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Sample records for dense pulmonary opacification

  1. Dense pulmonary opacification in neonates treated with extracorporeal membrane oxygenation

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    Schlesinger, A.E.; Cornish, J.D.; Null, D.M.

    1986-09-01

    Chest radiographic findings in three neonates with respiratory failure secondary to meconium aspiration treated with extracorporeal membrane oxygenation (ECMO) are described. The degree of pulmonary opacification on the chest radiographs failed to correlate with the patients' clinical status as measured by the arterial oxygen levels but correlated well with the peak airway pressure (PAP) and continuous positive airway pressure (CPAP) settings on the mechanical ventilator. Because a variable portion of the arterial blood oxygenation is performed by the extracorporeal membrane oxygenator and unusually large fluctuations in airway pressure settings can occur in these patients while on ECMO, it is important to realize that the chest radiography may not be an accurate predictor of the patients' clinical status.

  2. Data on the quantitative assessment pulmonary ground-glass opacification from coronary computed tomography angiography datasets

    DEFF Research Database (Denmark)

    Kühl, J Tobias; Kristensen, Thomas S; Thomsen, Anna F

    2017-01-01

    We assessed the CT attenuation density of the pulmonary tissue adjacent to the heart in patients with acute non-ST segment elevation myocardial infarction (J.T. Kuhl, T.S. Kristensen, A.F. Thomsen et al., 2016) [1]. This data was related to the level of ground-glass opacification evaluated...... by a radiologist, and data on the interobserver variability of semi-automated assessment of pulmonary attenuation density was provided....

  3. Multidetector computed tomography findings of dense pulmonary emboli in oncologic patients.

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    Villanueva, Alberto; Díaz, Maria Lourdes; Sánchez, Armando; Castañer, Eva; Bastarrika, Gorka; Broncano, Jordi; del Barrio, Loreto Garcia

    2009-01-01

    Pulmonary embolism is a frequent condition for which multidetector computed tomography (MDCT) plays an important role in its detection. Occasionally, on MDCT studies, dense linear branching opacities may be found within the pulmonary vessels. They represent dense emboli within the pulmonary arteries (DEPA). These may occur in oncologic patients that undergo specific treatments or interventional procedures, such as cement embolus from vertebroplasty, catheter or coil migration after embolization procedures, radioactive seed embolus in patients treated with local brachytherapy for prostate, lung, or liver cancer, and also in chronic pulmonary embolism. Usually DEPA does not have any clinical significance but may be fatal when massive or when in patients with impaired cardiopulmonary function. Being familiar with their radiologic appearance and knowing about the good clinical outcome of these patients will avoid unnecessary imaging testing. In this article, we describe some examples of DEPA. Based on the MDCT imaging findings, these emboli have very few or no side effects on the underlying lung parenchyma. We would like to stress the need for using bone window values for identifying these emboli. We provide examples of dense linear nonvascular images (pulmonary calcification secondary to tuberculosis (TBC) or radiotherapy, calcified mucous plugs, lung sutures, etc) that may mimic DEPA.

  4. Densely calcified tuberculous constrictive pericarditis with concurrent active pulmonary tuberculosis infection

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    S Laudari

    2015-07-01

    Full Text Available Though pulmonary tuberculosis is a common chronic infection in the developing countries like Nepal, the incidence of tubercular constrictive pericarditis is very low. Here we report a patient of active pulmonary tuberculosis with sputum positive for acid fast bacilli along with densely calcified constrictive pericarditis which has been reported as a very rare presentation in the literature.DOI: http://dx.doi.org/10.3126/jcmsn.v10i2.12955 Journal of College of Medical Sciences-Nepal, 2014, Vol.10(2; 41-43

  5. Prevention of posterior capsular opacification

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    Nibourg, Lisanne M; Gelens, Edith; Kuijer, Roelof; Hooymans, Johanna Mm; van Kooten, Theo G; Koopmans, Steven A

    2015-01-01

    Posterior capsular opacification (PCO) is a common complication of cataract surgery. The development of PCO is due to a combination of the processes of proliferation, migration, and transdifferentiation of residual lens epithelial cells (LECs) on the lens capsule. In the past decades, various forms

  6. Incidental mastoid opacification in children on MRI

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    Singh, Sumit; Kuruva, Manohar [University of Arkansas for Medical Sciences, Pediatric Radiology, Little Rock, AR (United States); Rettiganti, Mallikarjuna Rao [University of Arkansas for Medical Sciences and Arkansas Children' s Hospital Research Institute, Biostatistics Program, Department of Pediatrics, Little Rock, AR (United States); Qin, Curtis [Georgetown University Hospital, Radiology, Washington, DC (United States); Hegde, Shilpa V. [University of Pittsburgh Medical Centre, Section of Neuroradiology, Pittsburgh, PA (United States)

    2016-05-15

    The opacification the mastoid cavity is frequently reported by radiologists on cross-sectional imaging done for non-otological indications. It is well known that presence of fluid the mastoid does not amount to mastoiditis. This study seeks to provide an evidence-based confirmation of this known finding. The purpose of our study was to determine the prevalence of mastoid opacification in children undergoing outpatient brain MRI examination. Our study included 515 outpatient children who had brain MRI for indications other than mastoiditis or otitis media from January 2014 to March 2014. Children with history of skull base trauma or radiation were excluded. The age range was 15 days to 18 years. The overall prevalence of mastoid opacification was determined using one sample proportion and exact 95% Clopper-Pearson confidence intervals. The prevalence of mastoid opacification was analyzed based on gender, age and presenting symptoms using chi-square test of association. One hundred ten children (21.4%) had mastoid opacification. Younger patients tended to have higher opacification rates with the prevalence in children younger than 1 year of age and between 1 and 2 years of age as high as 41.7% (20/48) and 47.5% (38/80), respectively. The diagnosis of mastoiditis in children should not be based upon a radiologist's report of finding fluid or mucosal thickening in the mastoid air cells as incidental opacification the mastoid is seen frequently. (orig.)

  7. Influence of aqueous humor convection current on IOL opacification.

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    Agresta, A; Giudiceandrea, A; Salgarello, T; Manganelli, C; Fasciani, R; Caporossi, A

    2016-12-10

    The opacification of Akreos Adapt (Bausch & Lomb, Rochester; NY) intraocular lens (IOL) has been previously reported in Literature. A metabolic change in aqueous humour was considered as the main trigger factor to IOL opacification. We report our case and discuss the association with Ex-PRESS, highlighting the particular pattern of IOL opacification and its possible relation with the intraocular convective motions of the aqueous. We analyzed our case using both digital slit lamp acquisition and OCT Visante (Zeiss, Germany) images. A literature review was conducted to evaluate our results with that previously reported. The role of a relative stationary flow was reported as suggested concurrent mechanism in IOL opacification phenomenon.

  8. Analysis of elements of interlenticular opacification.

    Science.gov (United States)

    Werner, Liliana; Apple, David J; Pandey, Suresh K; Solomon, Kerry D; Snyder, Michael E; Brint, Stephen F; Gayton, Johnny L; Shugar, Joel K; Trivedi, Rupal H; Izak, Andrea M

    2002-03-01

    To report the histopathologic and ultrastructural features of three cases of interlenticular opacification (ILO) between piggyback intraocular lenses. Interventional case series with clinicopathologic correlation. Three pairs of acrylic piggyback lenses were explanted due to decrease in visual acuity associated with ILO. Lenses were evaluated with gross and light microscopic examinations in all cases. The anterior lens in one case was examined with scanning electron microscopy and energy dispersive x-ray spectroscopy. The material opacifying the interlenticular space was composed mostly of retained/regenerative cortical material in all cases. From the peripheral interface towards the central interface, the opacifying material changed as the interlenticular space was progressively narrower. The material attached to the peripheral interface, where the interlenticular space was wider, was very thick. At the midperipheral interface, the thick cortical material was broken into multiple globules due to liquefactive degeneration. At the paracentral zone, compression of the globules formed a flat, compact layer of an amorphous material. At the central interface (contact zone), almost no material could be found between the piggyback lenses. Analyses of ILO cases where all the components of the opacifying material were in situ allowed us to confirm that the pathogenesis of this complication is similar to that of posterior capsule opacification; thus, careful removal of lens epithelial cells and cortical material is mandatory in piggyback implantation.

  9. Akreos Adapt AO Intraocular Lens Opacification: A Case Report

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    Matteo Forlini

    2013-09-01

    Full Text Available A 79-year-old hyperglycemic patient was referred to the ‘Santa Maria delle Croci' Hospital, Ravenna, Italy. He presented with visual impairment in the right eye. Four years ago, he had had an uneventful cataract surgery in the right eye. We observed an opacification of the intraocular lens (IOL causing significant visual disturbance. The IOL was exchanged. Unfortunately, pathologic analysis was not performed. Patient-related factors such as hyperglycemia and hypertension might have been responsible for the opacification. To our knowledge, there is only one previous report of opacification of the Akreos Adapt AO IOL.

  10. Late opacification of a hydrophilic acrylic intraocular lens

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    Al-Bdour Muawyah

    2008-01-01

    Full Text Available Cataract extraction and intraocular lens implantation is considered to be a safe procedure in most cases. However, the new advances in the surgical technique namely phacoemulsification and hence the increased use of foldable intraocular lenses have given rise to new complications including late opacification of intraocular lenses. In this case we report late opacification of a foldable hydrophilic acrylic intraocular lens and the surgical technique for its exchange.

  11. Posterior capsule opacification. Part 1: Experimental investigations.

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    Nishi, O

    1999-01-01

    Posterior capsule opacification (PCO) is the most frequent complication associated with decreased vision after cataract surgery. Previous methods of preventing PCO have not proven to be practical, effective, and safe for routine clinical procedure, but some novel concepts and methods have recently been developed. This 2-part review looks at clinical and experimental investigations of PCO, focusing on developments since 1992. Clinical aspects will be presented in a later issue. This paper addresses (1) in vitro models for PCO research; (2) pathophysiology and molecular biology of lens epithelial cells (LECs); (3) prevention of PCO. Of special interest are methods of culturing human LECs obtained by capsulotomy during cataract surgery, including those obtained with an intact capsular bag, to provide an in vitro model for investigating the pathophysiology of LECs; the effect of a sharp bend in the lens capsule that induces contact inhibition of migrating LECs; more specific inhibition of migrating LECs using an immunotoxin, b-FGF-saporin, or EDTA and RGD-peptides.

  12. Capsular bag opacification with a new accommodating intraocular lens.

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    Floyd, Anne M; Werner, Liliana; Liu, Erica; Stallings, Shannon; Ollerton, Andrew; Leishman, Lisa; Bodnar, Zachary; Morris, Caleb; Mamalis, Nick

    2013-09-01

    To evaluate the biocompatibility and capsular bag opacification of an accommodating intraocular lens (IOL) containing large haptic elements that separate the anterior and posterior capsules. John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Experimental study. Bilateral phacoemulsification with IOL implantation was performed in 6 New Zealand rabbits. Each animal received a study (accommodating) IOL and a control (1-piece hydrophobic acrylic) IOL. Eyes were examined at the slitlamp from 1 day through 6 weeks postoperatively. The globes were then enucleated and evaluated grossly. Capsular bag opacification was scored from the posterior aspect (Miyake-Apple view). The eyes were then processed for complete histopathologic evaluation. At 6 weeks, the mean posterior capsule opacification (PCO) clinical score was 0.5 ± 0.3 (SD) in the study group and 3.0 ± 0.9 in the control group (P=.001, 2-tail paired t test). Anterior capsule opacification was practically absent in the study group and mild in the control group. Miyake-Apple posterior view showed a mean central PCO score of 0 ± 0 in the study group and 3.0 ± 1.1 in the control group (P=.001), peripheral PCO score of 0.7 ± 0.4 and 3.5 ± 0.8 (P=.0006), respectively, and Soemmerring ring score of 2.3 ± 0.8 and 7.0 ± 2.8 (P=.01), respectively. Histopathology showed no signs of toxicity in any eye. The study IOL maintained an expanded capsular bag secondary to the large size of the haptic elements, which appears to prevent capsular bag opacification. Copyright © 2013 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  13. Hydrophilic acrylic intraocular lens opacification after descemet stripping automated endothelial keratoplasty

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    Amir Norouzpour

    2016-01-01

    Conclusion: In an eye with UZS and iatrogenic aniridia, IOL opacification may result from direct contact between the IOL surface and exogenous air. Aniridia can be a risk factor for development of IOL opacification after DSAEK. Further studies are required to confirm this hypothesis.

  14. Voltage mapping for delineating inexcitable dense scar in patients undergoing atrial fibrillation ablation: a new end point for enhancing pulmonary vein isolation.

    Science.gov (United States)

    Squara, Fabien; Frankel, David S; Schaller, Robert; Kapa, Suraj; Chik, William W; Callans, David J; Marchlinski, Francis E; Dixit, Sanjay

    2014-11-01

    Characterization of left atrial scar using bipolar voltage (BiV) mapping is not well defined. We have previously shown that the BiV range of 0.2-0.45 mV can identify chronic scar from prior pulmonary vein isolation (PVI). This study sought to determine a BiV range that can identify atrial inexcitable dense scar (IDS) in patients acutely and chronically after PVI. Thirty consecutive patients undergoing first time (n = 15) or redo (n = 15) PVI were included. A left atrial shell was created using electroanatomic mapping, and IDS was defined by inability to capture at an output of 10 mA and a pulse width of 2 ms in sinus rhythm, circumferentially at the edge of PVI-related scar (≤5 mm). At each pacing site, BiV amplitude and atrial capture were recorded. Overall, 837 pacing sites were assessed. BiV predicted IDS (receiver operating characteristic curve area 0.93 for first time PVI and 0.90 for redo PVI). In first time PVI, the best BiV value to predict IDS was 0.45 mV for the left pulmonary vein-left atrial appendage (LAA-LPV) ridge (sensitivity 0.98; specificity 1.0) and 0.2 mV for other localizations (sensitivity 0.91; specificity 0.86). In redo PVI, the best BiV value to predict IDS was 0.2 mV for the LAA-LPV ridge (sensitivity 0.77; specificity 1.0) and 0.15 mV for other localizations (sensitivity 0.81; specificity 0.82). BiV reproducibly identifies acute and chronic IDS using a cutoff value of 0.2 mV (0.45 mV for the LAA-LPV ridge) in patients undergoing first time PVI and 0.15 mV (0.2 mV for the LAA-LPV ridge) in patients undergoing redo PVI. IDS thus identified may be a rigorous tool for validating PVI. Published by Elsevier Inc.

  15. TRANSFORMING GROWTH FACTOR-β AND FIBROBLAST GROWTH FACTOR INDUCE LENS EPITHELIAL EXPLANT METAPLASIA: IMPLICATIONS FOR THE FORMATION OF SUBCAPSULAR OPACIFICATION

    Institute of Scientific and Technical Information of China (English)

    刘颉; 叶俊杰

    1998-01-01

    Objective. This study was to investigate the effects of transforming growth factor-β(TGFβ) and fibroblast growth factor (FGF) in the subcapsular opaeification formation of the lens. Methods. Lens epithelial explants from 10-day-old rats were cultured with TGFβ1 or TGFβ2 in the presence of FGF for 5 days, then were examined by light and electron microscopy, and by immunolocalization of α-smooth muscle(α-sm) actin and type Ⅰ collagen. Resets. In TGFβ/FGF-treated explants,extensive proliferation oeeured, with formation of spindle and star-shaped cells. These cells showed ultrastructure and biochemical features of fibroblast or myofibroblast.Prominent Golgi apparatus and rough endoplaie reticulum were observed in scene cells, Intracellular microfilaments with cytoplasmic dense bodies and membrane associated dense bodies, features of smooth muscle cells, were also observed. Some cells showed reactivity to α-sin actin antibody. TGFβ/FGF-treated explants were strongly stained with type I collagen antibody. Conclusion. In the presence of FGF, TGFβ1 and TGFβ2 induced lens epithelial cell(LEC)proliferation and transformation into fibroblast or myofibroblast like ceils, with producing of abundant collagen matrix in the explants. The changes are similar to the metaplasia that oeeurrs in subeapsular opacification of the lens. The findings suggest that TGFβ and FGF plays a role in the pathogenesis of subcapsular opacification of the lens.

  16. Effect of four different intraocular lenses on posterior capsule opacification

    Institute of Scientific and Technical Information of China (English)

    Rahmi; Duman; Fatih; Karel; Pelin; ?zyol; Can; Ates

    2015-01-01

    AIM: To evaluate the impact of 4 different intraocular lenses(IOLs) on posterior capsule opacification(PCO) by comparing the neodymium: yttrium-aluminum-garnet(Nd:YAG) laser capsulotomy rates.METHODS: This retrospective study included 4970 eyes of 4013 cataract patients who underwent phacoemulsification and IOL implantation between January 2000 and January 2008 by the same surgeon at one clinic. Four different IOLs were assessed. The outcome parameter was the incidence of Nd:YAG laser posterior capsulotomies.· RESULTS: An Nd:YAG laser posterior capsulotomy was performed in 153(3.07%) of the 4970 eyes. The mean follow-up time was 84 mo for all of the IOL groups. The percentage of eyes developing PCO was significantly greater for the acrylic hydrophilic IOLs than for the hydrophobic IOLs, although eyes with acrylic hydrophilic IOLs did not require Nd:YAG laser capsulotomy as soon as eyes with acrylic hydrophobic IOLs. There was no difference between the long-term PCO rates when 1-and 3-piece acrylic hydrophobic IOLs were compared or when IOLs made of the same material but with different haptic angles were compared.· CONCLUSION: In this study, eyes with acrylic hydrophilic IOLs were more likely to develop PCO than those with acrylic hydrophobic IOLs. The lens design(1-piece versus 3-piece and varying haptic angles) did not affect the PCO rate.

  17. Pulmonary Kaposi sarcoma in six children

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    Theron, Salomine [University of Stellenbosch, Department of Radiology, Tygerberg Academic Hospital, Cape Town (South Africa); University of Stellenbosch, Department of Radiology, Tygerberg Hospital, Cape Town (South Africa); Andronikou, Savvas; Plessis, Jaco du; George, Reena; Mapukata, Ayanda; Grobbelaar, Marie; Hayes, Murray [University of Stellenbosch, Department of Radiology, Tygerberg Academic Hospital, Cape Town (South Africa); Goussard, Pierre [University of Stellenbosch, Department of Child Health, Tygerberg Academic Hospital, Cape Town (South Africa); Wieselthaler, Nicky [University of Cape Town, Department of Radiology, Red Cross Children' s Hospital, Cape Town (South Africa); Davidson, Alan [University of Cape Town, Department of Oncology, Red Cross Children' s Hospital, Cape Town (South Africa)

    2007-12-15

    Pulmonary involvement in Kaposi sarcoma is rare in children and can be difficult to distinguish from other pathology. To describe the radiological findings in paediatric pulmonary Kaposi sarcoma. Sequential chest radiographs of six children and CT scans of four of these children were evaluated retrospectively. Their ages ranged from 18 months to 10 years; four were male and two were female. All six children were HIV-positive. The observers were two radiologists. Chest radiographs revealed air-space (100%) and reticular (83%) opacification in the mid- and lower lung zones; pleural effusions were present in 83% of the children. All the children showed progressive air-space opacification on follow-up radiography. CT demonstrated bilateral air-space opacification in a perihilar distribution in all the children; reticular opacification was seen in 75%. All the children had mediastinal and axillary lymphadenopathy; 75% had bilateral hilar lymphadenopathy. In both adults and children, chest radiography demonstrates perihilar and lower zone involvement. Pleural effusions are more common on radiographs in children. Air-space disease and lymphadenopathy are much more common on CT in children than adults. (orig.)

  18. Dense Breasts

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    ... also appear white on mammography, they can be hidden by or within dense breast tissue. Other imaging ... understanding of the possible charges you will incur. Web page review process: This Web page is reviewed ...

  19. Optical aberrations in pseudophakic eyes after 2.5-mm Nd:YAG laser capsulotomy for posterior capsule opacification.

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    Casprini, Fabrizio; Balestrazzi, Angelo; Tosi, Gian Marco; Lazzarotto, Marco; Malandrini, Alex; Lepri, Francesca; Martone, Gianluca; Caporossi, Tomaso; Caporossi, Aldo

    2008-09-01

    To evaluate aberrometric outcomes in eyes with posterior capsule opacification after 2.5-mm Nd: YAG laser capsulotomy compared to pseudophakic eyes without posterior capsule opacification. Photographic image analysis of posterior capsule opacification was performed on 36 eyes that showed advanced posterior capsule opacification (case group) and on 36 eyes which showed absence of posterior capsule opacification (control group). Best spectacle-corrected visual acuity (BSCVA) and wavefront analysis were performed in the control group and in the case group after 2.5-mm capsulotomy. Mean BSCVA in the case group after treatment was significantly higher than before treatment (P .1). Aberrometric analysis was performed on the control group, but light scattering prevented the analysis in posterior capsule opacification before capsulotomy, which was then performed after the intervention in 18 (50%) eyes. Mean total high order aberrations and 3rd order aberrations were significantly higher in the case group than in the control group (P .06). Our wavefront results can detect a deterioration of visual quality in patients that underwent a 2.5-mm Nd:YAG capsulotomy compared to pseudophakic patients not affected by posterior capsule opacification. This difference cannot be detected by standard visual acuity examination. Further study is needed to clarify whether our high order aberration findings were related to small, 2.5-mm capsulotomies and whether aberrometry may be indicative for mild to moderate posterior capsule opacification.

  20. Neodymium:YAG treatment of interlenticular opacification in a secondary piggyback case.

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    Gayton, J L; Van der Karr, M; Sanders, V

    2001-09-01

    Interlenticular opacification (ILO) developed 7 months after secondary acrylic piggyback lens implantation in which the anterior lens was placed in the bag. This resulted in glare and a hyperopic shift. Treating the ILO with the neodymium:YAG laser successfully reduced the glare and corrected the hyperopic shift.

  1. Prevention of capsular opacification after accommodative lens refilling surgery in rabbits

    NARCIS (Netherlands)

    Koopmans, Steven A.; Terwee, Thom; van Kooten, Theo G.

    2011-01-01

    Silicone gel-like polymers have been proposed to replace the cataractous lens and therewith restore both vision and accommodation. Lens replacement is associated with opacification of the capsular bag due to the lens epithelial cell response. In this study, the in vivo effectiveness of a 5 min treat

  2. Hydrophilic Acrylic Intraocular Lens Opacification after Descemet Stripping Automated Endothelial Keratoplasty

    Science.gov (United States)

    Norouzpour, Amir; Zarei-Ghanavati, Siamak

    2016-01-01

    Purpose: To report hydrophilic acylic intraocular lens (IOL) opacification after Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) in an eye with multiple prior intraocular surgeries and iatrogenic aniridia. Case Report: A 34-year-old woman with history of penetrating keratoplasty (PKP) for advanced keratoconus and subsequent Urrets-Zavalia Syndrome (UZS) underwent phacoemulsification and hydrophilic acrylic IOL implantation for her cataract. In order to control post-PKP glaucoma, multiple glaucoma surgeries including two glaucoma drainage implants were performed. As the original corneal graft failed, the patient subsequently underwent re-PKP. Four years later, she underwent DSAEK for treatment of the second graft failure. Ten months after DSAEK, a double semi-circular pattern of IOL opacification was observed on the anterior surface of the IOL. The patient did not report any complaints and we decided not to exchange the IOL. Conclusion: In an eye with UZS and iatrogenic aniridia, IOL opacification may result from direct contact between the IOL surface and exogenous air. Aniridia can be a risk factor for development of IOL opacification after DSAEK. Further studies are required to confirm this hypothesis. PMID:27413506

  3. Prevention of capsular bag opacification with a modified hydrophilic acrylic disk-shaped intraocular lens.

    Science.gov (United States)

    Leishman, Lisa; Werner, Liliana; Bodnar, Zachary; Ollerton, Andrew; Michelson, Jennifer; Schmutz, Mason; Mamalis, Nick

    2012-09-01

    To evaluate the stability and capsular bag opacification with a modified disk-shaped 1-piece hydrophilic acrylic intraocular lens (IOL) suspended between 2 complete haptic rings connected by a pillar of the haptic material and with a commercially available 1-piece hydrophilic acrylic IOL. John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Experimental study. Study and control IOLs were implanted into the left eyes and right eyes of 5 New Zealand rabbits. Eyes were examined at the slitlamp from 1 through 4 weeks. At 4 weeks, the globes were enucleated and evaluated under a very-high-frequency ultrasound. Photographs were taken and capsular bag opacification scored from the posterior aspect (Miyake-Apple view), and the eyes were processed for complete histopathology. At 4 weeks, the posterior capsule opacification score was 0.0 in the study group and 1.75 ± 0.5 (SD) in the control group (P=.005, paired t test). Ultrasound examination showed that 2 of the study IOLs had no contact between the posterior optic surface and the posterior capsule. Minimal proliferative cortical material was confined to the peripheral space between anterior and posterior rings of the study IOL haptics in localized areas at the equatorial region of the capsular bag. Anterior capsule opacification was absent in all eyes. The study IOL is a modification of a previous design, incorporating haptic perforations between the peripheral rings. By maintaining an open capsular bag and enhancing endocapsular inflow of aqueous, this modified design appears to prevent capsular bag opacification. Copyright © 2012 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  4. Interlenticular opacification: clinicopathological correlation of a complication of posterior chamber piggyback intraocular lenses.

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    Gayton, J L; Apple, D J; Peng, Q; Visessook, N; Sanders, V; Werner, L; Pandey, S K; Escobar-Gomez, M; Hoddinott, D S; Van Der Karr, M

    2000-03-01

    To present a clinicopathological correlation of 2 pairs of piggyback posterior chamber intraocular lenses (PC IOLs) explanted because of opacification between the lens optics. Gayton Health Center, Eyesight Associates of Middle Georgia, Warner Robins, Georgia, and Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA. Two pairs of piggyback AcrySof lenses were explanted from 2 patients with significant visual loss related to opacification between the optics. They were submitted for pathological analysis. Gross and histopathological examinations were performed, and photomicroscopy was used to document the results. Gross examination showed accumulation of a membrane-like white material between the lenses. Histopathological examination revealed that the tissue consisted of retained/proliferative lens epithelial cells (bladder cells or pearls) mixed with lens cortical material. Piggyback PC IOLs were explanted in 2 cases because of a newly described complication, interlenticular opacification. Three surgical means may help prevent this complication: meticulous cortical cleanup, especially in the equatorial region; creation of a relatively large continuous curvilinear capsulorhexis to sequester retained cells peripheral to the IOL optic within the equatorial fornix; insertion of the posterior IOL in the capsular bag and the anterior IOL in the ciliary sulcus to isolate retained cells from the interlenticular space.

  5. [Left pulmonary agenesis diagnosed late].

    Science.gov (United States)

    Deleanu, Oana; Pătraşcu, Natalia; Nebunoiu, Ana-Maria; Vintilă, V; Ulmeanu, Ruxandra; Mihălţan, F D

    2010-01-01

    We present the case of a 51 years old female-patient, with severe dextroscoliosis, having like unique symptom progressive dyspnea. The blood samples reveals polycythemia, the radiological exam shows the opacification of 2/3 of the left thorax, the absence of the lung structure in the other 1/3, the deviation of the mediastinum, and dextroscoliosis; the computed tomography reveals the absence of the left lung artery and the left airways, compensatory hyperinflation of the right lung and dilatation of the trunk and right pulmonary artery; the bronchoscopy does not visualize the carina or the left main bronchus, typical for pulmonary agenesis. Echocardiography confirmed the absence of left pulmonary artery and shows mild pulmonary hypertension (systolic pressure in the pulmonary artery of 33 mmHg) with dilatation of the right cavities, but good cinetics. We face a case of pulmonary agenesis lately diagnosed, with modest functional cardiologic implications, limited therapeutic options and good survival, justified by the late appearance of the pulmonary hypertension of low severity and without worsening in time.

  6. Beware of the devastating pulmonary aspergillosis syndromes In certain environments

    LENUS (Irish Health Repository)

    Kooblall, M

    2016-02-01

    Nowadays with more stem cell transplants and immunosuppressive therapies there has been a rise in pulmonary aspergillosis syndromes. The following illustrates such a case. A 49 year old man had a past history of ankylosing spondylitis with a bilateral hip replacement. He was also on surveillance for a superficial bladder tumour since 2007. His chest x-ray in 2008 was normal. In 2010 his CXR showed patchy opacification in the right apex. CT thorax confirm fibrotic changes.

  7. The effect of palatability of oral contrast media on compliance with drinking protocols, and on bowel opacification, in abdominal CT

    Energy Technology Data Exchange (ETDEWEB)

    Morgan, Bruno [Department of Radiology, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW (United Kingdom)], E-mail: bm11@le.ac.uk; Basu, Avi; Kithoray, Surjinder; Tyagi, Raman; Campbell, Shona; Liddicoat, Amanda [Department of Radiology, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW (United Kingdom)

    2009-05-15

    Purpose: To assess whether palatability of oral contrast in CT has an impact on adherence to oral contrast media drinking protocols; and whether such variation has an impact on bowel opacification. Three different types of contrast media were compared; ionic and non-ionic iodinated oral contrast (Gastrografin, Diatrizoate, Schering AG), Gastromiro (Iopamidol, Bracco SpA) and the barium based contrast E-Z-Cat (E-Z-EM). Materials and methods: In the first stage of the study 101 prospective patients were randomly given 1 L of a {approx}2% solution of Gastrografin or Gastromiro prior to a body CT scan. Data was recorded concerning the palatability of the oral contrast, drinking protocol compliance and bowel opacification. The second stage involved 66 prospective patients given Gastromiro or E-Z-Cat (again 1 L of {approx}2% solution). Results: Gastromiro had better palatability than Gastrografin (p = 0.001) and improved protocol compliance. E-Z-Cat had similar palatability to Gastromiro . Patients who found the oral contrast more palatable had improved drinking protocol compliance (p = 0.007) and improved small bowel opacification (p = 0.03). E-Z-Cat had similar palatability and protocol compliance to Gastromiro but better overall small bowel opacification (p = 0.001). Conclusion: In conclusion we suggest that the palatability of oral contrast is not only important to the patients overall experience of body CT, but that it is also linked to adherence with oral contrast drinking protocols leading to better bowel opacification.

  8. Identification of a novel virulence determinant with serum opacification activity in Streptococcus suis.

    Science.gov (United States)

    Baums, Christoph G; Kaim, Ute; Fulde, Marcus; Ramachandran, Girish; Goethe, Ralph; Valentin-Weigand, Peter

    2006-11-01

    Streptococcus suis serotype 2 is a porcine and human pathogen with adhesive and invasive properties. In other streptococci, large surface-associated proteins (>100 kDa) of the MSCRAMM family (microbial surface components recognizing adhesive matrix molecules) are key players in interactions with host tissue. In this study, we identified a novel opacity factor of S. suis (OFS) with structural homology to members of the MSCRAMM family. The N-terminal region of OFS is homologous to the respective regions of fibronectin-binding protein A (FnBA) of Streptococcus dysgalactiae and the serum opacity factor (SOF) of Streptococcus pyogenes. Similar to these two proteins, the N-terminal domain of OFS opacified horse serum. Serum opacification activity was detectable in sodium dodecyl sulfate extracts of wild-type S. suis but not in extracts of isogenic ofs knockout mutants. Heterologous expression of OFS in Lactococcus lactis demonstrated that a high level of expression of OFS is sufficient to provide surface-associated serum opacification activity. Furthermore, serum opacification could be inhibited by an antiserum against recombinant OFS. The C-terminal repetitive sequence elements of OFS differed significantly from the respective repeat regions of FnBA and SOF as well as from the consensus sequence of the fibronectin-binding repeats of MSCRAMMs. Accordingly, fibronectin binding was not detectable in recombinant OFS. To investigate the putative function of OFS in the pathogenesis of invasive S. suis diseases, piglets were experimentally infected with an isogenic mutant strain in which the ofs gene had been knocked out by an in-frame deletion. The mutant was severely attenuated in virulence but not in colonization, demonstrating that OFS represents a novel virulence determinant of S. suis.

  9. CT urography: a comparison of strategies for upper urinary tract opacification

    Energy Technology Data Exchange (ETDEWEB)

    Sanyal, Rupan; Deshmukh, Amol; Singh Sheorain, Virender; Taori, Kishor [Government Medical College, Department of Radiology, Nagpur (India)

    2007-05-15

    A consensus is yet to be reached regarding the best strategy for ensuring maximum ureteric delineation during CT urography (CTU). In this study we have compared various CTU protocols to try to establish the best method for ureteric delineation. Saline infusion in the supine position, saline infusion in the prone position, furosemide administration (10 mg, iv) and buscopan administration (20 mg iv) with saline infusion in the prone position were tried in four groups, each having 15 patients who were undergoing CTU. The pelvicalyceal system and ureter were divided into six segments, to each of which an opacification score was assigned (0, unopacified segment; 1, less than 50% opacified segment; 2, 50-99% of the segment opacified; or 3, completely opacified segment) and the results compared. Furosemide administration resulted in complete opacification of 93% of the ureters (28 of 30). In the distal (below the sciatic notch) ureter, the mean score with furosemide was 2.9, while that with saline, supine and prone positioning was 1.87 and 1.83, respectively, and this difference was highly significant (P = 0.0002 and P = 0.0001). It was also significantly higher than the buscopan group (score 2.3, P = 0.002). Also in the lower (the iliac crest to the sciatic notch) and upper (above the iliac crest) ureter, furosemide had significantly higher scores than saline infusion in either position. Saline infusion in the supine and prone positions had very similar scores in all segments that were less than the buscopan group, but this difference was not statistically significant. During CT urography, furosemide administration in low doses is the most effective and convenient technique for ureteric opacification. (orig.)

  10. Influence of cardiac hemodynamic parameters on coronary artery opacification with 64-slice computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Husmann, Lars; Alkadhi, Hatem; Boehm, Thomas; Leschka, Sebastian; Desbiolles, Lotus; Marincek, Borut [University Hospital of Zurich, Department of Medical Radiology, Institute of Diagnostic Radiology, Zurich (Switzerland); Schepis, Tiziano; Koepfli, Pascal; Wildermuth, Simon [University Hospital of Zurich, Cardiovascular Center, Zurich (Switzerland); Kaufmann, Philipp A. [University Hospital of Zurich, Cardiovascular Center, Zurich (Switzerland); University of Zurich, Center for Integrative Human Physiology, Zurich (Switzerland)

    2006-05-15

    The purpose of this study was to evaluate the influence of ejection fraction (EF), stroke volume (SV), heart rate, and cardiac output (CO) on coronary artery opacification with 64-slice computed tomography (CT). Sixty patients underwent, retrospectively, electrocardiography-gated 64-slice CT coronary angiography. Left ventricular EF, SV, and CO were calculated with semi-automated software. Attenuation values were measured and contrast-to-noise ratios (CNRs) were calculated in the proximal right coronary artery (RCA) and left main artery (LMA). Mean EF during scanning was 61.5{+-}12.4%, SV was 63.2{+-}15.6 ml, heart rate was 62.5{+-}11.8 beats per minute (bpm), and CO was 3.88{+-}1.06 l/min. There was no significant correlation between the EF and heart rate and the attenuation and CNR in either coronary artery. A significant negative correlation was found in both arteries between SV and attenuation (RCA r=-0.26, P<0.05; LMA r=-0.34, P<0.01) and between SV and CNR (RCA r=-0.26, P<0.05; LMA r=-0.26, P<0.05). Similarly, a significant negative correlation was found between the CO and attenuation (RCA r=-0.42, P<0.05; LMA r=-0.56, P<0.001) and between the CO and CNR (RCA r=-0.39, P<0.05; LMA r=-0.44, P<0.001). The actual hemodynamic status of the patient influences the coronary artery opacification with 64-slice CT, in that vessel opacification decreases as SV and CO increase. (orig.)

  11. Posterior capsule opacification and neovascularization treated with intravitreal bevacizumab and Nd:YAG capsulotomy

    Science.gov (United States)

    Sánchez-Castro, Grimelda Yuriana; Hitos-Fájer, Alejandra; Mendoza-Schuster, Erick; Velez-Montoya, Raul; Velasco-Barona, Cecilio Francisco

    2008-01-01

    We reported a 75-year-old diabetic man, who developed opacification and neovascularization of the posterior capsule after extracapsular cataract extraction and posterior chamber intraocular lens implantation. The patient was treated with two injections of 2.5 mg of intravitreal bevacizumab. The treatment produced an important regression of the posterior capsular new vessels, allowing us to perform a successful Nd:YAG capsulotomy, clearing the visual axis and improving the visualization of the posterior pole. Even though, best corrected visual acuity was 20/200 due to diabetic macular edema. PMID:19668770

  12. Medical image of the week: PE with infarct and pulmonary cavitation

    Directory of Open Access Journals (Sweden)

    Knox KS

    2014-12-01

    Full Text Available No abstract available. Article truncated at 150 words. A 49 year old man with a history of COPD presented to the ER with the sudden onset of chest pain at 3:30 AM waking him from sleep. His pain was left sided, felt like broken ribs, and was worse with deep inspiration. He acknowledged some shortness of breath which was worse over baseline for the past couple days without cough or hemoptysis. The patient was tachycardic but comfortable with SpO2 saturation 98% on 2 liters. He had trace edema and pleurisy. Laboratory evaluation was unremarkable except for a WBC count 13,000 X 106 cells/L. Chest x-ray was unremarkable but thoracic CT scan showed pulmonary emboli (PE involving left upper and lower lobar arteries (Figure 1A and 1B, arrows. Anticoagulation was started and the patient experienced increasing shortness of breath, worsening oxygenation and fever to 102ºF. On Day 2, frontal chest radiograph showed extensive left lung opacification most dense in ...

  13. A new endocapsular open ring for prevention of anterior and posterior capsule opacification

    Science.gov (United States)

    Pallikaris, Ioannis G; Stojanovic, Nela R; Ginis, Harilaos S

    2016-01-01

    Purpose The aim of this study is to demonstrate the functionality of a new design of a thick endocapsular open ring for prevention of anterior capsule opacification (ACO) and posterior capsule opacification (PCO). Setting The Institute of Vision and Optics, University of Crete and University Hospital of Heraklion, Crete, Greece. Design Prospective, interventional pilot study. Methods Fifteen patients (17 eyes) underwent cataract surgery with phacoemulsification. During surgery, a thick endocapsular open ring (peripheral capsule reconstructor) was inserted into the capsular bag, prior to intraocular lens (IOL) implantation. Six different models of IOL were implanted. Postoperatively, the degree of ACO and PCO was evaluated and described as none, mild, moderate, or severe. Results The mean follow-up period was 30±8.06 months (range: 12–36 months). At the last follow-up, mild PCO was observed in only three eyes and mild ACO in three patients. The centration of IOLs was good in all but one eye, which had a tilted IOL. Conclusion The results of this pilot study suggest that the implantation of a new design of thick endocapsular open ring is feasible and may contribute to the prevention of PCO and ACO after cataract surgery. PMID:27843291

  14. The Palisades of Vogt in Congenital Corneal Opacification (An American Ophthalmological Society Thesis).

    Science.gov (United States)

    Nischal, Ken K; Lathrop, Kira L

    2016-08-01

    The purposes of this study are first, to determine if the palisades of Vogt (POV) are present or absent in cases of congenital corneal opacification (CCO) by using spectral domain ocular coherence tomography (SD-OCT), and second, in those cases already undergoing penetrating keratoplasty (PKP), to see whether the absence or presence of POV corresponds to re-epithelialization following transplant. This was a retrospective case review of 20 eyes (10 normal, 10 with CCO) evaluated with SD-OCT. The operator was masked to the clinician's assessment of the ocular surface. In those cases where the decision to perform PKP had already been made, the correlation between POV presence or absence and posttransplant graft epithelialization was determined. All cases were imaged without adverse event. Nine eyes showed some evidence of POV and corresponding vasculature. Eight of 10 affected eyes underwent PKP, and subsequently 7 eyes epithelialized and 2 showed some peripheral neovascularization. The one eye that showed no signs of POV was the one that failed to epithelialize. All control subjects had consistent and regular POV. Congenital corneal opacification is rare, and this study shows that at least some POV are present in the majority of cases of CCO. However, the palisades may not be entirely normal compared to age-matched controls. When there was absence of POV in a case of CCO, there was immediate and complete failure of epithelialization.

  15. A new endocapsular open ring for prevention of anterior and posterior capsule opacification

    Directory of Open Access Journals (Sweden)

    Pallikaris IG

    2016-11-01

    Full Text Available Ioannis G Pallikaris, Nela R Stojanovic, Harilaos S Ginis Institute of Vision and Optics, Department of Medicine, University of Crete, Heraklion, Crete, Greece Purpose: The aim of this study is to demonstrate the functionality of a new design of a thick endocapsular open ring for prevention of anterior capsule opacification (ACO and posterior capsule opacification (PCO. Setting: The Institute of Vision and Optics, University of Crete and University Hospital of Heraklion, Crete, Greece. Design: Prospective, interventional pilot study. Methods: Fifteen patients (17 eyes underwent cataract surgery with phacoemulsification. During surgery, a thick endocapsular open ring (peripheral capsule reconstructor was inserted into the capsular bag, prior to intraocular lens (IOL implantation. Six different models of IOL were implanted. Postoperatively, the degree of ACO and PCO was evaluated and described as none, mild, moderate, or severe. Results: The mean follow-up period was 30±8.06 months (range: 12–36 months. At the last follow-up, mild PCO was observed in only three eyes and mild ACO in three patients. The centration of IOLs was good in all but one eye, which had a tilted IOL. Conclusion: The results of this pilot study suggest that the implantation of a new design of thick endocapsular open ring is feasible and may contribute to the prevention of PCO and ACO after cataract surgery. Keywords: intraocular implant, cataract, phacoemulsification, silicone

  16. Posterior capsule opacification and neovascularization treated with intravitreal bevacizumab and Nd:YAG capsulotomy

    Directory of Open Access Journals (Sweden)

    Grimelda Yuriana Sánchez-Castro

    2008-10-01

    Full Text Available Grimelda Yuriana Sánchez-Castro1, Alejandra Hitos-Fájer1, Erick Mendoza-Schuster1, Raul Velez-Montoya2, Cecilio Francisco Velasco-Barona11Asociación para Evitar la Ceguera en México. Hospital “Dr. Luis Sánchez Bulnes”, México, D.F. Ophthalmology Department – Anterior Segment; 2Asociación para Evitar la Ceguera en México. Hospital “Dr. Luis Sánchez Bulnes”, México, D.F. Ophthalmology Department – Retina departmentAbstract: We reported a 75-year-old diabetic man, who developed opacification and neovascularization of the posterior capsule after extracapsular cataract extraction and posterior chamber intraocular lens implantation. The patient was treated with two injections of 2.5 mg of intravitreal bevacizumab. The treatment produced an important regression of the posterior capsular new vessels, allowing us to perform a successful Nd:YAG capsulotomy, clearing the visual axis and improving the visualization of the posterior pole. Even though, best corrected visual acuity was 20/200 due to diabetic macular edema.Keywords: posterior capsule opacification, posterior capsule neovascularization, cataract surgery, postoperative complications, intravitreal bevacizumab

  17. Ophthalmic drug delivery utilizing two-photon absorption: a novel approach to treat posterior capsule opacification

    Science.gov (United States)

    Kim, H.-C.; Träger, J.; Zorn, M.; Haberkorn, N.; Hampp, N.

    2007-07-01

    Intraocular lens (IOL) implantation is the standard technique to treat cataract. Despite recent progress in surgical procedures, posterior capsule opacification is one of the sill remaining postoperative complications of cataract surgery. We present a novel strategy to reduce the incidence of posterior capsule opacification. A drug delivery polymer suitable for manufacturing intraocular lenses has been developed which enables repeated drug release in a non-invasive and controlled manner. The therapeutic molecules are attached through a UV light sensitive linkage to the polymer backbone which is mainly responsible for the optical properties of the intraocular lenses. However, UV light can not trigger the release of drug from the polymer due to the high absorption of the cornea. We developed linkers which enable drug release by two-photon absorption induced cleavage of the linker structure. Since the two-photon absorption requires high photon densities, this does not occur in ambient light conditions in daily life, but is easily triggered by focused laser beams from a pulsed laser. In this proof-of-principle study we have employed a cyclobutane type linker and investigated the properties of the therapeutic system with the approved drugs 5-fluorouracil and chlorambucil. The controlled drug delivery was successfully demonstrated in vitro and additional cell tests confirmed that the device itself shows no cytotoxicity until photochemical activation. This presented concept can provide a powerful method in ophthalmic drug delivery.

  18. Intraocular Lens Opacification following Intracameral Injection of Recombinant Tissue Plasminogen Activator to Treat Inflammatory Membranes after Cataract Surgery

    Directory of Open Access Journals (Sweden)

    Simon S. M. Fung

    2015-01-01

    Full Text Available Purpose. To report 7 cases of intraocular lens (IOL opacification following treatment of postoperative anterior chamber fibrin with recombinant tissue plasminogen activator (rtPA after cataract surgery. Methods. Retrospective case series of 7 eyes in 7 patients who developed IOL opacification after receiving rtPA for anterior chamber inflammatory membrane formation resulting from phacoemulsification cataract surgery. Three explanted IOLs were investigated with light microscopy, histochemical analysis, scanning electron microscopy, and X-ray spectrometry. Results. All patients underwent uncomplicated cataract surgery and posterior chamber hydrophilic IOL implantation. Anterior chamber inflammatory membranes developed between 1 and 4 weeks of surgery and were treated with intracameral rtPA. IOL opacification was noted between 4 weeks and 6 years after rtPA treatment with reduced visual acuity, and IOL exchange was carried out in 3 patients. Light microscopy evaluation revealed diffuse fine granular deposits on the anterior surface/subsurface of IOL optic that stained positive for calcium salts. Scanning electron microscopy (SEM and energy-dispersive X-ray spectrometry (EDS confirmed the presence of calcium and phosphate on the IOL. Conclusions. Intracameral rtPA, though rapidly effective in the treatment of anterior chamber inflammatory membranes following cataract surgery, may be associated with IOL opacification.

  19. Laser-triggered intraocular implant to induce photodynamic therapy for posterior capsule opacification prevention.

    Science.gov (United States)

    Zhang, Zhaoguo; Huang, Wenyong; Lei, Ming; He, Yuanfeng; Yan, Mina; Zhang, Xuefei; Zhao, Chunshun

    2016-02-10

    Posterior capsule opacification (PCO) is one of the main reasons for loss of vision again after cataract surgery. In this study, intraocular lenses were modified with indocyanine green (ICG) and sealed up with PLGA to form long-term intraocular implants (ICG-IOL). When triggered by laser, ICG-IOL would induce photodynamic therapy (PDT). In-vitro cell viability assay and scratch wound healing assay demonstrated that ICG-IOL could effectively inhibit HLEpiC proliferation and migration without causing damage to the cells far away from it. Laser attenuation test indicated that ICG-IOL could be applied in vivo. In-vivo pharmacodynamics and safety study showed that ICG-IOL could significantly prevent the occurrence of PCO and was safe for intraocular normal tissue. All these results suggested that ICG-IOL would be a very promising candidate for PCO prevention.

  20. Light scattering and light transmittance in intraocular lenses explanted because of optic opacification.

    Science.gov (United States)

    Michelson, Jennifer; Werner, Liliana; Ollerton, Andrew; Leishman, Lisa; Bodnar, Zachary

    2012-08-01

    To assess light scattering and light transmittance in intraocular lenses (IOLs) explanted because of optic opacification. John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Experimental study. Poly(methyl methacrylate) (PMMA) IOLs with snowflake degeneration, hydrophilic acrylic IOLs with different calcification patterns, and 1 calcified silicone IOL explanted from an eye with asteroid hyalosis were studied with gross and light microscopy. Light scattering was measured with an EAS-1000 Scheimpflug camera. Light transmittance was measured with a Lambda 35 UV/Vis spectrophotometer (single-beam configuration with RSA-PE-20 integrating sphere). Analyses were performed at room temperature in the hydrated state and compared with controls. The study evaluated 8 PMMA IOLs, 22 hydrophilic acrylic IOLs, and 1 silicone IOL. Light scattering was as follows: 208 to 223 computer-compatible tapes (CCTs) for PMMA IOLs with snowflake degeneration (control = 9 CCTs); 90 to 227 CCTs for calcified hydrophilic acrylic IOLs (controls = 12 to 23 CCTs); 223 CCTs for the calcified silicone IOL (control = 5 CCTs). The mean light transmittance in the visible light spectrum was 81.08% to 97.10% for PMMA IOLs (control = 98.80%); 78.94% to 97.32% for hydrophilic acrylic IOLs (controls = 97.32% to 98.66%); 94.68% for the silicone IOL (control = 97.74%). Intraocular lens opacification led to very high levels of light scattering and a potential for decreased light transmittance, which play a role in the development of symptoms such as glare and halos, decreased contrast sensitivity, and eventually decreased visual acuity. No author has a financial or proprietary interest in any material or method mentioned. Copyright © 2012 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  1. Dense topological spaces and dense continuity

    Science.gov (United States)

    Aldwoah, Khaled A.

    2013-09-01

    There are several attempts to generalize (or "widen") the concept of topological space. This paper uses equivalence relations to generalize the concept of topological space via the concept of equivalence relations. By the generalization, we can introduce from particular topology on a nonempty set X many new topologies, we call anyone of these new topologies a dense topology. In addition, we formulate some simple properties of dense topologies and study suitable generalizations of the concepts of limit points, closeness and continuity, as well as Jackson, Nörlund and Hahn dense topologies.

  2. [The study of cyclosporin A modified intraocular lens preventing posterior capsular opacification in rabbit eyes].

    Science.gov (United States)

    Teng, H; Zhang, H; Tian, F; Gu, H Q; Liu, X; Sun, J

    2016-02-01

    To investigate the safety and efficacy of cyclosporine A sustained release from modified intraocular lens for preventing posterior capsular opacification (PCO) in rabbit eyes. Forty-five New Zealand albino rabbits undergoing phacoemulsification in their right eyes were randomly and equally divided into three groups. Group A had implanted original IOL, group B had implanted PLGA-IOL(IOL coated with polylactide-glycoli acid), and group C had implanted CsA-PLGA-IOL (CsA loaded PLGA-IOL). All the 45 eyes were examined by a slit-lamp microscope. The intraocular pressures were recorded. Anterior chamber flare and aqueous humor cells were graded at different time point after surgery. The concentrations of CsA in the aqueous humor and blood were determined by high performance liquid chromatography. Anterior segment tissue was histologically examined. Wet posterior capsules were weighed. PCO was graded 6 months later. The mean concentrations of CsA in group C at 2 h,1 d,3 d,7 d,14 d,30 d,60 d after operation were (11.47±2.42) mg/L, (10.30±2.15) mg/L, (6.71±1.45) mg/L, (4.81±1.16) mg/L, (6.11±0.84) mg/L, (2.53±0.77) mg/L, (0.86±0.28) mg/L. The concentrations of CsA in blood were undetectable. During the early days after operation, the reactions of the anterior chamber in group A and B were more severe than group C. The initial appearance of PCO in group C was much later than in the other two groups, and the grade of PCO in group C was much lower than the other two groups. The mean weights of wet posterior capsules in group A(312.86±52.91) mg and B(310.64±62.42) mg were much heavier than that of group C(56.93 ± 24.24) mg. Histological observation showed that there was remarkably less accumulation of lens materials on the posterior capsules in group C than in the other two groups. No toxic actions were found in intraocular tissues in group C. Our study suggested that Cyclosporin A modified intraocular lens could effectively and safely prevent the formation and

  3. Experimental study on cyclosporine A drug delivery system in prevention of posterior capsule opacification after intraocular lens implantation in rabbits

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Objective To study the effect of cyclosporine A drug delivery system (CsA-DDS) on the prevention of posterior capsule opacification (PCO) after experimental intraocular lens implantation in rabbit eyes. Methods Twenty healthy New Zealand white rabbits, whose left eyes and right eyes were used respectively as experiment eyes and controls, were subjected to extracapsular lens extraction and artificial lens implantation. During the operation, CsA-DDS with poly (lactideco-glycolide) as carriers or empty DDS was...

  4. Pulmonary edema

    Science.gov (United States)

    ... congestion; Lung water; Pulmonary congestion; Heart failure - pulmonary edema ... Pulmonary edema is often caused by congestive heart failure . When the heart is not able to pump efficiently, blood ...

  5. Dense with Sense

    Science.gov (United States)

    Aletras, Anthony H.; Ingkanisorn, W. Patricia; Mancini, Christine; Arai, Andrew E.

    2005-09-01

    Displacement encoding with stimulated echoes (DENSE) with a low encoding strength phase-cycled meta-DENSE readout and a two fold SENSE acceleration ( R = 2) is described. This combination reduces total breath-hold times for increased patient comfort during cardiac regional myocardial contractility studies. Images from phantoms, normal volunteers, and a patient are provided to demonstrate the SENSE-DENSE combination of methods. The overall breath-hold time is halved while preserving strain map quality.

  6. Atoms in dense plasmas

    Energy Technology Data Exchange (ETDEWEB)

    More, R.M.

    1986-01-01

    Recent experiments with high-power pulsed lasers have strongly encouraged the development of improved theoretical understanding of highly charged ions in a dense plasma environment. This work examines the theory of dense plasmas with emphasis on general rules which govern matter at extreme high temperature and density. 106 refs., 23 figs.

  7. Quantum dense key distribution

    CERN Document Server

    Degiovanni, I P; Castelletto, S; Rastello, M L; Bovino, F A; Colla, A M; Castagnoli, G C

    2004-01-01

    This paper proposes a new protocol for quantum dense key distribution. This protocol embeds the benefits of a quantum dense coding and a quantum key distribution and is able to generate shared secret keys four times more efficiently than BB84 one. We hereinafter prove the security of this scheme against individual eavesdropping attacks, and we present preliminary experimental results, showing its feasibility.

  8. Factors in the technical quality of gadolinium enhanced magnetic resonance angiography for pulmonary embolism in PIOPED III.

    Science.gov (United States)

    Sostman, H Dirk; Jablonski, Kathleen A; Woodard, Pamela K; Stein, Paul D; Naidich, David P; Chenevert, Thomas L; Weg, John G; Hales, Charles A; Hull, Russell D; Goodman, Lawrence R; Tapson, Victor F

    2012-02-01

    In a multi-center trial, gadolinium enhanced magnetic resonance angiography (MRA) for diagnosis of acute pulmonary embolism (PE) had a high rate of technically inadequate images. Accordingly, we evaluated the reasons for poor quality MRA of the pulmonary arteries in these patients. We performed a retrospective analysis of the data collected in the PIOPED III study. We assessed the relationship to the proportion of examinations deemed "uninterpretable" by central readers to the clinical centers, MR equipment platform and vendors, degree of vascular opacification in different orders of pulmonary arteries; type, frequency and severity of image artifacts; patient co-morbidities, symptoms and signs; and reader characteristics. Centers, MR equipment vendor and platform, degree of vascular opacification, and motion artifacts influenced the likelihood of central reader determinations that images were "uninterpretable". Neither the reader nor patient characteristics (age, body mass index, respiratory rate, heart rate) correlated with the likelihood of determining examinations "uninterpretable". Vascular opacification and motion artifact are the principal factors influencing MRA interpretability. Some centers obtain better images more consistently, but the reasons for differences between centers are unclear.

  9. Three distinct stages of lens opacification in transgenic mice expressing the HIV-1 protease.

    Science.gov (United States)

    Tumminia, S J; Clark, J I; Richiert, D M; Mitton, K P; Duglas-Tabor, Y; Kowalak, J A; Garland, D L; Russell, P

    2001-02-01

    Scanning electron microscopy of the lenses from transgenic mice (TG(72)) containing the HIV-1 protease linked to the lens alphaA-crystallin promoter showed structural changes around postnatal day 16. Frank opacification of the lens was observed at day 24. To relate the biochemical and biophysical changes that occur during the process of cataract development, high-resolution two-dimensional gel electrophoresis (2D), quantitative image analysis and ion measurements were carried out on lenses from postnatal day 10 and on days 15-24. The phase separation temperature (Tc), a measure of molecular interactions between proteins, was also determined for normal and transgenic lenses. A comparison of the transgenic and normal lenses on day 10 revealed no significant differences in any of the measured parameters. However, starting around day 16 or the first stage of observed structural changes, the TG(72)crystallin profiles of the alphaA- alphaB-, betaA3-, betaA4-, betaB3 and one gamma-crystallin began to deviate from the normal. By postnatal day 20, a second stage was initiated with an influx of calcium and sodium ions that was accompanied by modifications of betaB1- and betaB2-crystallin. In the third and final stage of the cataract process, a large increase in the proteolysis of crystallins was accompanied by the appearance of the frank cataract on day 24. The Tc initially increased in all of the mouse lenses until just prior to eyelid opening. After that time, the Tc decreased in all lenses. Although the Tc continued to decrease in the normal lenses with age, for the homozygous transgenic mice it exhibited a dramatic increase that began on day 20. Thus, in the TG(72)transgenic mouse, cataract formation occurs in a three-stage process. Tc and other biophysical parameters previously measured appeared to be insensitive to the modifications that occur during stage 1. However, during the second stage of cataract formation, there was a correspondence between abnormal Tc and the

  10. Features of YAG-laser treatment of posterior capsule opacification in eyes with intraocular comorbidities ext

    Directory of Open Access Journals (Sweden)

    O. I. Borzunov

    2015-01-01

    Full Text Available Purpose: is to evaluate the effectiveness of YAG laser posterior lens capsule dissection in patients with secondary cataract with concurrent intraocular pathology. Patients and methods: retro- and prospective analysis of the results of the YAG — laser treatment of secondary cataract in the 196 eyes, including the intraocular concomitant pathology (myopia, glaucoma, age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa operated retinal detachment, chronic uveitis in remission, peripheral chorioretinal degeneration. Effectiveness of treatment was evaluated by checking visual acuity and dynamics of complaints as aberration, glare, distortion in the central field of view without proper disease of the macula. Complex preoperative studies included: refractometry, visometry with correction, perimetry, tonometry, biomicroscopy, ophthalmoscopy, ultrasound examination of the eyeball (if necessary. The examination results should demonstrate convincing evidence that posterior capsular opacification is the main reason for the decrease of visual acuity. Results:, Visual acuity, at average increased from 0.4‑0.6 to 0.8‑1.0 in 50 cases after dissection, Visual acuity improved to 2‑3 lines in 66‑4–5, 24‑6‑7 lines in 74 cases. Visual acuity remains the same, but contrast sensitivity was increased in 6 cases. The IOL location after disruption was evaluated by β-scanning and biomicroscopy. In case of the initial correct IOL position in all 195 (100 % cases, there were no dislocation in the postoperative period. Complications that can be identified were single microcraters on the IOL surface in cases of its full contact with the posterior capsule. These injuries did not affect the visual functions.Conclusion: YAG -Laser dissection of secondary cataract is effective, less traumatic, and the optimal treatment of secondary cataract, including patients with concomitant intraocular pathology, and helps to avoid over

  11. Pulmonary embolus

    Science.gov (United States)

    ... Blood clot - lung; Embolus; Tumor embolus; Embolism - pulmonary; DVT-pulmonary embolism; Thrombosis - pulmonary embolism ... area). This type of clot is called a deep vein thrombosis (DVT) . The blood clot breaks off and travels ...

  12. Modelling dense relational data

    DEFF Research Database (Denmark)

    Herlau, Tue; Mørup, Morten; Schmidt, Mikkel Nørgaard;

    2012-01-01

    Relational modelling classically consider sparse and discrete data. Measures of influence computed pairwise between temporal sources naturally give rise to dense continuous-valued matrices, for instance p-values from Granger causality. Due to asymmetry or lack of positive definiteness they are no......Relational modelling classically consider sparse and discrete data. Measures of influence computed pairwise between temporal sources naturally give rise to dense continuous-valued matrices, for instance p-values from Granger causality. Due to asymmetry or lack of positive definiteness...... they are not naturally suited for kernel K-means. We propose a generative Bayesian model for dense matrices which generalize kernel K-means to consider off-diagonal interactions in matrices of interactions, and demonstrate its ability to detect structure on both artificial data and two real data sets....

  13. Disease activity in idiopathic pulmonary fibrosis: CT and pathologic correlation.

    Science.gov (United States)

    Müller, N L; Staples, C A; Miller, R R; Vedal, S; Thurlbeck, W M; Ostrow, D N

    1987-12-01

    Computed tomography (CT) scans were compared with pathologic determinants of disease activity in 12 patients with idiopathic pulmonary fibrosis. The theory was that intraalveolar and interstitial cellularity would result in areas of opacification of air spaces on CT scans. All patients underwent open lung biopsy, and disease activity was assessed with a pathologic grading system. Seven patients had mild disease activity, five had moderate to marked disease activity. Opacification of air spaces was patchy in distribution, predominantly peripheral, and seen better on 1.5-mm rather than 10-mm collimation scans. Disease activity on CT scans was graded independently from 0 to 3 based on the presence and relative density of the areas of air space consolidation compared with the surrounding parenchyma. The pathologic score was significantly greater in the patients with high CT scores than in those with low CT scores (P = .001). Five patients with marked disease activity and five of seven patients with mild disease activity were correctly identified. CT may be useful in the assessment of disease activity in idiopathic pulmonary fibrosis.

