Generalized dynamic model and control of ambiguous mono axial vehicle robot

Directory of Open Access Journals (Sweden)

Frantisek Duchon

2016-09-01

Full Text Available This article deals with the novel concept of ambiguous mono axial vehicle robot. Such robot is a combination of Segway and dicycle, which utilizes the advantages of each chassis. The advantage of dicycle is lower energy consumption during the movement and the higher safety of carried payload. The movable platform inside the ambiguous mono axial vehicle allows using the various sensors or devices. This will change the ambiguous mono axial vehicle to the Segway type robot. Both these modes are necessary to control in the stable mode to ensure the safety of the ambiguous mono axial vehicle’s movement. The main contents of the article contain description of generalized dynamic model of ambiguous mono axial vehicle and related control of ambiguous mono axial vehicle. The proposal is unique in that the same controller is used for both modes. Several simulations verify proposed control schemes and identified parameters. Moreover, the dicycle type of platform has never been used in robotics and that is another novelty.

Retrofitting of beaters with mono-drive at a beater-wheel mill; Nachruestung von Vorschlaegern mit Mono-Antrieb an einer Schlagradmuehle

Energy Technology Data Exchange (ETDEWEB)

Krecher, Johannes J.; Hildebrandt, Rainer [Lignite-Mono-Drive Engineering GmbH, Essen (Germany); Geradts, Paul [RWE Power AG, Grevenbroich (Germany)

2008-07-01

Due to a future energy crisis, the use of the domestic brown coal continuously must be strengthened. At the beginning of 2007, the power station Frimmersdorf of RWE Power AG (Essen, Federal Republic of Germany) commissioned Lignite-Mono-Drive Engineering GmbH (Essen, Federal Republic of Germany) with the retrofitting of a N90.60 beater-wheel mill to a mono-drive-system. Thus, the production losses of 20 GWh/a of the 150 MW brown coal block M should be avoided, and the performance of this brown coal block should be increased by nearly 3 MW. Apart from the milling process and drying process, the authors of the contribution under consideration describe the application and operation results of these mono-drive-mills.

Professional Android Programming with Mono for Android and NETC#

CERN Document Server

McClure, Wallace B; Croft, John J; Dick, Jonathan; Hardy, Chris

2012-01-01

A one-of-a-kind book on Android application development with Mono for Android The wait is over! For the millions of .NET/C# developers who have been eagerly awaiting the book that will guide them through the white-hot field of Android application programming, this is the book. As the first guide to focus on Mono for Android, this must-have resource dives into writing applications against Mono with C# and compiling executables that run on the Android family of devices. Putting the proven Wrox Professional format into practice, the authors provide you with the knowledge you need to become a succ

Fatigue Analysis of a Mono-Tower Platform

DEFF Research Database (Denmark)

Kirkegaard, Poul Henning; Sørensen, John Dalsgaard; Brincker, Rune

In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed thro...... of the natural period, damping ratio, current, stress Spectrum and parameters describing the fatigue strength. Further, soil damping is shown to be significant for the Mono-tower.......In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed...... through linear-elastic fracture mechanics (LEFM). In determining the cumulative fatigue damage, Palmgren-Miner's rule is applied. Element reliability as well as systems reliability is estimated using first-order reliability methods (FORM). The sensitivity of the systems reliability to various parameters...

Job Objectives for M60A1A0S Tank Gunnery

Science.gov (United States)

1976-04-01

aeasuring the costs of an existing, perhaps ineffective prograa — hidden costs, such «• equipment deaage attributable to ■lause, personal Injury, or for...but for review and deliberation by policy aakers : Do the proposed standards reflect what i» known by eneay gunnery capabllitlee-’ And what

Festival nimega Mono / Ivar Sakk

Index Scriptorium Estoniae

Sakk, Ivar, 1962-

2015-01-01

Haapsalu graafilise disaini festival Haapsalu Linnagaleriis: sisaldab ülevaate- ja teemanäitust ning väikest sümpoosioni. Temaatilise aastanäituse motiiv on "MONO". Plakateid on ka välismaa tegijatelt. Kuraator Marko Kekishev

Genetic structure and hierarchical population divergence history of Acer mono var. mono in South and Northeast China.

Directory of Open Access Journals (Sweden)

Chunping Liu

Full Text Available Knowledge of the genetic structure and evolutionary history of tree species across their ranges is essential for the development of effective conservation and forest management strategies. Acer mono var. mono, an economically and ecologically important maple species, is extensively distributed in Northeast China (NE, whereas it has a scattered and patchy distribution in South China (SC. In this study, the genetic structure and demographic history of 56 natural populations of A. mono var. mono were evaluated using seven nuclear microsatellite markers. Neighbor-joining tree and STRUCTURE analysis clearly separated populations into NE and SC groups with two admixed-like populations. Allelic richness significantly decreased with increasing latitude within the NE group while both allelic richness and expected heterozygosity showed significant positive correlation with latitude within the SC group. Especially in the NE region, previous studies in Quercus mongolica and Fraxinus mandshurica have also detected reductions in genetic diversity with increases in latitude, suggesting this pattern may be common for tree species in this region, probably due to expansion from single refugium following the last glacial maximum (LGM. Approximate Bayesian Computation-based analysis revealed two major features of hierarchical population divergence in the species' evolutionary history. Recent divergence between the NE group and the admixed-like group corresponded to the LGM period and ancient divergence of SC groups took place during mid-late Pleistocene period. The level of genetic differentiation was moderate (FST  = 0.073; G'ST  = 0.278 among all populations, but significantly higher in the SC group than the NE group, mirroring the species' more scattered distribution in SC. Conservation measures for this species are proposed, taking into account the genetic structure and past demographic history identified in this study.

Genetic Structure and Hierarchical Population Divergence History of Acer mono var. mono in South and Northeast China

Science.gov (United States)

Shen, Hailong; Hu, Lijiang; Saito, Yoko; Ide, Yuji

2014-01-01

Knowledge of the genetic structure and evolutionary history of tree species across their ranges is essential for the development of effective conservation and forest management strategies. Acer mono var. mono, an economically and ecologically important maple species, is extensively distributed in Northeast China (NE), whereas it has a scattered and patchy distribution in South China (SC). In this study, the genetic structure and demographic history of 56 natural populations of A. mono var. mono were evaluated using seven nuclear microsatellite markers. Neighbor-joining tree and STRUCTURE analysis clearly separated populations into NE and SC groups with two admixed-like populations. Allelic richness significantly decreased with increasing latitude within the NE group while both allelic richness and expected heterozygosity showed significant positive correlation with latitude within the SC group. Especially in the NE region, previous studies in Quercus mongolica and Fraxinus mandshurica have also detected reductions in genetic diversity with increases in latitude, suggesting this pattern may be common for tree species in this region, probably due to expansion from single refugium following the last glacial maximum (LGM). Approximate Bayesian Computation-based analysis revealed two major features of hierarchical population divergence in the species’ evolutionary history. Recent divergence between the NE group and the admixed-like group corresponded to the LGM period and ancient divergence of SC groups took place during mid-late Pleistocene period. The level of genetic differentiation was moderate (FST = 0.073; G′ST = 0.278) among all populations, but significantly higher in the SC group than the NE group, mirroring the species’ more scattered distribution in SC. Conservation measures for this species are proposed, taking into account the genetic structure and past demographic history identified in this study. PMID:24498039

Genetic structure and hierarchical population divergence history of Acer mono var. mono in South and Northeast China.

Science.gov (United States)

Liu, Chunping; Tsuda, Yoshiaki; Shen, Hailong; Hu, Lijiang; Saito, Yoko; Ide, Yuji

2014-01-01

Knowledge of the genetic structure and evolutionary history of tree species across their ranges is essential for the development of effective conservation and forest management strategies. Acer mono var. mono, an economically and ecologically important maple species, is extensively distributed in Northeast China (NE), whereas it has a scattered and patchy distribution in South China (SC). In this study, the genetic structure and demographic history of 56 natural populations of A. mono var. mono were evaluated using seven nuclear microsatellite markers. Neighbor-joining tree and STRUCTURE analysis clearly separated populations into NE and SC groups with two admixed-like populations. Allelic richness significantly decreased with increasing latitude within the NE group while both allelic richness and expected heterozygosity showed significant positive correlation with latitude within the SC group. Especially in the NE region, previous studies in Quercus mongolica and Fraxinus mandshurica have also detected reductions in genetic diversity with increases in latitude, suggesting this pattern may be common for tree species in this region, probably due to expansion from single refugium following the last glacial maximum (LGM). Approximate Bayesian Computation-based analysis revealed two major features of hierarchical population divergence in the species' evolutionary history. Recent divergence between the NE group and the admixed-like group corresponded to the LGM period and ancient divergence of SC groups took place during mid-late Pleistocene period. The level of genetic differentiation was moderate (FST  = 0.073; G'ST  = 0.278) among all populations, but significantly higher in the SC group than the NE group, mirroring the species' more scattered distribution in SC. Conservation measures for this species are proposed, taking into account the genetic structure and past demographic history identified in this study.

Professional iPhone Programming with MonoTouch and .NET/C#

CERN Document Server

McClure, Wallace B; Dunn, Craig

2010-01-01

What .NET C# developers need to enter the hot field of iPhone apps. iPhone applications offer a hot opportunity for developers. Until the open source MonoTouch project, this field was limited to those familiar with Apple's programming languages. Now .NET and C# developers can join the party. This Wrox guide is the first book to cover MonoTouch, preparing developers to take advantage of this lucrative opportunity.: MonoTouch opens the field of iPhone app development to .NET and C# developers for the first time; the Wrox reputation among .NET developers assures them that this guide covers everyt

Roles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes

International Nuclear Information System (INIS)

Wang Bei; Suzuki, Hiroyuki; Kato, Mitsuyasu

2008-01-01

TGF-β activates receptor-regulated Smad (R-Smad) through phosphorylation by type I receptors. Activated R-Smad binds to Smad4 and the complex translocates into the nucleus and stimulates the transcription of target genes through association with co-activators including p300. It is not clear, however, how activated Smad complexes are removed from target genes. In this study, we show that TGF-β enhances the mono-ubiquitination of Smad4. Smad4 mono-ubiquitination was promoted by p300 and suppressed by the c-Ski co-repressor. Smad4 mono-ubiquitination disrupted the interaction with Smad2 in the presence of constitutively active TGF-β type I receptor. Furthermore, mono-ubiquitinated Smad4 was not found in DNA-binding Smad complexes. A Smad4-Ubiquitin fusion protein, which mimics mono-ubiquitinated Smad4, enhanced localization to the cytoplasm. These results suggest that mono-ubiquitination of Smad4 occurs in the transcriptional activator complex and facilitates the turnover of Smad complexes at target genes

Fatigue Reliability Analysis of a Mono-Tower Platform

DEFF Research Database (Denmark)

Kirkegaard, Poul Henning; Sørensen, John Dalsgaard; Brincker, Rune

1991-01-01

In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed thro...... of the natural period, damping ratio, current, stress spectrum and parameters describing the fatigue strength. Further, soil damping is shown to be significant for the Mono-tower.......In this paper, a fatigue reliability analysis of a Mono-tower platform is presented. The failure mode, fatigue failure in the butt welds, is investigated with two different models. The one with the fatigue strength expressed through SN relations, the other with the fatigue strength expressed...... through linear-elastic fracture mechanics (LEFM). In determining the cumulative fatigue damage, Palmgren-Miner's rule is applied. Element reliability, as well as systems reliability, is estimated using first-order reliability methods (FORM). The sensitivity of the systems reliability to various parameters...

Developing C# Apps for iPhone and iPad using MonoTouch

CERN Document Server

Costanich, Bryan

2011-01-01

Developing C# Applications for iPhone and iPad using MonoTouch shows you how to use your existing C# skills to write apps for the iPhone and iPad. Fortunately, there's MonoTouch, Novell's .NET library that allows C# developers to write C# code that executes in iOS. Furthermore, MonoTouch allows you to address all the unique functions of the iPhone, iPod Touch, and iPad. And the big plus: You needn't learn any Objective-C to master MonoTouch!. Former Microsoft engineer and published app-store developer Bryan Costanich shows you how to use the tools you already know to create native apps in iOS

Inversor elevador mono - etapa

OpenAIRE

Herber Ramírez, Juan José De Jesús

2006-01-01

En este trabajo de tesis se estudia una topología Mono - Etapa de un Inversor Elevador. Esta estructura está formada por dos convertidores CD - CD Elevadores bidireccionales en corriente, los cuales son controlados por dos señales senoidales, con cierto nivel de CD, desfasadas 180º. Las principales ventajas que esta topología presenta son: 1) Este Inversor genera de manera natural, mediante el control adecuado, un voltaje CA de salida mayor que el voltaje de CD de entrada ...

Finite Element Analysis Of Structural And Magmatic Interactions At Mono Basin (California)

Science.gov (United States)

La Marra, D.; Manconi, A.; Battaglia, M.

2010-12-01

Mono Basin is a northward trending graben situated east of the Sierra Nevada and west of Cowtrack Mountains, extending from the northern edge of Long Valley Caldera towards the Bodie Hills. From a hydrographic perspective, the Mono Basin is defined by all streams that drain into Mono Lake. The Mono-Inyo Craters forms a prominent 25-km-long volcanic complex from the NW corner of Long Valley caldera to the southern edge of Mono Lake. The late Quaternary Hartley Springs fault occurs along the Sierran range front between June Lake and the northern border of Long Valley Caldera. Recently it has been proposed that the manifestation of the volcanic and of the tectonic activity in this area is likely interrelated. According to Bursik et al (2003), stratigraphic data suggest that during the North Mono-Inyo eruption sequence of ~1350 A.D., a series of strong earthquakes occurred across the end of the North Mono explosive phase and the beginning of the Inyo explosive phase. Moreover, geological and geomorphic features of the Hartley Springs fault are consistent with rupture of the fault during the eruption sequence. We use the Finite Element Method (FEM) to simulate a three-dimensional model and investigate the feedback mechanism between dike intrusion and slip along the Hartley Springs fault. We first validate our numerical model against the Okada (1985) analytical solution for a homogeneous and elastic flat half-space. Subsequently, we evaluate the distribution of local stress changes to study the influence of the Inyo Dike intrusion in ~1350 A.D. on Hartley Springs fault, and how the fault slip may encourage the propagation of dikes towards the surface. To this end, we considered the standard Coulomb stress change as failure criterion. Finally, we analyze the effects of the topography and of vertical and lateral heterogeneities of the crust on the distribution of local and regional stress changes. In this presentation, we highlight the preliminary results of our analysis

Substituent effects on mono-substituted and poly-substituted nitriles; Efeitos dos substituintes em nitrilas mono- e polissubstituidas

Energy Technology Data Exchange (ETDEWEB)

Sofia, Raquel C.R.; Carneiro, Paulo I.B.; Rittner, Roberto [Universidade Estadual de Campinas, SP (Brazil). Inst. de Quimica; Fabi, Marino T [Rhodia S.A., Sao Paulo, SP (Brazil)

1992-12-31

This work studies various mono substituted aliphatic nitriles, Y C H{sub 2} (Y=H, F, Cl, Br, I, OMe, S Me, SEt{sub 2}, Me and Ph), and some reference nitriles (Y=Et, n-Pr, n-Bu, n-Am, n-Hex and n-Hept) 12 refs., 3 tabs.

Humanos salvajes y monos altruistas. Reflexiones sobre Darwin

Directory of Open Access Journals (Sweden)

Jorge Martinez Contreras

2009-10-01

Full Text Available RESUMEN   Darwin propuso en 1871 que preferiría descender de un mono que de los “salvajes”. El mono es un babuino hamadryas que, en un relato de Brehm, salva a un infante de una jauría. Los “salvajes” son los fueguinos a los que visitó en los años 1830. ¿Por qué Darwin fue tan buen observador del comportamiento animal y por qué no dudo discernir en qué consistía la sociedad de cazadores-recolectores de los cuatro grupos de Tierra del Fuego?. Esto es lo que tratamos de dilucidar en este trabajo.   Palabras clave: Darwin, fueguinos, hamadryas, altruismo, egoísmo.

PCNA mono-ubiquitination and activation of translesion DNA polymerases by DNA polymerase {alpha}.

Science.gov (United States)

Suzuki, Motoshi; Niimi, Atsuko; Limsirichaikul, Siripan; Tomida, Shuta; Miao Huang, Qin; Izuta, Shunji; Usukura, Jiro; Itoh, Yasutomo; Hishida, Takashi; Akashi, Tomohiro; Nakagawa, Yoshiyuki; Kikuchi, Akihiko; Pavlov, Youri; Murate, Takashi; Takahashi, Takashi

2009-07-01

Translesion DNA synthesis (TLS) involves PCNA mono-ubiquitination and TLS DNA polymerases (pols). Recent evidence has shown that the mono-ubiquitination is induced not only by DNA damage but also by other factors that induce stalling of the DNA replication fork. We studied the effect of spontaneous DNA replication errors on PCNA mono-ubiquitination and TLS induction. In the pol1L868F strain, which expressed an error-prone pol alpha, PCNA was spontaneously mono-ubiquitinated. Pol alpha L868F had a rate-limiting step at the extension from mismatched primer termini. Electron microscopic observation showed the accumulation of a single-stranded region at the DNA replication fork in yeast cells. For pol alpha errors, pol zeta participated in a generation of +1 frameshifts. Furthermore, in the pol1L868F strain, UV-induced mutations were lower than in the wild-type and a pol delta mutant strain (pol3-5DV), and deletion of the RAD30 gene (pol eta) suppressed this defect. These data suggest that nucleotide misincorporation by pol alpha induces exposure of single-stranded DNA, PCNA mono-ubiquitination and activates TLS pols.

EXPANSIÓN Y DIVERGENCIA DEL LOCUS GH ENTRE EL MONO ARAÑA Y EL CHIMPANCÉ

OpenAIRE

DE MENDOZA, AGNÈS; ESQUIVEL, DOLORES; MARTÍNEZ, IRMA; BARRERA, HUGO

2005-01-01

Para precisar la historia muy particular de la hormona del crecimiento (GH) en los primates, se describieron los loci GH del mono araña, un mono del Nuevo Mundo y del chimpancé, una especie cercana al humano. Al menos seis genes integran ambos loci GH: todos del tipo GH en el mono araña, y dos GHs y cuatro lactógenos placentarios (PLs) en el chimpancé. Las regiones intergénicas del locus del chimpancé presentan un tamaño mayor a las del mono araña. Este trabajo conf...

Comparison between mono-bloc and bi-bloc mandibular advancement devices for obstructive sleep apnea.

Science.gov (United States)

Lee, Woo Hyun; Wee, Jee Hye; Lee, Chul Hee; Kim, Min-Su; Rhee, Chae-Seo; Yun, Pil-Young; Yoon, In-Young; Kim, Jeong-Whun

2013-11-01

Although mandibular advancement device (MAD) is widely used, there are a few papers comparing the efficacy and compliance at the same time according to the type of MAD. The aim of this study is to compare the efficacy and compliance between mono-bloc and bi-bloc MAD in the treatment of obstructive sleep apnea (OSA). Ninety-three patients who treated with mono-bloc MAD and 60 patients with bi-bloc MAD from January 2007 through September 2011 were retrospectively enrolled. All the patients underwent full-night polysomnography(PSG) before and 3 months after MAD was applied. The response rate was significantly higher in the patients using mono-bloc than those using bi-bloc MAD (77.4 vs. 58.3 %; P = 0.012). In contrast, the compliance rate of MAD use was significantly higher in the patients using bi-bloc than those using mono-bloc MAD (68.8 vs. 83.3 %; P = 0.044) at 1 year. According to the severity of OSA, the response rate was significantly higher in severe OSA than in mild to moderate OSA (P = 0.033 for mono-bloc MAD and P = 0.048 for bi-bloc MAD). However, there was no difference in the compliance between mild to moderate OSA and severe OSA. Our study showed that mono-bloc MAD was superior to bi-bloc MAD in efficacy while bi-bloc MAD is superior to mono-bloc MAD in compliance. We propose that both the efficacy and compliance should be considered in using MAD for treatment of OSA.

Three-Dimensional Analysis of dike/fault interaction at Mono Basin (California) using the Finite Element Method

Science.gov (United States)

La Marra, D.; Battaglia, M.

2013-12-01

Mono Basin is a north-trending graben that extends from the northern edge of Long Valley caldera towards the Bodie Hills and is bounded by the Cowtrack Mountains on the east and the Sierra Nevada on the west. The Mono-Inyo Craters volcanic chain forms a north-trending zone of volcanic vents extending from the west moat of the Long Valley caldera to Mono Lake. The Hartley Springs fault transects the southern Mono Craters-Inyo Domes area between the western part of the Long Valley caldera and June Lake. Stratigraphic data suggest that a series of strong earthquakes occurred during the North Mono-Inyo eruption sequence of ~1350 A.D. The spatial and temporal proximity between Hartley Springs Fault motion and the North Mono-Inyo eruption sequence suggests a possible relation between seismic events and eruptions. We investigate the interactions between slip along the Hartley Springs fault and dike intrusion beneath the Mono-Inyo craters using a three-dimensional finite element model of the Mono Basin. We employ a realistic representation of the Basin that includes topography, vertical and lateral heterogeneities of the crust, contact relations between fault planes, and a physical model of the pressure required to propagate the dike. We estimate (a) the distribution of Coulomb stress changes to study the influence of dike intrusion on Hartley Springs fault, and (b) the local stress and volumetric dilatation changes to understand how fault slip may influence the propagation of a dike towards the surface.

Mono Lake sediments preserve a record of recent environmental change

Science.gov (United States)

Meixnerova, J.; Betts, M.; Westacott, S.; Ingalls, M.; Miller, L. G.; Sessions, A. L.; Trower, L.; Geobiology Course, A.

2017-12-01

Modern Mono Lake is a geochemically unique closed-basin, hypersaline soda lake. Since 1941, anthropogenic water diversions have decreased the lake's volume and water level, driving changes in water chemistry and ecology. Mono Lake sediments offer an opportunity to investigate the nature and extent of these changes. We analyzed a 70 cm sediment core from the center of Mono Lake recording the past 116 years of deposition. At the time of recovery, the entire core was dark green. 16S rRNA gene analysis indicated a sedimentary bacterial community dominated by Cyanobacteria. SEM imaging revealed abundant, well-preserved diatom frustules below 10 cm core depth, in contrast they are nearly absent above 10 cm depth. Fatty acid (FAME) biomarkers for diatoms and algal sterols were present throughout the core in varying concentrations. Phytol was exceptionally abundant in the core; ratios of phytol/C-18 FAME were commonly >200. The δ13Corg ranged between -17.5 and -20‰ in the lower 52 cm of the core while the upper part shows significant decrease of δ13Corg to -28‰. We interpret the shift in δ13Corg as an ecological transition from mainly diatoms in the lower core towards the green alga Picocystis, which is the main primary producer today and has a δ13Corg value of -32.5‰. The onset of this change dates back 23 years, which roughly coincides with the highest reported salinity, 88 g/L in 1995. We hypothesize that diatoms gradually became marginalized as a result of hypersaline conditions. We also observed a variety of trends that may be characterized as unique fingerprints of Mono Lake. The unusually high abundance of phytol was consistent with the core's pervasive green coloring and could potentially indicate a higher preservation potential of phytol under alkaline conditions. Throughout the core, δ15Norg fluctuated between +10 and +13‰. Such atypical enrichment in δ15Norg could be explained by NH4 dissociation and subsequent NH3 volatilization under high p

2 keV filters of quasi-mono-energetic neutrons

International Nuclear Information System (INIS)

Adib, M.; Habib, N.; El-Mesiry, M.S.; Bashter, I.I.; Saleh, A.; Fathallah, M.

2013-01-01

A simulation study for the production of 2 keV filters of quasi-mono-energetic neutrons based on the deep interference minima in the 45 Sc total cross-section was carried out. A computer code QMENF-II was adapted to calculate the optimum amounts of the 45 Sc as a main filter element and additional component ones to obtain sufficient intensity at high resolution and purity of the filtered quasi-mono-energetic neutrons. The emitted neutron spectrum from nuclear reactor and from the reaction of 2.6 MeV protons on a lithium fluoride target at the accelerator beam port, are used for simulation

Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions

Directory of Open Access Journals (Sweden)

Giovanna Bosica

2016-06-01

Full Text Available Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs.

High-resolution aeromagnetic survey of the Mono Basin-Long Valley Caldera region, California

Science.gov (United States)

Ponce, D. A.; Mangan, M.; McPhee, D.

2013-12-01

A new high-resolution aeromagnetic survey of the Mono Basin-Long Valley Caldera region greatly enhances previous magnetic interpretations that were based on older, low-resolution, and regional aeromagnetic data sets and provides new insights into volcano-tectonic processes. The surveyed area covers a 8,750 km2 NNW-trending swath situated between the Sierra Nevada to the west and the Basin and Range Province to the east. The surveyed area includes the volcanic centers of Mono Lake, Mono-Inyo Craters, Mammoth Mountain, Devils Postpile, and Long Valley Caldera. The NW-trending eastern Sierra frontal fault zone crosses through the study area, including the active Mono Lake, Silver Lake, Hartley Springs, Laurel Creek, and Hilton Creek faults. Over 6,000 line-kilometers of aeromagnetic data were collected at a constant terrain clearance of 150 m, a flight-line spacing of 400 m, and a tie-line spacing of 4 km. Data were collected via helicopter with an attached stinger housing a magnetic sensor using a Scintrex CS-3 cesium magnetometer. In the northern part of the survey area, data improve the magnetic resolution of the individual domes and coulees along Mono Craters and a circular shaped magnetic anomaly that coincides with a poorly defined ring fracture mapped by Kistler (1966). Here, aeromagnetic data combined with other geophysical data suggests that Mono Craters may have preferentially followed a pre-existing plutonic basement feature that may have controlled the sickle shape of the volcanic chain. In the northeastern part of the survey, aeromagnetic data reveal a linear magnetic anomaly that correlates with and extends a mapped fault. In the southern part of the survey, in the Sierra Nevada block just south of Long Valley Caldera, aeromagnetic anomalies correlate with NNW-trending Sierran frontal faults rather than to linear NNE-trends observed in recent seismicity over the last 30 years. These data provide an important framework for the further analysis of the

Prevalence, Risk Factors, and Treatment Outcomes of Isoniazid- and Rifampicin-Mono-Resistant Pulmonary Tuberculosis in Lima, Peru.

Directory of Open Access Journals (Sweden)

Leonela Villegas

Full Text Available Isoniazid and rifampicin are the two most efficacious first-line agents for tuberculosis (TB treatment. We assessed the prevalence of isoniazid and rifampicin mono-resistance, associated risk factors, and the association of mono-resistance on treatment outcomes.A prospective, observational cohort study enrolled adults with a first episode of smear-positive pulmonary TB from 34 health facilities in a northern district of Lima, Peru, from March 2010 through December 2011. Participants were interviewed and a sputum sample was cultured on Löwenstein-Jensen (LJ media. Drug susceptibility testing was performed using the proportion method. Medication regimens were documented for each patient. Our primary outcomes were treatment outcome at the end of treatment. The secondary outcome included recurrent episodes among cured patients within two years after completion of the treatment.Of 1292 patients enrolled, 1039 (80% were culture-positive. From this subpopulation, isoniazid mono-resistance was present in 85 (8% patients and rifampicin mono-resistance was present in 24 (2% patients. In the multivariate logistic regression model, isoniazid mono-resistance was associated with illicit drug use (adjusted odds ratio (aOR = 2.10; 95% confidence interval (CI: 1.1-4.1, and rifampicin mono-resistance was associated with HIV infection (aOR = 9.43; 95%CI: 1.9-47.8. Isoniazid mono-resistant patients had a higher risk of poor treatment outcomes including treatment failure (2/85, 2%, p-value<0.01 and death (4/85, 5%, p<0.02. Rifampicin mono-resistant patients had a higher risk of death (2/24, 8%, p<0.01.A high prevalence of isoniazid and rifampicin mono-resistance was found among TB patients in our low HIV burden setting which were similar to regions with high HIV burden. Patients with isoniazid and rifampicin mono-resistance had an increased risk of poor treatment outcomes.

Modification and performance evaluation of a mono-valve engine

Science.gov (United States)

Behrens, Justin W.

A four-stroke engine utilizing one tappet valve for both the intake and exhaust gas exchange processes has been built and evaluated. The engine operates under its own power, but has a reduced power capacity than the conventional 2-valve engine. The reduction in power is traced to higher than expected amounts of exhaust gases flowing back into the intake system. Design changes to the cylinder head will fix the back flow problems, but the future capacity of mono-valve engine technology cannot be estimated. The back flow of exhaust gases increases the exhaust gas recirculation (EGR) rate and deteriorates combustion. Intake pressure data shows the mono-valve engine requires an advanced intake valve closing (IVC) time to prevent back flow of charge air. A single actuation camshaft with advanced IVC was tested in the mono-valve engine, and was found to improve exhaust scavenging at TDC and nearly eliminated all charge air back flow at IVC. The optimum IVC timing is shown to be approximately 30 crank angle degrees after BDC. The mono-valve cylinder head utilizes a rotary valve positioned above the tappet valve. The open spaces inside the rotary valveand between the rotary valve and tappet valve represent a common volume that needs to be reduced in order to reduce the base EGR rate. Multiple rotary valve configurations were tested, and the size of the common volume was found to have no effect on back flow but a direct effect on the EGR rate and engine performance. The position of the rotary valve with respect to crank angle has a direct effect on the scavenging process. Optimum scavenging occurs when the intake port is opened just after TDC.

Method for separating mono- and di-octylphenyl phosphoric acid esters

International Nuclear Information System (INIS)

Arnold, W.D. Jr.

1977-01-01

A method for separating mono-octylphenyl phosphoric acid ester and di-octylphenyl phosphoric acid ester from a mixture thereof comprises reacting the ester mixture with a source of lithium or sodium ions to form a mixture of the phosphate salts; contacting the salt mixture with an organic solvent which causes the dioctylphenyl phosphate salt to be dissolved in the organic solvent phase and the mono-octylphenyl phosphate salt to exist in a solid phase; separating the phases; recovering the phosphate salts from their respective phases; and acidifying the recovered salts to form the original phosphoric acid esters

Tubes, Mono Jets, Squeeze Out and CME

Energy Technology Data Exchange (ETDEWEB)

Longacre, R. [Brookhaven National Lab. (BNL), Upton, NY (United States)

2017-10-23

Glasma Flux Tubes, Mono Jets with squeeze out flow around them plus the Chiral Magnetic Effect(CME) are physical phenomenon that generate two particle correlation with respect to the reaction plane in mid-central 20% to 30% Au-Au collision √sNN = 200.0 GeV measured at RHIC.

Imaging the magmatic system of Mono Basin, California with magnetotellurics in three--dimensions

Science.gov (United States)

Peacock, Jared R.; Mangan, Margaret T.; McPhee, Darcy K.; Ponce, David A.

2015-01-01

A three–dimensional (3D) electrical resistivity model of Mono Basin in eastern California unveils a complex subsurface filled with zones of partial melt, fluid–filled fracture networks, cold plutons, and regional faults. In 2013, 62 broadband magnetotelluric (MT) stations were collected in an array around southeastern Mono Basin from which a 3D electrical resistivity model was created with a resolvable depth of 35 km. Multiple robust electrical resistivity features were found that correlate with existing geophysical observations. The most robust features are two 300 ± 50 km3 near-vertical conductive bodies (3–10 Ω·m) that underlie the southeast and north-eastern margin of Mono Craters below 10 km depth. These features are interpreted as magmatic crystal–melt mush zones of 15 ± 5% interstitial melt surrounded by hydrothermal fluids and are likely sources for Holocene eruptions. Two conductive east–dipping structures appear to connect each magma source region to the surface. A conductive arc–like structure (resistivity (200 Ω·m) suggestive of a cooled connection. A third, less constrained conductive feature (4–10 Ω·m) 15 km deep extending to 35 km is located west of Mono Craters near the eastern front of the Sierra Nevada escarpment, and is coincident with a zone of sporadic, long–period earthquakes that are characteristic of a fluid-filled (magmatic or metamorphic) fracture network. A resistive feature (103–105 Ω·m) located under Aeolian Buttes contains a deep root down to 25 km. The eastern edge of this resistor appears to structurally control the arcuate shape of Mono Craters. These observations have been combined to form a new conceptual model of the magmatic system beneath Mono Craters to a depth of 30 km.

[Technique of complex mammary irradiation: Mono-isocentric 3D conformational radiotherapy and helical tomotherapy].

Science.gov (United States)

Vandendorpe, B; Guilbert, P; Champagne, C; Antoni, T; Nguyen, T D; Gaillot-Petit, N; Servagi Vernat, S

2017-12-01

To evaluate the dosimetric contribution of helical tomotherapy for breast cancers compared with conformal radiotherapy in mono-isocentric technique. For 23 patients, the dosimetric results in mono-isocentric 3D conformational radiotherapy did not satisfy the constraints either of target volumes nor organs at risk. A prospective dosimetric comparison between mono-isocentric 3D conformational radiotherapy and helical tomotherapy was therefore carried out. The use of helical tomotherapy showed a benefit in these 23 patients, with either an improvement in the conformity index or homogeneity, but with an increase in low doses. Of the 23 patients, two had pectus excavatum, five had past thoracic irradiation and two required bilateral irradiation. The other 14 patients had a combination of morphology and/or indication of lymph node irradiation. For these patients, helical tomotherapy was therefore preferred to mono-isocentric 3D conformational radiotherapy. Tomotherapy appears to provide better homogeneity and tumour coverage. This technique of irradiation may be justified in the case of morphological situations such as pectus exavatum and in complex clinical situations. In other cases, conformal radiotherapy in mono-isocentric technique remains to be favoured. Copyright © 2017 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

Cost-Effective Mass Production of Mono Bucket Foundations

DEFF Research Database (Denmark)

Gres, Szymon; Nielsen, Søren Andreas; Fejerskov, Morten

2015-01-01

for innovative and cost-effective design of Mono Bucket foundations. Established approach merges wind and wave load models, soil/structure interaction topics, structural optimization and installation/fabrication aspects, into software package with ability to perform optimal design of the individual foundations...

Selective mono-radioiodination and characterization of a cell-penetrating peptide. L-Tyr-maurocalcine

Energy Technology Data Exchange (ETDEWEB)

Ahmadi, Mitra; Bacot, Sandrine; Perret, Pascale; Riou, Laurent; Ghezzi, Catherine [Universite Joseph Fourier, Grenoble (France); INSERM U1039, Grenoble (France). Radiopharmaceutiques Biocliniques; Poillot, Cathy; Cestele, Sandrine [INSERM U836, Grenoble (France). Grenoble Inst. of Neuroscience; Universite Joseph Fourier, Grenoble (France); Desruet, Marie-Dominique [INSERM U1039, Grenoble (France). Radiopharmaceutiques Biocliniques; Couvet, Morgane; Bourgoin, Sandrine; Seve, Michel [CRI-INSERM U823, Grenoble (France). Inst. of Albert Bonniot; Universite Joseph Fourier, Grenoble (France); Waard, Michel de [INSERM U836, Grenoble (France). Grenoble Inst. of Neuroscience; Universite Joseph Fourier, Grenoble (France); Smartox Biotechnologies, Grenoble (France)

2014-07-01

Mono-and poly-iodinated peptides form frequently during radioiodination procedures. However, the formation of a single species in its mono-iodinated form is essential for quantitative studies such as determination of tissue concentration or image quantification. Therefore, the aim of the present study was to define the optimal experimental conditions in order to exclusively obtain the mono-iodinated form of L-maurocalcine (L-MCa). L-MCa is an animal venom toxin which was shown to act as a cell-penetrating peptide. In order to apply the current direct radioiodination technique using oxidative agents including chloramine T, Iodo-Gen {sup registered} or lactoperoxidase, an analogue of this peptide containing a tyrosine residue (Tyr-L-MCa) was synthesized and was shown to fold/oxidize properly. The enzymatic approach using lactoperoxidase/H{sub 2}O{sub 2} was found to be the best method for radioiodination of Tyr-L-MCa. MALDI-TOF mass spectrometry analyses were then used for identification of the chromatographic eluting components of the reaction mixtures. We observed that the production of different radioiodinated species depended upon the reaction conditions. Our results successfully described the experimental conditions of peptide radioiodination allowing the exclusive production of the mono-iodinated form with high radiochemical purity and without the need for a purification step. Mono-radioiodination of L-Tyr-MCa will be crucial for future quantitative studies, investigating the mechanism of cell penetration and in vivo biodistribution.

21 CFR 582.4505 - Mono- and diglycerides of edible fats or oils, or edible fat-forming acids.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Mono- and diglycerides of edible fats or oils, or... GENERALLY RECOGNIZED AS SAFE Emulsifying Agents § 582.4505 Mono- and diglycerides of edible fats or oils, or edible fat-forming acids. (a) Product. Mono- and diglycerides of edible fats or oils, or edible fat...

Emotions in freely varying and mono-pitched vowels, acoustic and EGG analyses.

Science.gov (United States)

Waaramaa, Teija; Palo, Pertti; Kankare, Elina

2015-12-01

Vocal emotions are expressed either by speech or singing. The difference is that in singing the pitch is predetermined while in speech it may vary freely. It was of interest to study whether there were voice quality differences between freely varying and mono-pitched vowels expressed by professional actors. Given their profession, actors have to be able to express emotions both by speech and singing. Electroglottogram and acoustic analyses of emotional utterances embedded in expressions of freely varying vowels [a:], [i:], [u:] (96 samples) and mono-pitched protracted vowels (96 samples) were studied. Contact quotient (CQEGG) was calculated using 35%, 55%, and 80% threshold levels. Three different threshold levels were used in order to evaluate their effects on emotions. Genders were studied separately. The results suggested significant gender differences for CQEGG 80% threshold level. SPL, CQEGG, and F4 were used to convey emotions, but to a lesser degree, when F0 was predetermined. Moreover, females showed fewer significant variations than males. Both genders used more hypofunctional phonation type in mono-pitched utterances than in the expressions with freely varying pitch. The present material warrants further study of the interplay between CQEGG threshold levels and formant frequencies, and listening tests to investigate the perceptual value of the mono-pitched vowels in the communication of emotions.

Air quality in bedded mono-slope beef barns

Science.gov (United States)

Bedded mono-slope barns are becoming more common in the upper Midwest. Because these are new facilities, little research has been published regarding environmental quality, building management and animal performance in these facilities. A team of researchers from South Dakota State University, USDA ...

Long-term thermophilic mono-digestion of rendering wastes and co-digestion with potato pulp

International Nuclear Information System (INIS)

Bayr, S.; Ojanperä, M.; Kaparaju, P.; Rintala, J.

2014-01-01

Highlights: • Rendering wastes’ mono-digestion and co-digestion with potato pulp were studied. • CSTR process with OLR of 1.5 kg VS/m 3 d, HRT of 50 d was unstable in mono-digestion. • Free NH 3 inhibited mono-digestion of rendering wastes. • CSTR process with OLR of 1.5 kg VS/m 3 d, HRT of 50 d was stable in co-digestion. • Co-digestion increased methane yield somewhat compared to mono-digestion. - Abstract: In this study, mono-digestion of rendering wastes and co-digestion of rendering wastes with potato pulp were studied for the first time in continuous stirred tank reactor (CSTR) experiments at 55 °C. Rendering wastes have high protein and lipid contents and are considered good substrates for methane production. However, accumulation of digestion intermediate products viz., volatile fatty acids (VFAs), long chain fatty acids (LCFAs) and ammonia nitrogen (NH 4 -N and/or free NH 3 ) can cause process imbalance during the digestion. Mono-digestion of rendering wastes at an organic loading rate (OLR) of 1.5 kg volatile solids (VS)/m 3 d and hydraulic retention time (HRT) of 50 d was unstable and resulted in methane yields of 450 dm 3 /kg VS fed . On the other hand, co-digestion of rendering wastes with potato pulp (60% wet weight, WW) at the same OLR and HRT improved the process stability and increased methane yields (500–680 dm 3 /kg VS fed ). Thus, it can be concluded that co-digestion of rendering wastes with potato pulp could improve the process stability and methane yields from these difficult to treat industrial waste materials

Studies of mono-crystalline CVD diamond pixel detectors

CERN Document Server

Bartz, E; Atramentov, O; Yang, Z; Hall-Wilton, R; Schnetzer, S; Patel, R; Bugg, W; Hebda, P; Halyo, V; Hunt, A; Marlow, D; Steininger, H; Ryjov, V; Hits, D; Spanier, S; Pernicka, M; Johns, W; Doroshenko, J; Hollingsworth, M; Harrop, B; Farrow, C; Stone, R

2011-01-01

The Pixel Luminosity Telescope (PLT) is a dedicated luminosity monitor, presently under construction, for the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC). It measures the particle flux in several three layered pixel diamond detectors that are aligned precisely with respect to each other and the beam direction. At a lower rate it also performs particle track position measurements. The PLTs mono-crystalline CVD diamonds are bump-bonded to the same readout chip used in the silicon pixel system in CMS. Mono-crystalline diamond detectors have many attributes that make them desirable for use in charged particle tracking in radiation hostile environments such as the LHC. In order to further characterize the applicability of diamond technology to charged particle tracking we performed several tests with particle beams that included a measurement of the intrinsic spatial resolution with a high resolution beam telescope. Published by Elsevier B.V.

Studies of mono-crystalline CVD diamond pixel detectors

Energy Technology Data Exchange (ETDEWEB)

Bugg, W. [University of Tennessee, Knoxville (United States); Hollingsworth, M., E-mail: mhollin3@utk.edu [University of Tennessee, Knoxville (United States); Spanier, S.; Yang, Z. [University of Tennessee, Knoxville (United States); Bartz, E.; Doroshenko, J.; Hits, D.; Schnetzer, S.; Stone, R.; Atramentov, O.; Patel, R.; Barker, A. [Rutgers University, Piscataway (United States); Hall-Wilton, R.; Ryjov, V.; Farrow, C. [CERN, Geneva (Switzerland); Pernicka, M.; Steininger, H. [HEPHY, Vienna (Austria); Johns, W. [Vanderbilt University, Nashville (United States); Halyo, V.; Harrop, B. [Princeton University, Princeton (United States); and others

2011-09-11

The Pixel Luminosity Telescope (PLT) is a dedicated luminosity monitor, presently under construction, for the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC). It measures the particle flux in several three layered pixel diamond detectors that are aligned precisely with respect to each other and the beam direction. At a lower rate it also performs particle track position measurements. The PLT's mono-crystalline CVD diamonds are bump-bonded to the same readout chip used in the silicon pixel system in CMS. Mono-crystalline diamond detectors have many attributes that make them desirable for use in charged particle tracking in radiation hostile environments such as the LHC. In order to further characterize the applicability of diamond technology to charged particle tracking we performed several tests with particle beams that included a measurement of the intrinsic spatial resolution with a high resolution beam telescope.

Mono and bimetallic nanoparticles of gold, silver and palladium-catalyzed NADH oxidation-coupled reduction of Eosin-Y

Science.gov (United States)

Santhanalakshmi, J.; Venkatesan, P.

2011-02-01

Mono metallic (Au, Ag, Pd) and bimetallic (Au-Ag, Ag-Pd, Au-Pd) with 1:1 mol stoichiometry, nanoparticles are synthesized using one-pot, temperature controlled chemical method using cetyltrimethylammonium bromide (CTAB) as the capping agent. The particle sizes (Au = 5.6, Ag = 5.0, Pd = 6.0, Au-Ag = 9.2, Ag-Pd = 9.6, Au-Pd = 9.4 nm) are characterized by UV-Vis, HRTEM, and XRD measurements, respectively. CTAB bindings onto mono and bimetallic nanoparticles are analyzed by FTIR spectra. The catalytic activities of mono and bimetallic nanoparticles are tested on the reaction between NADH oxidation and Eosin-Y reduction. The effects of base, pH, ionic strength, nature of mono and bimetallic catalysts are studied and the reaction conditions are optimized. Bimetallic nanoparticles exhibited better catalysis than the mono metallic nanoparticles, which may be due to the electronic effects of the core to shell metal atoms.

Long-term thermophilic mono-digestion of rendering wastes and co-digestion with potato pulp

Energy Technology Data Exchange (ETDEWEB)

Bayr, S., E-mail: suvi.bayr@jyu.fi; Ojanperä, M.; Kaparaju, P.; Rintala, J.

2014-10-15

Highlights: • Rendering wastes’ mono-digestion and co-digestion with potato pulp were studied. • CSTR process with OLR of 1.5 kg VS/m{sup 3} d, HRT of 50 d was unstable in mono-digestion. • Free NH{sub 3} inhibited mono-digestion of rendering wastes. • CSTR process with OLR of 1.5 kg VS/m{sup 3} d, HRT of 50 d was stable in co-digestion. • Co-digestion increased methane yield somewhat compared to mono-digestion. - Abstract: In this study, mono-digestion of rendering wastes and co-digestion of rendering wastes with potato pulp were studied for the first time in continuous stirred tank reactor (CSTR) experiments at 55 °C. Rendering wastes have high protein and lipid contents and are considered good substrates for methane production. However, accumulation of digestion intermediate products viz., volatile fatty acids (VFAs), long chain fatty acids (LCFAs) and ammonia nitrogen (NH{sub 4}-N and/or free NH{sub 3}) can cause process imbalance during the digestion. Mono-digestion of rendering wastes at an organic loading rate (OLR) of 1.5 kg volatile solids (VS)/m{sup 3} d and hydraulic retention time (HRT) of 50 d was unstable and resulted in methane yields of 450 dm{sup 3}/kg VS{sub fed}. On the other hand, co-digestion of rendering wastes with potato pulp (60% wet weight, WW) at the same OLR and HRT improved the process stability and increased methane yields (500–680 dm{sup 3}/kg VS{sub fed}). Thus, it can be concluded that co-digestion of rendering wastes with potato pulp could improve the process stability and methane yields from these difficult to treat industrial waste materials.

1. Mono([8]annulene)Uranium(4) half-sandwich complexes, 2. Novel syntheses of symmetrically substituted cyclooctatetetraenes

International Nuclear Information System (INIS)

Boussie, T.R.

1991-10-01

A reproducible, high-yield synthesis of mono([8]annulene)uranium(4)dichloride (1) is reported, along with the X-ray crystal structural of the bis(pyridine) adduct. Metathesis reactions of the half-sandwich complex 1 with a variety of simple alkyl and alkoxy reagents failed to generate any isolable mono-ring complexes. Reactions of 1 with polydentate, delocalized anions did produce stable derivatives, including mono([8]annulene)uranium(4)bis(acetylacetonate) (4). An X-ray crystal structure of 4 is reported

1. Mono([8]annulene)Uranium(4) half-sandwich complexes, 2. Novel syntheses of symmetrically substituted cyclooctatetetraenes

Energy Technology Data Exchange (ETDEWEB)

Boussie, Thomas Richard [Univ. of California, Berkeley, CA (United States)

1991-10-01

A reproducible, high-yield synthesis of mono([8]annulene)uranium(4)dichloride (1) is reported, along with the X-ray crystal structural of the bis(pyridine) adduct. Metathesis reactions of the half-sandwich complex 1 with a variety of simple alkyl and alkoxy reagents failed to generate any isolable mono-ring complexes. Reactions of 1 with polydentate, delocalized anions did produce stable derivatives, including mono([8]annulene)uranium(4)bis(acetylacetonate) (4). An X-ray crystal structure of 4 is reported.

1. Mono((8)annulene)Uranium(4) half-sandwich complexes, 2. Novel syntheses of symmetrically substituted cyclooctatetetraenes

Energy Technology Data Exchange (ETDEWEB)

Boussie, T.R.

1991-10-01

A reproducible, high-yield synthesis of mono((8)annulene)uranium(4)dichloride (1) is reported, along with the X-ray crystal structural of the bis(pyridine) adduct. Metathesis reactions of the half-sandwich complex 1 with a variety of simple alkyl and alkoxy reagents failed to generate any isolable mono-ring complexes. Reactions of 1 with polydentate, delocalized anions did produce stable derivatives, including mono((8)annulene)uranium(4)bis(acetylacetonate) (4). An X-ray crystal structure of 4 is reported.

Mono and bimetallic nanoparticles of gold, silver and palladium-catalyzed NADH oxidation-coupled reduction of Eosin-Y

International Nuclear Information System (INIS)

Santhanalakshmi, J.; Venkatesan, P.

2011-01-01

Mono metallic (Au, Ag, Pd) and bimetallic (Au–Ag, Ag–Pd, Au–Pd) with 1:1 mol stoichiometry, nanoparticles are synthesized using one-pot, temperature controlled chemical method using cetyltrimethylammonium bromide (CTAB) as the capping agent. The particle sizes (Au = 5.6, Ag = 5.0, Pd = 6.0, Au–Ag = 9.2, Ag–Pd = 9.6, Au–Pd = 9.4 nm) are characterized by UV–Vis, HRTEM, and XRD measurements, respectively. CTAB bindings onto mono and bimetallic nanoparticles are analyzed by FTIR spectra. The catalytic activities of mono and bimetallic nanoparticles are tested on the reaction between NADH oxidation and Eosin-Y reduction. The effects of base, pH, ionic strength, nature of mono and bimetallic catalysts are studied and the reaction conditions are optimized. Bimetallic nanoparticles exhibited better catalysis than the mono metallic nanoparticles, which may be due to the electronic effects of the core to shell metal atoms.Graphical Abstract

Leptonic mono-top from single stop production at the LHC

Energy Technology Data Exchange (ETDEWEB)

Duan, Guang Hua [CAS Key Laboratory of Theoretical Physics, Institute of Theoretical Physics,Chinese Academy of Sciences,Beijing 100190 (China); Hikasa, Ken-ichi [Department of Physics, Tohoku University,Sendai 980-8578 (Japan); Wu, Lei [Department of Physics and Institute of Theoretical Physics, Nanjing Normal University,Nanjing, Jiangsu 210023 (China); ARC Centre of Excellence for Particle Physics at the Terascale,School of Physics, The University of Sydney,NSW 2006 (Australia); Yang, Jin Min [CAS Key Laboratory of Theoretical Physics, Institute of Theoretical Physics,Chinese Academy of Sciences,Beijing 100190 (China); Department of Physics, Tohoku University,Sendai 980-8578 (Japan); Zhang, Mengchao [Center for Theoretical Physics and Universe, Institute for Basic Science (IBS),Daejeon 34051 (Korea, Republic of)

2017-03-16

Top squark (stop) can be produced via QCD interaction but also the electroweak interaction at the LHC. In this paper, we investigate the observability of the associated production of stop and chargino, pp→t̃{sub 1}χ̃{sub 1}{sup −}, in compressed electroweakino scenarios at 14 TeV LHC. Due to small mass splitting between the lightest neutralino (χ̃{sub 1}{sup 0}) and chargino (χ̃{sub 1}{sup −}), the single stop production can give the mono-top signature through the stop decay t̃{sub 1}→tχ̃{sub 1}{sup 0}. We analyze the leptonic mono-top channel of the single stop production and propose a lab-frame observable cos θ{sub bℓ} to reduce the SM backgrounds. We find that such leptonic mono-top events from the single stop production can be probed at 2σ level at the HL-LHC if m{sub t̃{sub 1}}<760 GeV and m{sub χ̃{sub 1{sup 0}}}<150 GeV. Given a discovery of the stop and a measurement of the single stop production cross section, the stop mixing angle can also be determined from the single stop production at the HL-LHC.

Seasonality of cavitation and frost fatigue in Acer mono Maxim.

Science.gov (United States)

Zhang, Wen; Feng, Feng; Tyree, Melvin T

2017-12-08

Although cavitation is common in plants, it is unknown whether the cavitation resistance of xylem is seasonally constant or variable. We tested the changes in cavitation resistance of Acer mono before and after a controlled cavitation-refilling and freeze-thaw cycles for a whole year. Cavitation resistance was determined from 'vulnerability curves' showing the percent loss of conductivity versus xylem tension. Cavitation fatigue was defined as a reduction of cavitation resistance following a cavitation-refilling cycle, whereas frost fatigue was caused by a freeze-thaw cycle. A. mono developed seasonal changes in native embolisms; values were relatively high during winter but relatively low and constant throughout the growing season. Cavitation fatigue occurred and changed seasonally during the 12-month cycle; the greatest fatigue response occurred during summer and the weakest during winter, and the transitions occurred during spring and autumn. A. mono was highly resistant to frost damage during the relatively mild winter months; however, a quite different situation occurred during the growing season, as the seasonal trend of frost fatigue was strikingly similar to that of cavitation fatigue. Seasonality changes in cavitation resistance may be caused by seasonal changes in the mechanical properties of the pit membranes. © 2017 John Wiley & Sons Ltd.

Mono- and binuclear complexes of low-valent zirconium

NARCIS (Netherlands)

Wielstra, IJtsen

1990-01-01

This thesis is a study on the synthesis and reactivity of low-valent zirconium. The investigation can be divided in two parts: the first describes the chemistry of mono-cyclopentadienyl Zr (II) complexes (Chapter II, III and IV), and the second describes some synthetic pathways successfully used for

MonoSLAM: real-time single camera SLAM.

Science.gov (United States)

Davison, Andrew J; Reid, Ian D; Molton, Nicholas D; Stasse, Olivier

2007-06-01

We present a real-time algorithm which can recover the 3D trajectory of a monocular camera, moving rapidly through a previously unknown scene. Our system, which we dub MonoSLAM, is the first successful application of the SLAM methodology from mobile robotics to the "pure vision" domain of a single uncontrolled camera, achieving real time but drift-free performance inaccessible to Structure from Motion approaches. The core of the approach is the online creation of a sparse but persistent map of natural landmarks within a probabilistic framework. Our key novel contributions include an active approach to mapping and measurement, the use of a general motion model for smooth camera movement, and solutions for monocular feature initialization and feature orientation estimation. Together, these add up to an extremely efficient and robust algorithm which runs at 30 Hz with standard PC and camera hardware. This work extends the range of robotic systems in which SLAM can be usefully applied, but also opens up new areas. We present applications of MonoSLAM to real-time 3D localization and mapping for a high-performance full-size humanoid robot and live augmented reality with a hand-held camera.

Single-step brazing process for mono-block joints and mechanical testing

Energy Technology Data Exchange (ETDEWEB)

Casalegno, V.; Ferraris, M.; Salvo, M.; Rizzo, S. [Politecnico di Torino, Materials Science and Chemical Engineering Dept., Torino (Italy); Merola, M. [ITER International Team, llER Joint Work Site, Cadarache, 13 - St Paul Lez Durance (France)

2007-07-01

Full text of publication follows: Plasma facing components act as actively cooled thermal shields to sustain thermal and particle loads during normal and transient operations in ITER (International Thermonuclear Experimental Reactor). The plasma-facing layer is referred to as 'armour', which is made of either carbon fibre reinforced carbon composite (CFC) or tungsten (W). CFC is the reference design solution for the lower part of the vertical target of the ITER divertor. The armour is joined onto an actively cooled substrate, the heat sink, made of precipitation hardened copper alloy CuCrZr through a thin pure copper interlayer to decrease, by plastic deformation, the joint interface stresses; in fact, the CFC to Cu joint is affected by the CTE mismatch between the ceramic and metallic material. A new method of joining CFC to copper and CFC/Cu to CuCrZr alloy was effectively developed for the flat-type configuration; the feasibility of this process also for mono-block geometry and the development of a procedure for testing mono-block-type mock-ups is described in this work. The mono-block configuration consists of copper alloy pipe shielded by CFC blocks. It is worth noting that in mono-block configuration, the large thermal expansion mismatch between CFC and copper alloy is more significant than for flat-tile configuration, due to curved interfaces. The joining technique foresees a single-step brazing process: the brazing of the three materials (CFC-Cu-CuCrZr) can be performed in a single heat treatment using the same Cu/Ge based braze. The composite surface was modified by solid state reaction with chromium with the purpose of increasing the wettability of CFC by the brazing alloy. The CFC substrate reacts with Cr which, forming a carbide layer, allows a large reduction of the contact angle; then, the brazing of CFC to pure copper and pure copper to CuCrZr by the same treatment is feasible. This process allows to obtain good joints using a non

Single-step brazing process for mono-block joints and mechanical testing

International Nuclear Information System (INIS)

Casalegno, V.; Ferraris, M.; Salvo, M.; Rizzo, S.; Merola, M.

2007-01-01

Full text of publication follows: Plasma facing components act as actively cooled thermal shields to sustain thermal and particle loads during normal and transient operations in ITER (International Thermonuclear Experimental Reactor). The plasma-facing layer is referred to as 'armour', which is made of either carbon fibre reinforced carbon composite (CFC) or tungsten (W). CFC is the reference design solution for the lower part of the vertical target of the ITER divertor. The armour is joined onto an actively cooled substrate, the heat sink, made of precipitation hardened copper alloy CuCrZr through a thin pure copper interlayer to decrease, by plastic deformation, the joint interface stresses; in fact, the CFC to Cu joint is affected by the CTE mismatch between the ceramic and metallic material. A new method of joining CFC to copper and CFC/Cu to CuCrZr alloy was effectively developed for the flat-type configuration; the feasibility of this process also for mono-block geometry and the development of a procedure for testing mono-block-type mock-ups is described in this work. The mono-block configuration consists of copper alloy pipe shielded by CFC blocks. It is worth noting that in mono-block configuration, the large thermal expansion mismatch between CFC and copper alloy is more significant than for flat-tile configuration, due to curved interfaces. The joining technique foresees a single-step brazing process: the brazing of the three materials (CFC-Cu-CuCrZr) can be performed in a single heat treatment using the same Cu/Ge based braze. The composite surface was modified by solid state reaction with chromium with the purpose of increasing the wettability of CFC by the brazing alloy. The CFC substrate reacts with Cr which, forming a carbide layer, allows a large reduction of the contact angle; then, the brazing of CFC to pure copper and pure copper to CuCrZr by the same treatment is feasible. This process allows to obtain good joints using a non-active brazing

Tritium enrichment from aqueous solutions using cryosublimation of mono- and polysaccharides

International Nuclear Information System (INIS)

Wierczinski, B.; Muellen, G.; Rosenhauer, S.

2008-01-01

Cryosublimation is one technique, which allows the accumulation of tritium from aqueous solutions using certain chemical compounds. After studying several inorganic compounds such as zeolites and metal salts, as well as some humic substances, we have now investigated several mono- and polysaccharides, such as glucose, maltose, galactose, starch, agar, and gelatine. Except for starch all of the above mentioned compounds showed a clear enrichment of tritium. The highest value was reached for Agartine, which gave an enrichment factor of 6.2. Since mono- and polysaccharides form weak hydrogen bonds, these results prove again our theory that tritium is preferably accumulated in exchangeable hydrogen bonds. (author)

Separation of type and grade in cervical tumours using non-mono-exponential models of diffusion-weighted MRI

International Nuclear Information System (INIS)

Winfield, Jessica M.; Collins, David J.; Morgan, Veronica A.; DeSouza, Nandita M.; Orton, Matthew R.; Ind, Thomas E.J.; Attygalle, Ayoma; Hazell, Steve

2017-01-01

Assessment of empirical diffusion-weighted MRI (DW-MRI) models in cervical tumours to investigate whether fitted parameters distinguish between types and grades of tumours. Forty-two patients (24 squamous cell carcinomas, 14 well/moderately differentiated, 10 poorly differentiated; 15 adenocarcinomas, 13 well/moderately differentiated, two poorly differentiated; three rare types) were imaged at 3 T using nine b-values (0 to 800 s mm -2 ). Mono-exponential, stretched exponential, kurtosis, statistical, and bi-exponential models were fitted. Model preference was assessed using Bayesian Information Criterion analysis. Differences in fitted parameters between tumour types/grades and correlation between fitted parameters were assessed using two-way analysis of variance and Pearson's linear correlation coefficient, respectively. Non-mono-exponential models were preferred by 83 % of tumours with bi-exponential and stretched exponential models preferred by the largest numbers of tumours. Apparent diffusion coefficient (ADC) and diffusion coefficients from non-mono-exponential models were significantly lower in poorly differentiated tumours than well/moderately differentiated tumours. α (stretched exponential), K (kurtosis), f and D* (bi-exponential) were significantly different between tumour types. Strong correlation was observed between ADC and diffusion coefficients from other models. Non-mono-exponential models were preferred to the mono-exponential model in DW-MRI data from cervical tumours. Parameters of non-mono-exponential models showed significant differences between types and grades of tumours. (orig.)

