Unbiased Charged Circular CMUT Microphone: Lumped-Element Modeling and Performance.
Koymen, Hayrettin; Atalar, Abdullah; Guler, Saadettin; Koymen, Itir; Tasdelen, A Sinan; Unlugedik, Asli
2018-01-01
An energy-consistent lumped-element equivalent circuit model for charged circular capacitive micromachined ultrasonic transducer (CMUT) cell is derived and presented. It is analytically shown and experimentally verified that a series dc voltage source at the electrical terminals is sufficient to model the charging in CMUT. A model-based method for determining this potential from impedance measurements at low bias voltages is presented. The model is validated experimentally using an airborne CMUT, which resonates at 103 kHz. Impedance measurements, reception measurements at resonance and off-resonance, and the transient response of the CMUT are compared with the model predictions.
Cultural factors associated with the management of breast lumps amongst Xhosa women
Directory of Open Access Journals (Sweden)
Nosipho Mdondolo
2003-11-01
Full Text Available A qualitative research design and an ethno-nursing research method were used to identify cultural factors influencing Xhosa women’s health seeking behaviours associated with breast lumps. Opsomming ’n Kwalitatiewe navorsingsontwerp en ’n etnoverpleegkundige navorsingsmetode is gebruik. Die doel was om te bepaal watter kulturele faktore Xhosa vroue se strewe na welstand, wat in verband staan met ’n borsvergroeisel, beïnvloed. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.
Porter, Christina L.; Miley, Galen P.; Griffiths, David J.; Sánchez, Erik
2014-12-01
A phenomenon resembling natural ball lightning can be produced via electrical arcing through silicon. We use lump silicon instead of silicon wafers to achieve higher production rates and larger, longer-lived luminous balls than previously reported. The luminous balls consist of a silicon core surrounded by a porous network of loosely bound silicon dioxide nanoparticles. We find that the balls carry a small net charge on the order of 10-12 C and propose that the nanoparticles are electrostatically bound to the core due to this charge.
New Procedure to Develop Lumped Kinetic Models for Heavy Fuel Oil Combustion
Han, Yunqing
2016-09-20
A new procedure to develop accurate lumped kinetic models for complex fuels is proposed, and applied to the experimental data of the heavy fuel oil measured by thermogravimetry. The new procedure is based on the pseudocomponents representing different reaction stages, which are determined by a systematic optimization process to ensure that the separation of different reaction stages with highest accuracy. The procedure is implemented and the model prediction was compared against that from a conventional method, yielding a significantly improved agreement with the experimental data. © 2016 American Chemical Society.
Audits of radiopharmaceutical formulations
International Nuclear Information System (INIS)
Castronovo, F.P. Jr.
1992-01-01
A procedure for auditing radiopharmaceutical formulations is described. To meet FDA guidelines regarding the quality of radiopharmaceuticals, institutional radioactive drug research committees perform audits when such drugs are formulated away from an institutional pharmacy. All principal investigators who formulate drugs outside institutional pharmacies must pass these audits before they can obtain a radiopharmaceutical investigation permit. The audit team meets with the individual who performs the formulation at the site of drug preparation to verify that drug formulations meet identity, strength, quality, and purity standards; are uniform and reproducible; and are sterile and pyrogen free. This team must contain an expert knowledgeable in the preparation of radioactive drugs; a radiopharmacist is the most qualified person for this role. Problems that have been identified by audits include lack of sterility and apyrogenicity testing, formulations that are open to the laboratory environment, failure to use pharmaceutical-grade chemicals, inadequate quality control methods or records, inadequate training of the person preparing the drug, and improper unit dose preparation. Investigational radiopharmaceutical formulations, including nonradiolabeled drugs, must be audited before they are administered to humans. A properly trained pharmacist should be a member of the audit team
Mathematical Modelling of Force Convection in a Two–Phase Thermosyphon in Conjugate Formulation
Directory of Open Access Journals (Sweden)
Nurpeiis Atlant
2016-01-01
Full Text Available A nonlinear non-stationary problem of the conductive-convective heat transfer is addressed (under forced convection conditions in the thermosyphon of rectangular cross-section. The thermal energy supply is carried out through the lower horizontal border. The mathematical model is formulated in dimensionless variables of “velocity vorticity vector – current function – temperature”. The current and temperature distribution lines are obtained, illustrating the effect of the Reynolds number on the thermodynamic structures formation in the analyzed object.
Feasibility study of producing lump fuel using oil-bituminous sands
Energy Technology Data Exchange (ETDEWEB)
Moldybaev, A.B.; Ermagambetov, B.T.; Mamraeva, K.M.; Shin, R.G.; Bakirova, R.K. (Institut Organicheskogo Sinteza i Uglekhimii AN KazSSR (USSR))
1991-04-01
Describes production of lump fuel by briquetting and coking different mixtures of non-caking coal with coal preparation sludge and bitumen extracted from oil sands. The coal used was from the Shubarkol'sk coal deposit (USSR); the sludge was from the Saburkhanskaya preparation plant. Properties and composition of oil-bituminous sands and of bitumen to be used as binder are given. Technological details of the briquetting and coking processes are provided. Results show that briquets produced from mixtures of coal and oil-bituminous sands can only be used as a high-ash lump fuel, which cannot be further processed into semicoke. Experiments were carried out briquetting coal or coke, sludge and 6-8% bitumen extracted from the sands, varying coal or coke grain fractions and composition of the mixture. An increased briquet strength was found after using the vacuum-distilled 300-350 C bitumen fraction. Briquets from this non-caking coal with bitumen binder are regarded as ecologically clean fuel. 5 refs.
Modelling rogue waves through exact dynamical lump soliton controlled by ocean currents
Kundu, Anjan; Mukherjee, Abhik; Naskar, Tapan
2014-01-01
Rogue waves are extraordinarily high and steep isolated waves, which appear suddenly in a calm sea and disappear equally fast. However, though the rogue waves are localized surface waves, their theoretical models and experimental observations are available mostly in one dimension, with the majority of them admitting only limited and fixed amplitude and modular inclination of the wave. We propose two dimensions, exactly solvable nonlinear Schrödinger (NLS) equation derivable from the basic hydrodynamic equations and endowed with integrable structures. The proposed two-dimensional equation exhibits modulation instability and frequency correction induced by the nonlinear effect, with a directional preference, all of which can be determined through precise analytic result. The two-dimensional NLS equation allows also an exact lump soliton which can model a full-grown surface rogue wave with adjustable height and modular inclination. The lump soliton under the influence of an ocean current appears and disappears preceded by a hole state, with its dynamics controlled by the current term. These desirable properties make our exact model promising for describing ocean rogue waves. PMID:24711719
Directory of Open Access Journals (Sweden)
Bury Tomasz
2015-06-01
Full Text Available The problem of hydrogen behavior in containment buildings of nuclear reactors belongs to thermal-hydraulic area. Taking into account the size of systems under consideration and, first of all, safety issues, such type of analyses cannot be done by means of full-scale experiments. Therefore, mathematical modeling and numerical simulations are widely used for these purposes. A lumped parameter approach based code HEPCAL has been elaborated in the Institute of Thermal Technology of the Silesian University of Technology for simulations of pressurized water reactor containment transient response. The VVER-440/213 and European pressurised water reactor (EPR reactors containments are the subjects of analysis within the framework of this paper. Simulations have been realized for the loss-of-coolant accident scenarios with emergency core cooling system failure. These scenarios include core overheating and hydrogen generation. Passive autocatalytic recombiners installed for removal of hydrogen has been taken into account. The operational efficiency of the hydrogen removal system has been evaluated by comparing with an actual hydrogen concentration and flammability limit. This limit has been determined for the three-component mixture of air, steam and hydrogen. Some problems related to the lumped parameter approach application have been also identified.
Directory of Open Access Journals (Sweden)
Y. Tang
2007-01-01
Full Text Available This study seeks to identify sensitivity tools that will advance our understanding of lumped hydrologic models for the purposes of model improvement, calibration efficiency and improved measurement schemes. Four sensitivity analysis methods were tested: (1 local analysis using parameter estimation software (PEST, (2 regional sensitivity analysis (RSA, (3 analysis of variance (ANOVA, and (4 Sobol's method. The methods' relative efficiencies and effectiveness have been analyzed and compared. These four sensitivity methods were applied to the lumped Sacramento soil moisture accounting model (SAC-SMA coupled with SNOW-17. Results from this study characterize model sensitivities for two medium sized watersheds within the Juniata River Basin in Pennsylvania, USA. Comparative results for the 4 sensitivity methods are presented for a 3-year time series with 1 h, 6 h, and 24 h time intervals. The results of this study show that model parameter sensitivities are heavily impacted by the choice of analysis method as well as the model time interval. Differences between the two adjacent watersheds also suggest strong influences of local physical characteristics on the sensitivity methods' results. This study also contributes a comprehensive assessment of the repeatability, robustness, efficiency, and ease-of-implementation of the four sensitivity methods. Overall ANOVA and Sobol's method were shown to be superior to RSA and PEST. Relative to one another, ANOVA has reduced computational requirements and Sobol's method yielded more robust sensitivity rankings.
Zhang, Peng; Bao, Bingbing; Wang, Meng
2017-01-01
The vibration of robot joint reducer is the main factor that causes vibration or motion error of robot system. To improve the dynamic precision of robot system, the cycloid ball transmission used in robot joint is selected as study object in this paper. An efficient dynamic modelling method is presented-lumped stiffness method. Based on lumped stiffness method, a translational-torsional coupling dynamics model of cycloid ball transmission system is established. Mesh stiffness variation excitation, damping of system are all intrinsically considered in the model. The dynamic equation of system is derived by means of relative displacement relationship among different components. Then, the natural frequencies and vibration modes of the derivative system are presented by solving the associated eigenvalue problem. Finally, the influence of the main structural parameters on the natural frequency of the system is analysed. The present research can provide a new idea for dynamic analysis of robot joint reducer and provide a more simplify dynamic modelling method for robot system with joint reducer.
Energy Technology Data Exchange (ETDEWEB)
Lindroos, Alf, E-mail: alf.lindroos@abo.fi [Geology and Mineralogy, Department of Natural Sciences, Åbo Akademi University (Finland); Art History, Faculty of Art, Åbo Akademi University (Finland); Ranta, Heikki [Diocese of Lund, Church of Sweden (Sweden); Heinemeier, Jan [AMS " 1" 4C Dating Laboratory, Department of Physics and Astronomy, University of Aarhus (Denmark); Lill, Jan-Olof [Accelerator Laboratory, Turku PET Centre, Åbo Akademi University (Finland)
2014-07-15
Mortar dating was applied to newly revealed, original mortar in the church of Dalby in Scania, southern Sweden which is considered to be the oldest still standing church in Scandinavia. Small white lime lumps were sampled by chipping from the supporting pillars in the interior of the church. Special emphasis was in sampling lime lumps because the church is situated in the Scania limestone area and aggregate limestone contamination was anticipated in the bulk mortars. Earlier studies have, however, shown that lime lumps do not contain aggregate material but only possible limestone rests from incomplete calcination. The sampled material was prepared for radiocarbon AMS dating. The carbonate in the lime lumps was hydrolyzed according to the sequential leaching technique developed for the Århus {sup 14}C laboratory in Denmark. Prior to the hydrolysis the lime lumps were examined for dead-carbon contamination using a stereo microscope and cathodoluminescence. The lime lumps displayed heterogeneous carbonate luminescence. This is, however, common and it was not considered a problem because carbonate growth in changing pH/Eh conditions often leads to changing luminescence colors. Two lumps had little dead carbon contamination and an early second millennium {sup 14}C signature. One lump, however, seemed to be heavily contaminated with dead carbon. Since the sample passed the microscopic screening, the leftovers of the lump was subjected to PIXE analysis and compared with the other two lumps. The well-defined, early 2nd millennium {sup 14}C age of the lime lumps of this particular church is an important contribution to the discussion on stone church chronology in Scandinavia.
Energy Technology Data Exchange (ETDEWEB)
Cernosek, R.W.; Martin, S.J. [Sandia National Laboratories, Albuquerque, NM (United States); Hillman, A.R. [Univ. of Leicester (United Kingdom). Dept. of Chemistry] [and others
1997-08-01
Both a transmission-line model and its simpler variant, a lumped-element model, can be used to predict the responses of a thickness-shear-mode quartz resonator sensor. Relative deviations in the parameters computed by the two models (shifts in resonant frequency and motional resistance) do not exceed 3% for most practical sensor configurations operating at the fundamental resonance. If the ratio of the load surface mechanical impedance to the quartz shear characteristic impedance does not exceed 0.1, the lumped-element model always predicts responses within 1% of those for the transmission-line model.
International Nuclear Information System (INIS)
Baup, Olivier
2001-01-01
The aim of this work was to study the TIG multipass welding process on stainless steel, by means of numerical methods and then to work out simplified and bead lumping methods in order to reduce adjusting and realisation times of these calculations. A simulation was used as reference for the validation of these methods; after the presentation of the test series having led to the option choices of this calculation (2D generalised plane strains, elastoplastic model with an isotropic hardening, hardening restoration due to high temperatures), various simplifications were tried on a plate geometry. These simplifications related various modelling points with a correct plastic flow representation in the plate. The use of a reduced number of thermal fields characterising the bead deposit and a low number of tensile curves allow to obtain interesting results, decreasing significantly the Computing times. In addition various lumping bead methods have been studied and concerning both the shape and the thermic of the macro-deposits. The macro-deposit shapes studied are in 'L', or in layer or they represent two beads one on top of the other. Among these three methods, only those using a few number of lumping beads gave bad results since thermo-mechanical history was deeply modified near and inside the weld. Thereafter, simplified methods have been applied to a tubular geometry. On this new geometry, experimental measurements were made during welding, which allow a validation of the reference calculation. Simplified and reference calculations gave approximately the same stress fields as found on plate geometry. Finally, in the last part of this document a procedure for automatic data setting permitting to reduce significantly the calculation phase preparation is presented. It has been applied to the calculation of thick pipe welding in 90 beads; the results are compared with a simplified simulation realised by Framatome and with experimental measurements. A bead by
Assessment of strategy formulation
DEFF Research Database (Denmark)
Acur, Nuran; Englyst, Linda
2006-01-01
approaches to strategy assessment, namely the goal-centred, comparative and improvement approaches, as found in the literature. Furthermore, it encompasses three phases of strategy formulation processes: strategic thinking, strategic planning and embedding of strategy. The tool reflects that the different......, but cases and managerial perceptions indicate that the need for accurate and detailed plans might be overrated in the literature, as implementation relies heavily on continuous improvement and empowerment. Concerning embedding, key aspects relate both to the goal-centred and improvement approaches, while...... for strategy formulation processes that ensures high quality in process and outcome. Design/methodology/approach – A literature review was conducted to identify success criteria for strategy formulation processes. Then, a simple questionnaire and assessment tool was developed and used to test the validity...
International Nuclear Information System (INIS)
Luescher, M.; Pohlmeyer, K.
1977-09-01
Finite energy solutions of the field equations of the non-linear sigma-model are shown to decay asymptotically into massless lumps. By means of a linear eigenvalue problem connected with the field equations we then find an infinite set of dynamical conserved charges. They, however, do not provide sufficient information to decode the complicated scattering of lumps. (orig.) [de
Ogden, Fred L.; Hawkins, Richard Pete; Walter, M. Todd; Goodrich, David C.
2017-07-01
Bartlett et al. (2016) performed a re-interpretation and modification of the space-time lumped USDA NRCS (formerly SCS) Curve Number (CN) method to extend its applicability to forested watersheds. We believe that the well documented limitations of the CN method severely constrains the applicability of the modifications proposed by Bartlett et al. (2016). This forward-looking comment urges the research communities in hydrologic science and engineering to consider the CN method as a stepping stone that has outlived its usefulness in research. The CN method fills a narrow niche in certain settings as a parsimonious method having utility as an empirical equation to estimate runoff from a given amount of rainfall, which originated as a static functional form that fits rainfall-runoff data sets. Sixty five years of use and multiple reinterpretations have not resulted in improved hydrological predictability using the method. We suggest that the research community should move forward by (1) identifying appropriate dynamic hydrological model formulations for different hydro-geographic settings, (2) specifying needed model capabilities for solving different classes of problems (e.g., flooding, erosion/sedimentation, nutrient transport, water management, etc.) in different hydro-geographic settings, and (3) expanding data collection and research programs to help ameliorate the so-called "overparameterization" problem in contemporary modeling. Many decades of advances in geo-spatial data and processing, computation, and understanding are being squandered on continued focus on the static CN regression method. It is time to truly "move beyond" the Curve Number method.
Lubrication in tablet formulations.
Wang, Jennifer; Wen, Hong; Desai, Divyakant
2010-05-01
Theoretical aspects and practical considerations of lubrication in tablet compression are reviewed in this paper. Properties of the materials that are often used as lubricants, such as magnesium stearate, in tablet dosage form are summarized. The manufacturing process factors that may affect tablet lubrication are discussed. As important as the lubricants in tablet formulations are, their presence can cause some changes to the tablet physical and chemical properties. Furthermore, a detailed review is provided on the methodologies used to characterize lubrication process during tablet compression with relevant process analytical technologies. Finally, the Quality-by-Design considerations for tablet formulation and process development in terms of lubrication are discussed.
Energy Technology Data Exchange (ETDEWEB)
Angerer, Andreas, E-mail: andreas.angerer@tuwien.ac.at; Astner, Thomas; Wirtitsch, Daniel; Majer, Johannes, E-mail: johannes.majer@tuwien.ac.at [Vienna Center for Quantum Science and Technology, Atominstitut, TU Wien, Stadionallee 2, 1020 Vienna (Austria); Sumiya, Hitoshi [Sumitomo Electric Industries Ltd., Itami 664-001 (Japan); Onoda, Shinobu [Takasaki Advanced Radiation Research Institute, National Institutes for Quantum and Radiological Science and Technology, 1233 Watanuki, Takasaki, Gunma 370-1292 (Japan); Isoya, Junichi [Research Centre for Knowledge Communities, University of Tsukuba, 1-2 Kasuga, Tsukuba, Ibaraki 305-8550 (Japan); Putz, Stefan [Vienna Center for Quantum Science and Technology, Atominstitut, TU Wien, Stadionallee 2, 1020 Vienna (Austria); Department of Physics, Princeton University, Princeton, New Jersey 08544 (United States)
2016-07-18
We design and implement 3D-lumped element microwave cavities that spatially focus magnetic fields to a small mode volume. They allow coherent and uniform coupling to electron spins hosted by nitrogen vacancy centers in diamond. We achieve large homogeneous single spin coupling rates, with an enhancement of more than one order of magnitude compared to standard 3D cavities with a fundamental resonance at 3 GHz. Finite element simulations confirm that the magnetic field distribution is homogeneous throughout the entire sample volume, with a root mean square deviation of 1.54%. With a sample containing 10{sup 17} nitrogen vacancy electron spins, we achieve a collective coupling strength of Ω = 12 MHz, a cooperativity factor C = 27, and clearly enter the strong coupling regime. This allows to interface a macroscopic spin ensemble with microwave circuits, and the homogeneous Rabi frequency paves the way to manipulate the full ensemble population in a coherent way.
A passive terahertz video camera based on lumped element kinetic inductance detectors
Energy Technology Data Exchange (ETDEWEB)
Rowe, Sam, E-mail: sam.rowe@astro.cf.ac.uk; Pascale, Enzo; Doyle, Simon; Dunscombe, Chris; Hargrave, Peter; Papageorgio, Andreas; Ade, Peter A. R.; Barry, Peter; Bideaud, Aurélien; Brien, Tom; Dodd, Chris; House, Julian; Moseley, Paul; Sudiwala, Rashmi; Tucker, Carole; Walker, Ian [Astronomy Instrumentation Group, School of Physics and Astronomy, Cardiff University, Cardiff CF24 3AA (United Kingdom); Wood, Ken [QMC Instruments Ltd., School of Physics and Astronomy, Cardiff University, Cardiff CF24 3AA (United Kingdom); Grainger, William [Rutherford Appleton Laboratory, STFC, Swindon SN2 1SZ (United Kingdom); Mauskopf, Philip [Astronomy Instrumentation Group, School of Physics and Astronomy, Cardiff University, Cardiff CF24 3AA (United Kingdom); School of Earth Science and Space Exploration, Arizona State University, Tempe, Arizona 85281 (United States); Spencer, Locke [Department of Physics and Astronomy, University of Lethbridge, Lethbridge, Alberta T1K 3M4 (Canada)
2016-03-15
We have developed a passive 350 GHz (850 μm) video-camera to demonstrate lumped element kinetic inductance detectors (LEKIDs)—designed originally for far-infrared astronomy—as an option for general purpose terrestrial terahertz imaging applications. The camera currently operates at a quasi-video frame rate of 2 Hz with a noise equivalent temperature difference per frame of ∼0.1 K, which is close to the background limit. The 152 element superconducting LEKID array is fabricated from a simple 40 nm aluminum film on a silicon dielectric substrate and is read out through a single microwave feedline with a cryogenic low noise amplifier and room temperature frequency domain multiplexing electronics.
International Nuclear Information System (INIS)
Tai, D.; Underhill, G.K.
1975-01-01
The Boltzmann integrodifferential neutron transport equation has been converted to an integral equation which incorporates the isotropic neutron bath boundary condition. The resulting integral equation is solved using the discrete ordinates method, resulting in solutions for the spatially-dependent and -independent fluxes in terms of transport probabilities and the neutron emission density. The transport probabilities and the lethargy-dependence solution are evaluated using a normalization condition and a neutron conservation equation, respectively, to correct for inherent error propagation. The formalism is applied to the calculation of uranium resonance integrals for a spherical, two-region lump consisting of a spherical absorber surrounded by a spherical cadmium cover. Calculated and experimental results for uranium-235 fission and uranium-238 capture resonance integrals compare favorably. 11 references. (U.S.)
General 3D Lumped Thermal Model with Various Boundary Conditions for High Power IGBT Modules
DEFF Research Database (Denmark)
Bahman, Amir Sajjad; Ma, Ke; Blaabjerg, Frede
2016-01-01
Accurate thermal dynamics modeling of high power Insulated Gate Bipolar Transistor (IGBT) modules is important information for the reliability analysis and thermal design of power electronic systems. However, the existing thermal models have their limits to correctly predict these complicated...... thermal behaviors in the IGBTs. In this paper, a new three-dimensional (3D) lumped thermal model is proposed, which can easily be characterized from Finite Element Methods (FEM) based simulation and acquire the thermal distribution in critical points. Meanwhile the boundary conditions including...... the cooling system and power losses are modeled in the 3D thermal model, which can be adapted to different real field applications of power electronic converters. The accuracy of the proposed thermal model is verified by experimental results....
A numerical investigation of the GRLW equation using lumped Galerkin approach with cubic B-spline.
Zeybek, Halil; Karakoç, S Battal Gazi
2016-01-01
In this work, we construct the lumped Galerkin approach based on cubic B-splines to obtain the numerical solution of the generalized regularized long wave equation. Applying the von Neumann approximation, it is shown that the linearized algorithm is unconditionally stable. The presented method is implemented to three test problems including single solitary wave, interaction of two solitary waves and development of an undular bore. To prove the performance of the numerical scheme, the error norms [Formula: see text] and [Formula: see text] and the conservative quantities [Formula: see text], [Formula: see text] and [Formula: see text] are computed and the computational data are compared with the earlier works. In addition, the motion of solitary waves is described at different time levels.
The welfare gain from replacing the health insurance tax exclusion with lump-sum tax credits.
Liu, Liqun; Rettenmaier, Andrew J; Saving, Thomas R
2011-06-01
This paper analyzes the welfare gain from replacing the tax exclusion of employer-provided health insurance with a lump-sum tax credit. It differs from earlier studies in that we look at the welfare cost of health insurance tax exclusion as coming directly from excessive health insurance rather than from overconsumption of medical care and that we account for the labor market effect of the tax exclusion on welfare. Both differences work to produce a smaller tax reform welfare gain. For a set of mid-range parameter values, the welfare gain is about 21% of current health insurance tax expenditures. In addition, government tax expenditures would fall by 38%, and health insurance spending would fall by 77% after the reform.
Lumped Parameter Models of the Central Nervous System for VIIP Research
Vera, J.; Mulugeta, L.; Nelson, E. S.; Raykin, J.; Feola, A.; Gleason, R.; Samuels, B.; Myers, J. G.
2015-01-01
INTRODUCTION: Current long-duration missions to the International Space Station and future exploration-class missions beyond low-Earth orbit, such as to Mars and asteroids, expose astronauts to increased risk of Visual Impairment and Intracranial Pressure (VIIP) syndrome [1]. It has been hypothesized that the headward shift of cerebral spinal fluid (CSF) and blood in microgravity may cause significant elevation of intracranial pressure (ICP), which in turn induces VIIP syndrome through biomechanical pathways [1, 2]. However, there is insufficient evidence to confirm this hypothesis. In this light, we are developing lumped-parameter models of fluid transport in the central nervous system (CNS) as a means to simulate the influence of microgravity on ICP. The CNS models will also be used in concert with the lumped parameter and finite element models of the eye described in the realted IWS abstracts submitted by Nelson et al., Feola et al. and Ethier et al. METHODS: We have developed a nine compartment CNS model (Figure 1) capable of both time-dependent and steady state fluid transport simulations, based on the works of Stevens et al. [3]. The breakdown of compartments within the model includes: vascular (3), CSF (2), brain (1) and extracranial (3). The boundary pressure in the Central Arteries [A] node is prescribed using an oscillating pressure function PA(t) simulating the carotid pulsatile pressure wave as developed by Linninger et al. [4]. For each time step, pressures are integrated through time using an adaptive-timestep 4th and 5th order Runga-Kutta solver. Once pressures are found, constitutive equations are used to solve for flowrates (Q) between each compartment. In addition to fluid flow between the different compartments, compliance (C) interactions between neighboring compartments are represented. We are also developing a second CNS model based on the works of Linninger et al. [4] which takes a more granular approach to represent the interactions of the
La (autorepresentación en ruinas: Lumpérica de Diamela Eltit
Directory of Open Access Journals (Sweden)
Eva Klein
2014-06-01
Full Text Available Acaso se vuelve necesario revisar cómo responden las narraciones en primera persona al derrumbe de las verdades hegemónicas, y cómo se apuesta a la (autorepresentación cuando se da por sentado que entre las estrategias discursivas y los juegos de poder se traman pactos rigurosos. Por otro lado, se vuelve pertinente preguntar qué valor se le puede dar a las (autorepresentaciones cuando ya no confiamos en las identidades normativas y sabemos que toda lectura del pasado está atravesada por complejas políticas de la memoria y cómplices técnicas de olvido. Para intentar dar respuestas a estas interrogantes, he escogido un texto que ensaya una escritura de fuertes marcas neo-vanguardistas: Lumpérica (1983, de Diamela Eltit.
Unusual Presentation of Hydatidosis - Neck Lump Causing Costo-Vertebral Erosion.
Alam, Mehtab; Hasan, Syed-Abrar; Hashmi, Shahab-Farkhund
2016-09-01
Hydatid disease caused by larval stage of Echinococcus has been recognized endemically in many countries. Liver and lungs are the most commonly affected organs. Involvement of the head and neck region is rare and bony erosion due to hydatidosis is even rarer. We report a case of a 17-year-old girl from a poor socio-economic background who presented with a right sided supraclavicular lump, which after surgical excision and histopathological examination was diagnosed as hydatid cyst of neck. Because of its rarity in the neck region, primary diagnosis of hydatid cyst is overlooked and usually not included in the differential diagnosis of cystic neck swellings. A high index of suspicion is necessary to diagnose hydatid disease in an unusual location even in endemic areas.
INCIDENCE OF BENIGN BREAST LUMP ABOVE 40 YRS. OF AGE IN FEMALE ATTENDING MGMGH, TIRUCHIRAPPALLI
Directory of Open Access Journals (Sweden)
Ayyaswamy Thulasi
2016-10-01
Full Text Available BACKGROUND AND OBJECTIVES The breast is the essential symbol of womanhood to society and to the woman herself. Subjected every month to the onslaught of ovarian, adrenal, pituitary and thyroid hormones in tandem with the uterus, the very histological architecture of the breast changes sequentially. With the recent importance given to early diagnosis of cancer of the breast and its early detection by both the patient and her physician, more benign conditions are likely to be detected than earlier. The objective of our review is to find out the incidence of benign breast lump above 40 years of age in females attending our hospital. METHODS AND MATERIALS 130 patients presenting to the outpatient department of KAPV Medical College with breast lump were included in this comprehensive study. A detailed history regarding the duration and nature of the complaints, family history pertaining to breast or ovarian cancers, risk factors such as oral contraceptive use, parity, lactation, etc. was elicited. A thorough clinical examination was performed. RESULTS Of 24 cases of fibroadenoma, all were operated upon by excision. Of 38 patients with fibroadenosis, 30 patients managed conservatively and surgery for 8 patients where the diagnosis was doubtful. Abscesses were incised and drained under antibiotic cover for 3 patients. 8 cases of breast cyst were managed by aspiration. TB mastitis was confirmed by excisional biopsy and followed up by antituberculous therapy with regular follow up after 6 months. Healed lesions were found to be associated with improved general condition of the patients. Lipoma and sebaceous cyst were managed by excision biopsy. CONCLUSION Benign breast diseases were found to be common in woman above 40 years old in contrast to normal teaching, which says they are common in younger age groups. Fibroadenosis was the commonest benign disease closely followed by fibroadenoma. Fibroadenosis was mostly managed conservatively. Excision biopsy
Van Dyke, Michael B.
2014-01-01
During random vibration testing of electronic boxes there is often a desire to know the dynamic response of certain internal printed wiring boards (PWBs) for the purpose of monitoring the response of sensitive hardware or for post-test forensic analysis in support of anomaly investigation. Due to restrictions on internally mounted accelerometers for most flight hardware there is usually no means to empirically observe the internal dynamics of the unit, so one must resort to crude and highly uncertain approximations. One common practice is to apply Miles Equation, which does not account for the coupled response of the board in the chassis, resulting in significant over- or under-prediction. This paper explores the application of simple multiple-degree-of-freedom lumped parameter modeling to predict the coupled random vibration response of the PWBs in their fundamental modes of vibration. A simple tool using this approach could be used during or following a random vibration test to interpret vibration test data from a single external chassis measurement to deduce internal board dynamics by means of a rapid correlation analysis. Such a tool might also be useful in early design stages as a supplemental analysis to a more detailed finite element analysis to quickly prototype and analyze the dynamics of various design iterations. After developing the theoretical basis, a lumped parameter modeling approach is applied to an electronic unit for which both external and internal test vibration response measurements are available for direct comparison. Reasonable correlation of the results demonstrates the potential viability of such an approach. Further development of the preliminary approach presented in this paper will involve correlation with detailed finite element models and additional relevant test data.
Nakai, H; Matsuda, H; Takara, E; Diksic, M; Meyer, E; Yamamoto, Y L
1987-01-01
Lumped and transfer rate constants in ischemic brain tissue must be measured to estimate accurately cerebral glucose utilization by the deoxyglucose method. We studied the bilateral middle cerebral artery occlusion model in 17 cats, 5 with a 1-hour occlusion, 5 with a 4-hour occlusion, and 7 with a sham operation. The time course of cerebral tissue radioactivity (Ci*(t)) was monitored by external coincidence counting during a programmed infusion of [18F]-2-deoxy-2-fluoro-d-glucose (18F-2-FDG). Arterial plasma concentration (Cp*(t)) of the tracer was kept constant during the first 45 minutes. Rate constants were estimated from Ci*(t) and Cp*(t) by a nonlinear least-squares fitting routine. The lumped constant was estimated from the fit of the ratio of extraction fractions of glucose and 18F-2-FDG by nonweighted, nonlinear least-squares fitting. In the 4-hour-occlusion model, the transfer constant k1* was 23% lower, k3* 39% lower, and the lumped constant 78% higher than in the sham-operated animals. In the 1-hour-occlusion model, k3* was 26% lower than in the sham-operated animals but the lumped constant was not significantly different. The rate of glucose utilization was significantly different in the 4-hour-occlusion model compared to the sham-operated animals (48% decrease, p less than 0.05) but was not significantly different in the 1-hour-occlusion model.
International Nuclear Information System (INIS)
Wambsganss, M.W.
1989-01-01
In this technical note, mass-spring-dashpot, also referred to as equivalent lumped parameter, models are employed to model the soil-foundation interaction of two typical floor segments from the 7-GeV APS experiment hall. Equivalent lumped parameter models have the advantage of being easy to apply and of readily allowing for parameter studies. Analysis requires knowledge of certain properties of the soil including density, shear wave velocity, and Poisson's ratio, as well as knowledge of the degree of homogeneity of the underlying soil stratum. These data for the APS site were determined by a geotechnical investigation. A soil profile and pertinent data, obtained from crosshole seismic testing, are given. Natural frequencies and damping are calculated for the vertical, sliding, rocking, and coupled rocking/sliding modes of vibration. Subsequently, various corrections to account for modeling ''deficiencies'' are considered and their influences evaluated. The equivalent lumped parameter models were developed for machine foundations which, compared with the APS foundation, are smaller in plan dimension. Therefore, the applicability of these models in the analysis of the dynamic characteristics of the APS foundation must be established. The modeling is evaluated by applying the equivalent lumped parameter models in the analysis of large foundations for which test data exists. A comparison of theoretical and test results establishes the basis for an assessment of the applicability and accuracy of the modeling
Energy Technology Data Exchange (ETDEWEB)
Mathews, Jonathan P. [Department of Energy and Mineral Engineering, Pennsylvania State University, University Park, PA (United States); EMS Energy Institute, University Park, PA (United States); Pone, J. Denis N. [ConocoPhilips Technology Center, Bartlesville, Oklahoma (United States); Mitchell, Gareth D.; Halleck, Phillip [EMS Energy Institute, University Park, PA (United States)
2011-01-15
Drying of low-rank coals affects: coal cleaning, combustion, comminution, gasification, liquefaction, and in-seam fluid-flow (water, coalbed methane, and carbon dioxide for sequestration/enhanced coalbed methane). To evaluate the extent of drying-induced transitions, 3 lump-sized (approximately 6 x 2 x 2 cm) Powder River Basin subbituminous coal samples were thermally dried in an air-drying coal oven at 50 C over two weeks. A high-resolution industrial X-ray computed tomography scanner was utilized to generate (non-destructively) three-dimensional regional volumetric renderings, as-received and over 3-stages of drying. The lumps had cleats, both open and mineral filled, with a degree of fracture diversity along the longitudinal plane. Comparison of the virtual slice surfaces, at identifiable locations, allowed the induced cracking and shrinkage accompanying the transitions during 19% moisture loss to almost dry to be observed. Under these drying conditions, the heat transfer, and thus extent of drying, proceeded radially inward. With increased drying time the fractures extend and become larger in aperture as the coal shrinks. The major fractures mostly followed the existing cleat system. With additional drying, these cleats widened and the aperture increase propagated deeper into the coal extended into the butt cleats. New fractures were located mostly perpendicular to the cleat fracture surface. The external volume of the coal lumps had limited shrinkage. The axial extent of the shrinkage length (lump edge to lump edge) was on the order of 4-6%, the bulk of the shrinkage being accommodated by the internal shrinkage between cleats. (author)
Rao, Jiguang; Porsezian, Kuppuswamy; He, Jingsong; Kanna, Thambithurai
2018-01-01
General semi-rational solutions of an integrable multi-component (2+1)-dimensional long-wave-short-wave resonance interaction system comprising multiple short waves and a single long wave are obtained by employing the bilinear method. These solutions describe the interactions between various types of solutions, including line rogue waves, lumps, breathers and dark solitons. We only focus on the dynamical behaviours of the interactions between lumps and dark solitons in this paper. Our detailed study reveals two different types of excitation phenomena: fusion and fission. It is shown that the fundamental (simplest) semi-rational solutions can exhibit fission of a dark soliton into a lump and a dark soliton or fusion of one lump and one dark soliton into a dark soliton. The non-fundamental semi-rational solutions are further classified into three subclasses: higher-order, multi- and mixed-type semi-rational solutions. The higher-order semi-rational solutions show the process of annihilation (production) of two or more lumps into (from) one dark soliton. The multi-semi-rational solutions describe N ( N ≥2) lumps annihilating into or producing from N -dark solitons. The mixed-type semi-rational solutions are a hybrid of higher-order semi-rational solutions and multi-semi-rational solutions. For the mixed-type semi-rational solutions, we demonstrate an interesting dynamical behaviour that is characterized by partial suppression or creation of lumps from the dark solitons.
Systematic Equation Formulation
DEFF Research Database (Denmark)
Lindberg, Erik
2007-01-01
A tutorial giving a very simple introduction to the set-up of the equations used as a model for an electrical/electronic circuit. The aim is to find a method which is as simple and general as possible with respect to implementation in a computer program. The “Modified Nodal Approach”, MNA, and th......, and the “Controlled Source Approach”, CSA, for systematic equation formulation are investigated. It is suggested that the kernel of the P Spice program based on MNA is reprogrammed....
Parameter sensitivity analysis of a lumped-parameter model of a chain of lymphangions in series.