  14. An experimental study on the effects of curcumin on posterior capsule opacification in young rabbit eyes

    Institute of Scientific and Technical Information of China (English)

    WANG Wen-ying; ZHANG Zhu-jun; WANG Jun; WANG Hai-wei

    2011-01-01

    Background Posterior capsule opacification (PCO) compromises vision development in infants after cataract surgery and lead to amblyopia.To observe the effects of curcumin on PCO in infant rabbits,curcumin was injected under the capaule and into the anterior chamber during phacoemulsification.Methods Seventy-five 1-month-old healthy New Zealand white rabbits were randomized into 3 groups,one eye of each rabbit was randomly selected to be operated.The operation involved continuous circular capsulorhexis,followed by hydrodissection with 0.6 ml each of balanced salt solution (BSS,group A),hydroxypropyl-β-dodextrin (HP-β-CD,90μg/ml,group B) or CUR-HP-β-CD (123 μg/ml,group C),respectively.After phacoemulsification,0.4 ml of each drug solution was injected into the anterior chamber via an incision.The extent of corneal edema and the inflammatory response within the anterior chamber were considered as measures PCO and observed postoperatively.All eyes were examined 1 and 2 months postoperative by slit lamp microscopy and photography after pupil dilation.On the third day postoperative,6 rabbits from each group were executed.Paraffin-embedded sections were stained with hematoxylin-eosin (HE) or terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay (TUNEL,indicative of apoptosis).Stained sections were observed under light microscopy.Proliferation of lens epithelial cells (LECs) was observed microscopically on day 3,day 7,month 1 and month 2 after the operation with HE staining.Results The remission of cornea edema occurred earlier in group C than in groups A and B (P <0.05); there were no significant differences between groups A and B.The remission of anterior chamber exudation in group C was earlier than those in groups A and B (P <0.05).No significant difference in the times when PCO occurred,was observed among groups.Compared to groups A and B,the extent of PCO was less severe (P <0.05).Three days after the operation,LECs aggregated

  15. Sulfadiazine modified PDMS as a model material with the potential for the mitigation of posterior capsule opacification (PCO).

    Science.gov (United States)

    Amoozgar, Bahram; Morarescu, Diana; Sheardown, Heather

    2013-11-01

    Cataract surgery, while the most common surgical procedure performed, leads to posterior capsule opacification in approximately 30% of cases. Transforming growth factor beta 2 (TGF-β2) and matrix metalloproteinases (MMPs) have been shown to play important roles in the cellular processes leading to posterior capsule opacification. Delivery of inhibitors to MMPs may have the potential to inhibit the initial cascade of events that lead to PCO. However, delivery of these molecules via tethering has proven difficult. In this work, sulfadiazine was tethered to polydimethylsiloxane (PDMS) via a polyethylene glycol (PEG) spacer as a potential MMPI mimic. Surface characterization using a variety of methods demonstrated successful modification with the antibiotic. The surfaces were examined with lens epithelial cells to determine their effect on these cellular processes, including cell transdifferentiation and production of extracellular matrix components. The presence of TGF-β2 in the cell culture media was found to stimulate the production of ECM components such as collagen, fibronectin, and laminin, as well as alpha smooth muscle actin (α-SMA), and the migration marker Rho by HLE-B3 and FHL124 cells. In all cases, these effects were decreased but not completely eradicated by the presence of sulfadiazine on the PDMS surfaces. While the level of inhibition necessary for inhibition of PCO in vivo is unknown, these results suggest that IOL surface modification with sulfadiazine has the potential to reduce cellular changes associated with PCO. Furthermore, the results demonstrate for the first time that changes consistent with inhibition of fibrosis may be elicited by surfaces modified with sulfadiazine.

  16. Dense Plasma Focus Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Li, Hui [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Li, Shengtai [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jungman, Gerard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hayes-Sterbenz, Anna Catherine [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-31

    The mechanisms for pinch formation in Dense Plasma Focus (DPF) devices, with the generation of high-energy ions beams and subsequent neutron production over a relatively short distance, are not fully understood. Here we report on high-fidelity 2D and 3D numerical magnetohydrodynamic (MHD) simulations using the LA-COMPASS code to study the pinch formation dynamics and its associated instabilities and neutron production.

  17. Optimizing computed tomography pulmonary angiography using right atrium bolus monitoring combined with spontaneous respiration

    Energy Technology Data Exchange (ETDEWEB)

    Min, Wang; Jian, Li; Rui, Zhai [Jining No. 1 People' s Hospital, Department of Computed Tomography, Jining City, ShanDong Province (China); Wen, Li [Jining No. 1 People' s Hospital, Department of Gastroenterology, Jining, ShanDong (China); Dai, Lun-Hou [Shandong Chest Hospital, Department of Radiology, Jinan, ShanDong (China)

    2015-09-15

    CT pulmonary angiography (CTPA) aims to provide pulmonary arterial opacification in the absence of significant pulmonary venous filling. This requires accurate timing of the imaging acquisition to ensure synchronization with the peak pulmonary artery contrast concentration. This study was designed to test the utility of right atrium (RA) monitoring in ensuring optimal timing of CTPA acquisition. Sixty patients referred for CTPA were divided into two groups. Group A (n = 30): CTPA was performed using bolus triggering from the pulmonary trunk, suspended respiration and 70 ml of contrast agent (CA). Group B (n = 30): CTPA image acquisition was triggered using RA monitoring with spontaneous respiration and 40 ml of CA. Image quality was compared. Subjective image quality, average CT values of pulmonary arteries and density difference between artery and vein pairs were significantly higher whereas CT values of pulmonary veins were significantly lower in group B (all P < 0.05). There was no significant difference between the groups in the proportion of subjects where sixth grade pulmonary arteries were opacified (P > 0.05). RA monitoring combined with spontaneous respiration to trigger image acquisition in CTPA produces optimal contrast enhancement in pulmonary arterial structures with minimal venous filling even with reduced doses of CA. (orig.)

  18. Pulmonary hypertension

    Science.gov (United States)

    ... clots in the lung ( pulmonary embolism ) Heart failure Heart valve disease HIV infection Low oxygen levels in the blood for a long time (chronic) Lung disease, such as COPD or pulmonary fibrosis Medicines (for example, certain diet drugs) Obstructive sleep ...

  19. Pulmonary Edema

    Science.gov (United States)

    ... Accessed March 13, 2014. Pinto DS, et al. Pathophysiology of cardiogenic pulmonary edema. http://www.uptodate.com/ ... hvd/. Accessed March 10, 2014. What is pulmonary hypertension? National Heart, Lung, and Blood Institute. http://www. ...

  20. Pulmonary Fibrosis

    Science.gov (United States)

    Pulmonary fibrosis is a condition in which the tissue deep in your lungs becomes scarred over time. This ... blood may not get enough oxygen. Causes of pulmonary fibrosis include environmental pollutants, some medicines, some connective tissue ...

  1. Pulmonary Rehabilitation

    Science.gov (United States)

    ... shortness of breath and increase your ability to exercise. You may have heard that pulmonary rehabilitation is only for people with COPD (chronic obstructive pulmonary disease). We now know that ...

  2. Warm dense crystallography

    Science.gov (United States)

    Valenza, Ryan A.; Seidler, Gerald T.

    2016-03-01

    The intense femtosecond-scale pulses from x-ray free electron lasers (XFELs) are able to create and interrogate interesting states of matter characterized by long-lived nonequilibrium semicore or core electron occupancies or by the heating of dense phases via the relaxation cascade initiated by the photoelectric effect. We address here the latter case of "warm dense matter" (WDM) and investigate the observable consequences of x-ray heating of the electronic degrees of freedom in crystalline systems. We report temperature-dependent density functional theory calculations for the x-ray diffraction from crystalline LiF, graphite, diamond, and Be. We find testable, strong signatures of condensed-phase effects that emphasize the importance of wide-angle scattering to study nonequilibrium states. These results also suggest that the reorganization of the valence electron density at eV-scale temperatures presents a confounding factor to achieving atomic resolution in macromolecular serial femtosecond crystallography (SFX) studies at XFELs, as performed under the "diffract before destroy" paradigm.

  3. Dense Suspension Splash

    Science.gov (United States)

    Zhang, Wendy; Dodge, Kevin M.; Peters, Ivo R.; Ellowitz, Jake; Klein Schaarsberg, Martin H.; Jaeger, Heinrich M.

    2014-03-01

    Upon impact onto a solid surface at several meters-per-second, a dense suspension plug splashes by ejecting liquid-coated particles. We study the mechanism for splash formation using experiments and a numerical model. In the model, the dense suspension is idealized as a collection of cohesionless, rigid grains with finite surface roughness. The grains also experience lubrication drag as they approach, collide inelastically and rebound away from each other. Simulations using this model reproduce the measured momentum distribution of ejected particles. They also provide direct evidence supporting the conclusion from earlier experiments that inelastic collisions, rather than viscous drag, dominate when the suspension contains macroscopic particles immersed in a low-viscosity solvent such as water. Finally, the simulations reveal two distinct routes for splash formation: a particle can be ejected by a single high momentum-change collision. More surprisingly, a succession of small momentum-change collisions can accumulate to eject a particle outwards. Supported by NSF through its MRSEC program (DMR-0820054) and fluid dynamics program (CBET-1336489).

  4. Dense Axion Stars

    CERN Document Server

    Braaten, Eric; Zhang, Hong

    2015-01-01

    If the dark matter consists of axions, gravity can cause them to coalesce into axion stars, which are stable gravitationally bound Bose-Einstein condensates of axions. In the previously known axion stars, gravity and the attractive force between pairs of axions are balanced by the kinetic pressure.If the axion mass energy is $mc^2= 10^{-4}$ eV, these dilute axion stars have a maximum mass of about $10^{-14} M_\\odot$. We point out that there are also dense axion stars in which gravity is balanced by the mean-field pressure of the axion condensate. We study axion stars using the leading term in a systematically improvable approximation to the effective potential of the nonrelativistic effective field theory for axions. Using the Thomas-Fermi approximation in which the kinetic pressure is neglected, we find a sequence of new branches of axion stars in which gravity is balanced by the mean-field interaction energy of the axion condensate. If $mc^2 = 10^{-4}$ eV, the first branch of these dense axion stars has mas...

  5. Dense Axion Stars

    Science.gov (United States)

    Braaten, Eric; Mohapatra, Abhishek; Zhang, Hong

    2016-09-01

    If the dark matter particles are axions, gravity can cause them to coalesce into axion stars, which are stable gravitationally bound systems of axions. In the previously known solutions for axion stars, gravity and the attractive force between pairs of axions are balanced by the kinetic pressure. The mass of these dilute axion stars cannot exceed a critical mass, which is about 10-14M⊙ if the axion mass is 10-4 eV . We study axion stars using a simple approximation to the effective potential of the nonrelativistic effective field theory for axions. We find a new branch of dense axion stars in which gravity is balanced by the mean-field pressure of the axion Bose-Einstein condensate. The mass on this branch ranges from about 10-20M⊙ to about M⊙ . If a dilute axion star with the critical mass accretes additional axions and collapses, it could produce a bosenova, leaving a dense axion star as the remnant.

  6. Dense Axion Stars

    Science.gov (United States)

    Mohapatra, Abhishek; Braaten, Eric; Zhang, Hong

    2016-03-01

    If the dark matter consists of axions, gravity can cause them to coalesce into axion stars, which are stable gravitationally bound Bose-Einstein condensates of axions. In the previously known axion stars, gravity and the attractive force between pairs of axions are balanced by the kinetic pressure. If the axion mass energy is mc2 =10-4 eV, these dilute axion stars have a maximum mass of about 10-14M⊙ . We point out that there are also dense axion stars in which gravity is balanced by the mean-field pressure of the axion condensate. We study axion stars using the leading term in a systematically improvable approximation to the effective potential of the nonrelativistic effective field theory for axions. Using the Thomas-Fermi approximation in which the kinetic pressure is neglected, we find a sequence of new branches of axion stars in which gravity is balanced by the mean-field interaction energy of the axion condensate. If mc2 =10-4 4 eV, the first branch of these dense axion stars has mass ranging from about 10-11M⊙ toabout M⊙.

  7. DENSE MEDIUM CYCLONE OPTIMIZATON

    Energy Technology Data Exchange (ETDEWEB)

    Gerald H. Luttrell; Chris J. Barbee; Peter J. Bethell; Chris J. Wood

    2005-06-30

    Dense medium cyclones (DMCs) are known to be efficient, high-tonnage devices suitable for upgrading particles in the 50 to 0.5 mm size range. This versatile separator, which uses centrifugal forces to enhance the separation of fine particles that cannot be upgraded in static dense medium separators, can be found in most modern coal plants and in a variety of mineral plants treating iron ore, dolomite, diamonds, potash and lead-zinc ores. Due to the high tonnage, a small increase in DMC efficiency can have a large impact on plant profitability. Unfortunately, the knowledge base required to properly design and operate DMCs has been seriously eroded during the past several decades. In an attempt to correct this problem, a set of engineering tools have been developed to allow producers to improve the efficiency of their DMC circuits. These tools include (1) low-cost density tracers that can be used by plant operators to rapidly assess DMC performance, (2) mathematical process models that can be used to predict the influence of changes in operating and design variables on DMC performance, and (3) an expert advisor system that provides plant operators with a user-friendly interface for evaluating, optimizing and trouble-shooting DMC circuits. The field data required to develop these tools was collected by conducting detailed sampling and evaluation programs at several industrial plant sites. These data were used to demonstrate the technical, economic and environmental benefits that can be realized through the application of these engineering tools.

  8. Pulmonary vasculitis.

    Science.gov (United States)

    Lally, Lindsay; Spiera, Robert F

    2015-05-01

    Pulmonary vasculitis encompasses inflammation in the pulmonary vasculature with involved vessels varying in caliber from large elastic arteries to capillaries. Small pulmonary capillaries are the vessels most commonly involved in vasculitis affecting the lung. The antineutrophil cytoplasmic antibody-associated vasculitides, which include granulomatosis with polyangiitis (formerly Wegener granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome), are the small vessel vasculitides in which pulmonary vasculitis is most frequently observed and are the major focus of this review. Vasculitic involvement of the large pulmonary vessels as may occur in Behçet syndrome and Takayasu arteritis is also discussed.

  9. Hyperons in dense matter

    Energy Technology Data Exchange (ETDEWEB)

    Dapo, Haris

    2009-01-28

    The hyperon-nucleon YN low momentum effective interaction (V{sub low} {sub k}) allows for an extensive study of the behavior of hyperons in dense matter, together with an investigation of effects of the presence of hyperons on dense matter. The first step towards this goal is the construction of the matrix elements for the hyperon-nucleon low momentum potential. In order to assess the different properties of hyperons within these potentials we calculate the hyperon single-particle potentials in the Hartree-Fock approximation for all of the interactions. Their dependence on both momentum and density, is studied. The single-particle potentials are then used to determine the chemical potential of hyperons in neutron stars. For nucleonic properties, the nucleon-nucleon V{sub low} {sub k} can be used with the caveat that the calculation of the ground-state energy of symmetric nuclear matter does not correctly reproduce the properties of matter at saturation. With the nucleon-nucleon V{sub low} {sub k} one is unable to reach the densities needed for the calculation of neutron star masses. To circumvent this problem we use two approaches: in the first one, we parametrize the entire nucleonic sector. In the second one, we replace only the three-body force. The former will enable us to study neutron star masses, and the latter for studying the medium's response to the external probe. In this thesis we take the external probe to be the neutrino. By combining this parametrization with the YN V{sub low} {sub k} potential, we calculate the equation of state of equilibrated matter. Performing the calculation in the Hartree-Fock approximation at zero temperature, the concentrations of all particles are calculated. From these we can ascertain at which densities hyperons appear for a wide range of parameters. Finally, we calculate the masses of neutron stars with these concentrations. For the calculation of the medium's response to an external probe, we replace the three

  10. Lens Epithelial Cell Death Secondary to Acanthamoeba Keratitis: Absence of Capsular Bag Opacification Six Years after Cataract Surgery

    Directory of Open Access Journals (Sweden)

    Javier Moreno-Montañés

    2011-12-01

    Full Text Available Purpose: To show the evolution of anterior chamber structures 6 years after cataract surgery in a case with Acanthamoeba keratitis (AK. Methods: A 37-year-old woman with AK receiving long-term treatment with chlorhexidine, propamidine isethionate and steroids developed a white cataract and iris atrophy. Penetrating keratoplasty and cataract surgery were performed with subsequent intraocular pressure elevation requiring Molteno shunt implantation. Two years after the last surgery, endothelial decompensation developed and another penetrating keratoplasty was performed. Intraoperatively, the anterior and posterior capsules were completely transparent. Results: Six years after cataract surgery, the intraocular lens was centered with clear anterior and posterior capsules without lens epithelial cells proliferation. No Soemmering’s ring formation or posterior capsule opacification was found. Also, no zonular damage or pseudophacodonesis was observed. Conclusions: This case suggests that AK infection and AK treatment not only cause white progressive cataract but also lens epithelial cell death. The capsules may be completely clear 6 years after cataract surgery, with a good quality of vision regardless of intraocular lens material or design.

  11. Corrected coronary opacification decrease from coronary computed tomography angiography: Validation with quantitative 13N-ammonia positron emission tomography.

    Science.gov (United States)

    Benz, Dominik C; Gräni, Christoph; Ferro, Paola; Neumeier, Luis; Messerli, Michael; Possner, Mathias; Clerc, Olivier F; Gebhard, Catherine; Gaemperli, Oliver; Pazhenkottil, Aju P; Kaufmann, Philipp A; Buechel, Ronny R

    2017-07-06

    To assess the functional relevance of a coronary artery stenosis, corrected coronary opacification (CCO) decrease derived from coronary computed tomography angiography (CCTA) has been proposed. The present study aims at validating CCO decrease with quantitative 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI). This retrospective study consists of 39 patients who underwent hybrid CCTA/PET-MPI. From CCTA, attenuation in the coronary lumen was measured before and after a stenosis and corrected to the aorta to calculate CCO and its decrease. Relative flow reserve (RFR) was calculated by dividing the stress myocardial blood flow (MBF) of a vessel territory subtended by a stenotic coronary by the stress MBF of the reference territories without stenoses. RFR was abnormal in 11 vessel territories (27%). CCO decrease yielded a sensitivity, specificity, negative predictive value, positive predictive value, and accuracy for prediction of an abnormal RFR of 73%, 70%, 88%, 47%, and 70%, respectively. CCTA-derived CCO decrease has moderate diagnostic accuracy to predict an abnormal RFR in PET-MPI. However, its high negative predictive value to rule out functional relevance of a given lesion may confer clinical implications in the diagnostic work-up of patients with a coronary stenosis.

  12. A Tight Spot After Pulmonary Vein Catheter Ablation

    NARCIS (Netherlands)

    Amir, Rabia; Yeh, Lu; Montealegre-Gallegos, Mario; Saraf, Rabya; Matyal, Robina; Mahmood, Feroze

    2016-01-01

    A 52-YEAR-OLD woman with a history of embolic stroke due to paroxysmal atrial fibrillation was referred to the authors’ institution for epicardial surgical pulmonary vein isolation with left atrial appendage resection. The patient had 2 previous failed pulmonary vein catheter ablations. Dense

  13. A Tight Spot After Pulmonary Vein Catheter Ablation

    NARCIS (Netherlands)

    Amir, Rabia; Yeh, Lu; Montealegre-Gallegos, Mario; Saraf, Rabya; Matyal, Robina; Mahmood, Feroze

    2016-01-01

    A 52-YEAR-OLD woman with a history of embolic stroke due to paroxysmal atrial fibrillation was referred to the authors’ institution for epicardial surgical pulmonary vein isolation with left atrial appendage resection. The patient had 2 previous failed pulmonary vein catheter ablations. Dense fibrou

  14. Functional live cell imaging of the pulmonary neuroepithelial body microenvironment

    NARCIS (Netherlands)

    De Proost, Ian; Pintelon, Isabel; Brouns, Inge; Kroese, A; Riccardi, Daniela; Kemp, Paul J.; Timmermans, Jean-Pierre; Adriaensen, Dirk

    2008-01-01

    Pulmonary neuroepithelial bodies (NEBs) are densely innervated groups of neuroendocrine cells invariably accompanied by Clara-like cells. Together with NEBs, Clara-like cells form the so-called "NEB microenvironment," which recently has been assigned a potential pulmonary stem cell niche. Conclusive

  15. Functional live cell imaging of the pulmonary neuroepithelial body microenvironment

    NARCIS (Netherlands)

    De Proost, Ian; Pintelon, Isabel; Brouns, Inge; Kroese, A; Riccardi, Daniela; Kemp, Paul J.; Timmermans, Jean-Pierre; Adriaensen, Dirk

    Pulmonary neuroepithelial bodies (NEBs) are densely innervated groups of neuroendocrine cells invariably accompanied by Clara-like cells. Together with NEBs, Clara-like cells form the so-called "NEB microenvironment," which recently has been assigned a potential pulmonary stem cell niche. Conclusive

  16. Pulmonary hypertension

    Directory of Open Access Journals (Sweden)

    Lauro Martins Júnior

    2014-12-01

    Full Text Available Pulmonary hypertension is a pathological condition associated with various diseases, which must be remembered by the physicians, since early diagnosis may anticipate and avoid dangerous complications and even death if appropriate measures were not taken. The relationship with chronic obstructive pulmonary disease (COPD, important pathological process that is in increasing prevalence in developing countries, and leading position as cause of death, emphasizes its importance. Here are presented the classifications, pathophysiology, and general rules of treatment of pulmonary hypertension.

  17. Conductive dense hydrogen

    Science.gov (United States)

    Eremets, M.; Troyan, I.

    2012-12-01

    Hydrogen at ambient pressures and low temperatures forms a molecular crystal which is expected to display metallic properties under megabar pressures. This metal is predicted to be superconducting with a very high critical temperature Tc of 200-400 K. The superconductor may potentially be recovered metastably at ambient pressures, and it may acquire a new quantum state as a metallic superfluid and a superconducting superfluid. Recent experiments performed at low temperatures T 220 GPa, new Raman modes arose, providing evidence for the transformation to a new opaque and electrically conductive phase IV. Above 260 GPa, in the next phase V, hydrogen reflected light well. Its resistance was nearly temperature-independent over a wide temperature range, down to 30 K, indicating that the hydrogen was metallic. Releasing the pressure induced the metallic phase to transform directly into molecular hydrogen with significant hysteresis at 200 GPa and 295 K. These data were published in our paper: M. I. Eremets and I. A. Troyan "Conductive dense hydrogen." Nature Materials 10: 927-931. We will present also new results on hydrogen: phase diagram with phases IV and V determined in P,T domain up to 300 GPa and 350 K. We will also discuss possible structures of phase IV based on our Raman and infrared measurements up to 300 GPa.

  18. Dense Hypervelocity Plasma Jets

    Science.gov (United States)

    Case, Andrew; Witherspoon, F. Douglas; Messer, Sarah; Bomgardner, Richard; Phillips, Michael; van Doren, David; Elton, Raymond; Uzun-Kaymak, Ilker

    2007-11-01

    We are developing high velocity dense plasma jets for fusion and HEDP applications. Traditional coaxial plasma accelerators suffer from the blow-by instability which limits the mass accelerated to high velocity. In the current design blow-by is delayed by a combination of electrode shaping and use of a tailored plasma armature created by injection of a high density plasma at a few eV generated by arrays of capillary discharges or sparkgaps. Experimental data will be presented for a complete 32 injector gun system built for driving rotation in the Maryland MCX experiment, including data on penetration of the plasma jet through a magnetic field. We present spectroscopic measurements of plasma velocity, temperature, and density, as well as total momentum measured using a ballistic pendulum. Measurements are in agreement with each other and with time of flight data from photodiodes and a multichannel PMT. Plasma density is above 10^15 cm-3, velocities range up to about 100 km/s. Preliminary results from a quadrature heterodyne HeNe interferometer are consistent with these results.

  19. Heavy mesons in dense matter

    NARCIS (Netherlands)

    Tolos, Laura; Gamermann, Daniel; Garcia-Recio, Carmen; Molina, Raquel; Nieves, Juan; Oset, Eulogio; Ramos, Angels; LlanesEstrada, FJ; Pelaez,

    2011-01-01

    Charmed mesons in dense matter are studied within a unitary coupled-channel approach which takes into account Pauli-blocking effects and meson self-energies in a self-consistent manner. We obtain the open-charm meson spectral functions in this dense medium, and discuss their implications on hidden c

  20. Estimation of cardiac output and pulmonary vascular resistance by contrast echocardiography transit time measurement: a prospective pilot study.

    Science.gov (United States)

    Choi, Brian G; Sanai, Reza; Yang, Benjamin; Young, Heather A; Mazhari, Ramesh; Reiner, Jonathan S; Lewis, Jannet F

    2014-10-31

    Studies with other imaging modalities have demonstrated a relationship between contrast transit and cardiac output (CO) and pulmonary vascular resistance (PVR). We tested the hypothesis that the transit time during contrast echocardiography could accurately estimate both CO and PVR compared to right heart catheterization (RHC). 27 patients scheduled for RHC had 2D-echocardiogram immediately prior to RHC. 3 ml of DEFINITY contrast followed by a 10 ml saline flush was injected, and a multi-cycle echo clip was acquired from the beginning of injection to opacification of the left ventricle. 2D-echo based calculations of CO and PVR along with the DEFINITY-based transit time calculations were subsequently correlated with the RHC-determined CO and PVR. The transit time from full opacification of the right ventricle to full opacification of the left ventricle inversely correlated with CO (r=-0.61, p<0.001). The transit time from peak opacification of the right ventricle to first appearance in the left ventricle moderately correlated with PVR (r=0.46, p<0.01). Previously described echocardiographic methods for the determination of CO (Huntsman method) and PVR (Abbas and Haddad methods) did not correlate with RHC-determined values (p = 0.20 for CO, p = 0.18 and p = 0.22 for PVR, respectively). The contrast transit time method demonstrated reliable intra- (p<0.0001) and inter-observer correlation (p<0.001). We describe a novel method for the quantification of CO and estimation of PVR using contrast echocardiography transit time. This technique adds to the methodologies used for noninvasive hemodynamic assessment, but requires further validation to determine overall applicability.

  1. Medical image of teh week: idiopathic pulmonary hemosiderosis

    Directory of Open Access Journals (Sweden)

    Reyes N

    2014-07-01

    Full Text Available No abstract available. Article truncated at 150 words. The patient is a 40 year-old man who was diagnosed with Idiopathic Pulmonary Hemosiderosis (IPH at the age of three. He has recurrent episodes of hemoptysis several times a year that are controlled with increased doses of prednisone. He is chronically on 10 mg daily which usually control his symptoms. A HRCT scan of the chest shows predominantly upper lung cystic changes both subpleural and clustered with a honeycomb appearance superimposed on a background of diffuse ground glass opacification. Typical HRCT findings include patchy scattered areas of ground glass opacity and consolidation that usually involve the perihilar and lower aspects of the lungs. However, case reports of rare findings of multiple honeycomb cystic changes have been reported that are thought to be a result of progressive fibrotic changes from hemosiderin deposition in the interstitium (1. These honeycomb cysts may represent sites of more severe and recurrent alveolar hemorrhage in adults ...

  2. Atypical Radiological Manifestation of Pulmonary Metastatic Calcification

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Eun Hae; Kim, Eun Sun; Kim, Chul Hwan; Ham, Soo Youn; Oh, Yu Whan [Korea University College of Medicine, Seoul (Korea, Republic of)

    2008-04-15

    Metastatic pulmonary calcification is a condition of calcium deposition in the normal pulmonary parenchyma, and this is secondary to abnormal calcium metabolism without any prior soft tissue damage. The predisposing factors for this condition include chronic renal failure, hypercalcemia and increased tissue alkalinity. The most common radiologic manifestation consists of poorly defined nodular opacities in the upper lung zone. These opacities reflect the deposition of calcium salts in the pulmonary interstitium. We present here a case of metastatic pulmonary calcification in a patient who recovered from pneumonia with sepsis and whose high-resolution CT (HRCT) images demonstrated localized parenchymal airspace calcification that was limited to the bilateral lower lobes. These lower lobes had been involved with pneumonic consolidation without calcification, as seen on the previous CT scan. In summary, we report here on an atypical presentation of metastatic pulmonary calcification that showed dense airspace consolidation localized to the bilateral lower lobes in a patient with primary hyperparathyroidism and pneumonia.

  3. Experimental study on cyclosporine A drug delivery system in prevention of posterior capsule opacification after intraocular lens implantation in rabbits

    Institute of Scientific and Technical Information of China (English)

    Pei Cheng; Sun Naixue

    2008-01-01

    Objective To study the effect of cyclosporine A drug delivery system (CsA-DDS) on the prevention of posterior capsule opacification (PCO) after experimental intraocular lens implantation in rabbit eyes. Methods Twenty healthy New Zealand white rabbits, whose left eyes and right eyes were used respectively as experiment eyes and controls, were subjected to extracapsular lens extraction and artificial lens implantation. During the operation, CsA-DDS with poly (lactideco-glycolide) as carriers or empty DDS was implanted in the capsular bag for the experimental eyes and controls respectively. After the operation, anterior chamber reaction, intraocular pressure (IOP) and CsA concentration were monitored and twelve weeks after the operation, the eyes were extracted for histopathological and morphological examinations. Results There were no differences between the two groups in conjunctival congestion,IOP change and anterior chamber reaction. PCO was less severe in the experimental eyes than in the controls. Light microscopy revealed that posterior capsular membrane in the experimental eyes was slick, with no obvious proliferation,whereas in the controls, there were lens epithelial cell proliferation and cortex regeneration of different degrees.Morphological examination with electron microscope showed that in the experimental eyes, lens epithelial cells did not function actively and apoptosis occurred, whereas in the controls, epithelial cells presented active function. No marked ultrastructural changes were found in either group. Conclusion Cs-DDS can inhibit PCO after intraocular lens implantation in rabbit eyes and does not have toxic effects on the surrounding ocular tissues. Therefore, it has a good potential for clinical use in prevention of PCO.

  4. Densely crosslinked polycarbosiloxanes .1. Synthesis

    NARCIS (Netherlands)

    Flipsen, T.A C; Derks, R.; van der Vegt, H.A.; Pennings, A.J; Hadziioannou, G

    1997-01-01

    Novel densely crosslinked polycarbosiloxanes were obtained by using functional branched prepolymers. Two types of soluble prepolymers were prepared from di- and trifunctional alkoxysilane monomers via cohydrolysis/condensation and for both final crosslinking occurred via hydrosilylation. The prepoly

  5. Pulmonary aspergilloma

    Science.gov (United States)

    ... grows on dead leaves, stored grain, bird droppings, compost piles, and other decaying vegetation. Cavities in the ... Histoplasmosis Lung cancer - small cell Pulmonary tuberculosis Sarcoidosis Review Date 8/31/2014 Updated by: Jatin M. ...

  6. Pulmonary tuberculosis

    Science.gov (United States)

    ... ray Pulmonary nodule, solitary - CT scan Miliary tuberculosis Tuberculosis of the lungs Erythema nodosum associated with sarcoidosis Respiratory system Tuberculin skin test References Fitzgerald DW, Sterling TR, Haas DW. ...

  7. Pulmonary hypertension

    OpenAIRE

    2016-01-01

    In 2015, more than 800 papers were published in the field of pulmonary hypertension. A Clinical Year in Review article cannot possibly incorporate all this work and needs to be selective. The recently published European guidelines for the diagnosis and treatment of pulmonary hypertension contain an inclusive summary of all published clinical studies conducted until very recently. Here, we provide an overview of papers published after the finalisation of the guideline. In addition, we summaris...

  8. Pulmonary Agenesis.

    Science.gov (United States)

    Chawla, Rakesh K; Madan, Arun; Chawla, Aditya; Arora, Harsh Nandini; Chawla, Kiran

    2015-01-01

    Unilateral opaque lung with ipsilateral mediastinal shift is an uncommon cause of respiratory distress in newborn which can be found on simple radiograph of the chest. Pulmonary agenesis is a rare cause of unilateral opaque lung in the newborn. Nearly 50% cases of pulmonary agenesis are associated with other congenital defects including cardiovascular, skeletal, gastrointestinal or genitourinary systems. We report an infant with agenesis of the right lung associated with other congenital anomalies.

  9. Pulmonary Edema

    OpenAIRE

    Tanser, Paul H.

    1981-01-01

    The physician who deals with pulmonary edema from a pathophysiologic basis will seldom make a diagnostic or therapeutic error. Recent additions to preload and afterload therapy have greatly helped in the emergency and ambulatory treatment of pulmonary edema due to left heart failure. Careful follow-up and patient self-monitoring are the most effective means of reducing hospitalization of chronic heart failure patients.

  10. Influence of Intraocular Lens Material and Eye Axial Length on Posterior Capsule Opacification Dynamic Rate and Frequency

    Directory of Open Access Journals (Sweden)

    G. V. Sorokoletov

    2016-01-01

    Full Text Available Purpose: To evaluate posterior capsule opacification (PCO formation dynamic rate and frequency in artificial eyes with myopia in different terms after cataract extraction and it’s relation with IOL material. Patients and methods. An evaluation of PCO formationdynamic rate and frequency was done by using a retrospective analysis of YAG-laser assist posterior capsule dissections in different terms after cataract extraction on 45640 eyes of 43520 patients with emmetropia and myopia without concomitant pathology.The mean patient’s age was 73±7 years and the least follow-up after  hacoemulsification was 5 years. All eyes were divided on two groups. The first group included 25339 eyes where a hydrophilic IOL was implanted; the second group included 20301 eyes where a hydrophobic IOL was implanted. Results. At the first group the YAG-laser assist posterior capsule dissection was done on 2128 (8,4% eyes. It was shown a proportional influence of axial length on PCO frequency but more rapidly the PCO rate increased between 26 to 28 mm and then this parameter had stabilization. The PCO dynamic rate had a normal statistical corresponding in the group with maximum at third postoperative year. At the second group YAG-laser assist posterior capsule dissection was done on 244 (1,2% eyes. It was shown a proportional influence of axial length on PCO frequency too. But increasing of axial length more than 28 mmincreased PCO rate correspondingly that differ the second group from the first. The PCO dynamic rate had an inversely proportional character in the group. Comparing the PCO frequency in both groups showed that hydrophobic material has less PCO rate with any axial length and every time of follow-up. Conclusion. An IOL’s material plays an important role in PCO formation and PCO formation dynamic rate. Hydrophobic material has a statistically significant less PCO frequency through five-year follow-up in eyes with myopia and emmetropia. The PCO dynamic

  11. Clinical analysis of contributors to the delayed gallbladder opacification following the use of water-soluble contrast medium

    Directory of Open Access Journals (Sweden)

    Ku MC

    2016-09-01

    Full Text Available Ming-Chang Ku,1,2 Victor C Kok,3,4 Ming-Yung Lee,5 Soa-Min Hsu,1 Pei-Yu Lee,1 Che-Wei Chang,1 Yeu-Sheng Tyan,6 Chi-Wen Juan7,8 1Department of Radiology, Kuang Tien General Hospital, Taichung, 2Department of Nursing, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, 3Department of Internal Medicine, Division of Medical Oncology, Kuang Tien General Hospital, 4Department of Bioinformatics and Medical Engineering, Asia University, 5Department of Statistics and Informatics Science, Providence University, 6Department of Medical Imaging, Chung Shan Medical University Hospital, 7Department of Emergency Medicine, Kuang Tien General Hospital, 8Department of Nursing, HungKuang University, Taichung, Taiwan Objectives: Gallbladder opacification (GBO on computed tomography (CT imaging may obscure certain pathological or emergent conditions in the gallbladder, such as neoplasms, stones, and hemorrhagic cholecystitis. This study aimed to investigate the clinical contributing factors that could predict the presence of delayed GBO determined by CT.Methods: This study retrospectively evaluated 243 consecutive patients who received enhanced CT or intravenous pyelography imaging and then underwent abdominal CT imaging within 5 days. According to the interval between imaging, the patients were divided into group A (1 day, group B (2 or 3 days, and group C (4 or 5 days. Three radiologists evaluated CT images to determine GBO. Fisher’s exact test and multivariate backward stepwise elimination logistic regression were performed.Results: Positive GBO was significantly associated with the interval between imaging studies, contrast type, contrast volume, renal function, and hypertransaminasemia (P<0.05. Multivariate backward stepwise elimination logistic regression analysis of the three groups identified contrast type and hypertransaminasemia as independent predictors of GBO in group B patients (odds ratio [OR], 13.52, 95% confidence interval [CI

  12. Comparison of 25-gauge sutureless vitrectomy and 20-gauge vitrectomy in the treatment of posterior capsule opacification in pseudophakic children

    Directory of Open Access Journals (Sweden)

    Xiao-Ming Wu

    2015-12-01

    Full Text Available AIM: To compare the effectiveness and safety of pars plana capsulotomy and vitrectomy using 25-gauge tansconjunctival sutureless vitrectomy system and 20-gauge vitrectomy system for posterior capsule opacification (PCO in pseudophakic children. METHODS: Retrospectively study. Pars plana capsulotomy and vitrectomy using 25-gauge sutureless vitrectomy system was performed for PCO in the study group (32 eyes. Patients in the control group (34 eyes underwent capsulotomy and vitrectomy using standard 20-gauge vitrectomy system, providing a comparison between 2 groups with regard to preoperative and postoperative best corrected visual acuity (BCVA, intraocular pressure (IOP, and intraoperative and postoperative complications. The two groups were performed consequentially. The patients ages ranged from 2 to 13y (means: 6.61±2.73y. Surgical technique, intraoperative and postoperative complications, visual acuity, IOP, and recurrent PCO were recorded. RESULTS: The surgical procedure was performed uneventfully in all patients. Visual acuity improved significantly in both groups. BCVA improved in 22 eyes (81.5% in the study group and in 28 eyes (87.5% in the control group. There was no statistical difference of visual acuity that were attainable in two groups (H=0.115, P=0.909. Mean postoperative IOP showed no significant difference between the groups at 1wk. All sort of PCO were accomplished by 20-gauge system, while 25-gauge system was effective for pearls style and 2 grade of fibrous PCO, and was insufficient to grade 3 of PCO. In the study group two cases were not accomplished by 25-gauge system while 20-gauge system conquered them. Compared with the control group, mean operative time for opening and closing the sclerotomy in the study group was considerably reduced. The mean follow-up was 38.2mo (range: 8-79mo. During the follow-up period, no incision leakage, corneal edema, vitreous loss, IOL damage, retinal detachment, recurrent PCO, or other

  13. Findings of an experimental study in a rabbit model on posterior capsule opacification after implantation of hydrophobic acrylic and hydrophilic acrylic intraocular lenses

    Directory of Open Access Journals (Sweden)

    Nikolaos Trakos

    2009-01-01

    Full Text Available Nikolaos Trakos1, Elli Ioachim2, Elena Tsanou2, Miltiadis Aspiotis1, Konstantinos Psilas1, Chris Kalogeropoulos11University Eye Clinic of Ioannina, Ioannina, Greece; 2Pathology Department, University of Ioannina, Ioannina, GreecePurpose: Study on cell growth on the posterior capsule after implantation of hydrophobic acrylic (Acrysof SA 60 AT and hydrophilic acrylic (Akreos Disc intraocular lenses (IOL in a rabbit model and comparison of posterior capsule opacification (PCO.Methods: Phacoemulsification was performed in 22 rabbit eyes, and two different IOL types (Acrysof SA60 AT and Akreos Disc were implanted. These IOLs had the same optic geometry (square edged but different material and design. Central PCO (CPCO, peripheral PCO (PPCO, Sommering’s ring (SR formation, type of growth, extension of PCO, cell type, inhibition, and fibrosis were evaluated three weeks after surgery. Histological sections of each globe were prepared to document the evaluation of PCO.Results: No statistically significant difference was observed between a hydrophobic acrylic IOL and a hydrophilic acrylic IOL in relation to the CPCO, PPCO, type of growth, extension, cell type, inhibition, and fibrosis. Statistically significant difference was observed in relation to the formation of SR with Acrysof SA 60 AT group presenting more SR than Akreos Disc group.Conclusion: PCO was not influenced by the material of the IOL or the design of the haptics of the IOLs we studied.Keywords: posterior capsule opacification, intraocular lenses, rabbit model

  14. Comparison of posterior capsule opacification at 360-degree square edge hydrophilic and sharp edge hydrophobic acrylic intraocular lens in diabetic patients

    Institute of Scientific and Technical Information of China (English)

    Ling; Bai; Jin; Zhang; Ling; Chen; Ting; Ma; Hou-Cheng; Liang

    2015-01-01

    ·AIM: To compare posterior capsule opacification(PCO)degree and visual functions after phacoemulsification in eyes implanted with 360-degree square edge hydrophilic acrylic intraocular lens(IOL)(570C C-flex, Rayner) and sharp edge hydrophobic acrylic IOL(Sensar AR40 e,AMO) in diabetic patients.· METHODS: Sixty diabetic patients underwent uneventful phacoemulsification and randomly implanted one of the two IOLs. The PCO value was measured by retroillumination photographs and Evaluation of Posterior Capsule Opacification(EPCO) 2000 image-analysis software at 1, 6, 12, and 24 mo after surgery. Visual acuity, and contrast sensitivity in photopic and mesopic conditions were also examined at each follow up time point. The incidence of eye that required Nd:YAG laser posterior capsulotomy were also compared.·RESULTS: There was not any statistically significant difference in PCO scores between Rayner C-flex 570 C group and Sensar AR40 e group at each follow up time point. Visual acuity, Nd:YAG capsulotomy incidence and contrast sensitivity also had no significant difference during the 24 mo follow-up.·CONCLUSION: For diabetic patients, Rayner 570 C Cflex and Sensar AR40 e IOLs are same effective for prevent PCO. The 360-degree square edge design maybe is a good alternative technique to improve PCO prevention.

  15. Incidence of posterior capsule opacification following the implantation of a foldable hydrophilic acrylic intraocular lens: a 4 year follow-up study

    Directory of Open Access Journals (Sweden)

    Priscilla de Almeida Jorge

    2014-08-01

    Full Text Available Purpose: To evaluate the incidence of posterior capsule opacification (PCO four years after the implantation of a hydrophilic acrylic intraocular lens (IOL. Methods: Fifty-eight randomly selected eyes from 58 patients were analyzed four years after phacoemulsification and Ioflex IOL implantation. The patients underwent an ophthalmic examination to detect PCO and a detailed medical history was obtained. The patients' charts were reviewed for their corrected distance visual acuity prior to the IOL implantation, as well as for one month postoperatively. The Student's t-test was used for statistical analysis. Results: The mean age of patients without PCO was 74.6 ± 9.5 years, compared to 70.3 ± 15 years in patients with PCO. Four years after surgery, 39 of the 58 eyes (67% had detectable PCO and 24 eyes (41.3% had decreased visual acuity (VA due to PCO. These patients were referred for Nd:YAG laser capsulotomy. Three patients (5.1% had decreased VA due to glaucoma, IOL opacification, or age-related macular degeneration. Twelve eyes (20.7% presented mild PCO with unchanged VA. Systemic arterial hypertension was reported by 45% of the patients, and in 3.5% of these cases this was associated with diabetes mellitus. Conclusion: This study found the incidence of PCO to be 67% four years after phacoemulsification and Ioflex IOL implantation.

  16. Types of Pulmonary Hypertension

    Science.gov (United States)

    ... from the NHLBI on Twitter. Types of Pulmonary Hypertension The World Health Organization divides pulmonary hypertension (PH) ... are called pulmonary hypertension.) Group 1 Pulmonary Arterial Hypertension Group 1 PAH includes: PAH that has no ...

  17. Constructing dense genetic linkage maps

    NARCIS (Netherlands)

    Jansen, J.; Jong, de A.G.; Ooijen, van J.W.

    2001-01-01

    This paper describes a novel combination of techniques for the construction of dense genetic linkage maps. The construction of such maps is hampered by the occurrence of even small proportions of typing errors. Simulated annealing is used to obtain the best map according to the optimality criterion:

  18. Method for dense packing discovery.

    Science.gov (United States)

    Kallus, Yoav; Elser, Veit; Gravel, Simon

    2010-11-01

    The problem of packing a system of particles as densely as possible is foundational in the field of discrete geometry and is a powerful model in the material and biological sciences. As packing problems retreat from the reach of solution by analytic constructions, the importance of an efficient numerical method for conducting de novo (from-scratch) searches for dense packings becomes crucial. In this paper, we use the divide and concur framework to develop a general search method for the solution of periodic constraint problems, and we apply it to the discovery of dense periodic packings. An important feature of the method is the integration of the unit-cell parameters with the other packing variables in the definition of the configuration space. The method we present led to previously reported improvements in the densest-known tetrahedron packing. Here, we use the method to reproduce the densest-known lattice sphere packings and the best-known lattice kissing arrangements in up to 14 and 11 dimensions, respectively, providing numerical evidence for their optimality. For nonspherical particles, we report a dense packing of regular four-dimensional simplices with density ϕ=128/219≈0.5845 and with a similar structure to the densest-known tetrahedron packing.

  19. Unconditional Continuous Variable Dense Coding

    CERN Document Server

    Ralph, T C

    2002-01-01

    We investigate the conditions under which unconditional dense coding can be achieved using continuous variable entanglement. We consider the effect of entanglement impurity and detector efficiency and discuss experimental verification. We conclude that the requirements for a strong demonstration are not as stringent as previously thought and are within the reach of present technology.

  20. The CT appearances of delayed amniotic fluid clearance from the lungs in an infant with absent pulmonary valve and congenital lobar emphysema

    Energy Technology Data Exchange (ETDEWEB)

    Fink, A. Michelle [Royal Children' s Hospital, Department of Medical Imaging, Parkville, Victoria (Australia); University of Melbourne, Melbourne, Victoria (Australia); Edis, Brian [Royal Children' s Hospital, Department of Cardiology, Parkville, Victoria (Australia); Massie, John [University of Melbourne, Melbourne, Victoria (Australia); Royal Children' s Hospital, Department of Respiratory Medicine, Parkville, Victoria (Australia); Murdoch Children' s Research Institute, Melbourne, Victoria (Australia)

    2005-09-01

    Congenital lobar emphysema (CLE) is a cause of severe neonatal respiratory distress. Overexpansion of the affected pulmonary lobe in the fetus is due to narrowing of the airway, with a resultant 'ball-valve' effect. At birth, there may be delayed clearance of fetal lung fluid. Early chest radiographs show opacification of the hyperexpanded lobe. The CT findings in the immediate neonatal period have not been previously reported. We describe the imaging in a neonate with tetralogy of Fallot and absent pulmonary valve with secondary CLE. CT demonstrates the hyperexpanded lobe with initial thickening of the interlobular septa and alveolar ground glass attenuation, with subsequent clearing. This resorption of fetal lung fluid via the pulmonary interstitium should not be confused with interstitial lung disease. (orig.)

  1. Warm Dense Matter: An Overview

    Energy Technology Data Exchange (ETDEWEB)

    Kalantar, D H; Lee, R W; Molitoris, J D

    2004-04-21

    This document provides a summary of the ''LLNL Workshop on Extreme States of Materials: Warm Dense Matter to NIF'' which was held on 20, 21, and 22 February 2002 at the Wente Conference Center in Livermore, CA. The warm dense matter regime, the transitional phase space region between cold material and hot plasma, is presently poorly understood. The drive to understand the nature of matter in this regime is sparking scientific activity worldwide. In addition to pure scientific interest, finite temperature dense matter occurs in the regimes of interest to the SSMP (Stockpile Stewardship Materials Program). So that obtaining a better understanding of WDM is important to performing effective experiments at, e.g., NIF, a primary mission of LLNL. At this workshop we examined current experimental and theoretical work performed at, and in conjunction with, LLNL to focus future activities and define our role in this rapidly emerging research area. On the experimental front LLNL plays a leading role in three of the five relevant areas and has the opportunity to become a major player in the other two. Discussion at the workshop indicated that the path forward for the experimental efforts at LLNL were two fold: First, we are doing reasonable baseline work at SPLs, HE, and High Energy Lasers with more effort encouraged. Second, we need to plan effectively for the next evolution in large scale facilities, both laser (NIF) and Light/Beam sources (LCLS/TESLA and GSI) Theoretically, LLNL has major research advantages in areas as diverse as the thermochemical approach to warm dense matter equations of state to first principles molecular dynamics simulations. However, it was clear that there is much work to be done theoretically to understand warm dense matter. Further, there is a need for a close collaboration between the generation of verifiable experimental data that can provide benchmarks of both the experimental techniques and the theoretical capabilities

  2. Microwave Ablation of Pulmonary Malignancies Using a Novel High-energy Antenna System

    Energy Technology Data Exchange (ETDEWEB)

    Little, Mark W.; Chung, Daniel; Boardman, Philip; Gleeson, Fergus V.; Anderson, Ewan M., E-mail: ewan.anderson@ouh.nhs.uk [Churchill Hospital, Department of Radiology (United Kingdom)

    2013-04-15

    To evaluate the technical success, safety, and imaging follow-up of malignant pulmonary nodules treated with a novel high-energy percutaneous microwave ablation (MWA) system. Between July 2010 and September 2011, a total of 23 patients, 12 men, mean age 68 (range 30-87) years with 29 pulmonary malignancies of median diameter 19 (range 8-57) mm, underwent computed tomography (CT)-guided MWA with a 16G microwave needle antenna enabling power up to 180 W. Technical success was defined as needle placement in the intended lesion without death or serious injury. Adequacy of ablation was assessed at 24 h on contrast-enhanced CT. Circumferential solid or ground glass opacification >5 mm was used to define an ideal ablation. Local tumor recurrence was assessed at 1, 3, and 6 months after ablation on contrast-enhanced CT. MWA was technically successful in 93 % (n = 27). Mean ablation duration was 3.6 (range 1-9) min. Ten patients (43 %) developed a pneumothorax as a result of the MWA; only 3 (13 %) required placement of a chest drain. Thirty-day mortality rate was 0 %. The mean hospital stay was 1.5 (range 1-7) days. A total of 22 lesions (75 %) were surrounded by {>=}5 mm ground glass or solid opacification after the procedure. At a median follow-up of 6 months, local recurrence was identified in 3 out of 26 lesions, giving a local control rate of 88 %. MWA using a high-power antenna of pulmonary malignancies is safe, technically achievable, and enables fast ablation times.

  3. Proton MRI in the evaluation of pulmonary sarcoidosis: Comparison to chest CT

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Jonathan H., E-mail: chungj@njhealth.org [Radiology, National Jewish Health, Denver, CO (United States); Little, Brent P., E-mail: bplittle2@hotmail.com [Radiology, Emory University School of Medicine, Atlanta, GA (United States); Forssen, Anna V., E-mail: ForssenA@NJHealth.org [Division of Biostatistics and Bioinformatics, National Jewish Health, Denver, CO (United States); Yong, Jin, E-mail: JinG@NJHealth.org [Radiology, National Jewish Health, Denver, CO (United States); Diagnostic Radiology, Chonbuk National University Medical School, Jeonbuk (Korea, Republic of); Nambu, Atsushi, E-mail: nambu-a@gray.plala.or.jp [Radiology, National Jewish Health, Denver, CO (United States); Radiology, University of Yamanashi, Chuo City (Japan); Kazlouski, Demitry, E-mail: demitry.kazlouski@gmail.com [Radiology, National Jewish Health, Denver, CO (United States); Puderbach, Michael, E-mail: m.puderbach@dkfz-heidelberg.de [Diagnostic and Interventional Radiology, Chest Clinics at University Hospital, Heidelberg (Germany); Biederer, Juergen, E-mail: juergen.biederer@uni-heidelberg.de [Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg (Germany); Lynch, David A., E-mail: LynchD@NJHealth.org [Radiology, National Jewish Health, Denver, CO (United States)

    2013-12-01

    Purpose: The purpose of this study was to determine the feasibility of proton MRI of the lung in sarcoidosis patients and the agreement between the imaging appearance of pulmonary sarcoidosis on MRI and CT. Materials and methods: Chest CT scans and dedicated pulmonary MRI scans (including HASTE, VIBE, and TrueFISP sequences) were performed within 90 days of each other in 29 patients. The scans were scored for gross parenchymal opacification, reticulation, nodules, and masses using a 3-point lobar scale. Total and subset scores for corresponding MRI and CT scans were compared using the Spearman correlation test, Bland–Altman plots, and Cohen's quadratic-weighted kappa analysis. MRI scores were compared to CT by lobe and disease category, using percentage agreement, Spearman rank correlation, and Cohen's quadratic-weighted kappa. Results: The mean (±s.d.) time between MRI and CT scans was 33 ± 32 days. There was substantial correlation and agreement between total disease scoring on MRI and CT with a Spearman correlation coefficient of 0.774 (p < 0.0001) and a Cohen's weighted kappa score of 0.646. Correlation and agreement were highest for gross parenchymal opacification (0.695, 0.528) and reticulation (0.609, 0.445), and lowest in the setting of nodules (0.501, 0.305). Agreement testing was not performed for mass scores due to low prevalence. Upper lobe scoring on MRI and CT demonstrated greater agreement compared to the lower lobes (average difference in Cohen's weighted kappa score of 0.112). Conclusion: There is substantial correlation and agreement between MRI and CT in the scoring of pulmonary sarcoidosis, though MRI evaluation in the upper lobes may be more accurate than in the lower lobes.

  4. Structural Transitions in Dense Networks

    CERN Document Server

    Lambiotte, R; Bhat, U; Redner, S

    2016-01-01

    We introduce an evolving network model in which a new node attaches to a randomly selected target node and also to each of its neighbors with probability $p$. The resulting network is sparse for $p<\\frac{1}{2}$ and dense (average degree increasing with number of nodes $N$) for $p\\geq \\frac{1}{2}$. In the dense regime, individual networks realizations built by this copying mechanism are disparate and not self-averaging. Further, there is an infinite sequence of structural anomalies at $p=\\frac{2}{3}$, $\\frac{3}{4}$, $\\frac{4}{5}$, etc., where the dependences on $N$ of the number of triangles (3-cliques), 4-cliques, undergo phase transitions. When linking to second neighbors of the target can occur, the probability that the resulting graph is complete---where all nodes are connected---is non-zero as $N\\to\\infty$.

  5. Holographic Renormalization in Dense Medium

    Directory of Open Access Journals (Sweden)

    Chanyong Park

    2014-01-01

    describes a dense medium at finite temperature, is investigated in this paper. In a dense medium, two different thermodynamic descriptions are possible due to an additional conserved charge. These two different thermodynamic ensembles are classified by the asymptotic boundary condition of the bulk gauge field. It is also shown that in the holographic renormalization regularity of all bulk fields can reproduce consistent thermodynamic quantities and that the Bekenstein-Hawking entropy is nothing but the renormalized thermal entropy of the dual field theory. Furthermore, we find that the Reissner-Nordström AdS black brane is dual to a theory with conformal matter as expected, whereas a charged black brane with a nontrivial dilaton profile is mapped to a theory with nonconformal matter although its leading asymptotic geometry still remains as AdS space.

  6. Radiative properties of dense nanofluids.

    Science.gov (United States)

    Wei, Wei; Fedorov, Andrei G; Luo, Zhongyang; Ni, Mingjiang

    2012-09-01

    The radiative properties of dense nanofluids are investigated. For nanofluids, scattering and absorbing of electromagnetic waves by nanoparticles, as well as light absorption by the matrix/fluid in which the nanoparticles are suspended, should be considered. We compare five models for predicting apparent radiative properties of nanoparticulate media and evaluate their applicability. Using spectral absorption and scattering coefficients predicted by different models, we compute the apparent transmittance of a nanofluid layer, including multiple reflecting interfaces bounding the layer, and compare the model predictions with experimental results from the literature. Finally, we propose a new method to calculate the spectral radiative properties of dense nanofluids that shows quantitatively good agreement with the experimental results.

  7. Dilatons for Dense Hadronic Matter

    CERN Document Server

    Lee, Hyun Kyu

    2009-01-01

    The idea that the explicit breaking of scale invariance by the trace anomaly of QCD can be rephrased as a spontaneous breaking has been recently exploited to capture the low-energy strong interaction dynamics of dense (and also hot) matter in terms of two dilaton fields, the "soft" (chi_s) and the "hard" (chi_h) fields, in the frame work of the hidden local gauge symmetry. In the Freund-Nambu model, the spontaneous symmetry breaking of scale symmetry is induced by an explicitly breaking term, while the spontaneous symmetry breaking is possible in the flat potential model which is scale symmetric. We discuss the interplay of the soft and hard dilatons using the spontaneously broken scale symmetry schemes and uncover a novel structure of dense matter hitherto unexplored.

  8. Pulmonary hypertension complicating pulmonary sarcoidosis

    NARCIS (Netherlands)

    Huitema, M P; Grutters, J C; Rensing, B J W M; Reesink, H J; Post, M C

    Pulmonary hypertension (PH) is a severe complication of sarcoidosis, with an unknown prevalence. The aetiology is multifactorial, and the exact mechanism of PH in the individual patient is often difficult to establish. The diagnostic work-up and treatment of PH in sarcoidosis is complex, and should

  9. Pulmonary hypertension complicating pulmonary sarcoidosis

    NARCIS (Netherlands)

    Huitema, M P; Grutters, J C; Rensing, B J W M; Reesink, H J; Post, M C

    2016-01-01

    Pulmonary hypertension (PH) is a severe complication of sarcoidosis, with an unknown prevalence. The aetiology is multifactorial, and the exact mechanism of PH in the individual patient is often difficult to establish. The diagnostic work-up and treatment of PH in sarcoidosis is complex, and should

  10. Pulmonary CT angiography protocol adapted to the hemodynamic effects of pregnancy.

    LENUS (Irish Health Repository)

    Ridge, Carole A

    2012-02-01

    OBJECTIVE: The purpose of this study was to compare the image quality of a standard pulmonary CT angiography (CTA) protocol with a pulmonary CTA protocol optimized for use in pregnant patients with suspected pulmonary embolism (PE). MATERIALS AND METHODS: Forty-five consecutive pregnant patients with suspected PE were retrospectively included in the study: 25 patients (group A) underwent standard-protocol pulmonary CTA and 20 patients (group B) were imaged using a protocol modified for pregnancy. The modified protocol used a shallow inspiration breath-hold and a high concentration, high rate of injection, and high volume of contrast material. Objective image quality and subjective image quality were evaluated by measuring pulmonary arterial enhancement, determining whether there was transient interruption of the contrast bolus by unopacified blood from the inferior vena cava (IVC), and assessing diagnostic adequacy. RESULTS: Objective and subjective image quality were significantly better for group B-that is, for the group who underwent the CTA protocol optimized for pregnancy. Mean pulmonary arterial enhancement and the percentage of studies characterized as adequate for diagnosis were higher in group B than in group A: 321 +\\/- 148 HU (SD) versus 178 +\\/- 67 HU (p = 0.0001) and 90% versus 64% (p = 0.05), respectively. Transient interruption of contrast material by unopacified blood from the IVC was observed more frequently in group A (39%) than in group B (10%) (p = 0.05). CONCLUSION: A pulmonary CTA protocol optimized for pregnancy significantly improved image quality by increasing pulmonary arterial opacification, improving diagnostic adequacy, and decreasing transient interruption of the contrast bolus by unopacified blood from the IVC.

  11. Constructing Dense Graphs with Unique Hamiltonian Cycles

    Science.gov (United States)

    Lynch, Mark A. M.

    2012-01-01

    It is not difficult to construct dense graphs containing Hamiltonian cycles, but it is difficult to generate dense graphs that are guaranteed to contain a unique Hamiltonian cycle. This article presents an algorithm for generating arbitrarily large simple graphs containing "unique" Hamiltonian cycles. These graphs can be turned into dense graphs…

  12. Pulmonary Arterial Hypertension

    Science.gov (United States)

    Pulmonary Arterial Hypertension What Is Pulmonary Hypertension? To understand pulmonary hypertension (PH) it helps to understand how blood ows throughout your body. While the heart is one organ, it ...

  13. Congenital syphilis associated with persistent pulmonary ...

    African Journals Online (AJOL)

    involvement, right upper lobe opacification and an increased ... aminotransferase (ALT) 45 U/I, lactate dehydrogenase (LDH). 1 931 U/I and alkaline ... echocardiography which showed right-to-Ieft shunting .... United States, 1981 through 1989.

