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Sample records for dimensionless lumped formulation

  1. Optimal Component Lumping: problem formulation and solution techniques

    DEFF Research Database (Denmark)

    Lin, Bao; Leibovici, Claude F.; Jørgensen, Sten Bay

    2008-01-01

    This paper presents a systematic method for optimal lumping of a large number of components in order to minimize the loss of information. In principle, a rigorous composition-based model is preferable to describe a system accurately. However, computational intensity and numerical issues restrict ...

  2. Simulation of nonlinear dynamics of a PWR core by an improved lumped formulation for fuel heat transfer

    International Nuclear Information System (INIS)

    Su, Jian; Cotta, Renato M.

    2000-01-01

    In this work, thermohydraulic behaviour of PWR, during reactivity insertion and partial loss-of-flow, is simulated by using a simplified mathematical model of reactor core and primary coolant. An improved lumped parameter formulation for transient heat conduction in fuel rod is used for core heat transfer modelling. Transient temperature response of fuel, cladding and coolant is analysed. (author)

  3. Energy-state formulation of lumped volume dynamic equations with application to a simplified free piston Stirling engine

    Science.gov (United States)

    Daniele, C. J.; Lorenzo, C. F.

    1979-01-01

    Lumped volume dynamic equations are derived using an energy-state formulation. This technique requires that kinetic and potential energy state functions be written for the physical system being investigated. To account for losses in the system, a Rayleigh dissipation function is also formed. Using these functions, a Lagrangian is formed and using Lagrange's equation, the equations of motion for the system are derived. The results of the application of this technique to a lumped volume are used to derive a model for the free-piston Stirling engine. The model was simplified and programmed on an analog computer. Results are given comparing the model response with experimental data.

  4. Lumped-parameter models

    Energy Technology Data Exchange (ETDEWEB)

    Ibsen, Lars Bo; Liingaard, M.

    2006-12-15

    A lumped-parameter model represents the frequency dependent soil-structure interaction of a massless foundation placed on or embedded into an unbounded soil domain. In this technical report the steps of establishing a lumped-parameter model are presented. Following sections are included in this report: Static and dynamic formulation, Simple lumped-parameter models and Advanced lumped-parameter models. (au)

  5. Dimensionless numbers in additive manufacturing

    Science.gov (United States)

    Mukherjee, T.; Manvatkar, V.; De, A.; DebRoy, T.

    2017-02-01

    The effects of many process variables and alloy properties on the structure and properties of additively manufactured parts are examined using four dimensionless numbers. The structure and properties of components made from 316 Stainless steel, Ti-6Al-4V, and Inconel 718 powders for various dimensionless heat inputs, Peclet numbers, Marangoni numbers, and Fourier numbers are studied. Temperature fields, cooling rates, solidification parameters, lack of fusion defects, and thermal strains are examined using a well-tested three-dimensional transient heat transfer and fluid flow model. The results show that lack of fusion defects in the fabricated parts can be minimized by strengthening interlayer bonding using high values of dimensionless heat input. The formation of harmful intermetallics such as laves phases in Inconel 718 can be suppressed using low heat input that results in a small molten pool, a steep temperature gradient, and a fast cooling rate. Improved interlayer bonding can be achieved at high Marangoni numbers, which results in vigorous circulation of liquid metal, larger pool dimensions, and greater depth of penetration. A high Fourier number ensures rapid cooling, low thermal distortion, and a high ratio of temperature gradient to the solidification growth rate with a greater tendency of plane front solidification.

  6. Revisiting Appendicular Lump

    Directory of Open Access Journals (Sweden)

    R S Bhandari

    2010-06-01

    Full Text Available INTRODUCTION: Appendicular lump is a well known sequalae of acute appendicitis encountered in 2-6% of patients. Successful management of appendicular lump is controversial with different approaches. As many controversies are arising regarding management of appendicular lump. The aim of this study was to find out the outcome and evaluate possible need of changing our management strategy of appendicular lump. METHODS: A retrospective analysis of the patients managed with appendicular lump were done. All the patients admitted with diagnosis of appendicular lump and managed between, over two and half years, were included in the study. All age groups and both sex were included. Any patients whose diagnosis was changed after initial diagnosis of appendicular lump were excluded from the study. RESULTS: Total 75 patients had appendicular lump suggesting 10% incidence. Age varied between 11-83 years with nearly equal incidence in both sexes. Majority had onset of symptoms between 2 to 14 days with an average of 4 days. Average stay was 3 to 4 days. During study period, 12 (16% came with recurrence and 13 (17% cases came for elective appendectomy. CONCLUSIONS: Based on our finding, it is not sufficient to change our classical management strategy of appendicular lump and suggests a need for long term prospective study in this very common clinical condition. KEYWORDS: appendicular lump, conservative management.

  7. Revisiting appendicular lump.

    Science.gov (United States)

    Bhandari, R S; Thakur, D K; Lakhey, P J; Singh, K P

    2010-01-01

    Appendicular lump is a well known sequalae of acute appendicitis encountered in 2-6% of patients. Successful management of appendicular lump is controversial with different approaches. As many controversies are arising regarding management of appendicular lump. The aim of this study was to find out the outcome and evaluate possible need of changing our management strategy of appendicular lump. A retrospective analysis of the patients managed with appendicular lump were done. All the patients admitted with diagnosis of appendicular lump and managed between, over two and half years, were included in the study. All age groups and both sex were included. Any patients whose diagnosis was changed after initial diagnosis of appendicular lump were excluded from the study. Total 75 patients had appendicular lump suggesting 10% incidence. Age varied between 11-83 years with nearly equal incidence in both sexes. Majority had onset of symptoms between 2 to 14 days with an average of 4 days. Average stay was 3 to 4 days. During study period, 12 (16%) came with recurrence and 13 (17%) cases came for elective appendectomy. Based on our finding, it is not sufficient to change our classical management strategy of appendicular lump and suggests a need for long term prospective study in this very common clinical condition.

  8. Comments on lump solutions in SFT

    International Nuclear Information System (INIS)

    Bonora, Loriano; Tolla, Driba D.

    2016-01-01

    We analyze a recently proposed scheme to construct analytic lump solutions in open SFT. We argue that in order for the scheme to be operative and to guarantee background independence it must be implemented in the same 2D conformal field theory in which SFT is formulated. We outline and discuss two different possible approaches. Next we reconsider an older proposal for analytic lump solutions and implement a few improvements. In the course of the analysis we formulate a distinction between regular and singular gauge transformations and advocate the necessity of defining a topology in the space of string fields. (orig.)

  9. Comments on lump solutions in SFT

    Energy Technology Data Exchange (ETDEWEB)

    Bonora, Loriano; Tolla, Driba D. [International School for Advanced Studies (SISSA), Trieste (Italy); INFN, Sezione di Trieste, Trieste (Italy)

    2016-04-15

    We analyze a recently proposed scheme to construct analytic lump solutions in open SFT. We argue that in order for the scheme to be operative and to guarantee background independence it must be implemented in the same 2D conformal field theory in which SFT is formulated. We outline and discuss two different possible approaches. Next we reconsider an older proposal for analytic lump solutions and implement a few improvements. In the course of the analysis we formulate a distinction between regular and singular gauge transformations and advocate the necessity of defining a topology in the space of string fields. (orig.)

  10. Causes of breast lumps (image)

    Science.gov (United States)

    ... breast lumps are benign (non-cancerous), as in fibroadenoma, a condition that mostly affects women under age ... with the menstrual cycle, whereas a lump from fibroadenoma does not. While most breast lumps are benign, ...

  11. Improved lumped models for transient combined convective and radiative cooling of multi-layer composite slabs

    International Nuclear Information System (INIS)

    An Chen; Su Jian

    2011-01-01

    Improved lumped parameter models were developed for the transient heat conduction in multi-layer composite slabs subjected to combined convective and radiative cooling. The improved lumped models were obtained through two-point Hermite approximations for integrals. Transient combined convective and radiative cooling of three-layer composite slabs was analyzed to illustrate the applicability of the proposed lumped models, with respect to different values of the Biot numbers, the radiation-conduction parameter, the dimensionless thermal contact resistances, the dimensionless thickness, and the dimensionless thermal conductivity. It was shown by comparison with numerical solution of the original distributed parameter model that the higher order lumped model (H 1,1 /H 0,0 approximation) yielded significant improvement of average temperature prediction over the classical lumped model. In addition, the higher order (H 1,1 /H 0,0 ) model was applied to analyze the transient heat conduction problem of steel-concrete-steel sandwich plates. - Highlights: → Improved lumped models for convective-radiative cooling of multi-layer slabs were developed. → Two-point Hermite approximations for integrals were employed. → Significant improvement over classical lumped model was achieved. → The model can be applied to high Biot number and high radiation-conduction parameter. → Transient heat conduction in steel-concrete-steel sandwich pipes was analyzed as an example.

  12. Lump wood combustion process

    Science.gov (United States)

    Kubesa, Petr; Horák, Jiří; Branc, Michal; Krpec, Kamil; Hopan, František; Koloničný, Jan; Ochodek, Tadeáš; Drastichová, Vendula; Martiník, Lubomír; Malcho, Milan

    2014-08-01

    The article deals with the combustion process for lump wood in low-power fireplaces (units to dozens of kW). Such a combustion process is cyclical in its nature, and what combustion facility users are most interested in is the frequency, at which fuel needs to be stoked to the fireplace. The paper defines the basic terms such as burnout curve and burning rate curve, which are closely related to the stocking frequency. The fuel burning rate is directly dependent on the immediate thermal power of the fireplace. This is also related to the temperature achieved in the fireplace, magnitude of flue gas losses and the ability to generate conditions favouring the full burnout of the fuel's combustible component, which, at once ensures the minimum production of combustible pollutants. Another part of the paper describes experiments conducted in traditional fireplaces with a grate, at which well-dried lump wood was combusted.

  13. A noteworthy dimensionless constant in gravitation theory

    International Nuclear Information System (INIS)

    Fayos, F.; Lobo, J.A.; Llanta, E.

    1986-01-01

    A simple problem of gravitation is studied classically and in the Schwarzchild framework. A relationship is found between the parameters that define the trajectories of two particles (the first in radial motion and the second in a circular orbit) which are initially together and meet again after one revolution of particle 2. Dimensional analysis is the clue to explain the appearance of a dimensionless constant in the Newtonian case. (author)

  14. Dimensionless groups for multidimensional heat and mass transfer in adsorbed natural gas storage

    Energy Technology Data Exchange (ETDEWEB)

    Sphaier, L.A. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Programa de Pos-Graduacao em Engenharia Mecanica. Lab. de Mecanica Teorica e Aplicada], E-mail: lasphaier@mec.uff.br

    2010-07-01

    This paper provides a new methodology for analyzing heat and mass transfer in gas storage via adsorption. The foundation behind the proposed methodology comprises a set of physically meaningful dimensionless groups. A discussion regarding the development of such groups is herein presented, providing a fully normalized multidimensional formulation for describing the transport mechanisms involved in adsorbed gas storage. After such presentation, data from previous literature studies associated with the problem of adsorbed natural gas storage are employed for determining realistic values for the developed parameters. Then, a one-dimensional test-case problem is selected for illustrating the application of the dimensionless formulation for simulating the operation of adsorbed gas reservoirs. The test problem is focused on analyzing an adsorbed gas discharge operation. This problem is numerically solved, and the solution is verified against previously published literature data. The presented results demonstrate how a higher heat of sorption values lead to reduced discharge capacities. (author)

  15. Lumped-Parameter Models for Windturbine Footings on Layered Ground

    DEFF Research Database (Denmark)

    Andersen, Lars

    The design of modern wind turbines is typically based on lifetime analyses using aeroelastic codes. In this regard, the impedance of the foundations must be described accurately without increasing the overall size of the computationalmodel significantly. This may be obtained by the fitting...... of a lumped-parameter model to the results of a rigorous model or experimental results. In this paper, guidelines are given for the formulation of such lumped-parameter models and examples are given in which the models are utilised for the analysis of a wind turbine supported by a surface footing on a layered...

  16. Determination of Dimensionless Attenuation Coefficient in Shaped Resonators

    Science.gov (United States)

    Daniels, C.; Steinetz, B.; Finkbeiner, J.; Raman, G.; Li, X.

    2003-01-01

    The value of dimensionless attenuation coefficient is an important factor when numerically predicting high-amplitude acoustic waves in shaped resonators. Both the magnitude of the pressure waveform and the quality factor rely heavily on this dimensionless parameter. Previous authors have stated the values used, but have not completely explained their methods. This work fully describes the methodology used to determine this important parameter. Over a range of frequencies encompassing the fundamental resonance, the pressure waves were experimentally measured at each end of the shaped resonators. At the corresponding dimensionless acceleration, the numerical code modeled the acoustic waveforms generated in the resonator using various dimensionless attenuation coefficients. The dimensionless attenuation coefficient that most closely matched the pressure amplitudes and quality factors of the experimental and numerical results was determined to be the value to be used in subsequent studies.

  17. Effects of soil-structure in high-rise buildings by means of dimensionless analysis and a simplified model

    NARCIS (Netherlands)

    Gómez, S.S.; Pruiksma, J.

    2017-01-01

    In this paper simplified expressions for assessing fundamental frequency and modal damping of high-rise buildings taking into account the soil-structure interaction (SSI) are proposed. To this end, several steps have been followed. First, a 3DoF model is formulated making use of dimensionless

  18. Lumped transmission line avalanche pulser

    Science.gov (United States)

    Booth, Rex

    1995-01-01

    A lumped linear avalanche transistor pulse generator utilizes stacked transistors in parallel within a stage and couples a plurality of said stages, in series with increasing zener diode limited voltages per stage and decreasing balanced capacitance load per stage to yield a high voltage, high and constant current, very short pulse.

  19. Dimensionless study on dynamics of pressure controlled mechanical ventilation system

    International Nuclear Information System (INIS)

    Shi, Yan; Niu, Jinglong; Cai, Maolin; Xu, Weiqing

    2015-01-01

    Dynamics of mechanical ventilation system can be referred in pulmonary diagnostics and treatments. In this paper, to conveniently grasp the essential characteristics of mechanical ventilation system, a dimensionless model of mechanical ventilation system is presented. For the validation of the mathematical model, a prototype mechanical ventilation system of a lung simulator is proposed. Through the simulation and experimental studies on the dimensionless dynamics of the mechanical ventilation system, firstly, the mathematical model is proved to be authentic and reliable. Secondly, the dimensionless dynamics of the mechanical ventilation system are obtained. Last, the influences of key parameters on the dimensionless dynamics of the mechanical ventilation system are illustrated. The study provides a novel method to study the dynamic of mechanical ventilation system, which can be referred in the respiratory diagnostics and treatment.

  20. Dimensionless study on dynamics of pressure controlled mechanical ventilation system

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Yan; Niu, Jinglong; Cai, Maolin; Xu, Weiqing [Beihang University, Beijing (Korea, Republic of)

    2015-02-15

    Dynamics of mechanical ventilation system can be referred in pulmonary diagnostics and treatments. In this paper, to conveniently grasp the essential characteristics of mechanical ventilation system, a dimensionless model of mechanical ventilation system is presented. For the validation of the mathematical model, a prototype mechanical ventilation system of a lung simulator is proposed. Through the simulation and experimental studies on the dimensionless dynamics of the mechanical ventilation system, firstly, the mathematical model is proved to be authentic and reliable. Secondly, the dimensionless dynamics of the mechanical ventilation system are obtained. Last, the influences of key parameters on the dimensionless dynamics of the mechanical ventilation system are illustrated. The study provides a novel method to study the dynamic of mechanical ventilation system, which can be referred in the respiratory diagnostics and treatment.

  1. Lumped Mass Modeling for Local-Mode-Suppressed Element Connectivity

    DEFF Research Database (Denmark)

    Joung, Young Soo; Yoon, Gil Ho; Kim, Yoon Young

    2005-01-01

    connectivity parameterization (ECP) is employed. On the way to the ultimate crashworthy structure optimization, we are now developing a local mode-free topology optimization formulation that can be implemented in the ECP method. In fact, the local mode-freeing strategy developed here can be also used directly...... experiencing large structural changes, appears to be still poor. In ECP, the nodes of the domain-discretizing elements are connected by zero-length one-dimensional elastic links having varying stiffness. For computational efficiency, every elastic link is now assumed to have two lumped masses at its ends....... Choosing appropriate penalization functions for lumped mass and link stiffness is important for local mode-free results. However, unless the objective and constraint functions are carefully selected, it is difficult to obtain clear black-and-white results. It is shown that the present formulation is also...

  2. Classification of whole wheat flour using a dimensionless number.

    Science.gov (United States)

    Sehn, Georgia Ane Raquel; Steel, Caroline Joy

    2017-11-01

    The rheological standards currently used for classifying refined wheat flour for technological quality of bread are also used for whole wheat flours. The aim of this study was to evaluate the rheological and technological behavior of different whole wheat flours, as well as pre-mixes of refined wheat flour with different replacement levels of wheat bran, to develop a dimensionless number that assigns a numerical scale using results of rheological parameters to solve this problem. Through farinograph and extensograph results, most whole wheat flours evaluated presented parameters recommended for bread making, according to the current classification. However, the specific volume of breads elaborated with these flours was not suitable, that is, the rheological analyses were not able to predict the specific volume of pan bread. The development of the Sehn-Steel dimensionless number allowed establishing a classification of whole wheat flours as "suitable" (Sehn-Steel dimensionless number between 62 and 200) or "unsuitable" for the production of pan bread (Sehn-Steel dimensionless number lower than 62). Moreover, an equation that can predict the specific volume of whole pan bread through this dimensionless number was developed.

  3. Improved lumped models for transient combined convective and radiative cooling of a two-layer spherical fuel element

    International Nuclear Information System (INIS)

    Silva, Alice Cunha da; Su, Jian

    2013-01-01

    The High Temperature Gas cooled Reactor (HTGR) is a fourth generation thermal nuclear reactor, graphite-moderated and helium cooled. The HTGRs have important characteristics making essential the study of these reactors, as well as its fuel element. Examples of these are: high thermal efficiency,low operating costs and construction, passive safety attributes that allow implication of the respective plants. The Pebble Bed Modular Reactor (PBMR) is a HTGR with spherical fuel elements that named the reactor. This fuel element is composed by a particulate region with spherical inclusions, the fuel UO2 particles, dispersed in a graphite matrix and a convective heat transfer by Helium happens on the outer surface of the fuel element. In this work, the transient heat conduction in a spherical fuel element of a pebble-bed high temperature reactor was studied in a transient situation of combined convective and radiative cooling. Improved lumped parameter model was developed for the transient heat conduction in the two-layer composite sphere subjected to combined convective and radiative cooling. The improved lumped model was obtained through two-point Hermite approximations for integrals. Transient combined convective and radiative cooling of the two-layer spherical fuel element was analyzed to illustrate the applicability of the proposed lumped model, with respect to die rent values of the Biot number, the radiation-conduction parameter, the dimensionless thermal contact resistance, the dimensionless inner diameter and coating thickness, and the dimensionless thermal conductivity. It was shown by comparison with numerical solution of the original distributed parameter model that the improved lumped model, with H2,1/H1,1/H0,0 approximation yielded significant improvement of average temperature prediction over the classical lumped model. (author)

  4. Prediction of Hot Tearing Using a Dimensionless Niyama Criterion

    Science.gov (United States)

    Monroe, Charles; Beckermann, Christoph

    2014-08-01

    The dimensionless form of the well-known Niyama criterion is extended to include the effect of applied strain. Under applied tensile strain, the pressure drop in the mushy zone is enhanced and pores grow beyond typical shrinkage porosity without deformation. This porosity growth can be expected to align perpendicular to the applied strain and to contribute to hot tearing. A model to capture this coupled effect of solidification shrinkage and applied strain on the mushy zone is derived. The dimensionless Niyama criterion can be used to determine the critical liquid fraction value below which porosity forms. This critical value is a function of alloy properties, solidification conditions, and strain rate. Once a dimensionless Niyama criterion value is obtained from thermal and mechanical simulation results, the corresponding shrinkage and deformation pore volume fractions can be calculated. The novelty of the proposed method lies in using the critical liquid fraction at the critical pressure drop within the mushy zone to determine the onset of hot tearing. The magnitude of pore growth due to shrinkage and deformation is plotted as a function of the dimensionless Niyama criterion for an Al-Cu alloy as an example. Furthermore, a typical hot tear "lambda"-shaped curve showing deformation pore volume as a function of alloy content is produced for two Niyama criterion values.

  5. An equation for the dimensionless friction factor of consolidated ...

    African Journals Online (AJOL)

    An equation that relates the dimensionless friction factor of a porous medium its Reynolds number, during incompressible and compressible fluid flow through the medium is proposed. The equation is a curve fit of a graph drawn from the results of Ohirhian for water (liquid) and that of Akpokene for Nitrogen (gas) flow ...

  6. Comments Simplification of thermodynamic calculations through dimensionless entropies

    International Nuclear Information System (INIS)

    Pitzer, K.S.; Brewer, L.

    1979-01-01

    The advantages of using thermodynamic quantities divided by the gas constant (H/R, G/R, etc,) in calculations are described. It is recommended that thermodynamic tables be presented in this form, so that the entries are either dimensionless or in units of kelvins

  7. Rational Solutions and Lump Solutions of the Potential YTSF Equation

    Science.gov (United States)

    Sun, Hong-Qian; Chen, Ai-Hua

    2017-07-01

    By using of the bilinear form, rational solutions and lump solutions of the potential Yu-Toda-Sasa-Fukuyama (YTSF) equation are derived. Dynamics of the fundamental lump solution, n1-order lump solutions, and N-lump solutions are studied for some special cases. We also find some interaction behaviours of solitary waves and one lump of rational solutions.

  8. Single lump breast surface stress assessment study

    Science.gov (United States)

    Vairavan, R.; Ong, N. R.; Sauli, Z.; Kirtsaeng, S.; Sakuntasathien, S.; Paitong, P.; Alcain, J. B.; Lai, S. L.; Retnasamy, V.

    2017-09-01

    Breast cancer is one of the commonest cancers diagnosed among women around the world. Simulation approach has been utilized to study, characterize and improvise detection methods for breast cancer. However, minimal simulation work has been done to evaluate the surface stress of the breast with lumps. Thus, in this work, simulation analysis was utilized to evaluate and assess the breast surface stress due to the presence of a lump within the internal structure of the breast. The simulation was conducted using the Elmer software. Simulation results have confirmed that the presence of a lump within the breast causes stress on the skin surface of the breast.

  9. Can we calculate the fundamental dimensionless constants of physics

    International Nuclear Information System (INIS)

    Barut, A.O.

    1987-07-01

    We review some dynamical models to calculate the dimensionless constants α=e 2 /4πε 0 (h/2π)c, β=M p /m e (or β'=m μ /m e ), γ=G Fermi m e 2 /c(h/2π) 3 and δ=G Newton m e 2 /(e 2 /4πε 0 ) which are associated with the four different manifestations (electromagnetic, strong, weak and gravitational) of a possible single interaction. (author). 15 refs

  10. Dimensionless parameters, scaling laws, and the implications for ETG

    Energy Technology Data Exchange (ETDEWEB)

    Castle, G.G.

    1995-04-20

    ETG will be useful in resolving several physical issues relevant to Spherical Tokamak Reactor concepts. First, it will provide a test of whether transport is Bohm or gyro-Bohm in nature. The second point is that ETG will operate in a completely different range of {rho}* space from other high performance machines, opening up a previously inaccessible region of parameter space. ETG is also a (very) high-{beta} machine. It would be the only device that would have all of its parameters except {rho}* similar to those of a Spherical tokamak Reactor. If it turns out that the transport scales definitively as either Bohm or gyro-Bohm, then extrapolation to reactor conditions with significantly lower values of {rho}* would become more credible. It is also shown that in general one cannot obtain a power law relation in the dimensionless variables for the confinement tim from a power law fit to the engineering variables. It is shown, however, that if T{sub i}/T{sub e} and n{sub i}/n{sub e} are constant or if a modified definition of certain dimensionless variables is adopted, then such a power law conversion is possible.

  11. Cytomorphological study of palpable breast lumps

    Directory of Open Access Journals (Sweden)

    PK Choudhary

    2015-09-01

    Full Text Available Background: Breast lump is a very common clinical presentation for which fine needle aspiration cytology is often sought for. Because of it’s significant diagnositic value, FNAC has become a routine tool in the evaluation of the nature of the lesion. The objective of this study was to determine the cytomorphological patterns of breast lump in eastern part of Nepal among individuals attending Nobel Medical College. Materials and Methods: This was a retrospective descriptive study done in department of pathology from December 2012 to June 2015. All individuals presenting with breast lumps was included in this study. FNAC was done as per standard procedure and categorized as per United Kingdom National Health Survey Breast Screening Programme (UK-NHS-BSP categories and further also categorized in to neoplastic and non-neolastic categories. Results: We studied 771 cases of breast lumps. Occurrence of breast lump was more common in female (97.4%. Neoplastic lesions accounted for 84.1% of cases out of which benign comprised of 94.6% and malignant comprised of 5.6%. Common benign lesions observed were that of fibroadenona (264 and fibrocystic changes (204. Ductal carcinoma was the most common malignant lesions. All malignant lesions were observed in older age and female sex population.Conclusion: Most of the cases of breast lumps are benign in nature and very few accounted for malignant cases. There is predominance of benign lesions in young age and increased malignancy in older age and female population. 

  12. Analysis of transient heat conduction in a PWR fuel rod by an improved lumped parameter approach

    Energy Technology Data Exchange (ETDEWEB)

    Dourado, Eneida Regina G. [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil); Cotta, Renato M. [Coordenacao de Pos-Graduacao e Pesquisa de Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Mecanica; Jian, Su, E-mail: eneidadourado@gmail.com, E-mail: sujian@nuclear.ufrj.br, E-mail: cotta@mecanica.ufrj.br [Coordenacao de Pos-Graduacao e Pesquisa de Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear

    2017-07-01

    This paper aims to analyze transient heat conduction in a nuclear fuel rod by an improved lumped parameter approach. One-dimensional transient heat conduction is considered, with the circumferential symmetry assumed and the axial conduction neglected. The thermal conductivity and specific heat in the fuel pellet are considered temperature dependent, while the thermophysical properties of the cladding are considered constant. Hermite approximation for integration is used to obtain the average temperature and heat flux in the radial direction. Significant improvement over the classical lumped parameter formulation has been achieved. The proposed model can be also used in dynamic analysis of PWR and nuclear power plant simulators. (author)

  13. Analysis of transient heat conduction in a PWR fuel rod by an improved lumped parameter approach

    International Nuclear Information System (INIS)

    Dourado, Eneida Regina G.; Cotta, Renato M.; Jian, Su

    2017-01-01

    This paper aims to analyze transient heat conduction in a nuclear fuel rod by an improved lumped parameter approach. One-dimensional transient heat conduction is considered, with the circumferential symmetry assumed and the axial conduction neglected. The thermal conductivity and specific heat in the fuel pellet are considered temperature dependent, while the thermophysical properties of the cladding are considered constant. Hermite approximation for integration is used to obtain the average temperature and heat flux in the radial direction. Significant improvement over the classical lumped parameter formulation has been achieved. The proposed model can be also used in dynamic analysis of PWR and nuclear power plant simulators. (author)

  14. Lumped-Parameter Models for Wind-Turbine Footings on Layered Ground

    DEFF Research Database (Denmark)

    Andersen, Lars; Liingaard, Morten

    2007-01-01

    The design of modern wind turbines is typically based on lifetime analyses using aeroelastic codes. In this regard, the impedance of the foundations must be described accurately without increasing the overall size of the computational model significantly. This may be obtained by the fitting...... of a lumped-parameter model to the results of a rigorous model or experimental results. In this paper, guidelines are given for the formulation of such lumped-parameter models and examples are given in which the models are utilised for the analysis of a wind turbine supported by a surface footing on a layered...

  15. Dimensionless Numbers Expressed in Terms of Common CVD Process Parameters

    Science.gov (United States)

    Kuczmarski, Maria A.

    1999-01-01

    A variety of dimensionless numbers related to momentum and heat transfer are useful in Chemical Vapor Deposition (CVD) analysis. These numbers are not traditionally calculated by directly using reactor operating parameters, such as temperature and pressure. In this paper, these numbers have been expressed in a form that explicitly shows their dependence upon the carrier gas, reactor geometry, and reactor operation conditions. These expressions were derived for both monatomic and diatomic gases using estimation techniques for viscosity, thermal conductivity, and heat capacity. Values calculated from these expressions compared well to previously published values. These expressions provide a relatively quick method for predicting changes in the flow patterns resulting from changes in the reactor operating conditions.

  16. Recomputing Causality Assignments on Lumped Process Models When Adding New Simplification Assumptions

    Directory of Open Access Journals (Sweden)

    Antonio Belmonte

    2018-04-01

    Full Text Available This paper presents a new algorithm for the resolution of over-constrained lumped process systems, where partial differential equations of a continuous time and space model of the system are reduced into ordinary differential equations with a finite number of parameters and where the model equations outnumber the unknown model variables. Our proposal is aimed at the study and improvement of the algorithm proposed by Hangos-Szerkenyi-Tuza. This new algorithm improves the computational cost and solves some of the internal problems of the aforementioned algorithm in its original formulation. The proposed algorithm is based on parameter relaxation that can be modified easily. It retains the necessary information of the lumped process system to reduce the time cost after introducing changes during the system formulation. It also allows adjustment of the system formulations that change its differential index between simulations.

  17. Improved lumped parameter for annular fuel element thermohydraulic analysis

    International Nuclear Information System (INIS)

    Duarte, Juliana Pacheco; Su, Jian; Alvim, Antonio Carlos Marques

    2011-01-01

    Annular fuel elements have been intensively studied for the purpose of increasing power density in light water reactors (LWR). This paper presents an improved lumped parameter model for the dynamics of a LWR core with annular fuel elements, composed of three sub-models: the fuel dynamics model, the neutronics model, and the coolant energy balance model. The transient heat conduction in radial direction is analyzed through an improved lumped parameter formulation. The Hermite approximation for integration is used to obtain the average temperature of the fuel and cladding and also to obtain the average heat flux. The volumetric heat generation in fuel rods was obtained with the point kinetics equations with six delayed neutron groups. The equations for average temperature of fuel and cladding are solved along with the point kinetic equations, assuming linear reactivity and coolant temperature in cases of reactivity insertion. The analytical development of the model and the numeric solution of the ordinary differential equation system were obtained by using Mathematica 7.0. The dynamic behaviors for average temperatures of fuel, cladding and coolant in transient events as well as the reactor power were analyzed. (author)

  18. Homeostasis and Heterostasis: from Invariant to Dimensionless Numbers

    Directory of Open Access Journals (Sweden)

    BRUNO GÜNTHER

    2003-01-01

    Full Text Available In the present paper we have examined the applicability of dimensionless and invariant numbers (DN & IN to the analysis of the cardiovascular system of mammals, whose functions were measured at standard metabolic conditions. The calculated IN did not change when we compared these figures with those obtained in dogs while they were submitted to graded exercise on a treadmill. In both instances, rest and exercise, the constancy of the IN prevailed, in accordance with Cannon's principle of "homeostasis" (1929. On the contrary, when dogs were examined during a standardized hypovolemic shock, we observed a breakdown of the IN, and the resulting DN evolved as a reliable index of the condition of "heterostasis" as defined by H. Selye. The robustness of the homeostatic regulations is based on high-gain integral feedback mechanisms, while "heterostasis" could be associated with low-gain integral feedback processes, when organisms are submitted to unitary step disturbances or to changes of the set-point at the entrance of the feedback loop.

  19. A dimensionless criterion for characterising internal transport barriers in tokamaks

    International Nuclear Information System (INIS)

    Tresset, G.; Litaudon, X.; Moreau, D.

    2000-07-01

    A simple criterion, based on a dimensionless parameter (ρ T * =ρ s /L T ) related to drift wave turbulence stabilisation and anomalous transport theory, is proposed in order to characterise the emergence and the space-time evolution of internal transport barriers (ITB's) during a tokamak discharge. The underlying physics which led us to consider the possible relevance of this parameter as a local indicator of a bifurcated plasma state is the breaking of the gyro-Bohm turbulence scaling by the diamagnetic velocity shear, which has been observed in various numerical simulations [e.g. X. Garbet and R.E. Waltz, Phys. Plasmas 3(1996) 1898]. The presence of an ITB is inferred when ρ T * exceeds a threshold value. The main features like the emergence time, location and even dynamics of ITB's can then be summarized on a single graphical representation consistent with measurement uncertainties. The validity of such a criterion is demonstrated on the Optimized Shear (OS) database of JET in several experimental configurations. Large database analysis and realtime control of OS discharges are envisaged as the most attractive applications. (author)

  20. Experimental constraints on transport from dimensionless parameter scaling studies

    International Nuclear Information System (INIS)

    Petty, C.C.; Luce, T.C.; Baker, D.R.

    1998-02-01

    The scalings of heat transport with safety factor (q), normalized collisionality (v), plasma beta (β), and relative gyroradius (ρ*) have been measured on the DIII-D tokamak. The measured ρ* β and v scalings of heat transport indicate that E x B transport from drive wave turbulence is a plausible basis for anomalous transport. For high confinement (H) mode plasmas where the safety factor was varied at fixed magnetic shear, the effective (or one-fluid) thermal diffusivity was found to scale like χ eff ∝ q 2.3±0.64 , with the ion and electron fluids having the same q scaling to within the experimental errors except near the plasma edge. The scaling of the thermal confinement time with safety factor was in good agreement with this local transport dependence, τ th ∝ q -2.42±0.31 ; however, when the magnetic shear was allowed to vary to keep q 0 fixed during the (edge) safety factor scan, a weaker global dependence was observed, τ th ∝ q 95 -1.43±0.23 . This weaker dependence was mainly due to the change in the local value of q between the two types of scans. The combined ρ*, β, v and q scalings of heat transport for H-mode plasmas on DIII-D reproduce the empirical confinement scaling using physical (dimensionless) parameters with the exception of weaker power degradation

  1. A dimensionless parameter for classifying hemodynamics in intracranial

    Science.gov (United States)

    Asgharzadeh, Hafez; Borazjani, Iman

    2015-11-01

    Rupture of an intracranial aneurysm (IA) is a disease with high rates of mortality. Given the risk associated with the aneurysm surgery, quantifying the likelihood of aneurysm rupture is essential. There are many risk factors that could be implicated in the rupture of an aneurysm. However, the most important factors correlated to the IA rupture are hemodynamic factors such as wall shear stress (WSS) and oscillatory shear index (OSI) which are affected by the IA flows. Here, we carry out three-dimensional high resolution simulations on representative IA models with simple geometries to test a dimensionless number (first proposed by Le et al., ASME J Biomech Eng, 2010), denoted as An number, to classify the flow mode. An number is defined as the ratio of the time takes the parent artery flow transports across the IA neck to the time required for vortex ring formation. Based on the definition, the flow mode is vortex if An>1 and it is cavity if AnOSI on the human subject IA. This work was supported partly by the NIH grant R03EB014860, and the computational resources were partly provided by CCR at UB. We thank Prof. Hui Meng and Dr. Jianping Xiang for providing us the database of aneurysms and helpful discussions.

  2. Application of lumped-parameter models

    DEFF Research Database (Denmark)

    Ibsen, Lars Bo; Liingaard, Morten

    This technical report concerns the lumped-parameter models for a suction caisson with a ratio between skirt length and foundation diameter equal to 1/2, embedded into an viscoelastic soil. The models are presented for three different values of the shear modulus of the subsoil (section 1.1). Subse...

  3. Advanced control of liquid water region in diffusion media of polymer electrolyte fuel cells through a dimensionless number

    Science.gov (United States)

    Wang, Yun; Chen, Ken S.

    2016-05-01

    In the present work, a three-dimension (3-D) model of polymer electrolyte fuel cells (PEFCs) is employed to investigate the complex, non-isothermal, two-phase flow in the gas diffusion layer (GDL). Phase change in gas flow channels is explained, and a simplified approach accounting for phase change is incorporated into the fuel cell model. It is found that the liquid water contours in the GDL are similar along flow channels when the channels are subject to two-phase flow. Analysis is performed on a dimensionless parameter Da0 introduced in our previous paper [Y. Wang and K. S. Chen, Chemical Engineering Science 66 (2011) 3557-3567] and the parameter is further evaluated in a realistic fuel cell. We found that the GDL's liquid water (or liquid-free) region is determined by the Da0 number which lumps several parameters, including the thermal conductivity and operating temperature. By adjusting these factors, a liquid-free GDL zone can be created even though the channel stream is two-phase flow. Such a liquid-free zone is adjacent to the two-phase region, benefiting local water management, namely avoiding both severe flooding and dryness.

  4. Subtidal hydrodynamics in a tropical lagoon: A dimensionless numbers approach

    Science.gov (United States)

    Tenorio-Fernandez, L.; Valle-Levinson, A.; Gomez-Valdes, J.

    2018-01-01

    Observations in a tropical lagoon of the Yucatan peninsula motivated a non-dimensional number analysis to examine the relative influence of tidal stress, density gradients and wind stress on subtidal hydrodynamics. A two-month observation period in Chelem Lagoon covered the transition from the dry to the wet season. Chelem Lagoon is influenced by groundwater inputs and exhibits a main sub-basin (central sub-basin), a west sub-basin and an east sub-basin. Subtidal hydrodynamics were associated with horizontal density gradients that were modified seasonally by evaporation, precipitation, and groundwater discharge. A tidal Froude number (Fr0), a Wedderburn number (W), and a Stress ratio (S0) were used to diagnose the relative importance of dominant subtidal driving forces. The Froude number (Fr0) compares tidal forcing and baroclinic forcing through the ratio of tidal stress to longitudinal baroclinic pressure gradient. The Wedderburn number (W) relates wind stress to baroclinicity. The stress ratio (S0) sizes tidal stress and wind stress. S0 is a new diagnostic tool for systems influenced by tides and winds, and represents the main contribution of this research. Results show that spring-tide subtidal flows in the tropical lagoon had log(Fr0) ≫ 0 and log(S0) > 0 , i.e., driven mainly by tidal stresses (advective accelerations). Neap tides showed log(Fr0) ≪ 0 and log(S0) < 0) , i.e., flows driven by baroclinicity, especially at the lagoon heads of the east and west sub-basins. However, when the wind stress intensified over the lagoon, the relative importance of baroclinicity decreased and the wind stress controlled the dynamics (log(W) ≫ 0). Each sub-basin exhibited a different subtidal response, according to the dimensionless numbers. The response depended on the fortnightly tidal cycle, the location and magnitude of groundwater input, and the direction and magnitude of the wind stress.

  5. 7 CFR 1726.205 - Multiparty lump sum quotations.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Multiparty lump sum quotations. 1726.205 Section 1726....205 Multiparty lump sum quotations. The borrower or its engineer must contact a sufficient number of... basis of written lump sum quotations, the borrower will select the supplier or contractor based on the...

  6. Lumped parameter modeling of a two-phase thermal-hydraulic channel with interface tracking

    International Nuclear Information System (INIS)

    Jo, J.H.; Kaufman, J.M.; Ruger, C.J.; Stein, S.

    1978-01-01

    A nonhomogenous, thermal nonequilibrium model for one-dimensional two-phase flow in a heated channel has been formulated in lumped parameter form. The channel is divided into a variable number of flow regimes separated by moving interfaces. The model can be used to predict the behavior of a LWR core and both primary and secondary sides of a steam generator under transient conditions. (author)

  7. The lumped parameter model for fuel pins

    Energy Technology Data Exchange (ETDEWEB)

    Liu, W S [Ontario Hydro, Toronto, ON (Canada)

    1996-12-31

    The use of a lumped fuel-pin model in a thermal-hydraulic code is advantageous because of computational simplicity and efficiency. The model uses an averaging approach over the fuel cross section and makes some simplifying assumptions to describe the transient equations for the averaged fuel, fuel centerline and sheath temperatures. It is shown that by introducing a factor in the effective fuel conductivity, the analytical solution of the mean fuel temperature can be modified to simulate the effects of the flux depression in the heat generation rate and the variation in fuel thermal conductivity. The simplified analytical method used in the transient equation is presented. The accuracy of the lumped parameter model has been compared with the results from the finite difference method. (author). 4 refs., 2 tabs., 4 figs.

  8. Dark lump excitations in superfluid Fermi gases

    Science.gov (United States)

    Xu, Yan-Xia; Duan, Wen-Shan

    2012-11-01

    We study the linear and nonlinear properties of two-dimensional matter-wave pulses in disk-shaped superfluid Fermi gases. A Kadomtsev—Petviashvili I (KPI) solitary wave has been realized for superfluid Fermi gases in the limited cases of Bardeen—Cooper—Schrieffer (BCS) regime, Bose—Einstein condensate (BEC) regime, and unitarity regime. One-lump solution as well as one-line soliton solutions for the KPI equation are obtained, and two-line soliton solutions with the same amplitude are also studied in the limited cases. The dependence of the lump propagating velocity and the sound speed of two-dimensional superfluid Fermi gases on the interaction parameter are investigated for the limited cases of BEC and unitarity.

  9. Dark lump excitations in superfluid Fermi gases

    International Nuclear Information System (INIS)

    Xu Yan-Xia; Duan Wen-Shan

    2012-01-01

    We study the linear and nonlinear properties of two-dimensional matter-wave pulses in disk-shaped superfluid Fermi gases. A Kadomtsev—Petviashvili I (KPI) solitary wave has been realized for superfluid Fermi gases in the limited cases of Bardeen—Cooper—Schrieffer (BCS) regime, Bose—Einstein condensate (BEC) regime, and unitarity regime. One-lump solution as well as one-line soliton solutions for the KPI equation are obtained, and two-line soliton solutions with the same amplitude are also studied in the limited cases. The dependence of the lump propagating velocity and the sound speed of two-dimensional superfluid Fermi gases on the interaction parameter are investigated for the limited cases of BEC and unitarity

  10. A lumped parameter model of plasma focus

    International Nuclear Information System (INIS)

    Gonzalez, Jose H.; Florido, Pablo C.; Bruzzone, H.; Clausse, Alejandro

    1999-01-01

    A lumped parameter model to estimate neutron emission of a plasma focus (PF) device is developed. The dynamic of the current sheet is calculated using a snowplow model, and the neutron production with the thermal fusion cross section for a deuterium filling gas. The results were contrasted as a function of the filling pressure with experimental measurements of a 3.68 KJ Mather-type PF. (author)

  11. Optimization of rhombic drive mechanism used in beta-type Stirling engine based on dimensionless analysis

    International Nuclear Information System (INIS)

    Cheng, Chin-Hsiang; Yang, Hang-Suin

    2014-01-01

    In the present study, optimization of rhombic drive mechanism used in a beta-type Stirling engine is performed based on a dimensionless theoretical model toward maximization of shaft work output. Displacements of the piston and the displacer with the rhombic drive mechanism and variations of volumes and pressure in the chambers of the engine are firstly expressed in dimensionless form. Secondly, Schmidt analysis is incorporated with Senft's shaft work theory to build a dimensionless thermodynamic model, which is employed to yield the dimensionless shaft work. The dimensionless model is verified with experimental data. It is found that the relative error between the experimental and the theoretical data in dimensionless shaft work is lower than 5.2%. This model is also employed to investigate the effects of the influential geometric parameters on the shaft work, and the optimization of these parameters is attempted. Eventually, design charts that help design the optimal geometry of the rhombic drive mechanism are presented in this report. - Highlights: • Specifically dealing with optimization of rhombic-drive mechanism used in Stirling engine based on dimensionless model. • Propose design charts that help determine the optimal geometric parameters of the rhombic drive mechanism. • Complete study of influential factors affecting the shaft work output

  12. Patterns in new dimensionless quantities containing melting temperature, and their dependence on pressure

    Directory of Open Access Journals (Sweden)

    U. WALZER

    1980-06-01

    Full Text Available The relationships existing between melting temperature and other
    macroscopic physical quantities are investigated. A new dimensionless
    quantity Q(1 not containing the Grtineisen parameter proves to be suited for serving in future studies as a tool for the determination of the melting temperature in the outer core of the Earth. The pressure dependence of more general dimensionless quantities Q„ is determined analytically and, for the chemical elements, numerically, too. The patterns of various interesting dimensionless quantities are shown in the Periodic Table and compared.

  13. Lumped elements for RF and microwave circuits

    CERN Document Server

    Bahl, Inder

    2003-01-01

    Due to the unprecedented growth in wireless applications over the past decade, development of low-cost solutions for RF and microwave communication systems has become of great importance. This practical new book is the first comprehensive treatment of lumped elements, which are playing a critical role in the development of the circuits that make these cost-effective systems possible. The books offers you an in-depth understanding of the different types of RF and microwave circuit elements, including inductors, capacitors, resistors, transformers, via holes, airbridges, and crossovers. Support

  14. Importance theory for lumped-parameter systems

    International Nuclear Information System (INIS)

    Cady, K.B.; Kenton, M.A.; Ward, J.C.; Piepho, M.G.

    1981-01-01

    A general sensitivity theory has been developed for nonlinear lumped parameter system simulations. The point of departure is general perturbation theory for nonlinear systems. Importance theory as developed here allows the calculation of the sensitivity of a response function to any physical or design parameter; importance of any equation or term or physical effect in the system model on the response function; variance of the response function caused by the variances and covariances of all physical parameters; and approximate effect on the response function of missing physical phenomena or incorrect parameters

  15. The role of men in early detection of their spouses' breast lump(s ...

    African Journals Online (AJOL)

    We aim to determine whether men can be of help in the early detection of lumps in their spouses' breast. 230 questionnaires were administered to married men. The responses were accepted as “yes” or “no. 217 men (94.35%) responded. 195 (89.86%) were aware of breast cancer. 212 ( 97.7%) were either Christians or ...

  16. Use of Lump Parameter Codes at SNSA

    International Nuclear Information System (INIS)

    Muehleisen, A.

    2006-01-01

    The lump parameter codes are due to the specifics of Slovenian regulation used only in a very limited scope by the SNSA itself. The law requires that most of the analysis needed for regulatory decision making have to be performed by technical support organisations (TSOs). The use of lump parameter codes is therefore limited to the amount needed to maintain necessary technical competence and to support, to a degree, the reasoning for raising new issues and methodologies. SNSA has available its own NPP MELCOR model and uses for its own purposes NPP Krsko RELAP model. RELAP model is also part of the SNSA NPA analyser. Here presented recent uses at SNSA include use of NPA in support of a project, aimed at estimating maturity and uses of CFD codes for regulatory purposes, transition from MELCOR 1.8.3 to 1.8.5 model and its validation, developing MELCOR PAR model and use of NPA for training purposes. NPA use in support of investigation of CFD usability has been in performing lump parameter code calculation against which the CFD results could be compared. The case of SI injection and the following boron distribution in the reactor vessel has been used for this purpose. The comparison showed that for the particular case there is no urgent need for CFD code calculations, nevertheless the project clearly demonstrated wealth of additional information that can be gained by the use of CFD code. As far as MELCOR model is concerned, only transition of the model to the newer code version has been performed and PAR input prepared and tested. Even though there is a feeling at SNSA that some preliminary analysis with it (such as analysis of typical accidents with PARs present and analysis in support of wet cavity modification) would be useful as a support for decision making as well as for simple training purposes we have not been able to perform them due to other priorities and lack of human resources. SNSA is additionally tasked with support to TSOs in their efforts to maintain and

  17. Management of breast lumps in Maiduguri, Nigeria

    Directory of Open Access Journals (Sweden)

    Ali Nuhu

    2014-01-01

    Full Text Available Background: Reported changes in the demography, modes of presentation and histological variants of tumors of the breast have been published in developed and some developing countries. Although benign lesions have persistently accounted for most breast tumors, the incidence of malignant breast lesion in young women in sub-Saharan Africa has been disturbingly high. We reviewed the demographics, pattern and management of breast lumps excised at University of Maiduguri Teaching Hospital (UMTH over a 6 year period. Patients and Methods: A retrospective study of patients with breast lumps at UMTH was carried out between January 2005 and December 2010. Details of their bio-data, clinical, and histopathology details were analyzed using descriptive statistics. Results: A total of 913 patients, comprising 887 females (97.2% and 26 males (2.8% were reviewed. The mean age was 33.1 ± 14.6 years (range: 12-80 years and the mean duration of symptoms was 8 ± 2.14 months (range: 2-23 months. 359 (39.3% were malignant and 577 (63.2% were benign. The mean ages of women and men with invasive carcinomas of the breast were 45.58 ± 13.22 and 49.75 ± 18.28 years, respectively. The mean age of women with benign breast disease was 28.4 ± 10.0 for fibrocystic disease and 21.8 ± 5.31 years for fibroadenoma. Mode of presentations included ulcers (8.7%, axillary lymph node enlargement (30.0%, nipple discharge (13.0% and breast pain (21.7%. The most common histological diagnoses were carcinoma of the breast, N = 340 (37.2%, fibroadenoma, N = 276 (30.2% and fibrocystic disease, N = 199 (21.8%. The least common pathology was tuberculosis of the breast, N = 6; (0.7%. Conclusion: Though benign diseases are still more common, a high percentage of breast lumps in Maiduguri are due to malignant disease and this is frequent in younger women.

  18. The liquid lift: Looking natural without lumps

    Directory of Open Access Journals (Sweden)

    Iñigo de Felipe

    2015-01-01

    Full Text Available Context: Hyaluronic acid (HA is the most common filler used to rejuvenate. Today, a three-dimensional approach prevails over previous techniques in which this material was used in specific areas of the face such as the nasolabial fold, the marionette line, and the eye trough giving a strange appearance that does not look natural. Even with a volumizing purpose, the injection of HA can sometimes produce clinically detectable nodules or lumps where the filler is deposited. Aims: To develop a new technique of injecting HA that can provide more natural results and avoid the lumpiness and nodular appearance that sometimes occurs with the injection of HA. To detect whether mixing HA with diluted anesthetic agent modifies its behavior. Settings and Design: Prospective, case control, single-center study on a private clinic setting. Materials and Methods: Eighty six patients were enrolled in this study. All of them had a previous treatment with nondiluted HA using a needle at least a year before. Patients were injected with 8 mL of reticulated HA (RHA mixed with 6 mL of saline and 2 mL of anesthetic agent. The mixture was administered through a cannula inserted in the face, one at mid-cheek and another at frontal-temporal point of entry. Owing to the lifting effect of this mixture we called this procedure liquid lift (LL. Patients were evaluated 1 month, 6 months, and a year later and asked to compare the LL with previous experiences in terms of natural look, pain, and appearance of nodules. Statistical Analysis Used: Student′s t-test. Results: One month after the treatment, 83 out of 86 patients (96.5% thought LL produced a more natural look than the previous treatment with the needle. Sixty two (72% considered LL less painful than the previous treatment and only eight (9.3% could detect lumps or nodules 1 month after LL was performed compared with 46 (53.5% that described this problem with previous needle injections. The incidence of bruising was

  19. 28 CFR 523.16 - Lump sum awards.

    Science.gov (United States)

    2010-07-01

    ... satisfactory performance of an unusually hazardous assignment; (c) An act which protects the lives of staff or... TRANSFER COMPUTATION OF SENTENCE Extra Good Time § 523.16 Lump sum awards. Any staff member may recommend... award is calculated. No seniority is accrued for such awards. Staff may recommend lump sum awards of...

  20. Dimensionless Analysis for Designing Domestic Rainwater Harvesting Systems at the Regional Level in Northern Taiwan

    Directory of Open Access Journals (Sweden)

    Chao-Hsien Liaw

    2014-12-01

    Full Text Available A regional-level and dimensionless analysis for designing a domestic rainwater harvesting system (DRWHS was developed. To consider various combinations of water demand, storage capacity, effective roof area, and rainfall in DRWHS design, two dimensionless ratios were used, namely, demand fraction and storage fraction, along with a relationship between the two ratios. Firstly, Northern Taiwan was divided into four sub-regions through cluster analysis based on the average annual 10-day rainfall distribution at rainfall stations and administrative districts. Easy-to-use dimensionless curves between demand fraction and storage fraction were obtained for five rainwater supply reliabilities of the DRWHS for the four sub-regions. Based on the dimensionless curves, a nomogram was constructed for designing DRWHSs at a rainwater supply reliability of 95% in the sub-region I. Storage capacities determined from the dimensionless curves showed a close fit with those determined from simulated values, but were larger than the values estimated from the method presented in the Green Building Evaluation Manual in most situations. The methodology developed herein can be used effectively for the preliminary design of a DRWHS and for overcoming the difficulties faced in designing a DRWHS without rainfall data and with incomplete rainfall data.

  1. lumpGEM: Systematic generation of subnetworks and elementally balanced lumped reactions for the biosynthesis of target metabolites.

    Directory of Open Access Journals (Sweden)

    Meric Ataman

    2017-07-01

    Full Text Available In the post-genomic era, Genome-scale metabolic networks (GEMs have emerged as invaluable tools to understand metabolic capabilities of organisms. Different parts of these metabolic networks are defined as subsystems/pathways, which are sets of functional roles to implement a specific biological process or structural complex, such as glycolysis and TCA cycle. Subsystem/pathway definition is also employed to delineate the biosynthetic routes that produce biomass building blocks. In databases, such as MetaCyc and SEED, these representations are composed of linear routes from precursors to target biomass building blocks. However, this approach cannot capture the nested, complex nature of GEMs. Here we implemented an algorithm, lumpGEM, which generates biosynthetic subnetworks composed of reactions that can synthesize a target metabolite from a set of defined core precursor metabolites. lumpGEM captures balanced subnetworks, which account for the fate of all metabolites along the synthesis routes, thus encapsulating reactions from various subsystems/pathways to balance these metabolites in the metabolic network. Moreover, lumpGEM collapses these subnetworks into elementally balanced lumped reactions that specify the cost of all precursor metabolites and cofactors. It also generates alternative subnetworks and lumped reactions for the same metabolite, accounting for the flexibility of organisms. lumpGEM is applicable to any GEM and any target metabolite defined in the network. Lumped reactions generated by lumpGEM can be also used to generate properly balanced reduced core metabolic models.

  2. MEMS 3-DoF gyroscope design, modeling and simulation through equivalent circuit lumped parameter model

    International Nuclear Information System (INIS)

    Mian, Muhammad Umer; Khir, M. H. Md.; Tang, T. B.; Dennis, John Ojur; Riaz, Kashif; Iqbal, Abid; Bazaz, Shafaat A.

    2015-01-01

    Pre-fabrication, behavioural and performance analysis with computer aided design (CAD) tools is a common and fabrication cost effective practice. In light of this we present a simulation methodology for a dual-mass oscillator based 3 Degree of Freedom (3-DoF) MEMS gyroscope. 3-DoF Gyroscope is modeled through lumped parameter models using equivalent circuit elements. These equivalent circuits consist of elementary components which are counterpart of their respective mechanical components, used to design and fabricate 3-DoF MEMS gyroscope. Complete designing of equivalent circuit model, mathematical modeling and simulation are being presented in this paper. Behaviors of the equivalent lumped models derived for the proposed device design are simulated in MEMSPRO T-SPICE software. Simulations are carried out with the design specifications following design rules of the MetalMUMPS fabrication process. Drive mass resonant frequencies simulated by this technique are 1.59 kHz and 2.05 kHz respectively, which are close to the resonant frequencies found by the analytical formulation of the gyroscope. The lumped equivalent circuit modeling technique proved to be a time efficient modeling technique for the analysis of complex MEMS devices like 3-DoF gyroscopes. The technique proves to be an alternative approach to the complex and time consuming couple field analysis Finite Element Analysis (FEA) previously used

  3. MEMS 3-DoF gyroscope design, modeling and simulation through equivalent circuit lumped parameter model

    Energy Technology Data Exchange (ETDEWEB)

    Mian, Muhammad Umer, E-mail: umermian@gmail.com; Khir, M. H. Md.; Tang, T. B. [Department of Electrical and Electronic Engineering, Universiti Teknologi PETRONAS, Tronoh, Perak (Malaysia); Dennis, John Ojur [Department of Fundamental & Applied Sciences, Universiti Teknologi PETRONAS, Tronoh, Perak (Malaysia); Riaz, Kashif; Iqbal, Abid [Faculty of Electronics Engineering, GIK Institute of Engineering Sciences and Technology, Topi, Khyber Pakhtunkhaw (Pakistan); Bazaz, Shafaat A. [Department of Computer Science, Center for Advance Studies in Engineering, Islamabad (Pakistan)

    2015-07-22

    Pre-fabrication, behavioural and performance analysis with computer aided design (CAD) tools is a common and fabrication cost effective practice. In light of this we present a simulation methodology for a dual-mass oscillator based 3 Degree of Freedom (3-DoF) MEMS gyroscope. 3-DoF Gyroscope is modeled through lumped parameter models using equivalent circuit elements. These equivalent circuits consist of elementary components which are counterpart of their respective mechanical components, used to design and fabricate 3-DoF MEMS gyroscope. Complete designing of equivalent circuit model, mathematical modeling and simulation are being presented in this paper. Behaviors of the equivalent lumped models derived for the proposed device design are simulated in MEMSPRO T-SPICE software. Simulations are carried out with the design specifications following design rules of the MetalMUMPS fabrication process. Drive mass resonant frequencies simulated by this technique are 1.59 kHz and 2.05 kHz respectively, which are close to the resonant frequencies found by the analytical formulation of the gyroscope. The lumped equivalent circuit modeling technique proved to be a time efficient modeling technique for the analysis of complex MEMS devices like 3-DoF gyroscopes. The technique proves to be an alternative approach to the complex and time consuming couple field analysis Finite Element Analysis (FEA) previously used.

  4. Decay of Kadomtsev-Petviashvili lumps in dissipative media

    Science.gov (United States)

    Clarke, S.; Gorshkov, K.; Grimshaw, R.; Stepanyants, Y.

    2018-03-01

    The decay of Kadomtsev-Petviashvili lumps is considered for a few typical dissipations-Rayleigh dissipation, Reynolds dissipation, Landau damping, Chezy bottom friction, viscous dissipation in the laminar boundary layer, and radiative losses caused by large-scale dispersion. It is shown that the straight-line motion of lumps is unstable under the influence of dissipation. The lump trajectories are calculated for two most typical models of dissipation-the Rayleigh and Reynolds dissipations. A comparison of analytical results obtained within the framework of asymptotic theory with the direct numerical calculations of the Kadomtsev-Petviashvili equation is presented. Good agreement between the theoretical and numerical results is obtained.

  5. Analysis and design of lumped element Marchand baluns

    DEFF Research Database (Denmark)

    Johansen, Tom Keinicke; Krozer, Viktor

    2008-01-01

    In this paper a novel design procedure for lumped element Marchand baluns is proposed. An analysis is performed on the balun structure in order to determine the conditions for ideal balun performance in terms of the lumped element values. The analysis is verified by two broadband designs centered...... around 22.75 GHz and differing only in terms of their impedance transformation ratio. EM simulation results on our proposed lumped element Marchand balun structure predicts an insertion loss of 4 dB and return loss of 40 dB at the design frequency of 22.75 GHz. The amplitude and phase imbalance...

  6. Black holes as lumps of fluid

    International Nuclear Information System (INIS)

    Caldarelli, Marco M.; Dias, Oscar J.C.; Emparan, Roberto; Klemm, Dietmar

    2009-01-01

    The old suggestive observation that black holes often resemble lumps of fluid has recently been taken beyond the level of an analogy to a precise duality. We investigate aspects of this duality, and in particular clarify the relation between area minimization of the fluid vs. area maximization of the black hole horizon, and the connection between surface tension and curvature of the fluid, and surface gravity of the black hole. We also argue that the Rayleigh-Plateau instability in a fluid tube is the holographic dual of the Gregory-Laflamme instability of a black string. Associated with this fluid instability there is a rich variety of phases of fluid solutions that we study in detail, including in particular the effects of rotation. We compare them against the known results for asymptotically flat black holes finding remarkable agreement. Furthermore, we use our fluid results to discuss the unknown features of the gravitational system. Finally, we make some observations that suggest that asymptotically flat black holes may admit a fluid description in the limit of large number of dimensions.

  7. A distributed lumped active all-pass network configuration.

    Science.gov (United States)

    Huelsman, L. P.; Raghunath, S.

    1972-01-01

    In this correspondence a new and interesting distributed lumped active network configuration that realizes an all-pass network function is described. A design chart for determining the values of the network elements is included.