Jamalian, Samira; Bertram, Christopher D; Richardson, William J; Moore, James E
2013-12-01
Any disruption of the lymphatic system due to trauma or injury can lead to edema. There is no effective cure for lymphedema, partly because predictive knowledge of lymphatic system reactions to interventions is lacking. A well-developed model of the system could greatly improve our understanding of its function. Lymphangions, defined as the vessel segment between two valves, are the individual pumping units. Based on our previous lumped-parameter model of a chain of lymphangions, this study aimed to identify the parameters that affect the system output the most using a sensitivity analysis. The system was highly sensitive to minimum valve resistance, such that variations in this parameter caused an order-of-magnitude change in time-average flow rate for certain values of imposed pressure difference. Average flow rate doubled when contraction frequency was increased within its physiological range. Optimum lymphangion length was found to be some 13-14.5 diameters. A peak of time-average flow rate occurred when transmural pressure was such that the pressure-diameter loop for active contractions was centered near maximum passive vessel compliance. Increasing the number of lymphangions in the chain improved the pumping in the presence of larger adverse pressure differences. For a given pressure difference, the optimal number of lymphangions increased with the total vessel length. These results indicate that further experiments to estimate valve resistance more accurately are necessary. The existence of an optimal value of transmural pressure may provide additional guidelines for increasing pumping in areas affected by edema.
Karam, Ayman M.
2016-10-03
Membrane distillation (MD) is an emerging technology that has a great potential for sustainable water desalination. In order to pave the way for successful commercialization of MD-based water desalination techniques, adequate and accurate dynamical models of the process are essential. This paper presents the predictive capabilities of a lumped-parameter dynamic model for direct contact membrane distillation (DCMD) and discusses the results under wide range of steady-state and dynamic conditions. Unlike previous studies, the proposed model captures the time response of the spacial temperature distribution along the flow direction. It also directly solves for the local temperatures at the membrane interfaces, which allows to accurately model and calculate local flux values along with other intrinsic variables of great influence on the process, like the temperature polarization coefficient (TPC). The proposed model is based on energy and mass conservation principles and analogy between thermal and electrical systems. Experimental data was collected to validated the steady-state and dynamic responses of the model. The obtained results shows great agreement with the experimental data. The paper discusses the results of several simulations under various conditions to optimize the DCMD process efficiency and analyze its response. This demonstrates some potential applications of the proposed model to carry out scale up and design studies. © 2016
A Lip Lump: An Unexpected Histological Diagnosis of a Lip Schwannoma
Directory of Open Access Journals (Sweden)
Thomas Haigh
2017-01-01
Full Text Available Schwannomas are benign nerve sheath tumours arising from Schwann cells. They comprise 1% of all benign tumours. In the 2016 World Health Organisation Classification of Central Nervous System, they are classified as a tumour of the cranial and paraspinal nerves, Schwannoma 9560/0. A 23-year-old Caucasian lady presented with a seven-month history of a painless right upper lip lump. Examination revealed a small cystic 0.5 cm diameter lesion within the right upper lip. The clinical impression was that of a mucocele. Excision of the lip lesion was performed under local anaesthetic. Histological examination of the excised lesion demonstrated a circumscribed nodule consisting of spindle cells mixed with vascular spaces containing red blood cells and fibrin. Immunohistochemistry for S100 was strongly positive. The findings were consistent with that of a small benign schwannoma. The current consensus is for surgical excision of a conservative nature with no need for margins. If recurrence does occur one needs to consider whether complete enucleation was achieved or whether malignant transformation has occurred.
International Nuclear Information System (INIS)
Annor-Nyarko, M.; Ayensu Gyeabour, I.; Akaho, E. H. K.
2013-01-01
Lumped thermal capacitance analysis has been undertaken to investigate the transient temperature variations, associated induced thermal stress distributions, and the structural integrity of Ghana Research Reactor-I (GHAR R-I) vessel after 15 years of operation. The beltline configuration of the cylindrical vessel of the Miniature Neutron Source Reactor (MNSR) was based on thin-shell and axi-symmetric assumptions with small temperature gradient and low Biot number. The thermal energy transferred by unsteady flow of the coolant to the vessel was determined as internal energy change. Numerical algorithms for Matlab Code were implemented to generate data for transient analysis and simulation. The simulations indicated that the temperature variations and the thermal stresses were below the limits imposed by the vessel material (Aluminium alloy LT 21) specifications of 933 K melting point and allowable yield stress of 480 MPa. The low level of induced thermal stresses indicated that the structural integrity of the reactor vessel has been maintained to forestall any incidence of crack propagation and fatigue failure over the operation period. (au)
Frequency Combs in a Lumped-Element Josephson-Junction Circuit
Khan, Saeed; Türeci, Hakan E.
2018-04-01
We investigate the dynamics of a microwave-driven Josephson junction capacitively coupled to a lumped-element L C oscillator. In the regime of driving where the Josephson junction can be approximated as a Kerr oscillator, this minimal nonlinear system has been previously shown to exhibit a bistability in phase and amplitude. In the present study, we characterize the full phase diagram and show that besides a parameter regime exhibiting bistability, there is also a regime of self-oscillations characterized by a frequency comb in its spectrum. We discuss the mechanism of comb generation which appears to be different from those studied in microcavity frequency combs and mode-locked lasers. We then address the fate of the comblike spectrum in the regime of strong quantum fluctuations, reached when nonlinearity becomes the dominant scale with respect to dissipation. We find that the nonlinearity responsible for the emergence of the frequency combs also leads to its dephasing, leading to broadening and ultimate disappearance of sharp spectral peaks. Our study explores the fundamental question of the impact of quantum fluctuations for quantum systems which do not possess a stable fixed point in the classical limit.
Lumped element kinetic inductance detectors based on two-gap MgB2 thin films
Yang, C.; Niu, R. R.; Guo, Z. S.; Cai, X. W.; Chu, H. M.; Yang, K.; Wang, Y.; Feng, Q. R.; Gan, Z. Z.
2018-01-01
Lumped element kinetic inductance detectors (LEKIDs) are made from a single layer superconducting thin film. Because of their low noise and highly multiplexibility, LEKIDs provide a sensitive technology for the detection of millimeter and submillimeter waves. In this work, a 5-pixel 50-nm-thick MgB2 array is made. The microwave properties of the array are measured under dark conditions. We show that the loaded quality factor Q of the resonant circuit is 30 000 at 7.5 K, which is comparable to that of lower-operating-temperature (usually several hundred mK) LEKIDs made from superconductors such as Al and Nb. Moreover, the temperature dependence of resonance frequency gives the two-gap character of MgB2, Δπ (0) = 2.58 meV and Δσ (0) = 8.26 meV. The gap frequency (f = 2Δ/h) indicates that MgB2 LEKIDs have a promising application on terahertz detection.
Impact of atrial fibrillation on the cardiovascular system through a lumped-parameter approach.
Scarsoglio, Stefania; Guala, Andrea; Camporeale, Carlo; Ridolfi, Luca
2014-11-01
Atrial fibrillation (AF) is the most common arrhythmia affecting millions of people in the Western countries and, due to the widespread impact on the population and its medical relevance, is largely investigated in both clinical and bioengineering sciences. However, some important feedback mechanisms are still not clearly established. The present study aims at understanding the global response of the cardiovascular system during paroxysmal AF through a lumped-parameter approach, which is here performed paying particular attention to the stochastic modeling of the irregular heartbeats and the reduced contractility of the heart. AF can be here analyzed by means of a wide number of hemodynamic parameters and avoiding the presence of other pathologies, which usually accompany AF. Reduced cardiac output with correlated drop of ejection fraction and decreased amount of energy converted to work by the heart during blood pumping, as well as higher left atrial volumes and pressures are some of the most representative results aligned with the existing clinical literature and here emerging during acute AF. The present modeling, providing new insights on cardiovascular variables which are difficult to measure and rarely reported in literature, turns out to be an efficient and powerful tool for a deeper comprehension and prediction of the arrythmia impact on the whole cardiovascular system.
A simplified lumped model for the optimization of post-buckled beam architecture wideband generator
Liu, Weiqun; Formosa, Fabien; Badel, Adrien; Hu, Guangdi
2017-11-01
Buckled beams structures are a classical kind of bistable energy harvesters which attract more and more interests because of their capability to scavenge energy over a large frequency band in comparison with linear generator. The usual modeling approach uses the Galerkin mode discretization method with relatively high complexity, while the simplification with a single-mode solution lacks accuracy. It stems on the optimization of the energy potential features to finally define the physical and geometrical parameters. Therefore, in this paper, a simple lumped model is proposed with explicit relationship between the potential shape and parameters to allow efficient design of bistable beams based generator. The accuracy of the approximation model is studied with the effectiveness of application analyzed. Moreover, an important fact, that the bending stiffness has little influence on the potential shape with low buckling level and the sectional area determined, is found. This feature extends the applicable range of the model by utilizing the design of high moment of inertia. Numerical investigations demonstrate that the proposed model is a simple and reliable tool for design. An optimization example of using the proposed model is demonstrated with satisfactory performance.
Linear stability analysis of a nuclear reactor using the lumped model
Directory of Open Access Journals (Sweden)
Kale Vivek A.
2016-01-01
Full Text Available The stability analysis of a nuclear reactor is an important aspect in the design and operation of the reactor. A stable neutronic response to perturbations is essential from the safety point of view. In this paper, a general methodology has been developed for the linear stability analysis of nuclear reactors using the lumped reactor model. The reactor kinetics has been modelled using the point kinetics equations and the reactivity feedbacks from fuel, coolant and xenon have been modelled through the appropriate time dependent equations. These governing equations are linearized considering small perturbations in the reactor state around a steady operating point. The characteristic equation of the system is used to establish the stability zone of the reactor considering the reactivity coefficients as parameters. This methodology has been used to identify the stability region of a typical pressurized heavy water reactor. It is shown that the positive reactivity feedback from xenon narrows down the stability region. Further, it is observed that the neutron kinetics parameters (such as the number of delayed neutron precursor groups considered, the neutron generation time, the delayed neutron fractions, etc. do not have a significant influence on the location of the stability boundary. The stability boundary is largely influenced by the parameters governing the evolution of the fuel and coolant temperature and xenon concentration.
Determination of gold in lump by the gamma-activation analysis method
International Nuclear Information System (INIS)
Yantsen, V.A.; Ermakov, K.S.
2006-01-01
Full text: In the report the installation is described used in the Central gamma-activation analysis laboratory (CGAAL) for express quantitative determination of gold concentration in large powdered samples. The method of gold contents determination for non-crushed samples (pieces up to 100 mm). The given gamma-activation analysis method is widely used in mining industry, and at researches related with selection of optimal technological circuits designed for sorting the pieces of ore and rock materials. By developing this method it is now possible to create the technological collection of separated pieces by size, large by the amount of samples, imitating various sorts (by gold concentration in them) and types (by elemental composition) ores, and, based on these collection, to compare the efficiencies of various enrichment methods by knowing in advance the concentrations of gold in these lumps being the final sorting products. The Gamma-activation analysis method of large pieces is mainly used as foundation for the x-ray radiometric (XRR) method of pieces separation of gold-bearing ores from the deposits mined by the Navoi mining combine. It allows significant increase in the rate of research and development works on selection of the most reliable separation characteristics. Based on these one can develop optimal technological circuits for ore enrichment with portion sorting methods. (author)
Lumped mass model of a 1D metastructure for vibration suppression with no additional mass
Reichl, Katherine K.; Inman, Daniel J.
2017-09-01
The article examines the effectiveness of metastructures for vibration suppression from a weight standpoint. Metastructures, a metamaterial inspired concept, are structures with distributed vibration absorbers. In automotive and aerospace industries, it is critical to have low levels of vibrations while also using lightweight materials. Previous work has shown that metastructures are effective at mitigating vibrations, but do not consider the effects of mass. This work takes mass into consideration by comparing a structure with vibration absorbers to a structure of equal mass with no absorbers. These structures are modeled as one-dimensional lumped mass models, chosen for simplicity. Results compare both the steady-state and the transient responses. As a quantitative performance measure, the H2 norm, which is related to the area under the frequency response function, is calculated and compared for both the metastructure and the baseline structure. These results show that it is possible to obtain a favorable vibration response without adding additional mass to the structure. Additionally, the performance measure is utilized to optimize the geometry of the structure, determine the optimal ratio of mass in the absorber to mass of the host structure, and determine the frequencies of the absorbers. The dynamic response of this model is verified using a finite element analysis.
Compact triple band-stop filter using novel epsilon-shaped metamaterial with lumped capacitor
Ali, W. A. E.; Hamdalla, M. Z. M.
2018-04-01
This paper presents the design of a novel epsilon-shaped metamaterial unit cell structure that is applicable for single-band and multi-band applications. A closed-form formulas to control the resonance frequencies of the proposed design are included. The proposed unit cell, which exhibits negative permeability at its frequency bands, is etched from the ground plane to form a band-stop filter. The filter design is constructed to validate the band-notched characteristics of the proposed unit cell. A lumped capacitor is inserted for size reduction purpose in addition to multi-resonance generation. The fundamental resonance frequency is translated from 3.62 GHz to 2.45 GHz, which means that the filter size will be more compact (more than 32% size reduction). The overall size of the proposed filter is 13 × 6 × 1.524 mm3, where the electrical size is 0.221λg × 0.102λg × 0.026λg at the lower frequency band (2.45 GHz). Two other resonance frequencies are generated at 5.3 GHz and 9.2 GHz, which confirm the multi-band behavior of the proposed filter. Good agreement between simulated and measured characteristics of the fabricated filter prototype is achieved.
Drug delivery and formulations.
Breitkreutz, Jörg; Boos, Joachim
2011-01-01
Paediatric drug delivery is a major challenge in drug development. Because of the heterogeneous nature of the patient group, ranging from newborns to adolescents, there is a need to use appropriate excipients, drug dosage forms and delivery devices for different age groups. So far, there is a lack of suitable and safe drug formulations for children, especially for the very young and seriously ill patients. The new EU legislation will enforce paediatric clinical trials and drug development. Current advances in paediatric drug delivery include interesting new concepts such as fast-dissolving drug formulations, including orodispersible tablets and oral thin strips (buccal wafers), and multiparticulate dosage forms based on mini-tabletting or pelletization technologies. Parenteral administration is likely to remain the first choice for children in the neonatal period and for emergency cases. Alternative routes of administration include transdermal, pulmonary and nasal drug delivery systems. A few products are already available on the market, but others still need further investigations and clinical proof of concept.
De-monumentalización de la historia y la ficción en Lumpérica
Fernando Burgos
2013-01-01
The present paper studies Diamela Eltit’s Lumpérica (1983) as an artistic postmodern instance of historical criticism by way of a restitution of all public symbols of protest in a city invaded by fear and silence. This critical attitude towards all kinds of totalitarianism is voiced by the tatterdemalions of the ‘lumpenry’, by a woman with multiple faces, by subversive writing methods, by collective sceneries dismantled by vigilance and terror. The notion of active marginality, and furthermor...
Directory of Open Access Journals (Sweden)
L. E. Whitehouse
2004-01-01
Full Text Available This paper presents a formal method of species lumping that can be applied automatically to intermediate compounds within detailed and complex tropospheric chemical reaction schemes. The method is based on grouping species with reference to their chemical lifetimes and reactivity structures. A method for determining the forward and reverse transformations between individual and lumped compounds is developed. Preliminary application to the Leeds Master Chemical Mechanism (MCMv2.0 has led to the removal of 734 species and 1777 reactions from the scheme, with minimal degradation of accuracy across a wide range of test trajectories relevant to polluted tropospheric conditions. The lumped groups are seen to relate to groups of peroxy acyl nitrates, nitrates, carbonates, oxepins, substituted phenols, oxeacids and peracids with similar lifetimes and reaction rates with OH. In combination with other reduction techniques, such as sensitivity analysis and the application of the quasi-steady state approximation (QSSA, a reduced mechanism has been developed that contains 35% of the number of species and 40% of the number of reactions compared to the full mechanism. This has led to a speed up of a factor of 8 in terms of computer calculation time within box model simulations.
Meng, Luming; Sheong, Fu Kit; Zeng, Xiangze; Zhu, Lizhe; Huang, Xuhui
2017-07-01
Constructing Markov state models from large-scale molecular dynamics simulation trajectories is a promising approach to dissect the kinetic mechanisms of complex chemical and biological processes. Combined with transition path theory, Markov state models can be applied to identify all pathways connecting any conformational states of interest. However, the identified pathways can be too complex to comprehend, especially for multi-body processes where numerous parallel pathways with comparable flux probability often coexist. Here, we have developed a path lumping method to group these parallel pathways into metastable path channels for analysis. We define the similarity between two pathways as the intercrossing flux between them and then apply the spectral clustering algorithm to lump these pathways into groups. We demonstrate the power of our method by applying it to two systems: a 2D-potential consisting of four metastable energy channels and the hydrophobic collapse process of two hydrophobic molecules. In both cases, our algorithm successfully reveals the metastable path channels. We expect this path lumping algorithm to be a promising tool for revealing unprecedented insights into the kinetic mechanisms of complex multi-body processes.
Generalized Kutta–Joukowski theorem for multi-vortex and multi-airfoil flow (a lumped vortex model
Directory of Open Access Journals (Sweden)
Bai Chenyuan
2014-02-01
Full Text Available For purpose of easy identification of the role of free vortices on the lift and drag and for purpose of fast or engineering evaluation of forces for each individual body, we will extend in this paper the Kutta–Joukowski (KJ theorem to the case of inviscid flow with multiple free vortices and multiple airfoils. The major simplification used in this paper is that each airfoil is represented by a lumped vortex, which may hold true when the distances between vortices and bodies are large enough. It is found that the Kutta–Joukowski theorem still holds provided that the local freestream velocity and the circulation of the bound vortex are modified by the induced velocity due to the outside vortices and airfoils. We will demonstrate how to use the present result to identify the role of vortices on the forces according to their position, strength and rotation direction. Moreover, we will apply the present results to a two-cylinder example of Crowdy and the Wagner example to demonstrate how to perform fast force approximation for multi-body and multi-vortex problems. The lumped vortex assumption has the advantage of giving such kinds of approximate results which are very easy to use. The lack of accuracy for such a fast evaluation will be compensated by a rigorous extension, with the lumped vortex assumption removed and with vortex production included, in a forthcoming paper.
airGRteaching: an R-package designed for teaching hydrology with lumped hydrological models
Thirel, Guillaume; Delaigue, Olivier; Coron, Laurent; Andréassian, Vazken; Brigode, Pierre
2017-04-01
Lumped hydrological models are useful and convenient tools for research, engineering and educational purposes. They propose catchment-scale representations of the precipitation-discharge relationship. Thanks to their limited data requirements, they can be easily implemented and run. With such models, it is possible to simulate a number of hydrological key processes over the catchment with limited structural and parametric complexity, typically evapotranspiration, runoff, underground losses, etc. The Hydrology Group at Irstea (Antony) has been developing a suite of rainfall-runoff models over the past 30 years. This resulted in a suite of models running at different time steps (from hourly to annual) applicable for various issues including water balance estimation, forecasting, simulation of impacts and scenario testing. Recently, Irstea has developed an easy-to-use R-package (R Core Team, 2016), called airGR (Coron et al., 2016, 2017), to make these models widely available. Although its initial target public was hydrological modellers, the package is already used for educational purposes. Indeed, simple models allow for rapidly visualising the effects of parameterizations and model components on flows hydrographs. In order to avoid the difficulties that students may have when manipulating R and datasets, we developed (Delaigue and Coron, 2016): - Three simplified functions to prepare data, calibrate a model and run a simulation - Simplified and dynamic plot functions - A shiny (Chang et al., 2016) interface that connects this R-package to a browser-based visualisation tool. On this interface, the students can use different hydrological models (including the possibility to use a snow-accounting model), manually modify their parameters and automatically calibrate their parameters with diverse objective functions. One of the visualisation tabs of the interface includes observed precipitation and temperature, simulated snowpack (if any), observed and simulated
A lumped modeling of river - riparian vegetation interactions with flow variability
Tealdi, S.; Camporeale, C.; Ridolfi, L.
2012-04-01
Flow variability has a great impact on the river morphology and riparian vegetation dynamics. The most common anthropic cause is the dam construction, which often reduces both the discharge regime and sediment transport, thus producing a narrowing and degradation of the river bed. Furthermore, since riparian vegetation is closely connected to discharge stochasticity, it can experience remarkable changes after the construction of artificial reservoirs. A number of field studies have shown the consequences of river regulation on both river morphology and riparian vegetation, which often exhibits significant decreases and shifts along the transect. Riparian vegetation and river morphology are closely linked. Vegetation provides additional resistance to the soil by the root system, and increases the bank slope. Furthermore ,the aggradation/degradation of river bed modifies the probability density function of river water levels, on which the riparian vegetation depends. Therefore, river cross-section and riparian vegetation dynamics are mutually dependent. In this study we propose a simple lumped bio-morphodynamic model that describes the interplay between fluvial cross-section and vegetation dynamics, and the effects of changes in discharge and sediment transport induced by external factors. The model provides the temporal dynamics of the river width and bed elevation. These dynamics turn out to be non-trivial and can exhibit non-monotonic behavior, with aggradations/ degradations, and narrowing/widening phenomena. In this study, we compare the results with and without vegetation, and we quantitatively investigate how vegetation influences river morphodynamics. The model has been tested on real rivers using data obtained from field studies. The agreement between the outcomes and the measured field data is satisfactory.
Fluorodeoxyglucose rate constants, lumped constant, and glucose metabolic rate in rabbit heart
International Nuclear Information System (INIS)
Krivokapich, J.; Huang, S.C.; Selin, C.E.; Phelps, M.E.
1987-01-01
The isolated arterial perfused rabbit interventricular septum was used to measure myocardial metabolic rate for glucose (MMRGlc) and rate constants and lumped constant (LC) for the glucose analogue [ 18 F]fluorodeoxyglucose (FDG) using a tracer kinetic model. FDG was delivered by constant infusion during coincidence counting of tissue 18 F radioactivity. The MMRGlc was measured by the Fick method. Control septa were paced at 72 beats/min and perfused at 1.5 ml/min with oxygenated perfusate containing 5.6 mM glucose and 5 mU/ml insulin. The following conditions were tested: 3.0 and 4.5 ml/min; insulin increased to 25 mU/ml; insulin omitted; 2.8 mM and 11.2 mM glucose; 144 beats/min and 96 paired stimuli/min; and anoxia. Under all conditions studied the phosphorylation (hexokinase) reaction was rate limiting relative to transport. Compared with control conditions, the phosphorylation rate constant was significantly increased with 2.8 mM glucose as well as in anoxia. With 4.5 ml/min and 11.2 mM glucose, conditions that should increase glucose flux into tissue without increasing demand, the phosphorylation rate constant decreased significantly. With 11.2 mM glucose, 96 paired stimuli/min, and anoxia without insulin, a significant increase in the hydrolysis rate of FDG 6-phosphate was observed and suggests that hydrolysis is also an important mechanism for regulating the MMRGlc. Increased transport rate constants were observed with increased flow rates, 96 paired stimuli/min, and anoxia at 96 beats/min. The LC was not significantly different from control in 11 of 14 conditions studied. Therefore, under most conditions in average LC can be used to calculate MMRGlc estimates
Use of Ventricular Assist Device in Univentricular Physiology: The Role of Lumped Parameter Models.
Di Molfetta, Arianna; Ferrari, Gianfranco; Filippelli, Sergio; Fresiello, Libera; Iacobelli, Roberta; Gagliardi, Maria G; Amodeo, Antonio
2016-05-01
Failing single-ventricle (SV) patients might benefit from ventricular assist devices (VADs) as a bridge to heart transplantation. Considering the complex physiopathology of SV patients and the lack of established experience, the aim of this work was to realize and test a lumped parameter model of the cardiovascular system, able to simulate SV hemodynamics and VAD implantation effects. Data of 30 SV patients (10 Norwood, 10 Glenn, and 10 Fontan) were retrospectively collected and used to simulate patients' baseline. Then, the effects of VAD implantation were simulated. Additionally, both the effects of ventricular assistance and cavopulmonary assistance were simulated in different pathologic conditions on Fontan patients, including systolic dysfunction, diastolic dysfunction, and pulmonary vascular resistance increment. The model can reproduce patients' baseline well. Simulation results suggest that the implantation of VAD: (i) increases the cardiac output (CO) in all the three palliation conditions (Norwood 77.2%, Glenn 38.6%, and Fontan 17.2%); (ii) decreases the SV external work (SVEW) (Norwood 55%, Glenn 35.6%, and Fontan 41%); (iii) increases the mean pulmonary arterial pressure (Pap) (Norwood 39.7%, Glenn 12.1%, and Fontan 3%). In Fontan circulation, with systolic dysfunction, the left VAD (LVAD) increases CO (35%), while the right VAD (RVAD) determines a decrement of inferior vena cava pressure (Pvci) (39%) with 34% increment of CO. With diastolic dysfunction, the LVAD increases CO (42%) and the RVAD decreases the Pvci. With pulmonary vascular resistance increment, the RVAD allows the highest CO (50%) increment with the highest decrement of Pvci (53%). The single ventricular external work (SVEW) increases (decreases) increasing the VAD speed in cavopulmonary (ventricular) assistance. Numeric models could be helpful in this challenging and innovative field to support patients and VAD selection to optimize the clinical outcome and personalize the therapy
Ellison, Christopher A.; Groten, Joel T.; Lorenz, David L.; Koller, Karl S.
2016-10-27
Consistent and reliable sediment data are needed by Federal, State, and local government agencies responsible for monitoring water quality, planning river restoration, quantifying sediment budgets, and evaluating the effectiveness of sediment reduction strategies. Heightened concerns about excessive sediment in rivers and the challenge to reduce costs and eliminate data gaps has guided Federal and State interests in pursuing alternative methods for measuring suspended and bedload sediment. Simple and dependable data collection and estimation techniques are needed to generate hydraulic and water-quality information for areas where data are unavailable or difficult to collect.The U.S. Geological Survey, in cooperation with the Minnesota Pollution Control Agency and the Minnesota Department of Natural Resources, completed a study to evaluate the use of dimensionless sediment rating curves (DSRCs) to accurately predict suspended-sediment concentrations (SSCs), bedload, and annual sediment loads for selected rivers and streams in Minnesota based on data collected during 2007 through 2013. This study included the application of DSRC models developed for a small group of streams located in the San Juan River Basin near Pagosa Springs in southwestern Colorado to rivers in Minnesota. Regionally based DSRC models for Minnesota also were developed and compared to DSRC models from Pagosa Springs, Colorado, to evaluate which model provided more accurate predictions of SSCs and bedload in Minnesota.Multiple measures of goodness-of-fit were developed to assess the effectiveness of DSRC models in predicting SSC and bedload for rivers in Minnesota. More than 600 dimensionless ratio values of SSC, bedload, and streamflow were evaluated and delineated according to Pfankuch stream stability categories of “good/fair” and “poor” to develop four Minnesota-based DSRC models. The basis for Pagosa Springs and Minnesota DSRC model effectiveness was founded on measures of goodness
Baseline LAW Glass Formulation Testing
Energy Technology Data Exchange (ETDEWEB)
Kruger, Albert A. [USDOE Office of River Protection, Richland, WA (United States); Mooers, Cavin [The Catholic University of America, Washington, DC (United States). Vitreous State Lab.; Bazemore, Gina [The Catholic University of America, Washington, DC (United States). Vitreous State Lab; Pegg, Ian L. [The Catholic University of America, Washington, DC (United States). Vitreous State Lab; Hight, Kenneth [The Catholic University of America, Washington, DC (United States). Vitreous State Lab; Lai, Shan Tao [The Catholic University of America, Washington, DC (United States). Vitreous State Lab; Buechele, Andrew [The Catholic University of America, Washington, DC (United States). Vitreous State Lab; Rielley, Elizabeth [The Catholic University of America, Washington, DC (United States). Vitreous State Lab; Gan, Hao [The Catholic University of America, Washington, DC (United States). Vitreous State Lab; Muller, Isabelle S. [The Catholic University of America, Washington, DC (United States). Vitreous State Lab; Cecil, Richard [The Catholic University of America, Washington, DC (United States). Vitreous State Lab
2013-06-13
The major objective of the baseline glass formulation work was to develop and select glass formulations that are compliant with contractual and processing requirements for each of the LAW waste streams. Other objectives of the work included preparation and characterization of glasses with respect to the properties of interest, optimization of sulfate loading in the glasses, evaluation of ability to achieve waste loading limits, testing to demonstrate compatibility of glass melts with melter materials of construction, development of glass formulations to support ILAW qualification activities, and identification of glass formulation issues with respect to contract specifications and processing requirements.
Saltstone Clean Cap Formulation
Energy Technology Data Exchange (ETDEWEB)
Langton, C
2005-04-22
The current operation strategy for using Saltstone Vault 4 to receive 0.2 Ci/gallon salt solution waste involves pouring a clean grout layer over the radioactive grout prior to initiating pour into another cell. This will minimize the radiating surface area and reduce the dose rate at the vault and surrounding area. The Clean Cap will be used to shield about four feet of Saltstone poured into a Z-Area vault cell prior to moving to another cell. The minimum thickness of the Clean Cap layer will be determined by the cesium concentration and resulting dose levels and it is expected to be about one foot thick based on current calculations for 0.1 Ci Saltstone that is produced in the Saltstone process by stabilization of 0.2 Ci salt solution. This report documents experiments performed to identify a formulation for the Clean Cap. Thermal transient calculations, adiabatic temperature rise measurements, pour height, time between pour calculations and shielding calculations were beyond the scope and time limitations of this study. However, data required for shielding calculations (composition and specific gravity) are provided for shielding calculations. The approach used to design a Clean Cap formulation was to produce a slurry from the reference premix (10/45/45 weight percent cement/slag/fly ash) and domestic water that resembled as closely as possible the properties of the Saltstone slurry. In addition, options were investigated that may offer advantages such as less bleed water and less heat generation. The options with less bleed water required addition of dispersants. The options with lower heat contained more fly ash and less slag. A mix containing 10/45/45 weight percent cement/slag/fly ash with a water to premix ratio of 0.60 is recommended for the Clean Cap. Although this mix may generate more than 3 volume percent standing water (bleed water), it has rheological, mixing and flow properties that are similar to previously processed Saltstone. The recommended
Saltstone Clean Cap Formulation
International Nuclear Information System (INIS)
Langton, C
2005-01-01
The current operation strategy for using Saltstone Vault 4 to receive 0.2 Ci/gallon salt solution waste involves pouring a clean grout layer over the radioactive grout prior to initiating pour into another cell. This will minimize the radiating surface area and reduce the dose rate at the vault and surrounding area. The Clean Cap will be used to shield about four feet of Saltstone poured into a Z-Area vault cell prior to moving to another cell. The minimum thickness of the Clean Cap layer will be determined by the cesium concentration and resulting dose levels and it is expected to be about one foot thick based on current calculations for 0.1 Ci Saltstone that is produced in the Saltstone process by stabilization of 0.2 Ci salt solution. This report documents experiments performed to identify a formulation for the Clean Cap. Thermal transient calculations, adiabatic temperature rise measurements, pour height, time between pour calculations and shielding calculations were beyond the scope and time limitations of this study. However, data required for shielding calculations (composition and specific gravity) are provided for shielding calculations. The approach used to design a Clean Cap formulation was to produce a slurry from the reference premix (10/45/45 weight percent cement/slag/fly ash) and domestic water that resembled as closely as possible the properties of the Saltstone slurry. In addition, options were investigated that may offer advantages such as less bleed water and less heat generation. The options with less bleed water required addition of dispersants. The options with lower heat contained more fly ash and less slag. A mix containing 10/45/45 weight percent cement/slag/fly ash with a water to premix ratio of 0.60 is recommended for the Clean Cap. Although this mix may generate more than 3 volume percent standing water (bleed water), it has rheological, mixing and flow properties that are similar to previously processed Saltstone. The recommended
Directory of Open Access Journals (Sweden)
Andrea Lauková
2014-08-01
Full Text Available Cow lump cheese represents a traditional Slovak cheese. It belongs to fresh types of cheeses. The aim of this study was to test surviving of commercial probiotic strain Lactobacillus rhamnosus GG in cow lump cheese experimentally infected with L. innocua; (listeriae are contaminants and to check the suitability of GG strain as additive for this product. The counts of GG strain in cow lump cheeses were well balanced during whole experiment. It was found in the counts from 5.48 ± 0.15 to 7.77 ±1.50 log10 cfu/g. Its maximum in cheese was 7.77 ± 1.30 log10 cfu/g on day 7 with stability up to day 14. The identity of GG strain isolated from cheeses was confirmed by PCR. The counts of other lactic acid bacteria were also well balanced during the whole experiment in the experimental cheeses with stability up to day 14. Only in E1/GG cheese, the highest number of LAB was detected (10.60 ±1.26 log10 cfu/g. The count of L. innocua LMG 13568 was not influenced. The pH and lactic acid values were not negatively influenced. Visually, the GG cheese provided a good structure (consistency.It can be disputed that shelf-life of the product could be maintained by this way and/or the product itself with GG strain can be consumed as afunctional food or to serve as a probiotic strain carrier.
Zhou, Shiyu; Wu, Hsin-Ta; Sadeghipour, Khosrov; Scarcella, Carmelo; Eason, Cormac; Rensing, Marc; Power, Mark J; Antony, Cleitus; O'Brien, Peter; Townsend, Paul D; Ossieur, Peter
2017-02-20
We demonstrate how to optimize the performance of PAM-4 transmitters based on lumped Silicon Photonic Mach-Zehnder Modulators (MZMs) for short-reach optical links. Firstly, we analyze the trade-off that occurs between extinction ratio and modulation loss when driving an MZM with a voltage swing less than the MZM's Vπ. This is important when driver circuits are realized in deep submicron CMOS process nodes. Next, a driving scheme based upon a switched capacitor approach is proposed to maximize the achievable bandwidth of the combined lumped MZM and CMOS driver chip. This scheme allows the use of lumped MZM for high speed optical links with reduced RF driver power consumption compared to the conventional approach of driving MZMs (with transmission line based electrodes) with a power amplifier. This is critical for upcoming short-reach link standards such as 400Gb/s 802.3 Ethernet. The driver chip was fabricated using a 65nm CMOS technology and flip-chipped on top of the Silicon Photonic chip (fabricated using IMEC's ISIPP25G technology) that contains the MZM. Open eyes with 4dB extinction ratio for a 36Gb/s (18Gbaud) PAM-4 signal are experimentally demonstrated. The electronic driver chip has a core area of only 0.11mm2 and consumes 236mW from 1.2V and 2.4V supply voltages. This corresponds to an energy efficiency of 6.55pJ/bit including Gray encoder and retiming, or 5.37pJ/bit for the driver circuit only.
De-monumentalización de la historia y la ficción en Lumpérica
Directory of Open Access Journals (Sweden)
Fernando Burgos
2013-07-01
Full Text Available The present paper studies Diamela Eltit’s Lumpérica (1983 as an artistic postmodern instance of historical criticism by way of a restitution of all public symbols of protest in a city invaded by fear and silence. This critical attitude towards all kinds of totalitarianism is voiced by the tatterdemalions of the ‘lumpenry’, by a woman with multiple faces, by subversive writing methods, by collective sceneries dismantled by vigilance and terror. The notion of active marginality, and furthermore, the notion of marginality triggers the creation of a neo-vanguard writing that radically alters the principles of novel-writing.
$q\\overline{q}$ interaction in light-cone gauge formulations of Yang-Mills theory in 1+1 dimensions
Bassetto, A.; Nardelli, G.
1997-01-01
A rectangular Wilson loop with sides parallel to space and time directions is perturbatively evaluated in two light-cone gauge formulations of Yang-Mills theory in 1+1 dimensions, with ``instantaneous'' and ``causal'' interactions between static quarks. In the instantaneous formulation we get Abelian-like exponentiation of the area in terms of $C_F$. In the ``causal'' formulation the loop depends not only on the area, but also on the dimensionless ratio $\\beta = {L \\over T}$, $2L$ and $2T$ being the lengths of the rectangular sides. Besides it also exhibits dependence on $C_A$. In the limit $T \\to \\infty$ the area law is recovered, but dependence on $C_A$ survives. Consequences of these results are pointed out.
Novel Formulations for Antimicrobial Peptides
Directory of Open Access Journals (Sweden)
Ana Maria Carmona-Ribeiro
2014-10-01
Full Text Available Peptides in general hold much promise as a major ingredient in novel supramolecular assemblies. They may become essential in vaccine design, antimicrobial chemotherapy, cancer immunotherapy, food preservation, organs transplants, design of novel materials for dentistry, formulations against diabetes and other important strategical applications. This review discusses how novel formulations may improve the therapeutic index of antimicrobial peptides by protecting their activity and improving their bioavailability. The diversity of novel formulations using lipids, liposomes, nanoparticles, polymers, micelles, etc., within the limits of nanotechnology may also provide novel applications going beyond antimicrobial chemotherapy.
