Economic and Environmental Evaluation of a Brick Delivery System Based on Multi-Trip Vehicle Loader Routing Problem for Small Construction Sites

Directory of Open Access Journals (Sweden)

Heungjo An

2018-05-01

Full Text Available While large construction sites have on-site loaders to handle heavy and large packages of bricks, small brick manufacturers employ a truck-mounted loader or sometimes deploy a loader truck to accompany normal brick delivery trucks to small construction sites lacking on-site loaders. It may be very challenging for small contractors to manage a sustainable delivery system that is both cost-effective and environmentally friendly. To address this issue, this paper proposes to solve a multi-trip vehicle loader routing problem by uniquely planning routes and schedules of several types of vehicles considering their synchronized operations at customer sites and multi trips. This paper also evaluates the sustainability of the developed model from both economic and environmental perspectives. Case studies based on small construction sites in the Middle East demonstrate applications of the proposed model to make the most economical plans for delivering bricks. Compared to the single-trip vehicle loader routing problem, the proposed model reduces, on average, 18.7% of the total delivery cost while increasing CO2 emission negligibly. The economic benefit is mainly achieved by reducing the required number of vehicles. Brick plant managers can use the proposed mathematical model to plan the most cost-effective delivery schedules sustainably while minimizing negative environmental effects.

Focal points of environmental policy at the beginning of the Eighties

International Nuclear Information System (INIS)

Anon.

1981-01-01

This speech was held by the Federal Home Secretary Baum in front of the Arbeitsgemeinschaft fuer Umweltfragen (AGU) on 3rd February 1981. He said that environmental policy must be determined even more by the principle of providence in this decade; the main issue is the orientation towards the future in German economic, social, and welfare policy. Vehicles and environment, vehicle noise, advantageous conditions in competition for environmentally-minded and energy conserving vehicles, nuclear energy etc., and international pollution protection are considered focal points of future environmental policy. According to his opinion, the consumption situation and compatibility tests as to environmental conditions are necessary. Increasing pollution protection ought to be promoted by special financing programmes and model projects of the Federal Government. (HSCH) [de

Environmental dew point and skin and lip weathering.

Science.gov (United States)

Devillers, C; Piérard, G E; Quatresooz, P; Piérard, S

2010-05-01

Xerosis represents a physiological response of the stratum corneum (SC) to environmental threats. The influence of the environmental dew point (DP) is not fully understood. This parameter is the air temperature at which the relative humidity is maximum. This study aimed to assess the relationship between the environmental DP and the water-holding capacity of the skin and lower lip vermilion. For comparison, SC property was evaluated after occlusive application of cooled and uncooled hydrogel pads. Electrometric measurements using a dermal phase meter (DPM) device were performed on the back of the hands, the cheeks and the lower lip of 40 healthy menopausal women. Assessments were performed in the outdoor conditions during winter and spring. The same measurements were recorded after hydrogel pads, at room temperature or cooled to 4 degrees C, were placed for 15 min on the test sites. The environmental DP was recorded at each evaluation time. The SC water-holding capacity was discretely influenced by the DP. In the open-air environmental conditions, a positive linear relationship was found on the cheeks between the DP and DPM values. The relationship was weaker on the lips. Conversely, a consistent increase in DPM values was recorded immediately after removal of the cooled and uncooled hydrogel pads. The observations made in the open-air testing conditions are consistent with the predicted events following the Arrhenius law. By contrast, the combination of cooling and occlusion by the hydrogel pads is responsible for the reverse effect on the SC.

The Oil Point Method - A tool for indicative environmental evaluation in material and process selection

DEFF Research Database (Denmark)

Bey, Niki

2000-01-01

to three essential assessment steps, the method enables rough environmental evaluations and supports in this way material- and process-related decision-making in the early stages of design. In its overall structure, the Oil Point Method is related to Life Cycle Assessment - except for two main differences...... of environmental evaluation and only approximate information about the product and its life cycle. This dissertation addresses this challenge in presenting a method, which is tailored to these requirements of designers - the Oil Point Method (OPM). In providing environmental key information and confining itself...

Environmental monitoring report for the Point Lepreau, New Brunswick nuclear generating station 1984

International Nuclear Information System (INIS)

Nelson, R.W.P.; Ellis, K.M.; Smith, J.N.

1986-07-01

The Point Lepreau Environmental Monitoring Program (PLEMP) has been established within the Department of Fisheries and Oceans to assess the environmental impact of radioactive, thermal, and chemical releases from the Point Lepreau, N.B. Nuclear Generating Station (NGS) located on the Bay of Fundy. This report contains the results for the second year of the operational phase of the monitoring program. Emphasis has been placed on those areas where effects from the NGS operation were expected to be observed. Further studies were carried out on the characterization of the thermal plume during several pre-arranged tritium releases. Attention was given to tritium levels at the outfall, in the atmosphere and in biological samples. An initial attempt was made to relate the distribution of tritium in the Point Lepreau area in various phases to local meteorological conditions. Radionuclide levels in lichen, including, for the first time, aerial lichen on a regular basis, an efficient accumulator of atmospheric particulates were monitored. In addition, radionuclide measurements were made on samples collected during the pre-operational phase from the major environmental reservoirs and these radioactivity levels were compared to previous measurements to assess the impact of the operation of the NGS. The purpose of this program is to provide government with a comprehensive scientific basis upon which to assess the environmental implications of the operation of nuclear reactors in coastal regions

Designing and assessing a sustainable networked delivery (SND) system: hybrid business-to-consumer book delivery case study.

Science.gov (United States)

Kim, Junbeum; Xu, Ming; Kahhat, Ramzy; Allenby, Braden; Williams, Eric

2009-01-01

We attempted to design and assess an example of a sustainable networked delivery (SND) system: a hybrid business-to-consumer book delivery system. This system is intended to reduce costs, achieve significant reductions in energy consumption, and reduce environmental emissions of critical local pollutants and greenhouse gases. The energy consumption and concomitant emissions of this delivery system compared with existing alternative delivery systems were estimated. We found that regarding energy consumption, an emerging hybrid delivery system which is a sustainable networked delivery system (SND) would consume 47 and 7 times less than the traditional networked delivery system (TND) and e-commerce networked delivery system (END). Regarding concomitant emissions, in the case of CO2, the SND system produced 32 and 7 times fewer emissions than the TND and END systems. Also the SND system offer meaningful economic benefit such as the costs of delivery and packaging, to the online retailer, grocery, and consumer. Our research results show that the SND system has a lot of possibilities to save local transportation energy consumption and delivery costs, and reduce environmental emissions in delivery system.

77 FR 59601 - Dominion Cove Point LNG, LP; Notice of Intent To Prepare an Environmental Assessment for the...

Science.gov (United States)

2012-09-28

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PF12-16-000] Dominion Cove Point LNG, LP; Notice of Intent To Prepare an Environmental Assessment for the Planned Cove Point Liquefaction Project, Request for Comments on Environmental Issues, Notice of On- Site Environmental Review, and Notice of Public Scoping Meetings The...

Environmental radiation monitoring data for Point Lepreau Generating Station, 1988. Annual publication

Energy Technology Data Exchange (ETDEWEB)

Sutherland, J K

1989-01-01

Annual report presenting a compilation of the 1988 environmental radiation monitoring program data from samples collected around the Point Lepreau Nuclear Generating Station (PLNGS) and at reference stations remote from PLNGS. About 1,700 analyses were made on 1,200 samples to monitor environmental radiation, including air filters, airborne water vapour, sea water, well water, milk, beach sediments, clams, fish, lobster, dulse, crabs, scallops and lichen. Background radiation is measured by thermoluminescence dosimetry.

Environmental radiation monitoring data for Point Lepreau Generating Station, 1987. Annual publication

Energy Technology Data Exchange (ETDEWEB)

Sutherland, J K

1988-01-01

Annual report presenting a compilation of the 1987 environmental radiation monitoring program data from samples collected around the Point Lepreau Nuclear Generating Station (PLNGS) and at reference stations remote from PLNGS. About 1,800 analyses were made on 1,300 samples to monitor environmental radiation, including air filters, airborne water vapour, sea water, well water, milk, beach sediments, clams, fish, lobster, dulse, crabs, scallops and periwinkles. Background radiation is measured by thermoluminescence dosimetry.

Involving the expert in the delivery of environmental information from the web

International Nuclear Information System (INIS)

Wanner, Leo

2013-01-01

Automatic provision of accurate user need- and profile-tailored environmental information is of increasing demand. However, it is a challenging task with many facets. Among them is the difficulty to compile and cast into a formal representation all the expert knowledge needed to accurately and exhaustively acquire, assess and process the data in order to be able to reliably judge their relevance to the user and to produce an adequate summary and recommendations. Studies in Human-Computer Interaction show that both the satisfaction of the users with an application and the objective performance of a service increases if the users (in particular, experts) are assigned an active role in the system. Based on this insight, we propose a largely interactive environmental information acquisition and generation framework, which has been realized in the FP7 project ''Personalized Environmental Service Configuration and Delivery Orchestration'' (PESCaDO). The PESCaDO service involves the experts in four central tasks: (i) determination of criteria for the search of environmental nodes in the web; (ii) assessment of the relevance of the identified nodes; (iii) assessment of the quality of the data provided by the nodes, and (iv) selection of the content to be communicated to the user. Quantitative evaluations and user trials show that the performance of the system is good and the satisfaction with the service is high. (orig.)

Training for effective environmental protection in the nuclear industry

International Nuclear Information System (INIS)

Parkinson, D.; Brake, J.; Hickman, C.; Tamm, J.

2007-01-01

This paper examines the role of environmental training in the delivery of effective environmental protection programs for construction projects in the nuclear industry. The paper uses a case study approach, based on Point Lepreau Generating Station's Refurbishment Project, to demonstrate how the underpinning principles of 'training, awareness and competence' can be delivered within a structured environmental management framework, to achieve sustained excellence in environmental management and performance. Key issues addressed by the paper include the early identification of different target audiences, making effective use of communication themes, and the importance of reinforcement and follow-up in support of training goals. (author)

76 FR 59423 - Drakes Bay Oyster Company Special-Use Permit, Draft Environmental Impact Statement, Point Reyes...

Science.gov (United States)

2011-09-26

... commercial production, harvesting, processing, and sale of shellfish at Point Reyes National Seashore. The... Bay Oyster Company Special-Use Permit, Draft Environmental Impact Statement, Point Reyes National... Drakes Bay Oyster Company Special-use permit in Drakes Estero, Point Reyes National Seashore, California...

View Points of an Ecologist on Practical Environmental Ethic: Socioecology, Common-Pool Resources and Conservation.

Science.gov (United States)

Castilla, Juan Carlos

2016-01-01

The paper centers on environmental practical ethic point of views according to a professional ecologist. Ecology and the science of Socio-ecology are defined. The framework of the Millennium Ecosystem Assessment initiative (MA 2003), including the use of ecosystems as the environmental unit of analysis, ecosystem services and human well-being as the center for assessment are discussed. Common-pool resources (CPR) and the allegory of the tragedy of the commons are used to illustrate main scientific and ethical environmental approaches, and above all to highlight the case of climate change, considering ″air-atmosphere″ as a CPR. The need to adopt practical personal environmental ethical positions is highlighted. Furthermore, on climate change, a discussion on the need to develop environmental and socio-ecological polycentric approaches: top-down and bottom-up, is included. An updated discussion on the concept of conservation, including main scientific and ethic points of view, is presented. Pope Francis's Encyclical, Laudato Si', is used to highlight environmental, socio-ecological and ethical aspects behind the comprehensive concept of Integral Ecology. The paper ends with a short synthesis on Earth modern unseen and astonishing environmental and socio-ecological rates of changes, and identifying the main barriers for personal environmental engagement. A call is done regarding the urgent need for socio-environmental ethic personal engagement and collective actions.

Environmental radiation monitoring data for Point Lepreau Generating Station, 1990. Annual publication

Energy Technology Data Exchange (ETDEWEB)

Sutherland, J K

1991-01-01

Annual report presenting a compilation of the 1990 environmental radiation monitoring program data from samples collected around the Point Lepreau Nuclear Generating Station (PLNGS) and at reference stations remote from PLNGS. About 1,500 analyses were made on 1,100 samples to monitor environmental radiation, including air particulates, airborne water vapour, carbon dioxide in air, sea water, well water, milk, beach sediments, clams, fish, lobster, dulse, crabs, scallops, periwinkles, sea plants and lichen. Background radiation is measured by thermoluminescence dosimetry. Radon is not assessed.

Environmental protection standards - from the point of view of systems analysis

Energy Technology Data Exchange (ETDEWEB)

Becker, K

1978-11-01

A project of the International Institute of Applied Systems Analysis (IIASA) in Laxenburg castle near Vienna is reviewed where standards for environmental protection are interpreted from the point of view of systems analysis. Some examples are given to show how results are influenced not only by technical and economic factors but also by psychological and political factors.

Environmental protection standards - from the point of view of systems analysis

International Nuclear Information System (INIS)

Becker, K.

1978-01-01

A project of the International Institute of Applied Systems Analysis (IIASA) in Laxenburg castle near Vienna is reviewed where standards for environmental protection are interpreted from the point of view of systems analysis. Some examples are given to show how results are influenced not only by technical and economic factors but also by psychological and political factors. (orig.) [de

Electricity Delivery and its Environmental Impacts

Science.gov (United States)

Explains electricity delivery in the U.S. and its impacts on the environment. After a centralized power plant generates electricity, the electricity must be delivered to the end-user. Follow the path of electricity through transmission, substation, and dis

Environmental and Public Health Issues of Animal Food Products Delivery System in Imo State, Nigeria

Directory of Open Access Journals (Sweden)

Opara Maxwell Nwachukwu

2006-05-01

Full Text Available Information on livestock movement, animal food products processing facilities, meat inspection methods, official meat inspection records and distribution and marketing systems for processed products in Imo state, Nigeria needed for policy development interventions in the sector are not fully understood. The primary data generated with the aid of personal interviews, field observations and secondary data obtained from records accumulated by the department of veterinary services Imo state from 2001 to 2004 were used to investigate the environmental and public health issues of animal food products delivery system in state. Majority of trade animals supplied to the state originated from the northern states of the country and were brought in with trucks by road. Only two veterinary control posts served the whole state thus resulting in non-inspection and taxing of a large proportion of trade animals. Official record of trade animals supplied to the state from 2001 to 2004 ranged from 45000 – 144000 for cattle, 23000 – 96000 for goats and 11000 – 72000 for sheep per annum, with supplies increasing steadily across the years. Official slaughter points in the state were principally low-grade quality slaughter premises consisting of a thin concrete slab. Meat handling was very unhygienic with carcasses dressed beside refuse heaps of over 2 years standing. Carcasses were dragged on the ground and transported in taxi boots and open trucks. Meat inspection at these points was not thorough because of stiff resistance of butchers to carcass condemnation. Official meat inspection records for the state from 2001 to 2004 revealed that overall totals of 159,000 cattle, 101,000 goats and 67,000 sheep were slaughtered. This accounted for about 56, 57 and 57% shortfall of cattle, goat and sheep respectively supplied to the state and represents the volume of un-inspected animals during the study period. Fascioliasis and tuberculosis were the most common

Environmental tipping points significantly affect the cost−benefit assessment of climate policies

Science.gov (United States)

Cai, Yongyang; Judd, Kenneth L.; Lenton, Timothy M.; Lontzek, Thomas S.; Narita, Daiju

2015-01-01

Most current cost−benefit analyses of climate change policies suggest an optimal global climate policy that is significantly less stringent than the level required to meet the internationally agreed 2 °C target. This is partly because the sum of estimated economic damage of climate change across various sectors, such as energy use and changes in agricultural production, results in only a small economic loss or even a small economic gain in the gross world product under predicted levels of climate change. However, those cost−benefit analyses rarely take account of environmental tipping points leading to abrupt and irreversible impacts on market and nonmarket goods and services, including those provided by the climate and by ecosystems. Here we show that including environmental tipping point impacts in a stochastic dynamic integrated assessment model profoundly alters cost−benefit assessment of global climate policy. The risk of a tipping point, even if it only has nonmarket impacts, could substantially increase the present optimal carbon tax. For example, a risk of only 5% loss in nonmarket goods that occurs with a 5% annual probability at 4 °C increase of the global surface temperature causes an immediate two-thirds increase in optimal carbon tax. If the tipping point also has a 5% impact on market goods, the optimal carbon tax increases by more than a factor of 3. Hence existing cost−benefit assessments of global climate policy may be significantly underestimating the needs for controlling climate change. PMID:25825719

Environmental tipping points significantly affect the cost-benefit assessment of climate policies.

Science.gov (United States)

Cai, Yongyang; Judd, Kenneth L; Lenton, Timothy M; Lontzek, Thomas S; Narita, Daiju

2015-04-14

Most current cost-benefit analyses of climate change policies suggest an optimal global climate policy that is significantly less stringent than the level required to meet the internationally agreed 2 °C target. This is partly because the sum of estimated economic damage of climate change across various sectors, such as energy use and changes in agricultural production, results in only a small economic loss or even a small economic gain in the gross world product under predicted levels of climate change. However, those cost-benefit analyses rarely take account of environmental tipping points leading to abrupt and irreversible impacts on market and nonmarket goods and services, including those provided by the climate and by ecosystems. Here we show that including environmental tipping point impacts in a stochastic dynamic integrated assessment model profoundly alters cost-benefit assessment of global climate policy. The risk of a tipping point, even if it only has nonmarket impacts, could substantially increase the present optimal carbon tax. For example, a risk of only 5% loss in nonmarket goods that occurs with a 5% annual probability at 4 °C increase of the global surface temperature causes an immediate two-thirds increase in optimal carbon tax. If the tipping point also has a 5% impact on market goods, the optimal carbon tax increases by more than a factor of 3. Hence existing cost-benefit assessments of global climate policy may be significantly underestimating the needs for controlling climate change.

A planning and delivery study of a rotational IMRT technique with burst delivery

International Nuclear Information System (INIS)

Kainz, Kristofer; Chen, Guang-Pei; Chang, Yu-Wen; Prah, Douglas; Sharon Qi, X.; Shukla, Himanshu P.; Stahl, Johannes; Allen Li, X.