Separation of type and grade in cervical tumours using non-mono-exponential models of diffusion-weighted MRI

Energy Technology Data Exchange (ETDEWEB)

Winfield, Jessica M.; Collins, David J.; Morgan, Veronica A.; DeSouza, Nandita M. [The Royal Marsden NHS Foundation Trust, MRI Unit, Sutton, Surrey (United Kingdom); The Institute of Cancer Research, Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, London (United Kingdom); Orton, Matthew R. [The Institute of Cancer Research, Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, London (United Kingdom); Ind, Thomas E.J. [The Royal Marsden NHS Foundation Trust, Gynaecology Unit, London (United Kingdom); Attygalle, Ayoma; Hazell, Steve [The Royal Marsden NHS Foundation Trust, Department of Histopathology, London (United Kingdom)

2017-02-15

Assessment of empirical diffusion-weighted MRI (DW-MRI) models in cervical tumours to investigate whether fitted parameters distinguish between types and grades of tumours. Forty-two patients (24 squamous cell carcinomas, 14 well/moderately differentiated, 10 poorly differentiated; 15 adenocarcinomas, 13 well/moderately differentiated, two poorly differentiated; three rare types) were imaged at 3 T using nine b-values (0 to 800 s mm{sup -2}). Mono-exponential, stretched exponential, kurtosis, statistical, and bi-exponential models were fitted. Model preference was assessed using Bayesian Information Criterion analysis. Differences in fitted parameters between tumour types/grades and correlation between fitted parameters were assessed using two-way analysis of variance and Pearson's linear correlation coefficient, respectively. Non-mono-exponential models were preferred by 83 % of tumours with bi-exponential and stretched exponential models preferred by the largest numbers of tumours. Apparent diffusion coefficient (ADC) and diffusion coefficients from non-mono-exponential models were significantly lower in poorly differentiated tumours than well/moderately differentiated tumours. α (stretched exponential), K (kurtosis), f and D* (bi-exponential) were significantly different between tumour types. Strong correlation was observed between ADC and diffusion coefficients from other models. Non-mono-exponential models were preferred to the mono-exponential model in DW-MRI data from cervical tumours. Parameters of non-mono-exponential models showed significant differences between types and grades of tumours. (orig.)

Behavioral ecology of American Pikas (Ochotona princeps) at Mono Craters, California: living on the edge

Science.gov (United States)

Andrew T. Smith; John D. Nagy; Connie Millar

2016-01-01

The behavioral ecology of the American pika (Ochotona princeps) was investigated at a relatively hot south-facing, low-elevation site in the Mono Craters, California, a habitat quite different from the upper montane regions more typically inhabited by this species and where most prior investigations have been conducted. Mono Craters pikas exhibited...

On the positron-trapping states of metal mono-vacancies

International Nuclear Information System (INIS)

Sankar, S.; Iyakutti, K.

1987-07-01

A model calculation based on the static dielectric screening theory has been performed to estimate the probable number of positron-trapping levels in metal mono-vacancies and it is shown that there cannot be more than one. (author). 8 refs, 1 tab

New thiol-responsive mono-cleavable block copolymer micelles labeled with single disulfides.

Science.gov (United States)

Sourkohi, Behnoush Khorsand; Schmidt, Rolf; Oh, Jung Kwon

2011-10-18

Thiol-responsive symmetric triblock copolymers having single disulfide linkages in the middle blocks (called mono-cleavable block copolymers, ss-ABP(2)) were synthesized by atom transfer radical polymerization in the presence of a disulfide-labeled difunctional Br-initiator. These brush-like triblock copolymers consist of a hydrophobic polyacrylate block having pendent oligo(propylene oxide) and a hydrophilic polymethacrylate block having pendent oligo(ethylene oxide). Gel permeation chromatography and (1)H NMR results confirmed the synthesis of well-defined mono-cleavable block copolymers and revealed that polymerizations were well controlled. Because of amphiphilic nature, these copolymers self-assembled to form colloidally stable micelles above critical micellar concentration of 0.032 mg · mL(-1). In response to reductive reactions, disulfides in thiol-responsive micelles were cleaved. Atomic force microscopy and dynamic light scattering analysis suggested that the cleavage of disulfides caused dissociation of micelles to smaller-sized assembled structures in water. Moreover, in a biomedical perspective, the mono-cleavable block copolymer micelles are not cytotoxic and thus biocompatible. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Two coarse pyroclastic flow deposits, northern Mono-Inyo Craters, CA

Science.gov (United States)

Dennen, R. L.; Bursik, M. I.; Stokes, P. J.; Lagamba, M.; Fontanella, N.; Hintz, A. R.; Jayko, A. S.

2010-12-01

The ~1350 A.D., rhyolitic North Mono eruption, Mono-Inyo Craters, CA, included the extrusion and destruction of Panum Dome and associated clastic deposits. Overlying the tephras of the North Mono sequence, the Panum deposits include a block-and-ash flow (BAF) deposit, covering ~3.5 km2. Blocks within the deposit are typically lithic rhyolite and banded gray micro-vesicular glass, showing white, almost powdery marks ranging from circular to linear in shape. These marks are interpreted as friction marks resulting from collisions between clasts. The deposit also contains bread-crusted obsidians with pressed-in clasts as well as reticulite with a bread-crusted surface texture. Near the centerline of the deposit is a ridge-topping train of jigsaw fractured blocks, often with reddish-orange alteration. One house sized jigsaw block sits upstream of a long, thinning pile of reddish orange debris; this “flow shadow” indicates that the block remained relatively stationary while the block and ash flow continued to propagate around it. The bread-crusted reticulite is most common at proximal localities. It is proposed that the dome destruction included a debris avalanche emplacing the train of jigsaw fractured blocks and creating a topographic high, the block-and-ash flow (the farthest reaching deposit from this event) which flowed around the debris avalanche deposits, and a final “lateral expansion” of a magma foam, creating the reticulite seen concentrated at proximal locations. Another coarse pyroclastic flow (here termed the “lower blast deposit”) underlies the North Mono tephra. It is more obsidian rich and finer grained than the Panum BAF. The lower blast deposit may have originated from Pumice Pit vent, which is now capped with an older dome ~0.5 km southeast of Panum. The lower blast deposit extends farther from the Panum vent than does the Panum BAF deposit, and apparently was mistaken for the Panum BAF deposit by previous workers. Hence the run

Geothermal systems of the Mono Basin-Long Valley region, eastern California and western Nevada

Energy Technology Data Exchange (ETDEWEB)

Higgins, C.T.; Flynn, T.; Chapman, R.H.; Trexler, D.T.; Chase, G.R.; Bacon, C.F.; Ghusn, G. Jr.

1985-01-01

The region that includes Mono Basin, Long Valley, the Bridgeport-Bodie Hills area, and Aurora, in eastern California and western Nevada was studied to determine the possible causes and interactions of the geothermal anomalies in the Mono Basin-Long Valley region as a whole. A special goal of the study was to locate possible shallow bodies of magma and to determine their influence on the hydrothermal systems in the region. (ACR)

Aria de pixel: riprodutibilità aurática digitale Ar de pixel: reprodutibilidade aurática digital Pixel air: digital auratic reprodutibility

Directory of Open Access Journals (Sweden)

Mássimo Canevacci

2010-04-01

Full Text Available Il saggio parte dalla riflessione del testo Writing Culture di Clifford-Marcus. Dopo più di 20 anni, è possibile verificare come questa critica, anziché aprire verso il futuro, ha chiuso una fase della mono-scrittura etnografica basata sul concetto di retorica e autorità. Già nella metà degli anni '80 stavano nascendo forme compositive multi-linguistiche sperimentali che applicavano una "etnografia indisciplinata" a design, architettura, pubblicità, musica, cinema, web. Si apre la sfida per una università non solo basata su Facoltà territoriali. Diverse modalità di comunicare attraverso il digitale mescolano e sincretizzano le visioni dualistiche di Benjamin su aura e riproducibilità. La mia prospettiva finale è la riproducibilità auratica digitale.Este artigo parte da reflexão sobre o texto Culture de.i Clifford-Marcus. Após 20 anos de sua publicação, é possível verificar como a crítica feita por este autor fecou uma fase da mono-escritura etnográfica baseana no conceito de retórica e autoridade. Já na metade dos anos 80 estavam nascendo formas compositivas multi-linguísticas experimentais que aplicavam um "etnografia indisciplinada" ao design, arquitetura, publicidade, música, cinema, web, abrindo uma via para universidades não somente baseadas sobre faculdades territoriais. Diversas modalidades de comunicação são digitalmente mixadas, sincretizando o dualimsno de Benjamin sobre aura e repordutibilidade. A minha perspectiva final é a reprodutibilidade aurática digital.My essay starts from a reflection on Clifford-Marcus's Writing Culture. After more than 20 years, it is possible to verify that such a critique - instead of opening toward the future - was going to close to the traditional ethnographic writing based on rhetoric and authority. In the middle of the 80's, were spreading experimental compositive patterns, applying an "undisciplined ethnography" to design, architecture, advertising, music, cinema and web

Impact of temperature on performance of series and parallel connected mono-crystalline silicon solar cells

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Subhash Chander

2015-11-01

Full Text Available This paper presents a study on impact of temperature on the performance of series and parallel connected mono-crystalline silicon (mono-Si solar cell employing solar simulator. The experiment was carried out at constant light intensity 550 W/m2with cell temperature in the range 25–60 oC for single, series and parallel connected mono-Si solar cells. The performance parameters like open circuit voltage, maximum power, fill factor and efficiency are found to decrease with cell temperature while the short circuit current is observed to increase. The experimental results reveal that silicon solar cells connected in series and parallel combinations follow the Kirchhoff’s laws and the temperature has a significant effect on the performance parameters of solar cell.

Mono-fermentation of shea waste in anaerobic digesters - laboratory ...

African Journals Online (AJOL)

For the purpose of understanding the characteristics in performance of the shea waste and to provide the necessary input parameters towards the design of biogas plants, mono-fermentation as an option in anaerobic digestion for energy (methane) generation was investigated. Six horizontal reactors with a liquid volume of ...

The Effects of Operational Parameters on a Mono-wire Cutting System: Efficiency in Marble Processing

Science.gov (United States)

Yilmazkaya, Emre; Ozcelik, Yilmaz

2016-02-01

Mono-wire block cutting machines that cut with a diamond wire can be used for squaring natural stone blocks and the slab-cutting process. The efficient use of these machines reduces operating costs by ensuring less diamond wire wear and longer wire life at high speeds. The high investment costs of these machines will lead to their efficient use and reduce production costs by increasing plant efficiency. Therefore, there is a need to investigate the cutting performance parameters of mono-wire cutting machines in terms of rock properties and operating parameters. This study aims to investigate the effects of the wire rotational speed (peripheral speed) and wire descending speed (cutting speed), which are the operating parameters of a mono-wire cutting machine, on unit wear and unit energy, which are the performance parameters in mono-wire cutting. By using the obtained results, cuttability charts for each natural stone were created on the basis of unit wear and unit energy values, cutting optimizations were performed, and the relationships between some physical and mechanical properties of rocks and the optimum cutting parameters obtained as a result of the optimization were investigated.

Biofilm formation and disinfectant resistance of Salmonella sp. in mono- and dual-species with Pseudomonas aeruginosa.

Science.gov (United States)

Pang, X Y; Yang, Y S; Yuk, H G

2017-09-01

This study aimed to evaluate the biofilm formation and disinfectant resistance of Salmonella cells in mono- and dual-species biofilms with Pseudomonas aeruginosa, and to investigate the role of extracellular polymeric substances (EPS) in the protection of biofilms against disinfection treatment. The populations of Salmonella in mono- or dual-species biofilms with P. aeruginosa on stainless steel (SS) coupons were determined before and after exposure to commercial disinfectant, 50 μg ml -1 chlorine or 200 μg ml -1 Ecolab ® Whisper™ V (a blend of four effective quaternary ammonium compounds (QAC)). In addition, EPS amount from biofilms was quantified and biofilm structures were observed using scanning electron microscopy (SEM). Antagonistic interactions between Salmonella and P. aeruginosa resulted in lower planktonic population level of Salmonella, and lower density in dual-species biofilms compared to mono-species biofilms. The presence of P. aeruginosa significantly enhanced disinfectant resistance of S. Typhimurium and S. Enteritidis biofilm cells for 2 days, and led to an average of 50% increase in polysaccharides amount in dual-species biofilms than mono-species biofilms of Salmonella. Microscopy observation showed the presence of large microcolonies covered by EPS in dual-species biofilms but not in mono-species ones. The presence of P. aeruginosa in dual-species culture inhibited the growth of Salmonella cells in planktonic phase and in biofilms, but protected Salmonella cells in biofilms from disinfection treatment, by providing more production of EPS in dual-species biofilms than mono-species ones. This study provides insights into inter-species interaction, with regard to biofilm population dynamics and disinfectant resistance. Thus, a sanitation protocol should be designed considering the protective role of secondary species to pathogens in biofilms on SS surface which has been widely used at food surfaces and manufacturers. © 2017 The Society

Dynamics of biogeochemical sulfur cycling in Mono Lake

Science.gov (United States)

Phillips, A. A.; Fairbanks, D.; Wells, M.; Fullerton, K. M.; Bao, R.; Johnson, H.; Speth, D. R.; Stamps, B. W.; Miller, L.; Sessions, A. L.

2017-12-01

Mono Lake, California is a closed-basin soda lake (pH 9.8) with high sulfate (120mM), and is an ideal natural laboratory for studying microbial sulfur cycling. Mono Lake is typically thermally stratified in summer while mixing completely in winter. However, large snowmelt inputs may induce salinity stratification that persists for up to five years, causing meromixis. During the California drought of 2014-16, the lake has mixed thoroughly each winter, but the abundant 2017 snowmelt may usher in a multi-year stratification. This natural experiment provides an opportunity to investigate the temporal relationship between microbial sulfur cycling and lake biogeochemistry. We analyzed water samples from five depths at two stations in May of 2017, before the onset of meromixis. Water column sulfate isotope values were generally constant with depth, centering at a δ34SVCDT of 17.39 ± 0.06‰. Organic sulfur isotopes were consistently lighter than lake sulfate, with a δ34SVCDT of 15.59 ± 0.56‰. This significant offset between organic and inorganic sulfur contradicts the minimal isotope effect associated with sulfate assimilation. Sediment push core organic values were further depleted, ranging between δ34SVCDT of -8.94‰ and +0.23‰, implying rapid turnover of Mono Lake sulfur pools. Both lipid biomarkers and 16S rRNA gene amplicons identify Picocystis salinarum, a unicellular green alga, as the dominant member of the microbial community. However, bacterial biomarkers and 16S rRNA genes point to microbes capable of sulfur cycling. We found that dsrA increased with depth (R2 = 0.9008, p reducers and sulfide oxidizers after >1 year of stratification. We saw no evidence in May of 2017 of sulfate reducing bacteria across the oxycline. Additionally, no sulfide was detectable in lake bottom waters despite oxygen below 6.25 µM. Preliminary results suggest a dynamic interplay between sulfide oxidation, sulfate reduction, and the onset of lake stratification. Additional

Production of mono sugar from acid hydrolysis of seaweed | Jang ...

African Journals Online (AJOL)

... the process conditions for the saccharification of macroalgae (seaweed) into mono sugar using the following parameters such as: Amount of biomass, catalyst concentration, temperature and reaction time. The major component of Ulva pertusa (green seaweed), Laminaria japonica (brown seaweed) and Gelidium amansii ...

Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor

International Nuclear Information System (INIS)

Craig, Zelieann R.; Hannon, Patrick R.; Flaws, Jodi A.

2013-01-01

Mono-hydroxy methoxychlor (mono-OH MXC) is a metabolite of the pesticide, methoxychlor (MXC). Although MXC is known to decrease antral follicle numbers, and increase follicle death in rodents, not much is known about the ovarian effects of mono-OH MXC. Previous studies indicate that mono-OH MXC inhibits mouse antral follicle growth, increases follicle death, and inhibits steroidogenesis in vitro. Further, previous studies indicate that CYP11A1 expression and production of progesterone (P 4 ) may be the early targets of mono-OH MXC in the steroidogenic pathway. Thus, this study tested whether supplementing pregnenolone, the precursor of progesterone and the substrate for HSD3B, would prevent decreased steroidogenesis, inhibited follicle growth, and increased follicle atresia in mono-OH MXC-treated follicles. Mouse antral follicles were exposed to vehicle (dimethylsulfoxide), mono-OH MXC (10 μg/mL), pregnenolone (1 μg/mL), or mono-OH MXC and pregnenolone together for 96 h. Levels of P 4 , androstenedione (A), testosterone (T), estrone (E 1 ), and 17β-estradiol (E 2 ) in media were determined, and follicles were processed for histological evaluation of atresia. Pregnenolone treatment alone stimulated production of all steroid hormones except E 2 . Mono-OH MXC-treated follicles had decreased sex steroids, but when given pregnenolone, produced levels of P 4 , A, T, and E 1 that were comparable to those in vehicle-treated follicles. Pregnenolone treatment did not prevent growth inhibition and increased atresia in mono-OH MXC-treated follicles. Collectively, these data support the idea that the most upstream effect of mono-OH MXC on steroidogenesis is by reducing the availability of pregnenolone, and that adding pregnenolone may not be sufficient to prevent inhibited follicle growth and survival. - Highlights: • Mono-OH MXC inhibited antral follicle steroidogenesis, growth, and survival. • Pregnenolone partially restored steroidogenesis in mono-OH MXC

Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor

Energy Technology Data Exchange (ETDEWEB)

Craig, Zelieann R., E-mail: zelieann@illinois.edu; Hannon, Patrick R., E-mail: phannon2@illinois.edu; Flaws, Jodi A., E-mail: jflaws@illinois.edu

2013-11-01

Mono-hydroxy methoxychlor (mono-OH MXC) is a metabolite of the pesticide, methoxychlor (MXC). Although MXC is known to decrease antral follicle numbers, and increase follicle death in rodents, not much is known about the ovarian effects of mono-OH MXC. Previous studies indicate that mono-OH MXC inhibits mouse antral follicle growth, increases follicle death, and inhibits steroidogenesis in vitro. Further, previous studies indicate that CYP11A1 expression and production of progesterone (P{sub 4}) may be the early targets of mono-OH MXC in the steroidogenic pathway. Thus, this study tested whether supplementing pregnenolone, the precursor of progesterone and the substrate for HSD3B, would prevent decreased steroidogenesis, inhibited follicle growth, and increased follicle atresia in mono-OH MXC-treated follicles. Mouse antral follicles were exposed to vehicle (dimethylsulfoxide), mono-OH MXC (10 μg/mL), pregnenolone (1 μg/mL), or mono-OH MXC and pregnenolone together for 96 h. Levels of P{sub 4}, androstenedione (A), testosterone (T), estrone (E{sub 1}), and 17β-estradiol (E{sub 2}) in media were determined, and follicles were processed for histological evaluation of atresia. Pregnenolone treatment alone stimulated production of all steroid hormones except E{sub 2}. Mono-OH MXC-treated follicles had decreased sex steroids, but when given pregnenolone, produced levels of P{sub 4}, A, T, and E{sub 1} that were comparable to those in vehicle-treated follicles. Pregnenolone treatment did not prevent growth inhibition and increased atresia in mono-OH MXC-treated follicles. Collectively, these data support the idea that the most upstream effect of mono-OH MXC on steroidogenesis is by reducing the availability of pregnenolone, and that adding pregnenolone may not be sufficient to prevent inhibited follicle growth and survival. - Highlights: • Mono-OH MXC inhibited antral follicle steroidogenesis, growth, and survival. • Pregnenolone partially restored steroidogenesis

The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2

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Paolo Swuec

2017-01-01

Full Text Available Activation of the main DNA interstrand crosslink repair pathway in higher eukaryotes requires mono-ubiquitination of FANCI and FANCD2 by FANCL, the E3 ligase subunit of the Fanconi anemia core complex. FANCI and FANCD2 form a stable complex; however, the molecular basis of their ubiquitination is ill defined. FANCD2 mono-ubiquitination by FANCL is stimulated by the presence of the FANCB and FAAP100 core complex components, through an unknown mechanism. How FANCI mono-ubiquitination is achieved remains unclear. Here, we use structural electron microscopy, combined with crosslink-coupled mass spectrometry, to find that FANCB, FANCL, and FAAP100 form a dimer of trimers, containing two FANCL molecules that are ideally poised to target both FANCI and FANCD2 for mono-ubiquitination. The FANCC-FANCE-FANCF subunits bridge between FANCB-FANCL-FAAP100 and the FANCI-FANCD2 substrate. A transient interaction with FANCC-FANCE-FANCF alters the FANCI-FANCD2 configuration, stabilizing the dimerization interface. Our data provide a model to explain how equivalent mono-ubiquitination of FANCI and FANCD2 occurs.

Heavy metals behaviour during mono-combustion and co-combustion of sewage sludge

Energy Technology Data Exchange (ETDEWEB)

Lopes, M. Helena; Abelha, Pedro; Olieveira, J.F. Santos; Gulyurtlu, Ibrahim; Cabrita, Isabel [INETI-DEECA, Lisboa (Portugal)

2005-03-01

This paper presents the study of the combustion of granular dry sewage sludge performed on a pilot fluidized bed system. The results of mono-combustion of sludge and co-combustion with coal were compared with those of coal combustion for ash partitioning, the formation of gaseous pollutants and heavy metals behaviour. It was found that the mineral matter of sludge was essentially retained as bottom ashes. The production of fines ashes was small during the mono-combustion due to the tendency of coal to produce fine ashes which also contained unburned char. The degree of heavy metal volatilization was found to be slightly higher during co-combustion than in mono-combustion; however, most of them were retained in ashes and their emissions were found to be below the regulated levels. Hg was completely volatilized; however, during combustion trials involving coal it was captured by cyclone ashes at temperatures below 300 deg C. During sludge mono-combustion the retention of Hg in cyclone ashes containing low LOI was not enough to decrease emissions below the regulated levels; hence, it is necessary to install dedicated flue gas treatment for Hg removal. The leachability and ecotoxicity of sludge and ashes was compared with the new regulatory limits for landfill disposal in the EU. It was found that the release of organic matter and heavy metals found in the sludge was low from granular bed ashes; hence, except for sulphate release, bed ashes were converted into inert and non-ecotoxic materials. Ashes from test with limestone and cyclone ashes seemed to be more problematic because of pH effects and contamination with steel corrosion products. The recovery and reutilization of sludge bed ashes could, therefore, be possible, as long as the release of sulphate do not interfere with the process.

Rotavirus infection in children: mono-and combines forms, especially clinics and course

Directory of Open Access Journals (Sweden)

N. B. Denisyuk

2012-01-01

Full Text Available Analyzed 74 case histories of children under one year with rotavirus infection. The most commonly detected rotavirus gastroenteritis in the form of mono-and combined forms. Mono-infection in 78.3% of cases occurred in the moderate form with a leading syndrome in the form of gastroenteritis, severe dehydration proceeded with symptoms of varying severity. Mixed variants in 98.7% of cases are in the unfavorable premorbid background, in 42.8% of children were registered in the severe forms, and children younger than 6 months were erased within. The diagnosis of intestinal infection was confirmed by PCR, bacteriological and immunological methods.

Increased CD56(bright) NK cells in HIV-HCV co-infection and HCV mono-infection are associated with distinctive alterations of their phenotype.

Science.gov (United States)

Bhardwaj, Suvercha; Ahmad, Fareed; Wedemeyer, Heiner; Cornberg, Marcus; Schulze Zur Wiesch, Julian; van Lunzen, Jan; Sarin, Shiv K; Schmidt, Reinhold E; Meyer-Olson, Dirk

2016-04-18

HIV-HCV co-infection is associated with accelerated progression to hepatic fibrosis, cirrhosis and hepatocellular carcinoma than HCV mono-infection. The contribution of innate immunity during HIV-HCV co-infection has been a relatively under-investigated area. Natural killer (NK) cells are pivotal sentinels of innate immunity against viruses and tumour cells. In this study we evaluated the effect of HIV-HCV co-infection on peripheral blood NK cell subsets with emphasis on the phenotype of CD56(bright) NK cells. Sixty patients were included in the study; HIV mono-infected (n = 12), HCV mono-infected (n = 15), HCV-HIV co-infected (n = 21) and healthy controls (n = 16). PBMCs were isolated and immunophenotyping of NK cells was performed by flowcytometry. We observed an expansion of CD56(bright) NK cell subset in HIV-HCV co-infection as compared to healthy controls and HIV mono-infected group. All the infected groups had an upregulated expression of the activating receptor NKG2D on CD56(bright) NK cells in comparison to healthy controls while not differing amongst themselves. The expression of NKp46 in HIV-HCV co-infected group was significantly upregulated as compared to both HIV as well as HCV mono-infections while NKp30 expression in the HIV-HCV co-infected group significantly differed as compared to HIV mono-infection. The CD56(bright) NK cell subset was activated in HIV-HCV co-infection as assessed by the expression of CD69 as compared to healthy controls but was significantly downregulated in comparison to HIV mono-infection. CD95 expression on CD56(bright) NK cells followed the same pattern where there was an increased expression of CD95 in HIV mono-infection and HIV-HCV co-infection as compared to healthy controls. In contrast to CD69 expression, CD95 expression in HCV mono-infection was decreased when compared to HIV mono-infection and HIV-HCV co-infection. Finally, expression of CXCR3 on CD56(bright) NK cells was increased in HIV-HCV co-infection in comparison

Dust Generation Resulting from Desiccation of Playa Systems: Studies on Mono and Owens Lakes, California

Science.gov (United States)

Gill, Thomas Edward

1995-01-01

Playas, evaporites, and aeolian sediments frequently are linked components within the Earth system. Anthropogenic water diversions from terminal lakes form playas that release fugitive dust. These actions, documented worldwide, simulate aeolian processes activated during palaeoclimatic pluvial/interpluvial transitions, and have significant environmental impacts. Pluvial lakes Russell and Owens in North America's Great Basin preceded historic Mono and Owens Lakes, now desiccated by water diversions into dust-generating, evaporite -encrusted playas. Geochemical and hydrologic cycles acting on the Owens (Dry) Lake playa form three distinct crust types each year. Although initial dust production results from deflation of surface efflorescences after the playa dries, most aerosols are created by saltation abrasion of salt/silt/clay crusts at crust/ sand sheet contacts. The warm-season, clastic "cemented" crust is slowest to degrade into dust. If the playa surface is stabilized by an unbroken, non-efflorescent crust, dust formation is discouraged. When Mono Lake's surFace elevation does not exceed 1951 meters (6400 feet), similar processes will also generate dust from its saline lower playa. Six factors--related to wind, topography, groundwater, and sediments--control dust formation at both playas. These factors were combined into a statistical model relating suspended dust concentrations to playa/lake morphometry. The model shows the extent and severity of Mono Lake dust storms expands significantly below the surface level 6376 feet (1943.5 meters). X-ray diffraction analysis of Mono Basin soils, playa sediments, and aerosols demonstrates geochemical cycling of materials through land, air and water during Mono Lake's 1982 low stand. Soils and clastic playa sediments contain silicate minerals and tephra. Saline groundwater deposited calcite, halite, thenardite, gaylussite, burkeite and glauberite onto the lower playa. Aerosols contained silicate minerals (especially

Assessment of genetic diversity and variation of acer mono max seedlings after spaceflight

International Nuclear Information System (INIS)

Long, C.; Li, Y.; Zhang, Y.; Yang, M.

2015-01-01

Genetic diversity and variation of Acer Mono Maxim seedlings sampled from space-mutated (sm) populations were compared to seedlings from parallel control (ck) ones using molecular markers. RAMP analysis showed that the percentage of polymorphic band, Shannon diversity index and Nei gene diversity index of the space-mutated populations were higher than those of the control ones, which indicated that genetic variation increased after spaceflight in populations of Acer Mono Maxim. By using un-weighted pair group method with arithmetic mean (UPGMA) method, three space-mutated repeats (populations) were clustered together, and control groups clustered separately, which further indicated that there was difference between the space-mutated ones and the control ones, which may be caused by space mutation. Further analysis of genomic inconsistency between the root and leaf samples from the same tree showed that a total variation rate of 6.3% and 1.7% were obtained in ten space-mutated individuals by using RAMP and SSR markers, respectively, however, the variation rate was zero in control ones. It provided that space mutation may be caused the individual variation of Acer Mono Maxim. (author)

MonoMax Suture: A New Long-Term Absorbable Monofilament Suture Made from Poly-4-Hydroxybutyrate

Directory of Open Access Journals (Sweden)

Erich K. Odermatt

2012-01-01

Full Text Available A long-term absorbable monofilament suture was developed using poly-4-hydroxybutyrate (P4HB made from a biosynthetically produced homopolymer of the natural metabolite 4-hydroxybutyrate. The suture, called MonoMax, has prolonged strength retention. At 12 weeks, a size 3-0 MonoMax suture retains approximately 50% of its initial tensile strength in vivo and is substantially degraded in one year with minimal tissue reaction. In contrast, PDS II monofilament suture (Ethicon, Inc., Somerville, NJ has no residual strength in vivo after 12 weeks. In vivo, the MonoMax suture is hydrolyzed primarily by bulk hydrolysis, and is then degraded via the Krebs cycle. MonoMax is substantially more compliant than other monofilament sutures, and incorporates an element of elasticity. Its tensile modulus of 0.48 GPa is approximately one-third of the value of the PDS II fiber providing an exceptionally flexible and pliable fiber with excellent knot strength and security. These features are further enhanced by the fiber's elasticity, which also improves knot security and may help prevent wound dehiscence. Because of its performance advantages, this suture may find clinical utility in applications where prolonged strength retention, and greater flexibility are required, particularly in procedures like abdominal wall closure where wound dehiscence is still a significant post-surgical complication.

Water miscible mono alcohols' effect on the proteolytic performance of Bacillus clausii serine alkaline protease.

Science.gov (United States)

Duman, Yonca Avci; Kazan, Dilek; Denizci, Aziz Akin; Erarslan, Altan

2014-01-01

In this study, our investigations showed that the increasing concentrations of all examined mono alcohols caused a decrease in the Vm, kcat and kcat/Km values of Bacillus clausii GMBE 42 serine alkaline protease for casein hydrolysis. However, the Km value of the enzyme remained almost the same, which was an indicator of non-competitive inhibition. Whereas inhibition by methanol was partial non-competitive, inhibition by the rest of the alcohols tested was simple non-competitive. The inhibition constants (KI) were in the range of 1.32-3.10 M, and the order of the inhibitory effect was 1-propanol>2-propanol>methanol>ethanol. The ΔG(≠) and ΔG(≠)E-T values of the enzyme increased at increasing concentrations of all alcohols examined, but the ΔG(≠)ES value of the enzyme remained almost the same. The constant Km and ΔG(≠)ES values in the presence and absence of mono alcohols indicated the existence of different binding sites for mono alcohols and casein on enzyme the molecule. The kcat of the enzyme decreased linearly by increasing log P and decreasing dielectric constant (D) values, but the ΔG(≠) and ΔG(≠)E-T values of the enzyme increased by increasing log P and decreasing D values of the reaction medium containing mono alcohols.

Anaerobic mono-digestion of lucerne, grass and forbs – Influence of species and cutting frequency

DEFF Research Database (Denmark)

Wahid, Radziah; Feng, Lu; Cong, Wenfeng

2018-01-01

but it was not possible to ascertain whether this was due to organic overload alone or if high ammonia levels during Lu-4 digestion were contributing to the reduced performance. It was found that four cuts per year was suitable for a lab-scale mono-digestion system as the substrate was less fibrous and has lower dry......In the present study, biogas potentials of multispecies swards including grass, lucerne, caraway, ribwort plantain and chicory from two- and four-cut regimes (Mix-2 and Mix-4) for mono-digestion applying batch and continuous modes under lab-scale conditions were investigated. The gas yields...... confirmed with continuous experiments, during which the reactor digesting Mix-4 was stable throughout the experiment with low ammonia and volatile fatty acid (VFA) concentration. Meanwhile, mono-digestion of Lu-4 led to elevated VFA levels, even at a comparatively low organic loading rate of 1.76 g L−1 d−1...

Retrograde axoplasmic flow of serotonin in central mono-aminergic neurons

International Nuclear Information System (INIS)

Leger, Lucienne; Pujol, J.-F.; Bobillier, Pierre; Jouvet, Michel

1977-01-01

Following an injection of 3 H-5 HT in the neostriatum of the Rat, the tracer is transported by axoplasmic retrograde flow to the cell groups containing mono-aminergic neurons which are known or thought to have afferences to this structure: substantia nigra, dopaminergic group A8 and n. raphe dorsalis [fr

Strenuous running exacerbates knee cartilage erosion induced by low amount of mono-iodoacetate in rats

OpenAIRE

Saito, Ryusuke; Muneta, Takeshi; Ozeki, Nobutake; Nakagawa, Yusuke; Udo, Mio; Yanagisawa, Katsuaki; Tsuji, Kunikazu; Tomita, Makoto; Koga, Hideyuki; Sekiya, Ichiro

2017-01-01

Background It is still debated whether strenuous running in the inflammatory phase produces beneficial or harmful effect in rat knees. We examined (1) the dropout rate of rats during a 30-km running protocol, (2) influences of strenuous running and/or low amounts of mono-iodoacetate injection on cartilage, and (3) the effect of strenuous running on synovitis. Methods Rats were forced to run 30?km over 6?weeks and the dropout rate was examined. One week after 0.1?mg mono-iodoacetate was inject...

Photo-modulation of the spin Hall conductivity of mono-layer transition metal dichalcogenides

Energy Technology Data Exchange (ETDEWEB)

Sengupta, Parijat; Bellotti, Enrico [Department of Electrical and Computer Engineering, Boston University, Boston, MA 02215 (United States)

2016-05-23

We report on a possible optical tuning of the spin Hall conductivity in mono-layer transition metal dichalcogenides. Light beams of frequencies much higher than the energy scale of the system (the off-resonant condition) do not excite electrons but rearrange the band structure. The rearrangement is quantitatively established using the Floquet formalism. For such a system of mono-layer transition metal dichalcogenides, the spin Hall conductivity (calculated with the Kubo expression in presence of disorder) exhibits a drop at higher frequencies and lower intensities. Finally, we compare the spin Hall conductivity of the higher spin-orbit coupled WSe{sub 2} to MoS{sub 2}; the spin Hall conductivity of WSe{sub 2} was found to be larger.

[Detection of fps tumor antigen with mono-specific anti-fps serum in tumors induced by acute transforming ALV].

Science.gov (United States)

Wang, Yixin; Chen, Hao; Zhao, Peng; Li, Jianliang; Cui, Zhizhong

2013-03-04

To prepare anti-fps mono-specific serum, and detect the fps antigen in tumors induced by acute transforming avian leukosis/sarcoma virus containing v-fps oncogene. Two part of v-fps gene was amplified by RT-PCR using the Fu-J viral RNA as the template. Mono-specific serum was prepared by immuning Kunming white mouse with both two recombinant infusion proteins expressed by the prokaryotic expression system. Indirect immunofluorescent assay was used to detect fps antigen in tumor tissue suspension cells and CEF infected by sarcoma supernatant. Immunohistochemical method was used to detect fps antigen in tumor tissue. The mouse mono-specific serum was specific as it had no cross reaction with classical ALV-J strains. The result reveals that the tumor tissue suspension cells, the CEF infected by sarcoma supernatant, and the slice immunohistochemistry of the sarcoma showed positive results. The anti-fps mono-specific serum was prepared, and the detection method was established, which laid the foundation for the study of viral biological characteristics and mechanism of tumourgenesis of acute transforming avian leukosis/sarcoma virus containing v-fps oncogene.

Influência da mono-hidrogenação da fração C5 na síntese do TAME usando Amberlyst 15 como catalisador Influence of mono-hydrogenation of C5 cut on the synthesis of TAME using Amberlyst 15

Directory of Open Access Journals (Sweden)

Gilberto da Cunha Gonçalves

2001-05-01

Full Text Available No presente trabalho, foi estudada a síntese do TAME, em fase líquida, a partir de uma fração C5 e metanol, utilizando Amberlyst 15 como catalisador. A fração C5 utilizada possui uma diolefina, que tem uma alta tendência à formação de gomas e um alto teor de mono-olefinas. Deste modo, o objetivo deste trabalho foi avaliar o efeito da mono-hidrogenação da fração C5 na síntese do TAME. A hidrogenação foi feita a 80oC e 10 kgf/cm2 de H2, usando um catalisador 0,3% Pt/Al2O3. A diolefina foi totalmente hidrogenada e o teor de mono-olefinas significativamente reduzido sem um decréscimo apreciável no teor de isoamilenos reativos. A eterificação foi feita em um reator tipo batelada de 250 mL, com agitação magnética. A temperatura foi variada na faixa de 50 a 90oC, com uma pressão de 10 kgf/cm2 e razão molar isoamileno/metanol de aproximadamente um. Os produtos de reação foram analisados por cromatografia gasosa. A conversão total observada foi aproximadamente a mesma para o os cortes original e mono-hidrogenado. Entretanto, os produtos obtidos utilizando a fração C5 original apresentaram cheiro forte e coloração, mesmos para os testes a temperaturas mais baixas, que são características da formação de gomas. Por outro lado, quando a fração mono-hidrogenada foi usada na eterificação, o cheiro forte e coloração não foram observados. Portanto, a mono-hidrogenação da fração C5 contendo os isoamilenos reativos é necessária para que o TAME produzido na reação de eterificação possa ser adicionado à gasolinaTAME was synthesized in liquid phase from refinery C5 cut and methanol using Amberlyst 15 as catalyst. The C5 stream contains mainly mono-olefins and, in a less amount, a diolefin, which have a high gum formation tendency. The main purpose of this research was to evaluate the effect of mono-hydrogenation of C5 cut on TAME synthesis. The hydrogenation step was carried out at 80 oC and 10 kgf/cm2 of H2

Experimental damping assessment of a full scale offshore mono bucket foundation

DEFF Research Database (Denmark)

Gres, Szymon; Fejerskov, Morten; Ibsen, Lars Bo

2016-01-01

This paper quantifies the system damping of a offshore meteorological mast supported by a Mono Bucket foundation based on a long-term experimental campaign. The structure is located at Dogger Bank west, North Sea, and equipped with a measurement system monitoring acceleration, strain, inclination...

In vitro quantification of the performance of model-based mono-planar and bi-planar fluoroscopy for 3D joint kinematics estimation.

Science.gov (United States)

Tersi, Luca; Barré, Arnaud; Fantozzi, Silvia; Stagni, Rita

2013-03-01

Model-based mono-planar and bi-planar 3D fluoroscopy methods can quantify intact joints kinematics with performance/cost trade-off. The aim of this study was to compare the performances of mono- and bi-planar setups to a marker-based gold-standard, during dynamic phantom knee acquisitions. Absolute pose errors for in-plane parameters were lower than 0.6 mm or 0.6° for both mono- and bi-planar setups. Mono-planar setups resulted critical in quantifying the out-of-plane translation (error bi-planar in quantifying the rotation along bone longitudinal axis (error bi-planar (error comparable to bi-planar, but with halved computational costs, halved segmentation time and halved ionizing radiation dose. Bi-planar analysis better compensated for the out-of-plane uncertainty that is differently propagated to relative kinematics depending on the setup. To take its full benefits, the motion task to be investigated should be designed to maintain the joint inside the visible volume introducing constraints with respect to mono-planar analysis.

Microbial ecology of soda lakes: investigating sulfur and nitrogen cycling at Mono Lake, CA, USA

Science.gov (United States)

Fairbanks, D.; Phillips, A. A.; Wells, M.; Bao, R.; Fullerton, K. M.; Stamps, B. W.; Speth, D. R.; Johnson, H.; Sessions, A. L.

2017-12-01

Soda lakes represent unique ecosystems characterized by extremes of pH, salinity and distinct geochemical cycling. Despite these extreme conditions, soda lakes are important repositories of biological adaptation and have a highly functional microbial system. We investigated the biogeochemical cycling of sulfur and nitrogen compounds in Mono Lake, California, located east of the Sierra Nevada mountains. Mono lake is characterized by hyperalkaline, hypersaline and high sulfate concentrations and can enter prolonged periods of meromixis due to freshwater inflow. Typically, the microbial sulfur cycle is highly active in soda lakes with both oxidation and reduction of sulfur compounds. However, the biological sulfur cycle is connected to many other main elemental cycles such as carbon, nitrogen and metals. Here we investigated the interaction between sulfur and nitrogen cycling in Mono lake using a combination of molecular, isotopic, and geochemical observations to explore the links between microbial phylogenetic composition and functionality. Metagenomic and 16S rRNA gene amplicon sequencing were determined at two locations and five depths in May 2017. 16S rRNA gene amplicon sequencing analysis revealed organisms capable of both sulfur and nitrogen cycling. The relative abundance and distribution of functional genes (dsrA, soxAB, nifH, etc) were also determined. These genetic markers indicate the potential in situ relevance of specific carbon, nitrogen, and sulfur pathways in the water column prior to the transition to meromictic stratification. However, genes for sulfide oxidation, denitrification, and ammonification were present. Genome binning guided by the most abundant dsrA sequences, GC content, and abundance with depth identified a Thioalkalivibrio paradoxus bin containing genes capable of sulfur oxidation, denitrification, and nitrate reduction. The presence of a large number of sulfur and nitrogen cycling genes associated with Thioalkalivibrio paradoxus

Advanced virtual monochromatic reconstruction of dual-energy unenhanced brain computed tomography in children: comparison of image quality against standard mono-energetic images and conventional polychromatic computed tomography

Energy Technology Data Exchange (ETDEWEB)

Park, Juil [Seoul National University Children' s Hospital, Department of Radiology, Seoul (Korea, Republic of); Choi, Young Hun [Seoul National University Children' s Hospital, Department of Radiology, Seoul (Korea, Republic of); Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Cheon, Jung-Eun; Kim, Woo Sun; Kim, In-One [Seoul National University Children' s Hospital, Department of Radiology, Seoul (Korea, Republic of); Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Seoul National University Medical Research Center, Institute of Radiation Medicine, Seoul (Korea, Republic of); Pak, Seong Yong [Siemens Healthineers, Seoul (Korea, Republic of); Krauss, Bernhard [Siemens Healthineers, Forchheim (Germany)

2017-11-15

Advanced virtual monochromatic reconstruction from dual-energy brain CT has not been evaluated in children. To determine the most effective advanced virtual monochromatic imaging energy level for maximizing pediatric brain parenchymal image quality in dual-energy unenhanced brain CT and to compare this technique with conventional monochromatic reconstruction and polychromatic scanning. Using both conventional (Mono) and advanced monochromatic reconstruction (Mono+) techniques, we retrospectively reconstructed 13 virtual monochromatic imaging energy levels from 40 keV to 100 keV in 5-keV increments from dual-source, dual-energy unenhanced brain CT scans obtained in 23 children. We analyzed gray and white matter noise ratios, signal-to-noise ratios and contrast-to-noise ratio, and posterior fossa artifact. We chose the optimal mono-energetic levels and compared them with conventional CT. For Mono+maximum optima were observed at 60 keV, and minimum posterior fossa artifact at 70 keV. For Mono, optima were at 65-70 keV, with minimum posterior fossa artifact at 75 keV. Mono+ was superior to Mono and to polychromatic CT for image-quality measures. Subjective analysis rated Mono+superior to other image sets. Optimal virtual monochromatic imaging using Mono+ algorithm demonstrated better image quality for gray-white matter differentiation and reduction of the artifact in the posterior fossa. (orig.)

Some transition metal complexes derived from mono- and di-ethynyl perfluorobenzenes

NARCIS (Netherlands)

Armitt, D.J.; Bruce, M.I.; Gaudio, M.; Zaitseva, N.N.; Skelton, B.W.; White, A.H.; Le Guennic, B.; Halet, J.-F.; Fox, M.A.; Roberts, R.L.; Hartl, F.; Low, P.J.

2008-01-01

Transition metal alkynyl complexes containing perfluoroaryl groups have been prepared directly from trimethylsilyl-protected mono- and di-ethynyl perfluoroarenes by simple desilylation/metallation reaction sequences. Reactions between Me3SiC CC6F5 and RuCl(dppe)Cp'[Cp' = Cp, Cp*] in the presence of

Radiation degradation and hemolytic toxicity evaluation of mono azo reactive dyes

International Nuclear Information System (INIS)

Saeed, Q.U.; Bhatti, I.A.; Ashraf, A.

2017-01-01

Monoazo reactive dyes have been synthesized and subjected to degradation before their application. Advanced oxidation process has been recognized as a promising radiation technology for the remediation of hazardous organic compounds. Radiation induced degradation of two mono azo reactive dyes have been tried at different absorbed dose, 5 kGy,10 kGy and 15 kGy. Aqueous solutions of these dyes were treated with gamma radiation using Cs 137 radiation source at Nuclear Institute of Agriculture and Biology (NIAB) Faisalabad. Dyes were evaluated spectrophotometrically by UV-visible and fourier transform infra red (FT-IR) spectroscopic techniques before and after irradiation to analyse their percentage decolorization and degradation. Maximum percentage decolorization of 93% and 63% was achieved for mono azo dyes D1 and D2 at 15 kGy absorbed dose. Toxicity study of these dyes was also tested by haemolytic activity assay. Percentage haemolytic activity of untreated dyes was found within permissible limit showing non toxicity of dye solutions. (author)

Simulation of gas hydrogen diffusion through partially water saturated mono-modal materials

International Nuclear Information System (INIS)

Boher, C.; Lorente, S.; Frizon, F.; Bart, F.

2012-01-01

Concerning the disposal of nuclear wastes, it is important to design concrete envelopes with pore networks that allow the diffusion of hydrogen towards the outside. This work documents the relationship between geo-polymers, which are materials with a quasi mono-modal pore network, and their gaseous diffusivity capacities. Using a mono-modal material allows studying a specific pore size contribution to gaseous diffusion. The pore network is characterized by mercury porosimetry. These experimental results are used as data in a model named MOHYCAN. The modeling work consists of creating a virtual pore network. Then, water layers are deposited in this network to simulate variable water saturation levels. Finally hydrogen is transported through the virtual network using a combination of ordinary diffusion and Knudsen diffusion. MOHYCAN calculates the hydrogen diffusion coefficient for water saturation degree from 0% to 100%. The impacts of the pore network arrangement or the pore network discretization have been studied. The results are, for a quasi mono-modal material: -) the diffusion coefficient is not sensitive to different virtual pore network arrangement; -) the diffusion coefficient values have a sharp drop at specific water saturation (this is due to the water saturation of the main and unique pore family); -) a 2 pores family based model is sufficient to represent the pore network. Theses observations will not be valid if we consider a material with a large pore size distribution, like cementitious materials

PKD1 Mono-Allelic Knockout Is Sufficient to Trigger Renal Cystogenesis in a Mini-Pig Model

OpenAIRE

He, Jin; Li, Qiuyan; Fang, Suyun; Guo, Ying; Liu, Tongxin; Ye, Jianhua; Yu, Zhengquan; Zhang, Ran; Zhao, Yaofeng; Hu, Xiaoxiang; Bai, Xueyuan; Chen, Xiangmei; Li, Ning

2015-01-01

PKD1 and PKD2 mutations could lead to autosomal dominant polycystic kidney disease (ADPKD), which afflicts millions of people worldwide. Due to the marked differences in the lifespan, size, anatomy, and physiology from humans, rodent ADPKD models cannot fully mimic the disease. To obtain a large animal model that recapitulates the disease, we constructed a mini-pig model by mono-allelic knockout (KO) of PKD1 using zinc finger nuclease. The mono-allelic KO pigs had lower PKD1 expression than t...

Biochemical Properties of a New Cold-Active Mono- and Diacylglycerol Lipase from Marine Member Janibacter sp. Strain HTCC2649

Directory of Open Access Journals (Sweden)

Dongjuan Yuan

2014-06-01

Full Text Available Mono- and di-acylglycerol lipase has been applied to industrial usage in oil modification for its special substrate selectivity. Until now, the reported mono- and di-acylglycerol lipases from microorganism are limited, and there is no report on the mono- and di-acylglycerol lipase from bacteria. A predicted lipase (named MAJ1 from marine Janibacter sp. strain HTCC2649 was purified and biochemical characterized. MAJ1 was clustered in the family I.7 of esterase/lipase. The optimum activity of the purified MAJ1 occurred at pH 7.0 and 30 °C. The enzyme retained 50% of the optimum activity at 5 °C, indicating that MAJ1 is a cold-active lipase. The enzyme activity was stable in the presence of various metal ions, and inhibited in EDTA. MAJ1 was resistant to detergents. MAJ1 preferentially hydrolyzed mono- and di-acylglycerols, but did not show activity to triacylglycerols of camellia oil substrates. Further, MAJ1 is low homologous to that of the reported fungal diacylglycerol lipases, including Malassezia globosa lipase 1 (SMG1, Penicillium camembertii lipase U-150 (PCL, and Aspergillus oryzae lipase (AOL. Thus, we identified a novel cold-active bacterial lipase with a sn-1/3 preference towards mono- and di-acylglycerides for the first time. Moreover, it has the potential, in oil modification, for special substrate selectivity.

IRIS Toxicological Review of Ethylene Glycol Mono-Butyl ...

Science.gov (United States)

EPA released the draft report, Toxicological Review for Ethylene Glycol Mono-Butyl Ether , that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments. EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of EGBE that will appear on the Integrated Risk Information System (IRIS) database.

Measurement and prediction of dabigatran etexilate mesylate Form II solubility in mono-solvents and mixed solvents

International Nuclear Information System (INIS)

Xiao, Yan; Wang, Jingkang; Wang, Ting; Ouyang, Jinbo; Huang, Xin; Hao, Hongxun; Bao, Ying; Fang, Wen; Yin, Qiuxiang

2016-01-01

Highlights: • Solubility of DEM Form II in mono-solvents and binary solvent mixtures was measured. • Regressed UNIFAC model was used to predict the solubility in solvent mixtures. • The experimental solubility data were correlated by different models. - Abstract: UV spectrometer method was used to measure the solubility data of dabigatran etexilate mesylate (DEM) Form II in five mono-solvents (methanol, ethanol, ethane-1,2-diol, DMF, DMAC) and binary solvent mixtures of methanol and ethanol in the temperature range from 287.37 K to 323.39 K. The experimental solubility data in mono-solvents were correlated with modified Apelblat equation, van’t Hoff equation and λh equation. GSM model and Modified Jouyban-Acree model were employed to correlate the solubility data in mixed solvent systems. And Regressed UNIFAC model was used to predict the solubility of DEM Form II in the binary solvent mixtures. Results showed that the predicted data were consistent with the experimental data.

Biosynthesis and Degradation of Mono-, Oligo-, and Polysaccharides: Introduction

Science.gov (United States)

Wilson, Iain B. H.

Glycomolecules, whether they be mono-, oligo-, or polysaccharides or simple glycosides, are—as any biological molecules—the products of biosynthetic processes; on the other hand, at the end of their lifespan, they are also subject to degradation. The beginning point, biochemically, is the fixation of carbon by photosynthesis; subsequent metabolism in plants and other organisms results in the generation of the various monosaccharides. These must be activated—typically as nucleotide sugars or lipid-phosphosugars—before transfer by glycosyltransferases can take place in order to produce the wide variety of oligo- and polysaccharides seen in Nature; complicated remodelling processes may take place—depending on the pathway—which result in partial trimming of a precursor by glycosidases prior to the addition of further monosaccharide units. Upon completion of the 'life' of a glycoconjugate, glycosidases will degrade the macromolecule finally into monosaccharide units which can be metabolized or salvaged for incorporation into new glycan chains. In modern glycoscience, a wide variety of methods—genetic, biochemical, analytical—are being employed in order to understand these various pathways and to place them within their biological and medical context. In this chapter, these processes and relevant concepts and methods are introduced, prior to elaboration in the subsequent more specialized chapters on biosynthesis and degradation of mono-, oligo-, and polysaccharides.

[Improvement of symptoms in mild hyperthyroidism with an extract of Lycopus europaeus (Thyreogutt® mono)].

Science.gov (United States)

Eiling, Rudolf; Wieland, Veronika; Niestroj, Michael

2013-02-01

Extracts of Lycopus europaeus are used clinically for the control of vegetative and irritative symptoms in mild hyperthyroidism. This study assessed the effects and safety of an extract of Lycopus europaeus (Thyreogutt® mono tablets or drops) in a general practice setting. The study was conducted as an open post-marketing surveillance study consisting of three cohorts, i.e. a prolective assessment in patients receiving Thyreogutt® mono for 4 weeks, a retrolective documentation of data from patients who had received at least one course (4 weeks) of Thyreogutt® mono therapy during the previous 2 years, and a control cohort receiving no drug treatment. Assessments comprised symptoms of mild hyperthyroidism, laboratory tests of thyroid function and adverse events surveillance. Response was defined as normal thyroid hormone values at the end of therapy or a reduction of at least 20% in the number of symptoms after treatment. Responder rates were calculated. Four hundred and three patients with mild symptomatic hyperthyroidism were observed. The prolective assessment included 146 patients, the retrolective assessment 171 patients, and the control cohort 86 untreated patients. The responder rate was 72.6% in the prolective assessment and 96.5% in the retrolective assessment whereas the responder rate in the untreated control cohort amounted to 41.2%. No adverse events were reported. The extract of Lycopus europaeus was well tolerated and associated with a statistically significant and clinically relevant improvement of the symptoms in mild hyperthyroidism. The improvement was markedly better in both Thyreogutt® mono cohorts than in the control cohort.

Immune biomarker differences and changes comparing HCV mono-infected, HIV/HCV co-infected, and HCV spontaneously cleared patients.

Directory of Open Access Journals (Sweden)

Lauren E Kushner

Full Text Available Immune biomarkers are implicated in HCV treatment response, fibrosis, and accelerated pathogenesis of comorbidities, though only D-dimer and C-reactive protein have been consistently studied. Few studies have evaluated HIV/HCV co-infection, and little longitudinal data exists describing a broader antiviral cytokine response.Fifty immune biomarkers were analyzed at baseline (BL and HCV end of treatment follow-up(FU time point using the Luminex 50-plex assay in plasma samples from 15 HCV-cleared, 24 HCV mono- and 49 HIV/HCV co-infected patients receiving antiretroviral treatment, who either did or did not receive pegylated-interferon/ribavirin HCV treatment. Biomarker levels were compared among spontaneous clearance patients, mono- and co-infected, untreated and HCV-treated, and sustained virologic responders (SVR and non-responders (NR at BL and FU using nonparametric analyses. A Bonferroni correction, adjusting for tests of 50 biomarkers, was used to reduce Type I error.Compared to HCV patients at BL, HIV/HCV patients had 22 significantly higher and 4 significantly lower biomarker levels, following correction for multiple testing. There were no significantly different BL levels when comparing SVR and NR in mono- or co-infected patients; however, FU levels changed considerably in co-infected patients, with seven becoming significantly higher and eight becoming significantly lower in SVR patients. Longitudinally between BL and FU, 13 markers significantly changed in co-infected SVR patients, while none significantly changed in co-infected NR patients. There were also no significant changes in longitudinal analyses of mono-infected patients achieving SVR or mono-infected and co-infected groups deferring treatment.Clear differences exist in pattern and quantity of plasma immune biomarkers among HCV mono-infected, HIV/HCV co-infected, and HCV-cleared patients; and with SVR in co-infected patients treated for HCV. Though >90% of patients were male and

Pulsed electromagnetic field affects intrinsic and endoplasmatic reticulum apoptosis induction pathways in MonoMac6 cell line culture.

Science.gov (United States)

Kaszuba-Zwoinska, J; Chorobik, P; Juszczak, K; Zaraska, W; Thor, P J

2012-10-01

Current studies were aimed to elucidate influence of pulsed electromagnetic field stimulation on cell viability and apoptosis induction pathways. For the experimental model we have chosen monocytic cell line MonoMac6 and several apoptosis inducers with different mechanism of death induction like puromycin, colchicine, cyclophosphamide, minocycline and hydrogen peroxide. MonoMac6 cell line was grown at density 1x10(5) cells/well in 96-well culture plates. To induce cell death cell cultures were treated with different apoptosis inducers like puromycin, colchicine, cyclophosphamide, minocycline, hydrogen peroxide and at the same time with pulsed electromagnetic field 50 Hz, 45±5 mT (PEMF) for 4 hour per each stimulation, three times, in 24 hours intervals. Afterwards, cells were harvested for flow cytometry analysis of cell viability measured by annexin V-APC labeled and propidium iodide staining. Expression of apoptosis related genes was evaluated by semi quantitative reverse transcription (RT)-PCR assay. NuPAGE Novex Western blot analysis was carried out for apoptosis inducing factor (AIF) abundance in cytosolic and nuclear extracts of MonoMac6 cells. Puromycin, colchicine and minocycline activated cells and simultaneously treated with PEMF have shown out diminished percentage of annexinV positive (AnV+) cells comparing to controls without PEMF stimulation. MonaMac6 cells puromycin/colchicyne and PEMF treated were to a higher extent double stained (AnV+,PI+), which means increased late apoptotic as well as necrotic (PI+) cells, than non-stimulated controls. On the other hand, minocycline activated cells prior to PEMF treatment showed diminished amount of apoptotic and necrotic (annexin V, annexin V and propidium iodide, propidium iodide positive staining) cells. The opposite effect of PEMF on the percentage of annexin V positively stained cells has been achieved after treatment of MonoMac6 culture with cyclophoshamide and hydrogen peroxide. PEMF enhanced early

A Tephra Database With an Intelligent Correlation System, Mono-Inyo Volcanic Chain, CA

Science.gov (United States)

Bursik, M.; Rogova, G.

2004-12-01

We are assembling a web-accessible, relational database of information on past eruptions of the Mono-Inyo volcanic chain, eastern California. The PostgreSQL database structure follows the North American Data Model and CordLink. The database allows us to extract the features diagnostic of particular pyroclastic layers, as well as lava domes and flows. The features include depth in the section, layer thickness and internal stratigraphy, mineral assemblage, major and trace element composition, tephra componentry and granulometry, and radiocarbon age. Our working hypotheses are that 1) the database will prove useful for unraveling the complex recent volcanic history of the Mono-Inyo chain 2) aided by the use of an intelligent correlation system integrated into the database system. The Mono-Inyo chain consists of domes, craters and flows that stretch for 50 km north-south, subparallel to the Sierran range front fault system. Almost all eruptions within the chain probably occurred less than 50,000 years ago. Because of the variety of magma and eruption types, and the migration of source regions in time and space, it is nontrivial to discern patterns of behaviour. We have explored the use of multiple artificial neural networks combined within the framework of the Dempster-Shafer theory of evidence to construct a hybrid information processing system as an aid in the correlation of Mono-Inyo pyroclastic layers. It is hoped that such a system could provide information useful to discerning eruptive patterns that would otherwise be difficult to sort and categorize. In a test case on tephra layers at known sites, the intelligent correlation system was able to categorize observations correctly 96% of the time. In a test case with layers at one unknown site, and using a pairwise comparison of the unknown site with the known sites, a one-to-one correlation between the unknown site and the known sites was found to sometimes be poor. Such a result could be used to aid a

IRIS Toxicological Review of Ethylene Glycol Mono Butyl Ether (Egbe) (Final Report)

Science.gov (United States)

EPA has finalized the Toxicological Review of Ethylene Glycol Mono Butyl Ether: in support of the Integrated Risk Information System (IRIS). Now final, this assessment may be used by EPA’s program and regional offices to inform decisions to protect human health.

Single-molecule magnetism in a single-ion triamidoamine uranium(V) terminal mono-oxo complex

Energy Technology Data Exchange (ETDEWEB)

King, David M.; McMaster, Jonathan; Lewis, William; Blake, Alexander J.; Liddle, Stephen T. [Nottingham Univ. (United Kingdom). School of Chemistry; Tuna, Floriana; McInnes, Eric J.L. [Manchester Univ. (United Kingdom). School of Chemistry

2013-04-26

Straightforward oxidation of a triamidoamine uranium(III) complex with trimethyl-N-oxide affords a uranium(V) terminal mono-oxo complex which is the first clear-cut example of a uranium(V) single-molecule magnet (SMM). This monometallic complex unambiguously shows that a strongly axially ligated and thus anisotropic ligand field can be used to overcome the limited magnetic anisotropy of uranium(V). [German] Die direkte Oxidation eines Triamidoamin-Uran(III)-Komplexes mit Trimethyl-N-oxid liefert einen terminalen Uran(V)-Mono(oxo)komplex, der das erste gesicherte Beispiel eines Uran(V)-Einzelmolekuelmagnets ist. Dieser monometallische Komplex zeigt eindeutig, dass ein starkes axiales und somit anisotropes Ligandenfeld die begrenzte magnetische Anisotropie von Uran(V) beseitigen kann.