Yang, Xiuqing; Chen, Yanmei; Wu, Ruiwei; Nie, Zhiqiang; Han, Zuoying; Tan, Kaili; Chen, Linyong
2018-04-01
Pilot-scale fermentation is one of the important processes for achieving industrialization of biogenic coalbed methane (CBM), although the mechanism of biogenic CBM remains unknown. In this study, 16 samples of formation water from CBM production wells were collected and enriched for methane production, and the methane content was between 3.1 and 21.4%. The formation water of maximum methane production was used as inoculum source for pilot-scale fermentation. The maximum methane yield of the pilot-scale fermentation with lump anthracite amendment reached 13.66 μmol CH 4 /mL, suggesting that indigenous microorganisms from formation water degraded coal to produce methane. Illumina high-throughput sequencing analysis revealed that the bacterial and archaeal communities in the formation water sample differed greatly from the methanogic water enrichment culture. The hydrogenotrophic methanogen Methanocalculus dominated the formation water. Acetoclastic methanogens, from the order Methanosarcinales, dominated coal bioconversion. Thus, the biogenic methanogenic pathway ex situ cannot be simply identified according to methanogenic archaea in the original inoculum. Importantly, this study was the first time to successfully simulate methanogenesis in large-capacity fermentors (160 L) with lump anthracite amendment, and the result was also a realistic case for methane generation in pilot-scale ex situ.
Directory of Open Access Journals (Sweden)
Shane Stimpson
2017-09-01
Full Text Available An essential component of the neutron transport solver is the resonance self-shielding calculation used to determine equivalence cross sections. The neutron transport code, MPACT, is currently using the subgroup self-shielding method, in which the method of characteristics (MOC is used to solve purely absorbing fixed-source problems. Recent efforts incorporating multigroup kernels to the MOC solvers in MPACT have reduced runtime by roughly 2×. Applying the same concepts for self-shielding and developing a novel lumped parameter approach to MOC, substantial improvements have also been made to the self-shielding computational efficiency without sacrificing any accuracy. These new multigroup and lumped parameter capabilities have been demonstrated on two test cases: (1 a single lattice with quarter symmetry known as VERA (Virtual Environment for Reactor Applications Progression Problem 2a and (2 a two-dimensional quarter-core slice known as Problem 5a-2D. From these cases, self-shielding computational time was reduced by roughly 3–4×, with a corresponding 15–20% increase in overall memory burden. An azimuthal angle sensitivity study also shows that only half as many angles are needed, yielding an additional speedup of 2×. In total, the improvements yield roughly a 7–8× speedup. Given these performance benefits, these approaches have been adopted as the default in MPACT.
International Nuclear Information System (INIS)
Stimpson, Shane G.; Liu, Yuxuan; Collins, Benjamin S.; Clarno, Kevin T.
2017-01-01
An essential component of the neutron transport solver is the resonance self-shielding calculation used to determine equivalence cross sections. The neutron transport code, MPACT, is currently using the subgroup self-shielding method, in which the method of characteristics (MOC) is used to solve purely absorbing fixed-source problems. Recent efforts incorporating multigroup kernels to the MOC solvers in MPACT have reduced runtime by roughly 2×. Applying the same concepts for self-shielding and developing a novel lumped parameter approach to MOC, substantial improvements have also been made to the self-shielding computational efficiency without sacrificing any accuracy. These new multigroup and lumped parameter capabilities have been demonstrated on two test cases: (1) a single lattice with quarter symmetry known as VERA (Virtual Environment for Reactor Applications) Progression Problem 2a and (2) a two-dimensional quarter-core slice known as Problem 5a-2D. From these cases, self-shielding computational time was reduced by roughly 3–4×, with a corresponding 15–20% increase in overall memory burden. An azimuthal angle sensitivity study also shows that only half as many angles are needed, yielding an additional speedup of 2×. In total, the improvements yield roughly a 7–8× speedup. Furthermore given these performance benefits, these approaches have been adopted as the default in MPACT.
Soltani Bozchalooi, Iman; Liang, Ming
2018-04-01
A discussion paper entitled "On the distribution of the modulus of Gabor wavelet coefficients and the upper bound of the dimensionless smoothness index in the case of additive Gaussian noises: revisited" by Dong Wang, Qiang Zhou, Kwok-Leung Tsui has been brought to our attention recently. This discussion paper (hereafter called Wang et al. paper) is based on arguments that are fundamentally incorrect and which we rebut within this commentary. However, as the flaws in the arguments proposed by Wang et al. are clear, we will keep this rebuttal as brief as possible.
Energy Technology Data Exchange (ETDEWEB)
Bracamonte-Baran, Johane Hans; Baritto-Loreto, Miguel Leonardo [Universidad Central de Venezuela (Venezuela)]. E-mails: johanehb@gmail.com; johane.bracamonte@ucv.ve; miguel.baritto@ucv.ve
2013-04-15
The dimensionless model developed and validated by Baritto and Bracamonte (2012) for the thermal behavior of flat plate solar collector without glass cover is improved by adding the entropy balance equation in a dimensionless form. The model is solved for a wide range of aspect ratios and mass flow numbers. A parametric study is developed and the distribution of internal irreversibilities along the collector is analyzed. The influence of the design parameters on the entropy generation by fluid friction and heat transfer is analyzed and it is found that for certain combinations of these parameters optimal thermodynamic operation can be achieved. [Spanish] En el presente trabajo, el modelo adimensional desarrollado y validado por Baritto y Bracamonte (2012) para describir el comportamiento termico de colectores solares de placas planas sin cubierta transparente, se complementa con la ecuacion adimensional de balance de entropia para un elemento diferencial de colector solar. El modelo se resuelve para un amplio rango de valores de relaciones de aspecto y numero de flujo de masa. A partir de los resultados del modelo se desarrolla un analisis detallado de la influencia de estos parametros sobre la distribucion de irreversibilidades internas a lo largo del colector. Adicionalmente se estudia la influencia de estos parametros sobre los numeros de generacion de entropia por friccion viscosa, por transferencia de calor y total. Se encuentra que existen combinaciones de los parametros antes mencionados, para los cuales, la operacion del colector es termodinamicamente optima para numeros de flujo de masa elevados.
Tactile friction of topical formulations.
Skedung, L; Buraczewska-Norin, I; Dawood, N; Rutland, M W; Ringstad, L
2016-02-01
The tactile perception is essential for all types of topical formulations (cosmetic, pharmaceutical, medical device) and the possibility to predict the sensorial response by using instrumental methods instead of sensory testing would save time and cost at an early stage product development. Here, we report on an instrumental evaluation method using tactile friction measurements to estimate perceptual attributes of topical formulations. Friction was measured between an index finger and an artificial skin substrate after application of formulations using a force sensor. Both model formulations of liquid crystalline phase structures with significantly different tactile properties, as well as commercial pharmaceutical moisturizing creams being more tactile-similar, were investigated. Friction coefficients were calculated as the ratio of the friction force to the applied load. The structures of the model formulations and phase transitions as a result of water evaporation were identified using optical microscopy. The friction device could distinguish friction coefficients between the phase structures, as well as the commercial creams after spreading and absorption into the substrate. In addition, phase transitions resulting in alterations in the feel of the formulations could be detected. A correlation was established between skin hydration and friction coefficient, where hydrated skin gave rise to higher friction. Also a link between skin smoothening and finger friction was established for the commercial moisturizing creams, although further investigations are needed to analyse this and correlations with other sensorial attributes in more detail. The present investigation shows that tactile friction measurements have potential as an alternative or complement in the evaluation of perception of topical formulations. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Alvarez-Garreton, C.; Ryu, D.; Western, A. W.; Su, C.-H.; Crow, W. T.; Robertson, D. E.; Leahy, C.
2015-04-01
Assimilation of remotely sensed soil moisture data (SM-DA) to correct soil water stores of rainfall-runoff models has shown skill in improving streamflow prediction. In the case of large and sparsely monitored catchments, SM-DA is a particularly attractive tool. Within this context, we assimilate satellite soil moisture (SM) retrievals from the Advanced Microwave Scanning Radiometer (AMSR-E), the Advanced Scatterometer (ASCAT) and the Soil Moisture and Ocean Salinity (SMOS) instrument, using an Ensemble Kalman filter to improve operational flood prediction within a large (> 40 000 km2) semi-arid catchment in Australia. We assess the importance of accounting for channel routing and the spatial distribution of forcing data by applying SM-DA to a lumped and a semi-distributed scheme of the probability distributed model (PDM). Our scheme also accounts for model error representation by explicitly correcting bias in soil moisture and streamflow in the ensemble generation process, and for seasonal biases and errors in the satellite data. Before assimilation, the semi-distributed model provided a more accurate streamflow prediction (Nash-Sutcliffe efficiency, NSE = 0.77) than the lumped model (NSE = 0.67) at the catchment outlet. However, this did not ensure good performance at the "ungauged" inner catchments (two of them with NSE below 0.3). After SM-DA, the streamflow ensemble prediction at the outlet was improved in both the lumped and the semi-distributed schemes: the root mean square error of the ensemble was reduced by 22 and 24%, respectively; the false alarm ratio was reduced by 9% in both cases; the peak volume error was reduced by 58 and 1%, respectively; the ensemble skill was improved (evidenced by 12 and 13% reductions in the continuous ranked probability scores, respectively); and the ensemble reliability was increased in both cases (expressed by flatter rank histograms). SM-DA did not improve NSE. Our findings imply that even when rainfall is the main driver
International Nuclear Information System (INIS)
Abbas, H.; Imran, S.; Waris, Noorul-ain-Hafeez; Khanam, A.; Khurshid, R.
2010-01-01
Background: The spectrum of breast lesions in adolescents varies markedly from that for adults, with the former lesions being overwhelmingly benign. Fine needle biopsy can be used to distinguish benign and malignant tumour. Study Design: This study examined the characteristics and outcome of women with different age groups in whom physical examination was their sole method of lump in breast detection. Patients and Methods: A total of 200 patients were included in the study. These were divided into 3 groups. Group A was consisting of 75 girls with age of pubescent. Group B included 69 suspected breast cancer women with age range 26-38 years. Fifty-six suspected breast cancer women with age range 41-60 year were included as group C. Study was carried out in patients admitted in the Department/Out-door of Surgery, Sir Ganga Ram Hospital, Lahore, Pakistan. Study period was 6 months. All women received a physical examination by a breast surgeon. Proforma including demographic and clinical characteristics were filled. The diagnosis for patients in this study was achieved by core needle biopsy using a 14-gauge cutting needle. Results: It was observed that early age at menarche ( 25 may be a risk factor in peri/post menopausal women. Active life style is more important with increasing age as it decreases the risk of developing tumour state. Family history was more common in women with peri/post menopausal status as compared to other age groups. Clinical characteristics showed that lump size <2.5 cm was more common in both pubescent and reproductive age. While lump size with a range of 2.5-5.0 cm, was observed in all groups of patients. Fibroadenoma is observed in almost all women with pubescent age while both benign and malignant tumour observed in women with reproductive age. Malignant tumour was observed mostly in women with peri/post menopausal status. Conclusion: Study concluded that early detection or clinical examination with FNA cut out the patients from harassment
airGR: a suite of lumped hydrological models in an R-package
Coron, Laurent; Perrin, Charles; Delaigue, Olivier; Andréassian, Vazken; Thirel, Guillaume
2016-04-01
Lumped hydrological models are useful and convenient tools for research, engineering and educational purposes. They propose catchment-scale representations of the precipitation-discharge relationship. Thanks to their limited data requirements, they can be easily implemented and run. With such models, it is possible to simulate a number of hydrological key processes over the catchment with limited structural and parametric complexity, typically evapotranspiration, runoff, underground losses, etc. The Hydrology Group at Irstea (Antony) has been developing a suite of rainfall-runoff models over the past 30 years with the main objectives of designing models as efficient as possible in terms of streamflow simulation, applicable to a wide range of catchments and having low data requirements. This resulted in a suite of models running at different time steps (from hourly to annual) applicable for various issues including water balance estimation, forecasting, simulation of impacts and scenario testing. Recently, Irstea has developed an easy-to-use R-package (R Core Team, 2015), called airGR, to make these models widely available. It includes: - the water balance annual GR1A (Mouehli et al., 2006), - the monthly GR2M (Mouehli, 2003) models, - three versions of the daily model, namely GR4J (Perrin et al., 2003), GR5J (Le Moine, 2008) and GR6J (Pushpalatha et al., 2011), - the hourly GR4H model (Mathevet, 2005), - a degree-day snow module CemaNeige (Valéry et al., 2014). The airGR package has been designed to facilitate the use by non-expert users and allow the addition of evaluation criteria, models or calibration algorithms selected by the end-user. Each model core is coded in FORTRAN to ensure low computational time. The other package functions (i.e. mainly the calibration algorithm and the efficiency criteria) are coded in R. The package is already used for educational purposes. The presentation will detail the main functionalities of the package and present a case
Abuse-deterrent Opioid Formulations.
Litman, Ronald S; Pagán, Olivia H; Cicero, Theodore J
2017-12-18
Abuse-deterrent opioid formulations have been suggested as one way to decrease the abuse, addiction, and overdose of orally prescribed opioids. Ten oral opioid formulations have received abuse-deterrent labeling by the U.S. Food and Drug Administration (FDA). Their properties consist of physical and/or chemical means by which the pills resist manipulation and create a barrier to unintended administration, such as chewing, nasal snorting, smoking, and intravenous injection. In this review, we describe the mechanisms of abuse-deterrent technology, the types of premarketing studies required for FDA approval, the pharmacology of the currently approved abuse-deterrent opioid formulations, and the evidence for and against their influence on opioid abuse. We conclude that there is currently insufficient evidence to indicate that the availability of abuse-deterrent opioid formulations has altered the trajectory of opioid overdose and addiction; however, postmarketing studies are in their infancy, and novel deterrent formulations are continually being developed and submitted for marketing approval.
3D lumped components and miniaturized bandpass filter in an ultra-thin M-LCP for SOP applications
Arabi, Eyad A.
2013-01-01
In this work, a library of 3D lumped components completely embedded in the thinnest, multilayer LCP (M-LCP) stack- up with four metallization layers and 100 μm of total thickness, is reported for the first time. A vertically and horizontally interdigitated capacitor, realized in this stack-up, provides higher self resonant frequency as compared to a similarly sized conventional parallel plate capacitor. Based on the above mentioned library, a miniaturized bandpass filter is presented for the GPS application. It utilizes mutually coupled inductors and is the smallest reported in the literature with a size of (0.035×0.028×0.00089)λg. Finally, the same filter realized in a competing ceramic technology (LTCC) is compared in performance with the ultra-thin M-LCP design. The M-LCP module presented in this work is inherently exible and offers great potential for wearable and conformal applications.
Deng, De-Ming; Chang, Cheng-Hung
2015-05-14
Conventional studies of biomolecular behaviors rely largely on the construction of kinetic schemes. Since the selection of these networks is not unique, a concern is raised whether and under which conditions hierarchical schemes can reveal the same experimentally measured fluctuating behaviors and unique fluctuation related physical properties. To clarify these questions, we introduce stochasticity into the traditional lumping analysis, generalize it from rate equations to chemical master equations and stochastic differential equations, and extract the fluctuation relations between kinetically and thermodynamically equivalent networks under intrinsic and extrinsic noises. The results provide a theoretical basis for the legitimate use of low-dimensional models in the studies of macromolecular fluctuations and, more generally, for exploring stochastic features in different levels of contracted networks in chemical and biological kinetic systems.
Deng, De-Ming; Chang, Cheng-Hung
2015-05-01
Conventional studies of biomolecular behaviors rely largely on the construction of kinetic schemes. Since the selection of these networks is not unique, a concern is raised whether and under which conditions hierarchical schemes can reveal the same experimentally measured fluctuating behaviors and unique fluctuation related physical properties. To clarify these questions, we introduce stochasticity into the traditional lumping analysis, generalize it from rate equations to chemical master equations and stochastic differential equations, and extract the fluctuation relations between kinetically and thermodynamically equivalent networks under intrinsic and extrinsic noises. The results provide a theoretical basis for the legitimate use of low-dimensional models in the studies of macromolecular fluctuations and, more generally, for exploring stochastic features in different levels of contracted networks in chemical and biological kinetic systems.
De-monumentalización de la historia y la ficción en Lumpérica
Burgos, Fernando; The University of Memphis
2013-01-01
Este ensayo postula un estudio de Lumpérica (1983) de Diamela Eltit como una manifestación artística posmoderna de crítica a la Historia a través de una restitución de todas las grafías públicas de protesta en una ciudad invadida por el miedo y el mutismo. Esa función crítica hacia todo tipo de totalitarismo recae en los desarrapados del lumperío, en una mujer de múltiples rostros, en modos subversivos de la escritura, en escenarios colectivos desmantelados por la vigilancia y el terror. La n...
A 3D Lumped Thermal Network Model for Long-term Load Profiles Analysis in High Power IGBT Modules
DEFF Research Database (Denmark)
Bahman, Amir Sajjad; Ma, Ke; Ghimire, Pramod
2016-01-01
The conventional RC lumped thermal networks are widely used to estimate the temperature of power devices, but they are lack of accuracy in addressing detailed thermal behaviors/couplings in different locations and layers of the high power IGBT modules. On the other hand, Finite Element (FE......)-based simulation is another method which is often used to analyze the steady-state thermal distribution of IGBT modules, but it is not possible to be used for long-term analysis of load profiles of power converter, which is needed for reliability assessments and better thermal design. This paper proposes a novel...... enables both accurate and fast temperature estimation of high power IGBT modules in the real loading conditions of the converter; meanwhile the critical details of the thermal dynamics and thermal distribution are also maintained. The proposed thermal model is verified by both FEM simulation...
Formulations of Amlodipine: A Review
Directory of Open Access Journals (Sweden)
Muhammad Ali Sheraz
2016-01-01
Full Text Available Amlodipine (AD is a calcium channel blocker that is mainly used in the treatment of hypertension and angina. However, latest findings have revealed that its efficacy is not only limited to the treatment of cardiovascular diseases as it has shown to possess antioxidant activity and plays an important role in apoptosis. Therefore, it is also employed in the treatment of cerebrovascular stroke, neurodegenerative diseases, leukemia, breast cancer, and so forth either alone or in combination with other drugs. AD is a photosensitive drug and requires protection from light. A number of workers have tried to formulate various conventional and nonconventional dosage forms of AD. This review highlights all the formulations that have been developed to achieve maximum stability with the desired therapeutic action for the delivery of AD such as fast dissolving tablets, floating tablets, layered tablets, single-pill combinations, capsules, oral and transdermal films, suspensions, emulsions, mucoadhesive microspheres, gels, transdermal patches, and liposomal formulations.
Woodward, Simon James Roy; Wöhling, Thomas; Rode, Michael; Stenger, Roland
2017-09-01
The common practice of infrequent (e.g., monthly) stream water quality sampling for state of the environment monitoring may, when combined with high resolution stream flow data, provide sufficient information to accurately characterise the dominant nutrient transfer pathways and predict annual catchment yields. In the proposed approach, we use the spatially lumped catchment model StreamGEM to predict daily stream flow and nitrate concentration (mg L-1 NO3-N) in four contrasting mesoscale headwater catchments based on four years of daily rainfall, potential evapotranspiration, and stream flow measurements, and monthly or daily nitrate concentrations. Posterior model parameter distributions were estimated using the Markov Chain Monte Carlo sampling code DREAMZS and a log-likelihood function assuming heteroscedastic, t-distributed residuals. Despite high uncertainty in some model parameters, the flow and nitrate calibration data was well reproduced across all catchments (Nash-Sutcliffe efficiency against Log transformed data, NSL, in the range 0.62-0.83 for daily flow and 0.17-0.88 for nitrate concentration). The slight increase in the size of the residuals for a separate validation period was considered acceptable (NSL in the range 0.60-0.89 for daily flow and 0.10-0.74 for nitrate concentration, excluding one data set with limited validation data). Proportions of flow and nitrate discharge attributed to near-surface, fast seasonal groundwater and slow deeper groundwater were consistent with expectations based on catchment geology. The results for the Weida Stream in Thuringia, Germany, using monthly as opposed to daily nitrate data were, for all intents and purposes, identical, suggesting that four years of monthly nitrate sampling provides sufficient information for calibration of the StreamGEM model and prediction of catchment dynamics. This study highlights the remarkable effectiveness of process based, spatially lumped modelling with commonly available monthly
Abbas, Hafsa; Imran, Saira; Waris, Noorul-ain-Hafeez; Khanam, Andleeb; Khurshid, Rukshshan
2010-01-01
The spectrum of breast lesions in adolescents varies markedly from that for adults, with the former lesions being overwhelmingly benign. Fine needle biopsy can be used to distinguish benign and malignant tumour. This study examined the characteristics and outcome of women with different age groups in whom physical examination was their sole method of lump in breast detection. A total of 200 patients were included in the study. These were divided into 3 groups. Group A was consisting of 75 girls with age of pubescent. Group B included 69 suspected breast cancer women with age range 26-38 years. Fifty-six suspected breast cancer women with age range 41-60 year were included as group C. Study was carried out in patients admitted in the Department/Out-door of Surgery, Sir Ganga Ram Hospital, Lahore, Pakistan. Study period was 6 months. All women received a physical examination by a breast surgeon. Proforma including demographic and clinical characteristics were filled. The diagnosis for patients in this study was achieved by core needle biopsy using a 14-gauge cutting needle. It was observed that early age at menarche (25 may be a risk factor in peri/post menopausal women. Active life style is more important with increasing age as it decreases the risk of developing tumour state. Family history was more common in women with peri/post menopausal status as compared to other age groups. Clinical characteristics showed that lump size early detection or clinical examination with FNA cut out the patients from harassment of malignancy and complications especially in the pubescent age. It is also found that Physical examination remain the useful indicators of prognosis in diagnosing cancer. Further research is needed to fully understand the reasons for variations in breast disease outcomes i.e. malignant or benign.
Jurgens, Bryant; Böhlke, John Karl; Kauffman, Leon J.; Belitz, Kenneth; Esser, Bradley K.
2016-01-01
A partial exponential lumped parameter model (PEM) was derived to determine age distributions and nitrate trends in long-screened production wells. The PEM can simulate age distributions for wells screened over any finite interval of an aquifer that has an exponential distribution of age with depth. The PEM has 3 parameters – the ratio of saturated thickness to the top and bottom of the screen and mean age, but these can be reduced to 1 parameter (mean age) by using well construction information and estimates of the saturated thickness. The PEM was tested with data from 30 production wells in a heterogeneous alluvial fan aquifer in California, USA. Well construction data were used to guide parameterization of a PEM for each well and mean age was calibrated to measured environmental tracer data (3H, 3He, CFC-113, and 14C). Results were compared to age distributions generated for individual wells using advective particle tracking models (PTMs). Age distributions from PTMs were more complex than PEM distributions, but PEMs provided better fits to tracer data, partly because the PTMs did not simulate 14C accurately in wells that captured varying amounts of old groundwater recharged at lower rates prior to groundwater development and irrigation. Nitrate trends were simulated independently of the calibration process and the PEM provided good fits for at least 11 of 24 wells. This work shows that the PEM, and lumped parameter models (LPMs) in general, can often identify critical features of the age distributions in wells that are needed to explain observed tracer data and nonpoint source contaminant trends, even in systems where aquifer heterogeneity and water-use complicate distributions of age. While accurate PTMs are preferable for understanding and predicting aquifer-scale responses to water use and contaminant transport, LPMs can be sensitive to local conditions near individual wells that may be inaccurately represented or missing in an aquifer-scale flow model.
Smolders, K.; Volckaert, M.; Swevers, J.
2008-11-01
This paper presents a nonlinear model-based iterative learning control procedure to achieve accurate tracking control for nonlinear lumped mechanical continuous-time systems. The model structure used in this iterative learning control procedure is new and combines a linear state space model and a nonlinear feature space transformation. An intuitive two-step iterative algorithm to identify the model parameters is presented. It alternates between the estimation of the linear and the nonlinear model part. It is assumed that besides the input and output signals also the full state vector of the system is available for identification. A measurement and signal processing procedure to estimate these signals for lumped mechanical systems is presented. The iterative learning control procedure relies on the calculation of the input that generates a given model output, so-called offline model inversion. A new offline nonlinear model inversion method for continuous-time, nonlinear time-invariant, state space models based on Newton's method is presented and applied to the new model structure. This model inversion method is not restricted to minimum phase models. It requires only calculation of the first order derivatives of the state space model and is applicable to multivariable models. For periodic reference signals the method yields a compact implementation in the frequency domain. Moreover it is shown that a bandwidth can be specified up to which learning is allowed when using this inversion method in the iterative learning control procedure. Experimental results for a nonlinear single-input-single-output system corresponding to a quarter car on a hydraulic test rig are presented. It is shown that the new nonlinear approach outperforms the linear iterative learning control approach which is currently used in the automotive industry on durability test rigs.
2010-10-01
... 42 Public Health 1 2010-10-01 2010-10-01 false May a Self-Governance Tribe receive statutorily mandated grant funding in an annual lump sum advance payment? 137.65 Section 137.65 Public Health PUBLIC... HUMAN SERVICES TRIBAL SELF-GOVERNANCE Statutorily Mandated Grants § 137.65 May a Self-Governance Tribe...
2010-04-01
... decedents dying after December 31, 1976, and before January 1, 1979. 20.2039-3 Section 20.2039-3 Internal...; ESTATES OF DECEDENTS DYING AFTER AUGUST 16, 1954 Gross Estate § 20.2039-3 Lump sum distributions under “qualified plans;” decedents dying after December 31, 1976, and before January 1, 1979. (a) Limitation of...
2010-04-01
... decedents dying after December 31, 1978. 20.2039-4 Section 20.2039-4 Internal Revenue INTERNAL REVENUE... DYING AFTER AUGUST 16, 1954 Gross Estate § 20.2039-4 Lump sum distributions from “qualified plans;” decedents dying after December 31, 1978. (a) Limitation on section 2039(c) exclusion. This section applies...
Directory of Open Access Journals (Sweden)
Ansari Maulana Mohammed
2009-04-01
Full Text Available Abstract Introduction Intrauterine contraceptive devices may at times perforate and migrate to adjacent organs. Such uterine perforation usually passes unnoticed with development of potentially serious complications. Case presentation A 25-year-old woman of North Indian origin presented with an acute tender lump in the right iliac fossa. The lump was initially thought to be an appendicular lump and treated conservatively. Resolution of the lump was incomplete. On exploratory laparotomy, a hard suspicious mass was found in the anterior abdominal wall of the right iliac fossa. Wide excision and bisection of the mass revealed a copper-T embedded inside. Examination of the uterus did not show any evidence of perforation. The next day, the patient gave a history of past copper-T Intrauterine contraceptive device insertion. Conclusions Copper-T insertion is one of the simplest contraceptive methods but its neglect with inadequate follow-up may lead to uterine perforation and extra-uterine migration. Regular self-examination for the "threads" supplemented with abdominal X-ray and/or ultrasound in the follow-up may detect copper-T migration early. To the best of our knowledge, this is the first report of intrauterine contraceptive device migration to the anterior abdominal wall of the right iliac fossa.
Optimal Compensation with Hidden Action and Lump-Sum Payment in a Continuous-Time Model
International Nuclear Information System (INIS)
Cvitanic, Jaksa; Wan, Xuhu; Zhang Jianfeng
2009-01-01
We consider a problem of finding optimal contracts in continuous time, when the agent's actions are unobservable by the principal, who pays the agent with a one-time payoff at the end of the contract. We fully solve the case of quadratic cost and separable utility, for general utility functions. The optimal contract is, in general, a nonlinear function of the final outcome only, while in the previously solved cases, for exponential and linear utility functions, the optimal contract is linear in the final output value. In a specific example we compute, the first-best principal's utility is infinite, while it becomes finite with hidden action, which is increasing in value of the output. In the second part of the paper we formulate a general mathematical theory for the problem. We apply the stochastic maximum principle to give necessary conditions for optimal contracts. Sufficient conditions are hard to establish, but we suggest a way to check sufficiency using non-convex optimization
Hamiltonian formulation of the supermembrane
International Nuclear Information System (INIS)
Bergshoeff, E.; Sezgin, E.; Tanii, Y.
1987-06-01
The Hamiltonian formulation of the supermembrane theory in eleven dimensions is given. The covariant split of the first and second class constraints is exhibited, and their Dirac brackets are computed. Gauge conditions are imposed in such a way that the reparametrizations of the membrane with divergence free 2-vectors are unfixed. (author). 10 refs
Curcumin nanodisks: formulation and characterization
Ghosh, Mistuni; Singh, Amareshwar T. K.; Xu, Wenwei; Sulchek, Todd; Gordon, Leo I.; Ryan, Robert O.
2010-01-01
Nanodisks (ND) are nanoscale, disk-shaped phospholipid bilayers whose edge is stabilized by apolipoproteins. In the present study, ND were formulated with the bioactive polyphenol, curcumin, at a 6:1 phospholipid:curcumin molar ratio. Atomic force microscopy revealed that curcumin-ND are particles with diameters
Alternate formulations of classical electrodynamics
International Nuclear Information System (INIS)
Beil, R.G.
1975-01-01
The Lorentz--Dirac, Wheeler--Feynman, and Synge formulations of classical electrodynamics are compared with regard to their equations of motion for charged particles and their treatment of radiation. It is found that the less familiar Synge theory offers a viable alternate to the other two, since it is theoretically consistent and predicts results not at variance with experiment
Rogers, Gregory M.; Reinecke, Mark A.; Curry, John F.
2005-01-01
For the Treatment for Adolescents With Depression Study (TADS), a cognitive-behavioral therapy (CBT) manual was developed with the aim of balancing standardization and flexibility. In this article, we describe the manual's case formulation procedures, which served as one major mechanism of flexibility in TADS CBT. We first describe the essential…
Covariant Formulation of Hooke's Law.
Gron, O.
1981-01-01
Introducing a four-vector strain and a four-force stress, Hooke's law is written as a four-vector equation. This formulation is shown to clarify seemingly paradoxical results in connection with uniformly accelerated motion, and rotational motion with angular acceleration. (Author/JN)
On Hamiltonian formulation of cosmologies
Indian Academy of Sciences (India)
This opens up the way to the usual technique of quantization. Elbaz et al [4] have applied this method to the Hamiltonian formulation of FRW cosmological equations. This note presents a generalization of this approach to a variety of cosmologies. A general Schrödinger wave equation has been derived and exact solutions ...
A simple lumped model to convert air temperature into surface water temperature in lakes
Directory of Open Access Journals (Sweden)
S. Piccolroaz
2013-08-01
Full Text Available Water temperature in lakes is governed by a complex heat budget, where the estimation of the single fluxes requires the use of several hydro-meteorological variables that are not generally available. In order to address this issue, we developed Air2Water, a simple physically based model to relate the temperature of the lake superficial layer (epilimnion to air temperature only. The model has the form of an ordinary differential equation that accounts for the overall heat exchanges with the atmosphere and the deeper layer of the lake (hypolimnion by means of simplified relationships, which contain a few parameters (from four to eight in the different proposed formulations to be calibrated with the combined use of air and water temperature measurements. The calibration of the parameters in a given case study allows for one to estimate, in a synthetic way, the influence of the main processes controlling the lake thermal dynamics, and to recognize the atmospheric temperature as the main factor driving the evolution of the system. In fact, under certain hypotheses the air temperature variation implicitly contains proper information about the other major processes involved, and hence in our approach is considered as the only input variable of the model. In particular, the model is suitable to be applied over long timescales (from monthly to interannual, and can be easily used to predict the response of a lake to climate change, since projected air temperatures are usually available by large-scale global circulation models. In this paper, the model is applied to Lake Superior (USA–Canada considering a 27 yr record of measurements, among which 18 yr are used for calibration and the remaining 9 yr for model validation. The calibration of the model is obtained by using the generalized likelihood uncertainty estimation (GLUE methodology, which also allows for a sensitivity analysis of the parameters. The results show remarkable agreement with
Langevin formulation of quantum dynamics
International Nuclear Information System (INIS)
Roncadelli, M.
1989-03-01
We first show that nonrelativistic quantum mechanics formulated at imaginary-(h/2 π) can formally be viewed as the Fokker-Planck description of a frictionless brownian motion, which occurs (in general) in an absorbing medium. We next offer a new formulation of quantum mechanics, which is basically the Langevin treatment of this brownian motion. Explicitly, we derive a noise-average representation for the transition probability W(X'',t''|X',t'), in terms of the solutions to a Langevin equation with a Gaussian white-noise. Upon analytic continuation back to real-(h/2 π),W(X'',t''|X',t') becomes the propagator of the original Schroedinger equation. Our approach allows for a straightforward application to quantum dynamical problems of the mathematical techniques of classical stochastic processes. Moreover, computer simulations of quantum mechanical systems can be carried out by using numerical programs based on the Langevin dynamics. (author). 19 refs, 1 tab
Salgado, F., II; Vélez, J.
2014-12-01
The catchment area is considered as the planning unit of natural resources where multiple factors as biotic, abiotic and human interact in a web of relationships making this unit a complex system. It is also considered by several authors as the most suitable unit for studying the water movement in nature and a tool for the understanding of natural processes. This research implements several hydrological models commonly used in water resources management and planning. It is the case of Témez, abcd, T, P, ARMA (1,1), and the lumped conceptual model TETIS. This latest model has been implemented in its distributed version for comparison purposes and it has been the basis for obtaining information, either through the reconstruction of natural flow series, filling missing data, forecasting or simulation. Hydrological models make use of lumped data of precipitation and potential evapotranspiration, as well as the following parameters for each one of the models which are related to soil properties as capillary storage capacity; the hydraulic saturated conductivity of the upper and lower layers of the soil, and residence times in the flow surface, subsurface layers and base flow. The calibration and the validation process of the models were performed making adjustments to the parameters listed above, taking into account the consistency in the efficiency indexes and the adjustment between the observed and simulated flows using the flow duration curve. The Nash index gave good results for the TETIS model and acceptable values were obtained to the other models. The calibration of the distributed model was complex and its results were similar to those obtained with the aggregated model. This comparison allows planners to use the hydrological multimodel techniques to reduce the uncertainty associated with planning processes in developing countries. Moreover, taking into account the information limitations required to implement a hydrological models, this application can be a
Directory of Open Access Journals (Sweden)
Larry B. Crowder
2011-11-01
Full Text Available Valuing ecosystem services with microeconomic underpinnings presents challenges because these services typically constitute nonmarket values and contribute to human welfare indirectly through a series of ecological pathways that are dynamic, nonlinear, and difficult to quantify and link to appropriate economic spatial and temporal scales. This paper develops and demonstrates a method to value a portion of ecosystem services when a commercial fishery is dependent on the quality of estuarine habitat. Using a lumped-parameter, dynamic open access bioeconomic model that is spatially explicit and includes predator-prey interactions, this paper quantifies part of the value of improved ecosystem function in the Neuse River Estuary when nutrient pollution is reduced. Specifically, it traces the effects of nitrogen loading on the North Carolina commercial blue crab fishery by modeling the response of primary production and the subsequent impact on hypoxia (low dissolved oxygen. Hypoxia, in turn, affects blue crabs and their preferred prey. The discounted present value fishery rent increase from a 30% reduction in nitrogen loadings in the Neuse is $2.56 million, though this welfare estimate is fairly sensitive to some parameter values. Surprisingly, this number is not sensitive to initial conditions.
International Nuclear Information System (INIS)
Tkatschenko, I.; Studer, E.; Paillere, H.
2005-01-01
During a severe accident in a Pressurized Water Reactor (PWR), the formation of a combustible gas mixture in the complex geometry of the reactor depends on the understanding of hydrogen production, the complex 3D thermal-hydraulics flow due to gas/steam injection, natural convection, heat transfer by condensation on walls and effect of mitigation devices. Numerical simulation of such flows may be performed either by Lumped Parameter (LP) or by Computational Fluid Dynamics (CFD) codes. Advantages and drawbacks of LP and CFD codes are well-known. LP codes are mainly developed for full size containment analysis but they need improvements, especially since they are not able to accurately predict the local gas mixing within the containment. CFD codes require a process of validation on well-instrumented experimental data before they can be used with a high degree of confidence. The MISTRA coupled effect test facility has been built at CEA to fulfil this validation objective: with numerous measurement points in the gaseous volume - temperature, gas concentration, velocity and turbulence - and with well controlled boundary conditions. As illustration of both experimental and simulation areas of this topic, a recent example in the use of MISTRA test data is presented for the case of the International Standard Problem ISP47. The proposed experimental work in the MISTRA facility provides essential data to fill the gaps in the modelling/validation of computational tools. (author)
Ceroici, Chris; Zemp, Roger J
2017-07-01
Capacitive micromachined ultrasonic transducers (CMUTs) promise many advantages over traditional piezoelectric transducers such as the potential to construct large, cost-effective 2-D arrays. To avoid wiring congestion issues associated with fully wired arrays, top-orthogonal-to-bottom electrode (TOBE) CMUT array architectures have proven to be a more practical alternative, using only 2N wires for an N ×N array. Optimally designing a TOBE CMUT array is a significant challenge due to the range of parameters from the device level up to the operating conditions of the entire array. Since testing many design variations can be prohibitively expensive, a simulation approach accounting for both the small and large-scale array characteristics of TOBE arrays is essential. In this paper, we demonstrate large-scale TOBE CMUT array simulations using a nonlinear CMUT lumped-circuit model. We investigate the performance of the array with different CMUT design parameters and array operating conditions. These simulated results are then compared with measurements of TOBE arrays fabricated using a sacrificial release process.