2011-01-01

Purpose: A novel rotational IMRT (rIMRT) technique using burst delivery (continuous gantry rotation with beam off during MLC repositioning) is investigated. The authors evaluate the plan quality and delivery efficiency and accuracy of this dynamic technique with a conventional flat 6 MV photon beam. Methods: Burst-delivery rIMRT was implemented in a planning system and delivered with a 160-MLC linac. Ten rIMRT plans were generated for five anonymized patient cases encompassing head and neck, brain, prostate, and prone breast. All plans were analyzed retrospectively and not used for treatment. Among the varied plan parameters were the number of optimization points, number of arcs, gantry speed, and gantry angle range (alpha) over which the beam is turned on at each optimization point. Combined rotational/step-and-shoot rIMRT plans were also created by superimposing multiple-segment static fields at several optimization points. The rIMRT trial plans were compared with each other and with plans generated using helical tomotherapy and VMAT. Burst-mode rotational IMRT plans were delivered and verified using a diode array, ionization chambers, thermoluminescent dosimeters, and film. Results: Burst-mode rIMRT can achieve plan quality comparable to helical tomotherapy, while the former may lead to slightly better OAR sparing for certain cases and the latter generally achieves slightly lower hot spots. Few instances were found in which increasing the number of optimization points above 36, or superimposing step-and-shoot IMRT segments, led to statistically significant improvements in OAR sparing. Using an additional rIMRT partial arc yielded substantial OAR dose improvements for the brain case. Measured doses from the rIMRT plan delivery were within 4% of the plan calculation in low dose gradient regions. Delivery time range was 228-375 s for single-arc rIMRT 200-cGy prescription with a 300 MU/min dose rate, comparable to tomotherapy and VMAT. Conclusions: Rotational IMRT

76 FR 12955 - CenterPoint Energy Gas Transmission Company, LLC; Notice of Intent To Prepare an Environmental...

Science.gov (United States)

2011-03-09

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP11-78-000] CenterPoint Energy Gas Transmission Company, LLC; Notice of Intent To Prepare an Environmental Assessment for the Proposed Line AM- 46 Replacement Project, Request for Comments on Environmental Issues, and Notice of Onsite Environmental Review The staff of the...

Urban Environmental Problems

International Nuclear Information System (INIS)

Situma, F.D.P.

1999-01-01

The rapid urbanization and resultant heavy concentration of population in urban centres have led to many urban areas failing to provide the necessary infrastructure and amenities as the demands placed on them have overwhelmed their financial and institutional capacities. In many urban areas, the capacity for resource mobilization and delivery of social services has either broken down completely or tethers on breaking point. Although in 1986 the GoK launched a new strategy for the balanced development of rural and urban areas aimed at avoiding excessive concentration of population in urban areas, the fruits of this strategy are yet to be realized. As a result, developments in urban areas have been unsustainable and environmentally unsound. The general quality of the environment has deteriorated so much so that urgent policy intervention is required. Appropriate environmental management measures and practices are needed to address the current trend of spiralling environmental problems in the context of the existing legal and institutional frameworks and makes some proposals for reform to address these problems in order to make urban areas environmentally

ACCESS TO LEP POINT 5, CESSY (FRANCE)

CERN Multimedia

1999-01-01

At the public environmental impact enquiry for the LHC project, the municipal authorities at Cessy suggested creating a new approach road to the civil engineering site (Point5) to ensure that materials deliveries by road are kept well away from housing along the Route de la Plaine.Following this recommendation, a track called the Chemin du Milieu has been upgraded into a road, and has been made available for the sole use of construction firms involved in building work at Point 5.The 'Dragados-Seli' consortium will be in charge of site surveillance for the new approach road.With effect from 29 March 1999, the present entrance will be closed to civil engineering firms and reserved for LEP installations maintenance services under the SL Division site managers, Mr. R. Spigato (tel. 160374) and P. Rey (tel. 160375).For obvious security reasons, those needing to use Point 5 are requested to keep the gate locked, even while they are on site, so as to prevent unauthorised persons from gaining access to the civil engi...

Observation of environmental radioactivity at definite time and definite point

International Nuclear Information System (INIS)

Inokoshi, Yukio; Fukuchi, Ryoichi; Irie, Takayuki; Hosoda, Nagako; Okano, Yasuhiro; Shindo, Koutaro

1990-01-01

The measurement of environmental radioactivity in Tokyo Metropolis was carried out. The objects of measurement were rainwater, atmospheric floating dusts, spatial dose and the activated sludge in sewage treatment plants. Rainwater, atmospheric floating dusts and spatial dose were analyzed mainly considering radioactive fallout, and activated sludge was analyzed mainly considering radioactive medical matters. For the analysis of nuclides, a Ge(Li) semiconductor detector was used, and spatial dose rate was measured with a DBM type dose rate meter. In activated sludge, the nuclides used for radioactive medicines were found, but in rainwater, atmospheric floating dusts and spatial dose, particular abnormality was not found. The objective of this investigation is to collect over long period at definite time and definite points the data on environmental radioactivity in Tokyo, thus to grasp the level of normal values, and in abnormal case, to clarify the cause and to evaluate the exposure dose. The instruments used, the method of measuring each object and the results are reported. (K.I.)

Indian Point Nuclear Generating Plant Unit No. 3 (Docket No. 50-286): Final environmental statement: Volume 2

International Nuclear Information System (INIS)

1975-02-01

This document contains nine appendices to Volume I, The Final Environmental Impact Statement for the Indian Point Nuclear Generating Plant Unit Number Three. Topics covered include thermal discharges to the Hudson River; supplemental information relating to biological models; radiation effects on aquatic biota; conditions, assumptions, and parameters used in calculating radioactive releases; meteorology for radiological dispersion calculations; life history information of important fish species in the Hudson River near Indian Point; additional information on cooling towers considered as alternatives; data and calculations for assessment of predicted electrical demand; and comments on draft environmental statement

Availability and Placement of Electronic Nicotine Delivery Systems at the Point-of-Sale.

Science.gov (United States)

Wagoner, Kimberly G; Song, Eunyoung; King, Jessica; Egan, Kathleen L; Debinski, Beata; Wolfson, Mark; Spangler, John; Sutfin, Erin L

2017-09-09

Electronic nicotine delivery systems (ENDS) are widely available and come in a variety of forms, including disposable cigalikes and refillable tank systems. However, little is known about their placement at the point-of-sale. We explored the placement of various ENDS types among tobacco retailers. Systematic assessments at the point-of-sale were completed by trained data collectors in 90 tobacco retailers, including grocery stores, convenience stores, and pharmacies in North Carolina, U.S. Availability and placement of various ENDS types including cigalikes, e-hookahs, tank systems and e-liquids was recorded. Almost all retailers (97.8%) sold cigalikes; 41.4% sold devices labeled as e-hookahs; 54.4% sold tank systems and 56.2% sold e-liquids. Fewer than half of stores placed ENDS exclusively behind the counter; significant differences in ENDS placement were found by store type. Grocery stores carried cigalikes, tank systems and e-liquids and placed them exclusively behind the counter. Pharmacies only sold cigalikes; most placed them exclusively behind the counter (91.7%) with cessation aids and other tobacco products. Convenience stores carried all ENDS types and placed them with other tobacco products (55.1%) and candy (17.4%). Only about one-third of convenience stores placed ENDS exclusively behind the counter. This exploratory study shows ENDS availability and placement at the point-of-sale varies by retailer type. Pharmacies placed cigalikes with cessation aids behind the counter suggesting their ability to aid in smoking cessation. Most convenience stores placed ENDS in self-service locations, making them easily accessible to youth. Findings highlight the need for ENDS regulation at the point-of-sale. Our study highlights the need for regulatory efforts aimed at ENDS placement at the point-of-sale. While pharmacies and grocery stores offered fewer ENDS types and typically placed them in clerk-assisted locations, all ENDS types were found at convenience stores

48 CFR 552.211-94 - Time of delivery.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Time of delivery. 552.211... of delivery. As prescribed at 511.404(d), insert the following clause: Time of Delivery (JAN 2010) An... points identified in the delivery order at its discretion in order to maintain the required stock levels...

Development of a point-of-use fortification technology for delivery of micronutrients in Honduras.

Science.gov (United States)

Andrade, Juan E; Rosales, Eliana; Lopez, Julio R; Carrillo, E Paola; Engeseth, Nicki J; Helferich, William G

2015-01-01

Micronutrient deficiencies continue to afflict children rural populations around the world. A micronutrient delivery vehicle (MDV) was developed as a point-of-use technology for fortification of meals for school-age children beneficiaries of the Healthy Schools Program (HSP) in Honduras. MDV combines micronutrient powder through a traditional dough-making process, using staple flours (wheat and nixtamalized corn), oil and water as ingredients. After mixing the ingredients and kneading, dough is extruded through a specially designed hand press into noodles. After drying (overnight, 23°C), noodles are broken into small pieces, mixed (1:100 w/w) with rice and cooked as customary. Dispersion studies with NaFeEDTA showed adequate distribution (90%) in white rice. Color changes in MDV due to addition of vitamin A and iron (NaFeEDTA) carried forward into cooked rice. In Honduras, children from two rural schools (N = 47, 6-12 years) were not able to differentiate (triangle test) between control and unfortified MDV mixed (1:100 w/w) with white rice. Children from four schools (N = 83, 7-12 years) accepted control and iron fortified rice (3 mg Fe per serving) based on color and flavor similarly. This is a feasible point-of-use fortification technology for improvement of meals provided by the HSP in Honduras. © 2014 Society of Chemical Industry.

30 CFR 208.8 - Transportation and delivery.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Transportation and delivery. 208.8 Section 208... MANAGEMENT SALE OF FEDERAL ROYALTY OIL General Provisions § 208.8 Transportation and delivery. (a) The lessee... delivery point at no additional cost to the purchaser or the Government. The purchaser must have physical...

The environmental zero-point problem in evolutionary reaction norm modeling.

Science.gov (United States)

Ergon, Rolf

2018-04-01

There is a potential problem in present quantitative genetics evolutionary modeling based on reaction norms. Such models are state-space models, where the multivariate breeder's equation in some form is used as the state equation that propagates the population state forward in time. These models use the implicit assumption of a constant reference environment, in many cases set to zero. This zero-point is often the environment a population is adapted to, that is, where the expected geometric mean fitness is maximized. Such environmental reference values follow from the state of the population system, and they are thus population properties. The environment the population is adapted to, is, in other words, an internal population property, independent of the external environment. It is only when the external environment coincides with the internal reference environment, or vice versa, that the population is adapted to the current environment. This is formally a result of state-space modeling theory, which is an important theoretical basis for evolutionary modeling. The potential zero-point problem is present in all types of reaction norm models, parametrized as well as function-valued, and the problem does not disappear when the reference environment is set to zero. As the environmental reference values are population characteristics, they ought to be modeled as such. Whether such characteristics are evolvable is an open question, but considering the complexity of evolutionary processes, such evolvability cannot be excluded without good arguments. As a straightforward solution, I propose to model the reference values as evolvable mean traits in their own right, in addition to other reaction norm traits. However, solutions based on an evolvable G matrix are also possible.

Performance Comparison of Widely-Used Maximum Power Point Tracker Algorithms under Real Environmental Conditions

Directory of Open Access Journals (Sweden)

DURUSU, A.

2014-08-01

Full Text Available Maximum power point trackers (MPPTs play an essential role in extracting power from photovoltaic (PV panels as they make the solar panels to operate at the maximum power point (MPP whatever the changes of environmental conditions are. For this reason, they take an important place in the increase of PV system efficiency. MPPTs are driven by MPPT algorithms and a number of MPPT algorithms are proposed in the literature. The comparison of the MPPT algorithms in literature are made by a sun simulator based test system under laboratory conditions for short durations. However, in this study, the performances of four most commonly used MPPT algorithms are compared under real environmental conditions for longer periods. A dual identical experimental setup is designed to make a comparison between two the considered MPPT algorithms as synchronized. As a result of this study, the ranking among these algorithms are presented and the results show that Incremental Conductance (IC algorithm gives the best performance.

A Dynamic Model of the Environmental Kuznets Curve. Turning Point and Public Policy

Energy Technology Data Exchange (ETDEWEB)

Egli, H.; Steger, T.M. [CER-ETH Center of Economic Research at ETH Zurich, ZUE F 10, CH-8092 Zurich (Switzerland)

2007-01-15

We set up a simple dynamic macroeconomic model with (1) polluting consumption and a preference for a clean environment, (2) increasing returns in abatement giving rise to an EKC and (3) sustained growth resulting from a linear final-output technology. There are two sorts of market failures caused by external effects associated with consumption and environmental effort. The model is employed to investigate the determinants of the turning point and the cost effectiveness of different public policies aimed at a reduction of the environmental burden. Moreover, the model offers a potential explanation of an N-shaped pollution-income relation. It is shown that the model is compatible with most empirical regularities on economic growth and the environment.

SMART POLYMERS: INNOVATIONS IN NOVEL DRUG DELIVERY

OpenAIRE

Apoorva Mahajan; Geeta Aggarwal

2011-01-01

Smart polymers are attracting the researchers for development of novel drug delivery systems. Importance of smart polymers is rising day by day as these polymers undergo large reversible, physical or chemical changes in response to small changes in the environmental conditions such as pH, temperature, dual- stimuli, light and phase transition. Smart polymers are representing promising means for targeted drug delivery, enhanced drug delivery, gene therapy, actuator stimuli and protein folders....

Development of a software of VMAT delivery using EPID

International Nuclear Information System (INIS)

Arumugam, Sankar; Xing, Aitang; Jameson, Michael; Holloway, Lois; Goozee, Gary

2011-01-01

Full text: Volumetric Modulated Arc Therapy (VMAT) is more complex than standard IMRT, requiring new methodology to evaluate delivery accuracy. Here, we present the development of methodology and a software tool to perform control point based verification of VMAT delivery using an EPID. Individual segment dose comparison allows the verification of VMAT deli very accuracy for individual control-points. An in-house software tool was developed to predict the individual segment dose as measured by EPID for Pinnacle (Philips) generated VMAT plans. The VMAT plans were delivered using an Elekta-synergy accelerator and the segment doses were measured using EPID. A normalised dose comparison of measured and predicted doses was performed using gamma analysis with 3% dose tolerance and 3 mm DTA. The sensitivity of the proposed methodology in detecting delivery errors was studied by delivering a standard intensity pattern with a preset dose error of 4 and 5% in two of its eight control-points. Four clinical plans were also tested using this methodology. The developed software accurately predicts the EPID dose by considering all possible leaf trajectories in VMAT delivery. The mean gamma value and percentage of pixels exceeding the gamma tolerance for a segment with and without delivery errors are shown in Table. From the tabulated values it is evident that the proposed methodology is sensitive in detecting delivery errors above 3% tolerance level. The clinical plans were successfully validated showing a maximum 2.5% of pixels exceeding gamma tolerance. Methodology and a software were successfully developed to perform control-point validation of VMAT delivery using an EPID. Set error in Delivery (%) Mean gamma value% of pixels exceeding Gamma tolerance 0 0.40 1.240.5417.050.6221.8.

Final Environmental Statement related to the operation of Nine Mile Point Nuclear Station, Unit No. 2 (Docket No. 50-410)

International Nuclear Information System (INIS)

1985-05-01

This Final Environmental Statement contains the assessment of the environmental impact associated with the operation of the Nine Mile Point Nuclear Station, Unit 2, pursuant to the National Environmental Policy Act of 1969 (NEPA) and Title 10 of the Code of Federal Regulations, Part 51, as amended, of the Nuclear Regulatory Commission regulations. This statement examines the environment, environmental consequences and mitigating actions, and environmental and economic benefits and costs

A Multi-Modality Mobility Concept for a Small Package Delivery UAV

Science.gov (United States)

Young, L. A.

2017-01-01

This paper will discuss a different approach to the typical notional small package delivery drone concept. Most delivery drone concepts employ a point-to-point aerial delivery CONOPS (Concept of Operations) from a warehouse directly to the front or back yards of a customers residence or a commercial office space. Instead, the proposed approach is somewhat analogous to current postal deliveries: a small aerial vehicle flies from a warehouse to designated neighborhood VTOL (Vertical Take-Off and Landing) landing spots where the aerial vehicle then converts to a "roadable" (ground-mobility) vehicle that then transits on sidewalks and/or bicycle paths till it arrives to the residence/office drop-off points. This concept and associated platform or vehicle will be referred in this paper as MICHAEL (Multimodal Intra-City Hauling and Aerial-Effected Logistics) concept. It is suggested that the MICHAEL concept potentially results in a more community friendly "delivery drone" approach.

Revisiting Ecosystem Services: Assessment and Valuation as Starting Points for Environmental Politics

Directory of Open Access Journals (Sweden)

Adam Jadhav

2017-09-01

Full Text Available The paradigm of ecosystem services (ES and the methods of monetary valuation have become boundary objects, spanning disciplines and earning particular purchase in policy circles. However, the notion of ES and ES valuation have also been subjected to multiple critiques, ranging from their varying precision to the potential for neoliberalization of nature. This paper does not attempt to refute such critiques but rather revisits the potentials of the ES paradigm and the specific method of benefit transfer valuation for their utility as a form of environmental politics and sustainability practice. We find they have particular relevance in contexts where “data” are not readily available or are not legible to policy makers as well as where the imperative of “development” remains ideological. We argue for ES assessment and, specifically, rapid ES valuation as a first-pass tactic to inform evaluation of potentially environmentally degrading projects or environmental management. We demonstrate this using a simple benefit transfer analysis to offer an initial evaluation of (wet landscape ES in a lightly touched estuary in Karnataka, India, where a state-backed proposal to develop an industrial shipping port is gathering steam. While we recognize and do not categorically reject critiques of the ES paradigm, we nonetheless argue for valuation as a starting point for politics that highlight and make visible ES benefits and users implicated by “development” and other kinds of environmental change.

Point-of-care technology: integration for improved delivery of care.

Science.gov (United States)

Gregory, Debbie; Buckner, Martha

2014-01-01

The growing complexity of technology, equipment, and devices involved in patient care delivery can be staggering and overwhelming. Technology is intended to be a tool to help clinicians, but it can also be a frustrating hindrance if not thoughtfully planned and strategically aligned. Critical care nurses are key partners in the collaborations needed to improve safety and quality through health information technology (IT). Nurses must advocate for systems that are interoperable and adapted to the context of care experiences. The involvement and collaboration between clinicians, information technology specialists, biomedical engineers, and vendors has never been more relevant and applicable. Working together strategically with a shared vision can effectively provide a seamless clinical workflow, maximize technology investments, and ultimately improve patient care delivery and outcomes. Developing a strategic integrated clinical and IT roadmap is a critical component of today's health care environment. How can technology strategy be aligned from the executive suite to the bedside caregiver? What is the model for using clinical workflows to drive technology adoption? How can the voice of the critical care nurse strengthen this process? How can success be assured from the initial assessment and selection of technology to a sustainable support model? What is the vendor's role as a strategic partner and "co-caregiver"?

Model Projections of Future Fluvial Sediment Delivery to Major Deltas Under Environmental Change

Science.gov (United States)

Darby, S. E.; Dunn, F.; Nicholls, R. J.; Cohen, S.; Zarfl, C.