Bi-articular Knee-Ankle-Foot Exoskeleton Produces Higher Metabolic Cost Reduction than Weight-Matched Mono-articular Exoskeleton

Science.gov (United States)

Malcolm, Philippe; Galle, Samuel; Derave, Wim; De Clercq, Dirk

2018-01-01

The bi-articular m. gastrocnemius and the mono-articular m. soleus have different and complementary functions during walking. Several groups are starting to use these biological functions as inspiration to design prostheses with bi-articular actuation components to replace the function of the m. gastrocnemius. Simulation studies indicate that a bi-articular configuration and spring that mimic the m. gastrocnemius could be beneficial for orthoses or exoskeletons. Our aim was to test the effect of a bi-articular and spring configuration that mimics the m. gastrocnemius and compare this to a no-spring and mono-articular configuration. We tested nine participants during walking with knee-ankle-foot exoskeletons with dorsally mounted pneumatic muscle actuators. In the bi-articular plus spring condition the pneumatic muscles were attached to the thigh segment with an elastic cord. In the bi-articular no-spring condition the pneumatic muscles were also attached to the thigh segment but with a non-elastic cord. In the mono-articular condition the pneumatic muscles were attached to the shank segment. We found the highest reduction in metabolic cost of 13% compared to walking with the exoskeleton powered-off in the bi-articular plus spring condition. Possible explanations for this could be that the exoskeleton delivered the highest total positive work in this condition at the ankle and the knee and provided more assistance during the isometric phase of the biological plantarflexors. As expected we found that the bi-articular conditions reduced m. gastrocnemius EMG more than the mono-articular condition but this difference was not significant. We did not find that the mono-articular condition reduces the m. soleus EMG more than the bi-articular conditions. Knowledge of specific effects of different exoskeleton configurations on metabolic cost and muscle activation could be useful for providing customized assistance for specific gait impairments. PMID:29551959

Bi-articular Knee-Ankle-Foot Exoskeleton Produces Higher Metabolic Cost Reduction than Weight-Matched Mono-articular Exoskeleton

Directory of Open Access Journals (Sweden)

Philippe Malcolm

2018-03-01

Full Text Available The bi-articular m. gastrocnemius and the mono-articular m. soleus have different and complementary functions during walking. Several groups are starting to use these biological functions as inspiration to design prostheses with bi-articular actuation components to replace the function of the m. gastrocnemius. Simulation studies indicate that a bi-articular configuration and spring that mimic the m. gastrocnemius could be beneficial for orthoses or exoskeletons. Our aim was to test the effect of a bi-articular and spring configuration that mimics the m. gastrocnemius and compare this to a no-spring and mono-articular configuration. We tested nine participants during walking with knee-ankle-foot exoskeletons with dorsally mounted pneumatic muscle actuators. In the bi-articular plus spring condition the pneumatic muscles were attached to the thigh segment with an elastic cord. In the bi-articular no-spring condition the pneumatic muscles were also attached to the thigh segment but with a non-elastic cord. In the mono-articular condition the pneumatic muscles were attached to the shank segment. We found the highest reduction in metabolic cost of 13% compared to walking with the exoskeleton powered-off in the bi-articular plus spring condition. Possible explanations for this could be that the exoskeleton delivered the highest total positive work in this condition at the ankle and the knee and provided more assistance during the isometric phase of the biological plantarflexors. As expected we found that the bi-articular conditions reduced m. gastrocnemius EMG more than the mono-articular condition but this difference was not significant. We did not find that the mono-articular condition reduces the m. soleus EMG more than the bi-articular conditions. Knowledge of specific effects of different exoskeleton configurations on metabolic cost and muscle activation could be useful for providing customized assistance for specific gait impairments.

Bi-articular Knee-Ankle-Foot Exoskeleton Produces Higher Metabolic Cost Reduction than Weight-Matched Mono-articular Exoskeleton.

Science.gov (United States)

Malcolm, Philippe; Galle, Samuel; Derave, Wim; De Clercq, Dirk

2018-01-01

The bi-articular m. gastrocnemius and the mono-articular m. soleus have different and complementary functions during walking. Several groups are starting to use these biological functions as inspiration to design prostheses with bi-articular actuation components to replace the function of the m. gastrocnemius. Simulation studies indicate that a bi-articular configuration and spring that mimic the m. gastrocnemius could be beneficial for orthoses or exoskeletons. Our aim was to test the effect of a bi-articular and spring configuration that mimics the m. gastrocnemius and compare this to a no-spring and mono-articular configuration. We tested nine participants during walking with knee-ankle-foot exoskeletons with dorsally mounted pneumatic muscle actuators. In the bi-articular plus spring condition the pneumatic muscles were attached to the thigh segment with an elastic cord. In the bi-articular no-spring condition the pneumatic muscles were also attached to the thigh segment but with a non-elastic cord. In the mono-articular condition the pneumatic muscles were attached to the shank segment. We found the highest reduction in metabolic cost of 13% compared to walking with the exoskeleton powered-off in the bi-articular plus spring condition . Possible explanations for this could be that the exoskeleton delivered the highest total positive work in this condition at the ankle and the knee and provided more assistance during the isometric phase of the biological plantarflexors. As expected we found that the bi-articular conditions reduced m. gastrocnemius EMG more than the mono-articular condition but this difference was not significant. We did not find that the mono-articular condition reduces the m. soleus EMG more than the bi-articular conditions . Knowledge of specific effects of different exoskeleton configurations on metabolic cost and muscle activation could be useful for providing customized assistance for specific gait impairments.

Perceived Audio Quality Analysis in Digital Audio Broadcasting Plus System Based on PEAQ

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K. Ulovec

2018-04-01

Full Text Available Broadcasters need to decide on bitrates of the services in the multiplex transmitted via Digital Audio Broadcasting Plus system. The bitrate should be set as low as possible for maximal number of services, but with high quality, not lower than in conventional analog systems. In this paper, the objective method Perceptual Evaluation of Audio Quality is used to analyze the perceived audio quality for appropriate codecs --- MP2 and AAC offering three profiles. The main aim is to determine dependencies on the type of signal --- music and speech, the number of channels --- stereo and mono, and the bitrate. Results indicate that only MP2 codec and AAC Low Complexity profile reach imperceptible quality loss. The MP2 codec needs higher bitrate than AAC Low Complexity profile for the same quality. For the both versions of AAC High-Efficiency profiles, the limit bitrates are determined above which less complex profiles outperform the more complex ones and higher bitrates above these limits are not worth using. It is shown that stereo music has worse quality than stereo speech generally, whereas for mono, the dependencies vary upon the codec/profile. Furthermore, numbers of services satisfying various quality criteria are presented.

Synergistic extraction of Am(III) using HTTA and bi-functional (DHDECMP) and mono-functional (TBP) donors

International Nuclear Information System (INIS)

Pai, S.A.; Lohithakshan, K.V.; Mithapara, P.D.; Aggarwal, S.K.

1999-01-01

The equilibrium constant (log Ks) for the organic phase synergistic reaction for Am(III)-HTTA system with bi-functional neutral donor di-hexyl di-ethyl carbamoylmethyl phosphonate (DHDECMP) was found to be about two orders of magnitude higher than that of the mono-functional neutral donor (TBP) with comparable basicity values. This log Ks value along with a large positive entropy change with DHDECMP compared to that with TBP confirms that the neutral donors like DHDECMP behave as bi-functional, in sharp contrast to its mono-functional behaviour in Pu(VI). (author)

Intra-articular osteoid osteoma as a differential diagnosis of diffuse mono-articular joint pain.

Science.gov (United States)

Rolvien, Tim; Zustin, Jozef; Mussawy, Haider; Schmidt, Tobias; Pogoda, Pia; Ueblacker, Peter

2016-11-04

The aim of this retrospective study was to investigate the frequency of intra-articular osteoid osteoma (iaOO) in a large study cohort and to demonstrate its clinical relevance as an important differential diagnosis of non-specific mono-articular joint pain. We searched the registry for bone tumours of the University Medical Centre Hamburg-Eppendorf for osteoid osteomas in the last 42 years. Herein, we present three selected iaOO which were detected in the three major weight-bearing joints. Computed tomography (CT) or magnetic resonance imaging (MRI) scans were performed for initial diagnosis. Out of a total of 367 osteoid osteomas, 19 (5.2 %) tumours were localized intra-articularly. In all three presented tumours, a history of severe mono-articular pain was reported; however, the mean time to correct diagnosis was delayed to 20.7 months. Clearly, the nidus seen in CT and MRI images in combination with inconsistent salicylate-responsive nocturnal pain led to the diagnosis of iaOO. Rarely, osteoid osteoma can occur in an intra-articular location. In cases of diffuse mono-articular pain, iaOO should be considered both in large and smaller joints to avoid delays in diagnosis and therapy of this benign bone tumour.

Structure of the Mina Deflection in Mono Lake, CA: Inferences from Paleoseismology

Science.gov (United States)

Sangani, Radhika Chandrakant

Walker Lane, a zone of transcurrent faulting along the Sierran range front, is dominated by NNW trending normal faults. Within the Walker Lane, the Mina Deflection is a region of structural anomaly, where a significant component of regional displacement and seismicity is transferred from NNW-trending faults to ENE-trending faults of the Excelsior-Coledale domain. Geographically, the western boundary of the Mina Deflection lies along the western margin of Mono Basin. This is kinematically implied by the distributed tensional and shear stress in the NNW- and ENE- trending faults of the region. Transfer of strain from the NNW-trending, right-lateral oblique slip faults to the ENE-trending, primarily left-lateral faults is poorly understood. The nature of this transfer is complicated by the presence of the young volcanics of Mono Lake at the stepover bend. I undertook detailed study of the sub-km scale geometry and kinematics of the stepover bend, and its relation to nearby recent magmatic fluid flow within the Mono Lake. Fault orientations, slip rates and ages of most recent events allow for understanding strain transfer between faulting and volcanism. The results suggest that strain is transferred from the outer arc to the inner arc of the stepover bend. Within the inner arc, the magmatism on Paoha Island seems to have arisen from a sill-like intrusion. Furthermore, strain transfer is accomplished through sets of faults and fissures that variously act as large-scale Reidel shears and tension gashes allowing the migration of magmatic fluids from depth.

Maillard reaction products of rice protein hydrolysates with mono-, oligo- and polysaccharides

Science.gov (United States)

Rice protein, a byproduct of rice syrup production, is abundant but, its lack of functionality prevents its wide use as a food ingredient. Maillard reaction products of (MRPs) hydrolysates from the limited hydrolysis of rice protein (LHRP) and various mono-, oligo- and polysaccharides were evaluat...

Scour properties of mono bucket foundation

DEFF Research Database (Denmark)

Stroescu, Ionut Emanuel; Frigaard, Peter Bak

2016-01-01

Field experience proved that the Mono Bucket Foundations (MBFs) have good response against scour development. Moreover, the ratio between large diameter (bucket lid) and the small diameter (shaft tower) is the driving parameter for the process of erosion/backfill, like scour protection diameter...... in the case of scour protected monopiles. However, the structural design to reduce the scour development for MBFs is still open to optimization. The influences of parameters that generate backfill and scour, the transfer load webs and the misalignment with seabed, have not been systematically studied until...... analysis compared with real surveys and existing studies showed good agreements. Scour protection based on collar solution shows high efficiency when scour protection should be required. The paper demonstrates good agreement between field measurements and small-scale studies. The unique value of the field...

SURVEY, MONO COUNTY, CALIFORNIA

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — Survey data includes spatial datasets and data tables necessary to digitally represent data collected in the survey phase of the study. (Source: FEMA Guidelines and...

21 CFR 582.4101 - Diacetyl tartaric acid esters of mono- and diglycerides of edible fats or oils, or edible fat...

Science.gov (United States)

2010-04-01

... diglycerides of edible fats or oils, or edible fat-forming fatty acids. 582.4101 Section 582.4101 Food and... Diacetyl tartaric acid esters of mono- and diglycerides of edible fats or oils, or edible fat-forming fatty acids. (a) Product. Diacetyl tartaric acid esters of mono- and diglycerides of edible fats or oils, or...

Synthesis and Anti-Proliferative Effects of Mono- and Bis-Purinomimetics Targeting Kinases

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Andrea Bistrović

2017-11-01

Full Text Available A series of mono-pyrrolo[2,3-d]pyrimidines 4a–4k, unsymmetrical bis-purine isosteres 5a–5e and symmetrical bis-pyrrolo[2,3-d]pyrimidines 6a and 6b connected via di(1,2,3-triazolylphenyl linker were synthesized by click chemistry. Whereas mono- 4g and bis-pseudopurine 5e showed selective inhibitory activities on cervical carcinoma (HeLa cells, bis-pyrrolo[2,3-d]pyrimidine 6b exhibited potent and selective anti-proliferative effect in the nanomolar range on pancreatic carcinoma (CFPAC-1 cells. Among these, compound 6b induced a significant reduction in the expression level of CDK9 (cyclin-dependent kinase 9/cyclin T1 in CFPAC-1 cells concomitant with attenuation of proliferative signaling mediated by c-Raf (rapidly accelerated fibrosarcoma and p38 MAP (mitogen-activated protein kinases. Our findings encourage further development of novel structurally related analog of 6b to obtain more selective anticancer agent for treating pancreatic cancer.

High pressure structural phase transition of neodymium mono pnictides

International Nuclear Information System (INIS)

Pagare, Gitanjali; Ojha, P.; Sanyal, S.P.; Aynyas, Mahendra

2007-01-01

We have investigated theoretically the high-pressure structural phase transition of two neodymium mono NdX (X=As, Sb) using an interionic potential theory with necessary modification to include the effect of Coulomb screening by the delocalized f electrons of Nd ion. These compounds exhibits first order crystallographic phase transition from their NaCl (B 1 ) phase to body centered tetragonal (BCT) at 27 GPa and 15.3 GPa respectively. We also calculated the Nd-Nd distance as a function of pressure. (author)

Screening for nonalcoholic steatohepatitis by using cytokeratin 18 and transient elastography in HIV mono-infection.

Directory of Open Access Journals (Sweden)

Amine Benmassaoud

Full Text Available HIV-infected individuals are at high risk of developing nonalcoholic steatohepatitis (NASH, a leading cause of end-stage liver disease in Western countries. Nonetheless, due to the invasiveness of liver biopsy, NASH remains poorly understood in HIV mono-infection. We aimed to characterize the prevalence and predictors of NASH in unselected HIV mono-infected patients by means of non-invasive diagnostic tools.HIV-infected adults without significant alcohol intake or co-infection with hepatitis B or C underwent a routine screening program employing transient elastography (TE with controlled attenuation parameter (CAP and the serum biomarker cytokeratin-18 (CK-18. NASH was diagnosed non-invasively as the coexistence of fatty liver (CAP ≥248 dB/m and CK-18 >246 U/L. Identified cases of NASH were offered a diagnostic liver biopsy. Predictors of NASH were determined by multivariate logistic regression analysis.202 consecutive HIV mono-infected patients were included. NASH was non-invasively diagnosed in 23 cases (11.4%. Among them, 17 underwent a liver biopsy, and histology confirmed NASH in all cases. The prevalence of NASH was higher in patients with hypertriglyceridemia (17.1%, insulin resistance defined by homeostasis model for assessment of insulin resistance (HOMA-IR (25%, those with detectable HIV viral load (42.9% and those with elevated ALT (53.6%. After adjustment, higher HOMA-IR (adjusted odds ratio [aOR] = 1.20, 95% CI 1.01-1.43; p = 0.03 and ALT (aOR = 2.39, 95% CI 1.50-3.79; p<0.001 were independent predictors of NASH.NASH, diagnosed by a non-invasive diagnostic approach employing CK-18 and TE with CAP, is common in unselected HIV mono-infected individuals, particularly in the presence of insulin resistance and elevated ALT.

Antagonistic Mono- and Bi-Articular Lower-Limb Muscle Activities’ Model Characterization at Different Speeds

Directory of Open Access Journals (Sweden)

Dzahir M.A.M

2017-01-01

Full Text Available Nowadays, medical rehabilitation system has become a requirement due to increment in national rehabilitation centres and medical hospitals. An assistive rehabilitation orthosis becomes essential and was used for rehabilitation therapy, condition monitoring, and physical strengthening. This study focused on the lower limb assistive rehabilitation orthosis development using pneumatic artificial muscle. To successfully control this orthosis system which consists of antagonistic mono- and biarticular muscle actuators, it is necessary to construct a reliable control algorithm. The suitable control scheme and strategy to manoeuvre this orthosis system similar to human musculoskeletal system have yet to be fully developed and established. Based on the review study, it is said that the co-contraction controls of anterior-posterior pneumatic muscles was able to improve the joint stiffness and stability of the orthosis as well as good manoeuvrability. Therefore, a characterization model of an antagonistic mono- and bi-articular muscles activities of human's lowerlimb during walking motion will be necessary. A healthy young male subject was used as test subject to obtain the sEMG muscle activities for antagonistic mono- and bi-articular muscles (i.e., Vastus Medialis-VM, Vastus Lateralis-VL, Rectus Femoris-RF, and Bicep Femoris-BF. The tests were carried out at different speeds of 2km/h, 3km/h, and 4km/h for one minute walking motion on a treadmill. Then, the patterns of the sEMG muscle activities were modelled and characterised using fifth order polynomial equation. Based on the results, it is shown that the anterior and posterior muscles were exhibited a muscle synergy in-between multiple anterior or posterior muscles and muscle co-contraction between anteriorposterior muscles in order to control the movements at the joints during walking motion. As conclusion, it is proven that the sEMG muscle activities of the antagonistic mono- and bi

An unusual mono-substituted Keggin anion-chain based 3D framework with 24-membered macrocycles as linker units

International Nuclear Information System (INIS)

Pang Haijun; Ma Huiyuan; Yu Yan; Yang Ming; Xun Ye; Liu Bo

2012-01-01

A new compound, [Cu I (H 2 O)(Hbpp) 2 ]⊂{[Cu I (bpp)] 2 [PW 11 Cu II O 39 ]} (1) (bpp=1,3-bis(4-pyridyl)propane), has been hydrothermally synthesized and structurally characterized by single crystal X-ray diffraction. In compound 1, the unusual –A–B–A–B– array mono-substituted Keggin anion-chains and 24-membered (Cubpp) 2 cation-macrocycles are linked together to form a (2, 4) connected 3D framework with channels of ca. 9.784×7.771 Å 2 along two directions, in which the [Cu(H 2 O)(Hbpp) 2 ] coordination fragments as guest components are trapped. The photocatalytic experiments of compound 1 were performed, which show a good catalytic activity of compound 1 for photodegradation of RhB. Furthermore, the IR, TGA and electrochemical properties of compound 1 were investigated. - Graphical abstract: An unusual example of mono-substituted Keggin anion-chain based hybrid compound that possesses a 3D structure has been synthesized, which offers a feasible route for synthesis of such compounds. Highlights: ► The first example of –A–B–A–B– array mono-substituted Keggin chain is observed. ► An unusual three dimensional structure based mono-substituted Keggin anion-chains. ► The photocatalysis and electrochemical properties of the title compound were studied.

Polyelectrolyte Properties in Mono and Multi-Valent Ionic Media: Brushes and Complex Coacervates

Science.gov (United States)

Farina, Robert M.

Materials composed of polyelectrolytes have unique and interesting physical properties resulting primarily from their charged monomer segments. Polyelectrolytes, which exist in many different biological and industrial forms, have also been shown to be highly responsive to external environmental changes. Here, two specific polyelectrolyte systems, brushes and complex coacervates, are discussed in regards to how their properties can be tailored by adjusting the surrounding ionic environment with mono and multi-valent ions. End-tethered polyelectrolyte brushes, which constitute an interesting and substantial portion of polyelectrolyte applications, are well known for their ability to provide excellent lubrication and low friction when coated onto surfaces (e.g. articular cartilage and medical devices), as well as for their ability to stabilize colloidal particles in solution (e.g. paint and cosmetic materials). These properties have been extensively studied with brushes in pure mono-valent ionic media. However, polyelectrolyte brush interactions with multi-valent ions in solution are much less understood, although highly relevant considering mono and multi-valent counterions are present in most applications. Even at very low concentrations of multi-valent ions in solution, dramatic polyelectrolyte brush physical property changes can occur, resulting in collapsed chains which also adhere to one another via multi-valent bridging. Here, the strong polyelectrolyte poly(sodium styrene sulfonate) was studied using the Surface Forces Apparatus (SFA) and electrochemistry in order to investigate brush height and intermolecular interactions between two brushes as a function of multi-valent counterion population inside a brush. Complex coacervates are formed when polyanions and polycations are mixed together in proper conditions of an aqueous solution. This mixing results in a phase separation of a polymer-rich, coacervate phase composed of a chain network held together via

Nuchal translucency measurements are highly correlated in both mono- and dichorionic twin pairs

DEFF Research Database (Denmark)

Wøjdemann, Karen R; Larsen, Severin Olesen; Shalmi, Anne-Cathrine

2006-01-01

OBJECTIVES: To establish the distribution of serological and ultrasound first-trimester Down syndrome markers in twins and identify correlations of significance for risk calculation. METHODS: Nuchal translucency (NT), PAPP-A and betahCG data were extracted from 181 twin pregnancies (31 mono- and ...

Radiocarbon constraints on fossil thinolite tufa formation in the Mono Basin, CA, USA

Science.gov (United States)

Leroy, S. L.; Zimmerman, S. R.; Hemming, S. R.; Stine, S.; Guilderson, T. P.

2009-12-01

Mono Lake is a terminal lake located at the western edge of the Great Basin, and is famous for its tufa towers. Thinolite, which is thought to be a CaCO3 pseudomorph of ikaite, is found around the Mono Basin in many fossil tufa towers, particularly at elevations above 2000 meters. The subaqueous parent mineral ikaite forms at low temperatures (34 kyr) to as young as 15.5 14C kyr BP. In general there is a consistent stratigraphic trend of ages within the mound, but the thinolite ages are anomalously young and one thinolite sample shows a large age reversal. The best estimate of the age of the precipitation of this tufa mound is given by the non-thinolite textures. More work is needed to determine the best sampling and sample preparation strategies in order to get a reliable age model for this mound.

Differences in Classification Between Mono- and Polytrauma and Low- and High-Energy Trauma Patients With an Ankle Fracture: A Retrospective Cohort Study

NARCIS (Netherlands)

Briet, Jan Paul; Houwert, Roderick Marijn; Smeeing, Diederik P. J.; Dijkgraaf, Marcel G. W.; Verleisdonk, Egbert Jan; Leenen, Luke P. H.; Hietbrink, Falco

2017-01-01

Although fracture type and treatment options for ankle fractures are well defined, the differences between mono- and polytrauma patients and low- and high-energy trauma have not been addressed. The aim of the present study was to compare the fracture type and trauma mechanism between mono- and

The MONOS memory transistor: application in a radiation-hard nonvolatile RAM

International Nuclear Information System (INIS)

Brown, W.D.

1985-01-01

The MONOS (metal-oxide-nitride-oxide-silicon) device is a prime candidate for use as the nonvolatile memory element in a radiation-hardened RAM (random-access memory). The endurance, retention and radiation properties of MONOS memory transistors have been studied as a function of post nitride deposition annealing. Following the nitride layer deposition, all devices were subjected to an 800 0 C oxidation step and some were then annealed at 900 0 C in nitrogen. The nitrogen anneal produces an increase in memory window size of approximately 40%. The memory window center of the annealed devices is shifted toward more positive voltages and is more stable with endurance cycling. Endurance cycling to 10 9 cycles produces a 20% increase in memory window size and a 60% increase in decay rate. For a radiation total dose of 10 6 rads (Si), the memory window size is essentially unchanged and the decay rate increases approximately 13%. A combination of 10 9 cycles and 10 6 rads (Si) reduces the decades of retention (in sec) from 6.3 to 4.3 for a +- 23-V 16-μsec write/erase pulse. (author)

Endotoxin testing of proteins for parenteral administration using the Mono Mac 6 assay

DEFF Research Database (Denmark)

Moesby, Lise; Hansen, E W; Christensen, J D

2000-01-01

Pharmaceutical products containing proteins cause problems in testing for endotoxin and pyrogens. Many proteins interfere with the LAL test and the proteins are immunogenic in rabbits. The monocytic cell line Mono Mac 6 is an alternative assay for detection of endotoxin and other pyrogens....

The nest predator assemblage for songbirds in Mono Lake basin riparian habitats

Science.gov (United States)

Quresh S. Latif; Sacha K. Heath; Grant Ballard

2012-01-01

Because nest predation strongly limits avian fitness, ornithologists identify nest predators to inform ecological research and conservation. During 2002–2008, we used both video-monitoring of natural nests and direct observations of predation to identify nest predators of open-cup nesting riparian songbirds along tributaries of Mono Lake, California. Video cameras at...

[Synthesis and biological activity of 2,3-secotriterpene acid mono- and diamides].

Science.gov (United States)

Tolmacheva, I A; Igosheva, E V; Vikharev, Iu B; Grishko, V V; Savinova, O V; Boreko, E I; Eremin, V F

2013-01-01

Four types of amide (C3; C28; C3-C28) conjugates based on 2,3-seco-18alphaH-oleanane and 2,3-secolupane mono- and dicarboxylic acids were synthesized. The range of diamide derivatives was supplemented with C3-C3' and C28-C28' dicondensed amides with two A-secotriterpene backbones educed by reacting monocarboxylic A-secoacids with biogenic amino acid lysine. Compounds with inhibitory action against herpes virus reproduction (EC50 8.7 and 4.1 McM) were found among the synthesized mono- and diamide derivatives containing an ethyl-beta-alaninate fragment. It has been ascertained that diamide with ethyl-beta-alaninate fragment combines anti-herpes virus properties and anti-HIV activity (EC50 5.1 McM). For active compounds, the maximum non-toxic concentration (MNTC)/EC50 ratios ranges from 9.7 to 40.8. The synthesized amide conjugates do not exhibit any marked cytotoxic effects against human tumor cell lines rabdomiosarcoma RD TE32, A549 lung carcinoma and melanoma MS.

Fabrication and Application of Mono-sized Spherical Micro Particles by Pulsated Orifice Ejection Method

Directory of Open Access Journals (Sweden)

DONG Wei

2018-02-01

Full Text Available A novel technology called pulsated orifice ejection method(POEM and used for preparing mono-sized and high-precision spherical micro particles was introduced in this article. The working principle of the technique was illustrated and it was in two modes:low-melting point diaphragm mode and high-melting point rod mode, depending on the different melting points of materials. The particles prepared by POEM have the advantages of mono-sized, uniform and controllable particle size, high sphericity, and consistent thermal history. By introducing the application of particles prepared by this method, showing the huge application prospects of this technology in electronic packaging, bioengineering, micro-fabrication, rapid solidification analysis of metal droplets, additive manufacturing and so on.With the development of POEM, this technology is predicted to have wider prospects due to its unique characteristics.

Calix[6]arene mono-diazonium salt synthesis and covalent immobilization onto glassy carbon electrodes

International Nuclear Information System (INIS)

Cannizzo, Caroline; Jasmin, Jean-Philippe; Vautrin-Ul, Christine; Chausse, Annie; Wagner, Mathieu; Doizi, Denis; Lamouroux, Christine

2014-01-01

This Letter describes the fast synthesis of a mono-aminated calix[6]arene. The immobilization of this macrocycle onto glassy carbon electrodes via diazonium salt chemistry and the electrochemical characterization of the grafted organic layer are also reported. (authors)

Mono-carboxylate conversion coatings for AZ31 Mg alloy protection

Energy Technology Data Exchange (ETDEWEB)

Frignani, A.; Grassi, V.; Zucchi, F.; Zanotto, F. [Corrosion Study Centre A. Dacco, University of Ferrara (Italy)

2011-11-15

Conversion coatings on a magnesium alloy were obtained by dipping AZ31 specimens in aqueous solutions of sodium salts of mono-carboxylic acids (stearic, palmitic, myristic, lauric, mono-carboxylate ion concentration from 1 to 5 mM, depending on the salt solubility) for 24 and 72 h at room temperature, or 24 h at 50 C. The influence exerted by the treatment time, bath temperature and alkyl chain length on the efficiency of these coatings was studied. The performances of the coatings were evaluated by potentiodynamic polarization curve recording after 1 h immersion in 0.05 M Na{sub 2}SO{sub 4} solution, while their temporal evolution was monitored by electrochemical impedance spectroscopy (EIS) spectra during 24 h. Further and long lasting tests were carried out also in 0.1 M NaCl solution. The efficiency of the coatings depended on the aliphatic chain length, and increased as the treatment time and the bath temperature were increased. The coating of lower homologue only hindered the cathodic process, while those of the higher homologues markedly inhibited the anodic process too. The best performances were displayed by 24 h-50 C stearic conversion coating, which maintained a very high efficiency for over 800 h immersion in 0.05 M sulphate solution. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Differences in Classification Between Mono- and Polytrauma and Low- and High-Energy Trauma Patients With an Ankle Fracture : A Retrospective Cohort Study

NARCIS (Netherlands)

Briet, Jan Paul; Houwert, Roderick Marijn; Smeeing, Diederik P J; Dijkgraaf, Marcel G. W.; Verleisdonk, Egbert Jan M M; Leenen, Luke P H; Hietbrink, Falco

2017-01-01

Although fracture type and treatment options for ankle fractures are well defined, the differences between mono- and polytrauma patients and low- and high-energy trauma have not been addressed. The aim of the present study was to compare the fracture type and trauma mechanism between mono- and

Characteristics of poly- and mono-crystalline BeO and SiO{sub 2} as thermal and cold neutron filters

Energy Technology Data Exchange (ETDEWEB)

Adib, M.; Habib, N. [Reactor Physics Department, NRC, Atomic Energy Authority, Cairo (Egypt); Bashter, I.I. [Physics Department, Faculty of Science, Zagazig University (Egypt); Morcos, H.N.; El-Mesiry, M.S. [Reactor Physics Department, NRC, Atomic Energy Authority, Cairo (Egypt); Mansy, M.S., E-mail: drmohamedmansy88@hotmail.com [Reactor Physics Department, NRC, Atomic Energy Authority, Cairo (Egypt)

2015-09-01

Highlights: • Neutron filtering features of BeO and SiO{sub 2} poly- and mono-crystals. • Calculations of the cold and thermal neutron cross sections and transmission with the code “HEXA-FILTERS”. • Optimal mosaic spread, thicknesses and cutting planes for BeO and SiO{sub 2} mono-crystals. - Abstract: A simple model along with a computer code “HEXA-FILTERS” is used to carry out the calculation of the total cross-sections of BeO and SiO{sub 2} having poly or mono-crystalline form as a function of neutron wavelength at room (R.T.) and liquid nitrogen (L.N.) temperatures. An overall agreement is indicated between the calculated neutron cross-sections and experimental data. Calculation shows that 25 cm thick of polycrystalline BeO cooled at liquid nitrogen temperature was found to be a good filter for neutron wavelengths longer than 0.46 nm. While, 50 cm of SiO{sub 2}, with much less transmission, for neutrons with wavelengths longer than 0.85 nm. It was also found that 10 cm of BeO and 15 cm SiO{sub 2} thick mono-crystals cut along their (0 0 2) plane, with 0.5° FWHM on mosaic spread and cooled at L.N., are a good thermal neutron filter, with high effect-to-noise ratio.

Manufacturing and testing of W/Cu mono-block small scale mock-up for EAST by HIP and HRP technologies

Energy Technology Data Exchange (ETDEWEB)

Li, Qiang [Institute of Plasma Physics, Chinese Academy of Sciences (ASIPP), Hefei, Anhui (China); Qin, Sigui [Advanced Technology and Materials Co., Ltd, Beijing (China); Wang, Wanjing; Qi, Pan [Institute of Plasma Physics, Chinese Academy of Sciences (ASIPP), Hefei, Anhui (China); Roccella, Selanna; Visca, Eliseo [Associazione EURATOM-ENEA sulla Fusione, Frascati (Italy); Liu, Guohui [Advanced Technology and Materials Co., Ltd, Beijing (China); Luo, Guang-Nan, E-mail: liqiang577@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences (ASIPP), Hefei, Anhui (China)

2013-10-15

ITER-like W/Cu mono-block plasma-facing components (PFCs) will be used in vertical target regions of the experimental advanced superconducting tokamak (EAST) divertor. The first W/Cu mono-block small scale mock-up with five W mono-blocks has been manufactured successfully by technological combination of hot isostatic pressing (HIP) and hot radial pressing (HRP). The joining of a W mono-block and a pure copper interlayer was achieved by means of HIP technology and the bonding strength was over 150 MPa. The good bonding between the pure copper interlayer and a CuCrZr cooling tube was obtained by means of HRP technology. In order to understand deeply the process of HRP, the stress distribution of the mock-up during HRP process was simulated using ANSYS code. Ultrasonic Nondestructive Testing (NDT) of the W/Cu and Cu/CuCrZr interfaces was performed, showing that excellent bonding of the W/Cu and Cu/CuCrZr interfaces. The thermal cycle fatigue testing of the mock-up has been carried out by means of an e-beam device in Southwest Institute of Physics, Chengdu (SWIP) and the mock-up withstood 1000 cycles of heat loads up to 8.4 MW/m{sup 2} with the cooling water of 2 m/s, 20 °C, 0.2 MPa.

Unique Intramolecular Electronic Communications in Mono-ferrocenylpyrimidine Derivatives: Correlation between Redox Properties and Structural Nature

International Nuclear Information System (INIS)

Xiang, Debo; Noel, Jerome; Shao, Huibo; Dupas, Georges; Merbouh, Nabyl; Yu, Hua-Zhong

2015-01-01

Highlights: • Unique intramolecular electronic communications (electron withdrawing and π-bond delocalization effects) exist in the mono-ferrocenylpyrimidine derivatives. • The redox potential shift correlates the pyrimidine ring torsion angle with the extent of electron delocalization. • The correlation between redox properties and structural nature in mono-ferrocenylpyrimidine derivatives is evident. - Abstract: The correlation between redox properties and structural nature in a complete set of mono-ferrocenylpyrimidine derivatives (2-ferrocenylpyrimidine, 2-FcPy; 4-ferrocenylpyrimidine, 4-FcPy; 5-ferrocenylpyrimidine, 5-FcPy) was evaluated by investigating the intramolecular electronic communications. Both conventional electrochemical measurements in organic solvents and thin-film voltammetric studies of these compounds were carried out. It was discovered that their formal potentials are significantly different from each other, and shift negatively in the order of 4-FcPy > 5-FcPy > 2-FcPy. This result suggests that the intramolecular electronic communication is dictated by the delocalization effect of the π-bonding systems in 2-FcPy, and that the electron-withdrawing effect of the nitrogen atoms in the pyrimidine ring plays the key role in 4-FcPy and 5-FcPy. The single crystal X-ray structure analyis and Density Functional Theory (DFT) calculation provided additional evidence (e.g., different torsion angles between the cyclopentadienyl and pyrimidine rings) to support the observed correlation between the redox properties and structural nature

IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (Egbe) (Interagency Science Discussion Draft)

Science.gov (United States)

EPA released the draft report, Toxicological Review for Ethylene Glycol Mono-Butyl Ether , that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from ot...

Designing real-time systems based on mono-master Profibus-DP networks

OpenAIRE

Monforte, Salvatore; Alves, Mário; Vasques, Francisco; Tovar, Eduardo

2000-01-01

Profibus networks are widely used as the communication infrastructure for supporting distributed computer-controlled applications. Most of the times, these applications impose strict real-time requirements. Profibus-DP has gradually become the preferred Profibus application profile. It is usually implemented as a mono-master Profibus network, and is optimised for speed and efficiency. The aim of this paper is to analyse the real-time behaviour of this class of Profibus networks...

Mono-implicit Runge Kutta schemes for singularly perturbed delay differential equations

Science.gov (United States)

Rihan, Fathalla A.; Al-Salti, Nasser S.

2017-09-01

In this paper, we adapt Mono-Implicit Runge-Kutta schemes for numerical approximations of singularly perturbed delay differential equations. The schemes are developed to reduce the computational cost of the fully implicit method which combine the accuracy of implicit method and efficient implementation. Numerical stability properties of the schemes are investigated. Numerical simulations are provided to show the effectiveness of the method for both stiff and non-stiff initial value problems.

High pressure behaviour of uranium mono pnictides

International Nuclear Information System (INIS)

Pagare, Gitanjali; Ojha, Poonam; Sanyal, S.P.; Aynyas, Mahendra

2006-01-01

The pressure induced structural phase transition of three actinide mono pnictides AX (A=U and X=As, Sb, Bi), have been studied theoretically using two body interionic potential with necessary modifications to include the effect of Coulomb screening by the delocalized 5f electrons of the actinide (uranium) ion. The peculiar properties of these compounds have been interpreted in terms of the hybridization of f electrons with the conduction band. The calculated compression curves are compared with the experimental results. These compounds exhibits first order crystallographic phase transition from their NaCl (B 1 ) phase to CsCl (B 2 ) phase at 17GPa, 9.5GPa and 5.3 GPa respectively. The NaCl phase possesses lower energy than CsCl phase and stable at ambient pressure. (author)

Digital Culture and Digital Library

Directory of Open Access Journals (Sweden)

Yalçın Yalçınkaya

2016-12-01

Full Text Available In this study; digital culture and digital library which have a vital connection with each other are examined together. The content of the research consists of the interaction of culture, information, digital culture, intellectual technologies, and digital library concepts. The study is an entry work to integrity of digital culture and digital library theories and aims to expand the symmetry. The purpose of the study is to emphasize the relation between the digital culture and digital library theories acting intersection of the subjects that are examined. Also the perspective of the study is based on examining the literature and analytical evaluation in both studies (digital culture and digital library. Within this context, the methodology of the study is essentially descriptive and has an attribute for the transmission and synthesis of distributed findings produced in the field of the research. According to the findings of the study results, digital culture is an inclusive term that describes the effects of intellectual technologies in the field of information and communication. Information becomes energy and the spectrum of the information is expanding in the vertical rise through the digital culture. In this context, the digital library appears as a new living space of a new environment. In essence, the digital library is information-oriented; has intellectual technology support and digital platform; is in a digital format; combines information resources and tools in relationship/communication/cooperation by connectedness, and also it is the dynamic face of the digital culture in time and space independence. Resolved with the study is that the digital libraries are active and effective in the formation of global knowing and/or mass wisdom in the process of digital culture.

Geochemistry of ikaite formation at Mono Lake, California: Implications for the origin of tufa mounds

Science.gov (United States)

Council, Todd C.; Bennett, Philip C.

1993-11-01

The mineral ikaite (CaCO3 ṡ 6H2O), not previously observed in lake environments, precipitates seasonally along the shore of Mono Lake, California, where Ca-HCO3 spring water mixes with cold Na-CO3 lake water. During the winter, cold water temperatures and high concentrations of PO43- and organic carbon inhibit calcite precipitation, allowing the metastable ikaite to form. During the spring warming, however, ikaite decomposes to form calcium carbonate and water, occasionally leaving pseudomorphs of the primary precipitate. The identification of modern ikaite suggests that both Pleistocene and Holocene tufas in the Mono basin originally precipitated as ikaite. This mineral may also form in other lake environments, but rapid recrystallization after warming destroys the physical, chemical, and isotopic evidence of formation, and alters the geochemical record.

Digital Collections, Digital Libraries & the Digitization of Cultural Heritage Information.

Science.gov (United States)

Lynch, Clifford

2002-01-01

Discusses digital collections and digital libraries. Topics include broadband availability; digital rights protection; content, both non-profit and commercial; digitization of cultural content; sustainability; metadata harvesting protocol; infrastructure; authorship; linking multiple resources; data mining; digitization of reference works;…

Elevated levels of homocysteine increase IL-6 production in monocytic Mono Mac 6 cells

NARCIS (Netherlands)

van Aken, B. E.; Jansen, J.; van Deventer, S. J.; Reitsma, P. H.

2000-01-01

Hyperhomocysteinemia is a risk factor for atherosclerosis and thrombosis. The aim of this study was to analyze if exposure of monocytic cells to increased levels of homocysteine (HCY) induces the accumulation of inflammatory mediators. Interleukin (IL)-6 production by monocytic cell line Mono Mac 6

H. Sapiens Digital: From Digital Immigrants and Digital Natives to Digital Wisdom

Science.gov (United States)

Prensky, Marc

2009-01-01

As we move further into the 21st century, the digital native/digital immigrant paradigm created by Marc Prensky in 2001 is becoming less relevant. In this article, Prensky suggests that we should focus instead on the development of what he calls "digital wisdom." Arguing that digital technology can make us not just smarter but truly wiser, Prensky…

Digital Collections, Digital Libraries and the Digitization of Cultural Heritage Information.

Science.gov (United States)

Lynch, Clifford

2002-01-01

Discusses the development of digital collections and digital libraries. Topics include digitization of cultural heritage information; broadband issues; lack of compelling content; training issues; types of materials being digitized; sustainability; digital preservation; infrastructure; digital images; data mining; and future possibilities for…

Serum metabolomics analysis of patients with chikungunya and dengue mono/co-infections reveals distinct metabolite signatures in the three disease conditions

Science.gov (United States)

Shrinet, Jatin; Shastri, Jayanthi S.; Gaind, Rajni; Bhavesh, Neel Sarovar; Sunil, Sujatha

2016-11-01

Chikungunya and dengue are arboviral infections with overlapping clinical symptoms. A subset of chikungunya infection occurs also as co-infections with dengue, resulting in complications during diagnosis and patient management. The present study was undertaken to identify the global metabolome of patient sera infected with chikungunya as mono infections and with dengue as co-infections. Using nuclear magnetic resonance (NMR) spectroscopy, the metabolome of sera of three disease conditions, namely, chikungunya and dengue as mono-infections and when co-infected were ascertained and compared with healthy individuals. Further, the cohorts were analyzed on the basis of age, onset of fever and joint involvement. Here we show that many metabolites in the serum are significantly differentially regulated during chikungunya mono-infection as well as during chikungunya co-infection with dengue. We observed that glycine, serine, threonine, galactose and pyrimidine metabolisms are the most perturbed pathways in both mono and co-infection conditions. The affected pathways in our study correlate well with the clinical manifestation like fever, inflammation, energy deprivation and joint pain during the infections. These results may serve as a starting point for validations and identification of distinct biomolecules that could be exploited as biomarker candidates thereby helping in better patient management.

Tri-block copolymers with mono-disperse crystallizable diamide segments: synthesis, analysis and rheological properties

NARCIS (Netherlands)

Araichimani, A.; Gaymans, R.J.

2008-01-01

Tri-block copolymers with polyether mid-segments and mono-disperse amide end segments were synthesized, analyzed and some properties studied. The end segment was an aromatic diamide (diaramide, TΦB). The polyether mid-segment was a difunctional poly(tetramethylene oxide) (PTMO, 1000 and 2900 g/mol).

40 CFR 721.3130 - Sulfuric acid, mono-C9-11-alkyl esters, sodium salts.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Sulfuric acid, mono-C9-11-alkyl esters, sodium salts. 721.3130 Section 721.3130 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... significant new uses are: (i) Industrial, commercial, and consumer activities. Requirements as specified in...

Preparation of diesel emulsion using auxiliary emulsifier mono ethylene glycol and utilization in a turbocharged diesel engine

International Nuclear Information System (INIS)

Yilmaz, Emre; Solmaz, Hamit; Polat, Seyfi; Uyumaz, Ahmet; Şahin, Fatih; Salman, M. Sahir

2014-01-01

Highlights: • Mono-ethylene glycol was used as an auxiliary emulsifier. • Using mono ethylene glycol prolonged precipitation duration of emulsions. • With using E5 and E10 fuels engine torque averagely increased by 0.35% and 1.73% respectively. • It was found that specific fuel consumption of emulsions is lower than diesel. • Using E10 fuel reduced CO, NO x and soot emissions 44%, 47% and 5% respectively. - Abstract: Diesel engines are used widely as they have lower fuel consumption and higher thermal efficiency in transportation sector. However, the emitted high NO x , CO and soot emissions have led researchers to search different alternative fuels. At this point, diesel fuels emulsions help to reduce exhaust emissions. In this study, the effects of diesel fuel emulsions containing 5% (E5) and 10% (E10) water on engine performance an exhaust emissions has been investigated. Mono ethylene glycol was used as an auxiliary emulsifier in the preparation of the emulsion. Use of the mono ethylene glycol reduced the subsidence rate of the E5 and E10 about 34.5% and 47.1% respectively. The experiments were conducted at full load condition and at 2500, 3250 and 4000 rpm engine speeds. Engine torque and power increased according to diesel fuel between 2400 and 3600 engine speed range when emulsified fuels were used. But significant reductions were observed after that engine speed range. It was observed that the nitrogenoxide (NO x ) emission reduced 5.42% and 11.01% with using E5 and E10 fuel respectively according to diesel fuel at 2500 rpm. Also the soot emissions reduced 12.39% and 22.97% with using E5 and E10

Mono- and di-n-butyl phosphates of some metals in spent nuclear fuel reprocessing

Energy Technology Data Exchange (ETDEWEB)

Solovkin, A.S.

1982-01-01

Results of investigations which have been carried out in the Soviet Union for the last 10 years on the determination of the composition, structure, conditions of the formation and solubility of mono- and di-n-butyl phosphates of metals (U/sup 6 +/, Pu/sup 4 +/, Pu/sup 3 +/, Th, Zr, Fe/sup 3 +/, Am, Al, rare-earth elements), which are important for the processes of irradiated nuclear fuel reprocessing, are presented. A conclusion is made that zirconium mono- and di-n-butyl phosphates are the least soluble in aqueous and organic solvents of all investigated compounds. FeA/sub 3/ and AmA/sub 3/ are weakly soluble in aqueous solutions. The other compounds are sufficiently soluble in moderately acidic aqueous solutions or in DBP and TBP with dilutents. The obtained results indicate at the similarity of zirconium and plutonium (4) chemical properties; thorium, in this respect, is not an analogue of plutonium (4). Possible structural formulas of the investigated compounds are considered.

PCDFs, PCDDs, non-ortho PCBs, and mono-ortho PCBs in northern fulmars from the Faroe Islands

Energy Technology Data Exchange (ETDEWEB)

Ericson, I.M.; Hagberg, J.; Bavel van, B.; Lindstrom, G. [Orebro Univ., Orebro (Sweden). MTM Research Centre; Dam, M. [Food and Environment Agency, Torshavn, Faroe Islands (Denmark); Jensen, J.K.; Danielsen, J. [Faroese Museum of Natural History, Faroe Islands (Denmark)

2005-07-01

Eggs and tissues of Northern Fulmars have been used to monitor the contamination of the Canadian Arctic marine environment since 1975. Dioxin levels for northern fulmars in the Arctic are among the highest reported for birds. This study reported the results of analyses of dioxins (PCDDs) and non- and mono-ortho polychlorinated biphenyls (PCBs) in liver tissue from juvenile northern fulmars from the Faeroe Islands in 2003. The samples were collected during a traditional hunt and ground with anhydrous sodium sulfate. Sample extraction was performed using supercritical fluid extraction coupled to a solid phase liquid chromatography trap (SFE-LC). Target compounds were collected on a solid phase trap containing AX-21 carbon on ODS silica and eluted with 6 ml n-hexane/dichloromethane for non-planar compounds and xylene for planar compounds. PCDD and planar PCB analysis was performed on an a high resolution gas chromatography (GC) mass spectrometer (MS) operating at 10,000 resolution using EI ionization at 35 eV. Concentrations of PCDFs, PCDDs, non, and mono-ortho PCBs were detected in all samples. High levels of mono-ortho PCBs were detected, as well as non-ortho PCBs, PCDFs, and PCDDs. It was concluded that levels and congener patterns in fulmars from the Faroe Islands and the Canadian Arctic were comparable. However, slightly higher levels were detected in the Faeroe Islands samples. 9 refs., 1 tab., 2 figs.

Health Disparities and Relational Well-Being between Multi- and Mono-Ethnic Asian Americans

Science.gov (United States)

Zhang, Wei

2013-01-01

Focusing on Hawaii, a state with 21.3% of the population being multi-racial according to the 2010 U.S. Census, this study aims to examine the existence and nature of health disparities between mono- and multi-ethnic Asian Americans and the importance of Relational Well-Being in affecting the health of Asian Americans. A series of ordinary least…

Digital Humanities and networked digital media

DEFF Research Database (Denmark)

Finnemann, Niels Ole

2014-01-01

This article discusses digital humanities and the growing diversity of digital media, digital materials and digital methods. The first section describes the humanities computing tradition formed around the interpretation of computation as a rule-based process connected to a concept of digital...... materials centred on the digitisation of non-digital, finite works, corpora and oeuvres. The second section discusses “the big tent” of contemporary digital humanities. It is argued that there can be no unifying interpretation of digital humanities above the level of studying digital materials with the help...... of software-supported methods. This is so, in part, because of the complexity of the world and, in part, because digital media remain open to the projection of new epistemologies onto the functional architecture of these media. The third section discusses the heterogeneous character of digital materials...

Bayesian risk maps for Schistosoma mansoni and hookworm mono-infections in a setting where both parasites co-exist

Directory of Open Access Journals (Sweden)

Giovanna Raso

2007-11-01

Full Text Available There is growing interest in the use of Bayesian geostatistical models for predicting the spatial distribution of parasitic infections, including hookworm, Schistosoma mansoni and co-infections with both parasites. The aim of this study was to predict the spatial distribution of mono-infections with either hookworm or S. mansoni in a setting where both parasites co-exist. School-based cross-sectional parasitological and questionnaire surveys were carried out in 57 rural schools in the Man region, western Côte d’Ivoire. A single stool specimen was obtained from each schoolchild attending grades 3-5. Stool specimens were processed by the Kato-Katz technique and an ether concentration method and examined for the presence of hookworm and S. mansoni eggs. The combined results from the two diagnostic approaches were considered for the infection status of each child. Demographic data (i.e. age and sex were obtained from readily available school registries. Each child’s socio-economic status was estimated, using the questionnaire data following a household-based asset approach. Environmental data were extracted from satellite imagery. The different data sources were incorporated into a geographical information system. Finally, a Bayesian spatial multinomial regression model was constructed and the spatial patterns of S. mansoni and hookworm mono-infections were investigated using Bayesian kriging. Our approach facilitated the production of smooth risk maps for hookworm and S. mansoni mono-infections that can be utilized for targeting control interventions. We argue that in settings where S. mansoni and hookworm co-exist and control efforts are under way, there is a need for both mono- and co-infection risk maps to enhance the cost-effectiveness of control programmes.

Dietary flavonoids bind to mono-ubiquitinated annexin A1 in nuclei, and inhibit chemical induced mutagenesis

Energy Technology Data Exchange (ETDEWEB)

Hirata, Fusao, E-mail: fhirata@wayne.edu; Harada, Takasuke; Corcoran, George B.; Hirata, Aiko

2014-01-15

Highlight: • Nuclear mono-ubiquitinated annexin A1 is involved in DNA damage induced mutagenesis. • Dietary flavonoids bind to and inhibit purified mono-ubiquitinated annexin A1 helicase. • Dietary flavonoids show anti-mutagenic action. • Annexin A1 may serve as a putative target of cancer chemoprevention by flavonoids. - Abstract: In order to investigate the mechanisms of anti-mutagenic action by dietary flavonoids, we investigated if they inhibit mutation of the thymidine kinase (tk) gene in L5178Ytk(±) lymphoma cells. Silibinin, quercetin and genistein suppressed mutation of the tk gene induced in L5178Ytk(±) lymphoma cells by methyl methanesulfonate (MMS) and As{sup 3+}. Flavone and flavonol were less effective. To establish that mutation of the tk gene in L5178Ytk(±) lymphoma cells by MMS and As{sup 3+} is mediated through mono-ubiquitinated annexin A1, L5178Ytk(±) lymphoma cells were treated with annexin A1 anti-sense oligonucleotide. The treatment reduced mRNA as well as protein levels of annexin A1, and suppressed mutation of the tk gene. Nuclear extracts from L5178Ytk(±) lymphoma cells catalyzed translesion DNA synthesis with an oligonucleotide template containing 8-oxo-guanosine in an annexin A1 dependent manner. This translesion DNA synthesis was inhibited by the anti-mutagenic flavonoids, silibinin, quercetin and genistein, in a concentration dependent manner, but only slightly by flavone and flavonol. Because these observations implicate involvement of annexin A1 in mutagenesis, we examined if flavonoids suppress nuclear annexin A1 helicase activity. Silibinin, quercetin and genistein inhibited ssDNA binding, DNA chain annealing and DNA unwinding activities of purified nuclear mono-ubiquitinated annexin A1. Flavone and flavonol were ineffective. The apparent direct binding of anti-mutagenic flavonoids to the annexin A1 molecule was supported by fluorescence quenching. Taken together, these findings illustrate that nuclear annexin A1 may be

Dietary flavonoids bind to mono-ubiquitinated annexin A1 in nuclei, and inhibit chemical induced mutagenesis

International Nuclear Information System (INIS)

Hirata, Fusao; Harada, Takasuke; Corcoran, George B.; Hirata, Aiko

2014-01-01

Highlight: • Nuclear mono-ubiquitinated annexin A1 is involved in DNA damage induced mutagenesis. • Dietary flavonoids bind to and inhibit purified mono-ubiquitinated annexin A1 helicase. • Dietary flavonoids show anti-mutagenic action. • Annexin A1 may serve as a putative target of cancer chemoprevention by flavonoids. - Abstract: In order to investigate the mechanisms of anti-mutagenic action by dietary flavonoids, we investigated if they inhibit mutation of the thymidine kinase (tk) gene in L5178Ytk(±) lymphoma cells. Silibinin, quercetin and genistein suppressed mutation of the tk gene induced in L5178Ytk(±) lymphoma cells by methyl methanesulfonate (MMS) and As 3+ . Flavone and flavonol were less effective. To establish that mutation of the tk gene in L5178Ytk(±) lymphoma cells by MMS and As 3+ is mediated through mono-ubiquitinated annexin A1, L5178Ytk(±) lymphoma cells were treated with annexin A1 anti-sense oligonucleotide. The treatment reduced mRNA as well as protein levels of annexin A1, and suppressed mutation of the tk gene. Nuclear extracts from L5178Ytk(±) lymphoma cells catalyzed translesion DNA synthesis with an oligonucleotide template containing 8-oxo-guanosine in an annexin A1 dependent manner. This translesion DNA synthesis was inhibited by the anti-mutagenic flavonoids, silibinin, quercetin and genistein, in a concentration dependent manner, but only slightly by flavone and flavonol. Because these observations implicate involvement of annexin A1 in mutagenesis, we examined if flavonoids suppress nuclear annexin A1 helicase activity. Silibinin, quercetin and genistein inhibited ssDNA binding, DNA chain annealing and DNA unwinding activities of purified nuclear mono-ubiquitinated annexin A1. Flavone and flavonol were ineffective. The apparent direct binding of anti-mutagenic flavonoids to the annexin A1 molecule was supported by fluorescence quenching. Taken together, these findings illustrate that nuclear annexin A1 may be a novel

Compartmentation of mono- and sesqui-terpene biosynthesis of the essential oil in poncirus trifoliata

International Nuclear Information System (INIS)

Heinrich, G.; Wegener, R.; Schultze, W.

1980-01-01

The fruit of Poncirus trifoliata shows glandular cells complexes in the exocarp, which produce a volatile oil rich in monoterpenes but poor in sesquiterpenes and oxigenated compounds. The juice vesicles of the endocarp possess similar cell complexes mainly containing sesquiterpenes and oxigenated compounds, whereas monoterpenes only occur in small amounts. By the use of combined gas chromatography-mass spectrometry 19 components of the rind oil and 15 compounds of the endocarp oil could be identified. As demonstrated by electron microscopy the terpenes most probably are synthesized predominantly, if not exclusively in plastids. As shown by gasradiochromatography radioactive precursors ( 14 Co 2 and 14 C-leucine) are incorporated into mono- and sesqui-terpenes to a different extent. This is due to two gland types producing essential oils of different composition with regard to their mono- and sesqui-terpene percentage. In fruit development the exocarp glands differentiate earlier than the endocarp glands do. The activity of exogenously applied 14 Co 2 first reaches the peripheral glands and later on appears in the interior glands. Depending upon the growth season, labelled leucine transported by the conducting tissues from lower plant parts leads to a high specific activity of the sesqui-terpenes and oxigenated compounds. It could be argued that in this instance the glands of the pulp are better provided with precursors than the exocarp glands. The successive maxima of essential oil production in both glandular complexes, and the changes in the concentration of individual oil constituents during the ontogeny of the fruit also contribute to different incorporation ratios of radioactive precursors into mono- and sesqui-terpenes. (author)

A mono isocentric radiotherapy technique for craniospinal irradiation using asymmetric jaws

International Nuclear Information System (INIS)

Isin, G; Oezyar, E.; Guerdalli, S.; Arslan, G.; Uzal, D.; Atahan, I. L.

1995-01-01

Dose distribution across the junction of matching of craniospinal fields (lateral cranial fields and posterior spinal field) is important as severe complications may result if the beams overlap or disease may recurs if the gapping is too conservative. Various techniques have been used to achieve an effective transverse plane match and half-beam block technique is one of these techniques. Here, we describe a mono isocentric technique for the treatment of craniospinal fields using the asymmetric jaws of our linear accelerator (Philips SL-25). Before the clinical application of this non-standard technique, basic dosimetry parameters are evaluated. Asymmetric collimator dose distributions for various asymmetric field sizes were obtained and compared with symmetric dose distributions for 6 MV x-ray. A computerized 3-D water phantom with a pair of ionization chambers (reference and field) was used for dose profiles, isodose distributions and Percentage Depth Dose (PDD) for various asymmetric field sizes and different off axis distances. The measured values of off axis ratios for the interested depths were used in MU calculations. This new mono isocentric technique provides an ideal dose distribution at match-line as there is no need to move the patient during treatment. Use of heavy secondary cerrobend blocks (beam splitters) is eliminated. This technique provides the ease of consequent daily set-up's and fulfills the requirements for a conformal radiotherapy

A load-displacement based approach to assess the bearing capacity and deformations of mono-bucket foundations

DEFF Research Database (Denmark)

Vahdatirad, Mohammadjavad; Diaz, Alberto Troya; Nielsen, Søren

2016-01-01

It is now accepted that a larger effort must be made in order to optimize the design so that offshore wind turbines can be competitive with the other energy resources. In this regard, mono-buckets are known as a cost-effective offshore foundation solution. In the current study, a load–displacemen......It is now accepted that a larger effort must be made in order to optimize the design so that offshore wind turbines can be competitive with the other energy resources. In this regard, mono-buckets are known as a cost-effective offshore foundation solution. In the current study, a load...... and run the calculations is proposed. The model is validated, and its accuracy is analyzed, by comparison with field test results for a bucket foundation installed in silty, sandy soil....

Biological significance of lysine mono-, di- and trimethylation on histone and non-histone proteins

International Nuclear Information System (INIS)

Perez-Burgos, L.

2006-01-01

Histones are the proteins that compact DNA into the repeating unit of chromatin known as the nucleosome. The N-termini of histones are subject to a series of post-translational modifications, one of which is methylation. This modification is termed 'epigenetic' because it extends the information encoded in the genome. Lysines can be mono-, di- or tri-methylated at different positions on histones H1, H3 and H4. In order to study the biological role of histone lysine methylation, antibodies were generated against mono-, di- and trimethylated H3-K9 and H3-27. Indeed, different chromatin domains in the mouse nucleus are enriched in distinct forms of histone lysine methylation, such as pericentric heterochromatin and the inactive X chromosome. Interestingly, heterochromatin in Arabidopsis thaliana is enriched in the mono- and di-, but not the trimethylated form of H3-K9. Furthermore, there exists a hierarchy of epigenetic modifications in which H3-K9 trimethylation is found to be upstream of DNA methylation on mouse major satellites. Histone lysine methylation is also involved in gene regulation upon development. One example is the chicken 61538;-globin locus, a region of facultative chromatin that undergoes a loss of di- and trimethylated H3-K27 in mature red blood cells, concomitant with expression of the 61538;-globin genes. SET-domain proteins are enzymes that methylate histones, but some of them are also able to methylate non-histone substrates. In particular, p53 is methylated by Set9 on lysine 372, G9a and Glp-1 on lysine 373 and by Smyd2 on lysine 370. Smyd2 transcript levels are greatly increased upon irradiation and dimethylated p53-370 specifically binds to 53BP1, a protein involved in recognizing DNA double-stranded breaks upon ionizing radiation. These results argue for a novel role of p53-K370 methylation in the biology of DNA damage. In summary, lysine methylation is a post-translational modification that can occur both on histone and non-histone proteins

A low fermentable oligo-di-mono-saccharides and polyols (FODMAP) diet is a balanced therapy for fibromyalgia with nutritional and symptomatic benefits

OpenAIRE

Marum, Ana Paula; Moreira, Cátia; Tomas-Carus, Pablo; Saraiva, Fernando; Guerreiro, Catarina Sousa

2017-01-01

Introduction: Fibromyalgia is a chronic rheumatic disease producing widespread pain, associated to a major comorbidity -irritable bowel syndrome. Low FODMAPS diet (low fermentable oligo-di-mono-saccharides and polyols diet) has been effective in controlling irritable bowel syndrome symptoms. Overweight is an aggravating factor for fibromyalgia. We studied effects of low fermentable oligo-di-mono-saccharides and polyols diets on fibromyalgia symptoms and weight status. Methods: A longitudinal ...

Elimination of Cu (II) and Zn (II) ions in mono-element and the bi ...

African Journals Online (AJOL)

Elimination of Cu (II) and Zn (II) ions in mono-element and the bi-element aqueous solutions by adsorption on natural clay of Bikougou (Gabon) ... The modeling of the experimental results is better achieved by application of. Freundlich adsorption isotherm and Langmuir adsorption isotherm concerning the adsorption of Cu ...

Self-construing in children with primary mono-symptomatic nocturnal enuresis--an investigation of three measures.

Science.gov (United States)

Robinson, Joanne C; Butler, Richard J; Holland, Philip; Doherty-Williams, Dianne

2003-01-01

This study aims to measure different aspects of self-construing in children with primary mono-symptomatic nocturnal enuresis. 25 children aged 7-14 years, with nocturnal enuresis were recruited from a paediatric outpatient's unit specialising in enuresis [mean age 10.6 [males], 9.39 [females

Non-cirrhotic portal hypertension in HIV mono-infected patients.