  8. Lump solutions to the Kadomtsev–Petviashvili equation

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Wen-Xiu, E-mail: mawx@cas.usf.edu

    2015-09-25

    Through symbolic computation with Maple, a class of lump solutions, rationally localized in all directions in the space, to the (2 + 1)-dimensional Kadomtsev–Petviashvili (KP) equation is presented, making use of its Hirota bilinear form. The resulting lump solutions contain six free parameters, two of which are due to the translation invariance of the KP equation and the other four of which satisfy a non-zero determinant condition guaranteeing analyticity and rational localization of the solutions. Three contour plots with different determinant values are sequentially made to show that the corresponding lump solution tends to zero when the determinant approaches zero. Two particular lump solutions with specific values of the involved parameters are plotted, as illustrative examples. - Highlights: • Positive quadratic function solutions. • Solitons rationally-localized in all directions in the space. • Solving systems of nonlinear algebraic equations by symbolic computation with Maple.

  9. Aggressive angiomyxoma presenting with huge abdominal lump: A case report

    Science.gov (United States)

    Kumar, Sanjeev; Agrawal, Nikhil; Khanna, Rahul; Khanna, AK

    2008-01-01

    Agressive angiomyxoma is a rare mesenchymal neoplasm. It mainly presents in females. We here present a case of angiomyxoma presenting as huge abdominal lump along with gluteal swelling. Case note is described along with brief review of literature. PMID:18755035

  10. Theoretical investigation of the upper and lower bounds of a generalized dimensionless bearing health indicator

    Science.gov (United States)

    Wang, Dong; Tsui, Kwok-Leung

    2018-01-01

    Bearing-supported shafts are widely used in various machines. Due to harsh working environments, bearing performance degrades over time. To prevent unexpected bearing failures and accidents, bearing performance degradation assessment becomes an emerging topic in recent years. Bearing performance degradation assessment aims to evaluate the current health condition of a bearing through a bearing health indicator. In the past years, many signal processing and data mining based methods were proposed to construct bearing health indicators. However, the upper and lower bounds of these bearing health indicators were not theoretically calculated and they strongly depended on historical bearing data including normal and failure data. Besides, most health indicators are dimensional, which connotes that these health indicators are prone to be affected by varying operating conditions, such as varying speeds and loads. In this paper, based on the principle of squared envelope analysis, we focus on theoretical investigation of bearing performance degradation assessment in the case of additive Gaussian noises, including distribution establishment of squared envelope, construction of a generalized dimensionless bearing health indicator, and mathematical calculation of the upper and lower bounds of the generalized dimensionless bearing health indicator. Then, analyses of simulated and real bearing run to failure data are used as two case studies to illustrate how the generalized dimensionless health indicator works and demonstrate its effectiveness in bearing performance degradation assessment. Results show that squared envelope follows a noncentral chi-square distribution and the upper and lower bounds of the generalized dimensionless health indicator can be mathematically established. Moreover, the generalized dimensionless health indicator is sensitive to an incipient bearing defect in the process of bearing performance degradation.

  11. Rutting resistance of asphalt mixture with cup lumps modified binder

    Science.gov (United States)

    Shaffie, E.; Hanif, W. M. M. Wan; Arshad, A. K.; Hashim, W.

    2017-11-01

    Rutting is the most common pavement distress in pavement structures which occurs mainly due to several factors such as increasing of traffic volume, climatic conditions and also due to construction design errors. This failure reduced the service life of the pavement, reduced driver safety and increase cost of maintenance. Polymer Modified Binder has been observed for a long time in improving asphalt pavement performance. Research shows that the use of polymer in bituminous mix not only improve the resistance to rutting but also increase the life span of the pavement. This research evaluates the physical properties and rutting performance of dense graded Superpave-designed HMA mix. Two different types of dense graded Superpave HMA mix were developed consists of unmodified binder mix (UMB) and cup lumps rubber (liquid form) modified binder mix (CLMB). Natural rubber polymer modified binder was prepared from addition of 8 percent of cup lumps into binder. Results showed that all the mixes passed the Superpave volumetric properties criteria which indicate that these mixtures were good with respect to durability and flexibility. Furthermore, rutting results from APA rutting test was determined to evaluate the performance of these mixtures. The rutting result of CLMB demonstrates better resistance to rutting than those prepared using UMB mix. Addition of cup lumps rubber in asphalt mixture was found to be significant, where the cup lumps rubber has certainly improves the binder properties and enhanced its rutting resistance due to greater elasticity offered by the cup lumps rubber particles. It shows that the use of cup lumps rubber can significantly reduce the rut depth of asphalt mixture by 41% compared to the minimum rut depth obtained for the UMB mix. Therefore, it can be concluded that the cup lumps rubber is suitable to be used as a modifier to modified binder in order to enhance the properties of the binder and thus improves the performance of asphalt mixes.

  12. A dimensionless approach for the runoff peak assessment: effects of the rainfall event structure

    Science.gov (United States)

    Gnecco, Ilaria; Palla, Anna; La Barbera, Paolo

    2018-02-01

    The present paper proposes a dimensionless analytical framework to investigate the impact of the rainfall event structure on the hydrograph peak. To this end a methodology to describe the rainfall event structure is proposed based on the similarity with the depth-duration-frequency (DDF) curves. The rainfall input consists of a constant hyetograph where all the possible outcomes in the sample space of the rainfall structures can be condensed. Soil abstractions are modelled using the Soil Conservation Service method and the instantaneous unit hydrograph theory is undertaken to determine the dimensionless form of the hydrograph; the two-parameter gamma distribution is selected to test the proposed methodology. The dimensionless approach is introduced in order to implement the analytical framework to any study case (i.e. natural catchment) for which the model assumptions are valid (i.e. linear causative and time-invariant system). A set of analytical expressions are derived in the case of a constant-intensity hyetograph to assess the maximum runoff peak with respect to a given rainfall event structure irrespective of the specific catchment (such as the return period associated with the reference rainfall event). Looking at the results, the curve of the maximum values of the runoff peak reveals a local minimum point corresponding to the design hyetograph derived according to the statistical DDF curve. A specific catchment application is discussed in order to point out the dimensionless procedure implications and to provide some numerical examples of the rainfall structures with respect to observed rainfall events; finally their effects on the hydrograph peak are examined.

  13. Development of Dimensionless Index Assessing Low Impact Development in Urban Areas

    Science.gov (United States)

    Jun, S. H.; Lee, E. H.; Kim, J. H.

    2017-12-01

    Because the rapid urbanization and industrialization have increased the impervious area of watersheds, inundation in urban area and water pollution of river by non-point pollutants have caused serious problems for a long time. Low Impact Development (LID) techniques have been implemented for the solution of these problems due to its cost effectiveness for mitigating the water quality and quantity impact on urban areas. There have been many studies about the effectiveness of LID, but there is a lack of research on developing an index for the assessment of LID performance. In this study, the dimensionless reliability index of LID is proposed. The index is developed using Distance Measure Method (DMM). DMM is used to consider the parameters that have different units. The parameters for reliability of LID are the amount of pollutant at the outfall and the flooding volume. Both parameters become dimensionless index by DMM. Weighted factors in dimensionless index are considered to realize the behavior of reliability for the variation of importance to the parameters. LID is applied to an actual area called Gasan city in Seoul, South Korea where inundation is frequently occurred. The reliability is estimated for 16 different rainfall events. For each rainfall event, the parameters with LID installation are compared with those of no LID installation. Depending on which parameter is considered more important, the results showed difference. In conclusion, the optimal locations of LID are suggested as the weighted factors change.

  14. Rigorous theoretical derivation of lumped models to transmission line systems

    International Nuclear Information System (INIS)

    Zhao Jixiang

    2012-01-01

    By virtue of the negative electric parameter concept, i.e. negative lumped resistance, inductance, conductance and capacitance (N-RLGC), the lumped equivalent models of transmission line systems, including the circuit model, two-port π-network and T-network, are given. We start from the N-segment-ladder-like equivalent networks composed distributed parameters, and achieve the input impedance in the form of a continued fraction. Utilizing the continued fraction theory, the expressions of input impedance are obtained under three kinds of extreme cases, i.e. the load impedances are equal to zero, infinity and characteristic impedance, respectively. When the number of segment N is limited to infinity, they are transformed to lumped elements. Comparison between the distributed model and lumped model of transmission lines, the expression of tanh γd, which is the key term in the transmission line equations, are obtained by RLGC, furthermore, according to input admittance, admittance matrix and ABCD matrix of transmission lines, the lumped equivalent circuit models, π-networks and T-networks have been given. The models are verified in the frequency and time domain, respectively, showing that the models are accurate and efficient. (semiconductor integrated circuits)

  15. Application of Mass Lumped Higher Order Finite Elements

    International Nuclear Information System (INIS)

    J. Chen, H.R. Strauss, S.C. Jardin, W. Park, L.E. Sugiyama, G. Fu, J. Breslau

    2005-01-01

    There are many interesting phenomena in extended-MHD such as anisotropic transport, mhd, 2-fluid effects stellarator and hot particles. Any one of them challenges numerical analysts, and researchers are seeking for higher order methods, such as higher order finite difference, higher order finite elements and hp/spectral elements. It is true that these methods give more accurate solution than their linear counterparts. However, numerically they are prohibitively expensive. Here we give a successful solution of this conflict by applying mass lumped higher order finite elements. This type of elements not only keep second/third order accuracy but also scale closely to linear elements by doing mass lumping. This is especially true for second order lump elements. Full M3D and anisotropic transport models are studied

  16. Lumped parameter models for the interpretation of environmental tracer data

    International Nuclear Information System (INIS)

    Maloszewski, P.; Zuber, A.

    1996-01-01

    Principles of the lumped-parameter approach to the interpretation of environmental tracer data are given. The following models are considered: the piston flow model (PFM), exponential flow model (EM), linear model (LM), combined piston flow and exponential flow model (EPM), combined linear flow and piston flow model (LPM), and dispersion model (DM). The applicability of these models for the interpretation of different tracer data is discussed for a steady state flow approximation. Case studies are given to exemplify the applicability of the lumped-parameter approach. Description of a user-friendly computer program is given. (author). 68 refs, 25 figs, 4 tabs

  17. Lumped-parameter Model of a Bucket Foundation

    DEFF Research Database (Denmark)

    Andersen, Lars; Ibsen, Lars Bo; Liingaard, Morten

    2009-01-01

    efficient model that can be applied in aero-elastic codes for fast evaluation of the dynamic structural response of wind turbines. The target solutions, utilised for calibration of the lumped-parameter models, are obtained by a coupled finite-element/boundaryelement scheme in the frequency domain......, and the quality of the models are tested in the time and frequency domains. It is found that precise results are achieved by lumped-parameter models with two to four internal degrees of freedom per displacement or rotation of the foundation. Further, coupling between the horizontal sliding and rocking cannot...

  18. Fundamentals of electromagnetics 1 internal behavior of lumped elements

    CERN Document Server

    Voltmer, David

    2007-01-01

    This book is the first of two volumes which have been created to provide an understanding of the basic principles and applications of electromagnetic fields for electrical engineering students. Fundamentals of Electromagnetics Vol 1: Internal Behavior of Lumped Elements focuses upon the DC and low-frequency behavior of electromagnetic fields within lumped elements. The properties of electromagnetic fields provide the basis for predicting the terminal characteristics of resistors, capacitors, and inductors. The properties of magnetic circuits are included as well. For slightly higher frequencie

  19. Lumped parameter models for the interpretation of environmental tracer data

    Energy Technology Data Exchange (ETDEWEB)

    Maloszewski, P [GSF-Inst. for Hydrology, Oberschleissheim (Germany); Zuber, A [Institute of Nuclear Physics, Cracow (Poland)

    1996-10-01

    Principles of the lumped-parameter approach to the interpretation of environmental tracer data are given. The following models are considered: the piston flow model (PFM), exponential flow model (EM), linear model (LM), combined piston flow and exponential flow model (EPM), combined linear flow and piston flow model (LPM), and dispersion model (DM). The applicability of these models for the interpretation of different tracer data is discussed for a steady state flow approximation. Case studies are given to exemplify the applicability of the lumped-parameter approach. Description of a user-friendly computer program is given. (author). 68 refs, 25 figs, 4 tabs.

  20. Error analysis of dimensionless scaling experiments with multiple points using linear regression

    International Nuclear Information System (INIS)

    Guercan, Oe.D.; Vermare, L.; Hennequin, P.; Bourdelle, C.

    2010-01-01

    A general method of error estimation in the case of multiple point dimensionless scaling experiments, using linear regression and standard error propagation, is proposed. The method reduces to the previous result of Cordey (2009 Nucl. Fusion 49 052001) in the case of a two-point scan. On the other hand, if the points follow a linear trend, it explains how the estimated error decreases as more points are added to the scan. Based on the analytical expression that is derived, it is argued that for a low number of points, adding points to the ends of the scanned range, rather than the middle, results in a smaller error estimate. (letter)

  1. Leaks, Lumps, and Lines: Stigma and Women's Bodies

    Science.gov (United States)

    Chrisler, Joan C.

    2011-01-01

    Women's bodies have often been positioned in art and popular culture as monstrous or defiled and women's bodily products (e.g., menstrual fluid, breast milk) as disgusting. This framing has led to the stigmatization of aspects of women's bodies (e.g., leaking fluids, lumps of fat, and lines in the skin that indicate aging), especially those…

  2. Primary Breast Tuberculosis Presenting as a Lump: A Rare Modern ...

    African Journals Online (AJOL)

    mammary area. A 25. year.old female, presented with a lump in the breast and infra.mammary area. She was having off and on fever without any other complaints. There was no positive family history. Primary breast tuberculosis was diagnosed on fine ...

  3. 29 CFR 4044.75 - Other lump sum benefits.

    Science.gov (United States)

    2010-07-01

    ... sum benefits. The value of a lump sum benefit which is not covered under § 4044.73 or § 4044.74 is equal to— (a) The value under the qualifying bid, if an insurer provides the benefit; or (b) The present value of the benefit as of the date of distribution, determined using reasonable actuarial assumptions...

  4. WATGIS: A GIS-Based Lumped Parameter Water Quality Model

    Science.gov (United States)

    Glenn P. Fernandez; George M. Chescheir; R. Wayne Skaggs; Devendra M. Amatya

    2002-01-01

    A Geographic Information System (GIS)­based, lumped parameter water quality model was developed to estimate the spatial and temporal nitrogen­loading patterns for lower coastal plain watersheds in eastern North Carolina. The model uses a spatially distributed delivery ratio (DR) parameter to account for nitrogen retention or loss along a drainage network. Delivery...

  5. Characterization of an air jet haptic lump display.

    Science.gov (United States)

    Bianchi, Matteo; Gwilliam, James C; Degirmenci, Alperen; Okamura, Allison M

    2011-01-01

    During manual palpation, clinicians rely on distributed tactile information to identify and localize hard lumps embedded in soft tissue. The development of tactile feedback systems to enhance palpation using robot-assisted minimally invasive surgery (RMIS) systems is challenging due to size and weight constraints, motivating a pneumatic actuation strategy. Recently, an air jet approach has been proposed for generating a lump percept. We use this technique to direct a thin stream of air through an aperture directly on the finger pad, which indents the skin in a hemispherical manner, producing a compelling lump percept. We hypothesize that the perceived parameters of the lump (e.g. size and stiffness) can be controlled by jointly adjusting air pressure and the aperture size through which air escapes. In this work, we investigate how these control variables interact to affect perceived pressure on the finger pad. First, we used a capacitive tactile sensor array to measure the effect of aperture size on output pressure, and found that peak output pressure increases with aperture size. Second, we performed a psychophysical experiment for each aperture size to determine the just noticeable difference (JND) of air pressure on the finger pad. Subject-averaged pressure JND values ranged from 19.4-24.7 kPa, with no statistical differences observed between aperture sizes. The aperture-pressure relationship and the pressure JND values will be fundamental for future display control.

  6. Intermittent reservoir daily-inflow prediction using lumped and ...

    Indian Academy of Sciences (India)

    For the present case study considered, both MLR and ARIMA models performed ... is to be remembered that the transformation of ... Multi-linear regression; lumped and distributed data; time-series models; cause-effect ... flow data are short for adequate system study. ..... that the standard deviation, skewness, kurtosis.

  7. Lump Sum Moving Cost and Aggregate Office Space Use

    NARCIS (Netherlands)

    G. Romijn

    1997-01-01

    textabstractWhen firms decide to change office space use, in many instances this involves relocation. Relocation involves sizable costs to the firm that can to a large extent be characterized as lump sum, i.e. independent of the change in demand. In this paper we propose and solve a model of the

  8. Approach to the diagnosis of a breast lump

    African Journals Online (AJOL)

    Generally, the older the woman, the greater the degree of suspicion and the more aggressive the ... When patients present with a history of a breast lump, the first crucial step is to ... A past history of a breast biopsy showing atypical hyperplasia, a family history of ... ultrasonography is the preferred modality for women under ...

  9. APPROACH TO THE DIAGNOSIS OF A BREAST LUMP

    African Journals Online (AJOL)

    breast cancer in any woman, irrespective of age.1,2 Fortunately, the vast majority of breast lumps are ... malignant breast lesions can be diagnosed in this way. When all aspects ... ultrasonography is the preferred modality for women under 35 ...

  10. Do Lumped-Parameter Models Provide the Correct Geometrical Damping?

    DEFF Research Database (Denmark)

    Andersen, Lars

    response during excitation and the geometrical damping related to free vibrations of a hexagonal footing. The optimal order of a lumped-parameter model is determined for each degree of freedom, i.e. horizontal and vertical translation as well as torsion and rocking. In particular, the necessity of coupling...... between horizontal sliding and rocking is discussed....

  11. Application of Biologically-Based Lumping To Investigate the ...

    Science.gov (United States)

    People are often exposed to complex mixtures of environmental chemicals such as gasoline, tobacco smoke, water contaminants, or food additives. However, investigators have often considered complex mixtures as one lumped entity. Valuable information can be obtained from these experiments, though this simplification provides little insight into the impact of a mixture's chemical composition on toxicologically-relevant metabolic interactions that may occur among its constituents. We developed an approach that applies chemical lumping methods to complex mixtures, in this case gasoline, based on biologically relevant parameters used in physiologically-based pharmacokinetic (PBPK) modeling. Inhalation exposures were performed with rats to evaluate performance of our PBPK model. There were 109 chemicals identified and quantified in the vapor in the chamber. The time-course kinetic profiles of 10 target chemicals were also determined from blood samples collected during and following the in vivo experiments. A general PBPK model was used to compare the experimental data to the simulated values of blood concentration for the 10 target chemicals with various numbers of lumps, iteratively increasing from 0 to 99. Large reductions in simulation error were gained by incorporating enzymatic chemical interactions, in comparison to simulating the individual chemicals separately. The error was further reduced by lumping the 99 non-target chemicals. Application of this biologic

  12. Lumped impulses, discrete displacements and a moving load analysis

    NARCIS (Netherlands)

    Kok, A.W.M.

    1997-01-01

    Finite element models are usually presented as relations between lumped forces and discrete displacements. Mostly finite element models are found by the elaboration of the method of the virtual work - which is a special case of the Galerkin's variational principle -. By application of Galerkin's

  13. Experimental realization of optical lumped nanocircuits at infrared wavelengths.

    Science.gov (United States)

    Sun, Yong; Edwards, Brian; Alù, Andrea; Engheta, Nader

    2012-01-29

    The integration of radiofrequency electronic methodologies on micro- as well as nanoscale platforms is crucial for information processing and data-storage technologies. In electronics, radiofrequency signals are controlled and manipulated by 'lumped' circuit elements, such as resistors, inductors and capacitors. In earlier work, we theoretically proposed that optical nanostructures, when properly designed and judiciously arranged, could behave as nanoscale lumped circuit elements--but at optical frequencies. Here, for the first time we experimentally demonstrate a two-dimensional optical nanocircuit at mid-infrared wavelengths. With the guidance of circuit theory, we design and fabricate arrays of Si3N4 nanorods with specific deep subwavelength cross-sections, quantitatively evaluate their equivalent impedance as lumped circuit elements in the mid-infrared regime, and by Fourier transform infrared spectroscopy show that these nanostructures can indeed function as two-dimensional optical lumped circuit elements. We further show that the connections among nanocircuit elements, in particular whether they are in series or in parallel combination, can be controlled by the polarization of impinging optical signals, realizing the notion of 'stereo-circuitry' in metatronics-metamaterials-inspired optical circuitry.

  14. Lumped thermal capacitance analysis of transient heat conduction ...

    African Journals Online (AJOL)

    Lumped thermal capacitance analysis has been undertaken to investigate the transient temperature variations, associated induced thermal stress distributions, and the structural integrity of Ghana Research Reactor-1 (GHAR R-1) vessel after 15 years of operation. The beltline configuration of the cylindrical vessel of the ...

  15. Reduction in thermal conductivity of BiSbTe lump

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, Kaleem [King Saud University, Sustainable Energy Technologies Center, College of Engineering, PO Box 800, Riyadh (Saudi Arabia); Wan, C. [Tsinghua University, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Beijing (China); Al-Eshaikh, M.A.; Kadachi, A.N. [King Saud University, Research Center, College of Engineering, PO Box 800, Riyadh (Saudi Arabia)

    2017-03-15

    In this work, systematic investigations on the thermal conductivities of BiSbTe lump, microstructured pristine BiSbTe bulk and single wall carbon nanotubes (SWCNTs)/BiSbTe bulk nanocomposites were performed. BiSbTe lumps were crushed to form a coarse powder (200 μm) and effect of particle size reduction on the effective thermal conductivity of BiSbTe (200 μm) bulk were analyzed. For further reduction in the conductivity, a two pronged strategy has been employed. First, additional refinement of BiSbTe (200 μm) were performed through ball milling in an inert environment. Second, SWCNTs in 0.75, and 1.0 vol% were distributed uniformly in the fine BiSbTe ball milled powder. The results showed that the effective thermal conductivities decrease with the reduction in the particle size from lump to BiSbTe (200 μm) bulk as well as with the addition of SWCNTs accompanied by further refinement of BiSbTe particles. The significant reduction in thermal conductivities of the lump was achieved for pure BiSbTe (200 μm) bulk and 0.75 vol% of SWCNTs/BiSbTe composite. This can be ascribed to the enhanced phonon scattering by the grain boundaries between the nanostructured BiSbTe particles as well as the interfaces between BiSbTe and the low dimensional carbon nanotubes. (orig.)

  16. Primary Breast Tuberculosis Presenting as a Lump: A Rare Modern ...

    African Journals Online (AJOL)

    A 25‑year‑old female presented with a painless lump in her right breast for 1 month duration. She gave history of low grade fever off and on for the last 2 weeks. There were no other complaints like weight loss, loss of appetite, and any cough. She was unmarried and there was no positive family history of breast tuberculosis.

  17. Multi-objective optimization and design for free piston Stirling engines based on the dimensionless power

    Science.gov (United States)

    Mou, Jian; Hong, Guotong

    2017-02-01

    In this paper, the dimensionless power is used to optimize the free piston Stirling engines (FPSE). The dimensionless power is defined as a ratio of the heat power loss and the output work. The heat power losses include the losses of expansion space, heater, regenerator, cooler and the compression space and every kind of the heat loss calculated by empirical formula. The output work is calculated by the adiabatic model. The results show that 82.66% of the losses come from the expansion space and 54.59% heat losses of expansion space come from the shuttle loss. At different pressure the optimum bore-stroke ratio, heat source temperature, phase angle and the frequency have different values, the optimum phase angles increase with the increase of pressure, but optimum frequencies drop with the increase of pressure. However, no matter what the heat source temperature, initial pressure and frequency are, the optimum ratios of piston stroke and displacer stroke all about 0.8. The three-dimensional diagram is used to analyse Stirling engine. From the three-dimensional diagram the optimum phase angle, frequency and heat source temperature can be acquired at the same time. This study offers some guides for the design and optimization of FPSEs.

  18. Comparing Jupiter and Saturn: dimensionless input rates from plasma sources within the magnetosphere

    Directory of Open Access Journals (Sweden)

    V. M. Vasyliūnas

    2008-06-01

    Full Text Available The quantitative significance for a planetary magnetosphere of plasma sources associated with a moon of the planet can be assessed only by expressing the plasma mass input rate in dimensionless form, as the ratio of the actual mass input to some reference value. Traditionally, the solar wind mass flux through an area equal to the cross-section of the magnetosphere has been used. Here I identify another reference value of mass input, independent of the solar wind and constructed from planetary parameters alone, which can be shown to represent a mass input sufficiently large to prevent corotation already at the source location. The source rate from Enceladus at Saturn has been reported to be an order of magnitude smaller (in absolute numbers than that from Io at Jupiter. Both reference values, however, are also smaller at Saturn than at Jupiter, by factors ~40 to 60; expressed in dimensionless form, the estimated mass input from Enceladus may be larger than that from Io by factors ~4 to 6. The magnetosphere of Saturn may thus, despite a lower mass input in kg s−1, intrinsically be more heavily mass-loaded than the magnetosphere of Jupiter.

  19. Dimensionless Energy Conversion Characteristics of an Air-Powered Hydraulic Vehicle

    Directory of Open Access Journals (Sweden)

    Dongkai Shen

    2018-02-01

    Full Text Available Due to the advantages of resource conservation and less exhaust emissions, compressed air-powered vehicle has attracted more and more attention. To improve the power and efficiency of air-powered vehicle, an air-powered hydraulic vehicle was proposed. As the main part of the air-powered hydraulic vehicles, HP transformer (short for Hydropneumatic transformer is used to convert the pneumatic power to higher hydraulic power. In this study, to illustrate the energy conversion characteristics of air-powered hydraulic vehicle, dimensionless mathematical model of the vehicle’s working process was set up. Through experimental study on the vehicle, the dimensionless model was verified. Through simulation study on the vehicle, the following can be obtained: firstly, the increase of the hydraulic chamber orifice and the area ratio of the pistons can lead to a higher output power, while output pressure is just the opposite. Moreover, the increase of the output pressure and the aperture of the hydraulic chamber can lead to a higher efficiency, while area ratio of the pistons played the opposite role. This research can be referred to in the performance and design optimization of the HP transformers.

  20. Comparing Jupiter and Saturn: dimensionless input rates from plasma sources within the magnetosphere

    Directory of Open Access Journals (Sweden)

    V. M. Vasyliūnas

    2008-06-01

    Full Text Available The quantitative significance for a planetary magnetosphere of plasma sources associated with a moon of the planet can be assessed only by expressing the plasma mass input rate in dimensionless form, as the ratio of the actual mass input to some reference value. Traditionally, the solar wind mass flux through an area equal to the cross-section of the magnetosphere has been used. Here I identify another reference value of mass input, independent of the solar wind and constructed from planetary parameters alone, which can be shown to represent a mass input sufficiently large to prevent corotation already at the source location. The source rate from Enceladus at Saturn has been reported to be an order of magnitude smaller (in absolute numbers than that from Io at Jupiter. Both reference values, however, are also smaller at Saturn than at Jupiter, by factors ~40 to 60; expressed in dimensionless form, the estimated mass input from Enceladus may be larger than that from Io by factors ~4 to 6. The magnetosphere of Saturn may thus, despite a lower mass input in kg s−1, intrinsically be more heavily mass-loaded than the magnetosphere of Jupiter.

  1. Representing Lumped Markov Chains by Minimal Polynomials over Field GF(q)

    Science.gov (United States)

    Zakharov, V. M.; Shalagin, S. V.; Eminov, B. F.

    2018-05-01

    A method has been proposed to represent lumped Markov chains by minimal polynomials over a finite field. The accuracy of representing lumped stochastic matrices, the law of lumped Markov chains depends linearly on the minimum degree of polynomials over field GF(q). The method allows constructing the realizations of lumped Markov chains on linear shift registers with a pre-defined “linear complexity”.

  2. An Analysis of the Effect of the U. S. Marine Corps' Lump Sum Selective Reenlistment Bonus Program on Reenlistment Decisions

    National Research Council Canada - National Science Library

    Barry, Robert

    2001-01-01

    ... the impact of personal characteristics, civilian pay, unemployment, and the lump sum bonus on reenlistment decisions, Marine retention probabilities under the lump sum payment program are compared...

  3. Unravelling abiotic and biotic controls on the seasonal water balance using data-driven dimensionless diagnostics

    Directory of Open Access Journals (Sweden)

    S. P. Seibert

    2017-06-01

    Full Text Available The baffling diversity of runoff generation processes, alongside our sketchy understanding of how physiographic characteristics control fundamental hydrological functions of water collection, storage, and release, continue to pose major research challenges in catchment hydrology. Here, we propose innovative data-driven diagnostic signatures for overcoming the prevailing status quo in catchment inter-comparison. More specifically, we present dimensionless double mass curves (dDMC which allow inference of information on runoff generation and the water balance at the seasonal and annual timescales. By separating the vegetation and winter periods, dDMC furthermore provide information on the role of biotic and abiotic controls in seasonal runoff formation. A key aspect we address in this paper is the derivation of dimensionless expressions of fluxes which ensure the comparability of the signatures in space and time. We achieve this by using the limiting factors of a hydrological process as a scaling reference. We show that different references result in different diagnostics. As such we define two kinds of dDMC which allow us to derive seasonal runoff coefficients and to characterize dimensionless streamflow release as a function of the potential renewal rate of the soil storage. We expect these signatures for storage controlled seasonal runoff formation to remain invariant, as long as the ratios of release over supply and supply over storage capacity develop similarly in different catchments. We test the proposed methods by applying them to an operational data set comprising 22 catchments (12–166 km2 from different environments in southern Germany and hydrometeorological data from 4 hydrological years. The diagnostics are used to compare the sites and to reveal the dominant controls on runoff formation. The key findings are that dDMC are meaningful signatures for catchment runoff formation at the seasonal to annual scale and that the type of

  4. Pembelajaran Seni Tari Kuda Lumping Di Desa Dukuhwaluh Kecamatan Kembaran Kab. Banyumas

    OpenAIRE

    Daryanto, Daryanto

    2011-01-01

    The goals this research were to determine: 1). What are the requirements given to prospective players of Kuda Lumping; 2). What material provided and what methods are used in training Kuda Lumping; 3). What is the cost required to conduct training of Kuda Lumping, and from which source. 4). How long does it take to produce players who are ready to perform Kuda Lumping showcased in front of an audience. From the research result shows that: 1. Requirements given to players of Kuda Lumping...

  5. PEMBELAJARAN SENI TARI KUDA LUMPING DI DESA DUKUHWALUH KECAMATAN KEMBARAN KAB. BANYUMAS

    OpenAIRE

    Daryanto Daryanto

    2011-01-01

    The goals this research were to determine: 1). What are the requirements given to prospective players of Kuda Lumping; 2). What material provided and what methods are used in training Kuda Lumping; 3). What is the cost required to conduct training of Kuda Lumping, and from which source. 4). How long does it take to produce players who are ready to perform Kuda Lumping showcased in front of an audience. From the research result shows that: 1. Requirements given to players of Kuda Lumping...

  6. Lumping procedure for a kinetic model of catalytic naphtha reforming

    Directory of Open Access Journals (Sweden)

    H. M. Arani

    2009-12-01

    Full Text Available A lumping procedure is developed for obtaining kinetic and thermodynamic parameters of catalytic naphtha reforming. All kinetic and deactivation parameters are estimated from industrial data and thermodynamic parameters are calculated from derived mathematical expressions. The proposed model contains 17 lumps that include the C6 to C8+ hydrocarbon range and 15 reaction pathways. Hougen-Watson Langmuir-Hinshelwood type reaction rate expressions are used for kinetic simulation of catalytic reactions. The kinetic parameters are benchmarked with several sets of plant data and estimated by the SQP optimization method. After calculation of deactivation and kinetic parameters, plant data are compared with model predictions and only minor deviations between experimental and calculated data are generally observed.

  7. Lumped-parameters equivalent circuit for condenser microphones modeling.

    Science.gov (United States)

    Esteves, Josué; Rufer, Libor; Ekeom, Didace; Basrour, Skandar

    2017-10-01

    This work presents a lumped parameters equivalent model of condenser microphone based on analogies between acoustic, mechanical, fluidic, and electrical domains. Parameters of the model were determined mainly through analytical relations and/or finite element method (FEM) simulations. Special attention was paid to the air gap modeling and to the use of proper boundary condition. Corresponding lumped-parameters were obtained as results of FEM simulations. Because of its simplicity, the model allows a fast simulation and is readily usable for microphone design. This work shows the validation of the equivalent circuit on three real cases of capacitive microphones, including both traditional and Micro-Electro-Mechanical Systems structures. In all cases, it has been demonstrated that the sensitivity and other related data obtained from the equivalent circuit are in very good agreement with available measurement data.

  8. Reservoir theory, groundwater transit time distributions, and lumped parameter models

    International Nuclear Information System (INIS)

    Etcheverry, D.; Perrochet, P.

    1999-01-01

    The relation between groundwater residence times and transit times is given by the reservoir theory. It allows to calculate theoretical transit time distributions in a deterministic way, analytically, or on numerical models. Two analytical solutions validates the piston flow and the exponential model for simple conceptual flow systems. A numerical solution of a hypothetical regional groundwater flow shows that lumped parameter models could be applied in some cases to large-scale, heterogeneous aquifers. (author)

  9. Role of cytological grading in the management of breast lump

    International Nuclear Information System (INIS)

    Mehmood, A.; Ahmed, M.; Jamal, S.

    2003-01-01

    Objective: To evaluate the fine needle aspiration (FNA) smears of the breast lumps using the cytological evaluation system (C1 to C5) as practiced in the National Breast Screening Programme in the UK. Results: A total of 75 patients of lump breast were included in the project. The age range was 13-75 years with a peak incidence in the 3rd decade. There were 70 (93.3%) females and 5 (6.6%) male cases. Of the total 75 cases, 7 were designated C1, 45 C2, 5 C3, 7 C4 and 11 C5. In surgical biopsies, all the 45 cases designated as C2 proved to be benign with fibroadenoma and fibrocystic change as predominant lesions. All 11 designated C5 proved to be malignant; whereas, of the 5 cases labeled as C3, 4 were benign and one was malignant and out of seven C4 cases, 5 came out as malignant and 2 proved benign. Conclusion: the fine needle aspiration of lump breast has a sensitivity of 94.1%, specificity of 96.0% and accuracy of 95.5%. The C1-C5 grading system is practical, flexible, and gives room for expression of opinion by cytopathologist and easily interpreted by clincians. (author)

  10. Lumped parametric model of the human ear for sound transmission.

    Science.gov (United States)

    Feng, Bin; Gan, Rong Z

    2004-09-01

    A lumped parametric model of the human auditoria peripherals consisting of six masses suspended with six springs and ten dashpots was proposed. This model will provide the quantitative basis for the construction of a physical model of the human middle ear. The lumped model parameters were first identified using published anatomical data, and then determined through a parameter optimization process. The transfer function of the middle ear obtained from human temporal bone experiments with laser Doppler interferometers was used for creating the target function during the optimization process. It was found that, among 14 spring and dashpot parameters, there were five parameters which had pronounced effects on the dynamic behaviors of the model. The detailed discussion on the sensitivity of those parameters was provided with appropriate applications for sound transmission in the ear. We expect that the methods for characterizing the lumped model of the human ear and the model parameters will be useful for theoretical modeling of the ear function and construction of the ear physical model.

  11. Stoichiometric network analysis and associated dimensionless kinetic equations. Application to a model of the Bray-Liebhafsky reaction.

    Science.gov (United States)

    Schmitz, Guy; Kolar-Anić, Ljiljana Z; Anić, Slobodan R; Cupić, Zeljko D

    2008-12-25

    The stoichiometric network analysis (SNA) introduced by B. L. Clarke is applied to a simplified model of the complex oscillating Bray-Liebhafsky reaction under batch conditions, which was not examined by this method earlier. This powerful method for the analysis of steady-states stability is also used to transform the classical differential equations into dimensionless equations. This transformation is easy and leads to a form of the equations combining the advantages of classical dimensionless equations with the advantages of the SNA. The used dimensionless parameters have orders of magnitude given by the experimental information about concentrations and currents. This simplifies greatly the study of the slow manifold and shows which parameters are essential for controlling its shape and consequently have an important influence on the trajectories. The effectiveness of these equations is illustrated on two examples: the study of the bifurcations points and a simple sensitivity analysis, different from the classical one, more based on the chemistry of the studied system.

  12. A Diagnosis Method for Rotation Machinery Faults Based on Dimensionless Indexes Combined with K-Nearest Neighbor Algorithm

    Directory of Open Access Journals (Sweden)

    Jianbin Xiong

    2015-01-01

    Full Text Available It is difficult to well distinguish the dimensionless indexes between normal petrochemical rotating machinery equipment and those with complex faults. When the conflict of evidence is too big, it will result in uncertainty of diagnosis. This paper presents a diagnosis method for rotation machinery fault based on dimensionless indexes combined with K-nearest neighbor (KNN algorithm. This method uses a KNN algorithm and an evidence fusion theoretical formula to process fuzzy data, incomplete data, and accurate data. This method can transfer the signals from the petrochemical rotating machinery sensors to the reliability manners using dimensionless indexes and KNN algorithm. The input information is further integrated by an evidence synthesis formula to get the final data. The type of fault will be decided based on these data. The experimental results show that the proposed method can integrate data to provide a more reliable and reasonable result, thereby reducing the decision risk.

  13. Impact of model structure on flow simulation and hydrological realism: from a lumped to a semi-distributed approach

    Science.gov (United States)

    Garavaglia, Federico; Le Lay, Matthieu; Gottardi, Fréderic; Garçon, Rémy; Gailhard, Joël; Paquet, Emmanuel; Mathevet, Thibault

    2017-08-01

    Model intercomparison experiments are widely used to investigate and improve hydrological model performance. However, a study based only on runoff simulation is not sufficient to discriminate between different model structures. Hence, there is a need to improve hydrological models for specific streamflow signatures (e.g., low and high flow) and multi-variable predictions (e.g., soil moisture, snow and groundwater). This study assesses the impact of model structure on flow simulation and hydrological realism using three versions of a hydrological model called MORDOR: the historical lumped structure and a revisited formulation available in both lumped and semi-distributed structures. In particular, the main goal of this paper is to investigate the relative impact of model equations and spatial discretization on flow simulation, snowpack representation and evapotranspiration estimation. Comparison of the models is based on an extensive dataset composed of 50 catchments located in French mountainous regions. The evaluation framework is founded on a multi-criterion split-sample strategy. All models were calibrated using an automatic optimization method based on an efficient genetic algorithm. The evaluation framework is enriched by the assessment of snow and evapotranspiration modeling against in situ and satellite data. The results showed that the new model formulations perform significantly better than the initial one in terms of the various streamflow signatures, snow and evapotranspiration predictions. The semi-distributed approach provides better calibration-validation performance for the snow cover area, snow water equivalent and runoff simulation, especially for nival catchments.

  14. A study of the consistent and the lumped source approximations in finite element neutron diffusion calculations

    International Nuclear Information System (INIS)

    Ozgener, B.; Azgener, H.A.

    1991-01-01

    In finite element formulations for the solution of the within-group neutron diffusion equation, two different treatments are possible for the group source term: the consistent source approximation (CSA) and the lumped source approximation (LSA). CSA results in intra-group scattering and fission matrices which have the same nondiagonal structure as the global coefficient matrix. This situation might be regarded as a disadvantage, compared to the conventional (i.e. finite difference) methods where the intra-group scattering and fission matrices are diagonal. To overcome this disadvantage, LSA could be used to diagonalize these matrices. LSA is akin to the lumped mass approximation of continuum mechanics. We concentrate on two different aspects of the source approximations. Although it has been reported that LSA does not modify the asymptotic h 2 convergence behaviour for linear elements, the effect of LSA on convergence of higher degree elements has not been investigated. Thus, we would be interested in determining, p, the asymptotic order of convergence, in: Δk |k eff (analytical) -k eff (finite element)| = Ch p (1) for finite element approximations of varying degree (N) with both of the source approximations. Since (1) is valid in the asymptotic limit, we must use ultra-fine meshes and quadruple precision arithmetic. For our order of convergence study, we used infinite cylindrical geometry with azimuthal symmetry. Hence, the effects of singularities remain uninvestigated. The second aspect we dwell on is the performance of LSA in bilinear 3-D finite element calculations, compared to CSA. LSA has been used quite extensively in 1- and 2-D even-parity transport and diffusion calculations. In this work, we will try to assess the relative merits of LSA and CSA in 3-D problems. (author)

  15. Incidence of malignancy in females presenting with breast lumps in OPD: a study of 277 cases

    International Nuclear Information System (INIS)

    Chaudhary, I.A.; Qureshi, S.K.; Rasul, S.

    2003-01-01

    Objective: To find the incidence of malignancy in females presenting with breast lumps in surgical out patient and to find out the age related incidence of benign and malignant diseases in these patients. Patients and Methods: All cases reporting to surgical outdoor with breast lumps were included and underwent investigation for the breast lumps to determine the histopathological diagnosis. Results: A total of 277 cases were studied. 24.2% breast lumps were malignant and 75.8% were benign. The incidence of malignancy increases from 0% in 2nd decade to 38.9% in 5th and 100% in 9th decade of life. The probability of diagnosing a breast lump as a malignant is one in three in 4th decade, two in five in 5th decade and more than one in two there after. Fibrocystic disease (33.8%) and Fibro adenoma (27.1%) was the commonest finding among the benign lumps. Among malignant lumps infiltrating duct carcinoma (68.7%) is the commonest finding. Conclusion: There is a significantly high incidence of malignant breast lumps after the 3rd decade of life and it increases subsequently. It is recommended that the surgeon managing a case of breast lump in a patient above 30 years should be highly suspicious and cautious so that early detection and management of malignant lumps be carried out. (author)

  16. Dimensionless Numerical Approaches for the Performance Prediction of Marine Waterjet Propulsion Units

    Directory of Open Access Journals (Sweden)

    Marco Altosole

    2012-01-01

    Full Text Available One of the key issues at early design stage of a high-speed craft is the selection and the performance prediction of the propulsion system because at this stage only few information about the vessel are available. The objective of this work is precisely to provide the designer, in the case of waterjet propelled craft, with a simple and reliable calculation tool, able to predict the waterjet working points in design and off-design conditions, allowing to investigate several propulsive options during the ship design process. In the paper two original dimensionless numerical procedures, one referred to jet units for naval applications and the other more suitable for planing boats, are presented. The first procedure is based on a generalized performance map for mixed flow pumps, derived from the analysis of several waterjet pumps by applying similitude principles of the hydraulic machines. The second approach, validated by some comparisons with current waterjet installations, is based on a complete physical approach, from which a set of non-dimensional waterjet characteristics has been drawn by the authors. The presented application examples show the validity and the degree of accuracy of the proposed methodologies for the performance evaluation of waterjet propulsion systems.

  17. A new dimensionless number highlighted from mechanical energy exchange during running.

    Science.gov (United States)

    Delattre, Nicolas; Moretto, Pierre

    2008-09-18

    This study aimed to highlight a new dimensionless number from mechanical energy transfer occurring at the centre of gravity (Cg) during running. We built two different-sized spring-mass models (SMM #1 and SMM #2). SMM #1 was built from the previously published data, and SMM #2 was built to be dynamically similar to SMM #1. The potential gravitational energy (E(P)), kinetic energy (E(K)), and potential elastic energy (E(E)) were taken into account to test our hypothesis. For both SMM #1 and SMM #2, N(Mo-Dela)=(E(P)+E(K))/E(E) reached the same mean value and was constant (4.1+/-0.7) between 30% and 70% of contact time. Values of N(Mo-Dela) obtained out of this time interval were due to the absence of E(E) at initial and final times of the simulation. This phenomenon does not occur during in vivo running because a leg muscle's pre-activation enables potential elastic energy storage prior to ground contact. Our findings also revealed that two different-sized spring-mass models bouncing with equal N(Mo-Dela) values moved in a dynamically similar fashion. N(Mo-Dela), which can be expressed by the combination of Strouhal and Froude numbers, could be of great interest in order to study animal and human locomotion under Earth's gravity or to induce dynamic similarity between different-sized individuals during bouncing gaits.

  18. THE DIMENSIONLESS AGE OF THE UNIVERSE: A RIDDLE FOR OUR TIME

    Energy Technology Data Exchange (ETDEWEB)

    Avelino, Arturo; Kirshner, Robert P., E-mail: aavelino@cfa.harvard.edu [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, Massachusetts, 02138 (United States)

    2016-09-01

    We present the interesting coincidence of cosmology and astrophysics that points toward a dimensionless age of the Universe H {sub 0} t {sub 0} that is close to one. Despite cosmic deceleration for 9 Gyr and acceleration since then, we find H {sub 0} t {sub 0} = 0.96 ± 0.01 for the ΛCDM model that fits SN Ia data from Pan-STARRS, CMB power spectra, and baryon acoustic oscillations. Similarly, astrophysical measures of stellar ages and the Hubble constant derived from redshifts and distances point to H {sub 0} t ∼ 1.0 ± 0.1. The wide range of possible values for H {sub 0} t {sub 0} realized during cosmic evolution means that we live at what appears to be a special time. This “synchronicity problem” is not precisely the same as the usual coincidence problem , because there are combinations of Ω{sub M} and Ω{sub Λ} for which the usual coincidence problem holds but for which H {sub 0} t {sub 0} is not close to 1.

  19. Dimensionless model to determine spontaneous combustion danger zone in the longwall gob

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xin-hai; DENG Jun; WEN Hu

    2011-01-01

    According to spontaneous combustion propensity,the longwall gob is divided into three zones,including heat dissipation zone,self-heating zone and the choking zone.Only in the self-heating zone can temperature of coal rise due to oxidation.Studying the distribution of the “Three Zones” in gob is important for predicting and preventing spontaneous combustion in coalmine.In normal mining operations,temperature of coal is roughly constant.The process of mass transfer in the gob is considered to be steady.Based on mass conservation,gas species conservation,darcy' s law,Ficks law of diffusion and coal oxidation 1-grade reaction rule,governing equation for air leakage intensity and species concentration are deduced.With critical value of coal spontaneous combustion and the size of longwall workface as basic dimension,a dimensionless steady coupled model of air flow diffusion and chemical reaction in loose coal of Fully Mechanized Top-Coal Caving Mining Workface (FMTCCMW) is setup.By solving the model numerically,regulation of three zones' distribution and spontaneous combustion in the gob can be obtained.The results can be easily popularized to prediction of spontaneous combustion in other coalmines' longwall gob.

  20. Experimental determination of the dimensionless scaling parameter of energy transport in tokamaks

    International Nuclear Information System (INIS)

    Luce, T.C.; Petty, C.C.

    1995-07-01

    Controlled fusion experiments have focused on the variation of the plasma characteristics as the engineering or control parameters are systematically changed. This has led to the development of extrapolation formulae for prediction of future device performance using these same variables as a basis. Recently, it was noticed that present-day tokamaks can operate with all of the dimensionless variables which appear in the Vlasov-Maxwell system of equations at values projected for a fusion powerplant with the exception of the parameter ρ * , the gyroradius normalized to the machine size. The scaling with this parameter is related to the benefit of increasing the size of the machine either directly or effectively by increasing the magnetic field. It is exactly this scaling which is subject to systematic error in the inter-machine databases and the cost driver for any future machine. If this scaling can be fixed by a series of single machine experiments, much as the current and power scalings have been, the confidence in the prediction of future device performance would be greatly enhanced. While carrying out experiments of this type, it was also found that the ρ * scaling can illuminate the underlying physics of energy transport. Conclusions drawn from experiments on the DIII-D tokamak in these two areas are the subject of this paper

  1. Lumped-parameter fuel rod model for rapid thermal transients

    International Nuclear Information System (INIS)

    Perkins, K.R.; Ramshaw, J.D.

    1975-07-01

    The thermal behavior of fuel rods during simulated accident conditions is extremely sensitive to the heat transfer coefficient which is, in turn, very sensitive to the cladding surface temperature and the fluid conditions. The development of a semianalytical, lumped-parameter fuel rod model which is intended to provide accurate calculations, in a minimum amount of computer time, of the thermal response of fuel rods during a simulated loss-of-coolant accident is described. The results show good agreement with calculations from a comprehensive fuel-rod code (FRAP-T) currently in use at Aerojet Nuclear Company

  2. A lumped model for rotational modes in periodic solid composites

    KAUST Repository

    Peng, Pai; Asiri, Sharefa M.; Zhang, Xiujuan; Li, Yan; Wu, Ying

    2013-01-01

    We present a lumped model to study the rotational modes in a type of two-dimensional periodic solid composites comprised of a square array of rubber-coated steel cylinders embedded in an epoxy matrix. The model captures the physical essence of rotational modes in such systems for various combinations of material parameters, and, therefore it is able to describe the transition behaviour when the system is gradually adjusted from an elastic metamaterial to an elastic phononic crystal. From the model, we can define a transition zone which separates the typical elastic metamaterials and the phononic crystals.

  3. New equivalent lumped electrical circuit for piezoelectric transformers.

    Science.gov (United States)

    Gonnard, Paul; Schmitt, P M; Brissaud, Michel

    2006-04-01

    A new equivalent circuit is proposed for a contour-vibration-mode piezoelectric transformer (PT). It is shown that the usual lumped equivalent circuit derived from the conventional Mason approach is not accurate. The proposed circuit, built on experimental measurements, makes an explicit difference between the elastic energies stored respectively on the primary and secondary parts. The experimental and theoretical resonance frequencies with the secondary in open or short circuit are in good agreement as well as the output "voltage-current" characteristic and the optimum efficiency working point. This circuit can be extended to various PT configurations and appears to be a useful tool for modeling electronic devices that integrate piezoelectric transformers.

  4. Probing lumps of wee partons in deep inelastic scattering

    International Nuclear Information System (INIS)

    Buchmueller, W.

    1994-06-01

    Recently, the ZEUS collaboration has reported on several remarkable properties of events with a large rapidity gap in deep inelastic scattering. We suggest that the mechanism underlying these events is the scattering of electrons off lumps of wee partons inside the proton. Based on an effective lagrangian approach the Q 2 -, x- and W-distributions are evaluated. For sufficiently small invariant mass of the detected hadronic system, the mechanism implies leading twist behaviour. The x- and W-distributions are determined by the Lipatov exponent which governs the behaviour of parton densities at small x. (orig.)

  5. The lumped heat capacity method applied to target heating

    OpenAIRE

    Rickards, J.

    2013-01-01

    The temperature of metal samples was measured while they were bombarded by the beam from the a particle accelerator. The evolution of the temperature with time can be explained using the lumped heat capacity method of heat transfer. A strong dependence on the type of mounting was found. Se midió la temperatura de muestras metálicas al ser bombardeadas por el haz de iones del Acelerador Pelletron del Instituto de Física. La evolución de la temperatura con el tiempo se puede explicar usando ...

  6. A lumped model for rotational modes in periodic solid composites

    KAUST Repository

    Peng, Pai

    2013-10-01

    We present a lumped model to study the rotational modes in a type of two-dimensional periodic solid composites comprised of a square array of rubber-coated steel cylinders embedded in an epoxy matrix. The model captures the physical essence of rotational modes in such systems for various combinations of material parameters, and, therefore it is able to describe the transition behaviour when the system is gradually adjusted from an elastic metamaterial to an elastic phononic crystal. From the model, we can define a transition zone which separates the typical elastic metamaterials and the phononic crystals.

  7. Development and evaluation of a dimensionless mechanistic pan coating model for the prediction of coated tablet appearance.

    Science.gov (United States)

    Niblett, Daniel; Porter, Stuart; Reynolds, Gavin; Morgan, Tomos; Greenamoyer, Jennifer; Hach, Ronald; Sido, Stephanie; Karan, Kapish; Gabbott, Ian

    2017-08-07

    A mathematical, mechanistic tablet film-coating model has been developed for pharmaceutical pan coating systems based on the mechanisms of atomisation, tablet bed movement and droplet drying with the main purpose of predicting tablet appearance quality. Two dimensionless quantities were used to characterise the product properties and operating parameters: the dimensionless Spray Flux (relating to area coverage of the spray droplets) and the Niblett Number (relating to the time available for drying of coating droplets). The Niblett Number is the ratio between the time a droplet needs to dry under given thermodynamic conditions and the time available for the droplet while on the surface of the tablet bed. The time available for drying on the tablet bed surface is critical for appearance quality. These two dimensionless quantities were used to select process parameters for a set of 22 coating experiments, performed over a wide range of multivariate process parameters. The dimensionless Regime Map created can be used to visualise the effect of interacting process parameters on overall tablet appearance quality and defects such as picking and logo bridging. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Optimum Design and Operation of Cyclic Storage Systems; Lumped Approach

    Directory of Open Access Journals (Sweden)

    Leila Ostadrahimi

    2007-01-01

    Full Text Available Conjunctive use of surface and groundwater resources is a preferred approach in water resources management. Compared to dam construction, groundwater has certain advantages, among which are less costs, less sedimentation and evaporation, fewer water quality problems, and less social and cultural problems. To reduce the major problems associated with the development of large-scale surface impoundment systems, cyclic storage systems can be used as an alternative. A cyclic storage system (CYCS is an integrated interactive system consisting of two subsystems of surface water storage (reservoir and groundwater; this system together with artificial recharge is able to satisfy the predefined demands with rather high reliability. In order to optimize these systems, one must consider the hydraulic interactions between all the components, but unfortunately it has been neglected in many studies. In this article, a nonlinear optimization model for design and operation of cyclic storage systems has been developed using the lumped approach. In order to evaluate the model, its results have been compared with the results of a model in which distributed approach had been deployed, and so the efficiency of lumped models to solve the problems of cyclic storage systems has been investigated.

  9. PHOTOSPHERE EMISSION FROM A HYBRID RELATIVISTIC OUTFLOW WITH ARBITRARY DIMENSIONLESS ENTROPY AND MAGNETIZATION IN GRBs

    Energy Technology Data Exchange (ETDEWEB)

    Gao, He [Current address: Department of Astronomy and Astrophysics, Department of Physics, Center for Particle Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Zhang, Bing, E-mail: gaohe@physics.unlv.edu, E-mail: zhang@physics.unlv.edu, E-mail: hug18@psu.edu [Department of Physics and Astronomy, University of Nevada, Las Vegas, NV 89154 (United States)

    2015-03-10

    In view of the recent Fermi observations of gamma-ray burst (GRB) prompt emission spectra, we develop a theory of photosphere emission of a hybrid relativistic outflow with a hot fireball component (defined by dimensionless entropy η) and a cold Poynting-flux component (defined by magnetization σ{sub 0} at the central engine). We consider the scenarios both without and with sub-photospheric magnetic dissipations. Based on a simplified toy model of jet dynamics, we develop two approaches: a 'bottom-up' approach to predict the temperature (for a non-dissipative photosphere) and luminosity of the photosphere emission and its relative brightness for a given pair of (η, σ{sub 0}); and a 'top-down' approach to diagnose central engine parameters (η and σ{sub 0}) based on the observed quasi-thermal photosphere emission properties. We show that a variety of observed GRB prompt emission spectra with different degrees of photosphere thermal emission can be reproduced by varying η and σ{sub 0} within the non-dissipative photosphere scenario. In order to reproduce the observed spectra, the outflows of most GRBs need to have a significant σ, both at the central engine and at the photosphere. The σ value at 10{sup 15} cm from the central engine (a possible non-thermal emission site) is usually also greater than unity, so that internal-collision-induced magnetic reconnection and turbulence (ICMART) may be the mechanism to power the non-thermal emission. We apply our top-down approach to GRB 110721A and find that the temporal evolution behavior of its blackbody component can be well interpreted with a time-varying (η, σ{sub 0}) at the central engine, instead of invoking a varying engine base size r {sub 0} as proposed by previous authors.

  10. Metastatic uterine leiomyosarcoma presenting as a breast lump.

    LENUS (Irish Health Repository)

    Sibartie, S

    2009-01-31

    BACKGROUND: It is uncommon to encounter a breast metastasis from an extramammary malignancy and even rarer from a uterine leiomyosarcoma. AIMS: We describe the third case report in the medical literature of a breast metastasis from a uterine leiomyosarcoma. METHODS: We report the management of a 56-year-old patient who presented with a breast lump 3 years after hysterectomy for a fibroid uterus. We conducted a literature review of breast leiomyosarcomas. RESULTS: The excision of the breast mass revealed a low-grade leiomyosarcoma. Radiographic examinations demonstrated metastases to the lung, liver, pelvis and bone. Retrospective pathology review of her uterus identified a small focus of leiomyosarcoma. She received chemotherapy and palliative radiotherapy but passed away within few months. CONCLUSION: Metastasis to the breast from a non-breast primary is generally a sign of disseminated disease and; thus, a poor prognostic indicator.

  11. Lumped model for rotational modes in phononic crystals

    KAUST Repository

    Peng, Pai

    2012-10-16

    We present a lumped model for the rotational modes induced by the rotational motion of individual scatterers in two-dimensional phononic crystals comprised of square arrays of solid cylindrical scatterers in solid hosts. The model provides a physical interpretation of the origin of the rotational modes, reveals the important role played by the rotational motion in determining the band structure, and reproduces the dispersion relations in a certain range. The model increases the possibilities of manipulating wave propagation in phononic crystals. In particular, expressions derived from the model for eigenfrequencies at high symmetry points unambiguously predict the presence of a new type of Dirac-like cone at the Brillouin center, which is found to be the result of accidental degeneracy of the rotational and dipolar modes.

  12. Lumped model for rotational modes in phononic crystals

    KAUST Repository

    Peng, Pai; Mei, Jun; Wu, Ying

    2012-01-01

    We present a lumped model for the rotational modes induced by the rotational motion of individual scatterers in two-dimensional phononic crystals comprised of square arrays of solid cylindrical scatterers in solid hosts. The model provides a physical interpretation of the origin of the rotational modes, reveals the important role played by the rotational motion in determining the band structure, and reproduces the dispersion relations in a certain range. The model increases the possibilities of manipulating wave propagation in phononic crystals. In particular, expressions derived from the model for eigenfrequencies at high symmetry points unambiguously predict the presence of a new type of Dirac-like cone at the Brillouin center, which is found to be the result of accidental degeneracy of the rotational and dipolar modes.

  13. A lumped parameter, low dimension model of heat exchanger

    International Nuclear Information System (INIS)

    Kanoh, Hideaki; Furushoo, Junji; Masubuchi, Masami

    1980-01-01

    This paper reports on the results of investigation of the distributed parameter model, the difference model, and the model of the method of weighted residuals for heat exchangers. By the method of weighted residuals (MWR), the opposite flow heat exchanger system is approximated by low dimension, lumped parameter model. By assuming constant specific heat, constant density, the same form of tube cross-section, the same form of the surface of heat exchange, uniform flow velocity, the linear relation of heat transfer to flow velocity, liquid heat carrier, and the thermal insulation of liquid from outside, fundamental equations are obtained. The experimental apparatus was made of acrylic resin. The response of the temperature at the exit of first liquid to the variation of the flow rate of second liquid was measured and compared with the models. The MWR model shows good approximation for the low frequency region, and as the number of division increases, good approximation spreads to higher frequency region. (Kato, T.)

  14. 24 CFR 570.513 - Lump sum drawdown for financing of property rehabilitation activities.

    Science.gov (United States)

    2010-04-01

    ... DEVELOPMENT BLOCK GRANTS Grant Administration § 570.513 Lump sum drawdown for financing of property... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Lump sum drawdown for financing of property rehabilitation activities. 570.513 Section 570.513 Housing and Urban Development Regulations...

  15. 20 CFR 222.44 - Other relationship determinations for lump-sum payments.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Other relationship determinations for lump... THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Parent, Grandchild, Brother or Sister... have the relationships to the employee shown below for lump-sum payment purposes: (a) Grandchildren. A...

  16. 29 CFR Appendix A to Part 4022 - Lump Sum Mortality Rates

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Lump Sum Mortality Rates A Appendix A to Part 4022 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION COVERAGE AND BENEFITS BENEFITS PAYABLE IN TERMINATED SINGLE-EMPLOYER PLANS Pt. 4022, App. A Appendix A to Part 4022—Lump Sum Mortality...

  17. 29 CFR Appendix C to Part 4022 - Lump Sum Interest Rates for Private-Sector Payments

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Lump Sum Interest Rates for Private-Sector Payments C Appendix C to Part 4022 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY... Appendix C to Part 4022—Lump Sum Interest Rates for Private-Sector Payments [In using this table: (1) For...

  18. A correction technique for the dispersive effects of mass lumping for transport problems

    KAUST Repository

    Guermond, Jean-Luc; Pasquetti, Richard

    2013-01-01

    This paper addresses the well-known dispersion effect that mass lumping induces when solving transport-like equations. A simple anti-dispersion technique based on the lumped mass matrix is proposed. The method does not require any non-trivial matrix

  19. Hovering efficiency comparison of rotary and flapping flight for a rigid and rectangular wings via dimensionless multi-objective optimization.

