Frank-ter Haar syndrome--additional findings?

Science.gov (United States)

Köse, Taha Emre; İşler, Cemil; Şenel, Ş Neslihan; Şitilci, Tolga; Özcan, İlknur; Aksakallı, Nihan

2016-01-01

Frank-ter Haar syndrome is a genetic disease that is transmitted by autosomal recessive pattern with characteristic features such as megalocornea or glaucoma, a prominent coccyx, heart defects, developmental delays, brachycephaly, a wide anterior fontanel, finger flexion deformities, full cheeks and micrognathia. Dentomaxillofacial features of this syndrome are not well documented in the literature. We present of a 21-year-old male with Frank-ter Haar syndrome and some features that may be linked with this syndrome not reported before in the literature.

Frank Krienen (1917-2008)

CERN Multimedia

2008-01-01

Amsterdam, summer 1952: it was here that the first recruits for CERN ‘s 600 MeV Synchrocyclotron project met Frank Krienen for the first time. A young assistant to Prof. C.J. Bakker at the Physics Institute, he soon became the mastermind behind the most daring aspects of the project: the frequency modulating circuit, based on a vibrating tuning fork, was his creation. He was a respected and inspiring leader throughout the construction period of the accelerator and, at the same time, an older brother and an exacting mentor. Frank later devoted himself to developing particle detectors, in particular spark wire chambers using different types of readout. His next major involvement at CERN was his contribution to the glorious g-2 saga. Frank’s contributions to the last experiment of the anomalous magnetic moment of the muon (g-2) done at CERN (1969-1977) were very important in many aspects. The last (g-2) experiment was based on many...

Frank Blythe (1924-2010)

CERN Multimedia

2010-01-01

Frank Blythe, one of the very first engineers engaged in the CERN adventure, passed away on October 22. Born and educated in Salford (England), after a time spent at Metropolitan-Vickers in Manchester, in January 1954 he joined the group at the Nuclear Physics Research Laboratory in Liverpool that was working on the first CERN accelerator, the Synchrocyclotron (SC). At that time CERN had not yet officially been constituted, yet had a well defined work programme, the design and construction work being carried out in various European laboratories. In Liverpool the work included the SC vacuum and cooling system, radiation shielding, experimental areas and beams. By the end of 1954, Frank reached the CERN premises in Geneva, and contributed significantly to the successful construction work of the Synchrocyclotron. He later became responsible for the drawing office and the mechanical workshop (Engineering Group) attached to the MSC Division, and also serving the NP/EP Division. He kept this position until ...

Cotton, Prof. Frank Albert

Indian Academy of Sciences (India)

... Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Fellowship. Fellow Profile. Elected: 1985 Honorary. Cotton, Prof. Frank Albert. Date of birth: 9 April 1930. Date of death: 20 February 2007. Last known address: Department of Chemistry, Texas A & M University, College Station, TX 77843, U.S.A..

Frank-ter Haar syndrome associated with sagittal craniosynostosis and raised intracranial pressure.

Science.gov (United States)

Bendon, Charlotte L; Fenwick, Aimée L; Hurst, Jane A; Nürnberg, Gudrun; Nürnberg, Peter; Wall, Steven A; Wilkie, Andrew O M; Johnson, David

2012-11-09

Frank-ter Haar syndrome is a rare disorder associated with skeletal, cardiac, ocular and craniofacial features including hypertelorism and brachycephaly. The most common underlying genetic defect in Frank-ter Haar syndrome appears to be a mutation in the SH3PXD2B gene on chromosome 5q35.1. Craniosynostosis, or premature fusion of the calvarial sutures, has not previously been described in Frank-ter Haar syndrome. We present a family of three affected siblings born to consanguineous parents with clinical features in keeping with a diagnosis of Frank-ter Haar syndrome. All three siblings have a novel mutation caused by the deletion of exon 13 of the SH3PXD2B gene. Two of the three siblings also have non-scaphocephalic sagittal synostosis associated with raised intracranial pressure. The clinical features of craniosynostosis and raised intracranial pressure in this family with a confirmed diagnosis of Frank-ter Haar syndrome expand the clinical spectrum of the disease. The abnormal cranial proportions in a mouse model of the disease suggests that the association is not coincidental. The possibility of craniosynostosis should be considered in individuals with a suspected diagnosis of Frank-ter Haar syndrome.

Frank Capra and Elia Kazan, American outsiders

Directory of Open Access Journals (Sweden)

Yves Carlet

2010-11-01

Full Text Available Frank Capra and Elia Kazan both came to the United States as children. From immigrant stock, each experienced the effects of being looked down upon as outsiders to Anglo culture. Based on the two men’s autobiographical accounts, together with their films and biographical writings about them, this article examines the routes by which they sought entry into the dominant culture. This process would require the rejection, in each case, of part of his family heritage. It would lead to very different attitudes to ethnicity in their films: Kazan demonstrated interest in the subject, whereas Capra largely suppressed it. The article underlines other “covert dialogues” in the films directed by the two men. It shows that they most diverged over issues of sexuality and the later rediscovery of their ethnic roots.

Anne Frank relaunched in the world of comics and graphic novels

NARCIS (Netherlands)

Ribbens, Kees

2017-01-01

Recently the Basel-based Anne Frank Fonds proudly presented the Graphic Diary of Anne Frank. The impression is created as if this is the first ever comic book version of Anne Frank’s narrative. This article shows that there were various predecessors.

Mortimer Frank, Johann Ludwig Choulant, and the history of anatomical illustration.

Science.gov (United States)

Feibel, Robert M

2018-01-01

Mortimer Frank (1874-1919) was an ophthalmologist in Chicago, Illinois. He published a number of papers on the history of medicine, and was secretary of the Chicago Society of the History of Medicine and editor of their Bulletin. His major contribution to the history of medicine relates to the history of anatomical illustration. The classic book on that subject had been published in 1852 in German by the physician and historian, Johann Ludwig Choulant (1791-1861). However, by Frank's time this text was both out dated and out of print. Frank took on the tremendous project of translating Choulant's German text into English as History and Bibliography of Anatomic Illustration in Its Relation to Anatomic Science and The Graphic Arts. He improved Choulant's text with the results of his and other scholars' research, greatly enlarging the text. Frank supplemented the original book with a biography of Choulant, essays on anatomists not considered in the original text, and an essay on the history of anatomical illustration prior to those authors discussed by Choulant. This book, now referred to as Choulant/Frank, has been reprinted several times, and is still useful as a reference in this field, though some of its research is now dated.

Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia

Directory of Open Access Journals (Sweden)

Naida L. Graham

2016-09-01

Full Text Available Background/Aims: Frank agrammatism, defined as the omission and/or substitution of grammatical morphemes with associated grammatical errors, is variably reported in patients with nonfluent variant primary progressive aphasia (nfPPA. This study addressed whether frank agrammatism is typical in agrammatic nfPPA patients when this feature is not required for diagnosis. Method: We assessed grammatical production in 9 patients who satisfied current diagnostic criteria. Although the focus was agrammatism, motor speech skills were also evaluated to determine whether dysfluency arose primarily from apraxia of speech (AOS, instead of, or in addition to, agrammatism. Volumetric MRI analyses provided impartial imaging-supported diagnosis. Results: The majority of cases exhibited neither frank agrammatism nor AOS. Conclusion: There are nfPPA patients with imaging-supported diagnosis and preserved motor speech skills who do not exhibit frank agrammatism, and this may persist beyond the earliest stages of the illness. Because absence of frank agrammatism is a subsidiary diagnostic feature in the logopenic variant of PPA, this result has implications for differentiation of the nonfluent and logopenic variants, and indicates that PPA patients with nonfluent speech in the absence of frank agrammatism or AOS do not necessarily have the logopenic variant.

Frank C. Laubach, Literacy Pioneer.

Science.gov (United States)

Kearney, Linda

A fervent idealist whose dream was to eliminate illiteracy throughout the world, Frank C. Laubach sought to bring Christianity to the masses by giving them the ability to read and spread the teachings of the Bible. In working with people in the nonindustrialized nations, Laubach also saw the need for economic and political self-sufficiency. He…

The regenerative medicine coalition. Interview with Frank-Roman Lauter.

Science.gov (United States)

Lauter, Frank-Roman

2012-11-01

Frank-Roman Lauter, Secretary General of the recently launched Regenerative Medicine Coalition, explains how the coalition was formed and what they hope to achieve. Frank-Roman Lauter has served as Secretary General of the Regenerative Medicine Coalition since 2012, and as Head of Business Development at Berlin-Brandenburg Center for Regenerative Therapies since 2007. Frank-Roman Lauter's interest is the organization of academic infrastructures to promote efficient translation of research findings into new therapies. He co-organizes joined strategy development for regenerative medicine clusters from seven European countries (FP7-EU Project) and has initiated cooperation between the California Institute for Regenerative Medicine and the German Federal Ministry for Education & Research, resulting in a joined funding program. Recently, he cofounded the international consortium of Regenerative Medicine translational centers (RMC; www.the-rmc.org ). Trained as a molecular biologist at the Max-Planck Institute in Berlin-Dahlem and at Stanford, he has 16 years of experience as an entrepreneur and life science manager in Germany and the USA.

Use of the Frank sequence in pulsed EPR

DEFF Research Database (Denmark)

Tseitlin, Mark; Quine, Richard W.; Eaton, Sandra S.

2011-01-01

The Frank polyphase sequence has been applied to pulsed EPR of triarylmethyl radicals at 256MHz (9.1mT magnetic field), using 256 phase pulses. In EPR, as in NMR, use of a Frank sequence of phase steps permits pulsed FID signal acquisition with very low power microwave/RF pulses (ca. 1.5m......W in the application reported here) relative to standard pulsed EPR. A 0.2mM aqueous solution of a triarylmethyl radical was studied using a 16mm diameter cross-loop resonator to isolate the EPR signal detection system from the incident pulses. Keyword: Correlation spectroscopy,Multi-pulse EPR,Low power pulses,NMR,EPR...

75 FR 51429 - Definitions Contained in Title VII of Dodd-Frank Wall Street Reform and Consumer Protection Act

Science.gov (United States)

2010-08-20

... VII of Dodd-Frank Wall Street Reform and Consumer Protection Act AGENCY: Securities and Exchange... comments. SUMMARY: The Dodd-Frank Wall Street Reform and Consumer Protection Act (the ``Dodd-Frank Act... requirements. \\1\\ Dodd-Frank Wall Street Reform and Consumer Protection Act, Public Law No. 111-203, 124 Stat...

Numerical analysis of stress effects on Frank loop evolution during irradiation in austenitic Fe-Cr-Ni alloy

International Nuclear Information System (INIS)

Tanigawa, H.; Katoh, Y.; Kohyama, A.

1995-01-01

Effects of applied stress on early stages of interstitial type Frank loop evolution were investigated by both numerical calculation and irradiation experiments. The final objective of this research is to propose a comprehensive model of complex stress effects on microstructural evolution under various conditions. In the experimental part of this work, the microstructural analysis revealed that the differences in resolved normal stress caused those in the nucleation rates of Frank loops on {111} crystallographic family planes, and that with increasing external applied stress the total nucleation rate of Frank loops was increased. A numerical calculation was carried out primarily to evaluate the validity of models of stress effects on nucleation processes of Frank loop evolution. The calculation stands on rate equations which describe evolution of point defects, small points defect clusters and Frank loops. The rate equations of Frank loop evolution were formulated for {111} planes, considering effects of resolved normal stress to clustering processes of small point defects and growth processes of Frank loops, separately. The experimental results and the predictions from the numerical calculation qualitatively coincided well with each other. (orig.)

For an aesthetics of communication: Interview with Frank Hartmann Por uma estética da comunicação: entrevista com Frank Hartmann

Directory of Open Access Journals (Sweden)

Lucia Leao

2011-07-01

Full Text Available In August 18, 2010, Frank Hartmann was present at the Post Graduate Program in Communication and Semiotics of PUC-SP, where he lectured on the following theme: “Towards an aesthetics of communication”. Frank Hartmann is full professor at the Bauhaus University, Weimar in Germany and external faculty member at the Dept. of Communication, University of Vienna, Austria. He is the author, among others, of: Medien und Kommunikation (2008; Mediologie - Ansatz einer der Medientheorie Kulturwissenschaften (2003, and Medienphilosophie (2000. More information on his website: http://www.medienphilosophie.net/f_hartmann.htmlFrank Hartmann esteve no dia 18 de agosto de 2010 no Programa de Pós-Graduação em Comunicação e Semiótica da PUC-SP, onde proferiu a palestra “Towards an aesthetics of communication”. Hartmann é professor titular da Universidade Bauhaus, em Weimar, na Alemanha e professor convidado do Departamento de Comunicação da Universidade de Viena, na Áustria. É autor, entre outros, de: Medien und Kommunikation (2008; Mediologie – Ansätze einer Medientheorie der Kulturwissenschaften (2003; e Medienphilosophie (2000. Mais informações em seu site: http://www.medienphilosophie.net/f_hartmann.html

A Frank mixture copula family for modeling higher-order correlations of neural spike counts

International Nuclear Information System (INIS)

Onken, Arno; Obermayer, Klaus

2009-01-01

In order to evaluate the importance of higher-order correlations in neural spike count codes, flexible statistical models of dependent multivariate spike counts are required. Copula families, parametric multivariate distributions that represent dependencies, can be applied to construct such models. We introduce the Frank mixture family as a new copula family that has separate parameters for all pairwise and higher-order correlations. In contrast to the Farlie-Gumbel-Morgenstern copula family that shares this property, the Frank mixture copula can model strong correlations. We apply spike count models based on the Frank mixture copula to data generated by a network of leaky integrate-and-fire neurons and compare the goodness of fit to distributions based on the Farlie-Gumbel-Morgenstern family. Finally, we evaluate the importance of using proper single neuron spike count distributions on the Shannon information. We find notable deviations in the entropy that increase with decreasing firing rates. Moreover, we find that the Frank mixture family increases the log likelihood of the fit significantly compared to the Farlie-Gumbel-Morgenstern family. This shows that the Frank mixture copula is a useful tool to assess the importance of higher-order correlations in spike count codes.

Congenital glaucoma as an ophthalmic manifestation of Frank-Ter Haar syndrome.

Science.gov (United States)

Aktas, Zeynep; Karaca, Emine Esra; Dogan, Nurcan; Çakmak, Tugba; Unlu, Metin; Tok, Levent; Hasanreisoglu, Murat

2014-04-01

We report on a patient with Frank-Ter Haar syndrome that is associated with high intraocular pressures. A 21-day-old male patient was referred to our clinic for surgical treatment of congenital glaucoma. On ophthalmic examination, he had buphthalmos, mild corneal edema and high IOP readings in both eyes. The patient underwent uneventful trabeculotomy surgery, bilaterally. Marked bilateral anterior iris insertion was noted during the surgery. Childhood glaucoma may be associated with Frank-Ter Haar syndrome.

Frank-Ter Haar syndrome in a newborn.

Science.gov (United States)

Femitha, P; Joy, Rojo; Gane, Bahubali D; Adhisivam, B; Bhat, B Vishnu

2012-08-01

Frank-Ter Haar syndrome is an unusual type of skeletal dysplasia with megalocornea and developmental delay. It is usually transmitted as autosomal recessive disorder. Only a few cases have been reported in the literature and none from India. The authors report a case with other unusual features and a short review of the condition.

Isocyanate leading to Guanidines/Urea derivatives formation

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences; Volume 128; Issue 6. Zinc catalyzed Guanylation reaction of Amines with Carbodiimides/ Isocyanate leading to Guanidines/Urea derivatives formation. JAYEETA BHATTACHARJEE MITALI SACHDEVA INDRANI BANERJEE TARUN K PANDA. Regular Article Volume 128 ...

Personal Identification Based on Vectorcardiogram Derived from Limb Leads Electrocardiogram

Directory of Open Access Journals (Sweden)

Jongshill Lee

2012-01-01

Full Text Available We propose a new method for personal identification using the derived vectorcardiogram (dVCG, which is derived from the limb leads electrocardiogram (ECG. The dVCG was calculated from the standard limb leads ECG using the precalculated inverse transform matrix. Twenty-one features were extracted from the dVCG, and some or all of these 21 features were used in support vector machine (SVM learning and in tests. The classification accuracy was 99.53%, which is similar to the previous dVCG analysis using the standard 12-lead ECG. Our experimental results show that it is possible to identify a person by features extracted from a dVCG derived from limb leads only. Hence, only three electrodes have to be attached to the person to be identified, which can reduce the effort required to connect electrodes and calculate the dVCG.

"Frank" presentations as a novel research construct and element of diagnostic decision-making in autism spectrum disorder.

Science.gov (United States)

de Marchena, Ashley; Miller, Judith

2017-04-01

Many individuals with ASD have a distinctive behavioral presentation that is recognizable within moments, a phenomenon we call "frank" ASD. This phenomenon has been discussed informally for decades, perhaps as "classic" ASD; however, there is no unitary "classic" presentation, and classic autism does not seem to correspond to level of functioning. Thus, neither "frank" nor "classic" autism has been delineated or studied as a research construct. To initiate the empirical study of frank ASD, we surveyed 151 clinicians, from a range of disciplines that diagnose ASD, about this phenomenon. Respondents completed a 13-item questionnaire about frank ASD, which was analyzed using a mixed-methods approach. Ninety-seven percentage of respondents were familiar with the phenomenon. Respondents estimated that 40% of the ASD population has a frank presentation. Respondents reported the most highly specific behaviors associated with frank presentations were a general sense of impaired reciprocity, quality of eye contact, atypical vocal prosody, presence of motor mannerisms, and atypical gait or posture. In general, respondents reported detecting frank features rapidly, with the majority forming their impressions within the first ten minutes of interaction or observation. Although unstudied empirically, "frank" presentations of ASD are familiar to diagnosing clinicians, and appear to be based on behaviors both central to ASD diagnostic criteria (e.g., impaired reciprocity), and absent from diagnostic criteria (e.g., atypical gait or posture). We discuss these findings within the context of diagnostic decision-making and behavioral phenotyping of ASD. Autism Res 2016,. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. Autism Res 2017, 10: 653-662. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

Derivation of orthogonal leads from the 12-lead electrocardiogram. Performance of an atrial-based transform for the derivation of P loops.

Science.gov (United States)

Guillem, M Salud; Sahakian, Alan V; Swiryn, Steven

2008-01-01

The objective of this study was the evaluation of the accuracy of Dower inverse transform for the derivation of the P wave in orthogonal leads. We tested the accuracy of Dower transform on the P wave and compared it with a P-wave-optimized transform in a database of 123 simultaneous recordings of electrocardiograms and vectorcardiograms. This new transform achieved a lower error when we compared derived vs true measured P waves (mean +/- SD, 12.2 +/- 8.0 VRMS) than Dower transform (14.4 +/- 9.5 Root mean squared voltage) and higher correlation values (Rx, 0.93 +/- 0.12; Ry, 0.90 +/- 0.27; Rz, 0.91 +/- 0.18; vs Dower: Rx, 0.88 +/- 0.15; Ry, 0.91 +/- 0.26; Rz, 0.85 +/- 0.23). We conclude that derivation of orthogonal leads for the P wave can be improved by using an atrial-based transform matrix.

9 CFR 319.180 - Frankfurter, frank, furter, hotdog, weiner, vienna, bologna, garlic bologna, knockwurst, and...

Science.gov (United States)

2010-01-01

...) Frankfurter, frank, furter, hot-dog, wiener, vienna, bologna, garlic bologna, knockwurst and similar cooked... accordance with the provisions of § 381.118 of this chapter. (b) Frankfurter, frank, furter, hot-dog, wiener..., lips, weasands, and spleens; and partially defatted pork fatty tissue, or partially defatted beef fatty...

78 FR 1306 - Transition Period Under Section 716 of the Dodd-Frank Wall Street Reform and Consumer Protection Act

Science.gov (United States)

2013-01-08

... DEPARTMENT OF THE TREASURY Office of the Comptroller of the Currency [Docket ID OCC-2013-0001] Transition Period Under Section 716 of the Dodd-Frank Wall Street Reform and Consumer Protection Act AGENCY... Dodd-Frank Wall Street Reform and Consumer Protection Act (Dodd-Frank Act) prohibits providing Federal...

78 FR 68887 - Dodd-Frank Investor Advisory Committee; Meeting

Science.gov (United States)

2013-11-15

... Investor Advisory Committee; Meeting AGENCY: Securities and Exchange Commission. ACTION: Notice of Meeting of Securities and Exchange Commission Dodd- Frank Investor Advisory Committee. SUMMARY: The Securities and Exchange Commission Investor Advisory Committee, established pursuant to Section 911 of the...

Limitations of Dower's inverse transform for the study of atrial loops during atrial fibrillation.

Science.gov (United States)

Guillem, María S; Climent, Andreu M; Bollmann, Andreas; Husser, Daniela; Millet, José; Castells, Francisco

2009-08-01

Spatial characteristics of atrial fibrillatory waves have been extracted by using a vectorcardiogram (VCG) during atrial fibrillation (AF). However, the VCG is usually not recorded in clinical practice and atrial loops are derived from the 12-lead electrocardiogram (ECG). We evaluated the suitability of the reconstruction of orthogonal leads from the 12-lead ECG for fibrillatory waves in AF. We used the Physikalisch-Technische Bundesanstalt diagnostic ECG database, which contains 15 simultaneously recorded signals (12-lead ECG and three Frank orthogonal leads) of 13 patients during AF. Frank leads were derived from the 12-lead ECG by using Dower's inverse transform. Derived leads were then compared to true Frank leads in terms of the relative error achieved. We calculated the orientation of AF loops of both recorded orthogonal leads and derived leads and measured the difference in estimated orientation. Also, we investigated the relationship of errors in derivation with fibrillatory wave amplitude, frequency, wave residuum, and fit to a plane of the AF loops. Errors in derivation of AF loops were 68 +/- 31% and errors in the estimation of orientation were 35.85 +/- 20.43 degrees . We did not find any correlation among these errors and amplitude, frequency, or other parameters. In conclusion, Dower's inverse transform should not be used for the derivation of orthogonal leads from the 12-lead ECG for the analysis of fibrillatory wave loops in AF. Spatial parameters obtained after this derivation may differ from those obtained from recorded orthogonal leads.

Random walks, Brownian motion, and interacting particle systems: a festschrift in honor of Frank Spitzer

National Research Council Canada - National Science Library

Durrett, Richard; Kesten, Harry; Spitzer, Frank

1991-01-01

..., made the transparency used in the printing process. STUDENTS OF FRANK SPITZERSTUDENTS OF FRANK SPITZER 1957 J. W. Lamperti, On the asymptotic behavior of recurrent and almostrecurrent events. 1964 W. W. Whitman, Some strong laws for random walks and Brownian motion. 1965 J. C. Mineka, The existence and uniqueness of positive solutions to the Wien...

Numerical analysis of stress effects on Frank loop evolution during irradiation in austenitic Fe&z.sbnd;Cr&z.sbnd;Ni alloy

Science.gov (United States)

Tanigawa, Hiroyasu; Katoh, Yutai; Kohyama, Akira

1995-08-01

Effects of applied stress on early stages of interstitial type Frank loop evolution were investigated by both numerical calculation and irradiation experiments. The final objective of this research is to propose a comprehensive model of complex stress effects on microstructural evolution under various conditions. In the experimental part of this work, the microstructural analysis revealed that the differences in resolved normal stress caused those in the nucleation rates of Frank loops on {111} crystallographic family planes, and that with increasing external applied stress the total nucleation rate of Frank loops was increased. A numerical calculation was carried out primarily to evaluate the validity of models of stress effects on nucleation processes of Frank loop evolution. The calculation stands on rate equuations which describe evolution of point defects, small points defect clusters and Frank loops. The rate equations of Frank loop evolution were formulated for {111} planes, considering effects of resolved normal stress to clustering processes of small point defects and growth processes of Frank loops, separately. The experimental results and the predictions from the numerical calculation qualitatively coincided well with each other.

Frank Close presents his book "Neutrino" and a forthcoming book on Bruno Pontecorvo

CERN Multimedia

2013-01-01

Frank Close's book "Neutrino" is short listed for the Italian Galileo Prize. Frank describes how he was inspired to write about Ray Davis' heroic quest to do what many thought was impossible: detecting neutrinos from the sun. He will also describe how he has, in turn, become fascinated by the life and work of "Mr Neutrino" - Bruno Pontecorvo - and is writing a biography of him.   By choosing to move to the USSR suddenly in 1950, Pontecorvo missed out on getting full credit for several seminal ideas about neutrinos including, possibly, their discovery. Why he went to the USSR so suddenly has been unresolved for 60 years. Frank's book "A Life of Two Halves" may answer this question, in 2014. He will update on progress so far. Wednesday 17 April at 4 p.m. in the Library, 52-1-052 Tea and coffee will be served from 3:30 p.m. Here on Indico.

78 FR 45288 - Frank Sherman, Evergreen Trails, Inc., Cabana Coaches, LLC, TMS West Coast, Inc. and FSCS...

Science.gov (United States)

2013-07-26

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [STB Docket No. MCF 21054] Frank Sherman, Evergreen Trails, Inc., Cabana Coaches, LLC, TMS West Coast, Inc. and FSCS Corporation--Intra-Corporate Family Transaction Exemption Frank Sherman, Evergreen Trails, Inc. (Evergreen), Cabana Coaches, LLC...

La arquitectura tardía de Frank Lloyd Wright, el primer maestro moderno

OpenAIRE

González Capitel, Antón

1996-01-01

1. La arquitectura tardía de Frank Lloyd Wright, el primer maestro moderno l. l. Un Wright renovado. Talleres y residencias l. l. l. Nuevas casas de Wright en su segunda «edad de oro»: un neoplasticismo orgánico en la casa de la Cascada l. l. 2. Geometrías y disposiciones alternativas l. 2. Arquitectura y ciudad orgánicas 1. 2. 1. El desarrollo de la arquitectura orgánica 1. 3. Arquitecturas relacionadas con la de Frank Lloyd Wright entre los emigrados europeos: Schindler y...

78 FR 47217 - Proposed Supervisory Guidance on Implementing Dodd-Frank Act Company-Run Stress Tests for Banking...

Science.gov (United States)

2013-08-05

... 10-50. More advanced portfolio segmentation can take several forms, such as by product (construction... CORPORATION 12 CFR Part 325 Proposed Supervisory Guidance on Implementing Dodd-Frank Act Company-Run Stress... 165(i)(2) of the Dodd-Frank Act Wall Street Reform and Consumer Protection Act (``DFA'') stress tests...

Nietzsche contra Superman: An Examination of the work of Frank ...

African Journals Online (AJOL)

This paper investigates the work of Frank Miller, particularly his Batman: The Dark Knight Returns, in light of Nietzschean aesthetics and social commentary. A graphic novelist, and thus nominally an entertainer of the masses, Miller uses the comic medium to challenge, aesthetically and intellectually. Batman: The Dark ...

75 FR 62718 - Disclosure for Asset-Backed Securities Required by Section 943 of the Dodd-Frank Wall Street...

Science.gov (United States)

2010-10-13

... Putting Banks in Hole,'' Wall Street Journal (Mar. 8, 2010) (noting that most mortgages put back to... Dodd-Frank Wall Street Reform and Consumer Protection Act AGENCY: Securities and Exchange Commission. ACTION: Proposed rule. SUMMARY: Pursuant to Section 943 of the Dodd-Frank Wall Street Reform and Consumer...

The Impact of the Dodd-Frank Act on Financial Stability and Economic Growth

Directory of Open Access Journals (Sweden)

Martin Neil Baily

2017-01-01

Full Text Available This article assesses the benefits and costs of key provisions of the Dodd-Frank Act that strengthened regulation following the financial crisis. The provisions are placed into five groupings: clear wins, clear losses, costly tradeoffs, unfinished business, and too soon to tell. Clear wins include higher prudential standards, including for capital; the single-point-of-entry resolution authority; creation of the Consumer Financial Protection Bureau; and greater transparency and oversight of derivatives. Clear losses are restrictions on Federal Reserve emergency lending authority and forcing the Federal Deposit Insurance Corporation to obtain permission from Congress before providing temporary liquidity guarantees. Costly tradeoffs are the Volcker Rule and the Lincoln Amendment. Unfinished business includes regulatory consolidation and more independence for the Financial Stability Oversight Council and the Office of Financial Research. Too soon to tell are requirements and standards for leverage ratios, capital buffers, stress testing, and liquidity requirements.

On the Connection between Kinetic Monte Carlo and the Burton-Cabrera-Frank Theory

Science.gov (United States)

Patrone, Paul; Margetis, Dionisios; Einstein, T. L.

2013-03-01

In the many years since it was first proposed, the Burton- Cabrera-Frank (BCF) model of step-flow has been experimentally established as one of the cornerstones of surface physics. However, many questions remain regarding the underlying physical processes and theoretical assumptions that give rise to the BCF theory. In this work, we formally derive the BCF theory from an atomistic, kinetic Monte Carlo model of the surface in 1 +1 dimensions with one step. Our analysis (i) shows how the BCF theory describes a surface with a low density of adsorbed atoms, and (ii) establishes a set of near-equilibrium conditions ensuring that the theory remains valid for all times. Support for PP was provided by the NIST-ARRA Fellowship Award No. 70NANB10H026 through UMD. Support for TLE and PP was also provided by the CMTC at UMD, with ancillary support from the UMD MRSEC. Support for DM was provided by NSF DMS0847587 at UMD.

Sirkusbaas Frank Fillis (1857-1921): die Barnum van Suid-Afrika ...

African Journals Online (AJOL)

He was born in London in 1857 and died in Bangkok in 1921. He came to South Africa in 1880 and for ... This article deals with a number of new facts, as well as aspects such as his popularity, talent as entertainer, his kindness, poor business sense and the social impact of his circus. Frank Fillis: Die Barnum van Suid-Afrika

76 FR 11935 - Death of Army Corporal Frank W. Buckles, the Last Surviving American Veteran of World War I

Science.gov (United States)

2011-03-03

... of Army Corporal Frank W. Buckles, the Last Surviving American Veteran of World War I By the... Corporal Frank W. Buckles, the last surviving American veteran of World War I, and in remembrance of the generation of American veterans of World War I, I hereby order, by the authority vested in me by the...

Digital Documentation of Frank Lloyd Wright's Masterpiece, Fallingwater

Science.gov (United States)

Jerome, P.; Emilio, D.

2017-08-01

Since 1988, the professional staff of Architectural Preservation Studio (APS) has been involved with the conservation of Frank Lloyd Wright's Fallingwater in Mill Run, PA. Designed and erected from 1935 to 1939 as a weekend home for the Kauffman family, the complex consists of the main house and guest house. After five years of reports and prototype repairs, we produced a two-volume master plan. Using original Frank Lloyd Wright drawings from Avery Library as background drawings, we measured every surface and reproduced the drawings in CAD, also developing elevations of every room. Stone-by-stone drawings of every flagstone floor and terrace scheduled to be lifted were also created using overlapping film photography that was assembled into a photo mosaic. By 2005, we designed, administered and completed a four-phase exterior restoration, with the paint-stripping and repainting of interior rooms being performed during the brief winter period when the building is closed to the public on an ongoing basis. In 2016, we were invited back to the site to review conditions and advise on routine maintenance. At that time we proposed to re-document the buildings, this time using laser-scanning. Laser-scanning of the exterior was performed in May of 2016, and of the interior in March 2017, each over the course of four days. This paper will make a comparison between manual and digital techniques in terms of Fallingwater's documentation.

Effect of radiation on the critical Frank – Kamenetskii parameter of ...

African Journals Online (AJOL)

We investigate the effect radiation on the critical Frank-Kamenetskii parameter of thermal ignition in a combustible gas containing fuel droplets (furnaces, gas turbines and internal combustion engines). Previous works show that radiation delays ignition in a well stirred reactor. In this paper we show that, even in a ...

Frank Lloyd Wright - väike maja saab suureks : meistriklass / Pille Nagel

Index Scriptorium Estoniae

Nagel, Pille

2006-01-01

Frank Lloyd Wrighti (1867-1959) eramuloomingust. Preeriamajadest, usonia majadest, krundist ja maastikust algavast arhitektuurist, katustest ja horisontaalsusest, plaanist, tasapindade ja kõrguste muutumistest, akendest, autovarjualustest, materjalidest ja värvidest, privaatsusest ja avatusest, inimlikust mõõtmest jm. 11 värv. vaadet, plaan

Lead and copper removal from aqueous solutions by porous glass derived calcium hydroxyapatite

International Nuclear Information System (INIS)

Liang Wen; Zhan Lei; Piao Longhua; Ruessel, Christian

2011-01-01

Graphical abstract: . Adsorption of Pb 2+ increases with the increase in NaCl volume percentage (1:0%, 2:30%, 3:40%, 4:40%) of the Glass Derived Hydroxyapatite and reaches equilibrium after 24 h. Highlights: → Novel porous glass derived hydroxyapatite matrix is prepared. → Glass derived hydroxyapatite matrix adsorbs lead and copper ions in solutions effectively. → Two adsorption mechanisms including ion exchange theory and the dissolution and precipitation theory are involved in removal of the heavy metal ions from the solutions. - Abstract: A porous glass was prepared by sintering Na 2 O-CaO-B 2 O 3 glass powder with powdered sodium chloride. Subsequently, the sodium chloride was dissolved in water resulting in a highly porous material. A sample was prepared consisting of 60 vol% glass and 40 vol% salt which both had particle sizes 2 HPO 4 solutions at room temperature for 1 day. The porous glass derived hydroxyapatite matrix was then processed for removing lead and copper ions from aqueous solutions. The results showed that the glass derived calcium hydroxyapatite matrix effectively immobilizes lead and copper ions in solution. The adsorption mechanism was investigated by the X-ray Diffraction (XRD) and Scanning Electron Microscopy including Energy Dispersive X-Ray Spectrometry (SEM-EDX).

76 FR 43549 - Office of Thrift Supervision Integration; Dodd-Frank Act Implementation

Science.gov (United States)

2011-07-21

..., Manager, Disclosure Services and Administrative Operations, Communications Division, (202) 874-5378... abolishes the OTS ninety days after the transfer date. Specifically, the Dodd-Frank Act transfers to the OCC... operation of law.\\3\\ Title III also transfers OTS employees to either the OCC or FDIC, allocated as...

After $74-Million and Counting, Frank Gehry's Library Opens at Princeton

Science.gov (United States)

Carlson, Scott

2008-01-01

In putting up its new, Frank Gehry-designed Lewis Library, Princeton University endured its share of challenges. It constructed models of the building to give the subcontractors a chance to practice. It fired a contractor halfway through the job when the building was past due. It learned that some subcontractors were trying to bribe their way onto…

LA ESTRUCTURA ORGÁNICA EN LOS RASCACIELOS DE FRANK LLOYD WRIGHT / The organic structure in the skyscrapers of Frank Lloyd Wright

Directory of Open Access Journals (Sweden)

Alfonso Diaz Segura, Ricardo Meri de la Maza, Bartolomé Serra Soriano

2013-05-01

Full Text Available RESUMEN La estructura de la modernidad, en general, está al servicio de una nueva concepción espacial fluida y continua, condensada en torno al concepto de “planta libre”. Sin embargo, la riqueza y complejidad de articulación que adquieren las plantas, no se observa en la sección de los edificios, especialmente si se trata de rascacielos. El principio de crecimiento por superposición de plantas iguales y el carácter utilitario de la estructura en esta tipología, anularon su carácter iconográfico y su integración espacial. Frank Lloyd Wright, de modo natural, desarrolla una estructura para sus escasos rascacielos que integra espacio y forma, superando así tanto la simplificación funcional de la Escuela de Chicago, como el valor iconográfico de las experiencias europeas.SUMMARY In general, the structure of modernity serves a new, fluid and continuous, spatial conception, condensed around the “free floor” concept. However, the wealth and complexity of articulation that these floors acquire are not seen in the section of the buildings, especially in the case of skyscrapers. The principle of growth by superimposition of equal floors and the utilitarian character of the structure in this type of building, nullify the iconographic character of the structure and its spatial integration. Frank Lloyd Wright develops a structure for his few skyscrapers that integrates space and form in a natural way, thus surpassing both the functional simplification of the Chicago School, and the iconographic value of the European experiences.

Frank and Fearless: Supporting Academic Career Progression for Women in an Australian Program

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Polly Parker

2018-02-01

Full Text Available The underrepresentation of women in senior positions continues to be a major challenge in higher education and most other industries. In Australia, the career trajectory for academic women stalls at a lower level than that of their male counterparts. Concern about this situation in one Australian university led to the design and delivery of a career progression program to support women’s advancement from senior lecturer to associate professor. This study details the main features of the program, designed to facilitate women’s transition from being leading academics to academic leaders through a focus on leadership and career progression. We report the participants’ perceptions of its value based on survey data. We conclude that leadership development is difficult work and requires a supportive environment where risk-taking is encouraged, where frank and fearless feedback is provided, and where the individual is required to examine assumptions and biases and to assume a leadership identity.

Andrij Makuch and Frank E. Sysyn, editors. Contextualizing the Holodomor: The Impact of Thirty Years of Ukrainian Famine Studies

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Johnathon Vsetecka

2017-03-01

Full Text Available Book review of Andrij Makuch and Frank E. Sysyn, editors. Contextualizing the Holodomor: The Impact of Thirty Years of Ukrainian Famine Studies. Canadian Institute of Ukrainian Studies P, 2015. viii, 128 pp. $24.95, paper. Conference papers first published in East/West: Journal of Ukrainian Studies, editor-in-chief, Oleh S. Ilnytzkyj, guest editors, Frank Sysyn and Andrij Makuch, vol. 2, no. 1, 2015, pp. 3-132.

Looking and Learning: The Solomon R. Guggenheim Museum, Frank Lloyd Wright

Science.gov (United States)

Vatsky, Sharon

2007-01-01

Frank Lloyd Wright was born and raised on the farmlands of Wisconsin. His mother had a vision that her son would become a great architect. Wright was raised with strong guiding principles, a love of nature, a belief in the unity of all things, and a respect for discipline and hard work. He created the philosophy of "organic architecture," which…

Barbarid, plastiliinijänes, Miriam ja Frank Muller / Annika Koppel

Index Scriptorium Estoniae

Koppel, Annika

2003-01-01

Nukufilm näitab 4 uut filmi : "Barbarid" (stsenaristid Andrus Kivirähk ja Hardi Volmer, režissöör H. Volmer), "Porgand" (stsenarist Peep Pedmanson, režissöör Pärtel Tall), "Miriami jõulupäkapikk" (stsenaristid Leelo Tungal ja Peep Pedmanson, režissöör Mait Laas), "Kuuvaatleja" (reklaamitreiler Frank Mulleri kellafirmale ; stsenarist, režissöör, kunstnik Mati Kütt)

A new RF tagging pulse based on the Frank poly-phase perfect sequence

DEFF Research Database (Denmark)

Laustsen, Christoffer; Greferath, Marcus; Ringgaard, Steffen

2014-01-01

Radio frequency (RF) spectrally selective multiband pulses or tagging pulses, are applicable in a broad range of magnetic resonance methods. We demonstrate through simulations and experiments a new phase-modulation-only RF pulse for RF tagging based on the Frank poly-phase perfect sequence...

Poesia y Pintura: Frank O'Hara y el expresinionismo abstracto

OpenAIRE

Alberto Santamaría

2015-01-01

El objetivo de este artículo es analizar las relaciones entre poesía y pintura en el seno del expresionismo abstracto. Para ello tomamos tres nombres de referencia: Clement Greenberg (crítico de arte), Frank O'Hara (poeta) y Willem De Kooning (pintor). A través de estos nombres tratamos de señalar la estrecha relación que existía entre poetas y pintores en la llamada Escuela de Nueva York.

The core structure of a Frank dislocation in Ni3(Al,Nb)

International Nuclear Information System (INIS)

Bonnet, R.; Loubradou, M.; Derder, C.; Catana, A.

1991-01-01

This paper reports on the core structures of dislocations in L1 2 crystals, in view of understanding the anomalous yield behavior of strength with increasing temperature. Theoretical approaches have been proposed for explaining the dissociations of these dislocations, and experimental evidences have been reported for such dissociations using either the weak beam technique or more recently the HRTEM (High Resolution Transmission Electron Microscopy) technique. Recent HRTEM results show that for Ni 3 A1 the partial dislocations 1/2 left-angle 110 right-angle which limit an APB (Antiphase Boundary) lying on (001) are only split over 0.1 - 0.3 nm along (111) planes, producing very high energy CSF's (Complex Stacking Faults) which limit an SISF (superlattice Intrinsic Stacking Fault) extended on a (111) plane. Concerning the 1/2 left-angle 111 right-angle Frank dislocation, which limits an SESF (Superlattice Extrinsic Stacking Fault), there are no reported results yet. Let us note, however, that for aluminum HRTEM images of Frank dislocation loops have been studied. This lack of information in the L1 2 crystals motivated the present HRTEM study

"Frank ja Wendy" rikub jõulud ja võtab söögiisu / Astrid Kannel

Index Scriptorium Estoniae

Kannel, Astrid, 1967-

2004-01-01

Animafilm "Frank ja Wendy" : autor David Snowman = Priit Pärn, Ülo Pikkov, Priit Tender ja Kaspar Jancis : Eesti Joonisfilm 2004. Kõik autorid vastavad midagi artikli autori provotseerivatele küsimustele

Exploration of Novel Botanical Insecticide Leads: Synthesis and Insecticidal Activity of β-Dihydroagarofuran Derivatives.

Science.gov (United States)

Zhao, Ximei; Xi, Xin; Hu, Zhan; Wu, Wenjun; Zhang, Jiwen

2016-02-24

The discovery of novel leads and new mechanisms of action is of vital significance to the development of pesticides. To explore lead compounds for botanical insecticides, 77 β-dihydroagarofuran derivatives were designed and synthesized. Their structures were mainly confirmed by (1)H NMR, (13)C NMR, DEPT-135°, IR, MS, and HRMS. Their insecticidal activity was evaluated against the third-instar larvae of Mythimna separata Walker, and the results indicated that, of these derivatives, eight exhibited more promising insecticidal activity than the positive control, celangulin-V. Particularly, compounds 5.7, 6.6, and 6.7 showed LD50 values of 37.9, 85.1, and 21.1 μg/g, respectively, which were much lower than that of celangulin-V (327.6 μg/g). These results illustrated that β-dihydroagarofuran ketal derivatives can be promising lead compounds for developing novel mechanism-based and highly effective botanical insecticides. Moreover, some newly discovered structure-activity relationships are discussed, which may provide some important guidance for insecticide development.

Landau–De Gennes Theory of Nematic Liquid Crystals: the Oseen–Frank Limit and Beyond

KAUST Repository

Majumdar, Apala

2009-07-07

We study global minimizers of a continuum Landau-De Gennes energy functional for nematic liquid crystals, in three-dimensional domains, subject to uniaxial boundary conditions. We analyze the physically relevant limit of small elastic constant and show that global minimizers converge strongly, in W1,2, to a global minimizer predicted by the Oseen-Frank theory for uniaxial nematic liquid crystals with constant order parameter. Moreover, the convergence is uniform in the interior of the domain, away from the singularities of the limiting Oseen-Frank global minimizer. We obtain results on the rate of convergence of the eigenvalues and the regularity of the eigenvectors of the Landau-De Gennes global minimizer. We also study the interplay between biaxiality and uniaxiality in Landau-De Gennes global energy minimizers and obtain estimates for various related quantities such as the biaxiality parameter and the size of admissible strongly biaxial regions. © Springer-Verlag (2009).

Landau–De Gennes Theory of Nematic Liquid Crystals: the Oseen–Frank Limit and Beyond

KAUST Repository

Majumdar, Apala; Zarnescu, Arghir

2009-01-01

We study global minimizers of a continuum Landau-De Gennes energy functional for nematic liquid crystals, in three-dimensional domains, subject to uniaxial boundary conditions. We analyze the physically relevant limit of small elastic constant and show that global minimizers converge strongly, in W1,2, to a global minimizer predicted by the Oseen-Frank theory for uniaxial nematic liquid crystals with constant order parameter. Moreover, the convergence is uniform in the interior of the domain, away from the singularities of the limiting Oseen-Frank global minimizer. We obtain results on the rate of convergence of the eigenvalues and the regularity of the eigenvectors of the Landau-De Gennes global minimizer. We also study the interplay between biaxiality and uniaxiality in Landau-De Gennes global energy minimizers and obtain estimates for various related quantities such as the biaxiality parameter and the size of admissible strongly biaxial regions. © Springer-Verlag (2009).

The Nation behind the Diary: Anne Frank and the Holocaust of the Dutch Jews

Science.gov (United States)

Foray, Jennifer L.

2011-01-01

Since its first appearance in 1947, "The Diary of Anne Frank" has been translated into sixty-five different languages, including Welsh, Esperanto, and Faroese. Millions and perhaps even billions of readers, scattered throughout the globe and now spanning multiple generations, are familiar with the life and work of this young Jewish…

Testing of Frank's hypothesis on a containerless packing of macroscopic soft spheres and comparison with mono-atomic metallic liquids

International Nuclear Information System (INIS)

Sahu, K.K.; Wessels, V.; Kelton, K.F.; Loeffler, J.F.

2011-01-01

Highlights: → Testing of Frank's hypothesis for Centripetal Packing (CP) has been proposed. → It is shown that CP is an idealized model for Monatomic Supercooled Liquid (MSL). → The CP is fit for comparing with studies on MSL in a containerless environment. → We measure local orders in CP by HA and BOO methods for the first time. → It is shown that icosahedral order is greater in CP than MSL and reasons explored. - Abstract: It is well-known that metallic liquids can exist below their equilibrium melting temperature for a considerable time. To explain this, Frank proposed that icosahedral ordering, incompatible with crystalline long-range order, is prevalent in the atomic structure of these liquids, stabilizing them and enabling them to be supercooled. Some studies of the atomic structures of metallic liquids using Beam-line Electrostatic Levitation (BESL; containerless melting), and other techniques, support this hypothesis . Here we examine Frank's hypothesis in a system of macroscopic, monodisperse deformable spheres obtained by containerless packing under the influence of centripetal force. The local structure of this packing is analyzed and compared with atomic ensembles of liquid transition metals obtained by containerless melting using the BESL method.

Understanding and Teaching Students with Emotional-Behavioral Disorders: A Conversation with Frank H. Wood

Science.gov (United States)

Zabel, Robert; Kaff, Marilyn; Teagarden, Jim

2011-01-01

Frank H. Wood is both a pioneer and a first-generation leader, and his contributions continue to influence the field today. Dr. Wood participated in several "firsts." In the 1950s, he taught the first public school class in Minnesota for emotionally disturbed students, and he later served as the first coordinator of programs for students…

Palaeopathology of the earlobe crease (Frank's sign): New insights from Renaissance art.

Science.gov (United States)

Galassi, Francesco M; Borghi, Claudio; Ballestriero, Roberta; Habicht, Michael E; Henneberg, Maciej; Rühli, Frank J

2017-06-01

Several studies have associated the earlobe crease sign, discovered by Sanders T. Frank in 1973, with cardiovascular pathology, yet very few studies have focused on the antiquity of this trait, with the most ancient one thought to date back to the Roman Emperor Hadrian (76-138CE). This article presents two more cases from the Italian Renaissance in the works of the artist Andrea Mantegna (1431-1506) and examines them in a multidisciplinary fashion. Copyright © 2017 Elsevier B.V. All rights reserved.

Diversity between Panels of the Franks Casket – Spelling and Runic Paleography

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Helena Sobol

2017-10-01

Full Text Available The Franks Casket, a small whalebone box from about 700 AD, contains 59 Old English words inscribed in runes. Systematic differences between its panels have never called into question the standard procedure of explaining one panel basing on the others. The present paper aims at a re-examination of the validity of this approach. The panels show a large enough differentiation of spelling and paleographical features to exclude the possibility of a single author for the whole Casket.

Frank-ter Haar syndrome protein Tks4 regulates epidermal growth factor-dependent cell migration.

Science.gov (United States)

Bögel, Gábor; Gujdár, Annamária; Geiszt, Miklós; Lányi, Árpád; Fekete, Anna; Sipeki, Szabolcs; Downward, Julian; Buday, László

2012-09-07

Mutations in the SH3PXD2B gene coding for the Tks4 protein are responsible for the autosomal recessive Frank-ter Haar syndrome. Tks4, a substrate of Src tyrosine kinase, is implicated in the regulation of podosome formation. Here, we report a novel role for Tks4 in the EGF signaling pathway. In EGF-treated cells, Tks4 is tyrosine-phosphorylated and associated with the activated EGF receptor. This association is not direct but requires the presence of Src tyrosine kinase. In addition, treatment of cells with LY294002, an inhibitor of PI 3-kinase, or mutations of the PX domain reduces tyrosine phosphorylation and membrane translocation of Tks4. Furthermore, a PX domain mutant (R43W) Tks4 carrying a reported point mutation in a Frank-ter Haar syndrome patient showed aberrant intracellular expression and reduced phosphoinositide binding. Finally, silencing of Tks4 was shown to markedly inhibit HeLa cell migration in a Boyden chamber assay in response to EGF or serum. Our results therefore reveal a new function for Tks4 in the regulation of growth factor-dependent cell migration.

A Novel is a Lengthy Question: An Interview with Frank Ronan

OpenAIRE

Valentina Milli

2007-01-01

Frank Ronan has published a collection of short stories, Handsome Men Are Slightly Sunburnt (1996), and six novels, The Men Who Loved Evelyn Cotton(1989), A Picnic in Eden (1991), The Better Angel (1992), Dixie Chicken (1994), Lovely (1996) and Home (2002), many of which have been translated into French, Spanish, German, Portuguese, Italian, Greek and Dutch. It is extremely difficult to pigeonhole Ronan’s writing and, according to him, it is also pointless since “it’s always the people who do...

Religious Foundations of Culture (The Controversy Between Simon Frank and Simon Lurie on “Vekhi”

Directory of Open Access Journals (Sweden)

Gennadii Aliaiev

2016-02-01

Full Text Available The author analyses discussion that took place between S. Frank and S. Lurje concerning “Vekhi” (“Landmarks”. In this context, the author’s objective is to show the evolution of S. Frank’s outlook on culture and religion, which developed in three stages: the humanistic individualism, the religious humanism, and the Christian realism.

William Franke, Sulla verità poetica che è superiore alla Storia: Porfirio e la critica filosofica della letteratura William Franke, On the Poetic Truth that is Higher than History: Porphyry and the Philosophical Interpretation of Literature

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Laura Lucia Rossi

2010-06-01

Full Text Available

Interpretation of recovery Stage III in gold: a comment on the paper of A. Seeger and W. Frank

Energy Technology Data Exchange (ETDEWEB)

Sonnenberg, K.; Dedek, U.; Ehrhart, P.; Schilling, W. (Kernforschungsanlage Juelich G.m.b.H. (Germany, F.R.). Inst. fuer Festkoerperforschung)

1983-09-01

The attempt of Seeger and Frank to reinterpret the annealing in recovery Stage III in gold in terms of the mobile single interstitial is discussed. Considering the experimental data of Stage III in irradiated samples and for the annealing stage observed in quenching samples around room temperature, it is concluded that the assignment of the recovery in these two stages to two different elementary defects is unjustified. It is further demonstrated that the interpretation of recovery Stage III by interstitial migration is in conflict with the direct observations of vacancies migrating in this stage and that the interpretation of the recovery measurements in radiation doped gold by the two interstitial model leads to inconsistencies. The attempt to interpret recovery Stage III in gold by interstitial migration must therefore be rejected and the activation energy of 0.71 eV measured for this stage must be attributed to the migration energy of single vacancies.

Effect of volume loading on the Frank-Starling relation during reductions in central blood volume in heat-stressed humans

DEFF Research Database (Denmark)

Bundgaard-Nielsen, Morten; Wilson, T E; Seifert, Thomas

2010-01-01

During reductions in central blood volume while heat stressed, a greater decrease in stroke volume (SV) for a similar decrease in ventricular filling pressure, compared to normothermia, suggests that the heart is operating on a steeper portion of a Frank-Starling curve. If so, volume loading...... of heat-stressed individuals would shift the operating point to a flatter portion of the heat stress Frank-Starling curve thereby attenuating the reduction in SV during subsequent decreases in central blood volume. To investigate this hypothesis, right heart catheterization was performed in eight males...... from whom pulmonary capillary wedge pressure (PCWP), central venous pressure and SV (via thermodilution) were obtained while central blood volume was reduced via lower-body negative pressure (LBNP) during normothermia, whole-body heating (increase in blood temperature 1 degrees C), and during whole...

Spatial History e humanidades digitais, uma entrevista com o brasilianista Zephyr Frank

Directory of Open Access Journals (Sweden)

FREDERICO FREITAS

2014-04-01

Full Text Available Resumo: Entrevista com Zephyr Frank, diretor do Spatial History Project (Projeto de História Espacial e do Center for Spatial and Textual Analysis (Centro de Análise Espacial e Textual da Universidade Stanford, nos Estados Unidos, sobre spatial history e outras linhas de pesquisa englobadas sob o rótulo das humanidades digitais. A discussão toca o tema do uso de novos métodos digitais como o SIG histórico, a leitura à distância e a análise de redes sociais na pesquisa em humanidades, questionando os limites e as possibilidades de tais ferramentas. Por fim, discute-se sobre o investimento institucional e financeiro necessário para a implementação dessas novas tecnologias de pesquisa.Palavras-chave: Spatial History – Humanidades Digitais – Redes Sociais – Leitura à Distância. Abstract: An interview with Zephyr Frank, director of both the Spatial History Project and the Center for Spatial and Textual Analysis at Stanford University, on spatial history and other lines of research encompassed by the digital humanities label. The discussion touches on the new digital methods of research like historical GIS, distant reading, and social network analysis, which are becoming more common among humanists. It also questions the possibilities and limits of such tools. Finally, it presents a brief discussion on the institutional and financial resources needed for implementing those new research technologies.Keywords: Spatial History – Digital Humanities – Social Networks – Distant Reading.

An inevitable end? The collapse of the Lombard kingdom facing the Franks and the papacy

Directory of Open Access Journals (Sweden)

Stefano Gasparri

2016-09-01

Full Text Available According to the Italian historiography, from Alessandro Manzoni (1822 to the two major Italian historians who studied the Lombards at the middle of the twentieth century, Gian Piero Bognetti and Ottorino Bertolini, the Lombards remained always separated from the Roman population, of which the pope was the natural leader; the Lombards, too, became very late Catholics, in time, though, to experience the "drama" of having to fight against the pope, whose supreme spiritual authority the Lombards themselves at that point recognized. Consequently, the fall of the independent kingdom by the hands of the Franks would be logical and inevitable. This is an old and outdated position: the end of the independent Lombard kingdom wasn’t inevitable. At the time of the Frankish conquest, the kingdom was politically solid inward, in economic growth and very dynamic outward. During the reigns of Liutprand, Ratchis and Aistulf (712-757, the kingdom exercised its hegemony over the whole Italy. In this period no strong elements of internal weakness emerged. Therefore, the defeat of 774 was substantially caused by external factors, ie the alliance between the Franks and the papacy. However, the attitude of the popes against the Lombard kingdom was not always hostile. Things changed only with Stephen II, because of two simultaneous events occurring in 751: the royal anointing of Pepin in the Frankish kingdom and the conquest of the Exarchate by Aistulf. Italian political balance broke and caused the decisive rapprochement between Rome and the Franks. But there were still many uncertainties, as proved, for example, by Charlemagne’s marriage with a daughter of Desiderius. Carloman’s death in 771 and, the following year, the election of the new pope Adrian I caused the repudiation of the Lombard bride by Charlemagne, his descent into Italy in 773, and the capture of Pavia the year after: Desiderius was exiled in France and Charlemagne became rex Langobardorum. The

Edgar Frank Codd e o Banco de Dados Relacional: uma contribuição para a História da Computação

OpenAIRE

Souza, Odécio

2015-01-01

No presente ensaio, pretendemos analisar a participação de Edgar Frank Ted Codd na organização das bases teóricas que permitiram a criação do "Objeto Tecnológico" conhecido como "Sistema Gerenciador de Banco de Dados Relacional", oferecendo assim uma contribuição para a História da Computação In this essay, we intend to analyze the participation of Edgar Frank "Ted" Codd in the organization of the theoretical foundations that allowed the creation of the "Technologica...

Reply in response to comment by E. W. Hones. [concerning the paper, on hot tenuous plasmas, fireballs, and boundary layers in the earth's magnetotail by Frank, et al.

Science.gov (United States)

Frank, L. A.; Decoster, R. J.; Ackerson, K. L.

1977-01-01

Hones 1977 points out the marked disagreement between the plasma flow measurements reported by Frank et al. 1976 and those obtained with the LASL plasma analyzer. He suggests (1) that solar ultraviolet background rates may have been incorrectly accounted for in the computation of proton bulk flows in the magnetotail as reported by Frank et al. 1976 and (2) that bulk flows with substantial speeds, i.e., those speeds greater than 50 km per sec, are seldom encountered in the plasma sheet at geocentric radial distances approx. equal to 35 R sub E. It is demonstrated that such ultraviolet responses were carefully considered by Frank et al. 1976 and thus the conclusion is maintained that bulk flows greater than 50 km per sec frequently occur in the plasma sheet at these radial distances. Further, a direct comparison of the capabilities of the LASL plasma analyzer employed by Hones and of the LEPEDEA Frank et al., 1976 indicates that there are rather severe restrictions on which plasmas in the plasma sheet can be properly measured to gain proton temperatures, number densities and flow velocities with the LASL plasma analyzer.