  14. Probing Cold Dense Nuclear Matter

    Energy Technology Data Exchange (ETDEWEB)

    Subedi, Ramesh; Shneor, R.; Monaghan, Peter; Anderson, Bryon; Aniol, Konrad; Annand, John; Arrington, John; Benaoum, Hachemi; Benmokhtar, Fatiha; Bertozzi, William; Boeglin, Werner; Chen, Jian-Ping; Choi, Seonho; Cisbani, Evaristo; Craver, Brandon; Frullani, Salvatore; Garibaldi, Franco; Gilad, Shalev; Gilman, Ronald; Glamazdin, Oleksandr; Hansen, Jens-Ole; Higinbotham, Douglas; Holmstrom, Timothy; Ibrahim, Hassan; Igarashi, Ryuichi; De Jager, Cornelis; Jans, Eddy; Jiang, Xiaodong; Kaufman, Lisa; Kelleher, Aidan; Kolarkar, Ameya; Kumbartzki, Gerfried; LeRose, John; Lindgren, Richard; Liyanage, Nilanga; Margaziotis, Demetrius; Markowitz, Pete; Marrone, Stefano; Mazouz, Malek; Meekins, David; Michaels, Robert; Moffit, Bryan; Perdrisat, Charles; Piasetzky, Eliazer; Potokar, Milan; Punjabi, Vina; Qiang, Yi; Reinhold, Joerg; Ron, Guy; Rosner, Guenther; Saha, Arunava; Sawatzky, Bradley; Shahinyan, Albert; Sirca, Simon; Slifer, Karl; Solvignon, Patricia; Sulkosky, Vince; Sulkosky, Vincent; Sulkosky, Vince; Sulkosky, Vincent; Urciuoli, Guido; Voutier, Eric; Watson, John; Weinstein, Lawrence; Wojtsekhowski, Bogdan; Wood, Stephen; Zheng, Xiaochao; Zhu, Lingyan

    2008-06-01

    The protons and neutrons in a nucleus can form strongly correlated nucleon pairs. Scattering experiments, in which a proton is knocked out of the nucleus with high-momentum transfer and high missing momentum, show that in carbon-12 the neutron-proton pairs are nearly 20 times as prevalent as proton-proton pairs and, by inference, neutron-neutron pairs. This difference between the types of pairs is due to the nature of the strong force and has implications for understanding cold dense nuclear systems such as neutron stars.

  15. Probing Cold Dense Nuclear Matter

    CERN Document Server

    Subedi, R; Monaghan, P; Anderson, B D; Aniol, K; Annand, J; Arrington, J; Benaoum, H; Benmokhtar, F; Bertozzi, W; Boeglin, W; Chen, J -P; Choi, Seonho; Cisbani, E; Craver, B; Frullani, S; Garibaldi, F; Gilad, S; Gilman, R; Glamazdin, O; Hansen, J -O; Higinbotham, D W; Holmstrom, T; Ibrahim, H; Igarashi, R; De Jager, C W; Jans, E; Jiang, X; Kaufman, L; Kelleher, A; Kolarkar, A; Kumbartzki, G; LeRose, J J; Lindgren, R; Liyanage, N; Margaziotis, D J; Markowitz, P; Marrone, S; Mazouz, M; Meekins, D; Michaels, R; Moffit, B; Perdrisat, C F; Piasetzky, E; Potokar, M; Punjabi, V; Qiang, Y; Reinhold, J; Ron, G; Rosner, G; Saha, A; Sawatzky, B; Shahinyan, A; Širca, S; Slifer, K; Solvignon, P; Sulkosky, V; Urciuoli, G; Voutier, E; Watson, J W; Weinstein, L B; Wojtsekhowski, B; Wood, S; Zheng, X -C; Zhu, L; 10.1126/science.1156675

    2009-01-01

    The protons and neutrons in a nucleus can form strongly correlated nucleon pairs. Scattering experiments, where a proton is knocked-out of the nucleus with high momentum transfer and high missing momentum, show that in 12C the neutron-proton pairs are nearly twenty times as prevalent as proton-proton pairs and, by inference, neutron-neutron pairs. This difference between the types of pairs is due to the nature of the strong force and has implications for understanding cold dense nuclear systems such as neutron stars.

  16. Dilatons in Dense Baryonic Matter

    CERN Document Server

    Lee, Hyun Kyu

    2013-01-01

    We discuss the role of dilaton, which is supposed to be representing a special feature of scale symmetry of QCD, trace anomaly, in dense baryonic matter. The idea that the scale symmetry breaking of QCD is responsible for the spontaneous breaking of chiral symmetry is presented along the similar spirit of Freund-Nambu model. The incorporation of dilaton field in the hidden local symmetric parity doublet model is briefly sketched with the possible role of dilaton at high density baryonic matter, the emergence of linear sigma model in dilaton limit.

  17. Interstitial Pulmonary Edema Following Bromocarbamide Intoxication

    Science.gov (United States)

    Sugihara, H.; Hagedorn, M.; Bōttcher, D.; Neuhof, H.; Mittermayer, Ch.

    1974-01-01

    Bromocarbamides are sleep-inducing drugs which can lead, in man, to intoxication and death due to respiratory failure. To prove whether hemodynamic factors or the changed endothelial permeability induce pulmonary edema, animal experiments were performed. The fine structural changes in pulmonary edema in rabbits were observed at 60, 90 and 120 minutes after oral administration. The major findings were a) large blebs between capillary endothelium and alveolar epithelium and b) interstitial edema of the vessel wall. The bleb contents were much less electron dense than the blood contents in the capillary. Colloidal carbon did not enter the bleb or the edematous interstitial tissue. Exogenous peroxidase uptake in pinocytotie vesicles increased in pathologic cases. The hemodynamic measurements in animal receiving artificial respiration which maintained the blood pO2 at a steady state showed similar blebs in the pulmonary vessels, indicating that anoxia is not the major cause of the vascular lesion. Moreover, pulmonary arterial pressure and pulmonary vascular resistance could be held in the normal range in artificially respirated animals under bromocarbamide intoxication. Thus, hemodynamic factors are not likely to play a pathogenetic role in bringing about pulmonary edema. The chief, early factor is the increased endothelial permeability due to increased cytoplasmic transport. From this a practical suggestion for treating patients with bromocarbamide intoxication is derived: the usual fluid replacement in shock patients should be handled with great care to avoid fluid overload of the lung. ImagesFig 1Fig 2Fig 3Fig 4Fig 5Fig 6 PMID:4835993

  18. How Is Pulmonary Hypertension Treated?

    Science.gov (United States)

    ... from the NHLBI on Twitter. How Is Pulmonary Hypertension Treated? Pulmonary hypertension (PH) has no cure. However, ... Types of Pulmonary Hypertension." ) Group 1 Pulmonary Arterial Hypertension Group 1 pulmonary arterial hypertension (PAH) includes PH ...

  19. Pulmonary arterial hypertension : an update

    NARCIS (Netherlands)

    Hoendermis, E. S.

    2011-01-01

    Pulmonary arterial hypertension (PAH), defined as group 1 of the World Heart Organisation (WHO) classification of pulmonary hypertension, is an uncommon disorder of the pulmonary vascular system. It is characterised by an increased pulmonary artery pressure, increased pulmonary vascular resistance

  20. Simple pulmonary eosinophilia

    Science.gov (United States)

    Pulmonary infiltrates with eosinophilia; Loffler syndrome; Eosinophilic pneumonia; Pneumonia - eosinophilic ... A rare complication of simple pulmonary eosinophilia is a severe type of pneumonia called acute idiopathic eosinophilic pneumonia.

  1. [Pulmonary strongyloidiasis].

    Science.gov (United States)

    Lozada, Heiler; Daza, Jorge E

    2016-10-01

    Strongyloidiasis is an infection caused by the parasite Strongyloides stercoralis, which can be asymptomatic and means a high morbidity and mortality in immunocompromised hosts, severe malnutrition and coinfection with HTLV-1 virus. The parasite has the potential to produce and multiply internal autoinfection in humans, thus an hyperinfection can be developed. A case of pulmonary infection by this parasite is presented in this study, infection which advanced into a respiratory failure and required mechanical ventilation and hemodynamic support in an intensive care unit. The standard treatment combined with ivermectin and albendazole was provided, achieving an appropriate response.

  2. Simultaneous bilateral contrast injection in computed tomography pulmonary angiography

    Energy Technology Data Exchange (ETDEWEB)

    Bulla, Stefan; Pache, Gregor; Langer, Mathias; Blanke, Philipp (Department of Diagnostic Radiology, University Hospital Freiburg (Germany)), Email: stefan.bulla@uniklinik-freiburg.de; Bley, Thorsten (Department of Diagnostic Radiology, University Hospital Hamburg (Germany))

    2012-02-15

    Background. Computed tomography pulmonary angiography (CTPA) has evolved as the gold standard for diagnosing pulmonary embolism. However, subsegmental arteries are often not assessed to do insufficient attenuation. Purpose. To evaluate the influence of simultaneous bilateral versus unilateral injection of a fixed amount of contrast media on pulmonary artery opacification and image quality in CTPA. Material and Methods. In this institutional review board-approved prospective study, 180 patients (91 women, mean age 61.9 +- 16.5 years) referred for CTPA (100 kV) due to suspected pulmonary embolism were randomized in groups of 45 patients each, with either unilateral (A:4 mL/s; B:6 mL/s) or bilateral (C: 6 mL/s; D: 8 mL/s) (Y-shaped line) injection of 50 mL contrast media. Attenuation was assessed including the subsegmental arteries (4th order). Image quality was evaluated by two readers in consensus using a three-point grading scale (3 = excellent image quality, no artifacts, 1 = non-diagnostic). Results. Mean pulmonary artery attenuation was significantly higher with bilateral injection (1st to 3rd order: A: 303.6 +- 8.8HU; B: 371.1 +- 11.0HU vs. C: 443.2 +- 24.1HU; D: 562.3 +- 15.3HU, P < 0.001). Evaluation of subsegmental arteries was feasible for all patients in groups B-D, but only in 36/45 (80%) patients in group A. Subsegmental attenuation was significantly higher with bilateral injection (A: 284.7 +- 12.1HU; B: 367.4 +- 12.1HU vs. C: 494.2 +- 21.5HU; D: 562.3 +- 26.7HU, P < 0.001). Image quality was diagnostic for all patients but best for group C (A: 2.15 +- 0.4; B: 2.14 +- 0.5; C: 2.92 +- 0.3, and D: 2.51 +- 0.5). Conclusion. Using the same amount of contrast media, bilateral injection yields higher pulmonary artery attenuation and better image quality than unilateral injection. This technique may improve subsegmental pulmonary artery assessment

  3. Idiopathic pulmonary fibrosis

    Directory of Open Access Journals (Sweden)

    Noble Paul W

    2008-03-01

    Full Text Available Abstract Idiopathic pulmonary fibrosis (IPF is a non-neoplastic pulmonary disease that is characterized by the formation of scar tissue within the lungs in the absence of any known provocation. IPF is a rare disease which affects approximately 5 million persons worldwide. The prevalence is estimated to be slightly greater in men (20.2/100,000 than in women (13.2/100,000. The mean age at presentation is 66 years. IPF initially manifests with symptoms of exercise-induced breathless and dry coughing. Auscultation of the lungs reveals early inspiratory crackles, predominantly located in the lower posterior lung zones upon physical exam. Clubbing is found in approximately 50% of IPF patients. Cor pulmonale develops in association with end-stage disease. In that case, classic signs of right heart failure may be present. Etiology remains incompletely understood. Some environmental factors may be associated with IPF (cigarette smoking, exposure to silica and livestock. IPF is recognized on high-resolution computed tomography by peripheral, subpleural lower lobe reticular opacities in association with subpleural honeycomb changes. IPF is associated with a pathological lesion known as usual interstitial pneumonia (UIP. The UIP pattern consists of normal lung alternating with patches of dense fibrosis, taking the form of collagen sheets. The diagnosis of IPF requires correlation of the clinical setting with radiographic images and a lung biopsy. In the absence of lung biopsy, the diagnosis of IPF can be made by defined clinical criteria that were published in guidelines endorsed by several professional societies. Differential diagnosis includes other idiopathic interstitial pneumonia, connective tissue diseases (systemic sclerosis, polymyositis, rheumatoid arthritis, forme fruste of autoimmune disorders, chronic hypersensitivity pneumonitis and other environmental (sometimes occupational exposures. IPF is typically progressive and leads to significant

  4. [Idiopathic pulmonary hemosiderosis with dendriform pulmonary ossification].

    Science.gov (United States)

    Barrera, Ana Madeleine; Vargas, Leslie

    2016-12-01

    Pulmonary ossification is a rare and usually asymptomatic finding reported as incidental in lung biopsies. Similarly, idiopathic pulmonary hemosiderosis is a rare cause of pulmonary infiltrates. We report the case of a 64-year old man with chronic respiratory symptoms in whom these two histopathological findings converged.

  5. Pulmonary biomarkers in chronic obstructive pulmonary disease

    NARCIS (Netherlands)

    Barnes, Peter J.; Chowdhury, Badrul; Kharitonov, Sergei A.; Magnussen, Helgo; Page, Clive P.; Postma, Dirkje; Saetta, Marina

    2006-01-01

    There has been increasing interest in using pulmonary biomarkers to understand and monitor the inflammation in the respiratory tract of patients with chronic obstructive pulmonary disease (COPD). In this Pulmonary Perspective we discuss the merits of the various approaches by reviewing the current l

  6. Contrast enhanced chest-MDCT in oncologic patients. Prospective evaluation of the prevalence of incidental pulmonary embolism and added value of thin reconstructions

    Energy Technology Data Exchange (ETDEWEB)

    Tresoldi, Silvia; Flor, Nicola [Azienda Ospedaliera San Paolo, Dipartimento di Radiologia Diagnostica ed Interventistica, Milano (Italy); Luciani, Andrea [Azienda Ospedaliera San Paolo, Oncologia, Dipartimento di Medicina, Milano (Italy); Lombardi, Maria Antonietta; Colombo, Bernardo [Universita degli Studi di Milano, Scuola di Specializzazione in Radiodiagnostica, Facolta di Medicina e Chirurgia, Milano (Italy); Cornalba, Gianpaolo [Azienda Ospedaliera San Paolo, Dipartimento di Radiologia Diagnostica ed Interventistica, Milano (Italy); Universita degli Studi di Milano, Dipartimento di Scienze della Salute, Milano (Italy)

    2015-11-15

    To prospectively assess prevalence/characteristics of clinically unsuspected pulmonary embolism (PE) in cancer patients undergoing follow-up chest MDCT and investigate MDCT protocol. We evaluated 1013 oncologic patients. MDCT images at 5 and 1.25 mm thickness were independently evaluated. Pulmonary artery opacification degree was assessed. Presence, level, and site of PE were reported. Type of malignancy and metastases were reported for PE-positive patients. After excluding 1.4 % (14/1013) of examinations due to inadequate vessel opacification, 999 patients (572 male; mean age:68 ± 12 years; range:26-93 years) entered the study. Prevalence of PE was 5 %. There was significant improvement in the sensitivity for both readers in the evaluation of 1.25 mm compared to 5 mm images (46-50 % to 82-92 %). 30 % (15/51) PE were not described by the radiologist in the prospectively issued report; 53 % (27/51) of PE were segmental, 72.5 % (37/51) unilateral. The right lower lobe was the most involved (59 %). 27 % patients had colon cancer, 18 % lung cancer. Among PE-positive patients (25 male; mean age 70 ± 10 years; range:44-87 years), 25 % (13/51) had lung cancer, 15 % (8/51) colon cancer. Thin reconstructions are essential for PE diagnosis, regardless of reader experience. Regarding oncologic patients, incidental PE diagnosis influences anticoagulation therapy. (orig.)

  7. Viscoelastic behavior of dense microemulsions

    Science.gov (United States)

    Cametti, C.; Codastefano, P.; D'arrigo, G.; Tartaglia, P.; Rouch, J.; Chen, S. H.

    1990-09-01

    We have performed extensive measurements of shear viscosity, ultrasonic absorption, and sound velocity in a ternary system consisting of water-decane-sodium di(2-ethylhexyl)sulfo- succinate(AOT), in the one-phase region where it forms a water-in-oil microemulsion. We observe a rapid increase of the static shear viscosity in the dense microemulsion region. Correspondingly the sound absorption shows unambiguous evidence of a viscoelastic behavior. The absorption data for various volume fractions and temperatures can be reduced to a universal curve by scaling both the absorption and the frequency by the measured static shear viscosity. The sound absorption can be interpreted as coming from the high-frequency tail of the viscoelastic relaxation, describable by a Cole-Cole relaxation formula with unusually small elastic moduli.

  8. Neutrino Oscillations in Dense Matter

    Science.gov (United States)

    Lobanov, A. E.

    2017-03-01

    A modification of the electroweak theory, where the fermions with the same electroweak quantum numbers are combined in multiplets and are treated as different quantum states of a single particle, is proposed. In this model, mixing and oscillations of particles arise as a direct consequence of the general principles of quantum field theory. The developed approach enables one to calculate the probabilities of the processes taking place in the detector at long distances from the particle source. Calculations of higher-order processes, including computation of the contributions due to radiative corrections, can be performed in the framework of the perturbation theory using the regular diagram technique. As a result, the analog to the Dirac-Schwinger equation of quantum electrodynamics describing neutrino oscillations and its spin rotation in dense matter can be obtained.

  9. DPIS for warm dense matter

    Energy Technology Data Exchange (ETDEWEB)

    Kondo, K.; Kanesue, T.; Horioka, K.; Okamura, M.

    2010-05-23

    Warm Dense Matter (WDM) offers an challenging problem because WDM, which is beyond ideal plasma, is in a low temperature and high density state with partially degenerate electrons and coupled ions. WDM is a common state of matter in astrophysical objects such as cores of giant planets and white dwarfs. The WDM studies require large energy deposition into a small target volume in a shorter time than the hydrodynamical time and need uniformity across the full thickness of the target. Since moderate energy ion beams ({approx} 0.3 MeV/u) can be useful tool for WDM physics, we propose WDM generation using Direct Plasma Injection Scheme (DPIS). In the DPIS, laser ion source is connected to the Radio Frequency Quadrupole (RFQ) linear accelerator directly without the beam transport line. DPIS with a realistic final focus and a linear accelerator can produce WDM.

  10. Chronic thromboembolic pulmonary hypertension.

    Science.gov (United States)

    Schölzel, B E; Snijder, R J; Mager, J J; van Es, H W; Plokker, H W M; Reesink, H J; Morshuis, W J; Post, M C

    2014-12-01

    Chronic pulmonary thromboembolic disease is an important cause of severe pulmonary hypertension, and as such is associated with significant morbidity and mortality. The prognosis of this condition reflects the degree of associated right ventricular dysfunction, with predictable mortality related to the severity of the underlying pulmonary hypertension. Left untreated, the prognosis is poor. Pulmonary endarterectomy is the treatment of choice to relieve pulmonary artery obstruction in patients with chronic thromboembolic pulmonary hypertension and has been remarkably successful. Advances in surgical techniques along with the introduction of pulmonary hypertension-specific medication provide therapeutic options for the majority of patients afflicted with the disease. However, a substantial number of patients are not candidates for pulmonary endarterectomy due to either distal pulmonary vascular obstruction or significant comorbidities. Therefore, careful selection of surgical candidates in expert centres is paramount. The current review focuses on the diagnostic approach to chronic thromboembolic pulmonary hypertension and the available surgical and medical therapeutic options.

  11. Apelin and pulmonary hypertension

    DEFF Research Database (Denmark)

    Andersen, Charlotte Uggerhøj; Hilberg, Ole; Mellemkjær, Søren;

    2011-01-01

    Pulmonary arterial hypertension (PAH) is a devastating disease characterized by pulmonary vasoconstriction, pulmonary arterial remodeling, abnormal angiogenesis and impaired right ventricular function. Despite progress in pharmacological therapy, there is still no cure for PAH. The peptide apelin...... vasoconstriction, and has positive inotropic and cardioprotective effects. Apelin attenuates vasoconstriction in isolated rat pulmonary arteries, and chronic treatment with apelin attenuates the development of pulmonary hypertension in animal models. The existing literature thus renders APLNR an interesting...

  12. 5G Ultra-Dense Cellular Networks

    OpenAIRE

    Ge, Xiaohu; Tu, Song; Mao, Guoqiang; Wang, Cheng-xiang; Han, Tao

    2015-01-01

    Traditional ultra-dense wireless networks are recommended as a complement for cellular networks and are deployed in partial areas, such as hotspot and indoor scenarios. Based on the massive multiple-input multi-output (MIMO) antennas and the millimeter wavecommunication technologies, the 5G ultra-dense cellular network is proposed to deploy in overall cellular scenarios. Moreover, a distribution network architecture is presented for 5G ultra-dense cellular networks. Furthermore, the backhaul ...

  13. Interference Coordination for Dense Wireless Networks

    DEFF Research Database (Denmark)

    Soret, Beatriz; Pedersen, Klaus I.; Jørgensen, Niels T.K.

    2015-01-01

    The promise of ubiquitous and super-fast connectivity for the upcoming years will be in large part fulfilled by the addition of base stations and spectral aggregation. The resulting very dense networks (DenseNets) will face a number of technical challenges. Among others, the interference emerges ...... simply react to an identified interference problem. As an example, we propose two algorithms to apply time domain and frequency domain small cell interference coordination in a DenseNet....

  14. HOW GOOD IS A DENSE SHOP SCHEDULE?

    Institute of Scientific and Technical Information of China (English)

    陈礴; 俞文(鱼此)

    2001-01-01

    In this paper, we study a class of simple and easy-to-construct shop schedules, known as dense schedules. We present tight bounds on the maximum deviation in makespan of dense flow-shop and job-shop schedules from their optimal ones. For dense open-shop schedules, we do the same for the special case of four machines and thus add a stronger supporting case for proving a standing conjecture.

  15. Breaking Dense Structures: Proving Stability of Densely Structured Hybrid Systems

    Directory of Open Access Journals (Sweden)

    Eike Möhlmann

    2015-06-01

    Full Text Available Abstraction and refinement is widely used in software development. Such techniques are valuable since they allow to handle even more complex systems. One key point is the ability to decompose a large system into subsystems, analyze those subsystems and deduce properties of the larger system. As cyber-physical systems tend to become more and more complex, such techniques become more appealing. In 2009, Oehlerking and Theel presented a (de-composition technique for hybrid systems. This technique is graph-based and constructs a Lyapunov function for hybrid systems having a complex discrete state space. The technique consists of (1 decomposing the underlying graph of the hybrid system into subgraphs, (2 computing multiple local Lyapunov functions for the subgraphs, and finally (3 composing the local Lyapunov functions into a piecewise Lyapunov function. A Lyapunov function can serve multiple purposes, e.g., it certifies stability or termination of a system or allows to construct invariant sets, which in turn may be used to certify safety and security. In this paper, we propose an improvement to the decomposing technique, which relaxes the graph structure before applying the decomposition technique. Our relaxation significantly reduces the connectivity of the graph by exploiting super-dense switching. The relaxation makes the decomposition technique more efficient on one hand and on the other allows to decompose a wider range of graph structures.

  16. The effect of Nd:YAG laser treatment of posterior capsule opacification on anterior chamber depth and refraction in pseudophakic eyes.

    Science.gov (United States)

    Khambhiphant, Bharkbhum; Liumsirijarern, Chayata; Saehout, Piyada

    2015-01-01

    This was a prospective descriptive study to determine the changes in intraocular lens (IOL) position after neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser posterior capsulotomy by measuring anterior chamber depth (ACD) and refraction, including the spherical equivalent (SE) and cylinder. Forty-seven pseudophakic eyes with posterior capsule opacification of 29 patients were included. Nd:YAG laser posterior capsulotomy was performed. Patients' ACD and refraction were measured before the treatment, as well as after the treatment at 1 week and 3 months. IOLMaster(®) and an automated refractometer were used at the Department of Ophthalmology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. There were no statistically significant differences in ACD and SE before and after laser treatment at 1 week and 3 months (repeated analysis of variance, P=0.582 and P=0.269, respectively). Both backward IOL movement (number [n]=29) and forward IOL movement (n=18) were found. Some changes in cylindrical refraction were found at 1 week, but decreased at 3 months after capsulotomy (baseline cylinder: -1.16; cylinder at 1 week and 3 months: -1.00 and -1.14, respectively; P=0.012). These changes were the same with one-piece and three-piece IOLs. Nd:YAG laser posterior capsulotomy did not significantly change ACD and SE. It led to cylinder change at 1 week after laser, but the effect decreased at 3 months. This effect was small and may not be clinically significant.

  17. Opacificação tardia de lente intra-ocular de polimetilmetacrilato (PMMA: relato de caso Late opacification of a polymethylmethacrylate (PMMA intraocular lens: case report

    Directory of Open Access Journals (Sweden)

    Otacílio de Oliveira Maia Júnior

    2005-10-01

    Full Text Available O implante das lentes intra-oculares foi grande avanço na reabilitação visual de pacientes submetidos à cirurgia de extração da catarata. Contudo, os materiais utilizados na fabricação destas lentes, apesar de terem boa biocompatibilidade, são passíveis de alterações posteriores ao implante. No presente estudo, os autores relatam um caso raro de opacificação tardia de lente de polimetilmetacrilato, material inerte e bem tolerado intra-ocularmente, discutindo aspectos importantes no manejo desta complicação, bem como indicação de explante e substituição da lente.The use of intraocular lenses was a great advance in visual recovery after cataract surgery. Although usually with good biocompatibility, some alterations in the intraocular lens material may occur after implantation. Polymethylmethacrylate was the first intraocular lens material to be used on a large scale and assumed to be inert and well-tolerated. We present a rare case of late opacification of a polymethylmethacrylate lens, discussing important aspects of its management such as the indication for intraocular lens exchange.

  18. Posterior capsular opacification and intraocular lens decentration. Part I: Comparison of various posterior chamber lens designs implanted in the rabbit model.

    Science.gov (United States)

    Hansen, S O; Solomon, K D; McKnight, G T; Wilbrandt, T H; Gwin, T D; O'Morchoe, D J; Tetz, M R; Apple, D J

    1988-11-01

    Experimental phacoemulsification procedures were performed in 54 Rex rabbits. In 96 eyes, posterior chamber intraocular lenses (IOLs) were implanted in the capsular sac, and 12 eyes served as controls with no lens implantation. The IOLs were divided into eight groups consisting of both one-piece and three-piece styles with various optic designs. Each lens was evaluated for the relative effect on posterior capsular opacification (PCO) and optic decentration, two of the most common complications of modern cataract surgery and IOL implantation. Optics with a convex-anterior, plano-posterior design (the type of IOL optic most frequently implanted today) had the highest incidence of PCO. With capsular fixated IOLs, the features that have a statistically significant impact on reducing PCO include (1) one-piece, all-polymethylmethacrylate (PMMA) IOL styles, (2) a biconvex or posterior convex optic design, and (3) angulated loops. Lens decentration was not affected by the optic design, but statistical analysis showed that one-piece, all-PMMA IOL construction provided the most consistent centration.

  19. Rest and stress transluminal attenuation gradient and contrast opacification difference for detection of hemodynamically significant stenoses in patients with suspected coronary artery disease.

    Science.gov (United States)

    Ko, Brian S; Seneviratne, Sujith; Cameron, James D; Gutman, Sarah; Crossett, Marcus; Munnur, Kiran; Meredith, Ian T; Wong, Dennis T L

    2016-07-01

    This study evaluated the feasibility of stress 320 detector CT coronary angiography (CTA) derived transluminal attenuation gradient (TAG320) and contrast opacification (CO) difference to detect hemodynamically significant stenoses as determined by invasive fractional flow reserve (FFR ≤ 0.80). Twenty-seven patients, including 51 vessels on rest CTA were studied. 16 (31 %) vessels were not interpretable on stress CTA largely secondary to motion artefacts. Receiver operating characteristic curve analysis showed a comparable area under the curve (AUC) for rest and stress TAG320 (0.78 and 0.75) which was higher than CTA alone (0.68), and rest and stress CO difference (0.76 and 0.67). Compared with rest CTA, stress CTA demonstrated inferior image quality (Median Likert score 4 vs. 3, P < 0.0001) and required a higher mean radiation exposure (3.2 vs. 5.1 mSv, P < 0.0001). Stress TAG320 and CO difference is less feasible and was not superior in diagnostic performance when compared with rest TAG320 and CO difference.

  20. Estrategias de prevención de la opacidad de la cápsula posterior Strategies for the prevention of the posterior capsule opacification

    Directory of Open Access Journals (Sweden)

    Iván Hernández López

    2010-01-01

    de la opacidad del saco capsular.The posterior capsule opacification (PCO is the most important aspect in the cataract surgery nowadays. It continues being the more frequent late postoperative complication after cataract surgery associated with decrease of the visual acuity and other visual problems that lead to important social, economical and medical impacts. The laser capsulotomy is an effective procedure for the treatment of this complication but it is far from being the ideal method since it can be associated to considerable complications. This is the reason why several research studies recently have directed their attention to PCO-preventing strategies such as the design of intraocular lenses, modified and/or improved surgical techniques, additional implants, use of cytotoxic agents and drugs as well as new technologies. The gene therapy, among the novel interventions in study, seems to be a promising strategy in this field. Up to the present, there is not a unique method that avoids in a definitive way the development of the capsular opacification. The ophthalmologists should use the combination of all these methods available which have demonstrated a proved effectiveness in the reduction of PCO. Attaining long-term excellent visual result is the main purpose of the modern cataract surgery as well as paving the road towards novel surgical interventions for the treatment of presbyopia in patients older than 40 years. In order to achieve that goal, it is essential to avoid the opacification of the posterior capsule, even more with the use of multifocal and accommodative lenses that are more vulnerable to the opacity than the monofocal lenses. Therefore, we may dare to say that the biggest breakthrough in the modern cataract surgery is still awaiting: the definitive eradication of posterior capsule opacification.

  1. Contrast-enhanced CT of Pulmonary Embolism:Report of 20 cases

    Institute of Scientific and Technical Information of China (English)

    Feng Shiting; Li Ziping; Chen Jingdi; Meng Quanfei; Li Xiangmin; Kuang Jianyi; Zhou Xuhui

    2007-01-01

    Objectives To study the characteristic of pulmonary embolism (PE) in contrast-enhanced CT. Methods The radiological features were described in 20 patients with lobar and proximal PE diagnosed with a Toshiba Xpress/SX CT scanner after contrast material was administrated. Results There were 7 cases of pulmonary embolism (PE) secondary to lower limb deep vein thrombosis (DVT), of which 2 cases were related to sauna bath. We grouped the cases according to their extensiveness of embolism: mild, moderate, severe, or complete embolism. Mild embolism: the emboli occupied less than 30%, of the inner diameter of pulmonary artery (PA). Median embolism: the emboli occupied 30~50% of the PA diameter. Severe embolism: the emboli occupied over half of the PA (50%), but there were contrast flow. Completed embolism: there was no contrast found around the emboli. The direct sign of PE was a filling defect or no opacification in the affected branch of pulmonary artery (PA). There were 9 other secondary signs: ①widen PA, ②enlarged right ventricle and the right atrium, ③increased translucency of the lung and decreased bronchovascular shadows, ④shrunken pulmonary veins liked dried rattan, ⑤decreased left atrium and the left ventricle size, ⑥shifting of interventricular septum to the left and posterior direction,⑦The lateral lung parenchyma demonstrated in a triangular shape,⑧pleural effusion and ⑨pericardiacle effusion. Conclusions The diagnosis of PE was revealed by 10 radiological signs by contrast-enhanced CT:With full understanding of the pathophysiological basis of these 10 signs:correct diagnosis of pulmonary embolism can be made. PE is commonly caused by lower limb. And sauna bath is one of the main predisposing causes.

  2. Optimal probabilistic dense coding schemes

    Science.gov (United States)

    Kögler, Roger A.; Neves, Leonardo

    2017-04-01

    Dense coding with non-maximally entangled states has been investigated in many different scenarios. We revisit this problem for protocols adopting the standard encoding scheme. In this case, the set of possible classical messages cannot be perfectly distinguished due to the non-orthogonality of the quantum states carrying them. So far, the decoding process has been approached in two ways: (i) The message is always inferred, but with an associated (minimum) error; (ii) the message is inferred without error, but only sometimes; in case of failure, nothing else is done. Here, we generalize on these approaches and propose novel optimal probabilistic decoding schemes. The first uses quantum-state separation to increase the distinguishability of the messages with an optimal success probability. This scheme is shown to include (i) and (ii) as special cases and continuously interpolate between them, which enables the decoder to trade-off between the level of confidence desired to identify the received messages and the success probability for doing so. The second scheme, called multistage decoding, applies only for qudits ( d-level quantum systems with d>2) and consists of further attempts in the state identification process in case of failure in the first one. We show that this scheme is advantageous over (ii) as it increases the mutual information between the sender and receiver.

  3. STAR FORMATION IN DENSE CLUSTERS

    Energy Technology Data Exchange (ETDEWEB)

    Myers, Philip C., E-mail: pmyers@cfa.harvard.edu [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States)

    2011-12-10

    A model of core-clump accretion with equally likely stopping describes star formation in the dense parts of clusters, where models of isolated collapsing cores may not apply. Each core accretes at a constant rate onto its protostar, while the surrounding clump gas accretes as a power of protostar mass. Short accretion flows resemble Shu accretion and make low-mass stars. Long flows resemble reduced Bondi accretion and make massive stars. Accretion stops due to environmental processes of dynamical ejection, gravitational competition, and gas dispersal by stellar feedback, independent of initial core structure. The model matches the field star initial mass function (IMF) from 0.01 to more than 10 solar masses. The core accretion rate and the mean accretion duration set the peak of the IMF, independent of the local Jeans mass. Massive protostars require the longest accretion durations, up to 0.5 Myr. The maximum protostar luminosity in a cluster indicates the mass and age of its oldest protostar. The distribution of protostar luminosities matches those in active star-forming regions if protostars have a constant birthrate but not if their births are coeval. For constant birthrate, the ratio of young stellar objects to protostars indicates the star-forming age of a cluster, typically {approx}1 Myr. The protostar accretion luminosity is typically less than its steady spherical value by a factor of {approx}2, consistent with models of episodic disk accretion.

  4. Star formation in dense clusters

    CERN Document Server

    Myers, Philip C

    2011-01-01

    A model of core-clump accretion with equally likely stopping describes star formation in the dense parts of clusters, where models of isolated collapsing cores may not apply. Each core accretes at a constant rate onto its protostar, while the surrounding clump gas accretes as a power of protostar mass. Short accretion flows resemble Shu accretion, and make low-mass stars. Long flows resemble reduced Bondi accretion and make massive stars. Accretion stops due to environmental processes of dynamical ejection, gravitational competition, and gas dispersal by stellar feedback, independent of initial core structure. The model matches the field star IMF from 0.01 to more than 10 solar masses. The core accretion rate and the mean accretion duration set the peak of the IMF, independent of the local Jeans mass. Massive protostars require the longest accretion durations, up to 0.5 Myr. The maximum protostar luminosity in a cluster indicates the mass and age of its oldest protostar. The distribution of protostar luminosi...

  5. Chronic hypersensitivity pneumonitis: high resolution computed tomography patterns and pulmonary function indices as prognostic determinants

    Energy Technology Data Exchange (ETDEWEB)

    Walsh, Simon L.F.; Devaraj, Anand; Hansell, David M. [Royal Brompton Hospital, Department of Radiology, London (United Kingdom); Sverzellati, Nicola [University of Parma, Department of Clinical Sciences, Section of Radiology, Parma (Italy); Wells, Athol U. [Royal Brompton Hospital, Interstitial Lung Diseases Unit, London (United Kingdom)

    2012-08-15

    To investigate high resolution computed tomography (HRCT) and pulmonary function indices (PFTs) for determining prognosis in patients with chronic fibrotic hypersensitivity pneumonitis (CHP). Case records, PFTs (FEV{sub 1}, FVC and DLco) and HRCTs of ninety-two patients with chronic hypersensitivity pneumonitis were evaluated. HRCT studies were scored by two observers for total disease extent, ground-glass opacification, fine and coarse reticulation, microcystic and macrocystic honeycombing, centrilobular emphysema and consolidation. Traction bronchiectasis within each pattern was graded. Using Cox proportional hazards regression models the prognostic strength of individual HRCT patterns and pulmonary function test variables were determined. There were forty two deaths during the study period. Increasing severity of traction bronchiectasis was the strongest predictor of mortality (HR 1.10, P < 0.001, 95%CI 1.04-1.16). Increasing global interstitial disease extent (HR 1.02, P = 0.02, 95%CI 1.00-1.03), microcystic honeycombing (HR 1.09, P = 0.019, 95%CI 1.01-1.17) and macrocystic honeycombing (HR 1.06, P < 0.01, 95%CI 1.01-1.10) were also independent predictors of mortality. In contrast, no individual PFT variable was predictive of mortality once HRCT patterns were accounted for. HRCT patterns, in particular, severity of traction bronchiectasis and extent of honeycombing are superior to pulmonary function tests for predicting mortality in patients with CHP. (orig.)

  6. Thermophysical properties of warm dense hydrogen

    CERN Document Server

    Holst, Bastian; Desjarlais, Michael P

    2007-01-01

    We study the thermophysical properties of warm dense hydrogen using quantum molecular dynamics simulations. New results are presented for the pair distribution functions, the equation of state, the Hugoniot curve, and the reflectivity. We compare with available experimental data and predictions of the chemical picture. Especially, we discuss the nonmetal-to-metal transition which occurs at about 40 GPa in the dense fluid.

  7. Heavy meson production in hot dense matter

    NARCIS (Netherlands)

    Tolos, Laura; Gamermann, Daniel; Garcia-Recio, Carmen; Molina, Raquel; Nieves, Juan; Oset, Eulogio; Ramos, Angels; Nieves, JM; Oset, E; Vacas, MJV

    2010-01-01

    The properties of charmed mesons in dense matter are studied using a unitary coupled-channel approach in the nuclear medium which takes into account Pauli-blocking effects and meson self-energies in a self-consistent manner. We obtain the open-charm meson spectral functions in this dense nuclear env

  8. Finding dense locations in indoor tracking data

    DEFF Research Database (Denmark)

    Ahmed, Tanvir; Pedersen, Torben Bach; Lu, Hua

    2014-01-01

    Finding the dense locations in large indoor spaces is very useful for getting overloaded locations, security, crowd management, indoor navigation, and guidance. Indoor tracking data can be very large and are not readily available for finding dense locations. This paper presents a graph-based mode...

  9. Giant infantile pulmonary hemangioma

    Energy Technology Data Exchange (ETDEWEB)

    Pandya, Rajul; Tummala, Venkat [Hurley Medical Center One Hurley Plaza, Department of Radiology, Flint, MI (United States)

    2010-12-15

    We present a very unusual case of giant infantile pulmonary hemangioma presenting as a large solitary pulmonary mass. This was successfully managed with surgical resection. Histological examination revealed that the mass was positive for GLUT-1 receptor, a marker for infantile hemangioma. To our knowledge only a few cases of pulmonary hemangioma have been described previously in the literature. Pulmonary hemangiomas are very rare lesions, most of them presenting as a pulmonary mass. This case emphasizes the fact that this rare lesion should be considered in the differential of an enhancing pulmonary mass in an infant. (orig.)

  10. Dense image correspondences for computer vision

    CERN Document Server

    Liu, Ce

    2016-01-01

    This book describes the fundamental building-block of many new computer vision systems: dense and robust correspondence estimation. Dense correspondence estimation techniques are now successfully being used to solve a wide range of computer vision problems, very different from the traditional applications such techniques were originally developed to solve. This book introduces the techniques used for establishing correspondences between challenging image pairs, the novel features used to make these techniques robust, and the many problems dense correspondences are now being used to solve. The book provides information to anyone attempting to utilize dense correspondences in order to solve new or existing computer vision problems. The editors describe how to solve many computer vision problems by using dense correspondence estimation. Finally, it surveys resources, code, and data necessary for expediting the development of effective correspondence-based computer vision systems.   ·         Provides i...

  11. Pulmonary high-resolution computed tomography findings in nephropathia epidemica

    Energy Technology Data Exchange (ETDEWEB)

    Paakkala, Antti, E-mail: antti.paakkala@pshp.fi [Medical Imaging Centre, Tampere University Hospital, 33521 Tampere (Finland); Jaervenpaeae, Ritva, E-mail: ritva.jarvenpaa@pshp.fi [Medical Imaging Centre, Tampere University Hospital, 33521 Tampere (Finland); Maekelae, Satu, E-mail: satu.marjo.makela@uta.fi [Department of Internal Medicine, Tampere University Hospital, 33521 Tampere (Finland); Medical School, University of Tampere, 33521 Tampere (Finland); Huhtala, Heini, E-mail: heini.huhtala@uta.fi [School of Public Health, University of Tampere, 33521 Tampere (Finland); Mustonen, Jukka, E-mail: jukka.mustonen@uta.fi [Department of Internal Medicine, Tampere University Hospital, 33521 Tampere (Finland); Medical School, University of Tampere, 33521 Tampere (Finland)

    2012-08-15

    Purpose: To evaluate lung high-resolution computed tomography (HRCT) findings in patients with Puumala hantavirus-induced nephropathia epidemica (NE), and to determine if these findings correspond to chest radiograph findings. Materials and methods: HRCT findings and clinical course were studied in 13 hospital-treated NE patients. Chest radiograph findings were studied in 12 of them. Results: Twelve patients (92%) showed lung parenchymal abnormalities in HRCT, while only 8 had changes in their chest radiography. Atelectasis, pleural effusion, intralobular and interlobular septal thickening were the most common HRCT findings. Ground-glass opacification (GGO) was seen in 4 and hilar and mediastinal lymphadenopathy in 3 patients. Atelectasis and pleural effusion were also mostly seen in chest radiographs, other findings only in HRCT. Conclusion: Almost every NE patient showed lung parenchymal abnormalities in HRCT. The most common findings of lung involvement in NE can be defined as accumulation of pleural fluid and atelectasis and intralobular and interlobular septal thickening, most profusely in the lower parts of the lung. As a novel finding, lymphadenopathy was seen in a minority, probably related to capillary leakage and overall fluid overload. Pleural effusion is not the prominent feature in other viral pneumonias, whereas intralobular and interlobular septal thickening are characteristic of other viral pulmonary infections as well. Lung parenchymal findings in HRCT can thus be taken not to be disease-specific in NE and HRCT is useful only for scientific purposes.

  12. Thin-section Computed Tomography Detects Long-term Pulmonary Sequelae 3 Years after Novel Influenza A Virus-associated Pneumonia

    Institute of Scientific and Technical Information of China (English)

    Zhi-Heng Xing; Xin Sun; Long Xu; Qi Wu; Li Li; Xian-Jie Wu; Xu-Guang Shao

    2015-01-01

    Background:The aim of this research was to evaluate long-term pulmonary sequelae on paired inspiration-expiration thin-section computed tomography (CT) scans 3 years after influenza A (H 1N 1) virus-associated pneumonia,and to analyze the affecting factors on pulmonary fibrosis.Methods:Twenty-four patients hospitalized with H 1N 1 virus-associated pneumonia at our hospital between September 2009 and January 2010 were included.The patients underwent thin-section CT 3 years after recovery.Abnormal pulmonary lesion patterns (ground-glass opacity,consolidation,parenchymal bands,air trapping,and reticulation) and evidence of fibrosis (architectural distortion,traction bronchiectasis,or honeycombing) were evaluated on follow-up thin-section CT.Patients were assigned to Group 1 (with CT evidence of fibrosis) and Group 2 (without CT evidence of fibrosis).Demographics,rate of mechanical ventilation therapy,rate of intensive care unit admission,cumulative prednisolone-equivalent dose,laboratory tests results (maximum levels of alanine aminotransferase,aspartate transaminase [AST],lactate dehydrogenase [LDH],and creatine kinase [CK]),and peak radiographic opacification of 24 patients during the course of their illness in the hospital were compared between two groups.Results:Parenchymal abnormality was present in 17 of 24 (70.8%) patients and fibrosis occurred in 10 of 24 (41.7%) patients.Patients in Group 1 (10/24; 41.7%) had a higher rate of mechanical ventilation therapy (Z =-2.340,P =0.019),higher number of doses of cumulative prednisolone-equivalent (Z =-2.579,P =0.010),higher maximum level of laboratory tests results (AST [Z =-2.140,P =0.032],LDH [Z=-3.227,P =0.001],and CK [Z=-3.345,P =0.019]),and higher peak opacification on chest radiographs (Z=-2.743,P =0.006) than patients in group 2 (14/24; 58.3%).Conclusions:H1N1 virus-associated pneumonia frequently is followed by long-term pulmonary sequelae,including fibrotic changes,in lung parenchyma.Patients who need

  13. Thin-section Computed Tomography Detects Long-term Pulmonary Sequelae 3 Years after Novel Influenza A Virus-associated Pneumonia

    Directory of Open Access Journals (Sweden)

    Zhi-Heng Xing

    2015-01-01

    Full Text Available Background: The aim of this research was to evaluate long-term pulmonary sequelae on paired inspiration-expiration thin-section computed tomography (CT scans 3 years after influenza A (H1N1 virus-associated pneumonia, and to analyze the affecting factors on pulmonary fibrosis. Methods: Twenty-four patients hospitalized with H1N1 virus-associated pneumonia at our hospital between September 2009 and January 2010 were included. The patients underwent thin-section CT 3 years after recovery. Abnormal pulmonary lesion patterns (ground-glass opacity, consolidation, parenchymal bands, air trapping, and reticulation and evidence of fibrosis (architectural distortion, traction bronchiectasis, or honeycombing were evaluated on follow-up thin-section CT. Patients were assigned to Group 1 (with CT evidence of fibrosis and Group 2 (without CT evidence of fibrosis. Demographics, rate of mechanical ventilation therapy, rate of intensive care unit admission, cumulative prednisolone-equivalent dose, laboratory tests results (maximum levels of alanine aminotransferase, aspartate transaminase [AST], lactate dehydrogenase [LDH], and creatine kinase [CK], and peak radiographic opacification of 24 patients during the course of their illness in the hospital were compared between two groups. Results: Parenchymal abnormality was present in 17 of 24 (70.8% patients and fibrosis occurred in 10 of 24 (41.7% patients. Patients in Group 1 (10/24; 41.7% had a higher rate of mechanical ventilation therapy (Z = −2.340, P = 0.019, higher number of doses of cumulative prednisolone-equivalent (Z = −2.579, P = 0.010, higher maximum level of laboratory tests results (AST [Z = −2.140, P = 0.032], LDH [Z = −3.227, P = 0.001], and CK [Z = −3.345, P = 0.019], and higher peak opacification on chest radiographs (Z = −2.743, P = 0.006 than patients in group 2 (14/24; 58.3%. Conclusions: H1N1 virus-associated pneumonia frequently is followed by long-term pulmonary sequelae

  14. Pulmonary Hemorrhage in Cryoglobulinemia

    Directory of Open Access Journals (Sweden)

    G Kirkpatrick

    2015-01-01

    Full Text Available Pulmonary manifestations of cryoglobulinemia are uncommon and their clinical behaviour is unpredictable, ranging from mild dyspnea to life-threatening presentations. A patient with cryoglobulinemia who presented with hypoxic respiratory failure attributed to pulmonary hemorrhage is reported.

  15. Pregnancy and pulmonary hypertension

    NARCIS (Netherlands)

    Pieper, Petronella G.; Lameijer, Heleen; Hoendermis, Elke S.

    Pulmonary hypertension during pregnancy is associated with considerable risks of maternal mortality and morbidity. Our systematic review of the literature on the use of targeted treatments for pulmonary arterial hypertension during pregnancy indicates a considerable decrease of mortality since a

  16. HIV and Pulmonary Hypertension

    Science.gov (United States)

    ... 03-13T18:29:11+00:00 PH and HIV Print PH and HIV Brochure (PDF) Order Copies ... to know about pulmonary hypertension in connection with HIV? Although pulmonary hypertension and HIV are two separate ...

  17. Miliary pulmonary cryptococcosis

    Directory of Open Access Journals (Sweden)

    Shane Kelly

    2014-10-01

    Imaging features of pulmonary cryptococcosis are generally of well-defined pleural-based nodules and less commonly alveolar infiltrates, lymphadenopathy, pleural effusions or cavitating lesions. Miliary pulmonary infiltrates are an exceptionally rare presentation.

  18. Pulmonary arteriovenous fistula

    Science.gov (United States)

    ... medlineplus.gov/ency/article/001090.htm Pulmonary arteriovenous fistula To use the sharing features on this page, please enable JavaScript. Pulmonary arteriovenous fistula is an abnormal connection between an artery and ...

  19. Histoplasmosis - acute (primary) pulmonary

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000098.htm Histoplasmosis - acute (primary) pulmonary To use the sharing features on this page, please enable JavaScript. Acute pulmonary histoplasmosis is a respiratory infection that is caused by ...

  20. Expression of Livin in animal model of posterior capsule opacification%Livin 在后发性白内障动物模型中的表达

    Institute of Scientific and Technical Information of China (English)

    刘淑君; 赵桂秋; 李元彬; 蔄雪静; 王文亭; 张振华

    2013-01-01

    AIM: To establish animal models of posterior capsule opacification ( PCO ) in New Zealand white rabbits and detect the expression of the Livin in PCO tissue. METHODS:Thirty healthy adult New Zealand white rabbits were randomly divided into experimental group and control group.Ultrasonic phacoemulsifications were performed in the 25 experiment rabbits under intramuscular injection anesthesia.The rabbits'eyes were examined by slit lamp microscope to observe the development of PCO after surgery and at 3d, 7d, 14d and 28d.The 5 rabbits in control group were executed to take the posterior capsule of right eyes.Reverse transcription polymerase ( RT -PCR ) and western -blotting were performed to detect the expression of Livin in PCO at different time points postoperatively. RESULTS:Both RT-PCR and western-blotting method indicated that different levels of expression of Livin could be detected in the tissue of PCO in group B, C, D, E except control group and group A that instantly after surgery.The two methods indicated that Livin reached the peak in group C and decreased in group D, lower in group E and in group B reached the bottom. CONCLUSION:The expression of Livin can be detected in the tissue of PCO in a certain similar time.The study indicated that Livin correlates with the pathogenesis of PCO.It may provide a novel tool for the investigation of gene therapy for PCO.%目的:建立新西兰大白兔后发性白内障( posterior capsule opacification ,PCO)动物模型,检测凋亡抑制因子Livin在PCO中的表达,从而探讨 Livin 在 PCO 形成过程中的作用。  方法:选用健康新西兰大白兔30只,随机分为实验组(25只),分为A,B,C,D,E组,对照组(5只),实验组行右眼晶状体皮质吸出,分别于术后即刻;3,7,14,28 d (每个时间点5只)对术眼行裂隙灯显微镜检查,并处死动物获取术眼晶状体后囊膜,对照组直接处死动物获取右眼后囊膜,采用

  1. Effect of femtosecond laser-assisted lens surgery on posterior capsule opacification in the human capsular bag in vitro.

    Science.gov (United States)

    Wertheimer, Christian; Kreutzer, Thomas C; Dirisamer, Martin; Eibl-Lindner, Kirsten; Kook, Daniel; Priglinger, Siegfried; Mayer, Wolfgang J

    2017-03-01

    To compare posterior capsule opacification (PCO) by observing lens epithelial cell growth in the human capsular bag in vitro between conventional lens surgery using phacoemulsification (Phaco) technique and femtosecond laser-assisted lens surgery (FLACS). For the in vitro human capsular bag model, 18 cadaver eyes from nine human donors underwent three types of lens surgery. Three groups consisting of six capsular bags were established, that is FLACS, Phaco and extracapsular lens extraction (ECCE). The capsular bag was transferred into equal cell culture conditions after using one of the defined surgical approaches. Cellular growth of lens epithelial cells was observed and photo-documented. The time until full cell-coverage of the capsular bag was measured. The human capsular bag model can be successfully prepared using FLACS. There was no statistically significant difference in time until cell-coverage of the human donor capsular bag in vitro in all three surgical settings (ECCE versus Phaco p = 0.6; ECCE versus FLACS p = 1.0; Phaco versus FLACS p = 1.0). In our in vitro human capsular bag model, we could not observe a statistically significant difference in PCO formation using different surgical approaches of lens extraction. Therefore, PCO formation might not be attributed to the type of surgery. Furthermore, this study shows that FLACS can be used for the human capsular bag model preparation and validates the human capsular bag model for future research. © 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

  2. Clinical analysis of anterior capsular opacification after phacoemulsification%超声乳化术后晶状体前囊膜混浊临床分析

    Institute of Scientific and Technical Information of China (English)

    古学军; 张旭; 喻理; 孙涛; 余学清; 程先华; 黄传华; 易敬林

    2015-01-01

    目的 探讨白内障超声乳化术后前囊膜混浊(anterior capsular opacification,ACO)的临床表现、发病危险因素和影响因素,为预防术后ACO提供可靠有效的依据.方法 采用回顾性分析研究.对2012年3月至2013年12月在南昌大学附属眼科医院施行白内障超声乳化联合人工晶状体植入术1 056例(1 325只眼),术后1周、1、3和6个月复查,观察前囊膜混浊情况、前囊口收缩程度和IOL位置等.结果 术后共发生213例(225只眼)ACO,其中162例(170只眼)为1级ACO,39例(42只眼)为2级ACO,9例(9只眼)为3级ACO,3例(4只眼)为4级ACO.发生时间≤3个月占83.1%,撕囊口直径过小占61.3%,未进行前囊膜抛光占84.0%,植入亲水性丙烯酸酯IOL占75.1%,合并眼部和全身疾病占54.2%,术后有明显眼前节反应58.2%,严重ACO可出现远视漂移、视力下降等.结论 超声乳化术撕囊口直径过小、晶状体上皮细胞残留是ACO发生的根本原因,合并眼部和全身疾病患者谨慎植入亲水性丙烯酸酯IOL,术后眼前节反应较重者应警惕发生ACO.%Objective To investigate anterior capsule opacification (ACO) factors and their clinical manifestation,risk factors and influence after phacoemulsification,in order to provide a reliable basis for the prevention of post operative ACO.Methods Retrospective analysis of hospital operative records was analyzed from March 2012 to December 2013.During this time period,1056 cases (1325 eyes) of phacoemulsification and intraocular lens implantation (IOL) were performed.Anterior capsule opacification were observed and analyzed 1 week,1 month,3 months and 6 months postoperatively,and degree of anterior capsular contraction and IOL location were reviewed.Results Of 213 cases (225 eyes) with postoperative ACO,162 cases (170 eyes) were of grade 1,39 cases (42 eyes) grade 2,9 cases (9 eyes) grade 3,3 cases (4 eyes) grade 4.Cases with manifestation time less than three months accounted for 83.1

  3. Illness experiences of persons with chronic obstructive pulmonary disease: self-perceived efficacy of home-based pulmonary rehabilitation

    Directory of Open Access Journals (Sweden)

    Juliana Maria de Sousa Pinto

    2014-06-01

    Full Text Available This qualitative study explores the illness experiences, the efficacy of pulmonary rehabilitation as perceived by patients with chronic obstructive pulmonary disease (COPD and their rationale for improvements in health. 23 patients participated in a daily, three-month home-based pulmonary rehabilitation. A pre-post self-perceived assessment of efficacy was conducted. Semi-structured interviews, illness narratives and participant-observation provided a “dense description” of patients' lived-experience before and after the program. Interviews and narratives were tape-recorded, transcribed and coded. Qualitative data was subjected to “thematic content analysis” and “contextualized semantic interpretation”. Patients compare functional status before and after falling ill, experience loss, stigma and depression, describe health improvements and judge the pulmonary rehabilitation’s efficacy. Giving voice to chronically-ill patients, as individuals, is needed. To reduce clinical conflicts, health professionals should encourage illness narratives and value their patients’ lived-experience.

  4. Illness experiences of persons with chronic obstructive pulmonary disease: self-perceived efficacy of home-based pulmonary rehabilitation.

    Science.gov (United States)

    Pinto, Juliana Maria de Sousa; Martín-Nogueras, Ana; Nations, Marilyn

    2014-06-01

    This qualitative study explores the illness experiences, the efficacy of pulmonary rehabilitation as perceived by patients with chronic obstructive pulmonary disease (COPD) and their rationale for improvements in health. 23 patients participated in a daily, three-month home-based pulmonary rehabilitation. A pre-post self-perceived assessment of efficacy was conducted. Semi-structured interviews, illness narratives and participant-observation provided a "dense description" of patients' lived-experience before and after the program. Interviews and narratives were tape-recorded, transcribed and coded. Qualitative data was subjected to "thematic content analysis" and "contextualized semantic interpretation". Patients compare functional status before and after falling ill, experience loss, stigma and depression, describe health improvements and judge the pulmonary rehabilitation's efficacy. Giving voice to chronically-ill patients, as individuals, is needed. To reduce clinical conflicts, health professionals should encourage illness narratives and value their patients' lived-experience.

  5. Pulmonary Hypertension Overview

    Science.gov (United States)

    ... chest X-ray, a breathing test called a pulmonary function test and an echocardiogram (sometimes called an “echo”). Your doctor may also need to do other tests to find out whether another medical condition is causing your pulmonary hypertension. TreatmentHow is pulmonary hypertension treated?If the ...

  6. Pulmonary Hypertension Association

    Science.gov (United States)

    ... at www.AHeartCures.org . Help Kickoff November’s Pulmonary Hypertension Awareness Month Want to help raise awareness for ... Heart2CurePH | Help promote Awareness Month Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Awareness Chronic thromboembolic pulmonary hypertension (CTEPH) is ...

  7. Pulmonary embolism during pregnancy: diagnosis with lung scintigraphy or CT angiography?

    Science.gov (United States)

    Revel, Marie-Pierre; Cohen, Stéphanie; Sanchez, Olivier; Collignon, Marie-Anne; Thiam, Rokhaya; Redheuil, Alban; Meyer, Guy; Frija, Guy

    2011-02-01

    To evaluate the rate of positive, negative, and indeterminate results and the agreement between initial and expert readings for lung scintigraphy and computed tomographic (CT) angiography performed in patients suspected of having pulmonary embolism (PE) during pregnancy. Institutional review board approval was obtained. The authors retrospectively analyzed the images from lung scintigraphy and CT angiography performed in pregnant patients during the past 9 years. Images from 46 CT angiographic examinations performed in 43 patients and 91 of 94 lung scintigraphic examinations were reviewed by experts, whose readings were then compared with the initial reports. For CT angiography, the quality of opacification was graded as good, suboptimal, or poor and intraarterial attenuation was measured. The rates of positive findings (seven of 43 patients [16%] with CT angiography and 10 of 91 patients [11%] with scintigraphy, P = .36), negative findings (28 of 43 patients [65%] with CT angiography and 64 of 91 patients [70%] with scintigraphy, P = .54), and indeterminate findings (eight of 43 patients [19%] with CT angiography and 17 of 91 patients [19%] with scintigraphy, P = .99) were similar for CT angiography and lung scintigraphy. There were four discrepancies between initial and expert readings for CT angiography (κ = 0.84; confidence interval: 0.68, 0.99) and 14 for lung scintigraphy (κ = 0.75; 95% confidence interval: 0.63, 0.87). Opacification was classified as good for only 23 of the 46 CT angiographic examinations (50%). Attenuation values were significantly different among the groups with good, suboptimal, or poor opacification. Alternative diagnoses unsuspected at chest radiography were demonstrated at CT angiography in five of the 43 patients (12%). The mean maternal radiation dose was 0.9 mSv for lung scintigraphy and 7.3 mSv for CT angiography. Lung scintigraphy and CT angiography have comparable performances for PE diagnosis during pregnancy. Interobserver

  8. Kinetic chemistry of dense interstellar clouds

    Energy Technology Data Exchange (ETDEWEB)

    Graedel, T.E.; Langer, W.D.; Frerking, M.A.

    1982-03-01

    A detailed model of the time-dependent chemistry of dense interstellar clouds has been developed to study the dominant chemical processes in carbon and oxygen isotope fractionation, formation of nitrogen-containing molecules, evolution of product molecules as a function of cloud density and temperature, and other topics of interest. The full computation involves 328 individual reactions (expanded to 1067 to study carbon and oxygen isotope chemistry); photodegradation processes are unimportant in these dense clouds and are excluded.

  9. Multidetector computed tomography pulmonary angiography in childhood acute pulmonary embolism

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Chun Xiang; Zhang, Long Jiang; Lu, Guang Ming [Medical School of Nanjing University, Department of Medical Imaging, Jinling Hospital, Nanjing, Jiangsu (China); Schoepf, U.J. [Medical School of Nanjing University, Department of Medical Imaging, Jinling Hospital, Nanjing, Jiangsu (China); Medical University of South Carolina, Department of Radiology and Radiological Science, Charleston, SC (United States); Medical University of South Carolina, Department of Pediatrics, Charleston, SC (United States); Chowdhury, Shahryar M. [Medical University of South Carolina, Department of Pediatrics, Charleston, SC (United States); Fox, Mary A. [Medical University of South Carolina, Department of Radiology and Radiological Science, Charleston, SC (United States)

    2015-09-15

    Pulmonary embolism is a life-threatening condition affecting people of all ages. Multidetector row CT pulmonary angiography has improved the imaging of pulmonary embolism in both adults and children and is now regarded as the routine modality for detection of pulmonary embolism. Advanced CT pulmonary angiography techniques developed in recent years, such as dual-energy CT, have been applied as a one-stop modality for pulmonary embolism diagnosis in children, as they can simultaneously provide anatomical and functional information. We discuss CT pulmonary angiography techniques, common and uncommon findings of pulmonary embolism in both conventional and dual-energy CT pulmonary angiography, and radiation dose considerations. (orig.)

  10. Mechanisms responsible for pulmonary hypertension

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ Pulmonary hypertension is a pathophysiologic process characterized by progressive elevation of pulmonary vascular resistance and right heart failure, which is a common complication of many diseases. Pulmonary hypertension with no apparent causes (unknown etiology) is termed primary pulmonary hypertension or, more recently, idiopathic pulmonary arterial hypertension (IPAH).

  11. Pulmonary arterial hypertension : an update

    NARCIS (Netherlands)

    Hoendermis, E. S.