    Science.gov (United States)

    Bayiz, Yagiz Efe; Ghanaatpishe, Mohammad; Fathy, Hosam; Cheng, Bo

    2018-03-20

    In this work, a multi-objective optimization framework is developed for optimizing low-Reynolds number (Re) hovering flight. This framework is then applied to compare the efficiency of rigid revolving and flapping wings with rectangular shape under varying Re and Rossby number (Ro, or aspect ratio). The proposed framework is capable of generating sets of optimal solutions and Pareto fronts for maximizing lift coefficient and minimizing power coefficient in dimensionless space, which explicitly reveal the trade off between lift generation and power consumption. The results indicate that revolving wings are more efficient if the required average lift coefficient CL is low (< 1 for Re = 100 and < 1.6 for Re = 8000), while flapping wings are more efficient in achieving higher CL. Using dimensionless power loading as the single objective performance measure to be maximized, rotary flight is more efficient than flapping wings for Re > 100 regardless of the amount of energy storage assumed in the flapping-wing actuation mechanism, while flapping flight becomes more efficient for Re < 100. It is observed that wings with low Ro perform better if higher CL is needed, whereas higher Ro cases are more efficient at CL < 0.9 region. However, for the selected geometry and Re, the efficiency is weakly dependent on Ro if the dimensionless power loading is maximized. © 2018 IOP Publishing Ltd.

  20. A Temperature Dependent Lumped-charge Model for Trench FS-IGBT

    DEFF Research Database (Denmark)

    Duan, Yaoqiang; Kang, Yong; Iannuzzo, Francesco

    2018-01-01

    Abstract: This paper proposes a temperature dependent lumped-charge model for FS-IGBT. Due to the evolution of the IGBT structure, the existing lumped-charge IGBT model established for NPT-IGBT is not suitable for the simulation of FS-IGBT. This paper extends the lumped-charge IGBT model including...... the field-stop (FS) structure and temperature characteristics. The temperature characteristics of the model are considered for both the bipolar part and unipolar part. In addition, a new PN junction model which can distinguish the collector structure is presented and validated by TCAD simulation. Finally...

  1. PEMBELAJARAN SENI TARI KUDA LUMPING DI DESA DUKUHWALUH KECAMATAN KEMBARAN KAB. BANYUMAS

    Directory of Open Access Journals (Sweden)

    Daryanto Daryanto

    2011-03-01

    Full Text Available The goals this research were to determine: 1. What are the requirements given to prospective players of Kuda Lumping; 2. What material provided and what methods are used in training Kuda Lumping; 3. What is the cost required to conduct training of Kuda Lumping, and from which source. 4. How long does it take to produce players who are ready to perform Kuda Lumping showcased in front of an audience. From the research result shows that: 1. Requirements given to players of Kuda Lumping (Ebeg, are namely: (1 has Kuda Lumping, (2 can dance in group / compact dance, (3 perform the ritual bathing and diving in rivers and (4 conduct ”Ngasrep” or fasting for 3 (three days without stopping. 2. The practice material was first given to prospective players Kuda Lumping is dance. In practing the dance material, the new dancers were directly guided by the seniors. The method used is by giving examples of dancing by the senior players to prospective players. When giving examples accompanied by gamelan / music, while dancer candidates of Kuda Lumping followed. 3. Fee required for training activities at least IDR 400,000,- (four hundred thousand rupiah. This cost does not include the cost to buy a kuda lumping. Sources of cost comes from the self-help group members of kuda lumping, like dalang ( director of the dance and local people. It means the training and activities of Kuda Lumping, did not receive funding / donations from the government, both the village and district governments. The cost for training activities was used to rent the gamelan, to purchase clothing / costume players, “sesaji”, consumption and honorariums. 4. To train / produce, it take a player at least 3.5 (three and a half months and a maximum of 7 (seven months. This calculation is based on the starting time of dance exercise, until doing the bath in the river as the last stage. Key Wordsi: Kuda lumping, learning ,ngasrep, ritual of bathe, ritual offerings, wayang,

  2. A correction technique for the dispersive effects of mass lumping for transport problems

    KAUST Repository

    Guermond, Jean-Luc

    2013-01-01

    This paper addresses the well-known dispersion effect that mass lumping induces when solving transport-like equations. A simple anti-dispersion technique based on the lumped mass matrix is proposed. The method does not require any non-trivial matrix inversion and has the same anti-dispersive effects as the consistent mass matrix. A novel quasi-lumping technique for P2 finite elements is introduced. Higher-order extensions of the method are also discussed. © 2012 Elsevier B.V.

  3. Lump solutions with interaction phenomena in the (2+1)-dimensional Ito equation

    Science.gov (United States)

    Zou, Li; Yu, Zong-Bing; Tian, Shou-Fu; Feng, Lian-Li; Li, Jin

    2018-03-01

    In this paper, we consider the (2+1)-dimensional Ito equation, which was introduced by Ito. By considering the Hirota’s bilinear method, and using the positive quadratic function, we obtain some lump solutions of the Ito equation. In order to ensure rational localization and analyticity of these lump solutions, some sufficient and necessary conditions are provided on the parameters that appeared in the solutions. Furthermore, the interaction solutions between lump solutions and the stripe solitons are discussed by combining positive quadratic function with exponential function. Finally, the dynamic properties of these solutions are shown via the way of graphical analysis by selecting appropriate values of the parameters.

  4. Preparation of lumped fission product (FP) cross sections for a multigroup library

    International Nuclear Information System (INIS)

    Ono, S.; Corcuera, R.P.

    1984-01-01

    A method for the calculation of lumped Fission Product (FP) cross sections has been developed. The group constants fo each nuclide are generated by NJOY code, based on ENDF/B-V data. In this first version, cross section of 28 nuclides are lumped for typical characteristics of Binary Breeder Reactor (BBR). One energy group calculations are made for a 1000 MWe fast reactor to verify the influence of burnup, number of FP and fuel composition on the lumped fission product cross sections. (Author) [pt

  5. Depletion optimization of lumped burnable poisons in pressurized water reactors

    International Nuclear Information System (INIS)

    Kodah, Z.H.

    1982-01-01

    Techniques were developed to construct a set of basic poison depletion curves which deplete in a monotonical manner. These curves were combined to match a required optimized depletion profile by utilizing either linear or non-linear programming methods. Three computer codes, LEOPARD, XSDRN, and EXTERMINATOR-2 were used in the analyses. A depletion routine was developed and incorporated into the XSDRN code to allow the depletion of fuel, fission products, and burnable poisons. The Three Mile Island Unit-1 reactor core was used in this work as a typical PWR core. Two fundamental burnable poison rod designs were studied. They are a solid cylindrical poison rod and an annular cylindrical poison rod with water filling the central region.These two designs have either a uniform mixture of burnable poisons or lumped spheroids of burnable poisons in the poison region. Boron and gadolinium are the two burnable poisons which were investigated in this project. Thermal self-shielding factor calculations for solid and annular poison rods were conducted. Also expressions for overall thermal self-shielding factors for one or more than one size group of poison spheroids inside solid and annular poison rods were derived and studied. Poison spheroids deplete at a slower rate than the poison mixture because each spheroid exhibits some self-shielding effects of its own. The larger the spheroid, the higher the self-shielding effects due to the increase in poison concentration

  6. Removal in a lump of JRR-3 nuclear reactor

    International Nuclear Information System (INIS)

    Ohnishi, Nobuaki; Suzuki, Masanori; Nagase, Tetsuo; Watanabe, Morinari.

    1989-01-01

    The research reactor JRR-3 in Japan Atomic Energy Research Institute is called 'Home made No.1 reactor' as all except fuel and heavy water as the moderator and coolant were manufactured in Japan. The JRR-3 attained the criticality in 1962, and the cumulative time of operation reached 47135.5 hours, and the cumulative power output reached 419073.5 MWh. It was stopped in 1983. During the period, it was utilized for beam experiment, irradiation of fuel and materials, RI production and others. In order to cope with the expansion of utilization and the advance of utilizing technology of the research reactor, the reconstruction works are in progress, and the criticality of the reconstructed reactor is expected in 1990. On the site where the old reactor is removed, the reactor of different type is installed, and the first large cold neutron source is equipped. In this report, as to the removal of the old reactor proper, the method of working and the results are described. Considering the period of working, the cost and the management of the removed reactor, in the case of the JRR-3, the method of carrying it out in a lump was adopted as the optimum removal method. The plan, procedure and results of the removal working are reported. (K.I.)

  7. Finding and testing network communities by lumped Markov chains.

    Science.gov (United States)

    Piccardi, Carlo

    2011-01-01

    Identifying communities (or clusters), namely groups of nodes with comparatively strong internal connectivity, is a fundamental task for deeply understanding the structure and function of a network. Yet, there is a lack of formal criteria for defining communities and for testing their significance. We propose a sharp definition that is based on a quality threshold. By means of a lumped Markov chain model of a random walker, a quality measure called "persistence probability" is associated to a cluster, which is then defined as an "α-community" if such a probability is not smaller than α. Consistently, a partition composed of α-communities is an "α-partition." These definitions turn out to be very effective for finding and testing communities. If a set of candidate partitions is available, setting the desired α-level allows one to immediately select the α-partition with the finest decomposition. Simultaneously, the persistence probabilities quantify the quality of each single community. Given its ability in individually assessing each single cluster, this approach can also disclose single well-defined communities even in networks that overall do not possess a definite clusterized structure.

  8. Finding and testing network communities by lumped Markov chains.

    Directory of Open Access Journals (Sweden)

    Carlo Piccardi

    Full Text Available Identifying communities (or clusters, namely groups of nodes with comparatively strong internal connectivity, is a fundamental task for deeply understanding the structure and function of a network. Yet, there is a lack of formal criteria for defining communities and for testing their significance. We propose a sharp definition that is based on a quality threshold. By means of a lumped Markov chain model of a random walker, a quality measure called "persistence probability" is associated to a cluster, which is then defined as an "α-community" if such a probability is not smaller than α. Consistently, a partition composed of α-communities is an "α-partition." These definitions turn out to be very effective for finding and testing communities. If a set of candidate partitions is available, setting the desired α-level allows one to immediately select the α-partition with the finest decomposition. Simultaneously, the persistence probabilities quantify the quality of each single community. Given its ability in individually assessing each single cluster, this approach can also disclose single well-defined communities even in networks that overall do not possess a definite clusterized structure.

  9. Towards a lumped reaction model for future designer fuels

    Energy Technology Data Exchange (ETDEWEB)

    Vandersickel, A.; Wright, Y.M.; Boulouchos, K. [ETH Zurich, Aerothermochemistry and Combustion Systems Laboratory, Zurich (Switzerland). Inst. of Energy Technology

    2009-07-01

    The homogeneous charge compression ignition (HCCI) is one of the most promising engine processes to simultaneously reduce nitrogen oxide and soot emissions. However, its applicability is hindered by its relatively limited operating range. Designer fuels offer unique possibilities for tailoring evaporation and auto-ignition properties, offering a means to control and expand the HCCI operation range. The identification of HCCI relevant fuel properties as well as the definition of a new fuel index able to describe a fuels suitability for HCCI was required in order to develop such designer fuels. This paper discussed a numerical and experimental investigation of a large set of technical fuels covering a wide range of properties. The paper discussed mechanism development approaches, optimization of the lumped mechanism, and and results. Zheng's 7-step reaction mechanism was successfully coupled with a genetic optimization algorithm and fitted to n-heptane ignition delay data. It was concluded that the presented coupled approach could improve the predictive quality of the model and demonstrate that the Zheng model was sufficiently elaborate to emulate the influence of temperature, pressure, exhaust gas recirculation and lambda on ignition. 8 refs., 1 tab., 3 figs.

  10. Towards a lumped reaction model for future designer fuels

    International Nuclear Information System (INIS)

    Vandersickel, A.; Wright, Y.M.; Boulouchos, K.

    2009-01-01

    The homogeneous charge compression ignition (HCCI) is one of the most promising engine processes to simultaneously reduce nitrogen oxide and soot emissions. However, its applicability is hindered by its relatively limited operating range. Designer fuels offer unique possibilities for tailoring evaporation and auto-ignition properties, offering a means to control and expand the HCCI operation range. The identification of HCCI relevant fuel properties as well as the definition of a new fuel index able to describe a fuels suitability for HCCI was required in order to develop such designer fuels. This paper discussed a numerical and experimental investigation of a large set of technical fuels covering a wide range of properties. The paper discussed mechanism development approaches, optimization of the lumped mechanism, and and results. Zheng's 7-step reaction mechanism was successfully coupled with a genetic optimization algorithm and fitted to n-heptane ignition delay data. It was concluded that the presented coupled approach could improve the predictive quality of the model and demonstrate that the Zheng model was sufficiently elaborate to emulate the influence of temperature, pressure, exhaust gas recirculation and lambda on ignition. 8 refs., 1 tab., 3 figs.

  11. Dimensionless scalings of confinement, heat transport and pedestal stability in JET-ILW and comparison with JET-C

    Czech Academy of Sciences Publication Activity Database

    Frassinetti, L.; Saarelma, S.; Lomas, P.; Nunes, I.; Rimini, F.; Beurskens, M.N.A.; Bílková, Petra; Boom, J.E.; De La Luna, E.; Delabie, E.; Drewelow, P.; Flanagan, J.; Garzotti, L.; Giroud, C.; Hawks, N.; Joffrin, E.; Kempenaars, M.; Kim, H.-T.; Kruezi, U.; Loarte, A.; Lomanowski, B.; Lupelli, I.; Meneses, L.; Maggi, C.F.; Menmuir, S.; Peterka, Matěj; Rachlew, E.; Romanelli, M.; Stefanikova, E.

    2017-01-01

    Roč. 59, č. 1 (2017), č. článku 014014. ISSN 0741-3335. [EPS 2016: Conference on Plasma Physics/43./. Leuven, 04.07.2016-08.07.2016] EU Projects: European Commission(XE) 633053 - EUROfusion Institutional support: RVO:61389021 Keywords : JET-ILW * dimensionless scaling * pedestal * confinement * pedestal stability * heat transport Subject RIV: BL - Plasma and Gas Discharge Physics OBOR OECD: Fluids and plasma physics (including surface physics) Impact factor: 2.392, year: 2016 http://dx.doi.org/10.1088/0741-3335/59/1/014014

  12. Application of Biologically-Based Lumping To Investigate the Toxicological Interactions of a Complex Gasoline Mixture

    Science.gov (United States)

    People are often exposed to complex mixtures of environmental chemicals such as gasoline, tobacco smoke, water contaminants, or food additives. However, investigators have often considered complex mixtures as one lumped entity. Valuable information can be obtained from these exp...

  13. Modelling of nonhomogeneous atmosphere in NPP containment using lumped-parameter model based on CFD calculations

    International Nuclear Information System (INIS)

    Ivo, Kljenak; Miroslav, Babic; Borut, Mavko

    2007-01-01

    The possibility of simulating adequately the flow circulation within a nuclear power plant containment using a lumped-parameter code is considered. An experiment on atmosphere mixing and stratification, which was performed in the containment experimental facility TOSQAN at IRSN (Institute of Radioprotection and Nuclear Safety) in Saclay (France), was simulated with the CFD (Computational Fluid Dynamics) code CFX4 and the lumped-parameter code CONTAIN. During some phases of the experiment, steady states were achieved by keeping the boundary conditions constant. Two steady states during which natural convection was the dominant gas flow mechanism were simulated independently. The nodalization of the lumped-parameter model was based on the flow pattern, simulated with the CFD code. The simulation with the lumped-parameter code predicted basically the same flow circulation patterns within the experimental vessel as the simulation with the CFD code did. (authors)

  14. Some error estimates for the lumped mass finite element method for a parabolic problem

    KAUST Repository

    Chatzipantelidis, P.; Lazarov, R. D.; Thomé e, V.

    2012-01-01

    for the standard Galerkin method carry over to the lumped mass method whereas nonsmooth initial data estimates require special assumptions on the triangulation. We also discuss the application to time discretization by the backward Euler and Crank-Nicolson methods

  15. Uncovering and testing the fuzzy clusters based on lumped Markov chain in complex network.

    Science.gov (United States)

    Jing, Fan; Jianbin, Xie; Jinlong, Wang; Jinshuai, Qu

    2013-01-01

    Identifying clusters, namely groups of nodes with comparatively strong internal connectivity, is a fundamental task for deeply understanding the structure and function of a network. By means of a lumped Markov chain model of a random walker, we propose two novel ways of inferring the lumped markov transition matrix. Furthermore, some useful results are proposed based on the analysis of the properties of the lumped Markov process. To find the best partition of complex networks, a novel framework including two algorithms for network partition based on the optimal lumped Markovian dynamics is derived to solve this problem. The algorithms are constructed to minimize the objective function under this framework. It is demonstrated by the simulation experiments that our algorithms can efficiently determine the probabilities with which a node belongs to different clusters during the learning process and naturally supports the fuzzy partition. Moreover, they are successfully applied to real-world network, including the social interactions between members of a karate club.

  16. New Procedure to Develop Lumped Kinetic Models for Heavy Fuel Oil Combustion

    KAUST Repository

    Han, Yunqing; Elbaz, Ayman M.; Roberts, William L.; Im, Hong G.

    2016-01-01

    A new procedure to develop accurate lumped kinetic models for complex fuels is proposed, and applied to the experimental data of the heavy fuel oil measured by thermogravimetry. The new procedure is based on the pseudocomponents representing

  17. The frequency of malignancy in breast lumps on fnac in females under 35 years of age

    International Nuclear Information System (INIS)

    Iqbal, M.; Iqbal, M.

    2014-01-01

    Breast carcinoma is one of the common malignancies in females and its incidence is increasing in younger age. Diagnosis of carcinoma breast includes clinical evaluation, imaging and pathology. Fine Needle Aspiration Cytology is the first line pathological investigation in the diagnosis with excellent results. Objective: To determine the frequency of malignancy in breast lumps on FNAC in females under 35 years of age. Descriptive cross sectional study. Setting:Department of pathology Fatima Jinnah Medical College (FJMC), Lahore. Duration: Six months from 20th July, 2011 till 20th January, 2012.Methods: 150 female patients 35 years of age or less, presenting to the OPD and Indoor of Sir Ganga Ram Hospital Lahore, an affiliated hospital of FJMC Lahore, with breast lumps were included in the study. Demographic features and consent of the patients were noted. FNAC of the patients was performed as per advice of the consultant. Diagnosis of malignant cases was further confirmed on histology.Results: Out of all, 124 lumps (82.7%) were benign and 26 lumps (17.3%) were malignant. Amongst the benign lumps, 77(62.1%) were fibroadenomas, 28(22.6%) were fibrocystic changes, 08(06.5%) were inflammatory lesions, 07(05.6%) showed pyogenic abscess and 04 lumps (03.2%) were galactoceles. Amongst the malignant lumps, 22(84.6%) were ductal carcinoma, 02(07.7%) colloid carcinoma and 02(07.7%) were malignant phylloides. Conclusions: The frequency of malignancy in breast lumps in Pakistan is significantly high in females under 35 years of age. Appropriate measures are needed for prevention and early diagnosis and treatment in young females. (author)

  18. Using a lumped conceptual hydrological model for five different catchments in Sweden

    OpenAIRE

    Ekenberg, Madeleine

    2016-01-01

    Hydrological models offer powerful tools for understanding and predicting. In this thesis we havereviewed the advantages and disadvantages of physically based distributed hydrological models andconceptually lumped hydrological models. Based on that review, we went into depth and developed aMATLAB code to test if a simple conceptual lumped hydrological model, namely GR2M, wouldperform satisfactory for five different catchments in different parts of Sweden. The model had ratherunsatisfactory re...

  19. Some error estimates for the lumped mass finite element method for a parabolic problem

    KAUST Repository

    Chatzipantelidis, P.

    2012-01-01

    We study the spatially semidiscrete lumped mass method for the model homogeneous heat equation with homogeneous Dirichlet boundary conditions. Improving earlier results we show that known optimal order smooth initial data error estimates for the standard Galerkin method carry over to the lumped mass method whereas nonsmooth initial data estimates require special assumptions on the triangulation. We also discuss the application to time discretization by the backward Euler and Crank-Nicolson methods. © 2011 American Mathematical Society.

  20. Cross sections of the lumped fission products for the AMZ library

    International Nuclear Information System (INIS)

    Ono, S.; Corcueca, R.P.; Nascimento, J.A.

    1985-01-01

    The preparation of the lumped fission product cross section for the AMZ library is described. For this purpose 100 nuclides were selected. The cross sections for each nuclide were generated by the NJOY code with evaluated nuclear data from ENDF/B-V, complemented with ENDF/B-IV data. A comparison is performed between the data obtained and the lumped fission product cross section of JFS-II [pt

  1. Flexibility, stroke, and dimensionless parameters: the importance of telling the whole story for swimming micro-organisms in complex fluids

    Science.gov (United States)

    Thomases, Becca; Guy, Robert

    2015-11-01

    The question of how fluid elasticity affects the swimming performance of micro-organisms is complicated and has been the subject of many recent experimental and theoretical studies. The Deborah number, De = λω , is typically used to characterize the strength of the fluid elasticity in these studies, and for swimmers is expressed as the product of the elastic relaxation time and the frequency of the swimmer stroke. In simulations of undulatory flexible swimmers in an Oldroyd-B-type fluid, we find that varying the frequency of the stroke and varying the relaxation time separately results in a significantly different dependence of swimming speed for the same De . Thus the elastic effects on swimming cannot be characterized by a single dimensionless number. The Weissenberg number, defined as the product of elastic relaxation time and characteristic strain rate (Wi = λγ˙), is another dimensionless parameter useful for describing complex fluids. For a fixed swimmer frequency, varying the relaxation time will also vary the Weissenberg number. We conjecture that the different behavior is a consequence of a Weissenberg-number transition in the fluid, which additionally depends on the amplitude of the swimmer stroke.

  2. Technical characterization of dialysis fluid flow and mass transfer rate in dialyzers with various filtration coefficients using dimensionless correlation equation.

    Science.gov (United States)

    Fukuda, Makoto; Yoshimura, Kengo; Namekawa, Koki; Sakai, Kiyotaka

    2017-06-01

    The objective of the present study is to evaluate the effect of filtration coefficient and internal filtration on dialysis fluid flow and mass transfer coefficient in dialyzers using dimensionless mass transfer correlation equations. Aqueous solution of vitamin B 12 clearances were obtained for REXEED-15L as a low flux dialyzer, and APS-15EA and APS-15UA as high flux dialyzers. All the other design specifications were identical for these dialyzers except for filtration coefficient. The overall mass transfer coefficient was calculated, moreover, the exponents of Reynolds number (Re) and film mass transfer coefficient of the dialysis-side fluid (k D ) for each flow rate were derived from the Wilson plot and dimensionless correlation equation. The exponents of Re were 0.4 for the low flux dialyzer whereas 0.5 for the high flux dialyzers. Dialysis fluid of the low flux dialyzer was close to laminar flow because of its low filtration coefficient. On the other hand, dialysis fluid of the high flux dialyzers was assumed to be orthogonal flow. Higher filtration coefficient was associated with higher k D influenced by mass transfer rate through diffusion and internal filtration. Higher filtration coefficient of dialyzers and internal filtration affect orthogonal flow of dialysis fluid.

  3. The H-mode pedestal, ELMs and TF ripple effects in JT-60U/JET dimensionless identity experiments

    International Nuclear Information System (INIS)

    Saibene, G.; Oyama, N.; Loennroth, J.; Andrew, Y.; Luna, E. de la; Giroud, C.; Huysmans, G.T.A.; Kamada, Y.; Kempenaars, M.A.H.; Loarte, A.; Donald, D. Mc; Nave, M.M.F.; Meiggs, A.; Parail, V.; Sartori, R.; Sharapov, S.; Stober, J.; Suzuki, T.; Takechi, M.; Toi, K.; Urano, H.

    2007-01-01

    This paper summarizes results of dimensionless identity experiments in JT-60U and JET, aimed at the comparison of the H-mode pedestal and ELM behaviour in the two devices. Given their similar size, dimensionless matched plasmas are also similar in their dimensional parameters (in particular, the plasma minor radius a is the same in JET and JT-60U). Power and density scans were carried out at two values of I p , providing a q scan (q 95 = 3.1 and 5.1) with fixed (and matched) toroidal field. Contrary to initial expectations, a dimensionless match between the two devices was quite difficult to achieve. In general, p ped in JT-60U is lower than in JET and, at low q, the pedestal pressure of JT-60U with a Type I ELMy edge is matched in JET only in the Type III ELM regime. At q 95 = 5.1, a dimensionless match in ρ*, ν* and β p,ped is obtained with Type I ELMs, but only with low power JET H-modes. These results motivated a closer investigation of experimental conditions in the two devices, to identify possible 'hidden' physics that prevents obtaining a good match of pedestal values over a large range of plasmas parameters. Ripple-induced ion losses of the medium bore plasma used in JT-60U for the similarity experiments are identified as the main difference with JET. The magnitude of the JT-60U ripple losses is sufficient to induce counter-toroidal rotation in co-injected plasma. The influence of ripple losses was demonstrated at q 95 = 5.1: reducing ripple losses by ∼2 (from 4.3 to 1.9 MW) by replacing positive with negative neutral beam injection at approximately constant P in resulted in an increased p ped in JT-60U, providing a good match to full power JET H-modes. At the same time, the counter-toroidal rotation decreased. Physics mechanisms relating ripple losses to pedestal performance are not yet identified, and the possible role of velocity shear in the pedestal stability, as well as the possible influence of ripple on thermal ion transport are briefly

  4. Application of Biologically Based Lumping To Investigate the Toxicokinetic Interactions of a Complex Gasoline Mixture.

    Science.gov (United States)

    Jasper, Micah N; Martin, Sheppard A; Oshiro, Wendy M; Ford, Jermaine; Bushnell, Philip J; El-Masri, Hisham

    2016-03-15

    People are often exposed to complex mixtures of environmental chemicals such as gasoline, tobacco smoke, water contaminants, or food additives. We developed an approach that applies chemical lumping methods to complex mixtures, in this case gasoline, based on biologically relevant parameters used in physiologically based pharmacokinetic (PBPK) modeling. Inhalation exposures were performed with rats to evaluate the performance of our PBPK model and chemical lumping method. There were 109 chemicals identified and quantified in the vapor in the chamber. The time-course toxicokinetic profiles of 10 target chemicals were also determined from blood samples collected during and following the in vivo experiments. A general PBPK model was used to compare the experimental data to the simulated values of blood concentration for 10 target chemicals with various numbers of lumps, iteratively increasing from 0 to 99. Large reductions in simulation error were gained by incorporating enzymatic chemical interactions, in comparison to simulating the individual chemicals separately. The error was further reduced by lumping the 99 nontarget chemicals. The same biologically based lumping approach can be used to simplify any complex mixture with tens, hundreds, or thousands of constituents.

  5. Axillary silicone lymphadenopathy presenting with a lump and altered sensation in the breast: a case report

    Directory of Open Access Journals (Sweden)

    Adams Simon T

    2009-03-01

    Full Text Available Abstract Introduction Silicone lymphadenopathy is a rare but recognised complication of procedures involving the use of silicone. It has a poorly understood mechanism but is thought to occur following the transportation of silicone particles from silicone-containing prostheses to lymph nodes by macrophages. Case presentation We report of a case involving a 35-year-old woman who presented to the breast clinic with a breast lump and altered sensation below her left nipple 5 years after bilateral cosmetic breast augmentations. A small lump was detected inferior to the nipple but clinical examination and initial ultrasound investigation showed both implants to be intact. However, mammography and magnetic resonance imaging of both breasts revealed both intracapsular and extracapsular rupture of the left breast prosthesis. The patient went on to develop a flu-like illness and tender lumps in the left axilla and right mastoid regions. An excision biopsy of the left axillary lesion and replacement of the ruptured implant was performed. Subsequent histological analysis showed that the axillary lump was a lymph node containing large amounts of silicone. Conclusion The exclusion of malignancy remains the priority when dealing with lumps in the breast or axilla. Silicone lymphadenopathy should however be considered as a differential diagnosis in patients in whom silicone prostheses are present.

  6. Comparison of the AWA lumped-circuit model of electrical discharges with empirical data

    International Nuclear Information System (INIS)

    Maier, W.B. II; Kadish, A.; Robiscoe, R.T.

    1990-01-01

    The authors compare experimental data for three 1.7-m-long transient discharges with an AWA lumped- circuit discharge model in which the arc resistance is taken from the Arc Welder's Ansatz, R a = V*/|I |, where V* is a positive constant and I is the discharge current. In addition to the arc resistance, there is a small series resistance R present in the external circuit. A single value for each of R and V* is deduced from the data, and these values are used to characterize all three discharges. Adequate agreement with the experimental data is obtained; for example, the authors predict the proper number of current reversals for each discharge and abrupt termination of current flow after a finite time. The authors suggest that the AWA lumped circuit provides a better representation of the data than a standard lumped-circuit RLC model and hence is more useful as a tool for prediction and interpretation of discharges

  7. Start-up of belt conveyors used for haulage of large lumps under difficult climatic conditions

    Energy Technology Data Exchange (ETDEWEB)

    Drobny, J

    1979-01-01

    Investigations are discussed carried out by the Research and Development Center for Brown Coal in Most, Czechoslovakia into effects of climate, weather and mass of coal lumps on reliability of belt conveyors in surface mines. Dirt buildup on the driving drums reduces friction and increases belt sliding hazards. Belt wear increases. Driving drum diameter, increased by the buildup, negatively influences load distribution among the electric motors of the drive system. In extreme cases belt wear and irregular load distribution cause belt failures. Methods for buildup removal used in Czechoslovakia and methods for protection of the return side of a conveyor are described. Effects of large mass of coal lumps and ice buildup on large lumps on the risk of belt damage (cuts, punctures etc,) are discussed. Recommendations for design of coal transfer points are made. 2 refs.

  8. Crystallization Formulation Lab

    Data.gov (United States)

    Federal Laboratory Consortium — The Crystallization Formulation Lab fills a critical need in the process development and optimization of current and new explosives and energetic formulations. The...

  9. Characterization of the pharmacokinetics of gasoline using PBPK modeling with a complex mixtures chemical lumping approach.

    Science.gov (United States)

    Dennison, James E; Andersen, Melvin E; Yang, Raymond S H

    2003-09-01

    Gasoline consists of a few toxicologically significant components and a large number of other hydrocarbons in a complex mixture. By using an integrated, physiologically based pharmacokinetic (PBPK) modeling and lumping approach, we have developed a method for characterizing the pharmacokinetics (PKs) of gasoline in rats. The PBPK model tracks selected target components (benzene, toluene, ethylbenzene, o-xylene [BTEX], and n-hexane) and a lumped chemical group representing all nontarget components, with competitive metabolic inhibition between all target compounds and the lumped chemical. PK data was acquired by performing gas uptake PK studies with male F344 rats in a closed chamber. Chamber air samples were analyzed every 10-20 min by gas chromatography/flame ionization detection and all nontarget chemicals were co-integrated. A four-compartment PBPK model with metabolic interactions was constructed using the BTEX, n-hexane, and lumped chemical data. Target chemical kinetic parameters were refined by studies with either the single chemical alone or with all five chemicals together. o-Xylene, at high concentrations, decreased alveolar ventilation, consistent with respiratory irritation. A six-chemical interaction model with the lumped chemical group was used to estimate lumped chemical partitioning and metabolic parameters for a winter blend of gasoline with methyl t-butyl ether and a summer blend without any oxygenate. Computer simulation results from this model matched well with experimental data from single chemical, five-chemical mixture, and the two blends of gasoline. The PBPK model analysis indicated that metabolism of individual components was inhibited up to 27% during the 6-h gas uptake experiments of gasoline exposures.

  10. Steady And Unsteady Lumped-Parameter Models For Determination of Groundwater Residence Time Distribution

    International Nuclear Information System (INIS)

    Oezyurt, N.N.

    2002-01-01

    Groundwater's residence time distribution is an important information to identify the transport mechanism in aquifer systems. In the absence or scarcity of geometric, hydraulic and geohydrologic data needed to describe a flow system, lumped parameter models, that handle the flow system as a whole, exist as an alternative to determine the residence time distribution. Lumped parametre models comprise of idealized models of piston and well-mixed flow and their combinations. Aquifer properties such as, dead volume and by-pass flow can also be included in these models. With the aid of these models, conceptual aquifer models can be tested and residence time distribution of groundwater can be determined

  11. Fission and fusion interaction phenomena of mixed lump kink solutions for a generalized (3+1)-dimensional B-type Kadomtsev-Petviashvili equation

    Science.gov (United States)

    Liu, Yaqing; Wen, Xiaoyong

    2018-05-01

    In this paper, a generalized (3+1)-dimensional B-type Kadomtsev-Petviashvili (gBKP) equation is investigated by using the Hirota’s bilinear method. With the aid of symbolic computation, some new lump, mixed lump kink and periodic lump solutions are derived. Based on the derived solutions, some novel interaction phenomena like the fission and fusion interactions between one lump soliton and one kink soliton, the fission and fusion interactions between one lump soliton and a pair of kink solitons and the interactions between two periodic lump solitons are discussed graphically. Results might be helpful for understanding the propagation of the shallow water wave.

  12. A dimensionless dynamic contrast enhanced MRI parameter for intra-prostatic tumour target volume delineation: initial comparison with histology

    Science.gov (United States)

    Hrinivich, W. Thomas; Gibson, Eli; Gaed, Mena; Gomez, Jose A.; Moussa, Madeleine; McKenzie, Charles A.; Bauman, Glenn S.; Ward, Aaron D.; Fenster, Aaron; Wong, Eugene

    2014-03-01

    Purpose: T2 weighted and diffusion weighted magnetic resonance imaging (MRI) show promise in isolating prostate tumours. Dynamic contrast enhanced (DCE)-MRI has also been employed as a component in multi-parametric tumour detection schemes. Model-based parameters such as Ktrans are conventionally used to characterize DCE images and require arterial contrast agent (CR) concentration. A robust parameter map that does not depend on arterial input may be more useful for target volume delineation. We present a dimensionless parameter (Wio) that characterizes CR wash-in and washout rates without requiring arterial CR concentration. Wio is compared to Ktrans in terms of ability to discriminate cancer in the prostate, as demonstrated via comparison with histology. Methods: Three subjects underwent DCE-MRI using gadolinium contrast and 7 s imaging temporal resolution. A pathologist identified cancer on whole-mount histology specimens, and slides were deformably registered to MR images. The ability of Wio maps to discriminate cancer was determined through receiver operating characteristic curve (ROC) analysis. Results: There is a trend that Wio shows greater area under the ROC curve (AUC) than Ktrans with median AUC values of 0.74 and 0.69 respectively, but the difference was not statistically significant based on a Wilcoxon signed-rank test (p = 0.13). Conclusions: Preliminary results indicate that Wio shows potential as a tool for Ktrans QA, showing similar ability to discriminate cancer in the prostate as Ktrans without requiring arterial CR concentration.

  13. Dimensionless numbers and correlating equations for the analysis of the membrane-gas diffusion electrode assembly in polymer electrolyte fuel cells

    Science.gov (United States)

    Gyenge, E. L.

    The Quraishi-Fahidy method [Can. J. Chem. Eng. 59 (1981) 563] was employed to derive characteristic dimensionless numbers for the membrane-electrolyte, cathode catalyst layer and gas diffuser, respectively, based on the model presented by Bernardi and Verbrugge for polymer electrolyte fuel cells [AIChE J. 37 (1991) 1151]. Monomial correlations among dimensionless numbers were developed and tested against experimental and mathematical modeling results. Dimensionless numbers comparing the bulk and surface-convective ionic conductivities, the electric and viscous forces and the current density and the fixed surface charges, were employed to describe the membrane ohmic drop and its non-linear dependence on current density due to membrane dehydration. The analysis of the catalyst layer yielded electrode kinetic equivalents of the second Damköhler number and Thiele modulus, influencing the penetration depth of the oxygen reduction front based on the pseudohomogeneous film model. The correlating equations for the catalyst layer could describe in a general analytical form, all the possible electrode polarization scenarios such as electrode kinetic control coupled or not with ionic and/or oxygen mass transport limitation. For the gas diffusion-backing layer correlations are presented in terms of the Nusselt number for mass transfer in electrochemical systems. The dimensionless number-based correlating equations for the membrane electrode assembly (MEA) could provide a practical approach to quantify single-cell polarization results obtained under a variety of experimental conditions and to implement them in models of the fuel cell stack.

  14. Dimensionless numbers and correlating equations for the analysis of the membrane-gas diffusion electrode assembly in polymer electrolyte fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Gyenge, E.L. [Department of Chemical and Biological Engineering, The University of British Columbia, 2216 Main Mall, Vancouver, BC (Canada V6T 1Z4)

    2005-12-01

    The Quraishi-Fahidy method [Can. J. Chem. Eng. 59 (1981) 563] was employed to derive characteristic dimensionless numbers for the membrane-electrolyte, cathode catalyst layer and gas diffuser, respectively, based on the model presented by Bernardi and Verbrugge for polymer electrolyte fuel cells [AIChE J. 37 (1991) 1151]. Monomial correlations among dimensionless numbers were developed and tested against experimental and mathematical modeling results. Dimensionless numbers comparing the bulk and surface-convective ionic conductivities, the electric and viscous forces and the current density and the fixed surface charges, were employed to describe the membrane ohmic drop and its non-linear dependence on current density due to membrane dehydration. The analysis of the catalyst layer yielded electrode kinetic equivalents of the second Damkohler number and Thiele modulus, influencing the penetration depth of the oxygen reduction front based on the pseudohomogeneous film model. The correlating equations for the catalyst layer could describe in a general analytical form, all the possible electrode polarization scenarios such as electrode kinetic control coupled or not with ionic and/or oxygen mass transport limitation. For the gas diffusion-backing layer correlations are presented in terms of the Nusselt number for mass transfer in electrochemical systems. The dimensionless number-based correlating equations for the membrane electrode assembly (MEA) could provide a practical approach to quantify single-cell polarization results obtained under a variety of experimental conditions and to implement them in models of the fuel cell stack. (author)

  15. 20 CFR 725.521 - Commutation of payments; lump sum awards.

    Science.gov (United States)

    2010-04-01

    ... present value of future benefit payments commuted, computed at 4 percent true discount compounded annually... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Commutation of payments; lump sum awards. 725.521 Section 725.521 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR...

  16. Simulation of hydrogen deflagration experiment – Benchmark exercise with lumped-parameter codes

    Energy Technology Data Exchange (ETDEWEB)

    Kljenak, Ivo, E-mail: ivo.kljenak@ijs.si [Jožef Stefan Institute, Jamova cesta 39, SI-1000 Ljubljana (Slovenia); Kuznetsov, Mikhail, E-mail: mike.kuznetsov@kit.edu [Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe (Germany); Kostka, Pal, E-mail: kostka@nubiki.hu [NUBIKI Nuclear Safety Research Institute, Konkoly-Thege Miklós út 29-33, 1121 Budapest (Hungary); Kubišova, Lubica, E-mail: lubica.kubisova@ujd.gov.sk [Nuclear Regulatory Authority of the Slovak Republic, Bajkalská 27, 82007 Bratislava (Slovakia); Maltsev, Mikhail, E-mail: maltsev_MB@aep.ru [JSC Atomenergoproekt, 1, st. Podolskykh Kursantov, Moscow (Russian Federation); Manzini, Giovanni, E-mail: giovanni.manzini@rse-web.it [Ricerca sul Sistema Energetico, Via Rubattino 54, 20134 Milano (Italy); Povilaitis, Mantas, E-mail: mantas.p@mail.lei.lt [Lithuania Energy Institute, Breslaujos g.3, 44403 Kaunas (Lithuania)

    2015-03-15

    Highlights: • Blind and open simulations of hydrogen combustion experiment in large-scale containment-like facility with different lumped-parameter codes. • Simulation of axial as well as radial flame propagation. • Confirmation of adequacy of lumped-parameter codes for safety analyses of actual nuclear power plants. - Abstract: An experiment on hydrogen deflagration (Upward Flame Propagation Experiment – UFPE) was proposed by the Jozef Stefan Institute (Slovenia) and performed in the HYKA A2 facility at the Karlsruhe Institute of Technology (Germany). The experimental results were used to organize a benchmark exercise for lumped-parameter codes. Six organizations (JSI, AEP, LEI, NUBIKI, RSE and UJD SR) participated in the benchmark exercise, using altogether four different computer codes: ANGAR, ASTEC, COCOSYS and ECART. Both blind and open simulations were performed. In general, all the codes provided satisfactory results of the pressure increase, whereas the results of the temperature show a wider dispersal. Concerning the flame axial and radial velocities, the results may be considered satisfactory, given the inherent simplification of the lumped-parameter description compared to the local instantaneous description.

  17. 20 CFR 222.31 - Relationship as child for annuity and lump-sum payment purposes.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Relationship as child for annuity and lump... UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Child § 222.31 Relationship as... the employee. For procedures on how a determination of the person's relationship to the employee is...

  18. Lumped Parameter Modeling for Rapid Vibration Response Prototyping and Test Correlation for Electronic Units

    Science.gov (United States)

    Van Dyke, Michael B.

    2013-01-01

    Present preliminary work using lumped parameter models to approximate dynamic response of electronic units to random vibration; Derive a general N-DOF model for application to electronic units; Illustrate parametric influence of model parameters; Implication of coupled dynamics for unit/board design; Demonstrate use of model to infer printed wiring board (PWB) dynamics from external chassis test measurement.

  19. Breast Lumps: A 21‑Year Single‑Center Clinical and Histological ...

    African Journals Online (AJOL)

    Results: Only 38% of the patients came within 3 months of finding lumps in their breast. Onehundred and thirty‑seven patients (83%) had benign disease, i.e., fibroadenoma, mammary dysplasia, cysts, adenomas, tuberculosis, phyllodes tumor, mastitis, and lipoma. Only 16.9% i.e., 28 patients had breast cancer, out of which ...

  20. Advantages and disadvantages of lumping together gastroesophageal reflux disease and dyspepsia

    NARCIS (Netherlands)

    Smout, André J. P. M.

    2006-01-01

    PURPOSE OF REVIEW: The aim of this article is to identify and to balance the arguments in favor of and against lumping together gastroesophageal reflux disease and functional dyspepsia. RECENT FINDINGS: In at least half of the patients diagnosed with gastroesophageal reflux disease no organic

  1. Simulation of hydrogen deflagration experiment – Benchmark exercise with lumped-parameter codes

    International Nuclear Information System (INIS)

    Kljenak, Ivo; Kuznetsov, Mikhail; Kostka, Pal; Kubišova, Lubica; Maltsev, Mikhail; Manzini, Giovanni; Povilaitis, Mantas

    2015-01-01

    Highlights: • Blind and open simulations of hydrogen combustion experiment in large-scale containment-like facility with different lumped-parameter codes. • Simulation of axial as well as radial flame propagation. • Confirmation of adequacy of lumped-parameter codes for safety analyses of actual nuclear power plants. - Abstract: An experiment on hydrogen deflagration (Upward Flame Propagation Experiment – UFPE) was proposed by the Jozef Stefan Institute (Slovenia) and performed in the HYKA A2 facility at the Karlsruhe Institute of Technology (Germany). The experimental results were used to organize a benchmark exercise for lumped-parameter codes. Six organizations (JSI, AEP, LEI, NUBIKI, RSE and UJD SR) participated in the benchmark exercise, using altogether four different computer codes: ANGAR, ASTEC, COCOSYS and ECART. Both blind and open simulations were performed. In general, all the codes provided satisfactory results of the pressure increase, whereas the results of the temperature show a wider dispersal. Concerning the flame axial and radial velocities, the results may be considered satisfactory, given the inherent simplification of the lumped-parameter description compared to the local instantaneous description

  2. BWR MARK I pressure suppression pool mixing and stratification analysis using GOTHIC lumped parameter modeling methodology

    International Nuclear Information System (INIS)

    Ozdemir, Ozkan Emre; George, Thomas L.

    2015-01-01

    As a part of the GOTHIC (GOTHIC incorporates technology developed for the electric power industry under the sponsorship of EPRI.) Fukushima Technical Evaluation project (EPRI, 2014a, b, 2015), GOTHIC (EPRI, 2014c) has been benchmarked against test data for pool stratification (EPRI, 2014a, b, Ozdemir and George, 2013). These tests confirmed GOTHIC’s ability to simulate pool mixing and stratification under a variety of anticipated suppression pool operating conditions. The multidimensional modeling requires long simulation times for events that may occur over a period of hours or days. For these scenarios a lumped model of the pressure suppression chamber is desirable to maintain reasonable simulation times. However, a lumped model for the pool is not able to predict the effects of pool stratification that can influence the overall containment response. The main objective of this work is on the development of a correlation that can be used to estimate pool mixing and stratification effects in a lumped modeling approach. A simplified lumped GOTHIC model that includes a two zone model for the suppression pool with controlled circulation between the upper and lower zones was constructed. A pump and associated flow connections are included to provide mixing between the upper and lower pool volumes. Using numerically generated data from a multidimensional GOTHIC model for the suppression pool, a correlation was developed for the mixing rate between the upper and lower pool volumes in a two-zone, lumped model. The mixing rate depends on the pool subcooling, the steam injection rate and the injection depth

  3. Mixed lump-kink and rogue wave-kink solutions for a (3 + 1) -dimensional B-type Kadomtsev-Petviashvili equation in fluid mechanics

    Science.gov (United States)

    Hu, Cong-Cong; Tian, Bo; Wu, Xiao-Yu; Yuan, Yu-Qiang; Du, Zhong

    2018-02-01

    Under investigation is a (3 + 1) -dimensional B-type Kadomtsev-Petviashvili equation, which describes the weakly dispersive waves in a fluid. Via the Hirota method and symbolic computation, we obtain the mixed lump-kink and mixed rogue wave-kink solutions. Through the mixed lump-kink solutions, we observe three different phenomena between a lump and one kink. For the fusion phenomenon, a lump and a kink are merged with the lump's energy transferring into the kink gradually, until the lump merges into the kink completely. Fission phenomenon displays that a lump separates from a kink. The last phenomenon shows that a lump travels together with a kink with their amplitudes unchanged. In addition, we graphically study the interaction between a rogue wave and a pair of the kinks. It can be observed that the rogue wave arises from one kink and disappears into the other kink. At certain time, the amplitude of the rogue wave reaches the maximum.

  4. Hydrologic classification of rivers based on cluster analysis of dimensionless hydrologic signatures: Applications for environmental instream flows

    Science.gov (United States)

    Praskievicz, S. J.; Luo, C.

    2017-12-01

    Classification of rivers is useful for a variety of purposes, such as generating and testing hypotheses about watershed controls on hydrology, predicting hydrologic variables for ungaged rivers, and setting goals for river management. In this research, we present a bottom-up (based on machine learning) river classification designed to investigate the underlying physical processes governing rivers' hydrologic regimes. The classification was developed for the entire state of Alabama, based on 248 United States Geological Survey (USGS) stream gages that met criteria for length and completeness of records. Five dimensionless hydrologic signatures were derived for each gage: slope of the flow duration curve (indicator of flow variability), baseflow index (ratio of baseflow to average streamflow), rising limb density (number of rising limbs per unit time), runoff ratio (ratio of long-term average streamflow to long-term average precipitation), and streamflow elasticity (sensitivity of streamflow to precipitation). We used a Bayesian clustering algorithm to classify the gages, based on the five hydrologic signatures, into distinct hydrologic regimes. We then used classification and regression trees (CART) to predict each gaged river's membership in different hydrologic regimes based on climatic and watershed variables. Using existing geospatial data, we applied the CART analysis to classify ungaged streams in Alabama, with the National Hydrography Dataset Plus (NHDPlus) catchment (average area 3 km2) as the unit of classification. The results of the classification can be used for meeting management and conservation objectives in Alabama, such as developing statewide standards for environmental instream flows. Such hydrologic classification approaches are promising for contributing to process-based understanding of river systems.

  5. CLINICO PATHOLOGICAL STUDY OF BENIGN BREAST LUMP – A HOSPITAL BASED STUDY

    Directory of Open Access Journals (Sweden)

    Anindita

    2016-03-01

    Full Text Available BACKGROUND Despite the fact that in majority of cases the initial symptom of benign breast disease is a lump, which can be easily detected by the patient herself by self-examination they generally present at a very late stage and this poses a great difficulty in their management. Early and appropriate diagnosis of breast disease is of utmost importance. AIM The aim of the study was to find out the relative frequency and commonest site of occurrence of benign breast disorder and their relationship with age, parity, menstrual cycle, and socio-economic status and also to find out the accuracy of investigative procedures in their diagnosis. DESIGN This is a cross sectional, interventional. Hospital based study. MATERIALS AND METHOD This study was done in 58 female patients in the age group 10 yrs. to 55 yrs. presenting with clinically benign breast lumps randomly chosen from outpatient department and indoor wards of The Calcutta Medical Research Institute, Kolkata. After taking an accurate history and proper clinical examination these patients were sequentially studied by radiological methods (Ultrasonography and mammography, fine needle aspiration cytology (FNAC and histopathology of removed specimen. Patients were enquired about their age, chief complaints, menstrual history, and use of oral pill, marital status, parity, lactation and socioeconomic status. RESULTS 79% of the benign breast lumps were found to be between 10–35 years, Fibro adenoma being the commonest one (41.38% and fibrocystic disease the second most common (29.31%. Breast lump were more common among unmarried and nulliparous females (48.27%, commonest site being upper and outer quadrant (38.8%. 69% patients were associated with an abnormal menstrual status. 76% of the cases were accurately diagnosed by clinical examination, 70% by mammography, 88% by FNAC and 84% by ultrasonography. CONCLUSION This clinicopathological study of benign breast lump is a small endeavour on our part

  6. An Integrated Lumped Parameter-CFD approach for off-design ejector performance evaluation

    International Nuclear Information System (INIS)

    Besagni, Giorgio; Mereu, Riccardo; Chiesa, Paolo; Inzoli, Fabio

    2015-01-01

    Highlights: • We validate a CFD approach for a convergent nozzle ejector using global and local measurement. • We evaluate seven RANS turbulence models for convergent nozzle ejector. • We introduce a lumped parameter model for on-design and off-design ejector performance evaluation. • We analyze the relationship between local flow behavior and lumped parameters of the model. • We discuss how to improve predicting capabilities of the model by variable parameters calibrated on CFD simulations. - Abstract: This paper presents an Integrated Lumped Parameter Model-Computational Fluid-Dynamics approach for off-design ejector performance evaluation. The purpose of this approach is to evaluate the entrainment ratio, for a fixed geometry, in both on-design and off-design operating conditions. The proposed model is based on a Lumped Parameter Model (LPM) with variable ejector component efficiencies provided by CFD simulations. The CFD results are used for developing maps for ejector component efficiencies in a broad range of operating conditions. The ejector component efficiency maps couple the CFD and the LPM techniques for building an Integrated LPM-CFD approach. The proposed approach is demonstrated for a convergent nozzle ejector and the paper is structured in four parts. At first, the CFD approach is validated by global and local data and seven Reynolds Averaged Navier Stokes (RANS) turbulence models are compared: the k–ω SST showed good performance and was selected for the rest of the analysis. At second, a Lumped Parameter Model (LPM) for subsonic ejector is developed and the ejector component efficiencies have been defined. At third, the CFD approach is used to investigate the flow field, to analyze its influence on ejector component efficiencies and to propose efficiency correlations and maps linking ejector component efficiencies and local flow quantities. In the last part, the efficiency maps are embedded into the lumped parameter model, thus creating

  7. Development of a transient, lumped hydrologic model for geomorphologic units in a geomorphology based rainfall-runoff modelling framework

    Science.gov (United States)

    Vannametee, E.; Karssenberg, D.; Hendriks, M. R.; de Jong, S. M.; Bierkens, M. F. P.

    2010-05-01

    We propose a modelling framework for distributed hydrological modelling of 103-105 km2 catchments by discretizing the catchment in geomorphologic units. Each of these units is modelled using a lumped model representative for the processes in the unit. Here, we focus on the development and parameterization of this lumped model as a component of our framework. The development of the lumped model requires rainfall-runoff data for an extensive set of geomorphological units. Because such large observational data sets do not exist, we create artificial data. With a high-resolution, physically-based, rainfall-runoff model, we create artificial rainfall events and resulting hydrographs for an extensive set of different geomorphological units. This data set is used to identify the lumped model of geomorphologic units. The advantage of this approach is that it results in a lumped model with a physical basis, with representative parameters that can be derived from point-scale measurable physical parameters. The approach starts with the development of the high-resolution rainfall-runoff model that generates an artificial discharge dataset from rainfall inputs as a surrogate of a real-world dataset. The model is run for approximately 105 scenarios that describe different characteristics of rainfall, properties of the geomorphologic units (i.e. slope gradient, unit length and regolith properties), antecedent moisture conditions and flow patterns. For each scenario-run, the results of the high-resolution model (i.e. runoff and state variables) at selected simulation time steps are stored in a database. The second step is to develop the lumped model of a geomorphological unit. This forward model consists of a set of simple equations that calculate Hortonian runoff and state variables of the geomorphologic unit over time. The lumped model contains only three parameters: a ponding factor, a linear reservoir parameter, and a lag time. The model is capable of giving an appropriate

  8. Method for Lumped Parameter simulation of Digital Displacement pumps/motors based on CFD

    DEFF Research Database (Denmark)

    Rømer, Daniel; Johansen, Per; Pedersen, Henrik C.

    2013-01-01

    Digital displacement fluid power pumps/motors offers improved efficiency and performance compared to traditional variable displacement pump/motors. These improvements are made possible by using efficient electronically controlled seat valves and careful design of the flow geometry. To optimize...... the design and control of digital displacement machines, there is a need for simulation models, preferably models with low computational cost. Therefore, a low computational cost generic lumped parameter model of digital displacement machine is presented, including a method for determining the needed model...... parameters based on steady CFD results, in order to take detailed geometry information into account. The response of the lumped parameter model is compared to a computational expensive transient CFD model for an example geometry....

  9. A Novel T-Fed 4-Element Quasi-Lumped Resonator Antenna Array

    Directory of Open Access Journals (Sweden)

    S.S. Olokede

    2014-06-01

    Full Text Available In this paper, electrically small corporately T-fed quasi-lumped element resonator antenna array is investigated. The radiating element, a quasi-lumped element resonator is excited by a novel semi hybrid ring-like T-shaped corporate feed network. The characteristics losses due to Ohmic and discontinuities along the feed line which invariably constitutes complex feed structures are mitigated at the instance of the proposed antenna. Technique to implement the compact array with the intent to enhance the gain is presented. The operation dynamics of the feed along with its theoretical explanation is also reported. Findings indicates that the measured gain is 10.97 dBi for antenna of an estate area of about 0.677λ_0 × 1.257λ_0 sq. mm. Valuable insight to the optimum design in terms of compactness, good gain, and ease of fabrication is documented.

  10. A Lumped Thermal Model Including Thermal Coupling and Thermal Boundary Conditions for High Power IGBT Modules

    DEFF Research Database (Denmark)

    Bahman, Amir Sajjad; Ma, Ke; Blaabjerg, Frede

    2018-01-01

    Detailed thermal dynamics of high power IGBT modules are important information for the reliability analysis and thermal design of power electronic systems. However, the existing thermal models have their limits to correctly predict these complicated thermal behavior in the IGBTs: The typically used...... thermal model based on one-dimensional RC lumps have limits to provide temperature distributions inside the device, moreover some variable factors in the real-field applications like the cooling and heating conditions of the converter cannot be adapted. On the other hand, the more advanced three......-dimensional thermal models based on Finite Element Method (FEM) need massive computations, which make the long-term thermal dynamics difficult to calculate. In this paper, a new lumped three-dimensional thermal model is proposed, which can be easily characterized from FEM simulations and can acquire the critical...

  11. Intense deuterium nuclear fusion of pycnodeuterium-lumps coagulated locally within highly deuterated atom clusters

    CERN Document Server

    Yoshiaki, A; Zhang, Y C

    2002-01-01

    Embedded nano-Pd particles of 5 nm in size instantly abundant D-atoms more than 250% in the atomic ratio against Pd-atoms at room temperature when they are kept in D sub 2 gas pressurized to less than 10 atm. In such ultrahigh densities, 2-4 D-atoms can be coagulated inside each octahedral space of Pd lattice (pycnodeuterium-lump). When a stimulation energy such as latticequake causing by ultrasonic wave was supplied to those highly deuterated Pd particles, intense deuterium nuclear fusion (''solid fusion'') was generated there and both excess heat and sup 4 He gas were abundantly produced. Naturally, these facts can not be realized at all in bulk Pd. The results show that the nuclear fusion occurs without any hazardous rays in pycnodeuterium-lumps coagulated locally inside the each cell of the host metal lattice. These unit cells correspond to minimum unit of the solid fusion reactor as a ''Lattice Reactor''. (author)

  12. The effect of environmental factors on breast lumps of Egyptian women in different socioeconomic levels

    International Nuclear Information System (INIS)

    Salama, D.H.

    2008-01-01

    The environmental risk factors related to the breast tumors (lumps) are essential in order to build strategies to decrease cancer incidence and mortality among different socioeconomic and cultural backgrounds. A case control study of 70 cases and 52 controls were classified into high, middle and low socioeconomic classes. The results revealed significant increased risk of breast tumors among working females, having positive family history, married with lower mean parity, with higher consumption of fatty meals, lesser meat intake. Non significant risk factors were the social class, exposure to ionizing radiation, non lactating. wearing tight bra, consumption of vegetables and fruits, oral contraceptive pill users and exposure to outdoor air pollution or indoor pollution as floors and wall paintings. In conclusion, this study highlights the positive life style for egyptian women so they can prevent some of the environmental risks of breast tumors. Increasing the awareness of breast diseases and regular examination remains the corner stone for early detection management of breast lumps.

  13. Lumped-parameter modeling of PWR downcomer and pressurizer for LOCA conditions

    International Nuclear Information System (INIS)

    Rohatgi, U.S.; Saha, P.; Dubow, A.A.

    1978-01-01

    Two lumped-parameter models, one for a PWR downcomer and the other for a pressurizer, are presented. The models are based on the transient, nonhomogeneous, drift-flux description of two-phase flow, and are suitable for simulating a hypothetical LOCA condition. Effects of thermal nonequilibrium are incorporated in the downcomer model, whereas the pressurizer model can track the interfaces among various flow regimes. Semiimplicit numerical schemes are used for solution. Encouraging results have been obtained for both the models. (author)

  14. Lumped hydrological models is an Occam' razor for runoff modeling in large Russian Arctic basins

    OpenAIRE

    Ayzel Georgy

    2018-01-01

    This study is aimed to investigate the possibility of three lumped hydrological models to predict daily runoff of large-scale Arctic basins for the modern period (1979-2014) in the case of substantial data scarcity. All models were driven only by meteorological forcing reanalysis dataset without any additional information about landscape, soil or vegetation cover properties of studied basins. We found limitations of model parameters calibration in ungauged basins using global optimization alg...

  15. Determination of heat flows inside turbochargers by means of a one dimensional lumped model

    OpenAIRE

    Olmeda González, Pablo Cesar; Dolz Ruiz, Vicente; Arnau Martínez, Francisco José; Reyes Belmonte, Miguel Angel

    2013-01-01

    In the present paper, a methodology to calculate the heat fluxes inside a turbocharger from diesel passenger car is presented. The heat transfer phenomenon is solved by using a one dimensional lumped model that takes into account both the heat fluxes between the different turbocharger elements, as well as the heat fluxes between the working fluids and the turbocharger elements. This heat transfer study is supported by the high temperature differences between the working fluids passing thr...

  16. A Size Reduction Technique for Mobile Phone PIFA Antennas Using Lumped Inductors

    DEFF Research Database (Denmark)

    Thaysen, Jesper; Jakobsen, Kaj Bjarne

    2005-01-01

    A size reduction technique for the planar inverted-F antenna (PIFA) is presented. An 18 nH lumped inductor is used in addition to a small 0.3 cm3 PIFA. The PIFA is located on dielectric foam, 5 mm above a 40 mm × 100 mm ground plane. It is possible to reduce the center frequency (|S11|min) by 33 ...

  17. Painless lump over the forehead which turned painful: an unusual presentation of hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    S P Susheela

    2015-05-01

    Full Text Available Hepatocellular carcinoma (HCC is one of the most common malignancies and is known to most often present with symptomatology pertaining to local hepatic disease. Although HCC is known to metastasize to lungs, abdominal lymph nodes, adrenal glands and the vertebral column, it is rather rare to come across patients with skull metastasis. The manifestation of a solitary frontal bone metastasis leading to a painless lump over the forehead as the initial presenting feature of HCC is highly unusual. This case report pertains to a 40-year-old male patient who had initially observed a painless lump over his forehead that was gradually increasing in size over a span of 3 months. He sought medical attention when, after several months, the "painless lump" suddenly became painful. Investigations revealed the involvement of both the outer and the inner table of the frontal bone, and a biopsy revealed the histopathology to be that of HCC. On further investigation, he was found to have systemic disseminated disease involving both the left and right lungs and vertebrae and treatment was initiated with sorafenib. Despite an initial partial response, the patient subsequently succumbed to hepatic failure. This case report illustrates the fact that HCC can silently progress, and even lead to dissemination and distant metastases before becoming clinically evident.