Pressure derivatives of the second-order elastic constants of strontium, barium, and lead nitrate

International Nuclear Information System (INIS)

Bedi, S.S.; Verma, M.P.

1980-01-01

An interpretation is given of the measured results on the pressure derivatives of second-order elastic constants (SOEC) of strontium barium, and lead nitrate crystallizing in the fluorite type structure from the Lundquist potential. Potential parameters are determined from the experimental values of SOEC and the equilibrium condition

76 FR 48949 - Office of Thrift Supervision Integration Pursuant to the Dodd-Frank Wall Street Reform and...

Science.gov (United States)

2011-08-09

... accounts from the HOLA. Section 157.14 provided that savings associations could pay interest only on.... Section 1046 of the Dodd-Frank Act provides that the Home Owners' Loan Act (HOLA) does not occupy the... a court or by the OCC under the HOLA with respect to Federal savings associations must be made in...

Ophthalmic findings in Frank-ter Haar syndrome: report of a sibling pair.

Science.gov (United States)

Chang, Ta C; Bauer, Mislen; Puerta, Herminia S; Greenberg, Matthew B; Cavuoto, Kara M

2017-12-01

Frank-ter Haar syndrome (FTHS) is an autosomal recessive disorder characterized by abnormalities that affect the development of bone, heart, and eyes. We report a sibling pair with FTHS caused by a homozygous, novel mutation pLys133Glnfs*13 in the SH3PXD2B gene: one sibling had bilateral ocular hypertension and unilateral colobomas of iris, choroid and retina; the other, unilateral myelinated nerve fiber layer of the optic disk and papilledema due to idiopathic intracranial hypertension. Both children had refractive amblyopia and megalocornea. Copyright © 2017 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.

Study and application of the balloon frame system to the industrialization of housing: the case of the American System-Built Houses of Frank Lloyd Wright

Directory of Open Access Journals (Sweden)

B. Serra Soriano

2017-06-01

Full Text Available Within his large architectural production, Frank Lloyd Wright had the opportunity to experiment with the timber industrialization, linking a traditional material with the modern sense of architecture. Wood and Frank Lloyd Wright are inseparable from the balloon frame system, a system which he will use at his first housing and through which he will materialize the spatial decomposition concept. The research on the particular American System-Built Houses case will serve to show the earliest experiences of Wright with the industry, whose conclusions he would use for subsequent researches on prefabrication.

Original and Derived Judgment

DEFF Research Database (Denmark)

Foss, Kirsten; Foss, Nicolai Juul; Klein, Peter G.

2007-01-01

Recent work links entrepreneurship to the economic theory of the firm, using the concept of entrepreneurship as judgment introduced by Frank Knight. When judgment is complementary to other assets, it makes sense for entrepreneurs to hire labour and to own assets. The entrepreneur's role, then...... to subordinates, who exercise derived judgment. We call these employees `proxy-entrepreneurs', and ask how the firm's organizational structure - its formal and informal systems of rewards and punishments, rules for settling disputes and renegotiating agreements, means of evaluating performance and so on - can...... be designed to encourage forms of proxy entrepreneurship that increase firm value while discouraging actions that destroy value. Building on key ideas from the entrepreneurship literature, Austrian economics and the economic theory of the firm, we develop a framework for analysing the trade-off between...

The Oseen-Frank Limit of Onsager's Molecular Theory for Liquid Crystals

Science.gov (United States)

Liu, Yuning; Wang, Wei

2018-03-01

We study the relationship between Onsager's molecular theory, which involves the effects of nonlocal molecular interactions and the Oseen-Frank theory for nematic liquid crystals. Under the molecular setting, we prove the existence of global minimizers for the generalized Onsager's free energy, subject to a nonlocal boundary condition which prescribes the second moment of the number density function near the boundary. Moreover, when the re-scaled interaction distance tends to zero, the global minimizers will converge to a uniaxial distribution predicted by a minimizing harmonic map. This is achieved through the investigations of the compactness property and the boundary behaviors of the corresponding second moments. A similar result is established for critical points of the free energy that fulfill a natural energy bound.

Depth distribution of Frank loop defects formed in ion-irradiated stainless steel and its dependence on Si addition

Energy Technology Data Exchange (ETDEWEB)

Chen, Dongyue, E-mail: dychen@safety.n.t.u-tokyo.ac.jp [The University of Tokyo, Department of Nuclear Engineering and Management, School of Engineering, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8656 (Japan); Murakami, Kenta [The University of Tokyo, Nuclear Professional School, School of Engineering, 2-22 Shirakata-Shirane, Tokai-mura, Ibaraki 319-1188 (Japan); Dohi, Kenji; Nishida, Kenji; Soneda, Naoki [Central Research Institute of Electric Power Industry, 2-11-1 Iwado-kita, Komae, Tokyo 201-8511 (Japan); Li, Zhengcao, E-mail: zcli@tsinghua.edu.cn [Tsinghua University, School of Materials Science and Engineering, Beijing 100084 (China); Liu, Li; Sekimura, Naoto [The University of Tokyo, Department of Nuclear Engineering and Management, School of Engineering, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8656 (Japan)

2015-12-15

Although heavy ion irradiation is a good tool to simulate neutron irradiation-induced damages in light water reactor, it produces inhomogeneous defect distribution. Such difference in defect distribution brings difficulty in comparing the microstructure evolution and mechanical degradation between neutron and heavy ion irradiation, and thus needs to be understood. Stainless steel is the typical structural material used in reactor core, and could be taken as an example to study the inhomogeneous defect depth distribution in heavy ion irradiation and its influence on the tested irradiation hardening by nano-indentation. In this work, solution annealed stainless steel model alloys are irradiated by 3 MeV Fe{sup 2+} ions at 400 °C to 3 dpa to produce Frank loops that are mainly interstitial in nature. The silicon content of the model alloys is also tuned to change point defect diffusion, so that the loop depth distribution influenced by diffusion along the irradiation beam direction could be discussed. Results show that in low Si (0% Si) and base Si (0.42% Si) samples the depth distribution of Frank loop density quite well matches the dpa profile calculated by the SRIM code, but in high Si sample (0.95% Si), the loop number density in the near-surface region is very low. One possible explanation could be Si’s role in enhancing the effective vacancy diffusivity, promoting recombination and thus suppressing interstitial Frank loops, especially in the near-surface region, where vacancies concentrate. By considering the loop depth distribution, the tested irradiation hardening is successfully explained by the Orowan model. A hardening coefficient of around 0.30 is obtained for all the three samples. This attempt in interpreting hardening results may make it easier to compare the mechanical degradation between different irradiation experiments.

Mediations on Emergent Occasions: Mad Men, Donald Draper and Frank O’Hara

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Kate Lilley

2012-09-01

Full Text Available Frank O’Hara’s 1957 poetry collection, Meditations in an Emergency, features in Season Two of Mad Men (2008 as a talismanic phrase and object. Pressed into service as Matthew Weiner’s valentine to his returning viewers, the circulation and citation of the book across the season, through different diegetic and extradiegetic levels, aligns poetry, advertising and quality serial television drama as textual modes intent, above all, on creating attachment through feeling. O’Hara’s book is a crucial link in a series of metonymic relays, chain effects and affects, which underwrite Mad Men’s citational poetics to assert its own cultural authority, and the mediating power of television.

A Novel is a Lengthy Question: An Interview with Frank Ronan

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Valentina Milli

2007-03-01

Full Text Available Frank Ronan has published a collection of short stories, Handsome Men Are Slightly Sunburnt (1996, and six novels, The Men Who Loved Evelyn Cotton(1989, A Picnic in Eden (1991, The Better Angel (1992, Dixie Chicken (1994, Lovely (1996 and Home (2002, many of which have been translated into French, Spanish, German, Portuguese, Italian, Greek and Dutch. It is extremely difficult to pigeonhole Ronan’s writing and, according to him, it is also pointless since “it’s always the people who don’t read books who want to categorise them”. The following interview throws some new light on this brilliant contemporary Irish writer and his multifarious areas of interest.

Some considerations in the splitting of interstitial frank loops formed by irradiation

International Nuclear Information System (INIS)

Seshan, K.; Grilhe, J.; Washburn, J.

1975-05-01

The splitting of interstitial loops formed by irradiation is considered in detail. It is shown that they may split to form obtuse--angled single shear faults on the intersecting (111) planes. A detailed description of the splitting is given in which the interstitial Frank loop is viewed as being made up of perfect dislocation loop and two shears. The detailed description is then considered in the context of the formation of complex loops as are observed in quenching and irradiation studies. Experimentally observed geometries are explained viz, triangular loops within hexagonal ones etc. The nucleation of a DC' loop in complex interstitial loop formation is shown to be feasible. DC' has the magnitude of a perfect dislocation loop and encloses an intrinsic shear

The Last Word: An Interview with Frank Pajares--God, the Devil, William James, the Little Prince, and Self-Efficacy

Science.gov (United States)

Bembenutty, Hefer

2007-01-01

This article presents an interview with Frank Pajares, an internationally recognized scholar in the field of motivation and self-efficacy. During the interview, Pajares talked about William James, what he learned from reading "The Little Prince," his self-efficacy beliefs, and his famous speech wherein he spoke of God, the Devil, and solving the…

Holy Terror, Batman! Frank Miller’s Dark Knight and the Superhero as Hardboiled Terrorist

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Daniele Croci

2016-05-01

Full Text Available Conceived in the late thirties as “bold humanist response to Depression-era fears of runaway scientific advance and soulless industrialism” (Morrison 2012, 6, the superhero has flourished as one of the most resilient archetypes of American popular culture. This essay analyses the literary and cultural contaminations that have engendered an unprecedented revision of the paradigm since the 1980s. In particular, it will take into account three graphic novels by American cartoonist Frank Miller (1957 - , one of leading figures of the mainstream comics renaissance, whose ideas have indelibly influenced the artistic development of both medium and genre. The Dark Knight Returns (1986, The Dark Knight Strikes Again (2002 and Holy Terror (2011 constitute an ideal Batman trilogy that charts the character’s evolution as political counterpoint to the perceived crisis of American identity. In this regard, Reaganism and 9/11 are polarized as historical discontinuities triggering the need for a new kind of a criminal (superhero. It will be in fact demonstrated how the novels hybridise the latent generic links to hardboiled pulp novels (R. Chandler, D. Hammet with narrative and aesthetics elements appropriated from the culturally-received concepts of terrorism and terrorists. This fruitful contamination on the one hand “play[s] with reader assumptions about genre” (Baetens and Frey 2015, 46, while on the other hand deconstructs the ideological underpinnings of the archetype, as the moral dichotomy and the alienation of justice from the law.

Substorm processes in the magnetotail - Comments on 'On hot tenuous plasmas, fireballs, and boundary layers in the earth's magnetotail' by L. A. Frank, K. L. Ackerson, and R. P. Lepping

Science.gov (United States)

Hones, E. W., Jr.

1977-01-01

Various theories regarding the magnetotail are reviewed and discussed. These include the work of Dungey (1961) and Eastman et al., (1976) regarding the generation of the magnetotail, Frank et al., (1976) concerning the so-called magnetotail fireball and its characteristics, and Hones et al., (1976 and 1976a) on the formation of a neutral line across the near-earth plasma sheet near the substorm onset. A detailed discussion of a fireball encounter during 0900-1400 UT in April 1974 is presented, noting plasma and magnetic phenomena observed, and magnetic records from the earth. A critique is made by Hones of the interpretation of this fireball made by Frank et al. In an accompanying reply, Frank et al. comment on the observations made by Hones, with attention to the most evident discrepancy between the two theories, i.e., the generation of large closed magnetic loops in the plasma sheet during magnetic substorms.

Synthesis and Antibacterial Evaluation of Novel 3-Substituted Ocotillol-Type Derivatives as Leads

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Yi Bi

2017-04-01

Full Text Available Due to the rapidly growing bacterial antibiotic-resistance and the scarcity of novel agents in development, bacterial infection is still a global problem. Therefore, new types of antibacterial agents, which are effective both alone and in combination with traditional antibiotics, are urgently needed. In this paper, a series of antibacterial ocotillol-type C-24 epimers modified from natural 20(S-protopanaxadiol were synthesized and evaluated for their antibacterial activity. According to the screening results of Gram-positive bacteria (B. subtilis 168 and MRSA USA300 and Gram-negative bacteria (P. aer PAO1 and A. baum ATCC19606 in vitro, the derivatives exhibited good antibacterial activity, particularly against Gram-positive bacteria with an minimum inhibitory concentrations (MIC value of 2–16 µg/mL. The subsequent synergistic antibacterial assay showed that derivatives 5c and 6c enhanced the susceptibility of B. subtilis 168 and MRSA USA300 to chloramphenicol (CHL and kanamycin (KAN (FICI < 0.5. Our data showed that ocotillol-type derivatives with long-chain amino acid substituents at C-3 were good leads against antibiotic-resistant pathogens MRSA USA300, which could improve the ability of KAN and CHL to exhibit antibacterial activity at much lower concentrations with reduced toxicity.

The LHC: a miracle in the making by Frank Close

CERN Multimedia

2008-01-01

After a quarter of a century of dreaming and planning, designing and building, at last we are about to see the LHC completed. Frank Close, Rudolf Peierls Centre for Theoretical Physics, Oxford University, is a former head of CERN’s Communication Group. He recently visted CERN to give lectures to the summer students.Already the excitement is gathering at the prospect of what will be discovered: possibly the Higgs Boson, or supersymmetry, or even things that no one has thought of. The world’s media are already abuzz with anticipation. But I feel that we are getting ahead of ourselves. The visions of the new world will hopefully be tomorrow’s stories; today let’s reflect on what has been achieved at even getting to this point and recall what it was like long ago when the dream began: in those bygone days, were you sure that the LHC would ever be? We all expect it will work, particle physics has a great track record in such thing...

Mechanoelectric feedback does not contribute to the Frank-Starling relation in the rat and guinea pig heart

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D Kelly

2014-12-01

Full Text Available Mechanoelectric feedback (MEF is the process by which mechanical forces on the myocardium can alter its electrical properties. The effect can be large enough to induce ectopic beats or fibrillation. However, the role of MEF at physiological levels of mechanical stress is not clear. We have investigated alteration in action potential morphology in rat and guinea pig ventricle and in rat atrial tissue at levels of stretch near the plateau of the Frank-Starling curve. Stretch of >100 mm.Hg End Diastolic Left Ventricular Pressure (EDLVP or rapidly applied stretch (EDLVP increased by 25 mm.Hg within 100 ms often triggered ectopic beats in isolated rat and guinea-pig hearts. However, ventricular epicardial monophasic action potentials (MAPs recorded during stretch to EDLVP up to 30 mm. Hg showed no consistent changes in action potential duration (at APD20, APD50 or APD80 in either species. MAP recording detected APD prolongation with very small concentrations of 4-AP (10 μM, confirming the discrimination of the recording technique. In isolated rat atrial strips, no changes in intracellular action potential morphology or membrane potential were seen when stretched to levels producing an optimum increase in contractility. We conclude that alteration in action potential morphology with stretch does not contribute to the Frank-Starling relation in ventricle of rat or guinea-pig isolated heart, or in rat atrial tissue.

Lead elimination by ICRF 158 in rats after chronic lead exposure

Energy Technology Data Exchange (ETDEWEB)

Witting, U; Hultsch, E

1981-02-01

Lead elimination by ICRF 158, a lipophilic derivative of ethylene-diaminetetra-acetate (EDTA), was investigated in rats after chronic lead exposure. The animals had received a lead concentration of 550 ppm in their drinking water for 140 days. Subsequent treatment with ICRF 158 for 30 days led to increased mobilization and elimination of incorporated lead, and the lead-induced inhibition of hemosynthesis was removed. ICR 158 produced no renal damage in excess to lead-induced tubular nephrosis. Separate toxicity tests in mice demonstrated that is less toxic than CaNa/sub 2/EDTA. ICRF 158 does not form stable complexes with lead ions in vitro. The mechanism of action of this lipophilic EDTA derivative is compared to that of its hydrophilic correspondent, the chelating agent CaNa/sub 2/EDTA.

Pleuromutilin and its derivatives-the lead compounds for novel antibiotics.

Science.gov (United States)

Tang, Y-Z; Liu, Y-H; Chen, J-X

2012-01-01

Due to the rapid onset of resistance to most antibacterial drugs, research efforts are focusing on new classes of antibacterials with different mechanisms of action from clinically used antibacterials. Pleuromutilin derivatives have received more and more scientific attention for their unique mechanism of action. Two pleuromutilin derivatives, tiamulin and valnemulin have been successfully developed as antibiotics for veterinary use. Retapamulin, another pleuromutilin derivative has been approved for use in humans in April 2007 by Food and Drug Administration (FDA). It has been shown that there is rarely cross-resistance between pleuromutilin derivatives and other antimicrobial agents, and the development of resistance bacterial is still low. This review will demonstrate mechanism of action of pleuromutilin derivatives and reveal the structure-activity relationship (SAR) of pleuromutilin derivatives. Additionally, the pleuromutilin antibacterial derivative agents in the market, such as tiamulin, valnemulin and retapamulin, will be discussed. It is proposed that new antibacterial agents might be developed from pleuromutilin derivatives in the future.

SUSTAINABLE ORIGINS IN ARCHITECTURE OF FRANK LLOYD WRIGHT

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Martina Zbašnik-Senegačnik

2012-10-01

Full Text Available Frank Lloyd Wright is the greatest American architect and oneof the greatest architects the world. His career began at theend of the 19th century, during the great architectural boom inChicago, under the mentorship of Louis Henry Sullivan, fromwhom he adopted and then perfected the concepts of organicarchitecture and the Prairie house. During the Depressionyears, Wright developed a cheaper and simpler variant of thePrairie house: the Usonian house.Wright's architecture is characterised by an entirely newapproach to building design, particularly the design of houses.He reduced the number of rooms by combining their functionsin a large living space with a central fireplace. He used largeglazed areas to connect the external environment of the housewith the interior. The natural environment of the prairie wasthe inspiration for the horizontal lines that characterised hisarchitecture. His buildings are low in height, close to humanscale and with a great feeling for the natural setting in whichthey are built. He selected materials from the surroundingarea and the principal decoration of his architecture was thenatural structure of the material.The paper presents the ideas of organic architecture, thePrairie house, the Usonian house, along with the best examplesof Wright's architecture and the criteria he employed in theselection of materials and construction technologies. Theenvironmental aspect of his philosophy of the use of materialsis considered in the discussion section.Wright may be considered a pioneer of sustainable architecture.

Modern housing design: prefabricated and modular design in Frank Lloyd Wright's architecture

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Ana Tagliari

2011-12-01

Full Text Available This paper investigates the residential architecture of Frank Lloyd Wright, especially the designs which were conceived from an idea of prefabricated, modular, low-cost, and high-scale construction. Wright's organic designs originated from a material-based grid, which at the same time organized and provided freedom to create spaces and forms. This study reviews Wright's work, from his first Midwest designs that relied on brick, through an intermediary phase in California when he made intense use of concrete blocks, until his last phase, the usonian houses, which featured wood paneling. During his early career, the concept and the methodology of Wright's ideas greatly contributed to a better understanding of his architecture, his apprentices and his followers. The economy and rationalization found in the projects reviewed are of great importance as the analysis of historical proposals helps us understand the topic in question.

A PARODIZAÇÃO DA AÇÃO TRÁGICA EM FRANK PIG SAYS HELLO, DE PATRICK McCABE: DRAMA SOCIAL, VIOLÊNCIA E IRREVERÊNCIA

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Sandra Luna

2018-06-01

Full Text Available Publicado em 1992, The Butcher Boy, celebrado romance de Patrick McCabe, logo foi adaptado para o cinema e para o teatro. Em sua forma dramática, intitulada Frank Pig Says Hello, a peça teatraliza as memórias de infância de Frank Pig, ou Piglet, um “menino-porquinho”. A despeito da dimensão trágica dos conflitos existenciais e sociais que modelam a peça de McCabe, sua dramaturgia subverte a conhecida tradição das tragédias e dos dramas sociais por meio da paródia e da ironia, substituindo o pathos trágico por humor e deboche. Fortemente marcada por traços recorrentes na arte pós-moderna, Frank Pig Says Hello apresenta-se como uma peça que, ao desconstruir as formas dramáticas tradicionais, desconstrói também, por via do riso, do sarcasmo e do grotesco, motivos e fatos associados à história da Irlanda, assim como questiona valores hegemônicos da cultura ocidental. O presente estudo analisa a parodização da ação trágica na peça, examinando as relações entre dramaticidade, violência e irreverência estética.

Early educator-supervised student rocketry: The galcit rocket research project, 1936-1939. A tribute to Frank J. Malina

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James, George S.; Winter, Frank H.

Dr. Frank J. Malina, (1912-1981) is best known to members of the International Astronautical Federation and the International Academy of Astronautics for his deep commitment to, and active involvement in, both organizations; to his associates at UNESCO for his leadership in organizing the UNESCO Division of Scientific Research; to members of the art world for his kinetic paintings and editorship of the journal Leonardo; and to aerospace historians for his co-founding, with Dr. Theodore von Karman (1881-1963), of the Jet Propulsion Laboratory with its World War II development of rocket takeoff assist units for aircraft and, after WWII, America's first production sounding rocket, the WAC Corporal. However, Frank Malina has received little recognition from aerospace educators for his equally pioneering efforts on their behalf. This paper highlights Dr. Malina's efforts not only as an early participant in educator-supported student rocketry but also in helping establishing some of the guiding principles of this field of science motivation. As Dr. Malina noted in 1968, upon becoming one of the founding members of the Supervision of Youth Research Experiments (SYRE) subcommittee of the IAF's Education Committee, the fundamental safety and educational ground rules of: (A) qualified supervision, (B) proper safety facilities, and (C) professionally designed equipment, conceived almost fifty years ago, are equally valid to today's supervised youth rocketry space-related experiment educational programs.

Modulation of the Cardiomyocyte Contraction inside a Hydrostatic Pressure Bioreactor: In Vitro Verification of the Frank-Starling Law

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Lorenzo Fassina

2015-01-01

Full Text Available We have studied beating mouse cardiac syncytia in vitro in order to assess the inotropic, ergotropic, and chronotropic effects of both increasing and decreasing hydrostatic pressures. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of those pressure-loaded beating syncytia starting from the video registration of their contraction movement. By this analysis, we have verified the Frank-Starling law of the heart in in vitro beating cardiac syncytia and we have obtained their geometrical-functional classification.

Drawing a different picture with pencil lead as matrix-assisted laser desorption/ionization matrix for fullerene derivatives.

Science.gov (United States)

Nye, Leanne C; Hungerbühler, Hartmut; Drewello, Thomas

2018-02-01

Inspired by reports on the use of pencil lead as a matrix-assisted laser desorption/ionization matrix, paving the way towards matrix-free matrix-assisted laser desorption/ionization, the present investigation evaluates its usage with organic fullerene derivatives. Currently, this class of compounds is best analysed using the electron transfer matrix trans-2-[3-(4-tert-butylphenyl)-2-methyl-2-propenylidene] malononitrile (DCTB), which was employed as the standard here. The suitability of pencil lead was additionally compared to direct (i.e. no matrix) laser desorption/ionization-mass spectrometry. The use of (DCTB) was identified as the by far gentler method, producing spectra with abundant molecular ion signals and much reduced fragmentation. Analytically, pencil lead was found to be ineffective as a matrix, however, appears to be an extremely easy and inexpensive method for producing sodium and potassium adducts.

PERBANDINGAN ASURANSI LAST SURVIVOR DENGAN PENGEMBALIAN PREMI MENGGUNAKAN METODE COPULA FRANK, COPULA CLAYTON, DAN COPULA GUMBEL

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I GEDE DICKY ARYA BRAMANTA

2017-10-01

Full Text Available This study examines about last survivor life insurance with return of premium for married couples with independent and dependent mortality model. By using Frank copula, Clayton copula, Gumbel copula and Indonesian Mortalita Table 2011, the impact of future life dependence on single premiums and annually premium is evaluated. Based on the calculation of premium with a 10 year contract for the insured parties aged 58 years and 55 years with interest rate used 6.5%, the value of insurance premium last survivor with return of premium is more expensive than without return of premium. The greater the dependency, the more expensive the price of the premium.

Frank País García’s Impact On His Generation And The Legacy For New Generations

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Maricel Coloma-Rizo

2016-12-01

Full Text Available Frank País García raises as a symbol of Santiago de Cuba. his revolutionary labor allows him to trascend as a national historical figure with a great impact on his generation. This paper relays on referencies and testimonies of some of País García’s contemporary people. Although he died Young, he left Deep ethic conceptions beneath his revolutionary work: modesty, sensibility, courage, education, a firm carácter, great sense of discipline and organization; all cualities that new generations should assume.

USARSKI, Frank. O Budismo e as outras: Encontros e desencontros entre as grandes religiões mundiais. Aparecida: Ideias & Letras, 2009. 304p. ISBN 978-85-7698-053-7

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Elisangela Marina de Freitas e Silva

2012-01-01

Full Text Available Resenha do livro USARSKI, Frank. O Budismo e as outras: Encontros e desencontros entre as grandes religiões mundiais. Aparecida: Ideias & Letras, 2009. 304p.ISBN 978-85-7698-053-7

Risk, uncertainty and prophet: The psychological insights of Frank H. Knight

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Tim Rakow

2010-10-01

Full Text Available Economist Frank H. Knight (1885--1972 is commonly credited with defining the distinction between decisions under ``risk'' (known chance and decisions under ``uncertainty'' (unmeasurable probability in his 1921 book Risk, Uncertainty and Profit. A closer reading of Knight (1921 reveals a host of psychological insights beyond this risk-uncertainty distinction, many of which foreshadow revolutionary advances in psychological decision theory from the latter half of the 20th century. Knight's description of economic decision making shared much with Simon's (1955, 1956 notion of bounded rationality, whereby choice behavior is regulated by cognitive and environmental constraints. Knight described features of risky choice that were to become key components of prospect theory (Kahneman and Tversky, 1979: the reference dependent valuation of outcomes, and the non-linear weighting of probabilities. Knight also discussed several biases in human decision making, and pointed to two systems of reasoning: one quick, intuitive but error prone, and a slower, more deliberate, rule-based system. A discussion of Knight's potential contribution to psychological decision theory emphasises the importance of a historical perspective on theory development, and the potential value of sourcing ideas from other disciplines or from earlier periods of time.

On Teaching International Courses on Health Information Systems Lessons Learned during 16 Years of Frank - van Swieten Lectures on Strategic Information Management in Health Information Systems

NARCIS (Netherlands)

Ammenwerth, Elske; Knaup, Petra; Winter, Alfred; Bauer, Axel W.; Bott, Oliver J.; Gietzelt, Matthias; Haarbrandt, Birger; Hackl, Werner O.; Hellrung, Nils; Huebner-Bloder, Gudrun; Jahn, Franziska; Jaspers, Monique W.; Kutscha, Ulrike; Machan, Christoph; Oppermann, Bianca; Pilz, Jochen; Schwartze, Jonas; Seidel, Christoph; Slot, Jan-Eric; Smers, Stefan; Spitalewsky, Katharina; Steckel, Nathalie; Struebing, Alexander; van der Haak, Minne; Haux, Reinhold; ter Burg, Willem J.

2017-01-01

Background: Health information systems (HIS) are one of the most important areas for biomedical and health informatics. In order to professionally deal with HIS well-educated informaticians are needed. Because of these reasons, in 2001 an international course has been established: The Frank - van

Design, Synthesis and Fungicidal Activities of Some Novel Pyrazole Derivatives

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Xue-Ru Liu

2014-09-01

Full Text Available In order to discover new compounds with good fungicidal activities, 32 pyrazole derivatives were designed and synthesized. The structures of the target compounds were confirmed by 1H-NMR, 13C-NMR, and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS, and their fungicidal activities against Botrytis cinerea, Rhizoctonia solani Kuhn, Valsa mali Miyabe et Yamada, Thanatephorus cucumeris (Frank Donk, Fusarium oxysporum (S-chl f.sp. cucumerinum Owen, and Fusarium graminearum Schw were tested. The bioassay results indicated that most of the derivatives exhibited considerable antifungal activities, especially compound 26 containing a p-trifluoromethyl- phenyl moiety showed the highest activity, with EC50 values of 2.432, 2.182, 1.787, 1.638, 6.986, and 6.043 μg/mL against B. cinerea, R. solani, V. mali, T. cucumeris, F. oxysporum, and F. graminearum, respectively. Moreover, the activities of compounds such as compounds 27–32 were enhanced by introducing isothiocyanate and carboxamide moieties to the 5-position of the pyrazole ring.

Factores determinantes de la deserción escolar en el Policlínico Docente "Frank País García" Determinant factors of the school desertion in «Frank País García» Teaching Polyclinic from Santiago de Cuba

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Nadia Inés Infante Tavío

2012-04-01

Full Text Available Se realizó un estudio de tipo investigación en el campo de la educación médica de pregrado a 33 estudiantes del primer año de medicina en el primer semestre del curso 2010-2011 en el Policlínico Docente "Frank País García" de Santiago de Cuba, con vistas a identificar los factores determinantes de la deserción escolar de este período. Para obtener la información, se aplicó un cuestionario a los educandos, avalado por criterios de expertos, y se llevaron a cabo métodos teóricos y empíricos (descritos en el trabajo. Se obtuvo que la deserción escolar fuera elevada y entre sus principales causas estuvieron la insuficiencia docente, el abandono y la falta de orientación vocacional.A study of investigation type was carried out in the field of pregraduate medical education to 33 first year students in the first semester of the course 2010-2011 at "Frank País García" Polyclinic in Santiago de Cuba, with the objective of identifying the determinant factors of the school desertion in this period. To obtain the information, a inquiry was applied to the students, endorsed by experts' criteria, and theoretical and empiric methods (described in the work were carried out. It was obtained that the school desertion was high and among its main causes there were teaching inadequacy, desertion and the lack of vocational guide.

Comparison of two views of maximum entropy in biodiversity: Frank (2011) and Pueyo et al. (2007).

Science.gov (United States)

Pueyo, Salvador

2012-05-01

An increasing number of authors agree in that the maximum entropy principle (MaxEnt) is essential for the understanding of macroecological patterns. However, there are subtle but crucial differences among the approaches by several of these authors. This poses a major obstacle for anyone interested in applying the methodology of MaxEnt in this context. In a recent publication, Frank (2011) gives some arguments why his own approach would represent an improvement as compared to the earlier paper by Pueyo et al. (2007) and also to the views by Edwin T. Jaynes, who first formulated MaxEnt in the context of statistical physics. Here I show that his criticisms are flawed and that there are fundamental reasons to prefer the original approach.

The role of the Frank-Starling law in the transduction of cellular work to whole organ pump function: a computational modeling analysis.

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Steven A Niederer

2009-04-01

Full Text Available We have developed a multi-scale biophysical electromechanics model of the rat left ventricle at room temperature. This model has been applied to investigate the relative roles of cellular scale length dependent regulators of tension generation on the transduction of work from the cell to whole organ pump function. Specifically, the role of the length dependent Ca(2+ sensitivity of tension (Ca(50, filament overlap tension dependence, velocity dependence of tension, and tension dependent binding of Ca(2+ to Troponin C on metrics of efficient transduction of work and stress and strain homogeneity were predicted by performing simulations in the absence of each of these feedback mechanisms. The length dependent Ca(50 and the filament overlap, which make up the Frank-Starling Law, were found to be the two dominant regulators of the efficient transduction of work. Analyzing the fiber velocity field in the absence of the Frank-Starling mechanisms showed that the decreased efficiency in the transduction of work in the absence of filament overlap effects was caused by increased post systolic shortening, whereas the decreased efficiency in the absence of length dependent Ca(50 was caused by an inversion in the regional distribution of strain.

Analysis of the bioclimatic strategies used by Frank Lloyd Wright in the Jacobs I house

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M. Beltrán-Fernández

2017-10-01

Full Text Available Frank Lloyd Wright is considered one of the most influential architects of modern architecture due to the spatial and aesthetic qualities of his work. However, the importance of Wright’s construction and environmental solutions has been usually overlooked. In order to evaluate these qualities, the first house that Wright designed for the Jacobs family (Wisconsin, USA, 1937 has been analyzed. This well-known building has been much studied, and its architectural value much celebrated, but without analysing the advantages of the bioclimatic principles over interior environment. But how can the influence of this bioclimatic architecture be measured in terms of thermal comfort? Does the selected orientation improve interior comfort? And what about the natural ventilation or the deep overhangs? In order to assess this, a digital model for energy simulation has been built using Revit and Design Builder.

Photography in the boundaries of the visible. From Santiago Ramón y Cajal to Cecil Frank Powell

Directory of Open Access Journals (Sweden)

Francisco López-Cantos

2016-12-01

Full Text Available In this article, we analyze the use of photographic technologies of two renowned researchers whose investigation results would have been impossible to carry out, as occurs in Galileo a few centuries before with the use of imaging techniques, without the use of photography: Santiago Ramón y Cajal and Cecil Frank Powell, Nobel Prize winners in medicine in 1906 and in physics in 1950, respectively. These researchers were selected, first, because of their close relation with photography and, second, to clearly illustrate the gradual transgression of scientific photographic representation starting in the late nineteenth century from the visible to the invisible.

[Prenatal lead exposure related to cord blood brain derived neurotrophic factor (BDNF) levels and impaired neonatal neurobehavioral development].

Science.gov (United States)

Ren, L H; Mu, X Y; Chen, H Y; Yang, H L; Qi, W

2016-06-01

To explore the relationship between umbilical cord blood brain-derived neurotrophic factor (BDNF) and neonatal neurobehavioral development in lead exposure infants. All infants and their mother were randomly selected during 2011 to 2012, subjects were selected according to the umbilical cord blood lead concentrations, which contcentration of lead was higher than 0.48 μmol/L were taken into high lead exposure group, about 60 subjects included. Comparing to the high lead exposure group, according to gender, weight, pregnant week, length and head circumferenece, the level of cord blood lead concentration under 0.48 μmol/L were taken into control group, 60 cases included. Lead content was determined by graphite furnace atomic absorption spectrometry. Neonatal behavioral neurological assessment (NBNA) was used to determine the development of neonatal neuronal behavior. The content of BDNF was detected by ELISA. Comparing the BDNF and the NBNA score between two groups, and linear correlation was given on analysis the correlation between lead concentration in cord blood and BDNF, BDNF and the NBNA score. Lead content in high exposure group was (0.613±0.139) μmol/L, and higher than (0.336±0.142) μmol/L in low exposure group (t=3.21, PBDNF content in high exposure group which was (3.538±1.203) ng/ml was higher than low exposure group (2.464±0.918) ng/ml (t=7.60, PBDNF content was negatively correlated with NBNA summary score, passive muscle tension and active muscle tone score (r was -0.27, -0.29, -0.30, respectively, P values were BDNF was negatively correlated with neonatal neurodevelopment, may serve as a useful biomarker.

New Times, New Heroes : Ambiguity, Socio-Political Issues and Post Modernism in Frank Miller's Graphic Novel The Dark Knight Returns

OpenAIRE

Axelsson, Jan

2013-01-01

Frank Miller’s The Dark Knight Returns is one of the first graphic novels to redraw the map for this kind of literature but perhaps first and foremost for the characteristics of superheroes and villains. It is a story which we have read before in the sense that Batman, the eternal crime fighter, chases his arch enemies Two Face and the Joker, but it is also a new story in which we meet an ambiguous and complex superhero. Batman has become an old man tormented by his past, in which his side ki...

Intensive mutagenesis of the nisin hinge leads to the rational design of enhanced derivatives.

Directory of Open Access Journals (Sweden)

Brian Healy

Full Text Available Nisin A is the most extensively studied lantibiotic and has been used as a preservative by the food industry since 1953. This 34 amino acid peptide contains three dehydrated amino acids and five thioether rings. These rings, resulting from one lanthionine and four methyllanthionine bridges, confer the peptide with its unique structure. Nisin A has two mechanisms of action, with the N-terminal domain of the peptide inhibiting cell wall synthesis through lipid II binding and the C-terminal domain responsible for pore-formation. The focus of this study is the three amino acid 'hinge' region (N 20, M 21 and K 22 which separates these two domains and allows for conformational flexibility. As all lantibiotics are gene encoded, novel variants can be generated through manipulation of the corresponding gene. A number of derivatives in which the hinge region was altered have previously been shown to possess enhanced antimicrobial activity. Here we take this approach further by employing simultaneous, indiscriminate site-saturation mutagenesis of all three hinge residues to create a novel bank of nisin derivative producers. Screening of this bank revealed that producers of peptides with hinge regions consisting of AAK, NAI and SLS displayed enhanced bioactivity against a variety of targets. These and other results suggested a preference for small, chiral amino acids within the hinge region, leading to the design and creation of producers of peptides with hinges consisting of AAA and SAA. These producers, and the corresponding peptides, exhibited enhanced bioactivity against Lactococcus lactis HP, Streptococcus agalactiae ATCC 13813, Mycobacterium smegmatis MC2155 and Staphylococcus aureus RF122 and thus represent the first example of nisin derivatives that possess enhanced activity as a consequence of rational design.

The critical role of cognitive-based trait differences in transcranial direct current stimulation (tDCS) suppression of food craving and eating in frank obesity.

Science.gov (United States)

Ray, Mary Katherine; Sylvester, Maria D; Osborn, Lauren; Helms, Joel; Turan, Bulent; Burgess, Emilee E; Boggiano, Mary M

2017-09-01

Obesity remains a major public health concern and novel treatments are needed. Transcranial direct current stimulation (tDCS) is a neuromodulation technique shown to reduce food craving and consumption, especially when targeting the dorsolateral prefrontal cortex (DLPFC) with a right anode/left cathode electrode montage. Despite the implications to treat frank (non-bingeeating) obesity, no study has tested the right anode/left cathode montage in this population. Additionally, most tDCS appetite studies have not controlled for differences in traits under DLPFC control that may influence how well one responds to tDCS. Hence, N = 18 (10F/8M) adults with frank obesity completed the Dutch Eating Behavior Questionnaire-Restraint and Barratt Impulsiveness Scale, and received 20 min of 2 mA active tDCS and control tDCS session. Craving and eating was assessed at both sessions with a food photo "wanting" test and in-lab measures of total, preferred, and less-preferred kilocalories consumed of three highly palatable snack foods. While main effects of tDCS vs. control were not found, significant differences emerged when trait scores were controlled. tDCS reduced food craving in females with lower attention-type impulsiveness (p = 0.047), reduced preferred-food consumption in males with lower intent to restrict calories (p = 0.024), and reduced total food consumption in males with higher non-planning-type impulsiveness (p = 0.009) compared to control tDCS. This is the first study to find significant reductions in food craving and consumption in a sample with frank obesity using the most popular tDCS montage in appetite studies. The results also highlight the cognitive-based heterogeneity of individuals with obesity and the importance of considering these differences when evaluating the efficacy of DLPFC-targeted tDCS in future studies aimed at treating obesity. Copyright © 2017 Elsevier Ltd. All rights reserved.

Frank McCourt’s Teacher Man: A Novel Approach to Teacher Learning and Professional Development

Directory of Open Access Journals (Sweden)

Renate Schulz

2009-07-01

Full Text Available The purpose of this research was to investigate how stories can be a learning tool to help teachers make sense of and learn from their own stories of teaching. The participants in this study were teachers enrolled in a graduate level course.  Frank McCourt’s novel, Teacher Man acted as a stimulus, springboard and guide for class discussions and for teachers writing their own story of teaching. My mode of inquiry included collecting the teachers’ written responses to class readings, noting their oral responses during class discussions, asking them to complete a short questionnaire, and following up with a taped focus group three months after the completion of the course. By reading, hearing and discussing the stories of others, teachers came to recognize the power of stories.  Writing their own stories helped them to understand their own practice better.

Lead sorption characteristics of various chicken bone part-derived chars.

Science.gov (United States)

Park, Jong-Hwan; Wang, Jim J; Kim, Seong-Heon; Kang, Se-Won; Cho, Ju-Sik; Delaune, Ronald D; Ok, Yong Sik; Seo, Dong-Cheol

2018-01-18

Recycling food waste for beneficial use is becoming increasingly important in resource-limited economy. In this study, waste chicken bones of different parts from restaurant industry were pyrolyzed at 600 °C and evaluated for char physicochemical properties and Pb sorption characteristics. Lead adsorption isotherms by different chicken bone chars were carried out with initial Pb concentration range of 1-1000 mg L -1 at pH 5. The Pb adsorption data were better described by the Langmuir model (R 2  = 0.9289-0.9937; ARE = 22.7-29.3%) than the Freundlich model (R 2  = 0.8684-0.9544; ARE = 35.4-72.0%). Among the chars derived from different chicken bone parts, the tibia bone char exhibited the highest maximum Pb adsorption capacity of 263 mg g -1 followed by the pelvis (222 mg g -1 ), ribs (208 mg g -1 ), clavicle (179 mg g -1 ), vertebrae (159 mg g -1 ), and humerus (135 mg g -1 ). The Pb adsorption capacities were significantly and positively correlated with the surface area, phosphate release amount, and total phosphorus content of chicken bone chars (r ≥ 0.9711). On the other hand, approximately 75-88% of the adsorbed Pb on the chicken bone chars was desorbable with 0.1 M HCl, indicating their recyclability for reuse. Results demonstrated that chicken bone char could be used as an effective adsorbent for Pb removal in wastewater.

Optical Studies on Sol-Gel Derived Lead Chloride Crystals

OpenAIRE

Rejeena, I; Lillibai, B; Nithyaja, B; Nampoori, P.N V; Radhakrishnan, P

2013-01-01

Optical characterization of lead chloride crystals prepared by sol-gel method is reported. The relevant sol-gel technique is used for the preparation of PbCl2 samples with five different types. In this paper, we report the absorption and fluorescence behaviour of pure, UV& IR irradiated and electric & magnetic field applied lead chloride crystal samples in solution phase at two different concentrations. Optical bandgap and emission studies of these crystals are also done.

(C6H13N)2BiI5: A One-Dimensional Lead-Free Perovskite-Derivative Photoconductive Light Absorber.

Science.gov (United States)

Zhang, Weichuan; Tao, Kewen; Ji, Chengmin; Sun, Zhihua; Han, Shiguo; Zhang, Jing; Wu, Zhenyue; Luo, Junhua

2018-04-16

Lead-free organic-inorganic hybrid perovskites have recently attracted intense interest as environmentally friendly, low-cost, chemically stable light absorbers. Here, we reported a new one-dimensional (1D) zigzag chainlike light-absorbing hybrid material of (C 6 H 13 N) 2 BiI 5 , in which the corner-sharing octahedral bismuth halide chains are surrounded by organic cations of tetramethylpiperidinium. This unique zigzag 1D hybrid perovskite-derivative material shows a narrow direct band gap of 2.02 eV and long-lived photoluminescence, which is encouraging for optoelectronic applications. Importantly, it behaves as a typical semiconducting material and displays obvious photoresponse in the visible-light range. This work opens a potential pathway for the further application of 1D lead-free hybrids.

Derivative spectrophotometric determination of trace lead in alloys ...

African Journals Online (AJOL)

diethylaminophenol-ammonium tetraphenylborate with microcrystalline naphthalene or by a column method in the pH range 4.0–6.0 from a large volume of aqueous solutions of various samples. After filtration, the solid mass consisting of the lead complex and ...

“The root of all evil”: Frank McGuinness’ Translations of Greek Drama

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Loredana Salis

2014-07-01

Full Text Available Whether in political propaganda or in creative the myths of ancient Greece have long attracted scholars, writers and audiences from Ireland. Over the past forty years, a wealth of adaptations of plays by Sophocles and Euripides have been produced, which bring back to life ancient tales of heroes and heroines, in settings at times distinctively local and contemporary, at times deliberately universal. Field Day’s contributions represent a typical instance of the former approach to the classics, while other Irish playwrights have used Greek myths to reflect upon questions that are not exclusively Irish. Their plays may have an Irish echo, and some are even set in Ireland, but their main preoccupation lies beyond geographical borders. Frank McGuinness belongs to this second group of playwrights. To date, he has reworked and staged five Greek plays with great audience and critical acclaim. This paper locates his translations of Sophocles and Euripides within the tradition of classical tragedy use in Ireland at the crossroads between the local and the global and at the search of what he calls ‘the root of all evil’ with special attention to his Oedipus (2008 and Helen (2009.

The cross-bridge dynamics is determined by two length-independent kinetics: Implications on muscle economy and Frank-Starling Law.

Science.gov (United States)

Amiad Pavlov, Daria; Landesberg, Amir

2016-01-01

The cellular mechanisms underlying the Frank-Starling Law of the heart and the skeletal muscle force-length relationship are not clear. This study tested the effects of sarcomere length (SL) on the average force per cross-bridge and on the rate of cross-bridge cycling in intact rat cardiac trabeculae (n=9). SL was measured by laser diffraction and controlled with a fast servomotor to produce varying initial SLs. Tetanic contractions were induced by addition of cyclopiazonic acid, to maintain a constant activation. Stress decline and redevelopment in response to identical ramp shortenings, starting at various initial SLs, was analyzed. Both stress decline and redevelopment responses revealed two distinct kinetics: a fast and a slower phase. The duration of the rapid phases (4.2 ± 0.1 msec) was SL-independent. The second slower phase depicted a linear dependence of the rate of stress change on the instantaneous stress level. Identical slopes (70.5 ± 1.6 [1/s], p=0.33) were obtained during ramp shortening at all initial SLs, indicating that the force per cross-bridge and cross-bridge cycling kinetics are length-independent. A decrease in the slope at longer SLs was obtained during stress redevelopment, due to internal shortening. The first phase is attributed to rapid changes in the average force per cross-bridge. The second phase is ascribed to both cross-bridge cycling between its strong and weak conformations and to changes in the number of strong cross-bridges. Cross-bridge cycling kinetics and muscle economy are length-independent and the Frank-Starling Law cannot be attributed to changes in the force per cross-bridge or in the single cross-bridge cycling rates. Copyright © 2015 Elsevier Ltd. All rights reserved.

Anti-cancer Lead Molecule

KAUST Repository

Sagar, Sunil; Kaur, Mandeep; Esau, Luke E.

2014-01-01

Derivatives of plumbagin can be selectively cytotoxic to breast cancer cells. Derivative `A` (Acetyl Plumbagin) has emerged as a lead molecule for testing against estrogen positive breast cancer and has shown low hepatotoxicity as well as overall lower toxicity in nude mice model. The toxicity of derivative `A` was determined to be even lower than vehicle control (ALT and AST markers). The possible mechanism of action identified based on the microarray experiments and pathway mapping shows that derivative `A` could be acting by altering the cholesterol-related mechanisms. The low toxicity profile of derivative `A` highlights its possible role as future anti-cancer drug and/or as an adjuvant drug to reduce the toxicity of highly toxic chemotherapeutic drugs

Anti-cancer Lead Molecule

KAUST Repository

Sagar, Sunil

2014-04-17

Derivatives of plumbagin can be selectively cytotoxic to breast cancer cells. Derivative `A` (Acetyl Plumbagin) has emerged as a lead molecule for testing against estrogen positive breast cancer and has shown low hepatotoxicity as well as overall lower toxicity in nude mice model. The toxicity of derivative `A` was determined to be even lower than vehicle control (ALT and AST markers). The possible mechanism of action identified based on the microarray experiments and pathway mapping shows that derivative `A` could be acting by altering the cholesterol-related mechanisms. The low toxicity profile of derivative `A` highlights its possible role as future anti-cancer drug and/or as an adjuvant drug to reduce the toxicity of highly toxic chemotherapeutic drugs

Lead isotopes as seepage indicators around a uranium tailings dam

International Nuclear Information System (INIS)

Gulson, B.L.; Mizon, K.J.; Korsch, M.J.; Noller, B.N.

1989-01-01

Lead isotope ratios and lead concentrations have been measured in water from 26 bores around the Ranger uranium tailings dam, Northern Territory, Australia, and from the dam itself to determine possible migration of lead derived from the radioactive decay of uranium. Lead isotope compositions have also been measured for the particulates retained on selected filters. The concentration of lead in the bore waters is extremely low (usually 206 Pb/ 204 Pb ratio measured in the bore waters differs by more than a factor of 100 from that in the tailings dam and shows no evidence of lead derived from a significant uranium accumulation. It may be possible to distinguish between lead from the tailings dam and that derived from a nearby uranium ore body

The 'pay ratio' provision of the Dodd-Frank Act 2010 and presentation of the Paulo–Le Roux Index

Directory of Open Access Journals (Sweden)

Stanley Paulo

2016-08-01

Full Text Available Orientation: This article addresses the issues of executive remuneration and whether it was excessive or not. Research purpose: On 05 August 2015, the US Securities and Exchange Commission (SEC adopted a rule to operationalise Section 953(b of the Dodd-Frank Wall Street Reform and Consumer Protection Act 2010 (Dodd-Frank or the Dodd-Frank Act 2010, the ‘pay ratio provision’, as part of a process to ensure sound corporate governance and shed light on assertions that corporate executive remuneration was excessive and detrimental to the economic wellbeing of the USA. This pay ratio rule will be operative starting from 2017 and requires public firms to publish the ratio of chief executive officer (CEO remuneration to the median remuneration of all its employees. Hence, it is a measure of income distribution. It does not reveal the relationship between executive compensation and the value added to the firm by executives. In anticipation of this rule becoming mandatory and as part of a quest to quantify the value of executives to the firm, Paulo and Le Roux (2014 developed an approach to measure the value executives add to the firm, drawing from audited financial statements and thereby demonstrating that the value added by executive management could be measured according to the requirements of sound research methodology and rigorous epistemology. Motivation for the study: Statutory enactment of the pay ratio provision provided the impetus to create an index, the Paulo–Le Roux Index, that shows how much executives are paid in relation to how much value they add to the firm. Research design, approach and method: Paulo and Le Roux (2014 developed an approach to measure the value executives add to the firm, drawing from audited financial statements and thereby demonstrating that the value added by executive management could be measured according to the requirements of sound research methodology and rigorous epistemology. Statutory enactment of the

CAD/CAM, Creativity, and Discipline Lead to Turnaround School Success

Science.gov (United States)

Gorman, Lynn

2012-01-01

Miami Central High School technology teacher Frank Houghtaling thinks the connection between theory and application is one reason his students perform better on the Florida Comprehensive Assessment Test (FCAT). The impressive turnaround school drew local and national attention last spring when one of Houghtaling's students, Dagoberto Cruz, won…

Frank Gilbreth and health care delivery method study driven learning.

Science.gov (United States)

Towill, Denis R

2009-01-01

The purpose of this article is to look at method study, as devised by the Gilbreths at the beginning of the twentieth century, which found early application in hospital quality assurance and surgical "best practice". It has since become a core activity in all modern methods, as applied to healthcare delivery improvement programmes. The article traces the origin of what is now currently and variously called "business process re-engineering", "business process improvement" and "lean healthcare" etc., by different management gurus back to the century-old pioneering work of Frank Gilbreth. The outcome is a consistent framework involving "width", "length" and "depth" dimensions within which healthcare delivery systems can be analysed, designed and successfully implemented to achieve better and more consistent performance. Healthcare method (saving time plus saving motion) study is best practised as co-joint action learning activity "owned" by all "players" involved in the re-engineering process. However, although process mapping is a key step forward, in itself it is no guarantee of effective re-engineering. It is not even the beginning of the end of the change challenge, although it should be the end of the beginning. What is needed is innovative exploitation of method study within a healthcare organisational learning culture accelerated via the Gilbreth Knowledge Flywheel. It is shown that effective healthcare delivery pipeline improvement is anchored into a team approach involving all "players" in the system especially physicians. A comprehensive process study, constructive dialogue, proper and highly professional re-engineering plus managed implementation are essential components. Experience suggests "learning" is thereby achieved via "natural groups" actively involved in healthcare processes. The article provides a proven method for exploiting Gilbreths' outputs and their many successors in enabling more productive evidence-based healthcare delivery as summarised

The large magnetoelectric effect in Ni-lead zirconium titanate-Ni trilayers derived by electroless deposition

International Nuclear Information System (INIS)

Bi, K; Wang, Y G; Wu, W; Pan, D A

2010-01-01

Magnetoelectric (ME) Ni-lead zirconium titanate-Ni trilayers with neither electrodes nor bonding layers have been derived by electroless deposition. The structure and magnetic properties of the electroless deposited Ni layers with different pH values are characterized by x-ray diffraction and vibrating sample magnetometer. The influence of the bias magnetic field and the magnetic field frequency (f) on ME coupling is discussed. It is seen that α E,31 depends strongly on H dc and f. The value of the ME coefficient increases as the thickness of the Ni layer and the pH of the bath increase. A maximum of the ME voltage coefficient α E,31 = 5.77 V cm -1 Oe -1 at resonance frequency with a deposited Ni layer thickness t Ni = 302 μm is obtained. The large ME coefficient makes these Ni-PZT-Ni trilayers suitable for applications in sensors, actuators and transducers. (fast track communication)

Electronic publication of new animal names - An interview with Frank-T. Krell, Commissioner of the International Commission on Zoological Nomenclature and Chair of the ICZN ZooBank Committee

Science.gov (United States)

2012-01-01

On the 4th September 2012 the International Commission on Zoological Nomenclature announced an amendment to the International Code of Zoological Nomenclature allowing for electronic publication of the scientific names of animals. In this interview Frank-T. Krell discusses the implications of this amendment for authors wishing to publish descriptions of newly identified animal species in online and open access journals, and for the future of taxonomic science. PMID:22978411

Higher derivative regularization and chiral anomaly

International Nuclear Information System (INIS)

Nagahama, Yoshinori.

1985-02-01

A higher derivative regularization which automatically leads to the consistent chiral anomaly is analyzed in detail. It explicitly breaks all the local gauge symmetry but preserves global chiral symmetry and leads to the chirally symmetric consistent anomaly. This regularization thus clarifies the physics content contained in the consistent anomaly. We also briefly comment on the application of this higher derivative regularization to massless QED. (author)

Frank Robert Tangherlini — the Founder of an Alternative Relativistic Kinematics (On the Occasion of His 85th Birthday

Directory of Open Access Journals (Sweden)

Malykin G. B.

2009-01-01

Full Text Available Already fifty years ago, Frank Robert Tangherlini, an American theoretical physicist, suggested an original procedure which, targeting the synchronization of clocks located in two different inertial reference frames of the space, was di erent from that Einstein had introduced. As a result of these, Tangherlini had deduced the so-called the Tangher- lini transformations, which are a sort of the transformations of the spatial coordinates and time being moved from one inertial reference frame into another one. The Tangher- lini transformations differ from the Lorentz transformations (which can be meant clas- sic ones in the theory of relativity and, in particular, suggest the velocity of light to be anisotropic in a moving inertial reference frame. The Tangherlini transformations be- ing applied provide adequate explanations to all well-known interference experiments checking of the Special Theory of Relativity.

War, Medicine, and Cultural Diplomacy in the Americas: Frank Wilson and Brazilian cardiology.

Science.gov (United States)

Kropf, Simone P; Howell, Joel D

2017-10-01

American cultural diplomacy played a key role in the institutionalization of Brazilian cardiology. In 1942, Frank Wilson, an internationally recognized pioneer in electrocardiography, made an extended wartime visit to Rio de Janeiro and São Paulo. The visit was sponsored by the United States Department of State as part of Roosevelt's Good Neighbor Policy and brought Wilson together with a group of physicians who would establish the specialty of cardiology in Brazil. This US cultural and diplomatic initiative strengthened an academic network that was already evolving and would eventually prove to be of benefit to both sides. Latin American physicians began in the 1920s to visit Wilson's laboratory at the University of Michigan, where they established the relationships on which Wilson would build. While affiliation with the "Wilson school" advanced the cause of Brazilian cardiologists who sought to establish themselves as specialists, cooperation with Latin American physicians benefitted Wilson in his pursuit of wider recognition for his innovations in the use of electrocardiography (ECG). Wilson's identity as a scientific ambassador to Latin America helped in legitimating his approach to the clinical application of the ECG. A close examination of Wilson's relationship to Brazilian cardiology demonstrates the role played by science and medicine as a part of wartime cultural diplomacy, as well as the dynamics of the transnational circulation of scientific knowledge and practices. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Diffusivity, activity and solubility of oxygen in liquid lead and lead-bismuth eutectic alloy by electrochemical methods

International Nuclear Information System (INIS)

Ganesan, Rajesh; Gnanasekaran, T.; Srinivasa, Raman S.

2006-01-01

The diffusivity of oxygen in liquid lead and lead-bismuth eutectic (LBE) alloy was measured by a potentiostatic method and is given by log(D O Pb /cm 2 s -1 )=-2.554-2384/T(+/-0.070), 818-1061K, and log(D O LBE /cm 2 s -1 )=-0.813-3612/T(+/-0.091), 811-980K. The activity of oxygen in lead and LBE was determined by coulometric titration experiments. Using the measured data, the standard free energy of dissolution of oxygen in liquid lead and LBE was derived and is given byG O(Pb) xs =-121349+16.906T(+/-560)J(gatomO) -1 ,815-1090K,G O(LBE) xs = -127398+27.938T(+/-717)J(gatomO) -1 ,812-1012K.Using the above data, the Gibbs energy of formation of PbO(s) and equilibrium oxygen pressures measured over the oxygen-saturated LBE alloy, the solubility of oxygen in liquid lead and LBE were derived. The solubility of oxygen in liquid lead and LBE are given by log(S/at.%O)=-5100/T+4.32 (+/-0.04), 815-1090K and log(S/at.%O)=-4287/T+3.53 (+/-0.06), 812-1012K respectively.