Directory of Open Access Journals (Sweden)
Abdalla Hussein Mohamed
2018-03-01
Full Text Available To find the temperature rise for high power density yokeless and segmented armature (YASA axial flux permanent magnet synchronous (AFPMSM machines quickly and accurately, a 3D lumped parameter thermal model is developed and validated experimentally and by finite element (FE simulations on a 4 kW YASA machine. Additionally, to get insight in the thermal transient response of the machine, the model accounts for the thermal capacitance of different machine components. The model considers the stator, bearing, and windage losses, as well as eddy current losses in the magnets on the rotors. The new contribution of this work is that the thermal model takes cooling via air channels between the magnets on the rotor discs into account. The model is parametrized with respect to the permanent magnet (PM angle ratio, the PM thickness ratio, the air gap length, and the rotor speed. The effect of the channels is incorporated via convection equations based on many computational fluid dynamics (CFD computations. The model accuracy is validated at different values of parameters by FE simulations in both transient and steady state. The model takes less than 1 s to solve for the temperature distribution.
Directory of Open Access Journals (Sweden)
Singh U.C.
2013-01-01
Full Text Available In a theoretical analysis, a lump-integral model for freezing and melting of the bath material onto a cylindrical additive having its thermal resistance negligible with respect to that of the bath is developed. It is regulated by independent nondimensional parameters, namely the Stefan number, St the heat capacity ratio, Cr and the modified conduction factor, Cofm. Series solutions associated with short times for time variant growth of the frozen layer and rise in interface temperature between the additive and the frozen layer are obtained. For all times, numerical solutions concerning the frozen layer growth with its melting and increase in the interface temperature are also found. Time for freezing and melting is estimated for different values of Cr, St and Cofm. It is predicted that for lower total time of freezing and melting Cofm<2 or Cr<1 needs to be maintained. When the bath temperature equals the freezing temperature of the bath material, the model is governed by only Cr and St and gives closed-form expressions for the growth of the frozen layer and the interface temperature. For the interface attaining the freezing temperature of the bath material the maximum thickness of the frozen layer becomes ξmax-√Cr(Cr+St. The model is validated once it is reduced to a problem of heating of the additive without freezing of the bath material onto the additive. Its closed-form solution is exactly the same as that reported in the literature.
Liu, An; Goonetilleke, Ashantha; Egodawatta, Prasanna
2012-01-01
Stormwater quality modeling results are subject to uncertainty. The variability of input parameters is an important source of overall model error. An in-depth understanding of the variability associated with input parameters can provide knowledge on the uncertainty associated with these parameters and can assist in uncertainty analysis of stormwater quality models and decision making based on modeling outcomes. This paper discusses the outcomes of a research study undertaken to analyze the variability related to pollutant build-up parameters in stormwater quality modeling. The study was based on the analysis of pollutant build-up samples collected from 12 road surfaces in residential, commercial, and industrial land uses. It was found that build-up characteristics vary appreciably even within the same land use. Therefore, using land use as a lumped parameter would contribute significant uncertainties in stormwater quality modeling. Additionally, it was found that the variability in pollutant build-up can be significant depending on the pollutant type. This underlines the importance of taking into account specific land use characteristics and targeted pollutant species when undertaking uncertainty analysis of stormwater quality models or in interpreting the modeling outcomes. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.
International Nuclear Information System (INIS)
George, Glenn R.
2006-01-01
The Energy Policy Act of 2005 is an important development in the financing of new nuclear capacity in the near- to mid-term in the U.S.A. Key features of the Act, including production tax credits, loan guarantees, funding support, and 'standby support', are intended to provide significant incentives for new nuclear development, construction, and operation. There is a mismatch, however, between the nature and extent of incentives being offered and what is needed to spur nuclear plant deployment in light of power market uncertainty, utility investor wariness, and the need to raise significant capital before a nuclear construction project can be launched. In this paper, the author addresses these issues through the lens of financial tools and techniques. The paper considers various ways in which long-term streams of subsidies can be transformed into up-front financing for new nuclear capacity. Securing and related financial structures are among the mechanisms considered for potentially bridging the temporal gap between flows of financial benefits conferred legislatively and lumps of capital required by developers and investors in advance of a construction program. (authors)
Formulation and Characterization of Sustained Release Floating ...
African Journals Online (AJOL)
Purpose: To formulate sustained release gastroretentive microballoons of metformin hydrochloride with the objective of improving its bioavailability. Methods: Microballoons of metformin hydrochloride were formulated by solvent evaporation and diffusion method using varying mixtures of hydroxypropyl methylcellulose ...
Perfume formulation: words and chats.
Ellena, Céline
2008-06-01
What does it mean to create fragrances with materials from chemistry and/or from nature? How are they used to display their characteristic differences, their own personality? Is it easier to create with synthetic raw materials or with essential oils? This review explains why a perfume formulation corresponds in fact to a conversation, an interplay between synthetic and natural perfumery materials. A synthetic raw material carries a single information, and usually is very linear. Its smell is uniform, clear, and faithful. Natural raw materials, on the contrary, provide a strong, complex and generous image. While a synthetic material can be seen as a single word, a natural one such as rose oil could be compared to chatting: cold, warm, sticky, heavy, transparent, pepper, green, metallic, smooth, watery, fruity... full of information. Yet, if a very small amount of the natural material is used, nothing happens, the fragrance will not change. However, if a large amount is used, the rose oil will swallow up everything else. The fragrance will smell of nothing else except rose! To formulate a perfume is not to create a culinary recipe, with only dosing the ingredients in well-balanced amounts. To formulate rather means to flexibly knit materials together with a lively stitch, meeting or repelling each other, building a pleasant form, which is neither fixed, nor solid, nor rigid. A fragrance has an overall structure, which ranges from a clear sound, made up of stable, unique, and linear items, to a background chat, comfortable and reassuring. But that does, of course, not mean that there is only one way of creating a fragrance!
Formulation of soy oil products
Directory of Open Access Journals (Sweden)
Woerfel, John B.
1995-12-01
Full Text Available The paper comments different formulations of soy oil products such as salad and cooking oils, margarine, shortenings, commercial shortenings, frying shortenings, and fluid shortenings. Hydrogenation and its influence on final products is also included.
El trabajo presenta diferentes formulaciones a base de aceite de soja tales como aceites para ensalada y cocinado, margarina, grasas sólidas (shortenings, grasas sólidas comerciales, grasas sólidas para frituras y grasas fluidas. Hace también referencia al proceso de hidrogenación y a sus efectos en los productos finales.
Directory of Open Access Journals (Sweden)
Vasu Reddy Challa
2013-01-01
Full Text Available Background. Breast lumps have varied pathology, and there are different techniques to prove the diagnosis. The aim of the present study is to analyze the role of fine needle aspiration cytology (FNAC of the breast lesions at our center. Methods. We had retrospectively analysed 854 patients who underwent FNAC for primary breast lumps and 190 patients who underwent FNAC for an axillary lymph node in the year 2010. Results. Of 854 patients, histological correlation was available in 723 patients. The analysis was done for 812 patients as medical records were not available for 42 patients. FNAC was false negative in seven cases; 2 cases of phyllodes were reported as fibroadenoma, and 5 cases of carcinoma were diagnosed as atypical hyperplasia. The sensitivity, specificity, and false negative value of FNAC in diagnosing breast lumps were 99% (715/723, 100%, and 1%, respectively. Of 190 patients for whom FNAC was performed for axilla, 170 had proven to have axillary lymph node metastases, and the rest had reactive hyperplasia or inflammatory cells. Conclusions. FNAC is rapid, accurate, outpatient based, and less complicated procedure and helps in diagnosis of breast cancer, benign diseases, and axillary involvement in experienced hands with less chance of false results.
Formulation, Preparation, and Characterization of Polyurethane Foams
Pinto, Moises L.
2010-01-01
Preparation of laboratory-scale polyurethane foams is described with formulations that are easy to implement in experiments for undergraduate students. Particular attention is given to formulation aspects that are based on the main chemical reactions occurring in polyurethane production. This allows students to develop alternative formulations to…
Performance Evaluation of Abrasive Grinding Wheel Formulated ...
African Journals Online (AJOL)
This paper presents a study on the formulation and manufacture of abrasive grinding wheel using locally formulated silicon carbide abrasive grains. Six local raw material substitutes were identified through pilot study and with the initial mix of the identified materials, a systematic search for an optimal formulation of silicon ...
McCarrick, H.; Jones, G.; Johnson, B. R.; Abitbol, M. H.; Ade, P. A. R.; Bryan, S.; Day, P.; Essinger-Hileman, T.; Flanigan, D.; Leduc, H. G.; Limon, M.; Mauskopf, P.; Miller, A.; Tucker, C.
2018-02-01
Aims: Lumped-element kinetic inductance detectors (LEKIDs) are an attractive technology for millimeter-wave observations that require large arrays of extremely low-noise detectors. We designed, fabricated and characterized 64-element (128 LEKID) arrays of horn-coupled, dual-polarization LEKIDs optimized for ground-based CMB polarimetry. Our devices are sensitive to two orthogonal polarizations in a single spectral band centered on 150 GHz with Δν/ν = 0.2. The 65 × 65 mm square arrays are designed to be tiled into the focal plane of an optical system. We demonstrate the viability of these dual-polarization LEKIDs with laboratory measurements. Methods: The LEKID modules are tested with an FPGA-based readout system in a sub-kelvin cryostat that uses a two-stage adiabatic demagnetization refrigerator. The devices are characterized using a blackbody and a millimeter-wave source. The polarization properties are measured with a cryogenic stepped half-wave plate. We measure the resonator parameters and the detector sensitivity, noise spectrum, dynamic range, and polarization response. Results: The resonators have internal quality factors approaching 1 × 106. The detectors have uniform response between orthogonal polarizations and a large dynamic range. The detectors are photon-noise limited above 1 pW of absorbed power. The noise-equivalent temperatures under a 3.4 K blackbody load are 80%. The entire array is multiplexed on a single readout line, demonstrating a multiplexing factor of 128. The array and readout meet the requirements for 4 arrays to be read out simultaneously for a multiplexing factor of 512. Conclusions: This laboratory study demonstrates the first dual-polarization LEKID array optimized specifically for CMB polarimetry and shows the readiness of the detectors for on-sky observations.
Chen, X.; Comas, X.; Binley, A. M.; Slater, L. D.
2017-12-01
Methane can accumulate in the gaseous phase in peats, and enter the atmosphere as gas bubbles with a mass flux higher than that via diffusion and plant-mediated pathways. A complete understanding of the mechanisms regulating bubble storage in peats remains incomplete. We developed a layered model to quantify the storage of gas bubbles over a peat column based on a general lumped capacitance model. This conceptual model was applied to explain the effects of peat structure on bubble storage at different depths observed in a laboratory experiment. A peat monolith was collected from the Everglades, a subtropical wetland located in Florida (USA), and kept submerged in a cuboid chamber over 102 days until gas bubble saturation was achieved. Time-lapse ground-penetrating radar (GPR) was used to estimate changes in gas content of each layer and the corresponding average dimensions of stored gas bubbles. The results highlight a hotspot layer of bubble accumulation at depths between 5 and 10 cm below the monolith surface. Bubbles in this shallow hotspot layer were larger relative to those in deeper layers, whilst the degree of decomposition of the upper layers was generally smaller than that of the lower layers based on von Post humification tests. X-ray Computer tomography (CT) was applied to resin-impregnated peat sections from different depths and the results showed that a higher porosity promotes bubbles storage. The stored gas bubbles were released by changing water levels and the air CH4 concentrations above the peat monolith were measured using a flow-through chamber system to confirm the high CH4 concentration in the stored bubbles. Our findings suggest that bubble capacitance is related to the difference in size between gas bubbles and peat pores. This work has implications for better understanding how changes in water table elevation associated with climate change and sea level rise (particularly for freshwater wetlands near coastal areas like the Everglades) may
Investigation of the 18F-2FDG/glucose lumped constant behavior in isolated working rat hearts
International Nuclear Information System (INIS)
Ng, Chin Kau.
1989-01-01
The behavior of the 18 F-2FDG/Glucose lumped constant (LC) in heart was investigated using an improved isolated perfused working rat heart model, quantitative external counting of total tissue radioactivity by fast coincidence detection of positron-emitting radionuclides, and digital compartmental modeling of tracer kinetics. The ability of the 2FDG compartmental model to predict the time courses of the fractions of the total radioactivity attributable to 2FDG6-phosphate was biochemically validated for six perfusion conditions by directly assaying the 2FDG-6-phosphate fractions from acid extractions of freeze-clamped myocardial tissue. In 14 C 2FDG recirculation experiments, chromatographic analyses indicated that the only two significant species in the myocardium were 14 C 2FDG and 14 C 2FDG-6phosphate. The use of 2-[ 3 H]glucose for measuring glucose phosphorylation rates was also validated by correlating steady-state tritiated water production with enzymatic assay of glucose disappearance. From constant infusion experiments, the values of the LC were determined to be 0.942 ± 0.062, 0.770 ± 0.166, 1.191 ± 0.054, 0.685 ± 0.093, and 0.334 ± 0.026, for hearts perfused with 5 and 30 mM glucose without insulin, and 2, 3.5, and 5 mM glucose with insulin respectively. The monotonic decrease of the LC as glucose concentration is increased in the presence of insulin can be explained by the shift in control strength for glucose uptake between membrane transport and the phosphorylation reaction. Bolus injection experiments analyzed with compartmental models indicated the occurrence of the following sequence: limited glucose supply relative to metabolic demand; decreased cellular glucose content; increased importance of the transport process in the limitation of hexose uptake; increased value for the LC
An Efficient Boundary Integral Formulation for Flow Through Fractured Porous Media
Lough, M. F.; Lee, S. H.; Kamath, J.
1998-07-01
In this paper we present a new model for flow in fractured porous media. We formulate our model in terms of a coupled system of boundary integral equations and present an efficient procedure for solving the equations using the boundary element method. In the new model, the flow in the matrix is governed by the usual Darcy law for porous media, with the fractures being treated as planar sources embedded in the matrix. The flow in an individual fracture is governed by a two-dimensional Darcy law (as in a Hele-Shaw cell), with an associated planar sink distribution. The essential feature of this approach is that the fractures are treated as special planes rather than narrow-gap voids. The error in the resulting system of equations is on the order of an intrinsic dimensionless parameter (the ratio of the fracture gap size to the scale of the volume under consideration). We also describe how we adapt the new model to compute effective grid block permeabilities. This was the principal motivation behind the development of the new model. Using effective grid block permeabilities to model flow in fractured oil and gas reservoirs is a much more efficient process than modeling the flow when every fracture is precisely represented. We present some numerical examples that illustrate the new flow model and how it is used to model flow in a reservoir.
Multiple excitation of supports - Part 1. Formulation
International Nuclear Information System (INIS)
Galeao, A.C.N.R.; Barbosa, H.J.C.
1980-12-01
The formulation and the solution of a simple specific problem of support movement are presented. The formulation is extended to the general case of infinitesimal elasticity where the approximated solutions are obtained by the variational formulation with spatial discretization by Finite Element Method. Finally, the present usual numerical techniques for the treatment of the resulting ordinary differential equations system are discused: Direct integration, Modal overlap, Spectral response. (E.G.) [pt
Formulation of disperse systems science and technology
Tadros, Tharwat F
2014-01-01
This book presents comprehensively the science and technology behind the formulation of disperse systems like emulsions, suspensions, foams and others. Starting with a general introduction, the book covers a broad range of topics like the role of different classes of surfactants, stability of disperse systems, formulation of different dispersions, evaluation of formulations and many more. Many examples are included, too. Written by the experienced author and editor Tharwart Tadros, this book is indispensable for every scientist working in the field.
... clips will be placed inside the breast to mark the area of tissue removal. This makes the ... Abeloff's Clinical Oncology. 5th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 23. Hunt KK, Mittendorf EA. Diseases ...
Singha, Sanat K; Das, Prasanta K; Maiti, Biswajit
2017-06-21
The effect of contact line pinning on nucleation is reported using continuum thermodynamics. Based on the principle of the free-energy maximization, closed-form expressions in the dimensionless form for the free-energy of the three-phase metastable system and the thermodynamic barrier are formulated with respect to the system geometry and the substrate wettability. The condition of maximality limits the dynamic contact angle within the cluster-phase-phobic regime. The dimensionless nucleation barrier or the potency factor can be divided into two components related to the system geometry and the pinning effect. Depending on the relative value of the equilibrium and the critical dynamic contact angle, the contact line pinning can either have favorable or adverse effects. Associated pinning-depinning transition can also lead to the crossovers related to barrierless and homogeneous nucleation. Contact line tension is found to have a considerable effect during these transitional scenarios. Complete wetting transition associated with barrierless nucleation can take place due to the presence of tensile (negative) line tension. On the other hand, complete drying transition related to homogeneous nucleation can occur when line tension is compressive (positive) in nature. The pinning has a favorable effect only when the substrate wettability is within the cluster-phase-philic regime. There can be favorable, adverse, or no pinning effects when the substrate wettability is within the cluster-phase-phobic regime. Although the contact line is pinned, the minimum value of the potency factor is obtained when equilibrium and dynamic contact angles are equal.
Spray granulation for drug formulation.
Loh, Zhi Hui; Er, Dawn Z L; Chan, Lai Wah; Liew, Celine V; Heng, Paul W S
2011-12-01
Granulation is a key unit process in the production of pharmaceutical solid dosage forms and involves the agglomeration of fine particles with the aid of a binding agent. Fluidized bed granulation, a classic example of spray granulation, is a technique of particle agglomeration brought about by the spray addition of the binding liquid onto a stationary bed of powder particles that is transformed to a fluid-like state by the passage of air through it. The basic working principles, equipment set-up, advantages and challenges of fluidized bed granulation are introduced in this review. This is followed by an overview of the formulation and process-related variables affecting granulation performance. Technological advances, particularly in the application of process analytical tools, in the field of fluidized bed granulation research are also discussed. Fluidized bed granulation is a popular technique for pharmaceutical production, as it is a highly economical and efficient one-pot process. The research and development of process analytical technologies (PAT) has allowed greater process understanding and control to be achieved, even for the lesser known fluidized bed techniques, such as bottom spray and fluidized hot melt granulation. In view of its consistent mixing, as well as continuous and concurrent wetting and drying occurring throughout processing, fluidized bed granulation shows great potential for continuous production although more research is required to fully implement, validate and integrate the PAT tools in a production line.
Policy formulation of public acceptance
International Nuclear Information System (INIS)
Kasai, Akihiro
1978-01-01
Since 1970, the new policy formulation for public acceptance of the new consideration on the location of electric power generation has been set and applied. The planning and the enforcement being conducted by local public organizations for the local economic build-up with plant location and also the adjustement of the requirements for fishery are two main specific characters in this new policy. The background of this new public acceptance policy, the history and the actual problems about the compensation for the location of power generation plants are reviewed. One new proposal, being recommended by the Policy and Science Laboratory to MITI in 1977 is explained. This is based on the method of promoting the location of power generation plants by public participation placing the redevelopment of regional societies as its basis. The problems concerning the industrial structures in farm villages, fishing villages and the areas of commerce and industry should be systematized, and explained from the viewpoint of outside impact, the characteristics of local areas and the location problems in this new proposal. Finally, the location process and its effectiveness should be put in order. (Nakai, Y.)
Slag-based saltstone formulations
International Nuclear Information System (INIS)
Langton, C.A.
1987-01-01
Approximately 400 x 10 6 liters of low-level alkaline salt solution will be treated at the Savannah River Plant (SRP) Defense Waste Processing Facility (DWPF) prior to disposal in concrete vaults at SRP. Treatment involves removal of CS + and Sr +2 followed by solidification and stabilization of potential contaminants in saltstone, a hydrated ceramic waste form. Chromium, technetium, and nitrate releases from saltstone can be significantly reduced by substituting hydraulic blast furnace slag for portland cement in the formulation designs. Slag-based mixes are also compatible with Class F fly ash used in saltstone as a functional extender to control heat of hydration and reduce permeability. A monolithic waste form is produced by the hydration of the slag and fly ash. Soluble ion release (NO 3 - ) is controlled by the saltstone microstructure. Chromium and technetium are less leachable from slag mixes compared to cement-based waste forms because these species are chemically reduced to a lower valence state by ferrous iron in the slag and precipitated as relatively insoluble phases, such as CR(OH) 3 and TcO 2 . 5 refs., 4 figs., 4 tabs
Pediatric drug development: formulation considerations.
Ali, Areeg Anwer; Charoo, Naseem Ahmad; Abdallah, Daud Baraka
2014-10-01
Absence of safe, effective and appropriate treatment is one of the main causes of high mortality and morbidity rates among the pediatric group. This review provides an overview of pharmacokinetic differences between pediatric and adult population and their implications in pharmaceutical development. Different pediatric dosage forms, their merits and demerits are discussed. Food and Drug Administration Act of 1997 and the Best Pharmaceuticals for Children Act 2002 added 6 months patent extension and exclusivity incentives to pharmaceutical companies for evaluation of medicinal products in children. Prescription Drug User Fee Act and Food and Drug Administration Amendments Act of 2007 made it mandatory for pharmaceutical companies to perform pediatric clinical studies on new drug products. Drug development program should include additional clinical bridge studies to evaluate differences in pharmacokinetics and pharmacodynamics of drugs in adult and child populations. Additionally, pharmaceutical development should consider ease of administration, palatability, appropriate excipients, stability and therapeutic equivalency of pediatric dosage forms. Pediatric population is diverse with individual preferences and demand for custom made dosage formulations. Practically it is not feasible to have different pharmaceutical dosage forms for each group. Hence, an appropriate dosage form that can be administered across pediatric population is warranted.
Energy Technology Data Exchange (ETDEWEB)
Moya, Sara L.; Iglesias, Eduardo R.; Aragon, Alfonso [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)
1995-09-01
A numerical research over the contribution of the rock-fluid medium of geothermal reservoirs to mass and energy productivities of geothermal wells is made. This considering the effect of carbon dioxide and a wide range of rock matrix and fluid properties, pressure-temperature initial conditions and exploitation state of reservoir. The results are shown in form of inflow characteristics curves interrelating flowing pressure in the interface well-reservoir and the produced enthalpy with discharged mass flow. Normalizing these curves with their respective maximum values, two dimensionless curves are obtained which are proposed as reference curves to estimate the mass and energy productivities of geothermal wells. Both proposed reference curves are independents of reservoir parameters and the produced cumulative mass. [Espanol] Se investiga numericamente la contribucion del medio roca-fluido de los yacimientos geotermicos a las productividades de masa y energia de los pozos geotermicos. Se considera el efecto del bioxido de carbono y de un amplio intervalo de propiedades de la formacion rocosa y del fluido, de las condiciones iniciales de presion y temperatura, y del grado de explotacion del yacimiento. Los resultados se muestran en forma de curva caracteristicas de influjo que relacionan la presion fluyente en la intercara pozo-yacimiento y la entalpia producida, con la velocidad de flujo masico producido. Normalizando estas curvas con los correspondientes valores maximos, se obtienen dos curvas adimensionales las cuales se proponen como curvas de referencia para estimar las productividades de masa y energia de los pozos geotermicos. Las dos curvas de referencia propuestas son independientes de los parametros del yacimiento y del porcentaje de masa producida acumulada.
Dewi Tristantini; Ricky Kristanda Suwignjo
2016-01-01
This study investigated lump kinetic analysis of Fischer-Tropsch synthesis over Cobalt and Cobalt-Rhenium Alumina supported catalyst (Co/γ-Al2O3 and Co-Re/γ-Al2O3) at 20 bars and 483 K using feed gas with molar H2/CO ratios of 1.0 to 2.1. Syngas with H2/CO molar ratio of 1.0 represents syngas characteristic derived from biomass, while the 2.1 molar ratio syngas derived from coal. Rhenium was used as the promoter for the cobalt catalyst. Isothermal Langmuir adsorption mechanism was used to bui...
Directory of Open Access Journals (Sweden)
Dewi Tristantini
2016-03-01
Received: 10th November 2015; Revised: 10th February 2016; Accepted: 16th February 2016 How to Cite: Tristantini, D., Suwignjo, R.K. (2016. Lump Kinetic Analysis of Syngas Composition Effect on Fischer-Tropsch Synthesis over Cobalt and Cobalt-Rhenium Alumina Supported Catalyst. Bulletin of Chemical Reaction Engineering & Catalysis, 11 (1: 84-92. (doi:10.9767/bcrec.11.1.424.84-92 Permalink/DOI: http://dx.doi.org/10.9767/bcrec.11.1.424.84-92
Energy Technology Data Exchange (ETDEWEB)
Baldessar, Fabio; Negrao, Cezar O. Ribeiro; Palu, Claudia [Centro Federal de Educacao Tecnologica do Parana (CEFET-PR), Curitiba, PR (Brazil)
2004-07-01
The current work presents a mathematical model of an ascendant flow vertical reactor (riser) of a Fluid Catalytic Cracking Unit. The two-phase flow (gas-solid) and the cracking reactions are admitted one-dimensional and steady state. Mass, momentum and energy conservation equations are considered for each phase (solid and gas). A six-lump kinetic model is employed to evaluate gasoil, gasoline, GLP, fuel gas, light cycle oil and coke fractions. The model results are compared to experimental values from a pilot plant and to another model found in the literature. The results are in good agreement, showing the model has great potential. (author)
International Nuclear Information System (INIS)
Dubrovsky, V.G.; Formusatik, I.B.
2003-01-01
The scheme for calculating via Zakharov-Manakov ∂-macron-dressing method of new rational solutions with constant asymptotic values at infinity of the famous two-dimensional Veselov-Novikov (VN) integrable nonlinear evolution equation and new exact rational potentials of two-dimensional stationary Schroedinger (2DSchr) equation with multiple pole wave functions is developed. As examples new lumps of VN nonlinear equation and new exact rational potentials of 2DSchr equation with multiple pole of order two wave functions are calculated. Among the constructed rational solutions are as nonsingular and also singular
Glass Ceramic Formulation Data Package
Energy Technology Data Exchange (ETDEWEB)
Crum, Jarrod V.; Rodriguez, Carmen P.; McCloy, John S.; Vienna, John D.; Chung, Chul-Woo
2012-06-17
A glass ceramic waste form is being developed for treatment of secondary waste streams generated by aqueous reprocessing of commercial used nuclear fuel (Crum et al. 2012b). The waste stream contains a mixture of transition metals, alkali, alkaline earths, and lanthanides, several of which exceed the solubility limits of a single phase borosilicate glass (Crum et al. 2009; Caurant et al. 2007). A multi-phase glass ceramic waste form allows incorporation of insoluble components of the waste by designed crystallization into durable heat tolerant phases. The glass ceramic formulation and processing targets the formation of the following three stable crystalline phases: (1) powellite (XMoO4) where X can be (Ca, Sr, Ba, and/or Ln), (2) oxyapatite Yx,Z(10-x)Si6O26 where Y is alkaline earth, Z is Ln, and (3) lanthanide borosilicate (Ln5BSi2O13). These three phases incorporate the waste components that are above the solubility limit of a single-phase borosilicate glass. The glass ceramic is designed to be a single phase melt, just like a borosilicate glass, and then crystallize upon slow cooling to form the targeted phases. The slow cooling schedule is based on the centerline cooling profile of a 2 foot diameter canister such as the Hanford High-Level Waste canister. Up to this point, crucible testing has been used for glass ceramic development, with cold crucible induction melter (CCIM) targeted as the ultimate processing technology for the waste form. Idaho National Laboratory (INL) will conduct a scaled CCIM test in FY2012 with a glass ceramic to demonstrate the processing behavior. This Data Package documents the laboratory studies of the glass ceramic composition to support the CCIM test. Pacific Northwest National Laboratory (PNNL) measured melt viscosity, electrical conductivity, and crystallization behavior upon cooling to identify a processing window (temperature range) for melter operation and cooling profiles necessary to crystallize the targeted phases in the
Chemicals-Based Formulation Design: Virtual Experimentations
DEFF Research Database (Denmark)
Conte, Elisa; Gani, Rafiqul
2011-01-01
This paper presents a systematic procedure for virtual experimentations related to the design of liquid formulated products. All the experiments that need to be performed when designing a liquid formulated product (lotion), such as ingredients selection and testing, solubility tests, property...... measurements, can now be performed through the virtual Product-Process Design laboratory [[1], [2] and [3
Colorimetric analysis of hexachlorophene in topical formulations.
French, W N; Matsui, F; Smith, S J; Wood, R J
1975-01-01
The commonly used 4-aminoantipyrine dye formation procedure for hexachlorophene analysis in topical formulations was modified to overcome interference due to other components. Bar soaps and nonemulsion formulations are analyzed directly, employing a chloroform back-extraction stage of the dye prior to quantitation. Hexachlorophene in emulsions and liquid soaps is determined using a TLC separation prior to dye formation.
40 CFR 152.43 - Alternate formulations.
2010-07-01
... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Alternate formulations. 152.43 Section 152.43 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE REGISTRATION AND CLASSIFICATION PROCEDURES Registration Procedures § 152.43 Alternate formulations...
Formulation and characterization of modified release tablets ...
African Journals Online (AJOL)
Formulation with 35% polymer content exhibited zero order release profile and it released 35% of the drug in first hr, later on, controlled drug release was observed upto the 12th hour. Formulations with PVAc to Na-CMC ratio 20:80 exhibited zero order release pattern at levels of studied concentrations, which suggested that ...
A New Resistance Formulation for Carbon Nanotubes
Directory of Open Access Journals (Sweden)
Ji-Huan He
2008-01-01
Full Text Available A new resistance formulation for carbon nanotubes is suggested using fractal approach. The new formulation is also valid for other nonmetal conductors including nerve fibers, conductive polymers, and molecular wires. Our theoretical prediction agrees well with experimental observation.
Energy Technology Data Exchange (ETDEWEB)
Miyatake, Osamu; Tagawa, Kotaro; Noda, Hidehiko [Kyushu University, Fukuoka (Japan)
1999-08-01
Based on the authors' previous numerical results of a reverse osmosis desalination system for seawater or brackish water utilizing the static pressure head of seawater in a deep-sea region or brackish water in a vertical pit, a dimensionless expression is formulated to predict the transmitted fresh water flow rate from the geometry and the submerged depth of the device, the pure water permeability and the solute permeability of membrane, and the physical properties properties of seawater or brackish water. The derived expression is compared with experimental results obtained by field experiments carried out in the Sea of Japan and the East China with fair agreement and thus confirmed the applicability and usefulness of the expression. (author)
Pankow, James F.; Niakan, Negar; Asher, William E.
2013-12-01
Many current models that aim to predict urban and regional levels of organic particulate matter (OPM) use either the 2 product (2p) framework for secondary organic aerosol (SOA) formation, or a static 1-D volatility basis set (1-D-VBS). These approaches assume that: 1) the compounds involved in OPM condensation/evaporation can be lumped simply by volatility with no specificity regarding carbon number nC, MW, or polar functionality; 2) water uptake does not occur; and 3) the compounds are non-ionizing. This work considers the consequences for uniphasic PM caused by the first two assumptions due to effects of the condensed-phase mean molecular weight MWbar and activity coefficients (ζi), including when RH (relative humidity) > 0. Setting nC = 10 for all bins, multiple chemical structures were developed for each bin of a 1-D-VBS for un-aged SOA in the α-pinene/ozone system. For each bin, a group-contribution vapor pressure (pLo) prediction method was used to find multiple structures such that the groups-based log pLo for nC = 10 and variable numbers of aldehyde, ketone, hydroxyl, and carboxylic acid groups agrees, within ±0.5, with the bin volatility. The number of possible combinations with one structure taken from each bin was 17,640. The Raster-Roulette Organic Aerosol (RROA) model was used to calculate the equilibrium mass concentrations (μg m-3) of OPM (Mo) and co-condensed water (Mw) at 25 °C for each combination for ranges of RH and ΔHC (change in parent hydrocarbon concentration). UNIFAC was used to determine the needed values of ζi. Frequency distributions from RROA for Mo, Mw, and the O:C ratio were developed. For Mo levels typical of the ambient atmosphere, then for the 1-D-VBS and all bins constrained at nC = 10, significant RH-induced enhancement of OPM condensation was observed in the distributions. The spread of the distributions was found to increase rapidly as the level of OPM decreased. The within-bin spread of ±0.5 log units in the groups
Cong, Zhang
2018-03-01
Based on extended state observer, a novel and practical design method is developed to solve the distributed cooperative tracking problem of higher-order nonlinear multiagent systems with lumped disturbance in a fixed communication topology directed graph. The proposed method is designed to guarantee all the follower nodes ultimately and uniformly converge to the leader node with bounded residual errors. The leader node, modeled as a higher-order non-autonomous nonlinear system, acts as a command generator giving commands only to a small portion of the networked follower nodes. Extended state observer is used to estimate the local states and lumped disturbance of each follower node. Moreover, each distributed controller can work independently only requiring the relative states and/or the estimated relative states information between itself and its neighbors. Finally an engineering application of multi flight simulators systems is demonstrated to test and verify the effectiveness of the proposed algorithm. Copyright © 2018 ISA. Published by Elsevier Ltd. All rights reserved.
Energy Technology Data Exchange (ETDEWEB)
Petit, M.; Durin, M.; Gauvain, J. [Commissariat a l`Energie Atomique, Gif sur Yvette (France)
1995-09-01
In many countries, the safety requirements for future light water reactors include accounting for severe accidents in the design process. As far as the containment is concerned, the design must now include mitigation features to limit the pressure and temperature inside the building. Hydrogen concentration is also a major issue for severe accidents. In this context, new needs appear for the modeling of the thermal hydraulics inside the containment. It requires the description of complex phenomena such as condensation, stratification, transport of gases and aerosols, heat transfers. Moreover, the effect of mitigation systems will increase the heterogeneities in the building, and most of those phenomena can be coupled, as for example hydrogen stratification and condensation. To model such a complex situation, the use of multi-dimensional computer codes seems to be necessary in case of large volumes. The aim of the GEYSER/TONUS computer code is to fulfill this need. This code is currently under development at CEA in Saclay. It will allow the coupling of parts of the containment described in a lumped parameter manner, together with meshed parts. Emphasis is put on the numerical methods used to solve the transient problem, as the objective is to be able to treat complete scenarios. Physical models of classical lumped parameters codes will adapted for the spatially described zones. The code is developed in the environment of the CASTEM 2000/TRIO EF system which allows, thanks to its modular conception, to construct sophisticated applications based upon it.
Isotretinoin Oil-Based Capsule Formulation Optimization
Directory of Open Access Journals (Sweden)
Pi-Ju Tsai
2013-01-01
Full Text Available The purpose of this study was to develop and optimize an isotretinoin oil-based capsule with specific dissolution pattern. A three-factor-constrained mixture design was used to prepare the systemic model formulations. The independent factors were the components of oil-based capsule including beeswax (X1, hydrogenated coconut oil (X2, and soybean oil (X3. The drug release percentages at 10, 30, 60, and 90 min were selected as responses. The effect of formulation factors including that on responses was inspected by using response surface methodology (RSM. Multiple-response optimization was performed to search for the appropriate formulation with specific release pattern. It was found that the interaction effect of these formulation factors (X1X2, X1X3, and X2X3 showed more potential influence than that of the main factors (X1, X2, and X3. An optimal predicted formulation with Y10 min, Y30 min, Y60 min, and Y90 min release values of 12.3%, 36.7%, 73.6%, and 92.7% at X1, X2, and X3 of 5.75, 15.37, and 78.88, respectively, was developed. The new formulation was prepared and performed by the dissolution test. The similarity factor f2 was 54.8, indicating that the dissolution pattern of the new optimized formulation showed equivalence to the predicted profile.
Formulation of heat absorbing glasses
Directory of Open Access Journals (Sweden)
Álvarez-Casariego, Pedro
1996-06-01
Full Text Available In the thermal exchanges between buildings and environment, glazing is an element of major importance, for it largely influences the so-called Solar Heat Gain and Thermal Losses. These parameters can be modified by applying different type of coatings onto glass surface or by adding colorant compounds during glass melting.
The latter is a cheaper way to control the Solar Heat Gain. The knowledge of the laws governing the interaction between colorant compounds and solar radiation, allows us to define glass formulations achieving specific aesthetic requirements and solar energy absorption.
In this paper two examples of application of the modelling of glass colorants spectral absorptance are presented. First is addressed to obtaining a glass with high luminous transmittance and low solar energy transmittance, and the other one to obtaining a glass with neutral colour appearance and minimized solar energy transmittance. Calculation formulas are defined together with photometric properties so-obtained. These type of glasses are particularly suitable to be used as building and automotive glazing, for they retain the mechanical characteristics and possibilities of transformation of standard glass.
En los intercambios de energía entre un edificio y el medio exterior, el vidrio es el elemento de mayor importancia, por su influencia en la Ganancia de Calor Solar y en las Pérdidas Térmicas. Estos parámetros pueden ser modificados mediante el depósito de capas sobre el vidrio o mediante la adición de compuestos absorbentes de la radiación solar.
Esta última vía es la más económica para controlar la Ganancia de Calor Solar. El conocimiento de las leyes que gobiernan la interacción de los diversos colorantes con la radiación solar, permite definir formulaciones de vidrios con características especificas de tipo estético y de absorción energética.
En este trabajo se presentan dos ejemplos de aplicación de esta modelización de las
Canonical operator formulation of nonequilibrium thermodynamics
International Nuclear Information System (INIS)
Mehrafarin, M.