2017-12-01

Deltas are important hot spots for climate change impacts on which over half a billion people live worldwide. Most of the world's deltas are sinking as a result of natural and anthropogenic subsidence and due to eustatic sea level rise. The ability to predict rates of delta aggradation is therefore critical to assessments of the extent to which sedimentation can potentially offset sea level rise, but our ability to make such predictions is severely hindered by a lack of insight into future trends of the fluvial sediment load supplied to their deltas by feeder watersheds. To address this gap we investigate fluvial sediment fluxes under future environmental change for a selection (47) of the world's major river deltas. Specifically, we employed the numerical model WBMsed to project future variations in mean annual fluvial sediment loads under a range of environmental change scenarios that account for changes in climate, socio-economics and dam construction. Our projections indicate a clear decrease (by 34 to 41% on average, depending on the specific scenario) in future fluvial sediment supply to most of the 47 deltas. These reductions in sediment delivery are driven primarily by anthropogenic disturbances, with reservoir construction being the most influential factor globally. Our results indicate the importance of developing new management strategies for reservoir construction and operation.

Hamburgian weapon delivery technology: a quantitative comparative approach

DEFF Research Database (Denmark)

Riede, Felix

2010-01-01

cran). Numerous studies have addressed the question of whether these points tipped arrows fired from bows, darts launched with the help of spear-throwers, or some other projectile delivery weapon. This paper approaches the question of Hamburgian weapon delivery technology from a quantitative...

Ecosystem approach to fisheries: Exploring environmental and trophic effects on Maximum Sustainable Yield (MSY reference point estimates.

Directory of Open Access Journals (Sweden)

Rajeev Kumar

Full Text Available We present a comprehensive analysis of estimation of fisheries Maximum Sustainable Yield (MSY reference points using an ecosystem model built for Mille Lacs Lake, the second largest lake within Minnesota, USA. Data from single-species modelling output, extensive annual sampling for species abundances, annual catch-survey, stomach-content analysis for predatory-prey interactions, and expert opinions were brought together within the framework of an Ecopath with Ecosim (EwE ecosystem model. An increase in the lake water temperature was observed in the last few decades; therefore, we also incorporated a temperature forcing function in the EwE model to capture the influences of changing temperature on the species composition and food web. The EwE model was fitted to abundance and catch time-series for the period 1985 to 2006. Using the ecosystem model, we estimated reference points for most of the fished species in the lake at single-species as well as ecosystem levels with and without considering the influence of temperature change; therefore, our analysis investigated the trophic and temperature effects on the reference points. The paper concludes that reference points such as MSY are not stationary, but change when (1 environmental conditions alter species productivity and (2 fishing on predators alters the compensatory response of their prey. Thus, it is necessary for the management to re-estimate or re-evaluate the reference points when changes in environmental conditions and/or major shifts in species abundance or community structure are observed.

Efficiency and economics of hydrogen delivery

International Nuclear Information System (INIS)

Liu, Y.; Bharadwaj, R.; Balan, C.; Garces, L.; Smith, D.

2003-01-01

The viability and penetration of fuel cell based electricity production will be mainly determined by the efficient, cost effective production and delivery of hydrogen. This study focuses on the transportation efficiency and cost of hydrogen delivery for both centrally produced hydrogen as well as electricity scenarios. The efficiency and economics of energy delivery depend on the quantity of energy to be transported and transportation distance. Energy delivery models were developed for Hydrogen delivery as compressed gas or cryogenic liquid using truck or pipeline. For comparison, models were also developed for high voltage AC electricity transmission. Major parameters that influence the performance of the energy transmission systems under normal operating conditions were modeled. The models use energy transported and delivery distance as independent variables. The results were validated against similar reports, government surveys and other publications. Energy delivery efficiency and costs were used to compare and evaluate the different delivery options. Effect of uncertainty and sensitivity of parameters on modeling results were also studied. The systems were compared on an equivalent basis. The analysis also identifies the trade-offs for electricity transmission and electrolysis application at the point of use for Hydrogen delivery. These results provide a consistent framework for evaluation of delivery options on energy efficiency basis. (author)

Environmental effects on recruitment and implications for biological reference points of Eastern Baltic cod (Gadus morhua)

DEFF Research Database (Denmark)

Köster, Fritz; Vinther, Morten; MacKenzie, Brian

2009-01-01

The decline of the Eastern Baltic cod (Gadus morhua) stock from highest to lowest stock levels on record throughout the 1980s and early 1990s was caused by a combination of recruitment failure and increasing fishing pressure at declining stock sizes. The processes driving the reproductive success...... mortality or the limit biomass reference point is indicated. However, an accepted methodology to determine these reference points in situations of changing stock productivity or system carrying capacity does not exist. Environmental conditions affecting recruitment matter not only for the determination...

Necessity of exploitation of nuclear energy in China from the environmental protection point of view

Energy Technology Data Exchange (ETDEWEB)

Ziqiang, Pan; Xiwen, Jiang; Shaoyi, Song; Shutian, Liu; Guang, Bai

1984-09-01

The article proves the necessity of development of nuclear energy in China from the enviromental protection point of view. The development of nuclear energy would decrease environmental contamination due to energy power production. The prediction of collective dose equivalent commitment from the nuclear power plant in year 2000 would only amount to 0.013% of annual collective dose equivalent from natural radiation sources.

Bioresponsive matrices in drug delivery

Directory of Open Access Journals (Sweden)

Ye George JC

2010-11-01

Full Text Available Abstract For years, the field of drug delivery has focused on (1 controlling the release of a therapeutic and (2 targeting the therapeutic to a specific cell type. These research endeavors have concentrated mainly on the development of new degradable polymers and molecule-labeled drug delivery vehicles. Recent interest in biomaterials that respond to their environment have opened new methods to trigger the release of drugs and localize the therapeutic within a particular site. These novel biomaterials, usually termed "smart" or "intelligent", are able to deliver a therapeutic agent based on either environmental cues or a remote stimulus. Stimuli-responsive materials could potentially elicit a therapeutically effective dose without adverse side effects. Polymers responding to different stimuli, such as pH, light, temperature, ultrasound, magnetism, or biomolecules have been investigated as potential drug delivery vehicles. This review describes the most recent advances in "smart" drug delivery systems that respond to one or multiple stimuli.

Environmental Assessment of Packaging: The Consumer Point of View

Science.gov (United States)

Van Dam YK

1996-09-01

When marketing environmentally responsible packaged products, the producer is confronted with consumer beliefs concerning the environmental friendliness of packaging materials. When making environmentally conscious packaging decisions, these consumer beliefs should be taken into account alongside the technical guidelines. Dutch consumer perceptions of the environmental friendliness of packaged products are reported and compared with the results of a life-cycle analysis assessment. It is shown that consumers judge environmental friendliness mainly from material and returnability. Furthermore, the consumer perception of the environmental friendliness of packaging material is based on the postconsumption waste, whereas the environmental effects of production are ignored. From the consumer beliefs concerning environmental friendliness implications are deduced for packaging policy and for environmental policy.KEY WORDS: Consumer behavior; Environment; Food; Packaging; Perception; Waste

Municipal service delivery SET for success

CSIR Research Space (South Africa)

Naidoo, S

2015-10-01

Full Text Available The application of scientific, engineering and technological solutions by the CSIR to support local government environmental management and service delivery has the potential for significant impact. A case study illustrates the application...

Ground Control Point - Wireless System Network for UAV-based environmental monitoring applications

Science.gov (United States)

Mejia-Aguilar, Abraham

2016-04-01

In recent years, Unmanned Aerial Vehicles (UAV) have seen widespread civil applications including usage for survey and monitoring services in areas such as agriculture, construction and civil engineering, private surveillance and reconnaissance services and cultural heritage management. Most aerial monitoring services require the integration of information acquired during the flight (such as imagery) with ground-based information (such as GPS information or others) for improved ground truth validation. For example, to obtain an accurate 3D and Digital Elevation Model based on aerial imagery, it is necessary to include ground-based information of coordinate points, which are normally acquired with surveying methods based on Global Position Systems (GPS). However, GPS surveys are very time consuming and especially for longer time series of monitoring data repeated GPS surveys are necessary. In order to improve speed of data collection and integration, this work presents an autonomous system based on Waspmote technologies build on single nodes interlinked in a Wireless Sensor Network (WSN) star-topology for ground based information collection and later integration with surveying data obtained by UAV. Nodes are designed to be visible from the air, to resist extreme weather conditions with low-power consumption. Besides, nodes are equipped with GPS as well as Inertial Measurement Unit (IMU), accelerometer, temperature and soil moisture sensors and thus provide significant advantages in a broad range of applications for environmental monitoring. For our purpose, the WSN transmits the environmental data with 3G/GPRS to a database on a regular time basis. This project provides a detailed case study and implementation of a Ground Control Point System Network for UAV-based vegetation monitoring of dry mountain grassland in the Matsch valley, Italy.

Amendment of the assured delivery provisions of BPA's Long-Term Intertie Access Policy and increased assured delivery: Access for non-scheduling utilities. Record of decision

International Nuclear Information System (INIS)

1994-06-01

Bonneville Power Administration's BPA's preferred alternative for providing non-Federal Pacific Northwest-Pacific Southwest (PNW-PSW) Intertie access is to adopt the Capacity Ownership alternative combined with the Increased Assured Delivery--Access for Non-Scheduling Utilities alternative. BPA's decision to offer Capacity Ownership was documented in a March 1994 Non-Federal Capacity Ownership Record of Decision (ROD). This ROD documents BPA's decision to facilitate PNW-PSW Intertie access by proceeding with (1) bidirectional Increased Assured Delivery--Access for Non Scheduling Utilities; and (2) amending the Assured Delivery provisions of BPA's Long-Term Intertie Access Policy (LTIAP). Given that the various non-Federal PNW-PSW Intertie access alternatives in the NFP EIS all allowed for different types of contracts, little environmental impact difference among the alternatives was found. Rather, environmental impact was found to be associated with whether exchange contracts or firm power sales contracts would predominate. Such impacts and related environmental analysis are discussed further in section 3.0 of this ROD

Dosimetric verification of RapidArc treatment delivery

DEFF Research Database (Denmark)

Korreman, Stine; Medin, Joakim; Kjaer-Kristoffersen, Flemming

2009-01-01

. METHODS AND MATERIALS: Nine treatment plans were generated in the Eclipse version 8.5 including the RapidArc optimizer for H&N and prostate cases. The plans were delivered to the Scandidos Delta4 cylindrical diode array phantom. First, the measured dose distributions were compared with the calculated......: Overall, good agreement was observed between measured and calculated doses in most cases with gamma values above 1 in >95% of measured points. The reproducibility of delivery was also very high. Gamma analysis between two consecutive runs of the same delivery plan generally showed gamma values above 1......: The delivery of RapidArc beam delivery has been verified to correspond well with calculated dose distributions for a number of different cases. The delivery was very reproducible, and was carried out with high stability of the accelerator performance....

Polymer nanogels: a versatile nanoscopic drug delivery platform

Science.gov (United States)

Chacko, Reuben T.; Ventura, Judy; Zhuang, Jiaming; Thayumanavan, S.

2012-01-01

In this review we put the spotlight on crosslinked polymer nanogels, a promising platform that has the characteristics of an “ideal” drug delivery vehicle. Some of the key aspects of drug delivery vehicle design like stability, response to biologically relevant stimuli, passive targeting, active targeting, toxicity and ease of synthesis are discussed. We discuss several delivery systems in this light and highlight some examples of systems, which satisfy some or all of these design requirements. In particular, we point to the advantages that crosslinked polymeric systems bring to drug delivery. We review some of the synthetic methods of nanogel synthesis and conclude with the diverse applications in drug delivery where nanogels have been fruitfully employed. PMID:22342438

Streamlining project delivery through risk analysis.

Science.gov (United States)

2015-08-01

Project delivery is a significant area of concern and is subject to several risks throughout Plan Development : Process (PDP). These risks are attributed to major areas of project development, such as environmental : analysis, right-of-way (ROW) acqu...

The Delivery of Health Promotion and Environmental Health Services; Public Health or Primary Care Settings?

Directory of Open Access Journals (Sweden)

Lene Bjørn Jensen

2018-05-01

Full Text Available The WHO Regional Office for Europe developed a set of public health functions resulting in the ten Essential Public Health Operations (EPHO. Public health or primary care settings seem to be favorable to embrace all actions included into EPHOs. The presented paper aims to guide readers on how to assign individual health promotion and environmental health services to public health or primary care settings. Survey tools were developed based on EPHO 2, 3 and 4; there were six key informant surveys out of 18 contacted completed via e-mails by informants working in Denmark on health promotion and five face-to-face interviews were conducted in Australia (Melbourne and Victoria state with experts from environmental health, public health and a physician. Based on interviews, we developed a set of indicators to support the assignment process. Population or individual focus, a system approach or one-to-one approach, dealing with hazards or dealing with effects, being proactive or reactive were identified as main element of the decision tool. Assignment of public health services to one of two settings proved to be possible in some cases, whereas in many there is no clear distinction between the two settings. National context might be the one which guides delivery of public health services.

The Delivery of Health Promotion and Environmental Health Services; Public Health or Primary Care Settings?

Science.gov (United States)

Bjørn Jensen, Lene; Lukic, Irena; Gulis, Gabriel

2018-05-07

The WHO Regional Office for Europe developed a set of public health functions resulting in the ten Essential Public Health Operations (EPHO). Public health or primary care settings seem to be favorable to embrace all actions included into EPHOs. The presented paper aims to guide readers on how to assign individual health promotion and environmental health services to public health or primary care settings. Survey tools were developed based on EPHO 2, 3 and 4; there were six key informant surveys out of 18 contacted completed via e-mails by informants working in Denmark on health promotion and five face-to-face interviews were conducted in Australia (Melbourne and Victoria state) with experts from environmental health, public health and a physician. Based on interviews, we developed a set of indicators to support the assignment process. Population or individual focus, a system approach or one-to-one approach, dealing with hazards or dealing with effects, being proactive or reactive were identified as main element of the decision tool. Assignment of public health services to one of two settings proved to be possible in some cases, whereas in many there is no clear distinction between the two settings. National context might be the one which guides delivery of public health services.

Feasibility of using microbiology diagnostic tests of moderate or high complexity at the point - of - care in a delivery suite.

Science.gov (United States)

Gray, J W; Milner, P J; Edwards, E H; Daniels, J P; Khan, K S

2012-07-01

Point-of-care testing (POCT) is one of the fastest growing sectors of laboratory diagnostics. Most tests in routine use are haematology or biochemistry tests that are of low complexity. Microbiology POCT has been constrained by a lack of tests that are both accurate and of low complexity. We describe our experience of the practical issues around using more complex POCT for detection of Group B streptococci (GBS) in swabs from labouring women. We evaluated two tests for their feasibility in POCT: an optical immune assay (Biostar OIA Strep B, Inverness Medical, Princetown, NJ) and a PCR (IDI-Strep B, Cepheid, Sunnyvale, CA), which have been categorised as being of moderate and high complexity, respectively. A total of 12 unqualified midwifery assistants (MA) were trained to undertake testing on the delivery suite. A systematic approach to the introduction and management of POC testing was used. Modelling showed that the probability of test results being available within a clinically useful timescale was high. However, in the clinical setting, we found it impossible to maintain reliable availability of trained testers. Implementation of more complex POC testing is technically feasible, but it is expensive, and may be difficult to achieve in a busy delivery suite.

78 FR 4164 - Draft Environmental Impact Statement for the Proposed Point Molate Resort and Casino for the...

Science.gov (United States)

2013-01-18

... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Draft Environmental Impact Statement for the Proposed Point Molate Resort and Casino for the Guidiville Band of the Pomo Indians, Contra Costa County... Impact Statement (EIS) for the BIA Federal action of approving the fee-to- trust transfer and casino...

Does low to moderate environmental exposure to noise and air pollution influence preterm delivery in medium-sized cities?

Science.gov (United States)

Barba-Vasseur, Marie; Bernard, Nadine; Pujol, Sophie; Sagot, Paul; Riethmuller, Didier; Thiriez, Gérard; Houot, Hélène; Defrance, Jérôme; Mariet, Anne-Sophie; Luu, Vinh-Phuc; Barbier, Alice; Benzenine, Eric; Quantin, Catherine; Mauny, Frédéric

2017-12-01

Preterm birth (PB) is an important predictor of childhood morbidity and educational performance. Beyond the known risk factors, environmental factors, such as air pollution and noise, have been implicated in PB. In urban areas, these pollutants coexist. Very few studies have examined the effects of multi-exposure on the pregnancy duration. The objective of this study was to analyse the relationship between PB and environmental chronic multi-exposure to noise and air pollution in medium-sized cities. A case-control study was conducted among women living in the city of Besançon (121 671 inhabitants) or in the urban unit of Dijon (243 936 inhabitants) and who delivered in a university hospital between 2005 and 2009. Only singleton pregnancies without associated pathologies were considered. Four controls were matched to each case in terms of the mother's age and delivery location. Residential noise and nitrogen dioxide (NO2) exposures were calculated at the mother's address. Conditional logistic regression models were applied, and sensitivity analyses were performed. This study included 302 cases and 1204 controls. The correlation between noise and NO2 indices ranged from 0.41 to 0.59. No significant differences were found in pollutant exposure levels between cases and controls. The adjusted odds ratios ranged between 0.96 and 1.08. Sensitivity analysis conducted using different temporal and spatial exposure windows demonstrated the same results. The results are in favour of a lack of connection between preterm delivery and multi-exposure to noise and air pollution in medium-sized cities for pregnant women without underlying disease. © The Author 2017; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association

Analysis of the environmental behavior of farmers for non-point source pollution control and management in a water source protection area in China.

Science.gov (United States)

Wang, Yandong; Yang, Jun; Liang, Jiping; Qiang, Yanfang; Fang, Shanqi; Gao, Minxue; Fan, Xiaoyu; Yang, Gaihe; Zhang, Baowen; Feng, Yongzhong

2018-08-15

The environmental behavior of farmers plays an important role in exploring the causes of non-point source pollution and taking scientific control and management measures. Based on the theory of planned behavior (TPB), the present study investigated the environmental behavior of farmers in the Water Source Area of the Middle Route of the South-to-North Water Diversion Project in China. Results showed that TPB could explain farmers' environmental behavior (SMC=0.26) and intention (SMC=0.36) well. Furthermore, the farmers' attitude towards behavior (AB), subjective norm (SN), and perceived behavioral control (PBC) positively and significantly influenced their environmental intention; their environmental intention further impacted their behavior. SN was proved to be the main key factor indirectly influencing the farmers' environmental behavior, while PBC had no significant and direct effect. Moreover, environmental knowledge following as a moderator, gender and age was used as control variables to conduct the environmental knowledge on TPB construct moderated mediation analysis. It demonstrated that gender had a significant controlling effect on environmental behavior; that is, males engage in more environmentally friendly behaviors. However, age showed a significant negative controlling effect on pro-environmental intention and an opposite effect on pro-environmental behavior. In addition, environmental knowledge could negatively moderate the relationship between PBC and environmental intention. PBC had a greater impact on the environmental intention of farmers with poor environmental knowledge, compared to those with plenty environmental knowledge. Altogether, the present study could provide a theoretical basis for non-point source pollution control and management. Copyright © 2018 Elsevier B.V. All rights reserved.

Buccal and sublingual vaccine delivery.