Science.gov (United States)

Jackson, Belinda D; Doyle, Joseph S; Hoy, Jennifer F; Roberts, Stuart K; Colman, John; Hellard, Margaret E; Sasadeusz, Joseph J; Iser, David M

2012-09-01

Unexplained liver injury including fibrosis and portal hypertension has rarely been reported among patients with HIV in the absence of co-infection with hepatitis B (HBV) or hepatitis C (HCV). We describe a series of HIV mono-infected patients with evidence of non-cirrhotic portal hypertension. HIV-infected patients with evidence of portal hypertension who were anti-HBV and anti-HCV negative and HBV and HCV RNA polymerase chain reaction (PCR) negative were identified from patients managed by the Victorian statewide HIV referral service located at The Alfred Hospital, Melbourne. Portal hypertension was defined as either radiological or endoscopic evidence of varices, portal vein flow obstruction, or elevated hepatic venous pressure gradient (HPVG). Five patients were found to have portal hypertension. These patients were male, aged 41 to 65 years, with known duration of HIV infection between 11 to 25 years. All had been treated with antiretroviral therapy, including didanosine. Tests for metabolic, autoimmune, and hereditary causes of liver disease failed to establish an etiology for the liver injury. All had radiological or endoscopic findings of varices, and four patients had radiological features of portal vein obstruction or flow reversal. Only one patient underwent HPVG measurement, which was elevated. Non-invasive fibrosis assessment revealed increased liver stiffness in three (out of four) patients, and no cirrhotic features were found on those who underwent liver biopsy. To our knowledge, this is the largest published series of non-cirrhotic portal hypertension in HIV mono-infected patients in Australia. Further research is needed to understand what relationship, if any, HIV or its treatments might have on liver injury over time. © 2012 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.

Transient Monotonic and Cyclic Load Effects on Mono Bucket Foundations

DEFF Research Database (Denmark)

Nielsen, Søren Dam

Today, 80 % of all European offshore wind turbines are installed on monopiles. A cost-effective alternative to the monopile is the mono bucket foundation. For an offshore wind turbine foundation in open seas, the dominant load is often coming from waves. During storms, large waves are formed...... the foundation is sucked to the seabed, creating extra capacity during the impact. Over the life-time of an offshore wind turbine foundation will be hit by millions of waves. Each wave might lead to a permanent rotation of the foundation. Therefore, it is important to be able to estimate the total deformation...

Mono-Type TFT Logic Architectures for Low Power Systems on Panel Applications

OpenAIRE

Yang, Yifan; Lee, Sungsik; Holburn, David Michael; Nathan, Arokia

2016-01-01

This paper introduces novel 7-T pseudo-CMOS for enhancement mode and 6-T pseudo-CMOS for depletion mode inverter circuit architectures. The designs are built around mono-type of TFTs and consume less power consumption than existing 4-T pseudo-CMOS circuits. In addition, they provide steep transfer curves, along with embedded control for compensation of device parameter variations. Analysis of the transient behavior for the various circuit architectures is presented, providing quantitative ins...

Elastic source model of the North Mono eruption (1325-1368 A.D.) based on shoreline deformation

Science.gov (United States)

Shaffer, Wil; Bursik, Marcus; Renshaw, Carl

2010-12-01

Topographic data from the Shuttle Radar Topography Mission (SRTM) captures the permanent deformation of a prominent highstand of Mono Lake, California USA. Deformation of the Dechambeau Ranch highstand shoreline was measured using the elevation of the beach berm—shoreline bluff break-in-slope. Point source models and a boundary element dike model were used to approximate the source of deformation underneath the northern end of the Mono Craters. The point source model could not adequately explain the observed deformation. The dike model yielded the best results for a NW trending dike dipping 60° NE and inflated to widths greater than 60 m. The results suggest that the geometry of the source is more complex than a simple vertical dike and that the deformation is better explained with a dipping dike following a normal fault, or an elongated cryptodome.

Anomalous I-V curve for mono-atomic carbon chains

International Nuclear Information System (INIS)

Song Bo; Fang Haiping; Sanvito, Stefano

2010-01-01

The electronic transport properties of mono-atomic carbon chains were studied theoretically using a combination of density functional theory and the non-equilibrium Green's functions method. The I-V curves for the chains composed of an even number of atoms and attached to gold electrodes through sulfur exhibit two plateaus where the current becomes bias independent. In contrast, when the number of carbon atoms in the chain is odd, the electric current simply increases monotonically with bias. This peculiar behavior is attributed to dimerization of the chains, directly resulting from their one-dimensional nature. The finding is expected to be helpful in designing molecular devices, such as carbon-chain-based transistors and sensors, for nanoscale and biological applications.

Conformational studies on pertrimethylsilyl derivatives of some mono- and disaccharides by 220 MHz PMR spectroscopy

NARCIS (Netherlands)

Vliegenthart, J.F.G.; Streefkerk, D.G.; Bie, M.J.A. de

1973-01-01

The complete interpretation of 220 MHz PMR spectra and the accurate chemical shifts and coupling constants, obtained after computer simulation of the spectra, of a number of TMS-mono and -disaccharides are given. By means of an adapted Karplus equation the conformation of the derivatives has been

Comparison study of exhaust plume impingement effects of small mono- and bipropellant thrusters using parallelized DSMC method.

Directory of Open Access Journals (Sweden)

Kyun Ho Lee

Full Text Available A space propulsion system is important for the normal mission operations of a spacecraft by adjusting its attitude and maneuver. Generally, a mono- and a bipropellant thruster have been mainly used for low thrust liquid rocket engines. But as the plume gas expelled from these small thrusters diffuses freely in a vacuum space along all directions, unwanted effects due to the plume collision onto the spacecraft surfaces can dramatically cause a deterioration of the function and performance of a spacecraft. Thus, aim of the present study is to investigate and compare the major differences of the plume gas impingement effects quantitatively between the small mono- and bipropellant thrusters using the computational fluid dynamics (CFD. For an efficiency of the numerical calculations, the whole calculation domain is divided into two different flow regimes depending on the flow characteristics, and then Navier-Stokes equations and parallelized Direct Simulation Monte Carlo (DSMC method are adopted for each flow regime. From the present analysis, thermal and mass influences of the plume gas impingements on the spacecraft were analyzed for the mono- and the bipropellant thrusters. As a result, it is concluded that a careful understanding on the plume impingement effects depending on the chemical characteristics of different propellants are necessary for the efficient design of the spacecraft.

Digital broadcasting

International Nuclear Information System (INIS)

Park, Ji Hyeong

1999-06-01

This book contains twelve chapters, which deals with digitization of broadcast signal such as digital open, digitization of video signal and sound signal digitization of broadcasting equipment like DTPP and digital VTR, digitization of equipment to transmit such as digital STL, digital FPU and digital SNG, digitization of transmit about digital TV transmit and radio transmit, digital broadcasting system on necessity and advantage, digital broadcasting system abroad and Korea, digital broadcasting of outline, advantage of digital TV, ripple effect of digital broadcasting and consideration of digital broadcasting, ground wave digital broadcasting of DVB-T in Europe DTV in U.S.A and ISDB-T in Japan, HDTV broadcasting, satellite broadcasting, digital TV broadcasting in Korea, digital radio broadcasting and new broadcasting service.

Post-middle Miocene Tuffs of Bodie Hills and Mono Basin, California: Paleomagnetic Reference Directions and Vertical Axis Rotation

Science.gov (United States)

Lindeman, J. R.; Pluhar, C. J.; Farner, M. J.

2013-12-01

The relative motions of the Pacific and North American plates about the Sierra Nevada-North American Euler pole is accommodated by dextral slip along the San Andreas Fault System (~75%) and the Walker Lane-Eastern California Shear Zone system of faults, east of the Sierra Nevada microplate (~25%). The Bodie Hills and Mono Basin regions lie within the Walker Lane and partially accommodate deformation by vertical axis rotation of up to 60o rotation since ~9.4 Ma. This region experienced recurrent eruptive events from mid to late Miocene, including John et al.'s (2012) ~12.05 Ma Tuff of Jack Springs (TJS) and Gilbert's (1968) 11.1 - 11.9 Ma 'latite ignimbrite' east of Mono Lake. Both tuffs can be identified by phenocrysts of sanidine and biotite in hand specimens, with TJS composed of a light-grey matrix and the latite ignimbrite composed of a grey-black matrix. Our paleomagnetic results show these units to both be normal polarity, with the latite ignimbrite exhibiting a shallow inclination. TJS's normal polarity is consistent with emplacement during subchron C5 An. 1n (12.014 - 12.116 Ma). The X-ray fluorescence analyses of fiamme from TJS in Bodie Hills and the latite ignimbrite located east of Mono Lake reveal them both to be rhyolites with the latite ignimbrite sharing elevated K composition seen in the slightly younger Stanislaus Group (9.0 - 10.2 Ma). We establish a paleomagnetic reference direction of D = 352.8o I = 42.7o α95 = 7.7o n = 5 sites (42 samples) for TJS in the Bodie Hills in a region hypothesized by Carlson (2012) to have experienced low rotation. Our reference for Gilbert's latite ignimbrite (at Cowtrack Mountain) is D = 352.9o I = 32.1o α95 = 4.7o. This reference locality is found on basement highland likely to have experienced less deformation then the nearby Mono Basin since ignimbrite emplacement. Paleomagnetic results from this latite ignimbrite suggests ~98.2o × 5.5o of clockwise vertical axis rotation of parts of eastern Mono Basin since

Nitrogen fixation dynamics of two diazotrophic communities in Mono Lake, California

Science.gov (United States)

Oremland, R.S.

1990-01-01

Two types of diazotrophic microbial communities were found in the littoral zone of alkaline hypersaline Mono Lake, California. One consisted of anaerobic bacteria inhabiting the flocculent surface layers of sediments. Nitrogen fixation (acetylene reduction) by flocculent surface layers occurred under anaerobic conditions, was not stimulated by light or by additions of organic substrates, and was inhibited by O2, nitrate, and ammonia. The second community consisted of a ball-shaped association of a filamentous chlorophyte (Ctenocladus circinnatus) with diazotrophic, nonheterocystous cyanobacteria, as well as anaerobic bacteria (Ctenocladus balls). Nitrogen fixation by Ctenocladus balls was usually, but not always, stimulated by light. Rates of anaerobic dark fixation equaled those in the light under air. Fixation in the light was stimulated by 3-(3,4-dichlorophenyl)-1,1-dimethylurea and by propanil [N-(3,4-dichlorophenyl)propanamide]. 3-(3,4-Dichlorophenyl)-1,1-dimethyl urea-elicited nitrogenase activity was inhibited by ammonia (96%) and nitrate (65%). Fixation was greatest when Ctenocladus balls were incubated anaerobically in the light with sulfide. Dark anaerobic fixation was not stimulated by organic substrates in short-term (4-h) incubations, but was in long-term (67-h) ones. Areal estimates of benthic N2 fixation were measured seasonally, using chambers. Highest rates (~29.3 ??mol of C2H4 m-2 h-1) occurred under normal diel regimens of light and dark. These estimates indicate that benthic N2 fixation has the potential to be a significant nitrogen source in Mono Lake.

Novel non-viral vectors for gene delivery: synthesis of a second-generation library of mono-functionalized poly-(guanidinium)amines and their introduction into cationic lipids.

Science.gov (United States)

Byk, G; Soto, J; Mattler, C; Frederic, M; Scherman, D

1998-01-01

The development of new gene delivery technologies is a prerequisite towards gene therapy clinical trials. Because gene delivery mediated by viral vectors remains of limited scope due to immunological and propagation risks, the development of new non-viral gene delivery systems is of crucial importance. We have synthesized a secondary library of mono-functionalized poly-(guanidinium)amines generated from a library of mono-functionalized polyamines applying the concept of "libraries from libraries." The method allows a quick and easy access to mono-functionalized geometrically varied poly-(guanidinium)amines. The new building blocks were introduced into cationic lipids to obtain novel poly-(guanidinium)amine lipids, which are potential DNA vectors for gene delivery. Copyright 1998 John Wiley & Sons, Inc.

21 CFR 172.856 - Propylene glycol mono- and diesters of fats and fatty acids.

Science.gov (United States)

2010-04-01

... fatty acids. 172.856 Section 172.856 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... diesters of fats and fatty acids. Propylene glycol mono- and diesters of fats and fatty acids may be safely... and/or fatty acids in compliance with § 172.860 and/or oleic acid derived from tall oil fatty acids in...

Ultrasonication of pyrogenic microorganisms improves the detection of pyrogens in the Mono Mac 6 assay

DEFF Research Database (Denmark)

Moesby, Lise; Hansen, E W; Christensen, J D

2000-01-01

The monocytic cell line Mono Mac 6 is sensitive to pyrogens. When exposed to pyrogens secretion of interleukin-6 is induced. However, some eukaryotic pyrogenic microorganisms are not detectable. The aim of this study is to introduce a pretreatment of samples to expand the detection range of the a...

Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naive HIV-mono-infected and HIV/HCV-co-infected Chinese.

Directory of Open Access Journals (Sweden)

Lai He

Full Text Available Human Immunodeficiency Virus (HIV infection and the resultant Acquired Immunodeficiency Syndrome (AIDS epidemic are major global health challenges; hepatitis C virus (HCV co-infection has made the HIV/AIDS epidemic even worse. Interleukin-27 (IL-27, a cytokine which inhibits HIV and HCV replication in vitro, associates with HIV infection and HIV/HCV co-infection in clinical settings. However, the impact of HIV and HCV viral loads on plasma IL-27 expression levels has not been well characterized. In this study, 155 antiretroviral therapy-naïve Chinese were recruited. Among them 80 were HIV- and HCV-negative healthy controls, 45 were HIV-mono-infected and 30 were HIV/HCV-co-infected. Plasma level HIV, HCV, IL-27 and CD4+ number were counted and their correlation, regression relationships were explored. We show that: plasma IL-27 level was significantly upregulated in HIV-mono-infected and HIV/HCV-co-infected Chinese; HIV viral load was negatively correlated with IL-27 titer in HIV-mono-infected subjects whereas the relationship was opposite in HIV/HCV-co-infected subjects; and the relationships between HIV viral loads, IL-27 titers and CD4+ T cell counts in the HIV mono-infection and HIV/HCV co-infection groups were dramatically different. Overall, our results suggest that IL-27 differs in treatment-naïve groups with HIV mono-infections and HIV/HCV co-infections, thereby providing critical information to be considered when caring and treating those with HIV mono-infection and HIV/HCV co-infection.

A Study on Mono-energetic Beam Source Using Characteristic X-ray for Substance Identification System

International Nuclear Information System (INIS)

Lee, Hwan Soo

2009-02-01

A new mono-energetic beam source was developed by using characteristic X-ray for improving performance of the substance identification system. Most of inspection systems use X-ray tubes for their source modules. However, the broad energy spectrum of X-ray tube causes an increase of uncertainty. In this study, it was found that mono-energetic beam sources can be generated by using X-ray tube and the designed target filter assembly. In order to investigate the monoenergetic beam source, the sensitivity study was conducted with a series of different X-ray tube potentials, radiator and filter materials using Monte Carlo simulation. The developed beam sources have a mono-energy peak at 69 keV, 78 keV and 99 keV, and they are named as characteristic X-ray beam BEAM69, BEAM78 and BEAM99, respectively. The characteristic X-ray beam intensity was over thirty three times more than that of hardening beam used previous work at Hanyang University. And BEAM69 and BEAM99 were applied to the substance identification system as a source. The relative error between results of characteristic X-ray beams and 69 keV and 99 keV photons was about 2% on the average for five unknown materials. In comparison with experiment results by using hardening beam, characteristic X-ray beam achieves better accuracy which is about 6.46 % on the average. Hence, it is expected that the developed characteristic X-ray beam source helps lower uncertainty of the inspection system, and the inspection time will be reduced considerably due to its high beam intensity

Literature review on cyclic lateral loading effects of mono-bucket foundations

DEFF Research Database (Denmark)

Kapitanov, Lachezar Rosenov; Duroska, Peter; Quirante, Cesar Antonio Garcia

2016-01-01

and consequently cost-effectiveness compared to other common solutions. The long-term cyclic loading can cause degradation of soil-bucket system stiffness, which yields into accumulated and permanent deformations. Despite of the advantages, there is no standard procedure to design the foundation especially...... calculation is highly demanded at the different design phases. The intention of the current study is to present, review and summarize the existing techniques to assess the effect of cyclic loading on Mono-Bucket foundations while emphasizing the advantage and disadvantage of each of them. Additionally...

Dynamics of polyelectrolyte adsorption and colloidal flocculation upon mixing studied using mono-dispersed polystyrene latex particles

NARCIS (Netherlands)

Feng, Lili; Cohen Stuart, Martien; Adachi, Yasuhisa

2015-01-01

The dynamic behavior of polyelectrolytes just after their encounter with the surface of bare colloidal particles is analyzed, using the flocculation properties of mono-dispersed polystyrene latex (PSL) particles. Applying a Standardized Colloid Mixing (SCM) approach, effects of ionic strength and

DCS Terrain Submission for Mono, CA

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — Terrain data, as defined in FEMA Guidelines and Specifications, Appendix N: Data Capture Standards, describes the digital topographic data that was used to create...

Forced vibration and wave propagation in mono-coupled periodic structures

DEFF Research Database (Denmark)

Ohlrich, Mogens

1986-01-01

This paper describes the wave propagation and vibration characteristics of mono-coupled structures which are of spatially periodic nature. The receptance approach to periodic structure theory is applied to study undamped periodic systems with composite structural elements; particular emphasis...... and a general `closed form' solution is found for the forced harmonic response at element junctions. This `junction-receptance' is used to determine-discrete junction mode shapes of a finite system. Finally, the forced response of a finite structure with an internal obstruction is derived as a natural extension...... of the determination of the junction-receptance. The influence of such a disorder is illustrated by a simple example...

PERSEPSI GURU TENTANG DIGITAL NATIVES, SUMBER BELAJAR DIGITAL DAN MOTIVASI MEMANFAATKAN SUMBER BELAJAR DIGITAL

Directory of Open Access Journals (Sweden)

Ferdinandus Bate Dopo

2016-06-01

TEACHER’S PERCEPTION OF DIGITAL NATIVES, DIGITAL LEARNING RESOURCES AND MOTIVATION TO UTILIZE DIGITAL LEARNING RESOURCES Abstract This study aims to reveal (1 the influence of teacher's perception of digital natives toward teacher’s motivation to utilize digital learning resources. (2 the influence of teacher's perception of digital learning resources toward teacher’s motivation to utilize digital learning resources and (3 the influence both of teacher's perception of digital natives and digital learning resources toward teacher’s motivation to utilize digital learning resources. This study used the descriptive-correlational quantitative approach. The Population and sample were high school teachers of Regina Pacis Bajawa, SMA Seminari Mataloko and SMA Negeri 1 Golewa. Sampling technique in this research was proportional random sampling. A questionnaire was used to obtain the data. The data were analyzed using the Likert scale. The instrument was developed based on lattice theory of assessment instruments relevant to the study variables. The analysis technique used is a regression followed by statistic technique of t test and F test with the significance level of 0.05. The results are as follows. (1 There is a positive and significant influence of teacher's perception of digital natives toward teacher’s motivation to utilize digital learning resources. (2 There is a positive and significant influence of teacher's perception of digital learning resources and teacher’s motivation to utilize digital learning resources. (3 There is a positive and significant influence both of teacher's perception of digital learning resources and teacher’s motivation to utilize digital learning resources. Keywords: perception, digital natives, digital learning resources, motivation

Single-molecule magnetism in a single-ion triamidoamine uranium(V) terminal mono-oxo complex

International Nuclear Information System (INIS)

King, David M.; McMaster, Jonathan; Lewis, William; Blake, Alexander J.; Liddle, Stephen T.; Tuna, Floriana; McInnes, Eric J.L.

2013-01-01

Straightforward oxidation of a triamidoamine uranium(III) complex with trimethyl-N-oxide affords a uranium(V) terminal mono-oxo complex which is the first clear-cut example of a uranium(V) single-molecule magnet (SMM). This monometallic complex unambiguously shows that a strongly axially ligated and thus anisotropic ligand field can be used to overcome the limited magnetic anisotropy of uranium(V). [de

Mitochondrial membranes with mono- and divalent salt: Changes induced by salt ions on structure and dynamics

NARCIS (Netherlands)

Pöyry, S.; Róg, T.; Karttunen, M.E.J.; Vattulainen, I.

2009-01-01

We employ atomistic simulations to consider how mono- (NaCl) and divalent (CaCl2) salt affects properties of inner and outer membranes of mitochondria. We find that the influence of salt on structural properties is rather minute, only weakly affecting lipid packing, conformational ordering, and

MRI gel dosimetry for verification of mono-isocentric junction doses in head and neck radiotherapy

International Nuclear Information System (INIS)

Back, S.A.J.; Jayasekera, P.M.; Lepage, M.; Baldock, C.; Menzies, N.; Back, P.

2000-01-01

Full text: The use of independent collimators in the abutment of two adjacent treatment volumes, as in head and neck radiation treatments, consists typically of positioning the collimator rotation axis (CRA) at the junction of the volumes, and offsetting each field by its half-field width. This has the effect of positioning one of the collimator jaws at the CRA for each field. However, misalignment of the jaws can lead to variations in dose uniformity in the junction region. We have used gel dosimetry to measure junction doses in three dimensions. PAG gel MRI was used to investigate junction dosimetry for a mono-isocentriic treatment of two orthogonal pairs of opposed (ant/post and lateral) 6 MV x-ray beams. PAG gels in an 11cm diameter cylindrical gel phantom were imaged using a Siemens Vision 1.5 T MRI. The exposures were made using a Philips SL 20 linear accelerator with independent jaws that were known to overlap at the isocentre for sequential abutting offset (within manufacturer's specifications for symmetric fields). X-Omat V films were exposed in mono-directional beams, and optically scanned for comparison. Measurements of off-axis ratios and of relative depth profiles using gel MRI and perpendicular film were in excellent agreement with each other. Measurements through the multi-directional junction at the isocentre are illustrated in the graph, for orthogonal planes centred at the isocentre of the neck phantom. They demonstrate a minimum dose of 75 % of that of the adjacent 'treatment' regions, which agrees closely with the results measured (72%) in the mono-directional case with film. We conclude that this measurement confirms that junction dosimetry at the isocentre measured with perpendicular film for a single direction is a good approximation to the situation in multiple directions. Copyright (2000) Australasian College of Physical Scientists and Engineers in Medicine

E. P. R. spectroscopic study of nitroxide mono- and bi-radicals

International Nuclear Information System (INIS)

Lemaire, H.

1966-09-01

A nitroxide is a molecule containing the group N-O where the oxygen atom made only one bond instead of the usual two. The main advantage of these radicals is their exceptional stability; this allows the study of well defined chemical structures while varying at will the experimental conditions. Studies by electron paramagnetic resonance of nitroxide mono-radicals have given the principal directions and the principal values of the electron-nitrogen nucleus hyperfine tensor and of the anisotropic g-factor tensor. The results were then related to the electronic structure of radicals. An understanding was obtained of the influence of the solvent on the principal values of the tensors, and the marked differences observed in the broadening of hyperfine lines when the medium become viscous. In the nitroxide biradicals, the hyperfine spectra depends not only on the magnetic interactions relative to each monomer, but also on the magnitude of the exchange interaction between the singlet and the triplet states of the dimer; the biradicals studied here are the first organic compounds which show clearly the influence of this exchange on the hyperfine structure. The two unpaired electrons also interact by a magnetic dipolar interaction: in the intermediate case, this can be used to derive the sign of the exchange interaction if the bi-radical is studied in a liquid crystal. Just as for mono-radicals, the hyperfine spectra of bi-radicals show selective broadening in viscous media, which is caused by an overall motional modulation of the anisotropic tensors. This gives another way to determine the sign of the exchange interaction. (author) [fr

Computational fluid dynamics study on mixing mode and power consumption in anaerobic mono- and co-digestion.

Science.gov (United States)

Zhang, Yuan; Yu, Guangren; Yu, Liang; Siddhu, Muhammad Abdul Hanan; Gao, Mengjiao; Abdeltawab, Ahmed A; Al-Deyab, Salem S; Chen, Xiaochun

2016-03-01

Computational fluid dynamics (CFD) was applied to investigate mixing mode and power consumption in anaerobic mono- and co-digestion. Cattle manure (CM) and corn stover (CS) were used as feedstock and stirred tank reactor (STR) was used as digester. Power numbers obtained by the CFD simulation were compared with those from the experimental correlation. Results showed that the standard k-ε model was more appropriate than other turbulence models. A new index, net power production instead of gas production, was proposed to optimize feedstock ratio for anaerobic co-digestion. Results showed that flow field and power consumption were significantly changed in co-digestion of CM and CS compared with those in mono-digestion of either CM or CS. For different mixing modes, the optimum feedstock ratio for co-digestion changed with net power production. The best option of CM/CS ratio for continuous mixing, intermittent mixing I, and intermittent mixing II were 1:1, 1:1 and 1:3, respectively. Copyright © 2016. Published by Elsevier Ltd.

Rapid identification of vibrio-cholerae O1 by coaglutination test using mono-specifis antibody

Directory of Open Access Journals (Sweden)

Bazargan SA

1996-07-01

Full Text Available In our investigation, rabbit hyper-immune serum to V.cholerae ogawa was absorbed with V.cholerae inaba whole-cells and vice versa. Applying ammonium sulphate precipitation method, mono-specific g globulins were purified and concentrated from the absorbed whole serum. These antibodies were fixed on staphylococcus cowan 1 NCTC-8325 whole-cells, using different chemical fixatives. It was observed that maximum fixation of g globulin to protein-A was achieved by 1-propanol 50% at 3 hours, which revealed through single radial immuno-diffusion techniqe. The rectal swab samples were cultured in an enrichment bile-peptons broth. After 5 hours 37°C while agitations, one drop of each sample was mixed with one drop of vibrio-cholerae bivalent mono-specific coagglutination reagent (VBCR. The results were read after 2 to 3 minutes. Finally though statistical analysis sensitivity and specificity of coagglutination test were calculated to be 95.1% and 99.2% respectively, when compared to positive & negative controls and conventional culture methods. Using VBCR, coagglutination test can be therefore considered as a simple, reliable and rapid method to detect V.cholerae O1 in the stool of patients in endemic area and less equipped laboratories

Production of pulse in mono-cropped rice system in the coastal region of Eastern India

International Nuclear Information System (INIS)

Khan, A.R.; Nanda, P.; Chandra, Dinesh; Ghorai, A.K.; Behera, M.S.

2001-04-01

This experiment was undertaken with an objective to increase the yield of black-gram leguminous pulse crop through optimal doses of phosphatic fertilizer with supplemental irrigation in mono-cropped rice-fallow regions of India. Irrigation and phosphorus fertilizer application were introduced for enhancing productivity of black-gram to provide better returns to available water resources

Solvent extraction of uranium(VI), plutonium(VI) and americium(III) with HTTA/HPMBP using mono- and bi-functional neutral donors. Synergism and thermodynamics

International Nuclear Information System (INIS)

Pai, S.A.; Lohithakshan, K.V.; Mithapara, P.D.; Aggarwal, S.K.

2000-01-01

Synergistic extraction of hexavalent uranium and plutonium as well as trivalent americium was studied in HNO 3 with thenoyl, trifluoro-acetone (HTTA)/1-phenyl, 3-methyl, 4-benzoyl pyrazolone-5 (HPMBP) in combination with neutral donors viz. DPSO, TBP, TOPO (mono-functional) and DBDECMP, DHDECMP, CMPO (bi-functional) with wide basicity range using benzene as diluent. A linear correlation was observed when the equilibrium constant log Ks for the organic phase synergistic reaction of both U(VI) and Pu(VI) with either of the chelating agents HTTA or HPMBP was plotted vs. the basicity (log Kh) of the donor (both mono- and bi-functional) indicating bi-functional donors also behave as mono-functional. This was supported by the thermodynamic data (ΔG 0 , ΔH 0 , ΔS 0 ) obtained for these systems. The organic phase adduct formation reactions were identified for the above systems from the thermodynamic data. In the Am(III) HTTA system log K s values of bi-functional donors were found to be very high and deviate from the linear plot (log K s vs. log K h ) obtained for mono-functional donors, indicating that they function as bi-functional for the Am(III)/HTTA) system studied. This was supported by high +ve ΔS 0 values obtained for this system. (author)

N resource of grasses and N2-fixation of alfalfa in mono-culture and mixture

International Nuclear Information System (INIS)

Zhu Shuxiu

1992-01-01

The N behavior in alfalfa and gramineous forage grasses, tall fescue, siberian wild rye, wheat grass and awnless brome were studied in potting and pasture experiments in 1986-1988 by using 15 N isotope dilution technique. Comparison was made between the mixed culture and mono-culture. The % Ndff and %Ndfs of grasses were decreased by 14.19% and 20.76% respectively, while %Ndfa of alfalfa was increased by 20.22% in mixed culture as compared with mono-culture. The 15 N and soil N uptake data revealed that this enhancement was largely due to a lower competitive ability for soil N by alfalfa than by grass in mixed stands, causing the alfalfa to depend more on atmospheric N 2 fixation. 20.62%of N of grasses in mixed culture was from the N 2 -fixation by alfalfa, causing N level in root-sphere of alfalfa decreasing, which was considered to be one of the reasons that %Ndfa increased in mixed culture. N transfer may be carried out by the decomposition of roots and nodules of alfalfa plants

Production of D- and L-Lactic Acid by Mono- and Mixed Cultures of Lactobacillus sp.

Directory of Open Access Journals (Sweden)

Antonija Trontel

2011-01-01

Full Text Available Batch cultivation of monoculture of Lactobacillus sp. and two–strain mixed culture of Lactobacillus sp. and Lactobacillus amylovorus DSM 20531T was carried out with the aim of producing L-(+- and D-(–/L-(+-lactic acid to be implemented in poly(lactic acid polymer production. Metabolic capacity of two Lactobacillus strains to ferment different carbon sources (glucose, sucrose or soluble starch during cultivation in MRS medium at 40 °C, in a laboratory-scale stirred tank bioreactor was defined. Lactobacillus sp. showed similar affinity towards mono- and disaccharide substrates, which were homofermentatively converted mostly to L-(+-lactic acid. L. amylovorus DSM 20531T has been characterized as a D/L-lactate producer and it is capable of conducting simultaneous saccharification and fermentation. Due to the interaction of Lactobacillus sp. with L. amylovorus DSM 20531T, starch was hydrolysed and fermented to the mixture of L-(+- and D-(–-lactic acid. Modified Luedeking-Piret kinetics used for the description of substrate utilization, growth of mono- and mixed cultures and production of lactic acid stereoisomers showed good agreement with experimental data.

On Hydrogen Bonding in the Intramolecularly Chelated Taitomers of Enolic Malondialdehyde and its Mono- and Dithio-Analogues

DEFF Research Database (Denmark)

Carlsen, Lars; Duus, Fritz

1980-01-01

The intramolecular hydrogen bondings in enolic malondialdehyde and it mono- and dithio-analogues have been evaluated by a semiempricial SCF–MO–CNDO method. The calculations predict that the hydrogen bonds play an important part in the stabilities of malondialdehyde and monothiomalondialdehyde...

Mono-jet signatures of gluphilic scalar dark matter

Directory of Open Access Journals (Sweden)

Rohini M. Godbole

2017-09-01

Full Text Available A gluphilic scalar dark matter (GSDM model has recently been proposed as an interesting vision for WIMP dark matter communicating dominantly with the Standard Model via gluons. We discuss the collider signature of a hard jet recoiling against missing momentum (“mono-jet” in such a construction, whose leading contribution is at one-loop. We compare the full one-loop computation with an effective field theory (EFT treatment, and find (as expected that EFT does not accurately describe regions of parameter space where mass of the colored mediator particles are comparable to the experimental cuts on the missing energy. We determine bounds (for several choices of SU(3 representation of the mediator from the s=8 TeV data, and show the expected reach of the s=13 TeV LHC and a future 100 TeV pp collider to constrain or discover GSDM models.

Correlation between the structure and infra-red absorption characteristics of mono-deuterated compounds: contribution to the study of organo-magnesium compounds

International Nuclear Information System (INIS)

Paillous, A.

1965-10-01

The high sensitivity of the ν (C-D) vibration to the variations brought about by the substitution of the carbon attached to the deuterium is shown in the case of organic or organo-metallic mono-deuterated molecules. In particular, syntheses of various mono-deuterated organo-magnesium compounds have been carried out; results are given concerning an infra-red spectrometric examination of these compounds in the range 2100 - 2250 cm -1 . The results show the existence of only one type of deuterated carbon, which suggests that the same carbanion is involved in various ionic associations for the different magnesium-containing compounds. (authors) [fr

Digital Natives or Digital Tribes?

Science.gov (United States)

Watson, Ian Robert

2013-01-01

This research builds upon the discourse surrounding digital natives. A literature review into the digital native phenomena was undertaken and found that researchers are beginning to identify the digital native as not one cohesive group but of individuals influenced by other factors. Primary research by means of questionnaire survey of technologies…

Mechanically flexible optically transparent porous mono-crystalline silicon substrate

KAUST Repository

Rojas, Jhonathan Prieto; Syed, Ahad A.; Hussain, Muhammad Mustafa

2012-01-01

For the first time, we present a simple process to fabricate a thin (≥5μm), mechanically flexible, optically transparent, porous mono-crystalline silicon substrate. Relying only on reactive ion etching steps, we are able to controllably peel off a thin layer of the original substrate. This scheme is cost favorable as it uses a low-cost silicon <100> wafer and furthermore it has the potential for recycling the remaining part of the wafer that otherwise would be lost and wasted during conventional back-grinding process. Due to its porosity, it shows see-through transparency and potential for flexible membrane applications, neural probing and such. Our process can offer flexible, transparent silicon from post high-thermal budget processed device wafer to retain the high performance electronics on flexible substrates. © 2012 IEEE.

Digital platforms as enablers for digital transformation

DEFF Research Database (Denmark)

Hossain, Mokter; Lassen, Astrid Heidemann

transformation is crucial. This study aims at exploring how organizations are driven towards transformation in various ways to embrace digital platforms for ideas, technologies, and knowledge. It shows the opportunities and challenges digital platforms bring in organizations. It also highlights underlying......Digital platforms offer new ways for organizations to collaborate with the external environment for ideas, technologies, and knowledge. They provide new possibilities and competence but they also bring new challenges for organizations. Understanding the role of these platforms in digital...... mechanisms and potential outcomes of various digital platforms. The contribution of the submission is valuable for scholars to understand and further explore this area. It provides insight for practitioners to capture value through digital platforms and accelerate the pace of organizations’ digital...

Digital citizens Digital nations: the next agenda

NARCIS (Netherlands)

A.W. (Bert) Mulder; M.W. (Martijn) Hartog

2015-01-01

DIGITAL CITIZENS CREATE A DIGITAL NATION Citizens will play the lead role as they – in the next phase of the information society – collectively create a digital nation. Personal adoption of information and communication technology will create a digital infrastructure that supports individual and

The assessment of bee venom responses in an experimental model of mono-arthritis using Tc-99m DPD bone scintigraphy

International Nuclear Information System (INIS)

Yang, Chung-Yong; Park, Soon-Ah; Oh, Kyung-Jae; Yang, Yun-Sik

2010-01-01

Several recent studies have shown that bee venom (BV) has an anti-nociceptive and anti-inflammatory effect on arthritis. However, objective methods for evaluation of the therapeutic effect of BV is insufficient in animal studies and clinical trials. Our purpose was to determine the usefulness of bone scintigraphy using Tc-99m DPD (3,3-diphosphono-1,2-propan-dicarbonacid) about effects of BV applied to carrageenan-induced mono-arthritis (CIA) model. Mono-arthritis was induced by an intra-articular injection of carrageenan in Sprague-Dawley rats. Administration of BV (0.8 mg/kg) was performed at 30 min before and at 4 h after the induction of mono-arthritis. We assigned rats to BV-before, BV-after, control-before and control-after groups and compared the results of each group by the weight-loading test and bone scintigraphy. The rats received an intravenous injection of 37 MBq of Tc-99m DPD by the tail vein and then scanning was performed at 4 and 24 h after the injection. Visual assessment and quantitative analysis were performed for both knees. The BV-before and BV-after groups were more improved than the control groups on the weight load test (p<0.05). Bone scintigraphy showed lower activity in the BV-before group than in the control-before group (p<0.05) on the 4 h imaging. However, a significant difference in the BV-before and BV-after groups was not observed on the 24 h imaging. BV had therapeutic effects by anti-nociceptive and anti-inflammatory activity in the CIA and bone scintigraphy performed on 4 h imaging provided visual and quantitative information for the assessment of the therapeutic response to BV as an objective method in mono arthritis model. (author)

A chicory cytochrome P450 mono-oxygenase CYP71AV8 for the oxidation of (+)-valencene

NARCIS (Netherlands)

Cankar, K.; van Houwelingen, A.; Bosch, H.J.; Sonke, T.; Bouwmeester, H.; Beekwilder, J.P.

2011-01-01

Chicory (Cichorium intybus L.), which is known to have a variety of terpene-hydroxylating activities, was screened for a P450 mono-oxygenase to convert (+)-valencene to (+)-nootkatone. A novel P450 cDNA was identified in a chicory root EST library. Co-expression of the enzyme with a valencene

Measurements of the total neutron cross-sections of poly- and mono-germanium crystals at neutron energies below 1 eV

International Nuclear Information System (INIS)

Maayouf, R.M.A.; Abdel-Kawy, A.; Abbas, Y.; Habib, N.; Adib, M.; Hamouda, I.

1983-12-01

Total neutron cross-section measurements have been performed for poly and mono-germanium crystals in the energy range from 2 meV-1eV. The measurements were performed using two TOF and a double axis crystal spectrometer installed at the ET-RR-1 reactor. The obtained neutron cross-sections were analyzed using the single level Breit-Wigner formula. The coherent scattering amplitude was determined from the Bragg reflections observed in the total neutron cross-section of Ge and the analysis of its neutron diffraction pattern. The incoherent and thermal diffuse scattering cross-sections of Ge were estimated from the analysis of the total cross-section data obtained for Ge mono-crystal

Slow neutron total cross-section, transmission and reflection calculation for poly- and mono-NaCl and PbF{sub 2} crystals

Energy Technology Data Exchange (ETDEWEB)

Mansy, Muhammad S., E-mail: mmansy88@asrt.sci.eg [Reactor Physics Department, Nuclear Research Centre, Atomic Energy Authority, Cairo (Egypt); Radioactive Waste Management Unit, Hot Labs Centre, Atomic Energy Authority, Cairo (Egypt); Adib, M.; Habib, N. [Reactor Physics Department, Nuclear Research Centre, Atomic Energy Authority, Cairo (Egypt); Bashter, I.I. [Physics Department, Faculty of Science, Zagazig University (Egypt); Morcos, H.N.; El-Mesiry, M.S. [Reactor Physics Department, Nuclear Research Centre, Atomic Energy Authority, Cairo (Egypt)

2016-10-01

Highlights: • Slow neutron cross-section calculation for poly- and mono-crystalline materials. • Monochromatic features of PbF{sub 2} and NaCl mono-crystals. • Characterization of poly- and mono-crystal filters used in neutron diffraction. • Computer code developed calculates neutron cross-section, transmission & reflection. - Abstract: A detailed study about the calculation of total neutron cross-section, transmission and reflection from crystalline materials was performed. The developed computer code is approved to be sufficient for the required calculations, also an excellent agreement has been shown when comparing the code results with the other calculated and measured values. The optimal monochromator and filter parameters were discussed in terms of crystal orientation, mosaic spread, and thickness. Calculations show that 30 cm thick of PbF{sub 2} poly-crystal is an excellent cold neutron filter producing neutron wavelengths longer than 0.66 nm needed for the investigation of magnetic structure experiments. While mono-crystal filter PbF{sub 2} cut along its (1 1 1), having mosaic spread (η = 0.5°) and thickness 10 cm can only transmit thermal neutrons of the desired wavelengths and suppress epithermal and γ-rays forming unwanted background, when it is cooled to liquid nitrogen temperature. NaCl (2 0 0) and PbF{sub 2} (1 1 1) monochromator crystals having mosaic spread (η = 0.5°) and thickness 10 mm shows high neutron reflectivity for neutron wavelengths (λ = 0.114 nm and λ = 0.43 nm) when they used as a thermal and cold neutron monochromators respectively with very low contamination from higher order reflections.

A comparative hospital-based observational study of mono- and co-infections of malaria, dengue virus and scrub typhus causing acute undifferentiated fever.

Science.gov (United States)

Ahmad, S; Dhar, M; Mittal, G; Bhat, N K; Shirazi, N; Kalra, V; Sati, H C; Gupta, V

2016-04-01

Positive serology for dengue and/or scrub typhus infection with/without positive malarial smear (designated as mixed or co-infection) is being increasingly observed during epidemics of acute undifferentiated febrile illnesses (AUFIs). We planned to study the clinical and biochemical spectrum of co-infections with Plasmodium sp., dengue virus and scrub typhus and compare these with mono-infection by the same organisms. During the period from December 2012 to December 2013, all cases presenting with AUFIs to a single medical unit of a referral centre in Garhwal region of the north Indian state of Uttarakhand were retrospectively selected and categorised aetiologically as co-infections, malaria, dengue or scrub typhus. The groups thus created were compared in terms of demographic, clinical, biochemical and outcome parameters. The co-infection group (n = 49) was associated with milder clinical manifestations, fewer, milder and non-progressive organ dysfunction, and lesser need for intensive care, mechanical ventilation and dialysis as compared to mono-infections. When co-infections were sub-grouped and compared with the relevant mono-infections, there were differences in certain haematological and biochemical parameters; however, this difference did not translate into differential outcomes. Scrub typhus mono-infection was associated with severe disease in terms of both morbidity and mortality. Malaria, dengue and scrub typhus should be routinely tested in all patients with AUFIs. Co-infections, whether true or due to serological cross-reactivity, appear to be a separate entity so far as presentation and morbidity is concerned. Further insight is needed into the mechanism and identification of the protective infection.

Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs.

Science.gov (United States)

Heo, Inha; Ha, Minju; Lim, Jaechul; Yoon, Mi-Jeong; Park, Jong-Eun; Kwon, S Chul; Chang, Hyeshik; Kim, V Narry

2012-10-26

RNase III Drosha initiates microRNA (miRNA) maturation by cleaving a primary miRNA transcript and releasing a pre-miRNA with a 2 nt 3' overhang. Dicer recognizes the 2 nt 3' overhang structure to selectively process pre-miRNAs. Here, we find that, unlike prototypic pre-miRNAs (group I), group II pre-miRNAs acquire a shorter (1 nt) 3' overhang from Drosha processing and therefore require a 3'-end mono-uridylation for Dicer processing. The majority of let-7 and miR-105 belong to group II. We identify TUT7/ZCCHC6, TUT4/ZCCHC11, and TUT2/PAPD4/GLD2 as the terminal uridylyl transferases responsible for pre-miRNA mono-uridylation. The TUTs act specifically on dsRNAs with a 1 nt 3' overhang, thereby creating a 2 nt 3' overhang. Depletion of TUTs reduces let-7 levels and disrupts let-7 function. Although the let-7 suppressor, Lin28, induces inhibitory oligo-uridylation in embryonic stem cells, mono-uridylation occurs in somatic cells lacking Lin28 to promote let-7 biogenesis. Our study reveals functional duality of uridylation and introduces TUT7/4/2 as components of the miRNA biogenesis pathway. Copyright © 2012 Elsevier Inc. All rights reserved.

Aspirin mono-therapy continuation does not result in more bleeding after knee arthroplasty.

Science.gov (United States)

Schwab, Pierre-Emmanuel; Lavand'homme, Patricia; Yombi, JeanCyr; Thienpont, Emmanuel

2017-08-01

Current clinical practice guidelines sometimes still recommend stopping aspirin five to seven days before knee arthroplasty surgery. Literature regarding multimodal blood management and continuation of anti-platelet therapy in this type of surgery is scant. The study hypothesis was that knee arthroplasty under low-dose aspirin mono-therapy continuation does not cause more total blood loss than knee arthroplasty performed without aspirin. Blood loss would be measured by haemoglobin (Hb) and haematocrit (HTC) levels drop at day 2 or day 4 for patients who benefit from multimodal bleeding control measures. A database of all patients undergoing knee arthroplasty between 2006 and 2014 was analysed. Demographic, surgical and complete blood workup data were collected. A retrospective comparison study analysed both groups in terms of blood loss, by mean calculated blood loss as haemoglobin or haematocrit drop between the preoperative Nadir value and the postoperative day 2 and 4 value. A group of 198 (44 UKA and 154 TKA) patients underwent surgery without interrupting their aspirin therapy for cardiovascular prevention. Mean (SD) age was 71 (8) and the mean (SD) BMI was 29 (5.5) kg/m 2 . The control group consisted of 403 (102 UKA and 301 TKA) patients who were not under aspirin, or any other anti-platelet agent. Mean (SD) age was 65 (10) (p aspirin mono-therapy for cardiovascular prevention. III.

Bis(trialkylsilyl) peroxides as alkylating agents in the copper-catalyzed selective mono-N-alkylation of primary amides.

Science.gov (United States)

Sakamoto, Ryu; Sakurai, Shunya; Maruoka, Keiji

2017-06-13

The copper-catalyzed selective mono-N-alkylation of primary amides with bis(trialkylsilyl) peroxides as alkylating agents was reported. The results of a mechanistic study suggest that this reaction should proceed via a free radical process that includes the generation of alkyl radicals from bis(trialkylsilyl) peroxides.

Facile Synthesis of Mono-Dispersed Polystyrene (PS/Ag Composite Microspheres via Modified Chemical Reduction

Directory of Open Access Journals (Sweden)

Wen Zhu

2013-12-01

Full Text Available A modified method based on in situ chemical reduction was developed to prepare mono-dispersed polystyrene/silver (PS/Ag composite microspheres. In this approach; mono-dispersed PS microspheres were synthesized through dispersion polymerization using poly-vinylpyrrolidone (PVP as a dispersant at first. Then, poly-dopamine (PDA was fabricated to functionally modify the surfaces of PS microspheres. With the addition of [Ag(NH32]+ to the PS dispersion, [Ag(NH32]+ complex ions were absorbed and reduced to silver nanoparticles on the surfaces of PS-PDA microspheres to form PS/Ag composite microspheres. PVP acted both as a solvent of the metallic precursor and as a reducing agent. PDA also acted both as a chemical protocol to immobilize the silver nanoparticles at the PS surface and as a reducing agent. Therefore, no additional reducing agents were needed. The resulting composite microspheres were characterized by TEM, field emission scanning electron microscopy (FESEM, energy-dispersive X-ray spectroscopy (EDS, XRD, UV-Vis and surface-enhanced Raman spectroscopy (SERS. The results showed that Ag nanoparticles (NPs were homogeneously immobilized onto the PS microspheres’ surface in the presence of PDA and PVP. PS/Ag composite microspheres were well formed with a uniform and compact shell layer and were adjustable in terms of their optical property.

Digital forensics digital evidence in criminal investigations

CERN Document Server

Marshall, Angus McKenzie

2009-01-01

The vast majority of modern criminal investigations involve some element of digital evidence, from mobile phones, computers, CCTV and other devices. Digital Forensics: Digital Evidence in Criminal Investigations provides the reader with a better understanding of how digital evidence complements "traditional" scientific evidence and examines how it can be used more effectively and efficiently in a range of investigations. Taking a new approach to the topic, this book presents digital evidence as an adjunct to other types of evidence and discusses how it can be deployed effectively in s

Imperfections and phase transformations by mono-N-alkylammonium-uranium glimmers

International Nuclear Information System (INIS)

Kammermeier, H.

1982-01-01

Uranium glimmers have a layered structure. Bimolecular intermediate layered films of parallel ordered alkyl chains can be produced by exchange of the intermediate layer kations with the mono-n-alkylammonium ions and the succession of soaking with n-alkanols. Phase changes can occur in these films that are accompanied by a change of the layer distance of the solid inorganic basic matrix. N-alkyl ammonium-n-alkanol-intercalcation compounds of uranium glimmers represent systems that can conveniently be examined with X-rays. Thermal phase changes can be performed easily. This paper describes how one can derive conclusions on the reaction mechanism of phase changes in bimolecular alkyl chain films by means of a profile analysis of X-ray reflexes. (orig./HBR) [de

Characterization of the crystal orientation in mono-oriented films of HDPE/LLDPE blends by IR dichroism

Energy Technology Data Exchange (ETDEWEB)

Canevarolo, Sebastião V., E-mail: caneva@ufscar.br; Ravazzi, Camila; Silva, Jorge, E-mail: jorge.silva@ufscar.br [Departamento de Engenharia de Materiais, Universidade Federal de São Carlos Rod. Washington Luiz Km 235, 13565-905, SãoCarlos, SP - Brazil (Brazil); Elias, Marcelo [Motechfilm Produtos Plásticos, Estrada Municipal do Bonfim, 100, Pinhal, Cabreúva, SP - Brazil (Brazil)

2016-03-09

Polyethylene films are a common packaging material. The level and type of chain orientation in these films are a very important property which is of great care and concern of the converter personnel during the conformation process. Usually bi-orientation is the conventional procedure but when easy tear in one direction is needed mono-orientation is sought. This paper deal with the characterization of the crystalline orientation in films of polyethylene blends (HDPE/LLDPE) which have being oriented in two steps: initially the polymer was bi-oriented via extrusion-blown, cooled, and then in a second process hot stretched along the machine direction in order to produce mono-oriented films. In order to evaluate the orientation of the film, the polarization of the FT-IR beam was rotated 360° in steps of 5° by rotating the polarizer. In each step the absorbance spectrum was recorded and the corresponding dichroic ratio (DR) calculated after subtracting the baseline. With differential scanning calorimetry (DSC) was possible to infer about the changes in the morphology caused by the stretching.

Digital radiology and digitally formatted image management systems

International Nuclear Information System (INIS)

Cox, G.G.; Dwyer, S.J. III; Templeton, A.W.

1987-01-01

The number of diagnostic examinations performed with digitally formatted imaging equipment is increasing. Digital general-purpose and fluoroscopic radiology systems are being clinically evaluated. Digitizing conventional x-ray films, such as mammograms, frequently improves the diagnostic quality of the images. The digitizing process with laser has also afforded the opportunity to document required spatial resolution for digital imaging and network systems. The use of digitally formatted image instrumentation imposes new requirements on the acquisition, display and manipulation, transmission, hard copy image recording, and archiving of diagnostic data. Networking of digitally formatted image data offers many advantages for managing digital information. This paper identifies and describes digital radiographic systems. Parameters required for designing and implementing a digital image management system are outlined. Spatial and contrast resolution requirements are identified. The key parameters include the amount of image data generated each working day, the retrieval rate of the generated data, the display hardware and software needed for interactive diagnosis display stations, the requirements for analog hard copy generation, and on-line and long-term archiving requirements. These image management systems are often called PACS (Picture Archiving and Communication Systems)

Single-molecule magnetism in a single-ion triamidoamine uranium(V) terminal mono-oxo complex

Energy Technology Data Exchange (ETDEWEB)

King, David M.; McMaster, Jonathan; Lewis, William; Blake, Alexander J.; Liddle, Stephen T. [School of Chemistry, University of Nottingham (United Kingdom); Tuna, Floriana; McInnes, Eric J.L. [School of Chemistry and Photon Science Institute, University of Manchester (United Kingdom)

2013-04-26

Straightforward oxidation of a triamidoamine uranium(III) complex with trimethyl-N-oxide affords a uranium(V) terminal mono-oxo complex which is the first clear-cut example of a uranium(V) single-molecule magnet (SMM). This monometallic complex unambiguously shows that a strongly axially ligated and thus anisotropic ligand field can be used to overcome the limited magnetic anisotropy of uranium(V). (Copyright copyright 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Single-molecule magnetism in a single-ion triamidoamine uranium(V) terminal mono-oxo complex

International Nuclear Information System (INIS)

King, David M.; McMaster, Jonathan; Lewis, William; Blake, Alexander J.; Liddle, Stephen T.; Tuna, Floriana; McInnes, Eric J.L.

2013-01-01

Straightforward oxidation of a triamidoamine uranium(III) complex with trimethyl-N-oxide affords a uranium(V) terminal mono-oxo complex which is the first clear-cut example of a uranium(V) single-molecule magnet (SMM). This monometallic complex unambiguously shows that a strongly axially ligated and thus anisotropic ligand field can be used to overcome the limited magnetic anisotropy of uranium(V). (Copyright copyright 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Empirical mono- versus combination antibiotic therapy in adult intensive care patients with severe sepsis – A systematic review with meta-analysis and trial sequential analysis

DEFF Research Database (Denmark)

Sjövall, Karl Fredrik Lennart; Perner, Anders; Hylander Møller, Morten

2017-01-01

assessment and trial sequential analysis (TSA). We included randomised clinical trials (RCT) assessing empirical mono-antibiotic therapy versus a combination of two or more antibiotics in adult ICU patients with severe sepsis. We exclusively assessed patient-important outcomes, including mortality. Two...... reviewers independently evaluated studies for inclusion, extracted data, and assessed risk of bias. Risk ratios (RRs) with 95% confidence intervals (CIs) were estimated and the risk of random errors was assessed by TSA. Results Thirteen RCTs (n = 2633) were included; all were judged as having high risk...... of bias. Carbapenems were the most frequently used mono-antibiotic (8 of 13 trials). There was no difference in mortality (RR 1.11, 95% CI 0.95–1.29; p = 0.19) or in any other patient-important outcomes between mono- vs. combination therapy. In TSA of mortality, the Z-curve reached the futility area...

Heel effect adaptive flat field correction of digital x-ray detectors

Energy Technology Data Exchange (ETDEWEB)

Yu, Yongjian [X-ray Products, Varian Medical Systems Inc., Liverpool, New York 13088 (United States); Wang, Jue [Department of Mathematics, Union College, Schenectady, New York 12308 (United States)

2013-08-15

Purpose: Anode heel effect renders large-scale background nonuniformities in digital radiographs. Conventional offset/gain calibration is performed at mono source-to-image distance (SID), and disregards the SID-dependent characteristic of heel effect. It results in a residual nonuniform background in the corrected radiographs when the SID settings for calibration and correction differ. In this work, the authors develop a robust and efficient computational method for digital x-ray detector gain correction adapted to SID-variant heel effect, without resorting to physical filters, phantoms, complicated heel effect models, or multiple-SID calibration and interpolation.Methods: The authors present the Duo-SID projection correction method. In our approach, conventional offset/gain calibrations are performed only twice, at the minimum and maximum SIDs of the system in typical clinical use. A fast iterative separation algorithm is devised to extract the detector gain and basis heel patterns from the min/max SID calibrations. The resultant detector gain is independent of SID, while the basis heel patterns are parameterized by the min- and max-SID. The heel pattern at any SID is obtained from the min-SID basis heel pattern via projection imaging principles. The system gain desired at a specific acquisition SID is then constructed using the projected heel pattern and detector gain map.Results: The method was evaluated for flat field and anatomical phantom image corrections. It demonstrated promising improvements over interpolation and conventional gain calibration/correction methods, lowering their correction errors by approximately 70% and 80%, respectively. The separation algorithm was able to extract the detector gain and heel patterns with less than 2% error, and the Duo-SID corrected images showed perceptually appealing uniform background across the detector.Conclusions: The Duo-SID correction method has substantially improved on conventional offset/gain corrections for

Heel effect adaptive flat field correction of digital x-ray detectors

International Nuclear Information System (INIS)

Yu, Yongjian; Wang, Jue

2013-01-01

Purpose: Anode heel effect renders large-scale background nonuniformities in digital radiographs. Conventional offset/gain calibration is performed at mono source-to-image distance (SID), and disregards the SID-dependent characteristic of heel effect. It results in a residual nonuniform background in the corrected radiographs when the SID settings for calibration and correction differ. In this work, the authors develop a robust and efficient computational method for digital x-ray detector gain correction adapted to SID-variant heel effect, without resorting to physical filters, phantoms, complicated heel effect models, or multiple-SID calibration and interpolation.Methods: The authors present the Duo-SID projection correction method. In our approach, conventional offset/gain calibrations are performed only twice, at the minimum and maximum SIDs of the system in typical clinical use. A fast iterative separation algorithm is devised to extract the detector gain and basis heel patterns from the min/max SID calibrations. The resultant detector gain is independent of SID, while the basis heel patterns are parameterized by the min- and max-SID. The heel pattern at any SID is obtained from the min-SID basis heel pattern via projection imaging principles. The system gain desired at a specific acquisition SID is then constructed using the projected heel pattern and detector gain map.Results: The method was evaluated for flat field and anatomical phantom image corrections. It demonstrated promising improvements over interpolation and conventional gain calibration/correction methods, lowering their correction errors by approximately 70% and 80%, respectively. The separation algorithm was able to extract the detector gain and heel patterns with less than 2% error, and the Duo-SID corrected images showed perceptually appealing uniform background across the detector.Conclusions: The Duo-SID correction method has substantially improved on conventional offset/gain corrections for

Digital citizenship and neoliberalization: governing digital citizens in Denmark

DEFF Research Database (Denmark)

Schou, Jannick; Hjelholt, Morten

2018-01-01

Digital citizenship is becoming increasingly normalized within advanced democratic states. As society and governmental institutions become reliant on digital technologies, citizens are expected to be and act digitally. This article examines the governance of digital citizens through a case study...... this case study, the article contributes to current critical perspectives on the digital citizen as a new political figure. It adds new insights into digital citizenship by connecting this figure to wider processes of neoliberalization and state restructuring, pushing for a more pronounced focus...... of digitalization efforts in Denmark. Drawing on multiple forms of data, the article showcases how digital citizens are governed through a combination of discursive, legal and institutional means. The article highlights the political, but also institutional work that goes into making citizens digital. Providing...

Comparing environmental consequences of anaerobic mono- and co-digestion of pig manure to produce bio-energy – A life cycle perspective

DEFF Research Database (Denmark)

De Vries, J.W.; Vinken, T.M.W.J; Hamelin, Lorie

2012-01-01

The aim of this work was to assess the environmental consequences of anaerobic mono- and co-digestion of pig manure to produce bio-energy, from a life cycle perspective. This included assessing environmental impacts and land use change emissions (LUC) required to replace used co-substrates for an...... (up to 568%), but at expense of increasing climate change (through LUC), marine eutrophication, and land use. Codigestion with wastes or residues like roadside grass gave the best environmental performance.......-substrates for anaerobic digestion. Environmental impact categories considered were climate change, terrestrial acidification, marine and freshwater eutrophication, particulate matter formation, land use, and fossil fuel depletion. Six scenarios were evaluated: mono-digestion of manure, co-digestion with: maize silage...

Radiochemical investigations on the decomposition of (mono)methylmercury by means of acid with regard to the determination of total mercury in fish

International Nuclear Information System (INIS)

Harms, U.

1976-01-01

Considerable amounts of mercury in fish muscle tissue are organically bound, i.e. appear as (mono)methylmercury-compounds. In order to make mercury of organic origin available for the determination of total mercury by the 'cold vapour atomic absorption method', a splitting of the carbon-mercury bond by means of suitable chemical treatment must be maintained beforehand. The main subject of this article are investigations with special regard to the behaviour of (mono)methylmercurychloride during different wet digestion methods. The procedures under study involve wet digestion under reflux with HNO 3 , with mixtures of HNO 3 and HClO 4 and HNO 3 and H 2 SO 4 , as well as wet digestion with HNO 3 in a closed system (pressure decomposition). The course of the decomposition of (mono)methylmercury dependent on time, temperature and concentration of reagents are discussed in detail. All experiments were controlled by measurement of the radioactivity of Hg-203 which had been added in the chemical form of CH 3 -Hg-Cl. From the analytical results obtained two methods of sample preparation have been derived that permit a reliable determination of total mercury in fish. (orig.) [de

Mono-colonization with Lactobacillus acidophilus NCFM affects the intestinal metabolome in mice

DEFF Research Database (Denmark)

Roager, Henrik Munch; Sulek, Karolina; Skov, Kasper

(NCFM) on the intestinal metabolome (jejunum, caecum, and colon) in mice by comparing NCFM mono-colonized (MC) mice with GF mice using liquid chromatography coupled to mass-spectrometry (LC-MS). The study adds to existing evidence that NCFM in vivo affects the bile acid signature of mice......-tocopherol acetate) in higher levels in the intestine of GF mice compared to MC mice, suggesting that NCFM either metabolizes the compound or indirectly affects the absorption by changing the metabolome in the intestine. The use of NCFM to increase the uptake of vitamin E supplements in humans and animals...

Digital radiography

International Nuclear Information System (INIS)

Brody, W.R.

1984-01-01

Digital Radiography begins with an orderly introduction to the fundamental concepts of digital imaging. The entire X-ray digital imagining system is described, from an overall characterization of image quality to specific components required for a digital radiographic system. Because subtraction is central to digital radiographic systems, the author details the use of various subtraction methods for image enhancement. Complex concepts are illustrated with numerous examples and presented in terms that can readily be understood by physicians without an advanced mathematics background. The second part of the book discusses implementations and applications of digital imagining systems based on area and scanned detector technologies. This section includes thorough coverage of digital fluoroscopy, scanned projection radiography, and film-based digital imaging systems, and features a state-of-the-art synopsis of the applications of digital subtraction angiography. The book concludes with a timely assessment of anticipated technological advances

Lake Level Changes in the Mono Basin During the Last Deglacial Period

Science.gov (United States)

Wang, X.; Ali, G.; Hemming, S. R.; Zimmerman, S. R. H.; Stine, S. W.; Hemming, G.