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation

NARCIS (Netherlands)

Leuner, K.; Schutt, T.; Kurz, C.; Eckert, S.H.; Schiller, C.; Occhipinti, A.; Mai, S.; Jendrach, M.; Eckert, G.P.; Kruse, S.E.; Palmiter, R.D.; Brandt, U.; Drose, S.; Wittig, I.; Willem, M.; Haass, C.; Reichert, A.S.; Muller, W.E.

2012-01-01

AIMS: Intracellular amyloid beta (Abeta) oligomers and extracellular Abeta plaques are key players in the progression of sporadic Alzheimer's disease (AD). Still, the molecular signals triggering Abeta production are largely unclear. We asked whether mitochondrion-derived reactive oxygen species

Structure activity relationships of quinoxalin-2-one derivatives as platelet-derived growth factor-beta receptor (PDGFbeta R) inhibitors, derived from molecular modeling.

Science.gov (United States)

Mori, Yoshikazu; Hirokawa, Takatsugu; Aoki, Katsuyuki; Satomi, Hisanori; Takeda, Shuichi; Aburada, Masaki; Miyamoto, Ken-ichi

2008-05-01

We previously reported a quinoxalin-2-one compound (Compound 1) that had inhibitory activity equivalent to existing platelet-derived growth factor-beta receptor (PDGFbeta R) inhibitors. Lead optimization of Compound 1 to increase its activity and selectivity, using structural information regarding PDGFbeta R-ligand interactions, is urgently needed. Here we present models of the PDGFbeta R kinase domain complexed with quinoxalin-2-one derivatives. The models were constructed using comparative modeling, molecular dynamics (MD) and ligand docking. In particular, conformations derived from MD, and ligand binding site information presented by alpha-spheres in the pre-docking processing, allowed us to identify optimal protein structures for docking of target ligands. By carrying out molecular modeling and MD of PDGFbeta R in its inactive state, we obtained two structural models having good Compound 1 binding potentials. In order to distinguish the optimal candidate, we evaluated the structural activity relationships (SAR) between the ligand-binding free energies and inhibitory activity values (IC50 values) for available quinoxalin-2-one derivatives. Consequently, a final model with a high SAR was identified. This model included a molecular interaction between the hydrophobic pocket behind the ATP binding site and the substitution region of the quinoxalin-2-one derivatives. These findings should prove useful in lead optimization of quinoxalin-2-one derivatives as PDGFb R inhibitors.

Lead isotopes in mantle derived xenoliths from Japan and South Africa

International Nuclear Information System (INIS)

Morioka, Masana; Kigoshi, Kunihiko.

1978-01-01

The lead isotopic compositions and the uranium, thorium and lead contents of eclogite and harzburgite inclusions from South African Kimberlite-pipes and lherzolite inclusions from Itinomegata crater, Japan and of their main mineral fractions have been determined. The observed 206 Pb/ 204 Pb, 207 Pb/ 204 Pb and 238 U/ 204 Pb in lherzolite samples from Itinomegata range from 17.9 to 18.2, from 15.1 to 15.5 and from 1.9 to 23, respectively. The results suggest that the lherzolites were of recent crystallization. The observed data on eclogite inclusions show no consistent pattern and suggest that they have a complicated history. The observed lead isotopic compositions of harzburgite inclusions from kimberlite-pipes are 206 Pb/ 204 Pb = 17.3 -- 19.0 and 207 Pb/ 204 Pb = 15.3 -- 15.6. These results are distributed in a wide range on two regression lines, suggesting that they had been formed from the same source material but with different ages or have been formed recently by mixing of two different source materials and host rock of kimberlite. (author)

Victorian Imag(ining of the Pagan Pyre: Frank Dicksee's 'Funeral of a Viking'

Directory of Open Access Journals (Sweden)

Nancy Rose Marshall

2017-12-01

Full Text Available Victorians drew on imagery of Druid and Viking funeral pyres as a way of exploring alternative narratives of death and burial, generating a collective attention to what happened to a body after death. I set Frank Dicksee’s oil painting, 'Funeral of a Viking' (1893, against the background of the emergent cremation movement and accounts of the neo-Druid William Price, a proponent for the legalization of cremation in the 1880s, in order to glimpse the work performed by the visualization of the ritualized burning of human beings in the pagan past. Fire produces metamorphosis in the objects it encounters, and Dicksee’s portrayal underscores the notion of a clearly delineated human body transforming into amorphous flame. Moreover, the Viking dissolves into pigment itself, mere aesthetic effect taking the place of a recognizable figure. In fictional accounts such as Paul Du Chaillu’s novel 'Ivar the Viking '(1893, the pyre as a narrative tool similarly forced attention to the body as dematerializing thing and to the language articulating this dissipation. I suggest that the Victorian fascination with pagan fire-death allowed for alternate visions of form–matter relationships that in turn might produce new aesthetic possibilities. As the Christian world insisted on the resurrection of the body in a way that clung fiercely to tangibility and bounded form even in the face of belief in the immortality of the saved soul, the modern moment might be seen, in contrast, as characterized by an embrace of an aesthetic of dissolving form or formlessness.

Multitarget Therapeutic Leads for Alzheimer's Disease: Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Dual Inhibitors of Cholinesterases and β-Amyloid (Aβ) Aggregation.

Science.gov (United States)

Tonelli, Michele; Catto, Marco; Tasso, Bruno; Novelli, Federica; Canu, Caterina; Iusco, Giovanna; Pisani, Leonardo; Stradis, Angelo De; Denora, Nunzio; Sparatore, Anna; Boido, Vito; Carotti, Angelo; Sparatore, Fabio

2015-06-01

Multitarget therapeutic leads for Alzheimer's disease were designed on the models of compounds capable of maintaining or restoring cell protein homeostasis and of inhibiting β-amyloid (Aβ) oligomerization. Thirty-seven thioxanthen-9-one, xanthen-9-one, naphto- and anthraquinone derivatives were tested for the direct inhibition of Aβ(1-40) aggregation and for the inhibition of electric eel acetylcholinesterase (eeAChE) and horse serum butyrylcholinesterase (hsBChE). These compounds are characterized by basic side chains, mainly quinolizidinylalkyl moieties, linked to various bi- and tri-cyclic (hetero)aromatic systems. With very few exceptions, these compounds displayed inhibitory activity on both AChE and BChE and on the spontaneous aggregation of β-amyloid. In most cases, IC50 values were in the low micromolar and sub-micromolar range, but some compounds even reached nanomolar potency. The time course of amyloid aggregation in the presence of the most active derivative (IC50 =0.84 μM) revealed that these compounds might act as destabilizers of mature fibrils rather than mere inhibitors of fibrillization. Many compounds inhibited one or both cholinesterases and Aβ aggregation with similar potency, a fundamental requisite for the possible development of therapeutics exhibiting a multitarget mechanism of action. The described compounds thus represent interesting leads for the development of multitarget AD therapeutics. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

An exploratory study of lead recovery in lead-acid battery lifecycle in US market: An evidence-based approach

International Nuclear Information System (INIS)

Genaidy, A.M.; Sequeira, R.; Tolaymat, T.; Kohler, J.; Rinder, M.

2008-01-01

Background: This research examines lead recovery and recycling in lead-acid batteries (LAB) which account for 88% of US lead consumption. We explore strategies to maximize lead recovery and recycling in the LAB lifecycle. Currently, there is limited information on recycling rates for LAB in the published literature and is derived from a single source. Therefore, its recycling efforts in the US has been unclear so as to determine the maximum opportunities for metal recovery and recycling in the face of significant demands for LAB particularly in the auto industry. Objectives: The research utilizes an evidence-based approach to: (1) determine recycling rates for lead recovery in the LAB product lifecycle for the US market; and (2) quantify and identify opportunities where lead recovery and recycling can be improved. Methods: A comprehensive electronic search of the published literature was conducted to gather information on different LAB recycling models and actual data used to calculate recycling rates based on product lifecycle for the US market to identify strategies for increasing lead recovery and recycling. Results: The electronic search yielded five models for calculating LAB recycling rates. The description of evidence was documented for each model. Furthermore, an integrated model was developed to identify and quantify the maximum opportunities for lead recovery and recycling. Results showed that recycling rates declined during the period spanning from 1999 to 2006. Opportunities were identified for recovery and recycling of lead in the LAB product lifecycle. Concluding remarks: One can deduce the following from the analyses undertaken in this report: (1) lead recovery and recycling has been stable between 1999 and 2006; (2) lead consumption has increased at an annual rate of 2.25%, thus, the values derived in this study for opportunities dealing with lead recovery and recycling underestimate the amount of lead in scrap and waste generated; and (3) the

4-Aminoquinoline derivatives

DEFF Research Database (Denmark)

Singh, Shailja; Agarwal, Drishti; Sharma, Kumkum

2016-01-01

and found them to be effective against Plasmodium falciparum under in vitro conditions. Further, we selected four most active derivatives 1m, 1o, 2c and 2j and evaluated their antimalarial potential against Plasmodium berghei in vivo. These 4-aminoquinolines cured BALB/c mice infected with P. berghei......Synthetic quinoline derivatives continue to be considered as candidates for new drug discovery if they act against CQ-resistant strains of malaria even after the widespread emergence of resistance to CQ. In this study, we explored the activities of two series of new 4-aminoquinoline derivatives...... for structure activity relationship to find lead molecules for treating multidrug-resistant Plasmodium falciparum and Plasmodium vivax....

The Anne Frank Haven: A case of an alternative educational program in an integrative Kibbutz setting

Science.gov (United States)

Ben-Peretz, Miriam; Giladi, Moshe; Dror, Yuval

1992-01-01

The essential features of the programme of the Anne Frank Haven are the complete integration of children from low SES and different cultural backgrounds with Kibbutz children; a holistic approach to education; and the involvement of the whole community in an "open" residential school. After 33 years, it is argued that the experiment has proved successful in absorbing city-born youth in the Kibbutz, enabling at-risk populations to reach significant academic achievements, and ensuring their continued participation in the dominant culture. The basic integration model consists of "layers" of concentric circles, in dynamic interaction. The innermost circle is the class, the learning community. The Kibbutz community and the foster parents form a supportive, enveloping circle, which enables students to become part of the outer community and to intervene in it. A kind of meta-environment, the inter-Kibbutz partnership and the Israeli educational system, influence the program through decision making and guidance. Some of the principles of the Haven — integration, community involvement, a year's induction for all new students, and open residential settings — could be useful for cultures and societies outside the Kibbutz. The real "secret" of success of an alternative educational program is the dedicated, motivated and highly trained staff.

Identification of two novel SH3PXD2B gene mutations in Frank-Ter Haar syndrome by exome sequencing: Case report and review of the literature.

Science.gov (United States)

Zrhidri, Abdelali; Jaouad, Imane Cherkaoui; Lyahyai, Jaber; Raymond, Laure; Egéa, Grégory; Taoudi, Mohamed; El Mouatassim, Said; Sefiani, Abdelaziz

2017-09-10

Frank-Ter Haar syndrome (FTHS) is an autosomal-recessive disorder characterized by skeletal, cardio-vascular, and eye abnormalities, such as increased intraocular pressure, prominent eyes, and hypertelorism. The most common underlying genetic defect in Frank-Ter Haar syndrome appears to be due to mutations in the SH3PXD2B gene on chromosome 5q35.1. Until now, only six mutations in SH3PXD2B gene have been identified. A genetic heterogeneity of FTHS was suggested in previous studies. FTHS was suspected clinically in a girl of 2years old, born from non-consanguineous Moroccan healthy parents. The patient had been referred to a medical genetics outpatient clinic for dysmorphic facial features. Whole Exome Sequencing (WES) was performed in the patient and her parents, in addition to Sanger sequencing that was carried out to confirm the results. We report the first description of a Moroccan FTHS patient with two novel compound heterozygous mutations c.806G>A; p.Trp269* (maternal allele) and c.892delC; p.Asp299Thrfs*44 (paternal allele) in the SH3PXD2B gene. Sanger sequencing confirmed this mutation in the affected girl and demonstrated that her parents carry this mutation in heterozygous state. Our results confirm the clinical diagnosis of FTHS in this reported family and contribute to expand the mutational spectrum of this rare disease. Our study shows also, that exome sequencing is a powerful and a cost-effective tool for the diagnosis of a supposed genetically heterogeneous disorder such FTHS. Copyright © 2017 Elsevier B.V. All rights reserved.

Synthesis of sulfadiazinyl acyl/aryl thiourea derivatives as calf intestinal alkaline phosphatase inhibitors, pharmacokinetic properties, lead optimization, Lineweaver-Burk plot evaluation and binding analysis.

Science.gov (United States)

Sajid-Ur-Rehman; Saeed, Aamer; Saddique, Gufran; Ali Channar, Pervaiz; Ali Larik, Fayaz; Abbas, Qamar; Hassan, Mubashir; Raza, Hussain; Fattah, Tanzeela Abdul; Seo, Sung-Yum

2018-06-02

To seek the new medicinal potential of sulfadiazine drug, the free amino group of sulfadiazine was exploited to obtain acyl/aryl thioureas using simple and straightforward protocol. Acyl/aryl thioureas are well recognized bioactive pharmacophore containing moieties. A new series (4a-4j) of sulfadiazine derived acyl/aryl thioureas was synthesized and characterized through spectroscopic and elemental analysis. The synthesized derivatives 4a-4j were subjected to calf intestinal alkaline phosphatase (CIAP) activity. The derivative 4a-4j showed better inhibition potential compared to standard monopotassium phosphate (MKP). The compound 4c exhibited higher potential in the series with IC 50 0.251 ± 0.012 µM (standard KH 2 PO 4 4.317 ± 0.201 µM). Lineweaver-Burk plots revealed that most potent derivative 4c inhibition CIAP via mixed type pathway. Pharmacological investigations showed that synthesized compounds 4a-4j obey Lipinsk's rule. ADMET parameters evaluation predicted that these molecule show significant lead like properties with minimum possible toxicity and can serve as templates in drug designing. The synthetic compounds show none mutagenic and irritant behavior. Molecular docking analysis showed that compound 4c interacts with Asp273, His317 and Arg166 amino acid residues. Copyright © 2018. Published by Elsevier Ltd.

Lead in Glasgow street dirt and soil

Energy Technology Data Exchange (ETDEWEB)

Farmer, J G [Univ. of Glasgow; Lyon, T D.B.

1977-07-01

The levels of lead in city street dirt and in soil from various locations in Glasgow were investigated during spring 1976. Lead concentrations in street dirt ranged from 150 to 2300 ppM, mean 960 ppM, and were significantly elevated with respect to the observed ''natural'' level of 78 ppM. Lead derived from anti-knock compounds in petrol and introduced to the environment via automobile exhausts was clearly implicated as the main source of lead pollution in a series of soil lead measurements at the centre and periphery of eight Glasgow parks. Various chemical leaching techniques were employed and compared. Less than 5 percent of street dirt and soil lead was found to be associated with the organic phase.

Case Report: Valproic Acid and Risperidone Treatment Leading to Development of Hyperammonemia and Mania

Science.gov (United States)

Carlson, Teri; Reynolds, Charles A.; Caplan, Rochelle

2007-01-01

This case report describes two children who developed hyperammonemia together with frank manic behavior during treatment with a combination of valproic acid and risperidone. One child had been maintained on valproic acid for years and risperidone was added. In the second case, valproic acid was introduced to a child who had been treated with…

Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives

Directory of Open Access Journals (Sweden)

Sarah Rioton

2017-03-01

Full Text Available A comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references. These compounds have been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives by introduction a trifluoromethyl group, from pyridine or pyridinone derivatives by reduction, and from 5-membered rings e.g., prolinol derivatives by ring expansion, from linear amines by cyclization or from dienes/dienophiles by [4 + 2]-cycloaddition.

Cumulant generating function formula of heat transfer in ballistic systems with lead-lead coupling

Science.gov (United States)

Li, Huanan; Agarwalla, Bijay Kumar; Wang, Jian-Sheng

2012-10-01

Based on a two-time observation protocol, we consider heat transfer in a given time interval tM in a lead-junction-lead system taking coupling between the leads into account. In view of the two-time observation, consistency conditions are carefully verified in our specific family of quantum histories. Furthermore, its implication is briefly explored. Then using the nonequilibrium Green's function method, we obtain an exact formula for the cumulant generating function for heat transfer between the two leads, valid in both transient and steady-state regimes. Also, a compact formula for the cumulant generating function in the long-time limit is derived, for which the Gallavotti-Cohen fluctuation symmetry is explicitly verified. In addition, we briefly discuss Di Ventra's repartitioning trick regarding whether the repartitioning procedure of the total Hamiltonian affects the nonequilibrium steady-state current fluctuation. All kinds of properties of nonequilibrium current fluctuations, such as the fluctuation theorem in different time regimes, could be readily given according to these exact formulas.

Analytic derivation of the leading-order gluon distribution function G(x,Q2)=xg(x,Q2) from the proton structure function F2p(x,Q2)

International Nuclear Information System (INIS)

Block, Martin M.; Durand, Loyal; McKay, Douglas W.

2008-01-01

We derive a second-order linear differential equation for the leading-order gluon distribution function G(x,Q 2 )=xg(x,Q 2 ) which determines G(x,Q 2 ) directly from the proton structure function F 2 p (x,Q 2 ). This equation is derived from the leading-order evolution equation for F 2 p (x,Q 2 ), and does not require knowledge of either the individual quark distributions or the gluon evolution equation. Given an analytic expression that successfully reproduces the known experimental data for F 2 p (x,Q 2 ) in a domain x min (Q 2 )≤x≤x max (Q 2 ), Q min 2 ≤Q 2 ≤Q max 2 of the Bjorken variable x and the virtuality Q 2 in deep inelastic scattering, G(x,Q 2 ) is uniquely determined in the same domain. We give the general solution and illustrate the method using the recently proposed Froissart-bound-type parametrization of F 2 p (x,Q 2 ) of E. L. Berger, M. M. Block and C.-I. Tan [Phys. Rev. Lett. 98, 242001 (2007)]. Existing leading-order gluon distributions based on power-law descriptions of individual parton distributions agree roughly with the new distributions for x > or approx. 10 -3 as they should, but are much larger for x -3 .

Narrative empathy and illness memoirs: Arthur Frank's At the Will of the Body and Kathlyn Conway's Ordinary Life.

Science.gov (United States)

Baena, Rosalia

2017-09-01

This article analyses the concept of narrative empathy in illness memoirs. These texts negotiate the narrative identity of an autobiographer as he or she recounts the disruptive experience of illness, an experience in which physical and emotional traces dramatically and definitively shape our sense of self. While narrative emotions are certainly deployed in these autobiographies in order to connect with the readers and promote social change, this empathic connection is not so much aimed at arousing compassion but rather more positive emotions on the experience of illness. I will explore the emotional representations of cancer in Arthur Frank's At the Will of the Body (1991) and Kathlyn Conway's Ordinary Life: A Memoir of Illness (1997), focusing on the identity strategies these authors use in order to become affirmative models of disability and illness, showing the damaging effects not of disease or impairment but, rather, of the cultural mythologies that interpret those conditions in reductive or disparaging ways. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Popular Science and Apocalyptic Narrative in Frank Schätzing’s The Swarm

Directory of Open Access Journals (Sweden)

Gabriele Dürbeck

2012-01-01

Full Text Available This paper analyses the use of the rhetoric of the Apocalypse and the concept of nature's revenge in Frank Schätzing's eco-thriller The Swarm. Ecocritical research has identified these narrative patterns as characteristic of contemporary environmental literature. In The Swarm, the apocalyptical rhetoric fulfils the double function of providing thrill and pleasure to the readers and warning them about imminent environmental peril, thereby combining conventions from the two genres of eco-thriller and science fiction. Contrasting reviews have described the novel as either enlightening or pseudo-religious. This ambivalence is the effect of various strategies employed to popularise scientific knowledge in the novel. The narrative embraces various scientific fields, for example the depiction of a network in contrast to swarm theory. The key conflict in the story embodies conflicting concepts of nature - anthropocentric vs. eco-systemic - which are represented by two contrasting groups of characters: one aiming to extinguish the alien superorganism that attacks the human race, the other aspiring to integrate the alien organism into the human world and propagating a holistic view of the Earth. The concepts of a 'tragic' and a 'comical apocalypse' correspond to the double closure which first features a show-down, the annihilation of the 'bad' characters, and then, in the epilogue, a warning message delivered by a 'good' character which confirms - in contrast to, for example, Michael Crichton's State of Fear - the ongoing environmental crisis. Although the epilogue extensively appeals to the human ability to rethink attitudes towards nature, the novel's support for environmental concerns is limited, not only because this message remains rather abstract but also because the vision of a reconciled, pseudo-religious ecosystem as a holistic superorganism has a highly ambivalent meaning for humanity.

The world’s first pelletized cold neutron moderator at a neutron scattering facility

Energy Technology Data Exchange (ETDEWEB)

Ananiev, V.; Belyakov, A.; Bulavin, M.; Kulagin, E.; Kulikov, S.; Mukhin, K.; Petukhova, T.; Sirotin, A.; Shabalin, D.; Shabalin, E.; Shirokov, V.; Verhoglyadov, A., E-mail: verhoglyadov_al@mail.ru

2014-02-01

In July 10, 2012 cold neutrons were generated for the first time with the unique pelletized cold neutron moderator CM-202 at the IBR-2M reactor. This new moderator system uses small spherical beads of a solid mixture of aromatic hydrocarbons (benzene derivatives) as the moderating material. Aromatic hydrocarbons are known as the most radiation-resistant hydrogenous substances and have properties to moderate slow neutrons effectively. Since the new moderator was put into routine operation in September 2013, the IBR-2 research reactor of the Frank Laboratory of Neutron Physics has consolidated its position among the world’s leading pulsed neutron sources for investigation of matter with neutron scattering methods.

Vectorcardiographic diagnostic & prognostic information derived from the 12-lead electrocardiogram: Historical review and clinical perspective.

Science.gov (United States)

Man, Sumche; Maan, Arie C; Schalij, Martin J; Swenne, Cees A

2015-01-01

In the course of time, electrocardiography has assumed several modalities with varying electrode numbers, electrode positions and lead systems. 12-lead electrocardiography and 3-lead vectorcardiography have become particularly popular. These modalities developed in parallel through the mid-twentieth century. In the same time interval, the physical concepts underlying electrocardiography were defined and worked out. In particular, the vector concept (heart vector, lead vector, volume conductor) appeared to be essential to understanding the manifestations of electrical heart activity, both in the 12-lead electrocardiogram (ECG) and in the 3-lead vectorcardiogram (VCG). Not universally appreciated in the clinic, the vectorcardiogram, and with it the vector concept, went out of use. A revival of vectorcardiography started in the 90's, when VCGs were mathematically synthesized from standard 12-lead ECGs. This facilitated combined electrocardiography and vectorcardiography without the need for a special recording system. This paper gives an overview of these historical developments, elaborates on the vector concept and seeks to define where VCG analysis/interpretation can add diagnostic/prognostic value to conventional 12-lead ECG analysis. Copyright © 2015 Elsevier Inc. All rights reserved.

Frank Wollman v kontextu strukturální teorie a terénních výzkumů slovesného folkloru (Příspěvek k nálezu tzv. wollmanovského moravského sběru)

Czech Academy of Sciences Publication Activity Database

Zelenková, Anna

2017-01-01

Roč. 104, č. 4 (2017), s. 493-509 ISSN 0009-0794 Institutional support: RVO:68378017 Keywords : Wollman, Frank * Czech and Slovak folklore studies * the structural theory of folklore * Moravian collection of folk verbal art Subject RIV: AJ - Letters, Mass-media, Audiovision OBOR OECD: Literary theory

Depressed Frank-Starling mechanism in the left ventricular muscle of the knock-in mouse model of dilated cardiomyopathy with troponin T deletion mutation ΔK210.

Science.gov (United States)

Inoue, Takahiro; Kobirumaki-Shimozawa, Fuyu; Kagemoto, Tatsuya; Fujii, Teruyuki; Terui, Takako; Kusakari, Yoichiro; Hongo, Kenichi; Morimoto, Sachio; Ohtsuki, Iwao; Hashimoto, Kazuhiro; Fukuda, Norio

2013-10-01

It has been reported that the Frank-Starling mechanism is coordinately regulated in cardiac muscle via thin filament "on-off" equilibrium and titin-based lattice spacing changes. In the present study, we tested the hypothesis that the deletion mutation ΔK210 in the cardiac troponin T gene shifts the equilibrium toward the "off" state and accordingly attenuate the sarcomere length (SL) dependence of active force production, via reduced cross-bridge formation. Confocal imaging in isolated hearts revealed that the cardiomyocytes were enlarged, especially in the longitudinal direction, in ΔK210 hearts, with striation patterns similar to those in wild type (WT) hearts, suggesting that the number of sarcomeres is increased in cardiomyocytes but the sarcomere length remains unaltered. For analysis of the SL dependence of active force, skinned muscle preparations were obtained from the left ventricle of WT and knock-in (ΔK210) mice. An increase in SL from 1.90 to 2.20μm shifted the mid-point (pCa50) of the force-pCa curve leftward by ~0.21pCa units in WT preparations. In ΔK210 muscles, Ca(2+) sensitivity was lower by ~0.37pCa units, and the SL-dependent shift of pCa50, i.e., ΔpCa50, was less pronounced (~0.11pCa units), with and without protein kinase A treatment. The rate of active force redevelopment was lower in ΔK210 preparations than in WT preparations, showing blunted thin filament cooperative activation. An increase in thin filament cooperative activation upon an increase in the fraction of strongly bound cross-bridges by MgADP increased ΔpCa50 to ~0.21pCa units. The depressed Frank-Starling mechanism in ΔK210 hearts is the result of a reduction in thin filament cooperative activation. © 2013.

El Guggenheim Museum de New York. Interpretación del papel de la estructura a través de la colaboración entre Frank Lloyd Wright y Jaroslav J. Polivka

OpenAIRE

Martin Saiz, Diego

2012-01-01

Arquitectura y estructura han ido siempre íntimamente ligadas, pero con la aparición del acero y el hormigón surgieron nuevas necesidades formales o estéticas. El Estilo Internacional se inclinó por separar la retícula estructural de los cerramientos. En cambio, la Escuela de Chicago forjó las bases de una arquitectura optimizada y racional. Frank Lloyd Wright, entre estas dos situaciones, optó por seguir las pautas naturales de los materiales, de forma “orgánica”, recuperan...

76 FR 12888 - Registration of Intermediaries

Science.gov (United States)

2011-03-09

... Transaction Execution Facilities The Dodd-Frank Act abolished derivatives transaction execution facilities as... the operation of this section may file a petition with the Secretary of the Commission, which petition...

75 FR 57384 - Rescission of Rules Pertaining to the Payment of Bounties for Information Leading to the Recovery...

Science.gov (United States)

2010-09-21

.... SUPPLEMENTARY INFORMATION: The Insider Trading and Securities Fraud Enforcement Act of 1988 authorized the... SECURITIES AND EXCHANGE COMMISSION 17 CFR Part 201 [Release No. 34-62921] Rescission of Rules... Trading AGENCY: Securities and Exchange Commission. ACTION: Final rule. SUMMARY: The Dodd-Frank Wall...

Anti-Hemagglutinin Antibody Derived Lead Peptides for Inhibitors of Influenza Virus Binding.

Directory of Open Access Journals (Sweden)

Henry Memczak

Full Text Available Antibodies against spike proteins of influenza are used as a tool for characterization of viruses and therapeutic approaches. However, development, production and quality control of antibodies is expensive and time consuming. To circumvent these difficulties, three peptides were derived from complementarity determining regions of an antibody heavy chain against influenza A spike glycoprotein. Their binding properties were studied experimentally, and by molecular dynamics simulations. Two peptide candidates showed binding to influenza A/Aichi/2/68 H3N2. One of them, termed PeB, with the highest affinity prevented binding to and infection of target cells in the micromolar region without any cytotoxic effect. PeB matches best the conserved receptor binding site of hemagglutinin. PeB bound also to other medical relevant influenza strains, such as human-pathogenic A/California/7/2009 H1N1, and avian-pathogenic A/Mute Swan/Rostock/R901/2006 H7N1. Strategies to improve the affinity and to adapt specificity are discussed and exemplified by a double amino acid substituted peptide, obtained by substitutional analysis. The peptides and their derivatives are of great potential for drug development as well as biosensing.

Li{sub 12}Cu{sub 12.60}Al{sub 14.37}. A new ternary derivative of the binary Laves phases

Energy Technology Data Exchange (ETDEWEB)

Pavlyuk, Volodymyr [Ivan Franko Lviv National Univ. (Ukraine). Dept. of Inorganic Chemistry; Jan Dlugosz Univ., Czestochowa (Poland). Inst. of Chemistry, Environment Protection and Biotechnology; Dmytriv, Grygoriy; Tarasiuk, Ivan [Ivan Franko Lviv National Univ. (Ukraine). Dept. of Inorganic Chemistry; Chumak, Ihor [IFW Dresden (Germany); Ehrenberg, Helmut [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany). Inorganic Chemistry

2011-12-15

New ternary dodecalithium dodecacopper tetradecaaluminium, Li{sub 12}Cu{sub 12.60}Al{sub 14.37} (trigonal, R anti 3m, hR39), crystallizes as a new structure type and belongs to the structural family that derives from binary Laves phases. The Li atoms are enclosed in 15- and 16-vertex and the Al3 atom in 14-vertex pseudo-Frank-Kasper polyhedra. The polyhedra around the statistical mixtures of (Cu,Al)1 and (Al,Cu)2 are distorted icosahedra. The electronic structure was calculated by the TB- LMTO-ASA (tight-binding linear muffin-tin orbital atomic spheres approximation) method. The electron localization function, which indicates bond formation, is mostly located at the Al atoms. Thus, Al-Al bonding is much stronger than Li-Al or Cu-Al bonding. This indicates that, besides metallic bonding which is dominant in this compound, weak covalent Al-Al interactions also exist. (orig.)

Lead adsorption study on combustion derived γ-Fe2O3 surface

Indian Academy of Sciences (India)

2016-08-26

AAS) and solution conductivity (SC). Reduction in the concentration and increase in conductance of eluent lead solution is observed. The potential use of solid adsorbents for the adsorption of heavy metal pollutants is envisaged ...

Estimating the burden of disease attributable to lead exposure in ...

African Journals Online (AJOL)

Objectives. To estimate the burden of disease attributable to lead exposure in South Africa in 2000. Design. World Health Organization comparative risk assessment (CRA) methodology was followed. Recent community studies were used to derive mean blood lead concentrations in adults and children in urban and rural ...

The Politics of Genre and Medium apropos of Frank O’Hara’s “On Seeing Larry Rivers’s Washington Crossing the Delaware (1955)

DEFF Research Database (Denmark)

Balle, Søren Hattesen

Frank O’Hara’s ekphrastic poem “On Seeing Larry Rivers’s Washington Crossing the Delaware” is only one work among others in a series of 1950s works in different genres and media relating to Emanuel Leutze’s romantic representation of the father of the American nation in his painting Washington...... event in American history. Inversely, only few critics take seriously the difference in both genre and medium between these different textual and graphic representations of Washington’s crossing and the questions such a difference may give rise to. In this paper I shall make an intergeneric......) and by narrativizing Rivers’s painting, the poem opens up alternative representational possibilities of the former and thus poses the question of whose ‘truth’ gets told or not told depending on the choice of genre and medium in representation. Thus, the intertextual relationship existing between Rivers’s painting...

Resolution of lead-210 chronologies in lake sediments: problems of mid-core fluctuations in lead-210/radium-226 ratios

Energy Technology Data Exchange (ETDEWEB)

Haworth, R. [New England Univ., Armidale, NSW (Australia). Dept. of Geography; Heijnis, H. [Australian Inst. of Nuclear Science and Engineering, Lucas Heights, NSW (Australia)

1997-12-31

With a range in excess of 150 years under optimum conditions, lead-210 dating represents a valuable tool for studying recent human impacts on the environment, particularly the effects of European settlement in Australia. It is therefore also useful for establishing the start of the pre-European record in a sediment profile. Despite these advantages, there are some unresolved problems that prevent the full potential of an atmospherically-derived lead-210 profile being extended as far into the past as the activity signal allows. lead 210 has a half-life of 22.26 years, and a capacity to precipitate and be adsorbed by terrestrial material, particularly lake and marine sediments. This out-of-phase (or unsupported) lead-210 thus returns to a specific terrigenous location where it is added to the lead- 210 formed continuously in situ from the local radium-226 (equivalent to supported lead-210). Dating is based on the measurement of the decline of this unsupported lead-210 against the equilibrium ratio of in situ lead-210/radium-226. Paper no. 13; Extended abstract. 2 refs., 1 fig.

Resolution of lead-210 chronologies in lake sediments: problems of mid-core fluctuations in lead-210/radium-226 ratios

International Nuclear Information System (INIS)

Haworth, R.

1997-01-01

With a range in excess of 150 years under optimum conditions, lead-210 dating represents a valuable tool for studying recent human impacts on the environment, particularly the effects of European settlement in Australia. It is therefore also useful for establishing the start of the pre-European record in a sediment profile. Despite these advantages, there are some unresolved problems that prevent the full potential of an atmospherically-derived lead-210 profile being extended as far into the past as the activity signal allows. lead 210 has a half-life of 22.26 years, and a capacity to precipitate and be adsorbed by terrestrial material, particularly lake and marine sediments. This out-of-phase (or unsupported) lead-210 thus returns to a specific terrigenous location where it is added to the lead- 210 formed continuously in situ from the local radium-226 (equivalent to supported lead-210). Dating is based on the measurement of the decline of this unsupported lead-210 against the equilibrium ratio of in situ lead-210/radium-226

Preparation of 7-substituted ginkgolide derivatives

DEFF Research Database (Denmark)

Vogensen, Stine Byskov; Strømgaard, Kristian; Shindou, Hideo

2003-01-01

alpha-fluoro ginkgolide B was equipotent to ginkgolide B underlining the critical importance of the 7-position of ginkgolides for PAF receptor activity. Herein we describe the synthesis of a series of ginkgolide B derivatives with modifications at the 7-position and the pharmacological evaluation...... of these derivatives as assayed by cloned PAF receptors. In two cases nucleophilic attack on a 7beta-O-triflate ginkgolide B did not lead to the expected products, but gave rise to two unprecedented ginkgolide derivatives, one with a novel rearranged skeleton. Furthermore, standard reduction of 7alpha-azido ginkgolide......-chloro ginkgolide B, the most potent nonaromatic ginkgolide derivative described to date with a K(i) value of 110 nM....

Non-Linear Optical Studies On Sol-Gel Derived Lead Chloride Crystals Using Z-Scan Technique

OpenAIRE

Rejeena, I; Lillibai, B; Toms, Roseleena; Nampoori, VP N; Radhakrishnan, P

2014-01-01

In this paper we report the preparation, optical characterization and non linear optical behavior of pure lead chloride crystals. Lead chloride samples subjected to UV and IR irradiation and electric and magnetic fields have also been investigated Optical nonlinearity in these lead chloride samples were determined using single beam and high sensitive Z-scan technique. Non linear optical studies of these materials in single distilled water show reverse saturable absorption which makes th...

Accelerated approach of discovering plant derived drug leads for treatment of TB

CSIR Research Space (South Africa)

Naidoo, D

2010-06-01

Full Text Available dedicated and comprehensive plant electronic database of a total of 566 plants that are reportedly used for the treatment of tuberculosis. The extracts of these plants are part of the CSIR database of extracts. TB drug lead research is ongoing, and active...

State-Space Modelling of Loudspeakers using Fractional Derivatives

DEFF Research Database (Denmark)

King, Alexander Weider; Agerkvist, Finn T.

2015-01-01

This work investigates the use of fractional order derivatives in modeling moving-coil loudspeakers. A fractional order state-space solution is developed, leading the way towards incorporating nonlinearities into a fractional order system. The method is used to calculate the response of a fractio......This work investigates the use of fractional order derivatives in modeling moving-coil loudspeakers. A fractional order state-space solution is developed, leading the way towards incorporating nonlinearities into a fractional order system. The method is used to calculate the response...... of a fractional harmonic oscillator, representing the mechanical part of a loudspeaker, showing the effect of the fractional derivative and its relationship to viscoelasticity. Finally, a loudspeaker model with a fractional order viscoelastic suspension and fractional order voice coil is fit to measurement data...

Stable lead isotopes and lake sediments. A useful combination for the study of atmospheric lead pollution history

Energy Technology Data Exchange (ETDEWEB)

Renberg, I.; Braennvall, M.-L.; Bindler, R. [Department of Ecology and Environmental Science, Umea University, SE-901 87 Umea (Sweden); Emteryd, O. [Department of Forest Ecology, Swedish University of Agricultural Sciences, SE-901 83 Umea (Sweden)

2002-06-20

Analysis of stable lead isotopes and lead concentrations in lake-sediment deposits, not least in varved (annually-laminated) sediments, is a useful method to study lead pollution history. This paper presents details from a study of 31 lakes in Sweden. Using a strong acid digestion of sediment samples and ICP-MS analyses, we have found that Swedish lake sediments have a high natural (pre-pollution) 206[Pb]/207[Pb] ratio (mean 1.52{+-}0.18, range 1.28-2.01, n=31 lakes). In contrast, atmospheric lead pollution derived from metal smelting processes, coal burning and from alkyl-lead added to petrol has a lower ratio (<1.2). Consequently, when pollution lead deposition began approximately 3500 years ago, the lead isotope ratio of the sediments started to decline, and in modern sediments it is typically <1.2. Using the isotope and concentration values and a mixing model, the relative contribution of pollution and natural lead in sediment samples can be calculated. The pollution lead records of the Swedish lake sediments show a consistent picture of the atmospheric lead pollution history. Some noticeable features are the Roman peak, the large and permanent Medieval increase, peaks at approximately 1200 and 1530 ad, the rapid increase after World War II, the peak in the 1970s, and the large modern decline.

Separation of [Rh-103m]-rhodocene-derivatives from the parent [103Ru]ruthenocen-derivatives and their organ distribution

International Nuclear Information System (INIS)

Wenzel, M.; Wu, Y.

1987-01-01

The radioactive decay of [ 103 Ru]ruthenocene derivatives leads to sup(103m)Rh labelled rhodocinium derivatives, which can be separated by the extraction of a lipophilic solution of the ruthenocen derivate with water. The separation factor sup(103m)Rh/ 103 Ru reaches values of 32:1 Rh 3+ ions are not liberated and extracted. The organ distribution of the sup(103m)Rh labelled rhodocinium derivatives gained from ruthenocene and from N-isopropyl-ruthenocene amphetamine is different from the distribution of the parent ruthenocene compound. The liver and kidney uptake of the rhodocinium-amphetamine is much higher than the uptake with ruthenocene amphetamine. (author)

Biological characterization of lead-enhanced exopolysaccharide produced by a lead resistant Enterobacter cloacae strain P2B.

Science.gov (United States)

Naik, Milind Mohan; Pandey, Anju; Dubey, Santosh Kumar

2012-09-01

A lead resistant bacterial strain isolated from effluent of lead battery manufacturing company of Goa, India has been identified as Enterobacter cloacae strain P2B based on morphological, biochemical characters, FAME profile and 16S rDNA sequence data. This bacterial strain could resist lead nitrate up to 1.6 mM. Significant increase in exopolysaccharide (EPS) production was observed as the production increased from 28 to 108 mg/L dry weight when exposed to 1.6 mM lead nitrate in Tris buffered minimal medium. Fourier-transformed infrared spectroscopy of this EPS revealed presence of several functional groups involved in metal binding viz. carboxyl, hydroxyl and amide groups along with glucuronic acid. Gas chromatography coupled with mass spectrometry analysis of alditol-acetate derivatives of acid hydrolysed EPS produced in presence of 1.6 mM lead nitrate demonstrated presence of several neutral sugars such as rhamnose, arabinose, xylose, mannose, galactose and glucose, which contribute to lead binding hydroxyl groups. Scanning electron microscope coupled with energy dispersive X-ray spectrometric analysis of this lead resistant strain exposed to 1.6 mM lead nitrate interestingly revealed mucous EPS surrounding bacterial cells which sequestered 17 % lead (as weight %) extracellularly and protected the bacterial cells from toxic effects of lead. This lead resistant strain also showed multidrug resistance. Thus these results significantly contribute to better understanding of structure, function and environmental application of lead-enhanced EPSs produced by bacteria. This lead-enhanced biopolymer can play a very important role in bioremediation of several heavy metals including lead.

Lead isotope in mineral exploration

International Nuclear Information System (INIS)

Gulson, B.L.

1986-01-01

This book provides an up-to-date state-of-the-art review of lead isotopes in mineral exploration. Beginning with an historical review on suggested uses of lead isotopes in mineral exploration, the author then outlines the theoretical aspects of lead isotopes and illustrates that the method is based on well-known principles of radioactive decay, from which isotopic signatures for different styles of mineralization are derived. The varying isotopic signatures are then introduced. The major part of the book details over 40 case histories for base and precious metals, uranium and tin using sampling media such as sulfides, gossans, soils, weathered bedrock, vegetation and groundwaters. Advantages and disadvantages of each are discussed. Examples are given of the use of lead isotopes in testing conceptual models for exploration. The success rate and cost-effectiveness of the method are illustrated by actual exploration examples. Analytical advances which should lower the cost of the method and future uses are outlined. Many of the case histories use recently published or unpublished data, 27 tables of which are given in an appendix. Details of sampling, the methods for obtaining the isotope ratios, and a commercially-available integrated lead isotope service are also provided. (Auth.)

Discriminating background from anthropogenic lead by isotopic methods

International Nuclear Information System (INIS)

Nelson, B.K.; O'Brien, H.E.

1995-01-01

The goal of this pilot project was to evaluate the practicality of using natural variations in the isotopic composition of lead to test for the presence of anthropogenic lead in soil, surface water and ground water. Complex chemical reactions in the environment may cause measured lead concentrations to be ambiguous indicators of anthropogenic lead component. The lead isotope tracer technique has the potential to identify both the presence and proportion of anthropogenic lead in the environment. The tested the lead isotope technique at Eielson Air Force Base, Alaska, on sources of suspected fuel contamination. Although the results are specific to this base, the general technique of using lead isotopes to trace the movement of anthropogenic lead is applicable to other CERCLA sites. The study had four objectives: (1) characterize the natural lead isotope composition of bedrock, stream sediment and soils; (2) characterize the isotopic composition of the contaminant lead derived from fuel; (3) evaluate the sensitivity of the isotopic method to distinguishing between anthropogenic and natural lead in soil and water samples and (4) evaluate the analytical feasibility and accuracy of the method at the Isotope Geochemistry Laboratory at the University of Washington

Leading change: a concept analysis.

Science.gov (United States)

Nelson-Brantley, Heather V; Ford, Debra J

2017-04-01

To report an analysis of the concept of leading change. Nurses have been called to lead change to advance the health of individuals, populations, and systems. Conceptual clarity about leading change in the context of nursing and healthcare systems provides an empirical direction for future research and theory development that can advance the science of leadership studies in nursing. Concept analysis. CINAHL, PubMed, PsycINFO, Psychology and Behavioral Sciences Collection, Health Business Elite and Business Source Premier databases were searched using the terms: leading change, transformation, reform, leadership and change. Literature published in English from 2001 - 2015 in the fields of nursing, medicine, organizational studies, business, education, psychology or sociology were included. Walker and Avant's method was used to identify descriptions, antecedents, consequences and empirical referents of the concept. Model, related and contrary cases were developed. Five defining attributes of leading change were identified: (a) individual and collective leadership; (b) operational support; (c) fostering relationships; (d) organizational learning; and (e) balance. Antecedents were external or internal driving forces and organizational readiness. The consequences of leading change included improved organizational performance and outcomes and new organizational culture and values. A theoretical definition and conceptual model of leading change were developed. Future studies that use and test the model may contribute to the refinement of a middle-range theory to advance nursing leadership research and education. From this, empirically derived interventions that prepare and enable nurses to lead change to advance health may be realized. © 2016 John Wiley & Sons Ltd.

U12, a UDCA derivative, acts as an anti-hepatoma drug lead and inhibits the mTOR/S6K1 and cyclin/CDK complex pathways.

Directory of Open Access Journals (Sweden)

Yang Xu

Full Text Available U12, one of 20 derivatives synthesized from ursodeoxycholic acid (UDCA, has been found to have anticancer effects in liver cancer cell lines (SMMC-7721 and HepG2 and to protect normal liver cells from deoxycholic acid (DCA damage (QSG-7701. Its anticancer mechanism was investigated using computer-aided network pharmacology and comparative proteomics. Results showed that its anti-malignancy activities were activated by mTOR/S6K1, cyclinD1/CDK2/4 and caspase-dependent apoptotic signaling pathways in hepatocellular carcinoma cells (HCC. The action of U12 may be similar to that of rapamycin. Animal testing confirmed that U12 exerted better anti-tumor activity than UDCA and had less severe side effects than fluorouracil (5-Fu. These observations indicate that U12 differs from UDCA and other derivatives and may be a suitable lead for the development of compounds useful in the treatment of HCC.

Kinetic Theory Derivation of the Adiabatic Law for Ideal Gases.

Science.gov (United States)

Sobel, Michael I.

1980-01-01

Discusses how the adiabatic law for ideal gases can be derived from the assumption of a Maxwell-Boltzmann (or any other) distribution of velocities--in contrast to the usual derivations from thermodynamics alone, and the higher-order effect that leads to one-body viscosity. An elementary derivation of the adiabatic law is given. (Author/DS)

Separation of (Rh-103m)-rhodocene-derivatives from the parent (/sup 103/Ru)ruthenocen-derivatives and their organ distribution

Energy Technology Data Exchange (ETDEWEB)

Wenzel, M.; Wu, Y.

1987-01-01

The radioactive decay of (/sup 103/Ru)ruthenocene derivatives leads to sup(103m)Rh labelled rhodocinium derivatives, which can be separated by the extraction of a lipophilic solution of the ruthenocen derivate with water. The separation factor sup(103m)Rh//sup 103/Ru reaches values of 32:1 Rh/sup 3 +/ ions are not liberated and extracted. The organ distribution of the sup(103m)Rh labelled rhodocinium derivatives gained from ruthenocene and from N-isopropyl-ruthenocene amphetamine is different from the distribution of the parent ruthenocene compound. The liver and kidney uptake of the rhodocinium-amphetamine is much higher than the uptake with ruthenocene amphetamine.

Derivation of GFDM Based on OFDM Principles

Energy Technology Data Exchange (ETDEWEB)

Hussein Moradi; Behrouz Farhang-Boroujeny

2015-06-01

This paper starts with discussing the principle based on which the celebrated orthogonal frequency division multiplexing (OFDM) signals are constructed. It then extends the same principle to construct the newly introduced generalized frequency division multiplexing (GFDM) signals. This novel derivation sheds light on some interesting properties of GFDM. In particular, our derivation seamlessly leads to an implementation of GFDM transmitter which has significantly lower complexity than what has been reported so far. Our derivation also facilitates a trivial understanding of how GFDM (similar to OFDM) can be applied in MIMO channels.

Mechanism of Platinum Derivatives Induced Kidney Injury

Directory of Open Access Journals (Sweden)

Feifei YAN

2015-09-01

Full Text Available Platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors, lung cancer, and colorectal cancer. Two major problems exist, however, in the clinic use of platinum derivatives. One is the development of tumor resistance to the drug during therapy, leading to treatment failure. The other is the drug’s toxicity such as the cisplatin’s nephrotoxicity, which limits the dose that can be administered. This paper describes the mechanism of platinum derivatives induced kidney injury.

Stable lead isotopic analyses of historic and contemporary lead contamination of San Francisco Bay estuary

Science.gov (United States)

Ritson, P.I.; Bouse, R.M.; Flegal, A.R.; Luoma, S.N.

1999-01-01

Variations in stable lead isotopic composition (240Pb, 206Pb, 207Pb, 208Pb) in three sediment cores from the San Francisco Bay estuary document temporal changes in sources of lead during the past two centuries. Sediment, with lead from natural geologic sources, and relatively homogeneous lead isotopic compositions are overlain by sediments whose isotopic compositions indicate change in the sources of lead associated with anthropogenic modification of the estuary. The first perturbations of lead isotopic composition in the cores occur in the late 1800s concordant with the beginning of industrialization around the estuary. Large isotopic shifts, toward lower 206Pb/207Pb, occur after the turn of the century in both Richardson and San Pablo Bays. A similar relationship among lead isotopic compositions and lead concentrations in both Bays suggest contamination from the same source (a lead smelter). The uppermost sediments (post 1980) of all cores also have a relatively homogenous lead isotopic composition distinct from pre-anthropogenic and recent aerosol signatures. Lead isotopic compositions of leachates from fourteen surface sediments and five marsh samples from the estuary were also analyzed. These analyses suggest that the lead isotopic signature identified in the upper horizons of the cores is spatially homogeneous among recently deposited sediments throughout the estuary. Current aerosol lead isotopic compositions [Smith, D.R., Niemeyer, S., Flegal, A.R., 1992. Lead sources to California sea otters: industrial inputs circumvent natural lead biodepletion mechanisms. Environmental Research 57, 163-175] are distinct from the isotopic compositions of the surface sediments, suggesting that the major source of lead is cycling of historically contaminated sediments back through the water column. Both the upper core sediments and surface sediments apparently derive their lead predominantly from sources internal to the estuary. These results support the idea that

Radiation Induced Removal of Stacking Faults in Quenched Aluminium

Energy Technology Data Exchange (ETDEWEB)

Bergenlid, U

1965-12-15

The effect of neutron irradiation on specimens of quenched aluminium containing Frank sessile dislocation loops has been studied by means of electron microscopy. The Frank loops were found to trans. form into perfect loops at doses less than 10{sup 17} nvt. A possible reason for the removal of the stacking faults is the displacement of a number of atoms at the faults, leading to the passage of a Shockley partial. Unfaulting induced by stress fields from dislocations, released during the irradiation, can also be important.

Radiation Induced Removal of Stacking Faults in Quenched Aluminium

International Nuclear Information System (INIS)

Bergenlid, U.

1965-12-01

The effect of neutron irradiation on specimens of quenched aluminium containing Frank sessile dislocation loops has been studied by means of electron microscopy. The Frank loops were found to trans. form into perfect loops at doses less than 10 17 nvt. A possible reason for the removal of the stacking faults is the displacement of a number of atoms at the faults, leading to the passage of a Shockley partial. Unfaulting induced by stress fields from dislocations, released during the irradiation, can also be important

Structure Activity Relationship of Brevenal Hydrazide Derivatives

Directory of Open Access Journals (Sweden)

Allan Goodman

2014-03-01

Full Text Available Brevenal is a ladder frame polyether produced by the dinoflagellate Karenia brevis. This organism is also responsible for the production of the neurotoxic compounds known as brevetoxins. Ingestion or inhalation of the brevetoxins leads to adverse effects such as gastrointestinal maladies and bronchoconstriction. Brevenal shows antagonistic behavior to the brevetoxins and shows beneficial attributes when administered alone. For example, in an asthmatic sheep model, brevenal has been shown to increase tracheal mucosal velocity, an attribute which has led to its development as a potential treatment for Cystic Fibrosis. The mechanism of action of brevenal is poorly understood and the exact binding site has not been elucidated. In an attempt to further understand the mechanism of action of brevenal and potentially develop a second generation drug candidate, a series of brevenal derivatives were prepared through modification of the aldehyde moiety. These derivatives include aliphatic, aromatic and heteroaromatic hydrazide derivatives. The brevenal derivatives were tested using in vitro synaptosome binding assays to determine the ability of the compounds to displace brevetoxin and brevenal from their native receptors. A sheep inhalation model was used to determine if instillation of the brevenal derivatives resulted in bronchoconstriction. Only small modifications were tolerated, with larger moieties leading to loss of affinity for the brevenal receptor and bronchoconstriction in the sheep model.

Carcinoma ex-pleomorphic adenoma derived from recurrent pleomorphic adenoma shows important difference by array CGH compared to recurrent pleomorphic adenoma without malignant transformation

Directory of Open Access Journals (Sweden)

Fernanda Viviane Mariano

Full Text Available Abstract Introduction: A key step of cancer development is the progressive accumulation of genomic changes resulting in disruption of several biological mechanisms. Carcinoma ex-pleomorphic adenoma (CXPA is an aggressive neoplasm that arises from a pleomorphic adenoma. CXPA derived from a recurrent PA (RPA has been rarely reported, and the genomic changes associated with these tumors have not yet been studied. Objective: We analyzed CXPA from RPAs and RPAs without malignant transformation using array-comparative genomic hybridization (array-CGH to identify somatic copy number alterations and affected genes. Methods: DNA samples extracted from FFPE tumors were submitted to array-CGH investigation, and data was analyzed by Nexus Copy Number Discovery Edition v.7. Results: No somatic copy number alterations were found in RPAs without malignant transformation. As for CXPA from RPA, although genomic profiles were unique for each case, we detected some chromosomal regions that appear to be preferentially affected by copy number alterations. The first case of CXPA-RPA (frankly invasive myoepithelial carcinoma showed copy number alterations affecting 1p36.33p13, 5p and chromosomes 3 and 8. The second case of CXPA-RPA (frankly invasive epithelial-myoepithelial carcinoma showed several alterations at chromosomes 3, 8, and 16, with two amplifications at 8p12p11.21 and 12q14.3q21.2. The third case of CXPA-RPA (minimally invasive epithelial-myoepithelial carcinoma exhibited amplifications at 12q13.3q14.1, 12q14.3, and 12q15. Conclusion: The occurrence of gains at chromosomes 3 and 8 and genomic amplifications at 8p and 12q, mainly those encompassing the HMGA2, MDM2, WIF1, WHSC1L1, LIRG3, CDK4 in CXAP from RPA can be a significant promotional factor in malignant transformation.

Minimally invasive estimation of ventricular dead space volume through use of Frank-Starling curves.

Directory of Open Access Journals (Sweden)

Shaun Davidson

Full Text Available This paper develops a means of more easily and less invasively estimating ventricular dead space volume (Vd, an important, but difficult to measure physiological parameter. Vd represents a subject and condition dependent portion of measured ventricular volume that is not actively participating in ventricular function. It is employed in models based on the time varying elastance concept, which see widespread use in haemodynamic studies, and may have direct diagnostic use. The proposed method involves linear extrapolation of a Frank-Starling curve (stroke volume vs end-diastolic volume and its end-systolic equivalent (stroke volume vs end-systolic volume, developed across normal clinical procedures such as recruitment manoeuvres, to their point of intersection with the y-axis (where stroke volume is 0 to determine Vd. To demonstrate the broad applicability of the method, it was validated across a cohort of six sedated and anaesthetised male Pietrain pigs, encompassing a variety of cardiac states from healthy baseline behaviour to circulatory failure due to septic shock induced by endotoxin infusion. Linear extrapolation of the curves was supported by strong linear correlation coefficients of R = 0.78 and R = 0.80 average for pre- and post- endotoxin infusion respectively, as well as good agreement between the two linearly extrapolated y-intercepts (Vd for each subject (no more than 7.8% variation. Method validity was further supported by the physiologically reasonable Vd values produced, equivalent to 44.3-53.1% and 49.3-82.6% of baseline end-systolic volume before and after endotoxin infusion respectively. This method has the potential to allow Vd to be estimated without a particularly demanding, specialised protocol in an experimental environment. Further, due to the common use of both mechanical ventilation and recruitment manoeuvres in intensive care, this method, subject to the availability of multi-beat echocardiography, has the potential to

Proceedings of the 22nd ACM conference on Hypertext and hypermedia

DEFF Research Database (Denmark)

and Ubiquitous Hypermedia, chaired by Niels Olof Bouvin and Frank Shipman; Social Media (Linking People and Things), chaired by Andreas Hotho, Gerd Stumme and Markus Strohmaier; Interaction, Narrative, and Storytelling, chaired by Mark Bernstein and Frank Nack. Three keynote speakers represent the breadth, depth....... Noshir Contractor investigates factors that lead to the formation, maintenance and dissolution of dynamically linked social and knowledge networks. The Program Committee and the reviewers worked hard to select an excellent program from 104 paper submissions. We accepted 31 full papers and 4 short papers...