Science.gov (United States)

Kraan, Heleen; Vrieling, Hilde; Czerkinsky, Cecil; Jiskoot, Wim; Kersten, Gideon; Amorij, Jean-Pierre

2014-09-28

Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination. An important characteristic of mucosal vaccination is its ability to elicit local immune responses, which act against infection at the site of pathogen entry. However, mucosal surfaces are endowed with potent and sophisticated tolerance mechanisms to prevent the immune system from overreacting to the many environmental antigens. Hence, mucosal vaccination may suppress the immune system instead of induce a protective immune response. Therefore, mucosal adjuvants and/or special antigen delivery systems as well as appropriate dosage forms are required in order to develop potent mucosal vaccines. Whereas oral, nasal and pulmonary vaccine delivery strategies have been described extensively, the sublingual and buccal routes have received considerably less attention. In this review, the characteristics of and approaches for sublingual and buccal vaccine delivery are described and compared with other mucosal vaccine delivery sites. We discuss recent progress and highlight promising developments in the search for vaccine formulations, including adjuvants and suitable dosage forms, which are likely critical for designing a successful sublingual or buccal vaccine. Finally, we outline the challenges, hurdles to overcome and formulation issues relevant for sublingual or buccal vaccine delivery. Copyright © 2014. Published by Elsevier B.V.

Protein-Based Drug-Delivery Materials

Directory of Open Access Journals (Sweden)

Dave Jao

2017-05-01

Full Text Available There is a pressing need for long-term, controlled drug release for sustained treatment of chronic or persistent medical conditions and diseases. Guided drug delivery is difficult because therapeutic compounds need to survive numerous transport barriers and binding targets throughout the body. Nanoscale protein-based polymers are increasingly used for drug and vaccine delivery to cross these biological barriers and through blood circulation to their molecular site of action. Protein-based polymers compared to synthetic polymers have the advantages of good biocompatibility, biodegradability, environmental sustainability, cost effectiveness and availability. This review addresses the sources of protein-based polymers, compares the similarity and differences, and highlights characteristic properties and functionality of these protein materials for sustained and controlled drug release. Targeted drug delivery using highly functional multicomponent protein composites to guide active drugs to the site of interest will also be discussed. A systematical elucidation of drug-delivery efficiency in the case of molecular weight, particle size, shape, morphology, and porosity of materials will then be demonstrated to achieve increased drug absorption. Finally, several important biomedical applications of protein-based materials with drug-delivery function—including bone healing, antibiotic release, wound healing, and corneal regeneration, as well as diabetes, neuroinflammation and cancer treatments—are summarized at the end of this review.

The necessity of exploitation of nuclear energy in China from the environmental protection point of view

International Nuclear Information System (INIS)

Pan Ziqiang; Jiang Xiwen; Song Shaoyi; Liu Shutian; Bai Guang

1984-01-01

The article proves the necessity of development of nuclear energy in China from the enviromental protection point of view. The development of nuclear energy would be decrease environmental contamination due to energy power production. The prediction of collective dose equivalent commitment from the nuclear power plant in year 2000 would only amount to 0.013% of annual collective dose equivalent from natural radiation sources

Wolf Point Substation, Roosevelt County, Montana

International Nuclear Information System (INIS)

1991-05-01

The Western Area Power Administration (Western), an agency of the United States Department of Energy, is proposing to construct the 115-kV Wolf Point Substation near Wolf Point in Roosevelt County, Montana (Figure 1). As part of the construction project, Western's existing Wolf Point Substation would be taken out of service. The existing 115-kV Wolf Point Substation is located approximately 3 miles west of Wolf Point, Montana (Figure 2). The substation was constructed in 1949. The existing Wolf Point Substation serves as a ''Switching Station'' for the 115-kV transmission in the region. The need for substation improvements is based on operational and reliability issues. For this environmental assessment (EA), the environmental review of the proposed project took into account the removal of the old Wolf Point Substation, rerouting of the five Western lines and four lines from the Cooperatives and Montana-Dakota Utilities Company, and the new road into the proposed substation. Reference to the new proposed Wolf Point Substation in the EA includes these facilities as well as the old substation site. The environmental review looked at the impacts to all resource areas in the Wolf Point area. 7 refs., 6 figs

Applying environmental product design to biomedical products research.

Science.gov (United States)

Messelbeck, J; Sutherland, L

2000-12-01

The principal themes for the Biomedical Research and the Environment Conference Committee on Environmental Economics in Biomedical Research include the following: healthcare delivery companies and biomedical research organizations, both nonprofit and for-profit, need to improve their environmental performance; suppliers of healthcare products will be called upon to support this need; and improving the environmental profile of healthcare products begins in research and development (R&D). The committee report begins with requirements from regulatory authorities (e.g., U.S. Environmental Protection Agency [EPA], the U.S. Food and Drug Administration), and the healthcare delivery sector). The 1998 American Hospital Association and EPA Memorandum of Understanding to reduce solid waste and mercury from healthcare facilities is emblematic of these requirements. The dominant message from the requirements discussion is to ensure that R&D organizations do not ignore customer, environmental, and regulatory requirements in the early stages of product development. Several representatives from healthcare products manufacturers presented their companies' approaches to meeting these requirements. They reported on efforts to ensure that their R&D processes are sensitive to the environmental consequences from manufacturing, distributing, using, and disposing of healthcare products. These reports describe representatives' awareness of requirements and the unique approaches their R&D organizations have taken to meet these requirements. All representatives reported that their R&D organizations have embraced environmental product design because it avoids the potential of returning products to R&D to improve the environmental profile. Additionally, several reports detailed cost savings, sustainability benefits, and improvements in environmental manufacturing or redesign, and increased customer satisfaction. Many companies in healthcare delivery are working to improve environmental

Sustained subconjunctival protein delivery using a thermosetting gel delivery system.

Science.gov (United States)

Rieke, Erin R; Amaral, Juan; Becerra, S Patricia; Lutz, Robert J

2010-02-01

An effective treatment modality for posterior eye diseases would provide prolonged delivery of therapeutic agents, including macromolecules, to eye tissues using a safe and minimally invasive method. The goal of this study was to assess the ability of a thermosetting gel to deliver a fluorescently labeled protein, Alexa 647 ovalbumin, to the choroid and retina of rats following a single subconjunctival injection of the gel. Additional experiments were performed to compare in vitro to in vivo ovalbumin release rates from the gel. The ovalbumin content of the eye tissues was monitored by spectrophotometric assays of tissue extracts of Alexa 647 ovalbumin from dissected sclera, choroid, and retina at time points ranging from 2 h to 14 days. At the same time points, fluorescence microscopy images of tissue samples were also obtained. Measurement of intact ovalbumin was verified by LDS-PAGE analysis of the tissue extract solutions. In vitro release of Alexa 488 ovalbumin into 37 degrees C PBS solutions from ovalbumin-loaded gel pellets was also monitored over time by spectrophotometric assay. In vivo ovalbumin release rates were determined by measurement of residual ovalbumin extracted from gel pellets removed from rat eyes at various time intervals. Our results indicate that ovalbumin concentrations can be maintained at measurable levels in the sclera, choroid, and retina of rats for up to 14 days using the thermosetting gel delivery system. The concentration of ovalbumin exhibited a gradient that decreased from sclera to choroid and to retina. The in vitro release rate profiles were similar to the in vivo release profiles. Our findings suggest that the thermosetting gel system may be a feasible method for safe and convenient sustained delivery of proteins to choroidal and retinal tissue in the posterior segments of the eye.

Implications for the inter-organizational design of environmental care when changing environmental control points

NARCIS (Netherlands)

Hagelaar, J.L.F.; Seuring, S.

2006-01-01

In this paper we try to bridge the gap between two lines of thought within the environmental care literature. We differentiate between two major clusters in this literature; (1) environmental management and (2) strategic approach to environmental care. Although both approaches focus on the same

Impact of nutrition environmental interventions on point-of-purchase behavior in adults: a review.

Science.gov (United States)

Seymour, Jennifer D; Yaroch, Amy Lazarus; Serdula, Mary; Blanck, Heidi Michels; Khan, Laura Kettel

2004-09-01

Nutrition interventions targeted to individuals are unlikely to significantly shift US dietary patterns as a whole. Environmental and policy interventions are more promising for shifting these patterns. We review interventions that influenced the environment through food availability, access, pricing, or information at the point-of-purchase in worksites, universities, grocery stores, and restaurants. Thirty-eight nutrition environmental intervention studies in adult populations, published between 1970 and June 2003, were reviewed and evaluated on quality of intervention design, methods, and description (e.g., sample size, randomization). No policy interventions that met inclusion criteria were found. Many interventions were not thoroughly evaluated or lacked important evaluation information. Direct comparison of studies across settings was not possible, but available data suggest that worksite and university interventions have the most potential for success. Interventions in grocery stores appear to be the least effective. The dual concerns of health and taste of foods promoted were rarely considered. Sustainability of environmental change was never addressed. Interventions in "limited access" sites (i.e., where few other choices were available) had the greatest effect on food choices. Research is needed using consistent methods, better assessment tools, and longer durations; targeting diverse populations; and examining sustainability. Future interventions should influence access and availability, policies, and macroenvironments.

Future of Automated Insulin Delivery Systems.

Science.gov (United States)

Castle, Jessica R; DeVries, J Hans; Kovatchev, Boris

2017-06-01

Advances in continuous glucose monitoring (CGM) have brought on a paradigm shift in the management of type 1 diabetes. These advances have enabled the automation of insulin delivery, where an algorithm determines the insulin delivery rate in response to the CGM values. There are multiple automated insulin delivery (AID) systems in development. A system that automates basal insulin delivery has already received Food and Drug Administration approval, and more systems are likely to follow. As the field of AID matures, future systems may incorporate additional hormones and/or multiple inputs, such as activity level. All AID systems are impacted by CGM accuracy and future CGM devices must be shown to be sufficiently accurate to be safely incorporated into AID. In this article, we summarize recent achievements in AID development, with a special emphasis on CGM sensor performance, and discuss the future of AID systems from the point of view of their input-output characteristics, form factor, and adaptability.

E-Skills of Delivery Managers

DEFF Research Database (Denmark)

Schlichter, Bjarne Rerup

Geographically distributed development of information systems calls for a set of specific skills among middle managers, facilitating outsourced services. With a theoretical point of departure and a resource-based view on strategy, this paper explores the e-skills of a group of so-called ‘Delivery...... Managers’ in this role. The paper contributes with a research model to understand the specific skills needed and points out communicative e-skills as being quite important. The paper concludes with suggestions for how to proceed the research....

Final environmental statement related to operation of Indian Point Nuclear Generating Plant, Unit No. 3: (Docket No. 50-286): Volume 1

International Nuclear Information System (INIS)

1975-02-01

The proposed action is the issuance of a license to consolidated Edison Company of New York, Inc., for the operation of the Indian Point Nuclear Generating Plant, Unit No. 3, located in the State of New York, Westchester County, Village of Buchanan, 24 miles north of the New York City boundary line. Although the present action is the issuance of an operating license for Unit No. 3, this Statement considers the environmental impacts from simultaneous operation of all three Units. A Final Environmental Statement has been issued for Unit No. 2. Furthermore, in view of the proximity to the Indian Point site of existing and presently proposed power plants on the Hudson River, the cumulative environmental benefits and impacts of the plants within a 30-mile reach of the river have been assessed. The proposed action is interreleated to other actions taken by other Federal agencies such as the Environmental Protection Agency, in regard to granting or denying application for discharge permits under the National Pollutant Discharge Elimination System (NPDES) instituted through the Federal Water Pollution Control Act Amendments of 1972, and the Federal Power Commission, in licensing of other facilities on the Hudson River. 128 figs., 210 tabs

The relationship between pregnancy, preterm and premature delivery

OpenAIRE

Soleymani-e- Shayesteh Y; Kamali-Nia Z

2002-01-01

During pregnancy, different froms of periodontal disease such as pregnancy gingivitis, pregnancy tumors, pregnancy stomatitis, may be encountered. But the most considerable point is the pregnant women's infection with periodontal disease and its effect on delivery and weight of newborn infants. Based on the latest researches and statistics, it is concluded that periodontal disease is an important risk factor, leading to preterm or premature delivery. On the other hand, poor hygiene, shou...

Applicable international environmental impact assessment laws for ...

African Journals Online (AJOL)

Lawrence Hart

1971-05-28

May 28, 1971 ... appraise selected International Environmental laws and the Nigerian Environmental Impact Assessment methodology ... maze of pipelines, delivery lines, flow lines, canals and .... Toxic Materials and international waterways.

User Involvement as a Configurable Integrated Product Delivery

DEFF Research Database (Denmark)

Vibæk, Kasper Sánchez

2009-01-01

as a configurable integrated product delivery then the architect can – using slightly provocatively a term from the production industry – be seen a configuration manager of processes shaping our physical surroundings. Products focusing on standardisation and mass customisation of the building process rather than......Integrated product deliveries as known from the product industry are beginning to emerge in construction. These are normally considered as physical systems that can be configured and customised for a specific delivery to form part of a unique construction project and help to reduce the complexity...... relevant field for development of customisable integrated product deliveries in construction. This development and its causes challenge the traditional role of the architect as the centre point in the creation of physical wholes or entireties. If user involvement, as argued, can be considered...

Archaeosomes: an excellent carrier for drug and cell delivery.

Science.gov (United States)

Kaur, Gurmeet; Garg, Tarun; Rath, Goutam; Goyal, Amit K

2016-09-01

Archaeosomes as liposomes made with one or more ether lipids that are unique to the domain of Archaeobacteria, found in Archaea constitute a novel family of liposome. Achaean-type lipids consist of archaeol (diether) and/or caldarchaeol (tetraether) core structures. Archaeosomes can be produced using standard procedures (hydrated film submitted to sonication, extrusion and detergent dialysis) at any temperature in the physiological range or lower, therefore making it possible to encapsulate thermally stable compounds. Various physiological as well as environmental factors affect its stability. Archaeosomes are widely used as drug delivery systems for cancer vaccines, Chagas disease, proteins and peptides, gene delivery, antigen delivery and delivery of natural antioxidant compounds. In this review article, our major aim was to explore the applications of this new carrier system in pharmaceutical field.

Environmental and energy benefits of freight delivery consolidation in urban area.

Science.gov (United States)

2013-03-01

Among new, innovative city logistics strategies, delivery cooperation has received increasing academic and : practical attention mostly in Europe and Japan. The idea is to establish cooperation among the suppliers, carriers : and the customers throug...

Pro SharePoint 2010 Business Intelligence Solutions

CERN Document Server

Malik, Sahil; Wright, Steve

2010-01-01

What differentiates good organizations from bad? The good ones are those that take advantage of the data they already have and use the feedback that business intelligence gives them to improve their processes. SharePoint is now the delivery platform of choice for Microsoft's business intelligence products, and in this book we reveal how to get the most from developing business intelligence solutions on SharePoint 2010. To understand the various business intelligence offerings in SharePoint 2010, you need to understand the core SQL Server business intelligence concepts, and the first part of th

Population-level correlates of preterm delivery among black and white women in the U.S.

Directory of Open Access Journals (Sweden)

Suzan L Carmichael

Full Text Available OBJECTIVE: This study examined the ability of social, demographic, environmental and health-related factors to explain geographic variability in preterm delivery among black and white women in the US and whether these factors explain black-white disparities in preterm delivery. METHODS: We examined county-level prevalence of preterm delivery (20-31 or 32-36 weeks gestation among singletons born 1998-2002. We conducted multivariable linear regression analysis to estimate the association of selected variables with preterm delivery separately for each preterm/race-ethnicity group. RESULTS: The prevalence of preterm delivery varied two- to three-fold across U.S. counties, and the distributions were strikingly distinct for blacks and whites. Among births to blacks, regression models explained 46% of the variability in county-level risk of delivery at 20-31 weeks and 55% for delivery at 32-36 weeks (based on R-squared values. Respective percentages for whites were 67% and 71%. Models included socio-environmental/demographic and health-related variables and explained similar amounts of variability overall. CONCLUSIONS: Much of the geographic variability in preterm delivery in the US can be explained by socioeconomic, demographic and health-related characteristics of the population, but less so for blacks than whites.

Efficient and gentle siRNA delivery by magnetofection

Science.gov (United States)

Ensenauer, R; Hartl, D; Vockley, J; Roscher, AA; Fuchs, U

2015-01-01

Magnetic force combined with magnetic nanoparticles recently has shown potential for enhancing nucleic acid delivery. Achieving effective siRNA delivery into primary cultured cells is challenging. We compared the utility of magnetofection with lipofection procedures for siRNA delivery to primary and immortalized mammalian fibroblasts. Transfection efficiency and cell viability were analyzed by flow cytometry and effects of gene knockdown were quantified by real-time PCR. Lipofectamine 2000 and magnetofection achieved high transfection efficiencies comparable to similar gene silencing effects of about 80%; the cytotoxic effect of magnetofection, however, was significantly less. Magnetofection is a reliable and gentle alternative method with low cytotoxicity for siRNA delivery into difficult to transfect cells such as mammalian fibroblasts. These features are especially advantageous for functional end point analyses of gene silencing, e.g., on the metabolite level. PMID:20297946

Out-Of-Pocket Expenditure on Institutional Delivery in Rural Lucknow

Directory of Open Access Journals (Sweden)

Mukesh Shukla

2015-06-01

Full Text Available   Introduction: Promotion of reproductive health through institutional delivery has been adopted by government as a strategy for reducing maternal mortality rate but still about half of the deliveries have been conducted at home. Cost barrier is one of the major cause for preferring home delivery instead of institutional delivery. Not only the direct costs responsible for low institutional delivery but also indirect costs too accountable for less number of institutional births in the country. Aims & Objectives: To estimate the out of pocket expenditure incurred by households during delivery and its determinants. Materials and methods: A community based cross sectional study was conducted during which a total 272 households having women who had recently delivered in government institutions were interviewed. Result: The mean out of pocket expenditure was found to be Rs. 1406.04 ± 103.27 including spending’s on drugs, travel, pathological tests and unofficial payments. Low socioeconomic class, residence outside the catchment area of delivery point, tertiary and secondary health care facilities as place of delivery and low literacy status of head of the family below high school  were found to be significantly associated with out of pocket expenditure bivariate analysis (p<0.05. On multivariate analysis low socioeconomic (OR 22.40; 95% CI 9.44-53.15; p = 0.01   and residence (OR 13.07; 95% CI (1.58-116.55; p = 0.03  outside the catchment area of delivery point were found to be independent predictors of catastrophic out of pocket expenditure during delivery. Conclusions: Although government has been running lot of schemes for availing free of cost health services but still one has to pay from their pocket as medical expenses. In order to bear these expenses, they have to borrow money, sell their assets and securities due to which households suffer a lot. In the present study, unofficial payment was found prevalent in public institutions

Out-Of-Pocket Expenditure on Institutional Delivery in Rural Lucknow

Directory of Open Access Journals (Sweden)

Mukesh Shukla

2015-06-01

Full Text Available AbstractIntroduction: Promotion of reproductive health through institutional delivery has been adopted by government as a strategy for reducing maternal mortality rate but still about half of the deliveries have been conducted at home. Cost barrier is one of the major cause for preferring home delivery instead of institutional delivery. Not only the direct costs responsible for low institutional delivery but also indirect costs too accountable for less number of institutional births in the country. Aims & Objectives: To estimate the out of pocket expenditure incurred by households during delivery and its determinants. Materials and methods: A community based cross sectional study was conducted during which a total 272 households having women who had recently delivered in government institutions were interviewed. Result: The mean out of pocket expenditure was found to be Rs. 1406.04 ± 103.27 including spending’s on drugs, travel, pathological tests and unofficial payments. Low socioeconomic class, residence outside the catchment area of delivery point, tertiary and secondary health care facilities as place of delivery and low literacy status of head of the family below high school  were found to be significantly associated with out of pocket expenditure bivariate analysis (p<0.05. On multivariate analysis low socioeconomic (OR 22.40; 95% CI 9.44-53.15; p = 0.01   and residence (OR 13.07; 95% CI (1.58-116.55; p = 0.03  outside the catchment area of delivery point were found to be independent predictors of catastrophic out of pocket expenditure during delivery. Conclusions: Although government has been running lot of schemes for availing free of cost health services but still one has to pay from their pocket as medical expenses. In order to bear these expenses, they have to borrow money, sell their assets and securities due to which households suffer a lot. In the present study, unofficial payment was found prevalent in public institutions

Random Forest-Based Approach for Maximum Power Point Tracking of Photovoltaic Systems Operating under Actual Environmental Conditions.