    2011-01-01

    Pulmonary arterial hypertension (PAH), defined as group 1 of the World Heart Organisation (WHO) classification of pulmonary hypertension, is an uncommon disorder of the pulmonary vascular system. It is characterised by an increased pulmonary artery pressure, increased pulmonary vascular resistance a

  12. Handbook of pulmonary emergencies

    Energy Technology Data Exchange (ETDEWEB)

    Spaquolo, S.V.; Medinger, A

    1986-01-01

    This book presents information on the following topics: clinical assessment of the patient with pulmonary disease; interpretation of arterial blood gases in the emergency patient; life-threatening pneumonia; extrapulmonic ventilatory failure; acute inhalation lung disease; pulmonary edema; near drowning; chest trauma; upper airway emergencies; chronic lung disease with acute respiratory decompensation; acute respiratory failure in the patient with chronic airflow obstruction; asthma; hemoptysis; embolic pulmonary disease; superior vena cava syndrome; catastrophic pleural disease; ventilatory assistance and its complications; and ventilator emergencies.

  13. Injection of photoelectrons into dense argon gas

    CERN Document Server

    Borghesani, A F

    2010-01-01

    The injection of photoelectrons in a gaseous or liquid sample is a widespread technique to produce a cold plasma in a weakly--ionized system in order to study the transport properties of electrons in a dense gas or liquid. We report here the experimental results of photoelectron injection into dense argon gas at the temperatureT=142.6 K as a function of the externally applied electric field and gas density. We show that the experimental data can be interpreted in terms of the so called Young-Bradbury model only if multiple scattering effects due to the dense environment are taken into account when computing the scattering properties and the energetics of the electrons.

  14. Miliary pulmonary cryptococcosis

    Science.gov (United States)

    Kelly, Shane; Marriott, Deborah

    2014-01-01

    A 32-year-old HIV positive male presents with fevers and a non-productive cough. Initial X-ray and subsequent computerised tomography of the chest shows a bilateral miliary pattern of pulmonary infiltration highly suggestive of disseminated tuberculosis. However subsequent results were consistent with disseminated cryptococcosis, including pulmonary involvement, with cryptococcus identified on transbronchial tissue biopsy, and on blood and cerebrospinal fluid cultures. Imaging features of pulmonary cryptococcosis are generally of well-defined pleural-based nodules and less commonly alveolar infiltrates, lymphadenopathy, pleural effusions or cavitating lesions. Miliary pulmonary infiltrates are an exceptionally rare presentation. PMID:25379393

  15. Idiopathic pulmonary artery aneurysm.

    Science.gov (United States)

    Kotwica, Tomasz; Szumarska, Joanna; Staniszewska-Marszalek, Edyta; Mazurek, Walentyna; Kosmala, Wojciech

    2009-05-01

    Pulmonary artery aneurysm (PAA) is an uncommon lesion, which may be associated with different etiologies including congenital cardiovascular diseases, systemic vasculitis, connective tissue diseases, infections, and trauma. Idiopathic PAA is sporadically diagnosed by exclusion of concomitant major pathology. We report a case of a 56-year-old female with an idiopathic pulmonary artery dilatation identified fortuitously by echocardiography and confirmed by contrast-enhanced computed tomography. Neither significant pulmonary valve dysfunction nor pulmonary hypertension and other cardiac abnormalities which might contribute to the PAA development were found. Here, we describe echocardiographic and computed tomography findings and review the literature on PAA management.

  16. Regulation of pulmonary inflammation by mesenchymal cells

    NARCIS (Netherlands)

    Alkhouri, Hatem; Poppinga, Wilfred Jelco; Tania, Navessa Padma; Ammit, Alaina; Schuliga, Michael

    2014-01-01

    Pulmonary inflammation and tissue remodelling are common elements of chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and pulmonary hypertension (PH). In disease, pulmonary mesenchymal cells not only contribute to tissue

  17. Pulmonary arterial hypertension in pregnancy.

    Science.gov (United States)

    Običan, Sarah G; Cleary, Kirsten L

    2014-08-01

    Pulmonary hypertension is a medical condition characterized by elevated pulmonary arterial pressure and secondary right heart failure. Pulmonary arterial hypertension is a subset of pulmonary hypertension, which is characterized by an underlying disorder of the pulmonary arterial vasculature. Pulmonary hypertension can also occur secondarily to structural cardiac disease, autoimmune disorders, and toxic exposures. Although pregnancies affected by pulmonary hypertension and pulmonary arterial hypertension are rare, the pathophysiology exacerbated by pregnancy confers both high maternal and fetal mortality and morbidity. In light of new treatment modalities and the use of a multidisciplinary approach to care, maternal outcomes may be improving.

  18. DNS of turbulent flows of dense gases

    Science.gov (United States)

    Sciacovelli, L.; Cinnella, P.; Gloerfelt, X.; Grasso, F.

    2017-03-01

    The influence of dense gas effects on compressible turbulence is investigated by means of numerical simulations of the decay of compressible homogeneous isotropic turbulence (CHIT) and of supersonic turbulent flows through a plane channel (TCF). For both configurations, a parametric study on the Mach and Reynolds numbers is carried out. The dense gas considered in these parametric studies is PP11, a heavy fluorocarbon. The results are systematically compared to those obtained for a diatomic perfect gas (air). In our computations, the thermodynamic behaviour of the dense gases is modelled by means of the Martin-Hou equation of state. For CHIT cases, initial turbulent Mach numbers up to 1 are analyzed using mesh resolutions up to 5123. For TCF, bulk Mach numbers up to 3 and bulk Reynolds numbers up to 12000 are investigated. Average profiles of the thermodynamic quantities exhibit significant differences with respect to perfect-gas solutions for both of the configurations. For high-Mach CHIT, compressible structures are modified with respect to air, with weaker eddy shocklets and stronger expansions. In TCF, the velocity profiles of dense gas flows are much less sensitive to the Mach number and collapse reasonably well in the logarithmic region without any special need for compressible scalings, unlike the case of air, and the overall flow behaviour is midway between that of a variable-property liquid and that of a gas.

  19. Dense matter at RAON: Challenges and possibilities

    Science.gov (United States)

    Lee, Yujeong; Lee, Chang-Hwan; Gaitanos, T.; Kim, Youngman

    2016-11-01

    Dense nuclear matter is ubiquitous in modern nuclear physics because it is related to many interesting microscopic and macroscopic phenomena such as heavy ion collisions, nuclear structure, and neutron stars. The on-going rare isotope science project in Korea will build up a rare isotope accelerator complex called RAON. One of the main goals of RAON is to investigate rare isotope physics including dense nuclear matter. Using the relativistic Boltzmann-Uehling-Uhlenbeck (RBUU) transport code, we estimate the properties of nuclear matter that can be created from low-energy heavyion collisions at RAON.We give predictions for the maximum baryon density, the isospin asymmetry and the temperature of nuclear matter that would be formed during 197Au+197Au and 132Sn+64Ni reactions. With a large isospin asymmetry, various theoretical studies indicate that the critical densities or temperatures of phase transitions to exotic states decrease. Because a large isospin asymmetry is expected in the dense matter created at RAON, we discuss possibilities of observing exotic states of dense nuclear matter at RAON for large isospin asymmetry.

  20. Dense high temperature ceramic oxide superconductors

    Science.gov (United States)

    Landingham, Richard L.

    1993-01-01

    Dense superconducting ceramic oxide articles of manufacture and methods for producing these articles are described. Generally these articles are produced by first processing these superconducting oxides by ceramic processing techniques to optimize materials properties, followed by reestablishing the superconducting state in a desired portion of the ceramic oxide composite.

  1. Denseness of Numerical Radius Attaining Holomorphic Functions

    Directory of Open Access Journals (Sweden)

    Lee HanJu

    2009-01-01

    Full Text Available We study the density of numerical radius attaining holomorphic functions on certain Banach spaces using the Lindenstrauss method. In particular, it is shown that if a complex Banach space is locally uniformly convex, then the set of all numerical attaining elements of is dense in .

  2. Denseness of Numerical Radius Attaining Holomorphic Functions

    Directory of Open Access Journals (Sweden)

    Han Ju Lee

    2009-01-01

    Full Text Available We study the density of numerical radius attaining holomorphic functions on certain Banach spaces using the Lindenstrauss method. In particular, it is shown that if a complex Banach space X is locally uniformly convex, then the set of all numerical attaining elements of A(BX:X is dense in A(BX:X.

  3. Coalescence preference in dense packing of bubbles

    Science.gov (United States)

    Kim, Yeseul; Gim, Bopil; Gim, Bopil; Weon, Byung Mook

    2015-11-01

    Coalescence preference is the tendency that a merged bubble from the contact of two original bubbles (parent) tends to be near to the bigger parent. Here, we show that the coalescence preference can be blocked by densely packing of neighbor bubbles. We use high-speed high-resolution X-ray microscopy to clearly visualize individual coalescence phenomenon which occurs in micro scale seconds and inside dense packing of microbubbles with a local packing fraction of ~40%. Previous theory and experimental evidence predict a power of -5 between the relative coalescence position and the parent size. However, our new observation for coalescence preference in densely packed microbubbles shows a different power of -2. We believe that this result may be important to understand coalescence dynamics in dense packing of soft matter. This work (NRF-2013R1A22A04008115) was supported by Mid-career Researcher Program through NRF grant funded by the MEST and also was supported by Ministry of Science, ICT and Future Planning (2009-0082580) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry and Education, Science and Technology (NRF-2012R1A6A3A04039257).

  4. APT: Action localization Proposals from dense Trajectories

    NARCIS (Netherlands)

    van Gemert, J.C.; Jain, M.; Gati, E.; Snoek, C.G.M.; Xie, X.; Jones, M.W.; Tam, G.K.L.

    2015-01-01

    This paper is on action localization in video with the aid of spatio-temporal proposals. To alleviate the computational expensive video segmentation step of existing proposals, we propose bypassing the segmentations completely by generating proposals directly from the dense trajectories used to repr

  5. Dense ceramic membranes for methane conversion

    NARCIS (Netherlands)

    Bouwmeester, Henny J.M.

    2003-01-01

    Dense ceramic membranes made from mixed oxygen-ionic and electronic conducting perovskite-related oxides allow separation of oxygen from an air supply at elevated temperatures (>700 °C). By combining air separation and catalytic partial oxidation of methane to syngas into a ceramic membrane reactor,

  6. Improvements in accuracy of dense OPC models

    Science.gov (United States)

    Kallingal, Chidam; Oberschmidt, James; Viswanathan, Ramya; Abdo, Amr; Park, OSeo

    2008-10-01

    Performing model-based optical proximity correction (MBOPC) on layouts has become an integral part of patterning advanced integrated circuits. Earlier technologies used sparse OPC, the run times of which explode when the density of layouts increases. With the move to 45 nm technology node, this increase in run time has resulted in a shift to dense simulation OPC, which is pixel-based. The dense approach becomes more efficient at 45nm technology node and beyond. New OPC model forms can be used with the dense simulation OPC engine, providing the greater accuracy required by smaller technology nodes. Parameters in the optical model have to be optimized to achieve the required accuracy. Dense OPC uses a resist model with a different set of parameters than sparse OPC. The default search ranges used in the optimization of these resist parameters do not always result in the best accuracy. However, it is possible to improve the accuracy of the resist models by understanding the restrictions placed on the search ranges of the physical parameters during optimization. This paper will present results showing the correlation between accuracy of the models and some of these optical and resist parameters. The results will show that better optimization can improve the model fitness of features in both the calibration and verification set.

  7. Building a dense surface map incrementally from semi-dense point cloud and RGB images

    Institute of Scientific and Technical Information of China (English)

    Qian-shan LI; Rong XIONG; Shoudong HUANG; Yi-ming HUANG

    2015-01-01

    Building and using maps is a fundamental issue for bionic robots in fi eld applications. A dense surface map, which offers rich visual and geometric information, is an ideal representation of the environment for indoor/outdoor localization, navigation, and recognition tasks of these robots. Since most bionic robots can use only small light-weight laser scanners and cameras to acquire semi-dense point cloud and RGB images, we propose a method to generate a consistent and dense surface map from this kind of semi-dense point cloud and RGB images. The method contains two main steps: (1) generate a dense surface for every single scan of point cloud and its corresponding image(s) and (2) incrementally fuse the dense surface of a new scan into the whole map. In step (1) edge-aware resampling is realized by segmenting the scan of a point cloud in advance and resampling each sub-cloud separately. Noise within the scan is reduced and a dense surface is generated. In step (2) the average surface is estimated probabilistically and the non-coincidence of different scans is eliminated. Experiments demonstrate that our method works well in both indoor and outdoor semi-structured environments where there are regularly shaped ob jects.

  8. Unilateral pulmonary hypoplasia

    Directory of Open Access Journals (Sweden)

    Albay S

    2008-10-01

    Full Text Available Pulmonary hypoplasia represents a broad range of malformations characterized by incomplete development of lung tissue. The severity of the lesion depends on the appearance time of the malformation during the timeline of lung development, and the presence of further anatomic anomalies. In this report, we present a case of pulmonary hypoplasia in a 27-year old woman.

  9. Pregnancy and pulmonary hypertension

    NARCIS (Netherlands)

    Pieper, Petronella G.; Lameijer, Heleen; Hoendermis, Elke S.

    2014-01-01

    Pulmonary hypertension during pregnancy is associated with considerable risks of maternal mortality and morbidity. Our systematic review of the literature on the use of targeted treatments for pulmonary arterial hypertension during pregnancy indicates a considerable decrease of mortality since a pre

  10. Pulmonary Hypertension in Scleroderma

    Science.gov (United States)

    ... is a reduced diffusing capacity (DL CO ) on pulmonary function tests (PFTs). The DL CO measures the ability of ... catheterization to measure the actual pressure in the pulmonary ... the PH; to assess the function of the left side of the heart; and ...

  11. Pulmonary Function Tests

    OpenAIRE

    Ranu, H; Wilde, M.; Madden, B

    2011-01-01

    Pulmonary function tests are valuable investigations in the management of patients with suspected or previously diagnosed respiratory disease. They aid diagnosis, help monitor response to treatment and can guide decisions regarding further treatment and intervention. The interpretation of pulmonary functions tests requires knowledge of respiratory physiology. In this review we describe investigations routinely used and discuss their clinical implications.

  12. [Mediastino-pulmonary sarcoidosis].

    Science.gov (United States)

    Delaval, P; Desrues, B; Quinquenel, M L; Lineau, C; Lena, H

    1993-01-01

    Sarcoidosis is diffuse granulomatosis disease. The aetiology and pathogenesis are unknown. Many different localizations have been described together with immunological disturbances. Generally, the prognosis is favourable. Here we describe the pulmonary manifestations and their staging. Extra-pulmonary manifestations are then presented. Finally, the principle elements of the diagnosis and the treatment of sarcoidosis are discussed.

  13. Survivin在后发性白内障动物模型中的表达%Expression of survivin in animal model of posterior capsule opacification

    Institute of Scientific and Technical Information of China (English)

    刘淑君; 代秀玉; 刘少义; 王文亭; 李元彬

    2014-01-01

    Objective To establish animal model of posterior capsule opacification ( PCO) in New Zealand white rab-bits and detect survivin expression in PCO tissue.Methods Thirty adult New Zealand white rabbits were randomly divided into control group and experimental group.The 5 rabbits in control group were executed.Ultrasonic phacoemul-sification was performed in the 25 experimental rabbits'eyes.Their eyes were examined by slit lamp microscope to observe the development of PCO immediately and 3, 7, 14 and 28 days after surgery, and then they were executed.The posterior capsule of right eyes was taken in all the rabbits.Western blotting and reverse transcription polymerase ( RT-PCR) were performed to detect survivin expression in PCO at different time points postoperatively.Results Both Western blotting and RT-PCR method indicated that different level of survivin expression was detected in the tissue of PCO 3, 7, 14 and 28 days after surgery.It reached the peak at the 7th day, and began to decrease at the 14th day after surgery.Conclusion The survivin expression can be detected in the tissue of PCO in certain time, which indicated that survivin is correlated with the pathogenesis of PCO.%目的:建立新西兰大白兔后发性白内障( PCO)动物模型,检测凋亡抑制因子Survivin在PCO中的表达,探讨Survivin在PCO形成过程中的作用。方法选用健康新西兰大白兔30只,随机分为对照组(5只)、实验组(25只)。对照组直接处死;实验组行右眼晶状体超声乳化吸出术,分别于术后即刻,3、7、14、28 d(每个时间点5只)对术眼行裂隙灯显微镜检查,然后处死。获取对照组及实验组右眼撕除部分前囊膜的囊袋,采用Western blotting和逆转录聚合酶链反应( RT-PCR)方法检测Survivin在对照组及实验组不同时间点PCO中的表达。结果 Western blotting和RT-PCR在对照组及实验组术后即刻均未检测到Survivin的表达,实验组术后3

  14. Clinical study of posterior capsule opacification%后发性白内障相关因素的临床研究

    Institute of Scientific and Technical Information of China (English)

    郭未艾; 王晓黎; 吴文捷; 张振平

    2005-01-01

    目的观察超声乳化白内障吸除联合折叠人工晶状体植入术后后发性白内障(posterior capsule opacification,PCO)发生的相关因素及其特点.方法随访观察394例 (440只眼)白内障患者超声乳化白内障吸除联合囊袋内折叠人工晶状体植入术后的视力,用内置数码摄像头Zeiss 120裂隙灯进行眼底后反光裂隙照相,转化成数码图像输入计算机,观察人工晶状体位置、连续环形撕囊和后囊膜混浊等情况.随访时间2~58个月,平均14个月. 按照晶状体类型共分为6组:Sensar组113例(123只眼),Acrysof三片组129例(157只眼),Acrysof一片组79例(84只眼),SC60B组23例(26只眼), 硅凝胶组50例(50只眼).获得的照片使用德国EPCO2000软件分析,对PCO程度进行评分并将各组进行比较分析.结果完全没有PCO的有19只眼(占4.32%),存在PCO的有421只眼(占95.68%),PCO波及瞳孔中央3 mm的有274只眼(占62.27%).按人工晶状体光学面材料分组的两组中,对应PCO数值进行比较,总分差异无显著性(t=1.470,P=0.143);按照襻的成角分组的四组中,所对应的PCO数值中1级混浊的数值比较,差异有显著性(F=4.054,P=0.007);按边缘设计不同分组的两组中,对应PCO数值比较,总分差异有显著性(t=3.763,P=0.0001);根据连续环形撕囊分组的3组中,所对应的PCO数值比较,总分差异有显著性(F=3.689,P=0.026).结论后囊膜混浊的发生与人工晶状体材料无相关性;襻与光学面成角为10°的人工晶状体对PCO的早期形成有抑制作用;直角边缘设计可以减少PCO的形成;连续环形撕囊口完全覆盖人工晶状体光学面抑制了后囊膜混浊的发生几率.

  15. Pulmonary mycoses among the clinically suspected cases of pulmonary tuberculosis

    OpenAIRE

    Tshering Ongmu Bhutia; Luna Adhikari

    2015-01-01

    Background: This study was carried with the main objectives: (1) to find out the occurrence of pulmonary mycoses in clinically suspected pulmonary tuberculosis cases at central referral hospital, Tadong, Sikkim. (2) To find out the various fungi causing pulmonary mycoses in clinically suspected pulmonary tuberculosis cases. Methods: 200 clinically suspected pulmonary tuberculosis cases who visited the department of microbiology for the diagnostic microscopic examination of sputum sample f...

  16. Dense Output for Strong Stability Preserving Runge–Kutta Methods

    KAUST Repository

    Ketcheson, David I.

    2016-12-10

    We investigate dense output formulae (also known as continuous extensions) for strong stability preserving (SSP) Runge–Kutta methods. We require that the dense output formula also possess the SSP property, ideally under the same step-size restriction as the method itself. A general recipe for first-order SSP dense output formulae for SSP methods is given, and second-order dense output formulae for several optimal SSP methods are developed. It is shown that SSP dense output formulae of order three and higher do not exist, and that in any method possessing a second-order SSP dense output, the coefficient matrix A has a zero row.

  17. Colloquium: Nonlinear Collective Interactions in Dense Plasmas

    CERN Document Server

    Shukla, P K

    2010-01-01

    The current understanding of some important collective processes in dense quantum plasmas is presented. After reviewing the basic properties of dense quantum plasmas with degenerate electrons, we present model equations (e.g. the quantum hydrodynamic and effective nonlinear Schr\\"odinger-Poisson equations) that describe collective nonlinear phenomena at nanoscales. The effects of the electron degeneracy arise due to Heisenberg's uncertainty principle and Pauli's exclusion principle for overlapping electron wave functions that result in a nonlinear quantum electron pressure and tunneling/diffusion of electrons through a nonlinear quantum Bohm potential. Since degenerate electrons have $1/2-$spin due to their Fermionic nature, there also appear a spin electron current and a spin force acting on the electrons due to the Bohr magnetization. The present nonlinear equations do not include strong electron correlations and electron-exchange interactions. The quantum effects caused by the electron degeneracy produce n...

  18. Active fluidization in dense glassy systems.

    Science.gov (United States)

    Mandal, Rituparno; Bhuyan, Pranab Jyoti; Rao, Madan; Dasgupta, Chandan

    2016-07-20

    Dense soft glasses show strong collective caging behavior at sufficiently low temperatures. Using molecular dynamics simulations of a model glass former, we show that the incorporation of activity or self-propulsion, f0, can induce cage breaking and fluidization, resulting in the disappearance of the glassy phase beyond a critical f0. The diffusion coefficient crosses over from being strongly to weakly temperature dependent as f0 is increased. In addition, we demonstrate that activity induces a crossover from a fragile to a strong glass and a tendency of active particles to cluster. Our results are of direct relevance to the collective dynamics of dense active colloidal glasses and to recent experiments on tagged particle diffusion in living cells.

  19. Strategies for Dense Optical CDMA Communication Systems

    Institute of Scientific and Technical Information of China (English)

    WANG Yu-bao; LIN Jin-tong

    2005-01-01

    In this paper,we have formulated a strategy that the limited available code sequences in pure Direct-Sequence(DS)or Frequency-Hopping(FH)system can be reused to realize dense optical CDMA:the strategy of novel hybrid DS/FH system.In which,the case that there are n users employing the same FH pattern but different DS code patterns is considered.On the condition that the impact of channel noises is neglected,the upper bound probability of error is evaluated based on the stationary random process theory.The results show that the hybrid system is suitable for Dense Optical CDMA(DOCDMA)communication.Moreover,the problems such as the link-impairment,dispersion of group velocity,etc.in the pure(DS or FH)system can be solved effectively.

  20. The kinetic chemistry of dense interstellar clouds

    Science.gov (United States)

    Graedel, T. E.; Langer, W. D.; Frerking, M. A.

    1982-01-01

    A model of the time-dependent chemistry of dense interstellar clouds is formulated to study the dominant chemical processes in carbon and oxygen isotope fractionation, the formation of nitrogen-containing molecules, and the evolution of product molecules as a function of cloud density and temperature. The abundances of the dominant isotopes of the carbon- and oxygen-bearing molecules are calculated. The chemical abundances are found to be quite sensitive to electron concentration since the electron concentration determines the ratio of H3(+) to He(+), and the electron density is strongly influenced by the metals abundance. For typical metal abundances and for H2 cloud density not less than 10,000 molecules/cu cm, nearly all carbon exists as CO at late cloud ages. At high cloud density, many aspects of the chemistry are strongly time dependent. Finally, model calculations agree well with abundances deduced from observations of molecular line emission in cold dense clouds.

  1. Topological Surface States in Dense Solid Hydrogen.

    Science.gov (United States)

    Naumov, Ivan I; Hemley, Russell J

    2016-11-11

    Metallization of dense hydrogen and associated possible high-temperature superconductivity represents one of the key problems of physics. Recent theoretical studies indicate that before becoming a good metal, compressed solid hydrogen passes through a semimetallic stage. We show that such semimetallic phases predicted to be the most stable at multimegabar (∼300  GPa) pressures are not conventional semimetals: they exhibit topological metallic surface states inside the bulk "direct" gap in the two-dimensional surface Brillouin zone; that is, metallic surfaces may appear even when the bulk of the material remains insulating. Examples include hydrogen in the Cmca-12 and Cmca-4 structures; Pbcn hydrogen also has metallic surface states but they are of a nontopological nature. The results provide predictions for future measurements, including probes of possible surface superconductivity in dense hydrogen.

  2. Highly Dense Isolated Metal Atom Catalytic Sites

    DEFF Research Database (Denmark)

    Chen, Yaxin; Kasama, Takeshi; Huang, Zhiwei

    2015-01-01

    Atomically dispersed noble-metal catalysts with highly dense active sites are promising materials with which to maximise metal efficiency and to enhance catalytic performance; however, their fabrication remains challenging because metal atoms are prone to sintering, especially at a high metal...... loading. A dynamic process of formation of isolated metal atom catalytic sites on the surface of the support, which was achieved starting from silver nanoparticles by using a thermal surface-mediated diffusion method, was observed directly by using in situ electron microscopy and in situ synchrotron X......-ray diffraction. A combination of electron microscopy images with X-ray absorption spectra demonstrated that the silver atoms were anchored on five-fold oxygen-terminated cavities on the surface of the support to form highly dense isolated metal active sites, leading to excellent reactivity in catalytic oxidation...

  3. Accelerating Dense Linear Algebra on the GPU

    DEFF Research Database (Denmark)

    Sørensen, Hans Henrik Brandenborg

    and matrix-vector operations on GPUs. Such operations form the backbone of level 1 and level 2 routines in the Basic Linear Algebra Subroutines (BLAS) library and are therefore of great importance in many scientific applications. The target hardware is the most recent NVIDIA Tesla 20-series (Fermi...... architecture). Most of the techniques I discuss for accelerating dense linear algebra are applicable to memory-bound GPU algorithms in general....

  4. Observations of Plasmons in Warm Dense Matter

    Energy Technology Data Exchange (ETDEWEB)

    Glenzer, S H; Landen, O L; Neumayer, P; Lee, R W; Widmann, K; Pollaine, S W; Wallace, R J; Gregori, G; Holl, A; Bornath, T; Thiele, R; Schwarz, V; Kraeft, W; Redmer, R

    2006-09-05

    We present the first collective x-ray scattering measurements of plasmons in solid-density plasmas. The forward scattering spectra of a laser-produced narrow-band x-ray line from isochorically heated beryllium show that the plasmon frequency is a sensitive measure of the electron density. Dynamic structure calculations that include collisions and detailed balance match the measured plasmon spectrum indicating that this technique will enable new applications to determine the equation of state and compressibility of dense matter.

  5. Splashing onset in dense suspension droplets

    OpenAIRE

    Peters, Ivo; Xu, Qin; Jaeger, Heinrich M.

    2013-01-01

    We investigate the impact of droplets of dense suspensions onto a solid substrate. We show that a global hydrodynamic balance is unable to predict the splash onset and propose to replace it by an energy balance at the level of the particles in the suspension. We experimentally verify that the resulting, particle-based Weber number gives a reliable, particle size and density dependent splash onset criterion. We further show that the same argument also explains why, in bimodal systems, smaller ...

  6. Pulmonary manifestations of leptospirosis

    Directory of Open Access Journals (Sweden)

    Sameer Gulati

    2012-01-01

    Full Text Available Leptospirosis has a spectrum of presentation which ranges from mild disease to a severe form comprising of jaundice and renal failure. Involvement of the lung can vary from subtle clinical features to deadly pulmonary hemorrhage and acute respiratory distress syndrome. Of late, it has been identified that leptospirosis can present atypically with predominant pulmonary manifestations. This can delay diagnosis making and hence optimum treatment. The purpose of this review is to bring together all the reported pulmonary manifestations of leptospirosis and the recent trends in the management.

  7. Anesthesia and pulmonary hypertension.

    Science.gov (United States)

    McGlothlin, Dana; Ivascu, Natalia; Heerdt, Paul M

    2012-01-01

    Anesthesia and surgery are associated with significantly increased morbidity and mortality in patients with pulmonary hypertension due mainly to right ventricular failure, arrhythmias, postoperative hypoxemia, and myocardial ischemia. Preoperative risk assessment and successful management of patients with pulmonary hypertension undergoing cardiac surgery involve an understanding of the pathophysiology of the disease, screening of patients at-risk for pulmonary arterial hypertension, analysis of preoperative and operative risk factors, thorough multidisciplinary planning, careful intraoperative management, and early recognition and treatment of postoperative complications. This article will cover each of these aspects with particular focus on the anesthetic approach for non-cardiothoracic surgeries.

  8. Isolated pulmonary Goodpasture syndrome.

    Science.gov (United States)

    Harrity, P; Gilbert-Barness, E; Cabalka, A; Hong, R; Zimmerman, J

    1991-01-01

    The case of a 13-year-old girl with Goodpasture syndrome is reported. The presentation at this age with only pulmonary hemorrhage is unusual among Goodpasture syndrome patients. The case illustrates well the diagnostic difficulties in Goodpasture syndrome. The choices of treatment modalities available for this disease and the results and risks of such treatment options are reviewed. A discussion and classification of diffuse pulmonary hemorrhage is presented. The case emphasizes that Goodpasture syndrome should be considered in the differential diagnosis of diffuse pulmonary hemorrhage in spite of a lack of renal abnormalities and that serum anti-glomerular basement membrane antibody testing can be of great help in confirming the diagnosis.

  9. A method for dense packing discovery

    CERN Document Server

    Kallus, Yoav; Gravel, Simon

    2010-01-01

    The problem of packing a system of particles as densely as possible is foundational in the field of discrete geometry and is a powerful model in the material and biological sciences. As packing problems retreat from the reach of solution by analytic constructions, the importance of an efficient numerical method for conducting de novo (from-scratch) searches for dense packings becomes crucial. In this paper, we use the divide and concur framework to develop a general search method for the solution of periodic constraint problems, and we apply it to the discovery of dense periodic packings. An important feature of the method is the integration of the unit cell parameters with the other packing variables in the definition of the configuration space. The method we present led to improvements in the densest-known tetrahedron packing which are reported in [arXiv:0910.5226]. Here, we use the method to reproduce the densest known lattice sphere packings and the best known lattice kissing arrangements in up to 14 and ...

  10. Hybrid-Based Dense Stereo Matching

    Science.gov (United States)

    Chuang, T. Y.; Ting, H. W.; Jaw, J. J.

    2016-06-01

    Stereo matching generating accurate and dense disparity maps is an indispensable technique for 3D exploitation of imagery in the fields of Computer vision and Photogrammetry. Although numerous solutions and advances have been proposed in the literature, occlusions, disparity discontinuities, sparse texture, image distortion, and illumination changes still lead to problematic issues and await better treatment. In this paper, a hybrid-based method based on semi-global matching is presented to tackle the challenges on dense stereo matching. To ease the sensitiveness of SGM cost aggregation towards penalty parameters, a formal way to provide proper penalty estimates is proposed. To this end, the study manipulates a shape-adaptive cross-based matching with an edge constraint to generate an initial disparity map for penalty estimation. Image edges, indicating the potential locations of occlusions as well as disparity discontinuities, are approved by the edge drawing algorithm to ensure the local support regions not to cover significant disparity changes. Besides, an additional penalty parameter 𝑃𝑒 is imposed onto the energy function of SGM cost aggregation to specifically handle edge pixels. Furthermore, the final disparities of edge pixels are found by weighting both values derived from the SGM cost aggregation and the U-SURF matching, providing more reliable estimates at disparity discontinuity areas. Evaluations on Middlebury stereo benchmarks demonstrate satisfactory performance and reveal the potency of the hybrid-based dense stereo matching method.

  11. Dense Visual SLAM with Probabilistic Surfel Map.

    Science.gov (United States)

    Yan, Zhixin; Ye, Mao; Ren, Liu

    2017-11-01

    Visual SLAM is one of the key technologies to align the virtual and real world together in Augmented Reality applications. RGBD dense Visual SLAM approaches have shown their advantages in robustness and accuracy in recent years. However, there are still several challenges such as the inconsistencies in RGBD measurements across multiple frames that could jeopardize the accuracy of both camera trajectory and scene reconstruction. In this paper, we propose a novel map representation called Probabilistic Surfel Map (PSM) for dense visual SLAM. The main idea is to maintain a globally consistent map with both photometric and geometric uncertainties encoded in order to address the inconsistency issue. The key of our PSM is proper modeling and updating of sensor measurement uncertainties, as well as the strategies to apply them for improving both the front-end pose estimation and the back-end optimization. Experimental results on publicly available datasets demonstrate major improvements with our approach over the state-of-the-art methods. Specifically, comparing with σ-DVO, we achieve a 40% reduction in absolute trajectory error and an 18% reduction in relative pose error in visual odometry, as well as an 8.5% reduction in absolute trajectory error in complete SLAM. Moreover, our PSM enables generation of a high quality dense point cloud with comparable accuracy as the state-of-the-art approach.

  12. Dense Correspondences across Scenes and Scales.

    Science.gov (United States)

    Tau, Moria; Hassner, Tal

    2016-05-01

    We seek a practical method for establishing dense correspondences between two images with similar content, but possibly different 3D scenes. One of the challenges in designing such a system is the local scale differences of objects appearing in the two images. Previous methods often considered only few image pixels; matching only pixels for which stable scales may be reliably estimated. Recently, others have considered dense correspondences, but with substantial costs associated with generating, storing and matching scale invariant descriptors. Our work is motivated by the observation that pixels in the image have contexts-the pixels around them-which may be exploited in order to reliably estimate local scales. We make the following contributions. (i) We show that scales estimated in sparse interest points may be propagated to neighboring pixels where this information cannot be reliably determined. Doing so allows scale invariant descriptors to be extracted anywhere in the image. (ii) We explore three means for propagating this information: using the scales at detected interest points, using the underlying image information to guide scale propagation in each image separately, and using both images together. Finally, (iii), we provide extensive qualitative and quantitative results, demonstrating that scale propagation allows for accurate dense correspondences to be obtained even between very different images, with little computational costs beyond those required by existing methods.

  13. Numerical modeling for dilute and dense sprays

    Science.gov (United States)

    Chen, C. P.; Kim, Y. M.; Shang, H. M.; Ziebarth, J. P.; Wang, T. S.

    1992-01-01

    We have successfully implemented a numerical model for spray-combustion calculations. In this model, the governing gas-phase equations in Eulerian coordinate are solved by a time-marching multiple pressure correction procedure based on the operator-splitting technique. The droplet-phase equations in Lagrangian coordinate are solved by a stochastic discrete particle technique. In order to simplify the calculation procedure for the circulating droplets, the effective conductivity model is utilized. The k-epsilon models are utilized to characterize the time and length scales of the gas phase in conjunction with turbulent modulation by droplets and droplet dispersion by turbulence. This method entails random sampling of instantaneous gas flow properties and the stochastic process requires a large number of computational parcels to produce the satisfactory dispersion distributions even for rather dilute sprays. Two major improvements in spray combustion modelings were made. Firstly, we have developed a probability density function approach in multidimensional space to represent a specific computational particle. Secondly, we incorporate the Taylor Analogy Breakup (TAB) model for handling the dense spray effects. This breakup model is based on the reasonable assumption that atomization and drop breakup are indistinguishable processes within a dense spray near the nozzle exit. Accordingly, atomization is prescribed by injecting drops which have a characteristic size equal to the nozzle exit diameter. Example problems include the nearly homogeneous and inhomogeneous turbulent particle dispersion, and the non-evaporating, evaporating, and burning dense sprays. Comparison with experimental data will be discussed in detail.

  14. CT of the chest in the evaluation of idiopathic pulmonary arterial hypertension in children

    Energy Technology Data Exchange (ETDEWEB)

    Chaudry, Gulraiz [University of Toronto, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto (Canada); Children' s Hospital Boston, Department of Radiology, Boston, MA (United States); MacDonald, Cathy; Gundogan, Munire; Manson, David [University of Toronto, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto (Canada); Adatia, Ian [UCSF Children' s Hospital, Department of Pediatric Cardiology, San Francisco, CA (United States)

    2007-04-15

    Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease in children. By definition it is a diagnosis of exclusion, and CT of the chest is primarily performed to exclude other causes. Previous studies have defined CT features suggestive of the diagnosis of IPAH, but these have all been limited to the adult population. Contrast-enhanced chest CT and high-resolution CT findings in IPAH were evaluated in an attempt to define features consistently seen in children with this condition. The chest CT scans performed at initial presentation were reviewed in 17 children with echocardiographic or angiographic evidence of IPAH. There were nine boys and eight girls, ranging in age from 1 month to 17 years. The extrapulmonary findings included cardiomegaly with right-sided cardiac enlargement, which was seen in 13 children. The central pulmonary arteries were enlarged in 15 children, with peripheral enlargement in two. In six children this resulted in bronchial compression. In addition, mediastinal and hilar lymphadenopathy was noted in three children. Prominent intrapulmonary features included a peripheral vasculopathy, with enlarged tortuous vessels, seen in eight children. Ill-defined ground-glass centrilobular opacities were also noted in eight children, representing the most common parenchymal abnormality. Other findings included septal lines in five, diffuse ground-glass opacification in four and focal hyperlucent zones in three. Mosaic attenuation was seen in one child. A variety of imaging findings are identified in IPAH. Features particularly consistent with the diagnosis include peripheral vasculopathy and centrilobular opacities in the setting of cardiomegaly and central pulmonary arterial enlargement. (orig.)

  15. Management of pulmonary aspiration

    NARCIS (Netherlands)

    Janda, Matthias; Scheeren, Thomas W L; Nöldge-Schomburg, Gabriele F E

    2006-01-01

    Pulmonary aspiration of gastric contents in the perioperative phase is associated with increased postoperative morbidity and mortality. For the management of aspiration, differentiation between acid-associated aspiration pneumonitis and aspiration pneumonia as a consequence of a secondary bacterial

  16. Pulmonary neuroendocrine (carcinoid) tumors

    DEFF Research Database (Denmark)

    Caplin, M E; Baudin, E; Ferolla, P

    2015-01-01

    carried out in PubMed for the terms 'pulmonary neuroendocrine tumors', 'bronchial neuroendocrine tumors', 'bronchial carcinoid tumors', 'pulmonary carcinoid', 'pulmonary typical/atypical carcinoid', and 'pulmonary carcinoid and diagnosis/treatment/epidemiology/prognosis'. A systematic review...... of the relevant literature was carried out, followed by expert review. RESULTS: PCs are well-differentiated neuroendocrine tumors and include low- and intermediate-grade malignant tumors, i.e. typical (TC) and atypical carcinoid (AC), respectively. Contrast CT scan is the diagnostic gold standard for PCs......, particularly of low-grade TC and AC. Locoregional or radiotargeted therapies should be considered for metastatic disease. Systemic chemotherapy is used for progressive PCs, although cytotoxic regimens have demonstrated limited effects with etoposide and platinum combination the most commonly used, however...

  17. Pulmonary valve stenosis

    Science.gov (United States)

    ... valvuloplasty - pulmonary Images Heart valves References Carabello BA. Valvular heart disease. In: Goldman L, Schafer AI, eds. Goldman's Cecil ... Saunders; 2016:chap 69. Otto CM, Bownow RO. Valvular heart disease. In: Mann DL, Zipes DP, Libby P, Bonow ...

  18. Pulmonary Arteriovenous Malformations

    DEFF Research Database (Denmark)

    Kjeldsen, A D; Oxhøj, H; Andersen, P E

    1999-01-01

    Hereditary hemorrhagic telangiectasia (HHT) is a dominantly inherited disease with a high prevalence of pulmonary arteriovenous malformations (PAVMs). The first symptom of HHT may be stroke or fatal hemoptysis associated with the presence of PAVM....

  19. Neonatal pulmonary artery thrombosis

    Directory of Open Access Journals (Sweden)

    Mangesh Jadhav

    2012-01-01

    Full Text Available Pulmonary artery thrombosis in neonates is a rare entity. We describe two neonates with this diagnosis; their presentation, evaluation, and management. These cases highlight the importance of this differential diagnosis when evaluating the cyanotic neonate.

  20. Pulmonary Valve Stenosis

    Science.gov (United States)

    ... growths called carcinoid tumors in the digestive system. Rheumatic fever. This complication of an infection caused by streptococcus ... valve stenosis later in life, including: Carcinoid syndrome Rheumatic fever Noonan's syndrome Mild to moderate pulmonary valve stenosis ...

  1. [Pulmonary Manifestations of Vasculitis].

    Science.gov (United States)

    von Vietinghoff, S

    2016-11-01

    The variable symptoms and signs of pulmonary vasculitis are a diagnostic and therapeutic challenge. Vasculitis should be considered in rapidly progressing, severe and unusual manifestations of pulmonary disease. Clinical examination of other organ systems typically affected by vasculitis such as skin and kidney and autoantibody measurements are complementary approaches to manage this situation. Pulmonary involvement is common in small vessel vasculitis including anti-GBM disease (Goodpasture syndrome) and the ANCA-associated vasculitides. Life threatening pulmonary hemorrhage and irreversible damage of other organs, frequently the kidney, are important complications necessitating rapid diagnosis of these conditions.Vasculitides are rare diseases of multiple organs and therapies including biologics are evolving rapidly, requiring cooperation of specialities and with specialized centres to achieve best patient care. All involved physicians should be aware of typical complications of immunosuppressive therapy. © Georg Thieme Verlag KG Stuttgart · New York.

  2. Reperfusion pulmonary edema

    Energy Technology Data Exchange (ETDEWEB)

    Klausner, J.M.; Paterson, I.S.; Mannick, J.A.; Valeri, C.R.; Shepro, D.; Hechtman, H.B. (Harvard Medical School, Boston, MA (USA))

    1989-02-17

    Reperfusion following lower-torso ischemia in humans leads to respiratory failure manifest by pulmonary hypertension, hypoxemia, and noncardiogenic pulmonary edema. The mechanism of injury has been studied in the sheep lung lymph preparation, where it has been demonstrated that the reperfusion resulting in pulmonary edema is due to an increase in microvascular permeability of the lung to protein. This respiratory failure caused by reperfusion appears to be an inflammatory reaction associated with intravascular release of the chemoattractants leukotriene B{sub 4} and thromboxane. Histological studies of the lung in experimental animals revealed significant accumulation of neutrophils but not platelets in alveolar capillaries. The authors conclude that thromboxane generated and released from the ischemic tissue is responsible for the transient pulmonary hypertension. Second, it is likely that the chemoattractants are responsible for leukosequestration, and third, neutrophils, oxygen-derived free radicals, and thromboxane moderate the altered lung permeability.

  3. Pulmonary mycosis in AIDS

    Energy Technology Data Exchange (ETDEWEB)

    Busi Rizzi, Elisa; Schinina, Vincenzo; Bellussi, Angelo; De Santis, Andrea; Mazzuoli, Giovanna; Giosue, Sandro; Bibbolino, Corrado

    2001-01-01

    We retrospectively reviewed our series of 35 pulmonary mycosis in patients with AIDS, observed from 1987 to 1999, to correlate the imaging and pathologic findings. We further evaluated the frequency of fungal pneumonia before and after the use of a highly active antiretroviral therapy (HAART). Early recognition of pulmonary mycosis is imperative in these patients and improved survival can be achieved with early CT detection and prompt institution of high-dose antifungal therapy.

  4. Chronic obstructive pulmonary disease

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008430 Effect of gas exchange at maximal intensity on exercise capacity in patients with chronic obstructive pulmonary disease. WANG Haoyan(王浩彦), et al. Dept Respir Dis, Beijing Friendship Hosp, Capital Med Sci Univ, Beijing 100050. Chin J Tuberc Respir Dis 2008;31(6):414-416. Objective To investigate the effect of gas exchange at maximal intensity on exercise capacity in patients with chronic obstructive pulmonary disease (COPD).

  5. Reexpansion pulmonary edema

    OpenAIRE

    Genofre Eduardo Henrique; Vargas Francisco S.; Teixeira Lisete R.; Vaz Marcelo Alexandre Costa; Marchi Evaldo

    2003-01-01

    Reexpansion pulmonary edema (RPE) is a rare, but frequently lethal, clinical condition. The precise pathophysiologic abnormalities associated with this disorder are still unknown, though decreased pulmonary surfactant levels and a pro-inflammatory status are putative mechanisms. Early diagnosis is crucial, since prognosis depends on early recognition and prompt treatment. Considering the high mortality rates related to RPE, preventive measures are still the best available strategy for patient...

  6. Traumatic pulmonary pseudocyst.

    Science.gov (United States)

    Gupta, Neeraj; George, Jacob; Gupta, Rakesh C; Dixit, Ramakant

    2013-04-01

    Blunt thoracic trauma manifests in various ways, depending on the structures injured and type of injury. Commonly manifested as parenchymal contusion, at times, pseudacavitation may also been seen on the chest X ray. They are to be differentiated from other causes of pulmonary cavitations which are often done based on history. The so called pulmonary pseudo cysts usually have a benign course and needs only observation.

  7. Traumatic pulmonary pseudocyst

    OpenAIRE

    Gupta, Neeraj; George, Jacob; Gupta, Rakesh C; Dixit, Ramakant

    2013-01-01

    Blunt thoracic trauma manifests in various ways, depending on the structures injured and type of injury. Commonly manifested as parenchymal contusion, at times, pseudacavitation may also been seen on the chest X ray. They are to be differentiated from other causes of pulmonary cavitations which are often done based on history. The so called pulmonary pseudo cysts usually have a benign course and needs only observation.

  8. Quantification of posterior capsular opacification after cataract surgery%白内障手术后后囊膜混浊的量化比较

    Institute of Scientific and Technical Information of China (English)

    丁衍; 柳林; 赵世红

    2009-01-01

    目的 评估白内障术后疏水件丙烯酸人工晶状体SensarAR40e和硅胶人工晶状体的后囊膜混浊(PCO),并用能客观评估PCO的软件量化分析.方法 共选择98只眼行标准的超声乳化白内障吸除术,人工晶状体囊袋内固定.所有眼随机植入Sensar AR40e或硅胶人工晶状体,但同一患者植入的人工晶状体必须不同.在第1年和第2年时后照法拍摄后囊膜图像,通过去除浦肯野反光、增强对比度、过滤后增强低密度的PCO等方法处理后用POCO软件分析对比.结果 术后1年疏水性丙烯酸人工晶状体PCO为(0.32±0.13)%硅胶人工晶状体为(0.39±0.17)%(P=0.37).2年时疏水性丙烯酸人工晶状体PCO为(0.42±0.20)%,硅胶品状体为(0.34±0.18)%(P=0.50).患者术后1年,2年时疏水性丙烯酸人工品状体PCO的严重级别分别是(0.50±0.30)和(0.82±0.58),‘亏硅胶人工晶状体的(0.63±0.35)和(0.55±0.35)相比,无统计学意义(P<0.05).结论 PCO后囊膜混浊量化分析系统提供了客观而且可重复性强的量化PCO的方法,也是研究预防PCO技术的有力工具.%Objective To evaluate posterior capsular opacification(PCO)with hydrophnbie and use a software program developed to provide an objective assessment of the amount of PCO in digital images of the posterior capsule to quantify PCO.Methods Ninety-eight eyes underwent standardized phacoemulasification and "in the bag" IOL placement.They were randomized to receive a three piece lens of hydrophobic or silicone,but lens materials is different in one case.On years 1 and 2 digitized retroillumination images were taken of the posterior capsule.Images were analyzed by POCO software program,removing the Purkinje light reflexes,contrast enhancement,filtering to enhance low-density PCO.Results Percentage PCO were in 0.32±0.13 ofhydrophobic acrylic IOLs at year 1,compared with 0.39±0.17 of silicone(P=0.37).At year 2,percentage PCO were in 0.42+0.20 with hydrophobic acrylic IOLs,0.344

  9. Quantification of posterior capsular opacification after cataract surgery%白内障术后后囊膜混浊的量化分析

    Institute of Scientific and Technical Information of China (English)

    丁衍; 柳林; 赵世红

    2009-01-01

    目的:评估白内障术后疏水性丙烯酸人工晶状体Sensar AR40e和硅胶人工晶状体的后囊膜混浊(PCO),并用能客观评估PCO的软件量化分析.方法:共选择98眼行标准的超声乳化白内障吸除术,人工晶状体囊袋内固定.所有眼随机植入Sensar AR40e或硅胶人工晶状体,但同一患者植入的人工晶状体必须不同.在第1~2a时后照法拍摄后囊膜图像,通过去除浦肯野反光、增强对比度、过滤后增强低密度的PCO等方法处理后用POCO软件分析对比.结果:术后1a疏水性丙烯酸人工晶状体PCO百分比为0.32±0.13,硅胶人工晶状体为0.39±0.17(P=0.37).2a时疏水性丙烯酸人工晶状体PCO百分比为0.42±0.20,硅胶晶状体为0.34±0.18(P=0.50).患者术后1,2a时疏水性丙烯酸人工晶状体PCO的严重级别分别是0.50±0.30和0.82±0.58,与硅胶人工晶状体的0.63±0.35和0.55±0.35相比,无统计学意义(P=0.52,P=0.69).结论:POCO后囊膜混浊量化分析系统提供了客观而且可重复性强的量化PCO的方法,也是研究预防PCO技术的有力工具.%AIM: To evaluate posterior capsular opacification (PCO) with hydrophobic acrylic intraocular lens (IOL, Sensar AR40e) and silicone IOLs after cataract surgery, to use a software program developed to provide an objective assessment of the amount of PCO in the digital images of the posterior capsule to quantify PCO. METHODS: Ninety-eight eyes underwent standardized phacoemulsification and "in the bag" IOL placement, were randomized to receive a three piece lens of hydrophobic acrylic or silicone, but lens materials were different in one case. In year 1 and 2, digitized retro-illumination images were taken from the posterior capsule. Images were analyzed by POCO software program, removing the Purkinje light reflexes, contrast enhancement, filtering to enhance low-density PCO. RESULTS: The percentage of PCO were 0.32±0.13 of hydrophobic acrylic IOLs in year 1, compared with 0.39±0.17 of

  10. Use of expiratory CT pulmonary angiography to reduce inspiration and breath-hold associated artefact: Contrast dynamics and implications for scan protocol

    Energy Technology Data Exchange (ETDEWEB)

    Mortimer, A.M., E-mail: alex_mortimer@hotmail.com [Department of Radiology, Bristol Royal Infirmary, Bristol (United Kingdom); Singh, R.K.; Hughes, J.; Greenwood, R.; Hamilton, M.C.K. [Department of Radiology, Bristol Royal Infirmary, Bristol (United Kingdom)

    2011-12-15

    Aim: To investigate the effects of scanning in expiration during computed tomography pulmonary angiography (CTPA). Materials and methods: One hundred and eighty-one consecutive expiratory CTPA examinations were compared with 145 inspiratory CTPA examinations performed using a standardized protocol through assessment of attenuation seen in the cardiac chambers, pulmonary artery (PA), and ascending aorta. Results: Expiratory scans showed greater attenuation at the pulmonary trunk, right PA, left PA, lobar and segmental PAs (p < 0.05). Expiratory scans showed a lower incidence of transient contrast medium interruption (p < 0.001) and generalized unsatisfactory PA opacification (p < 0.05). Scans with generalized low PA attenuation had lower attenuation in the right ventricle, left heart, and ascending aorta (p < 0.001) suggesting that contrast medium delivery or dilution prior to contrast medium entry into the PA is responsible. Expiratory scans showed lower quality scores (p < 0.001) for depiction of lung parenchyma. Conclusion: Expiratory scanning could be used as an optimal protocol for dedicated PA imaging. However, it suffers from inferior parenchymal imaging and should probably be reserved for failed inspiratory breath-hold CTPA.

  11. Temperature relaxation in dense plasma mixtures

    Science.gov (United States)

    Faussurier, Gérald; Blancard, Christophe

    2016-09-01

    We present a model to calculate temperature-relaxation rates in dense plasma mixtures. The electron-ion relaxation rates are calculated using an average-atom model and the ion-ion relaxation rates by the Landau-Spitzer approach. This method allows the study of the temperature relaxation in many-temperature electron-ion and ion-ion systems such as those encountered in inertial confinement fusion simulations. It is of interest for general nonequilibrium thermodynamics dealing with energy flows between various systems and should find broad use in present high energy density experiments.

  12. Leeuwpan fine coal dense medium plant

    CSIR Research Space (South Africa)

    Lundt, M

    2010-11-01

    Full Text Available availability to treat the higher grade coal (the bottom layer of coal) from the no. 2 Seam for a local and export metallurgical market. Following the path of evolution, in 2007, Leeuwpan commissioned the first double stage ultra-fines dense medium cyclone... plant in the coal industry, to form part of its overall DMS plant. It replaced the spirals to treat the -1 mm material. Spirals are still the most commonly and accepted method used by the industry, but it seems as if the pioneering cyclone process...

  13. Resolving Ultrafast Heating of Dense Cryogenic Hydrogen

    Science.gov (United States)

    Zastrau, U.; Sperling, P.; Harmand, M.; Becker, A.; Bornath, T.; Bredow, R.; Dziarzhytski, S.; Fennel, T.; Fletcher, L. B.; Förster, E.; Göde, S.; Gregori, G.; Hilbert, V.; Hochhaus, D.; Holst, B.; Laarmann, T.; Lee, H. J.; Ma, T.; Mithen, J. P.; Mitzner, R.; Murphy, C. D.; Nakatsutsumi, M.; Neumayer, P.; Przystawik, A.; Roling, S.; Schulz, M.; Siemer, B.; Skruszewicz, S.; Tiggesbäumker, J.; Toleikis, S.; Tschentscher, T.; White, T.; Wöstmann, M.; Zacharias, H.; Döppner, T.; Glenzer, S. H.; Redmer, R.

    2014-03-01

    We report on the dynamics of ultrafast heating in cryogenic hydrogen initiated by a ≲300 fs, 92 eV free electron laser x-ray burst. The rise of the x-ray scattering amplitude from a second x-ray pulse probes the transition from dense cryogenic molecular hydrogen to a nearly uncorrelated plasmalike structure, indicating an electron-ion equilibration time of ˜0.9 ps. The rise time agrees with radiation hydrodynamics simulations based on a conductivity model for partially ionized plasma that is validated by two-temperature density-functional theory.

  14. Oscillating propagators in heavy-dense QCD

    CERN Document Server

    Akerlund, Oscar; Rindlisbacher, Tobias

    2016-10-11

    Using Monte Carlo simulations and extended mean field theory calculations we show that the $3$-dimensional $\\mathbb{Z}_3$ spin model with complex external fields has non-monotonic correlators in some regions of its parameter space. This model serves as a proxy for heavy-dense QCD in $(3+1)$ dimensions. Non-monotonic correlators are intrinsically related to a complex mass spectrum and a liquid-like (or crystalline) behavior. A liquid phase could have implications for heavy-ion experiments, where it could leave detectable signals in the spatial correlations of baryons.

  15. Interference Alignment in Dense Wireless Networks

    CERN Document Server

    Niesen, Urs

    2009-01-01

    We consider arbitrary dense wireless networks, in which $n$ nodes are placed in an arbitrary (deterministic) manner on a square region of unit area and communicate with each other over Gaussian fading channels. We provide inner and outer bounds for the $n\\times n$-dimensional unicast and the $n\\times 2^n$-dimensional multicast capacity regions of such a wireless network. These inner and outer bounds differ only by a factor $O(\\log(n))$, yielding a fairly tight scaling characterization of the entire regions. The communication schemes achieving the inner bounds use interference alignment as a central technique and are surprisingly simple.

  16. Phase transitions in dense 2-colour QCD

    CERN Document Server

    Boz, Tamer; Fister, Leonard; Skullerud, Jon-Ivar

    2013-01-01

    We investigate 2-colour QCD with 2 flavours of Wilson fermion at nonzero temperature T and quark chemical potential mu, with a pion mass of 700 MeV (m_pi/m_rho=0.8). From temperature scans at fixed mu we find that the critical temperature for the superfluid to normal transition depends only very weakly on mu above the onset chemical potential, while the deconfinement crossover temperature is clearly decreasing with mu. We also present results for the Landau-gauge gluon propagator in the hot and dense medium.

  17. Flavour Oscillations in Dense Baryonic Matter

    Science.gov (United States)

    Filip, Peter

    2017-01-01

    We suggest that fast neutral meson oscillations may occur in a dense baryonic matter, which can influence the balance of s/¯s quarks in the nucleus-nucleus and proton-nucleus interactions, if primordial multiplicities of neutral K 0, mesons are sufficiently asymmetrical. The phenomenon can occur even if CP symmetry is fully conserved, and it may be responsible for the enhanced sub-threshold production of multi-strange hyperons observed in the low-energy A+A and p+A interactions.

  18. Gravity-driven dense granular flows

    Energy Technology Data Exchange (ETDEWEB)

    ERTAS,DENIZ; GREST,GARY S.; HALSEY,THOMAS C.; DEVINE,DOV; SILBERT,LEONARDO E.

    2000-03-29

    The authors report and analyze the results of numerical studies of dense granular flows in two and three dimensions, using both linear damped springs and Hertzian force laws between particles. Chute flow generically produces a constant density profile that satisfies scaling relations suggestive of a Bagnold grain inertia regime. The type for force law has little impact on the behavior of the system. Failure is not initiated at the surface, consistent with the absence of surface flows and different principal stress directions at vs. below the surface.

  19. CT findings of pulmonary aspergillosis

    Energy Technology Data Exchange (ETDEWEB)

    Cheon, Jung Eun; Im, Jung Gi; Goo, Jin Mo; Kim, Hong Dae; Han, Man Chung [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1995-10-15

    The fungus aspergillus can cause a variety of pulmonary disorders. Aspergilloma is a noninvasive aspergillus colonization of virtually any type of preexisting pulmonary cavity or cystic space. Invasive pulmonary aspergillosis is serious, usually fatal infection in patients being treated with immunosuppressants or who have chronic debilitating disease. Allergic bronchopulmonary aspergillosis is characterized clinically by asthma, blood and sputum eosinophilia and positive immunologic reaction to aspergillus antigen. Awareness of the radiographic and CT findings of pulmonary aspergillosis is important in making the diagnosis of aspergillus-caused pulmonary disorders. In this pictorial essay, we illustrated various radiological findings of pulmonary aspergillosis focused on CT findings correlated with gross pathologic specimens.

  20. Predicting diffusivities in dense fluid mixtures

    Directory of Open Access Journals (Sweden)

    C. DARIVA

    1999-09-01

    Full Text Available In this work the Enskog solution of the Boltzmann equation, as corrected by Speedy, together with the Weeks-Chandler-Andersen (WCA perturbation theory of liquids is employed in correlating and predicting self-diffusivities of dense fluids. Afterwards this theory is used to estimate mutual diffusion coefficients of solutes at infinite dilution in sub and supercritical solvents. We have also investigated the behavior of Fick diffusion coefficients in the proximity of a binary vapor-liquid critical point since this subject is of great interest for extraction purposes. The approach presented here, which makes use of a density and temperature dependent hard-sphere diameter, is shown to be excellent for predicting diffusivities in dense pure fluids and fluid mixtures. The calculations involved highly nonideal mixtures as well as systems with high molecular asymmetry. The predicted diffusivities are in good agreement with the experimental data for the pure and binary systems. The methodology proposed here makes only use of pure component information and density of mixtures. The simple algebraic relations are proposed without any binary adjustable parameters and can be readily used for estimating diffusivities in multicomponent mixtures.

  1. The symmetry energy in cold dense matter

    CERN Document Server

    Jeong, Kie Sang

    2015-01-01

    We calculate the symmetry energy in cold dense matter both in the normal quark phase and in the 2-color superconductor (2SC) phase. For the normal phase, the thermodynamic potential is calculated by using hard dense loop (HDL) resummation to leading order, where the dominant contribution comes from the longitudinal gluon rest mass. The effect of gluonic interaction to the symmetry energy, obtained from the thermodynamic potential, was found to be small. In the 2SC phase, the non-perturbative BCS paring gives enhanced symmetry energy as the gapped states are forced to be in the common Fermi sea reducing the number of available quarks that can contribute to the asymmetry. We used high density effective field theory to estimate the contribution of gluon interaction to the symmetry energy. Among the gluon rest masses in 2SC phase, only the Meissner mass has iso-spin dependence although the magnitude is much smaller than the Debye mass. As the iso-spin dependence of gluon rest masses is even smaller than the case ...

  2. Symmetry energy in cold dense matter

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Kie Sang, E-mail: k.s.jeong@yonsei.ac.kr; Lee, Su Houng, E-mail: suhoung@yonsei.ac.kr

    2016-01-15

    We calculate the symmetry energy in cold dense matter both in the normal quark phase and in the 2-color superconductor (2SC) phase. For the normal phase, the thermodynamic potential is calculated by using hard dense loop (HDL) resummation to leading order, where the dominant contribution comes from the longitudinal gluon rest mass. The effect of gluonic interaction on the symmetry energy, obtained from the thermodynamic potential, was found to be small. In the 2SC phase, the non-perturbative BCS paring gives enhanced symmetry energy as the gapped states are forced to be in the common Fermi sea reducing the number of available quarks that can contribute to the asymmetry. We used high density effective field theory to estimate the contribution of gluon interaction to the symmetry energy. Among the gluon rest masses in 2SC phase, only the Meissner mass has iso-spin dependence although the magnitude is much smaller than the Debye mass. As the iso-spin dependence of gluon rest masses is even smaller than the case in the normal phase, we expect that the contribution of gluonic interaction to the symmetry energy in the 2SC phase will be minimal. The different value of symmetry energy in each phase will lead to different prediction for the particle yields in heavy ion collision experiment.