BATCH AND FIXED BED ADSORPTION STUDIES OF LEAD (II CATIONS FROM AQUEOUS SOLUTIONS ONTO GRANULAR ACTIVATED CARBON DERIVED FROM MANGOSTANA GARCINIA SHELL

Directory of Open Access Journals (Sweden)

Zaira Zaman Chowdhury,

2012-05-01

Full Text Available The feasibility of granular activated carbon (GAC derived from Mangostene (Mangostana garcinia fruit shell to remove lead, Pb2+ cations was investigated in batch and fixed bed sorption systems. Batch experiments were carried out to study equilibrium isotherms, kinetics, and thermodynamics by using an initial lead (Pb2+ ions concentration of 50 to 100 mg/L at pH 5.5. Equilibrium data were fitted using Langmuir, Freundlich, and Temkin linear equation models at temperatures 30°C, 50°C, and 70°C. Langmuir maximum monolayer sorption capacity was 25.00 mg/g at 30°C. The experimental data were best represented by pseudo-second-order and Elovich models. The sorption process was found to be feasible, endothermic, and spontaneous. In column experiments, the effects of initial cation concentration (50 mg/L, 70 mg/L, and 100 mg/L, bed height (4.5 cm and 3 cm, and flow rate (1 mL/min and 3 mL/min on the breakthrough characteristics were evaluated. Breakthrough curves were further analyzed by using Thomas and Yoon Nelson models to study column dynamics. The column was regenerated and reused consecutively for four cycles. The result demonstrated that the prepared activated carbon was suitable for removal of Pb2+ from synthetic aqueous solution using batch, as well as fixed bed sorption systems.

Leading multi-soft limits from scattering equations

Science.gov (United States)

Zlotnikov, Michael

2017-10-01

A Cachazo-He-Yuan (CHY) type formula is derived for the leading gluon, bi-adjoint scalar ϕ 3, Yang-Mills-scalar and non-linear sigma model m-soft factors S m in arbitrary dimension. The general formula is used to evaluate explicit examples for up to three soft legs analytically and up to four soft legs numerically via comparison with amplitude ratios under soft kinematics. A structural pattern for gluon m-soft factor is inferred and a simpler formula for its calculation is conjectured. In four dimensions, a Cachazo-Svrček-Witten (CSW) recursive procedure producing the leading m-soft gluon factor in spinor helicity formalism is developed as an alternative, and Britto-Cachazo-Feng-Witten (BCFW) recursion is used to obtain the leading four-soft gluon factor for all analytically distinct helicity configurations.

Influence of pyrolysis temperature on lead immobilization by chemically modified coconut fiber-derived biochars in aqueous environments.

Science.gov (United States)

Wu, Weidong; Li, Jianhong; Niazi, Nabeel Khan; Müller, Karin; Chu, Yingchao; Zhang, Lingling; Yuan, Guodong; Lu, Kouping; Song, Zhaoliang; Wang, Hailong

2016-11-01

Biochar has received widespread attention as an eco-friendly and efficient material for immobilization of toxic heavy metals in aqueous environments. In the present study, three types of coconut fiber-derived biochars were obtained by pyrolyzing at three temperatures, i.e., 300, 500, and 700 °C. In addition, nine types of biochars were prepared by chemical modification with ammonia, hydrogen peroxide, and nitric acid, respectively, which were used to investigate changes in physico-chemical properties by inter alia, Fourier transformation infrared spectrophotometry (FTIR), scanning electron microscope (SEM), and BET specific surface area analysis. Batch sorption experiments were carried out to determine the sorption capacity of the biochars for lead (Pb) in aqueous solutions. Results showed that the cation exchange capacity of biochar pyrolyzed at 300 °C and modified with nitric acid increased threefold compared to the control. Loosely corrugated carbon surface and uneven carbon surface of the biochar pyrolyzed at 300 °C were produced during ammonia and nitric acid modifications. Removal rate of Pb by the coconut biochar pyrolyzed at 300 °C and modified with ammonia was increased from 71.8 to 99.6 % compared to the untreated biochar in aqueous solutions containing 100 mg L -1 Pb. However, chemical modification did not enhance adsorption of Pb of the biochars pyrolyzed at higher temperatures (e.g., 500 or 700 °C), indicating that resistance of biochars to chemical treatment increased with pyrolysis temperature.

Synthesis and Antibacterial Screening of Novel Derivatives of Embelin

Science.gov (United States)

Subramanian, L.; Leema, M.; Pradeep, N. S.; Joy, B.; Pillai, Z. S.

2018-02-01

Embelin, a naturally occurring compound extracted from Embelia ribes is used in Ayurvedic system of medicine owing to its wide spectrum of biological activities. In the present work, we have aimed at improving the efficacy of Embelin by appropriate structural modifications. A few novel derivatives of Embelin have been prepared. The antibacterial screening of these derivatives were carried out and compared with a well known antibiotic, Streptomycin. The derivatives exhibited better activity than Streptomycin and the lead molecule, Embelin.

Metric-affine formalism of higher derivative scalar fields in cosmology

International Nuclear Information System (INIS)

Li, Mingzhe; Wang, Xiulian

2012-01-01

Higher derivative scalar field theories have received considerable attention for the potentially explanations of the initial state of the universe or the current cosmic acceleration which they might offer. They have also attracted many interests in the phenomenological studies of infrared modifications of gravity. These theories are mostly studied by the metric variational approach in which only the metric is the fundamental field to account for the gravitation. In this paper we study the higher derivative scalar fields with the metric-affine formalism where the affine connection is treated arbitrarily at the beginning. Because the higher derivative scalar fields couple to the connection directly in a covariant theory these two formalisms will lead to different results. These differences are suppressed by the powers of the Planck mass and are usually expected to have small effects. But in some cases they may cause non-negligible deviations. We show by a higher derivative dark energy model that the two formalisms lead to significantly different pictures of the future universe

On the exponentiation of leading infrared divergences in massless Yang-Mills theories

International Nuclear Information System (INIS)

Frenkel, J.; Garcia, R.L.

1977-01-01

We derive, in the axial gauge, the effective U-matrix which governs the behaviour of leading infrared singularities in the self-energy functions of Yang-Mills particles. We then show in a very simple manner, that these divergences, which determine the leading singularities in massless Yang-Mills theories, exponentiate [pt

Preparation and optical characteristics of layered perovskite-type lead-bromide-incorporated azobenzene chromophores

International Nuclear Information System (INIS)

Sasai, Ryo; Shinomura, Hisashi

2013-01-01

Lead bromide-based layered perovskite powders with azobenzene derivatives were prepared by a homogeneous precipitation method. From the diffuse reflectance (DR) and photoluminescence (PL) spectra of the hybrid powder materials, the present hybrids exhibited sharp absorption and PL peaks originating from excitons produced in the PbBr 4 2− layer. When the present hybrid powder was irradiated with UV light at 350 nm, the absorption band from the trans-azobenzene chromophore, observed around 350 nm, decreased, while the absorption band from the cis-azobenzene chromophore, observed around 450 nm, increased. These results indicate that azobenzene chromophores in the present hybrid materials exhibit reversible photoisomerization. Moreover, it was found that the PL intensity from the exciton also varied due to photoisomerization of the azobenzene chromophores in the present hybrid. Thus, for the first time we succeeded in preparing the azobenzene derivative lead-bromide-based layered perovskite with photochromism before and after UV light irradiation. - Graphical abstract: For the first time, we succeeded in preparing the azobenzene derivative lead-bromide-based layered perovskite with photochromism before and after UV light irradiation. Highlights: ► PbBr-based layered perovskite with azobenezene derivatives could be synthesized by a homogeneous precipitation method. ► Azobenzene derivatives incorporated the present hybrid that exhibited reversible photoisomerization under UV and/or visible light irradiation. ► PL property of the present hybrid could also be varied by photoisomerization.

The influence of declining air lead levels on blood lead-air lead slope factors in children.

Science.gov (United States)

Richmond-Bryant, Jennifer; Meng, Qingyu; Davis, Allen; Cohen, Jonathan; Lu, Shou-En; Svendsgaard, David; Brown, James S; Tuttle, Lauren; Hubbard, Heidi; Rice, Joann; Kirrane, Ellen; Vinikoor-Imler, Lisa C; Kotchmar, Dennis; Hines, Erin P; Ross, Mary

2014-07-01

It is difficult to discern the proportion of blood lead (PbB) attributable to ambient air lead (PbA), given the multitude of lead (Pb) sources and pathways of exposure. The PbB-PbA relationship has previously been evaluated across populations. This relationship was a central consideration in the 2008 review of the Pb national ambient air quality standards. The objectives of this study were to evaluate the relationship between PbB and PbA concentrations among children nationwide for recent years and to compare the relationship with those obtained from other studies in the literature. We merged participant-level data for PbB from the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) and NHANES 9908 (1999-2008) with PbA data from the U.S. Environmental Protection Agency. We applied mixed-effects models, and we computed slope factor, d[PbB]/d[PbA] or the change in PbB per unit change in PbA, from the model results to assess the relationship between PbB and PbA. Comparing the NHANES regression results with those from the literature shows that slope factor increased with decreasing PbA among children 0-11 years of age. These findings suggest that a larger relative public health benefit may be derived among children from decreases in PbA at low PbA exposures. Simultaneous declines in Pb from other sources, changes in PbA sampling uncertainties over time largely related to changes in the size distribution of Pb-bearing particulate matter, and limitations regarding sampling size and exposure error may contribute to the variability in slope factor observed across peer-reviewed studies.

N-6 substituted deoxygenated derivatives of L-like 5'-noraristeromycin

African Journals Online (AJOL)

Several N-6 substituted derivatives (4-11) of (+)-4'-deoxy-5'-noraristeromycin (2) and its unsaturated counterpart (3) have been prepared. The derivatives are designed to systematically vary the hydrophobic/hydrophilic balance of the lead compounds. These compounds were evaluated against a large number of viruses but ...

Early Learning Visual Impairment Services Training and Advancement (EL VISTA) Project: Leading the Way for a New Profession within a Profession

Science.gov (United States)

Landa-Vialard, Olaya; Ely, Mindy S.; Lartz, Maribeth Nelson

2018-01-01

The Frank Porter Graham (FPG) Child Development Institute, Early Intervention Training Center for Infants and Toddlers with Visual Impairments and Their Families, University of North Carolina at Chapel Hill, was a national project that developed resources with the goal of building the capacity of colleges and universities to prepare personnel to…

The Role of Connectivity on Electronic Properties of Lead Iodide Perovskite-Derived Compounds

NARCIS (Netherlands)

Kamminga, Machteld E; De Wijs, Gilles; Havenith, Remco W A; Blake, Graeme R; Palstra, Thomas T M

2017-01-01

We use a layered solution crystal growth method to synthesize high-quality single crystals of two different benzylammonium lead iodide perovskite-like organic/inorganic hybrids. The well-known (C6H5CH2NH3)(2)PbI4 phase is obtained in the form of bright orange platelets, with a structure comprised of

A three-dimensional kinematic model for the dissolution of crystals

Science.gov (United States)

Tellier, C. R.

1989-06-01

The two-dimensional kinematic theory developed by Frank is extended into three dimensions. It is shown that the theoretical equations for the propagation vector associated with the displacement of a moving surface element can be directly derived from the polar equation of the slowness surface.

Effect of lead on heme synthesis

Energy Technology Data Exchange (ETDEWEB)

Neuberger, A.

1975-01-01

Recently, a fair amount of work has been done on the effect of lead on porphobilinogen dehydratase, which has been used as a sensitive indicator of lead poisoning. How far this is in itself harmful depends on the Michaelis constants of both the aminolaevulinic synthetase and of the dehydratase, and in addition on the relative activities of the two enzymes in a cell and also on the tissue concentration of glycine. Information on some of these points is still fragmentary, and a reliable judgement is at the present not very easy. Another step in the heme synthesis, which is sensitive to low concentrations of lead, is the incorporation of iron into protoporphyrin. Inhibition of this step may be important in accounting to a large extent for the anaemia found in individuals with lead poisoning. Reduction in the tissue concentration of heme or of heme-like compounds may also explain, through the mechanism of de-repression, the excretion of increased amounts of aminolaevulinic acid in the urine observed in cases of lead poisoning. A third step in heme synthesis, which might be sensitive to lead, is the oxidative decarboxylation of coproporphyrin to protoporphyrin, and this may explain why the former derivative is excreted in the urine. Recent work of the Harvard Medical School has indicated that greatly reduced levels of ALA dehydratase may be found in most cases of severe liver damage due to alcoholism. In most of these cases the level of lead in the blood is within normal limits, and there is no history of exposure to toxic amounts of lead. We therefore have to assume that a reduction in the blood level of this enzyme is not necessarily an indication of lead poisoning.

Structure-activity relationships of bumetanide derivatives

DEFF Research Database (Denmark)

Pedersen, Kasper Lykke; Töllner, Kathrin; Römermann, Kerstin

2015-01-01

of diuretics such as bumetanide. Bumetanide was discovered by screening ∼5000 3-amino-5-sulfamoylbenzoic acid derivatives, long before NKCC2 was identified in the kidney. Therefore, structure-activity studies on effects of bumetanide derivatives on NKCC2 are not available. EXPERIMENTAL APPROACH: In this study......, the effect of a series of diuretically active bumetanide derivatives was investigated on human NKCC2 variant A (hNKCC2A) expressed in Xenopus laevis oocytes. KEY RESULTS: Bumetanide blocked hNKCC2A transport with an IC50 of 4 μM. There was good correlation between the diuretic potency of bumetanide and its...... of the structural requirements that determine relative potency of loop diuretics on human NKCC2 splice variants, and may lead to the discovery of novel high-ceiling diuretics....

Supported Lead in Pb-210 Chronology

Energy Technology Data Exchange (ETDEWEB)

Pittauerova, D.; Hettwig, B.; Fischer, H. W. [Institute of Environmental Physics, University of Bremen, Bremen (Germany)

2013-07-15

A widely applied method of supported lead estimation in sediments using gamma spectrometric {sup 226}Ra determination via {sup 222}Rn short lived daughter products relies on radioactive equilibrium between {sup 226}Ra and {sup 222}Rn being established after sealing the samples. Advantages and disadvantages of methods of {sup 226}Ra estimation in sediments, using either {sup 222}Rn daughter products or direct estimation by 186.2 keV gamma emissions are discussed. An equilibrium experiment was performed using test samples and in one case radioactive equilibrium was not reached. On a theoretical sediment profile it was shown how systematic errors in supported {sup 210}Pb estimation can lead to incorrect interpretations of {sup 210}Pb{sub xs} profiles and therefore affect {sup 210}Pb derived chronologies. (author)

Lead isotopes and lead shot ingestion in the globally threatened marbled teal (Marmaronetta angustirostris) and white-headed duck (Oxyura leucocephala)

International Nuclear Information System (INIS)

Svanberg, Fredrik; Mateo, Rafael; Hillstroem, Lars; Green, Andy J.; Taggart, Mark A.; Raab, Andrea; Meharg, Andy A.

2006-01-01

Lead isotope ratios ( 206 Pb/ 207 Pb and 208 Pb/ 207 Pb) and concentrations in the livers and bones of marbled teal and white-headed duck found dead or moribund were determined in order to establish the main lead source in these waterfowl species. Lead concentrations in bone (dry weight) and liver (wet weight) were found to be very high in many of the white-headed ducks (bone: geometric mean = 88.9 ppm, maximum = 419 ppm; liver: geometric mean = 16.8 ppm, maximum = 57.0 ppm). Some of the marbled teal had high lead levels in the bones but liver lead levels were all low (bone: geometric mean = 6.13 ppm, maximum = 112 ppm; liver: geometric mean = 0.581 ppm, maximum = 4.77 ppm). Ingested lead shot were found in 71% of the white-headed duck and 20% of the marbled teal. The 206 Pb/ 207 Pb ratio in livers and bones of white-headed ducks and marbled teals showed no significant differences compared to the ratios obtained from lead shot. The 206 Pb/ 207 Pb ratio in bones of marbled teal ducklings with the highest lead concentrations tended to resemble the ratios of lead shot, which supports our hypothesis that the lead was derived from the hens. We also found that the lead ratios of lead shot and lead ratios described for soils in the area overlapped, but also that the isotopic ratio 206 Pb/ 207 Pb in lead shot used in Spain has a narrow range compared with those used in North America. The principal source of lead in many of these birds was, however, most likely lead shot, as supported by the similar isotopic ratios, high lead concentrations in tissues and evidence of ingested shot

Lead isotopes and lead shot ingestion in the globally threatened marbled teal (Marmaronetta angustirostris) and white-headed duck (Oxyura leucocephala)

Energy Technology Data Exchange (ETDEWEB)

Svanberg, Fredrik [Department of Environmental Toxicology, Evolutionary Biology Centre, Uppsala University, Norbyvaegen 18A, SE-752 36 Uppsala (Sweden)]. E-mail: fredriksvanberg@hotmail.com; Mateo, Rafael [Instituto de Investigacion en Recursos Cinegeticos, IREC (CSIC-UCLM-JCCM), Ronda de Toledo s/n, 13071 Ciudad Real (Spain); Hillstroem, Lars [Institute of Maths, Natural and Computer Science, University of Gaevle, SE-801 76 Gaevle (Sweden); Green, Andy J. [Wetland Ecology Group, Estacion Biologica de Donana-CSIC, Pabellon del Peru, Avenida Maria Luisa s/n, E-40013 Seville (Spain); Taggart, Mark A. [School of Biological Sciences, University of Aberdeen, Cruickshank Bld, St Machar Dr, Aberdeen, Scotland, AB24 3UU (United Kingdom); Raab, Andrea [School of Biological Sciences, University of Aberdeen, Cruickshank Bld, St Machar Dr, Aberdeen, Scotland, AB24 3UU (United Kingdom); Meharg, Andy A. [School of Biological Sciences, University of Aberdeen, Cruickshank Bld, St Machar Dr, Aberdeen, Scotland, AB24 3UU (United Kingdom)

2006-11-01

Lead isotope ratios ({sup 206}Pb/{sup 207}Pb and {sup 208}Pb/{sup 207}Pb) and concentrations in the livers and bones of marbled teal and white-headed duck found dead or moribund were determined in order to establish the main lead source in these waterfowl species. Lead concentrations in bone (dry weight) and liver (wet weight) were found to be very high in many of the white-headed ducks (bone: geometric mean = 88.9 ppm, maximum = 419 ppm; liver: geometric mean = 16.8 ppm, maximum = 57.0 ppm). Some of the marbled teal had high lead levels in the bones but liver lead levels were all low (bone: geometric mean = 6.13 ppm, maximum = 112 ppm; liver: geometric mean = 0.581 ppm, maximum = 4.77 ppm). Ingested lead shot were found in 71% of the white-headed duck and 20% of the marbled teal. The {sup 206}Pb/{sup 207}Pb ratio in livers and bones of white-headed ducks and marbled teals showed no significant differences compared to the ratios obtained from lead shot. The {sup 206}Pb/{sup 207}Pb ratio in bones of marbled teal ducklings with the highest lead concentrations tended to resemble the ratios of lead shot, which supports our hypothesis that the lead was derived from the hens. We also found that the lead ratios of lead shot and lead ratios described for soils in the area overlapped, but also that the isotopic ratio {sup 206}Pb/{sup 207}Pb in lead shot used in Spain has a narrow range compared with those used in North America. The principal source of lead in many of these birds was, however, most likely lead shot, as supported by the similar isotopic ratios, high lead concentrations in tissues and evidence of ingested shot.

The leading eikonal operator in string-brane scattering at high energy

DEFF Research Database (Denmark)

Giuseppe, D'Appollonio; di Vecchia, Paolo; Russo, Rodolfo

2015-01-01

In this paper we present two (a priori independent) derivations of the eikonal operator in string-brane scattering. The rst one is obtained by summing surfaces with any number of boundaries, while in the second one the eikonal operator is derived from the three-string vertex in a suitable light......-cone gauge. This second derivation shows that the bosonic oscillators present in the leading eikonal operator are to be identied with the string bosonic oscillators in a suitable light-cone gauge, while the rst one shows that it exponentiates recovering unitarity. This paper is a review of results obtained...

Random-field Potts model for the polar domains of lead magnesium niobate and lead scandium tantalate

Energy Technology Data Exchange (ETDEWEB)

Qian, H.; Bursill, L.A

1997-06-01

A random filed Potts model is used to establish the spatial relationship between the nanoscale distribution of charges chemical defects and nanoscale polar domains for the perovskite-based relaxor materials lead magnesium niobate (PMN) and lead scandium tantalate (PST). The random fields are not set stochastically but are determined initially by the distribution of B-site cations (Mg, Nb) or (Sc, Ta) generated by Monte Carlo NNNI-model simulations for the chemical defects. An appropriate random field Potts model is derived and algorithms developed for a 2D lattice. It is shown that the local fields are strongly correlated with the chemical domain walls and that polar domains as a function of decreasing temperature is simulated for the two cases of PMN and PST. The dynamics of the polar clusters is also discussed. 33 refs., 9 figs.

Novel series of 1,2,4-trioxane derivatives as antimalarial agents.

Science.gov (United States)

Rudrapal, Mithun; Chetia, Dipak; Singh, Vineeta

2017-12-01

Among three series of 1,2,4-trioxane derivatives, five compounds showed good in vitro antimalarial activity, three compounds of which exhibited better activity against P. falciparum resistant (RKL9) strain than the sensitive (3D7) one. Two best compounds were one from aryl series and the other from heteroaryl series with IC 50 values of 1.24 µM and 1.24 µM and 1.06 µM and 1.17 µM, against sensitive and resistant strains, respectively. Further, trioxane derivatives exhibited good binding affinity for the P. falciparum cysteine protease falcipain 2 receptor (PDB id: 3BPF) with well defined drug-like and pharmacokinetic properties based on Lipinski's rule of five with additional physicochemical and ADMET parameters. In view of having antimalarial potential, 1,2,4-trioxane derivative(s) reported herein may be useful as novel antimalarial lead(s) in the discovery and development of future antimalarial drug candidates as P. falciparum falcipain 2 inhibitors against resistant malaria.

Optimal base-stock policy for the inventory system with periodic review, backorders and sequential lead times

DEFF Research Database (Denmark)

Johansen, Søren Glud; Thorstenson, Anders

2008-01-01

We extend well-known formulae for the optimal base stock of the inventory system with continuous review and constant lead time to the case with periodic review and stochastic, sequential lead times. Our extension uses the notion of the 'extended lead time'. The derived performance measures...

Deriving GENERIC from a generalized fluctuation symmetry

NARCIS (Netherlands)

Kraaij, R.; Lazarescu, A.; Maes, C.; Peletier, M.A.

2018-01-01

Much of the structure of macroscopic evolution equations for relaxation to equilibrium can be derived from symmetries in the dynamical fluctuations around the most typical trajectory. For example, detailed balance as expressed in terms of the Lagrangian for the path-space action leads to gradient

Cumulant generating function formula of heat transfer in ballistic systems with lead-lead coupling and general nonlinear systems

Science.gov (United States)

Li, Huanan

2013-03-01

Based on a two-time observation protocol, we consider heat transfer in a given time interval tM in a lead-junction-lead system taking coupling between the leads into account. In view of the two-time observation, consistency conditions are carefully verified in our specific family of quantum histories. Furthermore, its implication is briefly explored. Then using the nonequilibrium Green's function method, we obtain an exact formula for the cumulant generating function for heat transfer between the two leads, valid in both transient and steady-state regimes. Also, a compact formula for the cumulant generating function in the long-time limit is derived, for which the Gallavotti-Cohen fluctuation symmetry is explicitly verified. In addition, we briefly discuss Di Ventra's repartitioning trick regarding whether the repartitioning procedure of the total Hamiltonian affects the nonequilibrium steady-state current fluctuation. All kinds of properties of nonequilibrium current fluctuations, such as the fluctuation theorem in different time regimes, could be readily given according to these exact formulas. Finally a practical formalism dealing with cumulants of heat transfer across general nonlinear quantum systems is established based on field theoretical/algebraic method.

Comparison of the U.S. lead recycling industry in 1998 and 2011

Science.gov (United States)

Wilburn, David R.

2014-01-01

Since 1998, the structure of the lead recycling industry has changed and trade patterns of the domestic lead recycling industry have shifted. Although the domestic demand for lead has remained relatively constant since 1998, production of lead has increasingly shifted to the domestic secondary lead industry. The last primary lead smelter in the United States closed at the end of 2013, at which time the secondary lead industry became the sole source of domestic lead production. The amount of lead recovered annually from scrap batteries generally increased from about 900,000 metric tons in 1995 to more than 1,100,000 metric tons in 2012. The percentage of total U.S. lead production attributed to battery scrap increased from 65 percent in 1995 to 87 percent in 2012. Since the North American Free Trade Agreement took effect in 1994, trade patterns among the United States, Canada, and Mexico have changed for recycled lead products. In the late 1990s, the principal sources of lead waste and scrap not derived from batteries were Canada, Mexico, and South America; by 2011, the principal sources were Central America and Asia, with decreasing amounts from Canada and South America. Since 1998, the amount of lead derived from imported batteries and scrap from Canada has ranged from 50 to 90 percent, and the amount imported from Mexico has ranged from 3 to 20 percent. Canada received about 50 percent of the lead contained in spent lead-acid batteries and scrap exported from the United States in 1998, and Mexico received about 4 percent. By 2012, however, the amount of lead scrap exported to Canada had decreased to about 10 percent, and the amount of lead-based scrap products, primarily batteries, exported to Mexico from the United States had increased to 47 percent. Vertical integration of the domestic secondary lead industry and higher costs required to implement more stringent ambient air standards in the United States have led some companies to shift lead recycling

Derivative expansion and renormalisation group flows

CERN Document Server

Litim, Daniel F

2001-01-01

We study the convergence of the derivative expansion for flow equations. The convergence strongly depends on the choice for the infrared regularisation. Based on the structure of the flow, we explain why optimised regulators lead to better physical predictions. This is applied to O(N)-symmetric real scalar field theories in 3d, where critical exponents are computed for all N. In comparison to the sharp cut-off regulator, an optimised flow improves the leading order result up to 10%. An analogous reasoning is employed for a proper time renormalisation group. We compare our results with those obtained by other methods.

Lead-isotope inhomogeneity in Precambrian igneous K-feldspars

International Nuclear Information System (INIS)

Ludwig, K.R.; Silver, L.T.

1977-01-01

Stepwise PB-removal experiments, using both vacuum volatilization and HF-leaching techniques, on acid-washed K-feldspar concentrates from Precambrian igneous rocks show that all contain some unsupported radiogenic Pb. Two types of radiogenic Pb were recognised. One has a 'normal' isotopic composition, with relative abundances of 206 Pb, 207 Pb and 208 Pb consistent with the age and U-Th contents of the rocks. The other type of unsupported radiogenic lead in the feldspars is apparently pure 206 Pb, derived from long-term migration and accumulation of radioactive daughter(s) of 238 U. This 'pure' 206 Pb lead occupies different sites from the 'normal' radiogenic lead, and tends to show a release maximum during vacuum volatilization at about 1150 0 C. The usefulness of stepwise vacuum volatilization may be limited by the tendency of a small amount of radiogenic lead to concentrate in the least volatile fraction. Stepwise partial HF attacks appear to give at least as good separation of radiogenic from original feldspar lead, and are recommended as a routine procedure for isotopic analyses of Precambrian feldspars. The fact that most of the five K-feldspars examined contained unsupported radiogenic lead implies that caution must be used in applying total-sample lead analyses of Precambrian feldspars to problems of lead-isotope evolution in crustal rocks. (author)

Carpatizine, a novel bridged oxazine derivative generated by non-enzymatic reactions.

Science.gov (United States)

Fu, Peng; MacMillan, John B

2017-06-27

Carpatizine (1), a new bridged oxazine derivative, was isolated from a marine-derived Streptomyces strain SNE-011. The structure was fully determined by spectroscopic analysis, ECD calculations and chemical methods. A plausible non-enzymatic reaction mechanism from daryamide D leading to carpatizine was presented, which was confirmed by chemical transformation.

Leading-edge flow criticality as a governing factor in leading-edge vortex initiation in unsteady airfoil flows

Science.gov (United States)

Ramesh, Kiran; Granlund, Kenneth; Ol, Michael V.; Gopalarathnam, Ashok; Edwards, Jack R.

2018-04-01

A leading-edge suction parameter (LESP) that is derived from potential flow theory as a measure of suction at the airfoil leading edge is used to study initiation of leading-edge vortex (LEV) formation in this article. The LESP hypothesis is presented, which states that LEV formation in unsteady flows for specified airfoil shape and Reynolds number occurs at a critical constant value of LESP, regardless of motion kinematics. This hypothesis is tested and validated against a large set of data from CFD and experimental studies of flows with LEV formation. The hypothesis is seen to hold except in cases with slow-rate kinematics which evince significant trailing-edge separation (which refers here to separation leading to reversed flow on the aft portion of the upper surface), thereby establishing the envelope of validity. The implication is that the critical LESP value for an airfoil-Reynolds number combination may be calibrated using CFD or experiment for just one motion and then employed to predict LEV initiation for any other (fast-rate) motion. It is also shown that the LESP concept may be used in an inverse mode to generate motion kinematics that would either prevent LEV formation or trigger the same as per aerodynamic requirements.

Next-to-next-to-leading logarithms in four-fermion electroweak processes at high energy

International Nuclear Information System (INIS)

Kuehn, J.H.; Moch, S.; Penin, A.A.; Smirnov, V.A.

2001-01-01

We sum up the next-to-next-to-leading logarithmic virtual electroweak corrections to the high energy asymptotics of the neutral current four-fermion processes for light fermions to all orders in the coupling constants using the evolution equation approach. From this all order result we derive finite order expressions through next-to-next-to leading order for the total cross section and various asymmetries. We observe an amazing cancellation between the sizable leading, next-to-leading and next-to-next-to-leading logarithmic contributions at TeV energies

The leading eikonal operator in string-brane scattering at high energy

CERN Document Server

D'Appollonio, Giuseppe; Russo, Rodolfo; Veneziano, Gabriele

2013-01-01

In this paper we present two (a priori independent) derivations of the eikonal operator in string-brane scattering. The first one is obtained by summing surfaces with any number of boundaries, while in the second one the eikonal operator is derived from the three-string vertex in a suitable light-cone gauge. This second derivation shows that the bosonic oscillators present in the leading eikonal operator are to be identified with the string bosonic oscillators in a suitable light-cone gauge, while the first one shows that it exponentiates recovering unitarity. This paper is a review of results obtained in two previous publications of the same authors.

Extraction of lead and ridge characteristics from SAR images of sea ice

Science.gov (United States)

Vesecky, John F.; Smith, Martha P.; Samadani, Ramin

1990-01-01

Image-processing techniques for extracting the characteristics of lead and pressure ridge features in SAR images of sea ice are reported. The methods are applied to a SAR image of the Beaufort Sea collected from the Seasat satellite on October 3, 1978. Estimates of lead and ridge statistics are made, e.g., lead and ridge density (number of lead or ridge pixels per unit area of image) and the distribution of lead area and orientation as well as ridge length and orientation. The information derived is useful in both ice science and polar operations for such applications as albedo and heat and momentum transfer estimates, as well as ship routing and offshore engineering.

QCD traveling waves beyond leading logarithms

International Nuclear Information System (INIS)

Peschanski, R.; Sapeta, S.

2006-01-01

We derive the asymptotic traveling-wave solutions of the nonlinear 1-dimensional Balitsky-Kovchegov QCD equation for rapidity evolution in momentum space, with 1-loop running coupling constant and equipped with the Balitsky-Kovchegov-Kuraev-Lipatov kernel at next-to-leading logarithmic accuracy, conveniently regularized by different resummation schemes. Traveling waves allow us to define ''universality classes'' of asymptotic solutions, i.e. independent of initial conditions and of the nonlinear damping. A dependence on the resummation scheme remains, which is analyzed in terms of geometric scaling properties

Stable lead geochronology of fine-grained sediments in Southern Lake Michigan

International Nuclear Information System (INIS)

Robbins, J.A.; Edgington, D.N.

1974-01-01

In a previous article, it was shown that the vertical distribution of stable lead in the fine-grained sediments of Lake Michigan reflects the history of cultural lead inputs. It was found that the lead distributions in dated cores are quantitatively described by a universal time-dependent loading or source function which is a linear combination of estimated annual inputs of atmospheric lead derived from the combustion of leaded gasoline and the burning of coal in and around Chicago since about 1800. The existence of such a source function for lead implies that stable lead itself may be used to date sediment cores. Mercury depth profiles in western Lake Erie sediments have shown several horizons which correspond to the development of local industrial use of mercury over the past forty years or so. The construction of the lead source function for Lake Michigan sediments was based on only four lead-210 dated cores. To establish the validity of the source function concept, it is applied to the distribution of lead determined in many cores previously obtained from southern Lake Michigan

The covariance matrix of derived quantities and their combination

International Nuclear Information System (INIS)

Zhao, Z.; Perey, F.G.

1992-06-01

The covariance matrix of quantities derived from measured data via nonlinear relations are only approximate since they are functions of the measured data taken as estimates for the true values of the measured quantities. The evaluation of such derived quantities entails new estimates for the true values of the measured quantities and consequently implies a modification of the covariance matrix of the derived quantities that was used in the evaluation process. Failure to recognize such an implication can lead to inconsistencies between the results of different evaluation strategies. In this report we show that an iterative procedure can eliminate such inconsistencies

The stratigraphy of the Malmani dolomite subgroup in the Carletonville area, Transvaal: genetic implications for lead-zinc mineralization

International Nuclear Information System (INIS)

Clay, A.N.

1986-01-01

The geological setting of a borehole intersection of lead-zinc mineralization in the Malmani Dolomite Subgroup in the Carletonville area is discussed. It is suggested that the lead and zinc ions were derived from the overlying shales, transported as bisulphide complexes in silica-enriched, alkaline solutions, and deposited during silicification in the upper part of the dolomite succession which contains relic evaporites. Lead isotope data suggests that the known lead-zinc deposits in the Transvaal sequence are not of major importance. However, the dolomites are regarded as very probable hosts for Mississippi Valley type base metal deposits and offer important exploration targets. This study includes lead isotopic data. Lead isotope compositions and model lead ages for galenas in the zinc deposits are shown. It is concluded that the leads have undergone either a two-stage evolution process, or have mixed with 206 Pb-enriched ores. Model ages suggest that the lead was derived from an approximate 2,7 Ga source and that mineralization took place at 1,7 Ga

Lead exposure in radiator repair workers: a survey of Washington State radiator repair shops and review of occupational lead exposure registry data.

Science.gov (United States)

Whittaker, Stephen G

2003-07-01

Radiator repair workers in Washington State have the greatest number of very elevated (> or =60 microg/dL) blood lead levels of any other worker population. The goals of this study were to determine the number of radiator repair workers potentially exposed to lead; estimate the extent of blood lead data underreporting to the Occupational Lead Exposure Registry; describe current safety and health practices in radiator repair shops; and determine appropriate intervention strategies to reduce exposure and increase employer and worker awareness. Lead exposure in Washington State's radiator repair workers was assessed by reviewing Registry data and conducting a statewide survey of radiator repair businesses. This study revealed that a total of 226 workers in Washington State (including owner-operators and all employees) conduct repair activities that could potentially result in excessive exposures to lead. Approximately 26% of radiator repair workers with elevated blood lead levels (> or =25 microg/dL) were determined to report to Washington State's Registry. This study also revealed a lack of awareness of lead's health effects, appropriate industrial hygiene controls, and the requirements of the Lead Standard. Survey respondents requested information on a variety of workplace health and safety issues and waste management; 80% requested a confidential, free-of-charge consultation. Combining data derived from an occupational health surveillance system and a statewide mail survey proved effective at characterizing lead exposures and directing public health intervention in Washington State.

A combined method to estimate the appropriate age value of closed uraniun-lead system

International Nuclear Information System (INIS)

Malakhov, S.S.

1982-01-01

A new method is proposed for obtaining the appropriate age values of closed uranium-lead systems taking into account total indeependent information delivered as a result of spectral and isotope-lead analyses. A simple mathematical apparatus which permits to perform a geochronological interpretation of samples using miniature computers is considered and suggested. A simple estimation formula for determining the age of uranium-lead systems under the assumption of model development of isotope ratios of ordinary lead is derived and tested basing on the facts

Stability of racemic and chiral steady states in open and closed chemical systems

Energy Technology Data Exchange (ETDEWEB)

Ribo, Josep M. [Departament de Quimica Organica, Universitat de Barcelona, c. Marti i Franques 1, Barcelona (Spain); Hochberg, David [Centro de Astrobiologia (CSIC-INTA), Ctra. Ajalvir Km. 4, 28850 Torrejon de Ardoz, Madrid (Spain)], E-mail: hochbergd@inta.es

2008-12-22

The stability properties of models of spontaneous mirror symmetry breaking in chemistry are characterized algebraically. The models considered here all derive either from the Frank model or from autocatalysis with limited enantioselectivity. Emphasis is given to identifying the critical parameter controlling the chiral symmetry breaking transition from racemic to chiral steady-state solutions. This parameter is identified in each case, and the constraints on the chemical rate constants determined from dynamic stability are derived.

Stability of racemic and chiral steady states in open and closed chemical systems

International Nuclear Information System (INIS)

Ribo, Josep M.; Hochberg, David

2008-01-01

The stability properties of models of spontaneous mirror symmetry breaking in chemistry are characterized algebraically. The models considered here all derive either from the Frank model or from autocatalysis with limited enantioselectivity. Emphasis is given to identifying the critical parameter controlling the chiral symmetry breaking transition from racemic to chiral steady-state solutions. This parameter is identified in each case, and the constraints on the chemical rate constants determined from dynamic stability are derived

An optimized lead system for long-term esophageal electrocardiography

International Nuclear Information System (INIS)

Niederhauser, T; Haeberlin, A; Vogel, R; Marisa, T; Goette, J; Jacomet, M; Mattle, D; Abächerli, R

2014-01-01

Long-term electrocardiography (ECG) featuring adequate atrial and ventricular signal quality is highly desirable. Routinely used surface leads are limited in atrial signal sensitivity and recording capability impeding complete ECG delineation, i.e. in the presence of supraventricular arrhythmias. Long-term esophageal ECG might overcome these limitations but requires a dedicated lead system and recorder design. To this end, we analysed multiple-lead esophageal ECGs with respect to signal quality by describing the ECG waves as a function of the insertion level, interelectrode distance, electrode shape and amplifier's input range. The results derived from clinical data show that two bipolar esophageal leads, an atrial lead with short (15 mm) interelectrode distance and a ventricular lead with long (80 mm) interelectrode distance provide non-inferior ventricular signal strength and superior atrial signal strength compared to standard surface lead II. High atrial signal slope in particular is observed with the atrial esophageal lead. The proposed esophageal lead system in combination with an increased recorder input range of ±20 mV minimizes signal loss due to excessive electrode motion typically observed in esophageal ECGs. The design proposal might help to standardize long-term esophageal ECG registrations and facilitate novel ECG classification systems based on the independent detection of ventricular and atrial electrical activity. (paper)

Animals afflicted with lead poisoning from motor exhaust

Energy Technology Data Exchange (ETDEWEB)

Scheel-Thomsen, A

1956-01-01

Three cases of dogs treated for ulcerous conditions of the oral cavity and a trembling of the limbs, which were eventually discovered to be lead poisoning derived from constant exposure to gasoline and automotive exhaust, are reported. The first case, typical of all three, was first treated in April 1951. The lesions healed after a stay in the hospital but recurred after he returned home. The dog was also asymptomatic when at the owner's summer home for any length of time. It was discovered that at his winter home the dog spent much of his time around a large automobile garage. After treatment with Antoxol (dimercaprol) and benzyl benzoate, he recovered and had no more symptoms of lead poisoning until his death from cancer several years later. Each of the three involved an animal whose daily activities exposed him to the continual presence of gasolines and exhaust fumes containing tetraethyl lead.

Leading-order classical Lagrangians for the nonminimal standard-model extension

Science.gov (United States)

Reis, J. A. A. S.; Schreck, M.

2018-03-01

In this paper, we derive the general leading-order classical Lagrangian covering all fermion operators of the nonminimal standard-model extension (SME). Such a Lagrangian is considered to be the point-particle analog of the effective field theory description of Lorentz violation that is provided by the SME. At leading order in Lorentz violation, the Lagrangian obtained satisfies the set of five nonlinear equations that govern the map from the field theory to the classical description. This result can be of use for phenomenological studies of classical bodies in gravitational fields.

Studies in higher-derivative gravitation

International Nuclear Information System (INIS)

Dutt, S.K.

1987-01-01

In this work two formulations of gravitation in which the action includes the second-derivatives of the metric in a non-trivial fashion are investigated. In the first part, the gauge theory of gravitation proposed by Yang in 1974 is investigated. The implications of coupling the pure space equations to matter sources via the action principle proposed by Yang is studied. It is shown that this action principle does not couple to matter sources in a satisfactory fashion. An earlier study by Fairchild along similar lines is critically examined. It is argued that Fairchild's action functional, and his objections to Yang's gauge approach to gravitation, arise from a not very meaningful analogy with the case of a general gauge field. Also, a conjecture originated in that work is refuted. A modification of Yang's action functional is provided which leads to both the Einstein and Yang field-equations. This system is shown to have non-trivial solutions in the presence of matter. An additional advantage is that the unphysical solutions of the pure space equations can be ruled out. It is shown that the joint system of Einstein and Yang field-equations leads to a physically viable cosmological model based on the Robertson-Walker metric, which satisfies both sets of field-equations. In the second part of this work, the Hamiltonian for pure gravity in Einstein's theory is obtained directly from the Hilbert Lagrangian. Since the Lagrangian depends upon the second-derivatives of the metric tensor, first the Hamiltonian formulation for a Lagrangian which may, in general depend upon the Nth-order time derivatives of the dynamical variables is developed

Constructive definition of functional derivatives in density-functional theory

International Nuclear Information System (INIS)

Luo Ji

2006-01-01

It is shown that the functional derivatives in density-functional theory (DFT) can be explicitly defined within the domain of electron densities restricted by the electron number, and a constructive definition of such restricted derivatives is suggested. With this definition, Kohn-Sham (KS) equations can be established for an N-electron system without extending the functional domain and introducing a Lagrange multiplier. This may clarify some of the fundamental questions raised by Nesbet (1998 Phys. Rev. A 58 R12). The definition naturally leads to the fact that the KS effective potential is determined only to within an additive constant, thus the KS levels can shift freely and the relation between the highest occupied molecular orbital (HOMO) energy and the ionization potential of the system depends on the choice of the constant. On the other hand, if the domain of functionals is indeed extended beyond the electron number restriction, conclusions depend on whether the extended functionals have unrestricted derivatives or not. It is shown that the ensemble extension of DFT to open systems of mixed states (Perdew et al 1982 Phys. Rev. Lett. 49 1691) leads to an energy functional which has no unrestricted derivative at integer electron numbers. Hence after this extension, the relation between the HOMO energy and the ionization potential for an N-electron system is still uncertain. Besides, there are different extensions of the energy functional to a domain of densities unrestricted by the integer electron number, resulting in different unrestricted derivatives and electron systems with different chemical potentials. Even for the exact exchange-correlation potential, there is still an undetermined constant, whether it is a restricted or unrestricted derivative

Effects of stacking fault energies on the interaction between an edge dislocation and an 8.0-nm-diameter Frank loop of self-interstitial atoms

Directory of Open Access Journals (Sweden)

S. Hayakawa

2016-12-01

Full Text Available Molecular dynamics simulations were conducted to investigate the effects of stacking fault energy (SFE as a single variable parameter on the interaction between an edge dislocation and a Frank loop of self-interstitial atoms with a diameter of 8.0nm. The physical contact between the edge dislocation and the loop causes constriction of the edge dislocation, followed by the formation of a D-Shockley partial dislocation. The latter process is associated with either the formation of a screw component and its cross-slip, or the direct core reaction between the dislocation and the loop. These processes induce either the absorption of the loop into the dislocation or the transformation of the loop into a perfect loop. The SFE influences the interaction morphologies by determining the separation distance of the two partial dislocations and consequently the rate of constriction. The dependence of the interaction morphology on the SFE varies with the habit plane of the loop. A higher SFE increases the probability of the absorption or transformation interaction; however, only loop shearing is observed at the lower limit of the SFE range of austenitic stainless steels.

Relative contributions of energy expenditure on physical activity, body composition and weight gain to the evolution of impaired glucose to tolerance to Frank diabetes

International Nuclear Information System (INIS)

Forrester, T.; Wilks, R.; Gaskin, P.; Luke, A.; Jahoor, F.; Adeyemo, A.

2002-01-01

There is a gradient of diabetes prevalence among populations of the African Diaspora, with a rate of about 1% in West Africa, 12% in Jamaica and 16% in the United States. A population-based survey was conducted in an urban community in Jamaica to document the risk factors for the evolution of impaired glucose tolerance to frank diabetes. In a sample of 614 adults, 239 men and 375 women, oral glucose tolerance tests and examinations were conducted at Baseline and after 4-years of Follow-Up. There were significant increases in virtually all weight and adiposity variables for both men and women. Energy expenditure was also measured in a subset of participants at Follow-Up and was related significantly to glucose tolerance status. Among men, baseline age, weight, fat mass, body fat, waist circumference, and change in waist circumference were predictive of worsening glucose tolerance status. Among women, only age and change in waist circumference was a significant predictor. No physical activity parameter was predictive of change in tolerance status. These results provide support for the need to decrease adiposity as an important mechanism to control the rise in diabetes prevalence. (author)

Antiviral lead compounds from marine sponges

KAUST Repository

Sagar, Sunil

2010-10-11

Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. They are usually produced by functional enzyme clusters in sponges and/or their associated symbiotic microorganisms. Natural product lead compounds from sponges have often been found to be promising pharmaceutical agents. Several of them have successfully been approved as antiviral agents for clinical use or have been advanced to the late stages of clinical trials. Most of these drugs are used for the treatment of human immunodeficiency virus (HIV) and herpes simplex virus (HSV). The most important antiviral lead of marine origin reported thus far is nucleoside Ara-A (vidarabine) isolated from sponge Tethya crypta. It inhibits viral DNA polymerase and DNA synthesis of herpes, vaccinica and varicella zoster viruses. However due to the discovery of new types of viruses and emergence of drug resistant strains, it is necessary to develop new antiviral lead compounds continuously. Several sponge derived antiviral lead compounds which are hopedto be developed as future drugs are discussed in this review. Supply problems are usually the major bottleneck to the development of these compounds as drugs during clinical trials. However advances in the field of metagenomics and high throughput microbial cultivation has raised the possibility that these techniques could lead to the cost-effective large scale production of such compounds. Perspectives on biotechnological methods with respect to marine drug development are also discussed. 2010 by the authors; licensee MDPI.

Unsaturated Fatty Acids Supplementation Reduces Blood Lead Level in Rats

Science.gov (United States)

Skoczyńska, Anna; Wojakowska, Anna; Nowacki, Dorian; Bobak, Łukasz; Turczyn, Barbara; Smyk, Beata; Szuba, Andrzej; Trziszka, Tadeusz

2015-01-01

Some dietary factors could inhibit lead toxicity. The aim of this study was to evaluate the effect of dietary compounds rich in unsaturated fatty acids (FA) on blood lead level, lipid metabolism, and vascular reactivity in rats. Serum metallothionein and organs' lead level were evaluated with the aim of assessing the possible mechanism of unsaturated FA impact on blood lead level. For three months, male Wistar rats that were receiving drinking water with (100 ppm Pb) or without lead acetate were supplemented per os daily with virgin olive oil or linseed oil (0.2 mL/kg b.w.) or egg derived lecithin fraction: “super lecithin” (50 g/kg b.w.). Mesenteric artery was stimulated ex vivo by norepinephrine (NE) administered at six different doses. Lecithin supplementation slightly reduced pressor responses of artery to NE. Lead administered to rats attenuated the beneficial effect of unsaturated FA on lipid metabolism and vascular reactivity to adrenergic stimulation. On the other hand, the super lecithin and linseed oil that were characterized by low omega-6 to omega-3 ratio (about 1) reduced the blood lead concentration. This effect was observed in lead poisoned rats (p < 0.0001) and also in rats nonpoisoned with lead (p < 0.05). PMID:26075218

Contaminated lead environments of man: reviewing the lead isotopic evidence in sediments, peat, and soils for the temporal and spatial patterns of atmospheric lead pollution in Sweden.

Science.gov (United States)

Bindler, Richard

2011-08-01

Clair Patterson and colleagues demonstrated already four decades ago that the lead cycle was greatly altered on a global scale by humans. Moreover, this change occurred long before the implementation of monitoring programs designed to study lead and other trace metals. Patterson and colleagues also developed stable lead isotope analyses as a tool to differentiate between natural and pollution-derived lead. Since then, stable isotope analyses of sediment, peat, herbaria collections, soils, and forest plants have given us new insights into lead biogeochemical cycling in space and time. Three important conclusions from our studies of lead in the Swedish environment conducted over the past 15 years, which are well supported by extensive results from elsewhere in Europe and in North America, are: (1) lead deposition rates at sites removed from major point sources during the twentieth century were about 1,000 times higher than natural background deposition rates a few thousand years ago (~10 mg Pb m(-2) year(-1) vs. 0.01 mg Pb m(-2) year(-1)), and even today (~1 mg Pb m(-2) year(-1)) are still almost 100 times greater than natural rates. This increase from natural background to maximum fluxes is similar to estimated changes in body burdens of lead from ancient times to the twentieth century. (2) Stable lead isotopes ((206)Pb/(207)Pb ratios shown in this paper) are an effective tool to distinguish anthropogenic lead from the natural lead present in sediments, peat, and soils for both the majority of sites receiving diffuse inputs from long range and regional sources and for sites in close proximity to point sources. In sediments >3,500 years and in the parent soil material of the C-horizon, (206)Pb/(207)Pb ratios are higher, 1.3 to >2.0, whereas pollution sources and surface soils and peat have lower ratios that have been in the range 1.14-1.18. (3) Using stable lead isotopes, we have estimated that in southern Sweden the cumulative anthropogenic burden of

Best Practice Guide on the Control of Lead in Drinking Water

Science.gov (United States)

This book is a critical synthesis of international experiences with the control of lead in drinking water, derived from the European research network COST Action 637, supported by a wide range of experts from 26 European countries, the United States, and Canada. The book covers ...

Contradiction and Conflict between "Leading Identities": Becoming an Engineer versus Becoming a "Good Muslim" Woman

Science.gov (United States)

Black, Laura; Williams, Julian

2013-01-01

This paper builds on previous work (Black et al., "Educational Studies in Mathematics" 73(1):55-72, 2010) which developed the notion of a "leading identity" (derived from Leont'ev's concept of "leading activity") which, we argued, defined students' motive for studying during late adolescence. We…

Food-derived bioactive peptides on inflammation and oxidative stress.

Science.gov (United States)

Chakrabarti, Subhadeep; Jahandideh, Forough; Wu, Jianping

2014-01-01

Chronic diseases such as atherosclerosis and cancer are now the leading causes of morbidity and mortality worldwide. Inflammatory processes and oxidative stress underlie the pathogenesis of these pathological conditions. Bioactive peptides derived from food proteins have been evaluated for various beneficial effects, including anti-inflammatory and antioxidant properties. In this review, we summarize the roles of various food-derived bioactive peptides in inflammation and oxidative stress and discuss the potential benefits and limitations of using these compounds against the burden of chronic diseases.

Ore lead isotope ratios in a continually changing Earth

International Nuclear Information System (INIS)

Cumming, G.L.; Richards, J.R.

1975-01-01

A critical reassessment of the construction of simple ore lead isotopic development curves is followed by three fresh approximations, all designed to involve the minimum possible number of assumptions. All are based on the Russell-Reynolds algorithm, when in its simplest form involves knowledge only of ratios, not of ages. The calculations are applied to a restricted class of ore leads, and the latest constant values for the U and Th isotopes are employed. Model I treats all data as being of equal weight, and shows that the deletion or inclusion of the Canyon Diablo meterorite data makes no difference to the derived parameters. Model II demonstrates that essentially the same parameters result if the simple curve is forced through the meteorite point; i.e. questions about homogeneity or otherwise of 'initial terrestrial'Pb are unimportant to the regression . Model III makes allowance for the known discrepancy in young 'model ages' by providing for a steady linear change in U/Pb and Th/Pb. The additional assumption of one fixed time point proves necessary. An age close to 430 m.y.for Captains Flat, N.S.W., yields acceptable age estimates for most other deposits investigated. No claim is made for the uniquences of this solution, but the derived evidence for steady growth in U/Ph accompanied by a slight decline in Th/U seems compatible with a crustal source for the lead ores concerned. (Auth.)

Inventory control in multi-echelon divergent systems with random lead times

NARCIS (Netherlands)

Heijden, van der M.C.; Diks, E.B.; Kok, de A.G.

1996-01-01

This paper deals with integral inventory control in multi-echelon divergent systems with stochastic lead times. The policy considered is an echelon stock, periodic review, order-up-to (R, S) policy. A computational method is derived to obtain the order-up-to level and the allocation fractions

Inventory control in multi-echelon divergent systems with random lead times

NARCIS (Netherlands)

van der Heijden, Matthijs C.; Diks, Erik; de Kok, Ton

1999-01-01

This paper deals with integral inventory control in multi-echelon divergent systems with stochastic lead times. The policy considered is an echelon stock, periodic review, order-up-to (R, S) policy. A computational method is derived to obtain the order-up-to level and the allocation fractions

Design of an Actinide Burning, Lead or Lead-Bismuth Cooled Reactor that Produces Low Cost Electricity FY-01 Annual Report, October 2001

Energy Technology Data Exchange (ETDEWEB)

Mac Donald, Philip Elsworth; Buongiorno, Jacopo; Davis, Cliff Bybee; Herring, James Stephen; Loewen, Eric Paul; Smolik, Galen Richard; Weaver, Kevan Dean; Todreas, N.

2001-10-01

The purpose of this collaborative Idaho National Engineering and Environmental Laboratory (INEEL) and Massachusetts Institute of Technology (MIT) Laboratory Directed Research and Development (LDRD) project is to investigate the suitability of lead or lead-bismuth cooled fast reactors for producing low-cost electricity as well as for actinide burning. The goal is to identify and analyze the key technical issues in core neutronics, materials, thermal-hydraulics, fuels, and economics associated with the development of this reactor concept. Work has been accomplished in four major areas of research: core neutronic design, plant engineering, material compatibility studies, and coolant activation. The publications derived from work on this project (since project inception) are listed in Appendix A.

Impact on the environment from steel bridge paint deterioration using lead isotopic tracing, paint compositions and soil deconstruction

Energy Technology Data Exchange (ETDEWEB)

Gulson, Brian, E-mail: brian.gulson@mq.edu.au [Department of Environmental Science, Macquarie University, Sydney, NSW 2109 (Australia); CSIRO Energy Flagship, North Ryde, NSW 2113 (Australia); Chiaradia, Massimo [Department of Mineralogy, University of Geneva, Geneva (Switzerland); Davis, Jeffrey [CSIRO Energy Flagship, North Ryde, NSW 2113 (Australia); O' Connor, Gary [Queensland Department of Environment & Heritage Protection, Brisbane, QLD 4000 (Australia)

2016-04-15

Deterioration and repair of lead paint on steel structures can result in contamination of the ambient environment but other sources of lead such as from past use of leaded paint and gasoline and industrial activities can also contribute to the contamination. Using a combination of high precision lead isotopic tracing, detailed paint examination, including with scanning electron microscopy, and soil deconstruction we have compared paint on a steel bridge and bulk soil and lead-rich particles separated from soil. The majority of Pb found in the paint derives from Australian sources but some also has a probable US origin. The isotopic data for the bulk soils and selected particles lie on a mixing line with end members the geologically ancient Broken Hill lead and possible European lead which is suggested to be derived from old lead paint and industrial activities. Data for gasoline-derived particulates lie on this array and probably contribute to soil Pb. Although paint from the bridge can be a source of lead in the soils, isotopic tracing, paint morphology and mineralogical identification indicate that other sources, including from paint, gasoline and industrial activities, are contributing factors to the lead burden. Even though physical characteristics and elemental composition are the same in some particles, the isotopic signatures demonstrate that the sources are different. Plots using {sup 206}Pb/{sup 208}Pb vs {sup 206}Pb/{sup 207}Pb ratios, the common representation these days, do not allow for source discrimination in this investigation. - Highlights: • Soil Pb values up to 1200 mg/kg below Pb painted bridge • Microscopy & SEM characterised up to 6 different paint layers. • Isotopes identified different sources of Pb including paint and gasoline. • Multiple methods provide definitive answers.

Properties of three-body decay functions derived with time-like jet calculus beyond leading order

International Nuclear Information System (INIS)

Sugiura, Tetsuya

2002-01-01

Three-body decay functions in time-like parton branching are calculated using the jet calculus to the next-to-leading logarithmic (NLL) order in perturbative quantum chromodynamics (QCD). The phase space contributions from each of the ladder diagrams and interference diagrams are presented. We correct part of the results for the three-body decay functions calculated previously by two groups. Employing our new results, the properties of the three-body decay functions in the regions of soft partons are examined numerically. Furthermore, we examine the contribution of the three-body decay functions modified by the restriction resulting from the kinematical boundary of the phase space for two-body decay in the parton shower model. This restriction leads to some problems for the parton shower model. For this reason, we propose a new restriction introduced by the kinematical boundary of the phase space for two-body decay. (author)

In vivo x-ray fluorescence of bone lead in the study of human lead metabolism: Serum lead, whole blood lead, bone lead, and cumulative exposure

International Nuclear Information System (INIS)

Cake, K.M.; Chettle, D.R.; Webber, C.E.; Gordon, C.L.