Science.gov (United States)

Shareef, Hussain; Mutlag, Ammar Hussein; Mohamed, Azah

2017-01-01

Many maximum power point tracking (MPPT) algorithms have been developed in recent years to maximize the produced PV energy. These algorithms are not sufficiently robust because of fast-changing environmental conditions, efficiency, accuracy at steady-state value, and dynamics of the tracking algorithm. Thus, this paper proposes a new random forest (RF) model to improve MPPT performance. The RF model has the ability to capture the nonlinear association of patterns between predictors, such as irradiance and temperature, to determine accurate maximum power point. A RF-based tracker is designed for 25 SolarTIFSTF-120P6 PV modules, with the capacity of 3 kW peak using two high-speed sensors. For this purpose, a complete PV system is modeled using 300,000 data samples and simulated using the MATLAB/SIMULINK package. The proposed RF-based MPPT is then tested under actual environmental conditions for 24 days to validate the accuracy and dynamic response. The response of the RF-based MPPT model is also compared with that of the artificial neural network and adaptive neurofuzzy inference system algorithms for further validation. The results show that the proposed MPPT technique gives significant improvement compared with that of other techniques. In addition, the RF model passes the Bland-Altman test, with more than 95 percent acceptability.

Research Plan: Foam Delivery of Remedial Amendments to Deep Vadose Zone for Metals and Radionuclides Remediation

International Nuclear Information System (INIS)

Zhong, Lirong; Hart, Andrea T.; Szecsody, James E.; Zhang, Z.F.; Freedman, Vicky L.; Ankeny, Mark; Hull, Laurence; Oostrom, Martinus; Freshley, Mark D.; Wellman, Dawn M.

2009-01-01

Research proposals were submitted to the Scientific and Technical Basis for In Situ Treatment of Metals and Radionuclides Technical Working Group under the US Department of Energy (DOE) Environmental Management Office (specifically, EM-22). After a peer review and selection process, the proposal, 'Foam Delivery of Remedial Amendments to Deep Vadose Zone for Metals and Radionuclides Remediation,' submitted by Pacific Northwest National Laboratory (PNNL) was selected for support by the program. A research plan was requested for this EM funded project. The overall objective of this project is to develop foam delivery technology for the distribution of remedial amendments to deep vadose zone sediments for in situ immobilization of metal and radionuclide contaminants. The focus of this research in FY 2009 is on the physical aspects of the foam delivery approach. Specific objectives are to (1) study the foam quality (i.e. the gas volume fraction in foam) influence on injection pressure, (2) study the sediment air permeability influence on injection pressure, (3) investigate liquid uptake in sediment and determine whether a water front will be formed during foam delivery, (4) test amendment distance (and mass) delivery by foam from the injection point, (5) study the enhanced sweeping over heterogeneous systems (i.e., low K zones) by foam delivery relative to water-based delivery under vadose zone conditions, and (6) numerically simulate foam delivery processes in the vadose zone. Laboratory scale experiments will be conducted at PNNL to study a range of basic physical aspects of the foam propagation in sediments, including foam quality and sediment permeability influence on injection pressure, liquid uptake, and foam sweeping across heterogeneous systems. This study will be augmented with separate studies to be conducted at MSE Technology Applications, Inc. (MSE) to evaluate foam transport and amendment delivery at the intermediate-scale. The results of intermediate

40 CFR 141.155 - Report delivery and recordkeeping.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Report delivery and recordkeeping. 141.155 Section 141.155 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Consumer Confidence Reports § 141.155...

A Survivable Wavelength Division Multiplexing Passive Optical Network with Both Point-to-Point Service and Broadcast Service Delivery

Science.gov (United States)

Ma, Xuejiao; Gan, Chaoqin; Deng, Shiqi; Huang, Yan

2011-11-01

A survivable wavelength division multiplexing passive optical network enabling both point-to-point service and broadcast service is presented and demonstrated. This architecture provides an automatic traffic recovery against feeder and distribution fiber link failure, respectively. In addition, it also simplifies the protection design for multiple services transmission in wavelength division multiplexing passive optical networks.

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine.

Science.gov (United States)

Jahangirian, Hossein; Lemraski, Ensieh Ghasemian; Webster, Thomas J; Rafiee-Moghaddam, Roshanak; Abdollahi, Yadollah

2017-01-01

This review discusses the impact of green and environmentally safe chemistry on the field of nanotechnology-driven drug delivery in a new field termed "green nanomedicine". Studies have shown that among many examples of green nanotechnology-driven drug delivery systems, those receiving the greatest amount of attention include nanometal particles, polymers, and biological materials. Furthermore, green nanodrug delivery systems based on environmentally safe chemical reactions or using natural biomaterials (such as plant extracts and microorganisms) are now producing innovative materials revolutionizing the field. In this review, the use of green chemistry design, synthesis, and application principles and eco-friendly synthesis techniques with low side effects are discussed. The review ends with a description of key future efforts that must ensue for this field to continue to grow.

Nanocarriers in ocular drug delivery: an update review.

Science.gov (United States)

Wadhwa, Sheetu; Paliwal, Rishi; Paliwal, Shivani Rai; Vyas, S P

2009-01-01

Controlled drug delivery to eye is one of the most challenging fields of pharmaceutical research. Low drug-contact time and poor ocular bioavailability due to drainage of solution, tear turnover and its dilution or lacrimation are the problems associated with conventional systems. In addition, anatomical barriers and physiological conditions of eye are also important parameters which control designing of drug delivery systems. Nanosized carriers like micro/nano-suspensions, liposome, niosome, dendrimer, nanoparticles, ocular inserts, implants, hydrogels and prodrug approaches have been developed for this purpose. These novel systems offer manifold advantages over conventional systems as they increase the efficiency of drug delivery by improving the release profile and also reduce drug toxicity. Conventional delivery systems get diluted with tear, washed away through the lacrimal gland and usually require administering at regular time intervals whereas nanocarriers release drug at constant rate for a prolonged period of time and thus enhance its absorption and site specific delivery. This review presents an overview of the various aspects of the ocular drug delivery, with special emphasis on nanocarrier based strategies, including structure of eye, its barriers, delivery routes and the challenges/limitations associated with development of novel nanocarriers. The recent progresses in therapy of ocular disease like gene therapy have also been included so that future options should also be considered from the delivery point of view. Recent progress in the delivery of proteins and peptides via ocular route has also been incorporated for reader benefit.

Carbon and energy footprints of electric delivery trucks:a hybrid multi-regional input-output life cycle assessment

OpenAIRE

Zhao, Yang; Onat, Nuri Cihat; Küçükvar, Murat; Tatari, Ömer

2016-01-01

Due to frequent stop-and-go operation and long idling periods when driving in congested urban areas, the electrification of commercial delivery trucks has become an interesting topic nationwide. In this study, environmental impacts of various alternative delivery trucks including battery electric, diesel, diesel-electric hybrid, and compressed natural gas trucks are analyzed. A novel life cycle assessment method, an environmentally-extended multi-region input-output analysis, is utilized to c...

Random Forest-Based Approach for Maximum Power Point Tracking of Photovoltaic Systems Operating under Actual Environmental Conditions

Directory of Open Access Journals (Sweden)

Hussain Shareef

2017-01-01

Full Text Available Many maximum power point tracking (MPPT algorithms have been developed in recent years to maximize the produced PV energy. These algorithms are not sufficiently robust because of fast-changing environmental conditions, efficiency, accuracy at steady-state value, and dynamics of the tracking algorithm. Thus, this paper proposes a new random forest (RF model to improve MPPT performance. The RF model has the ability to capture the nonlinear association of patterns between predictors, such as irradiance and temperature, to determine accurate maximum power point. A RF-based tracker is designed for 25 SolarTIFSTF-120P6 PV modules, with the capacity of 3 kW peak using two high-speed sensors. For this purpose, a complete PV system is modeled using 300,000 data samples and simulated using the MATLAB/SIMULINK package. The proposed RF-based MPPT is then tested under actual environmental conditions for 24 days to validate the accuracy and dynamic response. The response of the RF-based MPPT model is also compared with that of the artificial neural network and adaptive neurofuzzy inference system algorithms for further validation. The results show that the proposed MPPT technique gives significant improvement compared with that of other techniques. In addition, the RF model passes the Bland–Altman test, with more than 95 percent acceptability.

Environmental monitoring of phenolic pollutants in water by cloud point extraction prior to micellar electrokinetic chromatography.

Science.gov (United States)

Stege, Patricia W; Sombra, Lorena L; Messina, Germán A; Martinez, Luis D; Silva, María F

2009-05-01

Many aromatic compounds can be found in the environment as a result of anthropogenic activities and some of them are highly toxic. The need to determine low concentrations of pollutants requires analytical methods with high sensitivity, selectivity, and resolution for application to soil, sediment, water, and other environmental samples. Complex sample preparation involving analyte isolation and enrichment is generally necessary before the final analysis. The present paper outlines a novel, simple, low-cost, and environmentally friendly method for the simultaneous determination of p-nitrophenol (PNP), p-aminophenol (PAP), and hydroquinone (HQ) by micellar electrokinetic capillary chromatography after preconcentration by cloud point extraction. Enrichment factors of 180 to 200 were achieved. The limits of detection of the analytes for the preconcentration of 50-ml sample volume were 0.10 microg L(-1) for PNP, 0.20 microg L(-1) for PAP, and 0.16 microg L(-1) for HQ. The optimized procedure was applied to the determination of phenolic pollutants in natural waters from San Luis, Argentina.

Mucosal delivery of liposome-chitosan nanoparticle complexes.

Science.gov (United States)

Carvalho, Edison L S; Grenha, Ana; Remuñán-López, Carmen; Alonso, Maria José; Seijo, Begoña

2009-01-01

Designing adequate drug carriers has long been a major challenge for those working in drug delivery. Since drug delivery strategies have evolved for mucosal delivery as the outstanding alternative to parenteral administration, many new drug delivery systems have been developed which evidence promising properties to address specific issues. Colloidal carriers, such as nanoparticles and liposomes, have been referred to as the most valuable approaches, but still have some limitations that can become more inconvenient as a function of the specific characteristics of administration routes. To overcome these limitations, we developed a new drug delivery system that results from the combination of chitosan nanoparticles and liposomes, in an approach of combining their advantages, while avoiding their individual limitations. These lipid/chitosan nanoparticle complexes are, thus, expected to protect the encapsulated drug from harsh environmental conditions, while concomitantly providing its controlled release. To prepare these assemblies, two different strategies have been applied: one focusing on the simple hydration of a previously formed dry lipid film with a suspension of chitosan nanoparticles, and the other relying on the lyophilization of both basic structures (nanoparticles and liposomes) with a subsequent step of hydration with water. The developed systems are able to provide a controlled release of the encapsulated model peptide, insulin, evidencing release profiles that are dependent on their lipid composition. Moreover, satisfactory in vivo results have been obtained, confirming the potential of these newly developed drug delivery systems as drug carriers through distinct mucosal routes.

Impact of delivery mode on the colostrum microbiota composition.

Science.gov (United States)

Toscano, Marco; De Grandi, Roberta; Peroni, Diego Giampietro; Grossi, Enzo; Facchin, Valentina; Comberiati, Pasquale; Drago, Lorenzo

2017-09-25

Breast milk is a rich nutrient with a temporally dynamic nature. In particular, numerous alterations in the nutritional, immunological and microbiological content occur during the transition from colostrum to mature milk. The objective of our study was to evaluate the potential impact of delivery mode on the microbiota of colostrum, at both the quantitative and qualitative levels (bacterial abundance and microbiota network). Twenty-nine Italian mothers (15 vaginal deliveries vs 14 Cesarean sections) were enrolled in the study. The microbiota of colostrum samples was analyzed by next generation sequencing (Ion Torrent Personal Genome Machine). The colostrum microbiota network associated with Cesarean section and vaginal delivery was evaluated by means of the Auto Contractive Map (AutoCM), a mathematical methodology based on Artificial Neural Network (ANN) architecture. Numerous differences between Cesarean section and vaginal delivery colostrum were observed. Vaginal delivery colostrum had a significant lower abundance of Pseudomonas spp., Staphylococcus spp. and Prevotella spp. when compared to Cesarean section colostrum samples. Furthermore, the mode of delivery had a strong influence on the microbiota network, as Cesarean section colostrum showed a higher number of bacterial hubs if compared to vaginal delivery, sharing only 5 hubs. Interestingly, the colostrum of mothers who had a Cesarean section was richer in environmental bacteria than mothers who underwent vaginal delivery. Finally, both Cesarean section and vaginal delivery colostrum contained a greater number of anaerobic bacteria genera. The mode of delivery had a large impact on the microbiota composition of colostrum. Further studies are needed to better define the meaning of the differences we observed between Cesarean section and vaginal delivery colostrum microbiota.

Effects of environmental conditions on point-of-care cardiac biomarker test performance during a simulated rescue: implications for emergency and disaster response.

Science.gov (United States)

Louie, Richard F; Ferguson, William J; Curtis, Corbin M; Vy, John H; Tang, Chloe S; Kost, Gerald J

2013-01-01

To characterize the effects of environmental stress on point-of-care (POC) cardiac biomarker testing during a simulated rescue. Multiplex test cassettes for cardiac troponin I (cTnI), brain natriuretic peptide (BNP), CK-MB, myoglobin, and D-dimer were exposed to environmental stresses simulating a 24-hour rescue from Hawaii to the Marshall Islands and back. We used Tenney environmental chambers (T2RC and BTRC) to simulate flight conditions (20°C, 10 percent relative humidity) and ground conditions (22.3-33.9°C, 73-77 percent). We obtained paired measurements using stressed versus control (room temperature) cassettes at seven time points (T1-7 with T1,2,6,7 during flight and T3-5 on ground). We analyzed paired differences (stressed minus control) with Wilcoxon signed rank test. We assessed the impact on decision-making at clinical thresholds. cTnI results from stressed test cassettes (n = 10) at T4 (p 100 ng/L. With sample median concentration of 108 pg/mL, BNP results from stressed test cassettes differed significantly from controls (p < 0.05). Despite modest, short-term temperature elevation, environmental stresses led to erroneous results. False negative cTnI and BNP results potentially could miss acute myocardial infarction and congestive heart failure, confounded treatment, and increased mortality and morbidity. Therefore, rescuers should protect POC reagents from temperature extremes.

Radiation dose delivery verification in the treatment of carcinoma-cervix

International Nuclear Information System (INIS)

Shrotriya, D.; Srivastava, R. N. L.; Kumar, S.

2015-01-01

The accurate dose delivery to the clinical target volume in radiotherapy can be affected by various pelvic tissues heterogeneities. An in-house heterogeneous woman pelvic phantom was designed and used to verify the consistency and computational capability of treatment planning system of radiation dose delivery in the treatment of cancer cervix. Oncentra 3D-TPS with collapsed cone convolution (CCC) dose calculation algorithm was used to generate AP/PA and box field technique plan. the radiation dose was delivered by Primus Linac (Siemens make) employing high energy 15 MV photon beam by isocenter technique. A PTW make, 0.125cc ionization chamber was used for direct measurements at various reference points in cervix, bladder and rectum. The study revealed that maximum variation between computed and measured dose at cervix reference point was 1% in both the techniques and 3% and 4% variation in AP/PA field and 5% and 4.5% in box technique at bladder and rectum points respectively

Radiation dose delivery verification in the treatment of carcinoma-cervix

Science.gov (United States)

Shrotriya, D.; Kumar, S.; Srivastava, R. N. L.

2015-06-01

The accurate dose delivery to the clinical target volume in radiotherapy can be affected by various pelvic tissues heterogeneities. An in-house heterogeneous woman pelvic phantom was designed and used to verify the consistency and computational capability of treatment planning system of radiation dose delivery in the treatment of cancer cervix. Oncentra 3D-TPS with collapsed cone convolution (CCC) dose calculation algorithm was used to generate AP/PA and box field technique plan. the radiation dose was delivered by Primus Linac (Siemens make) employing high energy 15 MV photon beam by isocenter technique. A PTW make, 0.125cc ionization chamber was used for direct measurements at various reference points in cervix, bladder and rectum. The study revealed that maximum variation between computed and measured dose at cervix reference point was 1% in both the techniques and 3% and 4% variation in AP/PA field and 5% and 4.5% in box technique at bladder and rectum points respectively.

Radiation dose delivery verification in the treatment of carcinoma-cervix

Energy Technology Data Exchange (ETDEWEB)

Shrotriya, D., E-mail: shrotriya2007@gmail.com; Srivastava, R. N. L. [Department of Radiotherapy, J.K. Cancer Institute Kanpur-208019 (India); Kumar, S. [Department of Physics, Christ Church College, Kanpur-208001 (India)

2015-06-24

The accurate dose delivery to the clinical target volume in radiotherapy can be affected by various pelvic tissues heterogeneities. An in-house heterogeneous woman pelvic phantom was designed and used to verify the consistency and computational capability of treatment planning system of radiation dose delivery in the treatment of cancer cervix. Oncentra 3D-TPS with collapsed cone convolution (CCC) dose calculation algorithm was used to generate AP/PA and box field technique plan. the radiation dose was delivered by Primus Linac (Siemens make) employing high energy 15 MV photon beam by isocenter technique. A PTW make, 0.125cc ionization chamber was used for direct measurements at various reference points in cervix, bladder and rectum. The study revealed that maximum variation between computed and measured dose at cervix reference point was 1% in both the techniques and 3% and 4% variation in AP/PA field and 5% and 4.5% in box technique at bladder and rectum points respectively.