  3. Ion Beam Driven Warm Dense Matter Experiments

    Science.gov (United States)

    Bieniosek, F. M.; Henestroza, E.; Leitner, M. A.; Lidia, S. M.; Logan, B. G.; More, R. M.; Ni, P. A.; Seidl, P. A.; Waldron, W. L.; Barnard, J. J.

    2008-11-01

    We report plans and experimental results in ion beam-driven warm dense matter (WDM) experiments. Initial experiments use a 0.3 MeV K+ beam from the NDCX-I accelerator. The WDM conditions are to be achieved by longitudinal and transverse neutralized drift compression to provide a hot spot on the target with a 1-mm beam spot size, and 2-ns pulse length. As a technique for heating matter to high energy density, intense ion beams can deliver precise and uniform beam energy deposition, in a relatively large sample size, and can heat any solid-phase target material. The range of the beams in solid targets is less than 1 micron, which can be lengthened by using reduced density porous targets. We have developed a WDM target chamber and target diagnostics including a fast multi-channel optical pyrometer, optical streak camera, VISAR, and high-speed gated cameras. Initial experiments will explore measurement of temperature and other target parameters. Experiments are planned in areas such as dense electronegative targets, porous target homogenization and two-phase equation of state.

  4. Redesigning Triangular Dense Matrix Computations on GPUs

    KAUST Repository

    Charara, Ali

    2016-08-09

    A new implementation of the triangular matrix-matrix multiplication (TRMM) and the triangular solve (TRSM) kernels are described on GPU hardware accelerators. Although part of the Level 3 BLAS family, these highly computationally intensive kernels fail to achieve the percentage of the theoretical peak performance on GPUs that one would expect when running kernels with similar surface-to-volume ratio on hardware accelerators, i.e., the standard matrix-matrix multiplication (GEMM). The authors propose adopting a recursive formulation, which enriches the TRMM and TRSM inner structures with GEMM calls and, therefore, reduces memory traffic while increasing the level of concurrency. The new implementation enables efficient use of the GPU memory hierarchy and mitigates the latency overhead, to run at the speed of the higher cache levels. Performance comparisons show up to eightfold and twofold speedups for large dense matrix sizes, against the existing state-of-the-art TRMM and TRSM implementations from NVIDIA cuBLAS, respectively, across various GPU generations. Once integrated into high-level Cholesky-based dense linear algebra algorithms, the performance impact on the overall applications demonstrates up to fourfold and twofold speedups, against the equivalent native implementations, linked with cuBLAS TRMM and TRSM kernels, respectively. The new TRMM/TRSM kernel implementations are part of the open-source KBLAS software library (http://ecrc.kaust.edu.sa/Pages/Res-kblas.aspx) and are lined up for integration into the NVIDIA cuBLAS library in the upcoming v8.0 release.

  5. Nucleosynthesis in Hot and Dense Media

    CERN Document Server

    Masood, Samina S

    2014-01-01

    We study the finite temperature and density effects on beta decay rates to compute their contributions to nucleosynthesis. QED type corrections to beta decay from the hot and dense background are estimated in terms of the statistical corrections to the self-mass of an electron. For this purpose, we re-examine the hot and dense background contributions to the electron mass and compute its effect to the beta decay rate, helium yield, energy density of the universe as well as the change in neutrino temperature from the first order contribution to the self-mass of electrons during these processes. We explicitly show that the thermal contribution to the helium abundance at T = m of a cooling universe 0.045 % is higher than the corresponding contribution to helium abundance of a heating universe 0.031% due to the existence of hot fermions before the beginning of nucleosynthesis and their absence after the nucleosynthesis, in the early universe. Thermal contribution to helium abundance was a simple quadratic functio...

  6. Compton scattering measurements from dense plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Glenzer, S H; Neumayer, P; Doeppner, T; Landen, L; Lee, R W; Wallace, R; Weber, S; Lee, H J; Kritcher, A L; Falcone, R; Regan, S P; Sawada, H; Meyerhofer, D D; Gregori, G; Fortmann, C; Schwarz, V; Redmer, R

    2007-10-02

    Compton scattering has been developed for accurate measurements of densities and temperatures in dense plasmas. One future challenge is the application of this technique to characterize compressed matter on the National Ignition Facility where hydrogen and beryllium will approach extremely dense states of matter of up to 1000 g/cc. In this regime, the density, compressibility, and capsule fuel adiabat may be directly measured from the Compton scattered spectrum of a high-energy x-ray line source. Specifically, the scattered spectra directly reflect the electron velocity distribution. In non-degenerate plasmas, the width provides an accurate measure of the electron temperatures, while in partially Fermi degenerate systems that occur in laser-compressed matter it provides the Fermi energy and hence the electron density. Both of these regimes have been accessed in experiments at the Omega laser by employing isochorically heated solid-density beryllium and moderately compressed beryllium foil targets. In the latter experiment, compressions by a factor of 3 at pressures of 40 Mbar have been measured in excellent agreement with radiation hydrodynamic modeling.

  7. Compton scattering measurements from dense plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Glenzer, S H; Neumayer, P; Doeppner, T; Landen, O L; Lee, R W; Wallace, R J; Weber, S [Lawrence Livermore National Laboratory, Livermore, CA (United States); Lee, H J; Kritcher, A L; Falcone, R [University of California Berkeley, Berkeley, CA 94709 (United States); Regan, S P; Sawada, H; Meyerhofer, D D [Laboratory for Laser Energetics, Rochester, NY (United States); Gregori, G [Clarendon Laboratory, University of Oxford, Oxford OX1 3PU (United Kingdom); Fortmann, C; Schwarz, V; Redmer, R [Institut fuer Physik, Universitaet Rostock, D-18051 Rostock (Germany)], E-mail: glenzer1@llnl.gov

    2008-05-15

    Compton scattering techniques have been developed for accurate measurements of densities and temperatures in dense plasmas. One future challenge is the application of this technique to characterize compressed matter on the National Ignition Facility where hydrogen and beryllium will approach extremely dense states of matter of up to 1000 g/cc. In this regime, the density, compressibility, and capsule fuel adiabat may be directly measured from the Compton scattered spectrum of a high-energy x-ray line source. Specifically, the scattered spectra directly reflect the electron velocity distribution. In non-degenerate plasmas, the width provides an accurate measure of the electron temperatures, while in partially Fermi degenerate systems that occur in laser-compressed matter it provides the Fermi energy and hence the electron density. Both of these regimes have been accessed in experiments at the Omega laser by employing isochorically heated solid-density beryllium and moderately compressed beryllium foil targets. In the latter experiment, compressions by a factor of 3 at pressures of 40 Mbar have been measured in excellent agreement with radiation hydrodynamic modeling.

  8. Probing the Physical Structures of Dense Filaments

    Science.gov (United States)

    Li, Di

    2015-08-01

    Filament is a common feature in cosmological structures of various scales, ranging from dark matter cosmic web, galaxy clusters, inter-galactic gas flows, to Galactic ISM clouds. Even within cold dense molecular cores, filaments have been detected. Theories and simulations with (or without) different combination of physical principles, including gravity, thermal balance, turbulence, and magnetic field, can reproduce intriguing images of filaments. The ubiquity of filaments and the similarity in simulated ones make physical parameters, beyond dust column density, a necessity for understanding filament evolution. I report three projects attempting to measure physical parameters of filaments. We derive the volume density of a dense Taurus filament based on several cyanoacetylene transitions observed by GBT and ART. We measure the gas temperature of the OMC 2-3 filament based on combined GBT+VLA ammonia images. We also measured the sub-millimeter polarization vectors along OMC3. These filaments were found to be likely a cylinder-type structure, without dynamic heating, and likely accreting mass along the magnetic field lines.

  9. Wireless Fractal Ultra-Dense Cellular Networks.

    Science.gov (United States)

    Hao, Yixue; Chen, Min; Hu, Long; Song, Jeungeun; Volk, Mojca; Humar, Iztok

    2017-04-12

    With the ever-growing number of mobile devices, there is an explosive expansion in mobile data services. This represents a challenge for the traditional cellular network architecture to cope with the massive wireless traffic generated by mobile media applications. To meet this challenge, research is currently focused on the introduction of a small cell base station (BS) due to its low transmit power consumption and flexibility of deployment. However, due to a complex deployment environment and low transmit power of small cell BSs, the coverage boundary of small cell BSs will not have a traditional regular shape. Therefore, in this paper, we discuss the coverage boundary of an ultra-dense small cell network and give its main features: aeolotropy of path loss fading and fractal coverage boundary. Simple performance analysis is given, including coverage probability and transmission rate, etc., based on stochastic geometry theory and fractal theory. Finally, we present an application scene and discuss challenges in the ultra-dense small cell network.

  10. Quantum molecular dynamics simulations of dense matter

    Energy Technology Data Exchange (ETDEWEB)

    Collins, L.; Kress, J.; Troullier, N.; Lenosky, T.; Kwon, I. [Los Alamos National Lab., Albuquerque, NM (United States)

    1997-12-31

    The authors have developed a quantum molecular dynamics (QMD) simulation method for investigating the properties of dense matter in a variety of environments. The technique treats a periodically-replicated reference cell containing N atoms in which the nuclei move according to the classical equations-of-motion. The interatomic forces are generated from the quantum mechanical interactions of the (between?) electrons and nuclei. To generate these forces, the authors employ several methods of varying sophistication from the tight-binding (TB) to elaborate density functional (DF) schemes. In the latter case, lengthy simulations on the order of 200 atoms are routinely performed, while for the TB, which requires no self-consistency, upwards to 1000 atoms are systematically treated. The QMD method has been applied to a variety cases: (1) fluid/plasma Hydrogen from liquid density to 20 times volume-compressed for temperatures of a thousand to a million degrees Kelvin; (2) isotopic hydrogenic mixtures, (3) liquid metals (Li, Na, K); (4) impurities such as Argon in dense hydrogen plasmas; and (5) metal/insulator transitions in rare gas systems (Ar,Kr) under high compressions. The advent of parallel versions of the methods, especially for fast eigensolvers, presage LDA simulations in the range of 500--1000 atoms and TB runs for tens of thousands of particles. This leap should allow treatment of shock chemistry as well as large-scale mixtures of species in highly transient environments.

  11. Solids flow rate measurement in dense slurries

    Energy Technology Data Exchange (ETDEWEB)

    Porges, K.G.; Doss, E.D.

    1993-09-01

    Accurate and rapid flow rate measurement of solids in dense slurries remains an unsolved technical problem, with important industrial applications in chemical processing plants and long-distance solids conveyance. In a hostile two-phase medium, such a measurement calls for two independent parameter determinations, both by non-intrusive means. Typically, dense slurries tend to flow in laminar, non-Newtonian mode, eliminating most conventional means that usually rely on calibration (which becomes more difficult and costly for high pressure and temperature media). These issues are reviewed, and specific solutions are recommended in this report. Detailed calculations that lead to improved measuring device designs are presented for both bulk density and average velocity measurements. Cross-correlation, chosen here for the latter task, has long been too inaccurate for practical applications. The cause and the cure of this deficiency are discussed using theory-supported modeling. Fluid Mechanics are used to develop the velocity profiles of laminar non-Newtonian flow in a rectangular duct. This geometry uniquely allows the design of highly accurate `capacitive` devices and also lends itself to gamma transmission densitometry on an absolute basis. An absolute readout, though of less accuracy, is also available from a capacitive densitometer and a pair of capacitive sensors yields signals suitable for cross-correlation velocity measurement.

  12. Pulmonary Tuberculosis in Children

    Directory of Open Access Journals (Sweden)

    Keshtkar Jahromi

    2014-09-01

    Full Text Available Tuberculosis (TB is the most common cause of infection-related death worldwide. Children represent 5 to 15% of all TB cases around the world and are more frequently infected and more easily affected by the most severe forms of the disease such as meningitis and disseminated form .Here, we reviewed TB in children with impact on the routes of transmission, clinical manifestations, treatment, control, and prophylaxis. Electronic databases (PubMed, Scopus were searched from June1995 to May 2014 by using key words (pulmonaryTB,epidemiology,transmission,clinical manifestations,treatment,control, and prophylaxis . Pulmonary tuberculosis may manifest in several forms, including endobronchial TB with focal lymphadenopathy, progressive pulmonary disease, pleural involvement, and reactivated pulmonary disease . Symptoms of primary pulmonary disease in the pediatric population are often insignificant. Gastric aspirates are used instead of sputum in children younger than 6 years. BCG vaccination is used in many parts of the world and the major role of vaccination is the prevention of life-threatening illness such as disseminated TB and meningitis in children.Treatment is the same as for adults. Most people infected with M .tuberculosis do not develop active disease. In healthy individuals, the lifetime risk of developing infection to disease is 5-10%. Reactivation of TB often occurs in older children and adolescent and is more common in patients who acquire TB at age 7 years and older.

  13. Pulmonary thromboembolism in children

    Energy Technology Data Exchange (ETDEWEB)

    Babyn, Paul S.; Gahunia, Harpal K. [Hospital for Sick Children, Department of Pediatric Diagnostic Imaging, Toronto, ON (Canada); Massicotte, Patricia [Stollery Children' s Hospital and University of Alberta, Departments of Pediatric Hematology and Cardiology, Edmonton, AB (Canada)

    2005-03-01

    Pulmonary thromboembolism (PTE) is uncommonly diagnosed in the pediatric patient, and indeed often only discovered on autopsy. The incidence of pediatric PTE depends upon the associated underlying disease, diagnostic tests used, and index of suspicion. Multiple risk factors can be found including: peripartum asphyxia, dyspnea, haemoptysis, chest pain, dehydration, septicemia, central venous lines (CVLs), trauma, surgery, ongoing hemolysis, vascular lesions, malignancy, renal disease, foreign bodies or, uncommonly, intracranial venous sinus thrombosis, burns, or nonbacterial thrombotic endocarditis. Other types of embolism can occur uncommonly in childhood and need to be recognized, as the required treatment will vary. These include pulmonary cytolytic thrombi, foreign bodies, tumor and septic emboli, and post-traumatic fat emboli. No single noninvasive test for pulmonary embolism is both sensitive and specific. A combination of diagnostic procedures must be used to identify suspect or confirmed cases of PTE. This article reviews the risk factors, clinical presentation and treatment of pulmonary embolism in children. It also highlights the current diagnostic tools and protocols used to evaluate pulmonary embolism in pediatric patients. (orig.)

  14. Lung irradiation induces pulmonary vascular remodelling resembling pulmonary arterial hypertension

    NARCIS (Netherlands)

    Ghobadi, G.; Bartelds, B.; van der Veen, S. J.; Dickinson, M. G.; Brandenburg, S.; Berger, R. M. F.; Langendijk, J. A.; Coppes, R. P.; van Luijk, P.

    2012-01-01

    Background Pulmonary arterial hypertension (PAH) is a commonly fatal pulmonary vascular disease that is often diagnosed late and is characterised by a progressive rise in pulmonary vascular resistance resulting from typical vascular remodelling. Recent data suggest that vascular damage plays an impo

  15. Fondaparinux vs warfarin for the treatment of unsuspected pulmonary embolism in cancer patients

    Directory of Open Access Journals (Sweden)

    Amato B

    2016-06-01

    Full Text Available Bruno Amato,1,2,* Rita Compagna,1,2,* Aldo Rocca,2 Tommaso Bianco,2 Marco Milone,2 Luigi Sivero,2 Gabriele Vigliotti,2 Maurizio Amato,2 Michele Danzi,2 Giovanni Aprea,2 Luca Gallelli,3,* Stefano de Franciscis,1,4,* Raffaele Serra1,4,* 1Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Viale Europa, Catanzaro, 2Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, 3Department of Health Sciences, 4Department of Medical and Surgical Sciences, University of Catanzaro, Catanzaro, Italy *These authors contributed equally to this work Introduction: In cancer patients, the chest computer tomography (CT can be used to identify asymptomatic pulmonary embolism (APE. In most cases, these patients are treated with anticoagulant drugs for at least 3 months. The American College of Physicians recommend treatment of these patients as patients with symptomatic pulmonary embolism. In this study, we evaluated and compared the efficacy and safety of fondaparinux vs warfarin in the prevention of unsuspected pulmonary embolism in patients with active cancer. Materials and methods: A prospective and parallel group study was performed on 64 cancer patients (29 males and 35 females with APE. A multidetector CT angiography with high spatial and temporal resolution and quality of arterial opacification was used to make the diagnosis. Lung scintigraphy was reserved to selected patients only. Patients were randomized to either the warfarin (Group A or the fondaparinux (Group B for 90 days. The first end point of efficacy was the persistence, reduction, or disappearance of thrombosis after 90 days. The second end point was the reappearance of thrombosis after 1 year. The first end point of safety was the development of major bleeding. Results: We enrolled 32 patients into each treatment group. We reached the

  16. Pulmonary Hypertension: Diagnosis and Treatment

    National Research Council Canada - National Science Library

    Dunlap, Beth; Weyer, George

    2016-01-01

    Pulmonary hypertension is a common, complex group of disorders that result from different pathophysiologic mechanisms but are all defined by a mean pulmonary arterial pressure of 25 mm Hg or greater...

  17. Update in pulmonary arterial hypertension.

    Science.gov (United States)

    Mejía Chew, C R; Alcolea Batres, S; Ríos Blanco, J J

    2016-11-01

    Pulmonary arterial hypertension is a rare and progressive disease that mainly affects the pulmonary arterioles (precapillary), regardless of the triggering aetiology. The prevalence of pulmonary hypertension and pulmonary arterial hypertension in Spain is estimated at 19.2 and 16 cases per million inhabitants, respectively. The diagnosis of pulmonary arterial hypertension is based on haemodynamic criteria (mean pulmonary artery pressure ≥25mmHg, pulmonary capillary wedge pressure ≤15mmHg and pulmonary vascular resistance >3 Wood units) and therefore requires the implementation of right cardiac catheterisation. Sequential therapy with a single drug has been used in clinical practice. However, recent European guidelines recommend combined initial therapy in some situations. This review conducts a critical update of our knowledge of this disease according to the latest guidelines and recommendations.

  18. Lung Transplantation for Pulmonary Hypertension

    Science.gov (United States)

    ... the page. Answers about Lung Transplantation for PULMONARY HYPERTENSION Part One: Overview From the development of epoprostenol ... decades, expansion of medical treatment of pulmonary arterial hypertension (PAH) has improved survival and quality of life ...

  19. Decay of Langmuir wave in dense plasmas and warm dense matter

    CERN Document Server

    Son, S; Moon, Sung Joon

    2010-01-01

    The decays of the Langmuir waves in dense plasmas are computed using the dielectric function theory widely used in the solid state physics. Four cases are considered: a classical plasma, a Maxwellian plasma, a degenerate quantum plasma, and a partially degenerate plasma. The result is considerably different from the conventional Landau damping theory.

  20. Pulmonary embolism; Lungenarterienembolie

    Energy Technology Data Exchange (ETDEWEB)

    Sudarski, Sonja; Henzler, Thomas [Heidelberg Univ., Universitaetsmedizin Mannheim (Germany). Inst. fuer Klinische Radiologie und Nuklearmedizin

    2016-09-15

    Pulmonary embolism (PE) requires a quick diagnostic algorithm, as the untreated disease has a high mortality and morbidity. Crucial for the diagnostic assessment chosen is the initial clinical likelihood of PE and the individual risk profile of the patient. The overall goal is to diagnose or rule out PE as quickly and safely as possible or to initiate timely treatment if necessary. CT angiography of the pulmonary arteries (CTPA) with multi-slice CT scanner systems presents the actual diagnostic reference standard. With CTPA further important diagnoses can be made, like presence of right ventricular dysfunction. There are different scan and contrast application protocols that can be applied in order to gain diagnostic examinations with sufficient contrast material enhancement in the pulmonary arteries while avoiding all kinds of artifacts. This review article is meant to be a practical guide to examine patients with suspected PE according to the actual guidelines.

  1. Pulmonary manifestations of heartworm disease.

    Science.gov (United States)

    Calvert, C A; Rawlings, C A

    1985-09-01

    The clinical signs associated with heartworm disease are the result of changes in the pulmonary arterial system. These clinical signs are the result of either pulmonary hypertension or lung parenchymal disease associated with vascular changes. An increase in pulmonary arterial pressure produces an increase in right ventricular afterload, which may lead to exercise intolerance, syncope, and right-sided congestive heart failure. Coughing, dyspnea, and hemoptysis are the results of pulmonary parenchymal disease.

  2. Pulmonary artery sling: Case report

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Gil Hyun; Lee, Sun Wha; Cha, Sung Ho [Kyunghee University College of Medicine, Seoul (Korea, Republic of)

    1993-09-15

    Aberrant left-sided pulmonary artery(pulmonary artery sling) is an uncommon anomaly,which may cause significant respiratory abnormality. We report a case of pulmonary artery sling which is combined with persistent left superior vena cava and dextrocardia. This case were identified by esophagogram and CT and confirmed by MRI and angiography. We consider that MRI is a valuable new method for the diagnosis of aberrant left-sided pulmonary artery.

  3. Methamphetamine Use and Pulmonary Hypertension

    Science.gov (United States)

    ... other problems, diagnosing a case of pulmonary hyper- tension can be difficult and may require a specialist. Once pulmonary hyperten- sion is diagnosed, however, treatment can begin immediately. One form of PH is called pulmonary arterial hypertension (PAH). In PAH, the blood vessels that ...

  4. Pulmonary Artery Dissection: A Fatal Complication of Pulmonary Hypertension

    Directory of Open Access Journals (Sweden)

    Chuanchen Zhang

    2016-01-01

    Full Text Available Pulmonary artery dissection is extremely rare but it is a really life-threatening condition when it happens. Most patients die suddenly from major bleeding or tamponade caused by direct rupture into mediastinum or retrograde into the pericardial sac. What we are reporting is a rare case of a 46-year-old female patient whose pulmonary artery dissection involves both the pulmonary valve and right pulmonary artery. The patient had acute chest pain and severe dyspnea, and the diagnosis of pulmonary artery dissection was confirmed by ultrasonography and CT angiography. Moreover, its etiology, clinical manifestations, and management are also discussed in this article.

  5. Sound scattering in dense granular media

    Institute of Scientific and Technical Information of China (English)

    JIA XiaoPing; LAURENT J; KHIDAS Y; LANGLOIS V

    2009-01-01

    The sound propagation in a dense granular medium is basically characterized by the ratio of wave-length to the grain size. Two types of wave transport are distinguished: one corresponds to coherent waves in the long wavelength limit, the other to short-wavelength scattered waves by the inhomoge-neous contact force networks. These multiply scattered elastic waves are shown to exhibit a diffusive characteristics of transport over long distances of propagation. Determination of the transport mean free path l* and the inelastic absorption (Q~(-1)) allows the inference of the structural properties of the material such as the heterogeneity and internal dissipation. The relevance of our experiments for seismological applications is discussed. Moreover, we apply the correlation technique of the configu-ration-specific sound scattering to monitoring the dynamic behaviour of the granular medium (irre-versible rearrangements) under strong vibration, shearing and thermal cycling, respectively.

  6. Charmonium propagation through a dense medium

    Directory of Open Access Journals (Sweden)

    Kopeliovich B.Z.

    2015-01-01

    Full Text Available Attenuation of a colourless c̄c dipole propagating with a large momentum through a hot medium originates from two sources, Debye screening (melting, and inelastic collisions with surrounding scattering centres (absorption. The former never terminates completely production of a bound charmonium in heavy ion collisions, even at very high temperatures. The latter, is controlled my the magnitude of the dipole cross section, related to the transport coefficient, which is the rate of transverse momentum broadening in the medium. A novel procedure of Lorentz boosting of the Schrödinger equation is developed, which allows to calculate the charmonium survival probability employing the path-integral technique, incorporating both melting and absorption. A novel mechanism of charmonium regeneration in a dense medium is proposed.

  7. Intense, ultrashort light and dense, hot matter

    Indian Academy of Sciences (India)

    G Ravindra Kumar

    2009-07-01

    This article presents an overview of the physics and applications of the interaction of high intensity laser light with matter. It traces the crucial advances that have occurred over the past few decades in laser technology and nonlinear optics and then discusses physical phenomena that occur in intense laser fields and their modeling. After a description of the basic phenomena like multiphoton and tunneling ionization, the physics of plasma formed in dense matter is presented. Specific phenomena are chosen for illustration of the scientific and technological possibilities – simulation of astrophysical phenomena, relativistic nonlinear optics, laser wakefield acceleration, laser fusion, ultrafast real time X-ray diffraction, application of the particle beams produced from the plasma for medical therapies etc. A survey of the Indian activities in this research area appears at the end.

  8. Frontiers and challenges in warm dense matter

    CERN Document Server

    Desjarlais, Michael; Redmer, Ronald; Trickey, Samuel

    2014-01-01

    Warm Dense Matter (WDM) occupies a loosely defined region of phase space intermediate between solid, liquid, gas, and plasma, and typically shares characteristics of two or more of these phases. WDM is generally associated with the combination of strongly coupled ions and moderately degenerate electrons, and careful attention to quantum physics and electronic structure is essential. The lack of a small perturbation parameter greatly limits approximate attempts at its accurate description. Since WDM resides at the intersection of solid state and high energy density physics, many high energy density physics (HEDP) experiments pass through this difficult region of phase space. Thus, understanding and modeling WDM is key to the success of experiments on diverse facilities. These include the National Ignition Campaign centered on the National Ignition Facility (NIF), pulsed-power driven experiments on the Z machine, ion-beam-driven WDM experiments on the NDCX-II, and fundamental WDM research at the Linear Coherent...

  9. Evolution of Binaries in Dense Stellar Systems

    CERN Document Server

    Ivanova, Natalia

    2011-01-01

    In contrast to the field, the binaries in dense stellar systems are frequently not primordial, and could be either dynamically formed or significantly altered from their primordial states. Destruction and formation of binaries occur in parallel all the time. The destruction, which constantly removes soft binaries from a binary pool, works as an energy sink and could be a reason for cluster entering the binary-burning phase. The true binary fraction is greater than observed, as a result, the observable binary fraction evolves differently from the predictions. Combined measurements of binary fractions in globular clusters suggest that most of the clusters are still core-contracting. The formation, on other hand, affects most the more evolutionary advanced stars, which significantly enhances the population of X-ray sources in globular clusters. The formation of binaries with a compact objects proceeds mainly through physical collisions, binary-binary and single-binary encounters; however, it is the dynamical for...

  10. Carbon nitride frameworks and dense crystalline polymorphs

    Science.gov (United States)

    Pickard, Chris J.; Salamat, Ashkan; Bojdys, Michael J.; Needs, Richard J.; McMillan, Paul F.

    2016-09-01

    We used ab initio random structure searching (AIRSS) to investigate polymorphism in C3N4 carbon nitride as a function of pressure. Our calculations reveal new framework structures, including a particularly stable chiral polymorph of space group P 43212 containing mixed s p2 and s p3 bonding, that we have produced experimentally and recovered to ambient conditions. As pressure is increased a sequence of structures with fully s p3 -bonded C atoms and three-fold-coordinated N atoms is predicted, culminating in a dense P n m a phase above 250 GPa. Beyond 650 GPa we find that C3N4 becomes unstable to decomposition into diamond and pyrite-structured CN2.

  11. Plasmon resonance in warm dense matter

    Energy Technology Data Exchange (ETDEWEB)

    Thiele, R; Bornath, T; Fortmann, C; Holl, A; Redmer, R; Reinholz, H; Ropke, G; Wierling, A; Glenzer, S H; Gregori, G

    2008-02-21

    Collective Thomson scattering with extreme ultraviolet light or x-rays is shown to allow for a robust measurement of the free electron density in dense plasmas. Collective excitations like plasmons appear as maxima in the scattering signal. Their frequency position can directly be related to the free electron density. The range of applicability of the standard Gross-Bohm dispersion relation and of an improved dispersion relation in comparison to calculations based on the dielectric function in random phase approximation is investigated. More important, this well-established treatment of Thomson scattering on free electrons is generalized in the Born-Mermin approximation by including collisions. We show that, in the transition region from collective to non-collective scattering, the consideration of collisions is important.

  12. Properties of industrial dense gas plumes

    Science.gov (United States)

    Shaver, E. M.; Forney, L. J.

    Hazardous gases and vapors are often discharged into the atmosphere from industrial plants during catastrophic events (e.g. Union Carbide incident in Bhopal, India). In many cases the discharged components are more dense than air and settle to the ground surface downstream from the stack exit. In the present paper, the buoyant plume model of Hoult, Fay and Forney (1969, J. Air Pollut. Control Ass. 19, 585-590.) has been altered to predict the properties of hazardous discharges. In particular, the plume impingement point, radius and concentration are predicted for typical stack exit conditions, wind speeds and temperature profiles. Asymptotic expressions for plume properties at the impingement point are also derived for a constant crosswind and neutral temperature profile. These formulae are shown to be useful for all conditions.

  13. Constitutive relations for steady, dense granular flows

    Science.gov (United States)

    Vescovi, D.; Berzi, D.; di Prisco, C. G.

    2011-12-01

    In the recent past, the flow of dense granular materials has been the subject of many scientific works; this is due to the large number of natural phenomena involving solid particles flowing at high concentration (e.g., debris flows and landslides). In contrast with the flow of dilute granular media, where the energy is essentially dissipated in binary collisions, the flow of dense granular materials is characterized by multiple, long-lasting and frictional contacts among the particles. The work focuses on the mechanical response of dry granular materials under steady, simple shear conditions. In particular, the goal is to obtain a complete rheology able to describe the material behavior within the entire range of concentrations for which the flow can be considered dense. The total stress is assumed to be the linear sum of a frictional and a kinetic component. The frictional and the kinetic contribution are modeled in the context of the critical state theory [8, 10] and the kinetic theory of dense granular gases [1, 3, 7], respectively. In the critical state theory, the granular material approaches a certain attractor state, independent on the initial arrangement, characterized by the capability of developing unlimited shear strains without any change in the concentration. Given that a disordered granular packing exists only for a range of concentration between the random loose and close packing [11], a form for the concentration dependence of the frictional normal stress that makes the latter vanish at the random loose packing is defined. In the kinetic theory, the particles are assumed to interact through instantaneous, binary and uncorrelated collisions. A new state variable of the problem is introduced, the granular temperature, which accounts for the velocity fluctuations. The model has been extended to account for the decrease in the energy dissipation due to the existence of correlated motion among the particles [5, 6] and to deal with non

  14. Dense QCD: a Holographic Dyonic Salt

    CERN Document Server

    Rho, Mannque; Zahed, Ismail

    2009-01-01

    Dense QCD at zero temperature with a large number of colors is a crystal. We show that in the holographic dual description, the crystal is made out of pairs of dyons with $e=g=\\pm 1$ charges in a salt-like arrangement. We argue that with increasing density the dyon masses and topological charges equalize, turning the salt-like configuration to a bcc of half-instantons. The latter is dual to a cubic crystal of half-skyrmions. We estimate the transition from an fcc crystal of instantons to a bcc crystal of dyons to about 3 times nuclear matter density with a dyon binding energy of about 180 MeV.

  15. Dynamic structure of dense krypton gas

    Science.gov (United States)

    Egelstaff, P. A.; Salacuse, J. J.; Schommers, W.; Ram, J.

    1984-07-01

    We have made molecular-dynamics computer simulations of dense krypton gas (10.6×1027 atoms/m3 and 296 K) using reasonably realistic pair potentials. Comparisons are made with the recent experimental data[P. A. Egelstaff et al., Phys. Rev. A 27, 1106 (1983)] for the dynamic structure factor S(q,ω) over the range 0.4

  16. Extra-pulmonary Pneumocystis jiroveciinfection: a case report

    Directory of Open Access Journals (Sweden)

    Mehrdad Bakhshayesh Karam

    2014-12-01

    Full Text Available In physical examination abdominal tenderness, gate disturbance and penile herpetic lesions were detected. Decreased disc height at T11-T12 level was detected in chest X-ray. Abdominal sonography and CT scan revealed hypo dense lesions in Lt left Lobe of liver and multiple hypo dense splenic and pancreatic lesions, ascitis, Lt left sided pleural effusion, thickening of jejuneal mucosa and edema of bowel wall. Vertebral body lesion and paravertebral abscess, bony calvarial involvement and adjacent extra axial brain lesion were observed in imaging were other findings. RNA analysis for HIV was positive. Vertebral lesion biopsy and aspiration of splenic lesion were performed and pathology revealed Pneumocystis jirovecii suggestive of extra pulmonary Pneumocystis carinii infection.

  17. X-ray scattering from dense plasmas

    Energy Technology Data Exchange (ETDEWEB)

    McSherry, D.J

    2000-09-01

    Dense plasmas were studied by probing them with kilovolt x-rays and measuring those scattered at various angles. The Laser-Produced x-ray source emitted Ti He alpha 4.75 keV x-rays. Two different plasma types were explored. The first was created by laser driven shocks on either side of a sample foil consisting of 2 micron Al layer, sandwiched between two 1 micron CH layers. We have observed a peak in the x-ray scattering cross section, indicating diffraction from the plasma. However, the experimentally inferred plasma density, broadly speaking, did not always agree with the hydrodynamic simulation MEDX (A modified version of MEDUSA). The second plasma type that we studied was created by soft x-ray heating on either side of a sample foil, this time consisting of 1 micron layer of Al, sandwiched between two 0.2 micron CH layers. Two foil targets, each consisting of a 0.1 micron thick Au foil mounted on 1 micron of CH, where placed 4 mm from the sample foil. The soft x-rays where produced by laser irradiating these two foil targets. We found that, 0.5 ns after the peak of the laser heating pulses, the measured cross sections more closely matched those simulated using the Thomas Fermi model than the Inferno model. Later in time, at 2 ns, the plasma is approaching a weakly coupled state. This is the first time x-ray scattering cross sections have been measured from dense plasmas generated by radiatively heating both sides of the sample. Moreover, these are absolute values typically within a factor of two of expectation for early x-ray probe times. (author)

  18. X-ray scattering from dense plasmas

    Science.gov (United States)

    McSherry, Declan Joseph

    Dense plasmas were studied by probing them with kilovolt x-rays and measuring those scattered at various angles. The laser produced x-ray source emitted Ti He alpha 4.75 keV x-rays. Two different plasma types were explored. The first was created by laser driven shocks on either side of a sample foil consisting of 2 micron thickness of Al, sandwiched between two 1 micron CH layers. We have observed a peak in the x-ray scattering cross section, indicating diffraction from the plasma. However, the experimentally inferred plasma density, did not always agree broadly with the hydrodynamic simulation MEDX (A modified version of MEDUSA). The second plasma type that we studied was created by soft x-ray heating on either side of a sample foil, this time consisting of 1 micron thickness of Al, sandwiched between two 0.2 micron CH layers. Two foil targets, each consisting of a 0.1 micron thick Au foil mounted on 1 micron of CH, were placed 4 mm from the sample foil. The soft x-rays were produced by laser irradiating these two foil targets. We found that, 0.5 ns after the peak of the laser heating pulses, that the measured cross sections more closely matched those simulated using the Thomas Fermi model than the Inferno model. Later in time, at 2 ns, the plasma is approaching a weakly coupled state. This is the first time x-ray scattering cross sections have been measured from dense plasmas generated by radiatively heating both sides of the sample. Moreover, these are absolute values typically within a factor of two of expectation for early x-ray probe times.

  19. Dense gas dispersion in the atmosphere

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, Morten

    1998-09-01

    Dense gas dispersion is characterized by buoyancy induced gravity currents and reduction of the vertical mixing. Liquefied gas releases from industrial accidents are cold because of the heat of evaporation which determines the density for a given concentration and physical properties. The temperature deficit is moderated by the heat flux from the ground, and this convection is an additional source of turbulence which affects the mixing. A simple model as the soil heat flux is used to estimate the ability of the ground to sustain the heat flux during release. The initial enthalpy, release rate, initial entrainment and momentum are discussed for generic source types and the interaction with obstacles is considered. In the MTH project BA experiments source with and without momentum were applied. The continuously released propane gas passed a two-dimensional removable obstacle perpendicular to the wind direction. Ground-level gas concentrations and vertical profiles of concentration, temperature, wind speed and turbulence were measured in front of and behind the obstacle. Ultrasonic anemometers providing fast velocity and concentration signals were mounted at three levels on the masts. The observed turbulence was influenced by the stability and the initial momentum of the jet releases. Additional information were taken from the `Dessert tortoise` ammonia jet releases, from the `Fladis` experiment with transition from dense to passive dispersion, and from the `Thorney Island` continuous releases of isothermal freon mixtures. The heat flux was found to moderate the negative buoyancy in both the propane and ammonia experiments. The heat flux measurements are compared to an estimate by analogy with surface layer theory. (au) 41 tabs., 146 ills., 189 refs.

  20. Canine pulmonary angiostrongylosis

    DEFF Research Database (Denmark)

    Koch, Jørgen; Willesen, Jakob Lundgren

    2009-01-01

    Canine pulmonary angiostrongylosis is an emerging snail-borne disease causing verminous pnemonia and coagulopathy in dogs. The parasite is fund in Europe, North and South America and Africa, covering tropical, subtropical and temperate regions. Its distribution has been characterised by isolated ...

  1. Primary Pulmonary Hodgkin Lymphoma

    OpenAIRE

    Shumaila Tanveer; Ahmed El Damati; Ayman El Baz; Ahmed Alsayyah; Tarek ElSharkawy; Mohamed Regal

    2015-01-01

    Primary pulmonary Hodgkin lymphoma (PPHL) is a rare disease. Herein, we report a case of PPHL with diagnostic concerns encountered during initial evaluation which is of paramount importance to keep the differential diagnosis in cases with high index of sus- picion for this rare entity.

  2. Solitary pulmonary nodule

    Science.gov (United States)

    ... Chest x-ray Granulomatosis with polyangiitis Histoplasmosis Lung cancer - small cell Pulmonary tuberculosis Skin nodules Valley fever Review Date 8/1/2015 Updated by: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, ... Cancer Lung Diseases Browse the Encyclopedia A.D.A. ...

  3. An unexpected pulmonary bystander

    NARCIS (Netherlands)

    Wouthuyzen-Bakker, M.; Vorm, van der P. A.; Koning, K. J.; van der Werf, T. S.

    2016-01-01

    A 30-year-old man from Eritrea was admitted with a pulmonary bacterial abscess. Unexpectedly, histopathology of the resected lobe also revealed an infection with Schistosoma mansoni with surrounding granulomatous tissue and fibrosis. Patients from endemic areas are often asymptomatic with blood eosi

  4. What Is Pulmonary Hypertension?

    Science.gov (United States)

    ... Artery Disease Venous Thromboembolism Aortic Aneurysm More Pulmonary Hypertension - High Blood Pressure in the Heart-to-Lung System Updated:Sep ... Pressure" This content was last reviewed October 2016. High Blood Pressure • Home • Get the Facts About HBP Introduction What ...

  5. Pulmonary function tests

    Science.gov (United States)

    ... or lung disease. Some lung diseases (such as emphysema, asthma, chronic bronchitis, and infections) can make the lungs ... A.M. Editorial team. Related MedlinePlus Health Topics Asthma Breathing Problems COPD Emphysema Interstitial Lung Diseases Lung Diseases Pulmonary Fibrosis Sarcoidosis ...

  6. Hantavirus Pulmonary Syndrome

    Centers for Disease Control (CDC) Podcasts

    2011-07-14

    Dr. Adam MacNeil, epidemiologist with Viral Special Pathogens Branch at CDC, discusses hantavirus pulmonary syndrome.  Created: 7/14/2011 by National Center for Emerging Zoonotic and Infectious Diseases (NCEZID).   Date Released: 7/18/2011.

  7. Pathogenesis of pulmonary vasculitis

    NARCIS (Netherlands)

    Heeringa, P; Schreiber, A; Falk, RJ; Jennette, JC

    2004-01-01

    Vasculitis is inflammation of blood vessels and can affect any type of vessel in any organ. Pulmonary vasculitis usually is a component of a systemic small vessel vasculitis. Three major forms of small vessel vasculitis that often affect the lungs are Wegener's granulomatosis, microscopic polyangiit

  8. Idiopathic pulmonary fibrosis.

    Science.gov (United States)

    Xaubet, Antoni; Ancochea, Julio; Molina-Molina, María

    2017-02-23

    Idiopathic pulmonary fibrosis is a fibrosing interstitial pneumonia associated with the radiological and/or histological pattern of usual interstitial pneumonia. Its aetiology is unknown, but probably comprises the action of endogenous and exogenous micro-environmental factors in subjects with genetic predisposition. Its diagnosis is based on the presence of characteristic findings of high-resolution computed tomography scans and pulmonary biopsies in absence of interstitial lung diseases of other aetiologies. Its clinical evolution is variable, although the mean survival rate is 2-5 years as of its clinical presentation. Patients with idiopathic pulmonary fibrosis may present complications and comorbidities which modify the disease's clinical course and prognosis. In the mild-moderate disease, the treatment consists of the administration of anti-fibrotic drugs. In severe disease, the best therapeutic option is pulmonary transplantation. In this paper we review the diagnostic and therapeutic aspects of the disease. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  9. Pulmonary lobectomy - slideshow

    Science.gov (United States)

    ... ency/presentations/100094.htm Pulmonary lobectomy - series—Normal anatomy To use the sharing features on this page, please enable JavaScript. Go to slide 1 out of 3 Go to slide 2 out of 3 Go to slide 3 out of 3 Overview The lungs are comprised of lobes. The right lung has ...

  10. [Pulmonary involvements of sarcoidosis].

    Science.gov (United States)

    Ohmichi, M; Hiraga, Y; Hirasawa, M

    1990-01-01

    We reported about intrathoracic changes and prognosis of 686 patients with sarcoidosis diagnosed in our hospital between 1963 and 1988. We evaluated CT findings in 135 patients with sarcoidosis and found pulmonary involvements in 81. We analyzed CT findings according to the classification by Tuengerthal which classified radiographic findings combining ILO classification of pneumoconiosis and characteristic findings of bronchovascular sheath with sarcoidosis. The CT findings were as follows: small opacities (44 out of 81 cases, 54.3%), large opacities (37 cases, 46.7%). Additional findings were as follows: peribronchial marking (42 cases, 51.9%), contraction (17 cases, 21.0%), pleural involvement (9 cases, 11.1%), bulla (5 cases, 6.2%). The characteristic CT findings of serious sarcoidosis were extasis of bronchus, thickening of the bronchial wall, unclearness of vascular shadow, atelectasis and thickening of pleura. Concerning the prognosis of pulmonary involvement, according to age, patients younger than 30 years old at initial diagnosis were better than those of 30 years and over in terms of disappearance of pulmonary involvements. According to stage, patients of stage I and stage II were better than those of stage III. Among the patients we were able to observe chest X-ray findings during five years according to the character of shadow, ill-defined shadow of small opacities and rounded shadows of large opacities had a higher disappearance rate of pulmonary involvements than irregular shadows of large opacities, atelectasis and contraction.

  11. Pulmonary alveolar proteinosis

    Science.gov (United States)

    ... ray High-resolution CT scan of the chest Pulmonary function tests Open lung biopsy (surgical biopsy) Treatment Treatment involves washing out the protein substance from the lung (whole-lung lavage) from time to time. Some persons may need a lung ... References Levine SM. ...

  12. Unilateral pulmonary agenesis.

    Science.gov (United States)

    Malcon, Maura Cavada; Malcon, Claudio Mattar; Cavada, Marina Neves; Caruso, Paulo Eduardo Macedo; Real, Lara Flório

    2012-01-01

    Pulmonary agenesis is a rare congenital anomaly. We report the case of an 8-year-old boy with left lung agenesis, without any other congenital malformations. When the patient presented symptoms, including cough, wheezing, and dyspnea, with no clinical improvement after a period of 30 days, imaging studies were conducted and the diagnosis was made.

  13. Primary pulmonary hypertension.

    Science.gov (United States)

    Rashid, A; Lehrman, S; Romano, P; Frishman, W; Dobkin, J; Reichel, J

    2000-01-01

    Primary pulmonary hypertension (PPH) is a condition characterized by sustained elevation of pulmonary artery pressure (PAP) without demonstrable cause. The most common symptom at presentation is dyspnea. Other complaints include fatigue, chest pain, syncope, leg edema, and palpitations. Right heart catheterization is diagnostic, showing a mean PAP >25 mmHg at rest and >30 mmHg during exercise, with a normal pulmonary capillary wedge pressure. In the National Institutes of Health-PPH registry, the median survival period was 2.8 years. Treatment is aimed at lowering PAP, increasing cardiac output, and decreasing in situ thrombosis. Vasodilators have been used with some success in the treatment of PPH. They include prostacyclin, calcium-channel blockers, nitric oxide and adenosine. Anticoagulation has also been advised for the prevention of deep vein thrombosis, pulmonary embolism, and in situ thromboses of the lungs. New drug treatments under investigation include L-arginine, plasma endothelin-I, and bosentan. Use of oxygen, digoxin, and diuretics for symptomatic relief have also been recommended. Patients with severe PPH refractory to medical management should be considered for surgery.

  14. Pathogenesis of pulmonary vasculitis

    NARCIS (Netherlands)

    Heeringa, P; Schreiber, A; Falk, RJ; Jennette, JC

    2004-01-01

    Vasculitis is inflammation of blood vessels and can affect any type of vessel in any organ. Pulmonary vasculitis usually is a component of a systemic small vessel vasculitis. Three major forms of small vessel vasculitis that often affect the lungs are Wegener's granulomatosis, microscopic

  15. Pulmonary langerhans cell histiocytosis

    Directory of Open Access Journals (Sweden)

    Suri Harpreet S

    2012-03-01

    Full Text Available Abstract Pulmonary Langerhans Cell Histiocytosis (PLCH is a relatively uncommon lung disease that generally, but not invariably, occurs in cigarette smokers. The pathologic hallmark of PLCH is the accumulation of Langerhans and other inflammatory cells in small airways, resulting in the formation of nodular inflammatory lesions. While the overwhelming majority of patients are smokers, mechanisms by which smoking induces this disease are not known, but likely involve a combination of events resulting in enhanced recruitment and activation of Langerhans cells in small airways. Bronchiolar inflammation may be accompanied by variable lung interstitial and vascular involvement. While cellular inflammation is prominent in early disease, more advanced stages are characterized by cystic lung destruction, cicatricial scarring of airways, and pulmonary vascular remodeling. Pulmonary function is frequently abnormal at presentation. Imaging of the chest with high resolution chest CT scanning may show characteristic nodular and cystic abnormalities. Lung biopsy is necessary for a definitive diagnosis, although may not be required in instances were imaging findings are highly characteristic. There is no general consensus regarding the role of immunosuppressive therapy in smokers with PLCH. All smokers must be counseled on the importance of smoking cessation, which may result in regression of disease and obviate the need for systemic immunosuppressive therapy. The prognosis for most patients is relatively good, particularly if longitudinal lung function testing shows stability. Complications like pneumothoraces and secondary pulmonary hypertension may shorten life expectancy. Patients with progressive disease may require lung transplantation.

  16. Three cases of pulmonary varix

    Energy Technology Data Exchange (ETDEWEB)

    Takishima, Teruo; Sakuma, Hajime; Tajima, Tsunemi; Okimoto, Takao; Yamamoto, Keiichiro; Dohi, Yutaka (Saitama Medical School (Japan))

    1982-06-01

    Three cases of pulmonary varix associated with valvular heart disease were reported. Round shadows were clearer on first oblique or lateral films of chest x-ray in all 3 cases. On chest tomograms, the shadows were substantial and round-elliptical. RI angiography with sup(99m)Tc-RBC demonstrated these shadows in agreement with the site of influx of the pulmonary vein into the left atrium in Cases 1 and 3 and with the pulmonary vein slightly apart from the left atrium in Case 2. On CT scans in Cases 1 and 3, enhancement with a contrast medium visualized dilatation of the pulmonary vein close to, and in continuation with, the shadow of the left atrium. The diagnosis of pulmonary varix in agreement with the venous phase of pulmonary angiography was made for all 3 cases. Non-surgical examinations (especially CT scan) proved highly useful for the diagnosis of pulmonary varix.

  17. Breast cancer screening in Korean woman with dense breast tissue

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Hee Jung [Dept. of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul (Korea, Republic of); Ko, Eun Sook [Dept. of Radiology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul (Korea, Republic of); Yi, Ann [Dept. of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul (Korea, Republic of)

    2015-11-15

    Asian women, including Korean, have a relatively higher incidence of dense breast tissue, compared with western women. Dense breast tissue has a lower sensitivity for the detection of breast cancer and a higher relative risk for breast cancer, compared with fatty breast tissue. Thus, there were limitations in the mammographic screening for women with dense breast tissue, and many studies for the supplemental screening methods. This review included appropriate screening methods for Korean women with dense breasts. We also reviewed the application and limitation of supplemental screening methods, including breast ultrasound, digital breast tomosynthesis, and breast magnetic resonance imaging; and furthermore investigated the guidelines, as well as the study results.

  18. meta-DENSE complex acquisition for reduced intravoxel dephasing

    Science.gov (United States)

    Aletras, Anthony H.; Arai, Andrew E.

    2004-08-01

    Displacement encoding with stimulated echoes (DENSE) with a meta-DENSE readout and RF phase cycling to suppress the STEAM anti-echo is described for reducing intravoxel dephasing signal loss. This RF phase cycling scheme, when combined with existing meta-DENSE suppression of the T1 recovering signal, yields higher quality DENSE myocardial strain maps. Phantom and human images are provided to demonstrate the technique, which is capable of acquiring phase contrast displacement encoded images at low encoding gradient strengths providing better spatial resolution and less signal loss due to intravoxel dephasing than prior methods.

  19. Molecular imaging of the human pulmonary vascular endothelium in pulmonary hypertension: a phase II safety and proof of principle trial

    Energy Technology Data Exchange (ETDEWEB)

    Harel, Francois [Montreal Heart Institute, Research Center, Montreal, QC (Canada); Universite de Montreal, Department of Nuclear Medicine, Montreal, Quebec (Canada); Langleben, David; Abikhzer, Gad [McGill University, Lady Davis Institute and Jewish General Hospital, Montreal, Quebec (Canada); Provencher, Steve; Guimond, Jean [Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec (Canada); Fournier, Alain; Letourneau, Myriam [INRS-Institut Armand-Frappier, Laval, Quebec (Canada); Finnerty, Vincent; Nguyen, Quang T.; Levac, Xavier [Montreal Heart Institute, Research Center, Montreal, QC (Canada); Mansour, Asmaa; Guertin, Marie-Claude [Montreal Health Innovation Coordination Center, Montreal, QC (Canada); Dupuis, Jocelyn [Montreal Heart Institute, Research Center, Montreal, QC (Canada); Universite de Montreal, Department of Medicine, Montreal, Quebec (Canada)

    2017-07-15

    The adrenomedullin receptor is densely expressed in the pulmonary vascular endothelium. PulmoBind, an adrenomedullin receptor ligand, was developed for molecular diagnosis of pulmonary vascular disease. We evaluated the safety of PulmoBind SPECT imaging and its capacity to detect pulmonary vascular disease associated with pulmonary hypertension (PH) in a human phase II study. Thirty patients with pulmonary arterial hypertension (PAH, n = 23) or chronic thromboembolic PH (CTEPH, n = 7) in WHO functional class II (n = 26) or III (n = 4) were compared to 15 healthy controls. Lung SPECT was performed after injection of 15 mCi {sup 99m}Tc-PulmoBind in supine position. Qualitative and semi-quantitative analyses of lung uptake were performed. Reproducibility of repeated testing was evaluated in controls after 1 month. PulmoBind injection was well tolerated without any serious adverse event. Imaging was markedly abnormal in PH with ∝50% of subjects showing moderate to severe heterogeneity of moderate to severe extent. The abnormalities were unevenly distributed between the right and left lungs as well as within each lung. Segmental defects compatible with pulmonary embolism were present in 7/7 subjects with CTEPH and in 2/23 subjects with PAH. There were no segmental defects in controls. The PulmoBind activity distribution index, a parameter indicative of heterogeneity, was elevated in PH (65% ± 28%) vs. controls (41% ± 13%, p = 0.0003). In the only subject with vasodilator-responsive idiopathic PAH, PulmoBind lung SPECT was completely normal. Repeated testing 1 month later in healthy controls was well tolerated and showed no significant variability of PulmoBind distribution. In this phase II study, molecular SPECT imaging of the pulmonary vascular endothelium using {sup 99m}Tc-PulmoBind was safe. PulmoBind showed potential to detect both pulmonary embolism and abnormalities indicative of pulmonary vascular disease in PAH. Phase III studies with this novel tracer and

  20. Pulmonary Thromboendarterectomy for Pulmonary Hypertension Before Considering Transplant

    Science.gov (United States)

    Kooperkamp, Hannah; Mehta, Inder; Fary, David; Bates, Michael

    2017-01-01

    Background: In cases of chronic thromboembolic pulmonary hypertension (CTEPH), referral for possible surgical intervention is important because surgery can be curative. Surgery necessitates cardiopulmonary bypass and deep circulatory arrest with pulmonary thrombectomy and bilateral endarterectomy (PTE). If surgery fails, lung transplant is the next best surgical option. Medical treatment is also an important adjunct. Case Report: A 35-year-old female presented 3 months after a pulmonary embolus was found to be completely occluding her left pulmonary artery. She was found to have pulmonary hypertension with a pulmonary artery pressure of 81/33 mmHg, with a mean pressure of 52 mmHg. The right atrial pressure was also severely elevated at 29 mmHg, and her echocardiogram revealed severe tricuspid regurgitation and severe right ventricular dysfunction. She underwent PTE and postoperatively was followed by the heart failure team. Her 6-minute walk distance improved from 396 meters at 1 month to 670 meters at 7 months, and her pulmonary artery pressure improved significantly to 55/17 mmHg with a mean pressure of 31 mmHg. The patient's right atrial pressure also improved significantly from 29 mmHg to 13 mmHg. Conclusion: CTEPH is likely underrecognized, and patients with pulmonary hypertension or a history of pulmonary embolism should be screened for CTEPH. This case illustrates the surgical treatment for CTEPH and discusses alternative and adjunctive treatments. Residual pulmonary hypertension after PTE occurs in approximately 35% of patients. Overall, 4-year mortality rates after surgery appear to be approximately 15%, and mortality rates correlate with the postoperative pulmonary vascular resistance. Recognition of chronic pulmonary thromboembolic disease as the etiology of pulmonary hypertension warrants evaluation for surgery.

  1. Pulmonary arterial hypertension

    Science.gov (United States)

    2013-01-01

    Pulmonary arterial hypertension (PAH) is a chronic and progressive disease leading to right heart failure and ultimately death if untreated. The first classification of PH was proposed in 1973. In 2008, the fourth World Symposium on PH held in Dana Point (California, USA) revised previous classifications. Currently, PH is devided into five subgroups. Group 1 includes patients suffering from idiopathic or familial PAH with or without germline mutations. Patients with a diagnosis of PAH should systematically been screened regarding to underlying mutations of BMPR2 gene (bone morphogenetic protein receptor type 2) or more rarely of ACVRL1 (activine receptor-like kinase type 1), ENG (endogline) or Smad8 genes. Pulmonary veno occusive disease and pulmonary capillary hemagiomatosis are individualized and designated as clinical group 1'. Group 2 'Pulmonary hypertension due to left heart diseases' is divided into three sub-groups: systolic dysfonction, diastolic dysfonction and valvular dysfonction. Group 3 'Pulmonary hypertension due to respiratory diseases' includes a heterogenous subgroup of respiratory diseases like PH due to pulmonary fibrosis, COPD, lung emphysema or interstitial lung disease for exemple. Group 4 includes chronic thromboembolic pulmonary hypertension without any distinction of proximal or distal forms. Group 5 regroup PH patients with unclear multifactorial mechanisms. Invasive hemodynamic assessment with right heart catheterization is requested to confirm the definite diagnosis of PH showing a resting mean pulmonary artery pressure (mPAP) of ≥ 25 mmHg and a normal pulmonary capillary wedge pressure (PCWP) of ≤ 15 mmHg. The assessment of PCWP may allow the distinction between pre-capillary and post-capillary PH (PCWP > 15 mmHg). Echocardiography is an important tool in the management of patients with underlying suspicion of PH. The European Society of Cardiology and the European Respiratory Society (ESC-ERS) guidelines specify its role

  2. Dense Molecular Cores Being Externally Heated

    CERN Document Server

    Kim, Gwanjeong; Gopinathan, Maheswar; Jeong, Woong-Seob; Kim, Mi-Ryang

    2016-01-01

    We present results of our study on eight dense cores, previously classified as starless, using infrared (3-160 {\\micron}) imaging observations with \\textit{AKARI} telescope and molecular line (HCN and N$_2$H$^+$) mapping observations with \\textit{KVN} telescope. Combining our results with the archival IR to mm continuum data, we examined the starless nature of these eight cores. Two of the eight cores are found to harbor faint protostars having luminosity of $\\sim0.3-4.4$ L$_{\\odot}$. The other six cores are found to remain as starless and probably are in a dynamically transitional state. The temperature maps produced using multi-wavelength images show an enhancement of about 3-6 K towards the outer boundary of these cores, suggesting that they are most likely being heated externally by nearby stars and/or interstellar radiation fields. Large virial parameters and an over-dominance of red asymmetric line profiles over the cores may indicate that the cores are set into either an expansion or an oscillatory mot...

  3. The ionization fraction in dense clouds

    CERN Document Server

    De Boisanger, C B; Van Dishoeck, E F

    1995-01-01

    We present submillimeter observations of various molecular ions toward two dense clouds, NGC 2264 IRS1 and W 3 IRS5, in order to investigate their ionization fraction. Analysis of the line intensity ratios by the way of statistical equilibrium calculations allows determination of the physical parameters: n(H2)~(1-2)e6 cm-3 and T(kin)~50-100 K. Column densities and abundances are also derived. Together, the abundances of the observed ions provide a lower limit to the ionization fraction, which is (2-3)e-9 in both clouds. In order to better constrain the electron abundance, a simple chemical model is built which calculates the steady state abundances of the major positive ions, using the observed abundances wherever available. With reasonable assumptions, good agreement within a factor of two with the observations can be achieved. The calculated electron fraction is x(e)= (1.0-3.3)e-8 in the case of NGC 2264 and x(e)=(0.5-1.1)e-8 for W 3 IRS5. In the first case, the high abundance of N2H+ requires a rather high...

  4. Elemental nitrogen partitioning in dense interstellar clouds

    CERN Document Server

    Daranlot, Julien; Bergeat, Astrid; Costes, Michel; Loison, Jean-Christophe; Wakelam, Valentine; Hickson, Kevin M

    2012-01-01

    Many chemical models of dense interstellar clouds predict that the majority of gas-phase elemental nitrogen should be present as N2, with an abundance approximately five orders of magnitude less than that of hydrogen. As a homonuclear diatomic molecule, N2 is difficult to detect spectroscopically through infrared or millimetre-wavelength transitions so its abundance is often inferred indirectly through its reaction product N2H+. Two main formation mechanisms each involving two radical-radical reactions are the source of N2 in such environments. Here we report measurements of the low temperature rate constants for one of these processes, the N + CN reaction down to 56 K. The effect of the measured rate constants for this reaction and those recently determined for two other reactions implicated in N2 formation are tested using a gas-grain model employing a critically evaluated chemical network. We show that the amount of interstellar nitrogen present as N2 depends on the competition between its gas-phase format...

  5. Kinetic Simulations of Dense Plasma Focus Breakdown

    Science.gov (United States)

    Schmidt, A.; Higginson, D. P.; Jiang, S.; Link, A.; Povilus, A.; Sears, J.; Bennett, N.; Rose, D. V.; Welch, D. R.

    2015-11-01

    A dense plasma focus (DPF) device is a type of plasma gun that drives current through a set of coaxial electrodes to assemble gas inside the device and then implode that gas on axis to form a Z-pinch. This implosion drives hydrodynamic and kinetic instabilities that generate strong electric fields, which produces a short intense pulse of x-rays, high-energy (>100 keV) electrons and ions, and (in deuterium gas) neutrons. A strong factor in pinch performance is the initial breakdown and ionization of the gas along the insulator surface separating the two electrodes. The smoothness and isotropy of this ionized sheath are imprinted on the current sheath that travels along the electrodes, thus making it an important portion of the DPF to both understand and optimize. Here we use kinetic simulations in the Particle-in-cell code LSP to model the breakdown. Simulations are initiated with neutral gas and the breakdown modeled self-consistently as driven by a charged capacitor system. We also investigate novel geometries for the insulator and electrodes to attempt to control the electric field profile. The initial ionization fraction of gas is explored computationally to gauge possible advantages of pre-ionization which could be created experimentally via lasers or a glow-discharge. Prepared by LLNL under Contract DE-AC52-07NA27344.