1995-01-01

Traditionally, clinical studies of lead's effect on health have relied on blood lead levels to indicate lead exposure. However, this is unsatisfactory because blood lead levels have a half-life of approximately 5 weeks, and thus reflect recent exposure. Over 90% of the lead body burden is in bone, and it is thought to have a long residence time, thus implying that measurements of bone lead reflect cumulative exposure. So, measurements of bone lead are useful in understanding the long-term health effects of lead. Ahlgren reported the first noninvasive measurements of bone lead in humans, where γ-rays from 57 Co were used to excite the K series x-rays of lead. The lead detection system at McMaster University uses a 109 Cd source which is positioned at the center of the detector face (HPGe) and a near backscatter (∼160 degrees) geometry. This arrangement allows great flexibility, since one can sample lead in a range of different bone sites due to a robust normalization technique which eliminates the need to correct for bone geometry, thickness of overlying tissue, and other related factors. The effective radiation dose to an adult during an x-ray fluorescence bone lead measurement is extremely low, being 35 nSv. This paper addresses the issue of how bone, whole blood, and serum lead concentrations can be related in order to understand a person's lead exposure history

Synthesis and biological evaluation of arctigenin ester and ether derivatives as activators of AMPK.

Science.gov (United States)

Shen, Sida; Zhuang, Jingjing; Chen, Yijia; Lei, Min; Chen, Jing; Shen, Xu; Hu, Lihong

2013-07-01

A series of new arctigenin and 9-deoxy-arctigenin derivatives bearing different ester and ether side chains at the phenolic hydroxyl positions are designed, synthesized, and evaluated for activating AMPK potency in L6 myoblasts. Initial biological evaluation indicates that some alkyl ester and phenethyl ether arctigenin derivatives display potential activities in AMPK phosphorylation improvement. Further structure-activity relationship analysis shows that arctigenin ester derivatives 3a, 3h and 9-deoxy-arctigenin phenethyl ether derivatives 6a, 6c, 6d activate AMPK more potently than arctigenin. Moreover, the 2-(3,4-dimethoxyphenyl)ethyl ether moiety of 6c has been demonstrated as a potential functional group to improve the effect of AMPK phosphorylation. The structural optimization of arctigenin leads to the identification of 6c as a promising lead compound that exhibits excellent activity in AMPK activation. Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.

Leading order finite size effects with spins for inspiralling compact binaries

Energy Technology Data Exchange (ETDEWEB)

Levi, Michele [Université Pierre et Marie Curie-Paris VI, CNRS-UMR 7095, Institut d’Astrophysique de Paris, 98 bis Boulevard Arago, 75014 Paris (France); Sorbonne Universités, Institut Lagrange de Paris, 98 bis Boulevard Arago, 75014 Paris (France); Steinhoff, Jan [Max-Planck-Institute for Gravitational Physics - Albert-Einstein-Institute,Am Mühlenberg 1, 14476 Potsdam-Golm (Germany); Centro Multidisciplinar de Astrofisica, Instituto Superior Tecnico, Universidade de Lisboa,Avenida Rovisco Pais 1, 1049-001 Lisboa (Portugal)

2015-06-10

The leading order finite size effects due to spin, namely that of the cubic and quartic in spin interactions, are derived for the first time for generic compact binaries via the effective field theory for gravitating spinning objects. These corrections enter at the third and a half and fourth post-Newtonian orders, respectively, for rapidly rotating compact objects. Hence, we complete the leading order finite size effects with spin up to the fourth post-Newtonian accuracy. We arrive at this by augmenting the point particle effective action with new higher dimensional nonminimal coupling worldline operators, involving higher-order derivatives of the gravitational field, and introducing new Wilson coefficients, corresponding to constants, which describe the octupole and hexadecapole deformations of the object due to spin. These Wilson coefficients are fixed to unity in the black hole case. The nonminimal coupling worldline operators enter the action with the electric and magnetic components of the Weyl tensor of even and odd parity, coupled to even and odd worldline spin tensors, respectively. Moreover, the non relativistic gravitational field decomposition, which we employ, demonstrates a coupling hierarchy of the gravito-magnetic vector and the Newtonian scalar, to the odd and even in spin operators, respectively, which extends that of minimal coupling. This observation is useful for the construction of the Feynman diagrams, and provides an instructive analogy between the leading order spin-orbit and cubic in spin interactions, and between the leading order quadratic and quartic in spin interactions.

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development.

Directory of Open Access Journals (Sweden)

Ville Härmä

Full Text Available The anti-invasive and anti-proliferative effects of betulins and abietane derivatives was systematically tested using an organotypic model system of advanced, castration-resistant prostate cancers. A preliminary screen of the initial set of 93 compounds was performed in two-dimensional (2D growth conditions using non-transformed prostate epithelial cells (EP156T, an androgen-sensitive prostate cancer cell line (LNCaP, and the castration-resistant, highly invasive cell line PC-3. The 25 most promising compounds were all betulin derivatives. These were selected for a focused secondary screen in three-dimensional (3D growth conditions, with the goal to identify the most effective and specific anti-invasive compounds. Additional sensitivity and cytotoxicity tests were then performed using an extended cell line panel. The effects of these compounds on cell cycle progression, mitosis, proliferation and unspecific cytotoxicity, versus their ability to specifically interfere with cell motility and tumor cell invasion was addressed. To identify potential mechanisms of action and likely compound targets, multiplex profiling of compound effects on a panel of 43 human protein kinases was performed. These target de-convolution studies, combined with the phenotypic analyses of multicellular organoids in 3D models, revealed specific inhibition of AKT signaling linked to effects on the organization of the actin cytoskeleton as the most likely driver of altered cell morphology and motility.

The economic consequences of elevated body-lead burdens in urban children

International Nuclear Information System (INIS)

Agree, M.D.

1991-01-01

The following analysis develops the theory and implementation of the observed behavior technique in an altruistic setting, to assess the health benefits of reducing environmental lead exposure in urban children. Three models are presented which allow for endogenous body lead burden, risk of irreversible neurological damages, and Bayesian information. Conditions are derived under which the observed behavior technique can be modified to value the health consequences of exposure to a general class of persistent micropollutants (PMP's): the heavy metals. Benefit expressions reflect the tradeoff between parental wealth and child health when children are exposed to low level doses of lead. The purpose is to derive exact measures of marginal welfare change associated with variations in child body lead burden, and to determine the conditions under which these measures will be functions of observable parameters. The analysis presents an entirely ex ante approach to the recovery of benefit estimates when PMP exposure involves risk of irreversible health damages. In doing so, an empirical estimate is also obtained for the parental value of child health information that is used in the revision of prior risk beliefs. Risk of chronic irreversible health effects in younger generations from environmental lead exposure may be experienced by a large share of metropolitan population in the US. Given the large numbers of possible victims, the aggregate social value of avoiding this risk is an important policy issues. Moreover, the value of health risk information is potentially important to the use of an information program as a policy instrument in reducing health risk because it would enable the comparison of societal benefits from an information program to the cost of it's implementation

Synthesis and antimalarial evaluation of novel isocryptolepine derivatives.

Science.gov (United States)

Whittell, Louise R; Batty, Kevin T; Wong, Rina P M; Bolitho, Erin M; Fox, Simon A; Davis, Timothy M E; Murray, Paul E

2011-12-15

A series of mono- and di-substituted analogues of isocryptolepine have been synthesized and evaluated for in vitro antimalarial activity against chloroquine sensitive (3D7) and resistant (W2mef) Plasmodium falciparum and for cytotoxicity (3T3 cells). Di-halogenated compounds were the most potent derivatives and 8-bromo-2-chloroisocryptolepine displayed the highest selectivity index (106; the ratio of cytotoxicity (IC(50)=9005 nM) to antimalarial activity (IC(50)=85 nM)). Our evaluation of novel isocryptolepine compounds has demonstrated that di-halogenated derivatives are promising antimalarial lead compounds. Copyright © 2011 Elsevier Ltd. All rights reserved.

Effect of low blood lead levels on anaemia indicators and creatinine clearance rate of workers occupationally exposed to lead

International Nuclear Information System (INIS)

Memon, F.; Vasandani, A.G.M.

2009-01-01

Although recognized and written about centuries, lead toxicity remains an occupational and public health problem of global dimensions. Several studies have demonstrated that clinical and sub clinical effects of lead toxicity at the blood lead levels considered as safe, i.e., below 30 mug/dl in adults and 10 mu g/dl in children. Such studies have received scant attention in the case of lead occupational workers due to the presumption of high blood lead levels in accordance with occupation. In the present study, therefore an attempt was made to investigate the effect of low blood lead levels on indicators of anaemia and renal impairment. A cohort of 690 subjects who had been occupationally exposed to lead was studied using stratified random sampling design. The markers of anaemia included changes in Haematocrit value, Haemoglobin and Erythrocyte count where as renal health was judged from changes in creatinine clearance rate. The controls were derived from similar socioeconomic background and matched in age and sex with subjects. Blood lead levels were determined by graphite furnace atomic absorption and biochemical determinations carried out using standard procedures. Blood lead levels in the range 10-40 mu g/dl had significant effect on anaemia indicators and resulted in inverse co relationship. (Pearson's correlation coefficient r-0.65, -0.71 and -0.58 respectively for haematocrit, erythrocyte count and haemoglobin). The creatinine clearance rate estimated after adjustment for body mass index and age factors was found to depend on blood lead level and duration of exposure of subjects. These effects were statistically significant in the subjects having age in the range 15-30 years. Low lead levels in blood have high potential of inducing lead related anaemia by disturbing the pathway of heme synthesis at either ferrochetalase stage or inhibiting the amino levulinate dehydratase activity. Though creatinine clearance rate did not prove as reliable marker of renal

Discovering novel plant-derived drug leads for the treatment of HIV through an integrated approach

CSIR Research Space (South Africa)

Nthambeleni, R

2010-09-01

Full Text Available HIV/AIDS is now the leading cause of death in Sub-Saharan Africa and has moved up to fourth place among all causes of death worldwide. According to estimates from the UNAIDS 2009 report (UNAIDS 2009) on the global AIDS epidemic, around 33.4 million...

Higher covariant derivative Pauli-Villars regularization does not lead to a consistent QCD

Energy Technology Data Exchange (ETDEWEB)

Martin, C P [Universidad Autonoma de Madrid (Spain). Dept. de Fisica Teorica; Ruiz Ruiz, F [Nationaal Inst. voor Kernfysica en Hoge-Energiefysica (NIKHEF), Amsterdam (Netherlands). Sectie H

1994-12-31

We compute the beta function at one loop for Yang-Mills theory using as regulator the combination of higher covariant derivatives and Pauli-Villars determinants proposed by Faddeev and Slavnov. This regularization prescription has the appealing feature that it is manifestly gauge invariant and essentially four-dimensional. It happens however that the one-loop coefficient in the beta function that it yields is not -11/3, as it should be, but -23/6. The difference is due to unphysical logarithmic radiative corrections generated by the Pauli-Villars determinants on which the regularization method is based. This no-go result discards the prescription as a viable gauge invariant regularization, thus solving a long-standing open question in the literature. We also observe that the precsription can be modified so as to not generate unphysical logarithmic corrections, but at the expense of losing manifest gauge invariance. (orig.).

Higher covariant derivative Pauli-Villars regularization does not lead to a consistent QCD

International Nuclear Information System (INIS)

Martin, C.P.; Ruiz Ruiz, F.

1994-01-01

We compute the beta function at one loop for Yang-Mills theory using as regulator the combination of higher covariant derivatives and Pauli-Villars determinants proposed by Faddeev and Slavnov. This regularization prescription has the appealing feature that it is manifestly gauge invariant and essentially four-dimensional. It happens however that the one-loop coefficient in the beta function that it yields is not -11/3, as it should be, but -23/6. The difference is due to unphysical logarithmic radiative corrections generated by the Pauli-Villars determinants on which the regularization method is based. This no-go result discards the prescription as a viable gauge invariant regularization, thus solving a long-standing open question in the literature. We also observe that the precsription can be modified so as to not generate unphysical logarithmic corrections, but at the expense of losing manifest gauge invariance. (orig.)

A simple football injury leading to a grade 4 renal trauma.

Science.gov (United States)

Fanning, Deirdre Mary; Forde, James C; Mohan, Ponnusamy

2012-03-08

This case highlights the need for cautious management and serial regular examination of trauma patients. A 22-year-old Caucasian male presented to the emergency department 4 h following an injury sustained during football training. He complained of the immediate onset of severe left upper quadrant and left flank pain. He subsequently developed frank haematuria. On initial review, he was haemodynamically stable. CT of the abdomen and pelvis showed a grade 4 renal trauma. Over the following 36 h, he remained haemodynamically stable. On serial abdominal examinations however, he developed a rigid abdomen and was noted to have a haemoglobin drop. Interval CT scan showed a progression of his injury and the presence of a haemoperitoneum. An emergency laparotomy was performed resulting in a left nephrectomy. He made an uneventful recovery.

A simple football injury leading to a grade 4 renal trauma.

LENUS (Irish Health Repository)

Fanning, Deirdre Mary

2012-01-01

This case highlights the need for cautious management and serial regular examination of trauma patients. A 22-year-old Caucasian male presented to the emergency department 4 h following an injury sustained during football training. He complained of the immediate onset of severe left upper quadrant and left flank pain. He subsequently developed frank haematuria. On initial review, he was haemodynamically stable. CT of the abdomen and pelvis showed a grade 4 renal trauma. Over the following 36 h, he remained haemodynamically stable. On serial abdominal examinations however, he developed a rigid abdomen and was noted to have a haemoglobin drop. Interval CT scan showed a progression of his injury and the presence of a haemoperitoneum. An emergency laparotomy was performed resulting in a left nephrectomy. He made an uneventful recovery.

Comparative analysis of employment dynamics in leading and lagging rural regions of the EU, 1980-1997.

NARCIS (Netherlands)

Terluin, I.J.; Post, J.H.; Sjöström, Å.

1999-01-01

In this study a comparative analysis of factors hampering and encouraging the development of employment in 9 leading and 9 lagging regions in the EU during the 1980s and the first half of the 1990s is made. Derived from this comparative analysis, some lessons, which leading and lagging rural regions

Design of an Actinide Burning, Lead or Lead-Bismuth Cooled Reactor That Produces Low Cost Electricty - FY-02 Annual Report

Energy Technology Data Exchange (ETDEWEB)

Mac Donald, Philip Elsworth; Buongiorno, Jacopo

2002-10-01

The purpose of this collaborative Idaho National Engineering and Environmental Laboratory (INEEL) and Massachusetts Institute of Technology (MIT) Laboratory Directed Research and Development (LDRD) project is to investigate the suitability of lead or lead-bismuth cooled fast reactors for producing low-cost electricity as well as for actinide burning. The goal is to identify and analyze the key technical issues in core neutronics, materials, thermal-hydraulics, fuels, and economics associated with the development of this reactor concept. Work has been accomplished in four major areas of research: core neutronic design, plant engineering, material compatibility studies, and coolant activation. The publications derived from work on this project (since project inception) are listed in Appendix A. This is the third in a series of Annual Reports for this project, the others are also listed in Appendix A as FY-00 and FY-01 Annual Reports.

Plant derived antioxidants and antifibrotic drugs: past, present and future

Directory of Open Access Journals (Sweden)

Devaraj Ezhilarasan

2014-09-01

Full Text Available Hepatic fibrosis occurs as a wound-healing process after several forms of chronic hepatic injury. Activation and proliferation of hepatic stellate cells play pivotal role in the pathogenesis of hepatic fibrosis. Many researchers, from the therapeutic perspective, have focused their attention on searching for novel agents with inhibitory effects on hepatic stellate cells proliferation and activation to prevent hepatic fibrogenesis and a number of plant derived antioxidants have been tested as anti-fibrogenic agents, they generally suppress proliferation and collagen synthesis. Plants remain an imperative source of novel drugs, novel drug leads and new chemical entities. The plant based drug discovery resulted primarily in the development of antioxidant, anti-cancer and other anti-infectious agents and continues to contribute to the new leads in clinical trials. This review summarizes some of those most important plant derived anti-fibrotic drugs and their beneficial effects on experimentally induced hepatic fibrosis in vitro and in vivo. The plant derived antioxidant compounds described herein are curcumin, silymarin, silibinin, baicalein, resveratrol, salvianolic acids, tetrandine, quercetin and berberine. Studies from ours and as demonstrated by pervious workers much information has been accumulated over the past two decades through in vivo and in vitro. In light of those studies, it has been confirmed that plants derived antioxidants, particularly flavanoids, show a significant influence to block hepatic fibrosis regardless of any etiology. This review outlines recent progress in the use of plant derived drugs against experimentally induced liver fibrosis by in vitro and in vivo studies and summarizes the possible mechanisms anti-fibrotic effects of these compounds.

Investigation of the Dirac Equation by Using the Conformable Fractional Derivative

Science.gov (United States)

Mozaffari, F. S.; Hassanabadi, H.; Sobhani, H.; Chung, W. S.

2018-05-01

In this paper,the Dirac equation is constructed using the conformable fractional derivative so that in its limit for the fractional parameter, the normal version is recovered. Then, the Cornell potential is considered as the interaction of the system. In this case, the wave function and the energy eigenvalue equation are derived with the aim of the bi-confluent Heun functions. use of the conformable fractional derivative is proven to lead to a branching treatment for the energy of the system. Such a treatment is obvious for small values of the fractional parameter, and a united value as the fractional parameter approaches unity.

Plant-Derived Antimalarial Agents: New Leads and Efficient Phytomedicines. Part II. Non-Alkaloidal Natural Products

Directory of Open Access Journals (Sweden)

Alaíde Braga de Oliveira

2009-08-01

Full Text Available Malaria is still the most destructive and dangerous parasitic infection in many tropical and subtropical countries. The burden of this disease is getting worse, mainly due to the increasing resistance of Plasmodium falciparum against the widely available antimalarial drugs. There is an urgent need for new, more affordable and accessible antimalarial agents possessing original modes of action. Natural products have played a dominant role in the discovery of leads for the development of drugs to treat human diseases, and this fact anticipates that new antimalarial leads may certainly emerge from tropical plant sources. This present review covers most of the recently-published non-alkaloidal natural compounds from plants with antiplasmodial and antimalarial properties, belonging to the classes of terpenes, limonoids, flavonoids, chromones, xanthones, anthraquinones, miscellaneous and related compounds, besides the majority of papers describing antiplasmodial crude extracts published in the last five years not reviewed before. In addition, some perspectives and remarks on the development of new drugs and phytomedicines for malaria are succinctly discussed.

Anti-cancer activities of diospyrin, its derivatives and analogues

KAUST Repository

Sagar, Sunil; Kaur, Mandeep; Minneman, Kenneth P.; Bajic, Vladimir B.

2010-01-01

Natural products have played a vital role in drug discovery and development process for cancer. Diospyrin, a plant based bisnaphthoquinonoid, has been used as a lead molecule in an effort to develop anti-cancer drugs. Several derivatives/analogues have been synthesized and screened for their pro-apoptotic/anti-cancer activities so far. Our review is focused on the pro-apoptotic/anti-cancer activities of diospyrin, its derivatives/analogues and the different mechanisms potentially involved in the bioactivity of these compounds. Particular focus has been placed on the different mechanisms (both chemical and molecular) thought to underlie the bioactivity of these compounds. A brief bioinformatics analysis at the end of the article provides novel insights into the new potential mechanisms and pathways by which these compounds might exert their effects and lead to a better realization of the full therapeutic potential of these compounds as anti-cancer drugs. © 2010 Elsevier Masson SAS. All rights reserved.

Anti-cancer activities of diospyrin, its derivatives and analogues

KAUST Repository

Sagar, Sunil

2010-09-01

Natural products have played a vital role in drug discovery and development process for cancer. Diospyrin, a plant based bisnaphthoquinonoid, has been used as a lead molecule in an effort to develop anti-cancer drugs. Several derivatives/analogues have been synthesized and screened for their pro-apoptotic/anti-cancer activities so far. Our review is focused on the pro-apoptotic/anti-cancer activities of diospyrin, its derivatives/analogues and the different mechanisms potentially involved in the bioactivity of these compounds. Particular focus has been placed on the different mechanisms (both chemical and molecular) thought to underlie the bioactivity of these compounds. A brief bioinformatics analysis at the end of the article provides novel insights into the new potential mechanisms and pathways by which these compounds might exert their effects and lead to a better realization of the full therapeutic potential of these compounds as anti-cancer drugs. © 2010 Elsevier Masson SAS. All rights reserved.

Scalar potential from higher derivative N=1 superspace

International Nuclear Information System (INIS)

Ciupke, David

2016-05-01

The supersymmetric completion of higher-derivative operators often requires introducing corrections to the scalar potential. In this paper we study these corrections systematically in the context of theories with N=1 global and local supersymmetry in D=4 focusing on ungauged chiral multiplets. In globally supersymmetric theories the most general off-shell effective scalar potential can be captured by a dependence of the Kaehler potential on additional chiral superfields. For supergravity we find a much richer structure of possible corrections. In this context we classify the leading order and next-to-leading order superspace derivative operators and determine the component forms of a subclass thereof. Moreover, we present an algorithm that simplifies the computation of the respective on-shell action. As particular applications we study the structure of the supersymmetric vacua for these theories and comment on the form of the corrections to shift-symmetric no-scale models. These results are relevant for the computation of effective actions for string compactifications and, in turn, for moduli stabilization and string inflation.

Total contribution of airborne lead to blood lead.

OpenAIRE

Manton, W I

1985-01-01

A nine year study of blood lead concentrations and isotope ratios carried out on a married couple shows that pulmonary deposition cannot account for all the airborne lead in blood; that lead from bone may comprise 70% of blood lead; and that during pregnancy blood lead may double due to mobilisation of lead from bone.

Placenta-derived exosomes: potential biomarkers of preeclampsia.

Science.gov (United States)

Pillay, Preenan; Moodley, Kogi; Moodley, Jagidesa; Mackraj, Irene

2017-01-01

Preeclampsia remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the lack of clarity on the etiology of the disorder. Although several clinical and biological markers of preeclampsia have been evaluated, they have proven to be ineffective in providing a definitive diagnosis during the various stages of the disorder. Exosomes have emerged as ideal biomarkers of pathological states, such as cancer, and have more recently gained interest in pregnancy-related complications, due to their role in cellular communication in normal and complicated pregnancies. This occurs as a result of the specific placenta-derived exosomal molecular cargo, which may be involved in normal pregnancy-associated immunological events, such as the maintenance of maternal-fetal tolerance. This review provides perspectives on placenta-derived exosomes as possible biomarkers for the diagnosis/prognosis of preeclampsia. Using keywords, online databases were searched to identify relevant publications to review the potential use of placenta-derived exosomes as biomarkers of preeclampsia.

Synthesis of Various Polyaniline / Clay Nanocomposites Derived from Aniline and Substituted Aniline Derivatives by Mechanochemical Intercalation Method

Directory of Open Access Journals (Sweden)

N. Kalaivasan

2010-01-01

Full Text Available Polyaniline clay nanocomposite can be prepared by mechano-chemical method in which intercalation of anilinium ion into the clay lattices accomplished by mechanical grinding of sodium montmorillonite (Na+MMT in presence of anilinium hydrochloride at room temperature using mortar & pestle for about 30 min and subsequent grinding with oxidizing agent, ammonium peroxysulfate. The appearance of green colour indicates the formation of polyaniline/clay nanocomposite (PANI/Clay. Similarly aniline derivatives like o-toludine and o-anisidine in the form of HCl salt can form intercalation into the clay lattices. The intercalated aniline derivatives were ground mechanically in presence of oxidizing agent ammonium peroxysulfate lead to formation of substituted polyaniline/ clay nanocomposites. The characteristics of various polyaniline-clay nanocomposites were investigated using UV-Visible, FT-IR, cyclic voltammetry studies.

Total contribution of airborne lead to blood lead.

Science.gov (United States)

Manton, W I

1985-01-01

A nine year study of blood lead concentrations and isotope ratios carried out on a married couple shows that pulmonary deposition cannot account for all the airborne lead in blood; that lead from bone may comprise 70% of blood lead; and that during pregnancy blood lead may double due to mobilisation of lead from bone. PMID:3970881

Toxic effects of lead on neuronal development and function

International Nuclear Information System (INIS)

Freedman, R.; Olson, L.; Hoffer, B.J.

1990-01-01

The effects of lead on the development of the nervous system are of immediate concern to human health. While it is clear that lead can affect neuronal development at levels of exposure within the range found in the environment, the particular mechanism of the disruption is not readily ascertained. The goal of the authors research is to develop a model system in which the effects of lead on central nervous system development can be demonstrated. To study neuronal development in a system that minimizes such difficulties, the authors have grafted discrete brain regions derived from rat fetuses into the anterior chamber of the eye of adult hosts. The brain pieces continue organotypic development in the eye, but are isolated from possible secondary changes due to alterations in the development of the endocrine and other somatic systems because the adult host has these systems already fully developed. Using this system, they have discovered that lead induces a hypernoradrenergic innervation of central nervous system tissue. The increased innervation is observed not only structurally, but also functionally. Since norepinephrine is an inhibitory neurotransmitter, this ingrowth may explain the profound slowing of discharge of cerebellar neurons recorded in grafts of lead-treated animals. Studies in other tissues suggest that increased axonal ingrowth may be a general problem of lead intoxication that encompasses many brain areas, as well as peripheral sympathetic systems

Lead- or Lead-bismuth-cooled fast reactors

International Nuclear Information System (INIS)

Bouchter, J.C.; Courouau, J.L.; Dufour, P.; Guidez, J.; Latge, C.; Martinelli, L.; Renault, C.; Rimpault, G.

2014-01-01

Lead-cooled fast reactors are one of the 6 concepts retained for the 4. generation of nuclear reactors. So far no lead-cooled reactors have existed in the world except lead-bismuth-cooled reactors in soviet submarines. Some problems linked to the use of the lead-bismuth eutectic appeared but were satisfactorily solved by a more rigorous monitoring of the chemistry of the lead-bismuth coolant. Lead presents various advantages as a coolant: no reactivity with water and the air,a high boiling temperature and low contamination when irradiated. The main asset of the lead-bismuth alloy is the drop of the fusion temperature from 327 C degrees to 125 C degrees. The main drawback of using lead (or lead-bismuth) is its high corrosiveness with metals like iron, chromium and nickel. The high corrosiveness of the coolant implies low flow velocities which means a bigger core and consequently a bigger reactor containment. Different research programs in the world (in Europe, Russia and the USA) are reviewed in the article but it appears that the development of this type of reactor requires technological breakthroughs concerning materials and the resistance to corrosion. Furthermore the concept of lead-cooled reactors seems to be associated to a range of low output power because of the compromise between the size of the reactor and its resistance to earthquakes. (A.C.)

Lead in teeth from lead-dosed goats: Microdistribution and relationship to the cumulative lead dose

International Nuclear Information System (INIS)

Bellis, David J.; Hetter, Katherine M.; Jones, Joseph; Amarasiriwardena, Dula; Parsons, Patrick J.

2008-01-01

Teeth are commonly used as a biomarker of long-term lead exposure. There appear to be few data, however, on the content or distribution of lead in teeth where data on specific lead intake (dose) are also available. This study describes the analysis of a convenience sample of teeth from animals that were dosed with lead for other purposes, i.e., a proficiency testing program for blood lead. Lead concentration of whole teeth obtained from 23 animals, as determined by atomic absorption spectrometry, varied from 0.6 to 80 μg g -1 . Linear regression of whole tooth lead (μg g -1 ) on the cumulative lead dose received by the animal (g) yielded a slope of 1.2, with r 2 =0.647 (p -1 , were found in circumpulpal dentine. Linear regression of circumpulpal lead (μg g -1 ) on cumulative lead dose (g) yielded a slope of 23 with r 2 =0.961 (p=0.0001). The data indicated that whole tooth lead, and especially circumpulpal lead, of dosed goats increased linearly with cumulative lead exposure. These data suggest that circumpulpal dentine is a better biomarker of cumulative lead exposure than is whole tooth lead, at least for lead-dosed goats

Analysis of neighborhood behavior in lead optimization and array design.

Science.gov (United States)

Papadatos, George; Cooper, Anthony W J; Kadirkamanathan, Visakan; Macdonald, Simon J F; McLay, Iain M; Pickett, Stephen D; Pritchard, John M; Willett, Peter; Gillet, Valerie J

2009-02-01

Neighborhood behavior describes the extent to which small structural changes defined by a molecular descriptor are likely to lead to small property changes. This study evaluates two methods for the quantification of neighborhood behavior: the optimal diagonal method of Patterson et al. and the optimality criterion method of Horvath and Jeandenans. The methods are evaluated using twelve different types of fingerprint (both 2D and 3D) with screening data derived from several lead optimization projects at GlaxoSmithKline. The principal focus of the work is the design of chemical arrays during lead optimization, and the study hence considers not only biological activity but also important drug properties such as metabolic stability, permeability, and lipophilicity. Evidence is provided to suggest that the optimality criterion method may provide a better quantitative description of neighborhood behavior than the optimal diagonal method.

DOE-Supported Physicists are Co-Winners of 2004 Nobel Prize in Physics

Science.gov (United States)

in Physics WASHINGTON, DC -- "On behalf of the U.S. Department of Energy, I congratulate Frank Wilczek, H. David Politzer and David J. Gross for winning the 2004 Nobel Prize in Physics," said agencies, have been the leading Federal supporter of research in physics, enabling vital advances and

A Brief Musing on the Events leading up to the Digitising of the VSS Observation Records

Science.gov (United States)

McIntosh, Ranald

2005-03-01

I first met, or I should say, 'sighted' Dr Frank Bateson somewhere around the middle of the last century when he was sojourning at Mt John. I was returning from a 2-week skiing holiday at Mt Cook when the bus our party was on made a detour up Mt John as the driver thought we might be interested. In Interested we all were, but my main memories of that visit were the kindly gentleman with 'the fog-horn voice' and the holes under the accommodation hut where the rabbits lived in the winter to keep warm.

Hydrogenation of imines catalysed by ruthenium(II) complexes based on lutidine-derived CNC pincer ligands.

Science.gov (United States)

Hernández-Juárez, Martín; Vaquero, Mónica; Álvarez, Eleuterio; Salazar, Verónica; Suárez, Andrés

2013-01-14

The preparation of new Ru(II) complexes incorporating fac-coordinated lutidine-derived CNC ligands is reported. These derivatives are selectively deprotonated by (t)BuOK at one of the methylene arms of the pincer, leading to catalytically active species in the hydrogenation of imines.

Development of proposed free release criteria for Idaho National Engineering Laboratory lead

International Nuclear Information System (INIS)

Losinski, S.J.

1994-01-01

The INEL Lead Management Project (LMP) performed an investigation of the origin of lead used as shielding at the INEL and developed radiological profile information that was then used to establish a baseline for the DOE ''no-rad-added'' standard. Primary findings of the investigation include the following: (a) Much of the lead at the INEL was obtained from a DOE lead bank; (b) Lead inventory at the DOE lead bank was derived primarily from recycled sources and was most likely in the form of pure lead; (c) Secondary lead (lead from recycled sources), available in today's market, is expected to have radiological characteristics similar to those of the DOE lead bank; (d) Highly sensitive radiological testing of 20 samples of lead from secondary sources revealed the lead to be radiologically pristine. Beta-, gamma-, and alpha-emitting radionuclide concentrations were all found to be less than detectable, except for a very small quantity of lead-210 (an alpha emitter), which is a naturally occurring isotope of lead. Based on the pristine nature of lead, a proposed free release criterion for lead was developed based on a statistical null hypothesis approach. The free release criterion compares the natural background count of a clean lead standard with the natural background count of a sample. When the sample background count cannot be distinguished as different from the standard background count at the 95% confidence level, then the sample is considered radiologically clean

A Note on the Effect of Wind Waves on Vertical Mixing in Franks Tract, Sacramento–San Joaquin Delta, California

Directory of Open Access Journals (Sweden)

Nicole L. Jones

2008-06-01

Full Text Available A one-dimensional numerical model that simulates the effects of whitecapping waves was used to investigate the importance of whitecapping waves to vertical mixing at a 3-meter-deep site in Franks Tract in the Sacramento-San Joaquin Delta over an 11-day period. Locally-generated waves of mean period approximately 2 s were generated under strong wind conditions; significant wave heights ranged from 0 to 0.3 m. A surface turbulent kinetic energy flux was used to model whitecapping waves during periods when wind speeds > 5 m s-1 (62% of observations. The surface was modeled as a wind stress log-layer for the remaining 38% of the observations. The model results demonstrated that under moderate wind conditions (5–8 m s-1 at 10 m above water level, and hence moderate wave heights, whitecapping waves provided the dominant source of turbulent kinetic energy to only the top 10% of the water column. Under stronger wind (> 8 m s-1, and hence larger wave conditions, whitecapping waves provided the dominant source of turbulent kinetic energy over a larger portion of the water column; however, this region extended to the bottom half of the water column for only 7% of the observation period. The model results indicated that phytoplankton concentrations close to the bed were unlikely to be affected by the whitecapping of waves, and that the formation of concentration boundary layers due to benthic grazing was unlikely to be disrupted by whitecapping waves. Furthermore, vertical mixing of suspended sediment was unlikely to be affected by whitecapping waves under the conditions experienced during the 11-day experiment. Instead, the bed stress provided by tidal currents was the dominant source of turbulent kinetic energy over the bottom half of the water column for the majority of the 11-day period.

Polymer-Derived Boron Nitride: A Review on the Chemistry, Shaping and Ceramic Conversion of Borazine Derivatives.

Science.gov (United States)

Bernard, Samuel; Miele, Philippe

2014-11-21

Boron nitride (BN) is a III-V compound which is the focus of important research since its discovery in the early 19th century. BN is electronic to carbon and thus, in the same way that carbon exists as graphite, BN exists in the hexagonal phase. The latter offers an unusual combination of properties that cannot be found in any other ceramics. However, these properties closely depend on the synthesis processes. This review states the recent developments in the preparation of BN through the chemistry, shaping and ceramic conversion of borazine derivatives. This concept denoted as Polymer-Derived Ceramics (PDCs) route allows tailoring the chemistry of precursors to elaborate complex BN shapes which cannot be obtained by conventional process. The effect of the chemistry of the molecular precursors, i.e. , borazine and trichloroborazine, and their polymeric derivatives i.e. , polyborazylene and poly[tri(methylamino)borazine], in which the specific functional groups and structural motifs determine the shaping potential by conventional liquid-phase process and plastic-forming techniques is discussed. Nanotubes, nano-fibers, coatings, monoliths and fiber-reinforced matrix composites are especially described. This leads to materials which are of significant engineering interest.

Polymer-Derived Boron Nitride: A Review on the Chemistry, Shaping and Ceramic Conversion of Borazine Derivatives

Directory of Open Access Journals (Sweden)

Samuel Bernard

2014-11-01

Full Text Available Boron nitride (BN is a III-V compound which is the focus of important research since its discovery in the early 19th century. BN is electronic to carbon and thus, in the same way that carbon exists as graphite, BN exists in the hexagonal phase. The latter offers an unusual combination of properties that cannot be found in any other ceramics. However, these properties closely depend on the synthesis processes. This review states the recent developments in the preparation of BN through the chemistry, shaping and ceramic conversion of borazine derivatives. This concept denoted as Polymer-Derived Ceramics (PDCs route allows tailoring the chemistry of precursors to elaborate complex BN shapes which cannot be obtained by conventional process. The effect of the chemistry of the molecular precursors, i.e., borazine and trichloroborazine, and their polymeric derivatives i.e., polyborazylene and poly[tri(methylaminoborazine], in which the specific functional groups and structural motifs determine the shaping potential by conventional liquid-phase process and plastic-forming techniques is discussed. Nanotubes, nano-fibers, coatings, monoliths and fiber-reinforced matrix composites are especially described. This leads to materials which are of significant engineering interest.

The optimum lead thickness for lead-activation detectors

International Nuclear Information System (INIS)

Si Fenni; Hu Qingyuan

2009-01-01

The optimum lead thickness for lead-activation detectors has been studied in this paper. First existence of the optimum lead thickness is explained theoretically. Then the optimum lead thickness is obtained by two methods, MCNP5 calculation and mathematical estimation. At last factors which affect the optimum lead thickness are discussed. It turns out that the optimum lead thickness is irrelevant to incident neutron energies. It is recommended 2.5 cm generally.

Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy.

Science.gov (United States)

Kudou, Naoki; Taniguchi, Akira; Sugimoto, Kenji; Matsuya, Yuji; Kawasaki, Masashi; Toyooka, Naoki; Miyoshi, Chika; Awale, Suresh; Dibwe, Dya Fita; Esumi, Hiroyasu; Kadota, Shigetoshi; Tezuka, Yasuhiro

2013-02-01

A series of new (-)-arctigenin derivatives with variably modified O-alkyl groups were synthesized and their preferential cytotoxicity was evaluated against human pancreatic cancer cell line PANC-1 under nutrient-deprived conditions. The results showed that monoethoxy derivative 4i (PC(50), 0.49 μM), diethoxy derivative 4h (PC(50), 0.66 μM), and triethoxy derivative 4m (PC(50), 0.78 μM) showed the preferential cytotoxicities under nutrient-deprived conditions, which were identical to or more potent than (-)-arctigenin (1) (PC(50), 0.80 μM). Among them, we selected the triethoxy derivative 4m and examined its in vivo antitumor activity using a mouse xenograft model. Triethoxy derivative 4m exhibited also in vivo antitumor activity with the potency identical to or slightly more than (-)-arctigenin (1). These results would suggest that a modification of (-)-arctigenin structure could lead to a new drug based on the antiausterity strategy. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.

Science.gov (United States)

Ting, Pauline C; Lee, Joe F; Zorn, Nicolas; Kim, Hyunjin M; Aslanian, Robert G; Lin, Mingxiang; Smith, Michelle; Walker, Scott S; Cook, John; Van Heek, Margaret; Lachowicz, Jean

2013-02-15

The structure-activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described. The optimization of the initial lead compound 6 based on in vitro and in vivo activity led to the discovery of key compounds 10j and 17h. Copyright © 2013 Elsevier Ltd. All rights reserved.

Lead and cadmium in indoor air and the urban environment

International Nuclear Information System (INIS)

Komarnicki, Guenter J.K.

2005-01-01

The present study was conducted to find potential terrestrial biomonitors for heavy metals in indoor air in an urban environment. TSP, PM 10 , and PM 2.5 were collected in three retirement facilities in the urban area of Vienna. In addition, particulate matter and soil, vegetation, and isopods (Porcellio scaber L.) were collected in the adjacent garden areas. Aerosols were sampled with a low-volume air sampler. The sampled materials were wet ashed and total lead and cadmium contents were determined. Water-soluble heavy metal concentrations were measured in aqueous extracts from air exposed filters, soil, and vegetation. Lead and cadmium were analyzed by graphite furnace AAS. Lead contents in the vegetation were inferred from water-soluble lead in soils. Lead in isopods generally reflected the contents in vegetation. Cadmium in plants probably derived from soil solutions as well as from atmospheric input. Isopods reflected the total cadmium contents in soils. Particulate matter was dominated by PM 2.5 , both with respect to mass concentrations and to heavy metal contents. The indoor aerosol was found to be influenced by human activity, indoor sources, and outdoor particles. Relationships between indoor airborne heavy metals and the contents in vegetation (lead and cadmium: positive) and isopods (lead: negative) were identified to have the potential for biomonitoring indoor air quality. - Urban vegetation and isopods are potential indicators for indoor aerial heavy metals

Morphology of enamel in primary teeth from children in Thailand exposed to environmental lead

International Nuclear Information System (INIS)

Youravong, Nattaporn; Chongsuvivatwong, Virasakdi; Teanpaisan, Rawee; Geater, Alan F.; Dietz, Wolfram; Dahlen, Gunnar; Noren, Joergen G.

2005-01-01

Lead is one of the major environmental pollutants and a health risk. Dental hard tissues have a capacity to accumulate lead from the environment. Eighty exfoliated primary teeth were collected from children residing around a shipyard area in southern Thailand, known for its lead contamination. The morphology of the enamel was examined by polarized light microscopy (PLM), microradiography (MRG), and scanning electron microscopy (SEM). The specimens derived from two groups of children, one group with high blood levels of lead (57 teeth) and one group having low blood levels of lead (23 teeth). The enamel irrespective of group appeared normal. However, in a majority of the specimens the enamel surface appeared hypomineralized, which was confirmed in SEM. No morphological changes connected to lead in blood could be found. The hypomineralized surface zone could possibly be attributed to an acid oral environment

Morphology of enamel in primary teeth from children in Thailand exposed to environmental lead

Energy Technology Data Exchange (ETDEWEB)

Youravong, Nattaporn [Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Songkhla (Thailand); Chongsuvivatwong, Virasakdi [Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Songkhla (Thailand); Teanpaisan, Rawee [Department of Stomatology, Faculty of Dentistry, Prince of Songkla University, Songkhla (Thailand); Geater, Alan F. [Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Songkhla (Thailand); Dietz, Wolfram [Centre of Electron Microscopy, Friedrich-Schiller-University Jena (Germany); Dahlen, Gunnar [Department of Oral Microbiology, Faculty of Odontology, Goeteborg University (Sweden); Noren, Joergen G. [Department of Pedodontics, Faculty of Odontology, Goeteborg University, Box 450 SE-405 30 Goeteborg (Sweden)]. E-mail: Jorgen.noren@odontologi.gu.se

2005-09-15

Lead is one of the major environmental pollutants and a health risk. Dental hard tissues have a capacity to accumulate lead from the environment. Eighty exfoliated primary teeth were collected from children residing around a shipyard area in southern Thailand, known for its lead contamination. The morphology of the enamel was examined by polarized light microscopy (PLM), microradiography (MRG), and scanning electron microscopy (SEM). The specimens derived from two groups of children, one group with high blood levels of lead (57 teeth) and one group having low blood levels of lead (23 teeth). The enamel irrespective of group appeared normal. However, in a majority of the specimens the enamel surface appeared hypomineralized, which was confirmed in SEM. No morphological changes connected to lead in blood could be found. The hypomineralized surface zone could possibly be attributed to an acid oral environment.

Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation

DEFF Research Database (Denmark)

Clayton, Emma L.; Mancuso, Renzo; Nielsen, Troels Tolstrup

2017-01-01

Frontotemporal dementia (FTD)-causing mutations in the CHMP2B gene lead to the generation of mutant C-terminally truncated CHMP2B. We report that transgenic mice expressing endogenous levels of mutant CHMP2B developed late-onset brain volume loss associated with frank neuronal loss and FTD-like c...

Reduction of myeloid suppressor cell derived nitric oxide provides a mechanistic basis of lead enhancement of alloreactive CD4+ T cell proliferation

International Nuclear Information System (INIS)

Farrer, David G.; Hueber, Sara; Laiosa, Michael D.; Eckles, Kevin G.; McCabe, Michael J.

2008-01-01

The persistent environmental toxicant and immunomodulator, lead (Pb), has been proposed to directly target CD4 + T cells. However, our studies suggest that CD4 + T cells are an important functional, yet indirect target. In order to identify the direct target of Pb in the immune system and the potential mechanism of Pb-induced immunotoxicity, myeloid suppressor cells (MSCs) were evaluated for their ability to modulate CD4 + T cell proliferation after Pb exposure. Myeloid suppressor cells regulate the adaptive immune response, in part, by inhibiting the proliferation of CD4 + T cells. It is thought that the mechanism of MSC-dependent regulation involves the release of the bioactive gas, nitric oxide (NO), blocking cell signaling cascades downstream of the IL-2 receptor and thus preventing T cells from entering cell-cycle. In mixed lymphocyte culture (MLC), increasing numbers of MSCs suppressed T cell proliferation in a dose-dependent manner, and this suppression is strikingly abrogated with 5 μM lead (Pb) treatment. The Pb-sensitive MSC population is CD11b + , GR1 + and CD11c - and thus phenotypically consistent with MSCs described in other literature. Inhibition of NO-synthase (NOS), the enzyme responsible for the production of NO, enhanced alloreactive T cell proliferation in MLC. Moreover, Pb attenuated NO production in MLC, and exogenous replacement of NO restored suppression in the presence of Pb. Significantly, MSC from iNOS-/- mice were unable to suppress T cell proliferation. An MSC-derived cell line (MSC-1) also suppressed T cell proliferation in MLC, and Pb disrupted this suppression by attenuating NO production. Additionally, Pb disrupted NO production in MSC-1 cells in response to treatment with interferon-γ (IFN-γ) and LPS or in response to concanavalin A-stimulated splenocytes. However, neither the abundance of protein nor levels of mRNA for the inducible isoform of NOS (iNOS) were altered with Pb treatment. Taken together these data suggest that Pb

Josef Frank and the history of architecture: Gothic and the Renaissance, Leon Battista Alberti and Albrecht Dürer in the architectural discourse on Neues Bauen at the beginning of the 1930s

Directory of Open Access Journals (Sweden)

Caterina Cardemone

2016-06-01

Full Text Available The paper focuses on Josef Frank’s convinced use of historiographical arguments in his sharp critique of German modernist architecture. Frank’s attention to architectural history dates back to his education at the Technische Hochschule in Vienna, with Carl König, and the writing of a doctoral thesis on Leon Battista Alberti’s religious buildings in 1910. If a profound knowledge of Alberti’s writings informs Frank’s entire theoretical work, the point discussed here is the parallel between Neues Bauen and Gothic traced by Frank to exclude Neues Bauen from a true modernity, based, on the opposite, on a classical tradition of thought. An attempt is made to reconstruct Frank’s historiographical references and to insert his work in the broader historiographical context, thus highlighting a close link between architectural theory and critique on the one hand and contemporary historiographical constructions on the other.

Exploring the novel heterocyclic derivatives as lead molecules for design and development of potent anticancer agents.

Science.gov (United States)

Azad, Iqbal; Nasibullah, Malik; Khan, Tahmeena; Hassan, Firoj; Akhter, Yusuf

2018-05-01

This paper deals with in silico evaluation of newly proposed heterocyclic derivatives in search of potential anticancer activity. Best possible drug candidates have been proposed using a rational approach employing a pipeline of computational techniques namely MetaPrint2D prediction, molinspiration, cheminformatics, Osiris Data warrior, AutoDock and iGEMDOCK. Lazar toxicity prediction, AdmetSAR predictions, and targeted docking studies were also performed. 27 heterocyclic derivatives were selected for bioactivity prediction and drug likeness score on the basis of Lipinski's rule, Viber rule, Ghose filter, leadlikeness and Pan Assay Interference Compounds (PAINS) rule. Bufuralol, Sunitinib, and Doxorubicin were selected as reference standard drug for the comparison of molecular descriptors and docking. Bufuralol is a known non-selective adreno-receptor blocking agent. Studies showed that beta blockers are also used against different types of cancers. Sunitinib is well known Food and Drug administration (FDA) approved pyrrole containing tyrosine kinase inhibitor and our proposed molecules possess similarities with both drug and doxorubicin is another moiety having anticancer activity. All heterocyclic derivatives were found to obey the drug filters except standard drug Doxorubicin. Bioactivity score of the compounds was predicted for drug targets including enzymes, nuclear receptors, kinase inhibitors, G protein-coupled receptor (GPCR) ligands and ion channel modulators. Absorption, distribution, metabolism and toxicity (ADMET) prediction of all proposed compound showed good Blood-brain barrier (BBB) penetration, Human intestinal absorption (HIA), Caco-2 cell permeability except compound-11 and was found to have no AdmetSAR toxicity as well as carcinogenic effect. Compounds 1-9 were slightly mutagenic while compound 2, 11, 20 and 21 showed carcinogenic effect according to Lazar toxicity prediction. Rests of the compounds were predicted to have no side effect

Synthetic lead bromapatite: X-ray structure at ambient pressure and compressibility up to about 20 GPa

Science.gov (United States)

Liu, Xi; Fleet, Michael E.; Shieh, Sean R.; He, Qiang

2011-05-01

Lead bromapatite [Pb10(PO4)6Br2] has been synthesized via solid-state reaction at pressures up to 1.0 GPa, and its structure determined by single-crystal X-ray diffraction at ambient temperature and pressure. The large bromide anion is accommodated in the c-axis channel by lateral displacements of structural elements, particularly of Pb2 cations and PO4 tetrahedra. The compressibility of bromapatite was also investigated up to about 20.7 GPa at ambient temperature, using a diamond-anvil cell and synchrotron X-ray radiation. The compressibility of lead bromapatite is significantly different from that of lead fluorapatite. The pressure-volume data of lead bromapatite ( P < 10 GPa) fitted to the third-order Birch-Murnaghan equation yield an isothermal bulk modulus ( K T ) of 49.8(16) GPa and first pressure derivative ( KT^' } ) of 10.1(10). If KT^' } is fixed at 4, the derived K T is 60.8(11) GPa. The relative difference of the bulk moduli of these two lead apatites is thus about 12%, which is about two times the relative difference of the bulk moduli (~5%) of the calcium apatites fluorapatite [Ca10(PO4)6F2], chlorapatite [Ca10(PO4)6Cl2] and hydroxylapatite [Ca10(PO4)6(OH)2]. Another interesting feature apparently related to the replacement of F by Br in lead apatite is the switch in the principle axes of the strain ellipsoid: the c-axis is less compressible than the a-axis in lead bromapatite but more compressible in lead fluorapatite.

Immunomodulatory and Anti-Inflammatory Activities of Chicken Cathelicidin-2 Derived Peptides

Science.gov (United States)

van Dijk, Albert; van Eldik, Mandy; Veldhuizen, Edwin J. A.; Tjeerdsma-van Bokhoven, Hanne L. M.; de Zoete, Marcel R.; Bikker, Floris J.; Haagsman, Henk P.

2016-01-01

Host Defence Peptides and derived peptides are promising classes of antimicrobial and immunomodulatory lead compounds. For this purpose we examined whether chicken cathelicidin-2 (CATH-2)-derived peptides modulate the function and inflammatory response of avian immune cells. Using a chicken macrophage cell line (HD11) we found that full-length CATH-2 dose-dependently induced transcription of chemokines CXCLi2/IL-8, MCP-3 and CCLi4/RANTES, but not of pro-inflammatory cytokine IL-1β. In addition, CATH-2 efficiently inhibited IL-1β and nitric oxide production by HD11 cells induced by different sources of lipopolysaccharides (LPS). N-terminal truncated CATH-2 derived peptides maintained the capacity to selectively induce chemokine transcription, but despite their high LPS affinity several analogs lacked LPS-neutralizing capacity. Substitution of phenylalanine residues by tryptophan introduced endotoxin neutralization capacity in inactive truncated CATH-2 derived peptides. In contrast, amino acid substitution of phenylalanine by tyrosine abrogated endotoxin neutralization activity of CATH-2 analogs. These findings support a pivotal role for aromatic residues in peptide-mediated endotoxin neutralization by CATH-2 analogs and were shown to be independent of LPS affinity. The capacity to modulate chemokine production and dampen endotoxin-induced pro-inflammatory responses in chicken immune cells implicates that small CATH-2 based peptides could serve as leads for the design of CATH-2 based immunomodulatory anti-infectives. PMID:26848845

Immunomodulatory and Anti-Inflammatory Activities of Chicken Cathelicidin-2 Derived Peptides.

Directory of Open Access Journals (Sweden)

Albert van Dijk

Full Text Available Host Defence Peptides and derived peptides are promising classes of antimicrobial and immunomodulatory lead compounds. For this purpose we examined whether chicken cathelicidin-2 (CATH-2-derived peptides modulate the function and inflammatory response of avian immune cells. Using a chicken macrophage cell line (HD11 we found that full-length CATH-2 dose-dependently induced transcription of chemokines CXCLi2/IL-8, MCP-3 and CCLi4/RANTES, but not of pro-inflammatory cytokine IL-1β. In addition, CATH-2 efficiently inhibited IL-1β and nitric oxide production by HD11 cells induced by different sources of lipopolysaccharides (LPS. N-terminal truncated CATH-2 derived peptides maintained the capacity to selectively induce chemokine transcription, but despite their high LPS affinity several analogs lacked LPS-neutralizing capacity. Substitution of phenylalanine residues by tryptophan introduced endotoxin neutralization capacity in inactive truncated CATH-2 derived peptides. In contrast, amino acid substitution of phenylalanine by tyrosine abrogated endotoxin neutralization activity of CATH-2 analogs. These findings support a pivotal role for aromatic residues in peptide-mediated endotoxin neutralization by CATH-2 analogs and were shown to be independent of LPS affinity. The capacity to modulate chemokine production and dampen endotoxin-induced pro-inflammatory responses in chicken immune cells implicates that small CATH-2 based peptides could serve as leads for the design of CATH-2 based immunomodulatory anti-infectives.

Lithium attenuates lead induced toxicity on mouse non-adherent bone marrow cells.

Science.gov (United States)

Banijamali, Mahsan; Rabbani-Chadegani, Azra; Shahhoseini, Maryam

2016-07-01

Lead is a poisonous heavy metal that occurs in all parts of environment and causes serious health problems in humans. The aim of the present study was to investigate the possible protective effect of lithium against lead nitrate induced toxicity in non-adherent bone marrow stem cells. Trypan blue and MTT assays represented that exposure of the cells to different concentrations of lead nitrate decreased viability in a dose dependent manner, whereas, pretreatment of the cells with lithium protected the cells against lead toxicity. Lead reduced the number and differentiation status of bone marrow-derived precursors when cultured in the presence of colony stimulating factor (CSF), while the effect was attenuated by lithium. The cells treated with lead nitrate exhibited cell shrinkage, DNA fragmentation, anion superoxide production, but lithium prevented lead action. Moreover, apoptotic indexes such as PARP cleavage and release of HMGB1 induced by lead, were protected by lithium, suggesting anti-apoptotic effect of lithium. Immunoblot analysis of histone H3K9 acetylation indicated that lithium overcame lead effect on acetylation. In conclusion, lithium efficiently reduces lead toxicity suggesting new insight into lithium action which may contribute to increased cell survival. It also provides a potentially new therapeutic strategy for lithium and a cost-effective approach to minimize destructive effects of lead on bone marrow stem cells. Copyright © 2016 Elsevier GmbH. All rights reserved.

The M/M/1 queue with inventory, lost sale and general lead times

DEFF Research Database (Denmark)

Saffari, Mohammad; Asmussen, Søren; Haji, Rasoul

We consider an M/M/1 queueing system with inventory under the (r,Q) policy and with lost sales, in which demands occur according to a Poisson process and service times are exponentially distributed. All arriving customers during stockout are lost. We derive the stationary distributions of the joint...... queue length (number of customers in the system) and on-hand inventory when lead times are random variables and can take various distributions. The derived stationary distributions are used to formulate long-run average performance measures and cost functions in some numerical examples....

A theoretical derivation of the condensed history algorithm

International Nuclear Information System (INIS)

Larsen, E.W.

1992-01-01

Although the Condensed History Algorithm is a successful and widely-used Monte Carlo method for solving electron transport problems, it has been derived only by an ad-hoc process based on physical reasoning. In this paper we show that the Condensed History Algorithm can be justified as a Monte Carlo simulation of an operator-split procedure in which the streaming, angular scattering, and slowing-down operators are separated within each time step. Different versions of the operator-split procedure lead to Ο(Δs) and Ο(Δs 2 ) versions of the method, where Δs is the path-length step. Our derivation also indicates that higher-order versions of the Condensed History Algorithm may be developed. (Author)

Particle size distributions of lead measured in battery manufacturing and secondary smelter facilities and implications in setting workplace lead exposure limits.

Science.gov (United States)

Petito Boyce, Catherine; Sax, Sonja N; Cohen, Joel M

2017-08-01

Inhalation plays an important role in exposures to lead in airborne particulate matter in occupational settings, and particle size determines where and how much of airborne lead is deposited in the respiratory tract and how much is subsequently absorbed into the body. Although some occupational airborne lead particle size data have been published, limited information is available reflecting current workplace conditions in the U.S. To address this data gap, the Battery Council International (BCI) conducted workplace monitoring studies at nine lead acid battery manufacturing facilities (BMFs) and five secondary smelter facilities (SSFs) across the U.S. This article presents the results of the BCI studies focusing on the particle size distributions calculated from Personal Marple Impactor sampling data and particle deposition estimates in each of the three major respiratory tract regions derived using the Multiple-Path Particle Dosimetry model. The BCI data showed the presence of predominantly larger-sized particles in the work environments evaluated, with average mass median aerodynamic diameters (MMADs) ranging from 21-32 µm for the three BMF job categories and from 15-25 µm for the five SSF job categories tested. The BCI data also indicated that the percentage of lead mass measured at the sampled facilities in the submicron range (i.e., lead) was generally small. The estimated average percentages of lead mass in the submicron range for the tested job categories ranged from 0.8-3.3% at the BMFs and from 0.44-6.1% at the SSFs. Variability was observed in the particle size distributions across job categories and facilities, and sensitivity analyses were conducted to explore this variability. The BCI results were compared with results reported in the scientific literature. Screening-level analyses were also conducted to explore the overall degree of lead absorption potentially associated with the observed particle size distributions and to identify key issues

Implications for wildlife and humans of dietary exposure to lead from fragments of lead rifle bullets in deer shot in the UK

International Nuclear Information System (INIS)

Knott, Jeff; Gilbert, Jo; Hoccom, David G.; Green, Rhys E.