  18. A Calibrated Lumped Element Model for the Prediction of PSJ Actuator Efficiency Performance

    Directory of Open Access Journals (Sweden)

    Matteo Chiatto

    2018-03-01

    Full Text Available Among the various active flow control techniques, Plasma Synthetic Jet (PSJ actuators, or Sparkjets, represent a very promising technology, especially because of their high velocities and short response times. A practical tool, employed for design and manufacturing purposes, consists of the definition of a low-order model, lumped element model (LEM, which is able to predict the dynamic response of the actuator in a relatively quick way and with reasonable fidelity and accuracy. After a brief description of an innovative lumped model, this work faces the experimental investigation of a home-designed and manufactured PSJ actuator, for different frequencies and energy discharges. Particular attention has been taken in the power supply system design. A specific home-made Pitot tube has allowed the detection of velocity profiles along the jet radial direction, for various energy discharges, as well as the tuning of the lumped model with experimental data, where the total device efficiency has been assumed as a fitting parameter. The best fitting value not only contains information on the actual device efficiency, but includes some modeling and experimental uncertainties, related also to the used measurement technique.

  19. Incidence data for breast cancer among Yemeni female patients with palpable breast lumps.

    Science.gov (United States)

    Alsanabani, Jamila Ali; Gilan, Waleed; Saadi, Azzan Al

    2015-01-01

    To estimate the incidence of breast cancer in Yemeni female patients presenting with a breast mass. This retrospective study was carried out with 595 female patients with palpable breast lumps, attending to Alkuwait university hospital, Sana'a, Yemen. Triple assessment, including breast examination, mammography and biopsy (FNAC, core needle, or excision), for all patients were performed. The incidences of benign and malignant lesions was calculated. Some 160 (26.9%) of 595 patients had malignancies; 213 (35.8%) were fibroadenomas; 12 (2.0%) were fibrocystic change; 143 (24.03%) were inflammatory lesions (including mastitis and ductectasia); 62 (10.4%) were simple cysts, while 5 (0.8%) were phyllodes tumors. The mean age of patients with malignant lumps was 44.3 years. Among Yemeni female patients with palpable breast lumps, the rate of breast cancer is high, with occurrence at an earlier age than in Western countries. Improving breast cancer awareness programs and increasing breast cancer screening centers inb different areas of Yemen are needed to establish early diagnosis and offer early and optimal treatment.

  20. Numerical analysis of the resonance mechanism of the lumped parameter system model for acoustic mine detection

    International Nuclear Information System (INIS)

    Wang Chi; Zhou Yu-Qiu; Shen Gao-Wei; Wu Wen-Wen; Ding Wei

    2013-01-01

    The method of numerical analysis is employed to study the resonance mechanism of the lumped parameter system model for acoustic mine detection. Based on the basic principle of the acoustic resonance technique for mine detection and the characteristics of low-frequency acoustics, the ''soil-mine'' system could be equivalent to a damping ''mass-spring'' resonance model with a lumped parameter analysis method. The dynamic simulation software, Adams, is adopted to analyze the lumped parameter system model numerically. The simulated resonance frequency and anti-resonance frequency are 151 Hz and 512 Hz respectively, basically in agreement with the published resonance frequency of 155 Hz and anti-resonance frequency of 513 Hz, which were measured in the experiment. Therefore, the technique of numerical simulation is validated to have the potential for analyzing the acoustic mine detection model quantitatively. The influences of the soil and mine parameters on the resonance characteristics of the soil—mine system could be investigated by changing the parameter setup in a flexible manner. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  1. Experimental Verification of Guided-Wave Lumped Circuits Using Waveguide Metamaterials

    Science.gov (United States)

    Li, Yue; Zhang, Zhijun

    2018-04-01

    Through the construction and characterization in microwave frequencies, we experimentally demonstrate our recently developed theory of waveguide lumped circuits, i.e., waveguide metatronics [Sci. Adv. 2, e1501790 (2016), 10.1126/sciadv.1501790], as a method to design subwavelength-scaled analog circuits. In the paradigm of waveguide metatronics, numbers of lumped inductors and capacitors are easily integrated functionally inside the waveguide, which is an irreplaceable transmission line in millimeter-wave and terahertz systems with the advantages of low radiation loss and low crosstalk. An example of multiple-ordered metatronic filters with layered structures is fabricated utilizing the technique of substrate integrated waveguides, which can be easily constructed by the printed-circuit-board process. The materials used in the construction are also typical microwave materials with positive permittivity, low loss, and negligible dispersion, imitating the plasmonic materials with negative permittivity in the optical domain. The results verify the theory of waveguide metatronics, which provides an efficient platform of functional lumped circuit design for guided-wave processing.

  2. Definition of datum of materials lump size on conveyors by means of reflected gamma-radiation method

    International Nuclear Information System (INIS)

    Gal'yanov, A.V.; Antonov, V.A.; Laptev, Yu.V.

    2001-01-01

    A method of technological control of large-size lumps in conveyor-transported crushed material based on intensity measurement of X-ray and gamma radiation reflected from the material surface was suggested. The method was substantiated theoretically and as a result it was shown that dispersion of radiation intensity, multiply measured for short periods of time, can be analytic parameter of large-size lumps yield. Principled methodical and design recommendations on the method practical applications are given [ru

  3. Flexible hydrological modeling - Disaggregation from lumped catchment scale to higher spatial resolutions

    Science.gov (United States)

    Tran, Quoc Quan; Willems, Patrick; Pannemans, Bart; Blanckaert, Joris; Pereira, Fernando; Nossent, Jiri; Cauwenberghs, Kris; Vansteenkiste, Thomas

    2015-04-01

    Based on an international literature review on model structures of existing rainfall-runoff and hydrological models, a generalized model structure is proposed. It consists of different types of meteorological components, storage components, splitting components and routing components. They can be spatially organized in a lumped way, or on a grid, spatially interlinked by source-to-sink or grid-to-grid (cell-to-cell) routing. The grid size of the model can be chosen depending on the application. The user can select/change the spatial resolution depending on the needs and/or the evaluation of the accuracy of the model results, or use different spatial resolutions in parallel for different applications. Major research questions addressed during the study are: How can we assure consistent results of the model at any spatial detail? How can we avoid strong or sudden changes in model parameters and corresponding simulation results, when one moves from one level of spatial detail to another? How can we limit the problem of overparameterization/equifinality when we move from the lumped model to the spatially distributed model? The proposed approach is a step-wise one, where first the lumped conceptual model is calibrated using a systematic, data-based approach, followed by a disaggregation step where the lumped parameters are disaggregated based on spatial catchment characteristics (topography, land use, soil characteristics). In this way, disaggregation can be done down to any spatial scale, and consistently among scales. Only few additional calibration parameters are introduced to scale the absolute spatial differences in model parameters, but keeping the relative differences as obtained from the spatial catchment characteristics. After calibration of the spatial model, the accuracies of the lumped and spatial models were compared for peak, low and cumulative runoff total and sub-flows (at downstream and internal gauging stations). For the distributed models, additional

  4. Breast lump

    Science.gov (United States)

    ... with milk). These cysts can occur with breastfeeding. Breast abscess . These typically occur if you are breastfeeding or ... Breast infections are treated with antibiotics. Sometimes a breast abscess needs to be drained with a needle or ...

  5. Suitability of different formulated carriers for sustaining microbial shelf life

    International Nuclear Information System (INIS)

    Tabassam, T.; Ali, A.

    2014-01-01

    Non-availability of a suitable carrier for bioinnoculant is a serious constraint for dissemination of biofertilizer technology in Pakistan. Present study was designed to formulate a suitable carrier from locally available cheap material and evaluate for shelf life by using locally isolated plant growth promoting rhizobacteria (PGPR) strains from maize rhizosphere. Different combinations of material were prepared using clay soil (35-50%), fly-ash (30-45%), press mud (5-15%) and lignite (5-15%). Clay soil (53% clay) was used for adhesion purpose but considering free of lump formation an important property of a good carrier, mixing 40% of soil with other material was found suitable. Using 40% of soil, six different treatments were formulated and physico-chemical characteristics were determined. Four combinations in the range of 40% clay, 30-40% fly-ash, 10-15% press mud and 10-15% lignitic coal were selected which had good adhesion capacity, moisture holding capacity, nutrient contents and investigated for microbial shelf life. Significant difference regarding microbial survival was observed between different formulations as well as between different incubation intervals. Among different carrier tested the FC-4 supported the maximum population of 33.5x10- 10.8x10 cfu g for MR-8 and 32.6x10 - 7.2x10 cfu g for MR-5. Results showed that the required population of PGPR was sustained in all the formulation tested up to six months of storage period. (author)

  6. Study of Pellets and Lumps as Raw Materials in Silicon Production from Quartz and Silicon Carbide

    Science.gov (United States)

    Dal Martello, E.; Tranell, G.; Gaal, S.; Raaness, O. S.; Tang, K.; Arnberg, L.

    2011-10-01

    The use of high-purity carbon and quartz raw materials reduces the need for comprehensive refining steps after the silicon has been produced carbothermically in the electric reduction furnace. The current work aims at comparing the reaction mechanisms and kinetics occurring in the inner part of the reduction furnace when pellets or lumpy charge is used, as well as the effect of the raw material mix. Laboratory-scale carbothermic reduction experiments have been carried out in an induction furnace. High-purity silicon carbide and two different high-purity hydrothermal quartzes were charged as raw materials at different molar ratios. The charge was in the form of lumps (size, 2-5 mm) or as powder (size, 10-20 μm), mixed and agglomerated as pellets (size, 1-3 mm) and reacted at 2273 K (2000 °C). The thermal properties of the quartzes were measured also by heating a small piece of quartz in CO atmosphere. The investigated quartzes have different reactivity in reducing atmosphere. The carbothermal reduction experiments show differences in the reacted charge between pellets and lumps as charge material. Solid-gas reactions take place from the inside of the pellets porosity, whereas reactions in lumps occur topochemically. Silicon in pellets is produced mainly in the rim zone. Larger volumes of silicon have been found when using lumpy charge. More SiO is produced when using pellets than for lumpy SiO2 for the same molar ratio and heating conditions. The two SiC polytypes used in the carbothermal reduction experiments as carbon reductants presented different reactivity.

  7. Simultaneous release of diclofenac sodium and papaverine hydrochloride from tablets and pellets using the flow-through cell apparatus described by dimensionless equations.

    Science.gov (United States)

    Kasperek, Regina

    2011-01-01

    The release of diclofenac sodium and papaverine hydrochloride from tablets and pellets using the flow-through cell apparatus was studied. The influence of excipients and of a size of the solid dosage forms on the amount of the released substances at the intervals of time using the different rates of flow of the dissolution medium was investigated. Physical parameters corresponding to the dissolution process as the mass transfer coefficient, the thickness of the boundary diffusion layer and the concentration of the saturated solution at this layer were calculated. The results of release were described by dimensionless equations.

  8. Mass-Inertial Characteristics and Dimensionless Equations of Two-bearing Rotor Motion with Auto-balancer in Terms of Compensating Body Mass

    Directory of Open Access Journals (Sweden)

    A. N. Gorbenko

    2015-01-01

    Full Text Available Modern rotary machines use auto-balancing devices of passive type to provide automatic balancing of rotors and reduce vibration. Most available researches on the rotor auto-balancing dynamics and stability are based on the assumption that the compensating bodies of the autobalancer, as well as the rotor imbalance, are infinitesimal values. The literature review has shown that the problems concerning the automatic balancing of rotor with its three-dimensional motion are solved approximately and require an in-depth analysis taking into consideration the final mass of the compensating bodies.The paper analyses the effect of an auto-balancer mass on the mass-inertial properties of the three-dimensional rotor motion. It gives the autonomous equations of the system motion. The work shows that attaching the point masses of compensating auto-balancer bodies and imbalance to the rotor causes an increase, however non-identical, in all components of the total inertia tensor of the mechanical system. This leads to a qualitative change in mass-inertial characteristics of the system.The composite rotor becomes an inertia anisotropic body in which the inertia moments about the two transverse own axes are not equal to each other. The rotor anisotropy results in complicated dynamic behavior of the gyroscopic rotor. In this case, the additional critical rotor speeds and the zones of instability of motion may occur.It is shown that in the case of using multi-body auto-balancer the inertial parameters of the rotor system grow into the interval values, i.e. their values are not uniquely determined and may be equal to a variety values from a certain range. Thus, the degree of inertial anisotropy and other auto-balancing parameters are the interval values as well in this case.The system of dimensionless equations of rotary machine motion, which contains the minimum required number of dimensionless parameters, has been obtained. The specific ranges of the dimensionless

  9. Audits of radiopharmaceutical formulations

    International Nuclear Information System (INIS)

    Castronovo, F.P. Jr.

    1992-01-01

    A procedure for auditing radiopharmaceutical formulations is described. To meet FDA guidelines regarding the quality of radiopharmaceuticals, institutional radioactive drug research committees perform audits when such drugs are formulated away from an institutional pharmacy. All principal investigators who formulate drugs outside institutional pharmacies must pass these audits before they can obtain a radiopharmaceutical investigation permit. The audit team meets with the individual who performs the formulation at the site of drug preparation to verify that drug formulations meet identity, strength, quality, and purity standards; are uniform and reproducible; and are sterile and pyrogen free. This team must contain an expert knowledgeable in the preparation of radioactive drugs; a radiopharmacist is the most qualified person for this role. Problems that have been identified by audits include lack of sterility and apyrogenicity testing, formulations that are open to the laboratory environment, failure to use pharmaceutical-grade chemicals, inadequate quality control methods or records, inadequate training of the person preparing the drug, and improper unit dose preparation. Investigational radiopharmaceutical formulations, including nonradiolabeled drugs, must be audited before they are administered to humans. A properly trained pharmacist should be a member of the audit team

  10. New Procedure to Develop Lumped Kinetic Models for Heavy Fuel Oil Combustion

    KAUST Repository

    Han, Yunqing

    2016-09-20

    A new procedure to develop accurate lumped kinetic models for complex fuels is proposed, and applied to the experimental data of the heavy fuel oil measured by thermogravimetry. The new procedure is based on the pseudocomponents representing different reaction stages, which are determined by a systematic optimization process to ensure that the separation of different reaction stages with highest accuracy. The procedure is implemented and the model prediction was compared against that from a conventional method, yielding a significantly improved agreement with the experimental data. © 2016 American Chemical Society.

  11. Advertising Pricing Models in Media Markets: Lump-Sum versus Per-Consumer Charges

    OpenAIRE

    Helmut Dietl; Markus Lang; Panlang Lin

    2012-01-01

    This paper develops a model of asymmetric competition between a pay and a free media platform. The pay media platform generates revenues from media consumers through subscription fees, while the free media platform generates revenues from charging advertisers either on a lump-sum basis (regime A) or on a per-consumer basis (regime B). We show that the free platform produces a higher advertising level and attracts more consumers in regime A than B although advertisers must pay more for ads and...

  12. Cultural factors associated with the management of breast lumps amongst Xhosa women

    Directory of Open Access Journals (Sweden)

    Nosipho Mdondolo

    2003-11-01

    Full Text Available A qualitative research design and an ethno-nursing research method were used to identify cultural factors influencing Xhosa women’s health seeking behaviours associated with breast lumps. Opsomming ’n Kwalitatiewe navorsingsontwerp en ’n etnoverpleegkundige navorsingsmetode is gebruik. Die doel was om te bepaal watter kulturele faktore Xhosa vroue se strewe na welstand, wat in verband staan met ’n borsvergroeisel, beïnvloed. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

  13. Reactive decontamination formulation

    Science.gov (United States)

    Giletto, Anthony [College Station, TX; White, William [College Station, TX; Cisar, Alan J [Cypress, TX; Hitchens, G Duncan [Bryan, TX; Fyffe, James [Bryan, TX

    2003-05-27

    The present invention provides a universal decontamination formulation and method for detoxifying chemical warfare agents (CWA's) and biological warfare agents (BWA's) without producing any toxic by-products, as well as, decontaminating surfaces that have come into contact with these agents. The formulation includes a sorbent material or gel, a peroxide source, a peroxide activator, and a compound containing a mixture of KHSO.sub.5, KHSO.sub.4 and K.sub.2 SO.sub.4. The formulation is self-decontaminating and once dried can easily be wiped from the surface being decontaminated. A method for decontaminating a surface exposed to chemical or biological agents is also disclosed.

  14. Preparation of radiopharmaceutical formulations

    International Nuclear Information System (INIS)

    Simon, J.; Garlich, J.R.; Frank, R.K.; McMillan, K.

    1998-01-01

    Radiopharmaceutical formulations for complexes comprising at least one radionuclide complexed with a ligand, or its physiologically-acceptable salts thereof, especially 153 samarium-ethylenediaminetetramethylenephosphonic acid, which optionally contains a divalent metal ion, e.g. calcium, and is frozen, thawed, and then administered by injection. Alternatively, the radiopharmaceutical formulations must contain the divalent metal and are frozen only if the time before administration is sufficiently long to cause concern for radiolysis of the ligand. 2 figs., 9 tabs

  15. Tariff formulation and equalization

    International Nuclear Information System (INIS)

    Svartsund, Trond

    2003-01-01

    The primary goal of the transmission tariff is to provide for socioeconomic use of the transmission grid. The present tariff structure is basically right. The responsibility for the formulation of the tariff resides with the local grid owner. This must take place in agreement with the current regulations which are passed by the authorities. The formulation must be adaptable to the local requirements. EBL (Norwegian Electricity Industry Association) is content with the current regulations

  16. Dimensionless parameterization of lidar for laser remote sensing of the atmosphere and its application to systems with SiPM and PMT detectors.

    Science.gov (United States)

    Agishev, Ravil; Comerón, Adolfo; Rodriguez, Alejandro; Sicard, Michaël

    2014-05-20

    In this paper, we show a renewed approach to the generalized methodology for atmospheric lidar assessment, which uses the dimensionless parameterization as a core component. It is based on a series of our previous works where the problem of universal parameterization over many lidar technologies were described and analyzed from different points of view. The modernized dimensionless parameterization concept applied to relatively new silicon photomultiplier detectors (SiPMs) and traditional photomultiplier (PMT) detectors for remote-sensing instruments allowed predicting the lidar receiver performance with sky background available. The renewed approach can be widely used to evaluate a broad range of lidar system capabilities for a variety of lidar remote-sensing applications as well as to serve as a basis for selection of appropriate lidar system parameters for a specific application. Such a modernized methodology provides a generalized, uniform, and objective approach for evaluation of a broad range of lidar types and systems (aerosol, Raman, DIAL) operating on different targets (backscatter or topographic) and under intense sky background conditions. It can be used within the lidar community to compare different lidar instruments.

  17. Compensation of the magnetization current induced sextupole error at LHC injection field by short lumped permanent sextupole magnets, incorporated into the end configuration of superconducting dipoles

    CERN Document Server

    Asner, A

    1985-01-01

    Compensation of the magnetization current induced sextupole error at LHC injection field by short lumped permanent sextupole magnets, incorporated into the end configuration of superconducting dipoles

  18. Acute lymphoblastic leukemia presenting as a breast lump: A report of two cases

    Directory of Open Access Journals (Sweden)

    Syed Besina

    2013-01-01

    Full Text Available Extra-medullary leukemic infiltration of the breast by acute lymphoblastic leukemia (ALL is very rare. We report two cases of ALL presenting as breast masses and diagnosed on fine-needle aspiration (FNA. Our first patient, a post-partum 30-year-old female, developed bilateral breast lumps in her last trimester of pregnancy and complained of easy fatigability. Our second patient, a 14-year-old girl, presented with a right-breast lump of 1-week duration. She had received treatment for ALL 1 year back and had been in complete remission for the last 1 year. FNA of the breast nodules done in both the cases revealed diffuse infiltration by lymphoblasts. Subsequent hematological investigations confirmed bone marrow involvement by ALL in the first case and extra-medullary relapse in the second case. Fine-needle aspiration cytology (FNAC is an easy and cost effective method for the early diagnosis of metastatic leukemic infiltration, avoiding unnecessary excisional biopsies in such cases.

  19. Comparing sensitivity analysis methods to advance lumped watershed model identification and evaluation

    Directory of Open Access Journals (Sweden)

    Y. Tang

    2007-01-01

    Full Text Available This study seeks to identify sensitivity tools that will advance our understanding of lumped hydrologic models for the purposes of model improvement, calibration efficiency and improved measurement schemes. Four sensitivity analysis methods were tested: (1 local analysis using parameter estimation software (PEST, (2 regional sensitivity analysis (RSA, (3 analysis of variance (ANOVA, and (4 Sobol's method. The methods' relative efficiencies and effectiveness have been analyzed and compared. These four sensitivity methods were applied to the lumped Sacramento soil moisture accounting model (SAC-SMA coupled with SNOW-17. Results from this study characterize model sensitivities for two medium sized watersheds within the Juniata River Basin in Pennsylvania, USA. Comparative results for the 4 sensitivity methods are presented for a 3-year time series with 1 h, 6 h, and 24 h time intervals. The results of this study show that model parameter sensitivities are heavily impacted by the choice of analysis method as well as the model time interval. Differences between the two adjacent watersheds also suggest strong influences of local physical characteristics on the sensitivity methods' results. This study also contributes a comprehensive assessment of the repeatability, robustness, efficiency, and ease-of-implementation of the four sensitivity methods. Overall ANOVA and Sobol's method were shown to be superior to RSA and PEST. Relative to one another, ANOVA has reduced computational requirements and Sobol's method yielded more robust sensitivity rankings.

  20. A lumped-parameter model for cryo-adsorber hydrogen storage tank

    Energy Technology Data Exchange (ETDEWEB)

    Senthil Kumar, V.; Raghunathan, K. [India Science Lab, General Motors R and D, Creator Building, International Technology Park, Bangalore 560066 (India); Kumar, Sudarshan [Chemical and Environmental Sciences Lab, General Motors R and D, 30500 Mound Road, Warren, MI 48090 (United States)

    2009-07-15

    One of the primary requirements for commercialization of hydrogen fuel-cell vehicles is the on-board storage of hydrogen in sufficient quantities. On-board storage of hydrogen by adsorption on nano-porous adsorbents at around liquid nitrogen temperatures and moderate pressures is considered viable and competitive with other storage technologies: liquid hydrogen, compressed gas, and metallic or complex hydrides. The four cryo-adsorber fuel tank processes occur over different time scales: refueling over a few minutes, discharge over a few hours, dormancy over a few days, and venting over a few weeks. The slower processes i.e. discharge, dormancy and venting are expected to have negligible temperature gradients within the bed, and hence are amenable to a lumped-parameter analysis. Here we report a quasi-static lumped-parameter model for the cryo-adsorber fuel tank, and discuss the results for these slower processes. We also describe an alternative solution method for dormancy and venting based on the thermodynamic state description. (author)

  1. Modelling of nonhomogeneous atmosphere in NPP containment using lumped-parameter model based on CFD calculations

    International Nuclear Information System (INIS)

    Kljenak, I.; Mavko, B.; Babic, M.

    2005-01-01

    Full text of publication follows: The modelling and simulation of atmosphere mixing and stratification in nuclear power plant containments is a topic, which is currently being intensely investigated. With the increase of computer power, it has now become possible to model these phenomena with a local instantaneous description, using so-called Computational Fluid Dynamics (CFD) codes. However, calculations with these codes still take relatively long times. An alternative faster approach, which is also being applied, is to model nonhomogeneous atmosphere with lumped-parameter codes by dividing larger control volumes into smaller volumes, in which conditions are modelled as homogeneous. The flow between smaller volumes is modelled using one-dimensional approaches, which includes the prescription of flow loss coefficients. However, some authors have questioned this approach, as it appears that atmosphere stratification may sometimes be well simulated only by adjusting flow loss coefficients to adequate 'artificial' values that are case-dependent. To start the resolution of this issue, a modelling of nonhomogeneous atmosphere with a lumped-parameter code is proposed, where the subdivision of a large volume into smaller volumes is based on results of CFD simulations. The basic idea is to use the results of a CFD simulation to define regions, in which the flow velocities have roughly the same direction. These regions are then modelled as control volumes in a lumped-parameter model. In the proposed work, this procedure was applied to a simulation of an experiment of atmosphere mixing and stratification, which was performed in the TOSQAN facility. The facility is located at the Institut de Radioprotection et de Surete Nucleaire (IRSN) in Saclay (France) and consists of a cylindrical vessel (volume: 7 m3), in which gases are injected. In the experiment, which was also proposed for the OECD/NEA International Standard Problem No.47, air was initially present in the vessel, and

  2. Chemodynamics of metal ion complexation by charged nanoparticles: a dimensionless rationale for soft, core-shell and hard particle types.

    Science.gov (United States)

    Duval, Jérôme F L

    2017-05-17

    Soft nanoparticulate complexants are defined by a spatial confinement of reactive sites and electric charges inside their 3D body. In turn, their reactivity with metal ions differs significantly from that of simple molecular ligands. A revisited form of the Eigen mechanism recently elucidated the processes leading to metal/soft particle pair formation. Depending on e.g. particle size and metal ion nature, chemodynamics of nanoparticulate metal complexes is controlled by metal conductive diffusion to/from the particles, by intraparticulate complex formation/dissociation kinetics, or by both. In this study, a formalism is elaborated to achieve a comprehensive and systematic identification of the rate-limiting step governing the overall formation and dissociation of nanoparticulate metal complexes. The theory covers the different types of spherical particulate complexants, i.e. 3D soft/permeable and core-shell particles, and hard particles with reactive sites at the surface. The nature of the rate-limiting step is formulated by a dynamical criterion involving a power law function of the ratio between particle radius and an intraparticulate reaction layer thickness defined by the key electrostatic, diffusional and kinetic components of metal complex formation/dissociation. The analysis clarifies the intertwined contributions of particle properties (size, soft or hard type, charge, density or number of reactive sites) and aqueous metal ion dehydration kinetics in defining the chemodynamic behavior of nanoparticulate metal complexes. For that purpose, fully parameterized chemodynamic portraits involving the defining features of particulate ligand and metal ion as well as the physicochemical conditions in the local intraparticulate environment, are constructed and thoroughly discussed under conditions of practical interest.

  3. 14C chronology of the oldest Scandinavian church in use. An AMS/PIXE study of lime lump carbonate in the mortar

    International Nuclear Information System (INIS)

    Lindroos, Alf; Ranta, Heikki; 14C Dating Laboratory, Department of Physics and Astronomy, University of Aarhus (Denmark))" data-affiliation=" (AMS 14C Dating Laboratory, Department of Physics and Astronomy, University of Aarhus (Denmark))" >Heinemeier, Jan; Lill, Jan-Olof

    2014-01-01

    Mortar dating was applied to newly revealed, original mortar in the church of Dalby in Scania, southern Sweden which is considered to be the oldest still standing church in Scandinavia. Small white lime lumps were sampled by chipping from the supporting pillars in the interior of the church. Special emphasis was in sampling lime lumps because the church is situated in the Scania limestone area and aggregate limestone contamination was anticipated in the bulk mortars. Earlier studies have, however, shown that lime lumps do not contain aggregate material but only possible limestone rests from incomplete calcination. The sampled material was prepared for radiocarbon AMS dating. The carbonate in the lime lumps was hydrolyzed according to the sequential leaching technique developed for the Århus 14 C laboratory in Denmark. Prior to the hydrolysis the lime lumps were examined for dead-carbon contamination using a stereo microscope and cathodoluminescence. The lime lumps displayed heterogeneous carbonate luminescence. This is, however, common and it was not considered a problem because carbonate growth in changing pH/Eh conditions often leads to changing luminescence colors. Two lumps had little dead carbon contamination and an early second millennium 14 C signature. One lump, however, seemed to be heavily contaminated with dead carbon. Since the sample passed the microscopic screening, the leftovers of the lump was subjected to PIXE analysis and compared with the other two lumps. The well-defined, early 2nd millennium 14 C age of the lime lumps of this particular church is an important contribution to the discussion on stone church chronology in Scandinavia

  4. {sup 14}C chronology of the oldest Scandinavian church in use. An AMS/PIXE study of lime lump carbonate in the mortar

    Energy Technology Data Exchange (ETDEWEB)

    Lindroos, Alf, E-mail: alf.lindroos@abo.fi [Geology and Mineralogy, Department of Natural Sciences, Åbo Akademi University (Finland); Art History, Faculty of Art, Åbo Akademi University (Finland); Ranta, Heikki [Diocese of Lund, Church of Sweden (Sweden); Heinemeier, Jan [AMS " 1" 4C Dating Laboratory, Department of Physics and Astronomy, University of Aarhus (Denmark); Lill, Jan-Olof [Accelerator Laboratory, Turku PET Centre, Åbo Akademi University (Finland)

    2014-07-15

    Mortar dating was applied to newly revealed, original mortar in the church of Dalby in Scania, southern Sweden which is considered to be the oldest still standing church in Scandinavia. Small white lime lumps were sampled by chipping from the supporting pillars in the interior of the church. Special emphasis was in sampling lime lumps because the church is situated in the Scania limestone area and aggregate limestone contamination was anticipated in the bulk mortars. Earlier studies have, however, shown that lime lumps do not contain aggregate material but only possible limestone rests from incomplete calcination. The sampled material was prepared for radiocarbon AMS dating. The carbonate in the lime lumps was hydrolyzed according to the sequential leaching technique developed for the Århus {sup 14}C laboratory in Denmark. Prior to the hydrolysis the lime lumps were examined for dead-carbon contamination using a stereo microscope and cathodoluminescence. The lime lumps displayed heterogeneous carbonate luminescence. This is, however, common and it was not considered a problem because carbonate growth in changing pH/Eh conditions often leads to changing luminescence colors. Two lumps had little dead carbon contamination and an early second millennium {sup 14}C signature. One lump, however, seemed to be heavily contaminated with dead carbon. Since the sample passed the microscopic screening, the leftovers of the lump was subjected to PIXE analysis and compared with the other two lumps. The well-defined, early 2nd millennium {sup 14}C age of the lime lumps of this particular church is an important contribution to the discussion on stone church chronology in Scandinavia.

  5. Granulated decontamination formulations

    Science.gov (United States)

    Tucker, Mark D.

    2007-10-02

    A decontamination formulation and method of making that neutralizes the adverse health effects of both chemical and biological compounds, especially chemical warfare (CW) and biological warfare (BW) agents, and toxic industrial chemicals. The formulation provides solubilizing compounds that serve to effectively render the chemical and biological compounds, particularly CW and BW compounds, susceptible to attack, and at least one reactive compound that serves to attack (and detoxify or kill) the compound. The formulation includes at least one solubilizing agent, a reactive compound, a sorbent additive, and water. A highly adsorbent sorbent additive (e.g., amorphous silica, sorbitol, mannitol, etc.) is used to "dry out" one or more liquid ingredients into a dry, free-flowing powder that has an extended shelf life, and is more convenient to handle and mix in the field.

  6. The Numerical Welding Simulation - Developments and Validation of Simplified and Bead Lumping Methods

    International Nuclear Information System (INIS)

    Baup, Olivier

    2001-01-01

    The aim of this work was to study the TIG multipass welding process on stainless steel, by means of numerical methods and then to work out simplified and bead lumping methods in order to reduce adjusting and realisation times of these calculations. A simulation was used as reference for the validation of these methods; after the presentation of the test series having led to the option choices of this calculation (2D generalised plane strains, elastoplastic model with an isotropic hardening, hardening restoration due to high temperatures), various simplifications were tried on a plate geometry. These simplifications related various modelling points with a correct plastic flow representation in the plate. The use of a reduced number of thermal fields characterising the bead deposit and a low number of tensile curves allow to obtain interesting results, decreasing significantly the Computing times. In addition various lumping bead methods have been studied and concerning both the shape and the thermic of the macro-deposits. The macro-deposit shapes studied are in 'L', or in layer or they represent two beads one on top of the other. Among these three methods, only those using a few number of lumping beads gave bad results since thermo-mechanical history was deeply modified near and inside the weld. Thereafter, simplified methods have been applied to a tubular geometry. On this new geometry, experimental measurements were made during welding, which allow a validation of the reference calculation. Simplified and reference calculations gave approximately the same stress fields as found on plate geometry. Finally, in the last part of this document a procedure for automatic data setting permitting to reduce significantly the calculation phase preparation is presented. It has been applied to the calculation of thick pipe welding in 90 beads; the results are compared with a simplified simulation realised by Framatome and with experimental measurements. A bead by

  7. General 3D Lumped Thermal Model with Various Boundary Conditions for High Power IGBT Modules

    DEFF Research Database (Denmark)

    Bahman, Amir Sajjad; Ma, Ke; Blaabjerg, Frede

    2016-01-01

    Accurate thermal dynamics modeling of high power Insulated Gate Bipolar Transistor (IGBT) modules is important information for the reliability analysis and thermal design of power electronic systems. However, the existing thermal models have their limits to correctly predict these complicated...... thermal behaviors in the IGBTs. In this paper, a new three-dimensional (3D) lumped thermal model is proposed, which can easily be characterized from Finite Element Methods (FEM) based simulation and acquire the thermal distribution in critical points. Meanwhile the boundary conditions including...... the cooling system and power losses are modeled in the 3D thermal model, which can be adapted to different real field applications of power electronic converters. The accuracy of the proposed thermal model is verified by experimental results....

  8. A passive terahertz video camera based on lumped element kinetic inductance detectors

    International Nuclear Information System (INIS)

    Rowe, Sam; Pascale, Enzo; Doyle, Simon; Dunscombe, Chris; Hargrave, Peter; Papageorgio, Andreas; Ade, Peter A. R.; Barry, Peter; Bideaud, Aurélien; Brien, Tom; Dodd, Chris; House, Julian; Moseley, Paul; Sudiwala, Rashmi; Tucker, Carole; Walker, Ian; Wood, Ken; Grainger, William; Mauskopf, Philip; Spencer, Locke

    2016-01-01

    We have developed a passive 350 GHz (850 μm) video-camera to demonstrate lumped element kinetic inductance detectors (LEKIDs)—designed originally for far-infrared astronomy—as an option for general purpose terrestrial terahertz imaging applications. The camera currently operates at a quasi-video frame rate of 2 Hz with a noise equivalent temperature difference per frame of ∼0.1 K, which is close to the background limit. The 152 element superconducting LEKID array is fabricated from a simple 40 nm aluminum film on a silicon dielectric substrate and is read out through a single microwave feedline with a cryogenic low noise amplifier and room temperature frequency domain multiplexing electronics.

  9. Unusual Presentation of Hydatidosis - Neck Lump Causing Costo-Vertebral Erosion.

    Science.gov (United States)

    Alam, Mehtab; Hasan, Syed-Abrar; Hashmi, Shahab-Farkhund

    2016-09-01

    Hydatid disease caused by larval stage of Echinococcus has been recognized endemically in many countries. Liver and lungs are the most commonly affected organs. Involvement of the head and neck region is rare and bony erosion due to hydatidosis is even rarer. We report a case of a 17-year-old girl from a poor socio-economic background who presented with a right sided supraclavicular lump, which after surgical excision and histopathological examination was diagnosed as hydatid cyst of neck. Because of its rarity in the neck region, primary diagnosis of hydatid cyst is overlooked and usually not included in the differential diagnosis of cystic neck swellings. A high index of suspicion is necessary to diagnose hydatid disease in an unusual location even in endemic areas.

  10. A passive terahertz video camera based on lumped element kinetic inductance detectors

    Energy Technology Data Exchange (ETDEWEB)

    Rowe, Sam, E-mail: sam.rowe@astro.cf.ac.uk; Pascale, Enzo; Doyle, Simon; Dunscombe, Chris; Hargrave, Peter; Papageorgio, Andreas; Ade, Peter A. R.; Barry, Peter; Bideaud, Aurélien; Brien, Tom; Dodd, Chris; House, Julian; Moseley, Paul; Sudiwala, Rashmi; Tucker, Carole; Walker, Ian [Astronomy Instrumentation Group, School of Physics and Astronomy, Cardiff University, Cardiff CF24 3AA (United Kingdom); Wood, Ken [QMC Instruments Ltd., School of Physics and Astronomy, Cardiff University, Cardiff CF24 3AA (United Kingdom); Grainger, William [Rutherford Appleton Laboratory, STFC, Swindon SN2 1SZ (United Kingdom); Mauskopf, Philip [Astronomy Instrumentation Group, School of Physics and Astronomy, Cardiff University, Cardiff CF24 3AA (United Kingdom); School of Earth Science and Space Exploration, Arizona State University, Tempe, Arizona 85281 (United States); Spencer, Locke [Department of Physics and Astronomy, University of Lethbridge, Lethbridge, Alberta T1K 3M4 (Canada)

    2016-03-15

    We have developed a passive 350 GHz (850 μm) video-camera to demonstrate lumped element kinetic inductance detectors (LEKIDs)—designed originally for far-infrared astronomy—as an option for general purpose terrestrial terahertz imaging applications. The camera currently operates at a quasi-video frame rate of 2 Hz with a noise equivalent temperature difference per frame of ∼0.1 K, which is close to the background limit. The 152 element superconducting LEKID array is fabricated from a simple 40 nm aluminum film on a silicon dielectric substrate and is read out through a single microwave feedline with a cryogenic low noise amplifier and room temperature frequency domain multiplexing electronics.

  11. The application of model with lumped parameters for transient condition analyses of NPP

    International Nuclear Information System (INIS)

    Stankovic, B.; Stevanovic, V.

    1985-01-01

    The transient behaviour of NPP Krsko during the accident of pressurizer spray valve stuck open has been simulated y lumped parameters model of the PWR coolant system components, developed at the faculty of Mechanical Engineering, University of Belgrade. The elementary volumes which are characterised by the process and state parameters, and by junctions which are characterised by the geometrical and flow parameters are basic structure of physical model. The process parameters obtained by the model RESI, show qualitative agreement with the measured valves, in a degree in which the actions of reactor safety engineered system and emergency core cooling system are adequately modelled; in spite of the elementary physical model structure and only the modelling of thermal process in reactor core and equilibrium conditions of pressurizer and steam generator. The pressurizer pressure and liquid level predicted by the non-equilibrium pressurizer model SOP show good agreement until the HIPS (high pressure pumps) is activated. (author)

  12. Computing Fault-Containment Times of Self-Stabilizing Algorithms Using Lumped Markov Chains

    Directory of Open Access Journals (Sweden)

    Volker Turau

    2018-05-01

    Full Text Available The analysis of self-stabilizing algorithms is often limited to the worst case stabilization time starting from an arbitrary state, i.e., a state resulting from a sequence of faults. Considering the fact that these algorithms are intended to provide fault tolerance in the long run, this is not the most relevant metric. A common situation is that a running system is an a legitimate state when hit by a single fault. This event has a much higher probability than multiple concurrent faults. Therefore, the worst case time to recover from a single fault is more relevant than the recovery time from a large number of faults. This paper presents techniques to derive upper bounds for the mean time to recover from a single fault for self-stabilizing algorithms based on Markov chains in combination with lumping. To illustrate the applicability of the techniques they are applied to a new self-stabilizing coloring algorithm.

  13. A new lumped-parameter approach to simulating flow processes in unsaturated dual-porosity media

    Energy Technology Data Exchange (ETDEWEB)

    Zimmerman, R.W.; Hadgu, T.; Bodvarsson, G.S. [Lawrence Berkeley Laboratory, CA (United States)

    1995-03-01

    We have developed a new lumped-parameter dual-porosity approach to simulating unsaturated flow processes in fractured rocks. Fluid flow between the fracture network and the matrix blocks is described by a nonlinear equation that relates the imbibition rate to the local difference in liquid-phase pressure between the fractures and the matrix blocks. This equation is a generalization of the Warren-Root equation, but unlike the Warren-Root equation, is accurate in both the early and late time regimes. The fracture/matrix interflow equation has been incorporated into a computational module, compatible with the TOUGH simulator, to serve as a source/sink term for fracture elements. The new approach achieves accuracy comparable to simulations in which the matrix blocks are discretized, but typically requires an order of magnitude less computational time.

  14. Lumped Parameter Models of the Central Nervous System for VIIP Research

    Science.gov (United States)

    Vera, J.; Mulugeta, L.; Nelson, E. S.; Raykin, J.; Feola, A.; Gleason, R.; Samuels, B.; Myers, J. G.

    2015-01-01

    INTRODUCTION: Current long-duration missions to the International Space Station and future exploration-class missions beyond low-Earth orbit, such as to Mars and asteroids, expose astronauts to increased risk of Visual Impairment and Intracranial Pressure (VIIP) syndrome [1]. It has been hypothesized that the headward shift of cerebral spinal fluid (CSF) and blood in microgravity may cause significant elevation of intracranial pressure (ICP), which in turn induces VIIP syndrome through biomechanical pathways [1, 2]. However, there is insufficient evidence to confirm this hypothesis. In this light, we are developing lumped-parameter models of fluid transport in the central nervous system (CNS) as a means to simulate the influence of microgravity on ICP. The CNS models will also be used in concert with the lumped parameter and finite element models of the eye described in the realted IWS abstracts submitted by Nelson et al., Feola et al. and Ethier et al. METHODS: We have developed a nine compartment CNS model (Figure 1) capable of both time-dependent and steady state fluid transport simulations, based on the works of Stevens et al. [3]. The breakdown of compartments within the model includes: vascular (3), CSF (2), brain (1) and extracranial (3). The boundary pressure in the Central Arteries [A] node is prescribed using an oscillating pressure function PA(t) simulating the carotid pulsatile pressure wave as developed by Linninger et al. [4]. For each time step, pressures are integrated through time using an adaptive-timestep 4th and 5th order Runga-Kutta solver. Once pressures are found, constitutive equations are used to solve for flowrates (Q) between each compartment. In addition to fluid flow between the different compartments, compliance (C) interactions between neighboring compartments are represented. We are also developing a second CNS model based on the works of Linninger et al. [4] which takes a more granular approach to represent the interactions of the

  15. Mammographic and sonographic findings of steatocystoma multiplex presenting as breast lumps.

    Science.gov (United States)

    Wan, John Mun Chin; Wong, Jill Su Lin; Tee, Shang-Ian

    2012-12-01

    Steatocystoma multiplex (SM) is an uncommon cutaneous disorder characterised by multiple intradermal cysts distributed over the trunk and proximal extremities. This condition affects both genders and is often inherited as an autosomal dominant trait, although sporadic cases have been described. This report describes the mammographic and sonographic features of the cysts, which presented as breast lumps, for evaluation. The cysts appeared as numerous well-circumscribed, radiolucent nodules with thin radiodense rims on mammography. On sonography, the cysts could be hypoechoic, isoechoic or demonstrate mixed echoes containing debris-fluid levels, depending on the amount of clear oily liquid and keratinous material. SM can be diagnosed based on a clinical setting of multiple asymptomatic small intradermal nodules over the trunk and proximal extremities, positive family history and imaging findings.

  16. The welfare gain from replacing the health insurance tax exclusion with lump-sum tax credits.

    Science.gov (United States)

    Liu, Liqun; Rettenmaier, Andrew J; Saving, Thomas R

    2011-06-01

    This paper analyzes the welfare gain from replacing the tax exclusion of employer-provided health insurance with a lump-sum tax credit. It differs from earlier studies in that we look at the welfare cost of health insurance tax exclusion as coming directly from excessive health insurance rather than from overconsumption of medical care and that we account for the labor market effect of the tax exclusion on welfare. Both differences work to produce a smaller tax reform welfare gain. For a set of mid-range parameter values, the welfare gain is about 21% of current health insurance tax expenditures. In addition, government tax expenditures would fall by 38%, and health insurance spending would fall by 77% after the reform.

  17. Collective strong coupling with homogeneous Rabi frequencies using a 3D lumped element microwave resonator

    International Nuclear Information System (INIS)

    Angerer, Andreas; Astner, Thomas; Wirtitsch, Daniel; Majer, Johannes; Sumiya, Hitoshi; Onoda, Shinobu; Isoya, Junichi; Putz, Stefan

    2016-01-01

    We design and implement 3D-lumped element microwave cavities that spatially focus magnetic fields to a small mode volume. They allow coherent and uniform coupling to electron spins hosted by nitrogen vacancy centers in diamond. We achieve large homogeneous single spin coupling rates, with an enhancement of more than one order of magnitude compared to standard 3D cavities with a fundamental resonance at 3 GHz. Finite element simulations confirm that the magnetic field distribution is homogeneous throughout the entire sample volume, with a root mean square deviation of 1.54%. With a sample containing 10"1"7 nitrogen vacancy electron spins, we achieve a collective coupling strength of Ω = 12 MHz, a cooperativity factor C = 27, and clearly enter the strong coupling regime. This allows to interface a macroscopic spin ensemble with microwave circuits, and the homogeneous Rabi frequency paves the way to manipulate the full ensemble population in a coherent way.

  18. Scattering of massless lumps and non-local charges in the two-dimensional classical non-linear sigma-model

    International Nuclear Information System (INIS)

    Luescher, M.; Pohlmeyer, K.

    1977-09-01

    Finite energy solutions of the field equations of the non-linear sigma-model are shown to decay asymptotically into massless lumps. By means of a linear eigenvalue problem connected with the field equations we then find an infinite set of dynamical conserved charges. They, however, do not provide sufficient information to decode the complicated scattering of lumps. (orig.) [de

  19. Comment on "Beyond the SCS-CN method: A theoretical framework for spatially lumped rainfall-runoff response" by M. S. Bartlett et al.

    Science.gov (United States)

    Ogden, Fred L.; Hawkins, Richard Pete; Walter, M. Todd; Goodrich, David C.

    2017-07-01

    Bartlett et al. (2016) performed a re-interpretation and modification of the space-time lumped USDA NRCS (formerly SCS) Curve Number (CN) method to extend its applicability to forested watersheds. We believe that the well documented limitations of the CN method severely constrains the applicability of the modifications proposed by Bartlett et al. (2016). This forward-looking comment urges the research communities in hydrologic science and engineering to consider the CN method as a stepping stone that has outlived its usefulness in research. The CN method fills a narrow niche in certain settings as a parsimonious method having utility as an empirical equation to estimate runoff from a given amount of rainfall, which originated as a static functional form that fits rainfall-runoff data sets. Sixty five years of use and multiple reinterpretations have not resulted in improved hydrological predictability using the method. We suggest that the research community should move forward by (1) identifying appropriate dynamic hydrological model formulations for different hydro-geographic settings, (2) specifying needed model capabilities for solving different classes of problems (e.g., flooding, erosion/sedimentation, nutrient transport, water management, etc.) in different hydro-geographic settings, and (3) expanding data collection and research programs to help ameliorate the so-called "overparameterization" problem in contemporary modeling. Many decades of advances in geo-spatial data and processing, computation, and understanding are being squandered on continued focus on the static CN regression method. It is time to truly "move beyond" the Curve Number method.

  20. INCIDENCE OF BENIGN BREAST LUMP ABOVE 40 YRS. OF AGE IN FEMALE ATTENDING MGMGH, TIRUCHIRAPPALLI

    Directory of Open Access Journals (Sweden)

    Ayyaswamy Thulasi

    2016-10-01

    Full Text Available BACKGROUND AND OBJECTIVES The breast is the essential symbol of womanhood to society and to the woman herself. Subjected every month to the onslaught of ovarian, adrenal, pituitary and thyroid hormones in tandem with the uterus, the very histological architecture of the breast changes sequentially. With the recent importance given to early diagnosis of cancer of the breast and its early detection by both the patient and her physician, more benign conditions are likely to be detected than earlier. The objective of our review is to find out the incidence of benign breast lump above 40 years of age in females attending our hospital. METHODS AND MATERIALS 130 patients presenting to the outpatient department of KAPV Medical College with breast lump were included in this comprehensive study. A detailed history regarding the duration and nature of the complaints, family history pertaining to breast or ovarian cancers, risk factors such as oral contraceptive use, parity, lactation, etc. was elicited. A thorough clinical examination was performed. RESULTS Of 24 cases of fibroadenoma, all were operated upon by excision. Of 38 patients with fibroadenosis, 30 patients managed conservatively and surgery for 8 patients where the diagnosis was doubtful. Abscesses were incised and drained under antibiotic cover for 3 patients. 8 cases of breast cyst were managed by aspiration. TB mastitis was confirmed by excisional biopsy and followed up by antituberculous therapy with regular follow up after 6 months. Healed lesions were found to be associated with improved general condition of the patients. Lipoma and sebaceous cyst were managed by excision biopsy. CONCLUSION Benign breast diseases were found to be common in woman above 40 years old in contrast to normal teaching, which says they are common in younger age groups. Fibroadenosis was the commonest benign disease closely followed by fibroadenoma. Fibroadenosis was mostly managed conservatively. Excision biopsy

  1. Deducing Electronic Unit Internal Response During a Vibration Test Using a Lumped Parameter Modeling Approach

    Science.gov (United States)

    Van Dyke, Michael B.

    2014-01-01

    During random vibration testing of electronic boxes there is often a desire to know the dynamic response of certain internal printed wiring boards (PWBs) for the purpose of monitoring the response of sensitive hardware or for post-test forensic analysis in support of anomaly investigation. Due to restrictions on internally mounted accelerometers for most flight hardware there is usually no means to empirically observe the internal dynamics of the unit, so one must resort to crude and highly uncertain approximations. One common practice is to apply Miles Equation, which does not account for the coupled response of the board in the chassis, resulting in significant over- or under-prediction. This paper explores the application of simple multiple-degree-of-freedom lumped parameter modeling to predict the coupled random vibration response of the PWBs in their fundamental modes of vibration. A simple tool using this approach could be used during or following a random vibration test to interpret vibration test data from a single external chassis measurement to deduce internal board dynamics by means of a rapid correlation analysis. Such a tool might also be useful in early design stages as a supplemental analysis to a more detailed finite element analysis to quickly prototype and analyze the dynamics of various design iterations. After developing the theoretical basis, a lumped parameter modeling approach is applied to an electronic unit for which both external and internal test vibration response measurements are available for direct comparison. Reasonable correlation of the results demonstrates the potential viability of such an approach. Further development of the preliminary approach presented in this paper will involve correlation with detailed finite element models and additional relevant test data.

  2. Beyond the SCS-CN method: A theoretical framework for spatially lumped rainfall-runoff response

    Science.gov (United States)

    Bartlett, M. S.; Parolari, A. J.; McDonnell, J. J.; Porporato, A.

    2016-06-01

    Since its introduction in 1954, the Soil Conservation Service curve number (SCS-CN) method has become the standard tool, in practice, for estimating an event-based rainfall-runoff response. However, because of its empirical origins, the SCS-CN method is restricted to certain geographic regions and land use types. Moreover, it does not describe the spatial variability of runoff. To move beyond these limitations, we present a new theoretical framework for spatially lumped, event-based rainfall-runoff modeling. In this framework, we describe the spatially lumped runoff model as a point description of runoff that is upscaled to a watershed area based on probability distributions that are representative of watershed heterogeneities. The framework accommodates different runoff concepts and distributions of heterogeneities, and in doing so, it provides an implicit spatial description of runoff variability. Heterogeneity in storage capacity and soil moisture are the basis for upscaling a point runoff response and linking ecohydrological processes to runoff modeling. For the framework, we consider two different runoff responses for fractions of the watershed area: "prethreshold" and "threshold-excess" runoff. These occur before and after infiltration exceeds a storage capacity threshold. Our application of the framework results in a new model (called SCS-CNx) that extends the SCS-CN method with the prethreshold and threshold-excess runoff mechanisms and an implicit spatial description of runoff. We show proof of concept in four forested watersheds and further that the resulting model may better represent geographic regions and site types that previously have been beyond the scope of the traditional SCS-CN method.

  3. Patient-specific parameter estimation in single-ventricle lumped circulation models under uncertainty

    Science.gov (United States)

    Schiavazzi, Daniele E.; Baretta, Alessia; Pennati, Giancarlo; Hsia, Tain-Yen; Marsden, Alison L.

    2017-01-01

    Summary Computational models of cardiovascular physiology can inform clinical decision-making, providing a physically consistent framework to assess vascular pressures and flow distributions, and aiding in treatment planning. In particular, lumped parameter network (LPN) models that make an analogy to electrical circuits offer a fast and surprisingly realistic method to reproduce the circulatory physiology. The complexity of LPN models can vary significantly to account, for example, for cardiac and valve function, respiration, autoregulation, and time-dependent hemodynamics. More complex models provide insight into detailed physiological mechanisms, but their utility is maximized if one can quickly identify patient specific parameters. The clinical utility of LPN models with many parameters will be greatly enhanced by automated parameter identification, particularly if parameter tuning can match non-invasively obtained clinical data. We present a framework for automated tuning of 0D lumped model parameters to match clinical data. We demonstrate the utility of this framework through application to single ventricle pediatric patients with Norwood physiology. Through a combination of local identifiability, Bayesian estimation and maximum a posteriori simplex optimization, we show the ability to automatically determine physiologically consistent point estimates of the parameters and to quantify uncertainty induced by errors and assumptions in the collected clinical data. We show that multi-level estimation, that is, updating the parameter prior information through sub-model analysis, can lead to a significant reduction in the parameter marginal posterior variance. We first consider virtual patient conditions, with clinical targets generated through model solutions, and second application to a cohort of four single-ventricle patients with Norwood physiology. PMID:27155892

  4. Lumped-Element Dynamic Electro-Thermal model of a superconducting magnet

    Science.gov (United States)

    Ravaioli, E.; Auchmann, B.; Maciejewski, M.; ten Kate, H. H. J.; Verweij, A. P.

    2016-12-01

    Modeling accurately electro-thermal transients occurring in a superconducting magnet is challenging. The behavior of the magnet is the result of complex phenomena occurring in distinct physical domains (electrical, magnetic and thermal) at very different spatial and time scales. Combined multi-domain effects significantly affect the dynamic behavior of the system and are to be taken into account in a coherent and consistent model. A new methodology for developing a Lumped-Element Dynamic Electro-Thermal (LEDET) model of a superconducting magnet is presented. This model includes non-linear dynamic effects such as the dependence of the magnet's differential self-inductance on the presence of inter-filament and inter-strand coupling currents in the conductor. These effects are usually not taken into account because superconducting magnets are primarily operated in stationary conditions. However, they often have significant impact on magnet performance, particularly when the magnet is subject to high ramp rates. Following the LEDET method, the complex interdependence between the electro-magnetic and thermal domains can be modeled with three sub-networks of lumped-elements, reproducing the electrical transient in the main magnet circuit, the thermal transient in the coil cross-section, and the electro-magnetic transient of the inter-filament and inter-strand coupling currents in the superconductor. The same simulation environment can simultaneously model macroscopic electrical transients and phenomena at the level of superconducting strands. The model developed is a very useful tool for reproducing and predicting the performance of conventional quench protection systems based on energy extraction and quench heaters, and of the innovative CLIQ protection system as well.

  5. Lumped versus distributed thermoregulatory control: results from a three-dimensional dynamic model.

    Science.gov (United States)

    Werner, J; Buse, M; Foegen, A

    1989-01-01

    In this study we use a three-dimensional model of the human thermal system, the spatial grid of which is 0.5 ... 1.0 cm. The model is based on well-known physical heat-transfer equations, and all parameters of the passive system have definite physical values. According to the number of substantially different areas and organs, 54 spatially different values are attributed to each physical parameter. Compatibility of simulation and experiment was achieved solely on the basis of physical considerations and physiological basic data. The equations were solved using a modification of the alternating direction implicit method. On the basis of this complex description of the passive system close to reality, various lumped and distributed parameter control equations were tested for control of metabolic heat production, blood flow and sweat production. The simplest control equations delivering results on closed-loop control compatible with experimental evidence were determined. It was concluded that it is essential to take into account the spatial distribution of heat production, blood flow and sweat production, and that at least for control of shivering, distributed controller gains different from the pattern of distribution of muscle tissue are required. For sweat production this is not so obvious, so that for simulation of sweating control after homogeneous heat load a lumped parameter control may be justified. Based on these conclusions three-dimensional temperature profiles for cold and heat load and the dynamics for changes of the environmental conditions were computed. In view of the exact simulation of the passive system and the compatibility with experimentally attainable variables there is good evidence that those values extrapolated by the simulation are adequately determined. The model may be used both for further analysis of the real thermoregulatory mechanisms and for special applications in environmental and clinical health care.

  6. Rogue waves and lump solutions for a (3+1)-dimensional generalized B-type Kadomtsev-Petviashvili equation in fluid mechanics

    Science.gov (United States)

    Wu, Xiao-Yu; Tian, Bo; Chai, Han-Peng; Sun, Yan

    2017-08-01

    Under investigation in this letter is a (3+1)-dimensional generalized B-type Kadomtsev-Petviashvili equation, which describes the weakly dispersive waves propagating in a fluid. Employing the Hirota method and symbolic computation, we obtain the lump, breather-wave and rogue-wave solutions under certain constraints. We graphically study the lump waves with the influence of the parameters h1, h3 and h5 which are all the real constants: When h1 increases, amplitude of the lump wave increases, and location of the peak moves; when h3 increases, lump wave’s amplitude decreases, but location of the peak keeps unchanged; when h5 changes, lump wave’s peak location moves, but amplitude keeps unchanged. Breather waves and rogue waves are displayed: Rogue waves emerge when the periods of the breather waves go to the infinity.

  7. Effects of non-LTE multiplet dynamics on lumped-state modelling in moderate to high atomic number plasmas

    International Nuclear Information System (INIS)

    Whitney, K G; Dasgupta, A; Davis, J; Coverdale, C A

    2007-01-01

    Two atomic models of the population dynamics of substates within the n 4 and n = 3 multiplets of nickel-like tungsten and beryllium-like iron, respectively, are described in this paper. The flexible atomic code (FAC) is used to calculate the collisional and radiative couplings and energy levels of the excited states within these ionization stages. These atomic models are then placed within larger principal-quantum-number-based ionization dynamic models of both tungsten and iron plasmas. Collisional-radiative equilibrium calculations are then carried out using these models that demonstrate how the multiplet substates depart from local thermodynamic equilibrium (LTE) as a function of ion density. The effect of these deviations from LTE on the radiative and collisional deexcitation rates of lumped 3s, 3p, 3d, 4s, 4p, 4d and 4f states is then calculated and least-squares fits to the density dependence of these lumped-state rate coefficients are obtained. The calculations show that, with the use of lumped-state models (which are in common use), one can accurately model the L- and M-shell ionization dynamics occurring in present-day Z-pinch experiments only through the addition of these extra, non-LTE-induced, rate coefficient density dependences. However, the derivation and use of low-order polynomial fits to these density dependences makes lumped-state modelling both viable and of value for post-processing analyses

  8. Dynamic analysis of the 7-GeV APS experiment hall foundation based on equivalent lumped parameter modeling

    International Nuclear Information System (INIS)

    Wambsganss, M.W.

    1989-01-01

    In this technical note, mass-spring-dashpot, also referred to as equivalent lumped parameter, models are employed to model the soil-foundation interaction of two typical floor segments from the 7-GeV APS experiment hall. Equivalent lumped parameter models have the advantage of being easy to apply and of readily allowing for parameter studies. Analysis requires knowledge of certain properties of the soil including density, shear wave velocity, and Poisson's ratio, as well as knowledge of the degree of homogeneity of the underlying soil stratum. These data for the APS site were determined by a geotechnical investigation. A soil profile and pertinent data, obtained from crosshole seismic testing, are given. Natural frequencies and damping are calculated for the vertical, sliding, rocking, and coupled rocking/sliding modes of vibration. Subsequently, various corrections to account for modeling ''deficiencies'' are considered and their influences evaluated. The equivalent lumped parameter models were developed for machine foundations which, compared with the APS foundation, are smaller in plan dimension. Therefore, the applicability of these models in the analysis of the dynamic characteristics of the APS foundation must be established. The modeling is evaluated by applying the equivalent lumped parameter models in the analysis of large foundations for which test data exists. A comparison of theoretical and test results establishes the basis for an assessment of the applicability and accuracy of the modeling

  9. Analysis of stability and bifurcations of fixed points and periodic solutions of a lumped model of neocortex with two delays

    NARCIS (Netherlands)

    Visser, Sid; Meijer, Hil G.E.; van Putten, Michel J.A.M.; van Gils, Stephan A.