2014-12-01

Mono Basin, located in the southwestern corner of the US Great Basin, has long been known to have experienced large lake level changes, particularly during the last deglaciation. But until recently it was not possible to establish a reliable lake level time series. We discovered many visually clean, white, shiny, dense calcite samples in the basin, associated with tufa deposits from high terraces. Their low thorium, but high uranium contents allow precise and reproducible U/Th age determinations. A highly resolved history of a minimum lake level through the last deglaciation can therefore be inferred based on sample locations and their ages. We found that the lake level reached ~2030 m asl at ~20.4 ka, evidenced by calcite coatings on a tufa mound at the upper Wilson Creek. The lake then rose to ~2075 m by ~19.1 ka, shown by calcite cements on conglomerates from the Hansen Cut terrace. The lake climbed to at least ~2140 m at ~15.9 ka, indicated by beach calcites from the east Sierra slope. Such timing of the highest lake stand, occurring within Heinrich Stadial 1, is reinforced by U/Th dates on calcite coatings from widespread locations in the basin, including the Bodie Hills and Cowtrack Mountains. The lake then dropped rapidly to ~2075 m at ~14.5 ka. It stood near this height over the next ~300 years, evidenced by a few-centimeter thick, laminated calcite rims on the Goat Ranch tufa mounds. It subsequently plunged to ~2007 m at ~13.8 ka, indicated by calcite coatings from cemetery road tufa mounds. The lake level came back to ~2030 m at ~12.9 ka, as seen in upper Wilson Creek tufa mounds. The lake level had a few fluctuations within the Younger Dryas, and even shot up to ~2075 m at ~12.0 ka. It then fell to levels in accord with Holocene climatic conditions. Relative to the present lake level of ~1950 m, Mono Lake broadly stood high during Heinrich Stadial 1 and Younger Dryas, when the climate was extremely cold over the North Atlantic, and the Asian monsoon was

Metal–Organic Frameworks Stabilize Mono(phosphine)–Metal Complexes for Broad-Scope Catalytic Reactions

Energy Technology Data Exchange (ETDEWEB)

Sawano, Takahiro; Lin, Zekai; Boures, Dean; An, Bing; Wang, Cheng; Lin, Wenbin (UC); (Xiamen)

2016-08-10

Mono(phosphine)–M (M–PR3; M = Rh and Ir) complexes selectively prepared by postsynthetic metalation of a porous triarylphosphine-based metal–organic framework (MOF) exhibited excellent activity in the hydrosilylation of ketones and alkenes, the hydrogenation of alkenes, and the C–H borylation of arenes. The recyclable and reusable MOF catalysts significantly outperformed their homogeneous counterparts, presumably via stabilizing M–PR3 intermediates by preventing deleterious disproportionation reactions/ligand exchanges in the catalytic cycles.

First-principles study on mono-vacancy self diffusion and recovery in tungsten crystal

International Nuclear Information System (INIS)

Wen, Shu long; Chen, Ji ming; Liu, Xiang; Zhu, Hao; Chang, Hong yan; Huang, Zheng; Pan, Min; Zhao, Yong

2016-01-01

Highlights: • The migration barrier energy E_m of vacancy indicated that the optimum diffusion paths would exist in the diffusion process. • The Frenkel pair’s recovery had a close correlation with the “I–V” distance and within a range of 1.86–2.08 eV. • The self-recovery region has an ellipsoid profile with the semiminor axis of 2.7 Å and the semimajor axis of 5.5 Å. • The probability for the vacancy migration was closely assosiated with the E_m and the working temperature. - Abstract: The point defects behavior becomes one of the most basic issues under the challenge of fusion environment. The recovery mechanisms of Frenkel pair defects and the self-diffusion coefficient of mono-vacancy in bulk bcc tungsten were researched by the first principle calculations. The calculation of migration energy curves for SIAs indicated that the process of the Frenkel pair recovery had a close correlation with the “I–V” distance, and the migration barrier energies E_m was within a limit range of 1.86–2.08 eV. It was found that the self-recovery region had an ellipsoid profile with the semiminor axis of 2.7 Å and the semimajor axis of 5.5 Å. The self-diffusion coefficients of the mono-vacancy were calculated and the results showed that the probability for the vacancy migration was not only associated with the E_m but also the temperature being challenged.

Static and Ultrafast Transient Photophysics of Mono- and Dual-Branched Triarylamines

International Nuclear Information System (INIS)

Feng-Ming, Li; Wen-Ke, Feng; Shu-Feng, Wang; Qi-Huang, Gong; Fan-Shun, Meng; He, Tian

2010-01-01

Mono- and dual-branched molecules, {4-[2-(4-benzothiazol-2-yl-phenyl)-vinyl]-phenyl}-(4-methoxy-phenyl) -phenyl-amine (BS1) and bis-{4-[2-(4-benzothiazol-2-yl-phenyl)-vinyl]-phenyl}-(4-methoxy-phenyl) -phenyl-amine (BS2), are investigated with one- and two-photon static spectroscopy, and the femtosecond fluorescence up-conversion technique. The molecules show branch-based fluorescence emission at low quantum yield. Ultrafast non-radiative decay on a picosecond time scale is found and is attributed to intramolecular charge-transfer bridged by the central triphenylamine. The two-photon absorption cross-sections of BS1 and BS2 are 19.1 and 19.4 GM, respectively. (cross-disciplinary physics and related areas of science and technology)

Digitization

DEFF Research Database (Denmark)

Finnemann, Niels Ole

2014-01-01

what a concept of digital media might add to the understanding of processes of mediatization and what the concept of mediatization might add to the understanding of digital media. It is argued that digital media open an array of new trajectories in human communication, trajectories which were...

The New Digital Divide For Digital BioMarkers.

Science.gov (United States)

Torous, John; Rodriguez, Jorge; Powell, Adam

2017-09-01

As smartphone and sensors continue to become more ubiquitous across the world, digital biomarkers have emerged as a scalable and practical tool to explore disease states and advance health. But as the digital divide of access and ownership begins to fade, a new digital divide is emerging. Who are the types of people that own smartphones or smart watches, who are the types of people that download health apps or partake in digital biomarker studies, and who are the types of people that are actually active with digital biomarkers apps and sensors - the people providing the high quality and longitudinal data that this field is being founded upon? Understanding the people behind digital biomarkers, the very people this emerging field aims to help, may actually be the real challenge as well as opportunity for digital biomarkers.

Metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) in rats: in vivo and in vitro dose and time dependency of metabolism

International Nuclear Information System (INIS)

Lhuguenot, J.C.; Mitchell, A.M.; Milner, G.; Lock, E.A.; Elcombe, C.R.

1985-01-01

This study investigated the in vivo metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate (MEHP) in rats after multiple dosing, the metabolism of MEHP in primary rat hepatocyte cultures for periods of up to 3 days, and the biotransformation of some major metabolites of MEHP. Rats were orally administered [ 14 C]DEHP or [ 14 C]MEHP at doses of 50 and 500 mg/kg body wt for three consecutive days. Urine was collected at 24-hr intervals, and metabolite profiles were determined. After a single dose of either compound, urinary metabolite profiles were similar to those previously reported. However, after multiple administration of both DEHP and MEHP at 500 mg/kg, increases in omega-/beta-oxidation products [metabolites I and V, mono(3-carboxy-2-ethylpropyl) phthalate and mono(5-carboxy-2-ethylpentyl) phthalate, respectively] and decreases in omega - 1-oxidation products [metabolites VI and IX, mono(2-ethyl-5-oxohexyl) phthalate and mono(2-ethyl-5-hydroxyhexyl) phthalate, respectively] were seen. At the low dose of 50 mg/kg little or no alteration in urinary metabolite profiles was observed. At 500 mg/kg of MEHP a 4-fold stimulation of CN- -insensitive palmitoyl-CoA oxidation (a peroxisomal beta-oxidation marker) was seen after three consecutive daily doses. At the low dose of 50 mg/kg only a 1.8-fold increase was noted. Similar observations were made with rat hepatocyte cultures. MEHP at concentrations of 50 and 500 microM was extensively metabolized in the rat hepatocyte cultures. Similar metabolic profiles to those seen after in vivo administration of MEHP were observed. At the high (500 microM) concentration of MEHP, changes in the relative proportions of omega- and omega- 1-oxidized metabolites were seen

Digitization errors using digital charge division positionsensitive detectors

International Nuclear Information System (INIS)

Berliner, R.; Mildner, D.F.R.; Pringle, O.A.

1981-01-01

The data acquisition speed and electronic stability of a charge division position-sensitive detector may be improved by using digital signal processing with a table look-up high speed multiply to form the charge division quotient. This digitization process introduces a positional quantization difficulty which reduces the detector position sensitivity. The degree of the digitization error is dependent on the pulse height spectrum of the detector and on the resolution or dynamic range of the system analog-to-digital converters. The effects have been investigated analytically and by computer simulation. The optimum algorithm for position sensing determination using 8-bit digitization and arithmetic has a digitization error of less than 1%. (orig.)

Fringing in MonoCam Y4 filter images

International Nuclear Information System (INIS)

Brooks, J.; Nomerotski, A.; Fisher-Levine, M.

2017-01-01

We study the fringing patterns observed in MonoCam, a camera with a single Large Synoptic Survey Telescope (LSST) CCD sensor. Images were taken at the U.S. Naval Observatory in Flagstaff, Arizona (NOFS) employing its 1.3 m telescope and an LSST y 4 filter. Fringing occurs due to the reflection of infrared light (700 nm or larger) from the bottom surface of the CCD which constructively or destructively interferes with the incident light to produce a net ''fringe'' pattern which is superimposed on all images taken. Emission lines from the atmosphere, dominated by hydroxyl (OH) spectra, can change in their relative intensities as the night goes on, producing different fringe patterns in the images taken. We found through several methods that the general shape of the fringe patterns remained constant, though with slight changes in the amplitude and phase of the fringes. We also found that a superposition of fringes from two monochromatic lines taken in the lab offered a reasonable description of the sky data.

Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria.

Science.gov (United States)

Korstanje, Ron; Deutsch, Konstantin; Bolanos-Palmieri, Patricia; Hanke, Nils; Schroder, Patricia; Staggs, Lynne; Bräsen, Jan H; Roberts, Ian S D; Sheehan, Susan; Savage, Holly; Haller, Hermann; Schiffer, Mario

2016-11-01

Changes in metabolite levels of the kynurenine pathway have been observed in patients with CKD, suggesting involvement of this pathway in disease pathogenesis. Our recent genetic analysis in the mouse identified the kynurenine 3-mono-oxygenase (KMO) gene (Kmo) as a candidate gene associated with albuminuria. This study investigated this association in more detail. We compared KMO abundance in the glomeruli of mice and humans under normal and diabetic conditions, observing a decrease in glomerular KMO expression with diabetes. Knockdown of kmo expression in zebrafish and genetic deletion of Kmo in mice each led to a proteinuria phenotype. We observed pronounced podocyte foot process effacement on long stretches of the filtration barrier in the zebrafish knockdown model and mild podocyte foot process effacement in the mouse model, whereas all other structures within the kidney remained unremarkable. These data establish the candidacy of KMO as a causal factor for changes in the kidney leading to proteinuria and indicate a functional role for KMO and metabolites of the tryptophan pathway in podocytes. Copyright © 2016 by the American Society of Nephrology.

Analytical Evaluation and Antioxidant Properties of Some Secondary Metabolites in Northern Italian Mono- and Multi-Varietal Extra Virgin Olive Oils (EVOOs) from Early and Late Harvested Olives.

Science.gov (United States)

Trombetta, Domenico; Smeriglio, Antonella; Marcoccia, Daniele; Giofrè, Salvatore Vincenzo; Toscano, Giovanni; Mazzotti, Fabio; Giovanazzi, Angelo; Lorenzetti, Stefano

2017-04-11

The antioxidant activity and the phenolic and α-tocopherol content of 10 Northern Italian mono- and multi-varietal extra virgin olive oils (EVOOs), after early and late olive harvests, was analyzed. A hierarchical cluster analysis was used to evaluate sample similarity. Secoiridoids (SIDs), lignans and flavonoids were the most abundant phenolic compounds identified. The organic Casaliva (among mono-cultivar) and the organic multi-varietal (among blended oils) EVOOs had the higher total phenol content both in early (263.13 and 326.19 mg/kg, respectively) and late harvest (241.88 and 292.34 mg/kg, respectively) conditions. In comparison to late harvest EVOOs, early harvest EVOOs, in particular the organic mono-cultivar Casaliva, showed both higher antioxidant capacity (up to 1285.97 Oxygen Radicals Absorbance Capacity/ORAC units), probably due to the higher SID fraction (54% vs. 40%), and higher α-tocopherol content (up to 280.67 mg/kg). Overall, these results suggest that SIDs and α-tocopherol mainly contribute to antioxidant properties of the studied EVOOs. In light of this, the authors conclude that early harvest, organic mono-cultivar Casaliva EVOO represents the most interesting candidate to explicate healthy effects ascribed to these functional constituents, particularly regarding oxidative stress-related pathologies.

Characteristics of poly- and mono-crystalline BeO and SiO2 as thermal and cold neutron filters

Science.gov (United States)

Adib, M.; Habib, N.; Bashter, I. I.; Morcos, H. N.; El-Mesiry, M. S.; Mansy, M. S.

2015-09-01

A simple model along with a computer code "HEXA-FILTERS" is used to carry out the calculation of the total cross-sections of BeO and SiO2 having poly or mono-crystalline form as a function of neutron wavelength at room (R.T.) and liquid nitrogen (L.N.) temperatures. An overall agreement is indicated between the calculated neutron cross-sections and experimental data. Calculation shows that 25 cm thick of polycrystalline BeO cooled at liquid nitrogen temperature was found to be a good filter for neutron wavelengths longer than 0.46 nm. While, 50 cm of SiO2, with much less transmission, for neutrons with wavelengths longer than 0.85 nm. It was also found that 10 cm of BeO and 15 cm SiO2 thick mono-crystals cut along their (0 0 2) plane, with 0.5° FWHM on mosaic spread and cooled at L.N., are a good thermal neutron filter, with high effect-to-noise ratio.

Research on Digital Product Modeling Key Technologies of Digital Manufacturing

Institute of Scientific and Technical Information of China (English)

DING Guoping; ZHOU Zude; HU Yefa; ZHAO Liang

2006-01-01

With the globalization and diversification of the market and the rapid development of Information Technology (IT) and Artificial Intelligence (AI), the digital revolution of manufacturing is coming. One of the key technologies in digital manufacturing is product digital modeling. This paper firstly analyzes the information and features of the product digital model during each stage in the product whole lifecycle, then researches on the three critical technologies of digital modeling in digital manufacturing-product modeling, standard for the exchange of product model data and digital product data management. And the potential signification of the product digital model during the process of digital manufacturing is concluded-product digital model integrates primary features of each stage during the product whole lifecycle based on graphic features, applies STEP as data exchange mechanism, and establishes PDM system to manage the large amount, complicated and dynamic product data to implement the product digital model data exchange, sharing and integration.

Digital Pulser for Characterization and Diagnostic of Digital Spectrometers

International Nuclear Information System (INIS)

Jordanov, V.T.

2013-01-01

The concept and the realization of the digital pulser are presented. The digital pulser is implemented as a functional block of a digital spectrometer. The digital pulser provides noise free and distortion free measurement of the inherent electronic noise of the entire spectroscopy system. The digital pulser is introduced at the end of the signal processing chain and allows separate evaluation of the individual spectroscopy blocks. It offers the ability to characterize and diagnose problems of the digital pulse height analysers by grounding their inputs. The digital pulser does not interfere with the processing of the detector signals and does not contribute to the dead time and the pulse pile-up of the system. The digital pulser peaks are not affected by the presence of detector pulses and are stored in a separate histogram memory leaving the detector spectrum undistorted. (author)

Digital Ethics/Going Digital.

Science.gov (United States)

Wilson, Bradley

1996-01-01

Finds that the recent National Press Photographers Association code of ethics can serve as a model for any photography staff. Discusses how digital imaging is becoming commonplace in classrooms, due to decreasing costs and easier software. Explains digital terminology. Concludes that time saved in the darkroom and at the printer is now spent on…

A low fermentable oligo-di-mono-saccharides and polyols (FODMAP) diet is a balanced therapy for fibromyalgia with nutritional and symptomatic benefits

Science.gov (United States)

Marum, Ana Paula; Moreira, Cátia; Tomas-Carus, Pablo; Saraiva, Fernando; Guerreiro, Catarina Sousa

2017-06-05

Fibromyalgia is a chronic rheumatic disease producing widespread pain, associated to a major comorbidity -irritable bowel syndrome. Low FODMAPS diet (low fermentable oligo-di-mono-saccharides and polyols diet) has been effective in controlling irritable bowel syndrome symptoms. Overweight is an aggravating factor for fibromyalgia. We studied effects of low fermentable oligo-di-mono-saccharides and polyols diets on fibromyalgia symptoms and weight status. A longitudinal study was performed on 38 fibromyalgia patients using a four-week, repeated assessment as follow: M1 = first assessments/presentation of individual low fermentable oligo-di-mono-saccharides and polyols diet; M2 = second assessments/reintroduction of FODMAPs; M3 = final assessments/nutritional counselling. The assessment instruments applied were: Fibromyalgia Survey Questionnaire (FSQ); Severity Score System (IBS-SSS); visual analogic scale (VAS). Body mass-index/composition and waist circumference (WC) were also measured. Daily macro-micronutrients and FODMAP intake were quantified at each moment of the study. The studied cohort was 37% overweight, 34% obese (average body mass-index 27.4 ± 4.6; excess fat mass 39.4 ± 7%). Weight, body mass-index and waist circumference decreased significantly (p body composition was observed. All fibromyalgiasymptoms, including somatic pain, declined significantly post-LFD (p fibromyalgia [Fibromyalgia survey questionnaire: M1 = 21.8; M2 = 16.9; M3 = 17.0 (p < 0.01)]. The intake of essential nutrients (fiber, calcium, magnesium and vitamin D) showed no significant difference. The significant reduction in FODMAP intake (M1 = 24.4 g; M2 = 2.6g; p < 0.01) reflected the "Diet adherence" (85%). "Satisfaction with improvement of symptoms" (76%), showed correlating with "diet adherence" (r = 0.65; p < 0.01). Results are highly encouraging, showing low fermentable oligo-di-mono-saccharides and polyols diets as a nutritionally balanced approach, contributing to weight loss

Hepatic HMOX1 expression positively correlates with Bach-1 and miR-122 in patients with HCV mono and HIV/HCV coinfection.

Science.gov (United States)

Jabłonowska, Elżbieta; Wójcik, Kamila; Szymańska, Bożena; Omulecka, Aleksandra; Cwiklińska, Hanna; Piekarska, Anna

2014-01-01

To analyze the expression of HMOX1 and miR-122 in liver biopsy samples obtained from HCV mono-and HIV/HCV co-infected patients in relation to selected clinical parameters, histological examination and IL-28B polymorphism as well as to determine whether HMOX1 expression is dependent on Bach-1. The study group consisted of 90 patients with CHC: 69 with HCV mono and 21 with HIV/HCV co-infection. RT-PCR was used in the analysis of HMOX1, Bach-1 and miR-122 expression in liver biopsy samples and in the assessment of IL-28B single-nucleotide polymorphism C/T (rs12979860) in the blood. Moreover in liver biopsy samples an analysis of HO-1 and Bach-1 protein level by Western Blot was performed. HCV mono-infected patients, with lower grading score (G600000 IU/mL) demonstrated higher expression of HMOX1. In patients with HIV/HCV co-infection, the expression of HMOX1 was lower in patients with lower lymphocyte CD4 count and higher HIV viral load. IL28B polymorphism did not affect the expression of either HMOX1 or miR-122. Higher HMOX1 expression correlated with higher expression of Bach-1 (Spearman's ρ = 0.586, p = 0.000001) and miR-122 (Spearman's ρ = 0.270, p = 0.014059). HMOX1 and miR-122 play an important role in the pathogenesis of CHC in HCV mono-and HIV/HCV co-infected patients. Reduced expression of HMOX1 in patients with HIV/HCV co-infection may indicate a worse prognosis in this group. Our results do not support the importance of Bach-1 in repression of HMOX1 in patients with chronic hepatitis C.

Effect of Mono and Di-rhamnolipids on Biofilms Pre-formed by Bacillus subtilis BBK006.

Science.gov (United States)

De Rienzo, Mayri A Díaz; Martin, Peter J

2016-08-01

Different microbial inhibition strategies based on the planktonic bacterial physiology have been known to have limited efficacy on the growth of biofilms communities. This problem can be exacerbated by the emergence of increasingly resistant clinical strains. Biosurfactants have merited renewed interest in both clinical and hygienic sectors due to their potential to disperse microbial biofilms. In this work, we explore the aspects of Bacillus subtilis BBK006 biofilms and examine the contribution of biologically derived surface-active agents (rhamnolipids) to the disruption or inhibition of microbial biofilms produced by Bacillus subtilis BBK006. The ability of mono-rhamnolipids (Rha-C10-C10) produced by Pseudomonas aeruginosa ATCC 9027 and the di-rhamnolipids (Rha-Rha-C14-C14) produced by Burkholderia thailandensis E264, and phosphate-buffered saline to disrupt biofilm of Bacillus subtilis BBK006 was evaluated. The biofilm produced by Bacillus subtilis BBK006 was more sensitive to the di-rhamnolipids (0.4 g/L) produced by Burkholderia thailandensis than the mono-rhamnolipids (0.4 g/L) produced by Pseudomonas aeruginosa ATCC 9027. Rhamnolipids are biologically produced compounds safe for human use. This makes them ideal candidates for use in new generations of bacterial dispersal agents and useful for use as adjuvants for existing microbial suppression or eradication strategies.

Can We Teach Digital Natives Digital Literacy?

Science.gov (United States)

Ng, Wan

2012-01-01

In recent years, there has been much debate about the concept of digital natives, in particular the differences between the digital natives' knowledge and adoption of digital technologies in informal versus formal educational contexts. This paper investigates the knowledge about educational technologies of a group of undergraduate students…

Combined chelation based on glycosyl-mono- and bis-hydroxypyridinones for aluminium mobilization: solution and biodistribution studies.

Science.gov (United States)

Chaves, Sílvia; Dron, Paul I; Danalache, Florina A; Sacoto, Diana; Gano, Lurdes; Santos, M Amélia

2009-11-01

Taking into account the recognized interest of a poly-pharmacological strategy in chelation therapy, a study of aluminium combined chelation based on 3-hydroxy-4-pyridinone (3,4-HP) compounds with complementary properties, associated to different denticity, size and extrafunctionality, is presented herein. In particular, Al-chelation has been explored, using a tetradentate IDA bis-(3,4-HP) ligand, L, and two N-glycosyl mono-(3,4-HP) derivatives (A or B). Combined complexation studies with the tetradentate and the most promising bidentate ligand (A) evidenced the formation of ternary complexes with high thermodynamic stability (Al-L-A) being the predominant species at physiological pH. In vivo studies on the ability for radiotracer ((67)Ga) removal from loaded mice, as a model of aluminium accumulation in body, have shown that the simultaneous administration to (67)Ga-loaded mice of a mono- and a bis-(3,4-HP) chelator (e.g. A and L) leads to a rapid metal elimination from main organs and whole animal model. This may be rationalized by coadjuvation and eventual synergistic effects, due to complementary accessibility of the chelators to different cellular compartments.

Constraining Dark Matter using Mono-X, Dijet, and Dilepton Final States with the ATLAS Detector

CERN Document Server

Tolley, Emma; The ATLAS collaboration

2017-01-01

Weakly-coupled TeV-scale particles may mediate interactions between dark matter (DM) and Standard Model (SM) particles. DM production at colliders may be evident in “mono-X” topologies, and mediator production in in dijet and dilepton events. The latest results obtained by the ATLAS experiment are presented and interpreted following the LHC DM WG guidelines, with particular focus on the complementarity between different collider searches as well as direct detection experiments.

Transitions from mono- to co- to tri-culture uniquely affect gene expression in breast cancer, stromal, and immune compartments.

Science.gov (United States)

Regier, Mary C; Maccoux, Lindsey J; Weinberger, Emma M; Regehr, Keil J; Berry, Scott M; Beebe, David J; Alarid, Elaine T

2016-08-01

Heterotypic interactions in cancer microenvironments play important roles in disease initiation, progression, and spread. Co-culture is the predominant approach used in dissecting paracrine interactions between tumor and stromal cells, but functional results from simple co-cultures frequently fail to correlate to in vivo conditions. Though complex heterotypic in vitro models have improved functional relevance, there is little systematic knowledge of how multi-culture parameters influence this recapitulation. We therefore have employed a more iterative approach to investigate the influence of increasing model complexity; increased heterotypic complexity specifically. Here we describe how the compartmentalized and microscale elements of our multi-culture device allowed us to obtain gene expression data from one cell type at a time in a heterotypic culture where cells communicated through paracrine interactions. With our device we generated a large dataset comprised of cell type specific gene-expression patterns for cultures of increasing complexity (three cell types in mono-, co-, or tri-culture) not readily accessible in other systems. Principal component analysis indicated that gene expression was changed in co-culture but was often more strongly altered in tri-culture as compared to mono-culture. Our analysis revealed that cell type identity and the complexity around it (mono-, co-, or tri-culture) influence gene regulation. We also observed evidence of complementary regulation between cell types in the same heterotypic culture. Here we demonstrate the utility of our platform in providing insight into how tumor and stromal cells respond to microenvironments of varying complexities highlighting the expanding importance of heterotypic cultures that go beyond conventional co-culture.

Influence of asymmetrical mating patterns and male reproductive success on the maintenance of sexual polymorphism in Acer pictum subsp. mono (Aceraceae).

Science.gov (United States)

Shang, Hui; Luo, Yi-Bo; Bai, Wei-Ning

2012-08-01

Populations of Acer species often contain more than three sex phenotypes with complex sexual polymorphism including duodichogamy, protandry and protogyny. We identified the mechanisms that maintain sexual polymorphism in Acer pictum subsp. mono, a temperate tree from northern China, by investigating maternal mating patterns and male reproductive success. We used paternity analyses to estimate rates of outcrossing and disassortative mating, as well as male outcrossed siring success, in a population of A. pictum subsp. mono with uneven sex phenotype ratios (duodichogamous 69.1%, protandrous 19.6%, protogynous 11.3%). We used a pollen-transfer model to investigate whether the unequal ratios of sex phenotypes could be explained by the observed patterns of mating. Most progeny resulted from outcrossing, particularly disassortative among the sex phenotypes. Although the duodichogamous phenotype showed a significant amount of intraphenotypic mating, the frequency did not exceed that of disassortative mating. We detected no significant differences in male outcrossed siring success among the sex phenotypes. The pollen-transfer model demonstrated that sex phenotype ratios could be maintained by the observed mating pattern in the population. Our results indicate that disassortative mating among the sex phenotypes can maintain sexual polymorphism in A. pictum subsp. mono and that ratios biased towards duodichogamy can result from frequent intraphenotypic mating in this phenotype. © 2012 Blackwell Publishing Ltd.

Resveratrol induces cellular senescence with attenuated mono-ubiquitination of histone H2B in glioma cells

International Nuclear Information System (INIS)

Gao, Zhen; Xu, Michael S.; Barnett, Tamara L.; Xu, C. Wilson

2011-01-01

Research highlights: → Resveratrol induces cellular senescence in glioma cell. → Resveratrol inhibits mono-ubiquitination of histone H2B at K120. → Depletion of RNF20, phenocopies the inhibitory effects of resveratrol. → Mono-ubiquitination of histone H2B at K120 is a novel target of resveratrol. → RNF20 inhibits cellular senescence in proliferating glioma cells. -- Abstract: Resveratrol (3,4',5-trihydroxy-trans-stilbene), a polyphenol naturally occurring in grapes and other plants, has cancer chemo-preventive effects and therapeutic potential. Although resveratrol modulates multiple pathways in tumor cells, how resveratrol or its affected pathways converge on chromatin to mediate its effects is not known. Using glioma cells as a model, we showed here that resveratrol inhibited cell proliferation and induced cellular hypertrophy by transforming spindle-shaped cells to enlarged, irregular and flatten-shaped ones. We further showed that resveratrol-induced hypertrophic cells expressed senescence-associated-β-galactosidase, suggesting that resveratrol-induced cellular senescence in glioma cells. Consistent with these observations, we demonstrated that resveratrol inhibited clonogenic efficiencies in vitro and tumor growth in a xenograft model. Furthermore, we found that acute treatment of resveratrol inhibited mono-ubiquitination of histone H2B at K120 (uH2B) in breast, prostate, pancreatic, lung, brain tumor cells as well as primary human cells. Chronic treatment with low doses of resveratrol also inhibited uH2B in the resveratrol-induced senescent glioma cells. Moreover, we showed that depletion of RNF20, a ubiquitin ligase of histone H2B, inhibited uH2B and induced cellular senescence in glioma cells in vitro, thereby recapitulated the effects of resveratrol. Taken together, our results suggest that uH2B is a novel direct or indirect chromatin target of resveratrol and RNF20 plays an important role in inhibiting cellular senescence programs that are

Resveratrol induces cellular senescence with attenuated mono-ubiquitination of histone H2B in glioma cells

Energy Technology Data Exchange (ETDEWEB)

Gao, Zhen; Xu, Michael S.; Barnett, Tamara L. [Nevada Cancer Institute, Las Vegas, NV 89135 (United States); Xu, C. Wilson, E-mail: wxu@nvcancer.org [Nevada Cancer Institute, Las Vegas, NV 89135 (United States)

2011-04-08

Research highlights: {yields} Resveratrol induces cellular senescence in glioma cell. {yields} Resveratrol inhibits mono-ubiquitination of histone H2B at K120. {yields} Depletion of RNF20, phenocopies the inhibitory effects of resveratrol. {yields} Mono-ubiquitination of histone H2B at K120 is a novel target of resveratrol. {yields} RNF20 inhibits cellular senescence in proliferating glioma cells. -- Abstract: Resveratrol (3,4',5-trihydroxy-trans-stilbene), a polyphenol naturally occurring in grapes and other plants, has cancer chemo-preventive effects and therapeutic potential. Although resveratrol modulates multiple pathways in tumor cells, how resveratrol or its affected pathways converge on chromatin to mediate its effects is not known. Using glioma cells as a model, we showed here that resveratrol inhibited cell proliferation and induced cellular hypertrophy by transforming spindle-shaped cells to enlarged, irregular and flatten-shaped ones. We further showed that resveratrol-induced hypertrophic cells expressed senescence-associated-{beta}-galactosidase, suggesting that resveratrol-induced cellular senescence in glioma cells. Consistent with these observations, we demonstrated that resveratrol inhibited clonogenic efficiencies in vitro and tumor growth in a xenograft model. Furthermore, we found that acute treatment of resveratrol inhibited mono-ubiquitination of histone H2B at K120 (uH2B) in breast, prostate, pancreatic, lung, brain tumor cells as well as primary human cells. Chronic treatment with low doses of resveratrol also inhibited uH2B in the resveratrol-induced senescent glioma cells. Moreover, we showed that depletion of RNF20, a ubiquitin ligase of histone H2B, inhibited uH2B and induced cellular senescence in glioma cells in vitro, thereby recapitulated the effects of resveratrol. Taken together, our results suggest that uH2B is a novel direct or indirect chromatin target of resveratrol and RNF20 plays an important role in inhibiting cellular

Controlled Rh-Catalyzed Mono- and Double-decarbonylation of Alkynyl α-Diones To Form Conjugated Ynones and Disubstituted Alkynes.

Science.gov (United States)

Whittaker, Rachel E; Dong, Guangbin

2015-11-06

A Rh-catalyzed controlled decarbonylation of alkynyl α-diones is described. By using different ligand and solvent combinations, mono- and double-decarbonylation can be selectively achieved to give conjugated ynones and disubstituted alkynes, respectively. A fundamental study on catalytic activation of unstrained C-C bonds under nonoxidative conditions is presented.

Mono- and polyadducts of C60 with anthracenes by Diels-Alder-reactions

International Nuclear Information System (INIS)

Duarte-Ruiz, A.

2000-09-01

This work describes the synthesis and characterization of seven new mono-adducts of 9-methylanthracene, 9,10-dimethylanthracene, 9-bromoanthracene. 2,3,6,7-tetramethylanthracene, 1-methylanthracene, 2,6-di-tert-butylanthracen, as well as 2-methylanthracene to fullerene C60 in solution at r.t. by means of [4+2] Diels-Alder reactions. It could be shown that the mono-adducts with 9-methylanthracene, 9,10-dimethylanthracene, and 1-methylanthracene form the corresponding antipodal bis-adduct 'trans-1' on heating the solid to 180 o C. Furthermore the functionalization of fullerene C60 anthracene mono-adduct (C60C14H10) with anthracene through [4+2] Diels-Alder reactions was investigated which made it possible to separate and to characterize the five possible bis-adducts ('trans-1', 'trans-2', 'trans-3', 'trans-4', and 'e') that can form when the second anthracene adds either 'trans' to the opposite hemisphere (compared to the first addition of anthracene) or to an equatorial position. An exact identification of the bis-adducts 'trans-2' and 'trans-4' could only be acquired with spectroscopic methods, fortunately the bis-adducts 'trans-4', 'trans-3', and 'e' could also be examined by x-ray, thus all five could be fully characterized. No bis-adducts on the same hemisphere ('cis') were found. UV/VIS-spectra of the bis-adducts opened up the possibility to identify other [4+2] Diels-Alder products in the future. It has been noticed that the eluation sequence of the bis-adducts ('trans-1' before 'trans-2' before 'trans-4' before 'trans-3' before 'e') doesn't strictly correlate with the dipole moments. Furthermore six new tris-adducts ('t4t4t2', 't3t3t3', 't3t3t4', 'et3t2', 'et3t4', and 'eee') and one tetra-adduct ('eeet3') were separated and characterized. The tris-adduct 't3t3t3' was additionally characterized by x-ray which showed that the crystal contains only one enatiomer. All bis- and tris-adducts form the antipodal bis-adduct 'trans-1' on heating to 180 o C for 10 min

Digitization and digital archiving a practical guide for librarians

CERN Document Server

Leggett, Elizabeth R

2014-01-01

Modern library patrons are embracing the ease with which information can be accessed digitally, and so many librarians are currently working toward making information available electronically. Digitization and Digital Archiving: A Practical Guide for Librarians is a comprehensive guide with step-by-step instructions for forming digital archives.

Digital disruption ?syndromes.

Science.gov (United States)

Sullivan, Clair; Staib, Andrew

2017-05-18

The digital transformation of hospitals in Australia is occurring rapidly in order to facilitate innovation and improve efficiency. Rapid transformation can cause temporary disruption of hospital workflows and staff as processes are adapted to the new digital workflows. The aim of this paper is to outline various types of digital disruption and some strategies for effective management. A large tertiary university hospital recently underwent a rapid, successful roll-out of an integrated electronic medical record (EMR). We observed this transformation and propose several digital disruption "syndromes" to assist with understanding and management during digital transformation: digital deceleration, digital transparency, digital hypervigilance, data discordance, digital churn and post-digital 'depression'. These 'syndromes' are defined and discussed in detail. Successful management of this temporary digital disruption is important to ensure a successful transition to a digital platform. What is known about this topic? Digital disruption is defined as the changes facilitated by digital technologies that occur at a pace and magnitude that disrupt established ways of value creation, social interactions, doing business and more generally our thinking. Increasing numbers of Australian hospitals are implementing digital solutions to replace traditional paper-based systems for patient care in order to create opportunities for improved care and efficiencies. Such large scale change has the potential to create transient disruption to workflows and staff. Managing this temporary disruption effectively is an important factor in the successful implementation of an EMR. What does this paper add? A large tertiary university hospital recently underwent a successful rapid roll-out of an integrated electronic medical record (EMR) to become Australia's largest digital hospital over a 3-week period. We observed and assisted with the management of several cultural, behavioural and

Behavior of the potential-induced degradation of photovoltaic modules fabricated using flat mono-crystalline silicon cells with different surface orientations

Science.gov (United States)

Yamaguchi, Seira; Masuda, Atsushi; Ohdaira, Keisuke

2016-04-01

This paper deals with the dependence of the potential-induced degradation (PID) of flat, p-type mono-crystalline silicon solar cell modules on the surface orientation of solar cells. The investigated modules were fabricated from p-type mono-crystalline silicon cells with a (100) or (111) surface orientation using a module laminator. PID tests were performed by applying a voltage of -1000 V to shorted module interconnector ribbons with respect to an Al plate placed on the cover glass of the modules at 85 °C. A decrease in the parallel resistance of the (100)-oriented cell modules is more significant than that of the (111)-oriented cell modules. Hence, the performance of the (100)-oriented-cell modules drastically deteriorates, compared with that of the (111)-oriented-cell modules. This implies that (111)-oriented cells offer a higher PID resistance.

Digital Natives and Digital Divide: Analysing Perspective for Emerging Pedagogy

Science.gov (United States)

Onye, Uriel U.; Du, Yunfei

2016-01-01

This paper addresses the concepts of digital natives and digital divide from the perspective of the digital outsiders (part of digital natives). It takes a critical look at the implications of available ICT in both developed and underdeveloped countries in the fight against digital divide. The major contribution to literature is by drawing…

First-principles study on mono-vacancy self diffusion and recovery in tungsten crystal

Energy Technology Data Exchange (ETDEWEB)

Wen, Shu long [Key Laboratory of Advanced Technology of Materials (Ministry of Education), Superconductivity and New Energy R& D Ceter, Southwest JiaoTong University, Chengdu, Sichuan 610031 (China); Chen, Ji ming; Liu, Xiang [Fusion Science of Southwestern Institute of Physics, Chengdu, Sichuan 610041 (China); Zhu, Hao; Chang, Hong yan [Key Laboratory of Advanced Technology of Materials (Ministry of Education), Superconductivity and New Energy R& D Ceter, Southwest JiaoTong University, Chengdu, Sichuan 610031 (China); Huang, Zheng, E-mail: zhhuang@swjtu.edu.cn [Key Laboratory of Advanced Technology of Materials (Ministry of Education), Superconductivity and New Energy R& D Ceter, Southwest JiaoTong University, Chengdu, Sichuan 610031 (China); Pan, Min, E-mail: mpan@swjtu.edu.cn [Key Laboratory of Advanced Technology of Materials (Ministry of Education), Superconductivity and New Energy R& D Ceter, Southwest JiaoTong University, Chengdu, Sichuan 610031 (China); Western Superconducting Technologies Co., Ltd., Xi’an, Shanxi 710018 (China); Zhao, Yong [Key Laboratory of Advanced Technology of Materials (Ministry of Education), Superconductivity and New Energy R& D Ceter, Southwest JiaoTong University, Chengdu, Sichuan 610031 (China)

2016-11-01

Highlights: • The migration barrier energy E{sub m} of vacancy indicated that the optimum diffusion paths would exist in the diffusion process. • The Frenkel pair’s recovery had a close correlation with the “I–V” distance and within a range of 1.86–2.08 eV. • The self-recovery region has an ellipsoid profile with the semiminor axis of 2.7 Å and the semimajor axis of 5.5 Å. • The probability for the vacancy migration was closely assosiated with the E{sub m} and the working temperature. - Abstract: The point defects behavior becomes one of the most basic issues under the challenge of fusion environment. The recovery mechanisms of Frenkel pair defects and the self-diffusion coefficient of mono-vacancy in bulk bcc tungsten were researched by the first principle calculations. The calculation of migration energy curves for <111> SIAs indicated that the process of the Frenkel pair recovery had a close correlation with the “I–V” distance, and the migration barrier energies E{sub m} was within a limit range of 1.86–2.08 eV. It was found that the self-recovery region had an ellipsoid profile with the semiminor axis of 2.7 Å and the semimajor axis of 5.5 Å. The self-diffusion coefficients of the mono-vacancy were calculated and the results showed that the probability for the vacancy migration was not only associated with the E{sub m} but also the temperature being challenged.

Digital subtraktion

DEFF Research Database (Denmark)

Mussmann, Bo Redder

2004-01-01

Digital subtraktion er en metode til at fjerne uønskede oplysninger i et røntgenbillede. Subtraktionsteknikken bruges primært i forbindelse med angiografi hvor man kun er interesseret i at se selve karret. Derfor er digital subtraktion i daglig tale synonymt med DSA eller DVI – hhv. Digital...... Subtraction Angiography eller Digital Vascular Imaging. Benævnelserne er to røntgenfirmaers navn for den samme teknik. Digital subtraktion kræver speciel software, samt at apparaturet kan eksponere i serier....

Synthesis, spectroscopic and biological activities studies of acyclic and macrocyclic mono and binuclear metal complexes containing a hard-soft Schiff base.

Science.gov (United States)

Abou-Hussein, Azza A A; Linert, Wolfgang

2012-09-01

Mono- and bi-nuclear acyclic and macrocyclic complexes with hard-soft Schiff base, H(2)L, ligand derived from the reaction of 4,6-diacetylresorcinol and thiocabohydrazide, in the molar ratio 1:2 have been prepared. The H(2)L ligand reacts with Co(II), Ni(II), Cu(II), Zn(II), Mn(II) and UO(2)(VI) nitrates, VO(IV) sulfate and Ru(III) chloride to get acyclic binuclear complexes except for VO(IV) and Ru(III) which gave acyclic mono-nuclear complexes. Reaction of the acyclic mono-nuclear VO(IV) and Ru(III) complexes with 4,6-diacetylresorcinol afforded the corresponding macrocyclic mono-nuclear VO(IV) and Ru(IIII) complexes. Template reactions of the 4,6-diacetylresorcinol and thiocarbohydrazide with either VO(IV) or Ru(III) salts afforded the macrocyclic binuclear VO(IV) and Ru(III) complexes. The Schiff base, H(2)L, ligand acts as dibasic with two NSO-tridentate sites and can coordinate with two metal ions to form binuclear complexes after the deprotonation of the hydrogen atoms of the phenolic groups in all the complexes, except in the case of the acyclic mononuclear Ru(III) and VO(IV) complexes, where the Schiff base behaves as neutral tetradentate chelate with N(2)S(2) donor atoms. The ligands and the metal complexes were characterized by elemental analysis, IR, UV-vis (1)H-NMR, thermal gravimetric analysis (TGA) and ESR, as well as the measurements of conductivity and magnetic moments at room temperature. Electronic spectra and magnetic moments of the complexes indicate the geometries of the metal centers are either tetrahedral, square planar or octahedral. Kinetic and thermodynamic parameters were calculated using Coats-Redfern equation, for the different thermal decomposition steps of the complexes. The ligands and the metal complexes were screened for their antimicrobial activity against Staphylococcus aureus as Gram-positive bacteria, and Pseudomonas fluorescens as Gram-negative bacteria in addition to Fusarium oxysporum fungus. Most of the complexes exhibit

Synthesis, fluorescence properties of Tb(Ⅲ) complexes with novel mono-substituted β-diketone ligands

Institute of Scientific and Technical Information of China (English)

罗一鸣; 李石凤; 李军; 陈学娟; 唐瑞仁

2010-01-01

Two novel pyridine-2,6-dicarboxylic acid derivatives of mono-β-diketone named methyl 6-biphenylacetyl-2-pyridinecarboxylate (MBP) and 6-biphenylacetyl-2-pyridinecarboxylic acid (BAA) and their corresponding binary complexes Tb(MBP)3.6H2O and Tb(BAA)3·6H2O were synthesized. The ligands were characterized by elemental analysis, FT-IR and 1H-NMR, and the complexes were characterized with elemental analysis, FT-IR, 1H-NMR and thermogravimetric and differential thermal analysis(TG-DTA). The investigation of fluo...

Organic geochemistry and brine composition in Great Salt, Mono, and Walker Lakes

Science.gov (United States)

Domagalski, Joseph L.; Orem, W.H.; Eugster, H.P.

1989-01-01

Samples of Recent sediments, representing up to 1000 years of accumulation, were collected from three closed basin lakes (Mono Lake, CA, Walker Lake, NV, and Great Salt Lake, UT) to assess the effects of brine composition on the accumulation of total organic carbon, the concentration of dissolved organic carbon, humic acid structure and diagenesis, and trace metal complexation. The Great Salt Lake water column is a stratified Na-Mg-Cl-SO4 brine with low alkalinity. Algal debris is entrained in the high density (1.132-1.190 g/cc) bottom brines, and in this region maximum organic matter decomposition occurs by anaerobic processes, with sulfate ion as the terminal electron acceptor. Organic matter, below 5 cm of the sediment-water interface, degrades at a very slow rate in spite of very high pore-fluid sulfate levels. The organic carbon concentration stabilizes at 1.1 wt%. Mono Lake is an alkaline (Na-CO3-Cl-SO4) system. The water column is stratified, but the bottom brines are of lower density relative to the Great Salt Lake, and sedimentation of algal debris is rapid. Depletion of pore-fluid sulfate, near l m of core, results in a much higher accumulation of organic carbon, approximately 6 wt%. Walker Lake is also an alkaline system. The water column is not stratified, and decomposition of organic matter occurs by aerobic processes at the sediment-water interface and by anaerobic processes below. Total organic carbon and dissolved organic carbon concentrations in Walker Lake sediments vary with location and depth due to changes in input and pore-fluid sulfate concentrations. Nuclear magnetic resonance studies (13C) of humic substances and dissolved organic carbon provide information on the source of the Recent sedimentary organic carbon (aquatic vs. terrestrial), its relative state of decomposition, and its chemical structure. The spectra suggest an algal origin with little terrestrial signature at all three lakes. This is indicated by the ratio of aliphatic to

Anaerobic halo- alkaliphilic bacterial community of athalassic, hypersaline Mono lake and Owens Lake in California

Science.gov (United States)

Pikuta, Elena V.; Detkova, Ekaterina N.; Bej, Asim K.; Marsic, Damien; Hoover, Richard B.

2003-02-01

The bacterial diversity of microbial extremophiles from the meromictic, hypersaline Mono Lake and a small evaporite pool in Owens Lake of California was studied. In spite of these regions had differing mineral background and different concentrations of NaCl in water they contain the same halo- alkaliphiles anaerobic bacterial community. Three new species of bacteria were detected in this community: primary anaerobe, dissipotrophic saccharolytic spirochete Spirochaeta americana strain AspG1T, primary anaerobe which is proteolytic Tindallia californiensis strain APOT, and secondary anaerobe, hydrogen using Desulfonatronum thiodismutans strain MLF1T, which is sulfate- reducer with chemo-litho-autotrophic metabolism. All of these bacteria are obligate alkaliphiles and dependent upon Na+ ions and CO32- ions in growth mediums. It is interesting that closest relationships for two of these species were isolates from samples of equatorial African soda Magadi lake: Spirochaeta americana AspG1T has 99.4% similarity on 16S rDNA- analyses with Spirochaeta alkalica Z- 7491T, and Tindallia californiensis APOT has 99.1% similarity with Tindallia magadiensis Z-7934T. But result of DNA-DNA- hybridization demonstrated less then 50% similarity between Spirochaeta americana AspG1T and Spirochaeta alkalica Z-7491T. Percent of homology between Tindallia californiensis APOT and Tindallia magadiensis Z-7934T is only 55%. The sulfate-reducer from the alkalic anaerobic community of Magadi lake Desulfonatronovibrio hydrogenovorans Z-7935T was phylogenetically distant from this sulfate-reducer in Mono lake, but genetically closer (99.7% similarity) to the sulfate-reducer, isolated from Central Asian alkalic lake Khadyn in Siberia Desulfonatronum lacustre Z-7951T. The study of key enzymes (hydrogenase and CO- hydrogenase) in Tindallia californiensis APOT and Desulfonatronum thiodismutans MLF1T showed the presence of high activity of both the enzymes in first and only hydrogenase in second

Digital Citizenship Means Character Education for the Digital Age

Science.gov (United States)

Ohler, Jason

2012-01-01

The reality of students' cyber lives has thrust upon educators a new approach: creating character education programs tuned to digital youth that are proactive and aggressive. This will help integrate students' digital activities within the context of the communities in which they live, both local and digital. The digital age beckons a new era of…

Digital Insights

DEFF Research Database (Denmark)

Knudsen, Gry Høngsmark

, by incorporating media as both channel, frame, and apparatus for advertising response, the dissertation brings into attention that more aspects than the text-reader relationship influence ad response. Finally, the dissertation proposes the assemblage approach for exploring big data in consumer culture research...... and practices with digital media, when they meet and interpret advertising. Through studies of advertising response on YouTube and experiments with consumers’ response to digitally manipulated images, the dissertation shows how digital media practices facilitate polysemic and socially embedded advertising......This dissertation forwards the theory of digital consumer-response as a perspective to examine how digital media practices influence consumers’ response to advertising. Digital consumer-response is a development of advertising theory that encompasses how consumers employ their knowledge...

SIMAC - A phosphoproteomic strategy for the rapid separation of mono-phosphorylated from multiply phosphorylated peptides

DEFF Research Database (Denmark)

Thingholm, Tine E; Jensen, Ole N; Robinson, Phillip J

2008-01-01

spectrometric analysis, such as immobilized metal affinity chromatography or titanium dioxide the coverage of the phosphoproteome of a given sample is limited. Here we report a simple and rapid strategy - SIMAC - for sequential separation of mono-phosphorylated peptides and multiply phosphorylated peptides from...... and an optimized titanium dioxide chromatographic method. More than double the total number of identified phosphorylation sites was obtained with SIMAC, primarily from a three-fold increase in recovery of multiply phosphorylated peptides....

Digital information culture the individual and society in the digital age

CERN Document Server

Tredinnick, Luke

2008-01-01

Digital Information Culture is an introduction to the cultural, social and political impact of digital information and digital resources. The book is organised around themes, rather than theories and is arranged into three sections: culture, society and the individual. Each explores key elements of the social, cultural and political impact of digital information. The culture section outlines the origins of cyber culture in fifties pulp-fiction through to the modern day. It explores the issues of information overload, the threat of a digital dark age, and the criminal underbelly of digital culture. Section two, society, explores the economic and social impact of digital information, outlining key theories of the Information Age. Section three explores the impact of digital information and digital resources on the individual, exploring the changing nature of identity in a digital world. Written by a leading author in the field Focuses on digital information and its social, cultural and political impact is uniqu...

Influence of thermal treatment on bentonite used as adsorbent for Cd, Pb, Zn retention from mono-solute and poly-solute aqueous solutions

Directory of Open Access Journals (Sweden)

Susana Yamila Martinez Stagnaro

2012-08-01

Full Text Available The retentions of Zn, Cd and Pb cations by one treated bentonite up to 750 °C were analyzed. The retentions were evaluated by using mono-and poly-solute aqueous solutions of such cations. The adsorptions were carried out in batch system at room temperature. The solid/liquid ratio was 2% wt.v-1. The solids were characterized by X-ray diffraction, thermal and chemical analyses. The Zn cation from mono- or polysolute-solutions was retained in higher amount than Cd and Pb cations in similar solution types by bentonite. The retentions were effective up to 450 °C calcined bentonite, after that, the retention capacity decreased in concordance with dehydroxylation of the structure of clay minerals.

Digital printing

Science.gov (United States)

Sobotka, Werner K.

1997-02-01

Digital printing is described as a tool to replace conventional printing machines completely. Still this goal was not reached until now with any of the digital printing technologies to be described in the paper. Productivity and costs are still the main parameters and are not really solved until now. Quality in digital printing is no problem anymore. Definition of digital printing is to transfer digital datas directly on the paper surface. This step can be carried out directly or with the use of an intermediate image carrier. Keywords in digital printing are: computer- to-press; erasable image carrier; image carrier with memory. Digital printing is also the logical development of the new digital area as it is pointed out in Nicholas Negropotes book 'Being Digital' and also the answer to networking and Internet technologies. Creating images text and color in one country and publishing the datas in another country or continent is the main advantage. Printing on demand another big advantage and last but not least personalization the last big advantage. Costs and being able to coop with this new world of prepress technology is the biggest disadvantage. Therefore the very optimistic growth rates for the next few years are really nonexistent. The development of complete new markets is too slow and the replacing of old markets is too small.

Digital squares

DEFF Research Database (Denmark)

Forchhammer, Søren; Kim, Chul E

1988-01-01

Digital squares are defined and their geometric properties characterized. A linear time algorithm is presented that considers a convex digital region and determines whether or not it is a digital square. The algorithm also determines the range of the values of the parameter set of its preimages....... The analysis involves transforming the boundary of a digital region into parameter space of slope and y-intercept...

Digital skrivedidaktik

DEFF Research Database (Denmark)

Digital skrivedidaktik består af to dele. Første del præsenterer teori om skrivekompetence og digital skrivning. Digital skrivning er karakteriseret ved at tekster skrives på computer og med digitale værktøjer, hvilket ændrer skrivningens traditionelle praksis, produkt og processer. Hvad er digital...... om elevens skriveproces) og Blogskrivning (der styrker eleverne i at bruge blogs i undervisningen)....

Cost Model for Digital Curation: Cost of Digital Migration

DEFF Research Database (Denmark)

Kejser, Ulla Bøgvad; Nielsen, Anders Bo; Thirifays, Alex

2009-01-01

The Danish Ministry of Culture is currently funding a project to set up a model for costing preservation of digital materials held by national cultural heritage institutions. The overall objective of the project is to provide a basis for comparing and estimating future financial requirements...... for digital preservation and to increase cost effectiveness of digital preservation activities. In this study we describe an activity based costing methodology for digital preservation based on the OAIS Reference Model. In order to estimate the cost of digital migrations we have identified cost critical...

Digital preservation

CERN Document Server

Deegan, Marilyn

2013-01-01

Digital preservation is an issue of huge importance to the library and information profession right now. With the widescale adoption of the internet and the rise of the world wide web, the world has been overwhelmed by digital information. Digital data is being produced on a massive scale by individuals and institutions: some of it is born, lives and dies only in digital form, and it is the potential death of this data, with its impact on the preservation of culture, that is the concern of this book. So how can information professionals try to remedy this? Digital preservation is a complex iss

Monojets and mono-photons from light higgsino pair production at LHC14

CERN Document Server

Baer, Howard; Tata, Xerxes

2014-01-01

Naturalness arguments imply the existence of higgsinos lighter than 200-300 GeV. However, because these higgsinos are nearly mass degenerate, they release very little visible energy in their decays, and signals from electroweak higgsino pair production typically remain buried under Standard Model backgrounds. Moreover, gluinos, squarks and winos may plausibly lie beyond the reach of the LHC14, so that signals from naturalness-inspired supersymmetric models may well remain hidden via conventional searches. We examine instead prospects for detecting higgsino pair production via monojets or mono-photons from initial state radiation. We find typical signal-to-background rates at best at the 1 % level, leading to rather pessimistic conclusions regarding detectability via these channels.

Digital academia: How higher education is affected by digital technology

OpenAIRE

Eriksmo, Anton; Sundberg, Johan

2016-01-01

Digital technology in higher education is constantly evolving. Understanding the effects of digital technology is important for higher education institutions in order to make good investments of digital technology. Previous research has focused on learning, teaching or the organization and the relation between one of these aspects and digital technology, thereby missing a broader understanding of how materiality in digital technology affects higher education. In this study themed interviews w...

Digital rights management for digital cinema

Science.gov (United States)

Kirovski, Darko; Peinado, Marcus; Petitcolas, Fabien A. P.

2001-12-01

There is a wide consensus among the feature film production studios that the Internet era brings a new paradigm for film distribution to cinemas worldwide. The benefits of digital cinema to both producers and cinemas are numerous: significantly lower distribution and maintenance costs, immediate access to film libraries, higher presentation quality, and strong potential for developing new business models. Despite these advantages, the studios are still reluctant to jump into the digital age. The main showstopper for digital cinema is the danger of widespread piracy. Piracy already costs Hollywood an estimated two billion dollars annually and digital cinema without proper copyright enforcement could increase this number. In this paper, we present a copyright management system that aims at providing the set of necessary security tools: standard cryptographic primitives and copyright protection mechanisms that enable a reliable and secure feature film delivery system.

Radiometric titration of diethanolamine with 65ZnSO4 and determination of mono and diethanolamines in a mixture by a radiometric method

International Nuclear Information System (INIS)

Varadan, R.; Sriman Narayanan, S.; Rao, V.R.S.

1984-01-01

Radiometric titration of diethanolamine with 65 ZnSO 4 is reported. Determination of individual amounts of mono- and diethanolamines in a mixture is described. The procedure is simple, rapid and accurate. (author)

Cognitive Hacking and Digital Government: Digital Identity

Directory of Open Access Journals (Sweden)

Paul Thompson

2004-04-01

Full Text Available Recently the National Center for Digital Government held a workshop on "The Virtual Citizen: Identity, Autonomy, and Accountability: A Civic Scenario Exploration of the Role of Identity in On-Line. Discussions at the workshop focused on five scenarios for future authentication policies with respect to digital identity. The underlying technologies considered for authentication were: biometrics: cryptography, with a focus on digital signatures; secure processing/computation; and reputation systems. Most discussion at the workshop focused on issues related to authentication of users of digital government, but, as implied by the inclusion of a scenario related to ubiquitous identity theft, there was also discussion of problems related to misinformation, including cognitive hacking. Cognitive hacking refers to a computer or information system attack that relies on changing human users' perceptions and corresponding behaviors in order to succeed. This paper describes cognitive hacking, suggests countermeasures, and discusses the implications of cognitive hacking for identity in digital government. In particular, spoofing of government websites and insider misuse are considered.

Cognitive Hacking and Digital Government: Digital Identity

OpenAIRE

Paul Thompson

2004-01-01

Recently the National Center for Digital Government held a workshop on "The Virtual Citizen: Identity, Autonomy, and Accountability: A Civic Scenario Exploration of the Role of Identity in On-Line. Discussions at the workshop focused on five scenarios for future authentication policies with respect to digital identity. The underlying technologies considered for authentication were: biometrics: cryptography, with a focus on digital signatures; secure processing/computation; and reputation syst...

Digital Natives and Digital Immigrants: Teaching with Technology

Science.gov (United States)

Martin, Ellen Marie Peterson

2011-01-01

Education is witnessing an increasing demand for technology use in the classroom. At the same time, new teachers are entering the profession in high numbers, some being labeled as "Digital Natives" while others are labeled "Digital Immigrants". This qualitative case study investigated the technology practices of Digital Native and Digital…

[Constructing 3-dimensional colorized digital dental model assisted by digital photography].

Science.gov (United States)

Ye, Hong-qiang; Liu, Yu-shu; Liu, Yun-song; Ning, Jing; Zhao, Yi-jiao; Zhou, Yong-sheng

2016-02-18

To explore a method of constructing universal 3-dimensional (3D) colorized digital dental model which can be displayed and edited in common 3D software (such as Geomagic series), in order to improve the visual effect of digital dental model in 3D software. The morphological data of teeth and gingivae were obtained by intra-oral scanning system (3Shape TRIOS), constructing 3D digital dental models. The 3D digital dental models were exported as STL files. Meanwhile, referring to the accredited photography guide of American Academy of Cosmetic Dentistry (AACD), five selected digital photographs of patients'teeth and gingivae were taken by digital single lens reflex camera (DSLR) with the same exposure parameters (except occlusal views) to capture the color data. In Geomagic Studio 2013, after STL file of 3D digital dental model being imported, digital photographs were projected on 3D digital dental model with corresponding position and angle. The junctions of different photos were carefully trimmed to get continuous and natural color transitions. Then the 3D colorized digital dental model was constructed, which was exported as OBJ file or WRP file which was a special file for software of Geomagic series. For the purpose of evaluating the visual effect of the 3D colorized digital model, a rating scale on color simulation effect in views of patients'evaluation was used. Sixteen patients were recruited and their scores on colored and non-colored digital dental models were recorded. The data were analyzed using McNemar-Bowker test in SPSS 20. Universal 3D colorized digital dental model with better color simulation was constructed based on intra-oral scanning and digital photography. For clinical application, the 3D colorized digital dental models, combined with 3D face images, were introduced into 3D smile design of aesthetic rehabilitation, which could improve the patients' cognition for the esthetic digital design and virtual prosthetic effect. Universal 3D colorized

The stability of mandibular prognathism corrected by bilateral sagittal split osteotomies: a comparison of bi-cortical osteosynthesis and mono-cortical osteosynthesis.

Science.gov (United States)

Hsu, S S-P; Huang, C-S; Chen, P K-T; Ko, E W-C; Chen, Y-R

2012-02-01

This study evaluated the differences in surgical changes and post-surgical changes between bi-cortical and mono-cortical osteosynthesis (MCO) in the correction of skeletal Class III malocclusion with bilateral sagittal split osteotomies (BSSOs). Twenty-five patients had bi-cortical osteosynthesis (BCO), 32 patients had mono-cortical fixation. Lateral and postero-anterior cephalometric radiographs, taken at the time of surgery, before surgery, 1 month after surgery, and on completion of orthodontic treatment (mean 9.9 months after surgery), were obtained for evaluation. Cephalometric analysis and superimposition were used to investigate the surgical and post-surgical changes. Independent t-test was performed to compare the difference between the two groups. Pearson's correlations were tested to evaluate the factors related to the relapse of the mandible. The sagittal relapse rate was 20% in the bi-cortical and 25% in the mono-cortical group. The forward-upward rotation of the mandible in the post-surgical period contributed most of the sagittal relapse. There were no statistically significant differences in sagittal and vertical changes between the two groups during surgery and in the post-surgical period. No factors were found to correlate with post-surgical relapse, but the intergonial width increased more in the bi-cortical group. The study suggested that both methods of skeletal fixation had similar postoperative stability. Copyright © 2011 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Dynamic Covalent Self-Assembly of Mono-, Bi- and Trimacro-cycles from Hydrogen Bonded Preorganized Templates

Institute of Scientific and Technical Information of China (English)

LIN Jianbin; WU Jing; JIANG Xikui; LI Zhanting

2009-01-01

This paper describes the dynamic covalent assembly of three mono-, bi- and trimacrocycles by utilizing hydro-gen bonding-driven zigzag anthranilamides as "leading" components. The monomacrocycle, a tetraamino molecule, was prepared from the [24+2] coupling reaction of a "'U"-shaped dialdehyde and a porphyrin diamine, followed by the reduction of the macrocyclic tetraimine by NaBH3CN, while the bi-and trimacrocycles were obtained through two six-component coupling reactions with rigid tri- and tetraamino-appended oligomers as templates.