The relationship between pregnancy, preterm and premature delivery

Directory of Open Access Journals (Sweden)

Soleymani-e- Shayesteh Y

2002-06-01

Full Text Available During pregnancy, different froms of periodontal disease such as pregnancy gingivitis, pregnancy tumors, pregnancy stomatitis, may be encountered. But the most considerable point is the pregnant women's infection with periodontal disease and its effect on delivery and weight of newborn infants. Based on the latest researches and statistics, it is concluded that periodontal disease is an important risk factor, leading to preterm or premature delivery. On the other hand, poor hygiene, should be considered as another danger, resulting in premature delivery. Besides, the presence of a collection of oral fosobacteria in ammoniutic fluid in mothers with premature delivery, increases the probability of an oral- haematogenous connection. Moreover, prostaglandin E2, in cervicular fluid, has been considered as an index for periodontal disease activity and loss of weight at the time of birth. These findings suggest that effective steps, to prevent preterm delivery, can be taken, if women, genycologists and dentists have enough knowledge. This article focuses on the special supervision that is required to prevent the effects of hormonal changes on periodontal tissues and conversely to reduce systemic disorders resulting from periodontal disease, in pregnant woman.

Nano/Micro Formulations for Bacteriophage Delivery.

Science.gov (United States)

Cortés, Pilar; Cano-Sarabia, Mary; Colom, Joan; Otero, Jennifer; Maspoch, Daniel; Llagostera, Montserrat

2018-01-01

Encapsulation methodologies allow the protection of bacteriophages for overcoming critical environmental conditions. Moreover, they improve the stability and the controlled delivery of bacteriophages which is of great innovative value in bacteriophage therapy. Here, two different encapsulation methodologies of bacteriophages are described using two biocompatible materials: a lipid cationic mixture and a combination of alginate with the antacid CaCO 3 . To perform bacteriophage encapsulation, a purified lysate highly concentrated (around 10 10 -10 11  pfu/mL) is necessary, and to dispose of a specific equipment. Both methodologies have been successfully applied for encapsulating Salmonella bacteriophages with different morphologies. Also, the material employed does not modify the antibacterial action of bacteriophages. Moreover, both technologies can also be adapted to any bacteriophage and possibly to any delivery route for bacteriophage therapy.

Analysis of point source pollution and water environmental quality variation trends in the Nansi Lake basin from 2002 to 2012.

Science.gov (United States)

Wang, Weiliang; Liu, Xiaohui; Wang, Yufan; Guo, Xiaochun; Lu, Shaoyong

2016-03-01

Based on the data analysis of the water environmental quality and economic development from 2002 to 2012 in the Nansi Lake basin, the correlation and change between the water environmental quality and economic development were studied. Results showed that the GDP and wastewater emissions of point source in the Nansi Lake basin had an average annual growth of 7.30 and 7.68 %, respectively, from 2002 to 2012. The emissions of chemical oxygen demand (COD) and ammonia nitrogen (NH3-N) had the average annual decrease of 7.69 and 6.79 % in 2012, respectively, compared to 2002. Basin water quality overall improved, reaching the Class III of the "Environmental quality standards for surface water (GB3838-2002)," in which the main reason was that sewage treatment rate increased gradually and was above 90 % in 2012 (an increase of 10 % compared to 2002) with the progress of pollution abatement technology and the implementation of relevant policies and regulations. The contribution of water environmental pollution was analyzed from related cities (Ji'ning, Zaozhuang, Heze). Results indicated that Ji'ning had the largest contribution to water pollution of the Nansi Lake basin, and the pollutant from domestic sources accounted for a higher percentage compared to industrial sources. The wastewater, COD, and NH3-N mainly came from mining and washing of coal, manufacture of raw chemical materials and chemical products, papermaking industry, and food processing industry. According to the water pollution characteristics of the Nansi Lake basin, the basin pollution treatment strategy and prevention and treatment system were dissected to provide a scientific basis for prevention and control of lakeside point source pollution along the Nansi Lake.

Maximum power point tracking algorithm based on sliding mode and fuzzy logic for photovoltaic sources under variable environmental conditions

Science.gov (United States)

Atik, L.; Petit, P.; Sawicki, J. P.; Ternifi, Z. T.; Bachir, G.; Della, M.; Aillerie, M.

2017-02-01

Solar panels have a nonlinear voltage-current characteristic, with a distinct maximum power point (MPP), which depends on the environmental factors, such as temperature and irradiation. In order to continuously harvest maximum power from the solar panels, they have to operate at their MPP despite the inevitable changes in the environment. Various methods for maximum power point tracking (MPPT) were developed and finally implemented in solar power electronic controllers to increase the efficiency in the electricity production originate from renewables. In this paper we compare using Matlab tools Simulink, two different MPP tracking methods, which are, fuzzy logic control (FL) and sliding mode control (SMC), considering their efficiency in solar energy production.

Evaluation of cross-linked gelatin membranes as delivery carriers for retinal sheets

Energy Technology Data Exchange (ETDEWEB)

Lai, Jui-Yang, E-mail: jylai@mail.cgu.edu.tw [Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, 33302 Taiwan (China); Biomedical Engineering Research Center, Chang Gung University, Taoyuan, 33302 Taiwan (China); Molecular Medicine Research Center, Chang Gung University, Taoyuan, 33302 Taiwan (China); Li, Ya-Ting [Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, 33302 Taiwan (China)

2010-06-15

The delivery of intact sheet transplants to the subretinal space can prevent cell loss that is generally associated with the injection of cell suspensions or cell aggregates. The aim of this study was to develop chemically modified gelatin matrices that enhance the delivery efficiency and analyze whether the gelatin membranes cross-linked with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) can be considered as potential carriers for retinal sheets. The characteristics of EDC cross-linked gelatin membranes were determined by mechanical and in vitro degradation tests, melting point measurements, cell proliferation assays, cytokine expression analyses, and tissue delivery studies. Gelatin membranes without cross-linking and glutaraldehyde cross-linked gelatin samples were used for comparison. Results of this study indicated that introduction of cross-links is capable of rendering the gelatin network more stable against mechanical stresses and deformations as well as rapid hydrolysis during intraocular delivery of delicate tissue sheets. In comparison with the glutaraldehyde treated samples, the EDC cross-linked gelatin membranes showed a better degradation profile and a relatively higher cytocompatibility. In addition, after EDC cross-linking, the gelatin matrices having an acceptable melting point could be used for the fabrication of a sandwich-like carrier with a high transfer and encapsulation efficiency. These findings suggest that the cross-linking agent type gives an influence on delivery functionality of gelatin membranes. In summary, the EDC cross-linked gelatin is an ideal candidate for use as a carrier material in retinal sheet delivery applications.

Project Delivery System Mode Decision Based on Uncertain AHP and Fuzzy Sets

Science.gov (United States)

Kaishan, Liu; Huimin, Li

2017-12-01

The project delivery system mode determines the contract pricing type, project management mode and the risk allocation among all participants. Different project delivery system modes have different characteristics and applicable scope. For the owners, the selection of the delivery mode is the key point to decide whether the project can achieve the expected benefits, it relates to the success or failure of project construction. Under the precondition of comprehensively considering the influence factors of the delivery mode, the model of project delivery system mode decision was set up on the basis of uncertain AHP and fuzzy sets, which can well consider the uncertainty and fuzziness when conducting the index evaluation and weight confirmation, so as to rapidly and effectively identify the most suitable delivery mode according to project characteristics. The effectiveness of the model has been verified via the actual case analysis in order to provide reference for the construction project delivery system mode.

Alternative Public Service Delivery Models in Health, Water and ...

International Development Research Centre (IDRC) Digital Library (Canada)

This project seeks to analyze health, water and electricity delivery models in Africa, Asia and Latin America in order to identify and document successful alternatives to commercialization. Researchers will draw up a set of ... Documents. Environmental and water management law in post-apartheid South Africa. Documents.

Bulk Fuel Storage and Delivery Systems Infrastructure Military Construction Requirements for Japan

National Research Council Canada - National Science Library

Padgett, Gary

2000-01-01

This report is one in a series that addresses the accuracy and reliability of maintenance, repair, and environmental and construction requirements for bulk fuel storage and delivery systems infrastructure...

Environmental indicators for buildings

DEFF Research Database (Denmark)

Dammann, Sven

Environmental Indicators for Buildings are studied using two different perspectives: with a technological, environmental scientific departing point and with a social scientific departing point. Different relevant groups in the building sector are identified and analysed, using the Social...

Design, development and characterization of multi-functionalized gold nanoparticles for biodetection and targeted boron delivery in BNCT applications

Energy Technology Data Exchange (ETDEWEB)

Mandal, Subhra [Department of Tumor Immunology, Radboud University Nijmegen Medical Centre (Netherlands); Bakeine, Gerald J., E-mail: Jamesbakeine1@yahoo.com [Department of Internal Medicine and Therapeutics-Section of Clinical Toxicology, University of Pavia, Piazza Botta 10, 27100 Pavia (Italy); Krol, Silke [Institute of Neurology, Fondazione IRCCS Carlo Besta, Milan (Italy); Ferrari, Cinzia; Clerici, Anna M.; Zonta, Cecilia; Cansolino, Laura [Department of Surgery, Laboratory of Experimental Surgery, University of Pavia (Italy); Ballarini, Francesca [Department of Nuclear and Theoretical Physics, University of Pavia (Italy); Bortolussi, Silva [Department of Nuclear and Theoretical Physics, University of Pavia (Italy)] [National Institute of Nuclear Physics (INFN), Section of Pavia (Italy); Stella, Subrina; Protti, Nicoletta [Department of Nuclear and Theoretical Physics, University of Pavia (Italy); Bruschi, Piero [National Institute of Nuclear Physics (INFN), Section of Pavia (Italy); Altieri, Saverio [Department of Nuclear and Theoretical Physics, University of Pavia (Italy)] [National Institute of Nuclear Physics (INFN), Section of Pavia (Italy)

2011-12-15

The aim of this study is to optimize targeted boron delivery to cancer cells and its tracking down to the cellular level. To this end, we describe the design and synthesis of novel nanovectors that double as targeted boron delivery agents and fluorescent imaging probes. Gold nanoparticles were coated with multilayers of polyelectrolytes functionalized with the fluorescent dye (FITC), boronophenylalanine and folic acid. In vitro confocal fluorescence microscopy demonstrated significant uptake of the nanoparticles in cancer cells that are known to overexpress folate receptors. - Highlights: Black-Right-Pointing-Pointer Synthesis of multi-labeled gold nanoparticles for selective boron delivery to tumor cells. Black-Right-Pointing-Pointer Tumor selectivity is achieved through folic acid receptor targeting. Black-Right-Pointing-Pointer Optical fluorescent microscopy allows tracking of cellular uptake of the gold nanoparticle. Black-Right-Pointing-Pointer In vitro tests demonstrate selective nanoparticle up in folate receptor positive tumor cells.

Point of Care Testing Services Delivery: Policy Analysis using a ...

African Journals Online (AJOL)

Annals of Biomedical Sciences ... The service providers (hospital management) and the testing personnel are faced with the task of trying to explain these problems. Objective of the study: To critically do a policy analysis of the problems of point of care testing with the aim of identifying the causes of these problems and ...

Economic Evidence and Point-of-Care Testing

Science.gov (United States)

St John, Andrew; Price, Christopher P

2013-01-01

Health economics has been an established feature of the research, policymaking, practice and management in the delivery of healthcare. However its role is increasing as the cost of healthcare begins to drive changes in most healthcare systems. Thus the output from cost effectiveness studies is now being taken into account when making reimbursement decisions, e.g. in Australia and the United Kingdom. Against this background it is also recognised that the health economic tools employed in healthcare, and particularly the output from the use of these tools however, are not always employed in the routine delivery of services. One of the notable consequences of this situation is the poor record of innovation in healthcare with respect to the adoption of new technologies, and the realisation of their benefits. The evidence base for the effectiveness of diagnostic services is well known to be limited, and one consequence of this has been a very limited literature on cost effectiveness. One reason for this situation is undoubtedly the reimbursement strategies employed in laboratory medicine for many years, simplistically based on the complexity of the test procedure, and the delivery as a cost-per-test service. This has proved a disincentive to generate the required evidence, and little effort to generate an integrated investment and disinvestment business case, associated with care pathway changes. Point-of-care testing creates a particularly challenging scenario because, on the one hand, the unit cost-per-test is larger through the loss of the economy of scale offered by automation, whilst it offers the potential of substantial savings through enabling rapid delivery of results, and reduction of facility costs. This is important when many health systems are planning for complete system redesign. We review the literature on economic assessment of point-of-care testing in the context of these developments. PMID:24151342

The relationship between occupational fatigue and preterm delivery

Directory of Open Access Journals (Sweden)

Mahbod Ebrahimi

2014-05-01

Full Text Available Background: The presense of women in workplace is an unavoiding issue in modern world. The women work in different media. Occupational activities are suspected of having an adverse impact on outcomes of pregnancy. Premature delivery is a catastrophic event in course of pregnancy. The aim of the study was to define the incidence of premature delivery in occupationally involved pregnant women. Material and Methods: A total of 287 primigravida women in an urban society with singleton pregnancies at 22 to 24 weeks gestation were enrolled in a prospective study. They worked in industrial manufactures. The patients reported the number of hours worked per week and answered specific questions designed to determine the following 5 sources of occupational fatigue including:1- posture ,2- work with industrial machines 3- physical exertion 4-mental stress and 5- environmental stress. Results: The risk of preterm delivery increased with standing more than 3 hours during activities in work place (p.value=0/019. There was not a statistically significant relationship between premature delivery and other sources of occupational fatigue. There was not a statically significant relationship between premature rupture of fetal membranes and the sources of occupational fatigue. There was not a statistically significant relationship between premature delivery and increasing number of hours worked per week. Conclusion: The relationship between premature delivery and occupational fatigue may provide guidelines according to pregnant women and their employers can be advised.

IMPROVEMENTS IN THE QUALITY OF COURIER DELIVERY

Directory of Open Access Journals (Sweden)

Jacek Karcz

2016-06-01

Full Text Available The functioning of courier companies is a vital component of modern trade. E-commerce services are changing the way of shopping. Along with them, also courier services change and become more advance. Customers of courier companies become more aware of quality, which they should expect from supplier of these services. The article presents the result of the research of the effectiveness and the timelines of deliveries realized by one of the terminals of a leading courier operator in Poland. The survey involved 55 courier routes over the course of 10 business days. The author analyses weak points of the supply chain and presents two solutions, which may improve quality of delivery processes.

Environmental implications of wireless technologies: news delivery and business meetings.

Science.gov (United States)

Toffel, Michael W; Horvath, Arpad

2004-06-01

Wireless information technologies are providing new ways to communicate, and are one of several information and communication technologies touted as an opportunity to reduce society's overall environmental impacts. However, rigorous system-wide environmental impact comparisons of these technologies to the traditional applications they may replace have only recently been initiated, and the results have been mixed. In this paper, the environmental effects of two applications of wireless technologies are compared to those of conventional technologies for which they can substitute. First, reading newspaper content on a personal digital assistant (PDA) is compared to the traditional way of reading a newspaper. Second, wireless teleconferencing is compared to business travel. The results show that for both comparisons wireless technologies create lower environmental impacts. Compared to reading a newspaper, receiving the news on a PDA wirelessly results in the release of 32-140 times less CO2, several orders of magnitude less NOx and SOx, and the use of 26-67 times less water. Wireless teleconferencing results in 1-3 orders of magnitude lower CO2, NOx, and SO2 emissions than business travel.

Preparation and characterization of magnetic gene vectors for targeting gene delivery

Energy Technology Data Exchange (ETDEWEB)

Zheng, S.W.; Liu, G. [College of Chemistry, Chemical Engineering and Materials Science and Key Laboratory of Organic Synthesis of Jiangsu Province, Soochow University, SIP, Suzhou 215123 (China); Hong, R.Y., E-mail: rhong@suda.edu.cn [College of Chemistry, Chemical Engineering and Materials Science and Key Laboratory of Organic Synthesis of Jiangsu Province, Soochow University, SIP, Suzhou 215123 (China); State Key Laboratory of Multi-phase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080 (China); Li, H.Z. [State Key Laboratory of Multi-phase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080 (China); Li, Y.G., E-mail: ilguoliang@sohu.com [Department of radiology, the First Affiliated Hospital of Soochow University, Suzhou 215007 (China); Wei, D.G., E-mail: dougwei@deas.harvard.edu [Center for Nanoscale Systems, School of Engineering and Applied Science, Harvard University, 11 Oxford Street, Cambridge, MA 02139 (United States)

2012-10-15

Highlights: Black-Right-Pointing-Pointer PEI is ideal candidate polymer for the design of gene delivery systems. Black-Right-Pointing-Pointer PEI-CMD-MNPs exhibited a typical superparamagnetic behavior. Black-Right-Pointing-Pointer PEI-CMD-MNPs were well stable over the entire range of pH and NaCl concentration. Black-Right-Pointing-Pointer DNA-PEI-CMD-MNPs transfected cells by a magnet have higher transfection efficiency and gene expression efficiency. - Abstract: The PEI-CMD-MNPs were successfully prepared by the surface modification of magnetic Fe{sub 3}O{sub 4} nanoparticles with carboxymethyl dextran (CMD) and polyethyleneimine (PEI). The PEI-CMD-MNPs polyplexes exhibited a typical superparamagnetic behavior and were well stable over the entire range of pH and NaCl concentration. These PEI-CMD-MNPs were used as magnetic gene vectors for targeting gene delivery. The prepared MNPs at different surface modification stages were characterized using Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), field emissions canning electron microscopy (FE-SEM), powder X-ray diffraction (XRD) and dynamic laser light scattering (DLS) analysis. The magnetic properties were studied by vibrating sample magnetometer (VSM). To evaluate the performance of the magnetic nanoparticles as gene transfer vector, the PEI-CMD-MNPs were used to delivery green fluorescent protein (GFP) gene into BHK21 cells. The expression of GFP gene was detected by fluorescence microscope. DNA-PEI-CMD-MNPs polyplexes absorbed by the cells were also monitored by Magnetic resonance imaging (MRI). The transfection efficiency and gene expression efficiency of that transfected with a magnet were much higher than that of standard transfection.

The Small Area Health Statistics Unit: a national facility for investigating health around point sources of environmental pollution in the United Kingdom.