2010-01-01

Lead poisoning caused by ingested spent lead shotgun pellets has long been known to be a cause of unnecessary mortality in waterfowl and has led to legislation limiting its use in many countries. Recent evidence has shown that the problem extends to terrestrial ecosystems and to fragmented rifle bullets eaten by scavengers as well as shotgun pellets. Dietary exposure of human consumers to lead from spent ammunition in game meat also poses potential risks to human health. To assess the degree of fragmentation of lead bullets used to kill wild deer, twelve deer were shot in the thorax using copper-jacketed lead-cored bullets, as part of planned deer management operations. The thoracic region of the eviscerated carcasses and the abdominal viscera of each deer were X-rayed. An average of 356 metal fragments was visible on radiographs of the carcass and 180 fragments in the viscera. The weight of fragments was estimated by reference to an X-rayed scale of fragments of known weight. The average total weight of metal fragments, likely to be mostly lead, was estimated to be 1.2 g for the carcass and 0.2 g for the viscera. The total estimated weight of fragments in the entire carcass was estimated to be 17% of the weight of the bullet. Most fragments were small in size, with those in the viscera being smaller than those in the carcass. Metal fragments in the viscera were sufficiently small that at least 80% of the metallic bullet-derived lead in the viscera would be expected to be ingested by scavenging birds, such as buzzards and eagles, which feed on them.

Implications for wildlife and humans of dietary exposure to lead from fragments of lead rifle bullets in deer shot in the UK

Energy Technology Data Exchange (ETDEWEB)

Knott, Jeff, E-mail: jeff.knott@rspb.org.uk [Royal Society for the Protection of Birds, The Lodge, Sandy, Bedfordshire SG19 2DL (United Kingdom); Gilbert, Jo; Hoccom, David G. [Royal Society for the Protection of Birds, The Lodge, Sandy, Bedfordshire SG19 2DL (United Kingdom); Green, Rhys E. [Royal Society for the Protection of Birds, The Lodge, Sandy, Bedfordshire SG19 2DL (United Kingdom); Conservation Science Group, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ (United Kingdom)

2010-12-01

Lead poisoning caused by ingested spent lead shotgun pellets has long been known to be a cause of unnecessary mortality in waterfowl and has led to legislation limiting its use in many countries. Recent evidence has shown that the problem extends to terrestrial ecosystems and to fragmented rifle bullets eaten by scavengers as well as shotgun pellets. Dietary exposure of human consumers to lead from spent ammunition in game meat also poses potential risks to human health. To assess the degree of fragmentation of lead bullets used to kill wild deer, twelve deer were shot in the thorax using copper-jacketed lead-cored bullets, as part of planned deer management operations. The thoracic region of the eviscerated carcasses and the abdominal viscera of each deer were X-rayed. An average of 356 metal fragments was visible on radiographs of the carcass and 180 fragments in the viscera. The weight of fragments was estimated by reference to an X-rayed scale of fragments of known weight. The average total weight of metal fragments, likely to be mostly lead, was estimated to be 1.2 g for the carcass and 0.2 g for the viscera. The total estimated weight of fragments in the entire carcass was estimated to be 17% of the weight of the bullet. Most fragments were small in size, with those in the viscera being smaller than those in the carcass. Metal fragments in the viscera were sufficiently small that at least 80% of the metallic bullet-derived lead in the viscera would be expected to be ingested by scavenging birds, such as buzzards and eagles, which feed on them.

A class of constitutive relations with internal variable derivatives: derivation from homogenization and initial value problem

International Nuclear Information System (INIS)

Andrieux, S.; Joussemet, M.; Lorentz, E.

1996-01-01

When they are subjected to excessive loads, some materials may exhibit a softening behaviour resulting from the deterioration of their mechanical properties. To idealize such behaviours, constitutive relations with softening are introduced, for which the size of the domain of reversibility in the stress-space decreases. These models feature a strain localization within the material, in agreement with experiments, but cannot predict the subsequent behaviour because they lead to shear bands the width of which is equal to zero, physically unacceptable and numerically troublesome. It has been proposed in the literature to overcome these difficulties by adding to the list of internal variable the spatial gradients of some of them. This procedure suffers from lack of firm methodological basis. Although, some quantitative justification have been advanced relying on some kind of microscopic analysis. Therefore, we propose to extend the classical (local) models by introducing the internal state variable first gradients. Given local model within the framework of standard generalized materials, consistent homogenization procedure is put forward to derive macroscopic free energy and dissipation potentials. The standard generalized character is preserved, with an extended set of state variables, containing not only the strain and the internal variables but also the internal variable derivatives. Nevertheless, when dealing with the whole structure, the independence between the new state variables is lost. We propose then to generalize the constitutive relations, leading to a new variational principle that ensures the Clausius-Duhem inequality at the structure scale. (authors)

The adjoint method for general EEG and MEG sensor-based lead field equations

International Nuclear Information System (INIS)

Vallaghe, Sylvain; Papadopoulo, Theodore; Clerc, Maureen

2009-01-01

Most of the methods for the inverse source problem in electroencephalography (EEG) and magnetoencephalography (MEG) use a lead field as an input. The lead field is the function which relates any source in the brain to its measurements at the sensors. For complex geometries, there is no analytical formula of the lead field. The common approach is to numerically compute the value of the lead field for a finite number of point sources (dipoles). There are several drawbacks: the model of the source space is fixed (a set of dipoles), and the computation can be expensive for as much as 10 000 dipoles. The common idea to bypass these problems is to compute the lead field from a sensor point of view. In this paper, we use the adjoint method to derive general EEG and MEG sensor-based lead field equations. Within a simple framework, we provide a complete review of the explicit lead field equations, and we are able to extend these equations to non-pointlike sensors.

Preparation and optical characteristics of layered perovskite-type lead-bromide-incorporated azobenzene chromophores

Science.gov (United States)

Sasai, Ryo; Shinomura, Hisashi

2013-02-01

Lead bromide-based layered perovskite powders with azobenzene derivatives were prepared by a homogeneous precipitation method. From the diffuse reflectance (DR) and photoluminescence (PL) spectra of the hybrid powder materials, the present hybrids exhibited sharp absorption and PL peaks originating from excitons produced in the PbBr42- layer. When the present hybrid powder was irradiated with UV light at 350 nm, the absorption band from the trans-azobenzene chromophore, observed around 350 nm, decreased, while the absorption band from the cis-azobenzene chromophore, observed around 450 nm, increased. These results indicate that azobenzene chromophores in the present hybrid materials exhibit reversible photoisomerization. Moreover, it was found that the PL intensity from the exciton also varied due to photoisomerization of the azobenzene chromophores in the present hybrid. Thus, for the first time we succeeded in preparing the azobenzene derivative lead-bromide-based layered perovskite with photochromism before and after UV light irradiation.

Lead poisoning

Energy Technology Data Exchange (ETDEWEB)

Beijers, J A

1952-01-01

Three cases of acute lead poisoning of cattle herds via ingestion are reported, and reference is made to several other incidents of lead in both humans and animals. The quantity of lead which was found in the livers of the dead cows varied from 6.5 to 19 mg/kg, while 1160 mg/kg of lead in the liver was found for a young cow which was poisoned experimentally with 5 gms of lead acetate per day; hence, there appears to be great variability in the amounts deposited that can lead to intoxication and death. No evidence was found for a lead seam around the teeth, prophyrinuria, or basophil granules in the erythrocytes during acute or chronic lead poisoning of cattle or horses examined. Reference is made to attempts of finding the boundary line between increased lead absorption and lead intoxication in humans, and an examination of 60 laborers in an offset-printing office containing a great deal of inhalable lead (0.16 to 1.9 mg/cu m air) is reviewed. Physical deviation, basophylic granulation of erythrocytes, increased lead content of the urine, and porphyrinuria only indicate an increased absorption of lead; the use of the term intoxication is justified if, in addition, there are complaints of lack of appetite, constipation, fatigue, abdominal pain, and emaciation.

Lead effects on development and function of bone marrow-derived dendritic cells promote Th2 immune responses

International Nuclear Information System (INIS)

Gao Donghong; Mondal, Tapan K.; Lawrence, David A.

2007-01-01

Although lead (Pb) has significant effects on the development and function of macrophages, B cells, and T cells and has been suggested to promote allergic asthma in mice and humans, Pb modulation of bone marrow (BM)-derived dendritic cells (DCs) and the resultant DC effects on Th1 and Th2 development have not been examined. Accordingly, we cultured BM cells with murine granulocyte macrophage-colony stimulating factor (mGM-CSF) ± PbCl 2 . At day 10, culture supernatant (SN) and non-adherent cells were harvested for analysis. Additionally, day 10 non-adherent BM-DCs were harvested and recultured with mGM-CSF + LPS ± Pb for 2 days. The day 10 Pb exposure significantly inhibited BM-DC generation, based on CD11c expression. Although fewer DCs were generated with Pb, the existing Pb-exposed DCs had significantly greater MHC-II expression than did the non-Pb-exposed DCs. However, these differences diminished upon LPS stimulation. After LPS stimulation, CD80, CD86, CD40, CD54, and MHC-II were all up-regulated on both Pb-DCs and DCs, but Pb-DCs expressed significantly less CD80 than did DCs. The CD86:CD80 ratio suggests a Pb-DC potential for Th2 cell development. After LPS stimulation, IL-6, IL-10, IL-12 (p70), and TNF-α levels significantly increased with both Pb-DCs and DCs, but Pb-DCs produced significantly less cytokines than did DCs, except for IL-10, which further supports Pb-DC preferential skewing toward type-2 immunity. In vitro studies confirm that Pb-DCs have the ability to polarize antigen-specific T cells to Th2 cells. Pb-DCs also enhanced allogeneic and autologous T cell proliferation in vitro, and in vivo studies suggested that Pb-DCs inhibited Th1 effects on humoral and cell-mediated immunity. The Pb effect was mainly on DCs, rather than on T cells, and Pb's modification of DC function appears to be the main cause of Pb's promotion of type-2-related immunity, which may relate to Pb's enhanced activation of the Erk/MAP kinase pathway

Deposition of lead and cadmium released by cigarette smoke in dental structures and resin composite.

Science.gov (United States)

Takeuchi, Cristina Yoshie Garcia; Corrêa-Afonso, Alessandra Marques; Pedrazzi, Hamilton; Dinelli, Welingtom; Palma-Dibb, Regina Guenka

2011-03-01

Cigarette smoke is a significant source of cadmium, lead, and toxic elements, which are absorbed into the human organism. In this context, the aim of this study was to investigate in vitro the presence of toxic elements, cadmium, and lead deriving from cigarette smoke in the resin composite, dentine, and dental enamel. Eight cylindrical specimens were fabricated from resin composite, bovine enamel, and root dentin fragments that were wet ground and polished with abrasive paper to obtain sections with 6-mm diameter and 2-mm thickness. All specimens were exposed to the smoke of 10 cigarettes/day during 8 days. After the simulation of the cigarette smoke, the specimens were examined with scanning electron microscopy (SEM) and the energy-dispersive X-ray analysis. In the photomicrographic analysis in SEM, no morphological alterations were found; however, the microanalysis identified the presence of cadmium, arsenic, and lead in the different specimens. These findings suggest that the deposition of these elements derived from cigarette smoke could be favored by dental structures and resin composite. Copyright © 2010 Wiley-Liss, Inc.

Geological and Geochemical Characteristics of Skarn Type Lead-Zinc Deposit in Baoshan Block, Yunnan Province

Science.gov (United States)

Yao, Xue; Wang, Peng

2017-11-01

Baoshan block is an important Pb-Zn-Fe-Cu polymetallic ore-concentration area which is located in southern of the Sanjiang metallogenic belt in western Yunnan. The article is studying about the geological and geochemical characteristics of the skarn type lead-zinc deposit in Baoshan block. The skarn-type lead-zinc deposit Baoshan block is characterized by skarn and skarn marble, and the orebodies are layered, or bedded along the interlayer fault, which are significantly controlled by structure. The research about Stable isotope S, H and O indicates that the ore-forming fluids are mainly derived from magmatic water, partly mixed with parts of metamorphic water and atmospheric precipitation. The initial Sr isotopic Sr87/Sr86 ratio suggests that the ore-forming materials derived from deep concealed magmatic rock, age of Rb-Sr mineralization is similar to that of Yanshanian granite. In conclusion, the Yanshanian tectonic-magmatic-fluid coupling mineralization of Yanshan formation is the main reason for the skarn-type lead-zinc deposit in the Baoshan block.

Naturally Occurring Cinnamic Acid Sugar Ester Derivatives

Directory of Open Access Journals (Sweden)

Yuxin Tian

2016-10-01

Full Text Available Cinnamic acid sugar ester derivatives (CASEDs are a class of natural product with one or several phenylacrylic moieties linked with the non-anomeric carbon of a glycosyl skeleton part through ester bonds. Their notable anti-depressant and brains protective activities have made them a topic of great interest over the past several decades. In particular the compound 3′,6-disinapoylsucrose, the index component of Yuanzhi (a well-known Traditional Chinese Medicine or TCM, presents antidepressant effects at a molecular level, and has become a hotspot of research on new lead drug compounds. Several other similar cinnamic acid sugar ester derivatives are reported in traditional medicine as compounds to calm the nerves and display anti-depression and neuroprotective activity. Interestingly, more than one third of CASEDs are distributed in the family Polygalaceae. This overview discusses the isolation of cinnamic acid sugar ester derivatives from plants, together with a systematic discussion of their distribution, chemical structures and properties and pharmacological activities, with the hope of providing references for natural product researchers and draw attention to these interesting compounds.

75 FR 52512 - Acceptance of Public Submissions on the Wall Street Reform and Consumer Protection Act and the...

Science.gov (United States)

2010-08-26

... and Consumer Protection Act and the Rulemakings That Will Be Proposed by the Commission AGENCY...-Frank Wall Street Reform and Consumer Protection Act (``Dodd-Frank Act'') was enacted on July 21, 2010... Consumer Protection Act (``Dodd-Frank Act''), Public Law 111-203, was enacted. The Dodd-Frank Act will...

synthesis and characterization of some poly functionalized heterocyclic derivatives of expected biological activity

International Nuclear Information System (INIS)

El-sayed, M.S.

2001-01-01

The present work was aimed and designed to fulfil The following objectives : 1- Continuation of the effort done by our research group in the field of chemistry of pyridinethione derivatives and their biological activities. 2- Synthesis of several new heterocyclic derivatives containing N and/or S using the laboratory available reagents. 3- Establishment of the structures of the newly synthesized heterocyclic compounds by the data of IR, 1 H-NMR, mass spectra in addition to the elemental analysis. 4- Synthesis of some of these heterocyclic derivatives via alternative routs and this used as a tool to confirm the structures of the newly synthesized heterocyclic derivatives. 5- study of the most probable mechanisms leading to the formation of the new heterocyclic derivatives. 6- The antimicrobial activity of some of the newly synthesized heterocyclic derivatives was tested against several types of organisms

Biosorption of lead phosphates by lead-tolerant bacteria as a mechanism for lead immobilization.

Science.gov (United States)

Rodríguez-Sánchez, Viridiana; Guzmán-Moreno, Jesús; Rodríguez-González, Vicente; Flores-de la Torre, Juan Armando; Ramírez-Santoyo, Rosa María; Vidales-Rodríguez, Luz Elena

2017-08-01

The study of metal-tolerant bacteria is important for bioremediation of contaminated environments and development of green technologies for material synthesis due to their potential to transform toxic metal ions into less toxic compounds by mechanisms such as reduction, oxidation and/or sequestration. In this study, we report the isolation of seven lead-tolerant bacteria from a metal-contaminated site at Zacatecas, México. The bacteria were identified as members of the Staphylococcus and Bacillus genera by microscopic, biochemical and 16S rDNA analyses. Minimal inhibitory concentration of these isolates was established between 4.5 and 7.0 mM of Pb(NO 3 ) 2 in solid and 1.0-4.0 mM of Pb(NO 3 ) 2 in liquid media. A quantitative analysis of the lead associated to bacterial biomass in growing cultures, revealed that the percentage of lead associated to biomass was between 1 and 37% in the PbT isolates. A mechanism of complexation/biosorption of lead ions as inorganic phosphates (lead hydroxyapatite and pyromorphite) in bacterial biomass, was determined by Fourier transform infrared spectroscopy and X-ray diffraction analyses. Thus, the ability of the lead-tolerant isolates to transform lead ions into stable and highly insoluble lead minerals make them potentially useful for immobilization of lead in mining waste.

Derivations and comparisons of three groups of self-organization theories for magnetohydrodynamic plasmas

International Nuclear Information System (INIS)

Kondoh, Yoshiomi; Sato, Tetsuya.

1994-01-01

A theoretical investigation on self-organization theories of dissipative MHD plasmas is presented to derive three groups of theories that lead to the same relaxed state of ∇xB=λB, in order to find more essential physical picture embedded in self-organization phenomena due to nonlinear and dissipative processes. Comparisons among all of the theories treated and derived here suggest that a theory standing upon spectrum spreadings and selective dissipations of eigenmodes for the dissipative operator-∇xηj and leading to self-organized relaxed states of ∇xηj=αB/2 with the minimum dissipation rate is the most agreeable to various results obtained by experiments and by 3-D MHD simulations reported so far. (author)

Effects of lead and mercury on histamine uptake by glial and endothelial cells

Energy Technology Data Exchange (ETDEWEB)

Huszti, Z. [Semmelweis Univ. of Medicine, Dept. of Pharmacodynamics, Budapest (Hungary); Balogh, I. [Semmelweis Univ. of Medicine, Forensic Medicine, Budapest (Hungary)

1995-06-01

The effects of lead and mercury on [{sup 3}H]-histamine uptake by cultured astroglial and endothelial cells of rat brain were studied. Experimental data showed that both metal ions inhibited the uptake in both cell types of concentrations as low as 1-10 {mu}M. The effects were consistent with non/competitive inhibitions. With either lead or mercury exposure, the inhibition of the uptake was greater in astroglial than in cerebral endothelial cells. Contrary to the above finding, 100 {mu}M of mercuric chloride produced stimulation of histamine uptake and this stimulation was much more pronounced in cultured cerebral endothelial cells than in astroglial cells. Inhibition of [{sup 3}H]-histamine uptake by lead acetate and mercuric chloride was considered to be association with a loss of the transmembrane Na{sup +} and/or K{sup +} gradient while stimulation of the uptake by high concentration of mercury might be related to a direct effect on histamine transporter. It is note-worthy, that cultured astroglial cells, derived from neonatal rat brain, are much more sensitive to the toxic effects of these heavy metal ions than cultured endothelial cells derived from the brain capillaries often same species of animals. (au) 18 refs.

Hamiltonian derivation of a gyrofluid model for collisionless magnetic reconnection

International Nuclear Information System (INIS)

Tassi, E

2014-01-01

We consider a simple electromagnetic gyrokinetic model for collisionless plasmas and show that it possesses a Hamiltonian structure. Subsequently, from this model we derive a two-moment gyrofluid model by means of a procedure which guarantees that the resulting gyrofluid model is also Hamiltonian. The first step in the derivation consists of imposing a generic fluid closure in the Poisson bracket of the gyrokinetic model, after expressing such bracket in terms of the gyrofluid moments. The constraint of the Jacobi identity, which every Poisson bracket has to satisfy, selects then what closures can lead to a Hamiltonian gyrofluid system. For the case at hand, it turns out that the only closures (not involving integro/differential operators or an explicit dependence on the spatial coordinates) that lead to a valid Poisson bracket are those for which the second order parallel moment, independently for each species, is proportional to the zero order moment. In particular, if one chooses an isothermal closure based on the equilibrium temperatures and derives accordingly the Hamiltonian of the system from the Hamiltonian of the parent gyrokinetic model, one recovers a known Hamiltonian gyrofluid model for collisionless reconnection. The proposed procedure, in addition to yield a gyrofluid model which automatically conserves the total energy, provides also, through the resulting Poisson bracket, a way to derive further conservation laws of the gyrofluid model, associated with the so called Casimir invariants. We show that a relation exists between Casimir invariants of the gyrofluid model and those of the gyrokinetic parent model. The application of such Hamiltonian derivation procedure to this two-moment gyrofluid model is a first step toward its application to more realistic, higher-order fluid or gyrofluid models for tokamaks. It also extends to the electromagnetic gyrokinetic case, recent applications of the same procedure to Vlasov and drift- kinetic systems

Derivative self-interactions for a massive vector field

Energy Technology Data Exchange (ETDEWEB)

Beltrán Jiménez, Jose, E-mail: jose.beltran@cpt.univ-mrs.fr [CPT, Aix Marseille Université, UMR 7332, 13288 Marseille (France); Heisenberg, Lavinia, E-mail: lavinia.heisenberg@eth-its.ethz.ch [Institute for Theoretical Studies, ETH Zurich, Clausiusstrasse 47, 8092 Zurich (Switzerland)

2016-06-10

In this work we revisit the construction of theories for a massive vector field with derivative self-interactions such that only the 3 desired polarizations corresponding to a Proca field propagate. We start from the decoupling limit by constructing healthy interactions containing second derivatives of the Stueckelberg field with itself and also with the transverse modes. The resulting interactions can then be straightforwardly generalized beyond the decoupling limit. We then proceed to a systematic construction of the interactions by using the Levi–Civita tensors. Both approaches lead to a finite family of allowed derivative self-interactions for the Proca field. This construction allows us to show that some higher order terms recently introduced as new interactions trivialize in 4 dimensions by virtue of the Cayley–Hamilton theorem. Moreover, we discuss how the resulting derivative interactions can be written in a compact determinantal form, which can also be regarded as a generalization of the Born-Infeld lagrangian for electromagnetism. Finally, we generalize our results for a curved background and give the necessary non-minimal couplings guaranteeing that no additional polarizations propagate even in the presence of gravity.

Intermediate-range order in lead metasilicate glass

Energy Technology Data Exchange (ETDEWEB)

Suzuya, Kentaro [Japan Atomic Energy Research Inst., Ako, Hyogo (Japan)]|[Argonne National Lab., IL (United States). Materials Science Div.; Price, D.L.; Saboungi, M.L. [Argonne National Lab., IL (United States). Materials Science Div.; Ohno, Hideo [Japan Atomic Energy Research Inst., Ako, Hyogo (Japan)

1997-03-01

The complementarity of anomalous X-ray scattering (AXS) and neutron diffraction (ND) techniques is used here to investigate the nature and origin of intermediate-range order in lead metasilicate glass. Both X-ray and neutron source factors reveal small peaks at low wave vector which are shown to be associated with intermediate-range order of the Pb-O network. The combination of AXS and ND is shown to be a powerful tool to correlate contributions from the different atom pairs to such a peak. The information thus derived is compared with results from alkali germanate glasses and with structural data on corresponding crystalline compounds.

Contribution of lead and thorium to the history of the Oklo reactors

International Nuclear Information System (INIS)

Devillers, C.; Menes, J.

1978-01-01

The authors report the results of measuring lead and thorium in a series of representative samples of the superconcentrations of uranium found in the Oklo mineralization. Interpretation of the data reveals the complexity of the history of lead in the deposit, but makes it possible to derive a number of important facts, namely early disturbance and recent, massive remobilization of lead. One is led to conclude that the date of the uranium emplacement may be greater than 1900 million years. The absence of high thorium contents in the ''normal'' rich ore confirms the importance of dating the nuclear reaction on the basis of the Th/U balance. This determination, which draws on the same set of data as for the Nd/U balance, gives a mean value close to 1930 million years. (author)

Synthesis and Biological Evaluation of Novel Jatrorrhizine Derivatives with Amino Groups Linked at the 3-Position as Inhibitors of Acetylcholinesterase

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Xiaofei Jiang

2017-01-01

Full Text Available Jatrorrhizine was considered as one of the active constituents of Coptis chinensis Franch. Herein, jatrorrhizine derivatives with substituted amino groups linked at the 3-position were designed, synthesized, and biologically evaluated as inhibitors of acetylcholinesterase. Jatrorrhizine derivatives inhibited the activity of acetylcholinesterase (AChE to a greater extent than the lead compound jatrorrhizine. All these jatrorrhizine derivatives were proved to be potent inhibitors of acetylcholinesterase (AChE with submicromolar IC50 values, but less sensitive to butyrylcholinesterase (BuChE, which suggests that these jatrorrhizine derivatives are selective for AChE/BuChE. Compound 3g gave the most potent inhibitor activity for AChE (IC50 = 0.301 μM, which is greater than the lead compound jatrorrhizine. All these results demonstrated that these jatrorrhizine derivatives are potential inhibitors for AChE.

Next-to-leading-logarithmic power corrections for N -jettiness subtraction in color-singlet production

Science.gov (United States)

Boughezal, Radja; Isgrò, Andrea; Petriello, Frank

2018-04-01

We present a detailed derivation of the power corrections to the factorization theorem for the 0-jettiness event shape variable T . Our calculation is performed directly in QCD without using the formalism of effective field theory. We analytically calculate the next-to-leading logarithmic power corrections for small T at next-to-leading order in the strong coupling constant, extending previous computations which obtained only the leading-logarithmic power corrections. We address a discrepancy in the literature between results for the leading-logarithmic power corrections to a particular definition of 0-jettiness. We present a numerical study of the power corrections in the context of their application to the N -jettiness subtraction method for higher-order calculations, using gluon-fusion Higgs production as an example. The inclusion of the next-to-leading-logarithmic power corrections further improves the numerical efficiency of the approach beyond the improvement obtained from the leading-logarithmic power corrections.

Does a concomitant exposure to lead influence unfavorably the naphthalene subchronic toxicity and toxicokinetics?

Science.gov (United States)

Katsnelson, Boris A; Minigaliyeva, Ilzira A; Degtyareva, Tamara D; Privalova, Larisa I; Beresneva, Tatyana A

2014-01-01

Rats were given 20 times during 40 d either naphthalene per gavage or the same and lead acetate intraperitoneally in single doses corresponding to 5% of the respective 50% lethal doses. The concomitant exposure to lead not only added some typical indicators of lead toxicity to the moderate naphthalene intoxication picture but also exaggerated some less specific indices for intoxication. However, a number of such indices testified to attenuation of naphthalene's adverse effects under the impact of lead. Lead also lowered urinary excretion of both total and conjugated naphthalene, while the free- to total naphthalene ratio in urine sharply increased. These results corroborate implicitly the initial hypothesis that lead, being an inhibitor of cytochrome P450, hinders phase I of the naphthalene biotransformation and, thus, the formation of derivates which can be more toxic but are capable of entering into reactions of conjugation with resulting detoxication and elimination of naphthalene from the body. © 2013 SETAC.

Alternative derivations of the statistical mechanical distribution laws.

Science.gov (United States)

Wall, F T

1971-08-01

A new approach is presented for the derivation of statistical mechanical distribution laws. The derivations are accomplished by minimizing the Helmholtz free energy under constant temperature and volume, instead of maximizing the entropy under constant energy and volume. An alternative method involves stipulating equality of chemical potential, or equality of activity, for particles in different energy levels. This approach leads to a general statement of distribution laws applicable to all systems for which thermodynamic probabilities can be written. The methods also avoid use of the calculus of variations, Lagrangian multipliers, and Stirling's approximation for the factorial. The results are applied specifically to Boltzmann, Fermi-Dirac, and Bose-Einstein statistics. The special significance of chemical potential and activity is discussed for microscopic systems.

A novel mechanism of bacterial toxin transfer within host blood cell-derived microvesicles.

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Anne-lie Ståhl

2015-02-01

Full Text Available Shiga toxin (Stx is the main virulence factor of enterohemorrhagic Escherichia coli, which are non-invasive strains that can lead to hemolytic uremic syndrome (HUS, associated with renal failure and death. Although bacteremia does not occur, bacterial virulence factors gain access to the circulation and are thereafter presumed to cause target organ damage. Stx was previously shown to circulate bound to blood cells but the mechanism by which it would potentially transfer to target organ cells has not been elucidated. Here we show that blood cell-derived microvesicles, shed during HUS, contain Stx and are found within patient renal cortical cells. The finding was reproduced in mice infected with Stx-producing Escherichia coli exhibiting Stx-containing blood cell-derived microvesicles in the circulation that reached the kidney where they were transferred into glomerular and peritubular capillary endothelial cells and further through their basement membranes followed by podocytes and tubular epithelial cells, respectively. In vitro studies demonstrated that blood cell-derived microvesicles containing Stx undergo endocytosis in glomerular endothelial cells leading to cell death secondary to inhibited protein synthesis. This study demonstrates a novel virulence mechanism whereby bacterial toxin is transferred within host blood cell-derived microvesicles in which it may evade the host immune system.

Stress proteins and oxidative damage in a renal derived cell line exposed to inorganic mercury and lead

International Nuclear Information System (INIS)

Stacchiotti, Alessandra; Morandini, Fausta; Bettoni, Francesca; Schena, Ilaria; Lavazza, Antonio; Grigolato, Pier Giovanni; Apostoli, Pietro; Rezzani, Rita; Aleo, Maria Francesca

2009-01-01

A close link between stress protein up-regulation and oxidative damage may provide a novel therapeutic tool to counteract nephrotoxicity induced by toxic metals in the human population, mainly in children, of industrialized countries. Here we analysed the time course of the expression of several heat shock proteins, glucose-regulated proteins and metallothioneins in a rat proximal tubular cell line (NRK-52E) exposed to subcytotoxic doses of inorganic mercury and lead. Concomitantly, we used morphological and biochemical methods to evaluate metal-induced cytotoxicity and oxidative damage. In particular, as biochemical indicators of oxidative stress we detected reactive oxygen species (ROS) and nitrogen species (RNS), total glutathione (GSH) and glutathione-S-transferase (GST) activity. Our results clearly demonstrated that mercury increases ROS and RNS levels and the expressions of Hsp25 and inducible Hsp72. These findings are corroborated by evident mitochondrial damage, apoptosis or necrosis. By contrast, lead is unable to up-regulate Hsp72 but enhances Grp78 and activates nuclear Hsp25 translocation. Furthermore, lead causes endoplasmic reticulum (ER) stress, vacuolation and nucleolar segregation. Lastly, both metals stimulate the over-expression of MTs, but with a different time course. In conclusion, in NRK-52E cell line the stress response is an early and metal-induced event that correlates well with the direct oxidative damage induced by mercury. Indeed, different chaperones are involved in the specific nephrotoxic mechanism of these environmental pollutants and work together for cell survival.

The derivative expansion of the fermion number current

International Nuclear Information System (INIS)

D'Hoker, E.; Goldstone, J.

1985-01-01

The fermion number current is evaluated to leading order in the derivative expansion for chiral fermions in the background of arbitrary Higgs and chiral gauge fields. This current is given by the gauged topological current plus a total divergence term. The total divergence term is absent in Weinberg-Salam theory with one scalar Higgs doublet, even for an arbitrary mass matrix, but appears when several Higgs doublets are present. (orig.)

A stable lead isotopic investigation of the use of sycamore tree rings as a historical biomonitor of environmental lead contamination

International Nuclear Information System (INIS)

Patrick, Gavin J.; Farmer, John G.

2006-01-01

The validity of the use of sycamore (Acer pseudoplatanus) tree-rings for the reconstruction of atmospheric lead pollution histories was investigated. Tree cores spanning 1892-2003 were collected from several sycamores from the eastern shore of Loch Lomond, Scotland, an area with no local point sources of lead emission. The lead concentration and 206 Pb/ 207 Pb profiles of the Loch Lomond region cores were compared with corresponding data for the 21 Pb-dated loch sediment, and also with data for moss of known age from a Scottish herbarium collection. Two of the seven sycamore cores showed the same lead concentration trend as the lead flux to the loch, the rest having no similarity to either each other or the loch sediment record. Two further sycamore cores showed some similarity in their temporal 206 Pb/ 207 Pb trends to those seen in the sediment and moss records, but only in part of their profiles, whilst the 206 Pb/ 207 Pb ratios of the other sycamore cores remained relatively unchanged for the majority of the time covered, or exhibited an opposite trend. The 206 Pb/ 207 Pb ratios of the tree cores were also mostly higher than those of the previously established records for any given time period. Tree cores covering 1878-2002 were also collected along transects from Wanlockhead and Tyndrum, two areas of former lead mining and smelting associated with distinct 206 Pb/ 207 Pb ratios of 1.170 and 1.144, respectively. The Wanlockhead tree cores exhibited a generally decreasing trend in lead concentration with both time and distance from the lead mine. The characteristic 206 Pb/ 207 Pb ratio of 1.170 was observed in samples close to the mine but a decrease in the influence of the mine-derived lead was observed in more distant samples. The tree sampled at Tyndrum showed elevated lead concentrations, which decreased with time, and a fairly constant 206 Pb/ 207 Pb ratio of ∼ 1.15 reflecting input from the mine, features not observed in any other trees along the

Effects of lead-contaminated sediment and nutrition on mallard duckling brain growth and biochemistry

International Nuclear Information System (INIS)

Douglas-Stroebel, E.; Hoffman, D.J.; Brewer, G.L.; Sileo, L.

2004-01-01

Day-old mallard (Anas platyryhnchos) ducklings received either a clean sediment (24%) supplemented control diet, Coeur d'Alene River Basin, Idaho (CDARB) sediment (3449 μg/g lead) supplemented diets at 12% or 24%, or a positive control diet (24% clean sediment with equivalent lead acetate to the 24% CDARB diet) for 6 weeks. The 12% CDARB diet resulted in a geometric mean concentration of 396 ppb (WW) brain lead with decreased brain protein and ATP concentrations but increased oxidized glutathione (GSSG) relative to the control diet. The 24% CDARB diet resulted in a concentration of 485 ppb brain lead with lower brain weight and ATP concentration than controls but higher concentrations of reduced glutathione (GSH) and calcium. Lead acetate accumulated twice as well as CDARB derived lead and resulted in histopathological lesions of the brain. With a combination of a suboptimal diet and 24% CDARB, brain lead concentration was higher (594 ppb) than with 24% CDARB in the standard diet, histopathological lesions became apparent and GSH was higher than suboptimal diet controls

Role of bone marrow-derived stem cells, renal progenitor cells and ...

African Journals Online (AJOL)

It remains the leading cause of late allograft loss. Bone marrow derived stem cells are undifferentiated cells typically characterized by their capacity for self renewal, ability to give rise to multiple differentiated cellular population, including hematopoietic (HSCs) and mesenchymal stem cells (MSCs). Characterization of HSCs ...

Particle production after inflation with non-minimal derivative coupling to gravity

International Nuclear Information System (INIS)

Ema, Yohei; Jinno, Ryusuke; Nakayama, Kazunori; Mukaida, Kyohei

2015-01-01

We study cosmological evolution after inflation in models with non-minimal derivative coupling to gravity. The background dynamics is solved and particle production associated with rapidly oscillating Hubble parameter is studied in detail. In addition, production of gravitons through the non-minimal derivative coupling with the inflaton is studied. We also find that the sound speed squared of the scalar perturbation oscillates between positive and negative values when the non-minimal derivative coupling dominates over the minimal kinetic term. This may lead to an instability of this model. We point out that the particle production rates are the same as those in the Einstein gravity with the minimal kinetic term, if we require the sound speed squared is positive definite

Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives

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Zhibin Li

2015-07-01

Full Text Available A series of β-Carboline derivatives were designed, synthesized, and evaluated for their fungicidal activities in this study. Several derivatives electively exhibited fungicidal activities against some fungi. Especially, compound F5 exhibited higher fungicidal activity against Rhizoctonia solani (53.35% than commercial antiviral agent validamycin (36.4%; compound F16 exhibited high fungicidal activity against Oospora citriaurantii ex Persoon (43.28%. Some of the alkaloids and their derivatives (compounds F4 and F25 exhibited broad-spectrum fungicidal activity. Specifically, compound F4 exhibited excellent high broad-spectrum fungicidal activity in vitro, and the curative and protection activities against P. litchi in vivo reached 92.59% and 59.26%, respectively. The new derivative, F4, with optimized physicochemical properties, obviously exhibited higher activities both in vitro and in vivo; therefore, F4 may be used as a new lead structure for the development of fungicidal drugs.

Synthesis and complex forming property of phosphor acid derivatives

International Nuclear Information System (INIS)

Babaev, B.N.

2004-01-01

medium of HCl better and ions of silver from medium H 2 SO 4 . 3) If we complicate the structure of heterocyclic amine it can have positive influence to extraction of silver as the result of transition from morpholine to salsolidyn we can achieve the rise of effectiveness the extraction 2-5 times, but the branching of O-alkyl link between phosphoric parts and remains of hetero atom leads to the reduction of extraction effectiveness 2-5 times. Analyses of metal's extraction from technological solutions show that effective phosphor organic extra gents are: a) Lengthening of O-alkyl radicals in compounds molecule leads to the rise of effective extraction so Au as Ag. b) By the method of variation the length of O-alkyl and structure of main radical of phosphor acid derivatives we can derive ions of gold from silver. c) There are such compounds, which extract ions of Pt, Os, Au, and Ag from technological solution effectively. We worked out methods of defining the contest of metals in factory sewage

An experimentally derived magnetic moment for the f7/2 proton in trans-lead nuclei

International Nuclear Information System (INIS)

Stuchbery, A.E.; Byrne, A.P.; Dracoulis, G.D.

1992-12-01

An experimental value for the g-factor of the 1f 7/2 proton is derived from the measured magnetic moment of the 14 + 1 state in 214 Ra using the multiparticle octupole coupling model. The result, g(f 7/2 ) = 1.41(2), is smaller than anticipated by theories which assume first order core polarization corrections to the proton spin g-factor together with an anomalous orbital magnetism of about 0.12. The experimental value suggests the proton spin g-factor g s may be quenched, in this orbital, to about half the bare-nucleon value, similar to that found for the 0h 9/2 and 0i 13/2 protons, or, alternatively, that the anomalous orbital magnetism is much reduced for the 1f 7/2 orbital. 15 refs., 2 tabs

First detection of lead in black paper from intraoral film

International Nuclear Information System (INIS)

Guedes, Debora F.C.; Silva, Reginaldo S.; Veiga, Marcia A.M.S. da; Pecora, Jesus D.

2009-01-01

Lead (Pb) contamination in the black paper that recovers intraoral films (BKP) has been investigated. BKP samples were collected from the Radiology Clinics of the Dental School of Ribeirao Preto, University of Sao Paulo, Brazil. For sake of comparison, four different methods were used. The results revealed the presence of high lead levels, well above the maximum limit allowed by the legislation. Pb contamination levels achieved after the following treatments: paper digestion in nitric acid, microwave treatment, DIN38414-54 method and TCLP method were 997 μg g -1 , 189 μg g -1 , 20.8 μg g -1 , and 54.0 μg g -1 , respectively. Flame atomic absorption spectrometry (FAAS) and inductively coupled plasma mass spectrometry (ICP-MS) were employed for lead determination according to the protocols of the applied methods. Lead contamination in used BKP was confirmed by scanning electron microscopy coupled with energy dispersive X-ray microanalysis (SEM-EDS). All the SEM imaging was carried out in the secondary electron mode (SE) and backscattered-electron mode (QBSD) following punctual X-ray fluorescence spectra. Soil contamination derived from this product revealed the urgent need of addressing this problem. These elevated Pb levels, show that a preliminary treatment of BKP is mandatory before it is disposed into the common trash. The high lead content of this material makes its direct dumping into the environment unwise.

Distribution and Variability of Satellite-Derived Signals of Isolated Convection Initiation Events Over Central Eastern China

Science.gov (United States)

Huang, Yipeng; Meng, Zhiyong; Li, Jing; Li, Wanbiao; Bai, Lanqiang; Zhang, Murong; Wang, Xi

2017-11-01

This study combined measurements from the Chinese operational geostationary satellite Fengyun-2E (FY-2E) and ground-based weather radars to conduct a statistical survey of isolated convection initiation (CI) over central eastern China (CEC). The convective environment in CEC is modulated by the complex topography and monsoon climate. From May to August 2010, a total of 1,630 isolated CI signals were derived from FY-2E using a semiautomated method. The formation of these satellite-derived CI signals peaks in the early afternoon and occurs with high frequency in areas with remarkable terrain inhomogeneity (e.g., mountain, water, and mountain-water areas). The high signal frequency areas shift from northwest CEC (dry, high altitude) in early summer to southeast CEC (humid, low altitude) in midsummer along with an increasing monthly mean frequency. The satellite-derived CI signals tend to have longer lead times (the time difference between satellite-derived signal formation and radar-based CI) in the late morning and afternoon than in the early morning and night. During the early morning and night, the distinction between cloud top signatures and background terrestrial radiation becomes less apparent, resulting in delayed identification of the signals and thus short and even negative lead times. A decline in the lead time is observed from May to August, likely due to the increasing cloud growth rate and warm-rain processes. Results show increasing lead times with increasing landscape elevation, likely due to more warm-rain processes over the coastal sea and plain, along with a decreasing cloud growth rate from hill and mountain to the plateau.

Synthesis and Insecticidal Activities of New Ester-Derivatives of Celangulin-V

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Wenjun Wu

2011-12-01

Full Text Available In order to develop new biorational pesticides, ten new 6-substituted ester derivatives of Celangulin-V were designed and synthesized. The structures of the new derivatives were confirmed by IR, 1H-NMR, 13C-NMR and ESI-MS spectral analysis. Insecticidal activities of these compounds were tested against the third-instar larvae of Mythimna separata. Two derivatives (1.1, 1.2 showed higher insecticidal activities than Celangulin-V, with mortality of 75.0% and 83.3%, respectively. While four compounds (1.3, 1.4, 1.7, 1.8 denoted lower insecticidal activities, the others (1.5, 1.6, 1.9, 1.10 revealed no activities at a concentration of 10 mg.mL−1. The results suggest that C-6 substitutions of Celangulin-V are very important in determining the insecticidal activities of its ester-derivatives. That the acetyl (1.1 and propionyl (1.2 derivatives possessed much higher insecticidal activities than Celangulin-V itself supported the view that Celangulin-V has the potential to be a lead structure of semi-synthetic green insecticides.

Lead isotopes as an environmental indicator of pollution sources

International Nuclear Information System (INIS)

Aaberg, G.; Pacyna, J.; Stray, H.

1997-02-01

An interesting question when determining and quantifying pollution is the characterisation of the sources. Also, is the pollution locally derived or is it longtransported? Analyses of Pb isotope ratios and Pb concentrations on airfilter from Oslo, Norway, together with analyses of coal of different origin and wood, show that the decrease in total Pb in the first half of the 1990's is not due only to the reduction of leaded petrol but that there are other important sources for the pollution which have been cut down. The reduction in emissions from coal burning in Europe can be seen on airfilter from Oslo and also the following reduction in leaded petrol. An isotopic study of lead on airfilter from the countryside outside Oslo implies that the finer particles have been atmospherically long transported while the coarser particles are of a more local origin, e.g. from domestic burning of wood. The above results show that the use of a natural isotopic system like Pb is a powerful tool for e.g. the determination of pollution, routes of its transportation, for the monitoring of processes of the present, and for provenance determinations. 7 refs., 8 figs., 2 tabs

Lead and lead-based alloys as waste matrix materials

International Nuclear Information System (INIS)

Arustamov, A.E.; Ojovan, M.I.; Kachalov, M.B.

1999-01-01

Metals and alloys with relatively low melting temperatures such as lead and lead-based alloys are considered in Russia as prospective matrices for encapsulation of spent nuclear fuel in containers in preparation for final disposal in underground repositories. Now lead and lead-based alloys are being used for conditioning spent sealed radioactive sources at radioactive waste disposal facilities

Lead poisoning

Science.gov (United States)

... drinking water in homes containing pipes that were connected with lead solder . Although new building codes require ... lead in their bodies when they put lead objects in their mouths, especially if they swallow those ...

Fractional derivatives for physicists and engineers background and theory

CERN Document Server

Uchaikin, Vladimir V

2013-01-01

The first derivative of a particle coordinate means its velocity, the second means its acceleration, but what does a fractional order derivative mean? Where does it come from, how does it work, where does it lead to? The two-volume book written on high didactic level answers these questions. Fractional Derivatives for Physicists and Engineers— The first volume contains a clear introduction into such a modern branch of analysis as the fractional calculus. The second develops a wide panorama of applications of the fractional calculus to various physical problems. This book recovers new perspectives in front of the reader dealing with turbulence and semiconductors, plasma and thermodynamics, mechanics and quantum optics, nanophysics and astrophysics.  The book is addressed to students, engineers and physicists, specialists in theory of probability and statistics, in mathematical modeling and numerical simulations, to everybody who doesn't wish to stay apart from the new mathematical methods becoming more and ...

Calculation of Quantitative Structure-Activity Relationship Descriptors of Artemisinin Derivatives

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Jambalsuren Bayarmaa

2008-06-01

Full Text Available Quantitative structure-activity relationships are based on the construction of predictive models using a set of known molecules and associated activity value. This accurate methodology, developed with adequate mathematical and computational tools, leads to a faster, cheaper and more comprehensive design of new products, reducing the experimental synthesis and testing on animals. Preparation of the QSAR models of artemisinin derivatives was carried out by the genetic function algorithm (GFA method for 91 molecules. The results show some relationships to the observed antimalarial activities of the artemisinin derivatives. The most statistically signi fi cant regression equation obtained from the fi nal GFA relates to two molecular descriptors.

Delayed visual maturation is not from lead pollution

International Nuclear Information System (INIS)

Gulson, B.L.; Howarth, D.

2000-01-01

radioactive decay, the amounts (abundances) have changed over geological time and this is reflected in the geological source of the lead. The abundances are usually expressed as ratios. Lead from the geologically old (∼1700 million years old) lead-zinc-silver deposits of Broken Hill in NSW has an 206 Pb/ 204 Pb abundance ratio of 16.00 whereas the ratio is 18.1-18.3 for geologically young deposits, 500-400 million years old, on the same continent or from the northern hemisphere. It is these isotopic differences that are used to evaluate the source of lead in the environment, humans and animals. Interpretations of lead isotopic data may not be straightforward because lead in the environment or animals may be a mixture of lead from different sources (mines). Hence, lead that is introduced to the body from air/food/water is largely dependent on the source of lead in the environment, which in turn is dependent on the age and hence isotopic composition of the rocks/ores from which the lead in the environment is derived

Adenocarcinoma of the stomach following radical radiotherapy for testicular cancer

International Nuclear Information System (INIS)

Griffith, C.D.M.; Chadderton, R.; Bourke, J.B.

1990-01-01

Two male patients who underwent curative surgery and adjuvant radiotherapy (with further chemotherapy in one) for testicular cancer developed adenocarcinoma of the stomach 5 and 19 years after treatment. The stomach is included in the field of radiotherapy used to treat the para-aortic lymph nodes and this may lead to dysplastic changes in the stomach mucosa which can lead to frank malignancy. Early endoscopy should be offered to patients with dyspeptic symptoms after adjuvant radiotherapy for testicular cancer. (author)

Lead Poisoning

Science.gov (United States)

Lead is a metal that occurs naturally in the earth's crust. Lead can be found in all parts of our ... from human activities such as mining and manufacturing. Lead used to be in paint; older houses may ...

Agrobacterium tumefaciens responses to plant-derived signaling molecules

Science.gov (United States)

Subramoni, Sujatha; Nathoo, Naeem; Klimov, Eugene; Yuan, Ze-Chun

2014-01-01

As a special phytopathogen, Agrobacterium tumefaciens infects a wide range of plant hosts and causes plant tumors also known as crown galls. The complexity of Agrobacterium–plant interaction has been studied for several decades. Agrobacterium pathogenicity is largely attributed to its evolved capabilities of precise recognition and response to plant-derived chemical signals. Agrobacterium perceives plant-derived signals to activate its virulence genes, which are responsible for transferring and integrating its Transferred DNA (T-DNA) from its Tumor-inducing (Ti) plasmid into the plant nucleus. The expression of T-DNA in plant hosts leads to the production of a large amount of indole-3-acetic acid (IAA), cytokinin (CK), and opines. IAA and CK stimulate plant growth, resulting in tumor formation. Agrobacterium utilizes opines as nutrient sources as well as signals in order to activate its quorum sensing (QS) to further promote virulence and opine metabolism. Intriguingly, Agrobacterium also recognizes plant-derived signals including γ-amino butyric acid and salicylic acid (SA) to activate quorum quenching that reduces the level of QS signals, thereby avoiding the elicitation of plant defense and preserving energy. In addition, Agrobacterium hijacks plant-derived signals including SA, IAA, and ethylene to down-regulate its virulence genes located on the Ti plasmid. Moreover, certain metabolites from corn (Zea mays) also inhibit the expression of Agrobacterium virulence genes. Here we outline the responses of Agrobacterium to major plant-derived signals that impact Agrobacterium–plant interactions. PMID:25071805

Agrobacterium tumefaciens responses to plant-derived signaling molecules

Directory of Open Access Journals (Sweden)

Sujatha eSubramoni

2014-07-01

Full Text Available As a special phytopathogen, Agrobacterium tumefaciens infects a wide range of plant hosts and causes plant tumors also known as crown galls. The complexity of Agrobacterium-plant interaction has been studied for several decades. Agrobacterium pathogenicity is largely attributed to its evolved capabilities of precise recognition and response to plant-derived chemical signals. Agrobacterium perceives plant-derived signals to activate its virulence genes, which are responsible for transferring and integrating its T-DNA (Transferred DNA from its Tumour-inducing (Ti plasmid into the plant nucleus. The expression of T-DNA in plant hosts leads to the production of a large amount of indole-3-acetic acid (IAA, cytokinin (CK and opines. IAA and CK stimulate plant growth, resulting in tumor formation. Agrobacterium utilizes opines as nutrient sources as well as signals in order to activate its quorum sensing (QS to further promote virulence and opine metabolism. Intriguingly, Agrobacterium also recognizes plant-derived signals including -amino butyric acid (GABA and salicylic acid (SA to activate quorum quenching that reduces the level of QS signals, thereby avoiding the elicitation of plant defense and preserving energy. In addition, Agrobacterium hijacks plant-derived signals including SA, IAA, and ethylene (ET to down-regulate its virulence genes located on the Ti plasmid. Moreover, certain metabolites from corn (Zea mays also inhibit the expression of Agrobacterium virulence genes. Here we outline the responses of Agrobacterium to major plant-derived signals that impact Agrobacterium-plant interactions.

Deriving GENERIC from a Generalized Fluctuation Symmetry

Science.gov (United States)

Kraaij, Richard; Lazarescu, Alexandre; Maes, Christian; Peletier, Mark

2018-02-01

Much of the structure of macroscopic evolution equations for relaxation to equilibrium can be derived from symmetries in the dynamical fluctuations around the most typical trajectory. For example, detailed balance as expressed in terms of the Lagrangian for the path-space action leads to gradient zero-cost flow. We expose a new such fluctuation symmetry that implies GENERIC, an extension of gradient flow where a Hamiltonian part is added to the dissipative term in such a way as to retain the free energy as Lyapunov function.

Drosophila subobscura flies adapted to low lead concentration carry no fitness cost

International Nuclear Information System (INIS)

Kalajdzic, Predrag; Kenig, Bojan; Andjelkovic, Marko

2015-01-01

As a response to the long-term presence of heavy metals in the environment, populations can evolve resistance. Its maintenance may have detrimental effect on population's fitness, causing a fitness cost. Lead is one of the widely distributed elements in the environment exhibiting high toxicity on organisms. By analyzing developmental stages viability and developmental time, we evaluated fitness cost in Drosophila subobscura flies adapted to low lead concentration and control flies derived from the same wild population, as well as their hybrids. Significant changes in specific developmental stages viability were detected in both lines, as well as their hybrids, suggesting complex response to low lead concentration. The results show that a long-term exposure to low lead concentration may have a significant impact on a population's survival, especially in a changing environment conditions. - Highlights: • We analyzed fitness cost in Drosophila subobscura flies reared on lead (Pb) for 37 generations. • Two fitness components, developmental stages viability and developmental time, were analyzed. • A long-term exposure to low lead concentration exhibits a complex adaptation response in D. subobscura flies. • A long-term exposure to low lead concentration decreases viability of population in a changing environment condition. - This study suggests that wild species under a long-term exposure to low concentrations of heavy metals could be in increased risk of population reduction under changing environments

Lead Test

Science.gov (United States)

... to do renovation and repair projects using lead-safe work practices to avoid creating more lead dust or ... in a dangerous area? Yes. If you are working in a potentially harmful environment with exposure to lead dust or fumes: Wash ...

The Boltzmann-Langevin Equation derived from the real-time path formalism

International Nuclear Information System (INIS)

Suraud, E.; Reinhard, P.G.

1991-01-01

We derive the Boltzmann-Langevin equation using Green's functions techniques in the real-time path formalism. We start from the Martin-Schwinger hierarchy and close it approximately at the two-body level. A careful discussion of the initial conditions for the free two-body Green's function provides the flexibility to recover the discarded correlations as fluctuations leading to the Langevin force. The derivation is generalized to the T-matrix approach which allows to prove that one can use the same effective interaction in the mean-field as well as in the collision term and Langevin force

Bulk diffusion and solubility of silver and nickel in lead, lead-silver and lead-nickel solid solutions

International Nuclear Information System (INIS)

Amenzou-Badrour, H.; Moya, G.; Bernardini, J.

1988-01-01

The results of a study of solubility and bulk diffusion of /sup 110/Ag and /sup 63/Ni in lead, lead-silver and lead-nickel solid solutions in the temperature range 220 to 88 0 C are reported. Owing to the low solubility of silver and nickel in lead, Fick's solution corresponding to the boundary condition of a constant concentration of solute at the surface has been used. Depth profile concentration analysis suggests a fundamental difference between the diffusion mechanisms of silver and nickel. Since silver penetration profiles in pure lead give diffusion coefficients independent of the penetration depth and silver concentration, it is suggested that slight decreases of silver diffusivity in lead-silver solid solutions have no significance. This implies that the interstitial silver atoms do not associate significantly with each other to form Ag-Ag dimers. In contrast, different behaviors of /sup 63/Ni depth profile concentration in pure lead and saturated PbNi solid solutions agree with a Ni-Ni interaction leading to the formation of less mobile dimers near the surface in pure lead

Prognostic value of predischarge 12 lead electrocardiogram after myocardial infarction compared with other routine clinical variables

NARCIS (Netherlands)

Fioretti, P.; Tijssen, J. G.; Azar, A. J.; Lazzeroni, E.; Brower, R. W.; ten Katen, H. J.; Lubsen, J.; Hugenholtz, P. G.

1987-01-01

The prognostic value of QRS score (Selvester), ST depression, ST elevation, extrasystoles, P terminal force in V1, and QTc derived from the predischarge 12 lead electrocardiogram was assessed after myocardial infarction in 474 patients without intraventricular conduction defects, ventricular

A stable lead isotopic investigation of the use of sycamore tree rings as a historical biomonitor of environmental lead contamination

Energy Technology Data Exchange (ETDEWEB)

Patrick, Gavin J. [School of GeoSciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JJ, Scotland (United Kingdom); Farmer, John G. [School of GeoSciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JJ, Scotland (United Kingdom)]. E-mail: J.G.Farmer@ed.ac.uk

2006-06-01

The validity of the use of sycamore (Acer pseudoplatanus) tree-rings for the reconstruction of atmospheric lead pollution histories was investigated. Tree cores spanning 1892-2003 were collected from several sycamores from the eastern shore of Loch Lomond, Scotland, an area with no local point sources of lead emission. The lead concentration and {sup 206}Pb/{sup 207}Pb profiles of the Loch Lomond region cores were compared with corresponding data for the {sup 21}Pb-dated loch sediment, and also with data for moss of known age from a Scottish herbarium collection. Two of the seven sycamore cores showed the same lead concentration trend as the lead flux to the loch, the rest having no similarity to either each other or the loch sediment record. Two further sycamore cores showed some similarity in their temporal {sup 206}Pb/{sup 207}Pb trends to those seen in the sediment and moss records, but only in part of their profiles, whilst the {sup 206}Pb/{sup 207}Pb ratios of the other sycamore cores remained relatively unchanged for the majority of the time covered, or exhibited an opposite trend. The {sup 206}Pb/{sup 207}Pb ratios of the tree cores were also mostly higher than those of the previously established records for any given time period. Tree cores covering 1878-2002 were also collected along transects from Wanlockhead and Tyndrum, two areas of former lead mining and smelting associated with distinct {sup 206}Pb/{sup 207}Pb ratios of 1.170 and 1.144, respectively. The Wanlockhead tree cores exhibited a generally decreasing trend in lead concentration with both time and distance from the lead mine. The characteristic {sup 206}Pb/{sup 207}Pb ratio of 1.170 was observed in samples close to the mine but a decrease in the influence of the mine-derived lead was observed in more distant samples. The tree sampled at Tyndrum showed elevated lead concentrations, which decreased with time, and a fairly constant {sup 206}Pb/{sup 207}Pb ratio of {approx} 1.15 reflecting input

Global Derivatives

DEFF Research Database (Denmark)

Andersen, Torben Juul

approaches to dealing in the global business environment." - Sharon Brown-Hruska, Commissioner, Commodity Futures Trading Commission, USA. "This comprehensive survey of modern risk management using derivative securities is a fine demonstration of the practical relevance of modern derivatives theory to risk......" provides comprehensive coverage of different types of derivatives, including exchange traded contracts and over-the-counter instruments as well as real options. There is an equal emphasis on the practical application of derivatives and their actual uses in business transactions and corporate risk...... management situations. Its key features include: derivatives are introduced in a global market perspective; describes major derivative pricing models for practical use, extending these principles to valuation of real options; practical applications of derivative instruments are richly illustrated...