  6. Order and instabilities in dense bacterial colonies

    Science.gov (United States)

    Tsimring, Lev

    2012-02-01

    The structure of cell colonies is governed by the interplay of many physical and biological factors, ranging from properties of surrounding media to cell-cell communication and gene expression in individual cells. The biomechanical interactions arising from the growth and division of individual cells in confined environments are ubiquitous, yet little work has focused on this fundamental aspect of colony formation. By combining experimental observations of growing monolayers of non-motile strain of bacteria Escherichia coli in a shallow microfluidic chemostat with discrete-element simulations and continuous theory, we demonstrate that expansion of a dense colony leads to rapid orientational alignment of rod-like cells. However, in larger colonies, anisotropic compression may lead to buckling instability which breaks perfect nematic order. Furthermore, we found that in shallow cavities feedback between cell growth and mobility in a confined environment leads to a novel cell streaming instability. Joint work with W. Mather, D. Volfson, O. Mondrag'on-Palomino, T. Danino, S. Cookson, and J. Hasty (UCSD) and D. Boyer, S. Orozco-Fuentes (UNAM, Mexico).

  7. Current practice for pulmonary hypertension

    Institute of Scientific and Technical Information of China (English)

    Toru Satoh

    2014-01-01

    Objective To investigate the current practice of pulmonary hypertension including current epidemiology,diagnosis and treatment.Data sources The review was based on data obtained from the published articles and guidelines.Study selection Articles with high level of evidence or current best evidence in each issue were selected to be reviewed.Results Overall prevalence of pulmonary hypertension was 0.3% to 6% with left heart disease occupying the most proportion,followed by pulmonary disease,pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.In diagnosis,a flow diagram of diagnosis of pulmonary hypertension,differential diagnosis of pulmonary hypertension and how to determine the severity of pulmonary hypertension are explained including recent development of magnetic resonance imaging and gene abnormality study on bone morphogenetic protein receptor Ⅱ.In treatment,newlydeveloped pulmonary vasodilators and the way to use them are shown to treat pulmonary hypertension.Conclusion Safer and more effective treatment algorithm and basic researches and clinical trials are warranted to be explored.

  8. Pulmonary manifestations of the antiphospholipid antibody syndrome.

    Science.gov (United States)

    Ford, H James; Roubey, Robert A S

    2010-09-01

    A broad spectrum of pulmonary disease may occur in antiphospholipid antibody syndrome. The most common pulmonary manifestations are pulmonary thromboembolism and pulmonary hypertension. In this article the authors review these manifestations, as well as less common findings including acute respiratory distress syndrome, alveolar hemorrhage, and pulmonary capillaritis.

  9. Pulmonary endarterectomy outputs in chronic thromboembolic pulmonary hypertension.

    Science.gov (United States)

    López Gude, María Jesús; Pérez de la Sota, Enrique; Pérez Vela, Jose Luís; Centeno Rodríguez, Jorge; Muñoz Guijosa, Christian; Velázquez, María Teresa; Alonso Chaterina, Sergio; Hernández González, Ignacio; Escribano Subías, Pilar; Cortina Romero, José María

    2017-07-07

    Pulmonary thromboendarterectomy surgery is the treatment of choice for patients with chronic thromboembolic pulmonary hypertension; extremely high pulmonary vascular resistance constitutes a risk factor for hospital mortality. The objective of this study was to analyze the immediate and long-term results of the surgical treatment of chronic thromboembolic pulmonary hypertension in patients with very severe pulmonary hypertension. Since February 1996, we performed 160 pulmonary thromboendarterectomies. We divided the patient population in 2 groups: group 1, which included 40 patients with pulmonary vascular resistance≥1090dyn/sec/cm(-5), and group 2, which included the remaining 120 patients. Hospital mortality (15 vs. 2.5%), reperfusion pulmonary edema (33 vs. 14%) and heart failure (23 vs. 3.3%) were all higher in group 1; however, after one year of follow-up, there were no significant differences in the clinical, hemodynamic and echocardiographic conditions of both groups. Survival rate after 5 years was 77% in group 1 and 92% in group 2 (P=.033). After the learning curve including the 46 first patients, there was no difference in hospital mortality (3.8 vs. 2.3%) or survival rate after 5 years (96.2% in group 1 and 96.2% in group 2). Pulmonary thromboendarterectomy is linked to significantly higher morbidity and mortality rates in patients with severe chronic thromboembolic pulmonary hypertension. Nevertheless, these patients benefit the same from the procedure in the mid-/long-term. In our experience, after the learning curve, this surgery is safe in severe pulmonary hypertension and no level of pulmonary vascular resistance should be an absolute counter-indication for this surgery. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  10. Persistent diffuse pulmonary interstitial emphysema mimicking pulmonary emphysema

    OpenAIRE

    Demura, Y.; Ishizaki, T; Nakanishi, M; Ameshima, S; Itoh, H.

    2009-01-01

    A 69-year-old male non-smoker with a history of atopic asthma presented with symptoms suggestive of chronic obstructive pulmonary disease and this appeared to be corroborated by lung function testing and a chest radiograph. However, a chest CT showed no evidence of pulmonary emphysema and instead demonstrated free air along the bronchovascular sheaths indicative of pulmonary interstistial emphysema, possibly caused by repeated prior exacerbations of asthma. His lung function tests and symptom...

  11. Pulmonary Strongyloidiasis Masquerading as Exacerbation of Chronic Obstructive Pulmonary Disease

    Science.gov (United States)

    Pradhan, Gourahari; Behera, Priyadarshini; Bhuniya, Sourin; Mohapatra, Prasanta Raghab; Turuk, Jyotirmayee; Mohanty, Srujana

    2016-01-01

    Pulmonary strongyloidiasis is an uncommon presentation of Strongyloides infection, usually seen in immunocompromised hosts. The manifestations are similar to that of acute exacerbation of chronic obstructive pulmonary disease (COPD). Therefore, the diagnosis of pulmonary strongyloidiasis could be challenging in a COPD patient, unless a high index of suspicion is maintained. Here, we present a case of Strongyloides hyperinfection in a COPD patient mimicking acute exacerbation, who was on chronic steroid therapy. PMID:27790284

  12. Permutation Matrix Method for Dense Coding Using GHZ States

    Institute of Scientific and Technical Information of China (English)

    JIN Rui-Bo; CHEN Li-Bing; WANG Fa-Qiang; SU Zhi-Kun

    2008-01-01

    We present a new method called the permutation matrix method to perform dense coding using Greenberger-Horne-Zeilinger (GHZ) states. We show that this method makes the study of dense coding systematically and regularly. It also has high potential to be realized physically.

  13. Mining connected global and local dense subgraphs for bigdata

    Science.gov (United States)

    Wu, Bo; Shen, Haiying

    2016-01-01

    The problem of discovering connected dense subgraphs of natural graphs is important in data analysis. Discovering dense subgraphs that do not contain denser subgraphs or are not contained in denser subgraphs (called significant dense subgraphs) is also critical for wide-ranging applications. In spite of many works on discovering dense subgraphs, there are no algorithms that can guarantee the connectivity of the returned subgraphs or discover significant dense subgraphs. Hence, in this paper, we define two subgraph discovery problems to discover connected and significant dense subgraphs, propose polynomial-time algorithms and theoretically prove their validity. We also propose an algorithm to further improve the time and space efficiency of our basic algorithm for discovering significant dense subgraphs in big data by taking advantage of the unique features of large natural graphs. In the experiments, we use massive natural graphs to evaluate our algorithms in comparison with previous algorithms. The experimental results show the effectiveness of our algorithms for the two problems and their efficiency. This work is also the first that reveals the physical significance of significant dense subgraphs in natural graphs from different domains.

  14. Phase Structure and Transport Properties of Dense Quark Matter

    CERN Document Server

    Schaefer, Thomas

    2010-01-01

    We provide a summary of our current knowledge of the phase structure of very dense quark matter. We concentrate on the question how the ground state at asymptotically high density -- color-flavor-locked (CFL) matter -- is modified as the density is lowered. We discuss the nature of the quasi-particle excitations, and present work on the transport properties of dense QCD matter.

  15. Finding dense locations in symbolic indoor tracking data

    DEFF Research Database (Denmark)

    Ahmed, Tanvir; Pedersen, Torben Bach; Lu, Hua

    2017-01-01

    Finding the dense locations in large indoor spaces is very useful for many applications such as overloaded area detection, security control, crowd management, indoor navigation, and so on. Indoor tracking data can be enormous and are not immediately ready for finding dense locations. This paper...

  16. Pulmonary sarcoidosis: management.

    Directory of Open Access Journals (Sweden)

    Sharma O

    2002-04-01

    Full Text Available During the last two decades many advances have been made in the field of sarcoidosis. The disease is now recognised as a multisystem disorder occurring in patients with a genetic predisposition and an exposure to yet unknown transmissible environmental agent/s. The diagnosis is based on a compatible clinical and/or radiological picture, histological evidence of non-caseating granuloma and exclusion of other diseases capable of producing a similar clinical or histological picture. Treatment primarily consists of administration of corticosteroids, although there are valuable alternative drugs. Treatment should be considered in symptomatic patients with evidence of radiologic or lung function deterioration. The patients with extra-pulmonary involvement particularly with ocular, myocardial, and neuro-sarcoidosis almost always need treatment. For asymptomatic pulmonary sarcoidosis patients no therapy is needed.

  17. Update in pulmonary medicine.

    Science.gov (United States)

    Marks, John H

    2013-04-01

    Pulmonary disorders are common and important causes of morbidity and even mortality in adolescents. Conditions that are considered in this article include asthma, cystic fibrosis, and vocal cord dysfunction. Chronic and recurrent exacerbations may occur in youth with such disorders; therefore, they must adhere to potentially many pharmacologic agents and therapeutic procedures on a regular basis for maximum medical and psychosocial outcomes. It is important that physicians use au courant evidence-based guidelines in the management of adolescents. It is also critical that physicians educate adolescents about these regimens to help them maximize management outcomes. If disease control is inadequate, referral to a pulmonary specialist can be helpful to verify the correct diagnosis(es) and ensure that the most appropriate therapies are used.

  18. Pulmonary interstitial glycogenosis

    Energy Technology Data Exchange (ETDEWEB)

    Lanfranchi, Michael [Creighton University Medical School, Children' s Hospital and Medical Center, Omaha, NE (United States); Allbery, Sandra M.; Wheelock, Lisa [Children' s Hospital and Medical Center, Department of Radiology, Omaha, NE (United States); Perry, Deborah [Children' s Hospital and Medical Center, Department of Pathology, Omaha, NE (United States)

    2010-03-15

    Although bronchopulmonary dysplasia (BPD) is a common cause of interstitial lung disease in chronically intubated premature neonates, other interstitial lung disease in nonintubated infants is rare. We present a case of pulmonary interstitial glycogenosis that developed in a nonintubated, 31-week gestation infant in whom infectious etiologies had been excluded. The infant was well initially and then developed respiratory distress at 18 days of life. Radiographs at first day of life were normal, but CT and radiographic findings at 18 days of life showed severe interstitial lung disease, mimicking BPD. Lung biopsy showed pulmonary interstitial glycogenosis. This entity is not well described in the pediatric radiology literature and is important to consider, as the condition is responsive to a course of corticosteroids. (orig.)

  19. "Vanishing" pulmonary valve stenosis

    Directory of Open Access Journals (Sweden)

    Nofil I Arain

    2012-01-01

    Full Text Available Objective: Both spontaneous resolution and progression of mild pulmonary valve stenosis (PS have been reported. We reviewed characteristics of the pulmonary valve (PV to determine factors that could influence resolution of mild PS. Methods: Fifteen asymptomatic pediatric patients with spontaneous resolution of isolated mild PS were retrospectively reviewed. Results: There was no correlation between the PV gradient, clinical presentation, age at diagnosis, or PV morphology. The PV annulus was small at initial presentation, which normalized at follow up. When corrected for the body surface area (z-score, the PV annulus was normal in all patients, including at initial evaluation. Conclusions: Based on our observation, neither age at diagnosis, nor PV-morphology-influenced resolution of mild PS. The variable clinical presentation makes it difficult to categorize and observe mild PS by auscultation alone. The PV annulus z-score could be a useful adjunct to determine the course and serial observation of mild PS.

  20. Multislice computed tomography perfusion imaging for visualization of acute pulmonary embolism: animal experience

    Energy Technology Data Exchange (ETDEWEB)

    Wildberger, Joachim Ernst; Spuentrup, Elmar; Mahnken, Andreas H.; Guenther, Rolf W. [University Hospital, RWTH Aachen, Department of Diagnostic Radiology, Aachen (Germany); Klotz, Ernst; Ditt, Hendrik [Computed Tomography, Siemens Medical Solutions, Forchheim (Germany)

    2005-07-01

    deficits indicating PE on the color-coded enhancement display. Subtraction was feasible for all seven studies. In one animal, opacification of the pulmonary arteries was suboptimal owing to heart insufficiency. In the remaining six pigs, a total of 37 perfusion defects were clearly assessable downstream of occluded subsegmental arteries, showing lower or missing enhancement compared with normally perfused lung parenchyma. Indeterminate findings from CTA showed typical PE perfusion defects in four out of six cases on CT subtraction. Additionally, 22 peripheral triangular-shaped enhancement defects were delineated. Nine of these findings were reclassified as definitely being caused by PE on second reading of the CTA data sets. Our initial results have shown that this new subtraction technique for perfusion imaging of PE is feasible, using routine contrast delivery. Dedicated examination protocols are mandatory for adequate opacification of the pulmonary arteries and for optimization of data sets for subsequent subtraction. (orig.)

  1. Balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension

    Directory of Open Access Journals (Sweden)

    Irene Lang

    2017-03-01

    Full Text Available Chronic thromboembolic pulmonary hypertension (CTEPH is thought to result from incomplete resolution of pulmonary thromboemboli that undergo organisation into fibrous tissue within pulmonary arterial branches, filling pulmonary arterial lumina with collagenous obstructions. The treatment of choice is pulmonary endarterectomy (PEA in CTEPH centres, which has low post-operative mortality and good long-term survival. For patients ineligible for PEA or who have recurrent or persistent pulmonary hypertension after surgery, medical treatment with riociguat is beneficial. In addition, percutaneous balloon pulmonary angioplasty (BPA is an emerging option, and promises haemodynamic and functional benefits for inoperable patients. In contrast to conventional angioplasty, BPA with undersized balloons over guide wires exclusively breaks intraluminal webs and bands, without dissecting medial vessel layers, and repeat sessions are generally required. Observational studies report that BPA improves haemodynamics, symptoms and functional capacity in patients with CTEPH, but controlled trials with long-term follow-up are needed. Complications include haemoptysis, wire injury, vessel dissection, vessel rupture, reperfusion pulmonary oedema, pulmonary parenchymal bleeding and haemorrhagic pleural effusions. This review summarises the available evidence for BPA, patient selection, recent technical refinements and periprocedural imaging, and discusses the potential future role of BPA in the management of CTEPH.

  2. Isolated Pulmonary Valve Endocarditis

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Hatamizadeh

    2009-06-01

    Full Text Available Infective endocarditis is one of the most severe complications of parenteral drug abuse. The outstanding clinical feature of infective endocarditis in intravenous drug abusers is the high incidence of right-sided valve infection, and the tricuspid valve is involved in 60% to 70% of the cases. We herein report a case of isolated pulmonic valve infective endocarditis with a native pulmonary valve.

  3. Pulmonary trichomoniasis and Trichomonas tenax.

    Science.gov (United States)

    Hersh, S M

    1985-08-01

    Pulmonary trichomoniasis is usually caused by aspirated Trichomonas tenax. Adult men with chronic purulent or necrotic pulmonary disease are usually affected. Sixty-eight patients were previously described. A Russian study demonstrated pulmonary trichomoniasis in 19 of 112 patients (17%), mostly in patients with lung cancer, lung abscess, or bronchiectasis. Rarely, pulmonary trichomoniasis may be caused by an intra-abdominal (T. hominis) or genitourinary (T. vaginalis) infection. T. tenax is usually regarded as a harmless commensal of the human mouth. Its prevalence ranges from 4% to 53% and may exceed that of vaginal infection with T. vaginalis in adult females. It is frequently found in patients with poor oral hygiene. Cultural identification is superior to microscopic examination of wet-smear, gram-stained and Papanicolaou-stained preparations. Aspirated pulmonary trichomoniasis is an opportunistic infection. Until the question of possible pathogenicity is resolved, metronidazole should be given. The underlying pulmonary disease should be vigorously treated.

  4. Graphle: Interactive exploration of large, dense graphs

    Directory of Open Access Journals (Sweden)

    Huttenhower Curtis

    2009-12-01

    Full Text Available Abstract Background A wide variety of biological data can be modeled as network structures, including experimental results (e.g. protein-protein interactions, computational predictions (e.g. functional interaction networks, or curated structures (e.g. the Gene Ontology. While several tools exist for visualizing large graphs at a global level or small graphs in detail, previous systems have generally not allowed interactive analysis of dense networks containing thousands of vertices at a level of detail useful for biologists. Investigators often wish to explore specific portions of such networks from a detailed, gene-specific perspective, and balancing this requirement with the networks' large size, complex structure, and rich metadata is a substantial computational challenge. Results Graphle is an online interface to large collections of arbitrary undirected, weighted graphs, each possibly containing tens of thousands of vertices (e.g. genes and hundreds of millions of edges (e.g. interactions. These are stored on a centralized server and accessed efficiently through an interactive Java applet. The Graphle applet allows a user to examine specific portions of a graph, retrieving the relevant neighborhood around a set of query vertices (genes. This neighborhood can then be refined and modified interactively, and the results can be saved either as publication-quality images or as raw data for further analysis. The Graphle web site currently includes several hundred biological networks representing predicted functional relationships from three heterogeneous data integration systems: S. cerevisiae data from bioPIXIE, E. coli data using MEFIT, and H. sapiens data from HEFalMp. Conclusions Graphle serves as a search and visualization engine for biological networks, which can be managed locally (simplifying collaborative data sharing and investigated remotely. The Graphle framework is freely downloadable and easily installed on new servers, allowing any

  5. Dense surface reconstruction with shadows in MIS.

    Science.gov (United States)

    Lin, Bingxiong; Sun, Yu; Qian, Xiaoning

    2013-09-01

    Three-dimensional reconstruction of internal organ surfaces provides useful information for better control and guidance of the operations of surgical tools for minimally invasive surgery (MIS). The current reconstruction techniques using stereo cameras are still challenging due to the difficulties in correspondence matching in MIS, since there is very limited texture but significant specular reflection on organ surfaces. This paper proposes a new approach to overcome the problem by introducing weakly structured light actively casting surgical tool shadows on organ surfaces. The contribution of this paper is twofold: first, we propose a robust approach to extract shadow edges from a sequence of shadowed images; second, we develop a novel field surface interpolation (FSI) approach to obtain an accurate and dense disparity map. Our approach does not rely on texture information and is able to reconstruct accurate 3-D information by exploiting shadows from surgical tools. One advantage is that the point correspondences are directly calculated and no explicit stereo matching is required, which ensures the efficiency of the method. Another advantage is the minimum hardware requirement because only stereo cameras and a separated single-point light source are required. We evaluated the proposed approach using both phantom models and ex vivo images. Based on the experimental results, we achieved the precision of the recovered 3-D surfaces within 0.7 mm for phantom models and 1.2 mm for ex vivo images. The comparison of disparity maps indicates that with the addition of shadows, the proposed method significantly outperforms the state-of-the-art stereo algorithms for MIS.

  6. Pulmonary edema: radiographic differential diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Dong Soo; Choi, Young Hi; Kim, Seung Cheol; An, Ji Hyun; Lee, Jee Young; Park, Hee Hong [Dankook Univ. College of Medicine, Chonan (Korea, Republic of)

    1997-04-01

    To evaluate the feasibility of using chest radiography to differentiate between three different etiologies of pulmonary edema. Plain chest radiographs of 77 patients, who were clinically confirmed as having pulmonary edema, were retrospectively reviewed. The patients were classified into three groups : group 1 (cardiogenic edema : n = 35), group 2 (renal pulmonary edema : n = 16) and group 3 (permeability edema : n = 26). We analyzed the radiologic findings of air bronchogram, heart size, peribronchial cuffing, septal line, pleural effusion, vascular pedicle width, pulmonary blood flow distribution and distribution of pulmonary edema. In a search for radiologic findings which would help in the differentiation of these three etiologies, each finding was assessed. Cardiogenic and renal pulmonary edema showed overlapping radiologic findings, except for pulmonary blood flow distribution. In cardiogenic pulmonary edema (n=35), cardiomegaly (n=29), peribronchial cuffing (n=29), inverted pulmonary blood flow distribution (n=21) and basal distribution of edema (n=20) were common. In renal pulmonary edema (n=16), cardiomegaly (n=15), balanced blood flow distribution (n=12), and central (n=9) or basal distribution of edema (n=7) were common. Permeability edema (n=26) showed different findings. Air bronchogram (n=25), normal blood flow distribution (n=14) and peripheral distribution of edema (n=21) were frequent findings, while cardiomegaly (n=7), peribronchial cuffing (n=7) and septal line (n=5) were observed in only a few cases. On plain chest radiograph, permeability edema can be differentiated from cardiogenic or renal pulmonary edema. The radiographic findings which most reliably differentiated these two etiologies were air bronchogram, distribution of pulmonary edema, peribronchial cuffing and heart size. Only blood flow distribution was useful for radiographic differentiation of cardiogenic and renal edema.

  7. Ablative Approaches for Pulmonary Metastases.

    Science.gov (United States)

    Boyer, Matthew J; Ricardi, Umberto; Ball, David; Salama, Joseph K

    2016-02-01

    Pulmonary metastases are common in patients with cancer for which surgery is considered a standard approach in appropriately selected patients. A number of patients are not candidates for surgery due to a medical comorbidities or the extent of surgery required. For these patients, noninvasive or minimally invasive approaches to ablate pulmonary metastases are potential treatment strategies. This article summarizes the rationale and outcomes for non-surgical treatment approaches, including radiotherapy, radiofrequency and microwave ablation, for pulmonary metastases.

  8. Pulmonary alterations in cocaine users

    Directory of Open Access Journals (Sweden)

    Mário Terra Filho

    Full Text Available CONTEXT: Brazilian researchers have recently recognized a marked increase in the number of people using abusable drugs and the consequences of this habit. It has become a major public health problem in a potentially productive segment of the general population. In the last few years, several medical articles have given special emphasis to pulmonary complications related to cocaine use. This review is based on this information and experience acquired with groups of cocaine users. OBJECTIVE: To present to physicians the pulmonary aspects of cocaine use and warn about the various effects this drug has on the respiratory system, stressing those related to long-term use. DESIGN: Narrative review. METHOD: Pulmonary complications are described. These may include infections (Staphylococcus aureus, pulmonary tuberculosis, acquired immunodeficiency syndrome/aids, etc., aspiration pneumonia, lung abscess, empyema, septic embolism, non-cardiogenic pulmonary edema, barotrauma, pulmonary granulomatosis, bronchiolitis obliterans and organizing pneumonia, pneumonitis and interstitial fibrosis, pneumonitis hypersensitivity, lung infiltrates and eosinophilia in individuals with bronchial hyperreactivity, diffuse alveolar hemorrhage, vasculitis, pulmonary infarction, pulmonary hypertension and alterations in gas exchange. It is concluded that physicians should give special attention to the various pulmonary and clinical manifestations related to cocaine use, particularly in young patients.

  9. Varicosity of the pulmonary veins

    Energy Technology Data Exchange (ETDEWEB)

    Leicher-Dueber, A.; Lindner, P.; Schild, H.; Plewe, G.

    1986-04-01

    Varicosity of the pulmonary veins is a rare anomaly of the pulmonary vascular system. The varices do not usually change in size over years, do not cause symptoms and need no therapy. However, raised left atrial pressure can cause increase in the diameter of pulmonary vein varices. A case of lung vein varicosity in the right middle and upper lobe associated with coarctation of the aorta and an anomalous upper-middle lobe vein was observed over a period of 10 years. Increase in left atrial pressure (aortic and relative mitral regurgitation) led to enlargement of the pulmonary veins.

  10. Prenatal prediction of pulmonary hypoplasia.

    Science.gov (United States)

    Triebwasser, Jourdan E; Treadwell, Marjorie C

    2017-03-15

    Pulmonary hypoplasia, although rare, is associated with significant neonatal morbidity and mortality. Conditions associated with pulmonary hypoplasia include those which limit normal thoracic capacity or movement, including skeletal dysplasias and abdominal wall defects; those with mass effect, including congenital diaphragmatic hernia and pleural effusions; and those with decreased amniotic fluid, including preterm, premature rupture of membranes, and genitourinary anomalies. The ability to predict severe pulmonary hypoplasia prenatally aids in family counseling, as well as obstetric and neonatal management. The objective of this review is to outline the imaging techniques that are widely used prenatally to assess pulmonary hypoplasia and to discuss the limitations of these methods.

  11. Multimodality imaging of pulmonary infarction

    Energy Technology Data Exchange (ETDEWEB)

    Bray, T.J.P., E-mail: timothyjpbray@gmail.com [Department of Radiology, Papworth Hospital NHS Foundation Trust, Ermine Street, Papworth Everard, Cambridge CB23 3RE (United Kingdom); Mortensen, K.H., E-mail: mortensen@doctors.org.uk [Department of Radiology, Papworth Hospital NHS Foundation Trust, Ermine Street, Papworth Everard, Cambridge CB23 3RE (United Kingdom); University Department of Radiology, Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Box 318, Cambridge CB2 0QQ (United Kingdom); Gopalan, D., E-mail: deepa.gopalan@btopenworld.com [Department of Radiology, Papworth Hospital NHS Foundation Trust, Ermine Street, Papworth Everard, Cambridge CB23 3RE (United Kingdom)

    2014-12-15

    Highlights: • A plethora of pulmonary and systemic disorders, often associated with grave outcomes, may cause pulmonary infarction. • A stereotypical infarct is a peripheral wedge shaped pleurally based opacity but imaging findings can be highly variable. • Multimodality imaging is key to diagnosing the presence, aetiology and complications of pulmonary infarction. • Multimodality imaging of pulmonary infarction together with any ancillary features often guide to early targeted treatment. • CT remains the principal imaging modality with MRI increasingly used alongside nuclear medicine studies and ultrasound. - Abstract: The impact of absent pulmonary arterial and venous flow on the pulmonary parenchyma depends on a host of factors. These include location of the occlusive insult, the speed at which the occlusion develops and the ability of the normal dual arterial supply to compensate through increased bronchial arterial flow. Pulmonary infarction occurs when oxygenation is cut off secondary to sudden occlusion with lack of recruitment of the dual supply arterial system. Thromboembolic disease is the commonest cause of such an insult but a whole range of disease processes intrinsic and extrinsic to the pulmonary arterial and venous lumen may also result in infarcts. Recognition of the presence of infarction can be challenging as imaging manifestations often differ from the classically described wedge shaped defect and a number of weighty causes need consideration. This review highlights aetiologies and imaging appearances of pulmonary infarction, utilising cases to illustrate the essential role of a multimodality imaging approach in order to arrive at the appropriate diagnosis.

  12. Systemic and Pulmonary Vascular Remodelling in Chronic Obstructive Pulmonary Disease.

    Directory of Open Access Journals (Sweden)

    Mariana Muñoz-Esquerre

    Full Text Available Chronic Obstructive Pulmonary Disease (COPD is associated with subclinical systemic atherosclerosis and pulmonary vascular remodelling characterized by intimal hyperplasia and luminal narrowing. We aimed to determine differences in the intimal thickening of systemic and pulmonary arteries in COPD subjects and smokers. Secondary aims include comparisons with a non-smokers group; determining the clinical variables associated with systemic and pulmonary intimal thickening, and the correlations between systemic and pulmonary remodelling changes.All consecutive subjects undergoing lung resection were included and divided into 3 groups: 1 COPD, 2 smokers, and 3 non-smokers. Sections of the 5th intercostal artery and muscular pulmonary arteries were measured by histo-morphometry. Four parameters of intimal thickening were evaluated: 1 percentage of intimal area (%IA, 2 percentage of luminal narrowing, 3 intimal thickness index, and 4 intima-to-media ratio.In the adjusted analysis, the systemic arteries of COPD subjects showed greater intimal thickening (%IA than those of smokers (15.6±1.5% vs. 14.2±1.6%, p = 0.038. In the pulmonary arteries, significant differences were observed for %IA between the 2 groups (37.3±2.2% vs. 29.3±2.3%, p = 0.016. Among clinical factors, metabolic syndrome, gender and COPD status were associated with the systemic intimal thickening, while only COPD status was associated with pulmonary intimal thickening. A correlation between the %IA of the systemic and pulmonary arteries was observed (Spearman's rho = 0.46, p = 0.008.Greater intimal thickening in systemic and pulmonary arteries is observed in COPD patients than in smokers. There is a correlation between systemic and pulmonary vascular remodelling in the overall population.

  13. Genetics Home Reference: pulmonary arterial hypertension

    Science.gov (United States)

    ... Home Health Conditions pulmonary arterial hypertension pulmonary arterial hypertension Enable Javascript to view the expand/collapse boxes. ... PDF Open All Close All Description Pulmonary arterial hypertension is a progressive disorder characterized by abnormally high ...

  14. Finding Hierarchical and Overlapping Dense Subgraphs using Nucleus Decompositions

    Energy Technology Data Exchange (ETDEWEB)

    Seshadhri, Comandur [The Ohio State Univ., Columbus, OH (United States); Pinar, Ali [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sariyuce, Ahmet Erdem [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Catalyurek, Umit [The Ohio State Univ., Columbus, OH (United States)

    2014-11-01

    Finding dense substructures in a graph is a fundamental graph mining operation, with applications in bioinformatics, social networks, and visualization to name a few. Yet most standard formulations of this problem (like clique, quasiclique, k-densest subgraph) are NP-hard. Furthermore, the goal is rarely to nd the \\true optimum", but to identify many (if not all) dense substructures, understand their distribution in the graph, and ideally determine a hierarchical structure among them. Current dense subgraph nding algorithms usually optimize some objective, and only nd a few such subgraphs without providing any hierarchy. It is also not clear how to account for overlaps in dense substructures. We de ne the nucleus decomposition of a graph, which represents the graph as a forest of nuclei. Each nucleus is a subgraph where smaller cliques are present in many larger cliques. The forest of nuclei is a hierarchy by containment, where the edge density increases as we proceed towards leaf nuclei. Sibling nuclei can have limited intersections, which allows for discovery of overlapping dense subgraphs. With the right parameters, the nuclear decomposition generalizes the classic notions of k-cores and k-trusses. We give provable e cient algorithms for nuclear decompositions, and empirically evaluate their behavior in a variety of real graphs. The tree of nuclei consistently gives a global, hierarchical snapshot of dense substructures, and outputs dense subgraphs of higher quality than other state-of-theart solutions. Our algorithm can process graphs with tens of millions of edges in less than an hour.

  15. HNCO in massive galactic dense cores

    Science.gov (United States)

    Zinchenko, I.; Henkel, C.; Mao, R. Q.

    2000-09-01

    We surveyed 81 dense molecular cores associated with regions of massive star formation and Sgr A in the JK-1K-1 = 505-404 and 10010-909 lines of HNCO. Line emission was detected towards 57 objects. Selected subsamples were also observed in the 101-000, 404-303, 707-606, 15015-14014, 16016-15015 and 21021-20020 lines, covering a frequency range from 22 to 461 GHz. HNCO lines from the K-1 = 2,3 ladders were detected in several sources. Towards Orion-KL, K-1 = 5 transitions with upper state energies Eu/k ~ 1100 and 1300 K could be observed. Five HNCO cores were mapped. The sources remain spatially unresolved at 220 and 461 GHz (10010-909 and 21010-20020 transitions) with beam sizes of 24'' and 18\\arcsec, respectively. The detection of hyperfine structure in the 101-000 transition is consistent with optically thin emission under conditions of Local Thermodynamic Equilibrium (LTE). This is corroborated by a rotational diagram analysis of Orion-KL that indicates optically thin line emission also for transitions between higher excited states. At the same time a tentative detection of interstellar HN13CO (the 100,10-90,9 line at 220 GHz toward G 310.12-0.20) suggests optically thick emission from some rotational transitions. Typical HNCO abundances relative to H2 as derived from a population diagram analysis are ~ 10-9. The rotational temperatures reach ~ 500 K. The gas densities in regions of HNCO K-1=0 emission should be n>~ 106 cm-3 and in regions of K-1>0 emission about an order of magnitude higher even for radiative excitation. HNCO abundances are found to be enhanced in high-velocity gas. HNCO integrated line intensities correlate well with those of thermal SiO emission. This indicates a spatial coexistence of the two species and may hint at a common production mechanism, presumably based on shock chemistry. Based on the observations collected at the European Southern Observatory, La Silla, Chile and on observations with the Heinrich-Hertz-Telescope (HHT). The HHT

  16. SUPPORTED DENSE CERAMIC MEMBRANES FOR OXYGEN SEPARATION

    Energy Technology Data Exchange (ETDEWEB)

    Timothy L. Ward

    2000-06-30

    . This successfully reduced cracking, however the films retained open porosity. The investigation of this concept will be continued in the final year of the project. Investigation of a metal organic chemical vapor deposition (MOCVD) method for defect mending in dense membranes was also initiated. An appropriate metal organic precursor (iron tetramethylheptanedionate) was identified whose deposition can be controlled by access to oxygen at temperatures in the 280-300 C range. Initial experiments have deposited iron oxide, but only on the membrane surface; thus refinement of this method will continue.

  17. Neutrino reactions in hot and dense matter

    Energy Technology Data Exchange (ETDEWEB)

    Lohs, Andreas

    2015-04-13

    In this thesis, neutrino reactions in hot and dense matter are studied. In particular, this work is concerned with neutrino-matter interactions that are relevant for neutrino transport in core-collapse supernovae (CCSNe). The majority of the energy from a CCSN is released in the form of neutrinos. Accurate understanding and computation of these interactions is most relevant to achieve sufficiently reliable predictions for the evolution of CCSNe and other related question such as the production of heavy elements or neutrino oscillations. For this purpose this work follows the combined approach of searching for new important neutrino reactions and improving the computation of those reactions that are already implemented. First we estimate the relevance of charged-current weak interactions that include muon-neutrinos or muons, as well as the role of neutron decay for neutrino transport in CCSNe. All of these reactions were previously neglected in CCSN-simulations. We derive and compute the matrix element and subsequent semi-analytic expressions for transport properties like the inverse mean free path of the new reactions. It is found that these reactions are important for muon neutrinos and low energy electron antineutrinos at very high densities in the protoneutron star surface. Consequently their implementation might lead to several changes in the prediction of CCSNe signatures such as the nucleosynthesis yields. Second we improve the precision in the computation of well known neutrino-nucleon reactions like neutrino absorption on neutrons. We derive semi-analytic expressions for transport properties that use less restrictive approximations while keeping the computational demand constant. Therefore we consider the full relativistic kinematics of all participating particles i.e. allowing for relativistic nucleons and finite lepton masses. Also the weak magnetism terms of the matrix elements are explicitly included to all orders. From our results we suggest that the

  18. Pulmonary mycoses among the clinically suspected cases of pulmonary tuberculosis

    Directory of Open Access Journals (Sweden)

    Tshering Ongmu Bhutia

    2015-01-01

    Full Text Available Background: This study was carried with the main objectives: (1 to find out the occurrence of pulmonary mycoses in clinically suspected pulmonary tuberculosis cases at central referral hospital, Tadong, Sikkim. (2 To find out the various fungi causing pulmonary mycoses in clinically suspected pulmonary tuberculosis cases. Methods: 200 clinically suspected pulmonary tuberculosis cases who visited the department of microbiology for the diagnostic microscopic examination of sputum sample for acid fast bacilli were included in this cross sectional study, carried out under the department of microbiology, Sikkim Manipal institute of medical sciences, over one year. Smears of sputum samples were examined microscopically for acid fast bacilli and fungal elements. Sputum samples were also plated onto different fungal culture media. Results: Out of 200 patients, various types of pathogens were detected in 54 (27% patients. Fourteen (7% patients were positive only for AFB, while fungus as a primary etiological agent was detected in 16(8% patients. Fungus as a secondary etiological agent was detected in 4 (2% patients [AFB with fungus in 2 (1%, AFB with fungus and bacteria in 1 (0.5% and bacteria with fungus in 1 (0.5% patient]. Conclusion: Pulmonary mycosis can be a primary infection in non- tuberculosis cases or co-infection in pulmonary tuberculosis cases. Investigation for fungal cause in clinically suspected cases of pulmonary tuberculosis will prevent misdiagnosis and mistreatment of cases. [Int J Res Med Sci 2015; 3(1.000: 260-268

  19. Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension.

    Science.gov (United States)

    Bryant, Andrew J; Carrick, Ryan P; McConaha, Melinda E; Jones, Brittany R; Shay, Sheila D; Moore, Christy S; Blackwell, Thomas R; Gladson, Santhi; Penner, Niki L; Burman, Ankita; Tanjore, Harikrishna; Hemnes, Anna R; Karwandyar, Ayub K; Polosukhin, Vasiliy V; Talati, Megha A; Dong, Hui-Jia; Gleaves, Linda A; Carrier, Erica J; Gaskill, Christa; Scott, Edward W; Majka, Susan M; Fessel, Joshua P; Haase, Volker H; West, James D; Blackwell, Timothy S; Lawson, William E

    2016-02-01

    Pulmonary hypertension (PH) complicating chronic parenchymal lung disease, such as idiopathic pulmonary fibrosis, results in significant morbidity and mortality. Since the hypoxia-inducible factor (HIF) signaling pathway is important for development of pulmonary hypertension in chronic hypoxia, we investigated whether HIF signaling in vascular endothelium regulates development of PH related to pulmonary fibrosis. We generated a transgenic model in which HIF is deleted within vascular endothelial cells and then exposed these mice to chronic intraperitoneal bleomycin to induce PH associated with lung fibrosis. Although no differences in the degree of fibrotic remodeling were observed, we found that endothelial HIF-deficient mice were protected against development of PH, including right ventricle and pulmonary vessel remodeling. Similarly, endothelial HIF-deficient mice were protected from PH after a 4-wk exposure to normobaric hypoxia. In vitro studies of pulmonary vascular endothelial cells isolated from the HIF-targeted mice and controls revealed that endothelial HIF signaling increases endothelial cell expression of connective tissue growth factor, enhances vascular permeability, and promotes pulmonary artery smooth muscle cell proliferation and wound healing ability, all of which have the potential to impact the development of PH in vivo. Taken together, these studies demonstrate that vascular endothelial cell HIF signaling is necessary for development of hypoxia and pulmonary fibrosis associated PH. As such, HIF and HIF-regulated targets represent a therapeutic target in these conditions.

  20. Tropical pulmonary eosinophilia presenting as severe pulmonary arterial hypertension

    Directory of Open Access Journals (Sweden)

    Shikha Jindal

    2013-01-01

    Full Text Available Tropical pulmonary eosinophilia (TPE is an easily diagnosed and treatable disease. Patients with TPE usually present with respiratory symptoms that include paroxysmal cough, breathlessness, wheeze and chest pain, often misdiagnosed as bronchial asthma. This case highlights one of the unusual presentations of TPE and discusses the association between TPE and pulmonary hypertension.

  1. Fatal dissection of the pulmonary artery in pulmonary arterial hypertension

    Directory of Open Access Journals (Sweden)

    B. Degano

    2009-09-01

    Full Text Available A 41-yr-old patient with chronic stable idiopathic pulmonary arterial hypertension (PAH presented with sudden chest pain and unusual dyspnoea during physical exertion. The patient had been diagnosed with PAH at the age of 12 yrs and was in New York Heart Association functional class I/II. The patient was being treated with an anticoagulant regimen, low-dose diuretics and continuous intravenous epoprostenol therapy. A computed tomography scan showed ancient massive thrombi in dilated central pulmonary arteries, which were not haemodynamically significant (perfusion lung scans did not demonstrate segmental or larger defects, and extensive dissection of the right pulmonary artery starting from the intermediate branch. Due to the extensiveness of the dissection, the patient was immediately considered for heart–lung transplantation, but died 72 h after the onset of symptoms. Permission for post mortem examination was denied. Pulmonary artery dissection should be suspected in PAH patients presenting with chest pain and worsening dyspnoea. In the current case, the factors possibly associated with increased risk for dissection may include dilatation of the pulmonary artery, local inflammation favoured by in situ thrombosis, and acute increase of pulmonary pressure secondary to physical exertion. Extensive pulmonary artery dissection is a life-threatening complication of PAH, and urgent heart/lung transplantation might be the treatment of choice in eligible patients. In addition, better identification of the risk factors for pulmonary artery dissection may help in considering transplantation for selected patients at risk.

  2. Pulmonary MRA: Differentiation of pulmonary embolism from truncation artefact

    Energy Technology Data Exchange (ETDEWEB)

    Bannas, Peter [University of Wisconsin-Madison, Department of Radiology, Madison, WI (United States); University Hospital Hamburg-Eppendorf, Department of Radiology, Hamburg (Germany); Schiebler, Mark L.; Motosugi, Utaroh; Francois, Christopher J. [University of Wisconsin-Madison, Department of Radiology, Madison, WI (United States); Reeder, Scott B. [University of Wisconsin-Madison, Department of Radiology, Madison, WI (United States); University of Wisconsin-Madison, Department of Biomedical Engineering, Madison, WI (United States); University of Wisconsin-Madison, Department of Medical Physics, Madison, WI (United States); University of Wisconsin-Madison, Department of Medicine, Madison, WI (United States); Nagle, Scott K. [University of Wisconsin-Madison, Department of Radiology, Madison, WI (United States); University of Wisconsin-Madison, Department of Medical Physics, Madison, WI (United States); University of Wisconsin-Madison, Department of Pediatrics, Madison, WI (United States)

    2014-08-15

    Truncation artefact (Gibbs ringing) causes central signal drop within vessels in pulmonary magnetic resonance angiography (MRA) that can be mistaken for emboli, reducing diagnostic accuracy for pulmonary embolism (PE). We propose a quantitative approach to differentiate truncation artefact from PE. Twenty-eight patients who underwent pulmonary computed tomography angiography (CTA) for suspected PE were recruited for pulmonary MRA. Signal intensity drops within pulmonary arteries that persisted on both arterial-phase and delayed-phase MRA were identified. The percent signal loss between the vessel lumen and central drop was measured. CTA served as the reference standard for presence of pulmonary emboli. A total of 65 signal intensity drops were identified on MRA. Of these, 48 (74 %) were artefacts and 17 (26 %) were PE, as confirmed by CTA. Truncation artefacts had a significantly lower median signal drop than PE on both arterial-phase (26 % [range 12-58 %] vs. 85 % [range 53-91 %]) and delayed-phase MRA (26 % [range 11-55 %] vs. 77 % [range 47-89 %]), p < 0.0001 for both. Receiver operating characteristic (ROC) analyses revealed a threshold value of 51 % (arterial phase) and 47 % signal drop (delayed phase) to differentiate between truncation artefact and PE with 100 % sensitivity and greater than 90 % specificity. Quantitative signal drop is an objective tool to help differentiate truncation artefact and pulmonary embolism in pulmonary MRA. (orig.)

  3. Detailed statistical analysis plan for the pulmonary protection trial

    DEFF Research Database (Denmark)

    Buggeskov, Katrine B; Jakobsen, Janus C; Secher, Niels H

    2014-01-01

    BACKGROUND: Pulmonary dysfunction complicates cardiac surgery that includes cardiopulmonary bypass. The pulmonary protection trial evaluates effect of pulmonary perfusion on pulmonary function in patients suffering from chronic obstructive pulmonary disease. This paper presents the statistical plan...

  4. The Key Technique of Manufacture of Dense Chromium Sesquioxide Refractories

    Institute of Scientific and Technical Information of China (English)

    LIMaoqiang; ZHANGShuying; 等

    1998-01-01

    Dense chromium sesquioxide refractories have widely been used in the kilns for making alkai-free and anti-alkali glass fibers due to their excellent re-sistance to molten glasses.Densifications of chromium sesquioxide during sintering can be blocked by evaporation of chromium trioxide derived from oxidation at high temperature,In this paper the mech-anism of sintering chromium oxide and the process-ing technique for making dense chromium sesquiox-ide refractories are discussed .A process in laboratory scale for making dense chromium sesquioxide bricks is demonstrated.

  5. Dense deposit disease in a child with febrile sore throat

    Directory of Open Access Journals (Sweden)

    Giovanni Conti

    2017-01-01

    Full Text Available Dense deposit disease or membranoproliferative glomerulonephritis type II is a rare glomerulopathy characterized on renal biopsy by deposition of abnormal electron-dense material in the glomerular basement membrane. The pathophysiologic basis is uncontrolled systemic activation of the alternate pathway of the complement cascade. C3 nephritic factor, an autoantibody directed against the C3 convertase of the alternate pathway, plays a key role. In some patients, complement gene mutations have been identified. We report the case of a child who had persistent microscopic hematuria, proteinuria, and hypocomplementemia C3 for over 2 months. Renal biopsy confirmed the diagnosis of dense deposit disease.

  6. [Efferent innervation of pulmonary blood vessels and bronchi in rat (an immunohistochemical study)].

    Science.gov (United States)

    Chumasov, E I; Voronchikhin, P A; Korzhevskiĭ, D É

    2012-01-01

    In this investigation the peculiarities of innervation of bronchi and blood vessels of the lung were studied in 20 rats using immunohistochemical demonstration of synaptophysin and alpha-actin. The results obtained have showen that the densest innervation is typical for bronchial walls, particularly, for the muscular lamina. Synaptophysin-immunoreactive terminals (SFIT) were detected in the bronchi in close association with both circular bundles of smooth muscle cells and microganglia. Dense network of SFIT was found in the pulmonary vein--in its middle tunic formed by cardiomyocytes. In contrast to the bronchi and pulmonary vein, large branches of the pulmonary artery contained no SFIT. We briefly discuss the problem of the origin of the nerve fibers described and their functions and suggest that SFIT are formed by efferent fibers (axons) of neurons arising from either the intrapulmonary parasympathetic ganglia.

  7. Chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    V K Vijayan

    2013-01-01

    Full Text Available The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD in adults aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. Pathological changes in COPD are observed in central airways, small airways and alveolar space. The proposed pathogenesis of COPD includes proteinase-antiproteinase hypothesis, immunological mechanisms, oxidant-antioxidant balance, systemic inflammation, apoptosis and ineffective repair. Airflow limitation in COPD is defined as a postbronchodilator FEV1 (forced expiratory volume in 1 sec to FVC (forced vital capacity ratio <0.70. COPD is characterized by an accelerated decline in FEV1. Co morbidities associated with COPD are cardiovascular disorders (coronary artery disease and chronic heart failure, hypertension, metabolic diseases (diabetes mellitus, metabolic syndrome and obesity, bone disease (osteoporosis and osteopenia, stroke, lung cancer, cachexia, skeletal muscle weakness, anaemia, depression and cognitive decline. The assessment of COPD is required to determine the severity of the disease, its impact on the health status and the risk of future events (e.g., exacerbations, hospital admissions or death and this is essential to guide therapy. COPD is treated with inhaled bronchodilators, inhaled corticosteroids, oral theophylline and oral phosphodiesterase-4 inhibitor. Non pharmacological treatment of COPD includes smoking cessation, pulmonary rehabilitation and nutritional support. Lung volume reduction surgery and lung transplantation are advised in selected severe patients. Global strategy for the diagnosis, management and prevention of Chronic Obstructive Pulmonary Disease

  8. Chronic obstructive pulmonary disease.

    Science.gov (United States)

    Vijayan, V K

    2013-02-01

    The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD) in adults aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. Pathological changes in COPD are observed in central airways, small airways and alveolar space. The proposed pathogenesis of COPD includes proteinase-antiproteinase hypothesis, immunological mechanisms, oxidant-antioxidant balance, systemic inflammation, apoptosis and ineffective repair. Airflow limitation in COPD is defined as a postbronchodilator FEV1 (forced expiratory volume in 1 sec) to FVC (forced vital capacity) ratio disease and chronic heart failure), hypertension, metabolic diseases (diabetes mellitus, metabolic syndrome and obesity), bone disease (osteoporosis and osteopenia), stroke, lung cancer, cachexia, skeletal muscle weakness, anaemia, depression and cognitive decline. The assessment of COPD is required to determine the severity of the disease, its impact on the health status and the risk of future events (e.g., exacerbations, hospital admissions or death) and this is essential to guide therapy. COPD is treated with inhaled bronchodilators, inhaled corticosteroids, oral theophylline and oral phosphodiesterase-4 inhibitor. Non pharmacological treatment of COPD includes smoking cessation, pulmonary rehabilitation and nutritional support. Lung volume reduction surgery and lung transplantation are advised in selected severe patients. Global strategy for the diagnosis, management and prevention of Chronic Obstructive Pulmonary Disease guidelines recommend influenza and pneumococcal vaccinations.

  9. Pulmonary arterial wall distensibility assessed by intravascular ultrasound in children with congenital heart disease : an indicator for pulmonary vascular disease?

    NARCIS (Netherlands)

    Berger, Rolf M F; Cromme-Dijkhuis, Adri H; Hop, Wim C J; Kruit, Marco N; Hess, John; Berger, Rudolphus

    2002-01-01

    BACKGROUND: Both pulmonary hypertension and pulmonary overflow are associated with functional and structural changes of the pulmonary arterial wall. Current techniques to evaluate the pulmonary vasculature neglect the pulsatile nature of pulmonary flow. STUDY OBJECTIVES: To determine whether the dyn

  10. Secuestro pulmonar Pulmonary sequestration

    Directory of Open Access Journals (Sweden)

    José Antonio Hernández Varea

    2010-06-01

    Full Text Available El secuestro pulmonar es una afección congénita que consiste en la presencia de una masa quística de tejido pulmonar afuncional que puede carecer de una obvia comunicación con el árbol traqueobronquial y recibe toda o la mayor parte de su irrigación sanguínea de vasos anómalos provenientes de la circulación sistémica. Teniendo en cuenta que la presentación de esta afección resulta rara comparada con otras afecciones pulmonares (entre 1 y 2 % de todas las resecciones pulmonares y que además lo más frecuente resulta su tratamiento definitivo antes de la edad adulta, se presenta el caso de un hombre de 44 años que acudió a consulta por presentar episodios frecuentes de neumonías desde hacía más de 10 años, que fueron diagnosticados como «bronquiectasias». Se discuten los hechos más significativos del origen embriológico de esta afección, características anatomopatológicas, clasificación, diagnóstico imaginológico, detalles del tratamiento quirúrgico y evolución posoperatoria.Pulmonary sequestration is a congenital affection consisting in the presence of a cystic mass of no-functional pulmonary tissue without an obvious communication with tracheobronchial tree and that receives all or most of its bloodstream of the anomalous vessels from systemic circulation. Taking into account that presentation of this affection is rare compared to other pulmonary affections (between the 1% and the 2% of all pulmonary resections and that also the more usual is its definitive treatment before adulthood. The case of man aged 44 is presented coming to consultation due to frequent episodes of pneumonias from more 10 years ago diagnosed as a bronchiectasis. The more significant facts of embryology origin of this affection including: anatomical and pathological features, imaging diagnosis, surgical treatment details, and postoperative course.

  11. [Pulmonary-renal syndrome].

    Science.gov (United States)

    Risso, Jorge A; Mazzocchi, Octavio; De All, Jorge; Gnocchi, César A

    2009-01-01

    The pulmonary-renal syndrome is defined as a combination of diffuse alveolar hemorrhage and glomerulonephritis. The coexistence of these two clinical conditions is due to diseases with different pathogenic mechanisms. Primary systemic vasculitis and Goodpasture syndrome are the most frequent etiologies. Systemic lupus erythematosus, connective tissue diseases, negative anti neutrophil cytoplasmic antibody vasculitis and those secondary to drugs are far less common causes. An early diagnosis based on clinical, radiologic, laboratory and histologic criteria enables early treatment, thus diminishing its high morbidity-mortality rate. Therapy is based on high doses of corticosteroids, immunosuppressants, tumor necrosis factor inhibitors and plasmapheresis.

  12. Fluoxetin-induced pulmonary granulomatosis.

    Science.gov (United States)

    de Kerviler, E; Trédaniel, J; Revlon, G; Groussard, O; Zalcman, G; Ortoli, J M; Espié, M; Hirsch, A; Frija, J

    1996-03-01

    A patient treated with fluoxetin for a manic depressive disorder developed pulmonary inflammatory nodules with noncaseating giant cell granulomas, interstitial pneumonia and non-necrotizing vasculitis, whilst remaining asymptomatic. A progressive resolution of pulmonary nodules occurred after withdrawal of the offending agent, and the chest radiograph returned to normal in 9 months. The diagnosis was assessed by an open lung biopsy.

  13. Thrombolytic therapy in pulmonary embolism.

    LENUS (Irish Health Repository)

    Nagi, D

    2010-01-01

    Massive pulmonary embolism carries a high mortality. Potential treatment includes anticoagulation, thrombolytic therapy and embolectomy. We report a case of deep vein thrombosis leading to progressive massive pulmonary embolism despite appropriate anticoagulation, where thrombolysis with IVC filter placement resulted in a successful outcome.

  14. THROMBOENDARTERECTOMY FOR CHRONIC PULMONARY THROMBOEMBOLISM

    Institute of Scientific and Technical Information of China (English)

    Hua Ren; Pi-xiong Su; Chao-ji Zhang; Song Gu; Heng Zhang; Chen Wang

    2005-01-01

    Objective To evaluate the improving reliability and safety of thromboendarterectomy and perioperative management for chronic pulmonary thromboembolism. Methods The clinical data of 12 cases with chronic pulmonary thromboembolism, who underwent thromboendarterec tomy assisted by low flow or circulation arrest with deep hypothermia, were reviewed retrospectively. Results Pulmonary artery pressure decreased 20 to 40 mmHg immediately after surgical procedures in 9 cases. The postoperative pulmonary edema at various degrees happened in 12 cases, among them, 1 died of severe lung infection and pulmonary re-embolism at 19 days postoperation. Computed tomography pulmonary angiography and angiography of 11 cases indicated that the original obstruction of pulmonary artery disappeared. During the follow-up period of 2 months to 5 years, the clinical symptoms and activity was improved. Conclusion Thromboendarterectomy is an effective treatment for chronic pulmonary thromboembolism. The outcome of the surgical procedure needs to be further investigated and followed up regularly according to an evaluative system, because it might be influenced by multiple factors.

  15. Pulmonary edema following lumbar puncture

    Directory of Open Access Journals (Sweden)

    Gupta D

    1977-01-01

    Full Text Available In a boy of 17 years with disseminated tuberculosis, sudden onset of pulmonary edema following lumbar puncture is described. Possible pat ho-mechanisms have been discussed. The link bet-ween the lumbar puncture and the development of pulmonary edema is not casual.

  16. SUPPORTED DENSE CERAMIC MEMBRANES FOR OXYGEN SEPARATION

    Energy Technology Data Exchange (ETDEWEB)

    Timothy L. Ward

    2002-07-01

    Mixed-conducting ceramics have the ability to conduct oxygen with perfect selectivity at elevated temperatures, making them extremely attractive as membrane materials for oxygen separation and membrane reactor applications. While the conductivity of these materials can be quite high at elevated temperatures (typically 800-1000 C), much higher oxygen fluxes, or, alternatively, equivalent fluxes at lower temperatures, could be provided by supported thin or thick film membrane layers. Based on that motivation, the objective of this project was to explore the use of ultrafine aerosol-derived powder of a mixed-conducting ceramic material for fabrication of supported thick-film dense membranes. The project focused on the mixed-conducting ceramic composition SrCo{sub 0.5}FeO{sub x} (SCFO) because of the desirable permeability and stability of that material, as reported in the literature. Appropriate conditions to produce the submicron SrCo{sub 0.5}FeO{sub x} powder using aerosol pyrolysis were determined. Porous supports of the same composition were produced by partial sintering of a commercially obtained powder that possessed significantly larger particle size than the aerosol-derived powder. The effects of sintering conditions (temperature, atmosphere) on the porosity and microstructure of the porous discs were studied, and a standard support fabrication procedure was adopted. Subsequently, a variety of paste and slurry formulations were explored utilizing the aerosol-derived SCFO powder. These formulations were applied to the porous SCFO support by a doctor blade or spin coating procedure. Sintering of the supported membrane layer was then conducted, and additional layers were deposited and sintered in some cases. The primary characterization methods were X-ray diffraction and scanning electron microscopy, and room-temperature nitrogen permeation was used to assess defect status of the membranes.We found that non-aqueous paste/slurry formulations incorporating

  17. Pulmonary complications in neurosurgical patients

    Directory of Open Access Journals (Sweden)

    Randeep Guleria

    2012-01-01

    Full Text Available Pulmonary complications are a major cause of morbidity and mortality in neurosurgical patients. The common pulmonary complications in neurosurgical patients include pneumonia, postoperative atelectasis, respiratory failure, pulmonary embolism, and neurogenic pulmonary edema. Postoperative lung expansion strategies have been shown to be useful in prevention of the postoperative complications in surgical patients. Low tidal volume ventilation should be used in patients who develop acute respiratory distress syndrome. An antibiotic use policy should be put in practice depending on the local patterns of antimicrobial resistance in the hospital. Thromboprophylactic strategies should be used in nonambulatory patients. Meticulous attention should be paid to infection control with a special emphasis on hand-washing practices. Prevention and timely management of these complications can help to decrease the morbidity and mortality associated with pulmonary complications.

  18. [Pulmonary manifestations in rheumatoid arthritis].

    Science.gov (United States)

    Morawska, Justyna; Domysławska, Izabela; Bagrowska, Magdalena; Sierakowski, Stanislaw

    2015-01-01

    Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by destructive cartilages, bones and other structures formed joints. RA belongs to connective tissue diseases represented by systemic nature, internal illness, extra-articular features and rapidly progress of atherosceirosis. The extra-articular complications cause the reduction of patient longevity. The frequency of symptoms in patient with RA and respiratory disorders occur in 10-20% of cases. Pulmonary complications are the second most common cause of premature of patient deaths. Respiratory disorders associated with RA are devided into 3 groups: infection, lung disease caused by drugs and pulmonary manifestation connected by RA. These last affect interstitial tissue, bronchioli, pulmonary vessels, pleura, also are presented by pulmonary rheumatoid nodules and pulmonary hypertension.

  19. Negative-Pressure Pulmonary Edema.

    Science.gov (United States)

    Bhattacharya, Mallar; Kallet, Richard H; Ware, Lorraine B; Matthay, Michael A

    2016-10-01

    Negative-pressure pulmonary edema (NPPE) or postobstructive pulmonary edema is a well-described cause of acute respiratory failure that occurs after intense inspiratory effort against an obstructed airway, usually from upper airway infection, tumor, or laryngospasm. Patients with NPPE generate very negative airway pressures, which augment transvascular fluid filtration and precipitate interstitial and alveolar edema. Pulmonary edema fluid collected from most patients with NPPE has a low protein concentration, suggesting hydrostatic forces as the primary mechanism for the pathogenesis of NPPE. Supportive care should be directed at relieving the upper airway obstruction by endotracheal intubation or cricothyroidotomy, institution of lung-protective positive-pressure ventilation, and diuresis unless the patient is in shock. Resolution of the pulmonary edema is usually rapid, in part because alveolar fluid clearance mechanisms are intact. In this review, we discuss the clinical presentation, pathophysiology, and management of negative-pressure or postobstructive pulmonary edema.

  20. Fermion mass and the pressure of dense matter

    CERN Document Server

    Fraga, Eduardo S; 10.1063/1.2714447

    2008-01-01

    We consider a simple toy model to study the effects of finite fermion masses on the pressure of cold and dense matter, with possible applications in the physics of condensates in the core of neutron stars and color superconductivity.

  1. Fabrication, Properties and Applications of Dense Hydroxyapatite: A Review

    Directory of Open Access Journals (Sweden)

    Mythili Prakasam

    2015-12-01

    Full Text Available In the last five decades, there have been vast advances in the field of biomaterials, including ceramics, glasses, glass-ceramics and metal alloys. Dense and porous ceramics have been widely used for various biomedical applications. Current applications of bioceramics include bone grafts, spinal fusion, bone repairs, bone fillers, maxillofacial reconstruction, etc. Amongst the various calcium phosphate compositions, hydroxyapatite, which has a composition similar to human bone, has attracted wide interest. Much emphasis is given to tissue engineering, both in porous and dense ceramic forms. The current review focusses on the various applications of dense hydroxyapatite and other dense biomaterials on the aspects of transparency and the mechanical and electrical behavior. Prospective future applications, established along the aforesaid applications of hydroxyapatite, appear to be promising regarding bone bonding, advanced medical treatment methods, improvement of the mechanical strength of artificial bone grafts and better in vitro/in vivo methodologies to afford more particular outcomes.

  2. Densely crosslinked polycarbosiloxanes .2. Thermal and mechanical properties

    NARCIS (Netherlands)

    Flipsen, T.A C; Derks, R.; van der Vegt, H.A.; Stenekes, R.; Pennings, A.J; Hadziioannou, G

    1997-01-01

    The thermal and mechanical properties of two densely crosslinked polycarbosiloxane systems were investigated in relation to the molecular structure. The networks were prepared from functional branched prepolymers and crosslinked via a hydrosilylation curing reaction. The prepolymers having only viny

  3. RESEARCH ON DENSITY STABILITY OF AIR DENSE MEDIUM FLUIDIZED BED

    Institute of Scientific and Technical Information of China (English)

    骆振福; 陈清如

    1994-01-01

    In this papcr on thc basis of studying the distribution of fine coal in the dense medium fluidized bed, the optimal size range of fine coal, which constitutes a fluidized bed together with the dense medium, has been found. In the separating process the fine coal will continuously accumulate in fluidized bed, thus inevitably reducing the density of the bed. In order to keep bed density stable, the authors adopted such measures as split-flow of used medium and complement of fresh dense medium. The experiment results in both lab and pilot systems of the air-dense medium fluidized bed show that these measures are effective and satisfactory. Then authors also have established some relative dynamic mathematical models for it.