    2012-01-01

    A lumped model of neural activity in neocortex is studied to identify regions of multi-stability of both steady states and periodic solutions. Presence of both steady states and periodic solutions is considered to correspond with epileptogenesis. The model, which consists of two delay differential

  10. Comparative study of aspiration and non-aspiration cytology of palpable breast lumps and correlation with histopathology

    Directory of Open Access Journals (Sweden)

    S Koirala

    2014-09-01

    Full Text Available Background: Breast lump is one of the most common presentations in surgical outpatient departments with anxiety regarding a possible malignancy. Hence a quick diagnosis of a lump in the breast is essential. Fine needle aspiration cytology is an ideal initial diagnostic modality in breast lumps. There is an alternative method of performing needle aspiration, known as fine needle capillary cytology where the specimen is obtained using just a needle without aspiration.Materials and Methods: This hospital-based cross sectional analytical study was carried out in Department of Pathology in National Academy of Medical Sciences, Bir Hospital for one year. The objective of this study was to compare aspiration and non-aspiration cytology of palpable breast lumps and correlation with histopathology.Results: The five criteria scored for each technique were background blood, amount of cellular material, cellular degeneration, cellular trauma and architectural preservation. Compared to fine needle aspiration cytology, fine needle capillary cytology yields less bloody smears with minimal degenerative changes and offers more diagnostically superior specimens. Fine needle aspiration cytology, on the other hand, gives a good yield of diagnostic material.Conclusion: Fine needle aspiration cytology and fine needle capillary cytology are quick, easy, safe and cost-effective techniques. . A high sensitivity and specificity of cytological diagnosis in this study proves that it is comparable to final histology report in its diagnostic efficiency. Thus, fine needle aspiration cytology is a very important preliminary diagnostic test in palpable breast lumps and the results show a high degree of correlation with the final histopathology report.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11501 Journal of Pathology of Nepal; Vol.4,No. 8 (2014 639-643

  11. Dynamics of lumps and dark-dark solitons in the multi-component long-wave-short-wave resonance interaction system

    Science.gov (United States)

    Rao, Jiguang; Porsezian, Kuppuswamy; He, Jingsong; Kanna, Thambithurai

    2018-01-01

    General semi-rational solutions of an integrable multi-component (2+1)-dimensional long-wave-short-wave resonance interaction system comprising multiple short waves and a single long wave are obtained by employing the bilinear method. These solutions describe the interactions between various types of solutions, including line rogue waves, lumps, breathers and dark solitons. We only focus on the dynamical behaviours of the interactions between lumps and dark solitons in this paper. Our detailed study reveals two different types of excitation phenomena: fusion and fission. It is shown that the fundamental (simplest) semi-rational solutions can exhibit fission of a dark soliton into a lump and a dark soliton or fusion of one lump and one dark soliton into a dark soliton. The non-fundamental semi-rational solutions are further classified into three subclasses: higher-order, multi- and mixed-type semi-rational solutions. The higher-order semi-rational solutions show the process of annihilation (production) of two or more lumps into (from) one dark soliton. The multi-semi-rational solutions describe N(N≥2) lumps annihilating into or producing from N-dark solitons. The mixed-type semi-rational solutions are a hybrid of higher-order semi-rational solutions and multi-semi-rational solutions. For the mixed-type semi-rational solutions, we demonstrate an interesting dynamical behaviour that is characterized by partial suppression or creation of lumps from the dark solitons.

  12. Dynamics of lumps and dark-dark solitons in the multi-component long-wave-short-wave resonance interaction system.

    Science.gov (United States)

    Rao, Jiguang; Porsezian, Kuppuswamy; He, Jingsong; Kanna, Thambithurai

    2018-01-01

    General semi-rational solutions of an integrable multi-component (2+1)-dimensional long-wave-short-wave resonance interaction system comprising multiple short waves and a single long wave are obtained by employing the bilinear method. These solutions describe the interactions between various types of solutions, including line rogue waves, lumps, breathers and dark solitons. We only focus on the dynamical behaviours of the interactions between lumps and dark solitons in this paper. Our detailed study reveals two different types of excitation phenomena: fusion and fission. It is shown that the fundamental (simplest) semi-rational solutions can exhibit fission of a dark soliton into a lump and a dark soliton or fusion of one lump and one dark soliton into a dark soliton. The non-fundamental semi-rational solutions are further classified into three subclasses: higher-order, multi- and mixed-type semi-rational solutions. The higher-order semi-rational solutions show the process of annihilation (production) of two or more lumps into (from) one dark soliton. The multi-semi-rational solutions describe N ( N ≥2) lumps annihilating into or producing from N -dark solitons. The mixed-type semi-rational solutions are a hybrid of higher-order semi-rational solutions and multi-semi-rational solutions. For the mixed-type semi-rational solutions, we demonstrate an interesting dynamical behaviour that is characterized by partial suppression or creation of lumps from the dark solitons.

  13. Influences of lumped passes on welding residual stress of a thick-walled nuclear rotor steel pipe by multipass narrow gap welding

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Long, E-mail: mse.longtan@gmail.com [State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an 710049 (China); Zhang, Jianxun; Zhuang, Dong [State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an 710049 (China); Liu, Chuan [Provincial Key Lab of Advanced Welding Technology, Jiangsu University of Science and Technology, Zhenjiang 212003 (China)

    2014-07-01

    Highlights: • The internal residual stress of the thick-walled pipe is measured by using the local removal blind hole method. • Two lumped-pass models are developed to reduce computational cost. • The effect of lumped passes on the welding residual stress is discussed. • Reasonable lumped-pass model can guarantee the accuracy and improve the computational efficiency. - Abstract: The purpose of this study is to investigate the effect of the lumped passes simulation on the distribution of residual stresses before and after heat treatment in a thick-walled nuclear power rotor pipe with a 89-pass narrow gap welding process. The local removal blind hole method was used to measure internal residual stress of the thick-walled pipe after post weld heat treatment (PWHT). Based on the ANSYS software, a two-dimensional axisymmetric finite element model is employed. Two lumped-pass models of M-5th model (five weld beads as one lumped pass) and M-10th model (ten weld beads as one lumped pass) were developed to reduce computational cost. Based on the results in this study, the distributions of residual stresses of a thick-walled welded pipe before and after PWHT are developed. Meanwhile, the distribution of the through-wall axial residual stress along the weld center line is demonstrated to be a self-equilibrating type. In addition, the investigation results show that reasonable and reliable lumped-pass model can not only guarantee the accuracy of the simulated results, but also improve the computational efficiency in the thermo-elastic–plastic FE analysis procedure. Therefore, from the viewpoint of engineering application the developed lumped-pass computational procedure is a promising and useful method to predict residual stress of large and complex welded structures.

  14. Influences of lumped passes on welding residual stress of a thick-walled nuclear rotor steel pipe by multipass narrow gap welding

    International Nuclear Information System (INIS)

    Tan, Long; Zhang, Jianxun; Zhuang, Dong; Liu, Chuan

    2014-01-01

    Highlights: • The internal residual stress of the thick-walled pipe is measured by using the local removal blind hole method. • Two lumped-pass models are developed to reduce computational cost. • The effect of lumped passes on the welding residual stress is discussed. • Reasonable lumped-pass model can guarantee the accuracy and improve the computational efficiency. - Abstract: The purpose of this study is to investigate the effect of the lumped passes simulation on the distribution of residual stresses before and after heat treatment in a thick-walled nuclear power rotor pipe with a 89-pass narrow gap welding process. The local removal blind hole method was used to measure internal residual stress of the thick-walled pipe after post weld heat treatment (PWHT). Based on the ANSYS software, a two-dimensional axisymmetric finite element model is employed. Two lumped-pass models of M-5th model (five weld beads as one lumped pass) and M-10th model (ten weld beads as one lumped pass) were developed to reduce computational cost. Based on the results in this study, the distributions of residual stresses of a thick-walled welded pipe before and after PWHT are developed. Meanwhile, the distribution of the through-wall axial residual stress along the weld center line is demonstrated to be a self-equilibrating type. In addition, the investigation results show that reasonable and reliable lumped-pass model can not only guarantee the accuracy of the simulated results, but also improve the computational efficiency in the thermo-elastic–plastic FE analysis procedure. Therefore, from the viewpoint of engineering application the developed lumped-pass computational procedure is a promising and useful method to predict residual stress of large and complex welded structures

  15. Systematic Equation Formulation

    DEFF Research Database (Denmark)

    Lindberg, Erik

    2007-01-01

    A tutorial giving a very simple introduction to the set-up of the equations used as a model for an electrical/electronic circuit. The aim is to find a method which is as simple and general as possible with respect to implementation in a computer program. The “Modified Nodal Approach”, MNA, and th......, and the “Controlled Source Approach”, CSA, for systematic equation formulation are investigated. It is suggested that the kernel of the P Spice program based on MNA is reprogrammed....

  16. Drug delivery and formulations.

    Science.gov (United States)

    Breitkreutz, Jörg; Boos, Joachim

    2011-01-01

    Paediatric drug delivery is a major challenge in drug development. Because of the heterogeneous nature of the patient group, ranging from newborns to adolescents, there is a need to use appropriate excipients, drug dosage forms and delivery devices for different age groups. So far, there is a lack of suitable and safe drug formulations for children, especially for the very young and seriously ill patients. The new EU legislation will enforce paediatric clinical trials and drug development. Current advances in paediatric drug delivery include interesting new concepts such as fast-dissolving drug formulations, including orodispersible tablets and oral thin strips (buccal wafers), and multiparticulate dosage forms based on mini-tabletting or pelletization technologies. Parenteral administration is likely to remain the first choice for children in the neonatal period and for emergency cases. Alternative routes of administration include transdermal, pulmonary and nasal drug delivery systems. A few products are already available on the market, but others still need further investigations and clinical proof of concept.

  17. Ether formulations of relativity

    International Nuclear Information System (INIS)

    Duffy, M.C.

    1980-01-01

    Contemporary ether theories are surveyed and criticised, especially those formally identical to orthodox Relativity. The historical development of Relativity, Special and General, in terms of an ether, is briefly indicated. Classical interpretations of Generalized Relativity using ether are compared to Euclidean formulations using a background space. The history of a sub-group of theories, formulating a 'new' Relativity involving modified transforms, is outlined. According to the theory with which they agree, recent supposed detections of drift are classified and criticised. Cosmological evidence suggesting an ether is mentioned. Only ether theories formally identical to Relativity have been published in depth. They stand criticised as being contrary to the positivist spirit. The history of mechanical analogues is traced, from Hartley's representing gravitating matter as spherical standing waves, to recent suggestions that vortex-sponge might model electromagnetic, quantum, uncertainty and faster-than-light phenomena. Contemporary theories are particular physical theories, themselves 'second interpretations' of a primary mathematical model. Mechanical analogues are auxiliary, not necessary, to other theory, disclosing relationships between classical and non-classical descriptions of assemblies charging state. The ether-relativity polemic, part of a broader dispute about relativity, is founded on mistaken conceptions of the roles of mathematical and physical models, mechanical analogues; and a distored view of history, which indicates that ether theories have become relativistic. (author)

  18. Development of CAP code for nuclear power plant containment: Lumped model

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Soon Joon, E-mail: sjhong90@fnctech.com [FNC Tech. Co. Ltd., Heungdeok 1 ro 13, Giheung-gu, Yongin-si, Gyeonggi-do 446-908 (Korea, Republic of); Choo, Yeon Joon; Hwang, Su Hyun; Lee, Byung Chul [FNC Tech. Co. Ltd., Heungdeok 1 ro 13, Giheung-gu, Yongin-si, Gyeonggi-do 446-908 (Korea, Republic of); Ha, Sang Jun [Central Research Institute, Korea Hydro & Nuclear Power Company, Ltd., 70, 1312-gil, Yuseong-daero, Yuseong-gu, Daejeon 305-343 (Korea, Republic of)

    2015-09-15

    Highlights: • State-of-art containment analysis code, CAP, has been developed. • CAP uses 3-field equations, water level oriented upwind scheme, local head model. • CAP has a function of linked calculation with reactor coolant system code. • CAP code assessments showed appropriate prediction capabilities. - Abstract: CAP (nuclear Containment Analysis Package) code has been developed in Korean nuclear society for the analysis of nuclear containment thermal hydraulic behaviors including pressure and temperature trends and hydrogen concentration. Lumped model of CAP code uses 2-phase, 3-field equations for fluid behaviors, and has appropriate constitutive equations, 1-dimensional heat conductor model, component models, trip and control models, and special process models. CAP can run in a standalone mode or a linked mode with a reactor coolant system analysis code. The linked mode enables the more realistic calculation of a containment response and is expected to be applicable to a more complicated advanced plant design calculation. CAP code assessments were carried out by gradual approaches: conceptual problems, fundamental phenomena, component and principal phenomena, experimental validation, and finally comparison with other code calculations on the base of important phenomena identifications. The assessments showed appropriate prediction capabilities of CAP.

  19. Impact of atrial fibrillation on the cardiovascular system through a lumped-parameter approach.

    Science.gov (United States)

    Scarsoglio, Stefania; Guala, Andrea; Camporeale, Carlo; Ridolfi, Luca

    2014-11-01

    Atrial fibrillation (AF) is the most common arrhythmia affecting millions of people in the Western countries and, due to the widespread impact on the population and its medical relevance, is largely investigated in both clinical and bioengineering sciences. However, some important feedback mechanisms are still not clearly established. The present study aims at understanding the global response of the cardiovascular system during paroxysmal AF through a lumped-parameter approach, which is here performed paying particular attention to the stochastic modeling of the irregular heartbeats and the reduced contractility of the heart. AF can be here analyzed by means of a wide number of hemodynamic parameters and avoiding the presence of other pathologies, which usually accompany AF. Reduced cardiac output with correlated drop of ejection fraction and decreased amount of energy converted to work by the heart during blood pumping, as well as higher left atrial volumes and pressures are some of the most representative results aligned with the existing clinical literature and here emerging during acute AF. The present modeling, providing new insights on cardiovascular variables which are difficult to measure and rarely reported in literature, turns out to be an efficient and powerful tool for a deeper comprehension and prediction of the arrythmia impact on the whole cardiovascular system.

  20. Analysis of direct contact membrane distillation based on a lumped-parameter dynamic predictive model

    KAUST Repository

    Karam, Ayman M.

    2016-10-03

    Membrane distillation (MD) is an emerging technology that has a great potential for sustainable water desalination. In order to pave the way for successful commercialization of MD-based water desalination techniques, adequate and accurate dynamical models of the process are essential. This paper presents the predictive capabilities of a lumped-parameter dynamic model for direct contact membrane distillation (DCMD) and discusses the results under wide range of steady-state and dynamic conditions. Unlike previous studies, the proposed model captures the time response of the spacial temperature distribution along the flow direction. It also directly solves for the local temperatures at the membrane interfaces, which allows to accurately model and calculate local flux values along with other intrinsic variables of great influence on the process, like the temperature polarization coefficient (TPC). The proposed model is based on energy and mass conservation principles and analogy between thermal and electrical systems. Experimental data was collected to validated the steady-state and dynamic responses of the model. The obtained results shows great agreement with the experimental data. The paper discusses the results of several simulations under various conditions to optimize the DCMD process efficiency and analyze its response. This demonstrates some potential applications of the proposed model to carry out scale up and design studies. © 2016

  1. Analysis of direct contact membrane distillation based on a lumped-parameter dynamic predictive model

    KAUST Repository

    Karam, Ayman M.; Alsaadi, Ahmad Salem; Ghaffour, NorEddine; Laleg-Kirati, Taous-Meriem

    2016-01-01

    Membrane distillation (MD) is an emerging technology that has a great potential for sustainable water desalination. In order to pave the way for successful commercialization of MD-based water desalination techniques, adequate and accurate dynamical models of the process are essential. This paper presents the predictive capabilities of a lumped-parameter dynamic model for direct contact membrane distillation (DCMD) and discusses the results under wide range of steady-state and dynamic conditions. Unlike previous studies, the proposed model captures the time response of the spacial temperature distribution along the flow direction. It also directly solves for the local temperatures at the membrane interfaces, which allows to accurately model and calculate local flux values along with other intrinsic variables of great influence on the process, like the temperature polarization coefficient (TPC). The proposed model is based on energy and mass conservation principles and analogy between thermal and electrical systems. Experimental data was collected to validated the steady-state and dynamic responses of the model. The obtained results shows great agreement with the experimental data. The paper discusses the results of several simulations under various conditions to optimize the DCMD process efficiency and analyze its response. This demonstrates some potential applications of the proposed model to carry out scale up and design studies. © 2016

  2. Determination of gold in lump by the gamma-activation analysis method

    International Nuclear Information System (INIS)

    Yantsen, V.A.; Ermakov, K.S.

    2006-01-01

    Full text: In the report the installation is described used in the Central gamma-activation analysis laboratory (CGAAL) for express quantitative determination of gold concentration in large powdered samples. The method of gold contents determination for non-crushed samples (pieces up to 100 mm). The given gamma-activation analysis method is widely used in mining industry, and at researches related with selection of optimal technological circuits designed for sorting the pieces of ore and rock materials. By developing this method it is now possible to create the technological collection of separated pieces by size, large by the amount of samples, imitating various sorts (by gold concentration in them) and types (by elemental composition) ores, and, based on these collection, to compare the efficiencies of various enrichment methods by knowing in advance the concentrations of gold in these lumps being the final sorting products. The Gamma-activation analysis method of large pieces is mainly used as foundation for the x-ray radiometric (XRR) method of pieces separation of gold-bearing ores from the deposits mined by the Navoi mining combine. It allows significant increase in the rate of research and development works on selection of the most reliable separation characteristics. Based on these one can develop optimal technological circuits for ore enrichment with portion sorting methods. (author)

  3. Frequency Combs in a Lumped-Element Josephson-Junction Circuit

    Science.gov (United States)

    Khan, Saeed; Türeci, Hakan E.

    2018-04-01

    We investigate the dynamics of a microwave-driven Josephson junction capacitively coupled to a lumped-element L C oscillator. In the regime of driving where the Josephson junction can be approximated as a Kerr oscillator, this minimal nonlinear system has been previously shown to exhibit a bistability in phase and amplitude. In the present study, we characterize the full phase diagram and show that besides a parameter regime exhibiting bistability, there is also a regime of self-oscillations characterized by a frequency comb in its spectrum. We discuss the mechanism of comb generation which appears to be different from those studied in microcavity frequency combs and mode-locked lasers. We then address the fate of the comblike spectrum in the regime of strong quantum fluctuations, reached when nonlinearity becomes the dominant scale with respect to dissipation. We find that the nonlinearity responsible for the emergence of the frequency combs also leads to its dephasing, leading to broadening and ultimate disappearance of sharp spectral peaks. Our study explores the fundamental question of the impact of quantum fluctuations for quantum systems which do not possess a stable fixed point in the classical limit.

  4. Development of CAP code for nuclear power plant containment: Lumped model

    International Nuclear Information System (INIS)

    Hong, Soon Joon; Choo, Yeon Joon; Hwang, Su Hyun; Lee, Byung Chul; Ha, Sang Jun

    2015-01-01

    Highlights: • State-of-art containment analysis code, CAP, has been developed. • CAP uses 3-field equations, water level oriented upwind scheme, local head model. • CAP has a function of linked calculation with reactor coolant system code. • CAP code assessments showed appropriate prediction capabilities. - Abstract: CAP (nuclear Containment Analysis Package) code has been developed in Korean nuclear society for the analysis of nuclear containment thermal hydraulic behaviors including pressure and temperature trends and hydrogen concentration. Lumped model of CAP code uses 2-phase, 3-field equations for fluid behaviors, and has appropriate constitutive equations, 1-dimensional heat conductor model, component models, trip and control models, and special process models. CAP can run in a standalone mode or a linked mode with a reactor coolant system analysis code. The linked mode enables the more realistic calculation of a containment response and is expected to be applicable to a more complicated advanced plant design calculation. CAP code assessments were carried out by gradual approaches: conceptual problems, fundamental phenomena, component and principal phenomena, experimental validation, and finally comparison with other code calculations on the base of important phenomena identifications. The assessments showed appropriate prediction capabilities of CAP

  5. A CPW-Fed Quasi-PIFA Antenna Using Quasi-Lumped Resonators for Mobile Phones

    Directory of Open Access Journals (Sweden)

    Majid Rafiee

    2015-01-01

    Full Text Available A novel single CPW-fed Quasi-Planar Inverted-F Antenna (PIFA using quasi-lumped elements is developed for mobile communication handheld terminals operating at 2.6 GHz. The antenna is composed of an inductor covered by a set of interdigital and parasitic capacitors. The proposed antenna achieves a measured bandwidth of 11% for return loss with the antenna gain of about 4 dBi. The antenna is designed in single layer (zero height which is appropriate to be used in thin devices where a small room is considered for the antenna. The proposed antenna is suitable for use in Long Term Evolution band 7. The operating frequency of introduced antenna depends on the number of interdigital fingers and inductor length rather than the total resonator patch only, so that the operating frequency can be altered while the total patch size remains unchanged. The calculated operating frequency is confirmed by simulation and measurement. Also the dipole-like simulated radiation pattern is confirmed by measurement.

  6. Compact triple band-stop filter using novel epsilon-shaped metamaterial with lumped capacitor

    Science.gov (United States)

    Ali, W. A. E.; Hamdalla, M. Z. M.

    2018-04-01

    This paper presents the design of a novel epsilon-shaped metamaterial unit cell structure that is applicable for single-band and multi-band applications. A closed-form formulas to control the resonance frequencies of the proposed design are included. The proposed unit cell, which exhibits negative permeability at its frequency bands, is etched from the ground plane to form a band-stop filter. The filter design is constructed to validate the band-notched characteristics of the proposed unit cell. A lumped capacitor is inserted for size reduction purpose in addition to multi-resonance generation. The fundamental resonance frequency is translated from 3.62 GHz to 2.45 GHz, which means that the filter size will be more compact (more than 32% size reduction). The overall size of the proposed filter is 13 × 6 × 1.524 mm3, where the electrical size is 0.221λg × 0.102λg × 0.026λg at the lower frequency band (2.45 GHz). Two other resonance frequencies are generated at 5.3 GHz and 9.2 GHz, which confirm the multi-band behavior of the proposed filter. Good agreement between simulated and measured characteristics of the fabricated filter prototype is achieved.

  7. Parallelized FDTD simulation for flat-plate bounded wave EMP simulator with lumped terminator

    International Nuclear Information System (INIS)

    Zhu Xiangqin; Chen Weiqing; Chen Zaigao; Cai Libing; Wang Jianguo

    2013-01-01

    A parallelized finite-difference time-domain(FDTD) method for simulating the bounded wave electromagnetic pulse (EMP) simulator with lumped terminator and parallel plate is presented. The effects of several model-parameters on the simulator to the fields in the working volume are simulated and analyzed. The results show that if the width of the lower PEC plate is(or is bigger than)1.5 times that of the upper plate of working volume, the projection length of front transitional section does not have a significant effect on the rise-times of electric fields at the points near the front transitional section, and the rise-times of electric fields at the points near the working volume center decrease as the projection length increases, but the decrement of rise-time decreases. The rise-times of E z at all points also decrease as the lower PEC plate's width increases, but the decrements of rise-time decreases. If the projection length of the front transitional section is fixed, the good results can not be obtained by increasing or decreasing the height of the simulator only, however, which has an optimal value. (authors)

  8. A simplified lumped model for the optimization of post-buckled beam architecture wideband generator

    Science.gov (United States)

    Liu, Weiqun; Formosa, Fabien; Badel, Adrien; Hu, Guangdi

    2017-11-01

    Buckled beams structures are a classical kind of bistable energy harvesters which attract more and more interests because of their capability to scavenge energy over a large frequency band in comparison with linear generator. The usual modeling approach uses the Galerkin mode discretization method with relatively high complexity, while the simplification with a single-mode solution lacks accuracy. It stems on the optimization of the energy potential features to finally define the physical and geometrical parameters. Therefore, in this paper, a simple lumped model is proposed with explicit relationship between the potential shape and parameters to allow efficient design of bistable beams based generator. The accuracy of the approximation model is studied with the effectiveness of application analyzed. Moreover, an important fact, that the bending stiffness has little influence on the potential shape with low buckling level and the sectional area determined, is found. This feature extends the applicable range of the model by utilizing the design of high moment of inertia. Numerical investigations demonstrate that the proposed model is a simple and reliable tool for design. An optimization example of using the proposed model is demonstrated with satisfactory performance.

  9. Improving the temporal transposability of lumped hydrological models on twenty diversified U.S. watersheds

    Directory of Open Access Journals (Sweden)

    G. Seiller

    2015-03-01

    Full Text Available Study region: Twenty diversified U.S. watersheds. Study focus: Identifying optimal parameter sets for hydrological modeling on a specific catchment remains an important challenge for numerous applied and research projects. This is particularly the case when working under contrasted climate conditions that question the temporal transposability of the parameters. Methodologies exist, mainly based on Differential Split Sample Tests, to examine this concern. This work assesses the improved temporal transposability of a multimodel implementation, based on twenty dissimilar lumped conceptual structures and on twenty U.S. watersheds, over the performance of the individual models. New hydrological insights for the region: Individual and collective temporal transposabilities are analyzed and compared on the twenty studied watersheds. Results show that individual models performances on contrasted climate conditions are very dissimilar depending on test period and watershed, without the possibility to identify a best solution in all circumstances. They also confirm that performance and robustness are clearly enhanced using an ensemble of rainfall-runoff models instead of individual ones. The use of (calibrated weight averaged multimodels further improves temporal transposability over simple averaged ensemble, in most instances, confirming added-value of this approach but also the need to evaluate how individual models compensate each other errors. Keywords: Rainfall-runoff modeling, Multimodel approach, Differential Split Sample Test, Deterministic combination, Outputs averaging

  10. A lumped parameter core dynamics model for MTR type research reactors under natural convection regime

    International Nuclear Information System (INIS)

    Ardaneh, Kazem; Zaferanlouei, Salman

    2013-01-01

    Highlights: ► A model is presented to simulate the reactivity insertion transient in MTR reactors. ► Transient dynamics of IAEA 10 MW MTR type research reactor are evaluated. ► Maximum unprotected reactivity insertion for safe condition is calculated. ► The model predictions are validated with corresponding results in the literature. - Abstract: On the basis of lumped parameter modeling of both the kinetic and thermal–hydraulic effects, a reasonably accurate simplified model has been developed to predict the dynamic response of MTR reactors following to an unprotected reactivity insertion under natural convection regime. By this model the reactor transient behavior at a given initial steady-state can be solved by a set of ordinary differential equations. The model predictions have an acceptable consent with corresponding results of reactivity insertion transients analyzed in the literature. The inherent safety characteristics of MTR research reactors utilizing natural convection is clearly demonstrated by the expanded model. The safety margin of reactor operating is selected ONB condition and thereby the proposed model determines that any slight increase in the value of $0.73 for inserted reactivity will cause the maximum cladding surface temperature to exceed the ONB condition

  11. Parameter sensitivity analysis of a lumped-parameter model of a chain of lymphangions in series.

    Science.gov (United States)

    Jamalian, Samira; Bertram, Christopher D; Richardson, William J; Moore, James E

    2013-12-01

    Any disruption of the lymphatic system due to trauma or injury can lead to edema. There is no effective cure for lymphedema, partly because predictive knowledge of lymphatic system reactions to interventions is lacking. A well-developed model of the system could greatly improve our understanding of its function. Lymphangions, defined as the vessel segment between two valves, are the individual pumping units. Based on our previous lumped-parameter model of a chain of lymphangions, this study aimed to identify the parameters that affect the system output the most using a sensitivity analysis. The system was highly sensitive to minimum valve resistance, such that variations in this parameter caused an order-of-magnitude change in time-average flow rate for certain values of imposed pressure difference. Average flow rate doubled when contraction frequency was increased within its physiological range. Optimum lymphangion length was found to be some 13-14.5 diameters. A peak of time-average flow rate occurred when transmural pressure was such that the pressure-diameter loop for active contractions was centered near maximum passive vessel compliance. Increasing the number of lymphangions in the chain improved the pumping in the presence of larger adverse pressure differences. For a given pressure difference, the optimal number of lymphangions increased with the total vessel length. These results indicate that further experiments to estimate valve resistance more accurately are necessary. The existence of an optimal value of transmural pressure may provide additional guidelines for increasing pumping in areas affected by edema.

  12. Moving Beyond the “Lump-Sum”: A Case Study of Partnership for Positive Social Change

    Directory of Open Access Journals (Sweden)

    Anne Bunde-Birouste

    2010-08-01

    Full Text Available Based on a foundation of an integrated sport program for positive social change and health promotion, this paper presents a case study of the relationship between a corporate sponsor (JP Morgan, and a community-based health promotion/social change organization (Football United. The paper articulates the various issues that arise in management of such a program, and the involvement of sponsors in its operation. Illustrated through the JP Morgan - Football United case study, the paper explores: the difficulties of maintaining a program that remains faithful to the expectations and demands of each stakeholder group involved; the challenges involved in harnessing support for a program when moving beyond the one-dimensional transfer of funds; the different needs and expectations of/for volunteers this type of complex health promotion intervention. This case study has been written to propose that an “integrated partnership” between a corporate body and a social change organization can produce significant advantages beyond the scope of uncomplicated financial contribution The key feature documented is that corporate investment can move beyond abstract “lump-sum” social responsibility, towards targeted contributions to detailed outcomes through sustainable and meaningful involvement in a health promotion framework. This in turn equates to funding stability and a more empowering partnership for the health promotion/social change organization.

  13. Genetic Algorithms for Estimating Effective Parameters in a Lumped Reactor Model for Reactivity Predictions

    International Nuclear Information System (INIS)

    Marseguerra, Marzio; Zio, Enrico

    2001-01-01

    The control system of a reactor should be able to predict, in real time, the amount of reactivity to be inserted (e.g., by control rod movements and boron injection and dilution) to respond to a given electrical load demand or to undesired, accidental transients. The real-time constraint renders impractical the use of a large, detailed dynamic reactor code. One has, then, to resort to simplified analytical models with lumped effective parameters suitably estimated from the reactor data.The simple and well-known Chernick model for describing the reactor power evolution in the presence of xenon is considered and the feasibility of using genetic algorithms for estimating the effective nuclear parameters involved and the initial nonmeasurable xenon and iodine conditions is investigated. This approach has the advantage of counterbalancing the inherent model simplicity with the periodic reestimation of the effective parameter values pertaining to each reactor on the basis of its recent history. By so doing, other effects, such as burnup, are automatically taken into account

  14. An approach for characterization and lumping of plus fractions of heavy oil

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, I.; Hamouda, A.A. [Stavanger Univ., Stavanger (Norway)

    2008-10-15

    The constituents of hydrocarbons can be classified as either well-defined components or undefined petroleum fractions. This paper presented a newly developed method for characterizing plus fractions of heavy oil, which is particularly important for fluids with high molecular weight and high density. Characterization of plus fractions typically consists of 3 parts, notably splitting the fraction into a certain number of components groups called single carbon number (SCN); estimating the physico-chemical properties of the SCN; and lumping the generated SCN. SCN groups contain hundreds of isomers/components with the same number of carbon atoms. A unique molecular weight cannot be assigned for each SCN group because of the uncertainty of the isomers/components present. Therefore, this work focused on finding a new approach to characterize the undetermined fraction by first splitting the carbon number fraction into a representative number of SCN and then calculating their mole fraction and molecular weight. The method was based on the relationships between three parameter gamma distribution (TPG), experimental mole fraction, molecular weight and SCN data obtained from literature and industry. The method was applied to 5 different heavy oil sample fluids which all showed a left skewed distribution of the mole fraction as a function of carbon number. The predicted molecular weight was found to be close to the generalized molecular weight associated with carbon number, but it differed from one sample to another. 19 refs., 11 tabs., 15 figs.

  15. The influence of lumping on the behavior of reservoir with light oil and CO2

    Energy Technology Data Exchange (ETDEWEB)

    Scanavini, Helena Finardi Alvares [Universidade Estadual de Campinas (UNISIM/UNICAMP), SP (Brazil). Dept. de Engenharia de Petroleo. Pesquisa em Simulacao e Gerenciamento de Reservatorios; Schiozer, Denis Jose [Universidade Estadual de Campinas (DEP/FEM/UNICAMP), SP (Brazil). Fac. de Engenharia Mecanica. Dept. de Engenharia de Petroleo

    2012-07-01

    Compositional simulation demands a large number of equations and functions to be solved, once fluid properties depend on reservoir pressure and temperature and also on fluid composition. As a consequence, the number of components used influences considerably in the simulation run time and accuracy: more components yield more equations to be solved with expected higher run time. Giant petroleum fields discovered recently in Brazil (pre-salt reservoirs) demand compositional simulation due to the fluid characteristics (light oil with the presence of CO2). However, the computational time can be a limitation because of the number of grid blocks that are necessary to represent the reservoir. So, reducing the number of components is an important step for the simulation models. Under this context, this paper presents a study on the influence of different lumping clusters, used to reduce the number of components in a volatile oil, on reservoir simulation. Phase diagram, saturation pressure and simulation results were used for comparison purposes. The best results were obtained for the cases with 14, 9 and 7 pseudo components, which represented correctly the original fluid, reducing till three times the simulation run time, for the same production volumes of oil and gas. (author)

  16. New lumped-mass-stick model based on modal characteristics of structures: development and application to a nuclear containment building

    Science.gov (United States)

    Roh, Hwasung; Lee, Huseok; Lee, Jong Seh

    2013-06-01

    In this study, a new lumped-mass-stick model (LMSM) is developed based on the modal characteristics of a structure such as eigenvalues and eigenvectors. The simplified model, named the "frequency adaptive lumped-massstick model," hasonly a small number of stick elements and nodes to provide the same natural frequencies of the structure and is applied to a nuclear containment building. To investigate the numerical performance of the LMSM, a time history analysis is carried out on both the LMSM and the finite element model (FEM) for a nuclear containment building. A comparison of the results shows that the dynamic responses of the LMSM in terms of displacement and acceleration are almost identical to those of the FEM. In addition, the results in terms of fl oor response spectra at certain elevations are also in good agreement.

  17. Isolated tear of the tendon to the medial head of gastrocnemius presenting as a painless lump in the calf.

    Science.gov (United States)

    Watura, Christopher; Harries, William

    2009-01-01

    We report on a case of isolated tear of the medial head of gastrocnemius tendon. The patient presented with a painless lump in the right calf and denied any prior history of trauma or strain to the leg. A longitudinal split of the tendon was demonstrated at ultrasound and magnetic resonance imaging (MRI). There were no other abnormalities and the gastrocnemius muscle was normal. There are no reports in the literature of isolated gastrocnemius tendon tear. To date the calf muscle complex injury described in this area is tearing of the medial head of gastrocnemius muscle, sometimes referred to as "tennis leg". We conclude that an isolated tear of the tendon to the medial head of gastrocnemius should be considered in the differential diagnosis of a lump or swelling in the upper medial area of the calf and we recommend ultrasound or MRI as the investigations of choice.

  18. Drop-on-Demand Inkjet Printhead Performance Enhancement by Dynamic Lumped Element Modeling for Printable Electronics Fabrication

    Directory of Open Access Journals (Sweden)

    Maowei He

    2014-01-01

    Full Text Available The major challenge in printable electronics fabrication is the print resolution and accuracy. In this paper, the dynamic lumped element model (DLEM is proposed to directly simulate an inkjet-printed nanosilver droplet formation process and used for predictively controlling jetting characteristics. The static lumped element model (LEM previously developed by the authors is extended to dynamic model with time-varying equivalent circuits to characterize nonlinear behaviors of piezoelectric printhead. The model is then used to investigate how performance of the piezoelectric ceramic actuator influences jetting characteristics of nanosilver ink. Finally, the proposed DLEM is applied to predict the printing quality using nanosilver ink. Experimental results show that, compared to other analytic models, the proposed DLEM has a simpler structure with the sufficient simulation and prediction accuracy.

  19. Uncertainty quantification in flux balance analysis of spatially lumped and distributed models of neuron-astrocyte metabolism.

    Science.gov (United States)

    Calvetti, Daniela; Cheng, Yougan; Somersalo, Erkki

    2016-12-01

    Identifying feasible steady state solutions of a brain energy metabolism model is an inverse problem that allows infinitely many solutions. The characterization of the non-uniqueness, or the uncertainty quantification of the flux balance analysis, is tantamount to identifying the degrees of freedom of the solution. The degrees of freedom of multi-compartment mathematical models for energy metabolism of a neuron-astrocyte complex may offer a key to understand the different ways in which the energetic needs of the brain are met. In this paper we study the uncertainty in the solution, using techniques of linear algebra to identify the degrees of freedom in a lumped model, and Markov chain Monte Carlo methods in its extension to a spatially distributed case. The interpretation of the degrees of freedom in metabolic terms, more specifically, glucose and oxygen partitioning, is then leveraged to derive constraints on the free parameters to guarantee that the model is energetically feasible. We demonstrate how the model can be used to estimate the stoichiometric energy needs of the cells as well as the household energy based on the measured oxidative cerebral metabolic rate of glucose and glutamate cycling. Moreover, our analysis shows that in the lumped model the net direction of lactate dehydrogenase (LDH) in the cells can be deduced from the glucose partitioning between the compartments. The extension of the lumped model to a spatially distributed multi-compartment setting that includes diffusion fluxes from capillary to tissue increases the number of degrees of freedom, requiring the use of statistical sampling techniques. The analysis of the distributed model reveals that some of the conclusions valid for the spatially lumped model, e.g., concerning the LDH activity and glucose partitioning, may no longer hold.

  20. Isolated tear of the tendon to the medial head of gastrocnemius presenting as a painless lump in the calf

    OpenAIRE

    Watura, Christopher; Harries, William

    2009-01-01

    We report on a case of isolated tear of the medial head of gastrocnemius tendon. The patient presented with a painless lump in the right calf and denied any prior history of trauma or strain to the leg. A longitudinal split of the tendon was demonstrated at ultrasound and magnetic resonance imaging (MRI). There were no other abnormalities and the gastrocnemius muscle was normal. There are no reports in the literature of isolated gastrocnemius tendon tear. To date the calf muscle complex injur...

  1. Systematic reduction of complex tropospheric chemical mechanisms, Part II: Lumping using a time-scale based approach

    Directory of Open Access Journals (Sweden)

    L. E. Whitehouse

    2004-01-01

    Full Text Available This paper presents a formal method of species lumping that can be applied automatically to intermediate compounds within detailed and complex tropospheric chemical reaction schemes. The method is based on grouping species with reference to their chemical lifetimes and reactivity structures. A method for determining the forward and reverse transformations between individual and lumped compounds is developed. Preliminary application to the Leeds Master Chemical Mechanism (MCMv2.0 has led to the removal of 734 species and 1777 reactions from the scheme, with minimal degradation of accuracy across a wide range of test trajectories relevant to polluted tropospheric conditions. The lumped groups are seen to relate to groups of peroxy acyl nitrates, nitrates, carbonates, oxepins, substituted phenols, oxeacids and peracids with similar lifetimes and reaction rates with OH. In combination with other reduction techniques, such as sensitivity analysis and the application of the quasi-steady state approximation (QSSA, a reduced mechanism has been developed that contains 35% of the number of species and 40% of the number of reactions compared to the full mechanism. This has led to a speed up of a factor of 8 in terms of computer calculation time within box model simulations.

  2. Numerical analysis of macro-crack formation behavior within the lump coke; Cokes sonai kiretsu shinten kiko no kaiseki

    Energy Technology Data Exchange (ETDEWEB)

    Aoki, H; Sato, H; Miura, T [Tohoku University, Sendai (Japan). Faculty of Engineering

    1995-03-15

    The thermal stress analysis within lump coke was studied in order to investigate macro-crack formation and deformation behavior which strongly influence heat and mass transfer in a coke oven chamber. The dilatation of plastic layer, heating rate dependence of thermophysical and mechanical properties of coal/coke, creep in the plastic and semi-coke layers, macro-crack propagation and radiative heat transfer within the macro-crack were considered in an analytical model. The macro-crack propagation was determined from the estimated crack tip stress intensity factor, K{sub I}, at the macro-crack tip compared with the plane strain fracture toughness, K{sub IC}, through the unsteady-state calculation. Calculated results on crack formation and deformation behavior of lump coke were in good agreement with experimental observations in a laboratory-scale oven chamber. The analytical model could predict micro-crack formation within the lump coke normal to the heated wall and the coke surface close to the heated wall. 12 refs., 13 figs.

  3. Path lumping: An efficient algorithm to identify metastable path channels for conformational dynamics of multi-body systems

    Science.gov (United States)

    Meng, Luming; Sheong, Fu Kit; Zeng, Xiangze; Zhu, Lizhe; Huang, Xuhui

    2017-07-01

    Constructing Markov state models from large-scale molecular dynamics simulation trajectories is a promising approach to dissect the kinetic mechanisms of complex chemical and biological processes. Combined with transition path theory, Markov state models can be applied to identify all pathways connecting any conformational states of interest. However, the identified pathways can be too complex to comprehend, especially for multi-body processes where numerous parallel pathways with comparable flux probability often coexist. Here, we have developed a path lumping method to group these parallel pathways into metastable path channels for analysis. We define the similarity between two pathways as the intercrossing flux between them and then apply the spectral clustering algorithm to lump these pathways into groups. We demonstrate the power of our method by applying it to two systems: a 2D-potential consisting of four metastable energy channels and the hydrophobic collapse process of two hydrophobic molecules. In both cases, our algorithm successfully reveals the metastable path channels. We expect this path lumping algorithm to be a promising tool for revealing unprecedented insights into the kinetic mechanisms of complex multi-body processes.

  4. Generalized Kutta–Joukowski theorem for multi-vortex and multi-airfoil flow (a lumped vortex model

    Directory of Open Access Journals (Sweden)

    Bai Chenyuan

    2014-02-01

    Full Text Available For purpose of easy identification of the role of free vortices on the lift and drag and for purpose of fast or engineering evaluation of forces for each individual body, we will extend in this paper the Kutta–Joukowski (KJ theorem to the case of inviscid flow with multiple free vortices and multiple airfoils. The major simplification used in this paper is that each airfoil is represented by a lumped vortex, which may hold true when the distances between vortices and bodies are large enough. It is found that the Kutta–Joukowski theorem still holds provided that the local freestream velocity and the circulation of the bound vortex are modified by the induced velocity due to the outside vortices and airfoils. We will demonstrate how to use the present result to identify the role of vortices on the forces according to their position, strength and rotation direction. Moreover, we will apply the present results to a two-cylinder example of Crowdy and the Wagner example to demonstrate how to perform fast force approximation for multi-body and multi-vortex problems. The lumped vortex assumption has the advantage of giving such kinds of approximate results which are very easy to use. The lack of accuracy for such a fast evaluation will be compensated by a rigorous extension, with the lumped vortex assumption removed and with vortex production included, in a forthcoming paper.

  5. A weighted least-squares lump correction algorithm for transmission-corrected gamma-ray nondestructive assay

    International Nuclear Information System (INIS)

    Prettyman, T.H.; Sprinkle, J.K. Jr.; Sheppard, G.A.

    1993-01-01

    With transmission-corrected gamma-ray nondestructive assay instruments such as the Segmented Gamma Scanner (SGS) and the Tomographic Gamma Scanner (TGS) that is currently under development at Los Alamos National Laboratory, the amount of gamma-ray emitting material can be underestimated for samples in which the emitting material consists of particles or lumps of highly attenuating material. This problem is encountered in the assay of uranium and plutonium-bearing samples. To correct for this source of bias, we have developed a least-squares algorithm that uses transmission-corrected assay results for several emitted energies and a weighting function to account for statistical uncertainties in the assay results. The variation of effective lump size in the fitted model is parameterized; this allows the correction to be performed for a wide range of lump-size distributions. It may be possible to use the reduced chi-squared value obtained in the fit to identify samples in which assay assumptions have been violated. We found that the algorithm significantly reduced bias in simulated assays and improved SGS assay results for plutonium-bearing samples. Further testing will be conducted with the TGS, which is expected to be less susceptible than the SGS to systematic source of bias

  6. Vozy formule 1

    OpenAIRE

    Zbožínek, Adam

    2009-01-01

    Tato práce uvádí základní pravidla a předpoklady pro konstrukci a použití vozů formule 1. Hlavní zaměření je na aerodynamiku, která je nejdůležitější disciplínou v tomto motoristickém sportu, dále je tato práce zaměřena na základní faktory týkající se motoru vozu, kol, nové technologie KERS a provedení volantu. This work shows basic rules and conditions for construction and use of cars formula 1. The main part of this work focus on the aerodynamics which is the most important discipline of...

  7. Assessment of strategy formulation

    DEFF Research Database (Denmark)

    Acur, Nuran; Englyst, Linda

    2006-01-01

    of the success criteria through face-to-face interviews with 46 managers, workshops involving 40 managers, and two in-depth case studies. The success criteria have been slightly modified due to the empirical results, to yield the assessment tool. Findings – The resulting assessment tool integrates three generic...... approaches to strategy assessment, namely the goal-centred, comparative and improvement approaches, as found in the literature. Furthermore, it encompasses three phases of strategy formulation processes: strategic thinking, strategic planning and embedding of strategy. The tool reflects that the different......, but cases and managerial perceptions indicate that the need for accurate and detailed plans might be overrated in the literature, as implementation relies heavily on continuous improvement and empowerment. Concerning embedding, key aspects relate both to the goal-centred and improvement approaches, while...

  8. airGRteaching: an R-package designed for teaching hydrology with lumped hydrological models

    Science.gov (United States)

    Thirel, Guillaume; Delaigue, Olivier; Coron, Laurent; Andréassian, Vazken; Brigode, Pierre

    2017-04-01

    Lumped hydrological models are useful and convenient tools for research, engineering and educational purposes. They propose catchment-scale representations of the precipitation-discharge relationship. Thanks to their limited data requirements, they can be easily implemented and run. With such models, it is possible to simulate a number of hydrological key processes over the catchment with limited structural and parametric complexity, typically evapotranspiration, runoff, underground losses, etc. The Hydrology Group at Irstea (Antony) has been developing a suite of rainfall-runoff models over the past 30 years. This resulted in a suite of models running at different time steps (from hourly to annual) applicable for various issues including water balance estimation, forecasting, simulation of impacts and scenario testing. Recently, Irstea has developed an easy-to-use R-package (R Core Team, 2016), called airGR (Coron et al., 2016, 2017), to make these models widely available. Although its initial target public was hydrological modellers, the package is already used for educational purposes. Indeed, simple models allow for rapidly visualising the effects of parameterizations and model components on flows hydrographs. In order to avoid the difficulties that students may have when manipulating R and datasets, we developed (Delaigue and Coron, 2016): - Three simplified functions to prepare data, calibrate a model and run a simulation - Simplified and dynamic plot functions - A shiny (Chang et al., 2016) interface that connects this R-package to a browser-based visualisation tool. On this interface, the students can use different hydrological models (including the possibility to use a snow-accounting model), manually modify their parameters and automatically calibrate their parameters with diverse objective functions. One of the visualisation tabs of the interface includes observed precipitation and temperature, simulated snowpack (if any), observed and simulated

  9. Use of Ventricular Assist Device in Univentricular Physiology: The Role of Lumped Parameter Models.

    Science.gov (United States)

    Di Molfetta, Arianna; Ferrari, Gianfranco; Filippelli, Sergio; Fresiello, Libera; Iacobelli, Roberta; Gagliardi, Maria G; Amodeo, Antonio

    2016-05-01

    Failing single-ventricle (SV) patients might benefit from ventricular assist devices (VADs) as a bridge to heart transplantation. Considering the complex physiopathology of SV patients and the lack of established experience, the aim of this work was to realize and test a lumped parameter model of the cardiovascular system, able to simulate SV hemodynamics and VAD implantation effects. Data of 30 SV patients (10 Norwood, 10 Glenn, and 10 Fontan) were retrospectively collected and used to simulate patients' baseline. Then, the effects of VAD implantation were simulated. Additionally, both the effects of ventricular assistance and cavopulmonary assistance were simulated in different pathologic conditions on Fontan patients, including systolic dysfunction, diastolic dysfunction, and pulmonary vascular resistance increment. The model can reproduce patients' baseline well. Simulation results suggest that the implantation of VAD: (i) increases the cardiac output (CO) in all the three palliation conditions (Norwood 77.2%, Glenn 38.6%, and Fontan 17.2%); (ii) decreases the SV external work (SVEW) (Norwood 55%, Glenn 35.6%, and Fontan 41%); (iii) increases the mean pulmonary arterial pressure (Pap) (Norwood 39.7%, Glenn 12.1%, and Fontan 3%). In Fontan circulation, with systolic dysfunction, the left VAD (LVAD) increases CO (35%), while the right VAD (RVAD) determines a decrement of inferior vena cava pressure (Pvci) (39%) with 34% increment of CO. With diastolic dysfunction, the LVAD increases CO (42%) and the RVAD decreases the Pvci. With pulmonary vascular resistance increment, the RVAD allows the highest CO (50%) increment with the highest decrement of Pvci (53%). The single ventricular external work (SVEW) increases (decreases) increasing the VAD speed in cavopulmonary (ventricular) assistance. Numeric models could be helpful in this challenging and innovative field to support patients and VAD selection to optimize the clinical outcome and personalize the therapy

  10. On the treatment of plane fusion front in lumped parameter thermal models with convection

    International Nuclear Information System (INIS)

    Le Tellier, R.; Skrzypek, E.; Saas, L.

    2017-01-01

    Highlights: • Solid phase approximations for a two-phase Stefan fusion problem with convection are analyzed. • A reference solution combines integral conservation eqs and a FE solution of the 1D heat equation. • Numerical results are presented for a transient in light water reactor severe accident analysis. • The models performances are highlighted on fusion transients in terms of Biot and Stefan numbers. - Abstract: Within the framework of lumped parameter models for integral codes, this paper focuses on the modeling of a two-phase Stefan fusion problem with natural convection in the liquid phase. In particular, this specific Stefan problem is of interest when studying corium pool behavior in the framework of light water reactor severe accident analysis. The objective of this research is to analyze the applicability of different approximations related to the modeling of the solid phase in terms of boundary heat flux closure relations. Three different approximations are considered: a quadratic profile based model, a model where a parameter controls the power partitioning at the interface and the steady state conduction assumption. These models are compared with an accurate front-tracking solution of this plane fusion front problem. This “reference” is obtained by combining the same integral conservation equations as the approximate models with a mesh-based solution of the 1D heat equation. Numerical results are discussed for a typical configuration of interest for corium pool analysis. Different fusion transients (constructed from nondimensionalization considerations in terms of Biot and Stefan numbers) are used in order to highlight the potential and limitations of the different approximations.

  11. Baseline LAW Glass Formulation Testing

    International Nuclear Information System (INIS)

    Kruger, Albert A.; Mooers, Cavin; Bazemore, Gina; Pegg, Ian L.; Hight, Kenneth; Lai, Shan Tao; Buechele, Andrew; Rielley, Elizabeth; Gan, Hao; Muller, Isabelle S.; Cecil, Richard

    2013-01-01

    The major objective of the baseline glass formulation work was to develop and select glass formulations that are compliant with contractual and processing requirements for each of the LAW waste streams. Other objectives of the work included preparation and characterization of glasses with respect to the properties of interest, optimization of sulfate loading in the glasses, evaluation of ability to achieve waste loading limits, testing to demonstrate compatibility of glass melts with melter materials of construction, development of glass formulations to support ILAW qualification activities, and identification of glass formulation issues with respect to contract specifications and processing requirements

  12. Analysis of groundwater discharge with a lumped-parameter model, using a case study from Tajikistan

    Science.gov (United States)

    Pozdniakov, S. P.; Shestakov, V. M.

    A lumped-parameter model of groundwater balance is proposed that permits an estimate of discharge variability in comparison with the variability of recharge, by taking into account the influence of aquifer parameters. Recharge-discharge relationships are analysed with the model for cases of deterministic and stochastic recharge time-series variations. The model is applied to study the temporal variability of groundwater discharge in a river valley in the territory of Tajikistan, an independent republic in Central Asia. Résumé Un modèle global de bilan d'eau souterraine a été développé pour estimer la variabilité de l'écoulement par rapport à celle de la recharge, en prenant en compte l'influence des paramètres de l'aquifère. Les relations entre recharge et écoulement sont analysées à l'aide du modèle pour des variations des chroniques de recharge soit déterministes, soit stochastiques. Le modèle est appliquéà l'étude de la variabilité temporelle de l'écoulement souterrain vers une rivière, dans le Tadjikistan, une république indépendante d'Asie centrale. Resumen Se propone un modelo de parámetros concentrados para realizar el balance de aguas subterráneas, el cual permite estimar la variabilidad en la descarga con respecto a la variabilidad en la recarga, en función de los parámetros que caracterizan el acuífero. Las relaciones entre recarga y descarga se analizan con el modelo para distintos casos de series temporales de recarga, tanto deterministas como estocásticas. El modelo se aplica al estudio de la variabilidad temporal de la descarga en un valle aluvial de Tadyikistán, una república independiente del Asia Central.

  13. Optimization of PAM-4 transmitters based on lumped silicon photonic MZMs for high-speed short-reach optical links.

    Science.gov (United States)

    Zhou, Shiyu; Wu, Hsin-Ta; Sadeghipour, Khosrov; Scarcella, Carmelo; Eason, Cormac; Rensing, Marc; Power, Mark J; Antony, Cleitus; O'Brien, Peter; Townsend, Paul D; Ossieur, Peter

    2017-02-20

    We demonstrate how to optimize the performance of PAM-4 transmitters based on lumped Silicon Photonic Mach-Zehnder Modulators (MZMs) for short-reach optical links. Firstly, we analyze the trade-off that occurs between extinction ratio and modulation loss when driving an MZM with a voltage swing less than the MZM's Vπ. This is important when driver circuits are realized in deep submicron CMOS process nodes. Next, a driving scheme based upon a switched capacitor approach is proposed to maximize the achievable bandwidth of the combined lumped MZM and CMOS driver chip. This scheme allows the use of lumped MZM for high speed optical links with reduced RF driver power consumption compared to the conventional approach of driving MZMs (with transmission line based electrodes) with a power amplifier. This is critical for upcoming short-reach link standards such as 400Gb/s 802.3 Ethernet. The driver chip was fabricated using a 65nm CMOS technology and flip-chipped on top of the Silicon Photonic chip (fabricated using IMEC's ISIPP25G technology) that contains the MZM. Open eyes with 4dB extinction ratio for a 36Gb/s (18Gbaud) PAM-4 signal are experimentally demonstrated. The electronic driver chip has a core area of only 0.11mm2 and consumes 236mW from 1.2V and 2.4V supply voltages. This corresponds to an energy efficiency of 6.55pJ/bit including Gray encoder and retiming, or 5.37pJ/bit for the driver circuit only.

  14. SURVIVING OF COMMERCIAL PROBIOTIC STRAIN Lactobacillus rhamnosus GG IN SLOVAK COW LUMP CHEESE EXPERIMENTALLY INOCULATED WITH Listeria innocua

    Directory of Open Access Journals (Sweden)

    Andrea Lauková

    2014-08-01

    Full Text Available Cow lump cheese represents a traditional Slovak cheese. It belongs to fresh types of cheeses. The aim of this study was to test surviving of commercial probiotic strain Lactobacillus rhamnosus GG in cow lump cheese experimentally infected with L. innocua; (listeriae are contaminants and to check the suitability of GG strain as additive for this product. The counts of GG strain in cow lump cheeses were well balanced during whole experiment. It was found in the counts from 5.48 ± 0.15 to 7.77 ±1.50 log10 cfu/g. Its maximum in cheese was 7.77 ± 1.30 log10 cfu/g on day 7 with stability up to day 14. The identity of GG strain isolated from cheeses was confirmed by PCR. The counts of other lactic acid bacteria were also well balanced during the whole experiment in the experimental cheeses with stability up to day 14. Only in E1/GG cheese, the highest number of LAB was detected (10.60 ±1.26 log10 cfu/g. The count of L. innocua LMG 13568 was not influenced. The pH and lactic acid values were not negatively influenced. Visually, the GG cheese provided a good structure (consistency.It can be disputed that shelf-life of the product could be maintained by this way and/or the product itself with GG strain can be consumed as afunctional food or to serve as a probiotic strain carrier.

  15. lumpR 2.0.0: an R package facilitating landscape discretisation for hillslope-based hydrological models

    Science.gov (United States)

    Pilz, Tobias; Francke, Till; Bronstert, Axel

    2017-08-01

    The characteristics of a landscape pose essential factors for hydrological processes. Therefore, an adequate representation of the landscape of a catchment in hydrological models is vital. However, many of such models exist differing, amongst others, in spatial concept and discretisation. The latter constitutes an essential pre-processing step, for which many different algorithms along with numerous software implementations exist. In that context, existing solutions are often model specific, commercial, or depend on commercial back-end software, and allow only a limited or no workflow automation at all. Consequently, a new package for the scientific software and scripting environment R, called lumpR, was developed. lumpR employs an algorithm for hillslope-based landscape discretisation directed to large-scale application via a hierarchical multi-scale approach. The package addresses existing limitations as it is free and open source, easily extendible to other hydrological models, and the workflow can be fully automated. Moreover, it is user-friendly as the direct coupling to a GIS allows for immediate visual inspection and manual adjustment. Sufficient control is furthermore retained via parameter specification and the option to include expert knowledge. Conversely, completely automatic operation also allows for extensive analysis of aspects related to landscape discretisation. In a case study, the application of the package is presented. A sensitivity analysis of the most important discretisation parameters demonstrates its efficient workflow automation. Considering multiple streamflow metrics, the employed model proved reasonably robust to the discretisation parameters. However, parameters determining the sizes of subbasins and hillslopes proved to be more important than the others, including the number of representative hillslopes, the number of attributes employed for the lumping algorithm, and the number of sub-discretisations of the representative hillslopes.

  16. Application of dimensionless sediment rating curves to predict suspended-sediment concentrations, bedload, and annual sediment loads for rivers in Minnesota

    Science.gov (United States)

    Ellison, Christopher A.; Groten, Joel T.; Lorenz, David L.; Koller, Karl S.

    2016-10-27

    Consistent and reliable sediment data are needed by Federal, State, and local government agencies responsible for monitoring water quality, planning river restoration, quantifying sediment budgets, and evaluating the effectiveness of sediment reduction strategies. Heightened concerns about excessive sediment in rivers and the challenge to reduce costs and eliminate data gaps has guided Federal and State interests in pursuing alternative methods for measuring suspended and bedload sediment. Simple and dependable data collection and estimation techniques are needed to generate hydraulic and water-quality information for areas where data are unavailable or difficult to collect.The U.S. Geological Survey, in cooperation with the Minnesota Pollution Control Agency and the Minnesota Department of Natural Resources, completed a study to evaluate the use of dimensionless sediment rating curves (DSRCs) to accurately predict suspended-sediment concentrations (SSCs), bedload, and annual sediment loads for selected rivers and streams in Minnesota based on data collected during 2007 through 2013. This study included the application of DSRC models developed for a small group of streams located in the San Juan River Basin near Pagosa Springs in southwestern Colorado to rivers in Minnesota. Regionally based DSRC models for Minnesota also were developed and compared to DSRC models from Pagosa Springs, Colorado, to evaluate which model provided more accurate predictions of SSCs and bedload in Minnesota.Multiple measures of goodness-of-fit were developed to assess the effectiveness of DSRC models in predicting SSC and bedload for rivers in Minnesota. More than 600 dimensionless ratio values of SSC, bedload, and streamflow were evaluated and delineated according to Pfankuch stream stability categories of “good/fair” and “poor” to develop four Minnesota-based DSRC models. The basis for Pagosa Springs and Minnesota DSRC model effectiveness was founded on measures of goodness

  17. Novel Formulations for Antimicrobial Peptides

    Directory of Open Access Journals (Sweden)

    Ana Maria Carmona-Ribeiro

    2014-10-01

    Full Text Available Peptides in general hold much promise as a major ingredient in novel supramolecular assemblies. They may become essential in vaccine design, antimicrobial chemotherapy, cancer immunotherapy, food preservation, organs transplants, design of novel materials for dentistry, formulations against diabetes and other important strategical applications. This review discusses how novel formulations may improve the therapeutic index of antimicrobial peptides by protecting their activity and improving their bioavailability. The diversity of novel formulations using lipids, liposomes, nanoparticles, polymers, micelles, etc., within the limits of nanotechnology may also provide novel applications going beyond antimicrobial chemotherapy.

  18. Novel Formulations for Antimicrobial Peptides

    Science.gov (United States)

    Carmona-Ribeiro, Ana Maria; Carrasco, Letícia Dias de Melo

    2014-01-01

    Peptides in general hold much promise as a major ingredient in novel supramolecular assemblies. They may become essential in vaccine design, antimicrobial chemotherapy, cancer immunotherapy, food preservation, organs transplants, design of novel materials for dentistry, formulations against diabetes and other important strategical applications. This review discusses how novel formulations may improve the therapeutic index of antimicrobial peptides by protecting their activity and improving their bioavailability. The diversity of novel formulations using lipids, liposomes, nanoparticles, polymers, micelles, etc., within the limits of nanotechnology may also provide novel applications going beyond antimicrobial chemotherapy. PMID:25302615

  19. Physically transparent formulation of a free-electron laser in the linear gain regime

    International Nuclear Information System (INIS)

    Barletta, W.A.; Sessler, A.M.; Yu, L.H.