1992-09-01
A novel formulation of nonequilibrium thermodynamics is proposed which emphasises the fundamental role played by the Boltzmann constant k in fluctuations. The equivalence of this and the stochastic formulation is demonstrated. The k → 0 limit of this theory yields the classical deterministic description of nonequilibrium thermodynamics. The new formulation possesses unique features which bear two important results namely the thermodynamic uncertainty principle and the quantisation of entropy production rate. Such a theory becomes indispensable whenever fluctuations play a significant role. (author). 7 refs
Preformulation and Formulation of Investigational New Drugs
1985-07-01
bilock number) -his annual report contains preformulation and formulation studies on WR249,655.2CL’ C141-6s2CI) , WR238,605, WR171,669’HCI...RMI-S ltr, 31 Jul 1992 THIS PAGE IS UNCLASSIFIED O0hK ri~t. GUt*Y . 00 Preformulation and Formulation of Investigational New Drugs Annual Progress...63764D99 BB 049 1I. ITLE (InCIu7* SOcurity Cfa.811 fcotIOn) (U) Preformulation and Formulation of Investigational New Drugs 13¶. PERSONAL AUTHORl Lach
DEFF Research Database (Denmark)
Matzen, René
2011-01-01
formulation based on the second‐order wave equation with displacements as the only unknowns to annihilate spurious reflections from near‐grazing waves. The derived variational form allows for the use of e.g. finite element and the spectral element methods as spatial discretization schemes. A recursive...... convolution update scheme of second‐order accuracy is employed such that highly stable, effective time integration with the Newmark‐beta (implicit and explicit with mass lumping) method is achieved. The implementation requires minor modifications of existing displacement‐based finite element software......The perfectly matched layer (PML) technique has demonstrated very high efficiency as absorbing boundary condition for the elastic wave equation recast as a first‐order system in velocity and stress in attenuating non‐grazing bulk and surface waves. This paper develops a novel convolutional PML...
Hamiltonian formulation for conformal p-branes
Energy Technology Data Exchange (ETDEWEB)
Alvear, C.; Amorim, R.; Barcelos-Neto, J. (Inst. de Fisica, Univ. Federal do Rio de Janeiro (Brazil))
1991-12-26
We study the hamiltonian formulation for conformal p-branes. The difficulties which could arise from the substitution of velocities in terms of momenta, due to the nonlinearity of the theory, an circumvented. (orig.).
A Hamiltonian formulation for elasticity and thermoelasticity
Maugin, G A
2002-01-01
A Hamiltonian formulation for elasticity and thermoelasticity is proposed and its relation with the corresponding configurational setting is examined. Firstly, a variational principle, concerning the 'inverse motion' mapping, is formulated and the corresponding Euler-Lagrange equations are explored. Next, this Lagrangian formulation is used to define the Hamiltonian density function. The equations of Hamilton are derived in a form which is very similar to the one of the corresponding equations in particle mechanics (finite-dimensional case). From the Hamiltonian formulation it follows that the canonical momentum is identified with the pseudomomentum. Furthermore, a meaning for the Poisson bracket is defined and the entailed relations with the canonical variables as well as the balance laws are examined.
Understanding Pesticide Risks: Toxicity and Formulation
Muntz, Helen; Miller, Rhonda; Alston, Diane
2016-01-01
This fact sheet provides information about pesticide risks to human health, primary means of pesticide exposure, standardized measures of pesticide toxicity, pesticide signal words and type of pesticide formulations.
Formulation and Characterization of Biodegradable Medicated ...
African Journals Online (AJOL)
PEG)-600, tributyl citrate, PEG-200, PEG-300, PEG-400, PEG-4000, triethyl citrate and castor oil. The gum formulations were characterized for the following parameters: texture profile analysis (TPA), biodegradation, in vitro drug release using a ...
Algebraic formulation of higher gauge theory
Zucchini, Roberto
2017-06-01
In this paper, we present a purely algebraic formulation of higher gauge theory and gauged sigma models based on the abstract theory of graded commutative algebras and their morphisms. The formulation incorporates naturally Becchi - Rouet -Stora - Tyutin (BRST) symmetry and is also suitable for Alexandrov - Kontsevich - Schwartz-Zaboronsky (AKSZ) type constructions. It is also shown that for a full-fledged Batalin-Vilkovisky formulation including ghost degrees of freedom, higher gauge and gauged sigma model fields must be viewed as internal smooth functions on the shifted tangent bundle of a space-time manifold valued in a shifted L∞-algebroid encoding symmetry. The relationship to other formulations where the L∞-algebroid arises from a higher Lie groupoid by Lie differentiation is highlighted.
Chemical-Based Formulation Design: Virtual Experimentation
DEFF Research Database (Denmark)
Conte, Elisa; Gani, Rafiqul
This paper presents a software, the virtual Product-Process Design laboratory (virtual PPD-lab) and the virtual experimental scenarios for design/verification of consumer oriented liquid formulated products where the software can be used. For example, the software can be employed for the design......, the additives and/or their mixtures (formulations). Therefore, the experimental resources can focus on a few candidate product formulations to find the best product. The virtual PPD-lab allows various options for experimentations related to design and/or verification of the product. For example, the selection...... design, model adaptation). All of the above helps to perform virtual experiments by blending chemicals together and observing their predicted behaviour. The paper will highlight the application of the virtual PPD-lab in the design and/or verification of different consumer products (paint formulation...
Concepts and formulations for spatial multibody dynamics
Flores, Paulo
2015-01-01
This book will be particularly useful to those interested in multibody simulation (MBS) and the formulation for the dynamics of spatial multibody systems. The main types of coordinates that can be used in the formulation of the equations of motion of constrained multibody systems are described. The multibody system, made of interconnected bodies that undergo large displacements and rotations, is fully defined. Readers will discover how Cartesian coordinates and Euler parameters are utilized and are the supporting structure for all methodologies and dynamic analysis, developed within the multibody systems methodologies. The work also covers the constraint equations associated with the basic kinematic joints, as well as those related to the constraints between two vectors. The formulation of multibody systems adopted here uses the generalized coordinates and the Newton-Euler approach to derive the equations of motion. This formulation results in the establishment of a mixed set of differential and algebraic equ...
The Boltzmann equation in the difference formulation
Energy Technology Data Exchange (ETDEWEB)
Szoke, Abraham [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Brooks III, Eugene D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
2015-05-06
First we recall the assumptions that are needed for the validity of the Boltzmann equation and for the validity of the compressible Euler equations. We then present the difference formulation of these equations and make a connection with the time-honored Chapman - Enskog expansion. We discuss the hydrodynamic limit and calculate the thermal conductivity of a monatomic gas, using a simplified approximation for the collision term. Our formulation is more consistent and simpler than the traditional derivation.
Preformulation and Formulation Investigational New Drugs
1990-07-01
AD-A252 024 CONTRACT NO: DAMD17-85-C-5003 TITLE: PREFORMULATION AND FORMULATION INVESTIGATIONAL NEW DRUGS PRINCIPAL INVESTIGATOR: Douglas R. Flanagan... PREFORMULATION AND FOMULATION INVESTIGATIONAL Contract No. NEW DRUGS DAMD17-85-C-5003 6. AUTHOR(S) 0603807A Douglas R. Flanagan, John L. Lach (deceased), and...RA V, 16. PRICE CODE formulation studies , clinical studies 17. SECURITY CLASSIFICATION 18. SECURITY CtASSIFICATION 19. SECURITY CLASSIFICATION 20
Note on the ideal frame formulation
Lara, Martin
2017-09-01
An implementation of the ideal frame formulation of perturbed Keplerian motion is presented which only requires the integration of a differential system of dimension 7, contrary to the 8 variables traditionally integrated with this approach. The new formulation is based on the integration of a scaled version of the Eulerian set of redundant parameters and slightly improves runtime performance with respect to the 8-dimensional case while retaining comparable accuracy.
An herbal formulation for hemorrhoids treatment
Directory of Open Access Journals (Sweden)
S. Dehdari
2017-11-01
Full Text Available Background and objectives: Hemorrhoids is the most painful rectal disease. Straining and pregnancy seem playing chief roles in the development of hemorrhoids. Symptoms of hemorrhoids may include bleeding, inflammation and pain. Despite current medical efforts, many discomforts of hemorrhoids have not been handled. The aim of the present study was to formulate and evaluate Itrifal-e muqil (IM tablet to achieve desired pharmaceutical properties. Method: Quality control tests of Allium ampeloperasum L, Commiphora mukul (Hook. ex Stocks Engl., Phyllanthus emblica L., Terminalia chebula Retz. and Terminalia bellerica Retz. were performed. Afterwards, different formulations were prepared and their physical properties were evaluated. Subsequently, the formulation was coated and its physicochemical characteristics were assessed. Result: All of the herbs demonstrated good results in quality control tests according to United State Pharmacopeia (USP. Formulation-1 that was completely prepared based on explained manufacturing process of IM in traditional medicine manuscripts did not show suitable pharmaceutical properties. Among different formulations, Formulation-3 that consisted of A. ampeloperasum, C. mukul, P. emblica, T. chebula and T. bellerica, displayed best outcomes through different tests. Conclusion: Modern pharmaceutical approaches can excellently be adapted for IM preparations.
Microbiological quality of pediatric oral liquid formulations
Directory of Open Access Journals (Sweden)
Maria Josep Cabañas Poy
2016-09-01
Full Text Available The oral administration of drugs to the pediatric population involves the extemporaneous preparation of liquid formulations. These formulations have studies on their physicochemical stability, but they often lack microbiological studies. The objective of this study is to check the microbiological quality of five oral liquid formulations prepared with different excipients, which represent five major combinations, in two conditions: kept unopened until the day of the test, and in a multi-dose vial opened daily. The formulations were prepared according to standard operating procedures. Half of each batch was packaged in vials that remained closed until the day of testing, and the other half in a single container which was opened daily. Both the vials and the containers had been previously sterilized. Microbiological tests were performed weekly during the first month of the study, and then every two weeks, until the expiration date. The microbiological quality of oral liquid formulations is determined by the Royal Spanish Pharmacopoeia. The conclusion was that none of the formulations prepared that were packaged in sterilized containers became contaminated, either in unopened vials or in multi-dose containers when they were opened daily
The coevent formulation of quantum theory
International Nuclear Information System (INIS)
Wallden, Petros
2013-01-01
Understanding quantum theory has been a subject of debate from its birth. Many different formulations and interpretations have been proposed. Here we examine a recent novel formulation, namely the coevents formulation. It is a histories formulation and has as starting point the Feynman path integral and the decoherence functional. The new ontology turns out to be that of a coarse-grained history. We start with a quantum measure defined on the space of histories, and the existence of zero covers rules out single-history as potential reality (the Kochen Specker theorem casted in histories form is a special case of a zero cover). We see that allowing coarse-grained histories as potential realities avoids the previous paradoxes, maintains deductive non-contextual logic (alas non-Boolean) and gives rise to a unique classical domain. Moreover, we can recover the probabilistic predictions of quantum theory with the use of the Cournot's principle. This formulation, being both a realist formulation and based on histories, is well suited conceptually for the purposes of quantum gravity and cosmology.
Development of lapachol topical formulation: anti-inflammatory study of a selected formulation.
Lira, Ana Amélia M; Sester, Elizângela A; Carvalho, André Luis M; Strattmann, Ruth R; Albuquerque, Miracy M; Wanderley, Almir G; Santana, Davi P
2008-01-01
This study aimed at developing a topical formulation of lapachol, a compound isolated from various Bignoniaceae species and at evaluating its topical anti-inflammatory activity. The influence of the pharmaceutical form and different types of emulsifiers was evaluated by in-vitro release studies. The formulations showing the highest release rate were selected and assessed trough skin permeation and retention experiments. It was observed that the gel formulation provided significantly higher permeation and retained amount (3.9-fold) of lapachol as compared to the gel-cream formulation. Antinociceptive and antiedematogenic activities of the most promising formulation were also evaluated. Lapachol gel reduced the increase in hind-paw volume induced by carrageenan injection and reduced nociception produced by acetic acid (0.8% in water, i.p.) when used topically. These results suggest that topical delivery of lapachol from gel formulations may be an effective medication for both dermal and subdermal injuries.
Directory of Open Access Journals (Sweden)
Šoltýsová I.
2016-12-01
Full Text Available Active ingredients in pharmaceuticals differ by their physico-chemical properties and their bioavailability therefore varies. The most frequently used and most convenient way of administration of medicines is oral, however many drugs are little soluble in water. Thus they are not sufficiently effective and suitable for such administration. For this reason a system of lipid based formulations (LBF was developed. Series of formulations were prepared and tested in water and biorelevant media. On the basis of selection criteria, there were selected formulations with the best emulsification potential, good dispersion in the environment and physical stability. Samples of structurally different drugs included in the Class II of the Biopharmaceutics classification system (BCS were obtained, namely Griseofulvin, Glibenclamide, Carbamazepine, Haloperidol, Itraconazol, Triclosan, Praziquantel and Rifaximin, for testing of maximal saturation in formulations prepared from commercially available excipients. Methods were developed for preparation of formulations, observation of emulsification and its description, determination of maximum solubility of drug samples in the respective formulation and subsequent analysis. Saturation of formulations with drugs showed that formulations 80 % XA and 20 % Xh, 35 % XF and 65 % Xh were best able to dissolve the drugs which supports the hypothesis that it is desirable to identify limited series of formulations which could be generally applied for this purpose.
International Nuclear Information System (INIS)
Millen, M.J.; Rafter, P.T.; Sowerby, B.D.; Rainbow, M.T.; Jelenich, L.
1990-01-01
A fast neutron and γ-ray transmission (FNGT) gauge has been used to determine the moisture content of lump coke on the conveyor belt supplying the No. 3 blast furnace at the BHP Newcastle Steelworks. The gauge was operated on-line over the period June 1988-March 1989. Gauge moisture was compared with laboratory moisture, based on 30 increment composite samples taken from the belt, and with moisture determined by a second FNGT gauge on one of the hoppers feeding the conveyor belt. The r.m.s. difference between conveyor gauge moisture and laboratory moisture was 0.24 wt% during the calibration period for two hopper flow on the belt, which is normal plant condition. The accuracy of the conveyor belt gauge was maintained to within 0.37 wt% moisture over the full period of the plant trial. (author)
International Nuclear Information System (INIS)
Williams, W.R.; Anderson, J.C.
1995-01-01
The transportation of UF 6 is subject to regulations requiring the evaluation of packaging under a sequence of hypothetical accident conditions including exposure to a 30-min 800 degree C (1475 degree F) fire [10 CFR 71.73(c)(3)]. An issue of continuing interest is whether bare cylinders can withstand such a fire without rupturing. To address this issue, a lumped parameter heat transfer/stress analysis model (6FIRE) has been developed to simulate heating to the point of rupture of a cylinder containing UF 6 when it is exposed to a fire. The model is described, then estimates of time to rupture are presented for various cylinder types, fire temperatures, and fill conditions. An assessment of the quantity of UF 6 released from containment after rupture is also presented. Further documentation of the model is referenced
International Nuclear Information System (INIS)
Belsher, J.D.; Meinert, F.L.
2009-01-01
This document presents the differences between two HLW glass formulation models (GFM): The 1996 GFM and 2009 GFM. A glass formulation model is a collection of glass property correlations and associated limits, as well as model validity and solubility constraints; it uses the pretreated HLW feed composition to predict the amount and composition of glass forming additives necessary to produce acceptable HLW glass. The 2009 GFM presented in this report was constructed as a nonlinear optimization calculation based on updated glass property data and solubility limits described in PNNL-18501 (2009). Key mission drivers such as the total mass of HLW glass and waste oxide loading are compared between the two glass formulation models. In addition, a sensitivity study was performed within the 2009 GFM to determine the effect of relaxing various constraints on the predicted mass of the HLW glass.
Shirbani, Meisam Moory; Shishesaz, Mohammad; Hajnayeb, Ali; Sedighi, Hamid Mohammad
2017-06-01
The objective of this paper is to present a coupled magneto-electro-mechanical (MEM) lumped parameter model for the response of the proposed magneto-electro-elastic (MEE) energy harvesting systems under base excitation. The proposed model can be used to create self-powering systems, which are not limited to a finite battery energy. As a novel approach, the MEE composites are used instead of the conventional piezoelectric materials in order to enhance the harvested electrical power. The considered structure consists of a MEE layer deposited on a layer of non-MEE material, in the framework of unimorph cantilever bars (longitudinal displacement) and beams (transverse displacement). To use the generated electrical potential, two electrodes are connected to the top and bottom surfaces of the MEE layer. Additionally, a stationary external coil is wrapped around the vibrating structure to induce a voltage in the coil by the magnetic field generated in the MEE layer. In order to simplify the design procedure of the proposed energy harvester and obtain closed form solutions, a lumped parameter model is prepared. As a first step in modeling process, the governing constitutive equations, Gauss's and Faraday's laws, are used to derive the coupled MEM differential equations. The derived equations are then solved analytically to obtain the dynamic behavior and the harvested voltages and powers of the proposed energy harvesting systems. Finally, the influences of the parameters that affect the performance of the MEE energy harvesters such as excitation frequency, external resistive loads and number of coil turns are discussed in detail. The results clearly show the benefit of the coil circuit implementation, whereby significant increases in the total useful harvested power as much as 38% and 36% are obtained for the beam and bar systems, respectively.
Self-Setting Calcium Orthophosphate Formulations
Dorozhkin, Sergey V.
2013-01-01
In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoconductive, self-setting calcium orthophosphate formulations appear to be promising bioceramics for bone grafting. Furthermore, such formulations possess excellent molding capabilities, easy manipulation and nearly perfect adaptation to the complex shapes of bone defects, followed by gradual bioresorption and new bone formation. In addition, reinforced formulations have been introduced, which might be described as calcium orthophosphate concretes. The discovery of self-setting properties opened up a new era in the medical application of calcium orthophosphates and many commercial trademarks have been introduced as a result. Currently such formulations are widely used as synthetic bone grafts, with several advantages, such as pourability and injectability. Moreover, their low-temperature setting reactions and intrinsic porosity allow loading by drugs, biomolecules and even cells for tissue engineering purposes. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent bioceramics suitable for both dental and bone grafting applications, has been provided. PMID:24956191
Bioequivalence assessment of two formulations of ibuprofen
Al-Talla, Zeyad
2011-10-19
Background: This study assessed the relative bioavailability of two formulations of ibuprofen. The first formulation was Doloraz , produced by Al-Razi Pharmaceutical Company, Amman, Jordan. The second forumulation was Brufen , manufactured by Boots Company, Nottingham, UK. Methods and results: A prestudy validation of ibuprofen demonstrated long-term stability, freeze-thaw stability, precision, and accuracy. Twenty-four healthy volunteers were enrolled in this study. After overnight fasting, the two formulations (test and reference) of ibuprofen (100 mg ibuprofen/5 mL suspension) were administered as a single dose on two treatment days separated by a one-week washout period. After dosing, serial blood samples were drawn for a period of 14 hours. Serum harvested from the blood samples was analyzed for the presence of ibuprofen by high-pressure liquid chromatography with ultraviolet detection. Pharmacokinetic parameters were determined from serum concentrations for both formulations. The 90% confidence intervals of the ln-transformed test/reference treatment ratios for peak plasma concentration and area under the concentration-time curve (AUC) parameters were found to be within the predetermined acceptable interval of 80%-125% set by the US Food and Drug Administration. Conclusion: Analysis of variance for peak plasma concentrations and AUC parameters showed no significant difference between the two formulations and, therefore, Doloraz was considered bioequivalent to Brufen. 2011 Al-Talla et al, publisher and licensee Dove Medical Press Ltd.
A novel molluscicidal formulation of niclosamide.
Dai, Jian-Rong; Wang, Wei; Liang, You-Sheng; Li, Hong-Jun; Guan, Xiao-Hong; Zhu, Yin-Chang
2008-07-01
Snail control by molluscicides is an important strategy for schistosomiasis control in China. Currently, only one chemical molluscicide, niclosamide, which is used as 50% wettable powder of niclosamide ethanolamine salt (WPN), is commercially available for field snail control in China. However, WPN is costly, toxic, and has a lower dispersibility and precipitates rapidly. In this paper, we describe the development of a novel formulation of niclosamide, a suspension concentrate of niclosamide (SCN). The efficacy of SCN was evaluated both in the laboratory and field. SCN showed better molluscicidal effects than conventional formulation of WPN, as determined by LC(50) for adult snails, young snails, and snail eggs. The acute toxicity of SCN to Brachdanio rerio hamiton was less than WPN. In conclusion, the novel formulation of SCN suspension is physically more stable, more effective, and less toxic. Therefore, it can be more useful for controlling snails in endemic areas of schistosomiasis in China.
Engaged Problem Formulation in IS Research
DEFF Research Database (Denmark)
Nielsen, Peter Axel; Persson, John Stouby
2016-01-01
problems requires a more substantial engagement with the different stakeholders, especially when their problems are ill structured and situated in complex organizational settings. On this basis, we present an engaged approach to formulating IS problems with, not for, IS practitioners. We have come...... to understand engaged problem formulation as joint researching and as the defining of contemporary and complex problems by researchers and those practitioners who experience and know these problems. We used this approach in investigating IS management in Danish municipalities. In this paper, we present...... the approach to formulating problems in an engaged way. We discuss it in relation to ideas and assumptions that underpin engaged scholarship, and we discuss the implications for IS action research, design science research, and mixed approaches....
Engaged Problem Formulation in IS Research
DEFF Research Database (Denmark)
Nielsen, Peter Axel; Persson, John Stouby
2016-01-01
“Is this the problem?”: the question that haunts many information systems (IS) researchers when they pursue work relevant to both practice and research. Nevertheless, a deliberate answer to this question requires more than simply asking the involved IS practitioners. Deliberately formulating prob...... the approach to formulating problems in an engaged way. We discuss it in relation to ideas and assumptions that underpin engaged scholarship, and we discuss the implications for IS action research, design science research, and mixed approaches....... to understand engaged problem formulation as joint researching and as the defining of contemporary and complex problems by researchers and those practitioners who experience and know these problems. We used this approach in investigating IS management in Danish municipalities. In this paper, we present...
RAACFDb: Rheumatoid arthritis ayurvedic classical formulations database.
Mohamed Thoufic Ali, A M; Agrawal, Aakash; Sajitha Lulu, S; Mohana Priya, A; Vino, S
2017-02-02
In the past years, the treatment of rheumatoid arthritis (RA) has undergone remarkable changes in all therapeutic modes. The present newfangled care in clinical research is to determine and to pick a new track for better treatment options for RA. Recent ethnopharmacological investigations revealed that traditional herbal remedies are the most preferred modality of complementary and alternative medicine (CAM). However, several ayurvedic modes of treatments and formulations for RA are not much studied and documented from Indian traditional system of medicine. Therefore, this directed us to develop an integrated database, RAACFDb (acronym: Rheumatoid Arthritis Ayurvedic Classical Formulations Database) by consolidating data from the repository of Vedic Samhita - The Ayurveda to retrieve the available formulations information easily. Literature data was gathered using several search engines and from ayurvedic practitioners for loading information in the database. In order to represent the collected information about classical ayurvedic formulations, an integrated database is constructed and implemented on a MySQL and PHP back-end. The database is supported by describing all the ayurvedic classical formulations for the treatment rheumatoid arthritis. It includes composition, usage, plant parts used, active ingredients present in the composition and their structures. The prime objective is to locate ayurvedic formulations proven to be quite successful and highly effective among the patients with reduced side effects. The database (freely available at www.beta.vit.ac.in/raacfdb/index.html) hopefully enables easy access for clinical researchers and students to discover novel leads with reduced side effects. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
Directory of Open Access Journals (Sweden)
Farnaz Monajjemzadeh
2014-12-01
Full Text Available Purpose: In this research the effect of vitamin B1 and B6 on cyanocobalamin stability in commercial light protected parenteral formulations and upon adding stabilizing agents will be investigated and best formulation composition and proper storage condition will be introduced. Methods: In this research some additives such as co solvents and tonicity adjusters, surfactants, antioxidants and chelating agents as well as buffer solutions, were used to improve the stability of the parenteral mixed formulations of B12 in the presence of other B vitamins (B1 and B6. Screening tests and accelerated stability tests were performed according to ICH guidelines Q1A (R2. Results: Shelf life evaluation revealed the best formulation and the proper storage condition. The results indicated the first kinetic models for all tested formulations and the optimum pH value was determined to be 5.8. There was no evidence of B12 loss when mixed with B1 and B6 in a medical syringe at room temperature for maximum of 8 hours. Conclusion: It is necessary to formulate vitamin B12 mixed parenteral solutions using proper phosphate buffers (pH=5.8 and to indicate “Store in refrigerator” on the mixed parenteral formulations of vitamin B12 with other B vitamins, which has not been expressed on the label of tested Brand formulations at the time of this study.
Formulation and stability testing of photolabile drugs.
Tønnesen, H H
2001-08-28
Exposure of a drug to irradiation can influence the stability of the formulation, leading to changes in the physicochemical properties of the product. The influence of excipients of frequently used stabilizers is often difficult to predict and, therefore, stability testing of the final preparation is important. The selection of a protective packaging must be based on knowledge about the wavelength causing the instability. Details on drug photoreactivity will also be helpful in order to minimize side-effects and/or optimize drug targeting by developing photoresponsive drug delivery systems. This review focuses on practical problems related to formulation and stability testing of photolabile drugs.
Quaternionic formulation of the exact parity model
International Nuclear Information System (INIS)
Brumby, S.P.; Foot, R.; Volkas, R.R.
1996-01-01
The exact parity model (EPM) is a simple extension of the standard model which reinstates parity invariance as an unbroken symmetry of nature. The mirror matter sector of the model can interact with ordinary matter through gauge boson mixing, Higgs boson mixing and, if neutrinos are massive, through neutrino mixing. The last effect has experimental support through the observed solar and atmospheric neutrino anomalies. In the paper it is shown that the exact parity model can be formulated in a quaternionic framework. This suggests that the idea of mirror matter and exact parity may have profound implications for the mathematical formulation of quantum theory. 13 refs
Pharmacokinetics of formulated tenoxicam transdermal delivery systems.
Kim, Taekyung; Kang, Eunyoung; Chun, Inkoo; Gwak, Hyesun
2008-01-01
To investigate the feasibility of developing a new tenoxicam transdermal delivery system (TDS), the pharmacokinetics of tenoxicam from various formulated TDS were evaluated and compared with values following oral administration of tenoxicam and with application of a piroxicam plaster (Trast) marketed in Korea. Based on previous in-vitro study results, a mixture of diethylene glycol monoethyl ether (DGME) and propylene glycol monolaurate (PGML) (40:60) was used as a vehicle, and caprylic acid, capric acid, lauric acid, oleic acid or linoleic acid (each at 3%) was added as an enhancer. Triethanolamine (5%) was used as a solubilizer, and Duro-Tak 87-2510 as a pressure-sensitive adhesive. Among these fatty acids used for the formulation of tenoxicam TDS, caprylic acid showed the greatest enhancing effect; the area under the plasma concentration-time profile (AUC) decreased in the order of caprylic acid>linoleic acid>or=oleic acid>lauric acid>capric acid. Compared with oral administration, maximum plasma concentration (Cmax) was significantly lower, and time to reach Cmax (Tmax) delayed with all formulated tenoxicam TDS. All formulated TDS resulted in a lower AUC than with the oral formulation, except for TDS containing caprylic acid, although the difference was statistically significant only with capric acid. The AUC for all the formulated tenoxicam TDS was significantly higher than that of the piroxicam plaster; TDS with caprylic acid increased AUC 8.53-fold compared with the piroxicam plaster. Even though the Tmax of tenoxicam TDS was not significantly different from that of the piroxicam plaster, Cmax was higher; formulations containing caprylic acid and linoleic acid increased Cmax by 7.39- and 8.76-fold, respectively. In conclusion, a formulation containing 1.5 mL DGME-PGML (40:60) with 3% caprylic acid and 5% triethanolamine mixed with 6 g Duro-Tak 87-2510 could be a good candidate for developing a new tenoxicam TDS to maintain a comparable extent of absorption
Design of formulated products: a systematic methodology
DEFF Research Database (Denmark)
Conte, Elisa; Gani, Rafiqul; Ng, K.M.
2011-01-01
-based computer-aided methodology for design and verification of a class of chemical-based products (liquid formulations) is presented. This methodology is part of an integrated three-stage approach for design/verification of liquid formulations where stage-1 generates a list of feasible product candidates and....../or verifies a specified set through a sequence of predefined activities (work-flow). Stage-2 and stage-3 (not presented here) deal with the planning and execution of experiments, for product validation. Four case studies have been developed to test the methodology. The computer-aided design (stage-1...
Boundary layer computations using a generalized formulation
Bergeron, D.; Zingg, D. W.
A numerical solution procedure for a generalized form of the boundary-layer equations based on the formulation of Steger and Van Dalsem is described. The formulation, which is intended for use in a fortified Navier-Stokes procedure, uses the boundary-layer equations expressed in body-confromal coordinates but transformed into generalized coordinates for the solution process. Results are presented for attached and separated transonic airfoil flows with external pressure gradient given from a Navier-Stokes solution in the boundary layers. Discrepancies are noted near shocks and trailing edges, where normal pressure gradients can be appreciable and streamwise velocity gradients can be high.
Problem formulation as a discursive design activity
DEFF Research Database (Denmark)
Hansen, Claus Thorp; Dorst, Kees; Andreasen, Mogens Myrup
2009-01-01
part of any engineering design education. Yet the assumptions behind the rational problem solving approach to design do not sit well with some of the experiences we have in design teaching and design practice. Problem formulation is one such area where we might have to look for a different way...... the intricacies of problem formulation in design. Key notions in design methodology, like ‘design problem’, ‘design solution’ and ‘ill-structuredness’ are reconsidered in this light. This directly leads to identifying further lines for investigation, and an agenda for design research....
An exact approach for aggregated formulations
DEFF Research Database (Denmark)
Gamst, Mette; Spoorendonk, Simon
Aggregating formulations is a powerful approach for transforming problems into taking more tractable forms. Aggregated formulations can, though, have drawbacks: some information may get lost in the aggregation and { put in a branch-and-bound context { branching may become very di_cult and even....... The paper includes general considerations on types of problems for which the method is of particular interest. Furthermore, we prove the correctness of the procedure and consider how to include extensions such as cutting planes and advanced branching strategies....
Determination of carbamazepine in pharmaceutical formulations
Directory of Open Access Journals (Sweden)
Lílian Grace da Silva Solon
2010-09-01
Full Text Available The aim of this study was to evaluate the quality of five different solid formulations of carbamazepine. The reference formulation was Tegretol® 200.00 mg (Novartis and the others were: generic formulation of carbamazepine 200.00 mg (National Industry, similar formulation of carbamazepine 200.00 mg (National Industry, and two formulations of carbamazepine 200.00 mg acquired from two different compounding pharmacies. The latter consisted of capsules obtained in Natal, the capital city of the Brazilian State of Rio Grande do Norte. The quality of samples was evaluated through physical and physical-chemical tests, including: weight, diameter, thickness, content, dissolution, disintegration, hardness, friability and moisture. The results of friability analysis showed that all formulations met Brazilian and United States Pharmacopeia (USP specifications. In spite of having a higher hardness compared to the reference, the generic formulation had a lower disintegration time. This could be associated to the presence of crospovidone in its formulation. Results of this study showed that all formulations had dissolutions which were in accordance with Brazilian Pharmacopoeia specifications, and quality control tests. An exception was found for the similar formulation, which had a hardness parameter that exceeded the USP standard. However, this difference was not significant given the similar formulation's satisfactory disintegration time.O objetivo desse trabalho foi avaliar a qualidade de cinco formulações de carbamazepina na dosagem de 200,00 mg: medicamento referência Tegretol® (Novartis, medicamento genérico (indústria nacional, medicamento similar (indústria nacional e cápsulas do mesmo medicamento obtidas de duas farmácias de manipulação da cidade do Natal, RN. Os ensaios realizados foram: peso médio, diâmetro, espessura, teor, dissolução, desintegração, dureza, friabilidade e umidade. Foi observado que nenhuma das amostras
Lagrangian formulation of classical BMT-theory
International Nuclear Information System (INIS)
Pupasov-Maksimov, Andrey; Deriglazov, Alexei; Guzman, Walberto
2013-01-01
Full text: The most popular classical theory of electron has been formulated by Bargmann, Michel and Telegdi (BMT) in 1959. The BMT equations give classical relativistic description of a charged particle with spin and anomalous magnetic momentum moving in homogeneous electro-magnetic field. This allows to study spin dynamics of polarized beams in uniform fields. In particular, first experimental measurements of muon anomalous magnetic momentum were done using changing of helicity predicted by BMT equations. Surprisingly enough, a systematic formulation and the analysis of the BMT theory are absent in literature. In the present work we particularly fill this gap by deducing Lagrangian formulation (variational problem) for BMT equations. Various equivalent forms of Lagrangian will be discussed in details. An advantage of the obtained classical model is that the Lagrangian action describes a relativistic spinning particle without Grassmann variables, for both free and interacting cases. This implies also the possibility of canonical quantization. In the interacting case, an arbitrary electromagnetic background may be considered, which generalizes the BMT theory formulated to the case of homogeneous fields. The classical model has two local symmetries, which gives an interesting example of constrained classical dynamics. It is surprising, that the case of vanishing anomalous part of the magnetic momentum is naturally highlighted in our construction. (author)
Clinical pharmacology of novel anticancer drug formulations
Stuurman, F.E.
2013-01-01
Studies outlined in this thesis describe the impact of drug formulations on pharmacology of anticancer drugs. It consists of four parts and starts with a review describing the mechanisms of low oral bioavailability of anti-cancer drugs and strategies for improvement of the bioavailability. The
Formulation and characterization of caffeine biodegradable chewing ...
African Journals Online (AJOL)
) is a test for analysing the textural properties of food, in which the samples are ..... Food Technol 1978;. 32: 62-66. 16. Mehta FM, Trivedi P. Formulation and characterization of biodegradable medicated chewing gum delivery system for motion ...
Formulation and evaluation and terbutaline sulphate and ...
African Journals Online (AJOL)
We report the use of low rugosity lactose, product of controlled crystallization of this carrier, in the formulation of terbutaline sulphate and beclomethasone dipropionate dry powder inhalers. The deposition patterns obtained with inhalation mixtures consisting of the modified lactose and each of the micronised drugs ...
Dynamic psychiatry and the psychodynamic formulation
African Journals Online (AJOL)
In her book 'An Unquiet Mind' the psychologist Kay Jamison gives a moving ... Department of Psychiatry, University of Pretoria, Weskoppies Hospital, Pretoria, South Africa. Abstract: This ... psychodynamic formulation is unfortunately seldom incorporated in the psychiatric presentation of patients; guidelines are therefore ...
Facile Colorimetric Determination of Duloxetine in Formulations ...
African Journals Online (AJOL)
... the determination of duloxetine hydrochloride (DX). Methods: Ion-pair spectrophotometric method was employed for the determination of duloxetine hydrochloride (DX) in bulk and pharmaceutical formulations using acidic dye methyl orange (MO) as ion-pairing agent at pH 4 (phthalate buffer). The yellow ion-pair complex ...
Yang-Mills formulation of interacting strings
International Nuclear Information System (INIS)
Chan Hongmo; Tsou Sheungtsun
1988-06-01
A suggestion that the theory of interacting open bosonic string be reformulated as a generalised Yang-Mills theory is further elucidated. Moreover, a serious reservation regarding the ordering of operators in the earlier 'proof' of equivalence between the new and standard formulations is now removed. (author)
State-Space Formulation for Circuit Analysis
Martinez-Marin, T.
2010-01-01
This paper presents a new state-space approach for temporal analysis of electrical circuits. The method systematically obtains the state-space formulation of nondegenerate linear networks without using concepts of topology. It employs nodal/mesh systematic analysis to reduce the number of undesired variables. This approach helps students to…
Formulation of statistical mechanics for chaotic systems
Indian Academy of Sciences (India)
Here, we again strengthen the idea of statistical mechanics of chaotic systems using Kinchin's formulation based on microcanonical ensemble [13]. Further, we extend the study to canonical ensemble of such a system and as an example, we consider QO and obtain various thermodynamic quantities and the results are.
Development and Evaluation of Topical Gabapentin Formulations
Directory of Open Access Journals (Sweden)
Christopher J. Martin
2017-08-01
Full Text Available Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hydrogels containing various permeation enhancers, and a range of proprietary bases including a compounded Lipoderm® formulation; furthermore microneedle facilitated delivery was used as a positive control. Critically, permeation of gabapentin across a human epidermal membrane in vitro was assessed using Franz-type diffusion cells. Subsequently this data was contextualised within the wider scope of the literature. Although reports of topical gabapentin delivery have been shown to vary, largely dependent upon the skin model used, this study demonstrated that 6% (w/w gabapentin 0.75% (w/w Carbopol® hydrogels containing 5% (w/w DMSO or 70% (w/w ethanol and a compounded 10% (w/w gabapentin Lipoderm® formulation were able to facilitate permeation of the molecule across human skin. Further pre-clinical and clinical studies are required to investigate the topical delivery performance and pharmacodynamic actions of prospective formulations.
Development and Evaluation of Topical Gabapentin Formulations
Alcock, Natalie; Hiom, Sarah; Birchall, James C.