  4. Automated Motion Estimation for 2D Cine DENSE MRI

    Science.gov (United States)

    Gilliam, Andrew D.; Epstein, Frederick H.

    2013-01-01

    Cine displacement encoding with stimulated echoes (DENSE) is a magnetic resonance (MR) method that directly encodes tissue displacement into MR phase images. This technique has successfully interrogated many forms of tissue motion, but is most commonly used to evaluate cardiac mechanics. Currently, motion analysis from cine DENSE images requires manually delineated anatomical structures. An automated analysis would improve measurement throughput, simplify data interpretation, and potentially access important physiological information during the MR exam. In this article, we present the first fully automated solution for the estimation of tissue motion and strain from 2D cine DENSE data. Results using both simulated and human cardiac cine DENSE data indicate good agreement between the automated algorithm and the standard semi-manual analysis method. PMID:22575669

  5. A Green Method for Processing Polymers using Dense Gas Technology

    Directory of Open Access Journals (Sweden)

    Roshan B. Yoganathan

    2010-05-01

    Full Text Available Dense CO2 can be used as an environmentally-benign polymer processing medium because of its liquid-like densities and gas-like mass transfer properties.In this work, polymer bio-blends of polycarbonate (PC, a biocompatible polymer, and polycaprolactone (PCL, a biodegradable polymer were prepared. Dense CO2 was used as a reaction medium for the melt-phase PC polymerization in the presence of dense CO2-swollen PCL particles and this method was used to prepare porous PC/PCL blends. To extend the applicability of dense CO2 to the biomedical industry and polymer blend processing, the impregnation of ibuprofen into the blend was conducted and subsequent dissolution characteristics were observed.

  6. Complete multiple round quantum dense coding with quantum logical network

    Institute of Scientific and Technical Information of China (English)

    LI ChunYan; LI XiHan; DENG FuGuo; ZHOU Ping; ZHOU HongYu

    2007-01-01

    We present a complete multiple round quantum dense coding scheme for improving the source capacity of that introduced recently by Zhang et al. The receiver resorts to two qubits for storing the four local unitary operations in each round.

  7. Neutrinos and Nucleosynthesis in Hot and Dense Matter

    Energy Technology Data Exchange (ETDEWEB)

    Fuller, George [Univ. of California, San Diego, CA (United States)

    2016-01-14

    The Topical Collaboration for Neutrinos and Nucleosynthesis in Hot and Dense matter brought together researchers from a variety of nuclear science specialties and a number of institutions to address nuclear physics and neutrino physics problems associated with dense matter and the origin of the elements. See attached final technical reports for (1) the UCSD award and (2) a copy of the report for the whole TC

  8. MICROSPRAY SIMULATION OF DENSE GAS DISPERSION IN COMPLEX TERRAIN

    OpenAIRE

    Anfossi, D.; Tinarelli, G.; S. Trini Castelli; Commanay, J.; Nibart, M

    2008-01-01

    Abstract: An extended validation of the new Lagrangian particle model MicroSpray version for dense gas simulation is proposed. MicroSpray simulates the dense gas dispersion in situations characterized by the presence of buildings, other obstacles, complex terrain, and possible occurrence of low wind speed conditions. Its performances are compared to a chlorine railway accident (Macdona), to a field experiment (Kit Fox) and to an atmospheric CFD model.

  9. Measurement of Electron-Ion Relaxation in Warm Dense Copper

    Science.gov (United States)

    Cho, B. I.; Ogitsu, T.; Engelhorn, K.; Correa, A. A.; Ping, Y.; Lee, J. W.; Bae, L. J.; Prendergast, D.; Falcone, R. W.; Heimann, P. A.

    2016-01-01

    Experimental investigation of electron-ion coupling and electron heat capacity of copper in warm and dense states are presented. From time-resolved x-ray absorption spectroscopy, the temporal evolution of electron temperature is obtained for non-equilibrium warm dense copper heated by an intense femtosecond laser pulse. Electron heat capacity and electron-ion coupling are inferred from the initial electron temperature and its decrease over 10 ps. Data are compared with various theoretical models.

  10. Relating quantum discord with the quantum dense coding capacity

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xin; Qiu, Liang, E-mail: lqiu@cumt.edu.cn; Li, Song; Zhang, Chi [China University of Mining and Technology, School of Sciences (China); Ye, Bin [China University of Mining and Technology, School of Information and Electrical Engineering (China)

    2015-01-15

    We establish the relations between quantum discord and the quantum dense coding capacity in (n + 1)-particle quantum states. A necessary condition for the vanishing discord monogamy score is given. We also find that the loss of quantum dense coding capacity due to decoherence is bounded below by the sum of quantum discord. When these results are restricted to three-particle quantum states, some complementarity relations are obtained.

  11. Pulmonary manifestation of leptospirosis

    Energy Technology Data Exchange (ETDEWEB)

    Im, Jung Gi; Yeon, Kyung Mo; Han, Man Chung; Kim, Chu Wan; Lee, Jung Sang; Kim, Suhng Gwon; Han, Yong Chol; Chang, Woo Hyun; Chi, Je Geun [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1986-02-15

    Authors analysed and present chest X-ray findings of serologically proven leptospirosis from Seoul National University Hospital, either admitted or referred for serological verification, during recent 2 years. Radiological findings were correlated with the lung specimen findings of experimentally induced leptospirosis in guinea pig. The results are as follows: 1. 24 cases (56%) showed positive X-ray findings. 2. Predominant radiological patterns of involved lung were tiny dot, small nodule, rosette density in 11 cases, massive confluent consolidation in 4 cases, and diffuse ill-defined velly increased density in 9 cases. 3. Distribution of pulmonary lesions were bilateral (100%), non-lobar, non-segmental (95%), and there were conspicuous tendency of peripheral lung predominance. 4. Extrapulmonary manifestation, such as pleural effusion or cardiomegaly was rate. 5. Pulmonary lesions resolved completely usually 5 to 10 days after their appearance. 6. From the gross and microscopic findings of serially sacrificed guinea pig's lung and a case of autopsy, authors concluded that fine dot-like density in chest X-ray was due to paleolithic hemorrhage in intraalveolar space at initial stage, growing up to ressette density or confluent consolidation as the pathetic extends to surrounding lung forming purpura and coalescent hemorrhage.

  12. Pulmonary alveolar proteinosis

    Directory of Open Access Journals (Sweden)

    B. Crestani

    2011-06-01

    Full Text Available Pulmonary alveolar proteinosis (PAP is a rare pulmonary disease characterised by alveolar accumulation of surfactant. It may result from mutations in surfactant proteins or granulocyte macrophage-colony stimulating factor (GM-CSF receptor genes, it may be secondary to toxic inhalation or haematological disorders, or it may be auto-immune, with anti-GM-CSF antibodies blocking activation of alveolar macrophages. Auto-immune alveolar proteinosis is the most frequent form of PAP, representing 90% of cases. Although not specific, high-resolution computed tomography shows a characteristic “crazy paving” pattern. In most cases, bronchoalveolar lavage findings establish the diagnosis. Whole lung lavage is the most effective therapy, especially for auto-immune disease. Novel therapies targeting alveolar macrophages (recombinant GM-CSF therapy or anti-GM-CSF antibodies (rituximab and plasmapheresis are being investigated. Our knowledge of the pathophysiology of PAP has improved in the past 20 yrs, but therapy for PAP still needs improvement.

  13. Proteomics in pulmonary medicine.

    Science.gov (United States)

    Bowler, Russell P; Ellison, Misoo C; Reisdorph, Nichole

    2006-08-01

    Proteomics is the study of the entire protein complement of the genome (the proteome) in a biological system. Proteomic studies require a multidisciplinary approach and have only been practical with the convergence of technical and methodologic improvements including the following: advances in mass spectrometry and genomic sequencing that now permit the identification and relative quantization of small amounts (femtomole) of nearly any single protein; new methods in gel electrophoresis that allow the detection of subtle changes in protein expression, including posttranslational modifications; automation and miniaturization that permit high-throughput analysis of clinical samples; and new bioinformatics and computational methods that facilitate analysis and interpretation of the abundant data that are generated by proteomics experiments. This convergence makes proteomics studies practical for pulmonary researchers using BAL fluid, lung tissue, blood, and exhaled breath condensates, and will facilitate the research of complex, multifactorial lung diseases such as acute lung injury and COPD. This review describes how proteomics experiments are conducted and interpreted, their limitations, and how proteomics has been used in clinical pulmonary medicine.

  14. Congenital pulmonary lymphangiectasia

    Directory of Open Access Journals (Sweden)

    Campisi Corradino

    2006-10-01

    Full Text Available Abstract Congenital pulmonary lymphangiectasia (PL is a rare developmental disorder involving the lung, and characterized by pulmonary subpleural, interlobar, perivascular and peribronchial lymphatic dilatation. The prevalence is unknown. PL presents at birth with severe respiratory distress, tachypnea and cyanosis, with a very high mortality rate at or within a few hours of birth. Most reported cases are sporadic and the etiology is not completely understood. It has been suggested that PL lymphatic channels of the fetal lung do not undergo the normal regression process at 20 weeks of gestation. Secondary PL may be caused by a cardiac lesion. The diagnostic approach includes complete family and obstetric history, conventional radiologic studies, ultrasound and magnetic resonance studies, lymphoscintigraphy, lung functionality tests, lung biopsy, bronchoscopy, and pleural effusion examination. During the prenatal period, all causes leading to hydrops fetalis should be considered in the diagnosis of PL. Fetal ultrasound evaluation plays a key role in the antenatal diagnosis of PL. At birth, mechanical ventilation and pleural drainage are nearly always necessary to obtain a favorable outcome of respiratory distress. Home supplemental oxygen therapy and symptomatic treatment of recurrent cough and wheeze are often necessary during childhood, sometimes associated with prolonged pleural drainage. Recent advances in intensive neonatal care have changed the previously nearly fatal outcome of PL at birth. Patients affected by PL who survive infancy, present medical problems which are characteristic of chronic lung disease.

  15. Primary pulmonary choriocarcinoma

    Science.gov (United States)

    Snoj, Ziga; Kocijancic, Igor

    2017-01-01

    Abstract Background The aim of the study was to establish whether there are different clinical entities of primary pulmonary choriocarcinoma (PPC) that deserve different diagnostic approach and the most optimal treatment. Patients and methods A systematic review with PubMed search was conducted to identify studies that reported cases of PPC. The eligibility criteria were histological diagnosis of pulmonary choriocarcinoma and thorough examination of the reproductive organs to exclude potential primary choriocarcinoma in the gonads. Furthermore, to illustrate the review we additionally present a patient referred at our institution. Results 55 cases (17 men) were included in the review with a median age of 34 years. Women with the history of gestational event showed better survival outcome than women without the history of gestational event. Patients treated with combined modality treatment (surgery and chemotherapy) survived longer than the patients without combined modality treatment. Furthermore, multivariate analysis of prognostic factors showed that the combined modality treatment had independent prognostic significance. Size of the tumour showed significant prognostic influence in univariate and multivariate analysis. Conclusions PPC is an extreme rarity with variable clinical characteristics and outcome. It is important to capture and treat patients in the early stages of the disease. Women with the history of gestational event may show better survival, therefore genetic examination could help us to predict patient’s prognosis. Surgery followed by adjuvant chemotherapy appears to represent the best treatment for PPC.

  16. October 2013 pulmonary journal club: pulmonary artery hypertension

    Directory of Open Access Journals (Sweden)

    Mathew M

    2013-10-01

    Full Text Available No abstract available. Article truncated at 150 words. Pulido T, Adzerikho I, Channick RN, Delcroix M, Galiè N, Ghofrani HA, Jansa P, Jing ZC, Le Brun FO, Mehta S, Mittelholzer CM, Perchenet L, Sastry BK, Sitbon O, Souza R, Torbicki A, Zeng X, Rubin LJ, Simonneau G; SERAPHIN Investigators. Macitentan and morbidity and mortality in pulmonary arterial hypertension. N Engl J Med. 2013;369(9:809-18. The October pulmonary journal club was focused on pulmonary hypertension. We reviewed a total of 5 articles on pulmonary hypertension. The 2 articles on riociguat that appeared in the New England Journal of Medicine have been reviewed and summarized in the September Pulmonary Journal Club (1-3. Current therapies in the treatment of pulmonary hypertension have been based on their efficacy in improving exercise tolerance and 6 minute walk time. Macitentan is a new endothelin receptor antagonist that has now been approved by the FDA for the treatment of Class I pulmonary hypertension. The trial was …

  17. Incidência de opacificação de cápsula posterior em pacientes submetidos à facoemulsificação e implante de lentes intra-oculares acrílicas hidrofílicas expansíveis Incidence of posterior capsule opacification in patients submitted to phacoemulsification and expandable acrylic intraocular lens implantation

    Directory of Open Access Journals (Sweden)

    Hilton Arcoverde Gonçalves de Medeiros

    2006-06-01

    Full Text Available OBJETIVO: Avaliar prospectivamente os resultados das lentes intra-oculares de polímeros expansíveis implantadas em pacientes submetidos à facoemulsificação, quanto à incidência de opacificação de cápsula posterior, levando em consideração a biocompatibilidade das lentes expansíveis. MÉTODOS: O grupo de estudo foi composto por 830 pacientes, 1.200 olhos, que foram submetidos a facoemulsificação, utilizando a mesma técnica, variando-se apenas o diâmetro da capsulorrexe, pelo mesmo cirurgião, no período de 1998 a 2002, com implante de lente intra-ocular hidrofílica expansível. O acompanhamento médio foi de 2,4 anos, variando de seis meses a quatro anos. RESULTADOS: O número total de opacificação de cápsula posterior foi de 54 casos. CONCLUSÃO: A incidência de opacificação de cápsula posterior encontrada no grupo foi de 4,6%.PURPOSE: To evaluate prospectively the results of expandable acrylic intraocular lenses in patients submitted to phacoemulsification as regard posterior capsule opacification. METHODS: The study group consisted of 830 patients, 1,200 eyes that underwent phacoemulsification from 1998 to 2002, by the same surgeon, using the same technique but with different diameters of capsulorrhexis, with expandable hydrophilic acrylic intraocular lens implantation. The mean follow-up was 2.4 years, ranging from 6 months to 4 years. RESULTS: The total number of posterior capsule opacification was 54 cases. CONCLUSIONS: The incidence of posterior capsule opacification was 4.6% in these patients.

  18. Persistent diffuse pulmonary interstitial emphysema mimicking pulmonary emphysema.

    Science.gov (United States)

    Demura, Y; Ishizaki, T; Nakanishi, M; Ameshima, S; Itoh, H

    2009-01-01

    A 69-year-old male non-smoker with a history of atopic asthma presented with symptoms suggestive of chronic obstructive pulmonary disease and this appeared to be corroborated by lung function testing and a chest radiograph. However, a chest CT showed no evidence of pulmonary emphysema and instead demonstrated free air along the bronchovascular sheaths indicative of pulmonary interstistial emphysema, possibly caused by repeated prior exacerbations of asthma. His lung function tests and symptoms improved within months of being treated for his airways disease but the CT findings were unchanged after 2 years.

  19. Meandering right pulmonary vein associated with severe and progressive "idiopathic-like" pulmonary hypertensive vascular disease.

    Science.gov (United States)

    Cuenca, Sofia; Bret, Montserrat; del Cerro, Maria Jesus

    2016-03-01

    Congenital anomalies of the pulmonary veins are rare. Meandering right pulmonary vein, considered a part of the Scimitar syndrome spectrum, is often an incidental finding during chest imaging. We present the case of a 4-year-old girl diagnosed with meandering pulmonary vein, who developed pulmonary hypertensive disease with an aggressive course, in spite of absence of hypoxia or elevated pulmonary wedge pressure.

  20. Pulmonary alveolar microlithiasis with calcified pleural plaques

    Directory of Open Access Journals (Sweden)

    Malhotra Balbir

    2010-01-01

    Full Text Available Pulmonary alveolar microlithiasis (PAM is a rare disease. Herein we report a case of pulmonary alveolar microlithiasis who was suspected to have the disease on chest X-ray and was confirmed on high resolution CT and transbronchial lung biopsy. These investigations showed characteristic features of pulmonary alveolar microlithiasis with diffuse interstitial pulmonary fibrosis.

  1. Anomalous pulmonary venous return: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Gyeong Min; Kang, MinJin; Lee, Han Bee; Bae, Kyung Eun; Lee, Jaehe; Kim, Jae Hyung; Jeong, Myeong Ja; Kang, Tae Kyung [Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of)

    2013-10-15

    Partial anomalous pulmonary venous return is a type of congenital pulmonary venous anomaly. We present a rare type of partial pulmonary venous return, subaortic vertical vein drains left lung to superior vena cava, accompanying hypoplasia of the ipsilateral lung and pulmonary artery. We also review the previous report and relationship of these structures.

  2. Pulmonary complications in renal transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jung Bin; Choi, Yo Won; Jeon, Seok Chol; Park, Choong Ki; Lee, Seung Rho; Hahm, Chang Kok; Joo, Kyung Bin [Hanyang University College of Medicine, Seoul (Korea, Republic of)

    2003-04-01

    To evaluate the radiographic and CT findings of pulmonary complications other than pulmonary edema arising from renal transplantation. Among 393 patients who had undergone renal transplantation at our hospital during a previous ten-year period, 23 with pulmonary complications other than pulmonary edema were included in this study. The complications involved were infection caused by CMV (n=6), bacteria (n=4), fungus (n=4), tuberculosis (n=2), varicella (n=1) or chlamydia (n=1), and malignancy involving lung cancer (n=4) or Kaposi's sarcoma (n=1). Two chest radiologists reviewed all images. The complications manifesting mainly as pulmonary nodules were lung cancer (4/4), tuberculosis (1/2), and Kaposi's sarcoma (1/1). Pulmonary consolidation was a main feature in bacterial infection (4/4), fungal infection (3/4), tuberculosis (1/2), chlamydial infection (1/1), and varicellar pneumonia (1/1). Ground-glass attenuation was a main CT feature in CMV pneumonia (4/6), and increased interstitial making was a predominant radiographic feature in CMV pneumonia (2/6). The main radiologic features described above can be helpful for differential diagnosis of the pulmonary complications of renal transplantation.

  3. Non-congenital heart disease associated pediatric pulmonary arterial hypertension

    OpenAIRE

    Ivy, D D; Feinstein, J. A.; Humpl, T; Rosenzweig, E. B.

    2009-01-01

    Recognition of causes of pulmonary hypertension other than congenital heart disease is increasing in children. Diagnosis and treatment of any underlying cause of pulmonary hypertension is crucial for optimal management of pulmonary hypertension. This article discusses the available knowledge regarding several disorders associated with pulmonary hypertension in children: idiopathic pulmonary arterial hypertension (IPAH), pulmonary capillary hemangiomatosis, pulmonary veno-occlusive disease, he...

  4. Pulmonary Edema: Classification, Mechanisms of Development, Diagnosis

    Directory of Open Access Journals (Sweden)

    V. V. Moroz

    2009-01-01

    Full Text Available Pulmonary edema remains a topical problem of modern reanimatology. In clinical practice, there is a need for continuous monitoring of the content of extravascular water in the lung and the pulmonary vascular permeability index for the timely detection and treatment of pulmonary edema. This literature review considers the minor mechanisms of pulmonary extravas-cular water exchange in health and in different types of pulmonary edema (acute lung injury, pneumonia, sepsis, postoperative period, burns, injuries etc., as well as the most accessible current (irradiation and dilution studies permitting an estimate of the level of pulmonary extravascular water and the pulmonary vascular permeability index in clinical practice. Key words: pulmonary edema, acute lung injury, pulmonary extravascular water, pulmonary vascular permeability index.

  5. Rescue surgical pulmonary embolectomy for acute massive pulmonary embolism

    Directory of Open Access Journals (Sweden)

    Ahmed Abdulrahman Elassal

    2016-08-01

    Conclusion: Surgical pulmonary embolectomy is a rescue operation in high-risk PE. It could save patients with preoperative cardiac arrest. Early diagnosis, interdisciplinary team action, appropriate and emergent treatment strategy are necessary for favorable outcome.

  6. Pulmonary alveolar microlithiasis

    Directory of Open Access Journals (Sweden)

    Surender Kashyap

    2013-01-01

    Full Text Available Pulmonary alveolar microlithiasis (PAM is a rare, chronic lung disease with bilateral intra-alveolar calcium and phosphate deposition throughout the lung parenchyma with predominance to lower and midzone. Although, etiology and pathogenesis of PAM is not fully understood, the mutation in SLC34A2 gene that encodes a sodium-phosphate co-transporter in alveolar type II cells resulting in the accumulation and forming of microliths rich in calcium phosphate (due to impaired clearance are considered to be the cause of the disease. Chest radiograph and high-resolution CT of thorax are nearly pathognomonic for diagnosing PAM. HRCT demonstrates diffuse micronodules showing slight perilobular predominance resulting in calcification of interlobular septa. Patients with PAM are asymptomatic till development of hypoxemia and cor-pulmonale. No therapy has been proven to be beneficial except lung transplantation.

  7. Acute pulmonary embolism.

    Science.gov (United States)

    Kuriakose, Jean; Patel, Smita

    2010-02-01

    CT pulmonary angiography has become a first-line imaging test for evaluation of PE because of its high accuracy, ease of use, and ready availability. PIOPED II supports the use of multidetector CT as a first-line test especially in outpatients. Technological advances continue to evolve, and with refinements in technology, we will continue to optimize imaging for PE detection. lonizing radiation remains a concern particularly in the young and in pregnant patients, and methods to decrease these are being advocated. SPECT V/Q may play a bigger role in PE diagnosis in the future and the role of MR is yet to be determined in the PIOPED ll study, with the potential of solving some of the issues regarding radiation in a select group of patients.

  8. Pulmonary Embolism in Children

    Directory of Open Access Journals (Sweden)

    Ahmar Urooj Zaidi

    2017-08-01

    Full Text Available Pulmonary embolism (PE in the pediatric population is relatively rare when compared to adults; however, the incidence is increasing and accurate and timely diagnosis is critical. A high clinical index of suspicion is warranted as PE often goes unrecognized among children leading to misdiagnosis and potentially increased morbidity and mortality. Evidence-based guidelines for the diagnosis, management, and follow-up of children with PE are lacking and current practices are extrapolated from adult data. Treatment options include thrombolysis and anticoagulation with heparins and oral vitamin K antagonists, with newer direct oral anticoagulants currently in clinical trials. Long-term sequelae of PE, although studied in adults, are vastly unknown among children and adolescents. Additional research is needed in order to provide pediatric focused care for patients with acute PE.

  9. Pulmonary Hypertension in Pregnancy: Critical Care Management

    OpenAIRE

    Bassily-Marcus, Adel M.; Carol Yuan; John Oropello; Anthony Manasia; Roopa Kohli-Seth; Ernest Benjamin

    2012-01-01

    Pulmonary hypertension is common in critical care settings and in presence of right ventricular failure is challenging to manage. Pulmonary hypertension in pregnant patients carries a high mortality rates between 30–56%. In the past decade, new treatments for pulmonary hypertension have emerged. Their application in pregnant women with pulmonary hypertension may hold promise in reducing morbidity and mortality. Signs and symptoms of pulmonary hypertension are nonspecific in pregnant women. Im...

  10. Pulmonary mucormycosis mimicking as pulmonary tuberculosis : A case report

    Directory of Open Access Journals (Sweden)

    Garg Rajiv

    2008-01-01

    Full Text Available Pulmonary Mucormycosis is an uncommon disease caused by fungi of class Zygomycetes. It occurs predminantly in an immunodeficient host most common risk factor being diabetes mellitus. The lesions are localized in the lungs or the mediastinum. We are reporting a case of 70 years old male, having cough, haemoptysis, fever and chest pain. He was on antituberculosis treatment (RHEZ for last 10 days and was later found to have Pulmonary Mucormycosis on further evaluation.

  11. Pulmonary mucormycosis mimicking as pulmonary tuberculosis: a case report.

    Science.gov (United States)

    Garg, Rajiv; Marak, Rungmei Sk; Verma, Sanjay Kumar; Singh, Jagdeep; Sanjay; Prasad, Rajendra

    2008-07-01

    Pulmonary Mucormycosis is an uncommon disease caused by fungi of class Zygomycetes. It occurs predminantly in an immunodeficient host most common risk factor being diabetes mellitus. The lesions are localized in the lungs or the mediastinum. We are reporting a case of 70 years old male, having cough, haemoptysis, fever and chest pain. He was on antituberculosis treatment (RHEZ) for last 10 days and was later found to have Pulmonary Mucormycosis on further evaluation.

  12. Pulmonary endarterectomy in the management of chronic thromboembolic pulmonary hypertension

    Directory of Open Access Journals (Sweden)

    David Jenkins

    2017-03-01

    Full Text Available Chronic thromboembolic pulmonary hypertension (CTEPH is a type of pulmonary hypertension, resulting from fibrotic transformation of pulmonary artery clots causing chronic obstruction in macroscopic pulmonary arteries and associated vascular remodelling in the microvasculature. Pulmonary endarterectomy (PEA offers the best chance of symptomatic and prognostic improvement in eligible patients; in expert centres, it has excellent results. Current in-hospital mortality rates are 90% at 1 year and >70% at 10 years. However, PEA, is a complex procedure and relies on a multidisciplinary CTEPH team led by an experienced surgeon to decide on an individual's operability, which is determined primarily by lesion location and the haemodynamic parameters. Therefore, treatment of patients with CTEPH depends largely on subjective judgements of eligibility for surgery by the CTEPH team. Other controversies discussed in this article include eligibility for PEA versus balloon pulmonary angioplasty, the new treatment algorithm in the European Society of Cardiology/European Respiratory Society guidelines and the definition of an “expert centre” for the management of this condition.

  13. Anatomic distribution of embolus at CT pulmonary angiography in patients suspected acute pulmonary embolism

    Institute of Scientific and Technical Information of China (English)

    朱力

    2013-01-01

    Objective To summarize and analyze the morphology and distribution of embolus in patients suspected acute pulmonary embolism. Methods The CT pulmonary angiography(CTPA) imagings of 279 patients suspected acute pulmonary embolism were analyzed retrospectively in

  14. Análise da camada de fibras nervosas pelo GDx em pacientes pseudofácicos com opacidades da cápsula posterior Analysis of the nerve fiber layer using GDx in pseudophakic patients with posterior capsular opacification

    Directory of Open Access Journals (Sweden)

    Tatiana Azevedo Arraes

    2008-02-01

    Full Text Available OBJETIVO: Avaliar se a opacificação de cápsula posterior (OCP influenciaria na análise da camada de fibras nervosas pela polarimetria "scanning laser" (GDx. MÉTODOS: Trinta e sete pacientes pseudofácicos não glaucomatosos foram submetidos a análise da camada de fibras nervosas pelo GDx antes e após a realização de capsulotomia com Nd:YAG laser. RESULTADOS: Em cinco olhos, o GDx não conseguiu imagens aceitáveis pelos parâmetros de aquisição do aparelho. Em todos os outros, não foi observada diferença significante entre os valores médios das variáveis antes e após a realização da capsulotomia posterior. CONCLUSÃO: A presença de OCP em graus moderados e/ou quando há imagens aceitáveis em pacientes pseudofácicos não influencia o resultado da análise das imagens das fibras do nervo óptico pelo GDx. Apenas intensos graus de OCP que impeçam a obtenção de imagem analisável pelo aparelho inviabilizam o exame.PURPOSE: To evaluate if posterior capsule opacification (PCO would alter the analysis of nerve fiber layer using the scanning laser polarimetry (GDx. METHODS: Pseudophakic non-glaucomatosous eyes (37 patients underwent nerve fiber layer analysis using GDx before and after posterior capsulotomy with Nd:YAG Laser. RESULTS: In five eyes, GDx did not obtain acceptable images using the device's parameters of acquisition. In the others, mean variable values did not reach significant difference before and after posterior capsulotomy. CONCLUSION: Moderate degrees of PCO and/or acceptable images in pseudophakic patients do not alter the analysis of nerve fiber layer by GDx. Only intense degrees of PCO that hinder analyzable images make the examination impracticable.

  15. 不同类型和部位后发性白内障对视功能的影响%The effect of location and type of posterior capsule opacification on visual function

    Institute of Scientific and Technical Information of China (English)

    姜良柱; 吴明星; 苏明山; 闫莹

    2009-01-01

    目的 应用计算机图像分析软件评价后发性白内障(posterior capsule opacification,PCO)的形态,以探讨不同类型、部位PCO对最佳矫正视力(best corrected visual acuity,BCVA)、对比敏感度(contrast sensitivity,CS)和眩光敏感度glare sensitivity,GS)的影响.方法 收集拟行激光后囊切开术的PCO患者61例(67眼),充分散瞳,行详细眼科检查后,应用裂隙灯照相获取PCO后照法照片,使用PCO计算机分析软件(FOCOman软件)对其进行形态学分析.同时分别测量所有患者激光后囊切开术术前及术后1周BCVA、CS、GS.分析不同类型、不同部位PCO对BCVA、CS、GS的影响.结果 珍珠型PCO的BCVA、各频段CS和CS均低于纤维型PCO,且两者之间的差异有统计学意义(P<0.05).其中,4.0 mm珍珠型PCO在低、中频段CS和中频段GS均低于中央2.0 mm珍珠型PCO,差异有统计学意义(P<0.05);中央2.0 mm纤维型PCO在中、高频段CS和低、中频段GS均低于中央4.0 mm纤维型PCO,差异有统计学意义(P<0.05).中央2.0 mm珍珠型PCO时BCVA的影响最为显著:中央4.0 mm珍珠型PC0对CS和GS的影响最为显著.结论 珍珠型PCO对BCVA、各频段CS和GS的彩响大于纤维型PCO.珍珠型PCO在中央4.0 mm区对视功能的影响大于中央2.0 mm区:纤维型PCO在中央2.0 mm区对视功能的影响大于中央4.0 mm区.

  16. 信封式后囊剪除术治疗纤维性后发障32例的疗效观察%Evelope posterior capsulectomy in the treatment of 32 patients with posterior capsule opacification

    Institute of Scientific and Technical Information of China (English)

    韦乐强

    2013-01-01

    目的:探讨信封式后囊膜剪除术治疗纤维性后发障的方法、疗效及并发症。方法选择该院32例明确诊断为纤维性后发障患者行信封式后囊膜剪除术治疗,记录手术前后视力、眼压变化以及术后并发症的发生情况。结果所有患者均成功剪除瞳孔区的后发障组织,恢复透明,视力提高,从术前平均视力0.15恢复到术后第1天平均视力0.3,术后1周平均视力0.6,无一例发生人工晶体移位、视网膜脱离、黄斑水肿等并发症。结论信封式后囊膜剪除术是治疗纤维性后发障的一种行之有效的方法,但因该术式对手术医师技术要求高,建议应严格把握手术适应证。%Objective To explore the efficacy and complications of envelope posterior capsulectomy in the treatment of fibrous posterior capsule opacification ( PCO) .Methods A retrospective analysis was performed of com-plete follow-up data of 32 patients fibrous PCO undergoing the evelope posterior capsulectomy including visual acuity , intraocular pressure ,and postoperative complications before and after surgery .Results All patients were successfully cut off the PCO tissue in the pupil area , the transparency recovered ,visual acuity improved from preoperative average 0.15 to 0.3 at fist postoperative day and reached 0.6 at 1 week after operation .No cases of lens displacement , reti-nal detachment , macular edema and other complication were found.Co nclusion Envelope posterior capsulectomy in the treatment of fibrous PCO is an effective method , but the surgeon should have skilled technology and strictly grasp the indications for surgery .

  17. The JCMT dense gas survey in dense molecular clouds: an HCO+/HCN comparison

    Science.gov (United States)

    Walker-Smith, Samantha; Richer, John; Buckle, Jane; Salji, Carl; Hatchell, Jennifer; Drabek, Emily

    2013-07-01

    We present the results of a large-scale survey of the very dense molecular gas in Perseus, Orion A and B, Serpens and Ophiuchus using HCO+ and HCN (J = 4 - 3) transitions. We have used this emission to trace the structure and kinematics of gas at the extremely high densities found in pre- and protostellar cores; as well as tracing outflows powered by these early star-forming cores. We present a comparison of the HCO+/HCN data, highlighting regions where there is a marked discrepancy in the spectra of the two emission lines. This is particularly noticeable in some of the more powerful outflows driven by Class 0 sources, where the HCN is greatly enhanced in the linewings in comparison with HCO+. We also use the HCO+ to positively identify protostellar outflows and their driving sources. We present a statistical analysis of the outflow properties that we derive from this tracer. We show that our results are comparable to those obtained from similar outflow analyses using 12CO.

  18. Experimental Studies of the Transport Parameters of Warm Dense Matter

    Energy Technology Data Exchange (ETDEWEB)

    Chouffani, Khalid [Idaho State Univ., Pocatello, ID (United States)

    2014-12-01

    There is a need to establish fundamental properties of matter and energy under extreme physical conditions. Although high energy density physics (HEDP) research spans a wide range of plasma conditions, there is one unifying regime that is of particular importance and complexity: that of warm dense matter, the transitional state between solid state condensed matter and energetic plasmas. Most laboratory experimental conditions, including inertial confinement implosion, fall into this regime. Because all aspects of laboratory-created high-energy-density plasmas transition through the warm dense matter regime, understanding the fundamental properties to determine how matter and energy interact in this regime is an important aspect of major research efforts in HEDP. Improved understanding of warm dense matter would have significant and wide-ranging impact on HEDP science, from helping to explain wire initiation studies on the Sandia Z machine to increasing the predictive power of inertial confinement fusion modeling. The central goal or objective of our proposed research is to experimentally determine the electrical resistivity, temperature, density, and average ionization state of a variety of materials in the warm dense matter regime, without the use of theoretical calculations. Since the lack of an accurate energy of state (EOS) model is primarily due to the lack of experimental data, we propose an experimental study of the transport coefficients of warm dense matter.

  19. Dense Molecular Gas: A Sensitive Probe of Stellar Feedback Models

    CERN Document Server

    Hopkins, Philip F; Murray, Norman; Quataert, Eliot

    2012-01-01

    We show that the mass fraction of GMC gas (n>100 cm^-3) in dense (n>>10^4 cm^-3) star-forming clumps, observable in dense molecular tracers (L_HCN/L_CO(1-0)), is a sensitive probe of the strength and mechanism(s) of stellar feedback. Using high-resolution galaxy-scale simulations with pc-scale resolution and explicit models for feedback from radiation pressure, photoionization heating, stellar winds, and supernovae (SNe), we make predictions for the dense molecular gas tracers as a function of GMC and galaxy properties and the efficiency of stellar feedback. In models with weak/no feedback, much of the mass in GMCs collapses into dense sub-units, predicting L_HCN/L_CO(1-0) ratios order-of-magnitude larger than observed. By contrast, models with feedback properties taken directly from stellar evolution calculations predict dense gas tracers in good agreement with observations. Changing the strength or timing of SNe tends to move systems along, rather than off, the L_HCN-L_CO relation (because SNe heat lower-de...

  20. Current status of pulmonary metastasectomy

    DEFF Research Database (Denmark)

    Hornbech, Kåre; Ravn, Jesper; Steinbrüchel, Daniel Andreas

    2011-01-01

    for unresected patients. In this article, we discuss the current status on pulmonary metastasectomy. Preoperative assessment and selection of surgical candidates is covered. The different surgical strategies including surgical approach, unilateral versus bilateral exploration, lymph node dissection, and repeat...

  1. Cytologic features of pulmonary blastoma

    Directory of Open Access Journals (Sweden)

    Sai Shalini C

    2009-01-01

    Full Text Available Pulmonary blastomas are rare lung neoplasms constituting 0.5% of all lung tumors. This tumor has an aggressive course and needs to be recognized on cytology. A preoperative diagnosis of pulmonary blastoma is difficult to obtain by cytopathologic methods. A diagnosis of biphasic pulmonary blastoma should be considered when there is a dimorphic population of cells on cytology. A 30-year-old male presented with gradually progressing breathlessness and left-sided chest pain for the past one month. Chest radiograph and computed tomography of thorax revealed an anterior mediastinal mass that was subjected to ultrasound-guided fine-needle aspiration cytology. Aspiration cytology showed a highly cellular lesion with a dimorphic population of tumor cells in a necrotic background. The possibility of a non-small cell carcinoma was suggested. Subsequent histopathology revealed the tumor to be a pulmonary blastoma. The importance of recognizing the dimorphic population of cells in cytology is discussed.

  2. Pulmonary fibrosis associated with nabumetone.

    OpenAIRE

    Morice, A.; Atherton, A.; GLEESON, F; Stewart, S.

    1991-01-01

    A patient is described who developed a rapid onset of pulmonary fibrosis following treatment with a new non-steroidal anti-inflammatory drug, nabumetone. Resolution of symptoms, physical signs and radiographic changes followed drug withdrawal and steroid therapy.

  3. Pulmonary ventilation/perfusion scan

    Science.gov (United States)

    V/Q scan; Ventilation/perfusion scan; Lung ventilation/perfusion scan ... A pulmonary ventilation/perfusion scan is actually two tests. They may be done separately or together. During the perfusion scan, a health care provider injects ...

  4. Heart Failure and Pulmonary Hypertension

    OpenAIRE

    Shin, Jordan T.; Semigran, Marc J.

    2010-01-01

    When PH and RV dysfunction accompany HF, the impact on functional capacity and prognosis are ominous. Newer clinical strategies to preferentially lower pulmonary pressures and pulmonary vascular tone improve functional performance and symptoms of heart failure by targeting the NO signal transduction pathways as with PDE5 inhibition. Additional studies are needed to delineate if these therapies will impact long-term patient outcomes and to elucidate the specific mechanisms whereby these treatm...

  5. Treatment of Hantavirus Pulmonary Syndrome

    Science.gov (United States)

    2007-10-14

    Clinical syndrome Hantaviruses cause a spectrum of vascular-leak syndromes n humans ranging from proteinuria to pulmonary edema and rank hemorrhage...of fatal illness. The illness is haracterized by fever and vascular leakage resulting in noncar- iogenic pulmonary edema followed in severe cases by...cardiopulmonary syndrome (HCPS) o emphasize the important role of cardiogenic shock; among ospitalized patients, death almost invariably results from

  6. Pulmonary metastasectomy in pediatric patients

    OpenAIRE

    Erginel, Basak; Gun Soysal, Feryal; Keskin, Erbug; Kebudi, Rejin; Celik, Alaaddin; SALMAN, Tansu

    2016-01-01

    Background This study aims to evaluate the outcomes of pulmonary metastasectomy resections in pediatric patients. Methods We retrospectively reviewed the medical records of 43 children who were operated on in the Pediatric Surgery Clinic between January 1988 and 2014. Forty-three children (26 boys; 17 girls; mean age 10???4.24?years, range 6?months?18?years) who underwent pulmonary metastasectomy resection were included in the study. The patients were evaluated based on age, gender, history o...

  7. Occupational chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Omland, Oyvind; Würtz, Else Toft; Aasen, Tor Børvig

    2014-01-01

    Occupational-attributable chronic obstructive pulmonary disease (COPD) presents a substantial health challenge. Focusing on spirometric criteria for airflow obstruction, this review of occupational COPD includes both population-wide and industry-specific exposures.......Occupational-attributable chronic obstructive pulmonary disease (COPD) presents a substantial health challenge. Focusing on spirometric criteria for airflow obstruction, this review of occupational COPD includes both population-wide and industry-specific exposures....

  8. Pulmonary mechanics during mechanical ventilation.

    Science.gov (United States)

    Henderson, William R; Sheel, A William

    2012-03-15

    The use of mechanical ventilation has become widespread in the management of hypoxic respiratory failure. Investigations of pulmonary mechanics in this clinical scenario have demonstrated that there are significant differences in compliance, resistance and gas flow when compared with normal subjects. This paper will review the mechanisms by which pulmonary mechanics are assessed in mechanically ventilated patients and will review how the data can be used for investigative research purposes as well as to inform rational ventilator management.

  9. Treatment of pediatric pulmonary hypertension

    Directory of Open Access Journals (Sweden)

    Amy Hawkins

    2009-06-01

    Full Text Available Amy Hawkins, Robert TullohDepartment of Congenital Heart Disease, Bristol Royal Hospital for Children, Bristol UKAbstract: Pulmonary hypertension was once thought to be a rare condition and only managed in specialized centers. Now however, with the advent of echocardiography, it is found in many clinical scenarios, in the neonate with chronic lung disease, in the acute setting in the intensive care unit, in connective tissue disease and in cardiology pre- and postoperatively. We have a better understanding of the pathological process and have a range of medication which is starting to be able to palliate this previously fatal condition. This review describes the areas that are known in this condition and those that are less familiar. The basic physiology behind pulmonary hypertension and pulmonary vascular disease is explained. The histopathologic process and the various diagnostic tools are described and are followed by the current and future therapy at our disposal.Keywords: pulmonary hypertension, congenital heart disease, pulmonary vascular resistance, pulmonary vasodilators

  10. Pulmonary agenesis: two cases reported

    Directory of Open Access Journals (Sweden)

    Denis Yaraví Solano-Vázquez

    2014-11-01

    Full Text Available Background: Pulmonary agenesis is a rare anomaly (1 in 15 000 live births which consists in a total absence or severe hypoplasia of one or both lungs. The clinical spectrum of the unilateral agenesis could vary from early and severe respiratory distress, recurrent pneumonia to being an incidental finding. The prognosis is based on the presence of associated congenital abnormalities. Material and methods: We present two cases of unilateral pulmonary agenesis in patients at Tlaxcala’s Children Hospital during 2012. Results: Report details the case of a one-month old boy with left pulmonary agenesis and interatrial communication and mild pulmonary arterial hypertension. He had two resolved pneumonia incidents. The other case was a one-month old girl with right pulmonary agenesis, associated to multiple heart malformations who evolved to respiratory failure, heart failure and death.Conclusions: Pulmonary agenesis is a rare anomaly. Its outcome and prognosis varies with the hemodynamics related to its location and associated malformations.

  11. Pulmonary hypertension in dialysis patients.

    Science.gov (United States)

    Kosmadakis, George; Aguilera, Didier; Carceles, Odette; Da Costa Correia, Enrique; Boletis, Ioannis

    2013-01-01

    Pulmonary hypertension in end-stage renal disease patients is associated with significantly increased morbidity and mortality. The prevalence of pulmonary hypertension in dialysis patients is relatively high and varies in different studies from 17% to 49.53% depending on the mode of dialysis and other selection factors, such as the presence of other cardiovascular comorbidities. The etiopathogenic mechanisms that have been studied in relatively small studies mainly include arteriovenous fistula-induced increased cardiac output, which cannot be accomodated by, the spacious under normal conditions pulmonary circulation. Additionally, pulmonary vessels show signs of endothelial dysfunction, dysregulation of vascular tone due to an imbalance in vasoactive substances, and local as well as systemic inflammation. It is also believed that microbubbles escaping from the dialysis circuit can trigger vasoconstriction and vascular sclerosis. The non-specific therapeutic options that proved to be beneficial in pulmonary artery pressure reduction are endothelin inhibitors, phosphodiesterase inhibitor sildenafil, and vasodilatory prostaglandins in various forms. The specific modes of treatment are renal transplantation, size reduction or closure of high-flow arteriovenous fistulas, and transfer from hemodialysis to peritoneal dialysis-a modality that is associated with a lesser prevalence of pulmonary hypertension.

  12. Pulmonary veno-occlusive disease.

    Science.gov (United States)

    Montani, David; Lau, Edmund M; Dorfmüller, Peter; Girerd, Barbara; Jaïs, Xavier; Savale, Laurent; Perros, Frederic; Nossent, Esther; Garcia, Gilles; Parent, Florence; Fadel, Elie; Soubrier, Florent; Sitbon, Olivier; Simonneau, Gérald; Humbert, Marc

    2016-05-01

    Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension (PH) characterised by preferential remodelling of the pulmonary venules. In the current PH classification, PVOD and pulmonary capillary haemangiomatosis (PCH) are considered to be a common entity and represent varied expressions of the same disease. The recent discovery of biallelic mutations in the EIF2AK4 gene as the cause of heritable PVOD/PCH represents a major milestone in our understanding of the molecular pathogenesis of PVOD. Although PVOD and pulmonary arterial hypertension (PAH) share a similar clinical presentation, with features of severe precapillary PH, it is important to differentiate these two conditions as PVOD carries a worse prognosis and life-threatening pulmonary oedema may occur following the initiation of PAH therapy. An accurate diagnosis of PVOD based on noninvasive investigations is possible utilising oxygen parameters, low diffusing capacity for carbon monoxide and characteristic signs on high-resolution computed tomography of the chest. No evidence-based medical therapy exists for PVOD at present and lung transplantation remains the preferred definitive therapy for eligible patients.

  13. Balloon pulmonary angioplasty: a treatment option for inoperable patients with chronic thromboembolic pulmonary hypertension

    Directory of Open Access Journals (Sweden)

    Aiko eOgawa

    2015-02-01

    Full Text Available In chronic thromboembolic pulmonary hypertension, stenoses or obstructions of the pulmonary arteries due to organized thrombi can cause an elevation in pulmonary artery resistance, which in turn can result in pulmonary hypertension. Chronic thromboembolic pulmonary hypertension can be cured surgically by pulmonary endarterectomy; however, patients deemed unsuitable for pulmonary endarterectomy due to lesion, advanced age, or comorbidities have a poor prognosis and limited treatment options. Recently, advances have been made in balloon pulmonary angioplasty for these patients, and this review highlights this recent progress.

  14. CT pulmonary angiography of adult pulmonary vascular diseases: Technical considerations and interpretive pitfalls.

    Science.gov (United States)

    Taslakian, Bedros; Latson, Larry A; Truong, Mylene T; Aaltonen, Eric; Shiau, Maria C; Girvin, Francis; Alpert, Jeffrey B; Wickstrom, Maj; Ko, Jane P

    2016-11-01

    Computed tomography pulmonary angiography (CTPA) has become the primary imaging modality for evaluating the pulmonary arteries. Although pulmonary embolism is the primary indication for CTPA, various pulmonary vascular abnormalities can be detected in adults. Knowledge of these disease entities and understanding technical pitfalls that can occur when performing CTPA are essential to enable accurate diagnosis and allow timely management. This review will cover a spectrum of acquired abnormalities including pulmonary embolism due to thrombus and foreign bodies, primary and metastatic tumor involving the pulmonary arteries, pulmonary hypertension, as well as pulmonary artery aneurysms and stenoses. Additionally, methods to overcome technical pitfalls and interventional treatment options will be addressed.

  15. Local Crystalline Structure in an Amorphous Protein Dense Phase.

    Science.gov (United States)

    Greene, Daniel G; Modla, Shannon; Wagner, Norman J; Sandler, Stanley I; Lenhoff, Abraham M

    2015-10-20

    Proteins exhibit a variety of dense phases ranging from gels, aggregates, and precipitates to crystalline phases and dense liquids. Although the structure of the crystalline phase is known in atomistic detail, little attention has been paid to noncrystalline protein dense phases, and in many cases the structures of these phases are assumed to be fully amorphous. In this work, we used small-angle neutron scattering, electron microscopy, and electron tomography to measure the structure of ovalbumin precipitate particles salted out with ammonium sulfate. We found that the ovalbumin phase-separates into core-shell particles with a core radius of ∼2 μm and shell thickness of ∼0.5 μm. Within this shell region, nanostructures comprised of crystallites of ovalbumin self-assemble into a well-defined bicontinuous network with branches ∼12 nm thick. These results demonstrate that the protein gel is comprised in part of nanocrystalline protein.

  16. Infrared Opacities in Dense Atmospheres of Cool White Dwarf Stars

    CERN Document Server

    Kowalski, Piotr M; Dufour, Patrick

    2016-01-01

    Dense, He-rich atmospheres of cool white dwarfs represent a challenge to the modeling. This is because these atmospheres are constituted of a dense fluid in which strong multi-atomic interactions determine their physics and chemistry. Therefore, the ideal-gas-based description of absorption is no longer adequate, which makes the opacities of these atmospheres difficult to model. This is illustrated with severe problems in fitting the spectra of cool, He-rich stars. Good description of the infrared (IR) opacity is essential for proper assignment of the atmospheric parameters of these stars. Using methods of computational quantum chemistry we simulate the IR absorption of dense He/H media. We found a significant IR absorption from He atoms (He-He-He CIA opacity) and a strong pressure distortion of the H$_2$-He collision-induced absorption (CIA). We discuss the implication of these results for interpretation of the spectra of cool stars.

  17. Infrared Opacities in Dense Atmospheres of Cool White Dwarf Stars

    Science.gov (United States)

    Kowalski, P. M.; Blouin, S.; Dufour, P.

    2017-03-01

    Dense, He-rich atmospheres of cool white dwarfs represent a challenge to the modeling. This is because these atmospheres are constituted of a dense fluid in which strong multi-atomic interactions determine their physics and chemistry. Therefore, the ideal-gas-based description of absorption is no longer adequate, which makes the opacities of these atmospheres difficult to model. This is illustrated with severe problems in fitting the spectra of cool, He-rich stars. Good description of the infrared (IR) opacity is essential for proper assignment of the atmospheric parameters of these stars. Using methods of computational quantum chemistry we simulate the IR absorption of dense He/H media. We found a significant IR absorption from He atoms (He-He-He CIA opacity) and a strong pressure distortion of the H2-He collision-induced absorption (CIA). We discuss the implication of these results for the interpretation of the spectra of cool stars.

  18. Laboratory measurements of the resistivity of warm dense plasmas

    Science.gov (United States)

    Booth, Nicola; Robinson, Alex; Hakel, Peter; Gregori, Ginaluca; Rajeev, Pattathil; Woolsey, Nigel

    2015-11-01

    In this talk we will present a method for studying material resistivity in warm dense plasmas in the laboratory in which we interrogate the microphysics of the low energy electron distributions associated with an anisotropic return current. Through experimental measurements of the polarization of the Ly- α doublet emission (2s1 / 2-2p1 / 2,3/2 transitions) of sulphur, we determine the resistivity of a sulphur-doped plastic target heated to warm dense conditions by an ultra-intense laser at relativistic intensities, I ~ 5 ×1020 Wcm-2. We describe a method of exploiting classical x-ray scattering to separately measure both the π- and σ- polarizations of Ly-α1 spectral emission in a single shot. These measurements make it possible to explore fundamental material properties such as resistivity in warm and hot dense plasmas through matching plasma physics modelling to atomic physics calculations of the experimentally measured large, positive, polarisation.

  19. Probing warm dense lithium by inelastic X-ray scattering

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Saiz, E.; Riley, D. [School of Mathematics and Physics, Queen' s University of Belfast, Belfast (United Kingdom); Gregori, G. [Clarendon Laboratory, University of Oxford, Parks Road, Oxford (United Kingdom); Gregori, G.; Clarke, R.J.; Neely, D.; Notley, M.M.; Spindloe, C. [Central Laser Facility, Rutherford Appleton Laboratory, Chilton, Didcot, OX (United Kingdom); Gericke, D.O.; Vorberger, J.; Wunsch, K. [Centre for Fusion, Space and Astrophysics, Department of Physics, University of Warwick, Coventry (United Kingdom); Barbrel, B.; Koenig, M. [Laboratoire pour l' Utilisation des Laser Intenses, Ecole Polytechnique - Universite Paris-6, 91 - Palaiseau (France); Freeman, R.R.; Weber, R.L.; Van Woerkom, L. [Department of Physics, The Ohio State University, Columbus, Ohio (United States); Glenzer, S.H.; Landen, O.L.; Neumayer, P.; Price, D. [Lawrence Livermore National Laboratory, Livermore, California (United States); Khattak, F.Y. [Department of Physics, Kohat University of Science and Technology, Kohat-26000, NWFP (Pakistan); Pelka, A.; Roth, M.; Schollmeier, M. [Institut fur Kernphysik, Technische Universitat Darmstadt (Germany)

    2008-10-15

    One of the grand challenges of contemporary physics is understanding strongly interacting quantum systems comprising such diverse examples as ultracold atoms in traps, electrons in high-temperature superconductors and nuclear matter. Warm dense matter, defined by temperatures of a few electron volts and densities comparable with solids, is a complex state of such interacting matter. Moreover, the study of warm dense matter states has practical applications for controlled thermonuclear fusion, where it is encountered during the implosion phase, and it also represents laboratory analogues of astrophysical environments found in the core of planets and the crusts of old stars. Here we demonstrate how warm dense matter states can be diagnosed and structural properties can be obtained by inelastic X-ray scattering measurements on a compressed lithium sample. Combining experiments and ab initio simulations enables us to determine its microscopic state and to evaluate more approximate theoretical models for the ionic structure. (authors)

  20. On the Evolution of the Dense Core Mass Function

    CERN Document Server

    Williams, Jonathan J Swift Jonathan P

    2008-01-01

    The mass distributions of dense cores in star-forming regions are measured to have a shape similar to the initial mass function of stars. This has been generally interpreted to mean that the constituent cores will form individual stars or stellar systems at a nearly constant star formation efficiency. This article presents a series of numerical experiments evolving distributions of dense cores into stars to quantify the effects of stellar multiplicity, global core fragmentation, and a varying star formation efficiency. We find that the different evolutionary schemes have an overall small effect on the shape of the resultant distribution of stars. Our results imply that at the current level of observational accuracy the comparison between the mass functions of dense cores and stars alone is insufficient to discern between different evolutionary models. Observations over a wide range of mass scales including the high or low-mass tails of these distributions have the largest potential for discerning between diff...

  1. DENSE: Displacement Encoding with Stimulated Echoes in Cardiac Functional MRI

    Science.gov (United States)

    Aletras, Anthony H.; Ding, Shujun; Balaban, Robert S.; Wen, Han

    1999-03-01

    Displacement encoding with stimulated echoes (DENSE) was developed for high-resolution myocardial displacement mapping. Pixel phase is modulated by myocardial displacement and data spatial resolution is limited only by pixel size. 2D displacement vector maps were generated for the systolic action in canines with 0.94 × 1.9 mm nominal in-plane resolution and 2.3 mm/π displacement encoding. A radial strain of 0.208 was measured across the free left ventricular wall over 105 ms during systole. DENSE displacement maps require small first-order gradient moments for encoding. DENSE magnitude images exhibit black-blood contrast which allows for better myocardial definition and reduced motion-related artifacts.

  2. Spatial and temporal segmented dense trajectories for gesture recognition

    Science.gov (United States)

    Yamada, Kaho; Yoshida, Takeshi; Sumi, Kazuhiko; Habe, Hitoshi; Mitsugami, Ikuhisa

    2017-03-01

    Recently, dense trajectories [1] have been shown to be a successful video representation for action recognition, and have demonstrated state-of-the-art results with a variety of datasets. However, if we apply these trajectories to gesture recognition, recognizing similar and fine-grained motions is problematic. In this paper, we propose a new method in which dense trajectories are calculated in segmented regions around detected human body parts. Spatial segmentation is achieved by body part detection [2]. Temporal segmentation is performed for a fixed number of video frames. The proposed method removes background video noise and can recognize similar and fine-grained motions. Only a few video datasets are available for gesture classification; therefore, we have constructed a new gesture dataset and evaluated the proposed method using this dataset. The experimental results show that the proposed method outperforms the original dense trajectories.

  3. Distributed quantum dense coding with two receivers in noisy environments

    Science.gov (United States)

    Das, Tamoghna; Prabhu, R.; SenDe, Aditi; Sen, Ujjwal

    2015-11-01

    We investigate the effect of noisy channels in a classical information transfer through a multipartite state which acts as a substrate for the distributed quantum dense coding protocol between several senders and two receivers. The situation is qualitatively different from the case with one or more senders and a single receiver. We obtain an upper bound on the multipartite capacity which is tightened in the case of the covariant noisy channel. We also establish a relation between the genuine multipartite entanglement of the shared state and the capacity of distributed dense coding using that state, both in the noiseless and the noisy scenarios. Specifically, we find that, in the case of multiple senders and two receivers, the corresponding generalized Greenberger-Horne-Zeilinger states possess higher dense coding capacities as compared to a significant fraction of pure states having the same multipartite entanglement.

  4. Warm dense matter and Thomson scattering at FLASH

    Energy Technology Data Exchange (ETDEWEB)

    Faeustlin, Roland Rainer

    2010-05-15

    X-ray free electron lasers are powerful tools to investigate moderately to strongly correlated solid density low temperature plasmas, named warm dense matter. These plasmas are of most interest for astrophysics and laser plasma interaction, particularly inertial confinement fusion. This work utilizes the ultrashort soft x-ray pulse duration and high brilliance of the free electron laser in Hamburg, FLASH, to generate warm dense matter and to study its ultrafast processes. The techniques applied are absorption measurement, emission spectroscopy and Thomson scattering. Radiative hydrodynamics and Thomson scattering simulations are used to investigate the impact of temperature and density gradients in the sample and to fit the experimental data. The measurements result in a comprehensive picture of soft x-ray matter interaction related to warm dense matter and yield insight into ultrafast equilibration and relaxation mechanisms, in particular impact ionization and radiative recombination. (orig.)

  5. Collaborative Research: Neutrinos & Nucleosynthesis in Hot Dense Matter

    Energy Technology Data Exchange (ETDEWEB)

    Reddy, Sanjay

    2013-09-06

    It is now firmly established that neutrinos, which are copiously produced in the hot and dense core of the supernova, play a role in the supernova explosion mechanism and in the synthesis of heavy elements through a phenomena known as r-process nucleosynthesis. They are also detectable in terrestrial neutrino experiments, and serve as a probe of the extreme environment and complex dynamics encountered in the supernova. The major goal of the UW research activity relevant to this project was to calculate the neutrino interaction rates in hot and dense matter of relevance to core collapse supernova. These serve as key input physics in large scale computer simulations of the supernova dynamics and nucleosynthesis being pursued at national laboratories here in the United States and by other groups in Europe and Japan. Our calculations show that neutrino production and scattering rate are altered by the nuclear interactions and that these modifications have important implications for nucleosynthesis and terrestrial neutrino detection. The calculation of neutrino rates in dense matter are difficult because nucleons in the dense matter are strongly coupled. A neutrino interacts with several nucleons and the quantum interference between scattering off different nucleons depends on the nature of correlations between them in dense matter. To describe these correlations we used analytic methods based on mean field theory and hydrodynamics, and computational methods such as Quantum Monte Carlo. We found that due to nuclear effects neutrino production rates at relevant temperatures are enhanced, and that electron neutrinos are more easily absorbed than anti-electron neutrinos in dense matter. The latter, was shown to favor synthesis of heavy neutron-rich elements in the supernova.

  6. Cloud photogrammetry with dense stereo for fisheye cameras

    Science.gov (United States)

    Beekmans, Christoph; Schneider, Johannes; Läbe, Thomas; Lennefer, Martin; Stachniss, Cyrill; Simmer, Clemens

    2016-11-01

    We present a novel approach for dense 3-D cloud reconstruction above an area of 10 × 10 km2 using two hemispheric sky imagers with fisheye lenses in a stereo setup. We examine an epipolar rectification model designed for fisheye cameras, which allows the use of efficient out-of-the-box dense matching algorithms designed for classical pinhole-type cameras to search for correspondence information at every pixel. The resulting dense point cloud allows to recover a detailed and more complete cloud morphology compared to previous approaches that employed sparse feature-based stereo or assumed geometric constraints on the cloud field. Our approach is very efficient and can be fully automated. From the obtained 3-D shapes, cloud dynamics, size, motion, type and spacing can be derived, and used for radiation closure under cloudy conditions, for example. Fisheye lenses follow a different projection function than classical pinhole-type cameras and provide a large field of view with a single image. However, the computation of dense 3-D information is more complicated and standard implementations for dense 3-D stereo reconstruction cannot be easily applied. Together with an appropriate camera calibration, which includes internal camera geometry, global position and orientation of the stereo camera pair, we use the correspondence information from the stereo matching for dense 3-D stereo reconstruction of clouds located around the cameras. We implement and evaluate the proposed approach using real world data and present two case studies. In the first case, we validate the quality and accuracy of the method by comparing the stereo reconstruction of a stratocumulus layer with reflectivity observations measured by a cloud radar and the cloud-base height estimated from a Lidar-ceilometer. The second case analyzes a rapid cumulus evolution in the presence of strong wind shear.

  7. Quantum Dense Coding in Multiparticle Entangled States via Local Measurements

    Institute of Scientific and Technical Information of China (English)

    陈建兰; 匡乐满

    2004-01-01

    We study quantum dense coding between two arbitrarily fixed particles in a (N + 2)-particle maximally-entangled states through introducing an auxiliary qubit and carrying out local measurements. It is shown that the transmitted classical information amount through such an entangled quantum channel is usually less than two classical bits. However, the information amount may reach two classical bits of information, and the classical information capacity is independent of the number of the entangled particles under certain conditions. The results offer deeper insight into quantum dense coding via quantum channels of multi-particle entangled states.