    1992-08-01

    The recent 2-dimensional analytic theories of a free-electron laser (FEL) in the linear regime are reformulated in terms of three dimensionless ratios that describe the degree to which the characteristics of the electron beam deviate from the cold beam limit of a beam with no emittance or energy spread. In terms of these ratios, algebraic model equations of a fit that combines features of both of the 2-dimensional analyses are given as a convenient computational tool. Graphs of the FEL gain eigenvalue computed with the combined 2-D formulation illustrate that the gain and the output power at saturation are reduced from the 1-D value, when any of the ratios is larger than unity

  20. A lumped parameter method of characteristics approach and multigroup kernels applied to the subgroup self-shielding calculation in MPACT

    Directory of Open Access Journals (Sweden)

    Shane Stimpson

    2017-09-01

    Full Text Available An essential component of the neutron transport solver is the resonance self-shielding calculation used to determine equivalence cross sections. The neutron transport code, MPACT, is currently using the subgroup self-shielding method, in which the method of characteristics (MOC is used to solve purely absorbing fixed-source problems. Recent efforts incorporating multigroup kernels to the MOC solvers in MPACT have reduced runtime by roughly 2×. Applying the same concepts for self-shielding and developing a novel lumped parameter approach to MOC, substantial improvements have also been made to the self-shielding computational efficiency without sacrificing any accuracy. These new multigroup and lumped parameter capabilities have been demonstrated on two test cases: (1 a single lattice with quarter symmetry known as VERA (Virtual Environment for Reactor Applications Progression Problem 2a and (2 a two-dimensional quarter-core slice known as Problem 5a-2D. From these cases, self-shielding computational time was reduced by roughly 3–4×, with a corresponding 15–20% increase in overall memory burden. An azimuthal angle sensitivity study also shows that only half as many angles are needed, yielding an additional speedup of 2×. In total, the improvements yield roughly a 7–8× speedup. Given these performance benefits, these approaches have been adopted as the default in MPACT.

  1. A lumped parameter method of characteristics approach and multigroup kernels applied to the subgroup self-shielding calculation in MPACT

    International Nuclear Information System (INIS)

    Stimpson, Shane G.; Liu, Yuxuan; Collins, Benjamin S.; Clarno, Kevin T.

    2017-01-01

    An essential component of the neutron transport solver is the resonance self-shielding calculation used to determine equivalence cross sections. The neutron transport code, MPACT, is currently using the subgroup self-shielding method, in which the method of characteristics (MOC) is used to solve purely absorbing fixed-source problems. Recent efforts incorporating multigroup kernels to the MOC solvers in MPACT have reduced runtime by roughly 2×. Applying the same concepts for self-shielding and developing a novel lumped parameter approach to MOC, substantial improvements have also been made to the self-shielding computational efficiency without sacrificing any accuracy. These new multigroup and lumped parameter capabilities have been demonstrated on two test cases: (1) a single lattice with quarter symmetry known as VERA (Virtual Environment for Reactor Applications) Progression Problem 2a and (2) a two-dimensional quarter-core slice known as Problem 5a-2D. From these cases, self-shielding computational time was reduced by roughly 3–4×, with a corresponding 15–20% increase in overall memory burden. An azimuthal angle sensitivity study also shows that only half as many angles are needed, yielding an additional speedup of 2×. In total, the improvements yield roughly a 7–8× speedup. Furthermore given these performance benefits, these approaches have been adopted as the default in MPACT.

  2. Neonates need tailored drug formulations.

    Science.gov (United States)

    Allegaert, Karel

    2013-02-08

    Drugs are very strong tools used to improve outcome in neonates. Despite this fact and in contrast to tailored perfusion equipment, incubators or ventilators for neonates, we still commonly use drug formulations initially developed for adults. We would like to make the point that drug formulations given to neonates need to be tailored for this age group. Besides the obvious need to search for active compounds that take the pathophysiology of the newborn into account, this includes the dosage and formulation. The dosage or concentration should facilitate the administration of low amounts and be flexible since clearance is lower in neonates with additional extensive between-individual variability. Formulations need to be tailored for dosage variability in the low ranges and also to the clinical characteristics of neonates. A specific focus of interest during neonatal drug development therefore is a need to quantify and limit excipient exposure based on the available knowledge of their safety or toxicity. Until such tailored vials and formulations become available, compounding practices for drug formulations in neonates should be evaluated to guarantee the correct dosing, product stability and safety.

  3. Microcanonical formulation of quantum field theories

    International Nuclear Information System (INIS)

    Iwazaki, A.

    1984-03-01

    A microcanonical formulation of Euclidean quantum field theories is presented. In the formulation, correlation functions are given by a microcanonical ensemble average of fields. Furthermore, the perturbative equivalence of the formulation and the standard functional formulation is proved and the equipartition low is derived in our formulation. (author)

  4. Tactile friction of topical formulations.

    Science.gov (United States)

    Skedung, L; Buraczewska-Norin, I; Dawood, N; Rutland, M W; Ringstad, L

    2016-02-01

    The tactile perception is essential for all types of topical formulations (cosmetic, pharmaceutical, medical device) and the possibility to predict the sensorial response by using instrumental methods instead of sensory testing would save time and cost at an early stage product development. Here, we report on an instrumental evaluation method using tactile friction measurements to estimate perceptual attributes of topical formulations. Friction was measured between an index finger and an artificial skin substrate after application of formulations using a force sensor. Both model formulations of liquid crystalline phase structures with significantly different tactile properties, as well as commercial pharmaceutical moisturizing creams being more tactile-similar, were investigated. Friction coefficients were calculated as the ratio of the friction force to the applied load. The structures of the model formulations and phase transitions as a result of water evaporation were identified using optical microscopy. The friction device could distinguish friction coefficients between the phase structures, as well as the commercial creams after spreading and absorption into the substrate. In addition, phase transitions resulting in alterations in the feel of the formulations could be detected. A correlation was established between skin hydration and friction coefficient, where hydrated skin gave rise to higher friction. Also a link between skin smoothening and finger friction was established for the commercial moisturizing creams, although further investigations are needed to analyse this and correlations with other sensorial attributes in more detail. The present investigation shows that tactile friction measurements have potential as an alternative or complement in the evaluation of perception of topical formulations. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. Importance of physical examination in early detection of lump in breast in women of different age groups

    International Nuclear Information System (INIS)

    Abbas, H.; Imran, S.; Waris, Noorul-ain-Hafeez; Khanam, A.; Khurshid, R.

    2010-01-01

    Background: The spectrum of breast lesions in adolescents varies markedly from that for adults, with the former lesions being overwhelmingly benign. Fine needle biopsy can be used to distinguish benign and malignant tumour. Study Design: This study examined the characteristics and outcome of women with different age groups in whom physical examination was their sole method of lump in breast detection. Patients and Methods: A total of 200 patients were included in the study. These were divided into 3 groups. Group A was consisting of 75 girls with age of pubescent. Group B included 69 suspected breast cancer women with age range 26-38 years. Fifty-six suspected breast cancer women with age range 41-60 year were included as group C. Study was carried out in patients admitted in the Department/Out-door of Surgery, Sir Ganga Ram Hospital, Lahore, Pakistan. Study period was 6 months. All women received a physical examination by a breast surgeon. Proforma including demographic and clinical characteristics were filled. The diagnosis for patients in this study was achieved by core needle biopsy using a 14-gauge cutting needle. Results: It was observed that early age at menarche ( 25 may be a risk factor in peri/post menopausal women. Active life style is more important with increasing age as it decreases the risk of developing tumour state. Family history was more common in women with peri/post menopausal status as compared to other age groups. Clinical characteristics showed that lump size <2.5 cm was more common in both pubescent and reproductive age. While lump size with a range of 2.5-5.0 cm, was observed in all groups of patients. Fibroadenoma is observed in almost all women with pubescent age while both benign and malignant tumour observed in women with reproductive age. Malignant tumour was observed mostly in women with peri/post menopausal status. Conclusion: Study concluded that early detection or clinical examination with FNA cut out the patients from harassment

  6. airGR: a suite of lumped hydrological models in an R-package

    Science.gov (United States)

    Coron, Laurent; Perrin, Charles; Delaigue, Olivier; Andréassian, Vazken; Thirel, Guillaume

    2016-04-01

    Lumped hydrological models are useful and convenient tools for research, engineering and educational purposes. They propose catchment-scale representations of the precipitation-discharge relationship. Thanks to their limited data requirements, they can be easily implemented and run. With such models, it is possible to simulate a number of hydrological key processes over the catchment with limited structural and parametric complexity, typically evapotranspiration, runoff, underground losses, etc. The Hydrology Group at Irstea (Antony) has been developing a suite of rainfall-runoff models over the past 30 years with the main objectives of designing models as efficient as possible in terms of streamflow simulation, applicable to a wide range of catchments and having low data requirements. This resulted in a suite of models running at different time steps (from hourly to annual) applicable for various issues including water balance estimation, forecasting, simulation of impacts and scenario testing. Recently, Irstea has developed an easy-to-use R-package (R Core Team, 2015), called airGR, to make these models widely available. It includes: - the water balance annual GR1A (Mouehli et al., 2006), - the monthly GR2M (Mouehli, 2003) models, - three versions of the daily model, namely GR4J (Perrin et al., 2003), GR5J (Le Moine, 2008) and GR6J (Pushpalatha et al., 2011), - the hourly GR4H model (Mathevet, 2005), - a degree-day snow module CemaNeige (Valéry et al., 2014). The airGR package has been designed to facilitate the use by non-expert users and allow the addition of evaluation criteria, models or calibration algorithms selected by the end-user. Each model core is coded in FORTRAN to ensure low computational time. The other package functions (i.e. mainly the calibration algorithm and the efficiency criteria) are coded in R. The package is already used for educational purposes. The presentation will detail the main functionalities of the package and present a case

  7. Decontamination formulation with sorbent additive

    Science.gov (United States)

    Tucker; Mark D. , Comstock; Robert H.

    2007-10-16

    A decontamination formulation and method of making that neutralizes the adverse health effects of both chemical and biological compounds, especially chemical warfare (CW) and biological warfare (BW) agents, and toxic industrial chemicals. The formulation provides solubilizing compounds that serve to effectively render the chemical and biological compounds, particularly CW and BW compounds, susceptible to attack, and at least one reactive compound that serves to attack (and detoxify or kill) the compound. The formulation includes at least one solubilizing agent, a reactive compound, a bleaching activator, a sorbent additive, and water. The highly adsorbent, water-soluble sorbent additive (e.g., sorbitol or mannitol) is used to "dry out" one or more liquid ingredients, such as the liquid bleaching activator (e.g., propylene glycol diacetate or glycerol diacetate) and convert the activator into a dry, free-flowing powder that has an extended shelf life, and is more convenient to handle and mix in the field.

  8. A 3D Lumped Thermal Network Model for Long-term Load Profiles Analysis in High Power IGBT Modules

    DEFF Research Database (Denmark)

    Bahman, Amir Sajjad; Ma, Ke; Ghimire, Pramod

    2016-01-01

    )-based simulation is another method which is often used to analyze the steady-state thermal distribution of IGBT modules, but it is not possible to be used for long-term analysis of load profiles of power converter, which is needed for reliability assessments and better thermal design. This paper proposes a novel...... enables both accurate and fast temperature estimation of high power IGBT modules in the real loading conditions of the converter; meanwhile the critical details of the thermal dynamics and thermal distribution are also maintained. The proposed thermal model is verified by both FEM simulation......The conventional RC lumped thermal networks are widely used to estimate the temperature of power devices, but they are lack of accuracy in addressing detailed thermal behaviors/couplings in different locations and layers of the high power IGBT modules. On the other hand, Finite Element (FE...

  9. Stochastic lumping analysis for linear kinetics and its application to the fluctuation relations between hierarchical kinetic networks

    Energy Technology Data Exchange (ETDEWEB)

    Deng, De-Ming; Chang, Cheng-Hung [Institute of Physics, National Chiao Tung University, Hsinchu 300, Taiwan (China)

    2015-05-14

    Conventional studies of biomolecular behaviors rely largely on the construction of kinetic schemes. Since the selection of these networks is not unique, a concern is raised whether and under which conditions hierarchical schemes can reveal the same experimentally measured fluctuating behaviors and unique fluctuation related physical properties. To clarify these questions, we introduce stochasticity into the traditional lumping analysis, generalize it from rate equations to chemical master equations and stochastic differential equations, and extract the fluctuation relations between kinetically and thermodynamically equivalent networks under intrinsic and extrinsic noises. The results provide a theoretical basis for the legitimate use of low-dimensional models in the studies of macromolecular fluctuations and, more generally, for exploring stochastic features in different levels of contracted networks in chemical and biological kinetic systems.

  10. Stochastic lumping analysis for linear kinetics and its application to the fluctuation relations between hierarchical kinetic networks.

    Science.gov (United States)

    Deng, De-Ming; Chang, Cheng-Hung

    2015-05-14

    Conventional studies of biomolecular behaviors rely largely on the construction of kinetic schemes. Since the selection of these networks is not unique, a concern is raised whether and under which conditions hierarchical schemes can reveal the same experimentally measured fluctuating behaviors and unique fluctuation related physical properties. To clarify these questions, we introduce stochasticity into the traditional lumping analysis, generalize it from rate equations to chemical master equations and stochastic differential equations, and extract the fluctuation relations between kinetically and thermodynamically equivalent networks under intrinsic and extrinsic noises. The results provide a theoretical basis for the legitimate use of low-dimensional models in the studies of macromolecular fluctuations and, more generally, for exploring stochastic features in different levels of contracted networks in chemical and biological kinetic systems.

  11. 3D lumped components and miniaturized bandpass filter in an ultra-thin M-LCP for SOP applications

    KAUST Repository

    Arabi, Eyad A.

    2013-01-01

    In this work, a library of 3D lumped components completely embedded in the thinnest, multilayer LCP (M-LCP) stack- up with four metallization layers and 100 μm of total thickness, is reported for the first time. A vertically and horizontally interdigitated capacitor, realized in this stack-up, provides higher self resonant frequency as compared to a similarly sized conventional parallel plate capacitor. Based on the above mentioned library, a miniaturized bandpass filter is presented for the GPS application. It utilizes mutually coupled inductors and is the smallest reported in the literature with a size of (0.035×0.028×0.00089)λg. Finally, the same filter realized in a competing ceramic technology (LTCC) is compared in performance with the ultra-thin M-LCP design. The M-LCP module presented in this work is inherently exible and offers great potential for wearable and conformal applications.

  12. The features of inclined force acting on 1D homogeneous elastic lumped line and corresponding modernisation of the wave equations

    CERN Document Server

    Karavashkin, S B

    2002-01-01

    We analyse the exact analytical solutions for 1D elastic lumped lines under action of an external force inclined to the line axis. We show that in this case an inclined wave being described by an implicit function propagates along the line. We extend this conclusion both to free vibrations and to distributed lines. We prove that the presented solution in the form of implicit function is a generalizing for the wave equation. When taken into consideration exactly, the dynamical processes pattern leads to the conclusion that the divergence of a vector in dynamical fields is not zero but proportional to the scalar product of the partial derivative of the given vector with respect to time into the wave propagation direction vector.

  13. A partial exponential lumped parameter model to evaluate groundwater age distributions and nitrate trends in long-screened wells

    Science.gov (United States)

    Jurgens, Bryant; Böhlke, John Karl; Kauffman, Leon J.; Belitz, Kenneth; Esser, Bradley K.

    2016-01-01

    A partial exponential lumped parameter model (PEM) was derived to determine age distributions and nitrate trends in long-screened production wells. The PEM can simulate age distributions for wells screened over any finite interval of an aquifer that has an exponential distribution of age with depth. The PEM has 3 parameters – the ratio of saturated thickness to the top and bottom of the screen and mean age, but these can be reduced to 1 parameter (mean age) by using well construction information and estimates of the saturated thickness. The PEM was tested with data from 30 production wells in a heterogeneous alluvial fan aquifer in California, USA. Well construction data were used to guide parameterization of a PEM for each well and mean age was calibrated to measured environmental tracer data (3H, 3He, CFC-113, and 14C). Results were compared to age distributions generated for individual wells using advective particle tracking models (PTMs). Age distributions from PTMs were more complex than PEM distributions, but PEMs provided better fits to tracer data, partly because the PTMs did not simulate 14C accurately in wells that captured varying amounts of old groundwater recharged at lower rates prior to groundwater development and irrigation. Nitrate trends were simulated independently of the calibration process and the PEM provided good fits for at least 11 of 24 wells. This work shows that the PEM, and lumped parameter models (LPMs) in general, can often identify critical features of the age distributions in wells that are needed to explain observed tracer data and nonpoint source contaminant trends, even in systems where aquifer heterogeneity and water-use complicate distributions of age. While accurate PTMs are preferable for understanding and predicting aquifer-scale responses to water use and contaminant transport, LPMs can be sensitive to local conditions near individual wells that may be inaccurately represented or missing in an aquifer-scale flow model.

  14. On the time-stepping stability of continuous mass-lumped and discontinuous Galerkin finite elements for the 3D acoustic wave equation

    NARCIS (Netherlands)

    Zhebel, E.; Minisini, S.; Mulder, W.A.

    2012-01-01

    We solve the three-dimensional acoustic wave equation, discretized on tetrahedral meshes. Two methods are considered: mass-lumped continuous finite elements and the symmetric interior-penalty discontinuous Galerkin method (SIP-DG). Combining the spatial discretization with the leap-frog

  15. 41 CFR 301-11.638 - May we offer a lump sum payment to cover the income tax liability on the covered ITRA?

    Science.gov (United States)

    2010-07-01

    ... payment to cover the income tax liability on the covered ITRA? 301-11.638 Section 301-11.638 Public... Thereafter Agency Responsibilities § 301-11.638 May we offer a lump sum payment to cover the income tax... understands that he/she is responsible for any income taxes without further reimbursement. See the...

  16. 41 CFR 301-11.538 - May we offer a lump sum payment to cover the income tax liability on the covered ITRA?

    Science.gov (United States)

    2010-07-01

    ... payment to cover the income tax liability on the covered ITRA? 301-11.538 Section 301-11.538 Public... 1994 Agency Responsibilities § 301-11.538 May we offer a lump sum payment to cover the income tax... understands that he/she is responsible for any income taxes without further reimbursement. (See the...

  17. Foreign body granuloma in the anterior abdominal wall mimicking an acute appendicular lump and induced by a translocated copper-T intrauterine contraceptive device: a case report

    Directory of Open Access Journals (Sweden)

    Ansari Maulana Mohammed

    2009-04-01

    Full Text Available Abstract Introduction Intrauterine contraceptive devices may at times perforate and migrate to adjacent organs. Such uterine perforation usually passes unnoticed with development of potentially serious complications. Case presentation A 25-year-old woman of North Indian origin presented with an acute tender lump in the right iliac fossa. The lump was initially thought to be an appendicular lump and treated conservatively. Resolution of the lump was incomplete. On exploratory laparotomy, a hard suspicious mass was found in the anterior abdominal wall of the right iliac fossa. Wide excision and bisection of the mass revealed a copper-T embedded inside. Examination of the uterus did not show any evidence of perforation. The next day, the patient gave a history of past copper-T Intrauterine contraceptive device insertion. Conclusions Copper-T insertion is one of the simplest contraceptive methods but its neglect with inadequate follow-up may lead to uterine perforation and extra-uterine migration. Regular self-examination for the "threads" supplemented with abdominal X-ray and/or ultrasound in the follow-up may detect copper-T migration early. To the best of our knowledge, this is the first report of intrauterine contraceptive device migration to the anterior abdominal wall of the right iliac fossa.

  18. Optimal Compensation with Hidden Action and Lump-Sum Payment in a Continuous-Time Model

    International Nuclear Information System (INIS)

    Cvitanic, Jaksa; Wan, Xuhu; Zhang Jianfeng

    2009-01-01

    We consider a problem of finding optimal contracts in continuous time, when the agent's actions are unobservable by the principal, who pays the agent with a one-time payoff at the end of the contract. We fully solve the case of quadratic cost and separable utility, for general utility functions. The optimal contract is, in general, a nonlinear function of the final outcome only, while in the previously solved cases, for exponential and linear utility functions, the optimal contract is linear in the final output value. In a specific example we compute, the first-best principal's utility is infinite, while it becomes finite with hidden action, which is increasing in value of the output. In the second part of the paper we formulate a general mathematical theory for the problem. We apply the stochastic maximum principle to give necessary conditions for optimal contracts. Sufficient conditions are hard to establish, but we suggest a way to check sufficiency using non-convex optimization

  19. Curcumin nanodisks: formulation and characterization

    OpenAIRE

    Ghosh, Mistuni; Singh, Amareshwar T. K.; Xu, Wenwei; Sulchek, Todd; Gordon, Leo I.; Ryan, Robert O.

    2010-01-01

    Nanodisks (ND) are nanoscale, disk-shaped phospholipid bilayers whose edge is stabilized by apolipoproteins. In the present study, ND were formulated with the bioactive polyphenol, curcumin, at a 6:1 phospholipid:curcumin molar ratio. Atomic force microscopy revealed that curcumin-ND are particles with diameters

  20. Covariant Formulation of Hooke's Law.

    Science.gov (United States)

    Gron, O.

    1981-01-01

    Introducing a four-vector strain and a four-force stress, Hooke's law is written as a four-vector equation. This formulation is shown to clarify seemingly paradoxical results in connection with uniformly accelerated motion, and rotational motion with angular acceleration. (Author/JN)

  1. Hamiltonian formulation of the supermembrane

    International Nuclear Information System (INIS)

    Bergshoeff, E.; Sezgin, E.; Tanii, Y.

    1987-06-01

    The Hamiltonian formulation of the supermembrane theory in eleven dimensions is given. The covariant split of the first and second class constraints is exhibited, and their Dirac brackets are computed. Gauge conditions are imposed in such a way that the reparametrizations of the membrane with divergence free 2-vectors are unfixed. (author). 10 refs

  2. A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens

    Science.gov (United States)

    Wu, Jun Jie; Wu, Weiju; Tholozan, Frederique M.; Saunter, Christopher D.; Girkin, John M.; Quinlan, Roy A.

    2015-01-01

    We present a mathematical (ordered pull-through; OPT) model of the cell-density profile for the mammalian lens epithelium together with new experimental data. The model is based upon dimensionless parameters, an important criterion for inter-species comparisons where lens sizes can vary greatly (e.g. bovine (approx. 18 mm); mouse (approx. 2 mm)) and confirms that mammalian lenses scale with size. The validated model includes two parameters: β/α, which is the ratio of the proliferation rate in the peripheral and in the central region of the lens; and γGZ, a dimensionless pull-through parameter that accounts for the cell transition and exit from the epithelium into the lens body. Best-fit values were determined for mouse, rat, rabbit, bovine and human lens epithelia. The OPT model accounts for the peak in cell density at the periphery of the lens epithelium, a region where cell proliferation is concentrated and reaches a maximum coincident with the germinative zone. The β/α ratio correlates with the measured FGF-2 gradient, a morphogen critical to lens cell survival, proliferation and differentiation. As proliferation declines with age, the OPT model predicted age-dependent changes in cell-density profiles, which we observed in mouse and human lenses. PMID:26236824

  3. Irreversibility analysis of non isothermal flat plate solar collectors for air heating with a dimensionless model; Analisis de las irreversibilidades en colectores solares de placas planas no isotermicos para calentamiento de aire utilizando un modelo adimensional

    Energy Technology Data Exchange (ETDEWEB)

    Bracamonte-Baran, Johane Hans; Baritto-Loreto, Miguel Leonardo [Universidad Central de Venezuela (Venezuela)]. E-mails: johanehb@gmail.com; johane.bracamonte@ucv.ve; miguel.baritto@ucv.ve

    2013-04-15

    The dimensionless model developed and validated by Baritto and Bracamonte (2012) for the thermal behavior of flat plate solar collector without glass cover is improved by adding the entropy balance equation in a dimensionless form. The model is solved for a wide range of aspect ratios and mass flow numbers. A parametric study is developed and the distribution of internal irreversibilities along the collector is analyzed. The influence of the design parameters on the entropy generation by fluid friction and heat transfer is analyzed and it is found that for certain combinations of these parameters optimal thermodynamic operation can be achieved. [Spanish] En el presente trabajo, el modelo adimensional desarrollado y validado por Baritto y Bracamonte (2012) para describir el comportamiento termico de colectores solares de placas planas sin cubierta transparente, se complementa con la ecuacion adimensional de balance de entropia para un elemento diferencial de colector solar. El modelo se resuelve para un amplio rango de valores de relaciones de aspecto y numero de flujo de masa. A partir de los resultados del modelo se desarrolla un analisis detallado de la influencia de estos parametros sobre la distribucion de irreversibilidades internas a lo largo del colector. Adicionalmente se estudia la influencia de estos parametros sobre los numeros de generacion de entropia por friccion viscosa, por transferencia de calor y total. Se encuentra que existen combinaciones de los parametros antes mencionados, para los cuales, la operacion del colector es termodinamicamente optima para numeros de flujo de masa elevados.

  4. Assessment of hydrogen risk using advanced methodology for lumped parameter code-MELCOR

    International Nuclear Information System (INIS)

    Duspiva, Jiri; Kujal, Bohumir

    2007-01-01

    The hydrogen risk is one of the most important containment integrity challenge during a severe accident progression at the VVER type reactors installed at the Czech NPPs. On the basis of recent comprehensive research results the general flame acceleration (FA) and deflagration-to-detonation transition (DDT) criteria were formulated. The main objective of the new methodology developed in the NRI Rez was to prepare an analytical tool for the assessment of the hydrogen risk at the Czech NPPs in the course of a severe accident and also for the design of hydrogen removal system which should be able to prevent or at least minimize the threats of hydrogen detonation in containments. The major idea on which the development of models for the FA and DDT criteria was based is described in OECD state-of-art report (NEA, 2000). The module for the computation of FA criterion (often named σ-criterion) and DDT one (also named λ or Dorofeev criterion) was linked to the MELCOR 1.8.5 model of VVER-1000 containment. The most important feature of new model is that it makes possible to evaluate the both of the criteria for all compartments in the containment continuously during severe accident scenario progression. The containment model, which could be used for such a calculation, has to be very detailed owing to appropriate description of hydrogen distribution. New model was tested by calculation of hydrogen detonation risk in the VVER-1000 containment during severe accident scenario initiated by medium break LOCA. At present two more VVER-1000 severe accident scenarios have been analyzed. The mapping of a hydrogen detonation risk in individual compartments inside containment was performed. The results of analysis confirm that the risk of hydrogen detonation in the great majority of containment compartments during severe accidents is very high if the hydrogen removal system is not installed. (author)

  5. Langevin formulation of quantum dynamics

    International Nuclear Information System (INIS)

    Roncadelli, M.

    1989-03-01

    We first show that nonrelativistic quantum mechanics formulated at imaginary-(h/2 π) can formally be viewed as the Fokker-Planck description of a frictionless brownian motion, which occurs (in general) in an absorbing medium. We next offer a new formulation of quantum mechanics, which is basically the Langevin treatment of this brownian motion. Explicitly, we derive a noise-average representation for the transition probability W(X'',t''|X',t'), in terms of the solutions to a Langevin equation with a Gaussian white-noise. Upon analytic continuation back to real-(h/2 π),W(X'',t''|X',t') becomes the propagator of the original Schroedinger equation. Our approach allows for a straightforward application to quantum dynamical problems of the mathematical techniques of classical stochastic processes. Moreover, computer simulations of quantum mechanical systems can be carried out by using numerical programs based on the Langevin dynamics. (author). 19 refs, 1 tab

  6. Optimization of chlorphenesin emulgel formulation

    OpenAIRE

    Mohamed, Magdy I.

    2004-01-01

    This study was conducted to develop an emulgel formulation of chlorphenesin (CHL) using 2 types of gelling agents: hydroxypropylmethyl cellulose (HPMC) and Carbopol 934. The influence of the type of the gelling agent and the concentration of both the oil phase and emulsifying agent on the drug release from the prepared emulgels was investigated using a 23 factorial design. The prepared emulgels were evaluated for their physical appearance, rheological behavior, drug release, antifungal activi...

  7. Comparison of Lumped and Distributed Hydrologic Models Used for Planning and Water Resources Management at the Combeima River Basin, Colombia.

    Science.gov (United States)

    Salgado, F., II; Vélez, J.

    2014-12-01

    The catchment area is considered as the planning unit of natural resources where multiple factors as biotic, abiotic and human interact in a web of relationships making this unit a complex system. It is also considered by several authors as the most suitable unit for studying the water movement in nature and a tool for the understanding of natural processes. This research implements several hydrological models commonly used in water resources management and planning. It is the case of Témez, abcd, T, P, ARMA (1,1), and the lumped conceptual model TETIS. This latest model has been implemented in its distributed version for comparison purposes and it has been the basis for obtaining information, either through the reconstruction of natural flow series, filling missing data, forecasting or simulation. Hydrological models make use of lumped data of precipitation and potential evapotranspiration, as well as the following parameters for each one of the models which are related to soil properties as capillary storage capacity; the hydraulic saturated conductivity of the upper and lower layers of the soil, and residence times in the flow surface, subsurface layers and base flow. The calibration and the validation process of the models were performed making adjustments to the parameters listed above, taking into account the consistency in the efficiency indexes and the adjustment between the observed and simulated flows using the flow duration curve. The Nash index gave good results for the TETIS model and acceptable values were obtained to the other models. The calibration of the distributed model was complex and its results were similar to those obtained with the aggregated model. This comparison allows planners to use the hydrological multimodel techniques to reduce the uncertainty associated with planning processes in developing countries. Moreover, taking into account the information limitations required to implement a hydrological models, this application can be a

  8. A calibration-free formulation of the complementary relationship of evaporation for continental-scale hydrology

    Science.gov (United States)

    Szilagyi, Jozsef; Crago, Richard; Qualls, Russell

    2017-01-01

    An important scaling consideration is introduced into the formulation of the complementary relationship (CR) of land surface evapotranspiration (ET) by specifying the maximum possible evaporation rate (Epmax) of a small water body (or wet patch) as a result of adiabatic drying from the prevailing near-neutral atmospheric conditions. In dimensionless form the CR therefore becomes yB = f(Epmax-EpEpmax-EwxB) = f(X) = 2X2 - X3, where yB = ET/Ep, xB = Ew/Ep. Ew is the wet-environment evaporation rate as given by the Priestley-Taylor equation, Ep is the evaporation rate of the same small wet surface for which Epmax is specified and estimated by the Penman equation. With the help of North American Regional Reanalysis data, the CR this way yields better continental-scale performance than earlier, calibrated versions of it and is on par with current land surface model results, the latter requiring vegetation, soil information and soil moisture bookkeeping. Validation has been performed by Parameter-Elevation Regressions on Independent Slopes Model precipitation and United States Geological Survey runoff data. A novel approach is also introduced to calculate the value of the Priestley-Taylor parameter to be used with continental-scale data, making the new formulation of the CR completely calibration free.

  9. Measurement of Hydrologic Streamflow Metrics and Estimation of Streamflow with Lumped Parameter Models in a Managed Lake System, Sebago Lake, Maine

    Science.gov (United States)

    Reeve, A. S.; Martin, D.; Smith, S. M.

    2013-12-01

    Surface waters within the Sebago Lake watershed (southern Maine, USA) provide a variety of economically and intrinsically valuable recreational, commercial and environmental services. Different stakeholder groups for the 118 km2 Sebago Lake and surrounding watershed advocate for different lake and watershed management strategies, focusing on the operation of a dam at the outflow from Sebago Lake. While lake level in Sebago Lake has been monitored for over a century, limited data is available on the hydrologic processes that drive lake level and therefore impact how dam operation (and other changes to the region) will influence the hydroperiod of the lake. To fill this information gap several tasks were undertaken including: 1) deploying data logging pressure transducers to continuously monitor stream stage in nine tributaries, 2) measuring stream discharge at these sites to create rating curves for the nine tributaries, and using the resulting continuous discharge records to 3) calibrate lumped parameter computer models based on the GR4J model, modified to include a degree-day snowmelt routine. These lumped parameter models have been integrated with a simple lake water-balance model to estimate lake level and its response to different scenarios including dam management strategies. To date, about three years of stream stage data have been used to estimate stream discharge in all monitored tributaries (data collection is ongoing). Baseflow separation indices (BFI) for 2010 and 2011 using the USGS software PART and the Eckhart digital filter in WHAT range from 0.80-0.86 in the Crooked River and Richmill Outlet,followed by Northwest (0.75) and Muddy (0.53-0.56) Rivers, with the lowest BFI measured in Sticky River (0.41-0.56). The BFI values indicate most streams have significant groundwater (or other storage) inputs. The lumped parameter watershed model has been calibrated for four streams (Nash-Sutcliffe = 0.4 to 0.9), with the other major tributaries containing

  10. A 3D Dynamic Lumped Parameter Thermal Network of Air-Cooled YASA Axial Flux Permanent Magnet Synchronous Machine

    Directory of Open Access Journals (Sweden)

    Abdalla Hussein Mohamed

    2018-03-01

    Full Text Available To find the temperature rise for high power density yokeless and segmented armature (YASA axial flux permanent magnet synchronous (AFPMSM machines quickly and accurately, a 3D lumped parameter thermal model is developed and validated experimentally and by finite element (FE simulations on a 4 kW YASA machine. Additionally, to get insight in the thermal transient response of the machine, the model accounts for the thermal capacitance of different machine components. The model considers the stator, bearing, and windage losses, as well as eddy current losses in the magnets on the rotors. The new contribution of this work is that the thermal model takes cooling via air channels between the magnets on the rotor discs into account. The model is parametrized with respect to the permanent magnet (PM angle ratio, the PM thickness ratio, the air gap length, and the rotor speed. The effect of the channels is incorporated via convection equations based on many computational fluid dynamics (CFD computations. The model accuracy is validated at different values of parameters by FE simulations in both transient and steady state. The model takes less than 1 s to solve for the temperature distribution.

  11. From Streams to Lumps: Transforming Long-Term Incentives into Up-Front Financing for New Nuclear Construction

    International Nuclear Information System (INIS)

    George, Glenn R.

    2006-01-01

    The Energy Policy Act of 2005 is an important development in the financing of new nuclear capacity in the near- to mid-term in the U.S.A. Key features of the Act, including production tax credits, loan guarantees, funding support, and 'standby support', are intended to provide significant incentives for new nuclear development, construction, and operation. There is a mismatch, however, between the nature and extent of incentives being offered and what is needed to spur nuclear plant deployment in light of power market uncertainty, utility investor wariness, and the need to raise significant capital before a nuclear construction project can be launched. In this paper, the author addresses these issues through the lens of financial tools and techniques. The paper considers various ways in which long-term streams of subsidies can be transformed into up-front financing for new nuclear capacity. Securing and related financial structures are among the mechanisms considered for potentially bridging the temporal gap between flows of financial benefits conferred legislatively and lumps of capital required by developers and investors in advance of a construction program. (authors)

  12. MISTRA facility for containment lumped parameter and CFD codes validation. Example of the International Standard Problem ISP47

    International Nuclear Information System (INIS)

    Tkatschenko, I.; Studer, E.; Paillere, H.

    2005-01-01

    During a severe accident in a Pressurized Water Reactor (PWR), the formation of a combustible gas mixture in the complex geometry of the reactor depends on the understanding of hydrogen production, the complex 3D thermal-hydraulics flow due to gas/steam injection, natural convection, heat transfer by condensation on walls and effect of mitigation devices. Numerical simulation of such flows may be performed either by Lumped Parameter (LP) or by Computational Fluid Dynamics (CFD) codes. Advantages and drawbacks of LP and CFD codes are well-known. LP codes are mainly developed for full size containment analysis but they need improvements, especially since they are not able to accurately predict the local gas mixing within the containment. CFD codes require a process of validation on well-instrumented experimental data before they can be used with a high degree of confidence. The MISTRA coupled effect test facility has been built at CEA to fulfil this validation objective: with numerous measurement points in the gaseous volume - temperature, gas concentration, velocity and turbulence - and with well controlled boundary conditions. As illustration of both experimental and simulation areas of this topic, a recent example in the use of MISTRA test data is presented for the case of the International Standard Problem ISP47. The proposed experimental work in the MISTRA facility provides essential data to fill the gaps in the modelling/validation of computational tools. (author)

  13. Valuing Ecosystem Services with Fishery Rents: A Lumped-Parameter Approach to Hypoxia in the Neuse River Estuary

    Directory of Open Access Journals (Sweden)

    Larry B. Crowder

    2011-11-01

    Full Text Available Valuing ecosystem services with microeconomic underpinnings presents challenges because these services typically constitute nonmarket values and contribute to human welfare indirectly through a series of ecological pathways that are dynamic, nonlinear, and difficult to quantify and link to appropriate economic spatial and temporal scales. This paper develops and demonstrates a method to value a portion of ecosystem services when a commercial fishery is dependent on the quality of estuarine habitat. Using a lumped-parameter, dynamic open access bioeconomic model that is spatially explicit and includes predator-prey interactions, this paper quantifies part of the value of improved ecosystem function in the Neuse River Estuary when nutrient pollution is reduced. Specifically, it traces the effects of nitrogen loading on the North Carolina commercial blue crab fishery by modeling the response of primary production and the subsequent impact on hypoxia (low dissolved oxygen. Hypoxia, in turn, affects blue crabs and their preferred prey. The discounted present value fishery rent increase from a 30% reduction in nitrogen loadings in the Neuse is $2.56 million, though this welfare estimate is fairly sensitive to some parameter values. Surprisingly, this number is not sensitive to initial conditions.

  14. A new analytical method for estimating lumped parameter constants of linear viscoelastic models from strain rate tests

    Science.gov (United States)

    Mattei, G.; Ahluwalia, A.

    2018-04-01

    We introduce a new function, the apparent elastic modulus strain-rate spectrum, E_{app} ( \\dot{ɛ} ), for the derivation of lumped parameter constants for Generalized Maxwell (GM) linear viscoelastic models from stress-strain data obtained at various compressive strain rates ( \\dot{ɛ}). The E_{app} ( \\dot{ɛ} ) function was derived using the tangent modulus function obtained from the GM model stress-strain response to a constant \\dot{ɛ} input. Material viscoelastic parameters can be rapidly derived by fitting experimental E_{app} data obtained at different strain rates to the E_{app} ( \\dot{ɛ} ) function. This single-curve fitting returns similar viscoelastic constants as the original epsilon dot method based on a multi-curve global fitting procedure with shared parameters. Its low computational cost permits quick and robust identification of viscoelastic constants even when a large number of strain rates or replicates per strain rate are considered. This method is particularly suited for the analysis of bulk compression and nano-indentation data of soft (bio)materials.

  15. Perfume formulation: words and chats.

    Science.gov (United States)

    Ellena, Céline

    2008-06-01

    What does it mean to create fragrances with materials from chemistry and/or from nature? How are they used to display their characteristic differences, their own personality? Is it easier to create with synthetic raw materials or with essential oils? This review explains why a perfume formulation corresponds in fact to a conversation, an interplay between synthetic and natural perfumery materials. A synthetic raw material carries a single information, and usually is very linear. Its smell is uniform, clear, and faithful. Natural raw materials, on the contrary, provide a strong, complex and generous image. While a synthetic material can be seen as a single word, a natural one such as rose oil could be compared to chatting: cold, warm, sticky, heavy, transparent, pepper, green, metallic, smooth, watery, fruity... full of information. Yet, if a very small amount of the natural material is used, nothing happens, the fragrance will not change. However, if a large amount is used, the rose oil will swallow up everything else. The fragrance will smell of nothing else except rose! To formulate a perfume is not to create a culinary recipe, with only dosing the ingredients in well-balanced amounts. To formulate rather means to flexibly knit materials together with a lively stitch, meeting or repelling each other, building a pleasant form, which is neither fixed, nor solid, nor rigid. A fragrance has an overall structure, which ranges from a clear sound, made up of stable, unique, and linear items, to a background chat, comfortable and reassuring. But that does, of course, not mean that there is only one way of creating a fragrance!

  16. Formulation of soy oil products

    Directory of Open Access Journals (Sweden)

    Woerfel, John B.

    1995-12-01

    Full Text Available The paper comments different formulations of soy oil products such as salad and cooking oils, margarine, shortenings, commercial shortenings, frying shortenings, and fluid shortenings. Hydrogenation and its influence on final products is also included.

    El trabajo presenta diferentes formulaciones a base de aceite de soja tales como aceites para ensalada y cocinado, margarina, grasas sólidas (shortenings, grasas sólidas comerciales, grasas sólidas para frituras y grasas fluidas. Hace también referencia al proceso de hidrogenación y a sus efectos en los productos finales.

  17. Formulation and Characterization of Sustained Release Floating ...

    African Journals Online (AJOL)

    Purpose: To formulate sustained release gastroretentive microballoons of metformin hydrochloride with the objective of improving its bioavailability. Methods: Microballoons of metformin hydrochloride were formulated by solvent evaporation and diffusion method using varying mixtures of hydroxypropyl methylcellulose ...

  18. Bioequivalence assessment of two formulations of ibuprofen

    KAUST Repository

    Al-Talla, Zeyad; Akrawi, Sabah H; Tolley, Luke T; Sioud, Salim H; Zaater, Mohammed F; Emwas, Abdul-Hamid M

    2011-01-01

    Background: This study assessed the relative bioavailability of two formulations of ibuprofen. The first formulation was Doloraz , produced by Al-Razi Pharmaceutical Company, Amman, Jordan. The second forumulation was Brufen , manufactured by Boots

  19. Modern approach to relativity theory (radar formulation)

    International Nuclear Information System (INIS)

    Strel'tsov, V.N.

    1991-01-01

    The main peculiarities of the radar formulation of the relativity theory are presented. This formulation operates with the retarded (light) distances and relativistic or radar length introduced on their basis. 21 refs.; 1 tab

  20. A general contact mechanical formulation of multilayered structures and its application to deconvolute thickness/mechanical properties of glue used in surface force apparatus.

    Science.gov (United States)

    Math, Souvik; Horn, Roger; Jayaram, Vikram; Biswas, Sanjay Kumar

    2007-04-15

    Currently data obtained from surface force apparatus experiments are convoluted with the mechanical response of glue of unknown thickness, used to bond mica sheets to the substrates. This paper describes a formulation to precisely deconvolute out the forces between the mica sheets by determining the thickness of glue, knowing the mechanical properties of the glue. The formulation consists of a general solution based on the noniterative Hankel transform of the Laplace equation. The generality is achieved by treating all the layers except the one in contact as an effective lumped system consisting of a set of springs in series, where each spring represents a layer. The solution is validated by nanoindentation of trilayer systems consisting of layers with widely diverse mechanical properties, some differing from each other by three orders of magnitude. SFA experiments are done with carefully metered slabs of glue. The proposed method is validated by comparing the actual glue thicknesses with those determined using the present analysis.

  1. Formulation, Preparation, and Characterization of Polyurethane Foams

    Science.gov (United States)

    Pinto, Moises L.

    2010-01-01

    Preparation of laboratory-scale polyurethane foams is described with formulations that are easy to implement in experiments for undergraduate students. Particular attention is given to formulation aspects that are based on the main chemical reactions occurring in polyurethane production. This allows students to develop alternative formulations to…

  2. Performance Evaluation of Abrasive Grinding Wheel Formulated ...

    African Journals Online (AJOL)

    This paper presents a study on the formulation and manufacture of abrasive grinding wheel using locally formulated silicon carbide abrasive grains. Six local raw material substitutes were identified through pilot study and with the initial mix of the identified materials, a systematic search for an optimal formulation of silicon ...

  3. Optimization of chlorphenesin emulgel formulation.

    Science.gov (United States)

    Mohamed, Magdy I

    2004-10-11

    This study was conducted to develop an emulgel formulation of chlorphenesin (CHL) using 2 types of gelling agents: hydroxypropylmethyl cellulose (HPMC) and Carbopol 934. The influence of the type of the gelling agent and the concentration of both the oil phase and emulsifying agent on the drug release from the prepared emulgels was investigated using a 2(3) factorial design. The prepared emulgels were evaluated for their physical appearance, rheological behavior, drug release, antifungal activity, and stability. Commercially available CHL topical powder was used for comparison. All the prepared emulgels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. They also exhibited higher drug release and antifungal activity than the CHL powder. It was found that the emulsifying agent concentration had the most pronounced effect on the drug release from the emulgels followed by the oil phase concentration and finally the type of the gelling agent. The drug release from all the emulgels was found to follow diffusion-controlled mechanism. Rheological studies revealed that the CHL emulgels exhibited a shear-thinning behavior with thixotropy. Stability studies showed that the physical appearance, rheological properties, drug release, and antifungal activity in all the prepared emulgels remained unchanged upon storage for 3 months. As a general conclusion, it was suggested that the CHL emulgel formulation prepared with HPMC with the oil phase concentration in its low level and emulsifying agent concentration in its high level was the formula of choice since it showed the highest drug release and antifungal activity.

  4. Multi-time-step ahead daily and hourly intermittent reservoir inflow prediction by artificial intelligent techniques using lumped and distributed data

    Science.gov (United States)

    Jothiprakash, V.; Magar, R. B.

    2012-07-01

    SummaryIn this study, artificial intelligent (AI) techniques such as artificial neural network (ANN), Adaptive neuro-fuzzy inference system (ANFIS) and Linear genetic programming (LGP) are used to predict daily and hourly multi-time-step ahead intermittent reservoir inflow. To illustrate the applicability of AI techniques, intermittent Koyna river watershed in Maharashtra, India is chosen as a case study. Based on the observed daily and hourly rainfall and reservoir inflow various types of time-series, cause-effect and combined models are developed with lumped and distributed input data. Further, the model performance was evaluated using various performance criteria. From the results, it is found that the performances of LGP models are found to be superior to ANN and ANFIS models especially in predicting the peak inflows for both daily and hourly time-step. A detailed comparison of the overall performance indicated that the combined input model (combination of rainfall and inflow) performed better in both lumped and distributed input data modelling. It was observed that the lumped input data models performed slightly better because; apart from reducing the noise in the data, the better techniques and their training approach, appropriate selection of network architecture, required inputs, and also training-testing ratios of the data set. The slight poor performance of distributed data is due to large variations and lesser number of observed values.

  5. Cytological and Pathological Correlation of FNAC in Assessing Breast Lumps and Axillary Lymph Node Swellings in a Public Sector Hospital in India

    Directory of Open Access Journals (Sweden)

    Vasu Reddy Challa

    2013-01-01

    Full Text Available Background. Breast lumps have varied pathology, and there are different techniques to prove the diagnosis. The aim of the present study is to analyze the role of fine needle aspiration cytology (FNAC of the breast lesions at our center. Methods. We had retrospectively analysed 854 patients who underwent FNAC for primary breast lumps and 190 patients who underwent FNAC for an axillary lymph node in the year 2010. Results. Of 854 patients, histological correlation was available in 723 patients. The analysis was done for 812 patients as medical records were not available for 42 patients. FNAC was false negative in seven cases; 2 cases of phyllodes were reported as fibroadenoma, and 5 cases of carcinoma were diagnosed as atypical hyperplasia. The sensitivity, specificity, and false negative value of FNAC in diagnosing breast lumps were 99% (715/723, 100%, and 1%, respectively. Of 190 patients for whom FNAC was performed for axilla, 170 had proven to have axillary lymph node metastases, and the rest had reactive hyperplasia or inflammatory cells. Conclusions. FNAC is rapid, accurate, outpatient based, and less complicated procedure and helps in diagnosis of breast cancer, benign diseases, and axillary involvement in experienced hands with less chance of false results.

  6. Formulation development for PREPP concreted waste forms

    International Nuclear Information System (INIS)

    Neilson, R.M. Jr.; Welch, J.M.

    1984-05-01

    Analysis of variance and logistic regression techniques have been used to develop models describing the effects of formulation variables and their interactions on compressive strength, solidification, free-standing water, and workability of hydraulic cement grouts incorporating simulated Process Experimental Pilot Plant (PREPP) wastes. These models provide the basis for specifications of grout formulations to solidify these wastes. The experimental test matrix, formulation preparation, and test methods employed are described. The development of analytical models for formulation behavior and the conclusions drawn regarding appropriate formulation variable ranges are discussed. 13 references, 9 figures, 15 tables

  7. Using lumped modelling for providing simple metrics and associated uncertainties of catchment response to agricultural-derived nitrates pollutions

    Science.gov (United States)

    RUIZ, L.; Fovet, O.; Faucheux, M.; Molenat, J.; Sekhar, M.; Aquilina, L.; Gascuel-odoux, C.

    2013-12-01

    The development of simple and easily accessible metrics is required for characterizing and comparing catchment response to external forcings (climate or anthropogenic) and for managing water resources. The hydrological and geochemical signatures in the stream represent the integration of the various processes controlling this response. The complexity of these signatures over several time scales from sub-daily to several decades [Kirchner et al., 2001] makes their deconvolution very difficult. A large range of modeling approaches intent to represent this complexity by accounting for the spatial and/or temporal variability of the processes involved. However, simple metrics are not easily retrieved from these approaches, mostly because of over-parametrization issues. We hypothesize that to obtain relevant metrics, we need to use models that are able to simulate the observed variability of river signatures at different time scales, while being as parsimonious as possible. The lumped model ETNA (modified from[Ruiz et al., 2002]) is able to simulate adequately the seasonal and inter-annual patterns of stream NO3 concentration. Shallow groundwater is represented by two linear stores with double porosity and riparian processes are represented by a constant nitrogen removal function. Our objective was to identify simple metrics of catchment response by calibrating this lumped model on two paired agricultural catchments where both N inputs and outputs were monitored for a period of 20 years. These catchments, belonging to ORE AgrHys, although underlain by the same granitic bedrock are displaying contrasted chemical signatures. The model was able to simulate the two contrasted observed patterns in stream and groundwater, both on hydrology and chemistry, and at the seasonal and pluri-annual scales. It was also compatible with the expected trends of nitrate concentration since 1960. The output variables of the model were used to compute the nitrate residence time in both the

  8. Energy policy formulation for Pakistan

    International Nuclear Information System (INIS)

    Riaz, T.

    1981-01-01

    Pakistan is a low income, low energy consumption country. In view of the close interdependence between economic growth and energy consumption, she will need increasing energy supplies in order to maintain her economic growth. This paper develops an energy sector optimization model for the Pakistan economy, which consists of production models for five energy industries, ie oil, gas, coal, electricity (including electricity generated in nuclear power plants) and non-commercial fuels. The model is first used to forecast energy balances for the period 1975 - 2006. The model is then employed to formulate a long-term comprehensive energy policy for Pakistan. Finally the suggested policy is compared with the current official energy programme. (author)

  9. On Scalar Energy: Mathematical Formulation

    International Nuclear Information System (INIS)

    Hathout, A.M.

    2011-01-01

    A new kind of electromagnetic waves (EMW), which exists only in vacuum of the empty space, will be discussed and mathematically formulated in this paper. The mathematical existence of this energy was first proposed in a series of groundbreaking equations by Scottish Mathematician, James Clerk Maxwell, in the mid of 1800 and 39;s. This energy is called scalar energy. It is characterized by both particle and wave like. The waves of this energy are called longitudinal EMW to distinguish them from transverse EM, the kind we are familiar with in our daily life. Teslas name of this energy is scalar energy or zero point energy. It is aimed at this paper to explain more details and to verify the scalar EM concept in vacuum.

  10. Layered storage of biogenic methane-enriched gas bubbles in peat: A lumped capacitance model controlled by soil structure

    Science.gov (United States)

    Chen, X.; Comas, X.; Binley, A. M.; Slater, L. D.

    2017-12-01

    Methane can accumulate in the gaseous phase in peats, and enter the atmosphere as gas bubbles with a mass flux higher than that via diffusion and plant-mediated pathways. A complete understanding of the mechanisms regulating bubble storage in peats remains incomplete. We developed a layered model to quantify the storage of gas bubbles over a peat column based on a general lumped capacitance model. This conceptual model was applied to explain the effects of peat structure on bubble storage at different depths observed in a laboratory experiment. A peat monolith was collected from the Everglades, a subtropical wetland located in Florida (USA), and kept submerged in a cuboid chamber over 102 days until gas bubble saturation was achieved. Time-lapse ground-penetrating radar (GPR) was used to estimate changes in gas content of each layer and the corresponding average dimensions of stored gas bubbles. The results highlight a hotspot layer of bubble accumulation at depths between 5 and 10 cm below the monolith surface. Bubbles in this shallow hotspot layer were larger relative to those in deeper layers, whilst the degree of decomposition of the upper layers was generally smaller than that of the lower layers based on von Post humification tests. X-ray Computer tomography (CT) was applied to resin-impregnated peat sections from different depths and the results showed that a higher porosity promotes bubbles storage. The stored gas bubbles were released by changing water levels and the air CH4 concentrations above the peat monolith were measured using a flow-through chamber system to confirm the high CH4 concentration in the stored bubbles. Our findings suggest that bubble capacitance is related to the difference in size between gas bubbles and peat pores. This work has implications for better understanding how changes in water table elevation associated with climate change and sea level rise (particularly for freshwater wetlands near coastal areas like the Everglades) may

  11. Spiking Neural Classifier with Lumped Dendritic Nonlinearity and Binary Synapses: A Current Mode VLSI Implementation and Analysis.

    Science.gov (United States)

    Bhaduri, Aritra; Banerjee, Amitava; Roy, Subhrajit; Kar, Sougata; Basu, Arindam

    2018-03-01

    We present a neuromorphic current mode implementation of a spiking neural classifier with lumped square law dendritic nonlinearity. It has been shown previously in software simulations that such a system with binary synapses can be trained with structural plasticity algorithms to achieve comparable classification accuracy with fewer synaptic resources than conventional algorithms. We show that even in real analog systems with manufacturing imperfections (CV of 23.5% and 14.4% for dendritic branch gains and leaks respectively), this network is able to produce comparable results with fewer synaptic resources. The chip fabricated in [Formula: see text]m complementary metal oxide semiconductor has eight dendrites per cell and uses two opposing cells per class to cancel common-mode inputs. The chip can operate down to a [Formula: see text] V and dissipates 19 nW of static power per neuronal cell and [Formula: see text] 125 pJ/spike. For two-class classification problems of high-dimensional rate encoded binary patterns, the hardware achieves comparable performance as software implementation of the same with only about a 0.5% reduction in accuracy. On two UCI data sets, the IC integrated circuit has classification accuracy comparable to standard machine learners like support vector machines and extreme learning machines while using two to five times binary synapses. We also show that the system can operate on mean rate encoded spike patterns, as well as short bursts of spikes. To the best of our knowledge, this is the first attempt in hardware to perform classification exploiting dendritic properties and binary synapses.

  12. Proceedings of the U.S. Army Symposium on Gun Dynamics (7th) Held in Newport, Rhode Island on 11-13 May 1993

    Science.gov (United States)

    1993-09-01

    partialily de-spun. This will spoil the Magnus effect and thus eliminate the de-stabilizing Magnus moment. When this is the case, the reliability of the...rotational lumped mass rigid body model with flexibility in two directions is considered. The effects of flexibility and the rotor angular speed on the...Formulations of this type introduce dimensionless "orifice coefficients" which are intended to embody the collective effect of the details of the actual

  13. Lumped Thermal Household Model

    DEFF Research Database (Denmark)

    Biegel, Benjamin; Andersen, Palle; Stoustrup, Jakob

    2013-01-01

    pump portfolio. Following, we illustrate two disadvantages of individual models, namely that it requires much computational effort to optimize over a large portfolio, and second that it is difficult to accurately model the houses in certain time periods due to local disturbances. Finally, we propose...

  14. Slag-based saltstone formulations

    International Nuclear Information System (INIS)

    Langton, C.A.

    1987-01-01

    Approximately 400 x 10 6 liters of low-level alkaline salt solution will be treated at the Savannah River Plant (SRP) Defense Waste Processing Facility (DWPF) prior to disposal in concrete vaults at SRP. Treatment involves removal of CS + and Sr +2 followed by solidification and stabilization of potential contaminants in saltstone, a hydrated ceramic waste form. Chromium, technetium, and nitrate releases from saltstone can be significantly reduced by substituting hydraulic blast furnace slag for portland cement in the formulation designs. Slag-based mixes are also compatible with Class F fly ash used in saltstone as a functional extender to control heat of hydration and reduce permeability. A monolithic waste form is produced by the hydration of the slag and fly ash. Soluble ion release (NO 3 - ) is controlled by the saltstone microstructure. Chromium and technetium are less leachable from slag mixes compared to cement-based waste forms because these species are chemically reduced to a lower valence state by ferrous iron in the slag and precipitated as relatively insoluble phases, such as CR(OH) 3 and TcO 2 . 5 refs., 4 figs., 4 tabs

  15. Slag-based saltstone formulations

    International Nuclear Information System (INIS)

    Langton, C.A.

    1987-08-01

    Approximately 400 x 10 6 L of low-level alkaline salt solution will be treated at the Savannah River Plant (SRP) Defense Waste Processing Facility (DWPF) prior to disposal in concrete vaults at SRP. Treatment involves removal of Cs + and Sr +2 , followed by solidification and stabilization of potential contaminants in saltstone, a hydrated ceramic wasteform. Chromium, technetium, and nitrate releases from saltstone can be significantly reduced by substituting hydraulic blast furnace slag for portland cement in the formulation designs. Slag-based mixes are also compatible with the Class F flyash used in saltstone as a functional extender to control heat of hydration and reduce permeability. (Class F flyash is also locally available at SRP.) A monolithic wasteform is produced by the hydration of the slag and flyash. Soluble ion release (NO 3- ) is controlled by the saltstone microstructure. Chromium and technetium are less leachable from slag mixes because these species are chemically reduced to a lower valence state by ferrous iron in the slag and are precipitated as relatively insoluble phases, such as Cr(OH) 3 and TcO 2 . 3 refs., 3 figs., 2 tabs

  16. Policy formulation of public acceptance

    International Nuclear Information System (INIS)

    Kasai, Akihiro

    1978-01-01

    Since 1970, the new policy formulation for public acceptance of the new consideration on the location of electric power generation has been set and applied. The planning and the enforcement being conducted by local public organizations for the local economic build-up with plant location and also the adjustement of the requirements for fishery are two main specific characters in this new policy. The background of this new public acceptance policy, the history and the actual problems about the compensation for the location of power generation plants are reviewed. One new proposal, being recommended by the Policy and Science Laboratory to MITI in 1977 is explained. This is based on the method of promoting the location of power generation plants by public participation placing the redevelopment of regional societies as its basis. The problems concerning the industrial structures in farm villages, fishing villages and the areas of commerce and industry should be systematized, and explained from the viewpoint of outside impact, the characteristics of local areas and the location problems in this new proposal. Finally, the location process and its effectiveness should be put in order. (Nakai, Y.)

  17. Hamiltonian formulation of reduced magnetohydrodynamics

    International Nuclear Information System (INIS)

    Morrison, P.J.; Hazeltine, R.D.

    1983-07-01

    Reduced magnetohydrodynamics (RMHD) has become a principal tool for understanding nonlinear processes, including disruptions, in tokamak plasmas. Although analytical studies of RMHD turbulence have been useful, the model's impressive ability to simulate tokamak fluid behavior has been revealed primarily by numerical solution. The present work describes a new analytical approach, not restricted to turbulent regimes, based on Hamiltonian field theory. It is shown that the nonlinear (ideal) RMHD system, in both its high-beta and low-beta versions, can be expressed in Hanmiltonian form. Thus a Poisson bracket, [ , ], is constructed such that each RMHD field quantitity, xi/sub i/, evolves according to xi/sub i/ = [xi/sub i/,H], where H is the total field energy. The new formulation makes RMHD accessible to the methodology of Hamiltonian mechanics; it has lead, in particular, to the recognition of new RMHD invariants and even exact, nonlinear RMHD solutions. A canonical version of the Poisson bracket, which requires the introduction of additional fields, leads to a nonlinear variational principle for time-dependent RMHD

  18. Formulation of disperse systems science and technology

    CERN Document Server

    Tadros, Tharwat F

    2014-01-01

    This book presents comprehensively the science and technology behind the formulation of disperse systems like emulsions, suspensions, foams and others. Starting with a general introduction, the book covers a broad range of topics like the role of different classes of surfactants, stability of disperse systems, formulation of different dispersions, evaluation of formulations and many more. Many examples are included, too. Written by the experienced author and editor Tharwart Tadros, this book is indispensable for every scientist working in the field.

  19. Formulated arthropod cadavers for pest suppression

    OpenAIRE

    2001-01-01

    Pesticidal and/or antimicrobial biological agent-infected arthropod cadavers are formulated by applying a coating agent once on the surface of the cadaver which either (a) prevents the cadavers from sticking together and/or rupturing or (b) acts as an adhesive for a powder or granule applied to the cadaver to prevent sticking and rupturing. The formulated cadavers maintain or improve infectivity, reproducibility, and survivability. The formulated cadavers can be partially desiccated to improv...