Microwave Photocatalysis of Mono-Chloroacetic Acid over Nanoporous Titanium(IV) Oxide Thin Films Using Mercury Electrodeless Discharge Lamps

Czech Academy of Sciences Publication Activity Database

Církva, Vladimír; Žabová, Hana; Hájek, Milan

2008-01-01

Roč. 198, č. 1 (2008), s. 13-17 ISSN 1010-6030 R&D Projects: GA ČR GA104/06/0992; GA ČR GA104/07/1212 Institutional research plan: CEZ:AV0Z40720504 Keywords : microwave-assisted photocatalysis * electrodeless discharge lamp * mono-chloroacetic acid Subject RIV: CH - Nuclear ; Quantum Chemistry Impact factor: 2.362, year: 2008

The use of approximation formulae in calculations of acid-base equilibria-II: salts of mono- and diprotic acids.

Science.gov (United States)

Narasaki, H

1980-02-01

The pH of solutions of salts of mono- and diprotic acids is calculated by use of approximation formulae and the theoretically exact equations. The regions for useful application of the approximation formulae (error monoprotic acids, areas are symmetrically equal to those of the acids. For salts of diprotic acids the ranges generally depend on K(2)/K(1).

PEMBERDAYAAN MASYARAKAT KEPULAUAN TALANGO KABUPATEN SUMENEP MELALUI USAHA PERCETAKAN DAN SABLON DIGITAL PRINTING

Directory of Open Access Journals (Sweden)

Budi Dwi Satoto

2014-08-01

Full Text Available The role of youth in development is very important because it is considered to be in the productive age to support various development activities in various sectors. Most youth can be absorbed in the labor market, and partly eliminated from the competition and become a static group. Not a few who engage in the business world ranging from the small to large, one form of business that is highly demanded by the youth is the Small and Medium Enterprises and Silk Screen Printing. However, the form of efforts among youth most still use manual design and printing due to lack of capital and expertise. With this activity, try to solve them with IBM is working with partners Silk Screen Printing Industry centers in villages Talango, Talango islands, Sumenep, Disperindag and local cooperative activities such as application of digital printing techniques, the design theme oflocal wisdom Madura images with coloror multi color mono color and entrepreneurship training and business management. IBM activity was done in the form of training, coaching and mentoring the youth group field of screen printing and printing for souvenirs and handicrafts which aims to: 1 increase the motivation of entrepreneurial partners; 2 improve the understanding of partner business planning and business management; 3 improve human resource capabilities in the production and marketing techniques; 4 develop a network to support youth entrepreneurship development of the creative economy. Youth empowerment group is expected to produce a model that can be used as a model youth entrepreneurial development youth empowerment-based society.Keywords: training, coaching, mentoring, printingandscreen printing, digital printing

Materialising digital collecting: An extended view of digital materiality

OpenAIRE

Mardon, Rebecca; Belk, Russell

2018-01-01

If digital objects are abundant and ubiquitous, why should consumers pay for, much less collect them? The qualities of digital code present numerous challenges for collecting, yet digital collecting can and does occur. We explore the role of companies in constructing digital consumption objects that encourage and support collecting behaviours, identifying material configuration techniques that materialise these objects as elusive and authentic. Such techniques, we argue, may facilitate those ...

Digital Natives: Creating Emergent Exhibitions through Digital Technologies

DEFF Research Database (Denmark)

Smith, Rachel Charlotte; Iversen, Ole Sejer; Dindler, Christian

2011-01-01

. In this way, digital technology can contribute to the creation of emergent exhibitions in which the exhibition is created in dialogue between audiences and the museum. We present experiences from a current research project, the Digital Natives exhibition, in which digital technology was designed......Digital Technology can support the creation of dialogical spaces in the museum, both playful and reflective, that allow audiences to engage in the ongoing construction and reproduction of cultural heritage creating novel connections between self and others and between past, present and future...... as an integral part of the exhibition to encourage dialogue between audiences and the exhibition materials and thereby investigate how the exhibition emerge as a result of this dialogic co-construction inside the exhibition space. In short, the opportunities offered by digital technologies prompts us to consider...

21 CFR 582.4521 - Monosodium phosphate derivatives of mono- and diglycerides of edible fats or oils, or edible fat...

Science.gov (United States)

2010-04-01

... diglycerides of edible fats or oils, or edible fat-forming fatty acids. 582.4521 Section 582.4521 Food and... Monosodium phosphate derivatives of mono- and diglycerides of edible fats or oils, or edible fat-forming... oils, or edible fat-forming fatty acids. (b) Conditions of use. This substance is generally recognized...

Enabling Digital Literacy

DEFF Research Database (Denmark)

Ryberg, Thomas; Georgsen, Marianne

2010-01-01

There are some tensions between high-level policy definitions of “digital literacy” and actual teaching practice. We need to find workable definitions of digital literacy; obtain a better understanding of what digital literacy might look like in practice; and identify pedagogical approaches, which...... support teachers in designing digital literacy learning. We suggest that frameworks such as Problem Based Learning (PBL) are approaches that enable digital literacy learning because they provide good settings for engaging with digital literacy. We illustrate this through analysis of a case. Furthermore......, these operate on a meso-level mediating between high-level concepts of digital literacy and classroom practice....

Stochastic resonance in a time-delayed mono-stable system with correlated multiplicative and additive white noise

International Nuclear Information System (INIS)

Zhou Yu-Rong

2011-01-01

This paper considers the stochastic resonance for a time-delayed mono-stable system, driven by correlated multiplicative and additive white noise. It finds that the output signal-to-noise ratio (SNR) varies non-monotonically with the delayed times. The SNR varies non-monotonically with the increase of the intensities of the multiplicative and additive noise, with the increase of the correlation strength between the two noises, as well as with the system parameter. (general)

Digital Preservation in Open-Source Digital Library Software

Science.gov (United States)

Madalli, Devika P.; Barve, Sunita; Amin, Saiful

2012-01-01

Digital archives and digital library projects are being initiated all over the world for materials of different formats and domains. To organize, store, and retrieve digital content, many libraries as well as archiving centers are using either proprietary or open-source software. While it is accepted that print media can survive for centuries with…

Efeitos de misturas de napropamide e simazine no controle de mono e dicotiledoneas em cafeeiros novos Effects of napropamide and simazine mixtures on the control of mono and dicotyledon on new coffee trees

Directory of Open Access Journals (Sweden)

L.S.P. Cruz

1980-12-01

Full Text Available Com a finalidade de se conhecer a ação de misturas de napropamide e simazine no controle de plantas daninhas mono e dicotiledôneas em cafee iros com dois anos de idade, foi conduzido um experimento de campo em Araras, SP, em 1979/80. 0 delineamento foi o de blocos ao acaso com nove tratamentos e quatro repetições. Os tratamentos foram os seguintes: napropamide a 2,00 kg e 3,00 kg/ha; simazine a 0,50 kg e 0,75 kg/ha; e, misturas de 2,00 kg/ha de napropamide com 0,50 kg e 0,75 kg/ha de simazine, e de 3,00 kg/ha de napropamide também com 0,50 kg e 0,75 kg/ha de simaz ine . Constou do experimento ainda, uma testemunha sem herbicida. Aos 45 dias após a aplicação dos herbicidas foi feita uma contagem das plantas daninhas, e a cada 15 dias, até aos 90 dias da aplicação, foram realizadas observações visuais de porcentagem de infestação do mato. Nestas mesmas épocas também foram realizadas observações sobre sintomas de fi totoxicidade causados pelos herbicidas aos cafeeiros. As plantas daninhas presentes em maior número no ensaio foram as monocotiledôneas capim - de-colchão - Digitaria horizontalis Willd e capimpé -de-galinha Eleusine indica (L.1 Gaertn, e as dicotiledôneas carurú-de-mancha - Amaranthus viridis L. e picão-preto - Bidens pilosa L. Como era esperado, as misturas foram superiores aos tratamentos com herbicidas isolados. sendo bastante eficientes no controle das mono e dicotiledõneas que incidiram no experimento. Todos os tratamentos com 0.75 k ' ha de simazine apresentaram leves sintomas de fitotoxicidade, limitados a algumas folhas dos cafeeiros. até a última observação realizada.A field experiment was conducted in Araras in 1979/80 with the purpose to study the effects of mixture of napropamide and simazine on the control of mono and dicotyledons weeds in two years old coffee trees. The experiment was in randomised blocks with nine treatments and four repplications. The treatments were the following

Digital Density as the Driving Force of Digital Transformation Processes

OpenAIRE

Bush, Xavier

2016-01-01

Digital technologies have increased the influence of technology in business, even changing business models and strategies of organisations. This influence, called Digital Transformation of Business (DT), happens when there is an increase of the number of digital connections, information and interactions. This phenom-ena has been defined as Digital Density (DD) and aims to provide an assessment of the digitalization status of an organization. With the concept of DD we pro-pose the DD Framework, t...

Digital Tectonics

DEFF Research Database (Denmark)

Christiansen, Karl; Borup, Ruben; Søndergaard, Asbjørn

2014-01-01

Digital Tectonics treats the architectonical possibilities in digital generation of form and production. The publication is the first volume of a series, in which aspects of the strategic focus areas of the Aarhus School of Architecture will be disseminated.......Digital Tectonics treats the architectonical possibilities in digital generation of form and production. The publication is the first volume of a series, in which aspects of the strategic focus areas of the Aarhus School of Architecture will be disseminated....

Digital Literacy Learning in Higher Education through Digital Storytelling Approach

Science.gov (United States)

Chan, Banny S. K.; Churchill, Daniel; Chiu, Thomas K. F.

2017-01-01

It is necessary to develop digital literacy skills with which students can communicate and express their ideas effectively using digital media. The educational sectors around the world are beginning to incorporate digital literacy into the curriculum. Digital storytelling, one of the possible classroom activities, is an approach which may help…

Digital mammography

International Nuclear Information System (INIS)

Bick, Ulrich; Diekmann, Felix

2010-01-01

This state-of-the-art reference book provides in-depth coverage of all aspects of digital mammography, including detector technology, image processing, computer-aided diagnosis, soft-copy reading, digital workflow, and PACS. Specific advantages and disadvantages of digital mammography in comparison to screen-film mammography are thoroughly discussed. By including authors from both North America and Europe, the book is able to outline variations in the use, acceptance, and quality assurance of digital mammography between the different countries and screening programs. Advanced imaging techniques and future developments such as contrast mammography and digital breast tomosynthesis are also covered in detail. All of the chapters are written by internationally recognized experts and contain numerous high-quality illustrations. This book will be of great interest both to clinicians who already use or are transitioning to digital mammography and to basic scientists working in the field. (orig.)

Cost Model for Digital Preservation: Cost of Digital Migration

DEFF Research Database (Denmark)

Kejser, Ulla Bøgvad; Nielsen, Anders Bo; Thirifays, Alex

2011-01-01

The Danish Ministry of Culture has funded a project to set up a model for costing preservation of digital materials held by national cultural heritage institutions. The overall objective of the project was to increase cost effectiveness of digital preservation activities and to provide a basis...... for comparing and estimating future cost requirements for digital preservation. In this study we describe an activity-based costing methodology for digital preservation based on the Open Archice Information System (OAIS) Reference Model. Within this framework, which we denote the Cost Model for Digital...... Preservation (CMDP), the focus is on costing the functional entity Preservation Planning from the OAIS and digital migration activities. In order to estimate these costs we have identified cost-critical activities by analysing the functions in the OAIS model and the flows between them. The analysis has been...

Digital Tourism on the Way to Digital Marketing Success

OpenAIRE

RATIU, Monica Paula; PURCAREA, Ioan Matei

2015-01-01

There is a real need of digital support of the tourist experience before, during and after the tourist activity, because digitization is steadily becoming the main pathway for consumer journeys. The digital revolution changed the way consumers shop for travel products and interact with brands. Tourism businesses need to utilize digital marketing techniques in their practices and to right track consumer activity across channels and devices. Getting vital information from customers via social m...

Digital Library and Digital Reference Service: Integration and Mutual Complementarity

Science.gov (United States)

Liu, Jia

2008-01-01

Both the digital library and the digital reference service were invented and have been developed under the networked environment. Among their intersections, the fundamental thing is their symbiotic interest--serving the user in a more efficient way. The article starts by discussing the digital library and its service and the digital reference…

Digital Materialisms: Frameworks for Digital Media Studies

OpenAIRE

Casemajor, Nathalie

2015-01-01

Since the 1980s, digital materialism has received increasing interest in the field of media studies. Materialism as a theoretical paradigm assumes that all things in the world are tied to physical processes and matter. Yet within digital media studies, the understanding of what should be the core object of a materialist analysis is debated. This paper proposes to untangle some of the principal theoretical propositions that compose the field of digital materialism. It outlines six frameworks t...

Hydrolysis of Zr(4) with formation of mono- and polynuclear hydroxocomplexes in solutions

International Nuclear Information System (INIS)

Davydov, Yu.P.; Zabrodskij, V.N.

1987-01-01

The state of Zr(4) has been studied in the wide range of H + -ions concentrations (10 -3 -3.0 mol/l) and in the wide range of Zr(4) concentrations (10 -13 -10 -12 mol/l) in the solution using a set of such physical-chemical methods as spectrophotometry, ion exchange, dialysis, centrifugation. The conditions of formation of hydrated cations, monochange, dialysis, centrifugation. The conditions of formation of hydrated cations, mono- and polynuclear hydrocomplexes, colloidal-size particles have been determined. The thermodynamic stability of ZrOH 3+ and Zr(OH) 2 2+ complexes has been determined by the ion exchange and spectrophotometry methods

Digital Banking: Risks of Financial Digitalization

Directory of Open Access Journals (Sweden)

Kornіvska Valerіa O.

2017-09-01

Full Text Available The paper demonstrates the results of the research into development of the digital economy in the global financial space, shows the contradictions of these processes in the context of the growth of financial inclusion of households, identifies the risks of active introduction of digital banking in poor countries of the world. The characteristics of the processes of growth of the influence of banking institutions on the operational activity and daily life of households are given, and it is proved that under conditions of digital banking, without having any other alternative ways of economic activity in terms of money circulation than non-cash turnover, clients are forced to agree to unlimited presence of financial operators in social systems. It is substantiated that in Ukraine the global risk of digitalization of the society is gradually developing as a result of the creation of unified information systems for the control of global financial flows.

Older people and digital disengagement: a fourth digital divide?

Science.gov (United States)

Olphert, Wendy; Damodaran, Leela

2013-01-01

Digital technologies are becoming more pervasive in all areas of society. Enabling everyone to have access and capability to use the Internet and associated digital technologies, summed up in the term 'digital inclusion', is seen to have wide-ranging benefits to the individual, to the economy and to society. For older people, being digitally included can help them to maintain their independence, social connectedness and sense of worth in the face of declining health or limited capabilities, as well as also offering new opportunities to improve their quality of life. At present however, access to the technology and to the benefits is not equally distributed either between or within nations, and older people tend to be on the 'wrong' side of what is termed the 'digital divide'. Governments globally are developing strategies to promote digital inclusion and indeed Internet uptake is increasing steadily, including amongst older people. However, such strategies have focussed on getting people online, and there appears to be an assumption that once someone is online they will remain 'digitally engaged'. In fact statistics show that some users give up using the Internet, and there is emerging evidence that older people are more vulnerable to the factors which can lead to this outcome. The authors see this phenomenon as a potential but largely unrecognised 'fourth digital divide' which has serious implications for social inclusion. The objectives of this article are (a) to raise awareness of the phenomenon of digital disengagement by considering some of the emerging evidence, (b) to explore some of the potential implications of not recognising and therefore not addressing the needs of the digitally disengaged older population, and (c) to reveal the prevailing gap in knowledge which future research should address. Copyright © 2013 S. Karger AG, Basel.

Sports Digitalization

DEFF Research Database (Denmark)

Xiao, Xiao; Hedman, Jonas; Tan, Felix Ter Chian

2017-01-01

evolution, as digital technologies are increasingly entrenched in a wide range of sporting activities and for applications beyond mere performance enhancement. Despite such trends, research on sports digitalization in the IS discipline is surprisingly still nascent. This paper aims at establishing...... a discourse on sports digitalization within the discipline. Toward this, we first provide an understanding of the institutional characteristics of the sports industry, establishing its theoretical importance and relevance in our discipline; second, we reveal the latest trends of digitalization in the sports...

Digitized mammograms

International Nuclear Information System (INIS)

Bruneton, J.N.; Balu-Maestro, C.; Rogopoulos, A.; Chauvel, C.; Geoffray, A.

1988-01-01

Two observers conducted a blind evaluation of 100 mammography files, including 47 malignant cases. Films were read both before and after image digitization at 50 μm and 100 μm with the FilmDRSII. Digitization permitted better analysis of the normal anatomic structures and moderately improved diagnostic sensitivity. Searches for microcalcifications before and after digitization at 100 μm and 50 μm showed better analysis of anatomic structures after digitization (especially for solitary microcalcifications). The diagnostic benefit, with discovery of clustered microcalcifications, was more limited (one case at 100 μm, nine cases at 50 μm). Recognition of microcalcifications was clearly improved in dense breasts, which can benefit from reinterpretation after digitization at 50 μm rather 100μm

Digital radiography

International Nuclear Information System (INIS)

Coulomb, M.; Dal Soglio, S.; Pittet-Barbier, L.; Ranchoup, Y.; Thony, F.; Ferretti, G.; Robert, F.

1992-01-01

Digital projection radiography may replace conventional radiography some day, provided it can meet several requirements: equal or better diagnostic effectiveness of the screen-film systems; reasonable image cost; real improvement in the productivity of the Departments of Imaging. All digital radiographic systems include an X-ray source, an image acquisition and formatting sub-system, a display and manipulation sub-system, and archiving subsystem and a laser editing system, preferably shared by other sources of digital images. Three digitization processes are available: digitization of the radiographic film, digital fluorography and phospholuminescent detectors with memory. The advantages of digital fluoroscopy are appealing: real-time image acquisition, suppression of cassettes; but its disadvantages are far from negligible: it cannot be applied to bedside radiography, the field of examination is limited, and the wide-field spatial resolution is poor. Phospholuminescent detectors with memory have great advantages: they can be used for bedside radiographs and on all the common radiographic systems; spatial resolution is satisfactory; its current disadvantages are considerable. These two systems, have common properties making up the entire philosophy of digital radiology and specific features that must guide our choice according to the application. Digital fluorography is best applied in pediatric radiology. However, evaluation works have showed that it was applicable with sufficient quality to many indications of general radiology in which a fluoroscopic control and fast acquisition of the images are essential; the time gained on the examination may be considerable, as well as the savings on film. Detectors with memory are required for bedside radiographs, in osteoarticular and thoracic radiology, in all cases of traumatic emergency and in the resuscitation and intensive care departments

Transplacental transfer of monomethyl phthalate and mono(2-ethylhexyl) phthalate in a human placenta perfusion system

DEFF Research Database (Denmark)

Mose, Tina; Knudsen, Lisbeth E; Hedegaard, Morten

2007-01-01

The transplacental passage of monomethylphtalate (mMP) and mono (2-ethylhexyl) phthalate (mEHP) was studied using an ex vivo placental perfusion model with simultaneous perfusion of fetal and maternal circulation in a single cotyledon. Umbilical cord blood and placental tissue collected both before...... plasma samples. mMP and possibly other short-chained phthalate monoesters in maternal blood can cross the placenta by slow transfer, whereas the results indicate no placental transfer of mEHP. Further studies are recommended....

Digital Sensor Technology

Energy Technology Data Exchange (ETDEWEB)

Ted Quinn; Jerry Mauck; Richard Bockhorst; Ken Thomas

2013-07-01

The nuclear industry has been slow to incorporate digital sensor technology into nuclear plant designs due to concerns with digital qualification issues. However, the benefits of digital sensor technology for nuclear plant instrumentation are substantial in terms of accuracy, reliability, availability, and maintainability. This report demonstrates these benefits in direct comparisons of digital and analog sensor applications. It also addresses the qualification issues that must be addressed in the application of digital sensor technology.

Metallic Contact Formation for Molecular Electronics : Interactions between Vapor-Deposited Metals and Self-Assembled Monolayers of Conjugated Mono- and Dithiols

NARCIS (Netherlands)

Boer, Bert de; Frank, Martin M.; Chabal, Yves J.; Jiang, Weirong; Garfunkel, Eric; Bao, Zhenan

2004-01-01

We present grazing-incidence Fourier transform infrared and AFM data of Au, Al, and Ti vapor-deposited onto self-assembled monolayers (SAMs) of conjugated mono- and dithiols. SAMs of 4,4'''-dimercapto-p-quaterphenyl, 4,4''-dimercapto-p-terphenyl, and 4,4'-dimercapto-p-biphenyl have reactive thiols

Transient heating and evaporation of moving mono-component liquid fuel droplets

DEFF Research Database (Denmark)

Yin, Chungen

2016-01-01

of which the flow and energy transport equations are numerically solved using the finite volume method. The computer code for the model is developed in a generic 3D framework and verified in different ways (e.g., by comparison against analytical solutions for simplified cases, and against experimental......This paper presents a complete description of a model for transient heating and evaporation of moving mono-component liquid fuel droplets. The model mainly consists of gas phase heat and mass transfer analysis, liquid phase analysis, and droplet dynamics analysis, which address the interaction...... between the moving droplets and free-stream flow, the flow and heat and mass transfer within the droplets, and the droplet dynamics and size, respectively. For the liquid phase analysis, the droplets are discretized into a number of control volumes along the radial, polar and azimuthal directions, on each...

Digital Sensor Technology

Energy Technology Data Exchange (ETDEWEB)

Thomas, Ken D. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Quinn, Edward L. [Technology Resources, Dana Point, CA (United States); Mauck, Jerry L. [Technology Resources, Dana Point, CA (United States); Bockhorst, Richard M. [Technology Resources, Dana Point, CA (United States)

2015-02-01

The nuclear industry has been slow to incorporate digital sensor technology into nuclear plant designs due to concerns with digital qualification issues. However, the benefits of digital sensor technology for nuclear plant instrumentation are substantial in terms of accuracy and reliability. This paper, which refers to a final report issued in 2013, demonstrates these benefits in direct comparisons of digital and analog sensor applications. Improved accuracy results from the superior operating characteristics of digital sensors. These include improvements in sensor accuracy and drift and other related parameters which reduce total loop uncertainty and thereby increase safety and operating margins. An example instrument loop uncertainty calculation for a pressure sensor application is presented to illustrate these improvements. This is a side-by-side comparison of the instrument loop uncertainty for both an analog and a digital sensor in the same pressure measurement application. Similarly, improved sensor reliability is illustrated with a sample calculation for determining the probability of failure on demand, an industry standard reliability measure. This looks at equivalent analog and digital temperature sensors to draw the comparison. The results confirm substantial reliability improvement with the digital sensor, due in large part to ability to continuously monitor the health of a digital sensor such that problems can be immediately identified and corrected. This greatly reduces the likelihood of a latent failure condition of the sensor at the time of a design basis event. Notwithstanding the benefits of digital sensors, there are certain qualification issues that are inherent with digital technology and these are described in the report. One major qualification impediment for digital sensor implementation is software common cause failure (SCCF).

Digital work in a digitally challenged organization

NARCIS (Netherlands)

Davison, R.M.; Ou, Carol

Digitally literate employees are accustomed to having free access to digital media technologies. However, some organizations enact information technology (IT) governance structures that explicitly proscribe access to these technologies, resulting in considerable tension between employees and the

Searches for Dark Matter via Mono-W Production in Inert Doublet Model at the LHC

Science.gov (United States)

Wan, Neng; Li, Niu; Zhang, Bo; Yang, Huan; Zhao, Min-Fu; Song, Mao; Li, Gang; Guo, Jian-You

2018-05-01

The Inert Doublet Model (IDM) is one of the many beyond Standard Model scenarios with an extended scalar sector, which provide a suitable dark matter particle candidate. Dark matter associated visible particle production at high energy colliders provides a unique way to determine the microscopic properties of the dark matter particle. In this paper, we investigate that the mono-W + missing transverse energy production at the Large Hadron Collider (LHC), where W boson decay to a lepton and a neutrino. We perform the analysis for the signal of mono-W production in the IDM and the Standard Model (SM) backgrounds, and the optimized criteria employing suitable cuts are chosen in kinematic variables to maximize signal significance. We also investigate the discovery potential in several benchmark scenarios at the 14 TeV LHC. When the light Z2 odd scalar higgs of mass is about 65 GeV, charged Higgs is in the mass range from 120 GeV to 250 GeV, it provides the best possibility with a signal significance of about 3σ at an integrated luminosity of about 3000 fb‑1. Supported by the National Natural Science Foundation of China under Grant Nos. 11205003, 11305001, 11575002, the Key Research Foundation of Education Ministry of Anhui Province of China under Grant Nos. KJ2017A032, KJ2016A749, KJ2013A260, and Natural Science Foundation of West Anhui University under Grant No. WXZR201614

Exploring digital professionalism.

Science.gov (United States)

Ellaway, Rachel H; Coral, Janet; Topps, David; Topps, Maureen

2015-01-01

The widespread use of digital media (both computing devices and the services they access) has blurred the boundaries between our personal and professional lives. Contemporary students are the last to remember a time before the widespread use of the Internet and they will be the first to practice in a largely e-health environment. This article explores concepts of digital professionalism and their place in contemporary medical education, and proposes a series of principles of digital professionalism to guide teaching, learning and practice in the healthcare professions. Despite the many risks and fears surrounding their use, digital media are not an intrinsic threat to medical professionalism. Professionals should maintain the capacity for deliberate, ethical, and accountable practice when using digital media. The authors describe a digital professionalism framework structured around concepts of proficiency, reputation, and responsibility. Digital professionalism can be integrated into medical education using strategies based on awareness, alignment, assessment, and accountability. These principles of digital professionalism provide a way for medical students and medical practitioners to embrace the positive aspects of digital media use while being mindful and deliberate in its use to avoid or minimize any negative consequences.

Date of planting and seeding rate effects on quantitative and qualitative characteristics of turnip in agro forestry compared to mono cropping systems

Directory of Open Access Journals (Sweden)

M.R. Chaichi

2016-05-01

Full Text Available Agroforestry is one the aspects of sustainable agriculture in which multiple cropping of perennial trees in mixture with crops guarantees the environmental, economical and social sustainability in rural communities. High demands for forage in Northern provinces of Iran lead to agroforestry in citrus orchards as a potential mean for forage production through agroforestry systems. This research was conducted to determine the best planting date and seeding rate of turnip in agroforestry and mono cropping systems. The treatments were arranged as split factorial based on a completely randomized block design with three replications. The cropping systems (agroforestry and mono cropping were assigned to the main plots and the factorial combinations of planting dates (March 10th, March 25th, and April 9th and seeding rates (1, 2, and 4 kg seed ha-1 were randomly assigned to the subplots. The results of the experiment showed that as the seeding rate increased to 4 kg.ha-1, a significant increase (by 5% in total forage production was observed in both cropping systems. A decreasing trend in forage production was observed in latter planting dates for both cropping systems; however, this decrement in mono cropping was more severe than agroforestry system. In later planting dates the water soluble carbohydrates and forage dry matter digestibility increased but ADF decreased. The results of this experiment indicated a great potential for forage production in citrus orchards of the northern provinces of the country through agroforestry systems.

Digital multilayer tomography

International Nuclear Information System (INIS)

Dueber, C.; Klose, K.J.; Thelen, M.

1991-01-01

With digital multilayer tomography a sequence of projection images is recorded by an image intensifier television system and stored as digital data during a linear run of a layer sequence. Using this data record, tomograms of the examined body region can be computed for any layer thickness by shifts and superimposition of the single projections later at a digital workstation. The qualities of digital and conventional tomograms are basically comparable. A drawback of digital tomography is its lower local resolution (512 x 512 image matrix), advantages are a lower radiation exposure, a shorter patient examination time, and the facilities of digital image processing (later processing, archive setup, transmission). (orig.) [de

Digital Citizenship

Science.gov (United States)

Isman, Aytekin; Canan Gungoren, Ozlem

2014-01-01

Era in which we live is known and referred as digital age.In this age technology is rapidly changed and developed. In light of these technological advances in 21st century, schools have the responsibility of training "digital citizen" as well as a good citizen. Digital citizens must have extensive skills, knowledge, Internet and …

Electron transfer kinetics on mono- and multilayer graphene.

Science.gov (United States)

Velický, Matěj; Bradley, Dan F; Cooper, Adam J; Hill, Ernie W; Kinloch, Ian A; Mishchenko, Artem; Novoselov, Konstantin S; Patten, Hollie V; Toth, Peter S; Valota, Anna T; Worrall, Stephen D; Dryfe, Robert A W

2014-10-28

Understanding of the electrochemical properties of graphene, especially the electron transfer kinetics of a redox reaction between the graphene surface and a molecule, in comparison to graphite or other carbon-based materials, is essential for its potential in energy conversion and storage to be realized. Here we use voltammetric determination of the electron transfer rate for three redox mediators, ferricyanide, hexaammineruthenium, and hexachloroiridate (Fe(CN)(6)(3-), Ru(NH3)(6)(3+), and IrCl(6)(2-), respectively), to measure the reactivity of graphene samples prepared by mechanical exfoliation of natural graphite. Electron transfer rates are measured for varied number of graphene layers (1 to ca. 1000 layers) using microscopic droplets. The basal planes of mono- and multilayer graphene, supported on an insulating Si/SiO(2) substrate, exhibit significant electron transfer activity and changes in kinetics are observed for all three mediators. No significant trend in kinetics with flake thickness is discernible for each mediator; however, a large variation in kinetics is observed across the basal plane of the same flakes, indicating that local surface conditions affect the electrochemical performance. This is confirmed by in situ graphite exfoliation, which reveals significant deterioration of initially, near-reversible kinetics for Ru(NH3)(6)(3+) when comparing the atmosphere-aged and freshly exfoliated graphite surfaces.

Activity-based assay for human mono-ADP-ribosyltransferases ARTD7/PARP15 and ARTD10/PARP10 aimed at screening and profiling inhibitors.

Science.gov (United States)

Venkannagari, Harikanth; Fallarero, Adyary; Feijs, Karla L H; Lüscher, Bernhard; Lehtiö, Lari

2013-05-13

Poly(ADP-ribose) polymerases (PARPs) or diphtheria toxin like ADP-ribosyl transferases (ARTDs) are enzymes that catalyze the covalent modification of proteins by attachment of ADP-ribose units to the target amino acid residues or to the growing chain of ADP-ribose. A subclass of the ARTD superfamily consists of mono-ADP-ribosyl transferases that are thought to modify themselves and other substrate proteins by covalently adding only a single ADP-ribose moiety to the target. Many of the ARTD enzymes are either established or potential drug targets and a functional activity assay for them will be a valuable tool to identify selective inhibitors for each enzyme. Existing assays are not directly applicable for screening of inhibitors due to the different nature of the reaction and different target molecules. We modified and applied a fluorescence-based assay previously described for PARP1/ARTD1 and tankyrase/ARTD5 for screening of PARP10/ARTD10 and PARP15/ARTD7 inhibitors. The assay measures the amount of NAD(+) present after chemically converting it to a fluorescent analog. We demonstrate that by using an excess of a recombinant acceptor protein the performance of the activity-based assay is excellent for screening of compound libraries. The assay is homogenous and cost effective, making it possible to test relatively large compound libraries. This method can be used to screen inhibitors of mono-ARTDs and profile inhibitors of the enzyme class. The assay was optimized for ARTD10 and ARTD7, but it can be directly applied to other mono-ARTDs of the ARTD superfamily. Profiling of known ARTD inhibitors against ARTD10 and ARTD7 in a validatory screening identified the best inhibitors with submicromolar potencies. Only few of the tested ARTD inhibitors were potent, implicating that there is a need to screen new compound scaffolds. This is needed to create small molecules that could serve as biological probes and potential starting points for drug discovery projects against

Comparison of dimensionality reduction techniques for the fault diagnosis of mono block centrifugal pump using vibration signals

Directory of Open Access Journals (Sweden)

N.R. Sakthivel

2014-03-01

Full Text Available Bearing fault, Impeller fault, seal fault and cavitation are the main causes of breakdown in a mono block centrifugal pump and hence, the detection and diagnosis of these mechanical faults in a mono block centrifugal pump is very crucial for its reliable operation. Based on a continuous acquisition of signals with a data acquisition system, it is possible to classify the faults. This is achieved by the extraction of features from the measured data and employing data mining approaches to explore the structural information hidden in the signals acquired. In the present study, statistical features derived from the vibration data are used as the features. In order to increase the robustness of the classifier and to reduce the data processing load, dimensionality reduction is necessary. In this paper dimensionality reduction is performed using traditional dimensionality reduction techniques and nonlinear dimensionality reduction techniques. The effectiveness of each dimensionality reduction technique is also verified using visual analysis. The reduced feature set is then classified using a decision tree. The results obtained are compared with those generated by classifiers such as Naïve Bayes, Bayes Net and kNN. The effort is to bring out the better dimensionality reduction technique–classifier combination.

Digital image analysis of X-ray television with an image digitizer

International Nuclear Information System (INIS)

Mochizuki, Yasuo; Akaike, Hisahiko; Ogawa, Hitoshi; Kyuma, Yukishige

1995-01-01

When video signals of X-ray fluoroscopy were transformed from analog-to-digital ones with an image digitizer, their digital characteristic curves, pre-sampling MTF's and digital Wiener spectral could be measured. This method was advant ageous in that it was able to carry out data sampling because the pixel values inputted could be verified on a CRT. The system of image analysis by this method is inexpensive and effective in evaluating the image quality of digital system. Also, it is expected that this method can be used as a tool for learning the measurement techniques and physical characteristics of digital image quality effectively. (author)

Digital Native and Digital Immigrant Use of Scholarly Network for Doctoral Learners

Directory of Open Access Journals (Sweden)

Ronald Berman

2014-01-01

Full Text Available The Doctoral Community Network (DC is a learner driven, scholarly community designed to help online doctoral learners successfully complete their dissertation and program of study. While digital natives grew up in an environment immersed in technology, digital immigrants adapted to this environment through their ability to learn and adjust to new technologies. With several thousand Doctoral Community Network users, it was not known to what extent digital immigrants had embraced the technology. A study of 988 users determined that digital immigrants used the Doctoral Community Network more often and for a larger variety of purposes than digital natives did. Specifically, digital immigrants log-on more frequently, view leadership content at higher rates, read more blogs, use more doctoral community network research resources, and send and receive more peer messages than digital natives do. This research supports existing literature that found that digital immigrants possess higher levels of social reliance than digital natives while contradicting other literature that found that digital natives tend to use the internet for social networking and blog diaries at higher rates.

Digital displacements

DEFF Research Database (Denmark)

Pors, Anja Svejgaard

2014-01-01

In recent years digital reforms are being introduced in the municipal landscape of Denmark. The reforms address the interaction between citizen and local authority. The aim is, that by 2015 at least 80 per cent of all correspondence between citizens and public authority will be transmitted through...... digital interface. However, the transformation of citizen services from traditional face-to-face interaction to digital self-service gives rise to new practices; some citizens need support to be able to manage self-service through digital tools. A mixture of support and teaching, named co......-service, is a new task in public administration, where street level bureaucrats assist citizens in using the new digital solutions. The paper is based on a case study conducted primarily in a citizen service centre in Copenhagen, Denmark. Based on ethnography the paper gives an empirical account of the ongoing...

The Effects of Activities for Digital Citizenship on Students’ Attitudes toward Digital Citizenship and Their Reflections on Students’ Understanding about Digital Citizenship

Directory of Open Access Journals (Sweden)

Hıdır KARADUMAN

2014-05-01

Full Text Available Advances in info-communication technologies have brought many social, cultural, and economic changes along across the world. Recent reflections of these changes over citizenship studies are noteworthy. One of the relevant concepts, digital citizenship can be defined as applying and advocating behaviors necessary for legal, ethical, safe, and responsible use of info-communication technologies in online settings (ISTE, 2007. Day by day, individuals are becoming more and more digital citizens with the spread of the Internet and digital communication devices. However, this gives rise to discussions about problems related with ethics, privacy and security, health, communication, and etc. (Symantec, 2010; Deniz, 2010; Kadll, Kumba & Kanamad, 2010; Gunduz & Ozdinc, 2008; Kabakci & Can, 2009. All these hot issues, debates, and current technological competence standards point that teachers should teach this concept to their students as efficiently as possible by adopting digital citizenship (Greenhow, 2010. Ribble (2006 states that this education can be carried out through 9 dimensions such as digital ethics, digital communication, digital literacy, digital access, digital commerce, digital rights and law, digital privacy and security, digital responsibility, and digital health & wellness.

Simulation study of accelerator based quasi-mono-energetic epithermal neutron beams for BNCT.

Science.gov (United States)

Adib, M; Habib, N; Bashter, I I; El-Mesiry, M S; Mansy, M S

2016-01-01

Filtered neutron techniques were applied to produce quasi-mono-energetic neutron beams in the energy range of 1.5-7.5 keV at the accelerator port using the generated neutron spectrum from a Li (p, n) Be reaction. A simulation study was performed to characterize the filter components and transmitted beam lines. The feature of the filtered beams is detailed in terms of optimal thickness of the primary and additive components. A computer code named "QMNB-AS" was developed to carry out the required calculations. The filtered neutron beams had high purity and intensity with low contamination from the accompanying thermal, fast neutrons and γ-rays. Copyright © 2015 Elsevier Ltd. All rights reserved.

Digital Level Layers for Digital Curve Decomposition and Vectorization

Directory of Open Access Journals (Sweden)

Laurent Provot

2014-07-01

Full Text Available The purpose of this paper is to present Digital Level Layers and show the motivations for working with such analytical primitives in the framework of Digital Geometry. We first compare their properties to morphological and topological counterparts, and then we explain how to recognize them and use them to decompose or vectorize digital curves and contours.

Baseline Screening Mammography: Performance of Full-Field Digital Mammography Versus Digital Breast Tomosynthesis.

Science.gov (United States)

McDonald, Elizabeth S; McCarthy, Anne Marie; Akhtar, Amana L; Synnestvedt, Marie B; Schnall, Mitchell; Conant, Emily F

2015-11-01

Baseline mammography studies have significantly higher recall rates than mammography studies with available comparison examinations. Digital breast tomosynthesis reduces recalls when compared with digital mammographic screening alone, but many sites operate in a hybrid environment. To maximize the effect of screening digital breast tomosynthesis with limited resources, choosing which patient populations will benefit most is critical. This study evaluates digital breast tomosynthesis in the baseline screening population. Outcomes were compared for 10,728 women who underwent digital mammography screening, including 1204 (11.2%) baseline studies, and 15,571 women who underwent digital breast tomosynthesis screening, including 1859 (11.9%) baseline studies. Recall rates, cancer detection rates, and positive predictive values were calculated. Logistic regression estimated the odds ratios of recall for digital mammography versus digital breast tomosynthesis for patients undergoing baseline screening and previously screened patients, adjusted for age, race, and breast density. In the baseline subgroup, recall rates for digital mammography and digital breast tomosynthesis screening were 20.5% and 16.0%, respectively (p = 0.002); digital breast tomosynthesis screening in the baseline subgroup resulted in a 22% reduction in recall compared with digital mammography, or 45 fewer patients recalled per 1000 patients screened. Digital breast tomosynthesis screening in the previously screened patients resulted in recall reduction of 14.3% (p tomosynthesis than from digital mammography alone.

Pedagogical Comparison of Five Reactions Performed under Microwave Heating in Multi-Mode versus Mono-Mode Ovens: Diels-Alder Cycloaddition, Wittig Salt Formation, E2 Dehydrohalogenation to Form an Alkyne, Williamson Ether Synthesis, and Fischer Esterification

Science.gov (United States)

Baar, Marsha R.; Gammerdinger, William; Leap, Jennifer; Morales, Erin; Shikora, Jonathan; Weber, Michael H.

2014-01-01

Five reactions were rate-accelerated relative to the standard reflux workup in both multi-mode and mono-mode microwave ovens, and the results were compared to determine whether the sequential processing of a mono-mode unit could provide for better lab logistics and pedagogy. Conditions were optimized so that yields matched in both types of…

Comparing environmental consequences of anaerobic mono- and co-digestion of pig manure to produce bio-energy – A life cycle perspective

NARCIS (Netherlands)

Vries, de J.W.; Vinken, T.M.W.J.; Hamelin, L.; Boer, de I.J.M.

2012-01-01

The aim of this work was to assess the environmental consequences of anaerobic mono- and co-digestion of pig manure to produce bio-energy, from a life cycle perspective. This included assessing environmental impacts and land use change emissions (LUC) required to replace used co-substrates for

Digital building planning - digital construction; Digitale Gebaeudeplanung - digitales Bauen

Energy Technology Data Exchange (ETDEWEB)

Friedrichs, K. [Karlsruhe Univ. (T.H.) (Germany). Fakultaet fuer Architektur

1995-12-31

In chapter 3 of the anthology about building control the following aspects are discussed: digital building planning and digital construction, which are characterised by an increasing complexity of planning, buildings, construction technology and construction processes. In this respect the digital-technical scenarios, passive and active objects as well as digital construction are described. (BWI) [Deutsch] Kapitel 3 des Sammelbandes ueber Building Control ist den Themen Digitale Gebaeudeplanung und Digitales Bauen gewidmet, die durch die zunehmende Komplexitaet von Planung, Gebaeuden, Bautechnologien und -prozessen bedingt sind. In diesem Zusammenhang werden folgende Themen angesprochen: Digitale technische Szenarien, passive und aktive Objekte sowie digitales Bauen. (BWI)

Experimental investigation of heat transfer potential of Al2O3/Water-Mono Ethylene Glycol nanofluids as a car radiator coolant

Directory of Open Access Journals (Sweden)

Dattatraya G. Subhedar

2018-03-01

Full Text Available In this research, the heat transfer potential of Al2O3/Water-Mono Ethylene Glycol nanofluids is investigated experimentally as a coolant for car radiators. The base fluid was the mixture of water and mono ethylene glycol with 50:50 proportions by volume. The stable nanofluids obtained by ultra-sonication are used in all experiments. In this study nanoparticle volume fraction, coolant flow rate, inlet temperature used in the ranges of 0.2–0.8%, 4–9 l per minute and 65–85 °C. The results show that the heat transfer performance of radiator is enhanced by using nanofluids compared to conventional coolant. Nanofluid with lowest 0.2% volume fraction 30% rise in heat transfer is observed. Also the estimation of reduction in frontal area of radiator if base fluid is replaced by Nanofluid is done which will make lighter cooling system, produce less drag and save the fuel cost.

Digital gaming expertise

DEFF Research Database (Denmark)

Toft-Nielsen, Claus

In a digitally saturated environment digital media users of all kinds, engaged in different areas of activity, are increasingly categorized in terms of their ability to appropriate and use digital media – they are regarded as non-users, experts, natives, or literates for instance. Within communic......In a digitally saturated environment digital media users of all kinds, engaged in different areas of activity, are increasingly categorized in terms of their ability to appropriate and use digital media – they are regarded as non-users, experts, natives, or literates for instance. Within...... communication and game studies there are multiple understandings of how digital expertise is expressed and performed, and subsequently how these expressions and performances can be valued, understood and theorized within the research community. Among other things expertise with and within digital games has......-of-game (Schrøder, 2003) in a three-year-long study of men and women (couples and singles) playing the largest Massively Multiplayer Online Role-Playing Game to date, World of Warcraft. In focusing on how different aspects of gaming expertise are articulated, negotiated, and performed, I aim to illustrate how...

Practical digital mammography

Energy Technology Data Exchange (ETDEWEB)

Hashimoto, Beverly E. [Washington Univ., Seattle, WA (United States)]|[Virginia Mason Medical Center, VA (United States)

2008-07-01

This book is meant for the radiologist who is facing the challenge of organizing a digital mammographic imaging center. This text is meant to be a practical book that provides information about digital mammographic physics and equipment which will allow one to intelligently compare technologies and systems. Some of the major challenges include: large expense; rapidly changing technology, and inconsistent connectivity; and finally, need for strong information technology support. The initial conversion cost to digital mammographic imaging is relatively expensive due to the cost of digital mammography hardware, software, and storage. Virtually all other imaging modalities are being converted to purely digital storage and transfer, and the digital trend in mammography is inevitable. Technical advantages of digital mammography are described. However, the improved flexibility in image display and transfer are some of its strongest features. In conclusion, although there are increasing imaging modalities that may be used to evaluate breast disease, mammography will continue to play a key role in detecting breast cancer. To be an effective imager, the radiologist should become familiar with digital mammography and understand its role within the increasing complex structure of breast imaging techniques.

Practical digital mammography

International Nuclear Information System (INIS)

Hashimoto, Beverly E.

2008-01-01

This book is meant for the radiologist who is facing the challenge of organizing a digital mammographic imaging center. This text is meant to be a practical book that provides information about digital mammographic physics and equipment which will allow one to intelligently compare technologies and systems. Some of the major challenges include: large expense; rapidly changing technology, and inconsistent connectivity; and finally, need for strong information technology support. The initial conversion cost to digital mammographic imaging is relatively expensive due to the cost of digital mammography hardware, software, and storage. Virtually all other imaging modalities are being converted to purely digital storage and transfer, and the digital trend in mammography is inevitable. Technical advantages of digital mammography are described. However, the improved flexibility in image display and transfer are some of its strongest features. In conclusion, although there are increasing imaging modalities that may be used to evaluate breast disease, mammography will continue to play a key role in detecting breast cancer. To be an effective imager, the radiologist should become familiar with digital mammography and understand its role within the increasing complex structure of breast imaging techniques

Digitally-Driven Architecture

Directory of Open Access Journals (Sweden)

Henriette Bier

2014-07-01

Full Text Available The shift from mechanical to digital forces architects to reposition themselves: Architects generate digital information, which can be used not only in designing and fabricating building components but also in embedding behaviours into buildings. This implies that, similar to the way that industrial design and fabrication with its concepts of standardisation and serial production influenced modernist architecture, digital design and fabrication influences contemporary architecture. While standardisation focused on processes of rationalisation of form, mass-customisation as a new paradigm that replaces mass-production, addresses non-standard, complex, and flexible designs. Furthermore, knowledge about the designed object can be encoded in digital data pertaining not just to the geometry of a design but also to its physical or other behaviours within an environment. Digitally-driven architecture implies, therefore, not only digitally-designed and fabricated architecture, it also implies architecture – built form – that can be controlled, actuated, and animated by digital means.In this context, this sixth Footprint issue examines the influence of digital means as pragmatic and conceptual instruments for actuating architecture. The focus is not so much on computer-based systems for the development of architectural designs, but on architecture incorporating digital control, sens­ing, actuating, or other mechanisms that enable buildings to inter­act with their users and surroundings in real time in the real world through physical or sensory change and variation.

Topographic Digital Raster Graphics - USGS DIGITAL RASTER GRAPHICS

Data.gov (United States)

NSGIC Local Govt | GIS Inventory — USGS Topographic Digital Raster Graphics downloaded from LABINS (http://data.labins.org/2003/MappingData/drg/drg_stpl83.cfm). A digital raster graphic (DRG) is a...

Nigeria’s Mono-Cultural Economy: Impact Assessment and Prospects

Directory of Open Access Journals (Sweden)

Victor Nwaoba ITUMO

2016-12-01

Full Text Available The article takes an insight into the nature of the oil based mono-cultural economy of Nigeria, providing an in-depth analysis of the situation. It clearly assesses the oil resource based economy, highlights the impacts- positive and negative on Nigeria’s economic development and why Nigeria urgently needs to diversify its economy away from oil resource dependence. If Nigeria will not change the oil dependency economy, there will be grave implications for its economic growth and development as it already negatively affects annual budgetary provisions and other fiscal responsibilities. As it is well known, Nigeria is one of the foremost countries in the global oil export, with disruptions in its supply affecting the international oil market in some ways, huge reliance on oil as a resource has seen one of the foremost economies in Africa challenged in her economic growth and development with oil price volatility and decline on the global market. The research made use of secondary data to assess the situation and also drew the conclusion that Nigeria needs to diversify her economy as reliance on a basic resource discourages growth.

Digital control card based on digital signal processor

International Nuclear Information System (INIS)

Hou Shigang; Yin Zhiguo; Xia Le

2008-01-01

A digital control card based on digital signal processor was developed. Two Freescale DSP-56303 processors were utilized to achieve 3 channels proportional- integral-differential regulations. The card offers high flexibility for 100 MeV cyclotron RF system development. It was used as feedback controller in low level radio frequency control prototype, with the feedback gain parameters continuously adjustable. By using high precision analog to digital converter with 500 kHz sampling rate, a regulation bandwidth of 20 kHz was achieved. (authors)

Fast digitizing and digital signal processing of detector signals

International Nuclear Information System (INIS)

Hannaske, Roland

2008-01-01

A fast-digitizer data acquisition system recently installed at the neutron time-of-flight experiment nELBE, which is located at the superconducting electron accelerator ELBE of Forschungszentrum Dresden-Rossendorf, is tested with two different detector types. Preamplifier signals from a high-purity germanium detector are digitized, stored and finally processed. For a precise determination of the energy of the detected radiation, the moving-window deconvolution algorithm is used to compensate the ballistic deficit and different shaping algorithms are applied. The energy resolution is determined in an experiment with γ-rays from a 22 Na source and is compared to the energy resolution achieved with analogously processed signals. On the other hand, signals from the photomultipliers of barium fluoride and plastic scintillation detectors are digitized. These signals have risetimes of a few nanoseconds only. The moment of interaction of the radiation with the detector is determined by methods of digital signal processing. Therefore, different timing algorithms are implemented and tested with data from an experiment at nELBE. The time resolutions achieved with these algorithms are compared to each other as well as to reference values coming from analog signal processing. In addition to these experiments, some properties of the digitizing hardware are measured and a program for the analysis of stored, digitized data is developed. The analysis of the signals shows that the energy resolution achieved with the 10-bit digitizer system used here is not competitive to a 14-bit peak-sensing ADC, although the ballistic deficit can be fully corrected. However, digital methods give better result in sub-ns timing than analog signal processing. (orig.)

Radiometric titration of diethanolamine with /sup 65/ZnSO/sub 4/ and determination of mono and diethanolamines in a mixture by a radiometric method

Energy Technology Data Exchange (ETDEWEB)

Varadan, R.; Sriman Narayanan, S.; Rao, V.R.S. (Indian Inst. of Tech., Madras. Dept. of Chemistry)

1984-08-16

Radiometric titration of diethanolamine with /sup 65/ZnSO/sub 4/ is reported. Determination of individual amounts of mono- and diethanolamines in a mixture is described. The procedure is simple, rapid and accurate.

Synthesis of the mono- and di(4-(1,1,3,3-tetramethylbutyl)) phosphoric acids

International Nuclear Information System (INIS)

Elias, H.; Zaoui, A.; Attou, M.; Hadj Bachir, D.; Bouzidi, N.; Didi, M.

1995-09-01

This work is related to the synthesis of organophosphorus extracting agents used in purification of heavy metals such as uranium. The mono- and di (4-(1,1,3,3- tetramethylbutyl)) phenyl phosphoric acids, respectively MOPPA and DOPPA, are synthesizd by reaction of phosphorus pentoxid with 4(1,1,3,3-tetramethylbuthyl)) phenol. the separation of MOPPA from DOPPA is realised by liquid-liquid extraction. The Characterization, carried out by infrared uv-visible spectrophotometries, ph-metry and mass spectrometry, has confirmed the identity of the synthesized products. This study also showed that the products proportions are comporable to those of the homologous products obtained with 2-ethylbexanol in the same synthesis conditions

Utilization of 14C-labelled cellulose in conventional, germ-free and mono-associated rats

International Nuclear Information System (INIS)

Juhr, N.C.; Franke, J.; Ratsch, H.

1987-01-01

This report deals with the ultilization of 14 C-labelled cellulose in conventional, defined associated, and germ-free rats. With conventional animals 35.8% of the administered 14 C dose can be demonstrated in the exhaled air, 5.9% in organs, and 3.9% in the urine. 58.6% could be identified as not utilized in the intestinal and fecal contents. Animals mono-associated with Bacteroides succinogenes have about the same utilization rate. The appearance of 14 C in the exhaled air, in organs and the urine of germ-free animals is caused by a part of 14 C-labelled starch in the used test material. (author)

New mono-organotin (IV) dithiocarbamate complexes

International Nuclear Information System (INIS)

Muthalib, Amirah Faizah Abdul; Baba, Ibrahim

2014-01-01

Eighteen new mono-organotin dithiocarbamate compounds derived each nine from methyltin(IV) and phenyltin(IV) reacted using in-situ method with various type of N-dialkylamine together with carbon disulphide with the ratio of 1:3:3. Elemental and gravimetric analysis showed that the general formula of these compounds were RSnCl[S 2 CNR′R″] 2 (R= Ph, CH 3 , R′ = CH 3 , C 2 H 5 , C 7 H 7 and R″ = C 2 H 5 , C 6 H 11 , iC 3 H 7 , C 7 H 7 ). These compounds had been characterized by infrared spectroscopy, ultraviolet spectroscopy, 1 H, 13 C NMR spectroscopy and single crystal X-ray crystallography. The infrared spectra of these compounds showed three important peaks indicating the formation of dithiocarbamate compounds, ν(C N), ν(C S) and ν(Sn-S) band which present in the region of 1444–1519, 954–1098 and 318–349 cm −1 respectively. The ultraviolet-visible spectra showed an absorption band for the π - π* transition of N C S group in the range of 253 – 259 nm due to the intramolecular charge transfer of the ligand. The 13 C NMR spectra showed an important shift for δ(N 13 CS 2 ) in the range of 196.8 – 201.9 ppm.. Single crystal X-ray diffraction studies showed three new structures with the general formula of PhSnCl[S 2 CN(Et)(i−Pr)] 2 , MeSnCl[S 2 CN(Me)(Cy)] 2 and MeSnCl[S 2 CN(i−Pr)(CH 2 Ph)] 2 . All structures having a distorted octahedral geometry set by CClS 4 donor atom from the two chelating dithiocarbamate ligands

A chicory cytochrome P450 mono-oxygenase CYP71AV8 for the oxidation of (+)-valencene

OpenAIRE

Cankar, K.; Houwelingen, van, A.M.M.L.; Bosch, H.J.; Sonke, Th.; Bouwmeester, H.J.; Beekwilder, M.J.

2011-01-01

Chicory (Cichorium intybus L.), which is known to have a variety of terpene-hydroxylating activities, was screened for a P450 mono-oxygenase to convert (+)-valencene to (+)-nootkatone. A novel P450 cDNA was identified in a chicory root EST library. Co-expression of the enzyme with a valencene synthase in yeast, led to formation of trans-nootkatol, cis-nootkatol and (+)-nootkatone. The novel enzyme was also found to catalyse a three step conversion of germacrene A to germacra-1(10),4,11(13)-tr...

Digital asset management.

Science.gov (United States)

Humphrey, Clinton D; Tollefson, Travis T; Kriet, J David

2010-05-01

Facial plastic surgeons are accumulating massive digital image databases with the evolution of photodocumentation and widespread adoption of digital photography. Managing and maximizing the utility of these vast data repositories, or digital asset management (DAM), is a persistent challenge. Developing a DAM workflow that incorporates a file naming algorithm and metadata assignment will increase the utility of a surgeon's digital images. Copyright 2010 Elsevier Inc. All rights reserved.

PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1.

Directory of Open Access Journals (Sweden)

Simone Di Paola

Full Text Available BACKGROUND: Protein mono-ADP-ribosylation is a reversible post-translational modification that modulates the function of target proteins. The enzymes that catalyze this reaction in mammalian cells are either bacterial pathogenic toxins or endogenous cellular ADP-ribosyltransferases. The latter include members of three different families of proteins: the well characterized arginine-specific ecto-enzymes ARTCs, two sirtuins and, more recently, novel members of the poly(ADP-ribose polymerase (PARP/ARTD family that have been suggested to act as cellular mono-ADP-ribosyltransferases. Here, we report on the characterisation of human ARTD15, the only known ARTD family member with a putative C-terminal transmembrane domain. METHODOLOGY/PRINCIPAL FINDINGS: Immunofluorescence and electron microscopy were performed to characterise the sub-cellular localisation of ARTD15, which was found to be associated with membranes of the nuclear envelope and endoplasmic reticulum. The orientation of ARTD15 was determined using protease protection assay, and is shown to be a tail-anchored protein with a cytosolic catalytic domain. Importantly, by combining immunoprecipitation with mass spectrometry and using cell lysates from cells over-expressing FLAG-ARTD15, we have identified karyopherin-ß1, a component of the nuclear trafficking machinery, as a molecular partner of ARTD15. Finally, we demonstrate that ARTD15 is a mono-ADP-ribosyltransferase able to induce the ADP-ribosylation of karyopherin-ß1, thus defining the first substrate for this enzyme. CONCLUSIONS/SIGNIFICANCE: Our data reveal that ARTD15 is a novel ADP-ribosyltransferase enzyme with a new intracellular location. Finally, the identification of karyopherin-ß1 as a target of ARTD15-mediated ADP-ribosylation, hints at a novel regulatory mechanism of karyopherin-ß1 functions.

Dissolution of different zinc salts and zn uptake by Sedum alfredii and maize in mono- and co-cropping under hydroponic culture.

Science.gov (United States)

Jiang, Cheng'ai; Wu, Qitang; Zeng, Shucai; Chen, Xian; Wei, Zebin; Long, Xinxian

2013-09-01

Previous soil pot and field experiments demonstrated that co-cropping the hyperaccumulator Sedum alfredii with maize increased Zn phytoextraction by S. alfredii and decreased Zn uptake by maize shoots. This hydroponic experiment was conducted to investigate whether the facilitation of Zn phytoextraction by S. alfredii resulted from improved dissolution in this co-cropping system and its relation to root exudates. S. alfredii and maize were mono- and co-cropped (without a root barrier) in nutrient solution spiked with four Zn compounds, ZnS, ZnO, Zn3(PO4)2 and 5ZnO x 2CO3-4H2O (represented as ZnCO3) at 1000 mg/L Zn for 15 days without renewal of nutrient solution after pre-culture. The root exudates were collected under incomplete sterilization and analyzed. The results indicated that the difference in Zn salts had a greater influence on the Zn concentration in maize than for S. alfredii, varying from 210-2603 mg/kg for maize shoots and 6445-12476 mg/kg for S. alfredii in the same order: ZnCO3 > ZnO > Zn3(PO4)2 > ZnS. For the four kinds of Zn sources in this experiment, co-cropping with maize did not improve Zn phytoextraction by S. alfredii. In most cases, compared to co-cropped and mono-cropped maize, mono-cropped S. alfredii resulted in the highest Zn2+ concentration in the remaining nutrient solution, and also had a higher total concentration of low molecular weight organic acids (LMWOA) and lower pH of root exudation. Root exudates did partly influence Zn hyperaccumulation in S. alfredii.

digital natives and digital immigrants

OpenAIRE

Cardina, Bruno; Francisco, Jerónimo; Reis, Pedro; trad. Silva, Fátima

2011-01-01

This article focuses on the generational gaps in school learning. Initially, we have tried to provide the framework in relation to the term digital native in order to understand the key aspects of the generation born after the advent and the global use of the Internet. They were found to be “multitasking” people, linked to technology and connectivity, as opposed to digital immigrants, born in an earlier period and seeking to adapt to the technological world. We also present some r...

Digital Downsides: Exploring University Students' Negative Engagements with Digital Technology

Science.gov (United States)

Selwyn, Neil

2016-01-01

Digital technologies are now an integral feature of university study. As such, academic research has tended to concentrate on the potential of digital technologies to support, extend and even "enhance" student learning. This paper, in contrast, explores the rather more messy realities of students' engagements with digital technology. In…

Building the digital enterprise a guide to constructing monetization models using digital technologies

CERN Document Server

Skilton, Mark

2016-01-01

The digital economy is at a tipping point. This practical book defines digital ecosystems, discusses digital design using converging technologies of social networking, mobility, big data and cloud computing, and provides a methods for linking digital technologies together to meet the challenges of building a digital enterprise in the new economy.

Comparison of skeletal stability after sagittal split ramus osteotomy among mono-cortical plate fixation, bi-cortical plate fixation, and hybrid fixation using absorbable plates and screws.