Dominating Duffer’s Domain: Lessons for the U.S. Marine corps Information Operations Practitioner

Science.gov (United States)

2017-01-01

has learned 26 hard -won lessons that readers may find useful for the future conduct and planning of IO. The principles espoused here were derived from...to be frank, it wasn’t that hard . I had done the ten-day Intermediate MAGTF (Marine Air Ground Task Force) Information Operations Practitioner...paragraph, with no phases. It was, however, beauti- fully formatted , and the task listing had everything: military deception, electronic warfare, OPSEC

An Autoradiographic Study of the Process of Hormone Formation in the Thyroid Gland Under Various Experimental Conditions

Science.gov (United States)

1960-09-26

to be a generally recognized mechanism of antithyroid action of thiourea derivatives (Astwood, Frank- lin, Chaikoff, and Lerner, Ya. M. Kabak, I. E...expresses an original point of view concerning the mechanisms of the antithyroid action of thiourea: he considers, that an impoverishment of the thyroid...Vol. 30, No. 5, 31. Boyd, Dzh. A., Avtoradiografiya v biologii i meditsine (Auto- radiography in Biology and Medicine ), Moscow, 1957. Fittszheral’d

Electrical properties of a novel lead alkoxide precursor: Lead glycolate

International Nuclear Information System (INIS)

Tangboriboon, Nuchnapa; Pakdeewanishsukho, Kittikhun; Jamieson, Alexander; Sirivat, Anuvat; Wongkasemjit, Sujitra

2006-01-01

The reaction of lead acetate trihydrate Pb(CH 3 COO) 2 .3H 2 O and ethylene glycol, using triethylenetetramine (TETA) as a catalyst, provides in one step access to a polymer-like precursor of lead glycolate [-PbOCH 2 CH 2 O-]. On the basis of high-resolution mass spectroscopy, chemical analysis composition, FTIR, 13 C-solid state NMR and TGA, the lead glycolate precursor can be identified as a trimer structure. The FTIR spectrum demonstrates the characteristics of lead glycolate; the peaks at 1086 and 1042 cm -1 can be assigned to the C-O-Pb stretchings. The 13 C-solid state NMR spectrum gives notably only one peak at 68.639 ppm belonging to the ethylene glycol ligand. The phase transformations of lead glycolate and lead acetate trihydrate to lead oxide, their microstructures, and electrical properties were found to vary with increasing temperature. The lead glycolate precursor has superior electrical properties relative to those of lead acetate trihydrate, suggesting that the lead glycolate precursor can possibly be used as a starting material for producing electrical and semiconducting ceramics, viz. ferroelectric, anti-ferroelectric, and piezoelectric materials

Columnar metaplasia in a surgical mouse model of gastro-esophageal reflux disease is not derived from bone marrow-derived cell.

Science.gov (United States)

Aikou, Susumu; Aida, Junko; Takubo, Kaiyo; Yamagata, Yukinori; Seto, Yasuyuki; Kaminishi, Michio; Nomura, Sachiyo

2013-09-01

The incidence of esophageal adenocarcinoma has increased in the last 25 years. Columnar metaplasia in Barrett's mucosa is assumed to be a precancerous lesion for esophageal adenocarcinoma. However, the induction process of Barrett's mucosa is still unknown. To analyze the induction of esophageal columnar metaplasia, we established a mouse gastro-esophageal reflux disease (GERD) model with associated development of columnar metaplasia in the esophagus. C57BL/6 mice received side-to-side anastomosis of the esophagogastric junction with the jejunum, and mice were killed 10, 20, and 40 weeks after operation. To analyze the contribution of bone marrow-derived cells to columnar metaplasia in this surgical GERD model, some mice were transplanted with GFP-marked bone marrow after the operation. Seventy-three percent of the mice (16/22) showed thickened mucosa in esophagus and 41% of mice (9/22) developed columnar metaplasia 40 weeks after the operation with a mortality rate of 4%. Bone marrow-derived cells were not detected in columnar metaplastic epithelia. However, scattered epithelial cells in the thickened squamous epithelia in regions of esophagitis did show bone marrow derivation. The results demonstrate that reflux induced by esophago-jejunostomy in mice leads to the development of columnar metaplasia in the esophagus. However, bone marrow-derived cells do not contribute directly to columnar metaplasia in this mouse model. © 2013 Japanese Cancer Association.

Synthesis and evaluation of antimalarial activity of curcumin derivatives

International Nuclear Information System (INIS)

Gomes, Patricia Ramos; Miguel, Fabio Balbino; Almeida, Mauro Vieira de; Couri, Mara Rubia Costa; Oliveira, Michael Eder de; Ferreira, Vanessa Viana; Guimaraes, Daniel Silqueira Martins; Lima, Aline Brito de; Barbosa, Camila de Souza; Oliveira, Mariana Amorim de; Almeida, Mauro Vieira de; Viana, Gustavo Henrique Ribeiro; Varotti, Fernando de Pilla

2014-01-01

ne of the main challenges in the development of new antimalarial drugs is to achieve a viable lead candidate with good pharmacokinetic properties. Curcumin has a broad range of biological activities, including antimalarial activity. Herein, we report the antimalarial activity of six curcumin derivatives (6-12) and an initial analysis of their pharmacokinetic properties. Five compounds have demonstrated potent activity against the P. falciparum in vitro (IC 50 values ranging from 1.7 to 15.2 μg mL -1 ), with moderate or low cytotoxicity against the HeLa cell line. The substitution of the carbonyl group in 6 by a 2,4-dinitrophenylhydrazone group (to afford 11) increases the Selective Index. These preliminary results indicate curcumin derivatives as potential antimalarial compounds. (author)

Relational Leading

DEFF Research Database (Denmark)

Larsen, Mette Vinther; Rasmussen, Jørgen Gulddahl

2015-01-01

This first chapter presents the exploratory and curious approach to leading as relational processes – an approach that pervades the entire book. We explore leading from a perspective that emphasises the unpredictable challenges and triviality of everyday life, which we consider an interesting......, relevant and realistic way to examine leading. The chapter brings up a number of concepts and contexts as formulated by researchers within the field, and in this way seeks to construct a first understanding of relational leading....

Lead isotope results of acid leaching experiments on acid volcanics and black shales in an ore environment

International Nuclear Information System (INIS)

Gulson, B.L.

1977-01-01

In the volcanogenic Woodlawn Cu-Pb-Zn deposit, where pyrite is the dominant sulphide phase in the ore and a ubiquitous mineral in the host volcanics and shales, leaching experiments using HNO 3 -HCl to overcome the ore/rock lead dominance, resulted in highly complex lead isotopic data, dependent mainly on the original lead concentration in the rock. For samples with higher (> 5 ppm) lead concentrations, the acid leaches are less radiogenic than the rocks or residues whereas for samples with 15 ppm lead, the data arrays are those expected for a dominance of ore/rock lead. In all except the very high lead samples (> 100 ppm), lead is derived from sources other than sulphides. Furthermore, in only the highest lead sample is the acid leach isotopic value compatible with that of the ore lead. As found in previous leaching investigations, the dominant component of lead and uranium is extracted in the acid leach. Acid-leaching experiments of this type may have possible applications in prospecting for basemetal sulphides. (auth.)

Brain-derived neurotrophic factor and addiction: Pathological versus therapeutic effects on drug seeking

NARCIS (Netherlands)

Barker, J.M.; Taylor, J.R.; de Vries, T.J.; Peters, J.

2015-01-01

Many abused drugs lead to changes in endogenous brain-derived neurotrophic factor (BDNF) expression in neural circuits responsible for addictive behaviors. BDNF is a known molecular mediator of memory consolidation processes, evident at both behavioral and neurophysiological levels. Specific neural

Correlation between some parameters of lead absorption and lead intoxication

Science.gov (United States)

Waldron, H. A.

1971-01-01

Waldron, H. A. (1971).Brit. J. industr. Med.,28, 195-199. Correlation between some parameters of lead absorption and lead intoxication. Use has been made of data collected over a number of years from workers exposed to a lead hazard in a motor-car factory. The correlations between various parameters of lead absorption and lead intoxication were computed, including blood and urine lead concentrations, urinary coproporphyrin, ALA and PBG concentrations, and haemoglobin concentration. In all, 15 correlation coefficients were calculated, of which only six showed a statistically significant result (i.e., Plead and urine lead (r = 0·38, Plead and coproporphyrin (r = 0·42, Plead and ALA (r = 0·43, Plead and PBG (r = 0·19, P<0·05). PMID:5572689

Hydrostatic pressure dependence of elastic constants for lead fluoride crystal

International Nuclear Information System (INIS)

Singh, R.K.; Rao, C.N.

1988-10-01

The variations of the second order elastic constants (SOEC) and longitudinal and shear moduli with hydrostatic pressure for the lead fluoride have been investigated theoretically, for the first time, by means of a three-body force potential (TBP) model. The significance of three-body interactions (TBI) has been clearly demonstrated in these investigations. The present TBP model has reproduced the pressure derivatives of the SOEC of PbF more satisfactorily than the shell model and other model calculations. (author). 24 refs, 3 figs, 2 tabs

First detection of lead in black paper from intraoral film

Energy Technology Data Exchange (ETDEWEB)

Guedes, Debora F.C., E-mail: defcg@usp.br [Departamento de Odontologia Restauradora, Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Av. do Cafe, S/N, Monte Alegre, CEP 14040-904, Ribeirao Preto, SP (Brazil); Silva, Reginaldo S. [Departamento de Odontologia Restauradora, Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Av. do Cafe, S/N, Monte Alegre, CEP 14040-904, Ribeirao Preto, SP (Brazil); Veiga, Marcia A.M.S. da [Departamento de Quimica, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Av. do Cafe, S/N, Monte Alegre, CEP 14040-904, Ribeirao Preto, SP (Brazil); Pecora, Jesus D. [Departamento de Odontologia Restauradora, Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Av. do Cafe, S/N, Monte Alegre, CEP 14040-904, Ribeirao Preto, SP (Brazil)

2009-10-30

Lead (Pb) contamination in the black paper that recovers intraoral films (BKP) has been investigated. BKP samples were collected from the Radiology Clinics of the Dental School of Ribeirao Preto, University of Sao Paulo, Brazil. For sake of comparison, four different methods were used. The results revealed the presence of high lead levels, well above the maximum limit allowed by the legislation. Pb contamination levels achieved after the following treatments: paper digestion in nitric acid, microwave treatment, DIN38414-54 method and TCLP method were 997 {mu}g g{sup -1}, 189 {mu}g g{sup -1}, 20.8 {mu}g g{sup -1}, and 54.0 {mu}g g{sup -1}, respectively. Flame atomic absorption spectrometry (FAAS) and inductively coupled plasma mass spectrometry (ICP-MS) were employed for lead determination according to the protocols of the applied methods. Lead contamination in used BKP was confirmed by scanning electron microscopy coupled with energy dispersive X-ray microanalysis (SEM-EDS). All the SEM imaging was carried out in the secondary electron mode (SE) and backscattered-electron mode (QBSD) following punctual X-ray fluorescence spectra. Soil contamination derived from this product revealed the urgent need of addressing this problem. These elevated Pb levels, show that a preliminary treatment of BKP is mandatory before it is disposed into the common trash. The high lead content of this material makes its direct dumping into the environment unwise.

Selecting Candidates for Key Leadership Positions in Program Executive Offices Ground Combat Systems and Combat Service and Combat Service Support

Science.gov (United States)

2016-10-14

start or continue a profitable growth pattern and boost morale and motivation, a poor decision may bring the company to the brink of financial...HON Frank Kendall issued a memorandum titled “Key Leadership Positions and Qualification Criteria” (Kendall, 2013). This memorandum provides a...Chief Developmental Tester • Program Lead, Business Financial Manager SELECTING CANDIDATES FOR KEY LEADERSHIP POSITIONS 4

Reassessment of the role of stress in development of radiation-induced microstructure

International Nuclear Information System (INIS)

Garner, F.A.; Wolfer, W.G.; Brager, H.R.

1978-10-01

Data are now accumulating which clearly demonstrate that the stress state plays a strong role in the development of void and dislocation microstructure in metals during neutron irradiation. In these experiments the application of a tensile biaxial stress state at constant fluence and temperature has been found to lead to a progressively decreasing metal density with increasing stress. The effect of stress on the concurrent development of voids, Frank interstitial loops and dislocation networks has been studied with transmission electron microscopy. The results of these experiments clearly show that the densities of both Frank loops and voids are enhanced by a tensile stress field, with the relevant operating variable being the hydrostatic stress. More importantly it appears that any anisotropy in the stress field is reflected in a corresponding anisotropy that develops in the number of Frank loops that form on the various (111) planes. The loop density that develops on each plane exhibits a clear and direct dependence on the resolved normal stress component at each plane. Although the data from these experiments have been previously interpreted to support the existence of stress-assisted nucleation mechanisms for both loops and voids, further analysis has shown both of these explanations to be deficient in one or more respects, and both models have been replaced

Hydrogenation of Penta-Graphene Leads to Unexpected Large Improvement in Thermal Conductivity.

Science.gov (United States)

Wu, Xufei; Varshney, Vikas; Lee, Jonghoon; Zhang, Teng; Wohlwend, Jennifer L; Roy, Ajit K; Luo, Tengfei

2016-06-08

Penta-graphene (PG) has been identified as a novel two-dimensional (2D) material with an intrinsic bandgap, which makes it especially promising for electronics applications. In this work, we use first-principles lattice dynamics and iterative solution of the phonon Boltzmann transport equation (BTE) to determine the thermal conductivity of PG and its more stable derivative, hydrogenated penta-graphene (HPG). As a comparison, we also studied the effect of hydrogenation on graphene thermal conductivity. In contrast to hydrogenation of graphene, which leads to a dramatic decrease in thermal conductivity, HPG shows a notable increase in thermal conductivity, which is much higher than that of PG. Considering the necessity of using the same thickness when comparing thermal conductivity values of different 2D materials, hydrogenation leads to a 63% reduction in thermal conductivity for graphene, while it results in a 76% increase for PG. The high thermal conductivity of HPG makes it more thermally conductive than most other semiconducting 2D materials, such as the transition metal chalcogenides. Our detailed analyses show that the primary reason for the counterintuitive hydrogenation-induced thermal conductivity enhancement is the weaker bond anharmonicity in HPG than PG. This leads to weaker phonon scattering after hydrogenation, despite the increase in the phonon scattering phase space. The high thermal conductivity of HPG may inspire intensive research around HPG and other derivatives of PG as potential materials for future nanoelectronic devices. The fundamental physics understood from this study may open up a new strategy to engineer thermal transport properties of other 2D materials by controlling bond anharmonicity via functionalization.

Associated factors for higher lead and cadmium blood levels, and reference values derived from general population of São Paulo, Brazil

International Nuclear Information System (INIS)

Kira, Carmen Silvia; Sakuma, Alice Momoyo; De Capitani, Eduardo Mello; Umbelino de Freitas, Clarice; Cardoso, Maria Regina Alves; Gouveia, Nelson

2016-01-01

Human activities are associated with emissions of various metals into the environment, among which the heavy metals lead and cadmium stand out, as they pose a risk to human life even at low concentrations. Thus, accurate knowledge of the levels of these metals exhibited by the overall population, including children, is important. The aim of this study was to estimate the concentrations of lead and cadmium in the blood of adults, adolescents and children residing in the city of São Paulo, assess factors associated with higher lead and cadmium blood levels, and to establish reference values for this population. The study sample consisted of 669 adults over 20 years old, 264 adolescents aged 12 to 19 years old and 391 children under 11 years old from both genders. The samples were collected at the end of 2007 and during 2008 in different city zones. Higher blood lead concentration was significantly associated with gender, smoking, offal intake, area of residence and age. The blood cadmium concentration was significantly associated with gender, smoking, consumption of distilled beverages and age. The reference values of lead and cadmium established for adults above 20 years old were 33 μg/L and 0.6 μg/L, respectively, for adolescents (12 to 19 years old) were 31 μg/L and 0.6 μg/L, respectively and for children under 11 years old were 29 μg/L and 0.2 μg/L, respectively. The results of this study indicate that the exposure levels of the investigated population to lead and cadmium are low. - Highlights: • The exposure of population of São Paulo city to lead and cadmium is low. • Pb level was associated with gender, smoking, offal intake, area of residence, age. • Cd level was associated with gender, smoking, distilled beverages, age. • RV for Pb in blood for children and adolescents were 29 and 31 μg/L, respectively. • RV for Cd in blood for children and adolescents were 0.2 and 0.6 μg/L, respectively.

Associated factors for higher lead and cadmium blood levels, and reference values derived from general population of São Paulo, Brazil

Energy Technology Data Exchange (ETDEWEB)

Kira, Carmen Silvia, E-mail: carmkira@ial.sp.gov.br [Instituto Adolfo Lutz, Centro de Materiais de Referência, Av. Dr. Arnaldo, 355, São Paulo, SP CEP 01246-000 (Brazil); Sakuma, Alice Momoyo [Instituto Adolfo Lutz, Centro de Materiais de Referência, Av. Dr. Arnaldo, 355, São Paulo, SP CEP 01246-000 (Brazil); De Capitani, Eduardo Mello [Universidade Estadual de Campinas — UNICAMP, Faculdade de Ciências Médicas, Departamento de Clínica Médica, Centro de Controle de Intoxicações (Brazil); Umbelino de Freitas, Clarice [Secretaria de Estado da Saúde/SP, Coordenadoria de Controle de Doenças (Brazil); Cardoso, Maria Regina Alves [Universidade de São Paulo, Faculdade de Saúde Pública, Departamento de Epidemiologia (Brazil); Gouveia, Nelson [Universidade de São Paulo — USP, Faculdade de Medicina, Departamento de Medicina Preventiva (Brazil)

2016-02-01

Human activities are associated with emissions of various metals into the environment, among which the heavy metals lead and cadmium stand out, as they pose a risk to human life even at low concentrations. Thus, accurate knowledge of the levels of these metals exhibited by the overall population, including children, is important. The aim of this study was to estimate the concentrations of lead and cadmium in the blood of adults, adolescents and children residing in the city of São Paulo, assess factors associated with higher lead and cadmium blood levels, and to establish reference values for this population. The study sample consisted of 669 adults over 20 years old, 264 adolescents aged 12 to 19 years old and 391 children under 11 years old from both genders. The samples were collected at the end of 2007 and during 2008 in different city zones. Higher blood lead concentration was significantly associated with gender, smoking, offal intake, area of residence and age. The blood cadmium concentration was significantly associated with gender, smoking, consumption of distilled beverages and age. The reference values of lead and cadmium established for adults above 20 years old were 33 μg/L and 0.6 μg/L, respectively, for adolescents (12 to 19 years old) were 31 μg/L and 0.6 μg/L, respectively and for children under 11 years old were 29 μg/L and 0.2 μg/L, respectively. The results of this study indicate that the exposure levels of the investigated population to lead and cadmium are low. - Highlights: • The exposure of population of São Paulo city to lead and cadmium is low. • Pb level was associated with gender, smoking, offal intake, area of residence, age. • Cd level was associated with gender, smoking, distilled beverages, age. • RV for Pb in blood for children and adolescents were 29 and 31 μg/L, respectively. • RV for Cd in blood for children and adolescents were 0.2 and 0.6 μg/L, respectively.

Calibration equations for energy-dispersive XRF determination of copper, iron and lead in copper ore slurries

International Nuclear Information System (INIS)

Lakosz, M.

1976-01-01

Calibration equations for the X-ray fluorescence analysis determination of copper, iron and lead in copper ore slurries have been derived and tested. The measurement of Ksub(α) lines of copper and iron and Lsub(α) line of lead excited by rays from 238 Pu source have been used. Si/Li detector coupled to multichannel analyzer and minicomputer have been applied in measurements. The matrix and density effect have been eliminated by additional measurement of back-scattered primary radiation. (author)

Sharing Malaysian experience with the development of biotechnology-derived food crops.

Science.gov (United States)

Abu Bakar, Umi K; Pillai, Vilasini; Hashim, Marzukhi; Daud, Hassan Mat

2005-12-01

Biotechnology-derived food crops are currently being developed in Malaysia mainly for disease resistance and improved post harvest quality. The modern biotechnology approach is adopted because of its potential to overcome constraints faced by conventional breeding techniques. Research on the development of biotechnology-derived papaya, pineapple, chili, passion fruit, and citrus is currently under way. Biotechnology-derived papaya developed for resistance to papaya ringspot virus (PRSV) and improved postharvest qualities is at the field evaluation stage. Pineapple developed for resistance to fruit black heart disorder is also being evaluated for proof-of-concept. Other biotechnology-derived food crops are at early stages of gene cloning and transformation. Activities and products involving biotechnology-derived crops will be fully regulated in the near future under the Malaysian Biosafety Law. At present they are governed only by guidelines formulated by the Genetic Modification Advisory Committee (GMAC), Malaysia. Commercialization of biotechnology-derived crops involves steps that require GMAC approval for all field evaluations and food-safety assessments before the products are placed on the market. Public acceptance of the biotechnology product is another important factor for successful commercialization. Understanding of biotechnology is generally low among Malaysians, which may lead to low acceptance of biotechnology-derived products. Initiatives are being taken by local organizations to improve public awareness and acceptance of biotechnology. Future research on plant biotechnology will focus on the development of nutritionally enhanced biotechnology-derived food crops that can provide more benefits to consumers.

Synthesis and characterization of cellulose derivatives obtained from bacterial cellulose

International Nuclear Information System (INIS)

Oliveira, Rafael L. de; Barud, Hernane; Ribeiro, Sidney J.L.; Messaddeq, Younes

2011-01-01

The chemical modification of cellulose leads to production of derivatives with different properties from those observed for the original cellulose, for example, increased solubility in more traditional solvents. In this work we synthesized four derivatives of cellulose: microcrystalline cellulose, cellulose acetate, methylcellulose and carboxymethylcellulose using bacterial cellulose as a source. These were characterized in terms of chemical and structural changes by examining the degree of substitution (DS), infrared spectroscopy (FTIR) and nuclear magnetic resonance spectroscopy - NMR 13 C. The molecular weight and degree of polymerization were evaluated by viscometry. The characterization of the morphology of materials and thermal properties were performed with the techniques of X-ray diffraction, electron microscopy images, differential scanning calorimetry (DSC) and thermogravimetric analysis. (author)

SYNTHESIS OF SOME PROLINE DERIVATIVES BY MEANS OF MICHAEL ADDITIONS OF GLYCINE ESTERS

NARCIS (Netherlands)

VANDERWERF, A; KELLOGG, RM

1991-01-01

Addition of the Schiff bases derived from reaction of glycine alkyl esters with benzophenoneimine to alpha,beta-unsaturated ketones, followed by hydrogenation of the addition products, leads to 5- or 3,5-substituted prolines. Hydrolysis of the Michael adducts rather than hydrogenation allows

Identification and Characterization of 293T Cell-Derived Exosomes by Profiling the Protein, mRNA and MicroRNA Components.

Directory of Open Access Journals (Sweden)

Jing Li

Full Text Available Cell-derived exosomes are leading candidates for in vivo drug delivery carriers. In particular, exosomes derived from 293T cells are used most frequently, although exosome dosing has varied greatly among studies. Considering their biological origin, it is crucial to characterize the molecular composition of exosomes if large doses are to be administered in clinical settings. In this study, we present the first comprehensive analysis of the protein, messenger RNA and microRNA profiles of 293T cell-derived exosomes; then, we characterized these data using Gene Ontology annotation and Kyoto Encyclopedia for Genes and Genomes pathway analysis. Our study will provide the basis for the selection of 293T cell-derived exosome drug delivery systems. Profiling the exosomal signatures of 293T cells will lead to a better understanding of 293T exosome biology and will aid in the identification of any harmful factors in exosomes that could cause adverse clinical effects.

The identification of lead ammunition as a source of lead exposure in First Nations: The use of lead isotope ratios

International Nuclear Information System (INIS)

Tsuji, Leonard J.S.; Wainman, Bruce C.; Martin, Ian D.; Sutherland, Celine; Weber, Jean-Philippe; Dumas, Pierre; Nieboer, Evert

2008-01-01

The use of lead shotshell to hunt water birds has been associated with lead-contamination in game meat. However, evidence illustrating that lead shotshell is a source of lead exposure in subsistence hunting groups cannot be deemed definitive. This study seeks to determine whether lead shotshell constitutes a source of lead exposure using lead isotope ratios. We examined stable lead isotope ratios for lichens, lead shotshell and bullets, and blood from residents of Fort Albany and Kashechewan First Nations, and the City of Hamilton, Ontario, Canada. Data were analyzed using ANOVA and regression analyses. ANOVA of isotope ratios for blood revealed significant differences with respect to location, but not sex. Hamilton differed from both Kashechewan and Fort Albany; however, the First Nations did not differ from each other. ANOVA of the isotope ratios for lead ammunition and lichens revealed no significant differences between lichen groups (north and south) and for the lead ammunition sources (pellets and bullets). A plot of 206 Pb/ 204 Pb and 206 Pb/ 207 Pb values illustrated that lichens and lead ammunition were distinct groupings and only the 95% confidence ellipse of the First Nations group overlapped that of lead ammunition. In addition, partial correlations between blood-lead levels (adjusted for age) and isotope ratios revealed significant (p 206 Pb/ 204 Pb and 206 Pb/ 207 Pb, and a significant negative correlation for 208 Pb/ 206 Pb, as predicted if leaded ammunition were the source of lead exposure. In conclusion, lead ammunition was identified as a source of lead exposure for First Nations people; however, the isotope ratios for lead shotshell pellets and bullets were indistinguishable. Thus, lead-contaminated meat from game harvested with lead bullets may also be contributing to the lead body burden

Effect on blood lead of airborne lead particles characterized by size.

Science.gov (United States)

Park, Dong-Uk; Paik, Nam-Won

2002-03-01

Worker exposure to airborne lead particles was evaluated for a total of 117 workers in 12 work-places of four different industrial types in Korea. The particle sizes were measured using 8-stage cascade impactors worn by the workers. Mass median aerodynamic diameters (MMAD) were determined by type of industry and percentage of lead particles as a fraction of airborne lead (PbA) concentration was determined by particle size. Blood lead (PbB) levels of workers who matched airborne lead samples were also examined. A Scheffé's pairwise comparison test showed that MMAD and the fractions of each of respirable particles and lead particles lead particles lead particles (r = 0.82) than that between concentrations of small particles and PbA (r = 0.61). A simple linear regression indicated that PbB correlated better with respirable lead concentration (r2 = 0.35, P = 0.0001) than with PbA concentration and had a higher slope coefficient. Controlling for respirable lead concentration reduced the partial correlation coefficient between PbA concentration and PbB level from 0.56 to 0.20 (P = 0.053). The results indicate that the contribution of respirable lead particles to lead absorption would be greater than that of PbA. This study concludes that the measurement of PbA only may not properly reflect a worker's exposure to lead particles with diverse characteristics. For the evaluation of a worker's exposure to various types of lead particles, it is recommended that respirable lead particles as well as PbA be measured.

Approximate *-derivations and approximate quadratic *-derivations on C*-algebras

Directory of Open Access Journals (Sweden)

Park Choonkil

2011-01-01

Full Text Available Abstract In this paper, we prove the stability of *-derivations and of quadratic *-derivations on Banach *-algebras. We moreover prove the superstability of *-derivations and of quadratic *-derivations on C*-algebras. 2000 Mathematics Subject Classification: 39B52; 47B47; 46L05; 39B72.

Common ECG Lead Placement Errors. Part I: Limb Lead Reversals

Directory of Open Access Journals (Sweden)

Allison V. Rosen

2015-10-01

Full Text Available Background: Electrocardiography (ECG is a very useful diagnostic tool. However, errors in placement of ECG leads can create artifacts, mimic pathologies, and hinder proper ECG interpretation. It is important for members of the health care team to be able to recognize the common patterns resulting from lead placement errors. Methods: 12-lead ECGs were recorded in a single male healthy subject in his mid 20s. Six different limb lead reversals were compared to ECG recordings from correct lead placement. Results: Classic ECG patterns were observed when leads were reversed. Methods of discriminating these ECG patterns from true pathologic findings were described. Conclusion: Correct recording and interpretation of ECGs is key to providing optimal patient care. It is therefore crucial to be able to recognize common ECG patterns that are indicative of lead reversals.

75 FR 76706 - Acceptance of Public Submissions on a Study Mandated by the Dodd-Frank Wall Street Reform and...

Science.gov (United States)

2010-12-09

... (``ontologies'') to define and describe derivatives transactions and positions? If yes, what computer language... industry to adopt standardized computer-readable algorithmic descriptions which may be used to describe... derivatives industry to adopt standardized computer- readable algorithmic descriptions which may be [[Page...

LEADING WITH LEADING INDICATORS

International Nuclear Information System (INIS)

PREVETTE, S.S.

2005-01-01

This paper documents Fluor Hanford's use of Leading Indicators, management leadership, and statistical methodology in order to improve safe performance of work. By applying these methods, Fluor Hanford achieved a significant reduction in injury rates in 2003 and 2004, and the improvement continues today. The integration of data, leadership, and teamwork pays off with improved safety performance and credibility with the customer. The use of Statistical Process Control, Pareto Charts, and Systems Thinking and their effect on management decisions and employee involvement are discussed. Included are practical examples of choosing leading indicators. A statistically based color coded dashboard presentation system methodology is provided. These tools, management theories and methods, coupled with involved leadership and employee efforts, directly led to significant improvements in worker safety and health, and environmental protection and restoration at one of the nation's largest nuclear cleanup sites

Synthesis of febrifugine derivatives and development of an effective and safe tetrahydroquinazoline-type antimalarial.

Science.gov (United States)

Kikuchi, Haruhisa; Horoiwa, Seiko; Kasahara, Ryota; Hariguchi, Norimitsu; Matsumoto, Makoto; Oshima, Yoshiteru

2014-04-09

Febrifugine, a quinazoline alkaloid isolated from Dichroa febrifuga roots, shows powerful antimalarial activity against Plasmodium falciparum. Although the use of ferifugine as an antimalarial drug has been precluded because of its severe side effects, its potent antimalarial activity has stimulated medicinal chemists to pursue its derivatives instead, which may provide valuable leads for novel antimalarial drugs. In the present study, we synthesized new derivatives of febrifugine and evaluated their in vitro and in vivo antimalarial activities to develop antimalarials that are more effective and safer. As a result, we proposed tetrahydroquinazoline-type derivative as a safe and effective antimalarial candidate. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Functional derivative of noninteracting kinetic energy density functional

International Nuclear Information System (INIS)

Liu Shubin; Ayers, Paul W.

2004-01-01

Proofs from different theoretical frameworks, namely, the Hohenbergh-Kohn theorems, the Kohn-Sham scheme, and the first-order density matrix representation, have been presented in this paper to show that the functional derivative of the noninteracting kinetic energy density functional can uniquely be expressed as the negative of the Kohn-Sham effective potential, arbitrary only to an additive orbital-independent constant. Key points leading to the current result as well as confusion about the quantity in the literature are briefly discussed

Performance and exposure indices of rats exposed to low concentrations of lead.

Science.gov (United States)

Cory-Slechta, D A; Weiss, B; Cox, C

1985-04-01

To further characterize the lower end of the function relating lead exposure and biological exposure indices to behavior, male weanling rats were exposed chronically to drinking solutions containing 25 ppm sodium acetate (controls) or 25 ppm lead acetate. Behavioral training began when the animals reached 50 days of age, and performance on a fixed-interval 1-min schedule of food reinforcement was then assessed over 90 experimental sessions (136 days). This exposure produced overall response rate increases over the first 40 sessions that were similar to those observed previously with higher concentrations of lead. Response rates of the two groups tended to merge subsequently. The increased overall response rates in the treated group derived primarily from an increased frequency of shorter interresponse times (IRTs) and increased running rates (calculated without the postreinforcement interval). Blood lead (PbB) and zinc protoporphyrin (ZPP) values were determined following sessions 30, 60, and 90. PbB values of the lead-exposed group averaged 15 to 20 micrograms/dl throughout the study; ZPP did not differ. The mean brain lead value of the treated group was 0.07 micrograms Pb/g. Blood-brain ratios (1.38 to 4.06) were substantially greater than those previously observed at higher exposures. These data extend to even lower exposures, and lower blood lead concentrations, the effective concentration for behavioral effects, and further emphasize the importance of the sensitivity of the endpoint in assessing behavioral toxicity.

Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells.

Science.gov (United States)

Michel, Anastasija; Schüler, Andrea; Friedrich, Pamela; Döner, Fatma; Bopp, Tobias; Radsak, Markus; Hoffmann, Markus; Relle, Manfred; Distler, Ute; Kuharev, Jörg; Tenzer, Stefan; Feyerabend, Thorsten B; Rodewald, Hans-Reimer; Schild, Hansjörg; Schmitt, Edgar; Becker, Marc; Stassen, Michael

2013-06-01

Mast cell-deficient Kit(W-sh) "sash" mice are widely used to investigate mast cell functions. However, mutations of c-Kit also affect additional cells of hematopoietic and nonimmune origin. In this study, we demonstrate that Kit(W-sh) causes aberrant extramedullary myelopoiesis characterized by the expansion of immature lineage-negative cells, common myeloid progenitors, and granulocyte/macrophage progenitors in the spleen. A consistent feature shared by these cell types is the reduced expression of c-Kit. Populations expressing intermediate and high levels of Ly6G, a component of the myeloid differentiation Ag Gr-1, are also highly expanded in the spleen of sash mice. These cells are able to suppress T cell responses in vitro and phenotypically and functionally resemble myeloid-derived suppressor cells (MDSC). MDSC typically accumulate in tumor-bearing hosts and are able to dampen immune responses. Consequently, transfer of MDSC from naive sash mice into line 1 alveolar cell carcinoma tumor-bearing wild-type littermates leads to enhanced tumor progression. However, although it can also be observed in sash mice, accelerated growth of transplanted line 1 alveolar cell carcinoma tumors is a mast cell-independent phenomenon. Thus, the Kit(W-sh) mutation broadly affects key steps in myelopoiesis that may have an impact on mast cell research.

The Pericytic Phenotype of Adipose Tissue-Derived Stromal Cells Is Promoted by NOTCH2

NARCIS (Netherlands)

Terlizzi, Vincenzo; Kolibabka, Matthias; Burgess, Janette Kay; Hammes, Hans Peter; Harmsen, Martin Conrad

Long-term diabetes leads to macrovascular and microvascular complication. In diabetic retinopathy (DR), persistent hyperglycemia causes permanent loss of retinal pericytes and aberrant proliferation of microvascular endothelial cells (ECs). Adipose tissue-derived stromal cells (ASCs) may serve to

Secondary lead production

Energy Technology Data Exchange (ETDEWEB)

Hollis, R.G.

1990-10-16

This invention is concerned with the efficient recovery of soft lead from the paste component of used automobile lead-acid storage batteries. According to the invention, a scrap which contains lead oxide, lead sulfate, and antimony in an oxidized state is processed in the following steps to recover lead. A refractory lined reaction vessel is continuously charged with the scrap, along with a reductant effective for reducing lead oxide. The charged material is melted and agitated by means of a submerged lance at 900-1150{degree}C whereby some of the lead oxide of the scrap is reduced to form molten lead. A slag layer is then formed above the molten lead, and an amount of lead oxide is maintained in the slag layer. The molten lead, now containing under 0.5 wt % of antimony, is removed, and the antimony oxide in the scrap is concentrated as oxide in the slag layer. Preferred embodiments of the invention result in the production, in a single step, of a soft lead substantially free of antimony. The slag may be subsequently treated to reduce the antimony oxide and produce a valuable antimony-lead product. Further advantages of the process are that a wet battery paste may be used as the feed without prior drying, and the process can be conducted at a temperature 100-150{degree}C lower than in previously known methods. In addition, a smaller reactor can be employed which reduces both capital cost and fuel costs. The process of the invention is illustrated by descriptions of pilot plant tests. 1 fig.

2-Arylbenzo[b]furan derivatives as potent human lipoxygenase inhibitors.

Science.gov (United States)

Lang, Li; Dong, Ningning; Wu, Deyan; Yao, Xue; Lu, Weiqiang; Zhang, Chen; Ouyang, Ping; Zhu, Jin; Tang, Yun; Wang, Wei; Li, Jian; Huang, Jin

2016-01-01

Human lipoxygenases (LOXs) have been emerging as effective therapeutic targets for inflammatory diseases. In this study, we found that four natural 2-arylbenzo[b]furan derivatives isolated from Artocarpus heterophyllus exhibited potent inhibitory activities against human LOXs, including moracin C (1), artoindonesianin B-1 (2), moracin D (3), moracin M (4). In our in vitro experiments, compound 1 was identified as the most potent LOX inhibitor and the moderate subtype selective inhibitor of 12-LOX. Compounds 1 and 2 act as competitive inhibitors of LOXs. Moreover, 1 significantly inhibits LTB4 production and chemotactic capacity of neutrophils, and is capable of protecting vascular barrier from plasma leakage in vivo. In addition, the preliminary structure-activity relationship analysis was performed based on the above four naturally occurring (1-4) and six additional synthetic 2-arylbenzo[b]furan derivatives. Taken together, these 2-arylbenzo[b]furan derivatives, as LOXs inhibitors, could represent valuable leads for the future development of therapeutic agents for inflammatory diseases.

Kinetics of oil saponification by lead salts in ancient preparations of pharmaceutical lead plasters and painting lead mediums.

Science.gov (United States)

Cotte, M; Checroun, E; Susini, J; Dumas, P; Tchoreloff, P; Besnard, M; Walter, Ph

2006-12-15

Lead soaps can be found in archaeological cosmetics as well as in oil paintings, as product of interactions of lead salts with oil. In this context, a better understanding of the formation of lead soaps allows a follow-up of the historical evolution of preparation recipes and provides new insights into conservation conditions. First, ancient recipes of both pharmaceutical lead plasters and painting lead mediums, mixtures of oil and lead salts, were reconstructed. The ester saponification by lead salts is determined by the preparation parameters which were quantified by FT-IR spectrometry. In particular, ATR/FT-IR spectrometer was calibrated by the standard addition method to quantitatively follow the kinetics of this reaction. The influence of different parameters such as temperature, presence of water and choice of lead salts was assessed: the saponification is clearly accelerated by water and heating. This analysis provides chemical explanations to the historical evolution of cosmetic and painting preparation recipes.

Lead levels - blood

Science.gov (United States)

Blood lead levels ... is used to screen people at risk for lead poisoning. This may include industrial workers and children ... also used to measure how well treatment for lead poisoning is working. Lead is common in the ...

78 FR 26032 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

Science.gov (United States)

2013-05-03

..., North Carolina; Frank B. Holding, Sr., Smithfield, North Carolina; Ella Ann Holding, Smithfield, North..., individually and together with Olivia Britton Holding, Raleigh, North Carolina; Frank B. Holding, Sr... Brown Holding, Jr., Raleigh, North Carolina; Frank B. Holding, Sr., Smithfield, North Carolina; Ella Ann...

Resummed B→Xulν decay distributions to next-to-leading order

International Nuclear Information System (INIS)

Aglietti, U.

2001-01-01

We perform factorization of the most general distribution in semileptonic B→X u decays and we resum the threshold logarithms to next-to-leading order. From this (triple-differential) distribution, any other distribution is obtained by integration. As an application of our method, we derive simple analytical expressions for a few distributions, resummed to leading approximation. It is shown that the shape function can be directly determined by measuring the distribution in m X 2 /E X 2 , not in m X 2 /m B 2 . We compute the resummed hadron energy spectrum, which has a 'Sudakov shoulder', and we show how the distribution in the singular region is related to the shape function. We also present an improved formula for the photon spectrum in B→X s γ, which includes soft-gluon resummation and non-leading operators in the effective Hamiltonian. We explicitly show that the same non-perturbative function -- namely, the shape function -- controls the non-perturbative effects in all the distributions in the semileptonic and in the rare decay

The effect of variations in first- and second-order derivatives on airfoil aerodynamic performance

Directory of Open Access Journals (Sweden)

Penghui Yi

2017-01-01

Full Text Available The geometric factors which influence airfoil aerodynamic performance are attributed to variations in local first- and second-order curvature derivatives. Based on a self-developed computational fluid dynamics (CFD program called UCFD, the influence of local profile variations on airfoil aerodynamic performance in different pressure areas is investigated. The results show that variations in first- and second-order derivatives of the airfoil profiles can cause fluctuations in airfoil aerodynamic performance. The greater the variation in local first- and second-order derivatives, the greater the fluctuation amplitude of the airfoil aerodynamic coefficients. Moreover, at the area near the leading edge and the shock-wave position, the surface pressure is more sensitive to changes in first- and second-order derivatives. These results provide a reference for airfoil aerodynamic shape design.

Lead and osteoporosis: Mobilization of lead from bone in postmenopausal women

Energy Technology Data Exchange (ETDEWEB)

Silbergeld, E.K. (Environmental Defense Fund, WA (USA)); Schwartz, J. (Environmental Protection Agency, Washington, DC (USA)); Mahaffey, K. (National Institute of Environmental Health Sciences, Research Triangle Park, NC (USA))

1988-10-01

Although it has been known that humans accumulate lead in bone, mineralized tissue has been considered primarily as a sequestering compartment and not as a site of toxic action for lead. However, experimental data indicate that bone lead can be released during conditions of demineralization, such as pregnancy and lactation. We have examined lead status in women, before and after menopause, using the NHANES II dataset compiled between 1976 and 1980. In 2981 black and white women there was a highly significant increase in both whole blood and calculated plasma lead concentrations after menopause. The results indicate that bone lead is not an inert storage site for absorbed lead. Moreover, lead may interact with other factors in the course of postmenopausal osteoporosis, to aggravate the course of the disease, since lead is known to inhibit activation of vitamin D, uptake of dietary calcium, and several regulatory aspects of bone cell function. The consequences of this mobilization may also be of importance in assessing the risks of maternal lead exposure to fetal and infant health.

Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists

DEFF Research Database (Denmark)

Sasmal, Pradip K; Krishna, C Vamsee; Sudheerkumar Adabala, S

2015-01-01

Kappa opioid receptor (KOR) is an important mediator of pain signaling and it is targeted for the treatment of various pains. Pharmacophore based mining of databases led to the identification of 2-aminobenzimidazole derivative as KOR agonists with selectivity over the other opioid receptors DOR a...... of novel benzimidazole derivatives as KOR agonists are described. The in vivo proof of principle for anti-nociceptive effect with a lead compound from this series is exemplified....

The fractal dimension of architecture

CERN Document Server

Ostwald, Michael J

2016-01-01

Fractal analysis is a method for measuring, analysing and comparing the formal or geometric properties of complex objects. In this book it is used to investigate eighty-five buildings that have been designed by some of the twentieth-century’s most respected and celebrated architects. Including designs by Le Corbusier, Eileen Gray, Frank Lloyd Wright, Robert Venturi, Frank Gehry, Peter Eisenman, Richard Meier and Kazuyo Sejima amongst others, this book uses mathematics to analyse arguments and theories about some of the world’s most famous designs. Starting with 625 reconstructed architectural plans and elevations, and including more than 200 specially prepared views of famous buildings, this book presents the results of the largest mathematical study ever undertaken into architectural design and the largest single application of fractal analysis presented in any field. The data derived from this study is used to test three overarching hypotheses about social, stylistic and personal trends in design, along...

In vivo x-ray fluorescence of lead and other toxic trace elements

International Nuclear Information System (INIS)

Chettle, D.R.

1995-01-01

The first in vivo x-ray fluorescence measurements of lead in bone used y-rays from a 57 Co source to excite Pb K x-rays. Later systems used γ-rays from 109 Cd to excite Pb K x-rays or polarized x-rays to excite Ph L x-rays. All three approaches involve an extremely low effective dose to the subject. Of the two K x-ray techniques, 109 Cd is more precise and more flexible in choice of measurement site. Pb L x-ray fluorescence (L-XRF) effectively samples lead at bone surfaces, whereas Ph K x-ray fluorescence (K-XRF) samples through the bulk of a bone. Both the polarized L-XRF and 109 Cd K-XRF achieve similar precision. Renal mercury has recently been determined using a polarized x-ray source, Both renal and hepatic cadmium can be measured using polarized x-rays in conjunction with a Si(Li) detector. Platinum and gold have been measured both by radioisotopic source excitation and by using polarized x-rays, but the latter is to be preferred. Applications of Pb K-XRF have shown that measured bone lead relates strongly to cumulative lead exposure. Secondly, biological half lives of lead in different bone types have been estimated from limited longitudinal data sets and from some cross sectional surveys. Thirdly, the effect of bone lead as an endogenous source of lead has been demonstrated and it has been shown that a majority of circulating blood lead can be mobilized from bone, rather than deriving from new exposure, in some retired lead workers. 35 refs., 5 tabs

Safe leads and lead changes in competitive team sports

Science.gov (United States)

Clauset, A.; Kogan, M.; Redner, S.

2015-06-01

We investigate the time evolution of lead changes within individual games of competitive team sports. Exploiting ideas from the theory of random walks, the number of lead changes within a single game follows a Gaussian distribution. We show that the probability that the last lead change and the time of the largest lead size are governed by the same arcsine law, a bimodal distribution that diverges at the start and at the end of the game. We also determine the probability that a given lead is "safe" as a function of its size L and game time t . Our predictions generally agree with comprehensive data on more than 1.25 million scoring events in roughly 40 000 games across four professional or semiprofessional team sports, and are more accurate than popular heuristics currently used in sports analytics.

Strategy for management of investigation-derived waste

International Nuclear Information System (INIS)

Russell, Laura E.; Hopkins, Gregory G.; Smith, Edward H.; Innis, Pamela S.; Stewart, Robert K.

1992-01-01

Large quantities of wastes containing hazardous and/or radiological constituents are being generated as part of the field investigations at the U.S. Department of Energy's Hanford Site in Richland, Washington. A problem exists with the integration of regulations under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980, the Resource Conservation and Recovery Act of 1976, the Washington Hazardous Waste Management Act of 1976, and the Washington Administrative Code Waste management criteria under these regulations need to be consolidated into a single, acceptable management approach that can reasonably be applied to the Hanford Site cleanup effort. In response to this need, a Technical Task Team of representatives from the Washington Department of Ecology, U.S. Environmental Protection Agency, U.S. Department of Energy, and Westinghouse Hanford Company was organized. As a result of nearly two years of negotiations the Technical Task Team produced a specific waste management plan which is presented in the paper as the Strategy for Management of Investigation-Derived Waste. The paper outlines the strategy for handling and storing investigation-derived waste within a given operable unit until a waste unit-specific Record of Decision can be issued. To date, the Strategy for Management of Investigation-Derived Waste has not been finalized. However, formal approval by the U.S. Environmental Protection Agency is expected soon and will result in implementation of the management strategy at waste sites in which they have been identified as the lead regulatory agency. Negotiations with the Washington State Department of Ecology are ongoing. At the time of this writing, it is uncertain what the Washington State Department of Ecology's position will be regarding investigation-derived waste. Both the U.S. Environmental Protection Agency and the U.S. Department of Energy believe the Strategy for Management of Investigation-Derived Waste to be

Expedient synthesis of fused azepine derivatives using a sequential rhodium(II)-catalyzed cyclopropanation/1-aza-Cope rearrangement of dienyltriazoles.

Science.gov (United States)

Schultz, Erica E; Lindsay, Vincent N G; Sarpong, Richmond

2014-09-08

A general method for the formation of fused dihydroazepine derivatives from 1-sulfonyl-1,2,3-triazoles bearing a tethered diene is reported. The process involves an intramolecular cyclopropanation of an α-imino rhodium(II) carbenoid, leading to a transient 1-imino-2-vinylcyclopropane intermediate which rapidly undergoes a 1-aza-Cope rearrangement to generate fused dihydroazepine derivatives in moderate to excellent yields. The reaction proceeds with similar efficiency on gram scale. The use of catalyst-free conditions leads to the formation of a novel [4.4.0] bicyclic heterocycle. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Pathways for the release of polonium from a lead-bismuth spallation target (thermochemical calculation); Verfluechtigungspfade des Poloniums aus einem Pb-Bi-Spallationstarget (Thermochemische Kalkulation)

Energy Technology Data Exchange (ETDEWEB)

Eichler, B.; Neuhausen, J

2004-06-01

An analysis of literature data for the thermochemical constants of polonium reveals considerable discrepancies in the relations of these data among each other as well as in their expected trends within the chalcogen group. This fact hinders a reliable assessment of possible reaction paths for the release of polonium from a liquid lead-bismuth spallation target. In this work an attempt is made to construct a coherent data set for the thermochemical properties of polonium and some of its compounds that are of particular importance with respect to the behaviour of polonium in a liquid Pb-Bi target. This data set is based on extrapolations using general trends throughout the periodic table and, in particular, within the chalcogen group. Consequently, no high accuracy should be attributed to the derived data set. However, the data set derived in this work is consistent with definitely known experimental data. Furthermore, it complies with the general trends of physicochemical properties within the chalcogen group. Finally, well known relations between thermochemical quantities are fulfilled by the data derived in this work. Thus, given the lack of accurate experimental data it can be regarded as best available data. Thermochemical constants of polonium hydride, lead polonide and polonium dioxide are derived based on extrapolative procedures. Furthermore, the possibility of formation of the gaseous intermetallic molecule BiPo, which has been omitted from discussion up to now, is investigated. From the derived thermochemical data the equilibrium constants of formation, release and dissociation reactions are calculated for different polonium containing species. Furthermore equilibrium constants are determined for the reaction of lead polonide and polonium dioxide with hydrogen, water vapour and the target components lead and bismuth. The most probable release pathways are discussed. From thermochemical evaluations polonium is expected to be released from liquid lead

Placenta-derived exosomes: potential biomarkers of preeclampsia

Directory of Open Access Journals (Sweden)

Pillay P

2017-10-01

Full Text Available Preenan Pillay,1,2 Kogi Moodley,1 Jagidesa Moodley,3 Irene Mackraj3 1Discipline of Human Physiology, Nelson R Mandela School of Medicine, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa; 2Pearson Institute of Higher Education, Midrand, South Africa; 3Women’s Health and HIV Research Group, Nelson R Mandela School of Medicine, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa Abstract: Preeclampsia remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the lack of clarity on the etiology of the disorder. Although several clinical and biological markers of preeclampsia have been evaluated, they have proven to be ineffective in providing a definitive diagnosis during the various stages of the disorder. Exosomes have emerged as ideal biomarkers of pathological states, such as cancer, and have more recently gained interest in pregnancy-related complications, due to their role in cellular communication in normal and complicated pregnancies. This occurs as a result of the specific placenta-derived exosomal molecular cargo, which may be involved in normal pregnancy-associated immunological events, such as the maintenance of maternal–fetal tolerance. This review provides perspectives on placenta-derived exosomes as possible biomarkers for the diagnosis/prognosis of preeclampsia. Using keywords, online databases were searched to identify relevant publications to review the potential use of placenta-derived exosomes as biomarkers of preeclampsia. Keywords: placenta-derived exosomes, preeclampsia, biomarkers

[Environmental lead poisoning from lead-glazed earthenware used for storing drinks].

Science.gov (United States)

Sabouraud, S; Coppéré, B; Rousseau, C; Testud, F; Pulce, C; Tholly, F; Blanc, M; Culoma, F; Facchin, A; Ninet, J; Chambon, P; Medina, B; Descotes, J

2009-12-01

Current unusual environmental sources of lead exposure mainly include traditional medicines, either ayurvedic remedies or others, traditional cosmetics (kohl, surma), and the use of traditional earthenware, for storage or cooking. We report two cases of lead poisoning in adults initially identified by paroxysmal abdominal pain or anemia. In both cases, the environmental investigation evidenced one main source of lead exposure, namely a lead-glazed earthenware jug in which a drink was stored, "kefir" in the first case, and "kombucha" tea in the second one. It is recommended to search for lead intoxication in patients with unexplained anemia. Environmental sources of lead can be multiple. Their relative importance has to be ranked during the environmental investigation and among these, lead-glazed earthenware must be considered as a source of high lead exposure when drinks are stored inside and thus can soak.

A fence barrier method of leading edge cell capture for explorative biochemical research.

Science.gov (United States)

Wager, Lucas J; Murray, Rachael Z; Thompson, Erik W; Leavesley, David I

2017-09-03

The scratch or wound-healing assay is used ubiquitously for investigating re-epithelialisation and has already revealed the importance of cells comprising the leading edge of healing epithelial wounds. However it is currently limited to studying the effect of known biochemical agents on the tissue of choice. Here we present an adaptation that extends the utility of this model to encompass the collection of cells from the leading edge of migrating epithelial sheets making available explorative biochemical analyses. The method is scalable and does not require expensive apparatus, making it suitable for large and small laboratories alike. We detail the application of our method and exemplify proof of principle data derived from primary human keratinocyte cultures.

Lead pollution: lead content in milk from cows fed on contaminated forages

Energy Technology Data Exchange (ETDEWEB)

Sapetti, C; Arduino, E; Durio, P

1973-01-01

Lead toxicity is reviewed, and the history of the lead poisoning is described. Much of the lead pollution in soil is due to automobile exhaust. Two milk cows were fed forage with added lead acetate. The 20 kg of lead corresponded to 50 ppm, a level that is often found in hays near major highways. The cows milk was then analyzed for lead content. During the first and second phase of administration of lead salts, the milk cows did not show any evident symptoms of intoxication. The lead in the milk did have a marked correlation with the administered lead. The lead doses did not last long enough for chronic symptoms to begin. The dosage of lead in milk, due to the facility of drawing samples and the relevant levels of response, could represent a valid method for diagnosing incipient chronic intoxications.

Higher derivative couplings and massive supergravity in three dimensions

Energy Technology Data Exchange (ETDEWEB)

Kuzenko, Sergei M.; Novak, Joseph [School of Physics M013, The University of Western Australia,35 Stirling Highway, Crawley W.A. 6009 (Australia); Tartaglino-Mazzucchelli, Gabriele [School of Physics M013, The University of Western Australia,35 Stirling Highway, Crawley W.A. 6009 (Australia); Instituut voor Theoretische Fysica, KU Leuven,Celestijnenlaan 200D, B-3001 Leuven (Belgium)

2015-09-14

We develop geometric superspace settings to construct arbitrary higher derivative couplings (including R{sup n} terms) in three-dimensional supergravity theories with N≤3 by realising them as conformal supergravity coupled to certain compensators. For all known off-shell supergravity formulations, we construct supersymmetric invariants with up to and including four derivatives. As a warming-up exercise, we first give a new and completely geometric derivation of such invariants in N=1 supergravity. Upon reduction to components, they agree with those given in http://arxiv.org/abs/0907.4658 and http://arxiv.org/abs/1005.3952. We then carry out a similar construction in the case of N=2 supergravity for which there exist two minimal formulations that differ by the choice of compensating multiplet: (i) a chiral scalar multipet; (ii) a vector multiplet. For these formulations all four derivative invariants are constructed in completely general and gauge independent form. For a general supergravity model (in the N=1 and minimal N=2 cases) with curvature-squared and lower order terms, we derive the superfield equations of motion, linearise them about maximally supersymmetric backgrounds and obtain restrictions on the parameters that lead to models for massive supergravity. We use the non-minimal formulation for N=2 supergravity (which corresponds to a complex linear compensator) to construct a novel consistent theory of massive supergravity. In the case of N=3 supergravity, we employ the off-shell formulation with a vector multiplet as compensator to construct for the first time various higher derivative invariants. These invariants may be used to derive models for N=3 massive supergravity. As a bi-product of our analysis, we also present superfield equations for massive higher spin multiplets in (1,0), (1,1) and (2,0) anti-de Sitter superspaces.

Effect measure modification of blood lead-air lead slope factors.

Science.gov (United States)

Richmond-Bryant, Jennifer; Meng, Qingyu; Cohen, Jonathan; Davis, J Allen; Svendsgaard, David; Brown, James S; Tuttle, Lauren; Hubbard, Heidi; Rice, Joann; Kirrane, Ellen; Vinikoor-Imler, Lisa; Kotchmar, Dennis; Hines, Erin; Ross, Mary

2015-01-01

There is abundant literature finding that susceptibility factors, including race and ethnicity, age, and housing, directly influence blood lead levels. No study has explored how susceptibility factors influence the blood lead-air lead relationship nationally. The objective is to evaluate whether susceptibility factors act as effect measure modifiers on the blood lead-air lead relationship. Participant level blood lead data from the 1999 to 2008 National Health and Nutrition Examination Survey were merged with air lead data from the US Environmental Protection Agency. Linear mixed effects models were run with and without an air lead interaction term for age group, sex, housing age, or race/ethnicity to determine whether these factors are effect measure modifiers for all ages combined and for five age brackets. Age group and race/ethnicity were determined to be effect measure modifiers in the all-age model and for some age groups. Being a child (1-5, 6-11, and 12-19 years) or of Mexican-American ethnicity increased the effect estimate. Living in older housing (built before 1950) decreased the effect estimate for all models except for the 1-5-year group, where older housing was an effect measure modifier. These results are consistent with the peer-reviewed literature of time-activity patterns, ventilation, and toxicokinetics.

Lead - nutritional considerations

Science.gov (United States)

... billion people had toxic (poisonous) blood lead levels. Food Sources Lead can be found in canned goods if there is lead solder in the ... to bottled water for drinking and cooking. Avoid canned goods from foreign ... cans goes into effect. If imported wine containers have a lead foil ...