Science.gov (United States)

Elliott, P; Westlake, A J; Hills, M; Kleinschmidt, I; Rodrigues, L; McGale, P; Marshall, K; Rose, G

1992-01-01

STUDY OBJECTIVE--The Small Area Health Statistics Unit (SAHSU) was established at the London School of Hygiene and Tropical Medicine in response to a recommendation of the enquiry into the increased incidence of childhood leukaemia near Sellafield, the nuclear reprocessing plant in West Cumbria. The aim of this paper was to describe the Unit's methods for the investigation of health around point sources of environmental pollution in the United Kingdom. DESIGN--Routine data currently including deaths and cancer registrations are held in a large national database which uses a post code based retrieval system to locate cases geographically and link them to the underlying census enumeration districts, and hence to their populations at risk. Main outcome measures were comparison of observed/expected ratios (based on national rates) within bands delineated by concentric circles around point sources of environmental pollution located anywhere in Britain. MAIN RESULTS--The system is illustrated by a study of mortality from mesothelioma and asbestosis near the Plymouth naval dockyards during 1981-87. Within a 3 km radius of the docks the mortality rate for mesothelioma was higher than the national rate by a factor of 8.4, and that for asbestosis was higher by a factor of 13.6. CONCLUSIONS--SAHSU is a new national facility which is rapidly able to provide rates of mortality and cancer incidence for arbitrary circles drawn around any point in Britain. The example around Plymouth of mesothelioma and asbestosis demonstrates the ability of the system to detect an unusual excess of disease in a small locality, although in this case the findings are likely to be related to occupational rather than environmental exposure. PMID:1431704

Elastin-Like Recombinamers As Smart Drug Delivery Systems.

Science.gov (United States)

Arias, F Javier; Santos, Mercedes; Ibanez-Fonseca, Arturo; Pina, Maria Jesus; Serrano, Sofía

2018-02-19

Drug delivery systems that are able to control the release of bioactive molecules and designed to carry drugs to target sites are of particular interest for tissue therapy. Moreover, systems comprising materials that can respond to environmental stimuli and promote self-assembly and higher order supramolecular organization are especially useful in the biomedical field. Objetive: This review focuses on biomaterials suitable for this purpose and that include elastin-like recombinamers (ELRs), a class of proteinaceous polymers bioinspired by natural elastin, designed using recombinant technologies. The self-assembly and thermoresponsive behaviour of these systems, along with their biodegradability, biocompatibility and well-defined composition as a result of their tailormade design, make them particularly attractive for controlled drug delivery. ELR-based delivery systems that allow targeted delivery are reviewed, especially ELR-drug recombinant fusion constructs, ELR-drug systems chemically bioconjugated in their monomeric and soluble forms, and drug encapsulation by nanoparticle-forming ELRs. Subsequently, the review focuses on those drug carriers in which smart release is triggered by pH or temperature with a particular focus on cancer treatments. Systems for controlled drug release based on depots and hydrogels that act as both a support and reservoir in which drugs can be stored will be described, and their applications in drug delivery discussed. Finally, smart drug-delivery systems not based on ELRs, including those comprising proteins, synthetic polymers and non-polymeric systems, will also be briefly discussed. Several different constructions based on ELRs are potential candidates for controlled drug delivery to be applied in advanced biomedical treatments. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Environmental ethics - connections between the environmental protection movement and the churches

International Nuclear Information System (INIS)

Breuer, W.

1986-01-01

The crisis of the environment as a part of a much more comprehensive, deeper crisis of man in modern civilization - this, and the question for the causes of the crisis are the subjects of the book. Focal points of environmental ethics which are also points establishing a connection to the churches - brown coal open-pit mining in the Rhine-and-Ruhr district, the nuclear power plant site Pfaffenhofen, and road planning in the Rinnebach valley - continue the introductory part on 'Environment and christianity'. 'Perspectives of environmental ethics' draw up a conceptional framework to consider environmental ethics in the discussion about environmental politics. (HSCH) [de

Environmental report 97

International Nuclear Information System (INIS)

Verbund

1997-01-01

This is a report of the Austrian electricity company (VERBUND) which treats environmental topics. 1. First of all the water power technology in Austria is discussed, thereby the following subjects are pointed out: energy efficiency, water economy and water ecology, groundwater management, environmental protection. 2. Thermal power technology: basic numerical data from thermal power stations, energy efficiency, energy optimization, pollution of air and in the hydrosphere. 3. Network facilities: problems in the landscape, ecological point of view, electric and magnetic field protection. The aims of environmental management are discussed. (author)

Peptide and protein delivery using new drug delivery systems.

Science.gov (United States)

Jain, Ashish; Jain, Aviral; Gulbake, Arvind; Shilpi, Satish; Hurkat, Pooja; Jain, Sanjay K

2013-01-01

Pharmaceutical and biotechnological research sorts protein drug delivery systems by importance based on their various therapeutic applications. The effective and potent action of the proteins/peptides makes them the drugs of choice for the treatment of numerous diseases. Major research issues in protein delivery include the stabilization of proteins in delivery devices and the design of appropriate target-specific protein carriers. Many efforts have been made for effective delivery of proteins/peptidal drugs through various routes of administrations for successful therapeutic effects. Nanoparticles made of biodegradable polymers such as poly lactic acid, polycaprolactone, poly(lactic-co-glycolic acid), the poly(fumaric-co-sebacic) anhydride chitosan, and modified chitosan, as well as solid lipids, have shown great potential in the delivery of proteins/peptidal drugs. Moreover, scientists also have used liposomes, PEGylated liposomes, niosomes, and aquasomes, among others, for peptidal drug delivery. They also have developed hydrogels and transdermal drug delivery systems for peptidal drug delivery. A receptor-mediated delivery system is another attractive strategy to overcome the limitation in drug absorption that enables the transcytosis of the protein across the epithelial barrier. Modification such as PEGnology is applied to various proteins and peptides of the desired protein and peptides also increases the circulating life, solubility and stability, pharmacokinetic properties, and antigenicity of protein. This review focuses on various approaches for effective protein/peptidal drug delivery, with special emphasis on insulin delivery.

Environmental Monitoring of Agro-Ecosystem Using Environmental Isotope Tracer Technology

International Nuclear Information System (INIS)

Chung, Byung Yeoup; Kim, Jae Sung; Cho, Jae Young

2004-10-01

This report has provided the counterparts the knowledge and skills on the use of environmental isotope tracer technology for obtaining valuable information on agricultural non-point pollution source in agro-ecosystem. The contamination from agricultural watersheds has been brought into attention as a potential contaminant of streams and tributaries, since majority of them caused water quality degradation, eutrophication of reservoir and negative effect on agro-environment. To prevent the contamination from these watersheds, it is necessary to find out the source of the contamination. However, accurate contaminants outflows from various types of non-point sources have not yet been elucidated due to the fact that the extent of non-point source contaminants related to uncontrollable climatic events and irrigation conditions may differ greatly from place to place and year to year. The dominant use of isotopes in environmental ecosystem research in the last few decades has been to trace sources of waters and solutes. The environmental isotope tracer technology using stable isotopes such as oxygen, hydrogen, carbon, nitrogen, and sulfur has extensively been used for tracing the fate of environmental pollutants and for identification of environmental pollutants sources in agro-ecosystems

Assessing delivery practices of mothers over time and over space in Uganda, 2003-2012.

Science.gov (United States)

Sprague, Daniel A; Jeffery, Caroline; Crossland, Nadine; House, Thomas; Roberts, Gareth O; Vargas, William; Ouma, Joseph; Lwanga, Stephen K; Valadez, Joseph J

2016-01-01

It is well known that safe delivery in a health facility reduces the risks of maternal and infant mortality resulting from perinatal complications. What is less understood are the factors associated with safe delivery practices. We investigate factors influencing health facility delivery practices while adjusting for multiple other factors simultaneously, spatial heterogeneity, and trends over time. We fitted a logistic regression model to Lot Quality Assurance Sampling (LQAS) data from Uganda in a framework that considered individual-level covariates, geographical features, and variations over five time points. We accounted for all two-covariate interactions and all three-covariate interactions for which two of the covariates already had a significant interaction, were able to quantify uncertainty in outputs using computationally intensive cluster bootstrap methods, and displayed outputs using a geographical information system. Finally, we investigated what information could be predicted about districts at future time-points, before the next LQAS survey is carried out. To do this, we applied the model to project a confidence interval for the district level coverage of health facility delivery at future time points, by using the lower and upper end values of known demographics to construct a confidence range for the prediction and define priority groups. We show that ease of access, maternal age and education are strongly associated with delivery in a health facility; after accounting for this, there remains a significant trend towards greater uptake over time. We use this model together with known demographics to formulate a nascent early warning system that identifies candidate districts expected to have low prevalence of facility-based delivery in the immediate future. Our results support the hypothesis that increased development, particularly related to education and access to health facilities, will act to increase facility-based deliveries, a factor

Power delivery in the 21. century : part 1, getting electricity from the point of generation to the point of use

International Nuclear Information System (INIS)

Douglas, J.

2000-01-01

The challenges facing the U.S. electric power industry in meeting the power quality demands of a digital society were discussed. The management of power delivery will become increasingly difficult as power loading continues to grow with deregulation. The 1992 Energy Policy Act required open access to utility transmission lines, while Orders 888 and 889 of the Federal Regulatory Commission ruled for wholesale power dealing. This stimulated such a growth that almost half of U.S. domestic power is sold in the wholesale electricity market, but operators are close to their stability limits. The recent and costly outages in western U.S. suggest that more transmission capacity is needed, but obtaining permits is difficult and an adequate rate of return on investment is uncertain. Some states are further complicating the issue by implementing retail access to provide consumers a choice among service providers. Concerns over transmission system integrity are founded in the fact that various infrastructures such as transportation, telecommunications, oil and gas, and financial systems, rely on the electric power infrastructure. If power failure occurs in one sector, it can readily propagate to another, multiplying the damage. The President's Council on Critical Infrastructure Protection has identified some policy objectives to ensure the development of effective technology responses to policy concerns to improve the reliability and security of the power system. Advanced control technologies such as High-voltage electronic FACTS (Flexible AC Transmission System), WAMS (Wide-Area Measurement System) and the use of high-temperature super-conducting materials created from ceramic oxides will be instrumental to upgrading the power delivery system which will be the key to U.S. economic growth. These advanced technologies could be in widespread use by 2005-2010. 1 fig

Focused ultrasound-facilitated brain drug delivery using optimized nanodroplets: vaporization efficiency dictates large molecular delivery

Science.gov (United States)

Wu, Shih-Ying; Fix, Samantha M.; Arena, Christopher B.; Chen, Cherry C.; Zheng, Wenlan; Olumolade, Oluyemi O.; Papadopoulou, Virginie; Novell, Anthony; Dayton, Paul A.; Konofagou, Elisa E.

2018-02-01

Focused ultrasound with nanodroplets could facilitate localized drug delivery after vaporization with potentially improved in vivo stability, drug payload, and minimal interference outside of the focal zone compared with microbubbles. While the feasibility of blood-brain barrier (BBB) opening using nanodroplets has been previously reported, characterization of the associated delivery has not been achieved. It was hypothesized that the outcome of drug delivery was associated with the droplet’s sensitivity to acoustic energy, and can be modulated with the boiling point of the liquid core. Therefore, in this study, octafluoropropane (OFP) and decafluorobutane (DFB) nanodroplets were used both in vitro for assessing their relative vaporization efficiency with high-speed microscopy, and in vivo for delivering molecules with a size relevant to proteins (40 kDa dextran) to the murine brain. It was found that at low pressures (300-450 kPa), OFP droplets vaporized into a greater number of microbubbles compared to DFB droplets at higher pressures (750-900 kPa) in the in vitro study. In the in vivo study, successful delivery was achieved with OFP droplets at 300 kPa and 450 kPa without evidence of cavitation damage using ¼ dosage, compared to DFB droplets at 900 kPa where histology indicated tissue damage due to inertial cavitation. In conclusion, the vaporization efficiency of nanodroplets positively impacted the amount of molecules delivered to the brain. The OFP droplets due to the higher vaporization efficiency served as better acoustic agents to deliver large molecules efficiently to the brain compared with the DFB droplets.

Oxidative stress in newborns by different modes of delivery

Czech Academy of Sciences Publication Activity Database

Veleminský Jr., M.; Ambrož, Antonín; Rössner ml., Pavel; Rössnerová, Andrea; Švecová, Vlasta; Milcová, Alena; Dostál, Miroslav; Pastorková, Anna; Pulkrabová, J.; Hajslová, J.; Solanský, Ivo; Hanzl, M.; Šrám, Radim

2016-01-01

Roč. 37, č. 6 (2016), s. 445-451 ISSN 0172-780X R&D Projects: GA ČR(CZ) GA13-13458S Institutional support: RVO:68378041 Keywords : vaginal delivery * Cesarean section * newborns Subject RIV: DN - Health Impact of the Environment Quality OBOR OECD: Public and environmental health Impact factor: 0.918, year: 2016

Improvement in transdermal drug delivery performance by graphite oxide/temperature-responsive hydrogel composites with micro heater

Energy Technology Data Exchange (ETDEWEB)

Yun, Jumi [Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University, Daejeon 305-764 (Korea, Republic of); Lee, Dae Hoon [Environment Research Division, Korea Institute of Machinery and Materials, 171 Jang-dong, Yusong-gu, Daejeon 305-343 (Korea, Republic of); Im, Ji Sun [Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University, Daejeon 305-764 (Korea, Republic of); Kim, Hyung-Il, E-mail: hikim@cnu.ac.kr [Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University, Daejeon 305-764 (Korea, Republic of)

2012-08-01

Transdermal drug delivery system (TDDS) was prepared with temperature-responsive hydrogel. The graphite was oxidized and incorporated into hydrogel matrix to improve the thermal response of hydrogel. The micro heater was fabricated to control the temperature precisely by adopting a joule heating method. The drug in hydrogel was delivered through a hairless mouse skin by controlling temperature. The efficiency of drug delivery was improved obviously by incorporation of graphite oxide due to the excellent thermal conductivity and the increased interfacial affinity between graphite oxide and hydrogel matrix. The fabricated micro heater was effective in controlling the temperature over lower critical solution temperature of hydrogel precisely with a small voltage less than 1 V. The cell viability test on graphite oxide composite hydrogel showed enough safety for using as a transdermal drug delivery patch. The performance of TDDS could be improved noticeably based on temperature-responsive hydrogel, thermally conductive graphite oxide, and efficient micro heater. - Graphical abstract: The high-performance transdermal drug delivery system could be prepared by combining temperature-responsive hydrogel, thermally conductive graphite oxide with improved interfacial affinity, and efficient micro heater fabricated by a joule heating method. Highlights: Black-Right-Pointing-Pointer High performance of transdermal drug delivery system with an easy control of voltage. Black-Right-Pointing-Pointer Improved thermal response of hydrogel by graphite oxide incorporation. Black-Right-Pointing-Pointer Efficient micro heater fabricated by a joule heating method.

Delivery presentations

Science.gov (United States)

Pregnancy - delivery presentation; Labor - delivery presentation; Occiput posterior; Occiput anterior; Brow presentation ... The mother can walk, rock, and try different delivery positions during labor to help encourage the baby ...

Methods and metrics challenges of delivery-system research

Directory of Open Access Journals (Sweden)

Alexander Jeffrey A

2012-03-01

Full Text Available Abstract Background Many delivery-system interventions are fundamentally about change in social systems (both planned and unplanned. This systems perspective raises a number of methodological challenges for studying the effects of delivery-system change--particularly for answering questions related to whether the change will work under different conditions and how the change is integrated (or not into the operating context of the delivery system. Methods The purpose of this paper is to describe the methodological and measurement challenges posed by five key issues in delivery-system research: (1 modeling intervention context; (2 measuring readiness for change; (3 assessing intervention fidelity and sustainability; (4 assessing complex, multicomponent interventions; and (5 incorporating time in delivery-system models to discuss recommendations for addressing these issues. For each issue, we provide recommendations for how research may be designed and implemented to overcome these challenges. Results and conclusions We suggest that a more refined understanding of the mechanisms underlying delivery-system interventions (treatment theory and the ways in which outcomes for different classes of individuals change over time are fundamental starting points for capturing the heterogeneity in samples of individuals exposed to delivery-system interventions. To support the research recommendations outlined in this paper and to advance understanding of the "why" and "how" questions of delivery-system change and their effects, funding agencies should consider supporting studies with larger organizational sample sizes; longer duration; and nontraditional, mixed-methods designs. A version of this paper was prepared under contract with the Agency for Healthcare Research and Quality (AHRQ, US Department of Health and Human Services for presentation and discussion at a meeting on "The Challenge and Promise of Delivery System Research," held in Sterling, VA, on

Maximizing Output Power of a Solar Panel via Combination of Sun Tracking and Maximum Power Point Tracking by Fuzzy Controllers

Directory of Open Access Journals (Sweden)

Mohsen Taherbaneh

2010-01-01

Full Text Available In applications with low-energy conversion efficiency, maximizing the output power improves the efficiency. The maximum output power of a solar panel depends on the environmental conditions and load profile. In this paper, a method based on simultaneous use of two fuzzy controllers is developed in order to maximize the generated output power of a solar panel in a photovoltaic system: fuzzy-based sun tracking and maximum power point tracking. The sun tracking is performed by changing the solar panel orientation in horizontal and vertical directions by two DC motors properly designed. A DC-DC converter is employed to track the solar panel maximum power point. In addition, the proposed system has the capability of the extraction of solar panel I-V curves. Experimental results present that the proposed fuzzy techniques result in increasing of power delivery from the solar panel, causing a reduction in size, weight, and cost of solar panels in photovoltaic systems.

Draft environmental statement related to steam-generator repair at Point Beach Nuclear Plant, Unit No. 1. Docket No. 50-266

International Nuclear Information System (INIS)

1983-07-01

The staff has considered the environmental impacts and economic costs of the proposed steam generator repair at the Point Beach Nuclear Plant Unit No. 1 along with reasonable alternatives to the proposed action. The staff has concluded that the proposed repair will not significantly affect the quality of the human environment and that there are no preferable alternatives to the proposed action. Furthermore, any impacts from the repair program are outweighed by its benefits

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Directory of Open Access Journals (Sweden)

Jahangirian H

2017-04-01

Full Text Available Hossein Jahangirian,1 Ensieh Ghasemian Lemraski,2 Thomas J Webster,1 Roshanak Rafiee-Moghaddam,3 Yadollah Abdollahi4 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Department of Chemistry, Faculty of Science, Ilam University, Ilam, Iran; 3School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Selangor, 4Department of Electrical Engineering, Faculty of Engineering, University of Malaysia, Kuala Lumpur, Malaysia Abstract: This review discusses the impact of green and environmentally safe chemistry on the field of nanotechnology-driven drug delivery in a new field termed “green nanomedicine”. Studies have shown that among many examples of green nanotechnology-driven drug delivery systems, those receiving the greatest amount of attention include nanometal particles, polymers, and biological materials. Furthermore, green nanodrug delivery systems based on environmentally safe chemical reactions or using natural biomaterials (such as plant extracts and microorganisms are now producing innovative materials revolutionizing the field. In this review, the use of green chemistry design, synthesis, and application principles and eco-friendly synthesis techniques with low side effects are discussed. The review ends with a description of key future efforts that must ensue for this field to continue to grow. Keywords: green chemistry, cancer, drug delivery, nanoparticle

Environmental Audits of High Voltage Objects from the View Point of Investors

International Nuclear Information System (INIS)

Marek Szuba, M.