Science.gov (United States)

Ueki, Koichiro; Moroi, Akinori; Yoshizawa, Kunio; Hotta, Asami; Tsutsui, Takamitsu; Fukaya, Kenichi; Hiraide, Ryota; Takayama, Akihiro; Tsunoda, Tatsuta; Saito, Yuki

2017-02-01

The purpose of this study was to examine skeletal stability and plate breakage after sagittal split ramus osteotomy (SSRO) with the mono-cortical plate fixation, bi-cortical plate fixation, and hybrid fixation techniques using absorbable plates and screws. A total of 76 Japanese patients diagnosed with mandibular prognathism with and without maxillary deformity were divided into 3 groups randomly. A total of 28 patients underwent SSRO with mono-cortical plate fixation, 23 underwent SSRO with bi-cortical plate fixation, and 25 underwent SSRO with hybrid fixation. Skeletal stability and horizontal condylar angle were analyzed by axial, frontal, and lateral cephalograms from before the operation to 1 year postoperatively. Breakage of the plate and screws was observed by 3-dimensional computed tomography (3DCT) immediately after surgery and after 1 year. Although there was a significant difference between the mono-cortical plate fixation group and hybrid fixation group regarding right MeAg in T1 (P = 0.0488) and occlusal plane in T1 (P = 0.0346), there were no significant differences between the groups for the other measurements in each time interval. In 2 cases, namely, 6 sides in the mono-cortical plate fixation group, breakage of the absorbable plate was found by 3DCT. However, there was no breakage in the bi-cortical plate fixation group and hybrid fixation group. This study results suggested that there were no significant differences in the postoperative skeletal stability among the 3 groups, and bi-cortical fixation as well as hybrid fixation was a reliable and useful method to prevent plate breakage even if an absorbable material was used. Copyright © 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Effects of neutron irradiation on microstructure and deformation behaviour of mono- and polycrystalline molybdenum and its alloys

DEFF Research Database (Denmark)

Singh, B.N.; Evans, J.H.; Horsewell, A.

1998-01-01

The influence of neutron irradiation on microstructural evolution and mechanical properties of mono- and polycrystalline molybdenum and its alloys has been investigated. Tensile specimens and 3 mm diameter discs of monocrystals of pure molybdenum and Mo-5%Re were irradiated with fission neutrons...... microscopy are presented and discussed in terms of intracascade clustering of self-interstitial atoms and the role of one-dimensional glide of these clusters in controlling microstructural evolution and the resulting mechanical properties....

Digitally-Driven Architecture

Directory of Open Access Journals (Sweden)

Henriette Bier

2010-06-01

Full Text Available The shift from mechanical to digital forces architects to reposition themselves: Architects generate digital information, which can be used not only in designing and fabricating building components but also in embedding behaviours into buildings. This implies that, similar to the way that industrial design and fabrication with its concepts of standardisation and serial production influenced modernist architecture, digital design and fabrication influences contemporary architecture. While standardisa­tion focused on processes of rationalisation of form, mass-customisation as a new paradigm that replaces mass-production, addresses non-standard, complex, and flexible designs. Furthermore, knowledge about the designed object can be encoded in digital data pertaining not just to the geometry of a design but also to its physical or other behaviours within an environment. Digitally-driven architecture implies, therefore, not only digitally-designed and fabricated architecture, it also implies architecture – built form – that can be controlled, actuated, and animated by digital means. In this context, this sixth Footprint issue examines the influence of digital means as prag­matic and conceptual instruments for actuating architecture. The focus is not so much on computer-based systems for the development of architectural designs, but on architecture incorporating digital control, sens­ing, actuating, or other mechanisms that enable buildings to inter­act with their users and surroundings in real time in the real world through physical or sensory change and variation.

Progress in digital radiography

International Nuclear Information System (INIS)

Cappelle, A.

2016-01-01

Because of its practical aspect digital radiography is more and more used in the industrial sector. There are 2 kinds of digital radiography. First, the 'computed radiography' that uses a photon-stimulated screen, and after radiation exposure this screen must be read by an analyser to get a digit image. The second type is the 'direct radiography' that allows one to get a digit radiograph of the object directly. Digital radiography uses the same radioactive nuclides as radiography with silver films: cobalt, iridium or selenium. The spatial resolution of digital radiography is less good than with classical silver film radiography but digital radiography offers a better visual contrast. (A.C.)

[superscript 1]H NMR Spectroscopy-Based Configurational Analysis of Mono- and Disaccharides and Detection of ß-Glucosidase Activity: An Undergraduate Biochemistry Laboratory

Science.gov (United States)

Periyannan, Gopal R.; Lawrence, Barbara A.; Egan, Annie E.

2015-01-01

A [superscript 1]H NMR spectroscopy-based laboratory experiment explores mono- and disaccharide structural chemistry, and the enzyme-substrate specificity of glycosidic bond cleavage by ß-glucosidase towards cellobiose (ß-linked gluco-disaccharide) and maltose (a-linked gluco-disaccharide). Structural differences between cellobiose, maltose, and…

Ketone deprotonation mediated by mono- and heterobimetallic alkali and alkaline earth metal amide bases: structural characterization of potassium, calcium, and mixed potassium-calcium enolates.

Science.gov (United States)

He, Xuyang; Noll, Bruce C; Beatty, Alicia; Mulvey, Robert E; Henderson, Kenneth W

2004-06-23

Potassium, calcium, and mixed potassium-calcium amide combinations have been shown to be efficient reagents in enolization reactions, and a set of representative intermediate mono- and heterobimetallic enolates have been successfully isolated and crystallographically characterized.

Degradation of a mono sulfonated azo dye by an integrated bio sorption and anaerobic system

International Nuclear Information System (INIS)

Goncalves, L. C.; Campos, R.; Pinheiro, H. M.; Lopes, A.; Ferra, M. I.

2009-01-01

A simulated textile effluent containing a mono sulphonated azo dye was fed to an anaerobic bioreactor in which a natural adsorbent, spent brewery grains (SBG), was incorporated. SABG is a by-product of the brewing industry and could act as adsorbent as well an electron shuttle (lignin fraction) in the dye degradation mechanism. Furthermore, it can also work as a conditioner for the anaerobic biomass. The influence of the dye (Acid Orange 7, AO7) concentration (60 and 150 mg/L) and the presence of SBG in the performance of upflow anaerobic sludge blanket reactor (UASB) was evaluated. (Author)

Selfenergy effect on the magnetic ordering transition in the mono- and bilayer honeycomb Hubbard model

Energy Technology Data Exchange (ETDEWEB)

Honerkamp, Carsten [Institute for Theoretical Solid State Physics, RWTH Aachen University (Germany); JARA - Fundamentals of Future Information Technology, Aachen (Germany)

2017-11-15

We investigate the impact of electron self-energy corrections on potential antiferromagnetic ordering instabilities in mono- and bilayer graphene, modeled by a Hubbard-type lattice model with onsite interactions among the electrons, using a self-consistent random phase approximation (RPA). In qualitative agreement with earlier studies we find that the electronic interactions cause non-Fermi liquid behavior at low energies. In self-consistent RPA, the transition scales for antiferromagnetic ordering are renormalized significantly by these self-energy effects, both for interaction-driven and temperature-driven cases. (copyright 2017 by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Degradation of a mono sulfonated azo dye by an integrated bio sorption and anaerobic system

Energy Technology Data Exchange (ETDEWEB)

Goncalves, L. C.; Campos, R.; Pinheiro, H. M.; Lopes, A.; Ferra, M. I.

2009-07-01

A simulated textile effluent containing a mono sulphonated azo dye was fed to an anaerobic bioreactor in which a natural adsorbent, spent brewery grains (SBG), was incorporated. SABG is a by-product of the brewing industry and could act as adsorbent as well an electron shuttle (lignin fraction) in the dye degradation mechanism. Furthermore, it can also work as a conditioner for the anaerobic biomass. The influence of the dye (Acid Orange 7, AO7) concentration (60 and 150 mg/L) and the presence of SBG in the performance of upflow anaerobic sludge blanket reactor (UASB) was evaluated. (Author)

A digital silicon photomultiplier with multiple time-to-digital converters

Energy Technology Data Exchange (ETDEWEB)

Garutti, Erika [University Hamburg (Germany); Silenzi, Alessandro [DESY, Hamburg (Germany); Xu, Chen [DESY, Hamburg (Germany); University Hamburg (Germany)

2013-07-01

A silicon photomultiplier (SiPM) with pixel level signal digitization and column-wise connected time-to-digital converters (TDCs) has been developed for an endoscopic Positron Emission Tomography (PET) detector. A digital SiPM has pixels consist of a single photon avalanche diode (SPAD) and circuit elements to optimize overall dark counts and temporal response. Compared with conventional analog SiPM, digital SiPM's direct signal route from SPAD to TDC improves single photon time resolution. In addition, using multiple TDCs can perform the statistical estimation of the time-of-arrival in multiple photon detection case such as readout of scintillation crystals. Characterization measurements of the prototype digital SiPM and a Monte-Carlo simulation to predict the timing performance of the PET detector are shown.

Two-Step Injection Method for Collecting Digital Evidence in Digital Forensics

Directory of Open Access Journals (Sweden)

Nana Rachmana Syambas

2015-01-01

Full Text Available In digital forensic investigations, the investigators take digital evidence from computers, laptops or other electronic goods. There are many complications when a suspect or related person does not want to cooperate or has removed digital evidence. A lot of research has been done with the goal of retrieving data from flash memory or other digital storage media from which the content has been deleted. Unfortunately, such methods cannot guarantee that all data will be recovered. Most data can only be recovered partially and sometimes not perfectly, so that some or all files cannot be opened. This paper proposes the development of a new method for the retrieval of digital evidence called the Two-Step Injection method (TSI. It focuses on the prevention of the loss of digital evidence through the deletion of data by suspects or other parties. The advantage of this method is that the system works in secret and can be combined with other digital evidence applications that already exist, so that the accuracy and completeness of the resulting digital evidence can be improved. An experiment to test the effectiveness of the method was set up. The developed TSI system worked properly and had a 100% success rate.

The Abbey Theatre Digital Archive: a digitization project with dramatic impact

Directory of Open Access Journals (Sweden)

John Cox

2017-11-01

Full Text Available National University of Ireland Galway digitized the archive of the Abbey Theatre between 2012 and 2015. This was the largest theatre archive digitization project worldwide and it has had a major impact on the University and its Library. The scale of the digitization project presented a series of challenges, including fragile material, limited time, streamlined workflows, complex digital rights management and effective systems. The project was completed on time and on budget in 2015, using a ‘more product, less process’ approach. Access to the Abbey Theatre Digital Archive has delivered strong academic impact for the University, generating new research income and international connections as well as contributing to improved institutional ranking. The Digital Archive enables new types of research, including text and data mining, and has reshaped undergraduate curricula. It has also had a transformative effect on the Library as leader of the project. The role of the archivist has changed and partnerships with the academic community have strengthened. A growing emphasis on digital publication has been a catalyst for a function- rather than subject-based organizational structure which promotes participation in digital scholarship initiatives, with archives and special collections occupying a new position of prominence.

Metabolism of UC-labelled urea in conventional, germ-free and mono-associated rats

Energy Technology Data Exchange (ETDEWEB)

Juhr, N.C.; Franke, J.

1987-01-01

This report deals with the utilization of UC-labelled urea in conventional, defined associated and germ-free rats. With conventional animals 71.44% of the administered UC dose can be demonstrated in the exhaled air, 0.47% in organs and 27.35% in the urine. 1.04% was found in the intestinal and fecal contents. Animals mono-associated with Proteus mirabilis have nearly the same utilization rate (59.15, 0.34, 35.98, 2% resp.). In germ-free animals 1.21% of the activity appeared in the exhaled air and showed a small part of non-enzymatic hydrolysis of urea. The excretion of 97.70% in the urine shows that urea is absorbed from the intestine in germ-free animals.

Digital Image Quantitative Evaluations for Low Cost Film Digitizers Height Determination

International Nuclear Information System (INIS)

Khairul Anuar Mohd Salleh; Arshad Yassin; Ahmad Nasir Yusof; Noorhazleena Azaman

2016-01-01

Non Destructive Testing (NDT) technology contributes significant improvement to the quality of industrial products, and the integrity of equipment and plants. Introduction of powerful computers and reliable imaging technology has had significant impact on the traditional nuclear based NDT technology. Demand for faster, reliable, low cost, and flexible technology is rapidly increased. With the growing demand for more efficient digital archiving, digital image analysis, and reporting results with a low cost technology, one cannot deny the importance of having another cheaper solution. This project will apply fundamental principle of image digitization to be used in building up a low cost film digitization solution. The height of the film digitization was carefully determined by examining each digital images produced. Three (3) repetitive quantitative evaluations (Modulation Transfer Function [MTF], Characteristic Transfer Curve [CTC], and Contrast to Noise Ratio [CNR]) were performed at different condition to assist with the determination of the low cost film digitizers height. All 3 evaluations were successfully applied and the most appropriate height was successfully determined. (author)

Apparatus and method for managing digital resources by passing digital resource tokens between queues

Science.gov (United States)

Crawford, H.J.; Lindenstruth, V.

1999-06-29

A method of managing digital resources of a digital system includes the step of reserving token values for certain digital resources in the digital system. A selected token value in a free-buffer-queue is then matched to an incoming digital resource request. The selected token value is then moved to a valid-request-queue. The selected token is subsequently removed from the valid-request-queue to allow a digital agent in the digital system to process the incoming digital resource request associated with the selected token. Thereafter, the selected token is returned to the free-buffer-queue. 6 figs.

Experience with digital mammography

Directory of Open Access Journals (Sweden)

G. P. Korzhenkova

2011-01-01

Full Text Available The use of digital techniques in mammography has become a last step for completing the process of digitization in diagnostic imaging. It is assumed that such a spatial decision will be required for digital mammography, as well as for high-resolution intensifying screen-film systems used in conventional mammography and that the digital techniques will be limited by the digitizer pixel size on detecting minor structures, such as microcalcifications. The introduction of digital technologies in mammography involves a tight control over an image and assures its high quality.

Fuzzy topological digital space and digital fuzzy spline of electroencephalography during epileptic seizures

Science.gov (United States)

Shah, Mazlina Muzafar; Wahab, Abdul Fatah

2017-08-01

Epilepsy disease occurs because of there is a temporary electrical disturbance in a group of brain cells (nurons). The recording of electrical signals come from the human brain which can be collected from the scalp of the head is called Electroencephalography (EEG). EEG then considered in digital format and in fuzzy form makes it a fuzzy digital space data form. The purpose of research is to identify the area (curve and surface) in fuzzy digital space affected by inside epilepsy seizure in epileptic patient's brain. The main focus for this research is to generalize fuzzy topological digital space, definition and basic operation also the properties by using digital fuzzy set and the operations. By using fuzzy digital space, the theory of digital fuzzy spline can be introduced to replace grid data that has been use previously to get better result. As a result, the flat of EEG can be fuzzy topological digital space and this type of data can be use to interpolate the digital fuzzy spline.

Substituting poly- and mono-unsaturated fat for dietary carbohydrate reduces hyperinsulinemia in women with polycystic ovary syndrome.

Science.gov (United States)

Perelman, Dalia; Coghlan, Nicole; Lamendola, Cindy; Carter, Susan; Abbasi, Fahim; McLaughlin, Tracey

2017-04-01

Hyperinsulinemia is a prevalent feature of polycystic ovary syndrome (PCOS), contributing to metabolic and reproductive manifestations of the syndrome. Weight loss reduces hyperinsulinemia but weight regain is the norm, thus preventing long-term benefits. In the absence of weight loss, replacement of dietary carbohydrate (CHO) with mono/polyunsaturated fat reduces ambient insulin concentrations in non-PCOS subjects. The current study evaluated whether this dietary intervention could ameliorate hyperinsulinemia in women with PCOS. Obese women with PCOS (BMI 39 ± 7 kg/m 2 ) and insulin resistance completed a crossover study (Stanford University Clinical Research Center) comparing two isocaloric diets, prepared by research dietitians, containing 60% CHO/25% fat versus 40% CHO/45% fat (both 15% protein and ≤7% saturated fat). After 3 weeks on each diet, daylong glucose, insulin, and fasting lipid/lipoproteins were measured. Daylong glucose did not differ according to diet. Daylong insulin concentrations were substantially (30%) and significantly lower on the low CHO/higher fat diet. Beneficial changes in lipid profile were also observed. Replacement of dietary CHO with mono/polyunsaturated fat yields clinically important reductions in daylong insulin concentrations, without adversely affecting lipid profile in obese, insulin-resistant women with PCOS. This simple and safe dietary intervention may constitute an important treatment for PCOS. ClinicalTrials.gov Identifier: NCT00186459.

Electrical and spectroscopic analysis of mono- and multi-tip pulsed corona discharges in air at atmospheric pressure

Science.gov (United States)

Mraihi, A.; Merbahi, N.; Yousfi, M.; Abahazem, A.; Eichwald, O.

2011-12-01

This work is devoted to the analysis of experimental results obtained in dry air at atmospheric pressure in a positive point-to-plane corona discharge under a pulsed applied voltage in the cases of anodic mono- and multi-tips. In the mono-tip case, the peak corona current is analysed as a function of several experimental parameters such as magnitude, frequency and duration of pulsed voltage and gap distance. The variation of the corona discharge current is correlated with the ozone production. Then in the multi-tip case, the electrical behaviour is analysed as a function of the distance between two contiguous tips and the tip number in order to highlight the region of creation active species for the lowest dissipated power. Intensified charge-coupled device pictures and electric field calculations as a function of inter-tip distance are performed to analyse the mutual effect between two contiguous tips. The optical emission spectra are measured in the UV-visible-NIR wavelength range between 200 nm and 800 nm, in order to identify the main excited species formed in an air corona discharge such as the usual first and second positive systems with first negative systems of molecular nitrogen. The identification of atomic species (O triplet and N) and the quenching of NOγ emission bands are also emphasized.

Electrical and spectroscopic analysis of mono- and multi-tip pulsed corona discharges in air at atmospheric pressure

International Nuclear Information System (INIS)

Mraihi, A; Merbahi, N; Yousfi, M; Abahazem, A; Eichwald, O

2011-01-01

This work is devoted to the analysis of experimental results obtained in dry air at atmospheric pressure in a positive point-to-plane corona discharge under a pulsed applied voltage in the cases of anodic mono- and multi-tips. In the mono-tip case, the peak corona current is analysed as a function of several experimental parameters such as magnitude, frequency and duration of pulsed voltage and gap distance. The variation of the corona discharge current is correlated with the ozone production. Then in the multi-tip case, the electrical behaviour is analysed as a function of the distance between two contiguous tips and the tip number in order to highlight the region of creation active species for the lowest dissipated power. Intensified charge-coupled device pictures and electric field calculations as a function of inter-tip distance are performed to analyse the mutual effect between two contiguous tips. The optical emission spectra are measured in the UV–visible–NIR wavelength range between 200 nm and 800 nm, in order to identify the main excited species formed in an air corona discharge such as the usual first and second positive systems with first negative systems of molecular nitrogen. The identification of atomic species (O triplet and N) and the quenching of NOγ emission bands are also emphasized.

Digital curation: a proposal of a semi-automatic digital object selection-based model for digital curation in Big Data environments

Directory of Open Access Journals (Sweden)

Moisés Lima Dutra

2016-08-01

Full Text Available Introduction: This work presents a new approach for Digital Curations from a Big Data perspective. Objective: The objective is to propose techniques to digital curations for selecting and evaluating digital objects that take into account volume, velocity, variety, reality, and the value of the data collected from multiple knowledge domains. Methodology: This is an exploratory research of applied nature, which addresses the research problem in a qualitative way. Heuristics allow this semi-automatic process to be done either by human curators or by software agents. Results: As a result, it was proposed a model for searching, processing, evaluating and selecting digital objects to be processed by digital curations. Conclusions: It is possible to use Big Data environments as a source of information resources for Digital Curation; besides, Big Data techniques and tools can support the search and selection process of information resources by Digital Curations.

Digital work in a pre-digital organizational culture

NARCIS (Netherlands)

Davison, R.M.; Ou, C.X.J.; Te'eni, D.; Avgerou, C.

2014-01-01

Digital natives constitute the majority of new employees entering the marketplace. However, they face an organizational corporate culture that enshrines the vested interests of a very different generation of people, whom they would characterize as digital immigrants or even dinosaurs. This

Inclusão digital via acessibilidade web | Digital inclusion via web accessibility

Directory of Open Access Journals (Sweden)

Cesar Augusto Cusin

2009-03-01

Full Text Available Resumo A natureza atual da web, que destaca a participação colaborativa dos usuários em diversos ambientes informacionais digitais, conduz ao desenvolvimento de diretrizes que enfocam a arquitetura da informação digital inclusiva para diferentes públicos nas mais diversas ambiências informacionais. A pesquisa propõe e objetiva um ambiente informacional digital inclusivo, visando apontar os elementos de acessibilidade que permitam a promoção da inclusão informacional digital, de forma a destacar os referenciais da Arquitetura da Informação Digital, de recomendações internacionais, com o olhar da Ciência da Informação e das novas tecnologias de informação e comunicação (TIC. Palavras-chave inclusão digital; web; acessibilidade; ciência da informação; arquitetura da informação. Abstract The current nature of the web, which highlights the collaborative participation of users in various digital informational environments, leads to the development of guidelines that focus on the digital inclusive information architecture for different audiences in diverse informational environments. The study proposes an inclusive digital information environment, aiming to establish the elements of accessibility that  enable the promotion of digital inclusion information in order to highlight the references of digital information architecture, the international recommendations, with the perspective of Information Science and the new information and communication technologies (ICT. Keywords digital inclusion; web; accessibility; information science; information architecture.

Digital Signage

OpenAIRE

Fischer, Karl Peter

2011-01-01

Digital Signage for in-store advertising at gas stations/retail stores in Germany: A field study Digital Signage networks provide a novel means of advertising with the advantage of easily changeable and highly customizable animated content. Despite the potential and increasing use of these media empirical research is scarce. In a field study at 8 gas stations (with integrated convenience stores) we studied the effect of digital signage advertising on sales for different products and servi...

Study of the dissolution of three synthetic minerals: zirconolite, Y-britholite and mono-silicate fluor-apatite; Etude de la solubilite de trois mineraux synthetiques: la zirconolite, la britholite-Y et la fluorapatite monosilicatee

Energy Technology Data Exchange (ETDEWEB)

Kamel, N.E.H.; Telmoune, S.A. [Centre de Recherche Nucleaire d' Alger, Div. des Techniques Nucleaires, Alger (Algeria); Ait-Amar, H. [Unitersite des Sciences et de la Technologie Houari Boumediene, Dept. de Genie des Procedes, Alger (Algeria)

2007-11-15

In this study, we were interested in the synthesis by natural sintering of three minerals analogue of natural rocks: zirconolite, Y-britholite and mono-silicated fluor-apatite. Cerium was used as an actinide surrogate. A simple physical characterization of the materials was made by X-ray diffraction and by measuring both densities and hardnesses. A static leaching test allowed determining the cerium immobilization capacity of the minerals. The most stable mineral was mono-silicated fluor-apatite, with a maximum amount of released cerium less than 2 %. For zirconolite and Y-britholite, this amount reached 15 and 18 % of the total cerium in the minerals, respectively. For the latter compounds, the cerium content in the materials was too weak, and the chosen synthesis method gave less satisfactory physicochemical mineral properties compared to those obtained for mono-silicated fluor-apatite. (authors)

Digital Technology Entrepreneurship

DEFF Research Database (Denmark)

Giones, Ferran; Brem, Alexander

2017-01-01

Technology entrepreneurship is an established concept in academia. However, recent developments in the context of digital entrepreneurship call for revision and advance- ment. The multiple possible combinations of technology and entrepreneurship have res- ulted in a diversity of phenomena...... with significantly different characteristics and socio-economic impact. This article is focused on the identification and description of technology entrepreneurship in times of digitization. Based on current examples, we identify and describe characterizations of technology entrepreneurship, digital techno- logy...... entrepreneurship, and digital entrepreneurship. With this new delineation of terms, we would like to foster discussion between researchers, entrepreneurs, and policy makers on the impact of digitization on entrepreneurship, and set a future research agenda....

Digital Tectonic Tools

DEFF Research Database (Denmark)

Schmidt, Anne Marie Due

2005-01-01

Tectonics has been an inherent part of the architectural field since the Greek temples while the digital media is new to the field. This paper is built on the assumption that in the intermediate zone between the two there is a lot to be learned about architecture in general and the digital media...... in particular. A model of the aspects in the term tectonics – epresentation, ontology and culture – will be presented and used to discuss the current digital tools’ ability in tectonics. Furthermore it will be discussed what a digital tectonic tool is and could be and how a connection between the digital...... and tectonic could become a part of the architectural education....

Mono-colonization with Lactobacillus acidophilus NCFM affects the intestinal metabolome as compared to germ-free mice

DEFF Research Database (Denmark)

Roager, Henrik Munch; Sulek, Karolina; Skov, Kasper

Every single species of the gut microbiota produce low-molecular-weight compounds that are absorbed constantly from the intestinal lumen and carried to systemic circulation where they play a direct role in health and disease. However, very few studies address the host metabolome as a function...... of colonizing bacteria. In this study the effect of the Lactobacillus acidophilus NCFM strain was investigated by comparing the metabolome of mono-colonized and germ-free mice in several compartments. By liquid-chromatography coupled to mass spectrometry, we were able to show that the metabolome differed...

A simple method of digitizing analog scintigrams for quantification and digital archiving

International Nuclear Information System (INIS)

Schramm, M.; Kaempfer, B.; Wolf, H.; Clausen, M.; Wendhausen, H.; Henze, E.

1993-01-01

This study was undertaken to evaluate a quick, reliable and cheap method of digitizing analog scintigrams. 40 whole-body bone scintigrams were obtained simultaneously in analog and genuine digital format. The analog scans on X-ray film were then digitized seecondarily by three different methods: 300 dpi flatbed scanning, high-resolution camera scanning and camcorder recording. A simple exposure approach using a light box, a cheap camcorder, a PC and image grabber hard- and software proved to be optimal. Visual interpretation showed no differences in clinical findings when comparing the analog images with their secondarily digitized counterparts. To test the possibility of quantification, 126 equivalent ROIs were drawn both in the genuine digital and the secondarily digitized images. Comparing the ROI count to whole-body count percentage of the corresponding ROIs showed the correlation to be linear. The evaluation of phantom studies showed the linear correlation to be true within a wide activity range. Thus, secondary digitalization of analog scintigrams is an easy, cheap and reliable method of archiving images and allows secondary digital quantification. (orig.) [de

[A simple method of digitizing analog scintigrams for quantification and digital archiving].

Science.gov (United States)

Schramm, M; Kämpfer, B; Wolf, H; Clausen, M; Wendhausen, H; Henze, E

1993-02-01

This study was undertaken to evaluate a quick, reliable and cheap method of digitizing analog scintigrams. 40 whole-body bone scintigrams were obtained simultaneously in analog and genuine digital format. The analog scans on x-ray film were then digitized secondarily by three different methods: 300 dpi flat-bed scanning, high-resolution camera scanning and camcorder recording. A simple exposure approach using a light box, a cheap camcorder, a PC and image grabber hard- and software proved to be optimal. Visual interpretation showed no differences in clinical findings when comparing the analog images with their secondarily digitized counterparts. To test the possibility of quantification, 126 equivalent ROIs were drawn both in the genuine digital and the secondarily digitized images. Comparing the ROI count to whole-body count percentage of the corresponding ROIs showed the correlation to be linear. The evaluation of phantom studies showed the linear correlation to be true within a wide activity range. Thus, secondary digitalization of analog scintigrams is an easy, cheap and reliable method of archiving images and allows secondary digital quantification.

Oxygen vacancies in oxides studied by annihilation of mono-energetic positrons

Energy Technology Data Exchange (ETDEWEB)

Hugenschmidt, Christoph; Pikart, Philip [ZWE FRM II, Technische Universitaet Muenchen, Lichtenbergstrasse 1, 85747 Garching (Germany); Physik-Department E21, Technische Universitaet Muenchen, James-Franck-Strasse, 85748 Garching (Germany); Schreckenbach, Klaus [Physik-Department E21, Technische Universitaet Muenchen, James-Franck-Strasse, 85748 Garching (Germany)

2009-07-01

Oxygen vacancies play a fundamental role for the material properties of various oxides, e.g. charge carrier density in high-Tc superconductors, magnetic properties of diluted magnetic semiconductors or paramagnetic properties of SiO{sub 2}. In this study, open volume defects in (metal) oxides are investigated by Doppler-broadening spectroscopy (DBS) of the positron annihilation. More detailed information about the chemical surrounding at the positron annihilation site is gained by additional coincident DBS experiments, where a signature of positrons annihilating with electrons from oxygen is observed. The mono-energetic positron beam at NEPOMUC was used which allows depth dependent measurements, and hence the investigation of thin oxide layers. Recent results for metallic oxides such as ZnO are presented and compared with various non-metallic oxides such as amorphous and crystalline SiO{sub 2}, oxygen terminated Si-surface, and ice. The role of neutral and charged oxygen vacancies and the application of the positron annihilation technique to study oxygen vacancies will be discussed.

Study of gamma propagation by using the ZEUS mono-kinetic code

International Nuclear Information System (INIS)

Vergnaud, Therese

1969-10-01

As studies of radiation protection often require the knowledge of heating due to capture gamma of thermal neutrons, the authors report an attempt of assessment of neutrons and γ propagation by using the same code (Zeus) which computes particle scattering by implementing a mono-kinetic Monte Carlo method. With this method, it is possible to study rather complex geometries and gamma source distributions directly obtained by a previous calculation of thermal neutrons. However, this method is not suitable for the study of energy degradation of gamma rays during their propagation. An approximate shock law is used to take shock-induced energy loss into account. This method is tested for different materials or media (either light like water and aluminium, or heavy like iron). Results are compared with those obtained by Goldstein with the method of moments. Results obtained by using Zeus are discussed: some of them appear to be over-estimated [fr

Mechanism of manganese (mono and di) telluride thin-film formation and properties

Science.gov (United States)

Sharma, Raj Kishore; Singh, Gurmeet; Shul, Yong Gun; Kim, Hansung

2007-03-01

Mechanistic studies on the electrocrystallization of manganese telluride (MnTe) thin film are reported using aqueous acidic solution containing MnSO 4 and TeO 2. Tartaric acid was used for the inhibition of hydrated manganese oxide anodic growth at counter electrode. A detailed study on the mechanistic aspect of electrochemical growth of MnTe using cyclic voltametry is carried out. Conditions for electrochemical growth of manganese mono and di telluride thin films have been reported using cyclic voltammetric scans for Mn 2+, Te 4+ and combined Mn 2+ and Te 4+. X-ray diffraction showed the formation of polycrystalline MnTe films with cubic, hexagonal and orthorhombic mixed phases. MnTe film morphology was studied using scanning electron microscope. Susceptibility and electrical characterization supports the anti-ferromagnetic behavior of the as-deposited MnTe thin film.

Mono-static GPR without transmitting anything for pavement damage inspection: interferometry by auto-correlation applied to mobile phone signals

Science.gov (United States)

Feld, R.; Slob, E. C.; Thorbecke, J.

2015-12-01

Creating virtual sources at locations where physical receivers have measured a response is known as seismic interferometry. A much appreciated benefit of interferometry is its independence of the actual source locations. The use of ambient noise as actual source is therefore not uncommon in this field. Ambient noise can be commercial noise, like for example mobile phone signals. For GPR this can be useful in cases where it is not possible to place a source, for instance when it is prohibited by laws and regulations. A mono-static GPR antenna can measure ambient noise. Interferometry by auto-correlation (AC) places a virtual source on this antenna's position, without actually transmitting anything. This can be used for pavement damage inspection. Earlier work showed very promising results with 2D numerical models of damaged pavement. 1D and 2D heterogeneities were compared, both modelled in a 2D pavement world. In a 1D heterogeneous model energy leaks away to the sides, whereas in a 2D heterogeneous model rays can reflect and therefore still add to the signal reconstruction (see illustration). In the first case the amount of stationary points is strictly limited, while in the other case the amount of stationary points is very large. We extend these models to a 3D world and optimise an experimental configuration. The illustration originates from the journal article under submission 'Non-destructive pavement damage inspection by mono-static GPR without transmitting anything' by R. Feld, E.C. Slob, and J.W. Thorbecke. (a) 2D heterogeneous pavement model with three irregular-shaped misalignments between the base and subbase layer (marked by arrows). Mono-antenna B-scan positions are shown schematically. (b) Ideal output: a real source at the receiver's position. The difference w.r.t. the trace found in the middle is shown. (c) AC output: a virtual source at the receiver's position. There is a clear overlap with the ideal output.

Isoniazid Mono-Resistant Tuberculosis: Impact on Treatment Outcome and Survival of Pulmonary Tuberculosis Patients in Southern Mexico 1995-2010.

Science.gov (United States)

Báez-Saldaña, Renata; Delgado-Sánchez, Guadalupe; García-García, Lourdes; Cruz-Hervert, Luis Pablo; Montesinos-Castillo, Marlene; Ferreyra-Reyes, Leticia; Bobadilla-Del-Valle, Miriam; Canizales-Quintero, Sergio; Ferreira-Guerrero, Elizabeth; Téllez-Vázquez, Norma; Montero-Campos, Rogelio; Yanes-Lane, Mercedes; Mongua-Rodriguez, Norma; Martínez-Gamboa, Rosa Areli; Sifuentes-Osornio, José; Ponce-de-León, Alfredo

2016-01-01

Isoniazid mono-resistance (IMR) is the most common form of mono-resistance; its world prevalence is estimated to range between 0.0 to 9.5% globally. There is no consensus on how these patients should be treated. To describe the impact of IMR tuberculosis (TB) on treatment outcome and survival among pulmonary TB patients treated under programmatic conditions in Orizaba, Veracruz, Mexico. We conducted a prospective cohort study of pulmonary TB patients in Southern Mexico. From 1995 to 2010 patients with acid-fast bacilli or culture proven Mycobacterium tuberculosis in sputum samples underwent epidemiological, clinical and microbiological evaluation. We included patients who harbored isoniazid mono-resistant (IMR) strains and patients with strains susceptible to isoniazid, rifampicin, ethambutol and streptomycin. All patients were treated following Mexican TB Program guidelines. We performed annual follow-up to ascertain treatment outcome, recurrence, relapse and mortality. Between 1995 and 2010 1,243 patients with pulmonary TB were recruited; 902/1,243 (72.57%) had drug susceptibility testing; 716 (79.38%) harbored pan-susceptible and 88 (9.75%) IMR strains. Having any contact with a person with TB (adjusted odds ratio (aOR)) 1.85, 95% Confidence interval (CI) 1.15-2.96) and homelessness (adjusted odds ratio (aOR) 2.76, 95% CI 1.08-6.99) were associated with IMR. IMR patients had a higher probability of failure (adjusted hazard ratio (HR) 12.35, 95% CI 3.38-45.15) and death due to TB among HIV negative patients (aHR 3.30. 95% CI 1.00-10.84). All the models were adjusted for socio-demographic and clinical variables. The results from our study provide evidence that the standardized treatment schedule with first line drugs in new and previously treated cases with pulmonary TB and IMR produces a high frequency of treatment failure and death due to tuberculosis. We recommend re-evaluating the optimal schedule for patients harboring IMR. It is necessary to strengthen

Managing digital evidence: the governance of digital forensics

CSIR Research Space (South Africa)

Grobler, MM

2010-01-01

Full Text Available and documentation of digital evidence stored as data or magnetically encoded information (Vacca 2002:731). This extends to include the recovery, analysis and presentation of digital evidence in a way that is admissible and appropriate in a court of law...

Towards Trustable Digital Evidence with PKIDEV: PKI Based Digital Evidence Verification Model

Science.gov (United States)

Uzunay, Yusuf; Incebacak, Davut; Bicakci, Kemal

How to Capture and Preserve Digital Evidence Securely? For the investigation and prosecution of criminal activities that involve computers, digital evidence collected in the crime scene has a vital importance. On one side, it is a very challenging task for forensics professionals to collect them without any loss or damage. On the other, there is the second problem of providing the integrity and authenticity in order to achieve legal acceptance in a court of law. By conceiving digital evidence simply as one instance of digital data, it is evident that modern cryptography offers elegant solutions for this second problem. However, to our knowledge, there is not any previous work proposing a systematic model having a holistic view to address all the related security problems in this particular case of digital evidence verification. In this paper, we present PKIDEV (Public Key Infrastructure based Digital Evidence Verification model) as an integrated solution to provide security for the process of capturing and preserving digital evidence. PKIDEV employs, inter alia, cryptographic techniques like digital signatures and secure time-stamping as well as latest technologies such as GPS and EDGE. In our study, we also identify the problems public-key cryptography brings when it is applied to the verification of digital evidence.

Digital Immigrants and Digital Natives: Learning Business Informatics at Higher Educational Level

Directory of Open Access Journals (Sweden)

Suša Dalia

2014-09-01

Full Text Available Background: The term digital natives refer to those born since the 1980s and have been growing up surrounded by technology. On the other hand, digital immigrants are born before 1980s and learned how to use technology later in life. Objectives: Goal of the paper is to explore attitudes of digital native students on the course of Business Informatics at higher educational institutions (HEIs, and to compare them with attitudes of digital immigrants. Methods/Approach: The survey was conducted in 2014 using the sample of first-year Business Informatics students from the Faculty of Economics and Business in Zagreb, Croatia. Results were compared with a research conducted in 1998. Results: In comparison to an earlier research, digital natives perceive their level of competency in the subject of Business Informatics before teaching practices much higher compared to digital immigrants. However, there is still an increase in digital native students’ level of competency in the subject before and after teaching practices. Conclusions: The research confirms a shift from digital immigrants to digital natives who show high level of interest for Business Informatics course topics and find its utility very high. However, constant improvement of delivering knowledge is needed in order to keep these high levels.

High-resolution tephrochronology of the Wilson Creek Formation (Mono Lake, California) and Laschamp event using 238U-230Th SIMS dating of accessory mineral rims

Science.gov (United States)

Vazquez, Jorge A.; Lidzbarski, Marsha I.

2012-12-01

Sediments of the Wilson Creek Formation surrounding Mono Lake preserve a high-resolution archive of glacial and pluvial responses along the eastern Sierra Nevada due to late Pleistocene climate change. An absolute chronology for the Wilson Creek stratigraphy is critical for correlating the paleoclimate record to other archives in the western U.S. and the North Atlantic region. However, multiple attempts to date the Wilson Creek stratigraphy using carbonates and tephras yield discordant results due to open-system effects and radiocarbon reservoir uncertainties as well as abundant xenocrysts. New ion microprobe 238U-230Th dating of the final increments of crystallization recorded by allanite and zircon autocrysts from juvenile pyroclasts yield ages that effectively date eruption of key tephra beds and delimit the timing of basal Wilson Creek sedimentation to the interval between 26.8±2.1 and 61.7±1.9 ka. Tephra (Ash 15) erupted during the geomagnetic excursion originally designated the Mono Lake excursion yields an age of 40.8±1.9 ka, indicating that the event is instead the Laschamp excursion. The new ages support a depositional chronology from magnetostratigraphy that indicates quasi-synchronous glacial and hydrologic responses in the Sierra Nevada and Mono Basin to regional climate change, with intervals of lake filling and glacial-snowpack melting that are in phase with peaks in spring insolation.

Biofilm formation by Staphylococcus aureus and Salmonella spp. under mono and dual-species conditions and their sensitivity to cetrimonium bromide, peracetic acid and sodium hypochlorite

Directory of Open Access Journals (Sweden)

Maricarmen Iñiguez-Moreno

Full Text Available Abstract The aim of this study was evaluated the biofilm formation by Staphylococcus aureus 4E and Salmonella spp. under mono and dual-species biofilms, onto stainless steel 316 (SS and polypropylene B (PP, and their sensitivity to cetrimonium bromide, peracetic acid and sodium hypochlorite. The biofilms were developed by immersion of the surfaces in TSB by 10 d at 37 °C. The results showed that in monospecies biofilms the type of surface not affected the cellular density (p > 0.05. However, in dual-species biofilms on PP the adhesion of Salmonella spp. was favored, 7.61 ± 0.13 Log10 CFU/cm2, compared with monospecies biofilms onto the same surface, 5.91 ± 0.44 Log10 CFU/cm2 (p < 0.05. The mono and dual-species biofilms were subjected to disinfection treatments; and the most effective disinfectant was peracetic acid (3500 ppm, reducing by more than 5 Log10 CFU/cm2, while the least effective was cetrimonium bromide. In addition, S. aureus 4E and Salmonella spp. were more resistant to the disinfectants in mono than in dual-species biofilms (p < 0.05. Therefore, the interspecies interactions between S. aureus 4E and Salmonella spp. had a negative effect on the antimicrobial resistance of each microorganism, compared with the monospecies biofilms.

High-resolution tephrochronology of the Wilson Creek Formation (Mono Lake, California) and Laschamp event using 238U-230Th SIMS dating of accessory mineral rims

Science.gov (United States)

Vazquez, Jorge A.; Lidzbarski, Marsha I.

2012-01-01

Sediments of the Wilson Creek Formation surrounding Mono Lake preserve a high-resolution archive of glacial and pluvial responses along the eastern Sierra Nevada due to late Pleistocene climate change. An absolute chronology for the Wilson Creek stratigraphy is critical for correlating the paleoclimate record to other archives in the western U.S. and the North Atlantic region. However, multiple attempts to date the Wilson Creek stratigraphy using carbonates and tephras yield discordant results due to open-system effects and radiocarbon reservoir uncertainties as well as abundant xenocrysts. New ion microprobe 238U-230Th dating of the final increments of crystallization recorded by allanite and zircon autocrysts from juvenile pyroclasts yield ages that effectively date eruption of key tephra beds and delimit the timing of basal Wilson Creek sedimentation to the interval between 26.8±2.1 and 61.7±1.9 ka. Tephra (Ash 15) erupted during the geomagnetic excursion originally designated the Mono Lake excursion yields an age of 40.8±1.9 ka, indicating that the event is instead the Laschamp excursion. The new ages support a depositional chronology from magnetostratigraphy that indicates quasi-synchronous glacial and hydrologic responses in the Sierra Nevada and Mono Basin to regional climate change, with intervals of lake filling and glacial-snowpack melting that are in phase with peaks in spring insolation.

Biodegradation of phthalic acid esters (PAEs) and in silico structural characterization of mono-2-ethylhexyl phthalate (MEHP) hydrolase on the basis of close structural homolog.

Science.gov (United States)

Singh, Neha; Dalal, Vikram; Mahto, Jai Krishna; Kumar, Pravindra

2017-09-15

Three bacterial strains capable of degrading phthalates namely Pseudomonas sp. PKDM2, Pseudomonas sp. PKDE1 and Pseudomonas sp. PKDE2 were isolated and characterized for their degradative potential. These strains efficiently degraded 77.4%-84.4% of DMP, 75.0%-75.7% of DEP and 71.7%-74.7% of DEHP, initial amount of each phthalate is 500mgL -1 of each phthalate, after 44h of incubation. GC-MS results reveal the tentative DEHP degradation pathway, where hydrolases mediate the breakdown of DEHP to phthalic acid (PA) via an intermediate MEHP. MEHP hydrolase is a serine hydrolase which is involved in the reduction of the MEHP to PA. The predicted 3D model of MEHP hydrolase from Pseudomonas mosselii was docked with phthalate monoesters (PMEs) such as MEHP, mono-n-hexyl phthalate (MHP), mono-n-butyl phthalate (MBP) and mono-n-ethyl phthalate (MEP), respectively. Docking results show the distance between the carbonyl carbon of respective phthalate monoester and the hydroxyl group of catalytic serine lies in the range of 2.9 to 3.3Å, which is similar to the ES complex of other serine hydrolases. This structural study highlights the interaction and the role of catalytic residues of MEHP hydrolase involved in the biodegradation of PMEs to phthalate. Copyright © 2017 Elsevier B.V. All rights reserved.

Digital cine-imaging

International Nuclear Information System (INIS)

Masuda, Kazuhiro

1992-01-01

Digitization of fluoroscopic images has been developed for the digital cine imaging system as a result of the computer technology, television technology, and popularization of interventional radiology. Present digital cine imaging system is able to offer images similar to cine film because of the higher operatability and better image quality with the development of interventional radiology. As a result, its higher usefulness for catheter diagnosis examination except for interventional radiology was reported, and the possibility of having filmless cine is close to becoming a reality. However several problems have been pointed out, such as spatial resolution, time resolution, storage and exchangeability of data, disconsolidated viewing functions, etc. Anyhow, digital cine imaging system has some unresolved points and lots the needs to be discussed. The tendency of digitization is the passage of the time and we have to promote a study for more useful digital cine imaging system in team medical treatment which centers on the patients. (author)

Digital electronics

CERN Document Server

Morris, John

2013-01-01

An essential companion to John C Morris's 'Analogue Electronics', this clear and accessible text is designed for electronics students, teachers and enthusiasts who already have a basic understanding of electronics, and who wish to develop their knowledge of digital techniques and applications. Employing a discovery-based approach, the author covers fundamental theory before going on to develop an appreciation of logic networks, integrated circuit applications and analogue-digital conversion. A section on digital fault finding and useful ic data sheets completes th

Digital Snaps

DEFF Research Database (Denmark)

Sandbye, Mette; Larsen, Jonas

. Distance as the New Punctum / Mikko Villi -- pt. II. FAMILY ALBUMS IN TRANSITION -- ch. 4. How Digital Technologies Do Family Snaps, Only Better / Gillian Rose -- ch. 5. Friendship Photography: Memory, Mobility and Social Networking / Joanne Garde-Hansen -- ch. 6. Play, Process and Materiality in Japanese...... -- ch. 9. Retouch Yourself: The Pleasures and Politics of Digital Cosmetic Surgery / Tanya Sheehan -- ch. 10. Virtual Selves: Art and Digital Autobiography / Louise Wolthers -- ch. 11. Mobile-Media Photography: New Modes of Engagement / Michael Shanks and Connie Svabo....

Logic of the digital

CERN Document Server

Evens, Aden

2015-01-01

Building a foundational understanding of the digital, Logic of the Digital reveals a unique digital ontology. Beginning from formal and technical characteristics, especially the binary code at the core of all digital technologies, Aden Evens traces the pathways along which the digital domain of abstract logic encounters the material, human world. How does a code using only 0s and 1s give rise to the vast range of applications and information that constitutes a great and growing portion of our world? Evens' analysis shows how any encounter between the actual and the digital must cross an ontolo

Prevalence and correlates of cigarette smoking among Chinese schizophrenia inpatients receiving antipsychotic mono-therapy.

Directory of Open Access Journals (Sweden)

Yan-Min Xu

Full Text Available OBJECTIVE: To investigate the prevalence rate of cigarette smoking and its socio-demographic and clinical correlates in Chinese schizophrenia inpatients receiving antipsychotic mono-therapy. METHODS: This study was a cross-sectional, two-site, hospital-based survey. Four hundred and twenty-nine schizophrenia patients (male/female: 66.9% vs. 33.1% were consecutively recruited from psychosis inpatient wards of two large specialty psychiatric hospitals in mainland China. Patients were assessed using a cigarette smoking questionnaire, the Positive and Negative Symptom Scale, the Simpson Angus Scale, the Barnes Akathisia Rating Scale, and the Abnormal Involuntary Movement Scale. Socio-demographic and other clinical data were also collected. We calculated the prevalence of current smoking in our sample as well as its indirectly standardized prevalence ratio (ISPR using data from the 2010 Global Adult Tobacco Survey in China. RESULTS: The prevalence rate of current smoking was 40.6% in our sample, and 57.5% in males and 6.3% in females. The ISPRs of all patients, men and women were 1.11(95%CI: 0.95 ∼ 1.29, 1.07(95%CI = 0.91 ∼ 1.24 and 4.64(95% CI = 2.12 ∼ 8.82, respectively. The overall and male-specific prevalence of current smoking did not differ significantly between patients and the general population. In multiple logistic regression analysis, male sex, older age, poor marital status, alcohol use, use of first-generation antipsychotics, longer duration of illness, more frequent hospitalizations, and more severe negative symptoms were independently associated with current smoking. CONCLUSION: Male Chinese inpatients with schizophrenia who received a mono-therapy of antipsychotics were not more likely to smoke than the general population. Cigarette smoking is more common in schizophrenia patients with more severe illness.

Description of the digital formats of electronic documents used in digital library

International Nuclear Information System (INIS)

Galabova, Sevdalina; Trencheva, Tereza; Trenchev, Ivan

2009-01-01

A digital library is a library where collections are stored in electronic formats and are easy to be accessed by computers. The digital content may be stored by local machine, or accessed remotely via computer networks. A digital library is a type of information retrieval system. In this paper we will present a few digital format as pdf, djvu and etc. It will be denote the specific of the formats, their history and licenses policy. We will discuss different similarities between these formats.. Keywords: digital library, electronic formats, pdf, djvu

Crime and Justice in Digital Society: Towards a ‘Digital Criminology’?

Directory of Open Access Journals (Sweden)

Greg Stratton

2017-05-01

Full Text Available The opportunities afforded through digital and communications technologies, in particular social media, have inspired a diverse range of interdisciplinary perspectives exploring how such advancements influence the way we live. Rather than positioning technology as existing in a separate space to society more broadly, the ‘digital society’ is a concept that recognises such technologies as an embedded part of the larger social entity and acknowledges the incorporation of digital technologies, media, and networks in our everyday lives (Lupton 2014, including in crime perpetration, victimisation and justice. In this article, we explore potential for an interdisciplinary concept of digital society to expand and inspire innovative crime and justice scholarship within an emerging field of ‘digital criminology’.

Digital Therapeutics: An Integral Component of Digital Innovation in Drug Development.

Science.gov (United States)

Sverdlov, Oleksandr; van Dam, Joris; Hannesdottir, Kristin; Thornton-Wells, Tricia

2018-07-01

Digital therapeutics represent a new treatment modality in which digital systems such as smartphone apps are used as regulatory-approved, prescribed therapeutic interventions to treat medical conditions. In this article we provide a critical overview of the rationale for investing in such novel modalities, including the unmet medical needs addressed by digital therapeutics and the potential for reducing current costs of medical care. We also discuss emerging pathways to regulatory approval and how innovative business models are enabling further growth in the development of digital therapeutics. We conclude by providing some recent examples of digital therapeutics that have gained regulatory approval and highlight opportunities for the near future. © 2018 American Society for Clinical Pharmacology and Therapeutics.

Digital Discretion

DEFF Research Database (Denmark)

Busch, Peter Andre; Zinner Henriksen, Helle

2018-01-01

discretion is suggested to reduce this footprint by influencing or replacing their discretionary practices using ICT. What is less researched is whether digital discretion can cause changes in public policy outcomes, and under what conditions such changes can occur. Using the concept of public service values......This study reviews 44 peer-reviewed articles on digital discretion published in the period from 1998 to January 2017. Street-level bureaucrats have traditionally had a wide ability to exercise discretion stirring debate since they can add their personal footprint on public policies. Digital......, we suggest that digital discretion can strengthen ethical and democratic values but weaken professional and relational values. Furthermore, we conclude that contextual factors such as considerations made by policy makers on the macro-level and the degree of professionalization of street...

Concept of digital nomad: fundamental risks of digital economy development

Directory of Open Access Journals (Sweden)

Elena Lyudvigovna Iakovleva

2017-12-01

Full Text Available Objective to identify the key risks of the digital economy development. Methods abstractlogical and dialectical methods. Results a modern individual cannot imagine their life without digital devices which facilitate their functioning and enable them to be included into the virtual space. The role of digital economy in the changes in all spheres of human life is analyzed in the article. With the growing role of the digital economy the approaches to business models formation are changing as well as the role of digital assets. This also leads to the transformation of human behavior the new risks of the digital economy accelerated development. In this regard the article characterizes an individual as a digital nomad defines the features of their behavior in the socioeconomic environment and highlights the main risks that arise in connection with digital nomadism. It is determined that one of the most characteristic features of a modern person is hypermobility eparkourism. In addition the paper describes the problems of anonymity in virtual space and the emergence of systems that provide anonymity of the individual as well as the risks arising in connection with that. The problem of lack of culture and value systems in the virtual space is highlighted as well the problem of developing contradictions in information leading to the alienation of people from the real world. It was determined that the informatization of economy on the one hand leads to faster business processes reduced transaction costs saving of variable costs due to robotization of production and on the other hand it leads to the transformation of competition growth of tension in society in connection with the job cuts. Another problem is personal and national security associated with the development of social networks the developers of which are other countries and also with the emergence of mechanisms of influence on mass consciousness. Scientific novelty it is shown that the risks

Digital voltage discriminator

International Nuclear Information System (INIS)

Zhou Zhicheng

1992-01-01

A digital voltage discriminator is described, which is synthesized by digital comparator and ADC. The threshold is program controllable with high stability. Digital region of confusion is approximately equal to 1.5 LSB. This discriminator has a single channel analyzer function model with channel width of 1.5 LSB

Analog-to-digital conversion

CERN Document Server

Pelgrom, Marcel J M

2010-01-01

The design of an analog-to-digital converter or digital-to-analog converter is one of the most fascinating tasks in micro-electronics. In a converter the analog world with all its intricacies meets the realm of the formal digital abstraction. Both disciplines must be understood for an optimum conversion solution. In a converter also system challenges meet technology opportunities. Modern systems rely on analog-to-digital converters as an essential part of the complex chain to access the physical world. And processors need the ultimate performance of digital-to-analog converters to present the results of their complex algorithms. The same progress in CMOS technology that enables these VLSI digital systems creates new challenges for analog-to-digital converters: lower signal swings, less power and variability issues. Last but not least, the analog-to-digital converter must follow the cost reduction trend. These changing boundary conditions require micro-electronics engineers to consider their design choices for...

Digital Broadband Content: Digital Content Strategies and policies. OECD Digital Economy Papers, No. 119

Science.gov (United States)

OECD Publishing (NJ1), 2006

2006-01-01

The development of digital content raises new issues as rapid technological developments challenge existing business models and government policies. This OECD study identifies and discusses six groups of business and public policy issues and illustrates these with existing and potential OECD Digital Content Strategies and Policies: (1) Innovation…

Spectrometric analog-to-digital converter

International Nuclear Information System (INIS)

Ormandzhiev, S.I.; Jordanov, V.T.

1988-01-01

Converter of digit-by-digit counterbalancing with slipping dial with number of channels equal to total number of states of the main digital-to-analog converter of digit-by-digit counterbalancing systems is presented. Algorithm for selection of digital-to-analog converters, which must be used by means of computer is suggested

Digital divide and digital opportunity: Comparison, analysis and strategies for sustainable development in developing nations

International Nuclear Information System (INIS)

Bhunia, C.T.; Onime, C.

2007-07-01

The world is witnessing a new digital economic order which may be quantified by the diffusion of information technology and globalization process. The current information technology gap (digital divide) between developed countries and developing countries is huge. Improvements in information technology (measured by the digital opportunity index) usually open up an opportunity for national/regional growth and development. There is a need for scientific investigation on the digital divide, digital opportunity index and their consequences. This paper presents a critical analysis of existing digital divide and its trends, it also investigates the relationship between the digital divide and the digital opportunity index. A mathematical model based on analysis of the growing digital divide is presented as a possible tool for combating and eradicate the digital divide gap which is only possible if developing and poor nations take advantage of the digital opportunities that can transform them into global competitive partners in digital knowledge economy. (author)

Digitalizing the welfare state: citizenship discourses in Danish digitalization strategies from 2002 to 2015

DEFF Research Database (Denmark)

Schou, Jannick; Hjelholt, Morten

2017-01-01

As governments worldwide become increasingly reliant on digital technologies and e-government, ‘digital citizenship’ has become an important topic for research and policy-makers alike. While often described as the contemporary ‘ideal’ of citizenship, research has tended to downplay the normative...... dimensions of digital citizenship. Counter to such depoliticized approaches, this article argues that the digital citizen is a deeply political figure. Through a discourse-theoretical analysis of Danish governmental digitalization strategies from 2002 to 2015, the article shows how these have relied...... and digital citizenship, the article challenges current views on digitalization. The article foregrounds how digitalization serves to reproduce and recast already-existing political rationalities and must be considered in relation to neoliberal hegemony....

MODELING AND ANALYSIS OF DYNAMICS IN BEARING SYSTEM OF DRILLING, MILLING AND BORING MACHINE WITH MONO-COLUMN

Directory of Open Access Journals (Sweden)

Yu. V. Vasilevich

2015-01-01

Full Text Available  FEM-analysis of dynamics in the bearing system of a heavy-duty machine tool has been carried out in the paper. This is a prospective variant for a large-size multi-purpose machine tool with a horizontal sliding ram. A saddle and a ram are moving vertically along a subtle mono-column. A rigid double-column is used in the existing analog machine tool. A static, modal and harmonic analysis of the bearing system with the mono-column has been made in the paper. It has been done with the help of FEM-simulation prior to fabrication of a prototype sample. Previously conducted calculations for the analog machine tool have shown good compatibility of FEM-calculation with experiments.Six common machine tool resonances have been revealed for the bearing system. Their oscillating cutting forces are actively exciting three-four resonance modes. Ranges of a flexure-torsion resonance (20–40 Hz and nose-diving resonances (70–90 Hz have been determined in the paper. The paper shows that the range of multi-wave resonances starts significantly higher from 140 Hz. These resonances are interconnected with bending oscillations of the ram and bucklings of the column walls which are matched with the oscillations. The paper demonstrates stability in resonance pattern. The torsional resonance of the column on the frequency of nearly 40 Hz is considered as the more dangerous one. Spindle rigidity goes down up to 3.8 Н/μm. It is possible to observe self-stabilization of the torsional resonance. Frequency of the torsional oscillations is practically unchangeable when there is a lifting or lowering down of the saddle and the ram. It is related to the migration of dynamical axis of torsion.Frequency-response characteristics of the bearing system have been constructed for various saddle positions on the column. Three frequency intervals that make it possible to carry out machining operation have been determined in the paper. The first interval is a static one. The

Digital positron annihilation spectrometer

International Nuclear Information System (INIS)

Cheng Bin; Weng Huimin; Han Rongdian; Ye Bangjiao

2010-01-01

With the high speed development of digital signal process, the technique of the digitization and processing of signals was applied in the domain of a broad class of nuclear technique. The development of digital positron lifetime spectrometer (DPLS) is more promising than the conventional positron lifetime spectrometer equipped with nuclear instrument modules. And digital lifetime spectrometer has many advantages, such as low noise, long term stability, flexible online or offline digital processing, simple setup, low expense, easy to setting, and more physical information. Digital constant fraction discrimination is for timing. And a new method of optimizing energy windows setting for digital positron lifetime spectrometer is also developed employing the simulated annealing for the convenient use. The time resolution is 220ps and the count rate is 200cps. (authors)

Preservation in the Age of Google: Digitization, Digital Preservation, and Dilemmas

Science.gov (United States)

Conway, Paul

2010-01-01

The cultural heritage preservation community now functions largely within the environment of digital technologies. This article begins by juxtaposing definitions of the terms "digitization for preservation" and "digital preservation" within a sociotechnical environment for which Google serves as a relevant metaphor. It then reviews two reports…

Could digital imaging be an alternative for digital colorimeters?

Science.gov (United States)

Caglar, Alper; Yamanel, Kivanc; Gulsahi, Kamran; Bagis, Bora; Ozcan, Mutlu

2010-12-01

This study evaluated the colour parameters of composite and ceramic shade guides determined using a colorimeter and digital imaging method with illuminants at different colour temperatures. Two different resin composite shade guides, namely Charisma (Heraeus Kulzer) and Premise (Kerr Corporation), and two different ceramic shade guides, Vita Lumin Vacuum (VITA Zahnfabrik) and Noritake (Noritake Co.), were evaluated at three different colour temperatures (2,700 K, 2,700-6,500 K, and 6500 K) of illuminants. Ten shade tabs were selected (A1, A2, A3, A3,5, A4, B1, B2, B3, C2 and C3) from each shade guide. CIE Lab values were obtained using digital imaging and a colorimeter (ShadeEye NCC Dental Chroma Meter, Shofu Inc.). The data were analysed using two-way ANOVA, and Pearson's correlation. While mean L* values of both composite and ceramic shade guides were not affected from the colour temperature, L* values obtained with the colorimeter showed significantly lower values than those of the digital imaging (p colorimeter and digital imaging did not show significant differences (p > 0.05). For both composite and ceramic shade guides, L* and b* values obtained from colorimeter and digital imaging method presented a high level of correlation. High-level correlations were also acquired for a* values in all shade guides except for the Charisma composite shade guide. Digital imaging method could be an alternative for the colorimeters unless the proper object-camera distance, digital camera settings and suitable illumination conditions could be supplied. However, variations in shade guides, especially for composites, may affect the correlation.

An Assessment of Elemental Compositions and Concentrations in a Marble Sample from Hatnub Area using Internal Mono Standard Neutron Activation Analysis

International Nuclear Information System (INIS)

Soliman, N.F.; EL-Shershaby, A.; EL-Bahi, S.; Walley El-Dine, N.; Abd El-Halim, E.S.; Afifi, S.

2012-01-01

A marble sample was taken from Hatnub area near Asyot, where a high pollution is expected. The sample was specially treated and prepared for elemental analysis using the k 0 -based internal mono standard neutron activation analysis . The irradiation facility of the first Egyptian Training Research Reactor (ETRR-1) was used to irradiate the sample together with gold and zirconium monitor samples. The pneumatic irradiation rabbit system (PIRS) built in the vertical thermal column of the second Egyptian Training Research Reactor (ETRR-2) was used to irradiate another weight of the marble sample and a sample from a certificated reference material JB-1 for short time irradiation. A new method was developed to measure the thermal to epithermal neutron flux ratio and the deviation in the real epithermal neutron spectrum ( 1/E 1±a lpha ) from the ideal (1/E ). The elemental analysis was carried out by high-resolution gamma-ray spectrometry. The accuracy of the internal mono standard method has been evaluated by analyzing the JB-1 certified reference material

Digital Simulation in the Geosciences

Directory of Open Access Journals (Sweden)

Alexandr A. Lobanov

2014-09-01

Full Text Available This article provides an analysis of methods for digital modeling in the area of Earth Sciences. The author illustrates the difference between digital modeling in radio communication and that in the area of Earth Sciences. The article examines the integration aspect of digital models, demonstrates the advantages of digital over analog models, and illustrates that digital models are discrete. The author outlines the characteristics of digital modeling and illustrates the logical structure of digital models.