ASSET RECOVERY OF HAZARDOUS MATERIALS BENEFICIAL REUSE OF RADIOLOGICALLY ENCUMBERED LEAD STOCKS

International Nuclear Information System (INIS)

Lloyd, E.R.; Meehan, R.W.

2003-01-01

Underutilized and surplus lead stocks and leaded components are a common legacy environmental problem across much of the Department of Energy (DOE) Complex. While seeking to dispose of these items through its Environmental Management Program, DOE operational programs continue to pursue contemporary mission requirements such as managing and/or storing radioactive isotopes that require lead materials for shielding. This paradox was identified in late 1999 when DOE's policies for managing scrap metal were assessed. In January 2000, the Secretary of Energy directed the National Center of Excellence for Materials Recycle (NMR) to develop and implement a comprehensive lead reuse program for all of DOE. Fluor Hanford, contractor for DOE Richland Operations, subsequently contacted NMR to pilot lead reclamation and reuse at the Hanford Site. This relationship resulted in the development of a beneficial reuse pathway for lead reclaimed from spent fuel transport railcars being stored at Hanford. The 1.3 million pounds of lead in the railcars is considered radiologically encumbered due to its prior use. Further, the material was considered a mixed Resource Conservation and Recovery Act (RCRA) low-level radioactive waste that would require expensive storage or macro encapsulation to meet land disposal restrictions prior to burial. Working closely with Flour Hanford and the Office of Air, Water, and Radiation (EH-412), NMR developed a directed reuse pathway for this and other radiologically encumbered lead. When derived supplemental release limits were used, the lead recovered from these railcars became eligible for reuse in shielding products to support DOE and commercial nuclear industry operations. Using this disposition pathway has saved Hanford one third of the cost of disposing of the lead and the cost of acquiring additional lead for nuclear shielding applications. Furthermore, the environmental costs associated with mining and producing new lead for shielding products a

Nuclear accumulation of SHIP1 mutants derived from AML patients leads to increased proliferation of leukemic cells.

Science.gov (United States)

Nalaskowski, Marcus M; Ehm, Patrick; Rehbach, Christoph; Nelson, Nina; Täger, Maike; Modest, Kathrin; Jücker, Manfred

2018-05-28

The inositol 5-phosphatase SHIP1 acts as negative regulator of intracellular signaling in myeloid cells and is a tumor suppressor in myeloid leukemogenesis. After relocalization from the cytoplasm to the plasma membrane SHIP1 terminates PI3-kinase mediated signaling processes. Furthermore, SHIP1 is also found in distinct puncta in the cell nucleus and nuclear SHIP1 has a pro-proliferative function. Here we report the identification of five nuclear export signals (NESs) which regulate together with the two known nuclear localization signals (NLSs) the nucleocytoplasmic shuttling of SHIP1. Mutation of NLSs reduced the nuclear import and mutation of NESs decreased the nuclear export of SHIP1 in the acute myeloid leukemia (AML) cell line UKE-1. Interestingly, four SHIP1 mutants (K210R, N508D, V684E, Q1153L) derived from AML patients showed a nuclear accumulation after expression in UKE-1 cells. In addition, overexpression of the AML patient-derived mutation N508D caused an increased proliferation rate of UKE-1 cells in comparison to wild type SHIP1. Furthermore, we identified serine and tyrosine phosphorylation as a molecular mechanism for the regulation of nucleocytoplasmic shuttling of SHIP1 where tyrosine phosphorylation of distinct residues i.e. Y864, Y914, Y1021 reduces nuclear localization, whereas serine phosphorylation at S933 enhances nuclear localization of SHIP1. In summary, our data further implicate nuclear SHIP1 in cellular signaling and suggest that enhanced accumulation of SHIP1 mutants in the nucleus may be a contributory factor of abnormally high proliferation of AML cells. Copyright © 2017. Published by Elsevier Inc.

The refining of secondary lead for use in advanced lead-acid batteries

International Nuclear Information System (INIS)

Ellis, Timothy W.; Mirza, Abbas H.

2010-01-01

Secondary lead, i.e. material produced by the recycling of lead-acid batteries has become the primary source of lead in much of the world. This has been important to the secondary lead industry as other uses have dwindled, e.g. lead based pigments, chemicals, fuel additives, solders and CRT glasses. Presently, battery manufacturing accounts for greater than 80% of lead consumption while recycled lead accounts for approximately the same market share of lead supply. These two facts strongly demonstrate the battery manufacturing and recycled lead are intimately coupled in everyday life. In this paper we will explore how recycled lead has become the material of choice for battery construction through the development of a recovery and refining process that exceeds the industries requirements. Particular focus will be on addressing the results presented by Prengaman on the effects of contaminant or tramp elements on gassing in lead-acid batteries. (author)

Potential Biosignificant Interest and Surface Activity of Efficient Heterocyclic Derivatives.

Science.gov (United States)

El-Sayed, Refat; Althagafi, Ismail

2016-01-01

Some functionalized pyridine and fused system derivatives were synthesized using enaminonitrile derivative 5 as a starting material for the reaction, with various reagents under different conditions. Propoxylation of these compounds using different moles of propylene oxide (3, 5 and 7 moles) leads to a novel group of surface active agents. The antimicrobial and surface activities of the synthesized compounds were investigated. Most of the evaluated compounds proved to be active as antibacterial and antifungal agents and showed good surface activity, which makes them suitable for diverse applications such as the manufacturing of emulsifiers, cosmetics, drugs, pesticides, etc. Additionally, biodegradation testing exhibits significant breakdown within six to seven days, and hence, lowers the toxicity to human beings and becomes environmentally friendly.

The effect of lead-based paint hazard remediation on blood lead levels of lead poisoned children in New York City.

Science.gov (United States)

Leighton, Jessica; Klitzman, Susan; Sedlar, Slavenka; Matte, Thomas; Cohen, Neal L

2003-07-01

Despite the widespread use of lead paint hazard control for children with lead poisoning, few controlled studies that estimate the effect of such control on children's blood lead levels have been published. This retrospective follow-up study examined the effects of lead hazard remediation and its timing on the blood lead levels of lead-poisoned children. From the New York City child blood lead registry, 221 children were selected who had an initial blood lead level of 20-44 micro g/dL between 1 July 1994 and 31 December 1996; were 6 months to 6 years of age; had a report of a follow-up blood lead test between 10 and 14 months after the initial test; had a lead-based paint hazard identified in the primary dwelling unit prior to the 10- to 14-month follow-up blood lead test; had resided or spent time at only one address with an identified lead-based paint hazard; and were not chelated. The decline in geometric mean blood lead levels from baseline to 10-14 months later was compared for children whose homes were remediated and whose homes were not remediated during the follow-up period. Regardless of remediation, geometric mean blood lead levels declined significantly from 24.3 micro g/dL at the initial diagnosis to 12.3 micro g/dL at the 10- to 14-month follow-up blood lead test (Premediated the geometric mean blood lead levels declined 53% compared to 41% among the 75 children whose homes were not remediated by the follow-up blood lead test, a remediation effect of approximately 20% (Premediation effect was 11%, although it was no longer significant. Race was the only factor that appeared to confound the relationship: Black children had higher follow-up blood lead levels even after controlling for other factors, including the natural logarithm of the initial blood lead level. The effect of remediation appeared to be stronger for younger (10 to remediation (within less than 3 months) appeared to have greater declines in blood lead levels at the follow-up test than

Characteristics of lead isotope ratios and elemental concentrations in PM 10 fraction of airborne particulate matter in Shanghai after the phase-out of leaded gasoline

Science.gov (United States)

Zheng, Jian; Tan, Mingguang; Shibata, Yasuyuki; Tanaka, Atsushi; Li, Yan; Zhang, Guilin; Zhang, Yuanmao; Shan, Zuci

The stable lead (Pb) isotope ratios and the concentrations of 23 elements, including heavy metals and toxic elements, were measured in the PM 10 airborne particle samples collected at seven monitoring sites in Shanghai, China, to evaluate the current elemental compositions and local airborne Pb isotope ratio characteristics. Some source-related samples, such as cement, coal and oil combustion dust, metallurgic dust, vehicle exhaust particles derived from leaded gasoline and unleaded gasoline, and polluted soils were analyzed for their Pb content and isotope ratio and compared to those observed in PM 10 samples. Airborne Pb concentration ranged from 167 to 854 ng/m 3 in the seven monitored sites with an average of 515 ng/m 3 in Shanghai, indicating that a high concentration of Pb remains in the air after the phasing out of leaded gasoline. Lead isotopic compositions in airborne particles ( 207Pb/ 206Pb, 0.8608±0.0018; 208Pb/ 206Pb, 2.105±0.005) are clearly distinct from the vehicle exhaust particles ( 207Pb/ 206Pb, 0.8854±0.0075; 208Pb/ 206Pb, 2.145±0.006), suggesting that the automotive lead is not currently the major component of Pb in the air. By using a binary mixing equation, a source apportionment based on 207Pb/ 206Pb ratios, indicates that the contribution from automotive emission to the airborne Pb is around 20%. The Pb isotope ratios obtained in the source-related samples confirmed that the major emission sources are metallurgic dust, coal combustion, and cement.

The 2017 Nobel Prize in Chemistry: cryo-EM comes of age.

Science.gov (United States)

Shen, Peter S

2018-03-01

The 2017 Nobel Prize in Chemistry was awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson for "developing cryo-electron microscopy (cryo-EM) for the high-resolution structure determination of biomolecules in solution." This feature article summarizes some of the major achievements leading to the development of cryo-EM and recent technological breakthroughs that have transformed the method into a mainstream tool for structure determination.

Neuron-derived IgG protects neurons from complement-dependent cytotoxicity.

Science.gov (United States)

Zhang, Jie; Niu, Na; Li, Bingjie; McNutt, Michael A

2013-12-01

Passive immunity of the nervous system has traditionally been thought to be predominantly due to the blood-brain barrier. This concept must now be revisited based on the existence of neuron-derived IgG. The conventional concept is that IgG is produced solely by mature B lymphocytes, but it has now been found to be synthesized by murine and human neurons. However, the function of this endogenous IgG is poorly understood. In this study, we confirm IgG production by rat cortical neurons at the protein and mRNA levels, with 69.0 ± 5.8% of cortical neurons IgG-positive. Injury to primary-culture neurons was induced by complement leading to increases in IgG production. Blockage of neuron-derived IgG resulted in more neuronal death and early apoptosis in the presence of complement. In addition, FcγRI was found in microglia and astrocytes. Expression of FcγR I in microglia was increased by exposure to neuron-derived IgG. Release of NO from microglia triggered by complement was attenuated by neuron-derived IgG, and this attenuation could be reversed by IgG neutralization. These data demonstrate that neuron-derived IgG is protective of neurons against injury induced by complement and microglial activation. IgG appears to play an important role in maintaining the stability of the nervous system.

Melatonin reduces lead levels in blood, brain and bone and increases lead excretion in rats subjected to subacute lead treatment.

Science.gov (United States)

Hernández-Plata, Everardo; Quiroz-Compeán, Fátima; Ramírez-Garcia, Gonzalo; Barrientos, Eunice Yáñez; Rodríguez-Morales, Nadia M; Flores, Alberto; Wrobel, Katarzina; Wrobel, Kazimierz; Méndez, Isabel; Díaz-Muñoz, Mauricio; Robles, Juvencio; Martínez-Alfaro, Minerva

2015-03-04

Melatonin, a hormone known for its effects on free radical scavenging and antioxidant activity, can reduce lead toxicity in vivo and in vitro.We examined the effects of melatonin on lead bio-distribution. Rats were intraperitoneally injected with lead acetate (10, 15 or 20mg/kg/day) with or without melatonin (10mg/kg/day) daily for 10 days. In rats intoxicated with the highest lead doses, those treated with melatonin had lower lead levels in blood and higher levels in urine and feces than those treated with lead alone, suggesting that melatonin increases lead excretion. To explore the mechanism underlying this effect, we first assessed whether lead/melatonin complexes were formed directly. Electronic density functional (DFT) calculations showed that a lead/melatonin complex is energetically feasible; however, UV spectroscopy and NMR analysis showed no evidence of such complexes. Next, we examined the liver mRNA levels of metallothioneins (MT) 1 and 2. Melatonin cotreatment increased the MT2 mRNA expression in the liver of rats that received the highest doses of lead. The potential effects of MTs on the tissue distribution and excretion of lead are not well understood. This is the first report to suggest that melatonin directly affects lead levels in organisms exposed to subacute lead intoxication. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Thermodynamic derivation of Saha's equation for a multi-temperature plasma

International Nuclear Information System (INIS)

Morro, Angelo; Romeo, Maurizio

1988-01-01

The ionization equilibrium between the constituents of a multi-temperature plasma is investigated within the thermodynamics of fluid mixtures. As a result, a law of mass action is derived that, in the approximation of ideal gases for the constituents, leads to a direct generalization of Saha's equation. The main properties of this generalization are discussed, and contrasted with those of other equations which have appeared in the literature. (author)

Derivatives of Dictyostelium differentiation-inducing factors inhibit lysophosphatidic acid–stimulated migration of murine osteosarcoma LM8 cells

Energy Technology Data Exchange (ETDEWEB)

Kubohara, Yuzuru, E-mail: ykuboha@juntendo.ac.jp [Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation (IMCR), Gunma University, Maebashi 371-8512 (Japan); Department of Health Science, Juntendo University Graduate School of Health and Sports Science, Inzai 270-1695 (Japan); Komachi, Mayumi [Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation (IMCR), Gunma University, Maebashi 371-8512 (Japan); Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi 371-8511 (Japan); Homma, Yoshimi [Department of Biomolecular Science, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295 (Japan); Kikuchi, Haruhisa; Oshima, Yoshiteru [Laboratory of Natural Product Chemistry, Tohoku University Graduate School of Pharmaceutical Sciences, Aoba-yama, Aoba-ku, Sendai 980-8578 (Japan)

2015-08-07

Osteosarcoma is a common metastatic bone cancer that predominantly develops in children and adolescents. Metastatic osteosarcoma remains associated with a poor prognosis; therefore, more effective anti-metastatic drugs are needed. Differentiation-inducing factor-1 (DIF-1), −2, and −3 are novel lead anti-tumor agents that were originally isolated from the cellular slime mold Dictyostelium discoideum. Here we investigated the effects of a panel of DIF derivatives on lysophosphatidic acid (LPA)-induced migration of mouse osteosarcoma LM8 cells by using a Boyden chamber assay. Some DIF derivatives such as Br-DIF-1, DIF-3(+2), and Bu-DIF-3 (5–20 μM) dose-dependently suppressed LPA-induced cell migration with associated IC{sub 50} values of 5.5, 4.6, and 4.2 μM, respectively. On the other hand, the IC{sub 50} values of Br-DIF-1, DIF-3(+2), and Bu-DIF-3 versus cell proliferation were 18.5, 7.2, and 2.0 μM, respectively, in LM8 cells, and >20, 14.8, and 4.3 μM, respectively, in mouse 3T3-L1 fibroblasts (non-transformed). Together, our results demonstrate that Br-DIF-1 in particular may be a valuable tool for the analysis of cancer cell migration, and that DIF derivatives such as DIF-3(+2) and Bu-DIF-3 are promising lead anti-tumor agents for the development of therapies that suppress osteosarcoma cell proliferation, migration, and metastasis. - Highlights: • LPA induces cell migration (invasion) in murine osteosarcoma LM8 cells. • DIFs are novel lead anti-tumor agents found in Dictyostelium discoideum. • We examined the effects of DIF derivatives on LPA-induced LM8 cell migration in vitro. • Some of the DIF derivatives inhibited LPA-induced LM8 cell migration.

Cryogenic current leads

Energy Technology Data Exchange (ETDEWEB)

Zizek, F.

1982-01-01

Theoretical, technical and design questions are examined of cryogenic current leads for SP of magnetic systems. Simplified mathematical models are presented for the current leads. To illustrate modeling, the calculation is made of the real current leads for 500 A and three variants of current leads for 1500 A for the enterprise ''Shkoda.''

The effect of lead-based paint hazard remediation on blood lead levels of lead poisoned children in New York City

International Nuclear Information System (INIS)

Leighton, Jessica; Klitzman, Susan; Sedlar, Slavenka; Matte, Thomas; Cohen, Neal L.

2003-01-01

Despite the widespread use of lead paint hazard control for children with lead poisoning, few controlled studies that estimate the effect of such control on children's blood lead levels have been published. This retrospective follow-up study examined the effects of lead hazard remediation and its timing on the blood lead levels of lead-poisoned children. From the New York City child blood lead registry, 221 children were selected who had an initial blood lead level of 20-44 μg/dL between 1 July 1994 and 31 December 1996; were 6 months to 6 years of age; had a report of a follow-up blood lead test between 10 and 14 months after the initial test; had a lead-based paint hazard identified in the primary dwelling unit prior to the 10- to 14-month follow-up blood lead test; had resided or spent time at only one address with an identified lead-based paint hazard; and were not chelated. The decline in geometric mean blood lead levels from baseline to 10-14 months later was compared for children whose homes were remediated and whose homes were not remediated during the follow-up period. Regardless of remediation, geometric mean blood lead levels declined significantly from 24.3 μg/dL at the initial diagnosis to 12.3 μg/dL at the 10- to 14-month follow-up blood lead test (P<0.01). Among the 146 children whose homes were remediated the geometric mean blood lead levels declined 53% compared to 41% among the 75 children whose homes were not remediated by the follow-up blood lead test, a remediation effect of approximately 20% (P<0.01). After adjusting for potential confounders, the remediation effect was 11%, although it was no longer significant. Race was the only factor that appeared to confound the relationship: Black children had higher follow-up blood lead levels even after controlling for other factors, including the natural logarithm of the initial blood lead level. The effect of remediation appeared to be stronger for younger (10 to <36 months old) than for older (36

Work function of oxygen exposed lead and lead/indium alloy films

International Nuclear Information System (INIS)

Gundlach, K.H.; Hellemann, H.P.; Hoelzl, J.

1982-01-01

The effect of indium in superconducting tunnel junctions with lead/indium alloy base electrodes is investigated by measuring the vacuum work function of lead, indium, and lead/indium alloy films. It is found that the anomalous decrease of the work function of lead upon exposure to oxygen, explained by the penetration of oxygen into the inner surface of the lead film, is reversed into a slight increase in work function when some indium is added to the lead. This result indicates that the addition of indium provides a protection by suppressing the penetration of oxygen (and probably other gases) into the interior of the thin film

Functions of Müller cell-derived vascular endothelial growthfactor in diabetic retinopathy

Institute of Scientific and Technical Information of China (English)

2015-01-01

Müller cells are macroglia and play many essentialroles as supporting cells in the retina. To respond topathological changes in diabetic retinopathy （DR）, amajor complication in the eye of diabetic patients,retinal Müller glia produce a high level of vascularendothelial growth factor （VEGF or VEGF-A）. As VEGFis expressed by multiple retinal cell-types and Müllerglia comprise only a small portion of cells in the retina,it has been a great challenge to reveal the function ofVEGF or other globally expressed proteins produced byMüller cells. With the development of conditional genetargeting tools, it is now possible to dissect the functionof Müller cell-derived VEGF in vivo . By using conditionalgene targeting approach, we demonstrate that Müllerglia are a major source of retinal VEGF in diabetic miceand Müller cell-derived VEGF plays a significant role inthe alteration of protein expression and peroxynitration,which leads to retinal inflammation, neovascularization,vascular leakage, and vascular lesion, key pathologicalchanges in DR. Therefore, Müller glia are a potentialcellular target for the treatment of DR, a leading causeof blindness.

Blood lead and lead-210 origins in residents of Toulouse

International Nuclear Information System (INIS)

Servant, J.; Delapart, M.

1981-01-01

Blood lead and lead-210 analyses were performed on blood samples from non-smoking residents of Toulouse (city of 400,000 inhabitants). Simultaneous surface soil lead content determinations were carried out by the same procedure on rural zone samples of southwestern France. The observed isotopic ratios were compared in order to evaluate food chain contamination. For an average of 19.7 +- 5.8 μg 100 cc -1 of lead in blood, atmospheric contamination amounts to 20%, estimated as follows: 6% from direct inhalation and 14% from dry deposits on vegetation absorbed as food. The natural levels carried over by the food chain reach 14.9 μg 100 cc -1 and have a 210 Pb/Pb concentration ratio of 0.055 dpmμg -1 . These results lead to a maximum value of 15 μg 100 cc -1 for natural lead in human blood according to the ICRP model. (author)

Lead-Free Piezoelectrics

CERN Document Server

Nahm, Sahn

2012-01-01

Ecological restrictions in many parts of the world are demanding the elimination of Pb from all consumer items. At this moment in the piezoelectric ceramics industry, there is no issue of more importance than the transition to lead-free materials. The goal of Lead-Free Piezoelectrics is to provide a comprehensive overview of the fundamentals and developments in the field of lead-free materials and products to leading researchers in the world. The text presents chapters on demonstrated applications of the lead-free materials, which will allow readers to conceptualize the present possibilities and will be useful for both students and professionals conducting research on ferroelectrics, piezoelectrics, smart materials, lead-free materials, and a variety of applications including sensors, actuators, ultrasonic transducers and energy harvesters.

Evaluation of neutron and gamma-ray-production cross-section data for lead

International Nuclear Information System (INIS)

Fu, C.Y.; Perey, F.G.

1975-01-01

A survey was made of the available information on neutron and gamma-ray-production cross-section measurements of lead. From these and from relevant nuclear-structure information on the Pb isotopes, recommended neutron cross-section data sets for lead covering the neutron energy range from 0.00001 eV to 20.0 MeV have been prepared. The cross sections are derived from experimental results available to February 1972 and from calculations based on optical-model, DWBA, and Hauser--Feshbach theories. Comparisons which show good agreement between theoretical and experimental values are displayed in a number of graphs. Also presented graphically are smoothed total cross sections, Legendre coefficients for angular distributions, and a representative energy distribution of gamma rays from resonance capture. 15 tables, 36 figures, 104 references

Lead Toxicity

Science.gov (United States)

... o Do not use glazed ceramics, home remedies, cosmetics, or leaded-crystal glassware unless you know that they are lead safe. o If you live near an industry, mine, or waste site that may have contaminated ...

On the derivation of the ionisation threshold law

International Nuclear Information System (INIS)

Peterkop, R.

1983-01-01

The different procedures for derivation of the electron-atom ionisation threshold law have been analysed and the reasons for discrepancies in the results are pointed out. It is shown that if the wavefunction has a linear node at equal electron distances (r 1 =r 2 ), then the threshold law for the total cross section has the form σ approx. Esup(3m), where σ approx. Esup(m) is the Wannier law. The distribution of energy between escaping electrons is non-uniform and has a parabolic node at equal energies (epsilon 1 = epsilon 2 ). The linear node at opposite directions of electrons (theta = π) does not change the Wannier law but leads to a parabolic node in angular distribution at theta = π. The existence of both nodes leads to the threshold law σ approx. Esup(3m) and to parabolic nodes in energy and angular distributions. (author)

Radiogenic Lead Isotopes and Time Stratigraphy in the Hudson River, New York

International Nuclear Information System (INIS)

Chillrud, Steven N.; Bopp, Richard F.; Ross, James M.; Chaky, Damon A.; Hemming, Sidney; Shuster, Edward L.; Simpson, H. James; Estabrooks, Frank

2004-01-01

Radionuclide, radiogenic lead isotope and trace metal analyses on fine-grained sediment cores collected along 160 km of the upper and tidal Hudson River were used to examine temporal trends of contaminant loadings and to develop radiogenic lead isotopes both as a stratigraphic tool and as tracers for resolving decadal particle transport fluxes. Very large inputs of Cd, Sb, Pb, and Cr are evident in the sediment record, potentially from a single manufacturing facility. The total range in radiogenic lead isotope ratios observed in well-dated cores collected about 24 km downstream of the plant is large (e.g., maximum difference in 206 Pb/ 207 Pb is 10%), characterized by four major shifts occurring in the 1950s, 1960s, 1970s and 1980s. The upper Hudson signals in Cd and radiogenic lead isotopes were still evident in sediments collected 160 km downstream in the tidal Hudson. The large magnitude and abrupt shifts in radiogenic lead isotope ratios as a function of depth provide sensitive temporal constraints that complement information derived from radionuclide analyses to significantly improve the precision of dating assignments. Application of a simple dilution model to data from paired cores suggests much larger sediment inputs in one section of the river than previously reported, suggesting particle influxes to the Hudson have been underestimated

Role of pigment epithelium-derived factor in the involution of hemangioma: Autocrine growth inhibition of hemangioma-derived endothelial cells

Energy Technology Data Exchange (ETDEWEB)

Kim, Kyung-Jin [Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799 (Korea, Republic of); Department of Biomedical Science, College of Medicine, Seoul National University, Seoul 110-799 (Korea, Republic of); Yun, Jang-Hyuk; Heo, Jong-Ik [Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799 (Korea, Republic of); Lee, Eun Hui [Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 137-701 (Korea, Republic of); Min, Hye Sook [Department of Pathology, Seoul National University Hospital, Seoul 110-744 (Korea, Republic of); Choi, Tae Hyun, E-mail: psthchoi@snu.ac.kr [Department of Plastic and Reconstructive Surgery, Seoul National University Children’s Hospital, Seoul 110-744 (Korea, Republic of); Department of Pediatric Plastic and Reconstructive Surgery, Seoul National University Children’s Hospital, Seoul 110-744 (Korea, Republic of); Cho, Chung-Hyun, E-mail: iamhyun@snu.ac.kr [Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799 (Korea, Republic of); Department of Biomedical Science, College of Medicine, Seoul National University, Seoul 110-799 (Korea, Republic of); Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University, Seoul 110-799 (Korea, Republic of); Cancer Research Institute, College of Medicine, Seoul National University, Seoul 110-799 (Korea, Republic of)

2014-11-14

Highlights: • PEDF was expressed and induced during the involuting phase of IH. • PEDF inhibited the cell growth of the involuting HemECs in an autocrine manner. • PEDF suppression restored the impaired cell growth of the involuting HemECs. - Abstract: Hemangioma is a benign tumor derived from abnormal blood vessel growth. Unlike other vascular tumor counterparts, a hemangioma is known to proliferate during its early stage but it is followed by a stage of involution where regression of the tumor occurs. The critical onset leading to the involution of hemangioma is currently not well understood. This study focused on the molecular identities of the involution of hemangioma. We demonstrated that a soluble factor released from the involuting phase of hemangioma-derived endothelial cells (HemECs) and identified pigment epithelium-derived factor (PEDF) as an anti-angiogenic factor that was associated with the growth inhibition of the involuting HemECs. The growth inhibition of the involuting HemECs was reversed by suppression of PEDF in the involuting HemECs. Furthermore, we found that PEDF was more up-regulated in the involuting phase of hemangioma tissues than in the proliferating or the involuted. Taken together, we propose that PEDF accelerates the involution of hemangioma by growth inhibition of HemECs in an autocrine manner. The regulatory mechanism of PEDF expression could be a potential therapeutic target to treat hemangiomas.

High-precision Pb isotopic measurements of teeth and environmental samples from Sofia (Bulgaria): insights for regional lead sources and possible pathways to the human body

Science.gov (United States)

Kamenov, George D.

2008-08-01

High-precision Pb isotopic measurements on teeth and possible sources in a given area can provide important insights for the lead (Pb) sources and pathways in the human body. Pb isotopic analyses on soils from the area of Sofia, Bulgaria show that Pb is contributed by three end-members represented by two natural sources and leaded gasoline. Sequential leaching experiments reveal that the alumosilicate fraction of the soils is mainly controlled by natural Pb derived from two mountain massifs bordering the city. Around 1/3 to a half of the Pb in the soil leachates, however, can be explained by contamination from leaded gasoline. Contemporary teeth from Sofia residents show very similar Pb isotopic compositions to the soil leachates, also indicating that around 1/3 to a half of the Pb can be explained by derivation from leaded gasoline. The remarkable isotopic similarities between the teeth and the most labile fractions of the local soils suggest that the lead can be derived from the latter. Pb incorporation in the human body via soil-plant-human or soil-plant-animal-human chains is unlikely due to the fact that no significant farming occurs in the city area. The isotopic compositions of the local soil labile fractions can be used as approximation of the bioaccessible lead for humans. Considering all possible scenarios it appears that soil and/or soil-born dust inhalation and/or ingestion is the most probable pathway for incorporation of local soil lead in the local population. The high-precision Pb isotope data presented in this work indicate that apparently the local soil is what plays major role in the human Pb exposure.

Weyl Ordering Operator Formula Derived by IWOP Technique and Its Application for Fresnel Operator

International Nuclear Information System (INIS)

Fan Hongyi; Hu Liyun

2009-01-01

Based on the technique of integration within an ordered product of operators, the Weyl ordering operator formula is derived and the Fresnel operators' Weyl ordering is also obtained, which together with the Weyl transformation can immediately lead to Fresnel transformation kernel in classical optics. (general)

The lead and lead-acid battery industries during 2002 and 2007 in China

Energy Technology Data Exchange (ETDEWEB)

Chen, H.Y.; Li, A.J.; Finlow, D.E. [Key Lab of Electrochemical Technology on Energy Storage and Power Generation in Guangdong Universities, School of Chemistry and Environment, South China Normal University, Guangzhou 510006 (China)

2009-06-01

In the past 15 years, the center of the international lead market has shifted to China. China has become the largest producer of raw and refined lead, plus the largest consumer. This paper reviews the status of the lead and lead-acid battery industries in China, including lead mining, lead refining, secondary lead production, the lead-acid battery industry, new opportunities for lead-acid batteries, and the environmental problems associated with lead and lead-acid batteries. The output of raw and refined lead has increased annually in China, and now accounts for more than 30% of the world total. As a result of a change in the Chinese government's policy regarding the export of lead, plus an increase in the price of lead, the profits of Chinese lead manufacturers were significantly reduced, the trade deficit of the Chinese lead industry increased, the operating rates of lead smelter enterprises greatly reduced, and some small enterprises were forced to shut down. At the present time, an increasing number of enterprises have begun to produce secondary lead, and the scale of production has expanded from tens of tons to tens of thousands of tons. In 2006, the output of secondary lead in China reached 700,000 tons, but outdated technology and equipment limited development of the secondary lead industry. Because of serious pollution problems, raw material shortages, and fierce price competition in the battery market, changes in the development of the lead-acid battery industry have been dramatic; approximately one thousand medium-sized and small lead-acid battery producers have been closed in the past 3 years. The output of large lead-acid battery enterprises has not been reduced, however, as a result of their manufacturing technology and equipment being comparable to those in other advanced industrial countries. In China, the flourishing development of electric bicycles, electric tricycles, and photovoltaic energy systems should provide ongoing opportunities for

The lead and lead-acid battery industries during 2002 and 2007 in China

International Nuclear Information System (INIS)

Chen, H.Y.; Li, A.J.; Finlow, D.E.

2009-01-01

In the past 15 years, the center of the international lead market has shifted to China. China has become the largest producer of raw and refined lead, plus the largest consumer. This paper reviews the status of the lead and lead-acid battery industries in China, including lead mining, lead refining, secondary lead production, the lead-acid battery industry, new opportunities for lead-acid batteries, and the environmental problems associated with lead and lead-acid batteries. The output of raw and refined lead has increased annually in China, and now accounts for more than 30% of the world total. As a result of a change in the Chinese government's policy regarding the export of lead, plus an increase in the price of lead, the profits of Chinese lead manufacturers were significantly reduced, the trade deficit of the Chinese lead industry increased, the operating rates of lead smelter enterprises greatly reduced, and some small enterprises were forced to shut down. At the present time, an increasing number of enterprises have begun to produce secondary lead, and the scale of production has expanded from tens of tons to tens of thousands of tons. In 2006, the output of secondary lead in China reached 700,000 tons, but outdated technology and equipment limited development of the secondary lead industry. Because of serious pollution problems, raw material shortages, and fierce price competition in the battery market, changes in the development of the lead-acid battery industry have been dramatic; approximately one thousand medium-sized and small lead-acid battery producers have been closed in the past 3 years. The output of large lead-acid battery enterprises has not been reduced, however, as a result of their manufacturing technology and equipment being comparable to those in other advanced industrial countries. In China, the flourishing development of electric bicycles, electric tricycles, and photovoltaic energy systems should provide ongoing opportunities for the

The history and recent advances in research of polyprenol and its derivatives.

Science.gov (United States)

Sagami, Hiroshi; Swiezewska, Ewa; Shidoji, Yoshihiro

2018-01-03

The reduction pathway leading to the formation of dolichol was clarified in 2010 with the identification of SRD5A3, which is the polyprenol reductase. The finding inspired us to reanalyze the length of the major chain of polyprenol and dolichol from several plant leaves, including mangrove plants, as well as from animal and fish livers by 2D-TLC. Polyprenol- and dolichol-derived metabolites such as polyprenylacetone and epoxydolichol were found together with rubber-like prenol. This review focuses on analyses of polyprenol and its derivatives, including recently found epoxypolyprenol and polyprenylacetone. Attention has also been paid to the chromatographic behavior of rubber-like prenol on TLC.

A green lead hydrometallurgical process based on a hydrogen-lead oxide fuel cell.

Science.gov (United States)

Pan, Junqing; Sun, Yanzhi; Li, Wei; Knight, James; Manthiram, Arumugam

2013-01-01

The automobile industry consumed 9 million metric tons of lead in 2012 for lead-acid batteries. Recycling lead from spent lead-acid batteries is not only related to the sustainable development of the lead industry, but also to the reduction of lead pollution in the environment. The existing lead pyrometallurgical processes have two main issues, toxic lead emission into the environment and high energy consumption; the developing hydrometallurgical processes have the disadvantages of high electricity consumption, use of toxic chemicals and severe corrosion of metallic components. Here we demonstrate a new green hydrometallurgical process to recover lead based on a hydrogen-lead oxide fuel cell. High-purity lead, along with electricity, is produced with only water as the by-product. It has a >99.5% lead yield, which is higher than that of the existing pyrometallurgical processes (95-97%). This greatly reduces lead pollution to the environment.

Lead Contamination and Microbial Lead Tolerance in Soils at Major ...

African Journals Online (AJOL)

Devika

ABSTRACT: Lead pollution and lead tolerance levels of microbes in soil at major road junctions in Benin. City were investigated. Results revealed that distance from the road junctions affected the concentrations of lead in soil, as well as the microbial population density and types of microbes present in the soil. The highest ...

Lead Contamination and Microbial Lead Tolerance in Soils at Major ...

African Journals Online (AJOL)

Lead pollution and lead tolerance levels of microbes in soil at major road junctions in Benin City were investigated. Results revealed that distance from the road junctions affected the concentrations of lead in soil, as well as the microbial population density and types of microbes present in the soil. The highest concentrations ...

The effects of thiamin on lead metabolism: organ distribution of lead 203.

Science.gov (United States)

Kim, J S; Hamilton, D L; Blakley, B R; Rousseaux, C G

1992-01-01

The effect of thiamin on the organ distribution of lead was evaluated in CD-1 mice exposed intragastrically or intraperitoneally to a single dose of lead acetate (100 micrograms) containing 100 microCi lead 203. They were treated with either thiamin (25 or 50 mg/kg body weight), calcium ethylenediaminetetraacetic acid (CaEDTA) (50 mg/kg body weight), or combinations of thiamin and CaEDTA. The whole body retention and the organ distribution of lead 203 varied depending upon the route of lead administration, dose of thiamin and the specific treatment combination. Thiamin (25 or 50 mg/kg) treatment increased the whole body retention of both intragastric and intraperitoneal lead by approximately 10% in each instance. Calcium ethylenediaminetetraacetic acid, either alone or in combination with thiamin (50 mg/kg) reduced the whole body retention of lead by as much as 14% regardless of route of lead exposure. The relative retention of lead by the liver, kidney and spleen was greater in mice exposed to lead by the intragastric route. Regardless of route, CaEDTA in the combined treatment reduced the relative retention of lead in both the liver and kidney, whereas thiamin alone only reduced the retention of lead in the kidney. The results of this study indicate that thiamin in combination with CaEDTA alters the distribution and retention of lead in a manner which may have therapeutic application as it relates to chelation therapy. PMID:1423063

Managerial functions of organizing and leading people in MLM organizations and their manifestations in historical schools of managerial thinking

OpenAIRE

Košnarová, Zita

2013-01-01

The article looks into managerial functions of organizing and leading in multilevel marketing (MLM) organizations, focusing on the creation of organizational structures and the style of leadership. Paper is trying to identify what historical trends of managerial thinking these functions are derived from and what other trends influenced them. The functions are studied in a concrete MLM organization in which the organizational structure and the style of leading people are defined. The article d...

Microwave-assisted synthesis and antioxidant properties of hydrazinyl thiazolyl coumarin derivatives

Directory of Open Access Journals (Sweden)

Osman Hasnah

2012-04-01

Full Text Available Abstract Background Coumarin derivatives exhibit a wide range of biological properties including promising antioxidant activity. Furthermore, microwave-assisted organic synthesis has delivered rapid routes to N- and O-containing heterocycles, including coumarins and thiazoles. Combining these features, the use of microwave-assisted processes will provide rapid access to a targeted coumarin library bearing a hydrazino pharmacophore for evaluation of antioxidant properties Results Microwave irradiation promoted 3 of the 4 steps in a rapid, convergent synthesis of a small library of hydrazinyl thiazolyl coumarin derivatives, all of which exhibited significant antioxidant activity comparable to that of the natural antioxidant quercetin, as established by DPPH and ABTS radical assays Conclusions Microwave dielectric heating provides a rapid and expedient route to a series of hydrazinyl thiazolyl coumarins to investigate their radical scavenging properties. Given their favourable properties, in comparison with known antioxidants, these coumarin derivatives are promising leads for further development and optimization.

Excretion of purine base derivatives after intake of bacterial protein meal in pigs

DEFF Research Database (Denmark)

Hellwing, Anne Louise Frydendahl; Tauson, Anne-Helene; Skrede, A.

2007-01-01

Bacterial protein meal has a high content ofprotein but also of RNA and DNA. Sixteen barrows were allocated to four diets containing increasing levels of bacterial protein meal (BPM), from weaning to 80 kg live weight, to evaluate whether the RNA and DNA contents of BPM influenced the retention...... of nitrogen. It was hypothesised that an increased intake of RNA and DNA would lead to an increased urinary excretion of purine base derivatives and increased plasma concentrations. Retention of nitrogen was unaffected by dietary content of BPM (P=0.08) and the urinary excretion of purine base derivatives...

Lead shot from hunting as a source of lead in human blood

International Nuclear Information System (INIS)

Johansen, Poul; Pedersen, Henning Sloth; Asmund, Gert; Riget, Frank

2006-01-01

This study investigates the relationship between the intake of birds hunted with lead shot and the lead concentration in human blood. Fifty adult men from Nuuk, Greenland took part in the study. From September 2003 to June 2004 they regularly gave blood samples and recorded how many birds they ate. We found a clear relationship between the number of bird meals and blood lead and also a clear seasonal variation. The concentration was highest in mid-winter when bird consumption is at its highest. Blood lead was low (15 μg/L, mean concentration) among the participants reporting not eating birds. Among those reporting to eat birds regularly, blood lead was significantly higher, up to 128 μg/L (mean concentration). Concentrations depended on the frequency of bird meals: the more the bird meals, the higher the resulting blood lead. This clear relationship points to lead shot as the dominating lead source to people in Greenland. - Birds hunted with lead shot and consumed are a source of lead in human blood

Lead shot from hunting as a source of lead in human blood

Energy Technology Data Exchange (ETDEWEB)

Johansen, Poul [National Environmental Research Institute, Frederiksborgvej 399, DK-4000 Roskilde (Denmark)]. E-mail: poj@dmu.dk; Pedersen, Henning Sloth [Primary Health Care Center, DK-3900 Nuuk (Greenland); Asmund, Gert [National Environmental Research Institute, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Riget, Frank [National Environmental Research Institute, Frederiksborgvej 399, DK-4000 Roskilde (Denmark)

2006-07-15

This study investigates the relationship between the intake of birds hunted with lead shot and the lead concentration in human blood. Fifty adult men from Nuuk, Greenland took part in the study. From September 2003 to June 2004 they regularly gave blood samples and recorded how many birds they ate. We found a clear relationship between the number of bird meals and blood lead and also a clear seasonal variation. The concentration was highest in mid-winter when bird consumption is at its highest. Blood lead was low (15 {mu}g/L, mean concentration) among the participants reporting not eating birds. Among those reporting to eat birds regularly, blood lead was significantly higher, up to 128 {mu}g/L (mean concentration). Concentrations depended on the frequency of bird meals: the more the bird meals, the higher the resulting blood lead. This clear relationship points to lead shot as the dominating lead source to people in Greenland. - Birds hunted with lead shot and consumed are a source of lead in human blood.

Looking at the work of Raul Lino, in comparison with Frank Lloyd Wright: from the Arts & Crafts, the nature, the organic and the house

Directory of Open Access Journals (Sweden)

José Manuel Fernandes

2016-11-01

Full Text Available El texto hace un análisis comparativo de las obras de Raul Lino (1879-1974, portugués, y Frank Lloyd Wright (1867-1959, de Estados Unidos- dos arquitectos (casi contemporáneos, cada uno exponente de la cultura y la sociedad de su tiempo y de su espacio de vida y de trabajo.El artículo se refiere al contexto histórico y cultural del primer periodo creativo de estos autores. En este contexto trata de las obras de John Ruskin y William Morris, creadores del Arts & Crafts, así como de las características de este movimiento artístico, de las peculiaridades del Deutscher Werkbund y de los trabajos de Sullivan y Berlage. Acerca de Lino y Wright, este artículo presenta la “comprensión del mundo” que tenían: sus temas conceptuales y arquitectónicos, así como los movimientos estéticos y culturales asociados a sus trabajos - “Casa Portuguesa” y “Arquitectura Orgánica”. Se exponen y analizan los “seis principios” de Wright y los “seis principios” de Lino -destacando los aspectos comunes de las concepciones de ambos autores. Se describen y ejemplifican, también, algunos de los temas y materiales arquitectónicos comunes en la primera fase de las obras los arquitectos. Así mismo, se estudia con mayor profundidad el diseño de obras concretas, casas, de su autoría, en sus similitudes y contrastes.

Innovation Management, Lead Users and Social Media

DEFF Research Database (Denmark)

Ernst, M.; Brem, Alexander; Voigt, K.-I.

2013-01-01

Purpose — With the rise of social media, the practice of innovation management is changing rapidly as well. While the opening up of corporate innovation processes can be observed in literature as well as in practice (commonly known as “Open Innovation”), we draw the reader’s attention...... to the strategic potential of social media in innovation management. For this, a conceptual framework will be introduced. Design/methodology/approach — In this chapter, we compare established concepts of knowledge management to potentials of social media in this field, which offer more efficient and promising ways...... social media applications is developed and introduced. Originality/value — The unique conceptual framework derived in this chapter is enriched with a discussion of the challenges resulting from the implementation of Lead-User integration along with social media in corporate innovation management...

The leaching of lead from lead-based paint in landfill environments.

Science.gov (United States)

Wadanambi, Lakmini; Dubey, Brajesh; Townsend, Timothy

2008-08-30

Lead leaching from lead-based paint (LBP) was examined using standardized laboratory protocols and tests with leachate from actual and simulated landfill environments. Two different LBP samples were tested; leaching solutions included leachates from three municipal solid waste (MSW) landfills and three construction and demolition (C&D) debris landfills. The toxicity characteristic leaching procedure (TCLP) and the synthetic precipitation leaching procedure (SPLP) were also performed. Lead concentrations were many times higher using the TCLP compared to the SPLP and the landfill leachates. No significant difference (alpha=0.05) was observed in leached lead concentrations from the MSW landfill and C&D debris landfill leachates. The impact of other building materials present in LBP debris on lead leaching was examined by testing mixtures of LBP (2%) and different building materials (98%; steel, wood, drywall, concrete). The type of substrate present impacted lead leaching results, with concrete demonstrating the most dramatic impact; the lowest lead concentrations were measured in the presence of concrete under both TCLP and SPLP extractions.

Leading temperature dependence of the conductance in Kondo-correlated quantum dots

Science.gov (United States)

Aligia, A. A.

2018-04-01

Using renormalized perturbation theory in the Coulomb repulsion, we derive an analytical expression for the leading term in the temperature dependence of the conductance through a quantum dot described by the impurity Anderson model, in terms of the renormalized parameters of the model. Taking these parameters from the literature, we compare the results with published ones calculated using the numerical renormalization group obtaining a very good agreement. The approach is superior to alternative perturbative treatments. We compare in particular to the results of a simple interpolative perturbation approach.

Relationship between soil lead and airborne lead concentrations at Springfield, Missouri, USA

Energy Technology Data Exchange (ETDEWEB)

Sheets, R W; Kyger, J R; Biagioni, R N; Probst, S [Department of Chemistry, Southwest Missouri State University, 65804 Springfield, MO (United States); Boyer, R; Barke, K [Greene County Health Department, 65802 Springfield, MO (United States)

2001-04-23

This study tests whether lead deposited to soil from automobiles during past years in a medium-sized US city (population 150000) may present a current health risk. It examines the relationship between current soil lead concentrations at nine locations within the city of Springfield, Missouri, and airborne lead levels measured at the same locations during years (1975-1981) when lead emissions from automobiles were much greater than at present. A strong, significant correlation is found between soil and airborne lead levels at eight of the sites (r=0.91, P<0.005 for soil lead vs. 1979 airborne lead), in low-traffic areas as well as in areas adjacent to heavy traffic flow. Residual lead concentrations in these soils are relatively low, even for the high-traffic sites, as expected for a medium sized city.

Corrosion by liquid lead and lead-bismuth: experimental results review and analysis

Energy Technology Data Exchange (ETDEWEB)

Zhang, Jinsuo [Los Alamos National Laboratory

2008-01-01

Liquid metal technologies for liquid lead and lead-bismuth alloy are under wide investigation and development for advanced nuclear energy systems and waste transmutation systems. Material corrosion is one of the main issues studied a lot recently in the development of the liquid metal technology. This study reviews corrosion by liquid lead and lead bismuth, including the corrosion mechanisms, corrosion inhibitor and the formation of the protective oxide layer. The available experimental data are analyzed by using a corrosion model in which the oxidation and scale removal are coupled. Based on the model, long-term behaviors of steels in liquid lead and lead-bismuth are predictable. This report provides information for the selection of structural materials for typical nuclear reactor coolant systems when selecting liquid lead or lead bismuth as heat transfer media.

Relationship between soil lead and airborne lead concentrations at Springfield, Missouri, USA.

Science.gov (United States)

Sheets, R W; Kyger, J R; Biagioni, R N; Probst, S; Boyer, R; Barke, K

2001-04-23

This study tests whether lead deposited to soil from automobiles during past years in a medium-sized US city (population 150,000) may present a current health risk. It examines the relationship between current soil lead concentrations at nine locations within the city of Springfield, Missouri, and airborne lead levels measured at the same locations during years (1975-1981) when lead emissions from automobiles were much greater than at present. A strong, significant correlation is found between soil and airborne lead levels at eight of the sites (r = 0.91, P lead vs. 1979 airborne lead), in low-traffic areas as well as in areas adjacent to heavy traffic flow. Residual lead concentrations in these soils are relatively low, even for the high-traffic sites, as expected for a medium sized city.

Biodistribution, Uptake and Effects Caused by Cancer-Derived Extracellular Vesicles

Directory of Open Access Journals (Sweden)

Lilite Sadovska

2015-03-01

Full Text Available Extracellular vesicles (EVs have recently emerged as important mediators of intercellular communication. They are released in the extracellular space by a variety of normal and cancerous cell types and have been found in all human body fluids. Cancer-derived EVs have been shown to carry lipids, proteins, mRNAs, non-coding and structural RNAs and even extra-chromosomal DNA, which can be taken up by recipient cells and trigger diverse physiological and pathological responses. An increasing body of evidence suggests that cancer-derived EVs mediate paracrine signalling between cancer cells. This leads to the increased invasiveness, proliferation rate and chemoresistance, as well as the acquisition of the cancer stem cell phenotype. This stimulates angiogenesis and the reprogramming of normal stromal cells into cancer-promoting cell types. Furthermore, cancer-derived EVs contribute to the formation of the pre-metastatic niche and modulation of anti-tumour immune response. However, as most of these data are obtained by in vitro studies, it is not entirely clear which of these effects are recapitulated in vivo . In the current review, we summarize studies that assess the tissue distribution, trafficking, clearance and uptake of cancer-derived EVs in vivo and discuss the impact they have, both locally and systemically.

77 FR 8066 - Semiannual Agenda of Regulations

Science.gov (United States)

2012-02-13

... Consumer Protection Act (Dodd-Frank Act). In accordance with the requirements of the Dodd-Frank Act, the... proposed rule that would implement section 619 of the Dodd-Frank Wall Street Reform and Consumer Protection... separated from its parent structure, and to be wound down or resolved in an orderly fashion. The IDI's plan...

Hermes Frank Chidam'modzi

African Journals Online (AJOL)

specifically analyse or discuss Plato's theories of education or justice. 93 .... the world, the unemployment capital of the world, the poverty continent, the Aids .... the masses would be empowered with the necessary civic and political rights.

A review of catalytic hydrodeoxygenation of lignin-derived phenols from biomass pyrolysis.

Science.gov (United States)

Bu, Quan; Lei, Hanwu; Zacher, Alan H; Wang, Lu; Ren, Shoujie; Liang, Jing; Wei, Yi; Liu, Yupeng; Tang, Juming; Zhang, Qin; Ruan, Roger

2012-11-01

Catalytic hydrodeoxygenation (HDO) of lignin-derived phenols which are the lowest reactive chemical compounds in biomass pyrolysis oils has been reviewed. The hydrodeoxygenation (HDO) catalysts have been discussed including traditional HDO catalysts such as CoMo/Al(2)O(3) and NiMo/Al(2)O(3) catalysts and transition metal catalysts (noble metals). The mechanism of HDO of lignin-derived phenols was analyzed on the basis of different model compounds. The kinetics of HDO of different lignin-derived model compounds has been investigated. The diversity of bio-oils leads to the complexities of HDO kinetics. The techno-economic analysis indicates that a series of major technical and economical efforts still have to be investigated in details before scaling up the HDO of lignin-derived phenols in existed refinery infrastructure. Examples of future investigation of HDO include significant challenges of improving catalysts and optimum operation conditions, further understanding of kinetics of complex bio-oils, and the availability of sustainable and cost-effective hydrogen source. Copyright © 2012 Elsevier Ltd. All rights reserved.

Radiation effects on structural materials. Technical progress report, January 1, 1984-June 30, 1984

International Nuclear Information System (INIS)

Ghoneim, N.M.

1984-01-01

By a generalization of an analysis due to Frank of the growing precipitate, we derive an analytic sink strength for the growing void that takes account of the void surface motion in a self-consistent fashion. The lower mobility of the vacancies compared to the interstitials ensures that a growing void captures more vacancies than the usual quasi-static void. The various consequences of this void bias for vacancies are discussed in relation to the swelling of reactor materials

Uranium-lead systematics

International Nuclear Information System (INIS)

Wickman, F.E.

1983-01-01

The method of Levchenkov and Shukolyukov for calculating age and time disturbance of minerals without correction for original lead is generalized to include the cases when (1) original lead and radiogenic lead leach differently, and (2) the crystals studied consist of a core and a mantle. It is also shown that a straight line obtained from the solution of the equations is the locus of the isotopic composition of original lead. (Auth.)

Diesel engine performance and emissions with fuels derived from waste tyres.

Science.gov (United States)

Verma, Puneet; Zare, Ali; Jafari, Mohammad; Bodisco, Timothy A; Rainey, Thomas; Ristovski, Zoran D; Brown, Richard J

2018-02-06

The disposal of waste rubber and scrap tyres is a significant issue globally; disposal into stockpiles and landfill poses a serious threat to the environment, in addition to creating ecological problems. Fuel production from tyre waste could form part of the solution to this global issue. Therefore, this paper studies the potential of fuels derived from waste tyres as alternatives to diesel. Production methods and the influence of reactor operating parameters (such as reactor temperature and catalyst type) on oil yield are outlined. These have a major effect on the performance and emission characteristics of diesel engines when using tyre derived fuels. In general, tyre derived fuels increase the brake specific fuel consumption and decrease the brake thermal efficiency. The majority of studies indicate that NOx emissions increase with waste tyre derived fuels; however, a few studies have reported the opposite trend. A similar increasing trend has been observed for CO and CO 2 emissions. Although most studies reported an increase in HC emission owing to lower cetane number and higher density, some studies have reported reduced HC emissions. It has been found that the higher aromatic content in such fuels can lead to increased particulate matter emissions.

Prospecting for novel plant-derived molecules of Rauvolfia serpentina as inhibitors of Aldose Reductase, a potent drug target for diabetes and its complications.

Directory of Open Access Journals (Sweden)

Shivalika Pathania

Full Text Available Aldose Reductase (AR is implicated in the development of secondary complications of diabetes, providing an interesting target for therapeutic intervention. Extracts of Rauvolfia serpentina, a medicinal plant endemic to the Himalayan mountain range, have been known to be effective in alleviating diabetes and its complications. In this study, we aim to prospect for novel plant-derived inhibitors from R. serpentina and to understand structural basis of their interactions. An extensive library of R. serpentina molecules was compiled and computationally screened for inhibitory action against AR. The stability of complexes, with docked leads, was verified using molecular dynamics simulations. Two structurally distinct plant-derived leads were identified as inhibitors: indobine and indobinine. Further, using these two leads as templates, 16 more leads were identified through ligand-based screening of their structural analogs, from a small molecules database. Thus, we obtained plant-derived indole alkaloids, and their structural analogs, as potential AR inhibitors from a manually curated dataset of R. serpentina molecules. Indole alkaloids reported herein, as a novel structural class unreported hitherto, may provide better insights for designing potential AR inhibitors with improved efficacy and fewer side effects.

Prospecting for novel plant-derived molecules of Rauvolfia serpentina as inhibitors of Aldose Reductase, a potent drug target for diabetes and its complications.

Science.gov (United States)

Pathania, Shivalika; Randhawa, Vinay; Bagler, Ganesh

2013-01-01

Aldose Reductase (AR) is implicated in the development of secondary complications of diabetes, providing an interesting target for therapeutic intervention. Extracts of Rauvolfia serpentina, a medicinal plant endemic to the Himalayan mountain range, have been known to be effective in alleviating diabetes and its complications. In this study, we aim to prospect for novel plant-derived inhibitors from R. serpentina and to understand structural basis of their interactions. An extensive library of R. serpentina molecules was compiled and computationally screened for inhibitory action against AR. The stability of complexes, with docked leads, was verified using molecular dynamics simulations. Two structurally distinct plant-derived leads were identified as inhibitors: indobine and indobinine. Further, using these two leads as templates, 16 more leads were identified through ligand-based screening of their structural analogs, from a small molecules database. Thus, we obtained plant-derived indole alkaloids, and their structural analogs, as potential AR inhibitors from a manually curated dataset of R. serpentina molecules. Indole alkaloids reported herein, as a novel structural class unreported hitherto, may provide better insights for designing potential AR inhibitors with improved efficacy and fewer side effects.

Regional lead isotope study of a polluted river catchment: River Wear, Northern England, UK

International Nuclear Information System (INIS)

Shepherd, Thomas J.; Chenery, Simon R.N.; Pashley, Vanessa; Lord, Richard A.; Ander, Louise E.; Breward, Neil; Hobbs, Susan F.; Horstwood, Matthew; Klinck, Benjamin A.; Worrall, Fred

2009-01-01

High precision, lead isotope analyses of archived stream sediments from the River Wear catchment, northeast England (1986-88), provide evidence for three main sources of anthropogenic lead pollution; lead mining, industrial lead emissions and leaded petrol. In the upper catchment, pollution is totally controlled and dominated by large lead discharges from historic mining centres in the North Pennine Orefield ( 208 Pb/ 206 Pb, 207 Pb/ 206 Pb ratios range from 2.0744-2.0954 and 0.8413-0.8554 respectively). In the lower catchment, co-extensive with the Durham Coalfield and areas of high population density, pollution levels are lower and regionally more uniform. Isotope ratios are systematically higher than in the upper catchment ( 208 Pb/ 206 Pb, 207 Pb/ 206 Pb ratios range from 2.0856-2.1397 and 0.8554-0.8896 respectively) and far exceed values determined for the geogenic regional background. Here, the pollution is characterised by the atmospheric deposition of industrial lead and petrol lead. Lead derived from the combustion of coal, although present, is masked by the other two sources. Recent sediments from the main channel of the River Wear are isotopically indistinguishable from older, low order stream sediments of the North Pennine Orefield, indicating that contamination of the river by lead mining waste (up to several 1000 mg/kg Pb at some locations) continues to pose an environmental problem; a pattern that can be traced all the way to the tidal reach. Using within-catchment isotope variation and sediment lead concentrations, estimates can be made of the discharges from discrete mines or groups of mines to the overall level of lead pollution in the River Wear. As well as providing information pertinent to source apportionment and on-going catchment remediation measures, the database is a valuable resource for epidemiologists concerned with the health risks posed by environmental lead.

Lead dust in Broken Hill homes: effect of remediation on indoor lead levels.

Science.gov (United States)

Boreland, F; Lyle, D M