2017-01-01
Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hydrogels containing various permeation enhancers, and a range of proprietary bases including a compounded Lipoderm® formulation; furthermore microneedle facilitated delivery was used as a positive control. Critically, permeation of gabapentin across a human epidermal membrane in vitro was assessed using Franz-type diffusion cells. Subsequently this data was contextualised within the wider scope of the literature. Although reports of topical gabapentin delivery have been shown to vary, largely dependent upon the skin model used, this study demonstrated that 6% (w/w) gabapentin 0.75% (w/w) Carbopol® hydrogels containing 5% (w/w) DMSO or 70% (w/w) ethanol and a compounded 10% (w/w) gabapentin Lipoderm® formulation were able to facilitate permeation of the molecule across human skin. Further pre-clinical and clinical studies are required to investigate the topical delivery performance and pharmacodynamic actions of prospective formulations. PMID:28867811
Kit systems for granulated decontamination formulations
Tucker, Mark D.
2010-07-06
A decontamination formulation and method of making that neutralizes the adverse health effects of both chemical and biological compounds, especially chemical warfare (CW) and biological warfare (BW) agents, and toxic industrial chemicals. The formulation provides solubilizing compounds that serve to effectively render the chemical and biological compounds, particularly CW and BW compounds, susceptible to attack, and at least one reactive compound that serves to attack (and detoxify or kill) the compound. The formulation includes at least one solubilizing agent, a reactive compound, a sorbent additive, and water. A highly adsorbent sorbent additive (e.g., amorphous silica, sorbitol, mannitol, etc.) is used to "dry out" one or more liquid ingredients into a dry, free-flowing powder that has an extended shelf life, and is more convenient to handle and mix in the field. The formulation can be pre-mixed and pre-packaged as a multi-part kit system, where one or more of the parts are packaged in a powdered, granulated form for ease of handling and mixing in the field.
Formulation of Sodium Alginate Nanospheres Containing ...
African Journals Online (AJOL)
Purpose: The aim of this work was to formulate sodium alginate nanospheres of amphotericin B by controlled gellification method and to evaluate the role of the nanospheres as a “passive carrier” in targeted antifungal therapy. Methods: Sodium alginate nanospheres of amphotericin B were prepared by controlled ...
Compounded laxative formulations for substituting phenolphthalein ...
African Journals Online (AJOL)
Dr Patrick O Erah
acid, PEG, and sugar derivatives such as lactose, glucose and sorbitol when granulated with water. Not withstanding these interactions, it was possible to compound simple capsule, tablet and even an effervescent tablet formulations containing sennosides A & B that complied with pharmacopeial specifications. However ...
Formulation of Thermosensitive Hydrogel Containing Cyclodextrin ...
African Journals Online (AJOL)
Formulation of Thermosensitive Hydrogel Containing Cyclodextrin for Controlled Drug Delivery of Camptothecin. ... Camptothecin (CPT) released from the hydrogel (TF8) over 8 h in pH 7.4 buffer ranged from 38.97 - 92.5 %, and varied according to the composition of the hydrogels. Release of camptothecin was lowest from ...
Screening of mucoadhesive vaginal gel formulations
Directory of Open Access Journals (Sweden)
Ana Ochoa Andrade
2014-12-01
Full Text Available Rational design of vaginal drug delivery formulations requires special attention to vehicle properties that optimize vaginal coating and retention. The aim of the present work was to perform a screening of mucoadhesive vaginal gels formulated with carbomer or carrageenan in binary combination with a second polymer (carbomer, guar or xanthan gum. The gels were characterised using in vitroadhesion, spreadability and leakage potential studies, as well as rheological measurements (stress and frequency sweep tests and the effect of dilution with simulated vaginal fluid (SVF on spreadability. Results were analysed using analysis of variance and multiple factor analysis. The combination of polymers enhanced adhesion of both primary gelling agents, carbomer and carrageenan. From the rheological point of view all formulations presented a similar behaviour, prevalently elastic and characterised by loss tangent values well below 1. No correlation between rheological and adhesion behaviour was found. Carbomer and carrageenan gels containing the highest percentage of xanthan gum displayed good in vitro mucoadhesion and spreadability, minimal leakage potential and high resistance to dilution. The positive results obtained with carrageenan-xanthan gum-based gels can encourage the use of natural biocompatible adjuvants in the composition of vaginal products, a formulation field that is currently under the synthetic domain.
Comparative evaluation of organic formulations of Pseudomonas ...
African Journals Online (AJOL)
Comparative evaluation of organic formulations of Pseudomonas fluorescens based biopesticides and their application in the management of bacterial wilt of brinjal ... Effective management of bacterial wilt of brinjal by P. fluorescens under local conditions signifies its potentiality and scope as a plant growth promoting ...
[Optimization of formulations for dietetic pastry products].
Villarroel, M; Uquiche, E; Brito, G; Cancino, M
2000-03-01
Optimized formulations of dietetic pastry products such as cake and sponge cake premixes were formulated using the surface response methodology. % Emulsifier agent and baking time were the selected independent variables for cake, as well as % emulsifier agent % chlorinated flour the variables selected for sponge cake. Three different level of each variable summing up thirteen experimental formulae of each product were assessed to optimize the variables that could have some influence in the sensory characteristics of these dietetic products. The total sensory quality was determined for both dietetic products using the composite scoring test and a panel of 18 trained judges. Looking at the contour graphic and considering economic aspects the best combination of variables for cake formulation was 2% emulsifier agent and 48 minutes for baking time, With respect to sponge cake, the best combination was 6% emulsifier agent and 48% chlorinated flour. Shelf life studies showed that both dietetic formulations remained stable during storage conditions of 75 days at 30 degrees C. During this period, significant differences in sensory characteristics were not found (p pastry products had good acceptability, and open up marketing opportunities for new products with potential health benefits to consumers.
Release Properties of Paracetamol Granulationa Formulated with ...
African Journals Online (AJOL)
Theobroma cacao gum, TCG was derived as a dry powder from fresh fruits of Theobroma cacao. Various granulations of paracetamol were prepared with TCG at the concentrations of 0.5 – 4% w/w. Similar formulations were prepared using sodium carboxymethyl cellulose, SCMC and acacia gums as standards. In each ...
Hepatoprotective activity of polyherbal formulation against carbon ...
African Journals Online (AJOL)
hope&shola
2010-12-06
Dec 6, 2010 ... The ethanloic extracts of the polyherbal medicinal plants (Asteracantha longifolia, Cyperus rotundus and Bryophyllum pinnatum) were evaluated for hepatoprotective activity in carbon tetrachloride induced liver damage in rats. The ethanolic extract of polyherbal formulation at 250 mg/kg b.w. exhibited a ...
Initial value formulation of higher derivative gravity
International Nuclear Information System (INIS)
Noakes, D.R.
1983-01-01
The initial value problem is considered for the conformally coupled scalar field and higher derivative gravity, by expressing the equations of each theory in harmonic coordinates. For each theory it is shown that the (vacuum) equations can take the form of a diagonal hyperbolic system with constraints on the initial data. Consequently these theories possess well-posed initial value formulations
Formulation of statistical mechanics for chaotic systems
Indian Academy of Sciences (India)
We formulate the statistical mechanics of chaotic system with few degrees of freedom and investigated the quartic oscillator system using microcanonical and canonical ensembles. Results of statistical mechanics are numerically verified by considering the dynamical evolution of quartic oscillator system with two degrees of ...
On fictitious domain formulations for Maxwell's equations
DEFF Research Database (Denmark)
Dahmen, W.; Jensen, Torben Klint; Urban, K.
2003-01-01
We consider fictitious domain-Lagrange multiplier formulations for variational problems in the space H(curl: Omega) derived from Maxwell's equations. Boundary conditions and the divergence constraint are imposed weakly by using Lagrange multipliers. Both the time dependent and time harmonic...
Efficacy of Three Disinfectant Formulations against Multidrug ...
African Journals Online (AJOL)
The current increase in the prevalence of nosocomial infections within the hospital environment despite adequate cleaning and disinfection can be said to be due to the following: (i) ineffectiveness of the various disinfectant formulations used in infection control on the various hospital equipments and wards; (ii) development ...
PERFORMANCE OF LOCALLY FORMULATED FEEDS FOR ...
African Journals Online (AJOL)
ACSS
Fisheries is an important food production sub-sector, providing almost 20% of the world's protein supply; however, the trend in fish production from capture fisheries has reached its limits due to overfishing. A study was conducted to evaluate the performance of two locally formulated feeds as possible replacements for an ...
Formulation and Characterization of Biodegradable Medicated ...
African Journals Online (AJOL)
(TPA), biodegradation, in vitro drug release using a modified chewing apparatus, and sensory properties. Result: Formulations code MCG-5 and MCG-9 which incorporated glyceryl triacetate and castor oil as plasticizers, respectively, showed a biodegradation score of 2 and 1, respectively, indicating significant.
Formulation of Bioadhesive Carbomer Gel Incorporating Drug ...
African Journals Online (AJOL)
Purpose: To formulate carbomer gel to localize and target drug action in periodontal pockets. Methods: Diclofenac sodium (DS, anti-inflammatory) and metronidazole hydrochloride (MH, antibacterial) were loaded in gelatin microspheres using glutaraldehyde cross-linking. The microspheres were evaluated for drug loading, ...
A parcel formulation for Hamiltonian layer models
Bokhove, Onno; Oliver, M.
Starting from the three-dimensional hydrostatic primitive equations, we derive Hamiltonian N-layer models with isentropic tropospheric and isentropic or isothermal stratospheric layers. Our construction employs a new parcel Hamiltonian formulation which describes the fluid as a continuum of
Application of UV Imaging in Formulation Development.
Sun, Yu; Østergaard, Jesper
2017-05-01
Efficient drug delivery is dependent on the drug substance dissolving in the body fluids, being released from dosage forms and transported to the site of action. A fundamental understanding of the interplay between the physicochemical properties of the active compound and pharmaceutical excipients defining formulation behavior after exposure to the aqueous environments and pharmaceutical performance is critical in pharmaceutical development, manufacturing and quality control of drugs. UV imaging has been explored as a tool for qualitative and quantitative characterization of drug dissolution and release with the characteristic feature of providing real-time visualization of the solution phase drug transport in the vicinity of the formulation. Events occurring during drug dissolution and release, such as polymer swelling, drug precipitation/recrystallization, or solvent-mediated phase transitions related to the structural properties of the drug substance or formulation can be monitored. UV imaging is a non-intrusive and simple-to-operate analytical technique which holds potential for providing a mechanistic foundation for formulation development. This review aims to cover applications of UV imaging in the early and late phase pharmaceutical development with a special focus on the relation between structural properties and performance. Potential areas of future advancement and application are also discussed.
Formulation and Release Characteristics of Zidovudine- Loaded ...
African Journals Online (AJOL)
novel microencapsulating material for ibuprofen and diltiazem hydrochloride. Indian J. Pharm. Sci. 2007; 67: 263–268. 15. Doktorovova S, Souto EB. Nanostructured lipid carrier- based hydrogel formulations for drug delivery: A comprehensive review. Expert Opin Drug Deliv. 2009; 6: 165–176. 16. Higuchi T. Mechanism of ...
Necessity of rethinking oral pediatric formulations
DEFF Research Database (Denmark)
Bar-Shalom, Daniel
2014-01-01
by all patient groups, is needed, and an automated compounding concept is proposed. The finishing of the formulation is done at the dispensing pharmacy using an automated process. The individual components (pudding-like carrier, microencapsulated drug, and the dispensing robot and its software...
Mathematical programming formulations for the examinations ...
African Journals Online (AJOL)
We formulate, test and compare three Integer Programming models. It is concluded that, although exact methods cannot give a solution to a real-size problem, these models give a good benchmark for testing the performance of other approaches. This paper also gives a direction for better exact models for the University of ...
Potentials of cellulosic wastes in media formulation
African Journals Online (AJOL)
AJB SERVER
2007-02-05
Feb 5, 2007 ... Potential use of cellulosic wastes as carbon and energy sources in selective media formulations was investigated. Two agar media, Czapek-Dox and Sabouraud's agar, were modified by substituting their carbon sources with cellulose, sawdust and sugarcane pulps. Then, two fungi; Aspergillus niger.
Depreter, Flore; Amighi, Karim
2010-11-01
The aim of this work was to develop highly dispersible and dry formulations of insulin for use in dry powder inhalers (DPIs) using high-pressure homogenisation (HPH) and spray-drying. Several formulations were evaluated, including formulations spray-dried without excipients and formulations coated with lipids. A physiological lipid composition based on a mixture of cholesterol and phospholipids was used to form the coating film around micronised drug particles. The production technique and excipients were chosen in order to limit the degradation of the active ingredient. The resulting powders exhibited a size and shape suitable for the deep lung deposition of drugs, and good aerodynamic features were obtained for the different formulations tested, with fine particle fractions between 46% and 63% vs. 11% for raw insulin powder. The presence of a lipid coating of up to 30% (w/w) did not significantly affect the aerodynamic behaviour, and the coated formulations also exhibited a decreased residual moisture content of between 2.3% and 3.7% vs. 4.8% for raw insulin, which should improve the long-term stability of the protein formulations. No degradation of the insulin molecule occurred during the HPH/spray-drying process, as it was shown using an HPLC method (insulin content between 98.4% and 100.5%), and the content in high molecular weight proteins, assessed using a gel filtration method, stayed below 0.4%. Copyright © 2010 Elsevier B.V. All rights reserved.
Badyda, Artur J; Widziewicz, Kamila; Rogula-Kozłowska, Wioletta; Majewski, Grzegorz; Jureczko, Izabela
2018-01-01
The present study seeks to define the possible cancer risk arising from the inhalation exposure to particle (PM)-bound polycyclic aromatic hydrocarbons (PAHs) present in barbecue emission gases and to compare the risk depending on the type of fuel used for grill powering. Three types of fuel were compared: liquid propane gas, lump charcoal, and charcoal briquettes. PM 2.5 and PM 2.5-100 were collected during grilling. Subsequently, 16 PAHs congeners were extracted from the PM samples and measured quantitatively using gas chromatography. The content of PM-bound PAHs was used to calculate PAHs deposition in the respiratory tract using the multiple path particle dosimetry model. Finally, a probabilistic risk model was developed to assess the incremental lifetime cancer risk (ILCR) faced by people exposed to PAHs. We found a distinctly greater PAHs formation in case of grills powered by charcoal briquettes. The summary concentration of PAHs (Σ16PAH) ranged from briquettes). Daily exposure of a grill operator, while grilling meat, to PM 2.5 -bound PAHs, adjusted to benzo[a]pyrene toxicity equivalent (BaP eq ), was 326.9, 401.6, and 0.04 ng/d for lump charcoal, charcoal briquettes, and gas powered grill, respectively. Exposure to PAHs emitted from charcoal briquettes was four orders of magnitude greater than that for gas grill. The ILCR followed a log-normal distribution, with a geometric mean of 8.38 × 10 -5 for exposure to PM 2.5 -bound PAHs emitted from gas grills unloaded with food and as high as 8.68 × 10 -1 for the grills loaded with food over charcoal briquettes. The estimated cancer risk for people who would inhale barbecue particles for 5 h a day, 40 days a year exceeds the acceptable level set by the U.S. Environmental Protection Agency. We conclude that the type of heat source used for grilling influences the PM-bound PAHs formation. The greatest concentration of PAHs is generated when grilling over charcoal briquettes. Loading grills with food generates
CSIR Research Space (South Africa)
Katata, L
2012-10-01
Full Text Available statistical design with an L8 orthogonal array, was implemented to optimise the formulation parameters of PCL-EFV nanoparticles. The types of sugar (lactose or trehalose), surfactant concentration and solvent (dichloromethane and ethyl acetate) were chosen...
Directory of Open Access Journals (Sweden)
M. Gharavi
1990-07-01
Full Text Available In this study a pine tar shampoo as a new antidandruff formulation is presented. Assessment of antidandruff preparations has been hampered by the lack of standardized schedules, and reliable methods of evaluation.Some antidandruff agents such as : Zinc pyri-thione pine tar, selenium sulphide and (sulfure were used in shampoos. Samples were coded as numbers 1,2 formulated by us and 3,4 formulated commercially. The grading scheme based on 10 point scale, and corneocyte count was carried out on 50 selected volunte¬ers. Corneocyte count and fungal study proved that pine tor shampoo is effective against pityrosporum ovale. Draize lest was used for determination of the irritancy potential of the samples. Results showed that samples numbered 1,2 were relatively innocous in comparison with the others. I urthermore,s kin sensitination test on rabbit also confirmed the results obtained by Draize test. Consumer judgments proved that all formulations were acceptable.
Formulation of diclofenac for dermal delivery.
Goh, Choon Fu; Lane, Majella E
2014-10-01
Diclofenac (DF) was first synthesized in the 1960's and is currently available as ophthalmic, oral, parenteral, rectal and skin preparations. This review focuses on the administration of DF to the skin. As a member of the non-steroidal anti-inflammatory (NSAID) group of drugs the primary indications of DF are for the management of inflammation and pain but it is also used to treat actinic keratosis. The specific aims of this paper are to: (i) provide an overview of the pharmacokinetics and metabolism of DF following oral and topical administration; (ii) examine critically the various formulation approaches which have been investigated to enhance dermal delivery of DF; and (iii) identify new formulation strategies for enhanced DF skin penetration. Copyright © 2014 Elsevier B.V. All rights reserved.
Principles of ration formulation for ruminants
International Nuclear Information System (INIS)
Jayasuriya, M.C.N.
2002-01-01
Feeding standards as practiced in developed countries could be misleading when non-conventional feed resources are used in formulating rations for ruminant livestock in developing countries. They tend to reject the poor quality feeds that are available in vast quantities. The non-availability of good quality forage throughout the year and the need to optimise the efficiency of utilisation of locally available feed resources have lead to the application of basic nutritional principles when considering ration formulation. The alternative approach to the use of feeding standards would be to ensure that the production system matches the available resources. The development of feed supplementation strategies based on locally available feed resources require the understanding of the relative roles and nutrient needs of the two-compartment system represented by the micro-organisms in the rumen and the host animal. (author)
A FDM anisotropic formulation for EEG simulation.
Bruno, P; Hyttinen, J; Inchingolo, P; Magrofuoco, A; Mininel, S; Vatta, F
2006-01-01
Accurate head modeling is required to properly simulate bioelectric phenomena in 3-D as well as to estimate the 3-D bioelectric activity starting from superficial bioelectric measurements and 3-D imaging. Aiming to build an accurate and realistic representation of the volume conductor of the head, also the anisotropy of head tissues should be taken into account. In this paper we describe a new finite-difference method (FDM) formulation which accounts for anisotropy of the various head tissues. Our proposal, being based on FDM, derives the head model directly from patient's specific clinical images. We present here the details of the numerical formulation and the method validation by comparing our numerical proposal and known analytical results using a multi-shell anisotropic head model with skull anisotropy. Furthermore, we analyzed also different numerical grid refinement and EEG source characteristics. The comparison with previously developed FDM methods shows a good performance of the proposed method.
Application of UV Imaging in Formulation Development
DEFF Research Database (Denmark)
Sun, Yu; Østergaard, Jesper
2017-01-01
Efficient drug delivery is dependent on the drug substance dissolving in the body fluids, being released from dosage forms and transported to the site of action. A fundamental understanding of the interplay between the physicochemical properties of the active compound and pharmaceutical excipients...... defining formulation behavior after exposure to the aqueous environments and pharmaceutical performance is critical in pharmaceutical development, manufacturing and quality control of drugs. UV imaging has been explored as a tool for qualitative and quantitative characterization of drug dissolution...... and release with the characteristic feature of providing real-time visualization of the solution phase drug transport in the vicinity of the formulation. Events occurring during drug dissolution and release, such as polymer swelling, drug precipitation/recrystallization, or solvent-mediated phase transitions...
Ising formulations of many NP problems
Lucas, Andrew
2014-02-01
We provide Ising formulations for many NP-complete and NP-hard problems, including all of Karp's 21 NP-complete problems. This collects and extends mappings to the Ising model from partitioning, covering and satisfiability. In each case, the required number of spins is at most cubic in the size of the problem. This work may be useful in designing adiabatic quantum optimization algorithms.
Improved formulation for Faraday rotation characterization
Tioh, Jin-Wei; Weber, Robert J.; Mina, Mani
2011-04-01
The analysis of complex structures consisting of fibers, films, birefringent, and magnetic materials is greatly aided by the availability of an analysis structure. Jones calculus is typically utilized in the course of such analyses. However, standard Jones calculus does not account for the effect of reflections. An improved formulation for the characterization of Faraday rotation that alleviates this shortcoming is reported here and is integral for the proper analysis of devices employing magneto-optic effects.
Policy formulation and enactment: Linked up thinking?
McLaren, Susan
2015-01-01
This chapter explores the challenges, issues and potential of Design and Technology Education as an active contributor in transformational change working towards a sustainable future. The focus is on the process of policy formulation, through translation, into practice and implementation in Design and Technology education in schools. Overall, the aim is to examine what is central to change, the key stakeholders, and what might be considered the inhibitors to enactment of policy and practice c...
Path Integral Formulation of Anomalous Diffusion Processes
Friedrich, Rudolf; Eule, Stephan
2011-01-01
We present the path integral formulation of a broad class of generalized diffusion processes. Employing the path integral we derive exact expressions for the path probability densities and joint probability distributions for the class of processes under consideration. We show that Continuous Time Random Walks (CTRWs) are included in our framework. A closed expression for the path probability distribution of CTRWs is found in terms of their waiting time distribution as the solution of a Dyson ...
Ising formulations of many NP problems
Directory of Open Access Journals (Sweden)
Andrew eLucas
2014-02-01
Full Text Available We provide Ising formulations for many NP-complete and NP-hard problems, including all of Karp's 21 NP-complete problems. This collects and extends mappings to the Ising model from partitioning, covering and satisfiability. In each case, the required number of spins is at most cubic in the size of the problem. This work may be useful in designing adiabatic quantum optimization algorithms.
Planar multibody dynamics formulation, programming and applications
Nikravesh, Parviz E
2007-01-01
Introduction Multibody Mechanical Systems Types of Analyses Methods of Formulation Computer Programming Application Examples Unit System Remarks Preliminaries Reference Axes Scalars and Vectors Matrices Vector, Array, and Matrix Differentiation Equations and Expressions Remarks Problems Fundamentals of Kinematics A Particle Kinematics of a Rigid Body Definitions Remarks Problems Fundamentals of Dynamics Newton's Laws of Motion Dynamics of a Body Force Elements Applied Forces Reaction Force Remarks Problems Point-Coordinates: Kinematics Multipoint
Archaeology: formulation of a Roman cosmetic.
Evershed, R P; Berstan, R; Grew, F; Copley, M S; Charmant, A J H; Barham, E; Mottram, H R; Brown, G
2004-11-04
The discovery of a small tin canister in London during archaeological excavations of a Roman temple precinct, dated to the middle of the second century AD, is a landmark in the study of this class of artefact. Such discoveries from the Roman world are rare and this is the only one to be found so far with its lid and contents--a whitish medicinal or cosmetic cream--providing a unique opportunity for us to study the ancient formulation.
Inhaled dry powder formulations for treating tuberculosis.
Das, Shyamal; Tucker, Ian; Stewart, Peter
2015-01-01
Tuberculosis is the second leading cause of death from infectious diseases. Although antitubercular drugs have been traditionally administered orally, there is a growing interest in delivering drugs via the pulmonary route using nebulisers or dry powder inhalers. Drugs in dry powder inhalers (DPI) are stable and DPI are user-friendly compared to nebulisation which is time consuming, inconvenient and inefficient and requires special equipment. For tuberculosis treatment, drugs should target alveolar macrophages that harbour microorganisms and/or maintain high drug concentration at the infection site in the lung. Drug particles include micro-particles or nanoparticles. Powders can be engineered by micronisation, crystallisation, spray drying, freeze drying and particle coating approaches. The formulation may contain single or combination drugs. This paper will provide an update on current status of TB, its pathogenesis, current treatment strategies, shortcomings of current oral or parenteral delivery strategies, pulmonary delivery devices, advantages of pulmonary delivery of powder formulations, formulation approaches and pharmacokinetic studies of pulmonary delivery of powders for inhalation.
Phytoconstituents as photoprotective novel cosmetic formulations.
Saraf, S; Kaur, C D
2010-01-01
Phytoconstituents are gaining popularity as ingredients in cosmetic formulations as they can protect the skin against exogenous and endogenous harmful agents and can help remedy many skin conditions. Exposure of skin to sunlight and other atmospheric conditions causes the production of reactive oxygen species, which can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system. Such injuries damage regulation pathways of skin and lead to photoaging and skin cancer development. The effects of aging include wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks. Herbal extracts act on these areas and produce healing, softening, rejuvenating, and sunscreen effects. We have selected a few photoprotective phytoconstituents, such as curcumin, resveratrol, tea polyphenols, silymarin, quercetin and ascorbic acid, and have discussed the considerations to be undertaken for the development of herbal cosmetic formulations that could reduce the occurrence of skin cancer and delay the process of photoaging. This article is aimed at providing specific and compiled knowledge for the successful preparation of photoprotective herbal cosmetic formulations.
What is Quantum Mechanics? A Minimal Formulation
Friedberg, R.; Hohenberg, P. C.
2018-03-01
This paper presents a minimal formulation of nonrelativistic quantum mechanics, by which is meant a formulation which describes the theory in a succinct, self-contained, clear, unambiguous and of course correct manner. The bulk of the presentation is the so-called "microscopic theory", applicable to any closed system S of arbitrary size N, using concepts referring to S alone, without resort to external apparatus or external agents. An example of a similar minimal microscopic theory is the standard formulation of classical mechanics, which serves as the template for a minimal quantum theory. The only substantive assumption required is the replacement of the classical Euclidean phase space by Hilbert space in the quantum case, with the attendant all-important phenomenon of quantum incompatibility. Two fundamental theorems of Hilbert space, the Kochen-Specker-Bell theorem and Gleason's theorem, then lead inevitably to the well-known Born probability rule. For both classical and quantum mechanics, questions of physical implementation and experimental verification of the predictions of the theories are the domain of the macroscopic theory, which is argued to be a special case or application of the more general microscopic theory.
Directory of Open Access Journals (Sweden)
Muhammad Ahsan
2015-07-01
Full Text Available Fluid catalytic cracking (FCC is an essential process for the conversion of gas oil to gasoline. This study is an effort to model the phenomenon numerically using commercial computational fluid dynamics (CFD software, heavy density catalyst and 4-lump kinetic model. Geometry, boundary conditions and dimensions of industrial riser for catalytic cracking unit are conferred for 2D simulation using commercial CFD code FLUENT 6.3. Continuity, momentum, energy and species transport equations, applicable to two phase solid and gas flow, are used to simulate the physical phenomenon as efficient as possible. This study implements and predicts the use of the granular Eulerian multiphase model with species transport. Time accurate transient problem is solved with the prediction of mass fraction profiles of gas oil, gasoline, light gas and coke. The output curves demonstrate the breaking of heavy hydrocarbon in the presence of catalyst. An approach proposed in this study shows good agreement with the experimental and numerical data available in the literature.
Energy Technology Data Exchange (ETDEWEB)
Carey, D.C.
1999-12-09
TURTLE is a computer program useful for determining many characteristics of a particle beam once an initial design has been achieved, Charged particle beams are usually designed by adjusting various beam line parameters to obtain desired values of certain elements of a transfer or beam matrix. Such beam line parameters may describe certain magnetic fields and their gradients, lengths and shapes of magnets, spacings between magnetic elements, or the initial beam accepted into the system. For such purposes one typically employs a matrix multiplication and fitting program such as TRANSPORT. TURTLE is designed to be used after TRANSPORT. For convenience of the user, the input formats of the two programs have been made compatible. The use of TURTLE should be restricted to beams with small phase space. The lumped element approximation, described below, precludes the inclusion of the effect of conventional local geometric aberrations (due to large phase space) or fourth and higher order. A reading of the discussion below will indicate clearly the exact uses and limitations of the approach taken in TURTLE.
International Nuclear Information System (INIS)
Carey, D.C.
1999-01-01
TURTLE is a computer program useful for determining many characteristics of a particle beam once an initial design has been achieved, Charged particle beams are usually designed by adjusting various beam line parameters to obtain desired values of certain elements of a transfer or beam matrix. Such beam line parameters may describe certain magnetic fields and their gradients, lengths and shapes of magnets, spacings between magnetic elements, or the initial beam accepted into the system. For such purposes one typically employs a matrix multiplication and fitting program such as TRANSPORT. TURTLE is designed to be used after TRANSPORT. For convenience of the user, the input formats of the two programs have been made compatible. The use of TURTLE should be restricted to beams with small phase space. The lumped element approximation, described below, precludes the inclusion of the effect of conventional local geometric aberrations (due to large phase space) or fourth and higher order. A reading of the discussion below will indicate clearly the exact uses and limitations of the approach taken in TURTLE
Mackenzie, S G; Leinonen, I; Ferguson, N; Kyriazakis, I
2016-05-28
The objective of this study was to develop a novel methodology that enables pig diets to be formulated explicitly for environmental impact objectives using a Life Cycle Assessment (LCA) approach. To achieve this, the following methodological issues had to be addressed: (1) account for environmental impacts caused by both ingredient choice and nutrient excretion, (2) formulate diets for multiple environmental impact objectives and (3) allow flexibility to identify the optimal nutritional composition for each environmental impact objective. An LCA model based on Canadian pig farms was integrated into a diet formulation tool to compare the use of different ingredients in Eastern and Western Canada. By allowing the feed energy content to vary, it was possible to identify the optimum energy density for different environmental impact objectives, while accounting for the expected effect of energy density on feed intake. A least-cost diet was compared with diets formulated to minimise the following objectives: non-renewable resource use, acidification potential, eutrophication potential, global warming potential and a combined environmental impact score (using these four categories). The resulting environmental impacts were compared using parallel Monte Carlo simulations to account for shared uncertainty. When optimising diets to minimise a single environmental impact category, reductions in the said category were observed in all cases. However, this was at the expense of increasing the impact in other categories and higher dietary costs. The methodology can identify nutritional strategies to minimise environmental impacts, such as increasing the nutritional density of the diets, compared with the least-cost formulation.
A weakly compressible formulation for modelling liquid-gas sloshing
CSIR Research Space (South Africa)
Heyns, Johan A
2012-09-01
Full Text Available , the implementation of a weakly compressible formulation which accounts for variations in the gas density is presented. With the aim of ensuring a computational efficient implementation of the proposed formulation, an implicit iterative GMRES solver with LU...
Formulation and Characterization of Glutaraldehyde Cross-Linked ...
African Journals Online (AJOL)
Purpose: To formulate biodegradable chitosan microspheres loaded with famotidine to overcome the poor bioavailability and frequent dose administration of the drug. Methods: Chitosan microspheres were prepared by simple emulsification technique based on glutaraldehyde crosslinking. Various process and formulation ...
Preparation and characterization of Slow Release Formulations of ...
African Journals Online (AJOL)
alginate beads and characterize the resulting slow release formulations (SRFs) using scanning electron microscopy (SEM), and Fourier Transform infrared spectroscopy (FTIR). Two sets of formulations were made by extrusion into 0.25 M calcium ...
Random path formulation of nonrelativistic quantum mechanics
International Nuclear Information System (INIS)
Roncadelli, M.
1993-01-01
Quantum amplitudes satisfy (almost) the same calculus that probabilities obey in the theory of classical stochastic diffusion processes. As a consequence of this structural analogy, a new formulation of (nonrelativistic) quantum mechanics naturally arises as the quantum counterpart of the Langevin description of (classical) stochastic diffusion processes. Quantum fluctuations are simulated here by a Fresnel white noise (FWN), which is a (real) white noise with imaginary diffusion constant, whose functional (pseudo) measure yields the amplitude distribution for its configurations. Central to this approach is the idea that classical dynamical trajectories in configuration space are perturbed by the FWN. Hence, a single (arbitrary) classical dynamical path gets replaced by a family of quantum random paths (QRPs) - one for each FWN sample - all originating from the same space-time point (x', t'). The QRPs are the basic objects of the present formulation and are given by a Langevin equation with the FWN, whose drift is controlled by a (arbitrary) solution to the classical Hamilton-Jacobi equation. So, our approach is manifestly based on classical dynamics. Now, a transition amplitude is associated with each QRP: it gives the amplitude that a particle starting from (x', t') will reach (x'', t'') by travelling just along the considered QRP. The quantum mechanical propagator (x'', t'' modul x', t') then emerges as the FWN average of the transition amplitude along a QRP. Thus, quantum mechanics looks like classical mechanics as perturbed by the FWN. The general structure of this formulation is discussed in detail, along with some practical and conceptual implications. (author). 14 refs
Canonical formulation of IIB D-branes
International Nuclear Information System (INIS)
Kamimura, K.
1998-01-01
We find Wess-Zumino actions for kappa invariant type IIB D-branes in explicit forms. A simple and compact expression is obtained by the use of spinor variables which are defined as power series of differential forms. Using the Wess-Zumino actions we develop the canonical formulation and find the complete set of the constraint equations for generic type IIB Dp-branes. The conserved global supersymmetry charges are determined and the algebra containing the central charges can be obtained explicitly. (orig.)
The Canvas model in project formulation
Ferreira-Herrera, Diana Carolina
2016-01-01
Purpose: The aim of this article is to determine the relevance of the Canvas methodology in project formulation through model characterization, thus answering the question: Is the Canvas methodology a relevant model for project management in an entrepreneurial context? Description: The Canvas model seeks to manage projects as business units. It is a model intended for emphasizing the entrepreneurial potential in project management. For this, texts and articles that have provided the basis for...
Gradient Elasticity Formulations for Micro/Nanoshells
Directory of Open Access Journals (Sweden)
Bohua Sun
2014-01-01
Full Text Available The focus of this paper is on illustrating how to extend the second author’s gradient theory of elasticity to shells. Three formulations are presented based on the implicit gradient elasticity constitutive relation 1 -ld2∇2σij=Cijkl(1-ls2∇2εkl and its two approximations 1+ls2∇2-ld2∇2σij=Cijklεkl and σij=Cijkl(1+ld2∇2-ls2∇2εkl.
A geometric formulation of exceptional field theory
Energy Technology Data Exchange (ETDEWEB)
Bosque, Pascal du [Arnold Sommerfeld Center for Theoretical Physics,Department für Physik, Ludwig-Maximilians-Universität München,Theresienstraße 37, 80333 München (Germany); Max-Planck-Institut für Physik, Werner-Heisenberg-Institut, Föhringer Ring 6, 80805 München (Germany); Hassler, Falk [Department of Physics and Astronomy, University of North Carolina, Phillips Hall, CB #3255, 120 E. Cameron Ave., Chapel Hill, NC 27599-3255 (United States); City University of New York, The Graduate Center, 365 Fifth Avenue, New York, NY 10016 (United States); Department of Physics, Columbia University, Pupin Hall, 550 West 120th St., New York, NY 10027 (United States); Lüst, Dieter [Arnold Sommerfeld Center for Theoretical Physics,Department für Physik, Ludwig-Maximilians-Universität München,Theresienstraße 37, 80333 München (Germany); Max-Planck-Institut für Physik, Werner-Heisenberg-Institut, Föhringer Ring 6, 80805 München (Germany); Malek, Emanuel [Arnold Sommerfeld Center for Theoretical Physics,Department für Physik, Ludwig-Maximilians-Universität München,Theresienstraße 37, 80333 München (Germany)
2017-03-01
We formulate the full bosonic SL(5) exceptional field theory in a coordinate-invariant manner. Thereby we interpret the 10-dimensional extended space as a manifold with SL(5)×ℝ{sup +}-structure. We show that the algebra of generalised diffeomorphisms closes subject to a set of closure constraints which are reminiscent of the quadratic and linear constraints of maximal seven-dimensional gauged supergravities, as well as the section condition. We construct an action for the full bosonic SL(5) exceptional field theory, even when the SL(5)×ℝ{sup +}-structure is not locally flat.
Problem formulation as a discursive design activity
DEFF Research Database (Denmark)
Hansen, Claus Thorp; Dorst, Kees; Andreasen, Mogens Myrup
2009-01-01
In the design methodology literature, design is often described as a rational problem solving process. This approach has been very successful; it has lead to the creation of design process models, tools, methods and techniques. Design methods teaching along these lines has become an indispensable...... part of any engineering design education. Yet the assumptions behind the rational problem solving approach to design do not sit well with some of the experiences we have in design teaching and design practice. Problem formulation is one such area where we might have to look for a different way...
Quality Evaluation of Pharmaceutical Formulations Containing Hydrochlorothiazide
Directory of Open Access Journals (Sweden)
Marcelo Antonio de Oliveira
2014-10-01
Full Text Available Hydrochlorothiazide is a diuretic used to treat hypertension that belongs to class IV of the Biopharmaceutics Classification System. The drug was evaluated by quality control, thermal characterization tests, and pharmaceutical formulation compatibility studies. It was concluded that the generic drug, Lab 2, was not a pharmaceutical equivalent. The compounded drugs, Lab 5 and Lab 6, produced unsatisfactory but expected results, since there is no requirement for dissolution and dissolution profile testing for the commercialization of these products. In a compatibility study, lactose and mannitol were shown to be incompatible with HCTZ, which may explain the lack of equivalence of the generic pharmaceutical product, associated with other situations.