Integration technique of digital I and C replacement and its Critical Digital Review procedure

International Nuclear Information System (INIS)

Huang, Hui-Wen; Yang, Wen-Long

2013-01-01

Highlights: ► A digital I and C replacement integration technique have been developed. ► Establishment of Nuclear Power Plant Digital Replacement Integration Guideline. ► Preliminary Investigation on I and C System Digitalization. ► Evaluation on I and C System Digitalization. ► Establishment of I and C System Digitalization Architectures. -- Abstract: Institute of Nuclear Energy Research (INER) developed a digital Instrumentation and Control (I and C) replacement integration technique on the basis of requirement of the three existing nuclear power plants (NPPs), which are Chin–Shan (CS) NPP, Kuo–Sheng (KS) NPP, and Maanshan (MS) NPP, in Taiwan, and also developed the related Critical Digital Review (CDR) procedure. The digital I and C replacement integration technique includes: (1) Establishment of Nuclear Power Plant Digital Replacement Integration Guideline, (2) Preliminary Investigation on I and C System Digitalization, (3) Evaluation on I and C System Digitalization, and (4) Establishment of I and C System Digitalization Architectures. These works can be a reference for performing I and C system digital replacement integration of the three existing NPPs of Taiwan Power Company (TPC). A CDR is the review for a critical system digital I and C replacement. The major reference of this procedure is EPRI TR-1011710 (2005) “Handbook for Evaluating Critical Digital Equipment and Systems” which was published by the Electric Power Research Institute (EPRI). With this document, INER developed a TPC-specific CDR procedure. Currently, CDR becomes one of the policies for digital I and C replacement in TPC. The contents of this CDR procedure include: Scope, Responsibility, Operation Procedure, Operation Flow Chart, CDR review items. The CDR review items include the comparison of the design change, Software Verification and Validation (SV and V), Failure Mode and Effects Analysis (FMEA), Evaluation of Diversity and Defense-in-depth (D3), Evaluation of

Digital evidence

Directory of Open Access Journals (Sweden)

Lukić Tatjana

2012-01-01

Full Text Available Although computer makes human activities faster and easier, innovating and creating new forms of work and other kinds of activities, it also influenced the criminal activity. The development of information technology directly affects the development of computer forensics without which, it can not even imagine the discovering and proving the computer offences and apprehending the perpetrator. Information technology and computer forensic allows us to detect and prove the crimes committed by computer and capture the perpetrators. Computer forensics is a type of forensics which can be defined as a process of collecting, preserving, analyzing and presenting digital evidence in court proceedings. Bearing in mind, that combat against crime, in which computers appear as an asset or object of the offense, requires knowledge of digital evidence as well as specific rules and procedures, the author in this article specifically addresses the issues of digital evidence, forensic (computer investigation, specific rules and procedures for detecting, fixing and collecting digital evidence and use of this type of evidence in criminal proceedings. The author also delas with international standards regarding digital evidence and cyber-space investigation.

Film-screen digital radiography

International Nuclear Information System (INIS)

Schwenker, R.P.; Eger, H.

1985-01-01

The excellent performance of the digital film-screen system as a receptor for projection radiographic data is discussed. An experimental system for obtaining high quality digital radiographic data by laser scanning radiographic films is described. This system is being used to evaluate the clinical utility of various digital image processing algorithms. Future plans include an investigation of quantitative analysis of projection radiographic data. Digital data obtained by film scanning can be used with digital image archiving and communications systems. (author)

Digital preservation for heritages

CERN Document Server

Lu, Dongming

2011-01-01

""Digital Preservation for Heritages: Technologies and Applications"" provides a comprehensive and up-to-date coverage of digital technologies in the area of cultural heritage preservation, including digitalization, research aiding, conservation aiding, digital exhibition, and digital utilization. Processes, technical frameworks, key technologies, as well as typical systems and applications are discussed in the book. It is intended for researchers and students in the fields of computer science and technology, museology, and archaeology. Dr. Dongming Lu is a professor at College of Computer Sci

Digital Leadership

DEFF Research Database (Denmark)

Zupancic, Tadeja; Verbeke, Johan; Achten, Henri

2016-01-01

Leadership is an important quality in organisations. Leadership is needed to introduce change and innovation. In our opinion, in architectural and design practices, the role of leadership has not yet been sufficiently studied, especially when it comes to the role of digital tools and media....... With this paper we intend to initiate a discussion in the eCAADe community to reflect and develop ideas in order to develop digital leadership skills amongst the membership. This paper introduces some important aspects, which may be valuable to look into when developing digital leadership skills....

Becoming digital

DEFF Research Database (Denmark)

Pors, Anja Svejgaard

2015-01-01

. An ethnographic account of how digital reforms are implemented in practice shows how street-level bureaucrat’s classic tasks such as specialized casework are being reconfigured into educational tasks that promote the idea of “becoming digital”. In the paper, the author argues that the work of “becoming digital....... Originality/value: The study contributes to ethnographic research in public administration by combining two separate subfields, e-government and street-level bureaucracy, to discern recent transformations in public service delivery. In the digital era, tasks, control and equality are distributed in ways...

Digital Humanities

DEFF Research Database (Denmark)

Brügger, Niels

2016-01-01

, and preserving material to study, as an object of study in its own right, as an analytical tool, or for collaborating, and for disseminating results. The term "digital humanities" was coined around 2001, and gained currency within academia in the following years. However, computers had been used within......Digital humanities is an umbrella term for theories, methodologies, and practices related to humanities scholarship that use the digital computer as an integrated and essential part of its research and teaching activities. The computer can be used for establishing, finding, collecting...

Are "Digital Natives" Really Digitally Competent?--A Study on Chinese Teenagers

Science.gov (United States)

Li, Yan; Ranieri, Maria

2010-01-01

Literature review has found that despite the considerable attention focused on "digital natives", few studies have carefully investigated the characteristics of this group. The purpose of this study is to contribute to the debate on digital natives by providing a "piece of evidence" on the digital competence status of a group…

How Digital Are the Digital Humanities? An Analysis of Two Scholarly Blogging Platforms

Science.gov (United States)

Puschmann, Cornelius; Bastos, Marco

2015-01-01

In this paper we compare two academic networking platforms, HASTAC and Hypotheses, to show the distinct ways in which they serve specific communities in the Digital Humanities (DH) in different national and disciplinary contexts. After providing background information on both platforms, we apply co-word analysis and topic modeling to show thematic similarities and differences between the two sites, focusing particularly on how they frame DH as a new paradigm in humanities research. We encounter a much higher ratio of posts using humanities-related terms compared to their digital counterparts, suggesting a one-way dependency of digital humanities-related terms on the corresponding unprefixed labels. The results also show that the terms digital archive, digital literacy, and digital pedagogy are relatively independent from the respective unprefixed terms, and that digital publishing, digital libraries, and digital media show considerable cross-pollination between the specialization and the general noun. The topic modeling reproduces these findings and reveals further differences between the two platforms. Our findings also indicate local differences in how the emerging field of DH is conceptualized and show dynamic topical shifts inside these respective contexts. PMID:25675441

Anatomía Cerebral del mono araña Ateles geoffroyi estudiada utilizando imágenes de resonancia magnética. Primer reporte: estudio comparativo con el cerebro humano Homo Sapiens

OpenAIRE

Chico-Ponce de León, Fernando; Platas-Neri, Diana; Muñoz-Delgado, Jairo; Santillán-Doherty, Ana-María; Arenas-Rosas, Rita; Trejo, David; Conde, Rubén; Ojeda-Flores, Rafael; Campos-Romo, Aurelio; Castro-Sierra, Eduardo; Cervantes, Juan José; Braun, Marc

2010-01-01

El objetivo del presente estudio cualitativo fue analizar los aspectos morfológicos de la anatomía cerebral interna utilizando imágenes de resonancia magnética (IRM) en dos especies de primates, El mono Araña (A. geoffroyi) y el humano (H. sapiens), tomando como base un estudio comparativo de las estructuras cerebrales de las dos especies, concentrándose primordialmente en el sistema límbico del cerebro del mono araña. Aunque es una especie común en el hemisferio occidental, es interesante pa...

Digital TMI

Science.gov (United States)

Rios, Joseph

2012-01-01

Presenting the current status of the Digital TMI project to visiting members of the FAA Command Center. Digital TMI is an effort to store national-level traffic management initiatives in a standards-compliant manner. Work is funded by the FAA.

Public Access to Digital Material; A Call to Researchers: Digital Libraries Need Collaboration across Disciplines; Greenstone: Open-Source Digital Library Software; Retrieval Issues for the Colorado Digitization Project's Heritage Database; Report on the 5th European Conference on Digital Libraries, ECDL 2001; Report on the First Joint Conference on Digital Libraries.

Science.gov (United States)

Kahle, Brewster; Prelinger, Rick; Jackson, Mary E.; Boyack, Kevin W.; Wylie, Brian N.; Davidson, George S.; Witten, Ian H.; Bainbridge, David; Boddie, Stefan J.; Garrison, William A.; Cunningham, Sally Jo; Borgman, Christine L.; Hessel, Heather

2001-01-01

These six articles discuss various issues relating to digital libraries. Highlights include public access to digital materials; intellectual property concerns; the need for collaboration across disciplines; Greenstone software for construction and presentation of digital information collections; the Colorado Digitization Project; and conferences…

Online Tribes and Digital Authority: What Can Social Theory Bring to Digital Archaeology?

Directory of Open Access Journals (Sweden)

Richardson Lorna-Jane

2017-01-01

Full Text Available From early discussions of the disruptive potential of computer technologies for archaeological applications, to the present era of digital archaeology as the technical underpinning of modern archaeological practice, we have continued to debate the potential impacts of digital communication and digital capture and storage on our knowledge, profession and communications. The increased use of digital tools and methods for archaeological research and dissemination, as well as what Roosevelt (2015 has referred to as the shift to the digital paradigm within archaeological practice, leads us to suggest that the impact of this paradigm shift requires careful and critical examination. This article will examine the edges of the disciplines of archaeology and sociology, where we aim to advance our understanding of the relationship between digital technologies and archaeological knowledge from a uniquely social perspective, using the theoretical approaches of both classic and modern sociologists. The application of this lens of sociology to digital archaeology equips us to understand how archaeology and archaeological practice is situated in a social world, which is especially relevant in the Global West, where digital technology is ubiquitous. Through a critical consideration of the complexity of use of digital technologies within digital archaeology, we can begin to shift our focus away from the character and method of tools and workflow, to the background of intellectual power and influence.

Dual beam vidicon digitizer

International Nuclear Information System (INIS)

Evans, T.L.

1976-01-01

A vidicon waveform digitizer which can simultaneously digitize two independent signals has been developed. Either transient or repetitive waveforms can be digitized with this system. A dual beam oscilloscope is used as the signal input device. The light from the oscilloscope traces is optically coupled to a television camera, where the signals are temporarily stored prior to digitizing

Pd(II)-Catalyzed Hydroxyl-Directed C–H Olefination Enabled by Mono-Protected Amino Acid Ligands

Science.gov (United States)

Lu, Yi; Wang, Dong-Hui; Engle, Keary M.

2010-01-01

A novel Pd(II)-catalyzed ortho-C–H olefination protocol has been developed using spatially remote, unprotected tertiary, secondary, and primary alcohols as the directing groups. Mono-N-protected amino acid ligands were found to promote the reaction, and an array of olefin coupling partners could be used. When electron-deficient alkenes were used, the resulting olefinated intermediates underwent subsequent Pd(II)-catalyzed oxidative intramolecular cyclization to give the corresponding pyran products, which could be converted into ortho-alkylated alcohols under hydrogenolysis conditions. The mechanistic details of the oxidative cyclization step are discussed and situated in the context of the overall catalytic cycle. PMID:20359184

Measuring digit lengths with 3D digital stereophotogrammetry: A comparison across methods.

Science.gov (United States)

Gremba, Allison; Weinberg, Seth M

2018-05-09

We compared digital 3D stereophotogrammetry to more traditional measurement methods (direct anthropometry and 2D scanning) to capture digit lengths and ratios. The length of the second and fourth digits was measured by each method and the second-to-fourth ratio was calculated. For each digit measurement, intraobserver agreement was calculated for each of the three collection methods. Further, measurements from the three methods were compared directly to one another. Agreement statistics included the intraclass correlation coefficient (ICC) and technical error of measurement (TEM). Intraobserver agreement statistics for the digit length measurements were high for all three methods; ICC values exceeded 0.97 and TEM values were below 1 mm. For digit ratio, intraobserver agreement was also acceptable for all methods, with direct anthropometry exhibiting lower agreement (ICC = 0.87) compared to indirect methods. For the comparison across methods, the overall agreement was high for digit length measurements (ICC values ranging from 0.93 to 0.98; TEM values below 2 mm). For digit ratios, high agreement was observed between the two indirect methods (ICC = 0.93), whereas indirect methods showed lower agreement when compared to direct anthropometry (ICC < 0.75). Digit measurements and derived ratios from 3D stereophotogrammetry showed high intraobserver agreement (similar to more traditional methods) suggesting that landmarks could be placed reliably on 3D hand surface images. While digit length measurements were found to be comparable across all three methods, ratios derived from direct anthropometry tended to be higher than those calculated indirectly from 2D or 3D images. © 2018 Wiley Periodicals, Inc.

Radiologists' preferences for digital mammographic display. The International Digital Mammography Development Group.

Science.gov (United States)

Pisano, E D; Cole, E B; Major, S; Zong, S; Hemminger, B M; Muller, K E; Johnston, R E; Walsh, R; Conant, E; Fajardo, L L; Feig, S A; Nishikawa, R M; Yaffe, M J; Williams, M B; Aylward, S R

2000-09-01

To determine the preferences of radiologists among eight different image processing algorithms applied to digital mammograms obtained for screening and diagnostic imaging tasks. Twenty-eight images representing histologically proved masses or calcifications were obtained by using three clinically available digital mammographic units. Images were processed and printed on film by using manual intensity windowing, histogram-based intensity windowing, mixture model intensity windowing, peripheral equalization, multiscale image contrast amplification (MUSICA), contrast-limited adaptive histogram equalization, Trex processing, and unsharp masking. Twelve radiologists compared the processed digital images with screen-film mammograms obtained in the same patient for breast cancer screening and breast lesion diagnosis. For the screening task, screen-film mammograms were preferred to all digital presentations, but the acceptability of images processed with Trex and MUSICA algorithms were not significantly different. All printed digital images were preferred to screen-film radiographs in the diagnosis of masses; mammograms processed with unsharp masking were significantly preferred. For the diagnosis of calcifications, no processed digital mammogram was preferred to screen-film mammograms. When digital mammograms were preferred to screen-film mammograms, radiologists selected different digital processing algorithms for each of three mammographic reading tasks and for different lesion types. Soft-copy display will eventually allow radiologists to select among these options more easily.

Obtention of Samarium and Gadolinium concentrates by solvent extraction using mono-2-ethylhexyl ester of 2-ethylhexyl phosphonic acid; Obtencao de concentrados de samario e gadolinio via extracao por solventes com o ester mono-2-etilhexil do acido 2-etilhexilfosfonico

Energy Technology Data Exchange (ETDEWEB)

Miranda, Junior, Pedro

1996-07-01

The rare earth chlorides solution employed in this study, which is constituted by medium and heavy fractions, is derived from monazite processing accomplished by NUCLEMON-Mineroquimica (SP). This solution shows an acidity about 1.18 M and 189 g/L of rare earth oxides, containing as main constituents: Sm(34.55%), Gd(23.85%), Dy (6.82%), and Y (24.45%). It was used, as organic phase, 2-ethylhexyl phosphonic acid, mono-2-ethylhexylester diluted to 1 M in isododecane. (author)

Mono- and Di-Alkylation Processes of DNA Bases by Nitrogen Mustard Mechlorethamine.

Science.gov (United States)

Larrañaga, Olatz; de Cózar, Abel; Cossío, Fernando P

2017-12-06

The reactivity of nitrogen mustard mechlorethamine (mec) with purine bases towards formation of mono- (G-mec and A-mec) and dialkylated (AA-mec, GG-mec and AG-mec) adducts has been studied using density functional theory (DFT). To gain a complete overview of DNA-alkylation processes, direct chloride substitution and formation through activated aziridinium species were considered as possible reaction paths for adduct formation. Our results confirm that DNA alkylation by mec occurs via aziridine intermediates instead of direct substitution. Consideration of explicit water molecules in conjunction with polarizable continuum model (PCM) was shown as an adequate computational method for a proper representation of the system. Moreover, Runge-Kutta numerical kinetic simulations including the possible bisadducts have been performed. These simulations predicted a product ratio of 83:17 of GG-mec and AG-mec diadducts, respectively. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Endospores of B subtilis are pyrogenic and activate Mono Mac 6 cells

DEFF Research Database (Denmark)

Moesby, Lise; Hansen, Erik W; Christensen, Jens D

2003-01-01

interleukin-6. Lipopolysaccharides (LPS) dose-dependently induce interleukin-6 release, but the curve differs from that of LTA both in shape and offset. The interleukin-6 secretion induced by LPS, LTA and B. subtilis bacteria can be blocked by 73-85% by an antibody directed against CD14, whereas the antibody......The monocytic cell line Mono Mac 6 is sensitive to pyrogens and interleukin-6 secretion is induced after exposure to pyrogens. The aim of this study is to examine the pyrogenic activity and the interleukin-6-inducing capacity of the Gram-positive B. subtilis bacteria, endospores and isolated cell...... in a sandwich immunoassay. B. subtilis bacteria and endospores induce interleukin-6 in a dose-dependent manner. Endospores are less potent than bacteria. Lipoteichoic acid (LTA) isolated from B. subtilis induces interleukin-6 in a dose-dependent manner, whereas muramyl dipeptide (MDP) is unable to induce...

Digital Audiobooks

DEFF Research Database (Denmark)

Have, Iben; Pedersen, Birgitte Stougaard

Audiobooks are rapidly gaining popularity with widely accessible digital downloading and streaming services. The paper is framing how the digital audiobook expands and changes the target groups for book publications and how it as an everyday activity is creating new reading experiences, places...

Applying corrections to digitized data while digitizing magnetic chart

Digital Repository Service at National Institute of Oceanography (India)

Suresh, T.

data could be time consuming during online digitizing operation. Secondly, this could be more error prone if proper error detection and correction methods are not em- ployed. Here a simpler method is illustrated which has been used for digitizing...

76 FR 11680 - Digital Low Power Television, Television Translator, and Television Booster Stations and Digital...

Science.gov (United States)

2011-03-03

...] Digital Low Power Television, Television Translator, and Television Booster Stations and Digital Class A... Commission's Rules to Establish Rules for Digital Low Power, Television Translator, and Television Booster... Digital Low Power Television Translator, Television Booster Stations, and to Amend Rules for Digital Class...

Digital fabrication

CERN Document Server

2012-01-01

The Winter 2012 (vol. 14 no. 3) issue of the Nexus Network Journal features seven original papers dedicated to the theme “Digital Fabrication”. Digital fabrication is changing architecture in fundamental ways in every phase, from concept to artifact. Projects growing out of research in digital fabrication are dependent on software that is entirely surface-oriented in its underlying mathematics. Decisions made during design, prototyping, fabrication and assembly rely on codes, scripts, parameters, operating systems and software, creating the need for teams with multidisciplinary expertise and different skills, from IT to architecture, design, material engineering, and mathematics, among others The papers grew out of a Lisbon symposium hosted by the ISCTE-Instituto Universitario de Lisboa entitled “Digital Fabrication – A State of the Art”. The issue is completed with four other research papers which address different mathematical instruments applied to architecture, including geometric tracing system...

Digital Relationships

DEFF Research Database (Denmark)

Ledborg Hansen, Richard

-­rich information and highly interesting communication are sky-­high and rising. With a continuous increase in digitized communication follows a decrease in face-­to-­face encounters and our ability to engage in inter-­personal relationships are suffering for it (Davis, 2013). The behavior described in this paper......-­‐Jones, 2011) for increases in effectiveness and efficiency we indiscriminately embrace digital communication and digitized information dissemination with enthusiasm – at the risk of ignoring the potentially dark side of technology. However, technology also holds a promise for better understanding precisely...... for the same reasons – that the growing amount of digitized communication “out there” represents data waiting to be sifted, analyzed and decoded. In this paper “Facebook behavior” refers to a particular behavior characterized by presenting your self and representations of selected self in the hope of getting...

Modulation stability and dispersive optical soliton solutions of higher order nonlinear Schrödinger equation and its applications in mono-mode optical fibers

Science.gov (United States)

Arshad, Muhammad; Seadawy, Aly R.; Lu, Dianchen

2018-01-01

In mono-mode optical fibers, the higher order non-linear Schrödinger equation (NLSE) describes the propagation of enormously short light pulses. We constructed optical solitons and, solitary wave solutions of higher order NLSE mono-mode optical fibers via employing modified extended mapping method which has important applications in Mathematics and physics. Furthermore, the formation conditions are also given on parameters in which optical bright and dark solitons can exist for this media. The moment of the obtained solutions are also given graphically, that helps to realize the physical phenomena's of this model. The modulation instability analysis is utilized to discuss the model stability, which verifies that all obtained solutions are exact and stable. Many other such types of models arising in applied sciences can also be solved by this reliable, powerful and effective method. The method can also be functional to other sorts of higher order nonlinear problems in contemporary areas of research.

Poly(mono/diethylene glycol n-tetradecyl ether vinyl ethers with Various Molecular Weights as Phase Change Materials

Directory of Open Access Journals (Sweden)

Dongfang Pei

2018-02-01

Full Text Available At present, research on the relationship of comb-like polymer phase change material structures and their heat storage performance is scarce. Therefore, this relationship from both micro and macro perspectives will be studied in this paper. In order to achieve a high phase change enthalpy, ethylene glycol segments were introduced between the vinyl and the alkyl side chains. A series of poly(mono/diethylene glycol n-tetradecyl ether vinyl ethers (PC14EnVEs (n = 1, 2 with various molecular weights were polymerized by living cationic polymerization. The results of PC14E1VE and PC14E2VE showed that the minimum number of carbon atoms required for side-chain crystallization were 7.7 and 7.2, which were lower than that reported in the literature. The phase change enthalpy 89 J/g (for poly(mono ethylene glycol n-tetradecyl ether vinyl ethers and 86 J/g (for poly(hexadecyl acrylate were approximately equal. With the increase of molecular weight, the melting temperature, the melting enthalpy, and the initial thermal decomposition temperature of PC14E1VE changed from 27.0 to 28.0 °C, from 95 to 89 J/g, and from 264 to 287 °C, respectively. When the number average molar mass of PC14EnVEs exceeded 20,000, the enthalpy values remained basically unchanged. The introduction of the ethylene glycol chain was conducive to the crystallization of alkyl side chains.

STRATEGI PEMASARAN PRODUK DIGITAL PRINTING PADA CV. FNB DIGITAL JAMBI

OpenAIRE

Yuniarti, Yenni; Mauliana, Sarah

2012-01-01

CV. Digital FNB is one of the companies that involved in Digital Printing business. Based on survey in the middle of 2011-2012, there are 31 digital printing businesses in the city of Jambi. In order to examine the marketing stratey implemented, descriptive study has been conducted, uses interview, observation, and documentation as instruments. The strategy that observed in this study consist of marketing strategy including market segmentation, targeting, product strategy, pricing strategy, ...

Digital Language Death

Science.gov (United States)

Kornai, András

2013-01-01

Of the approximately 7,000 languages spoken today, some 2,500 are generally considered endangered. Here we argue that this consensus figure vastly underestimates the danger of digital language death, in that less than 5% of all languages can still ascend to the digital realm. We present evidence of a massive die-off caused by the digital divide. PMID:24167559

Digital language death.

Directory of Open Access Journals (Sweden)

András Kornai

Full Text Available Of the approximately 7,000 languages spoken today, some 2,500 are generally considered endangered. Here we argue that this consensus figure vastly underestimates the danger of digital language death, in that less than 5% of all languages can still ascend to the digital realm. We present evidence of a massive die-off caused by the digital divide.

La radio digital

Directory of Open Access Journals (Sweden)

Carlos Eduardo Cortés S.

2015-01-01

Full Text Available La radio digital es un producto de la llamada convergencia digital. Las nuevas tecnologías interconectadas permiten la aparición de nuevos modos de audiencia y la implementación de herramientas versátiles. Habla del problema de los estándares, de la radio satelital, la radio digital terrestre, las radios internacionales, la interactividad.

Effects of a mixture of non-ortho- and mono-ortho-polychlorinated biphenyls on reproduction in Fundulus heteroclitus (Linnaeus)

Energy Technology Data Exchange (ETDEWEB)

Black, D.E.; Gutjahr-Gobell, R.; Pruell, R.J.; Bergen, B. [Environmental Protection Agency, Narragansett, RI (United States); McElroy, A.E. [State Univ. of New York, Stony Brook, NY (United States). Marine Sciences Research Center

1998-07-01

To assess the effects of polychlorinated biphenyls (PCBs) on reproduction, female Fundulus heteroclitus were exposed to a mixture of non-ortho- and mono-ortho-PCBs, mimicking the mixture found in fish collected from New Bedford Harbor, Massachusetts, USA, a PCB-contaminated estuary. Exposure was by intraperitoneal injection of the mixture dissolved in corn oil. Doses of 0.76, 3.8, and 19 {micro}g PCB mixture per gram of wet weight produced liver concentrations of 2.99, 12.2, and 32.8 {micro}g non-ortho- and mono-ortho-PCBs per gram of dry liver, with dioxin toxic equivalency concentrations (TEQs) of 0.0963, 0.409, and 0.720 ng/g, respectively. Female mortality was 58%, and egg production was reduced by 77% at the highest dose, compared to controls. Food consumption declined with increasing PCB concentration, suggesting that PCBs act indirectly to reduce fecundity through an energetic effect. Pituitary gonadotropin content appeared to be suppressed at the highest dose, but the ability of ovarian follicles to produce estradiol and testosterone in vitro was not impaired. Significant residue-effects linkages were found, with TEQ emerging as a potential indicator of adverse effects. Mortality was directly related, and egg production was inversely related to log{sub 10}TEQ. Multiple regression analysis indicated that egg production was directly related to pituitary gonadotropin content and food consumption.

New techniques in digital holography

CERN Document Server

Picart, Pascal

2015-01-01

A state of the art presentation of important advances in the field of digital holography, detailing advances related to fundamentals of digital holography, in-line holography applied to fluid mechanics, digital color holography, digital holographic microscopy, infrared holography, special techniques in full field vibrometry and inverse problems in digital holography

VELOCIRAPTOR: An X-band photoinjector and linear accelerator for the production of Mono-Energetic {gamma}-rays

Energy Technology Data Exchange (ETDEWEB)

Anderson, S.G., E-mail: anderson131@llnl.gov [Lawrence Livermore National Laboratory, 7000 East Ave., Livermore, CA 94551 (United States); Albert, F.; Bayramian, A.J.; Beer, G.; Bonanno, R.E.; Cross, R.R.; Deis, G.; Ebbers, C.A.; Gibson, D.J.; Hartemann, F.V.; Houck, T.L.; Marsh, R.A.; McNabb, D.P.; Messerly, M.J.; Scarpetti, R.D.; Shverdin, M.Y.; Siders, C.W.; Wu, S.S.; Barty, C.P.J. [Lawrence Livermore National Laboratory, 7000 East Ave., Livermore, CA 94551 (United States); Adolphsen, C.E. [SLAC National Accelerator Laboratory, 2575 Sand Hill Rd., Menlo Park, CA 94025 (United States); and others

2011-11-21

The rf photoinjector and linear accelerator in the Mono-Energetic Gamma-ray (MEGa-ray) facility at LLNL is presented. This machine uses 11.4 GHz rf technology to accelerate a high-brightness electron beam up to 250 MeV to produce MeV {gamma}-rays through Compton scattering with a Joule-class laser pulse. Compton scattering-based generation of high flux, narrow bandwidth {gamma}-rays places stringent requirements on the performance of the accelerator. The component parts of the accelerator are presented and their requirements described. Simulations of expected electron beam parameters and the resulting light source properties are presented.

STABILITY OF EMULSIFIER-FREE EMULSION COPOLYMERIZATION OF METHYL METHACRYLATE/ BUTYL ACRYLATE/SODIUM MONO(ETHYL POLYOXYETHYLENE) MALEATE

Institute of Scientific and Technical Information of China (English)

Mao-gen Zhang; Zhi-xue Weng; Zhi-ming Huang; Zu-ren Pan

1999-01-01

A series of new water-soluble bifunctional comonomers having both carboxyl and alkyl polyoxyethylene groups, such as sodium mono(ethyl polyoxyethylene) maleate (ZE series) with various molecular weights of polyoxyethylene ethyl ether, were synthesized and characterized. The effects of the structural factor, the amount and feeding mode of the comonomers, the initiator concentration and polymerization temperature on the stability of emulsifier-free emulsion copolymerization of methyl methacrylate (MMA) and butyl acrylate (BA) in the presence of a small amount of ZE with potassium persulfate as initiator were investigated. Stable, almost monodispersed MMA/BA/ZE emulsifier-free latex particles were prepared.

Primary studies of trace quantities of green vegetation in Mono Lake area using 1990 AVIRIS data

Science.gov (United States)

Chen, Zhi-Kang; Elvidge, Chris D.; Groeneveld, David P.

1992-01-01

Our primary results in Jasper Ridge Biological Preserve indicate that high spectral resolution Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) data may provide a substantial advantage in vegetation, based on the chlorophyll red edge feature from 700-780 nm. The chlorophyll red edge was detected for green vegetation cover as low as 4.8 percent. The objective of our studies in Mono Lake area is to continue the experiments performed in Jasper Ridge and to examine the persistence of red edge feature of trace quantities of green vegetation for different plant communities with non-uniform soil backgrounds.

Digital radiography

International Nuclear Information System (INIS)

Zani, M.L.

2002-01-01

X-ray radiography is a very common technique used to check the homogeneity of a material or the inside of a mechanical part. Generally the radiation that goes through the material to check, produced an image on a sensitized film. This method requires time because the film needs to be developed, digital radiography has no longer this inconvenient. In digital radiography the film is replaced by digital data and can be processed as any computer file. This new technique is promising but its main inconvenient is that today its resolution is not so good as that of film radiography. (A.C.)

Digital radiography

International Nuclear Information System (INIS)

Kusano, Shoichi

1993-01-01

Firstly, from an historic point of view, fundamental concepts on digital imaging were reviewed to provide a foundation for discussion of digital radiography. Secondly, this review summarized the results of ongoing research in computed radiography that replaces the conventional film-screen system with a photo-stimulable phosphor plate; and thirdly, image quality, radiation protection, and image processing techniques were discussed with emphasis on picture archiving and communication system environment as our final goal. Finally, future expansion of digital radiography was described based on the present utilization of computed tomography at the National Defense Medical College Hospital. (author) 60 refs

Digital front-end module (DFEM) series; Digital front end module (DFEM) series

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

The digital front-end module (DFEM) is a module in which the processes ranging from the reception of digitally modulated radiofrequencies to the output of digital IF (Intermediate Frequency) signals or data streams are integrated. Beginning with a module for the MCNS (Multimedia Cable Network System) cable modem which was the first module in this business field approved by the Cable Labs, U.S., Toshiba has developed a series of DFEMs for various digital media for satellites, ground waves, and CATV (Cable Television) systems. The series is characterized by (1) the serialization of DFEMs compatible with various digital modulation techniques such as 8 PSK (Phase Shift Keying), OFDM (Orthogonal Frequency Division Multiplexing), and 256 QAM (Quadrature Amplitude Modulation), (2) easy connection with digital circuits thanks to the high shielding effect, and (3) the achievement of smaller size, higher performance, and lower power consumption. (translated by NEDO)

The synthesis of mono- and diacetyl-9H-fluorenes. Reactivity and selectivity in the Lewis acid catalyzed Friedel-Crafts acetylation of 9H-fluorene

DEFF Research Database (Denmark)

Titinchi, Salam J. J.; Kamounah, Fadhil S.; Abbo, Hanna S.

2008-01-01

Friedel-Crafts acetylation of 9H-fluorene is an effective route for the preparation of mono- and diacetyl-9H-fluorenes. Using acetylchloride as the reagent and aluminum chloride as the Lewis acid catalyst the effect of the solvent polarity, the temperature, the reaction time and the mode of addit......Friedel-Crafts acetylation of 9H-fluorene is an effective route for the preparation of mono- and diacetyl-9H-fluorenes. Using acetylchloride as the reagent and aluminum chloride as the Lewis acid catalyst the effect of the solvent polarity, the temperature, the reaction time and the mode......,7-diacetyl-9H-fluorene was obtained in 5-11 % yield when carbon disulfide was used as the solvent. Acetylation of 9H-fluorene in dichloroethane and carbon disulfide, using an excess of acetyl chloride and aluminum chloride at reflux temperature, gives 2,7-diacetyl-9H-fluorene exclusively in high yields (> 97...

Principles of synchronous digital hierarchy

CERN Document Server

Jain, Rajesh Kumar

2012-01-01

The book presents the current standards of digital multiplexing, called synchronous digital hierarchy, including analog multiplexing technologies. It is aimed at telecommunication professionals who want to develop an understanding of digital multiplexing and synchronous digital hierarchy in particular and the functioning of practical telecommunication systems in general. The text includes all relevant fundamentals and provides a handy reference for problem solving or defining operations and maintenance strategies. The author covers digital conversion and TDM principles, line coding and digital

Digitizing paper: the paradoxes of time in digital books

DEFF Research Database (Denmark)

Ebbesen, Toke Riis

In this paper I will analyze three contemporary danish examples of digital book distribution formats in terms of how they are designed with special attention to their use of time. Even though reading digital media in general are often framed in relation to time with notions such as the immediacy...... multiple times in the present, enmeshed in the digital books themselves or in their discourse. Either they look to the past through the use of nostalgia, retro, and appraisals of tradition (Baker, 2013), or to the future, through futuristic calls for renewal through radical design proposals, utopian...... of the present, compression of time (and space) (Virillio), and built-in oblivion(Augé, 1995), connected to moralizing notions of shallowness, restlessness and diseases such as stress (Carr, 2010). I will content, however, that the design of these digital formats – their typography, covers and external...

Search for Dark Matter in the mono-X final states (X = jets, Z, W, H) with ATLAS

CERN Document Server

Lo Sterzo, Francesco; The ATLAS collaboration

2018-01-01

Dark Matter searches in the ATLAS Experiment are perfomed analysing a wide number of experimental signatures. Among these, mono-X searches are a powerful tool since many models can be probed depending on the nature (jet, photon, vector boson, Higgs boson) of the Standard Model object which is used to identify and select the events. In this report a short introduction of the theoretical framweork is given, followed by three examples of different signatures that probe different theoretical models that describe an interaction between the Standard Model and Dark Matter.

Alfabetización Digital

OpenAIRE

Ramos, Martha; Rodrígez, Ana; Sánchez, Paz

2011-01-01

Inicio, POrtada, Introducción, Evaluación Diagnóstica y COntenido Tema 1¿Qué significala competencia de alfabetización digital en el uso de medios?, Tema 2 ¿Porque es relevante que adquiera la competencia de Alfabetización Digital en mi formación?, Tema 3 ¿Cómo aprender la competencia de Alfabetización Digital?, Tema 4 ¿Cóm aplico la competencia de Alfabetización Digital? Tema 5 ¿Cómo puede evaluar la competencia de alfabetización digital a través del empleo de un Wiki y blog educativos?...

Digital Living at Home

DEFF Research Database (Denmark)

Andersen, Pernille Viktoria Kathja; Christiansen, Ellen Tove

2013-01-01

of these user voices has directed us towards a ‘home-keeping’ design discourse, which opens new horizons for design of digital home control systems by allowing users to perform as self-determined controllers and groomers of their habitat. The paper concludes by outlining the implications of a ‘home......Does living with digital technology inevitably lead to digital living? Users talking about a digital home control system, they have had in their homes for eight years, indicate that there is more to living with digital technology than a functional-operational grip on regulation. Our analysis......-keeping’ design discourse....

Digital Disruption

DEFF Research Database (Denmark)

Rosenstand, Claus Andreas Foss

det digitale domæne ud over det niveau, der kendetegner den nuværende debat, så præsenteres der ny viden om digital disruption. Som noget nyt udlægges Clayton Christens teori om disruptiv innovation med et særligt fokus på små organisationers mulighed for eksponentiel vækst. Specielt udfoldes...... forholdet mellem disruption og den stadig accelererende digitale udvikling i konturerne til ny teoridannelse om digital disruption. Bogens undertitel ”faretruende og fascinerende forandringer” peger på, at der er behov for en nuanceret debat om digital disruption i modsætning til den tone, der er slået an i...... videre kalder et ”disruption-råd”. Faktisk er rådet skrevet ind i 2016 regeringsgrundlaget for VLK-regeringen. Disruption af organisationer er ikke et nyt fænomen; men hastigheden, hvormed det sker, er stadig accelererende. Årsagen er den globale mega-trend: Digitalisering. Og derfor er specielt digital...

The Digital Imperative

OpenAIRE

Veling, Louise; Murnane, Sinéad; Carcary, Marian; Zlydareva, Olga

2014-01-01

The pervasiveness of digital technologies and their potential for reshaping the industry landscape dictates that organizations operating today have little choice but to incorporate digital technologies into their business strategies. Failure to do so will impede the business’s viability, and may ultimately lead to business failure. However, for those organizations that successfully transition to digital business, unprecedented business opportunities exist for value creation and reali...

Alkylsilyl Peroxides as Alkylating Agents in the Copper-Catalyzed Selective Mono-N-Alkylation of Primary Amides and Arylamines.

Science.gov (United States)

Sakamoto, Ryu; Sakurai, Shunya; Maruoka, Keiji

2017-07-06

The copper-catalyzed selective mono-N-alkylation of primary amides or arylamines using alkylsilyl peroxides as alkylating agents is reported. The reaction proceeds under mild reaction conditions and exhibits a broad substrate scope with respect to the alkylsilyl peroxides, as well as to the primary amides and arylamines. Mechanistic studies suggest that the present reaction should proceed through a free-radical process that includes alkyl radicals generated from the alkylsilyl peroxides. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Hepatic steatosis progresses faster in HIV mono-infected than HIV/HCV co-infected patients and is associated with liver fibrosis.

Science.gov (United States)

Pembroke, Thomas; Deschenes, Marc; Lebouché, Bertrand; Benmassaoud, Amine; Sewitch, Maida; Ghali, Peter; Wong, Philip; Halme, Alex; Vuille-Lessard, Elise; Pexos, Costa; Klein, Marina B; Sebastiani, Giada

2017-10-01

Hepatic steatosis (HS) seems common in patients infected with human immunodeficiency virus (HIV). However, the relative effect of HIV, as well as hepatitis C virus (HCV) in those co-infected, and the influence of HS on liver fibrosis progression are unclear. The LIVEr disease in HIV (LIVEHIV) is a Canadian prospective cohort study using transient elastography and associated controlled attenuation parameter (CAP) to screen for HS and liver fibrosis, in unselected HIV-infected adults. HS progression was defined as development of any grade HS (CAP ⩾248dB/m), or transition to severe HS (CAP >292dB/m), for those with any grade HS at baseline. Fibrosis progression was defined as development of significant liver fibrosis (liver stiffness measurement [LSM] >7.1kPa), or transition to cirrhosis (LSM >12.5kPa) for those with significant liver fibrosis at baseline. Cox regression analysis was used to assess predictors of HS and fibrosis progression. A prospective cohort study was conducted, which included 726 HIV-infected patients (22.7% HCV co-infected). Prevalence of any grade HS did not differ between HIV mono-infected and HIV/HCV co-infected patients (36.1% vs. 38.6%, respectively). 313 patients were followed for a median of 15.4 (interquartile range 8.5-23.0) months. The rate of HS progression was 37.8 (95% confidence interval [CI] 29.2-49.0) and 21.9 (95% CI 15.6-30.7) per 100 person-years in HIV mono-infection and HIV/HCV co-infection, respectively. HCV co-infection was an independent negative predictor of HS progression (adjusted hazard ratio [aHR] 0.50, 95% CI 0.28-0.89). HS predicted liver fibrosis progression in HIV mono-infection (aHR 4.18, 95% CI 1.21-14.5), but not in HIV/HCV co-infection. HS progresses faster and is associated with liver fibrosis progression in HIV mono-infection but not in HIV/HCV co-infection. Lay summary: Fatty liver is the most frequent liver disease in Western countries. People living with HIV seem at high risk of fatty liver due to

Digital Immigrants and Digital Natives: Learning Business Informatics at Higher Educational Level

OpenAIRE

Suša, Dalia

2014-01-01

Background: The term digital natives refer to those born since the 1980s and have been growing up surrounded by technology. On the other hand, digital immigrants are born before 1980s and learned how to use technology later in life. Objectives: Goal of the paper is to explore attitudes of digital native students on the course of Business Informatics at higher educational institutions (HEIs), and to compare them with attitudes of digital immigrants. Methods/Approach: The survey was conducted i...

Digital Actuator Technology

Energy Technology Data Exchange (ETDEWEB)

Ken Thomas; Ted Quinn; Jerry Mauck; Richard Bockhorst

2014-09-01

There are significant developments underway in new types of actuators for power plant active components. Many of these make use of digital technology to provide a wide array of benefits in performance of the actuators and in reduced burden to maintain them. These new product offerings have gained considerable acceptance in use in process plants. In addition, they have been used in conventional power generation very successfully. This technology has been proven to deliver the benefits promised and substantiate the claims of improved performance. The nuclear industry has been reluctant to incorporate digital actuator technology into nuclear plant designs due to concerns due to a number of concerns. These could be summarized as cost, regulatory uncertainty, and a certain comfort factor with legacy analog technology. The replacement opportunity for these types of components represents a decision point for whether to invest in more modern technology that would provide superior operational and maintenance benefits. Yet, the application of digital technology has been problematic for the nuclear industry, due to qualification and regulatory issues. With some notable exceptions, the result has been a continuing reluctance to undertake the risks and uncertainties of implementing digital actuator technology when replacement opportunities present themselves. Rather, utilities would typically prefer to accept the performance limitations of the legacy analog actuator technologies to avoid impacts to project costs and schedules. The purpose of this report is to demonstrate that the benefits of digital actuator technology can be significant in terms of plant performance and that it is worthwhile to address the barriers currently holding back the widespread development and use of this technology. It addresses two important objectives in pursuit of the beneficial use of digital actuator technology for nuclear power plants: 1. To demonstrate the benefits of digital actuator

Metabolism of 14C-labelled urea in conventional, germ-free and mono-associated rats

International Nuclear Information System (INIS)

Juhr, N.C.; Franke, J.

1987-01-01

This report deals with the utilization of 14 C-labelled urea in conventional, defined associated and germ-free rats. With conventional animals 71.44% of the administered 14 C dose can be demonstrated in the exhaled air, 0.47% in organs and 27.35% in the urine. 1.04% were found in the intestinal and fecal contents. Animals mono-associated with Proteus mirabilis have nearly the same utilization rate (59.15, 0.34, 35.98, 2% resp.). In germ-free animals 1.21% of the activity appeared in the exhaled air and showed a small part of non-enzymatic hydrolysis of urea. The excretion of 97.70% in the urine shows, that urea is absorbed from the intestine in germ-free animals. (author)

Digital terrestrial broadcasting receiver in the U.K; Eikoku chijoha digital hoso jushinki

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

Digital terrestrial broadcasting is broadcasted in parallel with existing UHF analog broadcasting, whereas each of allocated channel frequencies can transmit five to six programs simultaneously. Each home can receive a number of programs with the existing antenna without a need of installing a new satellite antenna or cable. Among the countries of the world running forward to digitization of broadcasting all at once, the U.K. develops advancing movements and leads the world by starting the digital terrestrial broadcasting. In addition to the digitized broadcasting of conventional analog broadcasting programs, the `Ondigitals` (broadcasting operators) have started newly the pay broadcasting. Toshiba has been selected as one of the six developers and manufacturers of digital terrestrial broadcasting receivers, and has developed the digital terrestrial broadcasting receiver DTB2000. For the modulation system, the orthogonal frequency division multiplex (OFDM) was chosen as a system being strong against ghost and most suitable for digital terrestrial broadcasting. In addition, the receiver is equipped with software download function by using the broadcasting waves, and the common interface being the communication specification specified in the DVB (digital video broadcasting) to provide future function expandability. (translated by NEDO)

User Impact on Selection, Digitization, and the Development of Digital Special Collections

Science.gov (United States)

Mills, Alexandra

2015-01-01

Libraries and archives digitize their special collections in an effort to increase access to rare and unique items. To ensure that resulting digital collections meet user needs, institutions have made assessment, consultation, and user participation integral to digitization initiatives and the selection process. Institutions must also build…

Digital dannelse til gymnasieeleverne

DEFF Research Database (Denmark)

Kaarsted, Thomas; Holch Andersen, Knud

2012-01-01

Søsætningen af en ny tænketank skal udstikke nye digital retningslinjer for gymnasiekolerne. Baggrunden er en erkendelse af, at it-infrastruktur og digital teknologi ikke gør de alene.......Søsætningen af en ny tænketank skal udstikke nye digital retningslinjer for gymnasiekolerne. Baggrunden er en erkendelse af, at it-infrastruktur og digital teknologi ikke gør de alene....

Peperangan Generasi Digital Natives Melawan Digital Hoax Melalui Kompetisi Kreatif

Directory of Open Access Journals (Sweden)

Yanti Dwi Astuti

2017-12-01

threaten the unity and unity of the nation. Fenomena penyebaran hoax dan hate speech yang terjadi di dunia digital telah membawa kecemasan dan keprihatinan di dalam masyarakat. Banyak informasi hoax, hatespeech dan cyberbullying yang disebarkan oknum melalui Social Media dan Instant Messaging yang cenderung berbau SARA, provokatif dan bombastis. Ironisnya tidak sedikit pula masyarakat yang tanpa berpikir panjang langsung menshare informasi tersebut bahkan mereproduksi ulang informasi tanpa memikirkan dampak yang ditimbulkan setelahnya. Media digital saat ini didominasi oleh remaja yang lahir di zaman millennium yang merupakan “digital natives” yaitu generasi yang tidak dapat terpisahkan oleh dunia digital. Jika generasi ini tidak diberikan amunisi yang cukup untuk memerangi digital hoax, maka dikhawatirkan akan menimbulkan masalah dan bahaya laten. Menyikapi hal ini Prodi Ilkom UIN Sunan Kalijaga Yogyakarta melakukan kampanye anti-hoax dengan target pesertanya adalah mahasiswa yang merupakan remaja akhir dan dewasa awal yang dikemas melalui kegiatan ADUIN Fest 2017 “Nyepik Becik” (Pikirkan Apa yang Kamu Katakan” pada 17-18 Mei 2017. Metode pendekatannya dilakukan partisipatif dengan langsung mempraktekkannya melalui penciptaan karya-karya kreatif berupa Print-Ad, TVC dan film pendek oleh peserta yang dikompetisikan. Kemudian mengadakan creative seminar, pameran karya, Sharing Session dan Awarding Night. Harapannya anak-anak muda calon penerus bangsa ini menjadi cerdas, kritis dan mendapatkan pemahaman yang baik sehingga dapat memerangi digital hoax yang dapat mengancam persatuan dan kesatuan bangsa.

Digital radiography in NDT applications

International Nuclear Information System (INIS)

Deprins, E.

2004-01-01

A lot of film radiography could be replaced by today's technologies in the field of digital radiography. Only few of these applications have indeed replaced film. The choice to go digital depends on cost, quality requirement, workflow and throughput. Digital images offer a lot of advantages in terms of image manipulation and workflow. But despite the many advantages, a lot of considerations are needed before someone can decide to convert his organization from conventional to digital radiography. This paper gives an overview of all different modalities that can be used in digital radiography with today's technologies, together with the experiences of the pioneers of digital radiography. Film Scanning, Computed Radiography and Digital Radiography by using of different kinds of flat panel detectors all have their specific application fields and customers. What is the status of the technology today, which advantages brings digital radiography, and which are the limitations radiographers have to consider when replacing film by digital systems. (author)

Laboratory Directed Research and Development (LDRD) on Mono-uranium Nitride Fuel Development for SSTAR and Space Applications

International Nuclear Information System (INIS)

Choi, J; Ebbinghaus, B; Meiers, T; Ahn, J

2006-01-01

The US National Energy Policy of 2001 advocated the development of advanced fuel and fuel cycle technologies that are cleaner, more efficient, less waste-intensive, and more proliferation resistant. The need for advanced fuel development is emphasized in on-going DOE-supported programs, e.g., Global Nuclear Energy Initiative (GNEI), Advanced Fuel Cycle Initiative (AFCI), and GEN-IV Technology Development. The Directorates of Energy and Environment (E and E) and Chemistry and Material Sciences (C and MS) at Lawrence Livermore National Laboratory (LLNL) are interested in advanced fuel research and manufacturing using its multi-disciplinary capability and facilities to support a design concept of a small, secure, transportable, and autonomous reactor (SSTAR). The E and E and C and MS Directorates co-sponsored this Laboratory Directed Research and Development (LDRD) Project on Mono-Uranium Nitride Fuel Development for SSTAR and Space Applications. In fact, three out of the six GEN-IV reactor concepts consider using the nitride-based fuel, as shown in Table 1. SSTAR is a liquid-metal cooled, fast reactor. It uses nitride fuel in a sealed reactor vessel that could be shipped to the user and returned to the supplier having never been opened in its long operating lifetime. This sealed reactor concept envisions no fuel refueling nor on-site storage of spent fuel, and as a result, can greatly enhance proliferation resistance. However, the requirement for a sealed, long-life core imposes great challenges to research and development of the nitride fuel and its cladding. Cladding is an important interface between the fuel and coolant and a barrier to prevent fission gas release during normal and accidental conditions. In fabricating the nitride fuel rods and assemblies, the cladding material should be selected based on its the coolant-side corrosion properties, the chemical/physical interaction with the nitride fuel, as well as their thermal and neutronic properties. The US

The digital spine

DEFF Research Database (Denmark)

Ebbesen, Toke Riis

2019-01-01

In the words of the Oxford English Dictionary, a book is 'a portable volume consisting of a series of written, printed, or illustrated pages bound together for ease of reading' (‘book, n.’nd). Yet, the world of books isn’t what it used to be. If differences between media are material differences...... analyze books as digital or even 'post-digital' artifacts (Cramer 2014), while preserving the material dimension of the book artifact. In other words: is there is such a thing as a (post-)digital spine, and how can it be described? This article outlines an answer to this question within an inferential...... (Seiter 2015), and books are produced, distributed and read on various digital media and devices, it is no longer possible to understand digital books on the basis of the material and syntactical features of the codex artifact. It then becomes important to discuss how to conceptualize and subsequently...

Reduction of digital errors of digital charge division type position-sensitive detectors

International Nuclear Information System (INIS)

Uritani, A.; Yoshimura, K.; Takenaka, Y.; Mori, C.

1994-01-01

It is well known that ''digital errors'', i.e. differential non-linearity, appear in a position profile of radiation interactions when the profile is obtained with a digital charge-division-type position-sensitive detector. Two methods are presented to reduce the digital errors. They are the methods using logarithmic amplifiers and a weighting function. The validities of these two methods have been evaluated mainly by computer simulation. These methods can considerably reduce the digital errors. The best results are obtained when both methods are applied. ((orig.))

Synthesis, chemical and biological properties of the new mono- and bis-derivatives of imidazoles

Directory of Open Access Journals (Sweden)

E. V. Welchinska

2014-12-01

Institute of Pharmacology and Toxicology of National Academy of Medical Sciences of Ukraine. The lectin’s preparations were obtained by treatment of culture Liquid of saprophytic strain Bacillus from Ukrainian Collection of Microorganisms of Institute of Microbiology and Virology (IMV: B. polymyxa 102 KGU; in future: lectine 102 was clarified by treatment with ammonium sulfate (70% concentration of a saturated solution. Results. For the first time the interaction of a series of imidazole substituted with halothane compounds have been investigated, the conditions of the reaction have been defined, the methods have been developed and the composition of the reaction products has been studied. The studies revealed that the initial heterocycle, namely imidazole reacts with the intermediate product of halothane conversion in an alkaline medium, under conditions of phase transfer catalysis DB-18-crown-6 in a solvent system (dimethyl formamide - benzene - diethyl ether or in another variant: in DMSO with the presence of anhydrous potassium carbonate with the formation of mono-and bis-derivatives of imidazole. This reaction made possible a new strategy of synthesis of selectively poly-functionalized molecules, the chemical structure of which is available for incorporation of new pharmacophore fragments into molecule. It has been discovered that mono-, bis-derivatives of imidazole, molecular complex of bis-derivative of imidazole and antitumour bacterial lectin are low toxic preparations (LD50: from 278 mg/kg to 102 mg/kg. Conclusion. New mono- and bis-adducts of imidazole, molecular complex of Bacillus polymyxa 102 KGU and imidazole bis-derivative have been prepared and its toxicity has been tested. New convenient methods for the preparation of heterocyclic mono- and bis-adducts of imidazole with 1,1,1-trifluoro-2-bromo-2-chloroethane (halothane have been described. The reactions were catalyzed by DB-18-crown-6-complex (at the alkali medium. Investigation of the critical toxicity

Preserving Digital Materials

CERN Document Server

Harvey, Ross

2011-01-01

This book provides a single-volume introduction to the principles, strategies and practices currently applied by librarians and recordkeeping professionals to the critical issue of preservation of digital information. It incorporates practice from both the recordkeeping and the library communities, taking stock of current knowledge about digital preservation and describing recent and current research, to provide a framework for reflecting on the issues that digital preservation raises in professional practice.

DSA in digital replantations

International Nuclear Information System (INIS)

Wang Liuhong; Chao Ming; Jiang Dingyao; Zhang Guangqiang; Wu Jianjun; Chen Xianyi; Li Bin; Sun Jihong

2008-01-01

Objective: To assess revascularization and vessel anastomosis in digital replantations with DSA. Methods: Twelve cases of digital replantations underwent digital subtract angiography during 2 to 4 days after fingers reattachment. The vessel anastomosis, hemodynamics, stenosis and discontinuation were investigated. The unobstructed and smooth anastomosis was suggested as early stage survival of the reattached fingers, the spasm and stenosis of the reattached vessels were considered as mild vascular crisis, and the discontinuation of hemodynamics were indicated as severe vascular crisis. Results: The total 27 vessels were clearly displayed on DSA. Of these vessels, 23 vessels were unobstructed and smooth, all digits were survived. Diagnosis coincidence of early stage survival was 100% (23/23). Two vessels were obstructed, which were testified having thrombus by operation research. The other 2 vessels were spasm, the digits were also survived ultimately by expectant treatment. All 4 abnormal vessel anatomosis were found by DSA. Conclusion: DSA is important modality in assessing revascularization and blood circulation for digital replantations, guiding in dealing with the vascular crisis, and in predicting early stage survival of the reattached digits. (authors)

Digital radiology and ultrasound

International Nuclear Information System (INIS)

Todd-Pokropek, A.

1991-01-01

With the access to digital methods for handling and processing images in general, many medical imaging methods are becoming more effectively handled digitally. This applies in particular to basically digital techniques such as CT and MR but also now includes Nuclear Medicine (NM), Ultrasound (US) and a variety of radiological procedures such as Digital Subtraction Angiography (DSA) and Fluoroscopy (DF). The access to conventional projection images by stimulatable plates (CR) or by digitization of film makes all of radiology potentially accessible, and the management of such images by a network is the basic aim of Picture Archiving and Communication Systems (PACS). However, it is suggested that in order for such systems to be of greater value, that way in which such images are treated needs to change, that is, digital images can be used to derive additional clinical value by appropriate processing

The digital Emily project: achieving a photorealistic digital actor.

Science.gov (United States)

Alexander, Oleg; Rogers, Mike; Lambeth, William; Chiang, Jen-Yuan; Ma, Wan-Chun; Wang, Chuan-Chang; Debevec, Paul

2010-01-01

The Digital Emily Project uses advanced face scanning, character rigging, performance capture, and compositing to achieve one of the world's first photorealistic digital facial performances. The project scanned the geometry and reflectance of actress Emily O'Brien's face in 33 poses, showing different emotions, gaze directions, and lip formations in a light stage. These high-resolution scans-accurate to skin pores and fine wrinkles-became the basis for building a blendshape-based facial-animation rig whose expressions closely matched the scans. The blendshape rig drove displacement maps to add dynamic surface detail. A video-based facial animation system animated the face according to the performance in a reference video, and the digital face was tracked onto the video's motion and rendered under the same illumination. The result was a realistic 3D digital facial performance credited as one of the first to cross the "uncanny valley" between animated and fully human performances.

Ageing and digital games

DEFF Research Database (Denmark)

Iversen, Sara Mosberg

Digital games are still to a great degree considered a medium mainly for young boys. However, available statistics on Western media use show that this is far from the case. Increasingly, people of all ages and genders play digital games, also older adults in their early 60s and beyond. The aim...... of the book is to examine, analyse and discuss: 1) What older adults do with digital games and what meanings the use of digital games take on in the everyday life of older adults; 2) How older adults are perceived by society in relation to digital games; 3) How play and games can be used both...

The Digital Outcasts - Advanced Margins in Digital Societies

DEFF Research Database (Denmark)

Hjelholt, Morten

2015-01-01

This work-in-progress paper reports on preliminary findings from 15 interviews with so called “non-digital” Danish citizens to address and problematize this classification as a social category. In linking classification theory (the categories used in the digital post system) to a notion of advanced...... further work will use the concept of advanced digital marginalization, to elaborate on these findings....

Digital Inkjet Textile Printing

OpenAIRE

Wang, Meichun

2017-01-01

Digital inkjet textile printing is an emerging technology developed with the rise of the digital world. It offers a possibility to print high-resolution images with unlimited color selection on fabrics. Digital inkjet printing brings a revolutionary chance for the textile printing industry. The history of textile printing shows the law how new technology replaces the traditional way of printing. This indicates the future of digital inkjet textile printing is relatively positive. Differen...

Performing Digital Literature

Directory of Open Access Journals (Sweden)

Jerome Fletcher

2015-11-01

Full Text Available Digital literature is a complex assemblage of related elements –material, spatial, linguistic, performative, textual, cultural, social– each of which is at one time interdependent and detached. This article discusses the literary creation within the cyberculture from the performativity point of view in relation to the textual apparatus. This is done through the analysis of a selection of performances where physical corporeality has a collaborative function with the body to a greater or lesser degree. Therefore, this physical feature can not only change, but stand at three possible and hybridizable axes: 1 the digital text as protagonist, 2 the digital text as counterpart, and 3 the digital text as site.

Crystalline mono- and multilayer self-assemblies of oligothiophenes at the air-water interface

DEFF Research Database (Denmark)

Isz, S.; Weissbuch, I.; Kjær, K.

1997-01-01

The formation of Langmuir monolayers at the air-water interface has long been believed to be limited to amphiphilic molecules containing a hydrophobic chain and a hydrophilic headgroup. Here we report the formation of crystalline mono- and multilayer self-assemblies of oligothiophenes, a class...... of aromatic nonamphiphilic molecules, self-aggregated at the air-water interface. As model systems we have examined the deposition of quaterthiophene (S-4), quinquethiophene (S-5). and sexithiophene (S-6) from chloroform solutions on the water surface. The structures of the films were determined by surface...... surface. S-5 self-ageregates at the water surface to form mixtures of monolayers and bilayers of the beta polymorph; S-6 forms primarily crystalline monolayers of both alpha and beta forms. The crystalline assemblies preserve their integrity during transfer from the water surface onto solid supports...

Teaching digital pathology: The international school of digital pathology and proposed syllabus

Directory of Open Access Journals (Sweden)

Vincenzo Della Mea

2017-01-01

Full Text Available Digital pathology is an interdisciplinary field where competency in pathology, laboratory techniques, informatics, computer science, information systems, engineering, and even biology converge. This implies that teaching students about digital pathology requires coverage, expertise, and hands-on experience in all these disciplines. With this in mind, a syllabus was developed for a digital pathology summer school aimed at professionals in the aforementioned fields, as well as trainees and doctoral students. The aim of this communication is to share the context, rationale, and syllabus for this school of digital pathology.

Irradiation of micro-organisms with mono-energetic X-rays; biological consequences of the Auger effect

Energy Technology Data Exchange (ETDEWEB)

Halpern, A; Muetze, B [Kernforschungsanlage Juelich G.m.b.H. (Germany, F.R.)

1978-07-01

The radiation resonance effect reported previously for isolated biomolecules has now for the first time been observed in a cellular system. Dried bacteria, Micrococcus denitrificans, in which TdR in DNA was partially substituted by BUdR, were subjected to mono-energetic X-rays of energies below or above the K-edge for Br. Subsequently, the colony-forming ability was assayed. For photon energy slightly above the K-edge, the lethality/rad was greater than that below the K-edge. This is interpreted in terms of the Auger effect initiated selectively by photo-absorption in constituent Br atoms. The differential absorption of low-energy photons in constituent atoms of DNA is also discussed.