  20. Multiple excitation of supports - Part 1. Formulation

    International Nuclear Information System (INIS)

    Galeao, A.C.N.R.; Barbosa, H.J.C.

    1980-12-01

    The formulation and the solution of a simple specific problem of support movement are presented. The formulation is extended to the general case of infinitesimal elasticity where the approximated solutions are obtained by the variational formulation with spatial discretization by Finite Element Method. Finally, the present usual numerical techniques for the treatment of the resulting ordinary differential equations system are discused: Direct integration, Modal overlap, Spectral response. (E.G.) [pt

  1. Superspace formulation of new nonlinear sigma models

    International Nuclear Information System (INIS)

    Gates, S.J. Jr.

    1983-07-01

    The superspace formulation of two classes of supersymmetric nonlinear σ-models are presented. Two alternative N=1 superspace formulations are given for the d=2 supersymmetric nonlinear σ-models with Killing vector potentials: (a) formulation uses an active central charge and, (b) formulation uses a spurion superfield without inducing a classical breakdown of supersymmetry. The N=2 vector multiplet is used to construct a new class of d=4 nonlinear σ-models which when reduced to d=2 possess N=4 supersymmetry. Implications of these two classes of nonlinear σ-models for N>=4 superfield supergravity are discussed. (author)

  2. airGR: an R-package suitable for large sample hydrology presenting a suite of lumped hydrological models

    Science.gov (United States)

    Thirel, G.; Delaigue, O.; Coron, L.; Perrin, C.; Andreassian, V.

    2016-12-01

    Lumped hydrological models are useful and convenient tools for research, engineering and educational purposes. They propose catchment-scale representations of the precipitation-discharge relationship. Thanks to their limited data requirements, they can be easily implemented and run. With such models, it is possible to simulate a number of hydrological key processes over the catchment with limited structural and parametric complexity, typically evapotranspiration, runoff, underground losses, etc. The Hydrology Group at Irstea (Antony) has been developing a suite of rainfall-runoff models over the past 30 years with the main objectives of designing models as efficient as possible in terms of streamflow simulation, applicable to a wide range of catchments and having low data requirements. This resulted in a suite of models running at different time steps (from hourly to annual) applicable for various issues including water balance estimation, forecasting, simulation of impacts and scenario testing. Recently, Irstea has developed an easy-to-use R-package (R Core Team, 2015; Coron et al., 2016), called airGR, to make these models widely available. It includes: - the water balance annual GR1A (Mouehli et al., 2006), - the monthly GR2M (Mouehli, 2003) models, - three versions of the daily model, namely GR4J (Perrin et al., 2003), GR5J (Le Moine, 2008) and GR6J (Pushpalatha et al., 2011), - the hourly GR4H model (Mathevet, 2005), - a degree-day snow module CemaNeige (Valéry et al., 2014). The airGR package has been designed to facilitate the use by non-expert users and allow the addition of evaluation criteria, models or calibration algorithm selected by the end-user. Each model core is coded in FORTRAN to ensure low computational time. The other package functions (i.e. mainly the calibration algorithm and the efficiency criteria) are coded in R. The package is already used for educational purposes. It allows for convenient implementation of model inter-comparisons and

  3. Glass Ceramic Formulation Data Package

    International Nuclear Information System (INIS)

    Crum, Jarrod V.; Rodriguez, Carmen P.; McCloy, John S.; Vienna, John D.; Chung, Chul-Woo

    2012-01-01

    A glass ceramic waste form is being developed for treatment of secondary waste streams generated by aqueous reprocessing of commercial used nuclear fuel (Crum et al. 2012b). The waste stream contains a mixture of transition metals, alkali, alkaline earths, and lanthanides, several of which exceed the solubility limits of a single phase borosilicate glass (Crum et al. 2009; Caurant et al. 2007). A multi-phase glass ceramic waste form allows incorporation of insoluble components of the waste by designed crystallization into durable heat tolerant phases. The glass ceramic formulation and processing targets the formation of the following three stable crystalline phases: (1) powellite (XMoO4) where X can be (Ca, Sr, Ba, and/or Ln), (2) oxyapatite Yx,Z(10-x)Si6O26 where Y is alkaline earth, Z is Ln, and (3) lanthanide borosilicate (Ln5BSi2O13). These three phases incorporate the waste components that are above the solubility limit of a single-phase borosilicate glass. The glass ceramic is designed to be a single phase melt, just like a borosilicate glass, and then crystallize upon slow cooling to form the targeted phases. The slow cooling schedule is based on the centerline cooling profile of a 2 foot diameter canister such as the Hanford High-Level Waste canister. Up to this point, crucible testing has been used for glass ceramic development, with cold crucible induction melter (CCIM) targeted as the ultimate processing technology for the waste form. Idaho National Laboratory (INL) will conduct a scaled CCIM test in FY2012 with a glass ceramic to demonstrate the processing behavior. This Data Package documents the laboratory studies of the glass ceramic composition to support the CCIM test. Pacific Northwest National Laboratory (PNNL) measured melt viscosity, electrical conductivity, and crystallization behavior upon cooling to identify a processing window (temperature range) for melter operation and cooling profiles necessary to crystallize the targeted phases in the

  4. New lumps of Veselov-Novikov integrable nonlinear equation and new exact rational potentials of two-dimensional stationary Schroedinger equation via ∂-macron-dressing method

    International Nuclear Information System (INIS)

    Dubrovsky, V.G.; Formusatik, I.B.

    2003-01-01

    The scheme for calculating via Zakharov-Manakov ∂-macron-dressing method of new rational solutions with constant asymptotic values at infinity of the famous two-dimensional Veselov-Novikov (VN) integrable nonlinear evolution equation and new exact rational potentials of two-dimensional stationary Schroedinger (2DSchr) equation with multiple pole wave functions is developed. As examples new lumps of VN nonlinear equation and new exact rational potentials of 2DSchr equation with multiple pole of order two wave functions are calculated. Among the constructed rational solutions are as nonsingular and also singular

  5. Lump Kinetic Analysis of Syngas Composition Effect on Fischer-Tropsch Synthesis over Cobalt and Cobalt-Rhenium Alumina Supported Catalyst

    Directory of Open Access Journals (Sweden)

    Dewi Tristantini

    2016-03-01

    Received: 10th November 2015; Revised: 10th February 2016; Accepted: 16th February 2016 How to Cite: Tristantini, D., Suwignjo, R.K. (2016. Lump Kinetic Analysis of Syngas Composition Effect on Fischer-Tropsch Synthesis over Cobalt and Cobalt-Rhenium Alumina Supported Catalyst. Bulletin of Chemical Reaction Engineering & Catalysis, 11 (1: 84-92. (doi:10.9767/bcrec.11.1.424.84-92 Permalink/DOI: http://dx.doi.org/10.9767/bcrec.11.1.424.84-92

  6. Modelling of FCC (Fluid Catalytic Cracking) risers with six lumps; Modelo de elevadores de Unidades de Craqueamento Catalitico com cinetica de seis classes

    Energy Technology Data Exchange (ETDEWEB)

    Baldessar, Fabio; Negrao, Cezar O. Ribeiro; Palu, Claudia [Centro Federal de Educacao Tecnologica do Parana (CEFET-PR), Curitiba, PR (Brazil)

    2004-07-01

    The current work presents a mathematical model of an ascendant flow vertical reactor (riser) of a Fluid Catalytic Cracking Unit. The two-phase flow (gas-solid) and the cracking reactions are admitted one-dimensional and steady state. Mass, momentum and energy conservation equations are considered for each phase (solid and gas). A six-lump kinetic model is employed to evaluate gasoil, gasoline, GLP, fuel gas, light cycle oil and coke fractions. The model results are compared to experimental values from a pilot plant and to another model found in the literature. The results are in good agreement, showing the model has great potential. (author)

  7. A New Resistance Formulation for Carbon Nanotubes

    Directory of Open Access Journals (Sweden)

    Ji-Huan He

    2008-01-01

    Full Text Available A new resistance formulation for carbon nanotubes is suggested using fractal approach. The new formulation is also valid for other nonmetal conductors including nerve fibers, conductive polymers, and molecular wires. Our theoretical prediction agrees well with experimental observation.

  8. Advanced Query Formulation in Deductive Databases.

    Science.gov (United States)

    Niemi, Timo; Jarvelin, Kalervo

    1992-01-01

    Discusses deductive databases and database management systems (DBMS) and introduces a framework for advanced query formulation for end users. Recursive processing is described, a sample extensional database is presented, query types are explained, and criteria for advanced query formulation from the end user's viewpoint are examined. (31…

  9. Aerosol formulation and clinical efficacy of bronchodilators

    NARCIS (Netherlands)

    Zanen, Pieter

    1998-01-01

    This thesis subject is the improvement of the formulation of inhaled aerosols. It is well known that the formulation of inhaled drugs is not optimal: the major part of the mass delivered does not reach the lower airways. This phenomenon is due to the particle size of the inhaled particles, which

  10. Hamiltonian formulation of anomaly free chiral bosons

    International Nuclear Information System (INIS)

    Abdalla, E.; Abdalla, M.C.B.; Devecchi, F.P.; Zadra, A.

    1988-01-01

    Starting out of an anomaly free Lagrangian formulation for chiral scalars, which a Wess-Zumino Term (to cancel the anomaly), we formulate the corresponding hamiltonian problem. Ther we use the (quantum) Siegel invariance to choose a particular, which turns out coincide with the obtained by Floreanini and Jackiw. (author) [pt

  11. Undefined cellulase formulations hinder scientific reproducibility.

    Science.gov (United States)

    Himmel, Michael E; Abbas, Charles A; Baker, John O; Bayer, Edward A; Bomble, Yannick J; Brunecky, Roman; Chen, Xiaowen; Felby, Claus; Jeoh, Tina; Kumar, Rajeev; McCleary, Barry V; Pletschke, Brett I; Tucker, Melvin P; Wyman, Charles E; Decker, Stephen R

    2017-01-01

    In the shadow of a burgeoning biomass-to-fuels industry, biological conversion of lignocellulose to fermentable sugars in a cost-effective manner is key to the success of second-generation and advanced biofuel production. For the effective comparison of one cellulase preparation to another, cellulase assays are typically carried out with one or more engineered cellulase formulations or natural exoproteomes of known performance serving as positive controls. When these formulations have unknown composition, as is the case with several widely used commercial products, it becomes impossible to compare or reproduce work done today to work done in the future, where, for example, such preparations may not be available. Therefore, being a critical tenet of science publishing, experimental reproducibility is endangered by the continued use of these undisclosed products. We propose the introduction of standard procedures and materials to produce specific and reproducible cellulase formulations. These formulations are to serve as yardsticks to measure improvements and performance of new cellulase formulations.

  12. Impulsive response of an automatic transmission system with multiple clearances: Formulation, simulation and experiment

    Science.gov (United States)

    Crowther, Ashley R.; Singh, Rajendra; Zhang, Nong; Chapman, Chris

    2007-10-01

    Impulsive responses in geared systems with multiple clearances are studied when the mean torque excitation and system load change abruptly, with application to a vehicle driveline with an automatic transmission. First, torsional lumped-mass models of the planetary and differential gear sets are formulated using matrix elements. The model is then reduced to address tractable nonlinear problems while successfully retaining the main modes of interest. Second, numerical simulations for the nonlinear model are performed for transient conditions and a typical driving situation that induces an impulsive behaviour simulated. However, initial conditions and excitation and load profiles have to be carefully defined before the model can be numerically solved. It is shown that the impacts within the planetary or differential gears may occur under combinations of engine, braking and vehicle load transients. Our analysis shows that the shaping of the engine transient by the torque converter before reaching the clearance locations is more critical. Third, a free vibration experiment is developed for an analogous driveline with multiple clearances and three experiments that excite different response regimes have been carried out. Good correlations validate the proposed methodology.

  13. GEYSER/TONUS: a coupled multi-D lumped parameter code for reactor thermal hydraulics analysis in case of severe accidents

    Energy Technology Data Exchange (ETDEWEB)

    Petit, M.; Durin, M.; Gauvain, J.

    1995-12-31

    The safety requirements for future light water reactors include accounting for severe accidents in the design process. The design must now include mitigation features to limit pressure and temperature inside the building. Hydrogen concentration is also a major issue for severe accidents. Modelling the thermal hydraulics inside the containment requires the description of complex phenomena such as condensation, stratification, transport of gases and aerosols, heat transfers. The effect of mitigation systems will increase the heterogeneities in the building, and most of those phenomena can be coupled. The GEYSER/TONUS multi-dimensional computer code is under development at CEA Saclay to model this complex situation. It allow the coupling of parts of the containment described in a lumped parameter manner, together with meshed parts. Emphasis is put on the numerical methods used to solve the transient problem, and physical models of classical lumped parameters codes will be adapted for the spatially described zones. The code is developed in the environment of the CASTEM 2000/TRIO EF system which allows to construct sophisticated applications based upon it. (J.S.). 22 refs., 1 fig.

  14. GEYSER/TONUS: a coupled multi-D lumped parameter code for reactor thermal hydraulics analysis in case of severe accidents

    International Nuclear Information System (INIS)

    Petit, M.; Durin, M.; Gauvain, J.

    1995-01-01

    The safety requirements for future light water reactors include accounting for severe accidents in the design process. The design must now include mitigation features to limit pressure and temperature inside the building. Hydrogen concentration is also a major issue for severe accidents. Modelling the thermal hydraulics inside the containment requires the description of complex phenomena such as condensation, stratification, transport of gases and aerosols, heat transfers. The effect of mitigation systems will increase the heterogeneities in the building, and most of those phenomena can be coupled. The GEYSER/TONUS multi-dimensional computer code is under development at CEA Saclay to model this complex situation. It allow the coupling of parts of the containment described in a lumped parameter manner, together with meshed parts. Emphasis is put on the numerical methods used to solve the transient problem, and physical models of classical lumped parameters codes will be adapted for the spatially described zones. The code is developed in the environment of the CASTEM 2000/TRIO EF system which allows to construct sophisticated applications based upon it. (J.S.). 22 refs., 1 fig

  15. GEYSER/TONUS: A coupled multi-D lumped parameter code for reactor thermal hydraulics analysis in case of severe accidents

    Energy Technology Data Exchange (ETDEWEB)

    Petit, M.; Durin, M.; Gauvain, J. [Commissariat a l`Energie Atomique, Gif sur Yvette (France)

    1995-09-01

    In many countries, the safety requirements for future light water reactors include accounting for severe accidents in the design process. As far as the containment is concerned, the design must now include mitigation features to limit the pressure and temperature inside the building. Hydrogen concentration is also a major issue for severe accidents. In this context, new needs appear for the modeling of the thermal hydraulics inside the containment. It requires the description of complex phenomena such as condensation, stratification, transport of gases and aerosols, heat transfers. Moreover, the effect of mitigation systems will increase the heterogeneities in the building, and most of those phenomena can be coupled, as for example hydrogen stratification and condensation. To model such a complex situation, the use of multi-dimensional computer codes seems to be necessary in case of large volumes. The aim of the GEYSER/TONUS computer code is to fulfill this need. This code is currently under development at CEA in Saclay. It will allow the coupling of parts of the containment described in a lumped parameter manner, together with meshed parts. Emphasis is put on the numerical methods used to solve the transient problem, as the objective is to be able to treat complete scenarios. Physical models of classical lumped parameters codes will adapted for the spatially described zones. The code is developed in the environment of the CASTEM 2000/TRIO EF system which allows, thanks to its modular conception, to construct sophisticated applications based upon it.

  16. Distributed ESO based cooperative tracking control for high-order nonlinear multiagent systems with lumped disturbance and application in multi flight simulators systems.

    Science.gov (United States)

    Cong, Zhang

    2018-03-01

    Based on extended state observer, a novel and practical design method is developed to solve the distributed cooperative tracking problem of higher-order nonlinear multiagent systems with lumped disturbance in a fixed communication topology directed graph. The proposed method is designed to guarantee all the follower nodes ultimately and uniformly converge to the leader node with bounded residual errors. The leader node, modeled as a higher-order non-autonomous nonlinear system, acts as a command generator giving commands only to a small portion of the networked follower nodes. Extended state observer is used to estimate the local states and lumped disturbance of each follower node. Moreover, each distributed controller can work independently only requiring the relative states and/or the estimated relative states information between itself and its neighbors. Finally an engineering application of multi flight simulators systems is demonstrated to test and verify the effectiveness of the proposed algorithm. Copyright © 2018 ISA. Published by Elsevier Ltd. All rights reserved.

  17. Formulation of heat absorbing glasses

    Directory of Open Access Journals (Sweden)

    Álvarez-Casariego, Pedro

    1996-06-01

    Full Text Available In the thermal exchanges between buildings and environment, glazing is an element of major importance, for it largely influences the so-called Solar Heat Gain and Thermal Losses. These parameters can be modified by applying different type of coatings onto glass surface or by adding colorant compounds during glass melting. The latter is a cheaper way to control the Solar Heat Gain. The knowledge of the laws governing the interaction between colorant compounds and solar radiation, allows us to define glass formulations achieving specific aesthetic requirements and solar energy absorption. In this paper two examples of application of the modelling of glass colorants spectral absorptance are presented. First is addressed to obtaining a glass with high luminous transmittance and low solar energy transmittance, and the other one to obtaining a glass with neutral colour appearance and minimized solar energy transmittance. Calculation formulas are defined together with photometric properties so-obtained. These type of glasses are particularly suitable to be used as building and automotive glazing, for they retain the mechanical characteristics and possibilities of transformation of standard glass.

    En los intercambios de energía entre un edificio y el medio exterior, el vidrio es el elemento de mayor importancia, por su influencia en la Ganancia de Calor Solar y en las Pérdidas Térmicas. Estos parámetros pueden ser modificados mediante el depósito de capas sobre el vidrio o mediante la adición de compuestos absorbentes de la radiación solar. Esta última vía es la más económica para controlar la Ganancia de Calor Solar. El conocimiento de las leyes que gobiernan la interacción de los diversos colorantes con la radiación solar, permite definir formulaciones de vidrios con características especificas de tipo estético y de absorción energética. En este trabajo se presentan dos ejemplos de aplicación de esta modelización de las

  18. A three-dimensional multiphase flow model for assesing NAPL contamination in porous and fractured media, 1. Formulation

    Science.gov (United States)

    Huyakorn, P. S.; Panday, S.; Wu, Y. S.

    1994-06-01

    A three-dimensional, three-phase numerical model is presented for stimulating the movement on non-aqueous-phase liquids (NAPL's) through porous and fractured media. The model is designed for practical application to a wide variety of contamination and remediation scenarios involving light or dense NAPL's in heterogeneous subsurface systems. The model formulation is first derived for three-phase flow of water, NAPL and air (or vapor) in porous media. The formulation is then extended to handle fractured systems using the dual-porosity and discrete-fracture modeling approaches The model accommodates a wide variety of boundary conditions, including withdrawal and injection well conditions which are treated rigorously using fully implicit schemes. The three-phase of formulation collapses to its simpler forms when air-phase dynamics are neglected, capillary effects are neglected, or two-phase-air-liquid, liquid-liquid systems with one or two active phases are considered. A Galerkin procedure with upstream weighting of fluid mobilities, storage matrix lumping, and fully implicit treatment of nonlinear coefficients and well conditions is used. A variety of nodal connectivity schemes leading to finite-difference, finite-element and hybrid spatial approximations in three dimensions are incorporated in the formulation. Selection of primary variables and evaluation of the terms of the Jacobian matrix for the Newton-Raphson linearized equations is discussed. The various nodal lattice options, and their significance to the computational time and memory requirements with regards to the block-Orthomin solution scheme are noted. Aggressive time-stepping schemes and under-relaxation formulas implemented in the code further alleviate the computational burden.

  19. Canonical operator formulation of nonequilibrium thermodynamics

    International Nuclear Information System (INIS)

    Mehrafarin, M.

    1992-09-01

    A novel formulation of nonequilibrium thermodynamics is proposed which emphasises the fundamental role played by the Boltzmann constant k in fluctuations. The equivalence of this and the stochastic formulation is demonstrated. The k → 0 limit of this theory yields the classical deterministic description of nonequilibrium thermodynamics. The new formulation possesses unique features which bear two important results namely the thermodynamic uncertainty principle and the quantisation of entropy production rate. Such a theory becomes indispensable whenever fluctuations play a significant role. (author). 7 refs

  20. Application of UV Imaging in Formulation Development

    DEFF Research Database (Denmark)

    Sun, Yu; Østergaard, Jesper

    2017-01-01

    defining formulation behavior after exposure to the aqueous environments and pharmaceutical performance is critical in pharmaceutical development, manufacturing and quality control of drugs. UV imaging has been explored as a tool for qualitative and quantitative characterization of drug dissolution...... related to the structural properties of the drug substance or formulation can be monitored. UV imaging is a non-intrusive and simple-to-operate analytical technique which holds potential for providing a mechanistic foundation for formulation development. This review aims to cover applications of UV...

  1. Formulation of 11-dimensional supergravity in superspace

    International Nuclear Information System (INIS)

    Cremmer, E.; Ferrara, S.

    1980-01-01

    We formulate on-shell 11-dimensional supergravity in superspace and express its equations of motion in terms of purely geometrical quantities. All torsion and curvature components are solved in terms of a single superfield Wsub(rstu), totally antisymmetric in its (flat vector) indices. The dimensional reduction of this formulation is expected to be related to the superspace formulation of N = 8 extended supergravity and might explain the origin of the hidden (local) SU(8) and (global) E 7 symmetries present in this theory. (orig.)

  2. An exact approach for aggregated formulations

    DEFF Research Database (Denmark)

    Gamst, Mette; Spoorendonk, Simon; Røpke, Stefan

    Aggregating formulations is a powerful approach for problems to take on tractable forms. Aggregation may lead to loss of information, i.e. the aggregated formulation may be an approximation of the original problem. In branch-and-bound context, aggregation can also complicate branching, e.g. when...... optimality cannot be guaranteed by branching on aggregated variables. We present a generic exact solution method to remedy the drawbacks of aggregation. It combines the original and aggregated formulations and applies Benders' decomposition. We apply the method to the Split Delivery Vehicle Routing Problem....

  3. Chemical-Based Formulation Design: Virtual Experimentation

    DEFF Research Database (Denmark)

    Conte, Elisa; Gani, Rafiqul

    This paper presents a software, the virtual Product-Process Design laboratory (virtual PPD-lab) and the virtual experimental scenarios for design/verification of consumer oriented liquid formulated products where the software can be used. For example, the software can be employed for the design......, the additives and/or their mixtures (formulations). Therefore, the experimental resources can focus on a few candidate product formulations to find the best product. The virtual PPD-lab allows various options for experimentations related to design and/or verification of the product. For example, the selection...... design, model adaptation). All of the above helps to perform virtual experiments by blending chemicals together and observing their predicted behaviour. The paper will highlight the application of the virtual PPD-lab in the design and/or verification of different consumer products (paint formulation...

  4. Understanding Pesticide Risks: Toxicity and Formulation

    OpenAIRE

    Muntz, Helen; Miller, Rhonda; Alston, Diane

    2016-01-01

    This fact sheet provides information about pesticide risks to human health, primary means of pesticide exposure, standardized measures of pesticide toxicity, pesticide signal words and type of pesticide formulations.

  5. Emulsifying Formulation of Rosuvastatin Calcium for Improved ...

    African Journals Online (AJOL)

    solubility study, liquid formulations were prepared using LAS/Capryol 90: Maisine 35-1 as oil phase and. Tween 20 with ... evaluated for globule size, zeta potential, and emulsion properties. ..... surfactants which decreases the electrostatic.

  6. Drug Nanoparticle Formulation Using Ascorbic Acid Derivatives

    Directory of Open Access Journals (Sweden)

    Kunikazu Moribe

    2011-01-01

    Full Text Available Drug nanoparticle formulation using ascorbic acid derivatives and its therapeutic uses have recently been introduced. Hydrophilic ascorbic acid derivatives such as ascorbyl glycoside have been used not only as antioxidants but also as food and pharmaceutical excipients. In addition to drug solubilization, drug nanoparticle formation was observed using ascorbyl glycoside. Hydrophobic ascorbic acid derivatives such as ascorbyl mono- and di-n-alkyl fatty acid derivatives are used either as drugs or carrier components. Ascorbyl n-alkyl fatty acid derivatives have been formulated as antioxidants or anticancer drugs for nanoparticle formulations such as micelles, microemulsions, and liposomes. ASC-P vesicles called aspasomes are submicron-sized particles that can encapsulate hydrophilic drugs. Several transdermal and injectable formulations of ascorbyl n-alkyl fatty acid derivatives were used, including ascorbyl palmitate.

  7. Dynamic psychiatry and the psychodynamic formulation

    African Journals Online (AJOL)

    processes and psychiatric disorders are biological, the range ... The formulation furthermore helps with the initial orientation towards the patient: it anticipates and predicts how the patient ..... contributed to problems with his sexual identity.

  8. Formulation of Thermosensitive Hydrogel Containing Cyclodextrin ...

    African Journals Online (AJOL)

    Materials. Chitosan (deacetylation degree, DDA = 80 %) was obtained from HiMedia Laboratories Pvt. ... Sterile formulations were ... Chilled β-GP aqueous solution (sterilized through ..... generally decreasing away from the center of the tumor.

  9. Current advances on polynomial resultant formulations

    Science.gov (United States)

    Sulaiman, Surajo; Aris, Nor'aini; Ahmad, Shamsatun Nahar

    2017-08-01

    Availability of computer algebra systems (CAS) lead to the resurrection of the resultant method for eliminating one or more variables from the polynomials system. The resultant matrix method has advantages over the Groebner basis and Ritt-Wu method due to their high complexity and storage requirement. This paper focuses on the current resultant matrix formulations and investigates their ability or otherwise towards producing optimal resultant matrices. A determinantal formula that gives exact resultant or a formulation that can minimize the presence of extraneous factors in the resultant formulation is often sought for when certain conditions that it exists can be determined. We present some applications of elimination theory via resultant formulations and examples are given to explain each of the presented settings.

  10. Formulation and Characterization of Biodegradable Medicated ...

    African Journals Online (AJOL)

    PEG)-600, tributyl citrate, PEG-200, PEG-300, PEG-400, PEG-4000, triethyl citrate and castor oil. The gum formulations were characterized for the following parameters: texture profile analysis (TPA), biodegradation, in vitro drug release using a ...

  11. A simplectic formulation of relativistic particle dynamics

    International Nuclear Information System (INIS)

    Tulczyjew, W.M.

    1976-12-01

    Particle mechanics is formulated in terms of symplectic relations and infinitesimal symplectic relations. Generating functions of symplectic relations are shown to be classical counterparts of Green's functions of wave mechanics. (orig.) [de

  12. A sympletic formulation of relativistic particle dynamics

    International Nuclear Information System (INIS)

    Tulczyjew, W.M.

    1977-01-01

    Particle mechanics is formulated in terms of sympletic relations and infinitesimal symplectic relations. Generating functions of symplectic relations are shown to be classical counterparts of Green's functions of wave mechanics. (author)

  13. Paclitaxel Albumin-stabilized Nanoparticle Formulation

    Science.gov (United States)

    This page contains brief information about paclitaxel albumin-stabilized nanoparticle formulation and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials.

  14. The Boltzmann equation in the difference formulation

    Energy Technology Data Exchange (ETDEWEB)

    Szoke, Abraham [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Brooks III, Eugene D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-05-06

    First we recall the assumptions that are needed for the validity of the Boltzmann equation and for the validity of the compressible Euler equations. We then present the difference formulation of these equations and make a connection with the time-honored Chapman - Enskog expansion. We discuss the hydrodynamic limit and calculate the thermal conductivity of a monatomic gas, using a simplified approximation for the collision term. Our formulation is more consistent and simpler than the traditional derivation.

  15. Limitations of high dose carrier based formulations.

    Science.gov (United States)

    Yeung, Stewart; Traini, Daniela; Tweedie, Alan; Lewis, David; Church, Tanya; Young, Paul M

    2018-06-10

    This study was performed to investigate how increasing the active pharmaceutical ingredient (API) content within a formulation affects the dispersion of particles and the aerosol performance efficiency of a carrier based dry powder inhalable (DPI) formulation, using a custom dry powder inhaler (DPI) development rig. Five formulations with varying concentrations of API beclomethasone dipropionate (BDP) between 1% and 30% (w/w) were formulated as a multi-component carrier system containing coarse lactose and fine lactose with magnesium stearate. The morphology of the formulation and each component were investigated using scanning electron micrographs while the particle size was measured by laser diffraction. The aerosol performance, in terms of aerodynamic diameter, was assessed using the British pharmacopeia Apparatus E cascade impactor (Next generation impactor). Chemical analysis of the API was observed by high performance liquid chromatography (HPLC). Increasing the concentration of BDP in the blend resulted in increasing numbers and size of individual agglomerates and densely packed BDP multi-layers on the surface of the lactose carrier. BDP present within the multi-layer did not disperse as individual primary particles but as dense agglomerates, which led to a decrease in aerosol performance and increased percentage of BDP deposition within the Apparatus E induction port and pre-separator. As the BDP concentration in the blends increases, aerosol performance of the formulation decreases, in an inversely proportional manner. Concurrently, the percentage of API deposition in the induction port and pre-separator could also be linked to the amount of micronized particles (BDP and Micronized composite carrier) present in the formulation. The effect of such dose increase on the behaviour of aerosol dispersion was investigated to gain greater insight in the development and optimisation of higher dosed carrier-based formulations. Copyright © 2018 Elsevier B.V. All

  16. Chemicals-Based Formulation Design: Virtual Experimentations

    DEFF Research Database (Denmark)

    Conte, Elisa; Gani, Rafiqul

    2011-01-01

    This paper presents a systematic procedure for virtual experimentations related to the design of liquid formulated products. All the experiments that need to be performed when designing a liquid formulated product (lotion), such as ingredients selection and testing, solubility tests, property mea...... on the design of an insect repellent lotion will show that the software is an essential instrument in decision making, and that it reduces time and resources since experimental efforts can be focused on one or few product alternatives....

  17. Comments on alternate formulations for preequilibrium decay

    International Nuclear Information System (INIS)

    Blann, M.

    1978-01-01

    The physical and mathematical differences of several formulations for preequilibrium decay are discussed. Mathematical models and examples are presented or referred to in order to illustrate what the author believes to be errors in the exciton formulation as being due to improper inclusion of spectator effects. An earlier work of Gadioli et al. is reinterpreted, and quotations therein to work of the present author are corrected

  18. The coevent formulation of quantum theory

    International Nuclear Information System (INIS)

    Wallden, Petros

    2013-01-01

    Understanding quantum theory has been a subject of debate from its birth. Many different formulations and interpretations have been proposed. Here we examine a recent novel formulation, namely the coevents formulation. It is a histories formulation and has as starting point the Feynman path integral and the decoherence functional. The new ontology turns out to be that of a coarse-grained history. We start with a quantum measure defined on the space of histories, and the existence of zero covers rules out single-history as potential reality (the Kochen Specker theorem casted in histories form is a special case of a zero cover). We see that allowing coarse-grained histories as potential realities avoids the previous paradoxes, maintains deductive non-contextual logic (alas non-Boolean) and gives rise to a unique classical domain. Moreover, we can recover the probabilistic predictions of quantum theory with the use of the Cournot's principle. This formulation, being both a realist formulation and based on histories, is well suited conceptually for the purposes of quantum gravity and cosmology.

  19. An herbal formulation for hemorrhoids treatment

    Directory of Open Access Journals (Sweden)

    S. Dehdari

    2017-11-01

    Full Text Available Background and objectives: Hemorrhoids is the most painful rectal disease. Straining and pregnancy seem playing chief roles in the development of hemorrhoids. Symptoms of hemorrhoids may include bleeding, inflammation and pain. Despite current medical efforts, many discomforts of hemorrhoids have not been handled. The aim of the present study was to formulate and evaluate Itrifal-e muqil (IM tablet to achieve desired pharmaceutical properties. Method: Quality control tests of Allium ampeloperasum L, Commiphora mukul (Hook. ex Stocks Engl., Phyllanthus emblica L., Terminalia chebula Retz. and Terminalia bellerica Retz. were performed. Afterwards, different formulations were prepared and their physical properties were evaluated. Subsequently, the formulation was coated and its physicochemical characteristics were assessed. Result: All of the herbs demonstrated good results in quality control tests according to United State Pharmacopeia (USP. Formulation-1 that was completely prepared based on explained manufacturing process of IM in traditional medicine manuscripts did not show suitable pharmaceutical properties. Among different formulations, Formulation-3 that consisted of A. ampeloperasum, C. mukul, P. emblica, T. chebula and T. bellerica, displayed best outcomes through different tests. Conclusion: Modern pharmaceutical approaches can excellently be adapted for IM preparations.

  20. Formulation studies for mirtazapine orally disintegrating tablets.

    Science.gov (United States)

    Yıldız, Simay; Aytekin, Eren; Yavuz, Burçin; Bozdağ Pehlivan, Sibel; Ünlü, Nurşen

    2016-01-01

    Orally disintegrating tablets (ODTs) recently have gained much attention to fulfill the needs for pediatric, geriatric, and psychiatric patients with dysphagia. Aim of this study was to develop new ODT formulations containing mirtazapine, an antidepressant drug molecule having bitter taste, by using simple and inexpensive preparation methods such as coacervation, direct compression and to compare their characteristics with those of reference product (Remereon SolTab). Coacervation method was chosen for taste masking of mirtazapine. In vitro characterization studies such as diameter and thickness, weight variation, tablet hardness, tablet friability and disintegration time were performed on tablet formulations. Wetting time and in vitro dissolution tests of developed ODTs also studied using 900 mL 0.1 N HCl medium, 900 mL pH 6.8 phosphate buffer or 900 mL pH 4.5 acetate buffer at 37 ± 0.2 °C as dissolution medium. Ratio of Eudragit® E-100 was chosen as 6% (w/w) since the dissolution profile of A1 (6% Eudragit® E-100) was found closer to the reference product than A2 (4% Eudragit® E-100) and A3 (8% Eudragit® E-100). Group D, E and F formulations were presented better results in terms of disintegration time. Dissolution results indicated that Group E and F formulations showed optimum properties in all three dissolution media. Formulations D1, D4, D5, E3, E4, F1 and F5 found suitable as ODT formulations due to their favorable disintegration times and dissolution profiles. Developed mirtazapine ODTs were found promising in terms of showing the similar characteristics to the original formulation.

  1. TURVA-2012: Formulation of radionuclide release scenarios

    International Nuclear Information System (INIS)

    Marcos, Nuria; Hjerpe, Thomas; Snellman, Margit; Ikonen, Ari; Smith, Paul

    2014-01-01

    TURVA-2012 is Posiva's safety case in support of the Preliminary Safety Analysis Report (PSAR) and application for a construction licence for a repository for disposal of spent nuclear fuel at the Olkiluoto site in south-western Finland. This paper gives a summary of the scenarios and the methodology followed in formulating them as described in TURVA-2012: Formulation of Radionuclide Release Scenarios (Posiva, 2013). The scenarios are further analysed in TURVA-2012: Assessment of Radionuclide Release Scenarios for the Repository System and TURVA-2012: Biosphere Assessment (Posiva, 2012a, 2012b). The formulation of scenarios takes into account the safety functions of the main barriers of the repository system and the uncertainties in the features, events, and processes (FEP) that may affect the entire disposal system (i.e. repository system plus the surface environment) from the emplacement of the first canister until the far future. In the report TURVA-2012: Performance Assessment (2012d), the performance of the engineered and natural barriers has been assessed against the loads expected during the evolution of the repository system and the site. Uncertainties have been identified and these are taken into account in the formulation of radionuclide release scenarios. The uncertainties in the FEP and evolution of the surface environment are taken into account in formulating the surface environment scenarios used ultimately in estimating radiation exposure. Formulating radionuclide release scenarios for the repository system links the reports Performance Assessment and Assessment of Radionuclide Release Scenarios for the Repository System. The formulation of radionuclide release scenarios for the surface environment brings together biosphere description and the surface environment FEP and is the link to the assessment of the surface environment scenarios summarised in TURVA-2012: Biosphere Assessment. (authors)

  2. Lipid Based Formulations of Biopharmaceutics Classification System (BCS Class II Drugs: Strategy, Formulations, Methods and Saturation

    Directory of Open Access Journals (Sweden)

    Šoltýsová I.

    2016-12-01

    Full Text Available Active ingredients in pharmaceuticals differ by their physico-chemical properties and their bioavailability therefore varies. The most frequently used and most convenient way of administration of medicines is oral, however many drugs are little soluble in water. Thus they are not sufficiently effective and suitable for such administration. For this reason a system of lipid based formulations (LBF was developed. Series of formulations were prepared and tested in water and biorelevant media. On the basis of selection criteria, there were selected formulations with the best emulsification potential, good dispersion in the environment and physical stability. Samples of structurally different drugs included in the Class II of the Biopharmaceutics classification system (BCS were obtained, namely Griseofulvin, Glibenclamide, Carbamazepine, Haloperidol, Itraconazol, Triclosan, Praziquantel and Rifaximin, for testing of maximal saturation in formulations prepared from commercially available excipients. Methods were developed for preparation of formulations, observation of emulsification and its description, determination of maximum solubility of drug samples in the respective formulation and subsequent analysis. Saturation of formulations with drugs showed that formulations 80 % XA and 20 % Xh, 35 % XF and 65 % Xh were best able to dissolve the drugs which supports the hypothesis that it is desirable to identify limited series of formulations which could be generally applied for this purpose.

  3. High-Level Waste Glass Formulation Model Sensitivity Study 2009 Glass Formulation Model Versus 1996 Glass Formulation Model

    International Nuclear Information System (INIS)

    Belsher, J.D.; Meinert, F.L.

    2009-01-01

    This document presents the differences between two HLW glass formulation models (GFM): The 1996 GFM and 2009 GFM. A glass formulation model is a collection of glass property correlations and associated limits, as well as model validity and solubility constraints; it uses the pretreated HLW feed composition to predict the amount and composition of glass forming additives necessary to produce acceptable HLW glass. The 2009 GFM presented in this report was constructed as a nonlinear optimization calculation based on updated glass property data and solubility limits described in PNNL-18501 (2009). Key mission drivers such as the total mass of HLW glass and waste oxide loading are compared between the two glass formulation models. In addition, a sensitivity study was performed within the 2009 GFM to determine the effect of relaxing various constraints on the predicted mass of the HLW glass.

  4. Formulation of Sustained-Release Diltiazem Matrix Tablets Using ...

    African Journals Online (AJOL)

    Erah

    surface, their drug release behavior appears simple, but ... matrix material for the formulation of ..... formulation F5 (,) and reference formulations. ( , □). 0. 50. 100. 150. 200. 250. 300. 0. 3. 6 .... Coviello T, Matricardi P, Marianecci C, Alhaique F.

  5. Plant trial of a fast neutron and gamma-ray transmission gauge for the on-belt determination of moisture in lump coke

    International Nuclear Information System (INIS)

    Millen, M.J.; Rafter, P.T.; Sowerby, B.D.; Rainbow, M.T.; Jelenich, L.

    1990-01-01

    A fast neutron and γ-ray transmission (FNGT) gauge has been used to determine the moisture content of lump coke on the conveyor belt supplying the No. 3 blast furnace at the BHP Newcastle Steelworks. The gauge was operated on-line over the period June 1988-March 1989. Gauge moisture was compared with laboratory moisture, based on 30 increment composite samples taken from the belt, and with moisture determined by a second FNGT gauge on one of the hoppers feeding the conveyor belt. The r.m.s. difference between conveyor gauge moisture and laboratory moisture was 0.24 wt% during the calibration period for two hopper flow on the belt, which is normal plant condition. The accuracy of the conveyor belt gauge was maintained to within 0.37 wt% moisture over the full period of the plant trial. (author)

  6. The application of model with lumped parameters for transient condition analyses of NPP; Primena modela sa koncentrisanim parametrima za analize pelaznih stanja nukleane elektrane

    Energy Technology Data Exchange (ETDEWEB)

    Stankovic, B [Institut GOSA, Beograd (Yugoslavia); Stevanovic, V [Masinski fakultet, Beograd (Yugoslavia)

    1985-07-01

    The transient behaviour of NPP Krsko during the accident of pressurizer spray valve stuck open has been simulated y lumped parameters model of the PWR coolant system components, developed at the faculty of Mechanical Engineering, University of Belgrade. The elementary volumes which are characterised by the process and state parameters, and by junctions which are characterised by the geometrical and flow parameters are basic structure of physical model. The process parameters obtained by the model RESI, show qualitative agreement with the measured valves, in a degree in which the actions of reactor safety engineered system and emergency core cooling system are adequately modelled; in spite of the elementary physical model structure and only the modelling of thermal process in reactor core and equilibrium conditions of pressurizer and steam generator. The pressurizer pressure and liquid level predicted by the non-equilibrium pressurizer model SOP show good agreement until the HIPS (high pressure pumps) is activated. (author)

  7. Estimation of time to rupture in a fire using 6FIRE, a lumped parameter UF6 cylinder transient heat transfer/stress analysis model

    International Nuclear Information System (INIS)

    Williams, W.R.; Anderson, J.C.

    1995-01-01

    The transportation of UF 6 is subject to regulations requiring the evaluation of packaging under a sequence of hypothetical accident conditions including exposure to a 30-min 800 degree C (1475 degree F) fire [10 CFR 71.73(c)(3)]. An issue of continuing interest is whether bare cylinders can withstand such a fire without rupturing. To address this issue, a lumped parameter heat transfer/stress analysis model (6FIRE) has been developed to simulate heating to the point of rupture of a cylinder containing UF 6 when it is exposed to a fire. The model is described, then estimates of time to rupture are presented for various cylinder types, fire temperatures, and fill conditions. An assessment of the quantity of UF 6 released from containment after rupture is also presented. Further documentation of the model is referenced

  8. Formulation and Analysis of the Quantum Radar Cross Section

    Science.gov (United States)

    Brandsema, Matthew J.

    In radar, the amount of returns that an object sends back to the receiver after being struck by an electromagnetic wave is characterized by what is known as the radar cross section, denoted by sigma typically. There are many mechanisms that affect how much radiation is reflected back in the receiver direction, such as reflectivity, physical contours and dimensions, attenuation properties of the materials, projected cross sectional area and so on. All of these characteristics are lumped together in a single value of sigma, which has units of m2. Stealth aircrafts for example are designed to minimize its radar cross section and return the smallest amount of radiation possible in the receiver direction. A new concept has been introduced called quantum radar, that uses correlated quantum states of photons as well as the unique properties of quantum mechanics to ascertain information on a target at a distance. At the time of writing this dissertation, quantum radar is very much in its infancy. There still exist fundamental questions about the feasibility of its implementation, especially in the microwave spectrum. However, what has been theoretically determined, is that quantum radar has a fundamental advantage over classical radar in terms of resolution and returns in certain regimes. Analogous to the classical radar cross section (CRCS), the concept of the quantum radar cross section (QRCS) has been introduced. This quantity measures how an object looks to a quantum radar be describing how a single photon, or small cluster of photons scatter off of a macroscopic target. Preliminary simulations of the basic quantum radar cross section equation have yielded promising results showing an advantage in sidelobe response in comparison to the classical RCS. This document expands upon this idea by providing insight as to where this advantage originates, as well as developing more rigorous simulation analysis, and greatly expanding upon the theory. The expanded theory presented

  9. Formulation of lubricating grease using Beeswax thickener

    Science.gov (United States)

    Suhaila, N.; Japar, A.; Aizudin, M.; Aziz, A.; Najib Razali, Mohd

    2018-04-01

    The issues on environmental pollution has brought the industries to seek the alternative green solutions for lubricating grease formulation. The significant challenges in producing modified grease are in which considering the chosen thickener as one of the environmental friendly material. The main purposes of the current research were to formulate lubricant grease using different types of base oils and to study the effect of thickener on the formulated lubricant grease. Used oil and motor oil were used as the base oils for the grease preparation. Beeswax and Damar were used as thickener and additive. The grease is tested based on its consistency, stability and oil bleeding. The prepared greases achieved grease consistency of grade 2 and 3 except for grease with unfiltered used oil. Grease formulated with used oil and synthetic oil tend to harden and loss its lubricating ability under high temperature compared to motor oil’ grease. Grease modification using environmental friendly thickener were successfully formulated but it is considered as a low temperature grease as the beeswax have low melting point of 62°C-65°C.

  10. Bioequivalence assessment of two formulations of ibuprofen

    KAUST Repository

    Al-Talla, Zeyad

    2011-10-19

    Background: This study assessed the relative bioavailability of two formulations of ibuprofen. The first formulation was Doloraz , produced by Al-Razi Pharmaceutical Company, Amman, Jordan. The second forumulation was Brufen , manufactured by Boots Company, Nottingham, UK. Methods and results: A prestudy validation of ibuprofen demonstrated long-term stability, freeze-thaw stability, precision, and accuracy. Twenty-four healthy volunteers were enrolled in this study. After overnight fasting, the two formulations (test and reference) of ibuprofen (100 mg ibuprofen/5 mL suspension) were administered as a single dose on two treatment days separated by a one-week washout period. After dosing, serial blood samples were drawn for a period of 14 hours. Serum harvested from the blood samples was analyzed for the presence of ibuprofen by high-pressure liquid chromatography with ultraviolet detection. Pharmacokinetic parameters were determined from serum concentrations for both formulations. The 90% confidence intervals of the ln-transformed test/reference treatment ratios for peak plasma concentration and area under the concentration-time curve (AUC) parameters were found to be within the predetermined acceptable interval of 80%-125% set by the US Food and Drug Administration. Conclusion: Analysis of variance for peak plasma concentrations and AUC parameters showed no significant difference between the two formulations and, therefore, Doloraz was considered bioequivalent to Brufen. 2011 Al-Talla et al, publisher and licensee Dove Medical Press Ltd.

  11. Comment on “Beyond the SCS-CN method: A theoretical framework for spatially lumped rainfall-runoff response” by M.S. Bartlett, A.J. Parolari, J.J. McDonnell and A. Porporato

    Science.gov (United States)

    Bartlett et al. [2016] performed a re-interpretation and modification of the space-time lumped USDA NRCS (formerly SCS) Curve Number (CN) method to extend its applicability to forested watersheds. We believe that the well documented limitations of the CN method severely constrains the applicability ...

  12. Cyclodextrins as excipients in tablet formulations.

    Science.gov (United States)

    Conceição, Jaime; Adeoye, Oluwatomide; Cabral-Marques, Helena Maria; Lobo, José Manuel Sousa

    2018-04-22

    This paper aims to provide a critical review of cyclodextrins as excipients in tablet formulations, highlighting: (i) the principal pharmaceutical applications of cyclodextrins; (ii) the most relevant technological aspects in pharmaceutical formulation development; and (iii) the actual regulatory status of cyclodextrins. Moreover, several illustrative examples are presented. Cyclodextrins can be used as complexing excipients in tablet formulations for low-dose drugs. By contrast, for medium-dose drugs and/or when the complexation efficiency is low, the methods to enhance the complexation efficiency play a key part in reducing the cyclodextrin quantity. In addition, these compounds are used as fillers, disintegrants, binders and multifunctional direct compression excipients of the tablets. Copyright © 2018 Elsevier Ltd. All rights reserved.

  13. STRATEGY FORMULATION PROCESS AND INNOVATION PERFORMANCE NEXUS

    Directory of Open Access Journals (Sweden)

    Chijioke Nwachukwu

    2018-03-01

    Full Text Available The purpose of this study is to examine the link between strategy formulation process and innovation performance indicators in microfinance banks in Nigeria (MFBs. 100 employees of leading microfinance banks were randomly selected for this study. 80 questionnaires were returned but only 76 were found usable for the analysis. Regression analysis technique was used in examining the nature of the relationships of the variables and for hypotheses testing. The authors used exploratory factor analysis and Cronbach's alpha to test for the validity and reliability of the questionnaires. The results show that strategy formulation process has a positive effect on process innovation performance, product innovation performance and marketing innovation performance. Thus, all the three hypotheses tested were supported. The authors, therefore, concludes that a systematic strategy formulation process is necessary for firms to achieve and sustain process innovation performance, product innovation performance and marketing innovation performance. This study proposed suggestion for further studies.

  14. Formulating viscous hydrodynamics for large velocity gradients

    International Nuclear Information System (INIS)

    Pratt, Scott

    2008-01-01

    Viscous corrections to relativistic hydrodynamics, which are usually formulated for small velocity gradients, have recently been extended from Navier-Stokes formulations to a class of treatments based on Israel-Stewart equations. Israel-Stewart treatments, which treat the spatial components of the stress-energy tensor τ ij as dynamical objects, introduce new parameters, such as the relaxation times describing nonequilibrium behavior of the elements τ ij . By considering linear response theory and entropy constraints, we show how the additional parameters are related to fluctuations of τ ij . Furthermore, the Israel-Stewart parameters are analyzed for their ability to provide stable and physical solutions for sound waves. Finally, it is shown how these parameters, which are naturally described by correlation functions in real time, might be constrained by lattice calculations, which are based on path-integral formulations in imaginary time

  15. RAACFDb: Rheumatoid arthritis ayurvedic classical formulations database.

    Science.gov (United States)

    Mohamed Thoufic Ali, A M; Agrawal, Aakash; Sajitha Lulu, S; Mohana Priya, A; Vino, S

    2017-02-02

    In the past years, the treatment of rheumatoid arthritis (RA) has undergone remarkable changes in all therapeutic modes. The present newfangled care in clinical research is to determine and to pick a new track for better treatment options for RA. Recent ethnopharmacological investigations revealed that traditional herbal remedies are the most preferred modality of complementary and alternative medicine (CAM). However, several ayurvedic modes of treatments and formulations for RA are not much studied and documented from Indian traditional system of medicine. Therefore, this directed us to develop an integrated database, RAACFDb (acronym: Rheumatoid Arthritis Ayurvedic Classical Formulations Database) by consolidating data from the repository of Vedic Samhita - The Ayurveda to retrieve the available formulations information easily. Literature data was gathered using several search engines and from ayurvedic practitioners for loading information in the database. In order to represent the collected information about classical ayurvedic formulations, an integrated database is constructed and implemented on a MySQL and PHP back-end. The database is supported by describing all the ayurvedic classical formulations for the treatment rheumatoid arthritis. It includes composition, usage, plant parts used, active ingredients present in the composition and their structures. The prime objective is to locate ayurvedic formulations proven to be quite successful and highly effective among the patients with reduced side effects. The database (freely available at www.beta.vit.ac.in/raacfdb/index.html) hopefully enables easy access for clinical researchers and students to discover novel leads with reduced side effects. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  16. Formulation and stability testing of photolabile drugs.

    Science.gov (United States)

    Tønnesen, H H

    2001-08-28

    Exposure of a drug to irradiation can influence the stability of the formulation, leading to changes in the physicochemical properties of the product. The influence of excipients of frequently used stabilizers is often difficult to predict and, therefore, stability testing of the final preparation is important. The selection of a protective packaging must be based on knowledge about the wavelength causing the instability. Details on drug photoreactivity will also be helpful in order to minimize side-effects and/or optimize drug targeting by developing photoresponsive drug delivery systems. This review focuses on practical problems related to formulation and stability testing of photolabile drugs.

  17. Controlled-release tablet formulation of isoniazid.

    Science.gov (United States)

    Jain, N K; Kulkarni, K; Talwar, N

    1992-04-01

    Guar (GG) and Karaya gums (KG) alone and in combination with hydroxy-propylmethylcellulose (HPMC) were evaluated as release retarding materials to formulate a controlled-release tablet dosage form of isoniazid (1). In vitro release of 1 from tablets followed non-Fickian release profile with rapid initial release. Urinary excretion studies in normal subjects showed steady-state levels of 1 for 13 h. In vitro and in vivo data correlated (r = 0.9794). The studies suggested the potentiality of GG and KG as release retarding materials in formulating controlled-release tablet dosage forms of 1.

  18. An exact approach for aggregated formulations

    DEFF Research Database (Denmark)

    Gamst, Mette; Spoorendonk, Simon

    Aggregating formulations is a powerful approach for transforming problems into taking more tractable forms. Aggregated formulations can, though, have drawbacks: some information may get lost in the aggregation and { put in a branch-and-bound context { branching may become very di_cult and even....... The paper includes general considerations on types of problems for which the method is of particular interest. Furthermore, we prove the correctness of the procedure and consider how to include extensions such as cutting planes and advanced branching strategies....

  19. Quaternionic formulation of the exact parity model

    Energy Technology Data Exchange (ETDEWEB)

    Brumby, S.P.; Foot, R.; Volkas, R.R.

    1996-02-28

    The exact parity model (EPM) is a simple extension of the standard model which reinstates parity invariance as an unbroken symmetry of nature. The mirror matter sector of the model can interact with ordinary matter through gauge boson mixing, Higgs boson mixing and, if neutrinos are massive, through neutrino mixing. The last effect has experimental support through the observed solar and atmospheric neutrino anomalies. In the paper it is shown that the exact parity model can be formulated in a quaternionic framework. This suggests that the idea of mirror matter and exact parity may have profound implications for the mathematical formulation of quantum theory. 13 refs.

  20. Quaternionic formulation of the exact parity model

    International Nuclear Information System (INIS)

    Brumby, S.P.; Foot, R.; Volkas, R.R.

    1996-01-01

    The exact parity model (EPM) is a simple extension of the standard model which reinstates parity invariance as an unbroken symmetry of nature. The mirror matter sector of the model can interact with ordinary matter through gauge boson mixing, Higgs boson mixing and, if neutrinos are massive, through neutrino mixing. The last effect has experimental support through the observed solar and atmospheric neutrino anomalies. In the paper it is shown that the exact parity model can be formulated in a quaternionic framework. This suggests that the idea of mirror matter and exact parity may have profound implications for the mathematical formulation of quantum theory. 13 refs

  1. Screening of mucoadhesive vaginal gel formulations

    Directory of Open Access Journals (Sweden)

    Ana Ochoa Andrade

    2014-12-01

    Full Text Available Rational design of vaginal drug delivery formulations requires special attention to vehicle properties that optimize vaginal coating and retention. The aim of the present work was to perform a screening of mucoadhesive vaginal gels formulated with carbomer or carrageenan in binary combination with a second polymer (carbomer, guar or xanthan gum. The gels were characterised using in vitroadhesion, spreadability and leakage potential studies, as well as rheological measurements (stress and frequency sweep tests and the effect of dilution with simulated vaginal fluid (SVF on spreadability. Results were analysed using analysis of variance and multiple factor analysis. The combination of polymers enhanced adhesion of both primary gelling agents, carbomer and carrageenan. From the rheological point of view all formulations presented a similar behaviour, prevalently elastic and characterised by loss tangent values well below 1. No correlation between rheological and adhesion behaviour was found. Carbomer and carrageenan gels containing the highest percentage of xanthan gum displayed good in vitro mucoadhesion and spreadability, minimal leakage potential and high resistance to dilution. The positive results obtained with carrageenan-xanthan gum-based gels can encourage the use of natural biocompatible adjuvants in the composition of vaginal products, a formulation field that is currently under the synthetic domain.

  2. Formulation of Sodium Alginate Nanospheres Containing ...

    African Journals Online (AJOL)

    Purpose: The aim of this work was to formulate sodium alginate nanospheres of amphotericin B by controlled gellification method and to evaluate the role of the nanospheres as a “passive carrier” in targeted antifungal therapy. Methods: Sodium alginate nanospheres of amphotericin B were prepared by controlled ...

  3. [Optimization of formulations for dietetic pastry products].

    Science.gov (United States)

    Villarroel, M; Uquiche, E; Brito, G; Cancino, M

    2000-03-01

    Optimized formulations of dietetic pastry products such as cake and sponge cake premixes were formulated using the surface response methodology. % Emulsifier agent and baking time were the selected independent variables for cake, as well as % emulsifier agent % chlorinated flour the variables selected for sponge cake. Three different level of each variable summing up thirteen experimental formulae of each product were assessed to optimize the variables that could have some influence in the sensory characteristics of these dietetic products. The total sensory quality was determined for both dietetic products using the composite scoring test and a panel of 18 trained judges. Looking at the contour graphic and considering economic aspects the best combination of variables for cake formulation was 2% emulsifier agent and 48 minutes for baking time, With respect to sponge cake, the best combination was 6% emulsifier agent and 48% chlorinated flour. Shelf life studies showed that both dietetic formulations remained stable during storage conditions of 75 days at 30 degrees C. During this period, significant differences in sensory characteristics were not found (p pastry products had good acceptability, and open up marketing opportunities for new products with potential health benefits to consumers.

  4. Facile Colorimetric Determination of Duloxetine in Formulations ...

    African Journals Online (AJOL)

    ... the determination of duloxetine hydrochloride (DX). Methods: Ion-pair spectrophotometric method was employed for the determination of duloxetine hydrochloride (DX) in bulk and pharmaceutical formulations using acidic dye methyl orange (MO) as ion-pairing agent at pH 4 (phthalate buffer). The yellow ion-pair complex ...

  5. Engaged Problem Formulation in IS Research

    DEFF Research Database (Denmark)

    Nielsen, Peter Axel; Persson, John Stouby

    2016-01-01

    problems requires a more substantial engagement with the different stakeholders, especially when their problems are ill structured and situated in complex organizational settings. On this basis, we present an engaged approach to formulating IS problems with, not for, IS practitioners. We have come...

  6. Effects of Methionine Containing Paracetamol Formulation on ...

    African Journals Online (AJOL)

    Effects of Methionine Containing Paracetamol Formulation on Serum Vitamins and Trace Elements in Male Rats. AA Iyanda, JI Anetor, DP Oparinde, FAA Adeniyi. Abstract. Methionine is an effective antidote in the treatment of paracetamol-induced toxicity but at large doses it has been reported to induce or aggravate a ...

  7. State-Space Formulation for Circuit Analysis

    Science.gov (United States)

    Martinez-Marin, T.

    2010-01-01

    This paper presents a new state-space approach for temporal analysis of electrical circuits. The method systematically obtains the state-space formulation of nondegenerate linear networks without using concepts of topology. It employs nodal/mesh systematic analysis to reduce the number of undesired variables. This approach helps students to…

  8. Yang-Mills formulation of interacting strings

    International Nuclear Information System (INIS)

    Chan Hongmo; Tsou Sheungtsun

    1988-06-01

    A suggestion that the theory of interacting open bosonic string be reformulated as a generalised Yang-Mills theory is further elucidated. Moreover, a serious reservation regarding the ordering of operators in the earlier 'proof' of equivalence between the new and standard formulations is now removed. (author)

  9. Initial value formulation of higher derivative gravity

    International Nuclear Information System (INIS)

    Noakes, D.R.

    1983-01-01

    The initial value problem is considered for the conformally coupled scalar field and higher derivative gravity, by expressing the equations of each theory in harmonic coordinates. For each theory it is shown that the (vacuum) equations can take the form of a diagonal hyperbolic system with constraints on the initial data. Consequently these theories possess well-posed initial value formulations

  10. Release Properties of Paracetamol Granulationa Formulated with ...

    African Journals Online (AJOL)

    Theobroma cacao gum, TCG was derived as a dry powder from fresh fruits of Theobroma cacao. Various granulations of paracetamol were prepared with TCG at the concentrations of 0.5 – 4% w/w. Similar formulations were prepared using sodium carboxymethyl cellulose, SCMC and acacia gums as standards. In each ...

  11. Probabilites in the general boundary formulation

    Energy Technology Data Exchange (ETDEWEB)

    Oeckl, Robert [Instituto de Matematicas, UNAM, Campus Morelia, C.P. 58190, Morelia, Michoacan (Mexico)

    2007-05-15

    We give an introductory account of the general boundary formulation of quantum theory. We refine its probability interpretation and emphasize a conceptual and historical perspective. We give motivations from quantum gravity and illustrate them with a scenario for describing gravitons in quantum gravity.

  12. On fictitious domain formulations for Maxwell's equations

    DEFF Research Database (Denmark)

    Dahmen, W.; Jensen, Torben Klint; Urban, K.

    2003-01-01

    We consider fictitious domain-Lagrange multiplier formulations for variational problems in the space H(curl: Omega) derived from Maxwell's equations. Boundary conditions and the divergence constraint are imposed weakly by using Lagrange multipliers. Both the time dependent and time harmonic formu...

  13. Necessity of rethinking oral pediatric formulations

    DEFF Research Database (Denmark)

    Bar-Shalom, Daniel

    2014-01-01

    by all patient groups, is needed, and an automated compounding concept is proposed. The finishing of the formulation is done at the dispensing pharmacy using an automated process. The individual components (pudding-like carrier, microencapsulated drug, and the dispensing robot and its software...