Formulation and method for preparing gels comprising hydrous hafnium oxide
Collins, Jack L; Hunt, Rodney D; Montgomery, Frederick C
2013-08-06
Formulations useful for preparing hydrous hafnium oxide gels contain a metal salt including hafnium, an acid, an organic base, and a complexing agent. Methods for preparing gels containing hydrous hafnium oxide include heating a formulation to a temperature sufficient to induce gel formation, where the formulation contains a metal salt including hafnium, an acid, an organic base, and a complexing agent.
Formulation and Pharmacokinetic Evaluation of Controlled-Release ...
African Journals Online (AJOL)
A coating layer was then applied with a mixture of HPMC, ethylcellulose, shellac, and HPMC phthalate. The effect of several formulation variables on in vitro drug release was studied; furthermore, the drug release kinetics of the optimized formulation was evaluated. The in vivo pharmacokinetics of the optimized formulation ...
Formulation and Pharmacokinetic Evaluation of Controlled-Release ...
African Journals Online (AJOL)
mixture of HPMC, ethylcellulose, shellac, and HPMC phthalate. The effect of several formulation variables on in vitro drug release was studied; furthermore, the drug release kinetics of the optimized formulation was evaluated. The in vivo pharmacokinetics of the optimized formulation was compared with those of commercial ...
Studies on the antimicrobial properties of formulated creams and ...
African Journals Online (AJOL)
Their performances were compared with those of standard antiseptic creams and ointments. The results of agar diffusion studies on cream and ointment formulations revealed that the topical bases used to disperse the medicaments could significantly affect the antimicrobial effectiveness of the formulation. Formulations ...
21 CFR 864.2875 - Balanced salt solutions or formulations.
2010-04-01
... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Balanced salt solutions or formulations. 864.2875 Section 864.2875 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Balanced salt solutions or formulations. (a) Identification. A balanced salt solution or formulation is a...
Formulation and method for preparing gels comprising hydrous aluminum oxide
Collins, Jack L.
2014-06-17
Formulations useful for preparing hydrous aluminum oxide gels contain a metal salt including aluminum, an organic base, and a complexing agent. Methods for preparing gels containing hydrous aluminum oxide include heating a formulation to a temperature sufficient to induce gel formation, where the formulation contains a metal salt including aluminum, an organic base, and a complexing agent.
Herbal antihyperlipidemic formulation of cocoa tea: Preparation and ...
African Journals Online (AJOL)
Purpose: To prepare and characterize a formulation containing an ethanol extract of Camellia ptilophylla leaves (cocoa tea), with a focus on antihyperlipidemic and anti-obesity activities. Methods: An aloe vera–based formulation of an ethanol extract of cocoa tea (C. ptilophylla) was prepared. The formulation was given ...
Standardization Of A Siddha Formulation Amukkara Curanam By ...
African Journals Online (AJOL)
Amukkara curanam, a Siddha formulation, currently used in all types of gastric disorders, rheumatic pain, insomnia and sexual insufficiency, was investigated for the estimation of the marker compounds, withaferine A and piperine contents in a prepared standard formulation and a commercial formulation by using HPTLC ...
A displacement based FE formulation for steady state problems
Yu, Y.
2005-01-01
In this thesis a new displacement based formulation is developed for elasto-plastic deformations in steady state problems. In this formulation the displacements are the primary variables, which is in contrast to the more common formulations in terms of the velocities as the primary variables. In a
Nanoemulsion formulation of Abatacept for lupus nephritis therapy ...
African Journals Online (AJOL)
Purpose: To formulate a nanoemulsion preparation of abatacept and evaluate its treatment efficacy in a C57BL/6 J mouse model of lupus nephritis (LN). Methods: An abatacept nanoemulsion formulation was prepared using coarse homogenization followed by high-energy ultrasonication. The formulation was assessed for ...
Francés, Alain Pascal; Berhe, Ermias; Lubczynski, Maciek
2010-05-01
Numerical flow models are nowadays a powerful and widely used tool for groundwater management. Their reliability requires both an accurate physical representation of an aquifer system and appropriate boundary conditions. While the hydraulic parameters like hydraulic conductivity (K) and storativity (S) are spatially dependent and time invariant, groundwater fluxes such as recharge (R), evapotranspiration from groundwater (ETg) and groundwater inflow/outflow (Qgw) can vary in both space and time. Multiplicity of combinations between parameters and fluxes leads to a non-uniqueness of model solutions which limits their reliability and forecasting capability. We propose to constrain groundwater models at the catchment scale by the spatio-temporal assessment of fluxes in the unsaturated zone. Although the physically based models that involve the Darcy's law and the conservation of mass through the Richard's equation constitute the most appropriate tools for fluxes assessment in the unsaturated zone, they are computationally demanding and require a complex parameterization and boundary condition definition, which restricts their application to large and regional scales. We have thus chosen to develop and apply a lumped-parameter unsaturated zone model because it uses simplified representations of the physical processes and limits the number of parameters. We present in this study the development and application of a spatio-temporal recharge model (pyEARTH-2D) coupled with the numerical flow model MODFLOW at the catchment scale. pyEARTH-2D is a lumped-parameter distributed (grid-based) model that shares the same spatial discretization of the MODFLOW model for coupling purpose. pyEARTH-2D solves the water balance in the topsoil layer using linear relations between fluxes and soil moisture on a daily basis. The partitioning of rainfall is done by taking into consideration interception, evapotranspiration, percolation, soil moisture storage and surface storage and runoff
Formulation and characterisation of valsartan proniosomes
Directory of Open Access Journals (Sweden)
Rao Rekha
2011-04-01
Full Text Available Non-ionic surfactant vesicles of valsartan, an angiotensin II inhibitor, were prepared by coacervation phase separation method. The prepared systems were characterised for encapsulation efficiency, shape, size and in vitro drug release. Stability study was carried out to investigate the leaching of drug from the proniosomal system during storage. The results showed that valsartan in all the formulations was successfully entrapped and a substantial change in release rate and an alteration in the encapsulation efficiency of valsartan from proniosomes were observed upon varying the type of surfactant and cholesterol content. The encapsulation efficiency of proniosomes prepared with Span 60 was superior to that prepared with Span 40. A preparation with 9:2:9 ratio of Span 60, cholesterol and lecithin gave maximum encapsulation efficiency (71.50% and release results (Q24h= 75% as compared to other compositions. Proniosomal formulations showed fairly high retention of valsartan inside the vesicles at refrigerated temperature (4-8oC up to 1 month.
Stabilisation de la formule des traces tordue
Moeglin, Colette
2016-01-01
Ce travail en deux volumes donne la preuve de la stabilisation de la formule des trace tordue. Stabiliser la formule des traces tordue est la méthode la plus puissante connue actuellement pour comprendre l'action naturelle du groupe des points adéliques d'un groupe réductif, tordue par un automorphisme, sur les formes automorphes de carré intégrable de ce groupe. Cette compréhension se fait en réduisant le problème, suivant les idées de Langlands, à des groupes plus petits munis d'un certain nombre de données auxiliaires; c'est ce que l'on appelle les données endoscopiques. L'analogue non tordu a été résolu par J. Arthur et dans ce livre on suit la stratégie de celui-ci. Publier ce travail sous forme de livre permet de le rendre le plus complet possible. Les auteurs ont repris la théorie de l'endoscopie tordue développée par R. Kottwitz et D. Shelstad et par J.-P. Labesse. Ils donnent tous les arguments des démonstrations même si nombre d'entre eux se trouvent déjà dans les travaux d'Ar...
Projecting India's energy requirements for policy formulation
International Nuclear Information System (INIS)
Parikh, Kirit S.; Karandikar, Vivek; Rana, Ashish; Dani, Prasanna
2009-01-01
Energy policy has to have a long-term perspective. To formulate it one needs to know the contours of energy requirements and options. Different approaches have been followed in literature, each with their own problems. A top down econometric approach provides little guidance on policies, while a bottom up approval requires too much knowledge and too many assumptions. Using top-down econometric approach for aggregate overall benchmarking and a detailed activity analysis model, Integrated Energy System Model, for a few large sectors, provides a unique combination for easing the difficulties of policy formulation. The model is described in this paper. Eleven alternate scenarios are built, designed to map out extreme points of feasible options. Results show that even after employing all domestic energy resource to their full potential, there will be a continued rise of fossil fuel use, continued importance of coal, and continued rise of import dependence. Energy efficiency emerges as a major option with a potential to reduce energy requirement by as much as 17%. Scenario results point towards pushing for development of alternative sources. (author)
Convex Formulations of Learning from Crowds
Kajino, Hiroshi; Kashima, Hisashi
It has attracted considerable attention to use crowdsourcing services to collect a large amount of labeled data for machine learning, since crowdsourcing services allow one to ask the general public to label data at very low cost through the Internet. The use of crowdsourcing has introduced a new challenge in machine learning, that is, coping with low quality of crowd-generated data. There have been many recent attempts to address the quality problem of multiple labelers, however, there are two serious drawbacks in the existing approaches, that are, (i) non-convexity and (ii) task homogeneity. Most of the existing methods consider true labels as latent variables, which results in non-convex optimization problems. Also, the existing models assume only single homogeneous tasks, while in realistic situations, clients can offer multiple tasks to crowds and crowd workers can work on different tasks in parallel. In this paper, we propose a convex optimization formulation of learning from crowds by introducing personal models of individual crowds without estimating true labels. We further extend the proposed model to multi-task learning based on the resemblance between the proposed formulation and that for an existing multi-task learning model. We also devise efficient iterative methods for solving the convex optimization problems by exploiting conditional independence structures in multiple classifiers.
Lyoprotected nanosphere formulations for paclitaxel controlled delivery.
Musumeci, T; Vicari, L; Ventura, C A; Gulisano, M; Pignatello, R; Puglisi, G
2006-01-01
The preparation and technological characterization of nanosphere formulations (NS) containing the anticancer drug paclitaxel (PTX) are reported. Poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) nanospheres (NS) were prepared by a solvent displacement method. They showed a mean particle size in the range 150-300 nm, with a high homogeneity (polydispersity index < 0.3). For long term stability, NS require additional procedures, such as freeze-drying. In this study, the effect on NS particle size and surface charge of different lyoprotectants (mono- and disaccharides, polyalcohols, and hydroxypropyl-beta-cyclodextrin) at various concentrations was tested by means of light scattering size analysis. The formulations freeze-dried with the addition of 10% glucose (w/v) showed interesting characteristics after freeze-drying. They were chosen for specific studies on drug encapsulation efficiency, in vitro drug release and biological activity on the human anaplastic thyroid carcinoma cell line 8305C. The PLGA NS, in particular, showed a cell growth inhibitory activity comparable to the free drug.
Nimodipine Ophthalmic Formulations for Management of Glaucoma.
Maria, Doaa Nabih; Abd-Elgawad, Abd-Elgawad Helmy; Soliman, Osama Abd-Elazeem; El-Dahan, Marwa Salah; Jablonski, Monica M
2017-04-01
Preparation and evaluation of topical ophthalmic formulations containing nimodipine-CD complexes prepared using HP-β-CD, SBE-β-CD and M-β-CD for the management of glaucoma. Nimodipine-CD complexes were prepared using a freeze-drying method. Two different molar ratios (NMD:CD) were used for each cyclodextrin. The inclusion complexes were characterized using DSC, FTIR, yield (%), drug content and in vitro release characteristics. NMD-CD complexes incorporated into chitosan eye drops and a temperature-triggered in situ gelling system were evaluated for their pH, viscosity and in vitro release characteristics. We determined the intraocular pressure (IOP) lowering effect of NMD-hydroxypropylmethylcellulose (HPMC) eye drops through a single dose response design using C57BL/6J mice. The minimum effective concentration (MEC) of nimodipine was further applied to mice that vary in the parental allele of Cacna1s, the drug target of nimodipine. Cytotoxicity was also evaluated. Our ophthalmic formulations possessed pH and viscosity values that are compatible with the eye. In vitro release of nimodipine was significantly increased from chitosan eye drops containing NMD-CD complexes compared to uncomplexed drug. Administration of nimodipine can lower IOP significantly after a single drop of drug HPMC suspension. The IOP-lowering response of the MEC (0.6%) was significantly influenced by the parental allele of Cacna1s. Nimodipine can be used as a promising topical drug for management of glaucoma through ocular delivery.
Approaches to polymer selection for mascara formulation.
Loginova, Yelena; Shah, Vibha; Allen, Glenn; Macchio, Ralph; Farer, Alan
2009-01-01
The use of hair-care and hair-styling polymers in mascara formulation is well known. This paper introduces pre-formulative evaluation of film formers which are intended to be applied on eyelashes for mascara development to screen film formers more effectively. The film-forming characteristics of randomly selected hairstyling polymers were evaluated under the influence of pH, temperature, surfactant, and pigment dispersion. The selected polymers included acrylics, polyurethanes, and a pyrrolidone, all of which are used throughout the hair-care and mascara industries. An Erichsen Model 299/300 Pendulum Damping Tester was used to determine film hardness. In analyzing samples by the effect of temperature, the hardest neat polymer, a styrene-acrylate, softened 30% after heating. For most of the other polymers, the hardness was slightly lower compared to the neat polymer. The addition of pigment didn't significantly influence the hardness of one acrylic copolymer and a urethane dispersion, but most of the other polymers exhibited a reduction in film hardness. Various hardnesses were observed with different surfactants and different pH's.
Factors for formulating strategies for environmental restoration
International Nuclear Information System (INIS)
1998-07-01
This publication focusses on factors which are important for formulating a strategy for environmental restoration. In parallel to this effort, the IAEA has conducted activities in related areas which have been reported in companion reports dealing with (1) the characterization of radioactively contaminated sites for remediation purposes and (2) available technology for cleanup and remediation of radioactively contaminated sites. Additionally, follow-up activities will focus on two other areas, viz. planning and management options for cleanup of contaminated groundwater, and post-restoration monitoring of decommissioned sites. In a separate initiative the IAEA has developed preliminary guidance on radiological criteria for determining when cleanup action is needed and for deciding on when areas have been cleaned up to a sufficient extent. It is also concerned with radioactive contamination of soils, groundwaters, structures and biota which may have the potential for harm to people. It is intended that it will serve as an important source of information and data on the key factors to be considered in the formulation of an environmental restoration strategy
Leddy, Rebecca; Irshad, Abid; Zerwas, Emily; Mayes, Nicholas; Armeson, Kent; Abid, Maham; Cluver, Abbie; Campbell, Amy; Ackerman, Susan; Lewis, Madelene
2013-01-01
To determine if ultrasound and/or mammography is helpful in detecting breast cancers in patients presenting with focal breast pain. Patients who presented between February 2008 and April 2011 with focal breast pain without a lump were included in the study. The mammographic and US findings were retrospectively reviewed. BIRADS 0, 4, and 5 were considered positive on mammogram while BIRADS 4 and 5 were considered positive on US. The efficacy of mammogram-alone, ultrasound-alone, and in combination to detect breast cancer was evaluated. The performance of mammography for detecting any mass lesions that were present on subsequent US was also evaluated. A total of 257 patients were evaluated with US and 206 (80.1%) of these also had mammograms prior to the US. Cancer incidence was 1.2% (n = 3). The sensitivity, specificity, PPV, and NPV of mammogram-alone and US-alone for detection of breast cancer in these patients were 100%, 87.6%, 10.7%, 100% and 100%, 92.5%, 13.6%, and 100%, respectively, while for combined mammogram and US was 100%, 83.7%, 8.3%, and 100%. The sensitivity, specificity, PPV, and NPV of mammogram for identifying an underlying suspicious mass lesion that was subsequently detected by US was 58%, 91%, 39%, and 95%. The NPV of a BIRADS 1 mammogram for any underlying mass lesion was 75%. Addition of an ultrasound to a mammogram did not detect additional cancers; likely due to low cancer incidence in these patients. However, US detected underlying mass lesions in 25% cases with a BIRADS 1 mammogram result. © 2013 Wiley Periodicals, Inc.
Shirai, Atsushi; Suzuki, Takuya; Seki, Takashi
2015-09-01
The aim of this study was to develop a mathematical model of blood flow in the systemic circulation to emulate the change in hemodynamics by acupuncture therapy to elucidate the mechanism of the therapy. For this purpose, as a first step, a simple model of arterial blood flow was presented to reproduce previously reported change in the blood flow volume by the acupuncture needle stimulation of Taichong (LR-3). This model was based on the lumped-parameter approximation of arterial blood flow together with linear resistance of peripheral circulation. It has been reported that blood flow in the left arm was enhanced after the stimulation, yielding the peripheral vascular resistance-regulated blood flow dominated by the sympathetic nervous system. In addition to the peripheral resistance, another parameter that possibly regulates the blood flow is the cross-sectional area of the vessel. These two factors were changed to numerically examine their contributions to the blood flow based on the hypothesis that they could be changed by the stimulation. The numerical result was compared with the experimental result to confirm the validity of the hypothesis that the blood flow in the arm is regulated by the peripheral resistance. This model is extremely simple and the physical parameters introduced for the simulation were gleaned from different reports in the literature. It was demonstrated, however, that regulation of the peripheral resistance rather than of the cross-sectional area could reproduce the experimentally observed change in the blood flow. Moreover, the relationship between the changes in the flow volume and the systemic vascular resistance quantitatively matched the experimental data. The present model has a potential to emulate hemodynamic change by acupuncture therapy by incorporating physiological correlation of stimulation of an acupoint and regulation of parameters that affect the hemodynamics.
Engaged Problem Formulation of IT Management in Danish Municipalities
DEFF Research Database (Denmark)
Nielsen, Peter Axel; Persson, John Stouby
2012-01-01
relevant in contemporary municipal IT management practice. On this basis, we present an engaged scholarship approach to formulate IT management problems together with municipalities - not for municipalities. We have come to understand such engaged problem formulation as joint researching and defining...... of a contemporary and complex problem by researchers and those who experience and know the problem. We present the formulated IT management problems and discuss the engaged problem formulation process in relation to engaged scholarship. Furthermore, we discuss how engaged problem formulation may contribute...... to action research when making sense of ill-structured problems by involving multiple stakeholders....
Flow Formulations for Curriculum-based Course Timetabling
DEFF Research Database (Denmark)
Bagger, Niels-Christian Fink; Kristiansen, Simon; Sørensen, Matias
2017-01-01
In this paper we present two mixed-integer programming formulations for the Curriculum based Course Timetabling Problem (CTT). We show that the formulations contain underlying network structures by dividing the CTT into two separate models and then connect the two models using flow formulation...... techniques. The first mixed-integer programming formulation is based on an underlying minimum cost flow problem, which decreases the number of integer variables significantly and improves the performance compared to an intuitive mixed-integer programming formulation. The second formulation is based...... on a multi-commodity flow problem which in general is NP-hard, however, we prove that it suffices to solve the linear programming relaxation of the model. The formulations show competitiveness with other approaches based on mixed-integer programming from the literature and improve the currently best known...
Perturbation theory and importance functions in integral transport formulations
International Nuclear Information System (INIS)
Greenspan, E.
1976-01-01
Perturbation theory expressions for the static reactivity derived from the flux, collision density, birth-rate density, and fission-neutron density formulations of integral transport theory, and from the integro-differential formulation, are intercompared. The physical meaning and relation of the adjoint functions corresponding to each of the five formulations are established. It is found that the first-order approximation of the perturbation expressions depends on the transport theory formulation and on the adjoint function used. The approximations of the integro-differential formulation corresponding to different first-order approximations of the integral transport theory formulations are identified. It is found that the accuracy of all first-order approximations of the integral transport formulations examined is superior to the accuracy of first-order integro-differential perturbation theory
Determination of Fluoride in Different Toothpaste Formulations
International Nuclear Information System (INIS)
Kamau, N.G.; Njoroge, M.; Njau, M.
1998-01-01
Fluoride ion selective electrode was used to determine fluoride ion concentrations in seven brands of toothpaste. These were the only available formulations found in Kenya. The brands were classified into three groups-fluoridated, non fluoridated or not indicated. However, there was no independent indication of their quantitative composition. The analysed brands had fluoride content between 0.0033% and 0.096%. These values compared favourably with those obtained elsewhere. The calculated lowest limit of detection (LLD) was 0.01 ppmF- . The mean calibration curve gave a slope of of -50.0mV. which was not significantly different from the theoretical value of 5.88mV at 23 degrees celsius at 95% confidence level
Real symplectic formulation of local special geometry
Ferrara, Sergio; Ferrara, Sergio; Macia, Oscar
2006-01-01
We consider a formulation of local special geometry in terms of Darboux special coordinates $P^I=(p^i,q_i)$, $I=1,...,2n$. A general formula for the metric is obtained which is manifestly $\\mathbf{Sp}(2n,\\mathbb{R})$ covariant. Unlike the rigid case the metric is not given by the Hessian of the real function $S(P)$ which is the Legendre transform of the imaginary part of the holomorphic prepotential. Rather it is given by an expression that contains $S$, its Hessian and the conjugate momenta $S_I=\\frac{\\partial S}{\\partial P^I}$. Only in the one-dimensional case ($n=1$) is the real (two-dimensional) metric proportional to the Hessian with an appropriate conformal factor.
Formulation of similarity porous media systems
International Nuclear Information System (INIS)
Anderson, R.M.; Ford, W.T.; Ruttan, A.; Strauss, M.J.
1982-01-01
The mathematical formulation of the Porous Media System (PMS) describing two-phase, immiscible, compressible fluid flow in linear, homogeneous porous media is reviewed and expanded. It is shown that families of common vertex, coaxial parabolas and families of parallel lines are the only families of curves on which solutions of the PMS may be constant. A coordinate transformation is used to change the partial differential equations of the PMS to a system of ordinary differential equations, referred to as a similarity Porous Media System (SPMS), in which the independent variable denotes movement from curve to curve in a selected family of curves. Properties of solutions of the first boundary value problem are developed for the SPMS
Investigation of some topical formulations containing dexpanthenol.
Stozkowska, Wiesława; Piekoś, Ryszard
2004-01-01
Owing to its ability to regenerate epidermal cells Dexpanthenol (D-panthenol; chemically known as (+)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide) has found use for the treatment of patholytic ileus and postoperative distention. The purpose of research was to develop a gel containing dexpanthenol by monitoring the effect of various concentrations of a gelating agent on the activity of the ciliary apparatus. A system containing 2.5% of hydroxyethylcellulose was optimal for the preparation of the gel. Together with a formulation containing 5% of dexpanthenol, drops with equal concentration of the active compound were tested for comparison. Physical characteristics, such as osmotic pressure, acidity, density and viscosity of the preparation were determined as well as its microbiological sterility. The anti-inflammatory activity of the gel was determined following its topical application. Epidermal tests showed its good tolerance after topical application to the shaved skin of guinea pigs.
Grout formulations for nuclear-waste isolation
International Nuclear Information System (INIS)
Buck, A.D.; Mather, K.
1982-06-01
It is imperative that control parameters for a grout mixture such as flow time, setting time, compressive strength, permeability, or combinations of these or of other properties be specified before a grout mixture is formulated and used. Once such parameters have been specified, it is possible to proportion a hydraulic cement-based grout mixture to meet the applicable requirements. This may be from experience or by trial mixtures or by both. While longevity of cemetitious mixtures in nonaggressive environments is known from history, satisfactory data involving specific mixtures in selected environments are still needed. Such testing is underway. While compatibility, especially long-term compatibility, of cemetitious mixtures with various rock types is also known, it is necessary to have such evidence for specific mixtures in contact with specific rocks in a selected environment or environments. Satisfactory grout mixtures may be proportioned using the standard practice set forth in Appendix A
FORMATE-BASED FLUIDS: FORMULATION AND APPLICATION
Directory of Open Access Journals (Sweden)
Nediljka Gaurina-Međimurec
2008-12-01
Full Text Available Formate-based fluids has been successfully used in over hunders HPHT well operations since they introduced in field practice. They have many advantages when compared with conventional HPHT drilling and completion fluids such as: minimal formation damage, maintenance of additve properties at high temperatures, reduced hydraulic flow resistance, low potential for differential sticking, naturally lubricating, very low corrosion rates, biodegradable and pose little risk to the environment etc. Formate-based fluids can be applied during deep slim hole drilling, shale drilling, reservoir drilling, salt and gas hydrate formations drilling. The laboratory research was carried out to evaluate the rheological behavior of formate-based fluids as a function of temperature. Formate-based fluids were formulated using potassium formate brine, xanthan polymer, PAC, starch and calcium carbonate. Experimental results show that potassium formate improves the thermal stability of polymers.
Homogeneous catalyst formulations for methanol production
Mahajan, Devinder; Sapienza, Richard S.; Slegeir, William A.; O'Hare, Thomas E.
1990-01-01
There is disclosed synthesis of CH.sub.3 OH from carbon monoxide and hydrogen using an extremely active homogeneous catalyst for methanol synthesis directly from synthesis gas. The catalyst operates preferably between 100.degree.-150.degree. C. and preferably at 100-150 psia synthesis gas to produce methanol. Use can be made of syngas mixtures which contain considerable quantities of other gases, such as nitrogen, methane or excess hydrogen. The catalyst is composed of two components: (a) a transition metal carbonyl complex and (b) an alkoxide component. In the simplest formulation, component (a) is a complex of nickel tetracarbonyl and component (b) is methoxide (CH.sub.3 O.sup.13 ), both being dissolved in a methanol solvent system. The presence of a co-solvent such as p-dioxane, THF, polyalcohols, ethers, hydrocarbons, and crown ethers accelerates the methanol synthesis reaction.
An extended formulation of Maxwell's equations
International Nuclear Information System (INIS)
Lehnert, B.
1985-10-01
An extended Lorentz invariant formulation of Maxwell's equations is presented which both includes time dependent and steady-state solutions. In this approach the charge and current densities are treated as intrinsic properties of the electromagnetic field itself, in vacuo. Two main results follow from such an approach. First, a longitudinal electric wave is predicted to propagate in vacuo. Second, an axially symmetric steady state can be outlined in which 'self-confined' electromagnetic radiation circulates in closed orbits around the axis of symmetry. For this state values are obtained of the charge, the spin, and the product between magnetic moment and mass which are of the same order of magnitude as those observed for some elementary particles such as the proton and electron. Consequently, this may provide certain areas of conventional elementary particle analysis with some complementary ideas. Whether the predicted new phenomena also correspond to physical realities is so far an open question which requires further investigation. With 6 refs. (Author)
Peridynamic Formulation for Coupled Thermoelectric Phenomena
Directory of Open Access Journals (Sweden)
Migbar Assefa
2017-01-01
Full Text Available Modeling of heat and electrical current flow simultaneously in thermoelectric convertor using classical theories do not consider the influence of defects in the material. This is because traditional methods are developed based on partial differential equations (PDEs and lead to infinite fluxes at the discontinuities. The usual way of solving such PDEs is by using numerical technique, like Finite Element Method (FEM. Although FEM is robust and versatile, it is not suitable to model evolving discontinuities. To avoid such shortcomings, we propose the concept of peridynamic theory to derive the balance of energy and charge equations in the coupled thermoelectric phenomena. Therefore, this paper presents the transport of heat and charge in thermoelectric material in the framework of peridynamic (PD theory. To illustrate the reliability of the PD formulation, numerical examples are presented and results are compared with those from literature, analytical solutions, or finite element solutions.
Single-particle Schroedinger fluid. I. Formulation
International Nuclear Information System (INIS)
Kan, K.K.; Griffin, J.J.
1976-01-01
The problem of a single quantal particle moving in a time-dependent external potential well is formulated specifically to emphasize and develop the fluid dynamical aspects of the matter flow. This idealized problem, the single-particle Schroedinger fluid, is shown to exhibit already a remarkably rich variety of fluid dynamical features, including compressible flow and line vortices. It provides also a sufficient framework to encompass simultaneously various simplified fluidic models for nuclei which have earlier been postulated on an ad hoc basis, and to illuminate their underlying restrictions. Explicit solutions of the single-particle Schroedinger fluid problem are studied in the adiabatic limit for their mathematical and physical implications (especially regarding the collective kinetic energy). The basic generalizations for extension of the treatment to the many-body Schroedinger fluid are set forth
Nanoparticle formulations of cisplatin for cancer therapy
Duan, Xiaopin; He, Chunbai; Kron, Stephen J.; Lin, Wenbin
2016-01-01
The genotoxic agent cisplatin, used alone or in combination with radiation and/or other chemotherapeutic agents, is an important first-line chemotherapy for a broad range of cancers. The clinical utility of cisplatin is limited both by intrinsic and acquired resistance and dose-limiting normal tissue toxicity. That cisplatin shows little selectivity for tumor versus normal tissue may be a critical factor limiting its value. To overcome the low therapeutic ratio of the free drug, macromolecular, liposomal and nanoparticle drug delivery systems have been explored toward leveraging the enhanced permeability and retention (EPR) effect and promoting delivery of cisplatin to tumors. Here, we survey recent advances in nanoparticle formulations of cisplatin, focusing on agents that show promise in preclinical or clinical settings. PMID:26848041
Towards strategy formulation in a complex environment
Directory of Open Access Journals (Sweden)
René Pellissier
2014-01-01
Full Text Available The management sciences offer mainly linear solutions to an environment that is becoming increasingly complex. This is aggravated by the need for innovation outcomes. Formulating and implementing strategy is therefore far more complicated. Since developing economies face far less stable environments, businesses operating in these domains are more accustomed (even adept to deal with complexity. This article compares the deployment of complexity in strategy to achieve innovation in either a developing or a developed economy setting. From interviews conducted with selected CEOs from both economies, it was found that the businesses in the developing economies include complexity factors in their strategies whereas those in developed economies focus on operational excellence and not on complexity. Therefore, at this point, businesses in developed economies may want to explore the strategies adopted by those in developing economies to accommodate diversity and the dynamic environment that require innovations.
Etodolac Containing Topical Niosomal Gel: Formulation Development and Evaluation
Directory of Open Access Journals (Sweden)
Gyati Shilakari Asthana
2016-01-01
Full Text Available The present study aimed to investigate the delivery potential of Etodolac (ETD containing topical niosomal gel. Niosomal formulations were prepared by thin film hydration method at various ratios of cholesterol and Span 60 and were evaluated with respect to particle size, shape, entrapment efficiency, and in vitro characteristics. Dicetyl phosphate (DCP was also added in the niosomal formulation. Mean particle size of niosomal formulation was found to be in the range of 2 μm to 4 μm. Niosomal formulation N2 (1 : 1 ratio of cholesterol and surfactant displayed good entrapment efficiency (96.72%. TEM analyses showed that niosomal formulation was spherical in shape. Niosomal formulation (N2 displayed high percentage of drug release after 24 h (94.91 at (1 : 1 ratio of cholesterol : surfactant. Further selected niosomal formulation was used to formulate topical gel and was characterized with respect to its various parameters such as pH, viscosity, spreadability, ex vivo study, and in vivo potential permeation. Ex vivo study showed that niosomal gel possessed better skin permeation study than the plain topical gel. Further in vivo study revealed good inhibition of inflammation in case of topical niosomal gel than plain gel and niosomal formulation. The present study suggested that topical niosomal gel formulations provide sustained and prolonged delivery of drug.
Etodolac Containing Topical Niosomal Gel: Formulation Development and Evaluation.
Shilakari Asthana, Gyati; Asthana, Abhay; Singh, Davinder; Sharma, Parveen Kumar
2016-01-01
The present study aimed to investigate the delivery potential of Etodolac (ETD) containing topical niosomal gel. Niosomal formulations were prepared by thin film hydration method at various ratios of cholesterol and Span 60 and were evaluated with respect to particle size, shape, entrapment efficiency, and in vitro characteristics. Dicetyl phosphate (DCP) was also added in the niosomal formulation. Mean particle size of niosomal formulation was found to be in the range of 2 μm to 4 μm. Niosomal formulation N2 (1 : 1) ratio of cholesterol and surfactant displayed good entrapment efficiency (96.72%). TEM analyses showed that niosomal formulation was spherical in shape. Niosomal formulation (N2) displayed high percentage of drug release after 24 h (94.91) at (1 : 1) ratio of cholesterol : surfactant. Further selected niosomal formulation was used to formulate topical gel and was characterized with respect to its various parameters such as pH, viscosity, spreadability, ex vivo study, and in vivo potential permeation. Ex vivo study showed that niosomal gel possessed better skin permeation study than the plain topical gel. Further in vivo study revealed good inhibition of inflammation in case of topical niosomal gel than plain gel and niosomal formulation. The present study suggested that topical niosomal gel formulations provide sustained and prolonged delivery of drug.
Formulation and characterization of benzoyl peroxide gellified emulsions.
Thakur, Naresh Kumar; Bharti, Pratibha; Mahant, Sheefali; Rao, Rekha
2012-01-01
The present investigation was carried out with the objective of formulating a gellified emulsion of benzoyl peroxide, an anti-acne agent. The formulations were prepared using four different vegetable oils, viz. almond oil, jojoba oil, sesame oil, and wheat germ oil, owing to their emollient properties. The idea was to overcome the skin irritation and dryness caused by benzoyl peroxide, making the formulation more tolerable. The gellified emulsions were characterized for their homogeneity, rheology, spreadability, drug content, and stability. In vitro permeation studies were performed to check the drug permeation through rat skin. The formulations were evaluated for their antimicrobial activity, as well as their acute skin irritation potential. The results were compared with those obtained for the marketed formulation. Later, the histopathological examination of the skin treated with various formulations was carried out. Formulation F3 was found to have caused a very mild dysplastic change to the epidermis. On the other hand, the marketed formulation led to the greatest dysplastic change. Hence, it was concluded that formulation F3, containing sesame oil (6%w/w), was the optimized formulation. It exhibited the maximum drug release and anti-microbial activity, in addition to the least skin irritation potential.
Colloid-Facilitated Plutonium Transport: Model Formulation and Simulations of Column Experiments
Lu, G.; Lu, G.; Wolfsberg, A.; McGraw, M.; Reimus, P.; Ware, D.
2001-12-01
Field observations indicate that plutonium, believed to be immobile due to its strong sorption to immobile media, has migrated away from the BENHAM underground nuclear test at the Nevada Test Site (NTS). The concentrations of plutonium (Pu) measured in the groundwater samples are just above the detection level and indicate that the plutonium is sorbed onto colloids, at least following sample preparation activities. In our research we have developed a model incorporating processes including sorption, speciation, interaction between Pu and colloids, Pu-colloid filtration, and colloid filtration. In natural aqueous environment, most colloids carry a negative charge, and are inclined to interact with Pu species with positive charges (dominantly PuO2+). On the other hand, Pu is apt to be sorbed onto minerals. Thus, two competitive processes between Pu colloid interactions and Pu sorption affect the Pu mobility. In our modeling effort these processes are simplified for computational efficiency. Pu speciation is represented with an equilibrium ratio between reactive and non-reactive species (e.g. PuO2(CO3)- ). Pu sorption is formulated with a lumped distribution coefficient, Kd, for PuO2+) that considers pH, oxidation potential (Eh), concentrations of relevant components, and fracture mineral compositions. Fracture minerals are quantified with active surface sites by taking into consideration the area covered by the secondary minerals, the thickness of the coating, the amount of the minerals in contact with fracture water, and their sorption site density. These processes were modeled and compared with the data from a fractured column transport experiment involving tritium, Pu, and montmorillonite colloids. One of the key findings with these models is that kinetic expressions are necessary to describe the Pu-colloid interaction and Pu-colloid filtration. This work was performed under contract with the United States Department of Energy. Los Alamos National Laboratory is
Marçais, J.; De Dreuzy, J. R.; Ginn, T. R.; Gueutin, P.; Leray, S.
2014-12-01
Transit time distributions (TTDs) play a key role in the transport processes, the interpretation of atmospheric tracer data and the predictions made on groundwater resources. However TTDs are not accessible from field measurements. Only hints on these TTDs can be obtained from anthropogenic tracer concentrations, also commonly called "groundwater ages". We evaluate the predictive capabilities of the information contained in anthropogenic tracer concentrations on groundwater renewal times through the use of Lumped Parameter Models (LPMs) instead of fully developed aquifer models. Towards this end, we develop an assessment methodology in three steps. First, a synthetic crystalline aquifer model representing the site of Plœmeur (Brittany, France) is used to give, at any point, references for observables quantities (anthropogenic tracer concentrations of CFC-11, 85Kr and SF6), for non-observables quantities (the TTDs), and for the prediction objective (groundwater renewal times). Second, several LPMs are considered with one, two or three parameters, and are parameterized by fitting the reference anthropogenic concentrations. Third, the reference renewal times obtained from the synthetic model are compared to the renewal times obtained independently from the LPMs. Statistical analyses over the aquifer show that a good fit of the anthropogenic tracer concentrations is a necessary but not sufficient condition for acceptable predictions. The use of only one anthropogenic tracer gives poor predictions differing by 7 to 12 years to the references. The use of two sufficiently different anthropogenic tracers not only reduce the errors but surprisingly yield to very accurate predictions with errors smaller than 3 years. The additional use of a third anthropogenic tracer does not improve the predictive capabilities. Careful a posteriori analyses reveal that reference TTDs have widely varying shapes from well peaked in recharge zones where flows are diverging to broadly
Marçais, J.; de Dreuzy, J.-R.; Ginn, T. R.; Rousseau-Gueutin, P.; Leray, S.