  8. Time-dependent models of dense PDRs with complex molecules

    OpenAIRE

    Morata, O.; Herbst, E.

    2008-01-01

    We present a study of the chemistry of a dense photon-dominated region (PDR) using a time-dependent chemical model. Our major interest is to study the spatial distribution of complex molecules such as hydrocarbons and cyanopolyynes in the cool dense material bordering regions where star formation has taken place. Our standard model uses a homogeneous cloud of density 2x10e4 cm-3 and temperature T=40 K, which is irradiated by a far-ultraviolet radiation field of intermediate intensity, given b...

  9. Dense Subsemigroups of Matrix Semigroups and Semigroups of Linear Transformations

    Institute of Scientific and Technical Information of China (English)

    Yupaporn Kemprasit

    2002-01-01

    Let V be a vector space over a field F = (F, +, .), F* = F\\{0}, LF(V)the semigroup of all linear transformations of V into itself under composition, and Mn(F) the multiplicative full n × n matrix semigroup over F. In this paper, it is proved that the semigroup Mn(F) has a proper dense subsemigroup if and only if(F*, .) has an element of infinite order. Also, the semigroup LF(V) has a proper dense subsemigroup if and only if dimF V = ∞ or (F*, .) has an element of infinite order.

  10. In-plant evaluation of dense medium process performances

    Energy Technology Data Exchange (ETDEWEB)

    R.Q. Honaker; A. Patwardhan [University of Kentucky, Lexington, KY (United States). Department of Mining Engineering

    2006-07-15

    The separation density and process efficiency values achieved by dense medium processes are a function of the particle size fractions being treated, hydrodynamics of the separator, and medium rheology. An in-plant evaluation of the dense medium processes being used in an operating preparation plant was conducted in an effort to develop relationships between the actual separation density and the medium density and to quantify the separation efficiency values. The results were found to correlate well with current fundamental and operating principles governing the processes, which are reviewed and discussed.

  11. Solving Dense Generalized Eigenproblems on Multi-threaded Architectures

    CERN Document Server

    Aliaga, José I; Davidović, Davor; Di Napoli, Edoardo; Igual, Francisco D; Quintana-Ortí, Enrique S

    2011-01-01

    We compare two approaches to compute a portion of the spectrum of dense symmetric definite generalized eigenproblems: one is based on the reduction to tridiagonal form, and the other on the Krylov-subspace iteration. Two large-scale applications, arising in molecular dynamics and material science, are employed to investigate the contributions of the application, architecture, and parallelism of the method to the performance of the solvers. The experimental results on a state-of-the-art 8-core platform, equipped with a graphics processing unit (GPU), reveal that in real applications, iterative Krylov-subspace methods can be a competitive approach also for the solution of dense problems.

  12. Monte Carlo simulation of electrons in dense gases

    Science.gov (United States)

    Tattersall, Wade; Boyle, Greg; Cocks, Daniel; Buckman, Stephen; White, Ron

    2014-10-01

    We implement a Monte-Carlo simulation modelling the transport of electrons and positrons in dense gases and liquids, by using a dynamic structure factor that allows us to construct structure-modified effective cross sections. These account for the coherent effects caused by interactions with the relatively dense medium. The dynamic structure factor also allows us to model thermal gases in the same manner, without needing to directly sample the velocities of the neutral particles. We present the results of a series of Monte Carlo simulations that verify and apply this new technique, and make comparisons with macroscopic predictions and Boltzmann equation solutions. Financial support of the Australian Research Council.

  13. Pulmonary oligemia maneuver can alleviate pulmonary artery injury during pulmonary thromboendarterectomy procedure

    Institute of Scientific and Technical Information of China (English)

    GAN Hui-li; ZHANG Jian-qun; LU Jia-kai; DONG Xiu-hua; HOU Xiao-tong; GAO Yuan-ming; ZHU Guang-fa

    2013-01-01

    Background Pulmonary thromboendarterectomy (PTE) has evolved as a treatment of choice for chronic thromboembolic pulmonary hypertension (CTEPH).This study aimed to characterize if pulmonary oligemia maneuver (POM) can alleviate pulmonary artery injury during PTE procedure.Methods A total of 112 cases of CTEPH admitted to Beijing Anzhen Hospital from March 2002 to August 2011 received PTE procedure.They were retrospectively classified as non-POM group (group A,n=55) or POM group (group B,n=57).Members from group B received POM during rewarming period,whereas members from group A did not.Results There were three (5.45%) early deaths in group A,no death in group B (0) (Fisher's exact test,P=-0.118).Six patients in group A needed extracorporeal membrane oxygenation (ECMO) as life support after the PTE procedure,no patients in group B needed ECMO (Fisher's exact test,P=0.013).The patients in group B had a shorter intubation and ICU stay,lower mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR),higher partial pressure of oxygen in artery (PaO2) and arterial oxygen saturation (SaO2) and less medical expenditure than patients in group A.With a mean follow-up time of (58.3 ± 30.6) months,two patients in group A and one patient in group B died.The difference of the actuarial survival after the procedure between the two groups did not reach statistical significance.Three months post the PTE procedure,the difference of residual occluded pulmonary segment between the two groups did not reach statistical significance (P=-0.393).Conclusion POM can alleviate pulmonary artery injury,shorten ICU stay and intubation time,and lower down the rate of ECMO after PTE procedure.

  14. [Pathophysiology and classification of pulmonary hypertension].

    Science.gov (United States)

    Sládková, H; Jansa, P; Susa, Z; Aschermann, M

    2004-09-01

    Pulmonary hypertension is present when the mean pulmonary pressure is increased above 25 mm Hg in a rest or above 30 mm Hg during exercise. It is possible to divide it from different point of view. Well known is pathophysiologic classification and Venice classification suggested by WHO symposium 2003. The rise of arterial pulmonary pressure is caused by three essential abnormalities, these are elevated pulmonary vascular resistance, blood flow and pulmonary artery wedge pressure. Vasoconstriction, remodeling of vessels and in situ trombosis are pathogenetic mechanism which contribute to rise of pulmonary hypertension.

  15. Inflammation and pulmonary hypertension.

    Science.gov (United States)

    Mathew, Rajamma

    2010-01-01

    Pulmonary hypertension (PH) is a serious disorder with high morbidity and mortality rate. Evidence is accumulating to suggest that inflammation plays a significant role in the pathogenesis of PH. Endothelial cells play an important role in inflammation and immune reactions, and inflammatory cytokines cause endothelial dysfunction. Endothelial dysfunction is a hallmark of PH, consisting of reduced availability of vasodilators and antiproliferative factors and increased production of vasoconstrictors and vascular proliferative factors. Up-regulation of inflammatory cytokines and perivascular inflammatory cell infiltration have been detected in the lungs of patients with idiopathic PH. Prevalence of PH in patients with systemic inflammatory diseases is well documented. Interestingly, a significant loss of endothelial caveolin-1, a potent immunomodulator and an inhibitor of cell proliferation, has been reported in human and experimental forms of PH. Reduction in the expression of caveolin-1 is known to result in the removal of antiproliferative activities, thus, leading to deregulated vascular cell proliferation. This article summarizes the roles of inflammation and endothelial caveolin-1 and their possible interrelationship in PH.

  16. PULMONARY CYSTIC ECHINOCOCCOSIS

    Science.gov (United States)

    Santivanez, Saul; Garcia, Hector H.

    2012-01-01

    Pulmonary cystic echinococosis, a zoonosis caused by the larvae of the dog tapeworm Echinococcus granulosus, is considered as a major public health problem in those countries where dogs are used to care for large herds because of the incapacitating effects produced in affected population. The ratio lung:liver involvement is higher in children than in adults. A higher proportion of lung cases are discovered incidentally on a routine x-ray evaluation; the majority of infected people remain asymptomatic until the cyst enlarges sufficiently to cause symptoms. The majority of symptoms are caused by mass effect from the cyst volume; the presence of complications caused by cysts broke changes the clinical presentation; the principal complication is cyst rupture, producing cough, chest pain, hemoptysis, or vomica. Diagnosis is obtained by imaging evaluation (Chest X-ray or CT scan), supported by serology in the majority of cases. Surgery is the main therapeutic approach, having as principal objective, the removal of the parasite, preventing intraoperative dissemination; the use of pre surgical chemotherapy reduces the chances of seeding and recurrence; treatment using benzimidazoles is the preferred treatment when surgery is not available, or complete removal is not feasible PMID:20216420

  17. CT Pulmonary Angiography and Suspected Acute Pulmonary Embolism

    Energy Technology Data Exchange (ETDEWEB)

    Enden, T.; Kloew, N.E. [Ullevaal Univ. Hospital, Oslo (Norway). Dept. of Cardiovascular Radiology

    2003-05-01

    Purpose: To evaluate the use and quality of CT pulmonary angiography in our department, and to relate the findings to clinical parameters and diagnoses. Material and Methods: A retrospective study of 324 consecutive patients referred to CT pulmonary angiography with clinically suspected pulmonary embolism (PE). From the medical records we registered clinical parameters, blood gases, D-dimer, risk factors and the results of other relevant imaging studies. Results: 55 patients (17%) had PE detected on CT. 39 had bilateral PE, and 8 patients had isolated peripheral PE. 87% of the examinations showing PE had satisfactory filling of contrast material including the segmental pulmonary arteries, and 60% of the subsegmental arteries. D-dimer test was performed in 209 patients, 85% were positive. A negative D-dimer ruled out PE detected at CT. Dyspnea and concurrent symptoms or detection of deep vein thrombosis (DVT), contraceptive pills and former venous thromboembolism (VTE) were associated with PE. The presence of only one clinical parameter indicated a negative PE diagnosis (p < 0.017), whereas two or more suggested a positive PE diagnosis (p < 0.002). CT also detected various ancillary findings such as consolidation, pleural effusion, nodule or tumor in nearly half of the patients; however, there was no association with the PE diagnosis. Conclusion: The quality of CT pulmonary angiography was satisfactory as a first-line imaging of PE. CT also showed additional pathology of importance in the chest. Our study confirmed that a negative D-dimer ruled out clinically suspected VTE.

  18. [Pulmonary scintigraphy in the diagnosis of pulmonary embolism].

    Science.gov (United States)

    Favretto, Giuseppe

    2002-01-01

    Pulmonary scintigraphy constitutes an important step in the non invasive diagnosis of pulmonary embolism (PE). This technique may be employed for the evaluation of the pulmonary perfusion alone, as in Italy and in the PISA-PED study, or else even for the evaluation of the pulmonary ventilation (as in Anglo-Saxon countries and in the PIOPED study). In the present study, the reasons which have prompted the ANMCO-SIC Commission for the Guidelines for The Prophylaxis, Diagnosis and Therapy of Pulmonary Thromboembolism to propose, for the diagnostic work-up of the patient with clinically suspected PE, the use of perfusion scintigraphy alone and of the classification criteria employed in the PISA-PED study instead of the more commonly utilized ventilatory-perfusion scintigraphy and of the criteria included in the PIOPED article, are discussed. Besides, the Commission's decision to consider PE as being present in case of agreement between the scintigraphic and clinical pictures, and to exclude this condition when the scintigraphic outcome is normal/almost normal regardless of the clinical probabilities, is also motivated.

  19. 超声乳化术后联合及不联合人工晶状体植入术建立后囊膜混浊兔眼模型的比较%Comparison of posterior capsular opacification models by phacoemulsification with or without intraocular lens implantation in rabbit

    Institute of Scientific and Technical Information of China (English)

    曹倩; 李兰; 李云川; 张远平; 查旭; 戴红梅; 梁毓琳; 杨文艳; 李静华

    2012-01-01

    背景 后发性白内障(PCO)的防治是目前研究的热点问题之一.建立PCO动物模型常用的方法为超声乳化术后植入或不植入人工晶状体(IOL),但二者造模的效果评价尚不一致. 目的 比较兔眼PCO模型建立过程中植入与不植入IOL对PCO的影响. 方法 选择新西兰白兔20只,用随机数字表法将实验动物分为超声乳化联合IOL植入组和超声乳化不植入IOL组,每组10只兔,两组兔右眼超声乳化手术过程一致,术后共随访3个月,裂隙灯下观察2个组术后晶状体的反应及PCO情况,按Odrich PCO分级系统对术眼PCO情况进行分级.结果 术后1~3d,超声乳化联合IOL植入组术眼结膜充血、角膜水肿和房水混浊的严重程度均明显比超声乳化不植入IOL组严重,而术后2周至3个月2个组兔眼的炎性反应均消失;术后ld至3个月,2个组兔术眼的瞳孔直径变化及PCO分级一致.术后2个月,超声乳化不植入IOL组及超声乳化联合IOL植入组兔眼1~3级PCO者分别为8只眼和9只眼,0级PCO者分别为2只眼和1只眼,组间差异无统计学意义(P=0.39).裂隙灯下检查发现2个组实验眼均于术后1个月开始出现PCO,术后2个月PCO的范围扩大并快速发展,术后3个月形成致密纤维化层.结论 采用超声乳化联合IOL植入术建立PCO模型的效果与不植入IOL者相同,但后者术后早期的前房炎性反应较轻,可作为研究PCO的理想动物模型.%Background Prevention and treatment of posterior capsular opacification (PCO) is a hot issue.To establish a PCO animal model is the basis of relevant studies.The most common methods of creating a PCO model are phacoemulsification surgery with or without intraocular lens (IOL) implantation.But the suitability of different methods is unclear.Objective This experiment was to compare the outcome between the two methods of establishing a PCO model in rabbit eyes.Methods Twenty New Zealand white rabbits were collected and

  20. Interaction of ultrarelativistic electron and proton bunches with dense plasmas

    CERN Document Server

    Rukhadze, A A

    2012-01-01

    Here we discuss the possibility of employment of ultrarelativistic electron and proton bunches for generation of high plasma wakefields in dense plasmas due to the Cherenkov resonance plasma-bunch interaction. We estimate the maximum amplitude of such a wake and minimum system length at which the maximum amplitude can be generated at the given bunch parameters.

  1. Dense Matter and Neutron Stars in Parity Doublet Models

    CERN Document Server

    Schramm, S; Negreiros, R; Steinheimer, J

    2011-01-01

    We investigate the properties of dense matter and neutron stars. In particular we discuss model calculations based on the parity doublet picture of hadronic chiral symmetry. In this ansatz the onset of chiral symmetry restoration is reflected by the degeneracy of baryons and their parity partners. In this approach we also incorporate quarks as degrees of freedom to be able to study hybrid stars.

  2. Length scales and selforganization in dense suspension flows

    NARCIS (Netherlands)

    Düring, G.; Lerner, E.; Wyart, M.

    2014-01-01

    Dense non-Brownian suspension flows of hard particles display mystifying properties: As the jamming threshold is approached, the viscosity diverges, as well as a length scale that can be identified from velocity correlations. To unravel the microscopic mechanism governing dissipation and its

  3. Antiproton beam polarizer using a dense polarized target

    Energy Technology Data Exchange (ETDEWEB)

    Wojtsekhowski, Bogdan

    2011-05-01

    We describe considerations regarding the spin filtering method for the antiproton beam. The proposed investigation of the double polarization cross section for antiproton to nucleon interaction is outlined. It will use a single path of the antiproton beam through a dense polarized target, e.g. 3He or CH2, followed by a polarimeter.

  4. Comprehensive Studies of Ultrafast Laser Excited Warm Dense Gold

    Science.gov (United States)

    Chen, Zhijiang; Mo, Mianzhen; Russell, Brandon; Tsui, Ying; Wang, Xijie; Ng, Andrew; Glenzer, Siegfried

    2016-10-01

    Isochoric excitation of solids by ultrafast laser pulses is an important approach to generate warm dense matter in laboratory. Electrical conductivity, structural dynamics and lattice stabilities are the most important properties in ultrafast laser excited warm dense matter. To investigate these properties, we have developed multiple advanced capabilities at SLAC recently, including the measurement of semi-DC electrical conductivity with ultrafast THz radiation, the study of solid and liquid structural dynamics by ultrafast electron diffraction (UED), and the investigation of lattice stability using frequency domain interferometry (FDI) on both front and rear surfaces. Due to the non-reversible nature in exciting solid to warm dense matter, all these diagnostics are implemented with single-shot approaches, reducing the uncertainties due to shot-to-shot fluctuations. In this talk, we will introduce these novel capabilities and present some highlighted studies in warm dense gold, which was uniformly excited by ultrafast laser pulses at 400nm. We appreciate the supports from DOE FES under FWP #100182.

  5. Rapid haplotype reconstruction in predigrees with dense marker maps

    NARCIS (Netherlands)

    Windig, J.J.; Meuwissen, T.H.E.

    2004-01-01

    Reconstruction of marker phases is not straightforward when parents are untyped. In these cases information from other relatives has to be used. In dense marker maps, however, the space of possible haplotype configurations tends to be too large for procedures such as Monte Carlo Markov chains (MCMC)

  6. Mechanics of dense suspensions in turbulent channel flows

    NARCIS (Netherlands)

    Picano, F.; Costa, P.; Breugem, W.P.; Brandt, L.

    2015-01-01

    Dense suspensions are usually investigated in the laminar limit where inertial effects are insignificant. When the flow rate is high enough, i.e. at high Reynolds number, the flow may become turbulent and the interaction between solid and liquid phases modifies the turbulence we know in single-phase

  7. On discrete Zariski-dense subgroups of algebraic groups

    CERN Document Server

    Winkelmann, J

    1993-01-01

    We investigate for which linear-algebraic groups (over the complex numbers or any local field) there exists subgroups which are dense in the Zariski topology, but discrete in the Hausdorff topology. For instance, such subgroups exist for every non-solvable complex group.

  8. Tableaux for Logics of Subinterval Structures over Dense Orderings

    DEFF Research Database (Denmark)

    Bresolin, Davide; Goranko, Valentin; Montanari, Angelo;

    2010-01-01

    In this article, we develop tableau-based decision procedures for the logics of subinterval structures over dense linear orderings. In particular, we consider the two difficult cases: the relation of strict subintervals (with both endpoints strictly inside the current interval) and the relation o...

  9. Gas-particle interactions in dense gas-fluidised beds

    NARCIS (Netherlands)

    Li, J.; Kuipers, J.A.M.

    2003-01-01

    The occurrence of heterogeneous flow structures in gas-particle flows seriously affects gas¿solid contacting and transport processes in dense gas-fluidized beds. A computational study, using a discrete particle method based on Molecular Dynamics techniques, has been carried out to explore the

  10. Dense Focal Plane Arrays for Pushbroom Satellite Radiometers

    DEFF Research Database (Denmark)

    Iupikov, O. A.; Ivashina, M. V.; Pontoppidan, K.

    2014-01-01

    Performance of a dense focal plane array feeding an offset toroidal reflector antenna system is studied and discussed in the context of a potential application in multi-beam radiometers for ocean surveillance. We present a preliminary design of the array feed for the 5-m diameter antenna at X...

  11. Manifestation of chiral symmetry restoration in a dense medium

    CERN Document Server

    Ericson, M; Delorme, J

    1999-01-01

    We generalize the concept of correlator mixing to the case of a dense baryonic medium. We study the subsequent modifications of the axial nucleonic coupling constant and the pion decay one. They arise from a two pion exchange current of a new type. We discuss the link to the condensate evolution.

  12. Numerical simulation of the fast dense gas Ludwieg tube experiment

    NARCIS (Netherlands)

    Zamfirescu, C.; Guerdone, A.; Collona, P.

    2006-01-01

    The preliminary design of a Ludwieg tube experiment for the verification of the existence of nonclassical rarefaction shock waves in dense vapors is here critically analyzed by means of real gas numerical simulations of the experimental setup. The Flexible Asymmetric Shock Tube (FAST) setup is a den

  13. Dense Descriptors for Optical Flow Estimation: A Comparative Study

    Directory of Open Access Journals (Sweden)

    Ahmadreza Baghaie

    2017-02-01

    Full Text Available Estimating the displacements of intensity patterns between sequential frames is a very well-studied problem, which is usually referred to as optical flow estimation. The first assumption among many of the methods in the field is the brightness constancy during movements of pixels between frames. This assumption is proven to be not true in general, and therefore, the use of photometric invariant constraints has been studied in the past. One other solution can be sought by use of structural descriptors rather than pixels for estimating the optical flow. Unlike sparse feature detection/description techniques and since the problem of optical flow estimation tries to find a dense flow field, a dense structural representation of individual pixels and their neighbors is computed and then used for matching and optical flow estimation. Here, a comparative study is carried out by extending the framework of SIFT-flow to include more dense descriptors, and comprehensive comparisons are given. Overall, the work can be considered as a baseline for stimulating more interest in the use of dense descriptors for optical flow estimation.

  14. Easy Fabrication of Dense Ceramic Membrane for Oxygen Separation

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A combined EDTA-citrate complexing method was developed for the easy preparation of mixed oxygen-ionic and electronic conducting dense ceramic membrane for oxygen separation.The new method takes the advantage of lower calcination temperature for phase formation, lower membrane sintering temperature and higher relative density over the standard ceramic method.

  15. Dry processing versus dense medium processing for preparing thermal coal

    CSIR Research Space (South Africa)

    De Korte, GJ

    2013-10-01

    Full Text Available in the region. In addition to not requiring water, the technique is less expensive than dense medium processing - both in terms of capital cost and operating cost. An added benefit when preparing coal for use in power stations is the lower moisture content...

  16. A comparative study of fast dense stereo vision algorithms

    NARCIS (Netherlands)

    Sunyoto, H.; Mark, W. van der; Gavrila, D.M.

    2004-01-01

    With recent hardware advances, real-time dense stereo vision becomes increasingly feasible for general-purpose processors. This has important benefits for the intelligent vehicles domain, alleviating object segmentation problems when sensing complex, cluttered traffic scenes. In this paper, we prese

  17. Multi-channel Support for Dense Wireless Sensor Networking

    NARCIS (Netherlands)

    Durmaz, O.; Dulman, S.O.; Jansen, P.G.; Havinga, Paul J.M.; Havinga, P.J.M.; Lijding, M.E.M.; Meratnia, N.; Meratnia, Nirvana; Wegdam, M.

    2006-01-01

    Currently, most wireless sensor network applications assume the presence of single-channel Medium Access Control (MAC) protocols. When sensor nodes are densely deployed, single-channel MAC protocols may be inadequate due to the higher demand for the limited bandwidth. To overcome this drawback, we

  18. A new mechanism for dendritic pattern formation in dense systems

    Science.gov (United States)

    Oikawa, Noriko; Kurita, Rei

    2016-06-01

    Patterns are often formed when particles cluster: Since patterns reflect the connectivity of different types of material, the emergence of patterns affects the physical and chemical properties of systems and shares a close relationship to their macroscopic functions. A radial dendritic pattern (RDP) is observed in many systems such as snow crystals, polymer crystals and biological systems. Although most of these systems are considered as dense particle suspensions, the mechanism of RDP formation in dense particle systems is not yet understood. It should be noted that the diffusion limited aggregation model is not applicable to RDP formation in dense systems, but in dilute particle systems. Here, we propose a simple model that exhibits RDP formation in a dense particle system. The model potential for the inter-particle interaction is composed of two parts, a repulsive and an attractive force. The repulsive force is applied to all the particles all the time and the attractive force is exerted only among particles inside a circular domain, which expands at a certain speed as a wave front propagating from a preselected centre. It is found that an RDP is formed if the velocity of the wave front that triggers the attractive interaction is of the same order of magnitude as the time scale defined by the aggregation speed.

  19. Self-diffusion in a dense magnetized plasma

    NARCIS (Netherlands)

    Cohen, J.S.; Suttorp, L.G.

    1984-01-01

    Self-diffusion through dense classical one-component plasmas in a uniform magnetic field is studied by means of renormalized kinetic theory. Extensions of the Landau and the Rostoker equations to plasmas of high density are derived. The coefficient of self-diffusion along the magnetic field is evalu

  20. Cerebellar Granule Cells: Dense, Rich and Evolving Representations

    NARCIS (Netherlands)

    Badura, Aleksandra; De Zeeuw, Chris I

    2017-01-01

    For half a century it was assumed that granule cells use ultra-sparse encoding, but now in vivo calcium-imaging studies have shown that large ensembles of granule cells provide dense signals, which themselves evolve and adapt during training.

  1. Formation and liquid permeability of dense colloidal cube packings

    NARCIS (Netherlands)

    Castillo, Sonja I R; Thies-Weesie, Dominique M E; Philipse, Albert P.

    2015-01-01

    The liquid permeability of dense random packings of cubic colloids with rounded corners is studied for solid hematite cubes and hollow microporous silica cubes. The permeabilities of these two types of packings are similar, confirming that the micropores in the silica shell of the hollow cubes do

  2. Multi-scaling of the dense plasma focus

    Science.gov (United States)

    Saw, S. H.; Lee, S.

    2015-03-01

    The dense plasma focus is a copious source of multi-radiations with many potential new applications of special interest such as in advanced SXR lithography, materials synthesizing and testing, medical isotopes and imaging. This paper reviews the series of numerical experiments conducted using the Lee model code to obtain the scaling laws of the multi-radiations.

  3. Group 2 Pulmonary Hypertension: Pulmonary Venous Hypertension: Epidemiology and Pathophysiology.

    Science.gov (United States)

    Clark, Craig B; Horn, Evelyn M

    2016-08-01

    Pulmonary hypertension from left heart disease (PH-LHD) is the most common form of PH, defined as mean pulmonary artery pressure ≥25 mm Hg and pulmonary artery wedge pressure ≥15 mm Hg. PH-LHD development is associated with more severe left-sided disease and its presence portends a poor prognosis, particularly once right ventricular failure develops. Treatment remains focused on the underlying LHD and despite initial enthusiasm for PH-specific therapies, most studies have been disappointing and their routine clinical use cannot be recommended. More work is urgently needed to better understand the pathophysiology underlying this disease and to develop effective therapeutic strategies. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Clinical worsening after pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension.

    Science.gov (United States)

    Schölzel, B; Snijder, R; Morshuis, W; Saouti, N; Plokker, T; Post, M

    2011-12-01

    Pulmonary endarterectomy (PEA) is the most effective treatment for chronic thromboembolic pulmonary hypertension (CTEPH). The aim of this study is to evaluate long-term survival and freedom from clinical worsening after PEA. All patients who underwent PEA in our hospital between May 2000 and August 2009 were included. Follow-up parameters were all-cause mortality and time to clinical worsening, defined as a combination of death, need for pulmonary hypertension-specific medication or 15% decrease in six-minute walk distance without improvement in functional class. The Cox proportional hazard regression was used to identify predictors. Seventy-four consecutive patients (mean age 55.9 ± 13.8 years, 51% female) underwent PEA. Prior to surgery, 55 patients were in NYHA functional class III or higher. The mean pulmonary artery pressure was 41.3 ± 11.9 mmHg with a mean pulmonary vascular resistance of 521 ± 264 dyn·s·cm(-5) (range 279-1331 dyn·s·cm(-5)). Five patients (6.8%) died in-hospital. Out of hospital, 5 out of 69 patients (7.2%) died during a median follow-up of 3.7 ± 2.2 years [range 0.1-8.5 years]). The one- and five-year survival rates were 93% and 89%, respectively. During follow-up, clinical worsening occurred in 13 out of 69 patients (18.8%). The one- and five-year rates of freedom from clinical worsening were 94% and 72%, respectively. The baseline NT-pro BNP level tended to be a predictor for occurrence of clinical worsening. Pulmonary endarterectomy is associated with good long-term survival in patients with CTEPH. However, clinical worsening occurred in a substantial number of patients at long-term follow-up.

  5. AEROBIC EXERCISE IN PULMONARY REHABILITATION

    Directory of Open Access Journals (Sweden)

    Thiago Brasileiro de Vasconcelos

    2013-05-01

    Full Text Available The aim of this study was to conduct a literature review on the usefulness of aerobic exercise in pulmonary rehabilitation. This is an exploratory study of literature through the electronic databases Medline, Lilacs, Scielo, Pubmed and Google Scholar, published between 1996 and 2012, conducted during the period February to May 2012 with the following keywords: COPD, pulmonary rehabilitation, aerobic exercises, physical training, quality of life. The change in pulmonary function and dysfunction of skeletal muscles that result in exercise intolerance and reduced fitness and may cause social isolation, depression, anxiety and addiction. The training exercise is the most important component of the program of pulmonary rehabilitation where the aerobic training provides consistent results in clinical improvement in levels of exercise tolerance and decreased dyspnea generating more benefits to the body, reducing the chance of cardiovascular disease and improves quality and expectation of life. We demonstrated that the use of aerobic exercise in pulmonary rehabilitation program, allows an improvement of motor skills, decreased muscle fatigue and deconditioning, reducing sedentary lifestyle; however, has little or no effect on the reduction of strength and atrophy muscle.

  6. Aerobic exercise in pulmonary rehabilitation

    Directory of Open Access Journals (Sweden)

    Thiago Brasileiro de Vasconcelos

    2013-01-01

    Full Text Available The aim of this study was to conduct a literature review on the usefulness of aerobic exercise in pulmonary rehabilitation. This is an exploratory study of literature through the electronic databases Medline, Lilacs, Scielo, Pubmed and Google Scholar, published between 1996 and 2012, conducted during the period February to May 2012 with the following keywords: COPD, pulmonary rehabilitation, aerobic exercises, physical training, quality of life. The change in pulmonary function and dysfunction of skeletal muscles that result in exercise intolerance and reduced fitness and may cause social isolation, depression, anxiety and addiction. The training exercise is the most important component of the program of pulmonary rehabilitation where the aerobic training provides consistent results in clinical improvement in levels of exercise tolerance and decreased dyspnea generating more benefits to the body, reducing the chance of cardiovascular disease and improves quality and expectation of life. We demonstrated that the use of aerobic exercise in pulmonary rehabilitation program, allows an improvement of motor skills, decreased muscle fatigue and deconditioning, reducing sedentary lifestyle; however, has little or no effect on the reduction of strength and atrophy muscle.

  7. Cancer incidence in pulmonary vasculitis.

    Science.gov (United States)

    Zycinska, Katarzyna; Kostrzewa-Janicka, Jolanta; Nitsch-Osuch, Aneta; Wardyn, Kazimierz

    2013-01-01

    Pulmonary vasculitis is a potentially lethal autoimmune disease characterized by granulomatous inflammation of respiratory tract, necrotizing vasculitis affecting small-to medium-size vessels and antineutrophil cytoplasmic antibodies elevation. Typical therapy involves high-dose glucocorticosteroids combined with cyclophosphamide in a dose 1-2 mg/kg/per day. A high relapse rate in pulmonary vasculitis means prolonged courses of cyclophosphamide in some patients. Carcinogenic effects of cyclophosphamide, especially its toxic metabolite acrolein that is excreted into the urine, are responsible for the development of acute myeloid leukemia (AML) and bladder cancer. These and other malignancies are cyclophosphamide dose-depended. The aim of the present study was to assess the incidence of cancer in patients with pulmonary vasculitis in comparison with the incidence of cancer in the general population. Analyses were done according to the cumulative dose of cyclophosphamide, subdivided into low (≤35 g) and high (>35 g). During the observation period 15 cancers occurred. A significantly increased standardized incidence ratio (SIR) was observed for non-melanoma skin cancers (SIR 5.2; 95 % Cl 2.3-8.7), AML (SIR 4.3; 95 % Cl 2.1-11.2), and bladder cancer (SIR 3.4; 95 % Cl 1.6-5.2). Induction remission treatment and relapse treatment with cyclophosphamide involves a substantial risk of late appearing malignances in patients with pulmonary vasculitis. Monitoring and prophylactic management in pulmonary vasculitis after cessation of cyclophosphamide therapy is crucial.

  8. Fever in acute pulmonary embolism.

    Science.gov (United States)

    Stein, P D; Afzal, A; Henry, J W; Villareal, C G

    2000-01-01

    Although fever has been reported in several case series of acute pulmonary embolism (PE), the extent to which fever may be caused by PE, and not associated disease, has not been adequately sorted out. Clarification of the frequency and severity of fever in acute PE may assist in achieving an accurate clinical impression, and perhaps avoid an inadvertent exclusion of the diagnosis. The purpose of this investigation is to evaluate the extent to which fever is caused by acute PE. Patients participated in the Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED). Temperature was evaluated among patients with angiographically proven PE. A determination of whether other causes of fever were present was based on a retrospective analysis of discharge summaries, PIOPED summaries, and a computerized list of all discharge diagnoses. Among patients with PE and no other source of fever, fever was present in 43 of 311 patients (14%). Fever in patients with pulmonary hemorrhage or infarction was not more frequent than among those with no pulmonary hemorrhage or infarction, 39 of 267 patients (15%) vs 4 of 44 patients (9%; not significant). Clinical evidence of deep venous thrombosis was often present in patients with PE and otherwise unexplained fever. Low-grade fever is not uncommon in PE, and high fever, although rare, may occur. Fever need not be accompanied by pulmonary hemorrhage or infarction.

  9. Long-term visual outcome of dense bilateral congenital cataract

    Institute of Scientific and Technical Information of China (English)

    YE He-hua; DENG Da-ming; QIAN Yi-yong; LIN Zhi; CHEN Wei-rong

    2007-01-01

    Background Dense congenital cataracts often cause severe visual impairment. The results of long-term follow-up of dense bilateral congenital cataract in China have not been well documented. The purpose of this study was to evaluate the long-term visual function in children who underwent cataract extraction for dense bilateral congenital cataract in southern part of China.Methods Medical records of children who underwent surgery of dense bilateral congenital cataract between January 1992 and December 2000 at Zhongshan Ophthalmic Center of Sun Yat-sen University were retroactively reviewed. In 38 children available for current follow-up, best corrected visual acuity (BCVA) and stereoscopic vision, as well as nystagmus, strabismus, and other complications, were evaluated. The mean follow-up period was 107.6 months (range 60 to 167 months).Results The mean age of cataract extraction and secondary intraocular lens implantation were 5.6 months (range 3 to 12 months) and 4.2 years (range 2.4 to 15 years), respectively. The mean BCVA was 0.25 in the better eye and 0.16 in the fellow eye. Stereoscopic vision was absent in all patients, and 3 children had simultaneous perception. Nystagmus was detected in all cases and strabismus in 35 cases. A high correlation was found between timing of cataract extraction and final BCVA of the better eye (r=-0.55, P=0.00). A statistically significant difference was found in BCVA between postand pre-treatment of amblyopia (t=5.65, P=0.00).Conclusions Long-term visual function in children with dense bilateral congenital cataract was poor when cataract surgery was performed at age of 3 months or later. Earlier cataract surgery with adequate optical rehabilitation contributed to better visual outcome.

  10. Ventilation-Perfusion Relationships Following Experimental Pulmonary Contusion

    Science.gov (United States)

    2007-06-14

    new method for assessment of pulmo- nary density distributions involving semiautomatic 3-dimensional reconstruction of chest computed tomography (CT...hemorrhage, alveolar edema, inflammation, and necrosis, each graded on a scale of 0 through 4 (0 normal, 1 minimal, 2 mild, 3 moderate, 4...in the left lungs of the injured animals were mild and consisted of patchy ground- glass opacification (Fig. 6). Semiautomatic CT scan analysis

  11. Study on the pulmonary mean transit time and the pulmonary blood volume by RI-cardiogram

    Energy Technology Data Exchange (ETDEWEB)

    Ushio, N.

    1987-03-01

    The pulmonary mean transit time and the pulmonary blood volume in cases of cardio-pulmonary disease were measured using Giuntini's method which is considered the most appropriate among radiocardiographic methods. The errors in this method were confirmed to be almost negligible. The results obtained were as follows: 1) The pulmonary mean transit time was related to the systemic mean transit time and markedly prolonged in left heart failure. On the other hand, it was markedly shortened in some cases of chronic pulmonary disease, particularly pulmonary emphysema. 2) The pulmonary blood volume tended to increase in left heart disorders and mitral valve disease and tended to decrease in the chronic pulmonary disease. The decrease was conspicuous particularly in some cases of pulmonary emphysema. 3) A structural change of the pulmonary vascular system in the chronic pulmonary disease appeared to bring about shortening of the pulmonary mean transit time and a decrease in the pulmonary blood volume. The pathophysiology of cardio-pulmonary disease can be more clarified by the RI-cardiogram used in this study, in which the pulmonary mean transit time and the pulmonary blood volume are used as the indicator.

  12. Pulmonary agenesis and pulmonary sling anomaly in an infant with Down syndrome.

    Science.gov (United States)

    Takci, S; Yigit, S; Haliloglu, M; Boduroglu, K; Kiper, N

    2013-01-01

    Pulmonary agenesis is a rare congenital anomaly presenting with normal karyotype in most of the cases. Rarely pulmonary agenesis is associated with chromosomal abnormalities and other genetic disorders such as Oculo-auriculo-vertebral spectrum, VACTERL association and velo-cardio-facial syndrome. This report presents a patient with pulmonary agenesis, pulmonary sling anomaly and Down syndrome.

  13. Congenital diaphragmatic hernia-associated pulmonary hypertension.

    Science.gov (United States)

    Harting, Matthew T

    2017-06-01

    Congenital diaphragmatic hernia (CDH) is a complex entity wherein a diaphragmatic defect allows intrathoracic herniation of intra-abdominal contents and both pulmonary parenchymal and vascular development are stifled. Pulmonary pathology and pathophysiology, including pulmonary hypoplasia and pulmonary hypertension, are hallmarks of CDH and are associated with disease severity. Pulmonary hypertension (PH) is sustained, supranormal pulmonary arterial pressure, and among patients with CDH (CDH-PH), is driven by hypoplastic pulmonary vasculature, including alterations at the molecular, cellular, and tissue levels, along with pathophysiologic pulmonary vasoreactivity. This review addresses the basic mechanisms, altered anatomy, definition, diagnosis, and management of CDH-PH. Further, emerging therapies targeting CDH-PH and PH are explored. Published by Elsevier Inc.

  14. Sickle Cell Disease and Pulmonary Hypertension

    Science.gov (United States)

    ... My doctor wants to screen me for pulmonary hypertension. Why is this? Sickle cell disease (SCD), a ... What are some of the symptoms of pulmonary hypertension? Because they are somewhat general symptoms, the characteristics ...

  15. What To Expect During Pulmonary Rehabilitation

    Science.gov (United States)

    ... NHLBI on Twitter. What To Expect During Pulmonary Rehabilitation Pulmonary rehabilitation (PR) can have many parts, and not all ... back over and over with his or her hands cupped. This loosens the mucus from your lungs ...

  16. Effects of posture on postoperative pulmonary function

    DEFF Research Database (Denmark)

    Nielsen, K G; Holte, Kathrine; Kehlet, H

    2003-01-01

    effect on postoperative pulmonary function in the sitting or standing position compared with the supine. Thus, avoidance of the supine position may improve postoperative pulmonary function. Three of six studies showed a positive effect on postoperative pulmonary function of the lateral side compared......BACKGROUND: Pulmonary morbidity is still a relevant complication to major surgery despite improvements in surgical technique and anaesthetic methods. Postoperative posture may be a pathogenic factor, but the effects of changes in postoperative posture on pulmonary function have not been reviewed...... with the supine. Thus, the lateral position has limited effects on pulmonary function. CONCLUSION: Changes of postoperative position from supine to sitting or standing are of major importance in the interpretation of postoperative pulmonary outcome studies and in future strategies to improve pulmonary outcome....

  17. Diffuse pulmonary infiltrates in immunocompromised patients

    NARCIS (Netherlands)

    Fijen, JW; van der Werf, TS; Ligtenberg, JJM; Tulleken, JE; Zijlstra, JG

    1999-01-01

    The differential diagnosis of bilateral interstitial pulmonary infiltrates in immunocompromised patients is very extensive. We describe two immunocompromised patients with diffuse pulmonary infiltrative changes. Bronchoscopic bronchoalveolar lavage after orotracheal intubation using topical anaesthe

  18. Nutritional supplementation in patients with chronic obstructive pulmonary disease.

    Science.gov (United States)

    Hsieh, Meng-Jer; Yang, Tsung-Ming; Tsai, Ying-Huang

    2016-08-01

    Malnutrition in patients with chronic obstructive pulmonary disease (COPD) is associated with cachexia, sarcopenia, and weight loss, and may result in poorer pulmonary function, decreased exercise capacity, and increased risk of exacerbations. Providing nutritional supplementation is an important therapeutic intervention, particularly for severely ill COPD patients with malnutrition. Higher calorie intake through nutritional supplementation significantly increases body weight and muscle strength, and improves quality of life in malnourished COPD patients. Difficulties may be experienced by these COPD patients, who are struggling to breathe and eliminate CO2 from the lungs, resulting in dyspnea, hypercapnia, hypoxia, and respiratory acidosis, which exacerbates muscle loss through oxidative stress and inflammatory responses. To overcome these problems, nutritional supplements should aim to reduce metabolic CO2 production, lower respiratory quotient, and improve lung function. Several studies have shown that high-fat supplements produce less CO2 and have lower respiratory quotient value than high-carbohydrate supplements. In addition, high-fat supplements may be the most efficient means of providing a low-volume, calorie-dense supplement to COPD patients, and may be most beneficial to patients with prolonged mechanical ventilation where hypercapnia and malnutrition are most pronounced. Further studies are required to investigate the optimal nutritional supplements for COPD patients according to their disease severity. Copyright © 2015. Published by Elsevier B.V.

  19. 离体培养晶状体囊袋模型在后囊膜混浊相关研究中的应用%Applications of capsular bag model in posterior capsular opacification

    Institute of Scientific and Technical Information of China (English)

    张春梅; 靳娜

    2016-01-01

    Posterior capsular opacification (PCO),also known as after-cataract,is the most frequent complication and the primary cause for visual decrease after extracapsular cataract surgery.At present,there is no effective way to treat PCO,so more attentions are focused on preventive reseaching of PCO and treatment methods.Although a variety of studies have increased our understanding of the pathogenesis of PCO,the cellular mechanisms responsible for PCO are still unclear.Cultured capsular bag model in vitro could effectively simulate lens capsular membrane and cells survival environment after cataract extraction and IOL implantation.However,lens capsular bag cultivation with different methods have their own characreristics.The material source,preparation methods of capsular bag model,characreristics of materials which maintain capsular bag contours and its application in PCO were reviewed.%晶状体后囊膜混浊(PCO)又称后发性白内障,是白内障囊外摘出术后最常见的并发症,也是术后远期视力下降的主要原因,目前尚无有效的治疗方法,因此寻找切实有效防治PCO的方法备受眼科工作者的关注.长期以来研究者多通过单纯培养LECs来探索PCO发生和发展的机制,虽然加深了我们对其发病机制的了解,但其发生的细胞机制仍不清楚.随着广大眼科学者对PCO发病机制不断的研究和探索,通过体外培养晶状体囊袋模型,能够较为真实地模拟白内障术后晶状体囊膜及细胞生存的环境,便于更好地观察术后在模拟体外微环境下晶状体囊膜及细胞的生物学行为变化规律.本文就囊袋模型的种属来源及其特点、囊袋制备所采用的不同方式及其优缺点、维持囊袋轮廓所采用的不同材料及特点、囊袋模型与在体动物模型相比其具有的优缺点及囊袋模型在PCO相关研究中的应用进行简述.

  20. Pulmonary arterial hypertension and pregnancy

    Directory of Open Access Journals (Sweden)

    Demet Terek

    2013-01-01

    Full Text Available This is the case report of a pregnant woman who refused pregnancy termination when diagnosed with pulmonary arterial hypertension (PAH functional class 2-3 at the 24th week of gestation and of her newborn. A pregnant woman with PAH functional class 2-3 was treated with inhaled prostacyclin analog (iloprost, oral sildenafil, oxygen, and low molecular weight heparin. She delivered at 32nd week by Cesarean section. The infant required oxygen up to 36th week postconceptional age and had a short steroid treatment. The mother needed close cardiovascular monitorization, intensive oxygen and pulmonary vasodilator therapy for 2 months and was discharged with oxygen and oral iloprost treatment. A multidisciplinary approach together with pulmonary vasodilator therapy may be succesful in such a high-risk pregnant woman.

  1. Epidemiology of idiopathic pulmonary fibrosis

    Directory of Open Access Journals (Sweden)

    Ley B

    2013-11-01

    Full Text Available Brett Ley, Harold R Collard Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, California, USA Abstract: Idiopathic pulmonary fibrosis is a chronic fibrotic lung disease of unknown cause that occurs in adults and has a poor prognosis. Its epidemiology has been difficult to study because of its rarity and evolution in diagnostic and coding practices. Though uncommon, it is likely underappreciated both in terms of its occurrence (ie, incidence, prevalence and public health impact (ie, health care costs and resource utilization. Incidence and mortality appear to be on the rise, and prevalence is expected to increase with the aging population. Potential risk factors include occupational and environmental exposures, tobacco smoking, gastroesophageal reflux, and genetic factors. An accurate understanding of its epidemiology is important, especially as novel therapies are emerging. Keywords: idiopathic pulmonary fibrosis, epidemiology, incidence, prevalence, mortality, risk factors

  2. [Pulmonary hypertension caused by left heart disease].

    Science.gov (United States)

    Erer, Betül; Eren, Mehmet

    2010-09-01

    Increased resistance to pulmonary venous drainage is the main mechanism in pulmonary hypertension (PH) developing due to left heart disease. This condition may occur as a result of various diseases affecting left ventricle, left atrium, mitral or aortic valves. Pulmonary hypertension is the common and well-recognized complication of left ventricular systolic dysfunction and pulmonary arterial hypertension accompanying chronic heart failure is related to increased mortality. Treatment should be tailored according to the underlying disease.

  3. CT "halo sign" in pulmonary tuberculoma.

    Science.gov (United States)

    Gaeta, M; Volta, S; Stroscio, S; Romeo, P; Pandolfo, I

    1992-01-01

    The CT halo sign has been described as the CT finding of a low-attenuation zone surrounding a pulmonary nodule. It is an early clue to the diagnosis of invasive pulmonary aspergillosis. We describe a case of CT halo sign associated with a pulmonary tuberculoma. Therefore, we think that a diagnosis other than invasive pulmonary aspergillosis should be considered in the presence of the CT halo sign in immunocompetent patients.

  4. Multiple coarctation of the pulmonary artery

    Energy Technology Data Exchange (ETDEWEB)

    Dicle, Oguz; Yilmaz, Erkan E-mail: eyilmaz@kordon.deu.edu.tr

    2000-12-01

    Pulmonary artery coarctation is a rare congenital anomaly characterized by single or multiple stenoses of the pulmonary arteries and their branches. There are only a few reports describing the radiological film of this entity. In this paper we report the case of a 68 year-old woman who presented with dyspnea. The scintigraphic, examination of the lungs gave the misleading impression of pulmonary embolism, and only angiography and magnetic resonance imaging established the correct diagnosis of multiple coarctations of the pulmonary artery.

  5. Pulmonary Complications due to Esophagectomy

    Directory of Open Access Journals (Sweden)

    Yashar Talebi

    2011-08-01

    Full Text Available Introduction: Esophageal carcinoma is the scourge of human beings. Pulmonary compli-cations in patients who have undergone operation are common (20-30% of cases and there are no suitable tools and ways to predict these complications. Methods: During a period of 10 years, from March 1998 to February 2007, 200 patients (150 male and 50 female underwent Esophagectomy due to esophageal carcinoma in thoracic surgery ward retrospectively. Complications include the length of hospitalization, mechanical ventilation, morbidity and mortality. Patients’ risk factors include age, preoperative chemo-radiotherapy, stage of the disease and preoperative spirometry condition. Results: We grouped our patients into three categories: Normal (FEV1 ≥ 80% predicted, mildly impaired (FEV1 65% to 79% predicted, more severely impaired (FEV1 < 65% predicted.Although almost all patients had radiographic pulmonary abnormalities, significant pulmonary complications occurred in 40 patients (20% which underwent Esophagectomy. Pleural effusion and atelectasia in 160 patients (80%. 24 patients needed chest-tube insertion. 20 patients (10% developed ARDS. 14 patients (7% developed chylothorax. 20 patients (10% of patients died during their postoperative hospital stay. 30 patients (15% required mechanical ventilation for greater than 48 hours. Conclusion: We reviewed a number of preoperative clinical variables to determine whether they contributed to postoperative pulmonary complications as well as other outcomes. In general, age, impaired pulmonary function especially in those patients with FEV1 less than 65% predicted was associated with prolonged hospital length of stay (LOS. In fact pulmonary complications rate after Esophagectomy are high and there was associated mortality and morbidity.

  6. Amiodarone pulmonary toxicity: Case report

    Directory of Open Access Journals (Sweden)

    Vasić Nada

    2014-01-01

    Full Text Available Introduction. Amiodarone, an antiarrhythmic drug, which contains iodine compound, has a tendency to accumulate in some organs including the lungs. This is age, drug dosage and therapy duration dependent. Case Outline. We present a case of a 73-year-old man, a smoker, who was admitted as emergency case due to severe dyspnea, tachypnea with signs of cyanosis and respiratory insufficiency. Chest x-ray revealed bilateral diffuse pulmonary shadows in the middle and upper parts of the lungs, similar to those in tuberculosis. His illness history showed chronic obstructive pulmonary disease, arterial hypertension, and atrial fibrillation which has been treated with amiodarone for six years. Sputum smears were negative for mycobacteria, and by the diagnostic elimination method for specific, non-specific and malignant disease the diagnosis of amiodarone pulmonary toxicity was made. Fiberoptic bronchoscopy and pathohistological findings of bronchiolitis obliterans organizing pneumonia confirmed the diagnosis. As the first therapeutic approach, amiodarone therapy was stopped. Then, systemic therapy with methylprednisolone 21 (sodium succinate 40 mg i.v. daily during the first two weeks was initiated and continued with daily dose of methylprednisolone 30 mg orally during the next three months. The patient showed a marked subjective improvement during the first week, which was followed by the improvement of respiratory function and withdrawal of pulmonary changes with complete radiographic and CT resolution after eight months. Conclusion. Amiodarone pulmonary toxicity should be taken into consideration, especially in elderly patients with respiratory symptoms and pulmonary changes, even if only a low dose of amiodarone is administred over a longer time period.

  7. Pulmonary mucormycosis presenting with vocal cord paralysis

    OpenAIRE

    Gayathri Devi, H. J.; Mohan Rao, K.N.; K M Prathima; Moideen, Riyaz

    2013-01-01

    Pulmonary mucormycosis is a relatively uncommon infection. It can present in various forms. Very few cases of pulmonary mucormycosis presenting as vocal cord paralysis have been described in the literature. We report a case of pulmonary mucormycosis presenting as vocal cord paralysis in an uncontrolled diabetic patient.

  8. Multiple pulmonary hamartomas: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Chang Woo; Kim, Jeung Sook; Lee, Hyeon Jae; Lee, Yong Hee [Pochon CHA Univ. College of Medicine, Sungnam (Korea, Republic of)

    1999-07-01

    Hamartomas are the most common benign neoplasms of the lung. However, multiple pulmonary hamartomas are very rare. We describe the radiographic findings of multiple pulmonary hamartomas without Carney's or pulmonary hamartoma syndrome with review the literature describing to this entity.

  9. Pulmonary Function Tests: Are They Really Necessary?

    OpenAIRE

    Rosenal, T.; Ford, G.T.

    1989-01-01

    Pulmonary function tests and clinical evaluation can complement one another, but neither can take the place of the other. The tests can provide objective, reproducible assessment of a patient's pulmonary status. Pulmonary function tests can support clinical diagnoses, quantify the severity and variability of the disorder, and can assist early intervention by indicating problems likely to arise later in the course of the disease.

  10. Pulmonary complications of upper abdominal surgery.

    Directory of Open Access Journals (Sweden)

    Deodhar S

    1991-04-01

    Full Text Available Pulmonary complications encountered in 67 patients undergoing upper abdominal surgery in our unit in one year period are analysed. Pulmonary function tests and their post-operative reduction, as also the risk factors are discussed. Pathophysiology responsible for pulmonary complications is outlined.

  11. Lutembacher Syndrome and Rheumatic Pulmonary Stenosis

    Institute of Scientific and Technical Information of China (English)

    Jufang Chi; Hangyuan Guo; Biao Yang

    2008-01-01

    We discdbed a case of a 55-yr-old woman diagnosed with Lutembacher syndrome and rheumatic pulmonary stenosis.Congenital atrial septal defect was found in age 7 and rheumatic fever in age 34.As the patient developed pulmonary hypertension with calcified mitral valve leaflet and pulmonary stenosis so surgery was not indicated.So the patient was managed by medical therapy alone.

  12. Flail chest and pulmonary contusion.

    Science.gov (United States)

    Bastos, Renata; Calhoon, John H; Baisden, Clinton E

    2008-01-01

    Flail chest is most often accompanied by a significant underlying pulmonary parenchymal injury and can be a life-threatening thoracic injury. Its management is often complicated by the other injuries it is frequently associated with. Similarly, mortality and morbidity are dictated most often by the associated injuries and findings. Its treatment is complex and should first be one of pain management, judicious fluid resuscitation, and excellent pulmonary toilet. In those patients requiring mechanical ventilatory support, or who require ipsilateral thoracocotomy, rib stabilization may be considered depending on a host of potentially conflicting indications and contraindications. At the end of this section are listed the current major recommendations and their levels of evidence.

  13. [Special beds. Pulmonary therapy system].

    Science.gov (United States)

    Calixto Rodríguez, Joaquín; Rodríguez Martínez, Xavier; Marín i Vivó, Gemma; Paunellas Albert, Josep

    2008-10-01

    To be bedridden reduces one's capacity to move and produces muscular debility that affects the respiratory system leading to a decreased effectiveness in expectoration, the ability to spit up sputum. The pulmonary therapy system integrated in a bed is the result of applying motorized elements to the articulation points of the bad in order to achieve safe positions at therapeutic angles, which improve the breathing-perfusion (blood flow) relationship. This system also makes it possible to apply vibration waves to the patient which favor the elimination of bronchial-pulmonary secretions, the rehabilitation of the bedridden patient and decrease the work load for nursing personnel.

  14. Program organization in pulmonary rehabilitation.

    Science.gov (United States)

    Garvey, Chris; Carlin, Brian; Raskin, Jonathan

    2014-06-01

    Variable aspects of pulmonary rehabilitation (PR) programs include staff composition, setting, structure, and duration. Longer PR programs generally translate into greater improvements in outcomes and (perhaps) prolonged maintenance of benefits. Barriers to PR include transportation issues, inconvenience for the patient, cost and insurance coverage problems, lack of perceived benefit, concurrent illness, and influence of the provider. PR settings include inpatient and outpatient environments. PR has been shown to improve health care utilization during or immediately following chronic obstructive pulmonary disease exacerbations. Challenges to providing PR may be partially addressed by technological developments.

  15. Pulmonary coccidioidomycosis : a case report

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Yong Soo; Lee, Jin Seong; Kim, Hyae Young; Song, Koun Sik; Sohn, Kwang Hyun; Lim, Tae Hwan [Asan Medical Center, Ulsan Univ. College of Medicine, Seoul (Korea, Republic of)

    1999-04-01

    A 72-year-old woman was admitted due to a solitary pulmonary nodule incidentally found after routine chest radiography. Chest CT showed a solitary pulmonary nodule without calcification in the right upper lobe. Three years earlier, she had spent 3 months in Arizona. Surgical resection was performed after percutaneous transthoracic fine needle aspiration had suggested malignaney. The lesion was caseous and necrotic, and histologic examination indicated the presence of endosporulating spherules. We report a case of coccidioidomycosis which was resected in order to rule out lung cancer.

  16. Sympathetic crashing acute pulmonary edema.

    Science.gov (United States)

    Agrawal, Naman; Kumar, Akshay; Aggarwal, Praveen; Jamshed, Nayer

    2016-12-01

    Sympathetic crashing acute pulmonary edema (SCAPE) is the extreme end of the spectrum of acute pulmonary edema. It is important to understand this disease as it is relatively common in the emergency department (ED) and has better outcomes when managed appropriately. The patients have an abrupt redistribution of fluid in the lungs, and when treated promptly and effectively, these patients will rapidly recover. Noninvasive ventilation and intravenous nitrates are the mainstay of treatment which should be started within minutes of the patient's arrival to the ED. Use of morphine and intravenous loop diuretics, although popular, has poor scientific evidence.

  17. Reexpansion pulmonary edema following thoracentesis

    Directory of Open Access Journals (Sweden)

    Ansuman Mukhopadhyay

    2016-01-01

    Full Text Available Reexpansion pulmonary edema is an uncommon complication of the treatment of lung atelectasis, pleural effusion or pneumothorax and pathogenesis is unknown. An elderly male patient presented to us with right-sided pleural effusion. 2 h after thoracentesis, he felt chest discomfort and increased breathlessness. His chest examination showed right-sided crackles. Chest radiograph showed right-sided heterogeneous opacity in right lower zone consistent with unilateral pulmonary edema. He was managed conservatively along with bilevel positive airway pressure ventilator support. His condition improved gradually and was discharged successfully after 2 days.

  18. A case of left main pulmonary artery aneurysm associated with valvular pulmonary stenosis in a child.

    Science.gov (United States)

    Lee, Ran; Son, Jae Sung; Park, Yong Mean

    2011-10-01

    Aneurysm of the main pulmonary artery is a rare clinical entity that can be congenital or acquired. Most cases occur in association with other congenital malformations, severe pulmonary hypertension, vasculitides, infectious agents, or collagen vascular disorders. We report here a pediatric case of left pulmonary artery aneurysm associated with valvular pulmonary stenosis and a hypoplastic right pulmonary artery, which we confirmed via multidetector computed tomography angiography.

  19. Model studies of dense water overflows in the Faroese Channels

    Science.gov (United States)

    Cuthbertson, Alan; Davies, Peter; Stashchuk, Nataliya; Vlasenko, Vasiliy

    2014-01-01

    The overflow of dense water from the Nordic Seas through the Faroese Channel system was investigated through combined laboratory experiments and numerical simulations using the Massachusetts Institute of Technology General Circulation Model. In the experimental study, a scaled, topographic representation of the Faroe-Shetland Channel, Wyville-Thomson Basin and Ridge and Faroe Bank Channel seabed bathymetry was constructed and mounted in a rotating tank. A series of parametric experiments was conducted using dye-tracing and drogue-tracking techniques to investigate deep-water overflow pathways and circulation patterns within the modelled region. In addition, the structure of the outflowing dense bottom water was investigated through density profiling along three cross-channel transects located in the Wyville-Thomson Basin and the converging, up-sloping approach to the Faroe Bank Channel. Results from the dye-tracing studies demonstrate a range of parametric conditions under which dense water overflow across the Wyville-Thomson Ridge is shown to occur, as defined by the Burger number, a non-dimensional length ratio and a dimensionless dense water volume flux parameter specified at the Faroe-Shetland Channel inlet boundary. Drogue-tracking measurements reveal the complex nature of flow paths and circulations generated in the modelled topography, particularly the development of a large anti-cyclonic gyre in the Wyville-Thompson Basin and up-sloping approach to the Faroe Bank Channel, which diverts the dense water outflow from the Faroese shelf towards the Wyville-Thomson Ridge, potentially promoting dense water spillage across the ridge itself. The presence of this circulation is also indicated by associated undulations in density isopycnals across the Wyville-Thomson Basin. Numerical simulations of parametric test cases for the main outflow pathways and density structure in a similarly-scaled Faroese Channels model domain indicate excellent qualitative agreement with

  20. 高透氧硬性角膜接触镜对外伤性角膜浑浊合并无晶状体眼的矫治%Clinical effect of rigid gas permeable contact lens for traumatic aphakic eye with cornel opacification

    Institute of Scientific and Technical Information of China (English)

    刘立洲; 吕燕云; 彭丽

    2011-01-01

    目的 探讨高透氧硬性角膜接触镜(RGPCL)对外伤性角膜浑浊合并无晶状体眼的矫治效果。方法 对外伤性角膜浑浊合并无晶状体眼439例(441眼)配戴RGPCL,随诊5年,比较插片视力与RGPCL的矫正视力;随访5年观察配戴RGPCL角膜内皮改变情况。结果 外伤性角膜浑浊合并无晶状体眼的插片视力和配戴RGPCL的矫正视力分别为0.47±0.22和0.69±0.21,(P<0.0005),差异有统计学意义。配戴RGPCL比插片能获得更好的矫正视力。角膜内皮计数5年后无明显改变。结论 RGPCL对外伤性角膜浑浊合并无晶状体眼有较好的矫正视力,对角膜内皮代谢无明显影响。%Objective To investigate the clinical effect of rigid gas permeable contact lens (RGPCL) for traumatic corneal opacification and cataract. Methods 439 patients(441 eyes) with traumatic corneal opacification and cataract were fitted with RGPCL and followed up for 5 years. The difference of the corrected vision was compared between RGPCL group and glasses group. Followed up for 5 years, the corneal endothelial changes were observed. Results The mean corrected vision with glasses and with RGPCL were (0.47 ± 0.22 ) and (0.69 ± 0.21 ) ( P < 0. 0005 ). The patients with RGPCL got better corrected vision than those with glasses. There were not significant changes in the corneal endothelial cells. Conclusion The RGPCL is safe and effective for the patients with traumatic corneal opacification and cataract. The patients can get good corrected vision.