  14. Lagrangian formulation of classical BMT-theory

    International Nuclear Information System (INIS)

    Pupasov-Maksimov, Andrey; Deriglazov, Alexei; Guzman, Walberto

    2013-01-01

    Full text: The most popular classical theory of electron has been formulated by Bargmann, Michel and Telegdi (BMT) in 1959. The BMT equations give classical relativistic description of a charged particle with spin and anomalous magnetic momentum moving in homogeneous electro-magnetic field. This allows to study spin dynamics of polarized beams in uniform fields. In particular, first experimental measurements of muon anomalous magnetic momentum were done using changing of helicity predicted by BMT equations. Surprisingly enough, a systematic formulation and the analysis of the BMT theory are absent in literature. In the present work we particularly fill this gap by deducing Lagrangian formulation (variational problem) for BMT equations. Various equivalent forms of Lagrangian will be discussed in details. An advantage of the obtained classical model is that the Lagrangian action describes a relativistic spinning particle without Grassmann variables, for both free and interacting cases. This implies also the possibility of canonical quantization. In the interacting case, an arbitrary electromagnetic background may be considered, which generalizes the BMT theory formulated to the case of homogeneous fields. The classical model has two local symmetries, which gives an interesting example of constrained classical dynamics. It is surprising, that the case of vanishing anomalous part of the magnetic momentum is naturally highlighted in our construction. (author)

  15. A parcel formulation for Hamiltonian layer models

    NARCIS (Netherlands)

    Bokhove, Onno; Oliver, M.

    Starting from the three-dimensional hydrostatic primitive equations, we derive Hamiltonian N-layer models with isentropic tropospheric and isentropic or isothermal stratospheric layers. Our construction employs a new parcel Hamiltonian formulation which describes the fluid as a continuum of

  16. Clinical pharmacology of novel anticancer drug formulations

    NARCIS (Netherlands)

    Stuurman, F.E.

    2013-01-01

    Studies outlined in this thesis describe the impact of drug formulations on pharmacology of anticancer drugs. It consists of four parts and starts with a review describing the mechanisms of low oral bioavailability of anti-cancer drugs and strategies for improvement of the bioavailability. The

  17. Comparative evaluation of organic formulations of Pseudomonas ...

    African Journals Online (AJOL)

    An experiment was conducted in the laboratory and farm of the Department of Biotechnology, Gauhati University, to explore the potentiality of various organic formulations of Pseudomonas fluorescens (Pf) and to manage bacterial wilt disease of brinjal (Solanum melongena L.) under local conditions. Different organic ...

  18. Formulation and evaluation and terbutaline sulphate and ...

    African Journals Online (AJOL)

    We report the use of low rugosity lactose, product of controlled crystallization of this carrier, in the formulation of terbutaline sulphate and beclomethasone dipropionate dry powder inhalers. The deposition patterns obtained with inhalation mixtures consisting of the modified lactose and each of the micronised drugs ...

  19. Development and Evaluation of Topical Gabapentin Formulations

    Directory of Open Access Journals (Sweden)

    Christopher J. Martin

    2017-08-01

    Full Text Available Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hydrogels containing various permeation enhancers, and a range of proprietary bases including a compounded Lipoderm® formulation; furthermore microneedle facilitated delivery was used as a positive control. Critically, permeation of gabapentin across a human epidermal membrane in vitro was assessed using Franz-type diffusion cells. Subsequently this data was contextualised within the wider scope of the literature. Although reports of topical gabapentin delivery have been shown to vary, largely dependent upon the skin model used, this study demonstrated that 6% (w/w gabapentin 0.75% (w/w Carbopol® hydrogels containing 5% (w/w DMSO or 70% (w/w ethanol and a compounded 10% (w/w gabapentin Lipoderm® formulation were able to facilitate permeation of the molecule across human skin. Further pre-clinical and clinical studies are required to investigate the topical delivery performance and pharmacodynamic actions of prospective formulations.

  20. Development and Evaluation of Topical Gabapentin Formulations

    Science.gov (United States)

    Alcock, Natalie; Hiom, Sarah; Birchall, James C.

    2017-01-01

    Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hydrogels containing various permeation enhancers, and a range of proprietary bases including a compounded Lipoderm® formulation; furthermore microneedle facilitated delivery was used as a positive control. Critically, permeation of gabapentin across a human epidermal membrane in vitro was assessed using Franz-type diffusion cells. Subsequently this data was contextualised within the wider scope of the literature. Although reports of topical gabapentin delivery have been shown to vary, largely dependent upon the skin model used, this study demonstrated that 6% (w/w) gabapentin 0.75% (w/w) Carbopol® hydrogels containing 5% (w/w) DMSO or 70% (w/w) ethanol and a compounded 10% (w/w) gabapentin Lipoderm® formulation were able to facilitate permeation of the molecule across human skin. Further pre-clinical and clinical studies are required to investigate the topical delivery performance and pharmacodynamic actions of prospective formulations. PMID:28867811

  1. Engaged Problem Formulation in IS Research

    DEFF Research Database (Denmark)

    Nielsen, Peter Axel; Persson, John Stouby

    2016-01-01

    “Is this the problem?”: the question that haunts many information systems (IS) researchers when they pursue work relevant to both practice and research. Nevertheless, a deliberate answer to this question requires more than simply asking the involved IS practitioners. Deliberately formulating...

  2. Kit systems for granulated decontamination formulations

    Science.gov (United States)

    Tucker, Mark D.

    2010-07-06

    A decontamination formulation and method of making that neutralizes the adverse health effects of both chemical and biological compounds, especially chemical warfare (CW) and biological warfare (BW) agents, and toxic industrial chemicals. The formulation provides solubilizing compounds that serve to effectively render the chemical and biological compounds, particularly CW and BW compounds, susceptible to attack, and at least one reactive compound that serves to attack (and detoxify or kill) the compound. The formulation includes at least one solubilizing agent, a reactive compound, a sorbent additive, and water. A highly adsorbent sorbent additive (e.g., amorphous silica, sorbitol, mannitol, etc.) is used to "dry out" one or more liquid ingredients into a dry, free-flowing powder that has an extended shelf life, and is more convenient to handle and mix in the field. The formulation can be pre-mixed and pre-packaged as a multi-part kit system, where one or more of the parts are packaged in a powdered, granulated form for ease of handling and mixing in the field.

  3. Application of UV Imaging in Formulation Development.

    Science.gov (United States)

    Sun, Yu; Østergaard, Jesper

    2017-05-01

    Efficient drug delivery is dependent on the drug substance dissolving in the body fluids, being released from dosage forms and transported to the site of action. A fundamental understanding of the interplay between the physicochemical properties of the active compound and pharmaceutical excipients defining formulation behavior after exposure to the aqueous environments and pharmaceutical performance is critical in pharmaceutical development, manufacturing and quality control of drugs. UV imaging has been explored as a tool for qualitative and quantitative characterization of drug dissolution and release with the characteristic feature of providing real-time visualization of the solution phase drug transport in the vicinity of the formulation. Events occurring during drug dissolution and release, such as polymer swelling, drug precipitation/recrystallization, or solvent-mediated phase transitions related to the structural properties of the drug substance or formulation can be monitored. UV imaging is a non-intrusive and simple-to-operate analytical technique which holds potential for providing a mechanistic foundation for formulation development. This review aims to cover applications of UV imaging in the early and late phase pharmaceutical development with a special focus on the relation between structural properties and performance. Potential areas of future advancement and application are also discussed.

  4. Bioequivalence assessment of two formulations of ibuprofen

    Directory of Open Access Journals (Sweden)

    Al-Talla ZA

    2011-10-01

    Full Text Available Zeyad A Al-Talla1, Sabah H Akrawi2, Luke T Tolley3, Salim H Sioud1, Mohammed F Zaater4, Abdul-Hamid M Emwas1 1Analytical and NMR Core Laboratories, King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudia Arabia; 2College of Pharmacy, Al-Ain University, Al-Ain, United Arab Emirates; 3Department of Chemistry and Biochemistry, Southern Illinois University Carbondale, Carbondale, IL, USA; 4Department of Chemistry, Jordan University of Science and Technology, Jordan University of Science and Technology, Irbid, Jordan Background: This study assessed the relative bioavailability of two formulations of ibuprofen. The first formulation was Doloraz®, produced by Al-Razi Pharmaceutical Company, Amman, Jordan. The second forumulation was Brufen®, manufactured by Boots Company, Nottingham, UK. Methods and results: A prestudy validation of ibuprofen demonstrated long-term stability, freeze-thaw stability, precision, and accuracy. Twenty-four healthy volunteers were enrolled in this study. After overnight fasting, the two formulations (test and reference of ibuprofen (100 mg ibuprofen/5 mL suspension were administered as a single dose on two treatment days separated by a one-week washout period. After dosing, serial blood samples were drawn for a period of 14 hours. Serum harvested from the blood samples was analyzed for the presence of ibuprofen by high-pressure liquid chromatography with ultraviolet detection. Pharmacokinetic parameters were determined from serum concentrations for both formulations. The 90% confidence intervals of the ln-transformed test/reference treatment ratios for peak plasma concentration and area under the concentration-time curve (AUC parameters were found to be within the predetermined acceptable interval of 80%–125% set by the US Food and Drug Administration. Conclusion: Analysis of variance for peak plasma concentrations and AUC parameters showed no significant difference between the two formulations and

  5. Topical formulations with superoxide dismutase: influence of formulation composition on physical stability and enzymatic activity.

    Science.gov (United States)

    Di Mambro, Valéria M; Borin, Maria F; Fonseca, Maria J V

    2003-04-24

    Three different topical formulations were supplemented with superoxide dismutase (SOD) and evaluated concerning physical and chemical stabilities in order to determine the most stable formulation that would maintain SOD activity. Physical stability was evaluated by storing the formulation at room temperature, and at 37 and 45 degrees C for 28 days. Samples were collected at 7-day intervals for assessment of rheological behavior. Chemical stability was evaluated by the measurement of enzymatic activity in formulations stored at room temperature and at 45 degrees C for 75 days. The formulations showed a pseudoplastic behavior, with a flow index of less than 1. There was no significant difference in the initial values of flow index, hysteresis loop or minimum apparent viscosity. The simple emulsion and the one stabilized with hydroxyethylcellulose showed decreased viscosity by the 21st day and with higher temperature, but no significant changes concerning the presence of SOD. Although there were no significant changes concerning storage time or temperature, the formulation stabilized with hydroxyethylcellulose showed a marked loss of SOD activity. The addition of SOD to the formulations studied did not affect their physical stability. Simple emulsions or emulsions stabilized with carboxypolymethylene seem to be better bases for enzyme addition than emulsion stabilized with hydroxyethylcellulose.

  6. Simulation of hydrogen mitigation in catalytic recombiner. Part-II: Formulation of a CFD model

    International Nuclear Information System (INIS)

    Prabhudharwadkar, Deoras M.; Iyer, Kannan N.

    2011-01-01

    Research highlights: → Hydrogen transport in containment with recombiners is a multi-scale problem. → A novel methodology worked out to lump the recombiner characteristics. → Results obtained using commercial code FLUENT are cast in the form of correlations. → Hence, coarse grids can obtain accurate distribution of H 2 in containment. → Satisfactory working of the methodology is clearly demonstrated. - Abstract: This paper aims at formulation of a model compatible with CFD code to simulate hydrogen distribution and mitigation using a Passive Catalytic Recombiner in the Nuclear power plant containments. The catalytic recombiner is much smaller in size compared to the containment compartments. In order to fully resolve the recombination processes during the containment simulations, it requires the geometric details of the recombiner to be modelled and a very fine mesh size inside the recombiner channels. This component when integrated with containment mixing calculations would result in a large number of mesh elements which may take large computational times to solve the problem. This paper describes a method to resolve this simulation difficulty. In this exercise, the catalytic recombiner alone was first modelled in detail using the best suited option to describe the reaction rate. A detailed parametric study was conducted, from which correlations for the heat of reaction (hence the rate of reaction) and the heat transfer coefficient were obtained. These correlations were then used to model the recombiner channels as single computational cells providing necessary volumetric sources/sinks to the energy and species transport equations. This avoids full resolution of these channels, thereby allowing larger mesh size in the recombiners. The above mentioned method was successfully validated using both steady state and transient test problems and the results indicate very satisfactory modelling of the component.

  7. Multi-Hamiltonian formulations and stability of higher-derivative extensions of 3d Chern-Simons

    Energy Technology Data Exchange (ETDEWEB)

    Abakumova, V.A.; Kaparulin, D.S.; Lyakhovich, S.L. [Tomsk State University, Physics Faculty, Tomsk (Russian Federation)

    2018-02-15

    Most general third-order 3d linear gauge vector field theory is considered. The field equations involve, besides the mass, two dimensionless constant parameters. The theory admits two-parameter series of conserved tensors with the canonical energy-momentum being a particular representative of the series. For a certain range of the model parameters, the series of conserved tensors include bounded quantities. This makes the dynamics classically stable, though the canonical energy is unbounded in all the instances. The free third-order equations are shown to admit constrained multi-Hamiltonian form with the 00-components of conserved tensors playing the roles of corresponding Hamiltonians. The series of Hamiltonians includes the canonical Ostrogradski's one, which is unbounded. The Hamiltonian formulations with different Hamiltonians are not connected by canonical transformations. This means, the theory admits inequivalent quantizations at the free level. Covariant interactions are included with spinor fields such that the higher-derivative dynamics remains stable at interacting level if the bounded conserved quantity exists in the free theory. In the first-order formalism, the interacting theory remains Hamiltonian and therefore it admits quantization, though the vertices are not necessarily Lagrangian in the third-order field equations. (orig.)

  8. Local normal vector field formulation for periodic scattering problems formulated in the spectral domain

    NARCIS (Netherlands)

    van Beurden, M.C.; Setija, Irwan

    2017-01-01

    We present two adapted formulations, one tailored to isotropic media and one for general anisotropic media, of the normal vector field framework previously introduced to improve convergence near arbitrarily shaped material interfaces in spectral simulation methods for periodic scattering geometries.

  9. Formulation of Pine Tar Antidandruff Shampoo Assessment and Comparison With Some Commercial Formulations

    Directory of Open Access Journals (Sweden)

    M. Gharavi

    1990-07-01

    Full Text Available In this study a pine tar shampoo as a new antidandruff formulation is presented. Assessment of antidandruff preparations has been hampered by the lack of standardized schedules, and reliable methods of evaluation.Some antidandruff agents such as : Zinc pyri-thione pine tar, selenium sulphide and (sulfure were used in shampoos. Samples were coded as numbers 1,2 formulated by us and 3,4 formulated commercially. The grading scheme based on 10 point scale, and corneocyte count was carried out on 50 selected volunte¬ers. Corneocyte count and fungal study proved that pine tor shampoo is effective against pityrosporum ovale. Draize lest was used for determination of the irritancy potential of the samples. Results showed that samples numbered 1,2 were relatively innocous in comparison with the others. I urthermore,s kin sensitination test on rabbit also confirmed the results obtained by Draize test. Consumer judgments proved that all formulations were acceptable.

  10. Design and formulation of nano-sized spray dried efavirenz. Part I: Influence of formulation parameters

    CSIR Research Space (South Africa)

    Katata, L

    2012-10-01

    Full Text Available statistical design with an L8 orthogonal array, was implemented to optimise the formulation parameters of PCL-EFV nanoparticles. The types of sugar (lactose or trehalose), surfactant concentration and solvent (dichloromethane and ethyl acetate) were chosen...

  11. Consistency of canonical formulation of Horava gravity

    International Nuclear Information System (INIS)

    Soo, Chopin

    2011-01-01

    Both the non-projectable and projectable version of Horava gravity face serious challenges. In the non-projectable version, the constraint algebra is seemingly inconsistent. The projectable version lacks a local Hamiltonian constraint, thus allowing for an extra graviton mode which can be problematic. A new formulation (based on arXiv:1007.1563) of Horava gravity which is naturally realized as a representation of the master constraint algebra (instead of the Dirac algebra) studied by loop quantum gravity researchers is presented. This formulation yields a consistent canonical theory with first class constraints; and captures the essence of Horava gravity in retaining only spatial diffeomorphisms as the physically relevant non-trivial gauge symmetry. At the same time the local Hamiltonian constraint is equivalently enforced by the master constraint.

  12. Formulation of diclofenac for dermal delivery.

    Science.gov (United States)

    Goh, Choon Fu; Lane, Majella E

    2014-10-01

    Diclofenac (DF) was first synthesized in the 1960's and is currently available as ophthalmic, oral, parenteral, rectal and skin preparations. This review focuses on the administration of DF to the skin. As a member of the non-steroidal anti-inflammatory (NSAID) group of drugs the primary indications of DF are for the management of inflammation and pain but it is also used to treat actinic keratosis. The specific aims of this paper are to: (i) provide an overview of the pharmacokinetics and metabolism of DF following oral and topical administration; (ii) examine critically the various formulation approaches which have been investigated to enhance dermal delivery of DF; and (iii) identify new formulation strategies for enhanced DF skin penetration. Copyright © 2014 Elsevier B.V. All rights reserved.

  13. Consistency of canonical formulation of Horava gravity

    Energy Technology Data Exchange (ETDEWEB)

    Soo, Chopin, E-mail: cpsoo@mail.ncku.edu.tw [Department of Physics, National Cheng Kung University, Tainan, Taiwan (China)

    2011-09-22

    Both the non-projectable and projectable version of Horava gravity face serious challenges. In the non-projectable version, the constraint algebra is seemingly inconsistent. The projectable version lacks a local Hamiltonian constraint, thus allowing for an extra graviton mode which can be problematic. A new formulation (based on arXiv:1007.1563) of Horava gravity which is naturally realized as a representation of the master constraint algebra (instead of the Dirac algebra) studied by loop quantum gravity researchers is presented. This formulation yields a consistent canonical theory with first class constraints; and captures the essence of Horava gravity in retaining only spatial diffeomorphisms as the physically relevant non-trivial gauge symmetry. At the same time the local Hamiltonian constraint is equivalently enforced by the master constraint.

  14. Principles of ration formulation for ruminants

    International Nuclear Information System (INIS)

    Jayasuriya, M.C.N.

    2002-01-01

    Feeding standards as practiced in developed countries could be misleading when non-conventional feed resources are used in formulating rations for ruminant livestock in developing countries. They tend to reject the poor quality feeds that are available in vast quantities. The non-availability of good quality forage throughout the year and the need to optimise the efficiency of utilisation of locally available feed resources have lead to the application of basic nutritional principles when considering ration formulation. The alternative approach to the use of feeding standards would be to ensure that the production system matches the available resources. The development of feed supplementation strategies based on locally available feed resources require the understanding of the relative roles and nutrient needs of the two-compartment system represented by the micro-organisms in the rumen and the host animal. (author)

  15. Spray drying formulation of amorphous solid dispersions.

    Science.gov (United States)

    Singh, Abhishek; Van den Mooter, Guy

    2016-05-01

    Spray drying is a well-established manufacturing technique which can be used to formulate amorphous solid dispersions (ASDs) which is an effective strategy to deliver poorly water soluble drugs (PWSDs). However, the inherently complex nature of the spray drying process coupled with specific characteristics of ASDs makes it an interesting area to explore. Numerous diverse factors interact in an inter-dependent manner to determine the final product properties. This review discusses the basic background of ASDs, various formulation and process variables influencing the critical quality attributes (CQAs) of the ASDs and aspects of downstream processing. Also various aspects of spray drying such as instrumentation, thermodynamics, drying kinetics, particle formation process and scale-up challenges are included. Recent advances in the spray-based drying techniques are mentioned along with some future avenues where major research thrust is needed. Copyright © 2015 Elsevier B.V. All rights reserved.

  16. Canonical formulation of general-relativistic theories

    International Nuclear Information System (INIS)

    Bergmann, P.G.

    1987-01-01

    With the birth of quantum field theory in the late twenties physicists decided that nature could not be half classical and half quantum, and that the gravitational field ought to be quanticized, just as the electromagnetic field had been. One could accept the group of differomorphisms as a fundamental characteristic of general relativity (and indeed of all general-relativistic theories), and proceed to construct a quantum field-theory that was adapted to that group. Quantization would be attempted by way of a Hamiltonian formulation of the (classical) theory, and quantum commutation relations be patterned after the Poisson brackets arising in that formulation. This program is usually called the canonical quantization program, whereas the weak-field approach is known as covariant quantization. The first steps, conceived entirely within the framework of the classical theory, turned out to be beset with technical and conceptual difficulties, which today are essentially resolved. In this paper the author traces out these initial steps

  17. Planar multibody dynamics formulation, programming and applications

    CERN Document Server

    Nikravesh, Parviz E

    2007-01-01

    Introduction Multibody Mechanical Systems Types of Analyses Methods of Formulation Computer Programming Application Examples Unit System Remarks Preliminaries Reference Axes Scalars and Vectors Matrices Vector, Array, and Matrix Differentiation Equations and Expressions Remarks Problems Fundamentals of Kinematics A Particle Kinematics of a Rigid Body Definitions Remarks Problems Fundamentals of Dynamics Newton's Laws of Motion Dynamics of a Body Force Elements Applied Forces Reaction Force Remarks Problems Point-Coordinates: Kinematics Multipoint

  18. Alternative formulations of the electricity tax

    International Nuclear Information System (INIS)

    2003-01-01

    According to EFTA's surveillance authority ESA, the current form of the electricity tax may have a competition distorting effect since only the industry and a few other sectors are exempt from it. This document discusses four alternative formulations of the electricity tax: same tax for all business sectors and households, defining a maximum payment for each firm, introduce a tax on power transmission, or have taxation only on power used for heating.

  19. Formulation and Evaluation of Bioadhesive Cyproheptadine Tablets ...

    African Journals Online (AJOL)

    Results: The shear stress of 3 % solution of HPMC was greater than that of an equivalent concentration of Carbopol 934P. The values of K, n, R2 and detachment force for the optimized formulation (F0) were 0.269, 0.696, 0.964 and 0.066 Newton (N), respectively, and showed good correlation with the predicted values, thus ...

  20. Ising formulations of many NP problems

    OpenAIRE

    Lucas, Andrew

    2013-01-01

    We provide Ising formulations for many NP-complete and NP-hard problems, including all of Karp's 21 NP-complete problems. This collects and extends mappings to the Ising model from partitioning, covering and satisfiability. In each case, the required number of spins is at most cubic in the size of the problem. This work may be useful in designing adiabatic quantum optimization algorithms.

  1. Ising formulations of many NP problems

    Directory of Open Access Journals (Sweden)

    Andrew eLucas

    2014-02-01

    Full Text Available We provide Ising formulations for many NP-complete and NP-hard problems, including all of Karp's 21 NP-complete problems. This collects and extends mappings to the Ising model from partitioning, covering and satisfiability. In each case, the required number of spins is at most cubic in the size of the problem. This work may be useful in designing adiabatic quantum optimization algorithms.

  2. Microcanonical ensemble formulation of lattice gauge theory

    International Nuclear Information System (INIS)

    Callaway, D.J.E.; Rahman, A.

    1982-01-01

    A new formulation of lattice gauge theory without explicit path integrals or sums is obtained by using the microcanonical ensemble of statistical mechanics. Expectation values in the new formalism are calculated by solving a large set of coupled, nonlinear, ordinary differential equations. The average plaquette for compact electrodynamics calculated in this fashion agrees with standard Monte Carlo results. Possible advantages of the microcanonical method in applications to fermionic systems are discussed

  3. Path Integral Formulation of Anomalous Diffusion Processes

    OpenAIRE

    Friedrich, Rudolf; Eule, Stephan

    2011-01-01

    We present the path integral formulation of a broad class of generalized diffusion processes. Employing the path integral we derive exact expressions for the path probability densities and joint probability distributions for the class of processes under consideration. We show that Continuous Time Random Walks (CTRWs) are included in our framework. A closed expression for the path probability distribution of CTRWs is found in terms of their waiting time distribution as the solution of a Dyson ...

  4. FORMULATION AND EVALUATION OF A HERBAL SHAMPOO

    OpenAIRE

    Gouri Kumar Dash* and Noor Husna Nazirah Binti A. Razak

    2017-01-01

    The study was aimed at formulating and evaluating a complete herbal shampoo containing only traditionally used plant materials. The shampoo contained extracts of Hibiscus rosa-sinensis, Azadirachta indica, Trigonella foenumgraecum, Phyllanthus emblica, Sapindus mukorossi, Acacia concinna and fresh juice of Aloe vera. The physicochemical parameters such as colour, clarity, pH, skin irritation, percentage of solid contents, dirt dispersion, foaming ability and foam stability, wetting time and c...

  5. Prednisone raw material characterization and formulation development

    OpenAIRE

    Leonardo Henrique Toehwé; Livia Deris Prado; Helvécio Vinícius Antunes Rocha

    2018-01-01

    ABSTRACT Solid dosage forms for oral use, particularly tablets, are the most highly used dosage forms in therapy because they are easily administered, have high productivity and relatively low cost and provide a more stable drug to form a semi-solid net. Numerous parameters influence the quality of the final dosage form. In this study, the dissolution profile of 20-mg prednisone tablets bioequivalent to the reference product and three test formulations were evaluated using stability testing. ...

  6. Trigger chemistries for better industrial formulations.

    Science.gov (United States)

    Wang, Hsuan-Chin; Zhang, Yanfeng; Possanza, Catherine M; Zimmerman, Steven C; Cheng, Jianjun; Moore, Jeffrey S; Harris, Keith; Katz, Joshua S

    2015-04-01

    In recent years, innovations and consumer demands have led to increasingly complex liquid formulations. These growing complexities have provided industrial players and their customers access to new markets through product differentiation, improved performance, and compatibility/stability with other products. One strategy for enabling more complex formulations is the use of active encapsulation. When encapsulation is employed, strategies are required to effect the release of the active at the desired location and time of action. One particular route that has received significant academic research effort is the employment of triggers to induce active release upon a specific stimulus, though little has translated for industrial use to date. To address emerging industrial formulation needs, in this review, we discuss areas of trigger release chemistries and their applications specifically as relevant to industrial use. We focus the discussion on the use of heat, light, shear, and pH triggers as applied in several model polymeric systems for inducing active release. The goal is that through this review trends will emerge for how technologies can be better developed to maximize their value through industrial adaptation.

  7. What is Quantum Mechanics? A Minimal Formulation

    Science.gov (United States)

    Friedberg, R.; Hohenberg, P. C.

    2018-03-01

    This paper presents a minimal formulation of nonrelativistic quantum mechanics, by which is meant a formulation which describes the theory in a succinct, self-contained, clear, unambiguous and of course correct manner. The bulk of the presentation is the so-called "microscopic theory", applicable to any closed system S of arbitrary size N, using concepts referring to S alone, without resort to external apparatus or external agents. An example of a similar minimal microscopic theory is the standard formulation of classical mechanics, which serves as the template for a minimal quantum theory. The only substantive assumption required is the replacement of the classical Euclidean phase space by Hilbert space in the quantum case, with the attendant all-important phenomenon of quantum incompatibility. Two fundamental theorems of Hilbert space, the Kochen-Specker-Bell theorem and Gleason's theorem, then lead inevitably to the well-known Born probability rule. For both classical and quantum mechanics, questions of physical implementation and experimental verification of the predictions of the theories are the domain of the macroscopic theory, which is argued to be a special case or application of the more general microscopic theory.

  8. Development of formulation device for periodontal disease.

    Science.gov (United States)

    Sato, Yasuhiko; Oba, Takuma; Watanabe, Norio; Danjo, Kazumi

    2012-01-01

    In addition to providing standard surgical treatment that removes the plaque and infected tissues, medications that can regenerate periodontal tissue are also required in the treatment of periodontal disease. As a form of regenerative medication, various growth factors are expected to be used while treating periodontal disease. A protein-like growth factor is often developed as a lyophilized product with dissolution liquid, considering its instability in the solution state. We have clarified that the formulation for periodontal disease needs to be viscous. When the lyophilized product was dissolved using a sticky solution, various problems were encountered, difficulty in dissolving and air bubbles, for example, and some efforts were needed to prepare the formulation. In this research, to identify the problem of preparing a viscous formulation, a lyophilized product (placebo) and sticky liquid were prepared by using vial and ampoule as the conventional containers. Based on these problems, a prototype administration device was developed, and its functionality was confirmed. As a result, it was suggested that the device with a useful mixing system that could shorten the preparation time was developed.

  9. TURTLE with MAD input (Trace Unlimited Rays Through Lumped Elements) -- A computer program for simulating charged particle beam transport systems and DECAY TURTLE including decay calculations

    Energy Technology Data Exchange (ETDEWEB)

    Carey, D.C.

    1999-12-09

    TURTLE is a computer program useful for determining many characteristics of a particle beam once an initial design has been achieved, Charged particle beams are usually designed by adjusting various beam line parameters to obtain desired values of certain elements of a transfer or beam matrix. Such beam line parameters may describe certain magnetic fields and their gradients, lengths and shapes of magnets, spacings between magnetic elements, or the initial beam accepted into the system. For such purposes one typically employs a matrix multiplication and fitting program such as TRANSPORT. TURTLE is designed to be used after TRANSPORT. For convenience of the user, the input formats of the two programs have been made compatible. The use of TURTLE should be restricted to beams with small phase space. The lumped element approximation, described below, precludes the inclusion of the effect of conventional local geometric aberrations (due to large phase space) or fourth and higher order. A reading of the discussion below will indicate clearly the exact uses and limitations of the approach taken in TURTLE.

  10. Prediction of gasoline yield in a fluid catalytic cracking (FCC riser using k-epsilon turbulence and 4-lump kinetic models: A computational fluid dynamics (CFD approach

    Directory of Open Access Journals (Sweden)

    Muhammad Ahsan

    2015-07-01

    Full Text Available Fluid catalytic cracking (FCC is an essential process for the conversion of gas oil to gasoline. This study is an effort to model the phenomenon numerically using commercial computational fluid dynamics (CFD software, heavy density catalyst and 4-lump kinetic model. Geometry, boundary conditions and dimensions of industrial riser for catalytic cracking unit are conferred for 2D simulation using commercial CFD code FLUENT 6.3. Continuity, momentum, energy and species transport equations, applicable to two phase solid and gas flow, are used to simulate the physical phenomenon as efficient as possible. This study implements and predicts the use of the granular Eulerian multiphase model with species transport. Time accurate transient problem is solved with the prediction of mass fraction profiles of gas oil, gasoline, light gas and coke. The output curves demonstrate the breaking of heavy hydrocarbon in the presence of catalyst. An approach proposed in this study shows good agreement with the experimental and numerical data available in the literature.

  11. Real-time simulation of response to load variation for a ship reactor based on point-reactor double regions and lumped parameter model

    Energy Technology Data Exchange (ETDEWEB)

    Wang Qiao; Zhang De [Department of Nuclear Energy Science and Engineering, Naval University of Engineering, Wuhan 430033 (China); Chen Wenzhen, E-mail: Cwz2@21cn.com [Department of Nuclear Energy Science and Engineering, Naval University of Engineering, Wuhan 430033 (China); Chen Zhiyun [Department of Nuclear Energy Science and Engineering, Naval University of Engineering, Wuhan 430033 (China)

    2011-05-15

    Research highlights: > We calculate the variation of main parameters of the reactor core by the Simulink. > The Simulink calculation software (SCS) can deal well with the stiff problem. > The high calculation precision is reached with less time, and the results can be easily displayed. > The quick calculation of ship reactor transient can be achieved by this method. - Abstract: Based on the point-reactor double regions and lumped parameter model, while the nuclear power plant second loop load is increased or decreased quickly, the Simulink calculation software (SCS) is adopted to calculate the variation of main physical and thermal-hydraulic parameters of the reactor core. The calculation results are compared with those of three-dimensional simulation program. It is indicated that the SCS can deal well with the stiff problem of the point-reactor kinetics equations and the coupled problem of neutronics and thermal-hydraulics. The high calculation precision can be reached with less time, and the quick calculation of parameters of response to load disturbance for the ship reactor can be achieved. The clear image of the calculation results can also be displayed quickly by the SCS, which is very significant and important to guarantee the reactor safety operation.

  12. A Hybrid Lumped Parameters/Finite Element/Boundary Element Model to Predict the Vibroacoustic Characteristics of an Axial Piston Pump

    Directory of Open Access Journals (Sweden)

    Shaogan Ye

    2017-01-01

    Full Text Available Low noise axial piston pumps become the rapid increasing demand in modern hydraulic fluid power systems. This paper proposes a systematic approach to simulate the vibroacoustic characteristics of an axial piston pump using a hybrid lumped parameters/finite element/boundary element (LP/FE/BE model, and large amount of experimental work was performed to validate the model. The LP model was developed to calculate the excitation forces and was validated by a comparison of outlet flow ripples. The FE model was developed to calculate the vibration of the pump, in which the modeling of main friction pairs using different spring elements was presented in detail, and the FE model was validated using experimental modal analysis and measured vibrations. The BE model was used to calculate the noise emitted from the pump, and a measurement of sound pressure level at representative field points in a hemianechoic chamber was conducted to validate the BE model. Comparisons between the simulated and measured results show that the developed LP/FE/BE model is effective in capturing the vibroacoustic characteristics of the pump. The presented approach can be extended to other types of fluid power components and contributes to the development of quieter fluid power systems.

  13. Inhalation Exposure to PM-Bound Polycyclic Aromatic Hydrocarbons Released from Barbecue Grills Powered by Gas, Lump Charcoal, and Charcoal Briquettes.

    Science.gov (United States)

    Badyda, Artur J; Widziewicz, Kamila; Rogula-Kozłowska, Wioletta; Majewski, Grzegorz; Jureczko, Izabela

    2018-01-01

    The present study seeks to define the possible cancer risk arising from the inhalation exposure to particle (PM)-bound polycyclic aromatic hydrocarbons (PAHs) present in barbecue emission gases and to compare the risk depending on the type of fuel used for grill powering. Three types of fuel were compared: liquid propane gas, lump charcoal, and charcoal briquettes. PM 2.5 and PM 2.5-100 were collected during grilling. Subsequently, 16 PAHs congeners were extracted from the PM samples and measured quantitatively using gas chromatography. The content of PM-bound PAHs was used to calculate PAHs deposition in the respiratory tract using the multiple path particle dosimetry model. Finally, a probabilistic risk model was developed to assess the incremental lifetime cancer risk (ILCR) faced by people exposed to PAHs. We found a distinctly greater PAHs formation in case of grills powered by charcoal briquettes. The summary concentration of PAHs (Σ16PAH) ranged from inhale barbecue particles for 5 h a day, 40 days a year exceeds the acceptable level set by the U.S. Environmental Protection Agency. We conclude that the type of heat source used for grilling influences the PM-bound PAHs formation. The greatest concentration of PAHs is generated when grilling over charcoal briquettes. Loading grills with food generates conspicuously more PAHs emissions. Traditional grilling poses cancer risk much above the acceptable limit, as opposed to much less risk involving gas powered grills.

  14. TURTLE with MAD input (Trace Unlimited Rays Through Lumped Elements) -- A computer program for simulating charged particle beam transport systems and DECAY TURTLE including decay calculations

    International Nuclear Information System (INIS)

    Carey, D.C.

    1999-01-01

    TURTLE is a computer program useful for determining many characteristics of a particle beam once an initial design has been achieved, Charged particle beams are usually designed by adjusting various beam line parameters to obtain desired values of certain elements of a transfer or beam matrix. Such beam line parameters may describe certain magnetic fields and their gradients, lengths and shapes of magnets, spacings between magnetic elements, or the initial beam accepted into the system. For such purposes one typically employs a matrix multiplication and fitting program such as TRANSPORT. TURTLE is designed to be used after TRANSPORT. For convenience of the user, the input formats of the two programs have been made compatible. The use of TURTLE should be restricted to beams with small phase space. The lumped element approximation, described below, precludes the inclusion of the effect of conventional local geometric aberrations (due to large phase space) or fourth and higher order. A reading of the discussion below will indicate clearly the exact uses and limitations of the approach taken in TURTLE

  15. Extensive preclinical investigation of polymersomal formulation of doxorubicin versus Doxil-mimic formulation.

    Science.gov (United States)

    Alibolandi, Mona; Abnous, Khalil; Mohammadi, Marzieh; Hadizadeh, Farzin; Sadeghi, Fatemeh; Taghavi, Sahar; Jaafari, Mahmoud Reza; Ramezani, Mohammad

    2017-10-28

    Due to the severe cardiotoxicity of doxorubicin, its usage is limited. This shortcoming could be overcome by modifying pharmacokinetics of the drugs via preparation of various nanoplatforms. Doxil, a well-known FDA-approved nanoplatform of doxorubicin as antineoplastic agent, is frequently used in clinics in order to reduce cardiotoxicity of doxorubicin. Since Doxil shows some shortcomings in clinics including hand and food syndrome and very slow release pattern thus, there is a demand for the development and preparation of new doxorubicin nanoformulation with fewer side effects. The new formulation of the doxorubicin, synthesized previously by our group was extensively examined in the current study. This new formulation is doxorubicin encapsulated in PEG-PLGA polymersomes (PolyDOX). The main aim of the study was to compare the distribution and treatment efficacy of a new doxorubicin-polymersomal formulation (PolyDOX) with regular liposomal formulation (Doxil-mimic) in murine colon adenocarcinoma model. Additionally, the pathological, hematological changes, pharmacodynamics, biodistribution, tolerated dose and survival rate in vivo were evaluated and compared. Murine colon cancer model was induced by subcutaneous inoculation of BALB/c mice with C26 cells. Afterwards, either Doxil-mimic or PolyDOX was administered intravenously. The obtained results from biodistribution study showed a remarkable difference in the distribution of drugs in murine organs. In this regard, Doxil-mimic exhibited prolonged (48h) presence within liver tissues while PolyDOX preferentially accumulate in tumor and the presence in liver 48h post-treatment was significantly lower than that of Doxil-mimic. Obtained results demonstrated comparable final length of life for mice receiving either Doxil-mimic or PolyDOX formulations whereas tolerated dose of mice receiving Doxil-mimic was remarkably higher than those receiving PolyDOX. Therapeutic efficacy of formulation in term of tumor growth rate

  16. Towards a methodology to formulate sustainable diets for livestock: accounting for environmental impact in diet formulation.

    Science.gov (United States)

    Mackenzie, S G; Leinonen, I; Ferguson, N; Kyriazakis, I

    2016-05-28

    The objective of this study was to develop a novel methodology that enables pig diets to be formulated explicitly for environmental impact objectives using a Life Cycle Assessment (LCA) approach. To achieve this, the following methodological issues had to be addressed: (1) account for environmental impacts caused by both ingredient choice and nutrient excretion, (2) formulate diets for multiple environmental impact objectives and (3) allow flexibility to identify the optimal nutritional composition for each environmental impact objective. An LCA model based on Canadian pig farms was integrated into a diet formulation tool to compare the use of different ingredients in Eastern and Western Canada. By allowing the feed energy content to vary, it was possible to identify the optimum energy density for different environmental impact objectives, while accounting for the expected effect of energy density on feed intake. A least-cost diet was compared with diets formulated to minimise the following objectives: non-renewable resource use, acidification potential, eutrophication potential, global warming potential and a combined environmental impact score (using these four categories). The resulting environmental impacts were compared using parallel Monte Carlo simulations to account for shared uncertainty. When optimising diets to minimise a single environmental impact category, reductions in the said category were observed in all cases. However, this was at the expense of increasing the impact in other categories and higher dietary costs. The methodology can identify nutritional strategies to minimise environmental impacts, such as increasing the nutritional density of the diets, compared with the least-cost formulation.

  17. Role reductants in dilute chemical decontamination formulations

    Energy Technology Data Exchange (ETDEWEB)

    Ranganathan, S. [Univ. of New Brunswick (Canada). Dept. of Chemical Engineering; Srinivasan, M.P.; Narasimhan, S.V. [Bhabha Atomic Research Centre (BARC), Trombay, Mumbai (India). Water and Steam Chemistry Lab.; Raghavan, P.S. [Madras Christian Coll., Chennai (India); Gopalan, R. [Madras Christian Coll., Chennai (India). Dept. of Chemistry

    2004-10-01

    Iron(III) oxides are the major corrosion products formed in boiling water reactors. The iron(III) oxides are of two types, namely hematite ({alpha}-Fe{sub 2}O{sub 3}) and maghemite ({gamma}-Fe{sub 2}O{sub 3}). The dissolution of these oxides is in no way simple because of the labile nature of the Fe(III)-O bond towards the chelants. The leaching of metal ions is partially controlled by reductive dissolution. In order to understand the role of the reductant, it is essential to study the dissolution behaviour of a system like Fe{sub 2}O{sub 3}, which does not contain any Fe{sup 2+} in the crystal lattice. The present study was carried out with {gamma}-Fe{sub 2}O{sub 3} and dilute chemical decontamination (DCD) formulations containing ascorbic acid and citric acid with the addition of Fe(II)-L as a reductant. The chelants used for the dissolution process were nitrilotriacetic acid, 2,6-pyridinedicorboxylic acid and ethylenediaminetetraacetic acid. The {gamma}-Fe{sub 2}O{sub 3} was chosen since the earlier studies revealed that the dissolution kinetics of {alpha}-Fe{sub 2}O{sub 3} is slow and it is difficult to dissolve even by strong complexing agents, whereas {gamma}-Fe{sub 2}O{sub 3} dissolution is comparatively easier. This is due to the structural difference between these two oxides. The studies also revealed that the dissolution was partly influenced by the nature of the chelating agents but mainly controlled by the power of the reductants used in the formulation. The dissolution behaviour of {gamma}-Fe{sub 2}O{sub 3} under various experimental conditions is discussed and compared with that of magnetite in order to arrive at a suitable mechanism for the dissolution of iron oxides and emphasize the role of reductants in DCD formulations. (orig.)

  18. Random path formulation of nonrelativistic quantum mechanics

    International Nuclear Information System (INIS)

    Roncadelli, M.

    1993-01-01

    Quantum amplitudes satisfy (almost) the same calculus that probabilities obey in the theory of classical stochastic diffusion processes. As a consequence of this structural analogy, a new formulation of (nonrelativistic) quantum mechanics naturally arises as the quantum counterpart of the Langevin description of (classical) stochastic diffusion processes. Quantum fluctuations are simulated here by a Fresnel white noise (FWN), which is a (real) white noise with imaginary diffusion constant, whose functional (pseudo) measure yields the amplitude distribution for its configurations. Central to this approach is the idea that classical dynamical trajectories in configuration space are perturbed by the FWN. Hence, a single (arbitrary) classical dynamical path gets replaced by a family of quantum random paths (QRPs) - one for each FWN sample - all originating from the same space-time point (x', t'). The QRPs are the basic objects of the present formulation and are given by a Langevin equation with the FWN, whose drift is controlled by a (arbitrary) solution to the classical Hamilton-Jacobi equation. So, our approach is manifestly based on classical dynamics. Now, a transition amplitude is associated with each QRP: it gives the amplitude that a particle starting from (x', t') will reach (x'', t'') by travelling just along the considered QRP. The quantum mechanical propagator (x'', t'' modul x', t') then emerges as the FWN average of the transition amplitude along a QRP. Thus, quantum mechanics looks like classical mechanics as perturbed by the FWN. The general structure of this formulation is discussed in detail, along with some practical and conceptual implications. (author). 14 refs

  19. Formulation of optimal international freight transport objective

    Directory of Open Access Journals (Sweden)

    A. Jarašūnienė

    2002-10-01

    Full Text Available To increase the attraction of Lithuania as a transit country striving to promote carriers' border crossing activities and facilitate customs clearance procedures as well as freight delivery to clients it is necessary to identify the main obstacles, to analyse them and to select adequate measures and means for their elimination. Therefore, on the basis of the formulation of transport freight management objective, as well as basing on the assessment of indeterminacy of external impacts, it would be possible to deduce the main causes of idle time of transport means in customs, to estimate the dependence of service time in proportion to transport flow.

  20. Variational formulation of the Gardner's restacking algorithm

    International Nuclear Information System (INIS)

    Dodin, I.Y.; Fisch, N.J.

    2004-01-01

    The incompressibility of the phase flow of Hamiltonian wave-plasma interactions restrains the class of realizable wave-driven transformations of the particle distribution. After the interaction, the distribution remains composed of the original phase-space elements, or local densities, which are only rearranged (''restacked'') by the wave. A variational formalism is developed to study the corresponding limitations on the energy and momentum transfer. A case of particular interest is a toroidal plasma immersed in a dc magnetic field. The restacking algorithm by Gardner [Phys. Fluids 6, 839 (1963)] is formulated precisely. The minimum energy state for a plasma with a given current is determined

  1. Canonical formulation of IIB D-branes

    International Nuclear Information System (INIS)

    Kamimura, K.

    1998-01-01

    We find Wess-Zumino actions for kappa invariant type IIB D-branes in explicit forms. A simple and compact expression is obtained by the use of spinor variables which are defined as power series of differential forms. Using the Wess-Zumino actions we develop the canonical formulation and find the complete set of the constraint equations for generic type IIB Dp-branes. The conserved global supersymmetry charges are determined and the algebra containing the central charges can be obtained explicitly. (orig.)

  2. A geometric formulation of exceptional field theory

    Energy Technology Data Exchange (ETDEWEB)

    Bosque, Pascal du [Arnold Sommerfeld Center for Theoretical Physics,Department für Physik, Ludwig-Maximilians-Universität München,Theresienstraße 37, 80333 München (Germany); Max-Planck-Institut für Physik, Werner-Heisenberg-Institut, Föhringer Ring 6, 80805 München (Germany); Hassler, Falk [Department of Physics and Astronomy, University of North Carolina, Phillips Hall, CB #3255, 120 E. Cameron Ave., Chapel Hill, NC 27599-3255 (United States); City University of New York, The Graduate Center, 365 Fifth Avenue, New York, NY 10016 (United States); Department of Physics, Columbia University, Pupin Hall, 550 West 120th St., New York, NY 10027 (United States); Lüst, Dieter [Arnold Sommerfeld Center for Theoretical Physics,Department für Physik, Ludwig-Maximilians-Universität München,Theresienstraße 37, 80333 München (Germany); Max-Planck-Institut für Physik, Werner-Heisenberg-Institut, Föhringer Ring 6, 80805 München (Germany); Malek, Emanuel [Arnold Sommerfeld Center for Theoretical Physics,Department für Physik, Ludwig-Maximilians-Universität München,Theresienstraße 37, 80333 München (Germany)

    2017-03-01

    We formulate the full bosonic SL(5) exceptional field theory in a coordinate-invariant manner. Thereby we interpret the 10-dimensional extended space as a manifold with SL(5)×ℝ{sup +}-structure. We show that the algebra of generalised diffeomorphisms closes subject to a set of closure constraints which are reminiscent of the quadratic and linear constraints of maximal seven-dimensional gauged supergravities, as well as the section condition. We construct an action for the full bosonic SL(5) exceptional field theory, even when the SL(5)×ℝ{sup +}-structure is not locally flat.

  3. Preparation and characterization of Slow Release Formulations of ...

    African Journals Online (AJOL)

    alginate beads and characterize the resulting slow release formulations (SRFs) using scanning electron microscopy (SEM), and Fourier Transform infrared spectroscopy (FTIR). Two sets of formulations were made by extrusion into 0.25 M calcium ...

  4. Conference report: formulating better medicines for children: 4th European Paediatric Formulation Initiative conference.

    Science.gov (United States)

    Walsh, Jennifer; Mills, Simon

    2013-01-01

    The fourth annual European Paediatric Formulation Initiative (EuPFI) conference on Formulating Better Medicines for Children was held on 19-20 September 2012 at the Institute of Molecular Genetics Congress Centre, Prague, Czech Republic. The 2-day conference concentrated on the latest advances, challenges and opportunities for developing medicinal products and administration devices for pediatric use, both from European and US perspectives. It was aimed specifically at providing exposure to emerging practical applications, and for illustrating remedies utilized by pediatric drug-development teams to overcome hurdles faced in developing medicines for pediatric patients. The conference format included plenary talks, focus sessions on each of the EuPFI work streams (extemporaneous preparations, excipients, pediatric administration devices, taste masking and taste assessment, age-appropriate formulations), case studies, soapbox sessions and a parallel poster display. This conference report summarizes the keynote lectures and also gives a flavor of other presentations and posters from the conference.

  5. Formulation and Pharmacokinetic Evaluation of Controlled-Release ...

    African Journals Online (AJOL)

    A coating layer was then applied with a mixture of HPMC, ethylcellulose, shellac, and HPMC phthalate. The effect of several formulation variables on in vitro drug release was studied; furthermore, the drug release kinetics of the optimized formulation was evaluated. The in vivo pharmacokinetics of the optimized formulation ...

  6. Super-Group Field Cosmology in Batalin-Vilkovisky Formulation

    Science.gov (United States)

    Upadhyay, Sudhaker

    2016-09-01

    In this paper we study the third quantized super-group field cosmology, a model in multiverse scenario, in Batalin-Vilkovisky (BV) formulation. Further, we propose the superfield/super-antifield dependent BRST symmetry transformations. Within this formulation we establish connection between the two different solutions of the quantum master equation within the BV formulation.

  7. Standardization Of A Siddha Formulation Amukkara Curanam By ...

    African Journals Online (AJOL)

    Amukkara curanam, a Siddha formulation, currently used in all types of gastric disorders, rheumatic pain, insomnia and sexual insufficiency, was investigated for the estimation of the marker compounds, withaferine A and piperine contents in a prepared standard formulation and a commercial formulation by using HPTLC ...

  8. Studies on the antimicrobial properties of formulated creams and ...

    African Journals Online (AJOL)

    Their performances were compared with those of standard antiseptic creams and ointments. The results of agar diffusion studies on cream and ointment formulations revealed that the topical bases used to disperse the medicaments could significantly affect the antimicrobial effectiveness of the formulation. Formulations ...

  9. Formulation and method for preparing gels comprising hydrous aluminum oxide

    Science.gov (United States)

    Collins, Jack L.

    2014-06-17

    Formulations useful for preparing hydrous aluminum oxide gels contain a metal salt including aluminum, an organic base, and a complexing agent. Methods for preparing gels containing hydrous aluminum oxide include heating a formulation to a temperature sufficient to induce gel formation, where the formulation contains a metal salt including aluminum, an organic base, and a complexing agent.

  10. Herbal antihyperlipidemic formulation of cocoa tea: Preparation and ...

    African Journals Online (AJOL)

    Purpose: To prepare and characterize a formulation containing an ethanol extract of Camellia ptilophylla leaves (cocoa tea), with a focus on antihyperlipidemic and anti-obesity activities. Methods: An aloe vera–based formulation of an ethanol extract of cocoa tea (C. ptilophylla) was prepared. The formulation was given ...

  11. A displacement based FE formulation for steady state problems

    NARCIS (Netherlands)

    Yu, Y.

    2005-01-01

    In this thesis a new displacement based formulation is developed for elasto-plastic deformations in steady state problems. In this formulation the displacements are the primary variables, which is in contrast to the more common formulations in terms of the velocities as the primary variables. In a

  12. Animal Diet Formulation with Floating Price

    Directory of Open Access Journals (Sweden)

    S.H Nasseri

    2016-12-01

    Full Text Available In the process of milk production, the highest cost relates to animal feed. Based on reports provided by the experts, around seventy percent of dairy livestock costs included feed costs. In order to minimize the total price of livestock feed, according to the limits of feed sources in each region or season, and also the transportation and maintenance costs and ultimately milk price reduction, optimization of the livestock nutrition program is an essential issue. Because of the uncertainty and lack of precision in the optimal food ration done with existing methods based on linear programming, there is a need to use appropriate methods to meet this purpose. Therefore, in this study formulation of completely mixed nutrient diets of dairy cows is done by using a fuzzy linear programming in early lactation. Application of fuzzy optimization method and floating price make it possible to formulate and change the completely mixed diets with adequate safety margins. Therefore, applications of fuzzy methods in feed rations of dairy cattle are recommended to optimize the diets. Obviously, it would be useful to design suitable software, which provides the possibility of using floating prices to set feed rations by the use of fuzzy optimization method.

  13. The covariant formulation of f ( T ) gravity

    International Nuclear Information System (INIS)

    Krššák, Martin; Saridakis, Emmanuel N

    2016-01-01

    We show that the well-known problem of frame dependence and violation of local Lorentz invariance in the usual formulation of f ( T ) gravity is a consequence of neglecting the role of spin connection. We re-formulate f ( T ) gravity starting from, instead of the ‘pure tetrad’ teleparallel gravity, the covariant teleparallel gravity, using both the tetrad and the spin connection as dynamical variables, resulting in a fully covariant, consistent, and frame-independent version of f ( T ) gravity, which does not suffer from the notorious problems of the usual, pure tetrad, f ( T ) theory. We present the method to extract solutions for the most physically important cases, such as the Minkowski, the Friedmann–Robertson–Walker (FRW) and the spherically symmetric ones. We show that in covariant f ( T ) gravity we are allowed to use an arbitrary tetrad in an arbitrary coordinate system along with the corresponding spin connection, resulting always in the same physically relevant field equations. (paper)

  14. Comparison of different formulations of vitamin D

    International Nuclear Information System (INIS)

    Rashid, H.M.F.; Khalil, K.

    2017-01-01

    Vitamin D Deficiency (VDD) is responsible for a wide spectrum of clinical diseases and vitamin D deficiency prevalence is frightening in most parts of the world including Pakistan. Therefore, supplementations of vitamin D are used in the population at high risk for the prevention and the treatment of vitamin D deficiency. Vitamin D supplementation comes in various formulations both oral and intramuscular. Cholecalciferol is the most commonly used preparation which is given through these routes of administration. There is need to study the fact that how much vitamin D levels are raised after administration of these different formulations as this can be a pivotal factor in determining dosage and route of vitamin D3. Methods: This cross-sectional study conducted on 320 cases and compared the efficacy of various Vitamin D3 preparations in raising Vitamin D levels conducted in Department of Endocrinology and Metabolism, Services Hospital, Lahore from February to July, 2016. Blood serum was drawn for vitamin D level in the cases at the time of presentation and after treatment. Results: Three hundred and twenty patients were enrolled in study and divided into four groups (A, B, C, D). There was no significant difference between groups (A, B, C, D) in change in vitamin d levels after 3 months of treatment (p-Value 0.446). Conclusion: Different preparations of vitamin D are equally effective in raising vitamin D levels at 12 weeks. However, there is a need to conduct large scale studies to further validate these results. (author)

  15. Statistical formulation of gravitational radiation reaction

    International Nuclear Information System (INIS)

    Schutz, B.F.

    1980-01-01

    A new formulation of the radiation-reaction problem is proposed, which is simpler than alternatives which have been used before. The new approach is based on the initial-value problem, uses approximations which need be uniformly valid only in compact regions of space-time, and makes no time-asymmetric assumptions (no a priori introduction of retarded potentials or outgoing-wave asymptotic conditions). It defines radiation reaction to be the expected evolution of a source obtained by averaging over a statistical ensemble of initial conditions. The ensemble is chosen to reflect one's complete lack of information (in real systems) about the initial data for the radiation field. The approach is applied to the simple case of a weak-field, slow-motion source in general relativity, where it yields the usual expressions for radiation reaction when the gauge is chosen properly. There is a discussion of gauge freedom, and another of the necessity of taking into account reaction corrections to the particle-conservation equation. The analogy with the second law of thermodynamics is very close, and suggests that the electromagnetic and thermodynamic arrows of time are the same. Because the formulation is based on the usual initial-value problem, it has no spurious ''runaway'' solutions

  16. Terbinafine: novel formulations that potentiate antifungal activities.

    Science.gov (United States)

    Ma, Y; Chen, X; Guan, S

    2015-03-01

    Terbinafine, an orally and topically active antifungal agent, has been available for the treatment of dermatophytic infections and onychomycosis for more than a decade. In addition, oral administration has been shown to be associated with drug-drug interactions, hepatotoxicity, low concentration at the infected sites, gastrointestinal and systemic side effects and other adverse effects. Since topical drug delivery can provide higher patient compliance, allow immediate access to the infected site and reduce unwanted systemic drug exposure, an improved topical drug delivery approach with high permeability, sustained release and prolonged retainment could overcome the limitations and side effects caused by oral administration. Conventional topical formulations cannot keep the drug in the targeted sites for a long duration of time and hence a novel drug delivery that can avoid the side effects while still providing sustained efficacy in treatment should be developed. This brief review of novel formulations based on polymers and nanostructure carriers provides insight into the efficacy and topical delivery of terbinafine. Copyright 2015 Prous Science, S.A.U. or its licensors. All rights reserved.

  17. Stabilisation de la formule des traces tordue

    CERN Document Server

    Moeglin, Colette

    2016-01-01

    Ce travail en deux volumes donne la preuve de la stabilisation de la formule des trace tordue. Stabiliser la formule des traces tordue est la méthode la plus puissante connue actuellement pour comprendre l'action naturelle du groupe des points adéliques d'un groupe réductif, tordue par un automorphisme, sur les formes automorphes de carré intégrable de ce groupe. Cette compréhension se fait en réduisant le problème, suivant les idées de Langlands, à des groupes plus petits munis d'un certain nombre de données auxiliaires; c'est ce que l'on appelle les données endoscopiques. L'analogue non tordu a été résolu par J. Arthur et dans ce livre on suit la stratégie de celui-ci. Publier ce travail sous forme de livre permet de le rendre le plus complet possible. Les auteurs ont repris la théorie de l'endoscopie tordue développée par R. Kottwitz et D. Shelstad et par J.-P. Labesse. Ils donnent tous les arguments des démonstrations même si nombre d'entre eux se trouvent déjà dans les travaux d'Ar...

  18. Cumulative irritation potential of topical retinoid formulations.

    Science.gov (United States)

    Leyden, James J; Grossman, Rachel; Nighland, Marge

    2008-08-01

    Localized irritation can limit treatment success with topical retinoids such as tretinoin and adapalene. The factors that influence irritant reactions have been shown to include individual skin sensitivity, the particular retinoid and concentration used, and the vehicle formulation. To compare the cutaneous tolerability of tretinoin 0.04% microsphere gel (TMG) with that of adapalene 0.3% gel and a standard tretinoin 0.025% cream. The results of 2 randomized, investigator-blinded studies of 2 to 3 weeks' duration, which utilized a split-face method to compare cumulative irritation scores induced by topical retinoids in subjects with healthy skin, were combined. Study 1 compared TMG 0.04% with adapalene 0.3% gel over 2 weeks, while study 2 compared TMG 0.04% with tretinoin 0.025% cream over 3 weeks. In study 1, TMG 0.04% was associated with significantly lower cumulative scores for erythema, dryness, and burning/stinging than adapalene 0.3% gel. However, in study 2, there were no significant differences in cumulative irritation scores between TMG 0.04% and tretinoin 0.025% cream. Measurements of erythema by a chromameter showed no significant differences between the test formulations in either study. Cutaneous tolerance of TMG 0.04% on the face was superior to that of adapalene 0.3% gel and similar to that of a standard tretinoin cream containing a lower concentration of the drug (0.025%).

  19. Projecting India's energy requirements for policy formulation

    International Nuclear Information System (INIS)

    Parikh, Kirit S.; Karandikar, Vivek; Rana, Ashish; Dani, Prasanna

    2009-01-01

    Energy policy has to have a long-term perspective. To formulate it one needs to know the contours of energy requirements and options. Different approaches have been followed in literature, each with their own problems. A top down econometric approach provides little guidance on policies, while a bottom up approval requires too much knowledge and too many assumptions. Using top-down econometric approach for aggregate overall benchmarking and a detailed activity analysis model, Integrated Energy System Model, for a few large sectors, provides a unique combination for easing the difficulties of policy formulation. The model is described in this paper. Eleven alternate scenarios are built, designed to map out extreme points of feasible options. Results show that even after employing all domestic energy resource to their full potential, there will be a continued rise of fossil fuel use, continued importance of coal, and continued rise of import dependence. Energy efficiency emerges as a major option with a potential to reduce energy requirement by as much as 17%. Scenario results point towards pushing for development of alternative sources. (author)

  20. Factors for formulating strategies for environmental restoration

    International Nuclear Information System (INIS)

    1998-07-01

    This publication focusses on factors which are important for formulating a strategy for environmental restoration. In parallel to this effort, the IAEA has conducted activities in related areas which have been reported in companion reports dealing with (1) the characterization of radioactively contaminated sites for remediation purposes and (2) available technology for cleanup and remediation of radioactively contaminated sites. Additionally, follow-up activities will focus on two other areas, viz. planning and management options for cleanup of contaminated groundwater, and post-restoration monitoring of decommissioned sites. In a separate initiative the IAEA has developed preliminary guidance on radiological criteria for determining when cleanup action is needed and for deciding on when areas have been cleaned up to a sufficient extent. It is also concerned with radioactive contamination of soils, groundwaters, structures and biota which may have the potential for harm to people. It is intended that it will serve as an important source of information and data on the key factors to be considered in the formulation of an environmental restoration strategy