2015-06-01
While central in groundwater resources and contaminant fate, Transit Time Distributions (TTDs) are never directly accessible from field measurements but always deduced from a combination of tracer data and more or less involved models. We evaluate the predictive capabilities of approximate distributions (Lumped Parameter Models abbreviated as LPMs) instead of fully developed aquifer models. We develop a generic assessment methodology based on synthetic aquifer models to establish references for observable quantities as tracer concentrations and prediction targets as groundwater renewal times. Candidate LPMs are calibrated on the observable tracer concentrations and used to infer renewal time predictions, which are compared with the reference ones. This methodology is applied to the produced crystalline aquifer of Plœmeur (Brittany, France) where flows leak through a micaschists aquitard to reach a sloping aquifer where they radially converge to the producing well, issuing broad rather than multi-modal TTDs. One, two and three parameters LPMs were calibrated to a corresponding number of simulated reference anthropogenic tracer concentrations (CFC-11, 85Kr and SF6). Extensive statistical analysis over the aquifer shows that a good fit of the anthropogenic tracer concentrations is neither a necessary nor a sufficient condition to reach acceptable predictive capability. Prediction accuracy is however strongly conditioned by the use of a priori relevant LPMs. Only adequate LPM shapes yield unbiased estimations. In the case of Plœmeur, relevant LPMs should have two parameters to capture the mean and the standard deviation of the residence times and cover the first few decades [0; 50 years]. Inverse Gaussian and shifted exponential performed equally well for the wide variety of the reference TTDs from strongly peaked in recharge zones where flows are diverging to broadly distributed in more converging zones. When using two sufficiently different atmospheric tracers like
Wilson, C. G.; Wacha, K.; Papanicolaou, T.; Stanier, C. O.; Jamroensan, A.
2014-12-01
In this study, Net Ecosystem Exchange (NEE), and its components Gross Ecosystem Exchange (GEE) and Ecosystem Respiration (RESP), were compared from a lumped, regional model and a mechanistic, hillslope-scale model to determine if the effects of land management on the carbon cycle are captured by larger-scale biosphere models that determine CO2 sources and sinks. WRF-VPRM (Weather Research & Forecasting - Vegetation Photosynthesis & Respiration Model) is a regional-scale model that uses simulated downward shortwave radiation and surface temperatures, along with satellite-derived land cover indices and eddy flux tower-derived parameters to estimate biosphere CO2 fluxes with empirical equations. The DAYCENT biogeochemical model coupled with the Watershed Erosion Prediction Project model (WEPP), which simulates changes in soil carbon stocks due to different land management and the resulting enhanced erosion, can also quantify biosphere CO2 fluxes. Both models (i.e., WRF-VPRM and WEPP-DAYCENT) were used to quantify GEE, RESP, and NEE for the summer of 2008 in the IML-CZO Clear Creek watershed of the U.S. Midwest to examine the role of land management heterogeneity in CO2 exchanges between the biosphere and atmosphere. Comparing average daily GEE rates from WRF-VPRM (-11.0 ± 5.2 g C/m2/d) with WEPP-DAYCENT average values weighted per land use area in the watershed (-10.2 ± 1.5 g C/m2/d) showed no significant differences (t-test; p=0.08). In contrast, daily RESP values were different between the two models. Daily respiration rates were relatively constant for WRF-VPRM (6.0 ± 0.8 g C/m2/d), while WEPP-DAYCENT values for each management practice were significantly greater (7.2 ± 1.8 g C/m2/d; t-test, pmanagement and net erosion/deposition on total SOC stocks and tillage impacts on respiration by increasing decomposition from the breaking of soil aggregates and enhanced mineralization. In WRF-VPRM, respiration is calculated with a regression equation based on air
Wolff-Menzler, C; Große, C
2015-05-01
This paper surveys the effects of day-based lump-sum remuneration as defined by the PEPP system on the patients' length of stay and compares its incentives to the mechanisms of the German DRG system and the former remunera-tion system for stationary psychiatric and psychosomatic treatments. The analysis identifies the economically optimal length of stay defined as the profit maximising duration of treatment by comparing marginal revenues and marginal costs. Since it is economically optimal to extend the treatment until the marginal costs exceed the marginal revenues, psychiatric and psychosomatic facilities are incentivised to minimise the time gap between average duration of treatment as expected duration of treatment and the economically optimal length of stay. Compared to the German DRG system, which provides a strong incentive to reduce length of stay, the incentives set by the PEPP system imply either a reduction or an extension of treatment duration depending on the underlying cost function. If a degressive cost function is assumed, which is typical for treatments of psychiatric and psychosomatic illnesses, the economically optimal duration of treatment will be at the last upper boundary of the interval of the marginal revenue function in which the average marginal revenues exceed the average marginal costs. It is also feasible that it is economically optimal to treat the patient for as long as possible. The hospital is incentivised to extend or reduce the time of treatment to this point in time. Psychiatric and psychosomatic hospitals are able to increase their profits by reducing or extending time of treatment. Therefore these facilities have to justify the extent of treatment to the health insurance companies. Since the incentives of the PEPP system and the DRG system diverge, the results of research on supply induced demand in the DRG system cannot be transferred to the discussion about the effects of the introduction of the PEPP system. As long as the
A Hamiltonian Formulation On Tsunami Over Swell
TIAN, M.; Sheremet, A.; Kaihatu, J. M.
2012-12-01
Tsunami induced by earthquakes typically evolves shore-ward with a significant amplification of amplitude during the last stages of shoaling. This study focuses on tsunami evolution in shallow water under the effects of the oceanographic environment such as breaking and tsunami- swell interaction. One generally describes wave breaking directly with a discontinuity in the solution to the classical nonlinear shallow water equations (NLSW) (e.g., Stoker 1985). This wave-front steepness calculation, however, has the potential problem that for the case of the single wave defined by solitary wave, breaking occurs much closer to the wave crest so that the method is formally invalid (Madsen et. al. 2008). Li and Raichlen (2002) applied a weighted essentially non-oscillatory (WENO) shock-capturing scheme in the numerical NSWE model to capture the wave breaking process. The problem arises that a convenient hamiltonian formalism is lacking to describe wave breaking. One wants to evaluate breaking by deducing the decay of the tsunami energy in a straightforward manner. The linear effect of the tsunami background circulation on swell is well known (e.g., Madsen et. al. 2008). However, Kaihatu and El Safty(2011) hypothesized that this is only one "half" of the mutual interaction between the tsunami and the overlying swell field, which might have subtle effects on the tsunami front-face steepness and breaking process. These effects were observed in a laboratory experiments (Kaihatu and El Safty 2011). It was observed that the presence of swell affects the maximum surface amplitude of overall wave field and produces significant energy shifts to high frequencies, thus promoting tsunami breaking. The theoretical study for tsunami-swell interaction requires a phase-resolving wave-wave interaction model. In this study, we derive a Hamiltonian formulation for the tsunami-swell interaction using the quasi stream-function formulation. This formalism is better able to handle uneven
Nonequilibrium formulation of abelian gauge theories
Energy Technology Data Exchange (ETDEWEB)
Zoeller, Thorsten
2013-09-01
This work is about a formulation of abelian gauge theories out-of-equilibrium. In contrast to thermal equilibrium, systems out-of-equilibrium are not constant in time, and the interesting questions in such systems refer to time evolution problems. After a short introduction to quantum electrodynamics (QED), the two-particle irreducible (2PI) effective action is introduced as an essential technique for the study of quantum field theories out-of-equilibrium. The equations of motion (EOMs) for the propagators of the theory are then derived from it. It follows a discussion of the physical degrees of freedom (DOFs) of the theory, in particular with respect to the photons, since in covariant formulations of gauge theories unphysical DOFs are necessarily contained. After that the EOMs for the photon propagator are examined more closely. It turns out that they are structurally complicated, and a reformulation of the equations is presented which for the untruncated theory leads to an essential structural simplification of the EOMs. After providing the initial conditions which are necessary in order to solve the EOMs, the free photon EOMs are solved with the help of the reformulated equations. It turns out that the solutions diverge in time, i.e. they are secular. This is a manifestation of the fact that gauge theories contain unphysical DOFs. It is reasoned that these secularities exist only in the free case and are therefore ''artificial''. It is however emphasized that they may not be a problem in principle, but certainly are in practice, in particular for the numerical solution of the EOMs. Further, the origin of the secularities, for which there exists an illustrative explanation, is discussed in more detail. Another characteristic feature of 2PI formulations of gauge theories is the fact that quantities calculated from approximations of the 2PI effective action, which are gauge invariant in the exact theory as well as in an approximated theory at
States in the Hilbert space formulation and in the phase space formulation of quantum mechanics
International Nuclear Information System (INIS)
Tosiek, J.; Brzykcy, P.
2013-01-01
We consider the problem of testing whether a given matrix in the Hilbert space formulation of quantum mechanics or a function considered in the phase space formulation of quantum theory represents a quantum state. We propose several practical criteria for recognising states in these two versions of quantum physics. After minor modifications, they can be applied to check positivity of any operators acting in a Hilbert space or positivity of any functions from an algebra with a ∗-product of Weyl type. -- Highlights: ► Methods of testing whether a given matrix represents a quantum state. ► The Stratonovich–Weyl correspondence on an arbitrary symplectic manifold. ► Criteria for checking whether a function on a symplectic space is a Wigner function
Aggarwal, Nidhi; Goindi, Shishu; Khurana, Ranjit
2013-05-01
The main objective of the study was to develop a microemulsion (ME) formulation of griseofulvin for the treatment of dermatophytosis (Indian Patent Application 208/DEL/2009). The oil phase was selected on the basis of drug solubility whereas the surfactant and cosurfactant were screened on the basis of their oil solubilizing capacity as well as their efficiency to form ME from pseudo-ternary phase diagrams. The influence of surfactant and cosurfactant mass ratio (Smix) on the ME formation and its permeation through male Laca mice skin was studied. The optimized formulation (ME V) consisting of 0.2% (w/w) griseofulvin, 5% (w/w) oleic acid, 40% (w/w) Smix (1:1, Tween 80 and ethanol) possessed globule size of 12.21 nm, polydispersity index of 0.109 and zeta potential value of -0.139 mV. ME V exhibited 7, 5 and almost 3-fold higher drug permeation as compared to aqueous suspension, oily solution and conventional cream respectively. Besides this the formulation was also evaluated for drug content, pH, stability, dermatopharmacokinetics and antifungal activity against Microsporum canis using guinea pig model for dermatophytosis. Treatment of guinea pigs with ME V resulted in a complete clinical and mycological cure in 7 days. The formulation was observed to be non-sensitizing, histopathologically safe, and stable at 5±3°C, 25±2°C and 40±2°C for a period of six months. Copyright © 2013 Elsevier B.V. All rights reserved.
Skin moisturizing effects of panthenol-based formulations.
Camargo, Flávio B; Gaspar, Lorena R; Maia Campos, Patrícia M B G
2011-01-01
This study aims to evaluate the skin moisturizing efficacy of formulations containing different concentrations of panthenol. Formulations supplemented with or without 0.5%, 1.0%, or 5.0% panthenol were applied daily to the forearms of healthy subjects. Skin conditions in terms of moisture and transepidermal water loss (TEWL) were analyzed before and after 15- and 30-day periods of application. The formulations were also applied after skin washing with sodium laureth sulphate (SLES) to evaluate the immediate effects on TEWL and skin moisture. Panthenol-containing formulations (1.0% and 5.0%) produced significant decreases in TEWL after 30-day applications. In skin washed with SLES, significant reduction of TEWL was evident two hours after application of formulations loaded with panthenol when compared with control and vehicle. It is concluded that skin integrity is maintained by the improved protective effect of 1.0% panthenol added to the formulation.
Velocity potential formulations of highly accurate Boussinesq-type models
DEFF Research Database (Denmark)
Bingham, Harry B.; Madsen, Per A.; Fuhrman, David R.
2009-01-01
is of interest because it reduces the computational effort by approximately a factor of two and facilitates a coupling to other potential flow solvers. A new shoaling enhancement operator is introduced to derive new models (in both formulations) with a velocity profile which is always consistent...... structures. Coast. Eng. 53, 929-945) are re-derived in a more general framework which establishes the correct relationship between the model in a velocity formulation and a velocity potential formulation. Although most work with this model has used the velocity formulation, the potential formulation...... with the kinematic bottom boundary condition. The true behaviour of the velocity potential formulation with respect to linear shoaling is given for the first time, correcting errors made by Jamois et al. (Jamois, E., Fuhrman, D.R., Bingham, H.B., Molin, B., 2006. Wave-structure interactions and nonlinear wave...
Element free Galerkin formulation of composite beam with longitudinal slip
Energy Technology Data Exchange (ETDEWEB)
Ahmad, Dzulkarnain; Mokhtaram, Mokhtazul Haizad [Department of Civil Engineering, Universiti Selangor, Bestari Jaya, Selangor (Malaysia); Badli, Mohd Iqbal; Yassin, Airil Y. Mohd [Faculty of Civil Engineering, Universiti Teknologi Malaysia, Skudai, Johor (Malaysia)
2015-05-15
Behaviour between two materials in composite beam is assumed partially interact when longitudinal slip at its interfacial surfaces is considered. Commonly analysed by the mesh-based formulation, this study used meshless formulation known as Element Free Galerkin (EFG) method in the beam partial interaction analysis, numerically. As meshless formulation implies that the problem domain is discretised only by nodes, the EFG method is based on Moving Least Square (MLS) approach for shape functions formulation with its weak form is developed using variational method. The essential boundary conditions are enforced by Langrange multipliers. The proposed EFG formulation gives comparable results, after been verified by analytical solution, thus signify its application in partial interaction problems. Based on numerical test results, the Cubic Spline and Quartic Spline weight functions yield better accuracy for the EFG formulation, compares to other proposed weight functions.
Directory of Open Access Journals (Sweden)
Martina Bortignon
2011-12-01
Full Text Available In this essay, I suggest an interpretation of Lumpérica (1983 by the Chilean novelist Diamela Eltit, as an aesthetic response to the biopolitical strategies of the neoliberal regime during the Pinochet's dictatorship, as well as in more recent years. Based on the performative actions of a beggar – a figure of social marginality –, the novel enacts an ambivalence that I analyze in relation to space, language and identity, pointing out its “perverting” potentiality in relation to the social and symbolic order.
Martina Bortignon
2011-01-01
In this essay, I suggest an interpretation of Lumpérica (1983) by the Chilean novelist Diamela Eltit, as an aesthetic response to the biopolitical strategies of the neoliberal regime during the Pinochet's dictatorship, as well as in more recent years. Based on the performative actions of a beggar – a figure of social marginality –, the novel enacts an ambivalence that I analyze in relation to space, language and identity, pointing out its “perverting” potentiality in relation to the social an...
Nodally Integrated Finite Element Formulation for Mindlin-Reissner Plates
Simoes, D. A.; Jadhav, T. A.
2014-01-01
This work describes a nodally integrated finite element formulation for plates under the Mindlin-Reissner theory. The formulation makes use of the weighted residual method and nodal integration to derive the assumed strain relations. An element formulation for four-node quadrilateral elements is implemented in the nonlinear finite element solver Abaqus using the UEL user element subroutine. Numerical tests are carried out on the new element and the results are presented.
Formulation and evaluation of antipsoriatic gel using natural excipients
Raghupatruni Jhansi Laxmi; R. Karthikeyan; P. Srinivasa Babu; R.V.V. Narendra Babu
2013-01-01
Objective: To develop topical gel formulations of Psoralen using natural excipients to minimize the side effects of synthetic drugs. Methods: The Psoralen gel formulations were prepared using different natural gums and polymers. The physicochemical compatibility between Psoralen and other excipients was confirmed by using Fourier transform infrared spectroscopy. All prepared gel formulations were evaluated for drug content uniformity, viscosity, pH, and stability. The release of psoralen f...
International Nuclear Information System (INIS)
Mashhour, M.; Golkar, M.A.; Moghaddas-Tafreshi, S.M.
2011-01-01
This work presents a novel hourly-ahead profit model for an active distribution company (DISCO), a DISCO with high capacity level of connected DGs that can make selling proposals for the markets, in a pool-based system. The presented model engages DSICO in both energy producing and reserve providing activities. DISCO's earnings from reserve market include the remuneration both for real-time generation and ready-for-service capacity. To achieve the optimal decisions for an active DISCO in the energy and reserve markets, a two-stage optimization model and associated mathematical formulations have been developed. The first subproblem extracts a single operating profile (a lumped financial model) of the whole distribution system, including DGs and ILs, at the connecting point to the upstream network. The second one determines the optimal values of decision variables (power and reserve commodities) to maximize the DISCO's profit, in case such variables are accepted in the markets. In other words, it aims to optimally allocate the DISCO's generating capability for proposing into the energy and reserve markets, from the DISCO's perspective. It also proposes a profit-based network reconfiguration methodology for a multi-substation multi-feeder DISCO to increase DISCO's ability to gain more benefits from the market activities. It conducts DISCO's generating capabilities towards the proper substations to reap more probable benefits. It also introduces fast, simple, and straightforward algorithms for recognition and removal of configurations having loop and/or islanding parts in. Simulation results are given at the second part of the present work.
Controlled Release Formulations of Auxinic Herbicides
Kowalski, Witold J.; Siłowiecki, Andrzej.; Romanowska, Iwona; Glazek, Mariola; Bajor, Justyna; Cieciwa, Katarzyna; Rychter, Piotr
2013-04-01
Controlled release formulations are applied extensively for the release of active ingredients such as plant protection agents and fertilizers in response to growing concern for ecological problems associated with increased use of plant protection chemicals required for intensive agricultural practices [1]. We synthesized oligomeric mixtures of (R,S)-3-hydroxy butyric acid chemically bonded with 2,4-D, Dicamba and MCPA herbicides (HBA) respectively, and determined their molecular structure and molecular weight dispersion by the size exclusion chromatography, proton magnetic resonance spectrometry and electro-spray ionization mass spectrometry. Further we carried out bioassays of herbicidal effectiveness of the HBA herbicides vs. series of dicotyledonous weeds and crop injury tests [2, 3, 4]. Field bioassays were accomplished according to the EPPO standards [5]. Groups of representative weeds (the development stages in the BCCH scale: 10 - 30) were selected as targets. Statistical variabilities were assessed by the Fisher LSD test for plants treated with the studied herbicides in form of HBA oligomers, the reference herbicides in form of dimethyl ammonium salts (DMA), and untreated plants. No statistically significant differences in the crop injuries caused by the HBA vs. the DMA reference formulation were observed. The effectiveness of the HBA herbicides was lower through the initial period (ca. 2 weeks) relative to the DMA salts, but a significant increase in the effectiveness of the HBA systems followed during the remaining fraction of each assay. After 6 weeks all observed efficiencies approached 100%. The death of weeds treated with the HBA herbicides was delayed when compared with the DMA reference herbicides. The delayed uptake observed for the HBA oligomers relative to the DMA salts was due to controlled release phenomena. In case of the DMA salts the total amount of active ingredients was available at the target site. By contrast, the amount of an active
Formulating liquid hydrocarbon fuels for SOFCs
Saunders, G. J.; Preece, J.; Kendall, K.
The injection of liquid hydrocarbons directly into an SOFC system is considered for application to hybrid vehicles. The main problem is carbon deposition on the nickel anode when molecules such as ethanol or iso-octane are injected directly. Such carbon deposition has been studied using a microtubular SOFC with a mass spectrometer analysing the product gases to investigate the reaction sequence and also to investigate the deposited carbon by temperature programmed oxidation (TPO). The results show that only two liquids could be injected directly onto nickel cermet anodes without serious carbon blockage, methanol and methanoic acid. Even then, TPO experiments revealed deposition of small amounts of carbon which could be prevented by small additions of air or water to the fuel. Gasoline type molecules like iso-octane killed the SOFC in about 30 min operation, with about 90% of the molecular carbon being deposited on the nickel cermet anode. However, certain mixtures of iso-octane, water, alcohol and surfactant were found to produce beneficial results with remarkably low carbon deposition, less than 1% of the molecular carbon appearing on the anode. Such formulations had octane numbers appropriate to internal combustion engine operation.
Biosurfactants in cosmetic formulations: trends and challenges.
Vecino, X; Cruz, J M; Moldes, A B; Rodrigues, L R
2017-11-01
Cosmetic products play an essential role in everyone's life. People everyday use a large variety of cosmetic products such as soap, shampoo, toothpaste, deodorant, skin care, perfume, make-up, among others. The cosmetic industry encompasses several environmental, social and economic impacts that are being addressed through the search for more efficient manufacturing techniques, the reduction of waste and emissions and the promotion of personal hygiene, contributing to an improvement of public health and at the same time providing employment opportunities. The current trend among consumers is the pursuit for natural ingredients in cosmetic products, as many of these products exhibit equal, better or additional benefits in comparison with the chemical-based products. In this sense, biosurfactants are natural compounds with great potential in the formulation of cosmetic products given by their biodegradability and impact in health. Indeed, many of these biosurfactants could exhibit a "prebiotic" character. This review covers the current state-of-the-art of biosurfactant research for cosmetic purposes and further discusses the future challenges for cosmetic applications.
Extended release formulations for local anaesthetic agents.
Weiniger, C F; Golovanevski, L; Domb, A J; Ickowicz, D
2012-08-01
Systemic toxicity through overdose of local anaesthetic agents is a real concern. By encapsulating local anaesthetics in biodegradable carriers to produce a system for prolonged release, their duration of action can be extended. This encapsulation should also improve the safety profile of the local anaesthetic as it is released at a slower rate. Work with naturally occurring local anaestheticss has also shown promise in the area of reducing systemic and neurotoxicity. Extended duration local anaesthetic formulations in current development or clinical use include liposomes, hydrophobic based polymer particles such as Poly(lactic-co-glycolic acid) microspheres, pasty injectable and solid polymers like Poly(sebacic-co-ricinoleic acid) P(SA:RA) and their combination with synthetic and natural local anaesthetic. Their duration of action, rationale and limitations are reviewed. Direct comparison of the different agents is limited by their chemical properties, the drug doses encapsulated and the details of in vivo models described. Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.
New formulations for tsunami runup estimation
Kanoglu, U.; Aydin, B.; Ceylan, N.
2017-12-01
We evaluate shoreline motion and maximum runup in two folds: One, we use linear shallow water-wave equations over a sloping beach and solve as initial-boundary value problem similar to the nonlinear solution of Aydın and Kanoglu (2017, Pure Appl. Geophys., https://doi.org/10.1007/s00024-017-1508-z). Methodology we present here is simple; it involves eigenfunction expansion and, hence, avoids integral transform techniques. We then use several different types of initial wave profiles with and without initial velocity, estimate shoreline properties and confirm classical runup invariance between linear and nonlinear theories. Two, we use the nonlinear shallow water-wave solution of Kanoglu (2004, J. Fluid Mech. 513, 363-372) to estimate maximum runup. Kanoglu (2004) presented a simple integral solution for the nonlinear shallow water-wave equations using the classical Carrier and Greenspan transformation, and further extended shoreline position and velocity to a simpler integral formulation. In addition, Tinti and Tonini (2005, J. Fluid Mech. 535, 33-64) defined initial condition in a very convenient form for near-shore events. We use Tinti and Tonini (2005) type initial condition in Kanoglu's (2004) shoreline integral solution, which leads further simplified estimates for shoreline position and velocity, i.e. algebraic relation. We then use this algebraic runup estimate to investigate effect of earthquake source parameters on maximum runup and present results similar to Sepulveda and Liu (2016, Coast. Eng. 112, 57-68).
Considering the cultural context in psychopathology formulations
Directory of Open Access Journals (Sweden)
Junaid Hassim
2013-03-01
Full Text Available Background. Mental health research appears to be continually transforming. Recent literature reflects a greater appreciation for the ways in which pathoplastic features of culture modulate emotional regulation. This article introduces those aspects of the literature which explore the (reconsideration of culture as a dynamic and essential construct in the clinical formulation of psychopathology. Objectives. The study aims to review literature that focuses on the dynamic influence of culture in psychopathology. Furthermore, the researchers aim to present a view on the ways in which culture appeared to shape the topography of psychopathology nosology. Method. A literature review of 31 sources. Results. The review indicated that 29 literature sources were conceptual in design, suggesting a great need for more empirical research. This section also explored themes identified during the literature review. The literature was tabulated according to features and emerging themes. Three major themes were identified and included: the cultural context; the evolving definitions of culture; and culture and psychopathology. Conclusion/discussion. An analysis of the themes was offered. The authors concluded by highlighting the significance of the literature at present. Areas of particular interest suggested that health and behaviour are dependent, at least in part, on culture; psychopathology may also be appreciated as a social construct; culture influences psychopathology regardless of the aetiology; diagnostic classes do not adequately consider operational definitions; and a greater focus on hermeneutic perceptivity in appreciating cultural dynamics in psychopathology will benefit clinical assessment.
Accelerating Vaccine Formulation Development Using Design of Experiment Stability Studies.
Ahl, Patrick L; Mensch, Christopher; Hu, Binghua; Pixley, Heidi; Zhang, Lan; Dieter, Lance; Russell, Ryann; Smith, William J; Przysiecki, Craig; Kosinski, Mike; Blue, Jeffrey T
2016-10-01
Vaccine drug product thermal stability often depends on formulation input factors and how they interact. Scientific understanding and professional experience typically allows vaccine formulators to accurately predict the thermal stability output based on formulation input factors such as pH, ionic strength, and excipients. Thermal stability predictions, however, are not enough for regulators. Stability claims must be supported by experimental data. The Quality by Design approach of Design of Experiment (DoE) is well suited to describe formulation outputs such as thermal stability in terms of formulation input factors. A DoE approach particularly at elevated temperatures that induce accelerated degradation can provide empirical understanding of how vaccine formulation input factors and interactions affect vaccine stability output performance. This is possible even when clear scientific understanding of particular formulation stability mechanisms are lacking. A DoE approach was used in an accelerated 37(°)C stability study of an aluminum adjuvant Neisseria meningitidis serogroup B vaccine. Formulation stability differences were identified after only 15 days into the study. We believe this study demonstrates the power of combining DoE methodology with accelerated stress stability studies to accelerate and improve vaccine formulation development programs particularly during the preformulation stage. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.
Summary of Remediated Nitrate Salt Surrogate Formulation and Testing
Energy Technology Data Exchange (ETDEWEB)
Brown, Geoffrey Wayne [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Leonard, Philip [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hartline, Ernest Leon [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Tian, Hongzhao [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
2016-05-05
High Explosives Science and Technology (M-7) completed all required formulation and testing of Remediated Nitrate Salt (RNS) surrogates on April 27, 2016 as specified in PLAN-TA9-2443 Rev B, "Remediated Nitrate Salt (RNS) Surrogate Formulation and Testing Standard Procedure", released February 16, 2016. This report summarizes the results of the work and also includes additional documentation required in that test plan. All formulation and testing was carried out according to PLAN-TA9-2443 Rev B. The work was carried out in three rounds, with the full matrix of samples formulated and tested in each round. Results from the first round of formulation and testing were documented in memorandum M7-J6-6042, " Results from First Round of Remediated Nitrate Salt Surrogate Formulation and Testing." Results from the second round of formulation and testing were documented in M7-16-6053 , "Results from the Second Round of Remediated Nitrate Salt Surrogate Formulation and Testing." Initial results from the third round were documented in M7-16-6057, "Initial Results from the Third Round of Remediated Nitrate Salt Formulation and Testing."
High-Order Entropy Stable Formulations for Computational Fluid Dynamics
Carpenter, Mark H.; Fisher, Travis C.
2013-01-01
A systematic approach is presented for developing entropy stable (SS) formulations of any order for the Navier-Stokes equations. These SS formulations discretely conserve mass, momentum, energy and satisfy a mathematical entropy inequality. They are valid for smooth as well as discontinuous flows provided sufficient dissipation is added at shocks and discontinuities. Entropy stable formulations exist for all diagonal norm, summation-by-parts (SBP) operators, including all centered finite-difference operators, Legendre collocation finite-element operators, and certain finite-volume operators. Examples are presented using various entropy stable formulations that demonstrate the current state-of-the-art of these schemes.
A new floating frame of reference formulation for flexible multibody dynamics
Schilder, Jurnan Paul
2017-01-01
For the dynamic analysis of flexible multibody systems, three conceptually different descriptions are available and commonly used: the inertial frame formulations, the corotational formulations and the floating frame formulations. The differences between these formulations are mainly in the way they
Formulating liquid ethers for microtubular SOFCs
Kendall, Kevin; Slinn, Matthew; Preece, John
One of the key problems of applying solid oxide fuel cells (SOFCs) in transportation is that conventional fuels like kerosene and diesel do not operate directly in SOFCs without prereforming to hydrogen and carbon monoxide which can be handled by the nickel cermet anode. SOFCs can internally reform certain hydrocarbon molecules such as methanol and methane. However, other liquid fuels usable in petrol or diesel internal combustion engines (ICEs) have not easily been reformable directly on the anode. This paper describes a search for liquid fuels which can be mixed with petrol or diesel and also injected directly into an SOFC without destroying the nickel anode. When fuel molecules such as octane are injected onto the conventional nickel/yttria stabilised zirconia (Ni/YSZ) SOFC fuel electrode, the anode rapidly becomes blocked by carbon deposition and the cell power drops to near zero in minutes. This degeneration of the anode can be inhibited by injection of air or water into the anode or by some upstream reforming just before entry to the SOFC. Some smaller molecules such as methane, methanol and methanoic acid produce a slight tendency to carbon deposition but not sufficient to prevent long term operation. In this project we have investigated a large number of molecules and now found that some liquid ethers do not significantly damage the anode when directly injected. These molecules and formulations with other components have been evaluated in this study. The theory put forward in this paper is that carbon-carbon bonds in the fuel are the main reason for anode damage. By testing a number of fuels without such bonds, particularly liquid ethers such as methyl formate and dimethoxy methane, it has been shown that SOFCs can run without substantial carbon formation. The proposal is that conventional fuels can be doped with these molecules to allow hybrid operation of an ICE/SOFC device.
Operator formulation of the droplet model
International Nuclear Information System (INIS)
Lee, B.W.
1987-01-01
We study in detail the implications of the operator formulation of the droplet model. The picture of high-energy scattering that emerges from this model attributed the interaction between two colliding particles at high energies to an instantaneous, multiple exchange between two extended charge distributions. Thus the study of charge correlation functions becomes the most important problem in the droplet model. We find that in order for the elastic cross section to have a finite limit at infinite energy, the charge must be a conserved one. In quantum electrodynamics the charge in question is the electric charge. In hadronic physics, we conjecture, it is the baryonic charge. Various arguments for and implications of this hypothesis are presented. We study formal properties of the charge correlation functions that follow from microcausality, T, C, P invariances, and charge conservation. Perturbation expansion of the correlation functions is studied, and their cluster properties are deduced. A cluster expansion of the high-energy T matrix is developed, and the exponentiation of the interaction potential in this scheme is noted. The operator droplet model is put to the test of reproducing the high-energy limit of elastic scattering quantum electrodynamics found by Cheng and Wu in perturbation theory. We find that the droplet model reproduces exactly the results of Cheng and Wu as to the impact factor. In fact, the ''impact picture'' of Cheng and Wu is completely equivalent to the droplet model in the operator version. An appraisal is made of the possible limitation of the model. (author). 13 refs
Bioavailability of magnesium from different pharmaceutical formulations.
Siener, Roswitha; Jahnen, Andrea; Hesse, Albrecht
2011-04-01
Magnesium is suggested to reduce intestinal oxalate absorption and to act as an inhibitor of calcium oxalate crystallization in the urine. However, previous studies have shown only minimal increase in urinary magnesium excretion following oral magnesium supplementation, possibly due to its low bioavailability. This study was performed to examine the bioavailability of magnesium from two different pharmaceutical formulations of magnesium oxide (MgO). Thirteen healthy male volunteers (22-31 years) were recruited from university students and staff, and all completed the study. During the baseline phase, subjects collected two 24-h urines while on their usual diet. Throughout the control and test phases, the subjects consumed a standardized diet calculated according to the recommendations. During the test phases, subjects received two magnesium preparations in a cross-over procedure. With each preparation, MgO-capsules and MgO-effervescent tablets, 450 mg magnesium was supplemented. On the control day and the two test days, fractional urine collection was performed and six corresponding blood samples were taken. In the follow-up phase, subjects continued to take the respective preparation while on their usual diet and collected 24-h urines weekly. With standardized conditions, urinary magnesium excretion increased by 40% after ingestion of the effervescent tablets, and by only 20% after intake of the capsules. The results indicate better bioavailability of magnesium from the effervescent tablets than from the capsules. This may be attributed to the fact that the tablets have to be dissolved in water before ingestion so that magnesium becomes ionized, which is an important precondition for absorption.
Cast Stone Formulation At Higher Sodium Concentrations
International Nuclear Information System (INIS)
Fox, K. M.; Edwards, T. A.; Roberts, K. B.
2013-01-01
A low temperature waste form known as Cast Stone is being considered to provide supplemental Low Activity Waste (LAW) immobilization capacity for the Hanford site. Formulation of Cast Stone at high sodium concentrations is of interest since a significant reduction in the necessary volume of Cast Stone and subsequent disposal costs could be achieved if an acceptable waste form can be produced with a high sodium molarity salt solution combined with a high water to premix (or dry blend) ratio. The objectives of this study were to evaluate the factors involved with increasing the sodium concentration in Cast Stone, including production and performance properties and the retention and release of specific components of interest. Three factors were identified for the experimental matrix: the concentration of sodium in the simulated salt solution, the water to premix ratio, and the blast furnace slag portion of the premix. The salt solution simulants used in this study were formulated to represent the overall average waste composition. The cement, blast furnace slag, and fly ash were sourced from a supplier in the Hanford area in order to be representative. The test mixes were prepared in the laboratory and fresh properties were measured. Fresh density increased with increasing sodium molarity and with decreasing water to premix ratio, as expected given the individual densities of these components. Rheology measurements showed that all of the test mixes produced very fluid slurries. The fresh density and rheology data are of potential value in designing a future Cast Stone production facility. Standing water and density gradient testing showed that settling is not of particular concern for the high sodium compositions studied. Heat of hydration measurements may provide some insight into the reactions that occur within the test mixes, which may in turn be related to the properties and performance of the waste form. These measurements showed that increased sodium
Cast Stone Formulation At Higher Sodium Concentrations
Energy Technology Data Exchange (ETDEWEB)
Fox, K. M. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Roberts, K. A. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Edwards, T. B. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)
2014-02-28
A low temperature waste form known as Cast Stone is being considered to provide supplemental Low Activity Waste (LAW) immobilization capacity for the Hanford site. Formulation of Cast Stone at high sodium concentrations is of interest since a significant reduction in the necessary volume of Cast Stone and subsequent disposal costs could be achieved if an acceptable waste form can be produced with a high sodium molarity salt solution combined with a high water to premix (or dry blend) ratio. The objectives of this study were to evaluate the factors involved with increasing the sodium concentration in Cast Stone, including production and performance properties and the retention and release of specific components of interest. Three factors were identified for the experimental matrix: the concentration of sodium in the simulated salt solution, the water to premix ratio, and the blast furnace slag portion of the premix. The salt solution simulants used in this study were formulated to represent the overall average waste composition. The cement, blast furnace slag, and fly ash were sourced from a supplier in the Hanford area in order to be representative. The test mixes were prepared in the laboratory and fresh properties were measured. Fresh density increased with increasing sodium molarity and with decreasing water to premix ratio, as expected given the individual densities of these components. Rheology measurements showed that all of the test mixes produced very fluid slurries. The fresh density and rheology data are of potential value in designing a future Cast Stone production facility. Standing water and density gradient testing showed that settling is not of particular concern for the high sodium compositions studied. Heat of hydration measurements may provide some insight into the reactions that occur within the test mixes, which may in turn be related to the properties and performance of the waste form. These measurements showed that increased sodium
Cast Stone Formulation At Higher Sodium Concentrations
Energy Technology Data Exchange (ETDEWEB)
Fox, K. M.; Edwards, T. A.; Roberts, K. B.
2013-10-02
A low temperature waste form known as Cast Stone is being considered to provide supplemental Low Activity Waste (LAW) immobilization capacity for the Hanford site. Formulation of Cast Stone at high sodium concentrations is of interest since a significant reduction in the necessary volume of Cast Stone and subsequent disposal costs could be achieved if an acceptable waste form can be produced with a high sodium molarity salt solution combined with a high water to premix (or dry blend) ratio. The objectives of this study were to evaluate the factors involved with increasing the sodium concentration in Cast Stone, including production and performance properties and the retention and release of specific components of interest. Three factors were identified for the experimental matrix: the concentration of sodium in the simulated salt solution, the water to premix ratio, and the blast furnace slag portion of the premix. The salt solution simulants used in this study were formulated to represent the overall average waste composition. The cement, blast furnace slag, and fly ash were sourced from a supplier in the Hanford area in order to be representative. The test mixes were prepared in the laboratory and fresh properties were measured. Fresh density increased with increasing sodium molarity and with decreasing water to premix ratio, as expected given the individual densities of these components. Rheology measurements showed that all of the test mixes produced very fluid slurries. The fresh density and rheology data are of potential value in designing a future Cast Stone production facility. Standing water and density gradient testing showed that settling is not of particular concern for the high sodium compositions studied. Heat of hydration measurements may provide some insight into the reactions that occur within the test mixes, which may in turn be related to the properties and performance of the waste form. These measurements showed that increased sodium