2007-01-01

The localization of high voltage objects, e.g., overhead transmission lines, under the spatial planning and environmental protection regulations is discussed. The most important elements of the localization procedure concerning high voltage overhead lines are presented. One of the elements of this procedure is the assessment of the investment environmental impact. The environmental audit is an essential document, in which this impact is described. It seems that its scope specified in the Environmental Protection Act is not adjusted to the specificity of line investments. This gives rise to some problems in preparing environmental audits for overhead lines, e.g., possible influence of high voltage lines on the Natura 2000 area zones. Several other related problems are also highlighted in this paper. (author)

Split delivery vehicle routing problem with time windows: a case study

Science.gov (United States)

Latiffianti, E.; Siswanto, N.; Firmandani, R. A.

2018-04-01

This paper aims to implement an extension of VRP so called split delivery vehicle routing problem (SDVRP) with time windows in a case study involving pickups and deliveries of workers from several points of origin and several destinations. Each origin represents a bus stop and the destination represents either site or office location. An integer linear programming of the SDVRP problem is presented. The solution was generated using three stages of defining the starting points, assigning busses, and solving the SDVRP with time windows using an exact method. Although the overall computational time was relatively lengthy, the results indicated that the produced solution was better than the existing routing and scheduling that the firm used. The produced solution was also capable of reducing fuel cost by 9% that was obtained from shorter total distance travelled by the shuttle buses.

Characteristics of exogenous carbon monoxide deliveries

Directory of Open Access Journals (Sweden)

Hui-jun Hu

2016-01-01

Full Text Available Carbon monoxide (CO has long been considered an environmental pollutant and a poison. Exogenous exposure to amounts of CO beyond the physiologic level of the body can result in a protective or adaptive response. However, as a gasotransmitter, endogenous CO is important for multiple physiologic functions. To date, at least seven distinct methods of delivering CO have been utilized in animal and clinical studies. In this mini-review, we summarize the exogenous CO delivery methods and compare their advantages and disadvantages.

Business administration of PET facilities. A cost analysis of three facilities utilizing delivery FDG

International Nuclear Information System (INIS)

Mitsutake, Naohiro; Oku, Shinya; Fujii, Ryo; Furui, Yuji; Yasunaga, Hideo

2008-01-01

PET (positron emission tomography) has been proved to be a powerful imaging tool in clinical oncology. The number of PET facilities in Japan has remarkably increased over the last decade. Furthermore, the approval of delivery fluorodeoxyglucose (FDG) in 2005 resulted in a tremendous expansion of the PET institutions without a cyclotron facility. The aim of this study was to conduct a cost analysis of PET institutions that utilized delivery FDG. Three PET facilities using delivery FDG were investigated about the costs for PET service. Fixed costs included depreciation costs for construction and medical equipments such as positron camera. Variable costs consisted of costs for medical materials including delivery FDG. The break-even point was analyzed in each of three institutions. In the three hospitals (A, B and C), the annual number of PET scan was 1,591, 1,637 and 914, while cost per scan was accounted as 110,262 yen, 111,091 yen, and 134,192 yen, respectively. The break-even point was calculated to be 2,583, 2,679 and 2,081, respectively. PET facilities utilizing delivery FDG seemed to have difficulty in business administration. Such a situation suggests the possibility that the current supply of PET facilities might exceed actual demand for the service. The efficiency of resource allocation should be taken into consideration in the future health service researches on PET. (author)

Transdermal drug delivery

Science.gov (United States)

Prausnitz, Mark R.; Langer, Robert

2009-01-01

Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs. Second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in clinical products; the ability of iontophoresis to control delivery rates in real time provides added functionality. Third-generation delivery systems target their effects to skin’s barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound. Microneedles and thermal ablation are currently progressing through clinical trials for delivery of macromolecules and vaccines, such as insulin, parathyroid hormone and influenza vaccine. Using these novel second- and third-generation enhancement strategies, transdermal delivery is poised to significantly increase impact on medicine. PMID:18997767

Environmental assessment in The Netherlands: Effectively governing environmental protection? A discourse analysis

Energy Technology Data Exchange (ETDEWEB)

Runhaar, Hens, E-mail: h.a.c.runhaar@uu.nl [Utrecht University, Copernicus Institute of Sustainable Development, P.O. Box 80,115, 3508 TC Utrecht (Netherlands); Laerhoven, Frank van, E-mail: vanLaerhoven@uu.nl [Utrecht University, Copernicus Institute of Sustainable Development, P.O. Box 80,115, 3508 TC Utrecht (Netherlands); Driessen, Peter, E-mail: p.driessen@uu.nl [Utrecht University, Copernicus Institute of Sustainable Development, P.O. Box 80,115, 3508 TC Utrecht (Netherlands); Arts, Jos, E-mail: e.j.m.m.arts@rug.nl [University of Groningen, Faculty of Planning, P.O. Box 800, 9700 AV Groningen (Netherlands)

2013-02-15

less consensual political cultures we may expect more extreme discourses on EA, the consequences of which are reflected upon in this paper. - Highlights: Black-Right-Pointing-Pointer The effectiveness of environmental assessment (EA) depends in part on meanings associated with EA (i.e., discourse). Black-Right-Pointing-Pointer Our results suggest that the general discourse in The Netherlands is that EA is a legal requirement, nothing more. Black-Right-Pointing-Pointer This discourse makes EA effective in protecting the environment, but not in the optimisation of environmental values. Black-Right-Pointing-Pointer EA has a limited contribution to the development of policy alternatives or innovative solutions to environmental problems. Black-Right-Pointing-Pointer There is a high consensus among EA professionals, providing a common ground for working with EA.

Natural and synthetic biomaterials for controlled drug delivery.

Science.gov (United States)

Kim, Jang Kyoung; Kim, Hyung Jin; Chung, Jee-Young; Lee, Jong-Hwan; Young, Seok-Beom; Kim, Yong-Hee

2014-01-01

A wide variety of delivery systems have been developed and many products based on the drug delivery technology are commercially available. The development of controlled-release technologies accelerated new dosage form design by altering pharmacokinetic and pharmacodynamics profiles of given drugs, resulting in improved efficacy and safety. Various natural or synthetic polymers have been applied to make matrix, reservoir or implant forms due to the characteristics of polymers, especially ease of control for modifications of biocompatibility, biodegradation, porosity, charge, mechanical strength and hydrophobicity/hydrophilicity. Hydrogel is a hydrophilic, polymeric network capable of imbibing large amount of water and biological fluids. This review article introduces various applications of natural and synthetic polymer-based hydrogels from pharmaceutical, biomedical and bioengineering points of view.

Random Linear Network Coding for 5G Mobile Video Delivery

Directory of Open Access Journals (Sweden)

Dejan Vukobratovic

2018-03-01

Full Text Available An exponential increase in mobile video delivery will continue with the demand for higher resolution, multi-view and large-scale multicast video services. Novel fifth generation (5G 3GPP New Radio (NR standard will bring a number of new opportunities for optimizing video delivery across both 5G core and radio access networks. One of the promising approaches for video quality adaptation, throughput enhancement and erasure protection is the use of packet-level random linear network coding (RLNC. In this review paper, we discuss the integration of RLNC into the 5G NR standard, building upon the ideas and opportunities identified in 4G LTE. We explicitly identify and discuss in detail novel 5G NR features that provide support for RLNC-based video delivery in 5G, thus pointing out to the promising avenues for future research.

Assisted Vaginal Delivery

Science.gov (United States)

... Education & Events Advocacy For Patients About ACOG Assisted Vaginal Delivery Home For Patients Search FAQs Assisted Vaginal ... Vaginal Delivery FAQ192, February 2016 PDF Format Assisted Vaginal Delivery Labor, Delivery, and Postpartum Care What is ...

Dendrimers as Carriers for siRNA Delivery and Gene Silencing: A Review

Directory of Open Access Journals (Sweden)

Jiangyu Wu

2013-01-01

Full Text Available RNA interference (RNAi was first literaturally reported in 1998 and has become rapidly a promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small interfering RNAs (siRNA are used to specifically downregulate the expression of the targeted gene, known as the term “gene silencing.” One key point for successful gene silencing is to employ a safe and efficient siRNA delivery system. In this context, dendrimers are emerging as potential nonviral vectors to deliver siRNA for RNAi purpose. Dendrimers have attracted intense interest since their emanating research in the 1980s and are extensively studied as efficient DNA delivery vectors in gene transfer applications, due to their unique features based on the well-defined and multivalent structures. Knowing that DNA and RNA possess a similar structure in terms of nucleic acid framework and the electronegative nature, one can also use the excellent DNA delivery properties of dendrimers to develop effective siRNA delivery systems. In this review, the development of dendrimer-based siRNA delivery vectors is summarized, focusing on the vector features (siRNA delivery efficiency, cytotoxicity, etc. of different types of dendrimers and the related investigations on structure-activity relationship to promote safe and efficient siRNA delivery system.

Dendrimers as Carriers for siRNA Delivery and Gene Silencing: A Review

Science.gov (United States)

Huang, Weizhe; He, Ziying

2013-01-01

RNA interference (RNAi) was first literaturally reported in 1998 and has become rapidly a promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small interfering RNAs (siRNA) are used to specifically downregulate the expression of the targeted gene, known as the term “gene silencing.” One key point for successful gene silencing is to employ a safe and efficient siRNA delivery system. In this context, dendrimers are emerging as potential nonviral vectors to deliver siRNA for RNAi purpose. Dendrimers have attracted intense interest since their emanating research in the 1980s and are extensively studied as efficient DNA delivery vectors in gene transfer applications, due to their unique features based on the well-defined and multivalent structures. Knowing that DNA and RNA possess a similar structure in terms of nucleic acid framework and the electronegative nature, one can also use the excellent DNA delivery properties of dendrimers to develop effective siRNA delivery systems. In this review, the development of dendrimer-based siRNA delivery vectors is summarized, focusing on the vector features (siRNA delivery efficiency, cytotoxicity, etc.) of different types of dendrimers and the related investigations on structure-activity relationship to promote safe and efficient siRNA delivery system. PMID:24288498

Bubble point measurement and high pressure distillation column design for the environmentally benign separation of zirconium from hafnium for nuclear power reactor

International Nuclear Information System (INIS)

Minh, Le Quang; Kim, Gyeongmin; Lee, Moonyong; Park, Jongki

2015-01-01

We examined the feasible separation of ZrCl 4 and HfCl 4 through high pressure distillation as environmentally benign separation for structural material of nuclear power reactor. The bubble point pressures of ZrCl 4 and HfCl 4 mixtures were determined experimentally by using an invariable volume equilibrium cell at high pressure and temperature condition range of 2.3-5..6MPa and 440-490 .deg. C. The experimental bubble point pressure data were correlated with Peng-Robinson equation of state with a good agreement. Based on the vapor-liquid equilibrium properties evaluated from the experimental data, the feasibility of high pressure distillation process for the separation of ZrCl 4 and HfCl 4 was investigated with its main design condition through rigorous simulation using a commercial process simulator, ASPEN Hysys. An enhanced distillation configuration was also proposed to improve energy efficiency in the distillation process. The result showed that a heat-pump assisted distillation with a partial bottom flash could be a promising option for commercial separation of ZrCl 4 and HfCl 4 by taking into account of both energy and environmental advantages

Application of mathematical modeling in sustained release delivery systems.

Science.gov (United States)

Grassi, Mario; Grassi, Gabriele

2014-08-01

This review, presenting as starting point the concept of the mathematical modeling, is aimed at the physical and mathematical description of the most important mechanisms regulating drug delivery from matrix systems. The precise knowledge of the delivery mechanisms allows us to set up powerful mathematical models which, in turn, are essential for the design and optimization of appropriate drug delivery systems. The fundamental mechanisms for drug delivery from matrices are represented by drug diffusion, matrix swelling, matrix erosion, drug dissolution with possible recrystallization (e.g., as in the case of amorphous and nanocrystalline drugs), initial drug distribution inside the matrix, matrix geometry, matrix size distribution (in the case of spherical matrices of different diameter) and osmotic pressure. Depending on matrix characteristics, the above-reported variables may play a different role in drug delivery; thus the mathematical model needs to be built solely on the most relevant mechanisms of the particular matrix considered. Despite the somewhat diffident behavior of the industrial world, in the light of the most recent findings, we believe that mathematical modeling may have a tremendous potential impact in the pharmaceutical field. We do believe that mathematical modeling will be more and more important in the future especially in the light of the rapid advent of personalized medicine, a novel therapeutic approach intended to treat each single patient instead of the 'average' patient.

Energy use and life cycle greenhouse gas emissions of drones for commercial package delivery.

Science.gov (United States)

Stolaroff, Joshuah K; Samaras, Constantine; O'Neill, Emma R; Lubers, Alia; Mitchell, Alexandra S; Ceperley, Daniel

2018-02-13

The use of automated, unmanned aerial vehicles (drones) to deliver commercial packages is poised to become a new industry, significantly shifting energy use in the freight sector. Here we find the current practical range of multi-copters to be about 4 km with current battery technology, requiring a new network of urban warehouses or waystations as support. We show that, although drones consume less energy per package-km than delivery trucks, the additional warehouse energy required and the longer distances traveled by drones per package greatly increase the life-cycle impacts. Still, in most cases examined, the impacts of package delivery by small drone are lower than ground-based delivery. Results suggest that, if carefully deployed, drone-based delivery could reduce greenhouse gas emissions and energy use in the freight sector. To realize the environmental benefits of drone delivery, regulators and firms should focus on minimizing extra warehousing and limiting the size of drones.

Self-nanoemulsifying drug delivery systems for oral insulin delivery

DEFF Research Database (Denmark)

Li, Ping; Tan, Angel; Prestidge, Clive A

2014-01-01

This study aims at evaluating the combination of self-nanoemulsifying drug delivery systems (SNEDDS) and enteric-coated capsules as a potential delivery strategy for oral delivery of insulin. The SNEDDS preconcentrates, loaded with insulin-phospholipid complex at different levels (0, 2.5 and 10% w...

Critical gases for critical issues: CO2 technologies for oral drug delivery.

Science.gov (United States)

Danan, Hana; Esposito, Pierandrea

2014-02-01

In recent years, CO2-based technologies have gained considerable interest in the pharmaceutical industry for their potential applications in drug formulation and drug delivery. The exploitation of peculiar properties of gases under supercritical conditions has been studied in the last 20 years with mixed results. Promising drug-delivery technologies, based on supercritical CO2, have mostly failed when facing challenges of industrial scaleability and economical viability. Nevertheless, a 'second generation' of processes, based on CO2 around and below critical point has been developed, possibly offering technology-based solutions to some of the current issues of pharmaceutical development. In this review, we highlight the most recent advancements in this field, with a particular focus on the potential of CO2-based technologies in addressing critical issues in oral delivery, and briefly discuss the future perspectives of dense CO2-assisted processes as enabling technologies in drug delivery.

Transdermal drug delivery

OpenAIRE

Prausnitz, Mark R.; Langer, Robert

2008-01-01

Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs. Second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in clinical products; the ability ...

Environmental Assessment: Gulf Power Company Military Point Transmission Line Project

Science.gov (United States)

2014-05-12

1500.4. 1.4. 1 Geology No geological hazards, seismic risks, or unstable slopes occur in the vicinity of Military Point on Tyndall AFB. Therefore, the...with sand grout to fill any voids within the casing and provide thermal insulation for the electric cable. Lengths greater than 3,000 feet would be...devices designed to either insulate or isolate potential contact points have. been recommended to minimize the risk of eagle electrocution, which are

Environmental restoration using horizontal wells

International Nuclear Information System (INIS)

Looney, B.B.; Kaback, D.S.; Hazen, T.C.; Corey, J.C.

1992-01-01

This paper reports that under sponsorship from the U.S. Department of Energy, technical personnel from the Savannah River Laboratory and other DOE laboratories, universities and private industry have completed a full scale demonstration of environmental remediation using horizontal wells. The test successfully removed approximately 7250 kg of contaminants. A large amount of characterization and monitoring data was collected to aid in interpretation of the test and to provide the information needed for future environmental restorations that employ directionally drilled wells as extraction or delivery systems

Web-Based Learning Enhancements: Video Lectures through Voice-Over PowerPoint in a Majors-Level Biology Course

Science.gov (United States)

Lents, Nathan H.; Cifuentes, Oscar E.

2009-01-01

This study is an experimental introduction of web-based lecture delivery into a majors-level introductory biology course. Web-based delivery, achieved through the use of prerecorded Voice-Over PowerPoint video lectures, was introduced on a limited basis to an experimental section while a control group, with the same instructor, received standard…

Novel nanocarriers for topical drug delivery: investigating delivery efficiency and distribution in skin using two-photon microscopy

Science.gov (United States)

Kirejev, Vladimir; Guldbrand, Stina; Bauer, Brigitte; Smedh, Maria; Ericson, Marica B.

2011-03-01

The complex structure of skin represents an effective barrier against external environmental factors, as for example, different chemical and biochemical compounds, yeast, bacterial and viral infections. However, this impermeability prevents efficient transdermal drug delivery which limits the number of drugs that are able to penetrate the skin efficiently. Current trends in drug application through skin focus on the design and use of nanocarriers for transport of active compounds. The transport systems applied so far have several drawbacks, as they often have low payload, high toxicity, a limited variability of inclusion molecules, or long degradation times. The aim of these current studies is to investigate novel topical drug delivery systems, e.g. nanocarriers based on cyclic oligosaccharides - cyclodextrins (CD) or iron (III)-based metal-organic frameworks (MOF). Earlier studies on cell cultures imply that these drug nanocarriers show promising characteristics compared to other drug delivery systems. In our studies, we use two-photon microscopy to investigate the ability of the nanocarriers to deliver compounds through ex-vivo skin samples. Using near infrared light for excitation in the so called optical window of skin allows deep-tissue visualization of drug distribution and localization. In addition, it is possible to employ two-photon based fluorescence correlation spectroscopy for quantitative analysis of drug distribution and concentrations in different cell layers.

Quantitative dosimetric verification of an IMRT planning and delivery system

International Nuclear Information System (INIS)

Low, D.A.; Mutic, S.; Dempsey, J.F.; Gerber, R.L.; Bosch, W.R.; Perez, C.A.; Purdy, J.A.

1998-01-01

Background and purpose: The accuracy of dose calculation and delivery of a commercial serial tomotherapy treatment planning and delivery system (Peacock, NOMOS Corporation) was experimentally determined. Materials and methods: External beam fluence distributions were optimized and delivered to test treatment plan target volumes, including three with cylindrical targets with diameters ranging from 2.0 to 6.2 cm and lengths of 0.9 through 4.8 cm, one using three cylindrical targets and two using C-shaped targets surrounding a critical structure, each with different dose distribution optimization criteria. Computer overlays of film-measured and calculated planar dose distributions were used to assess the dose calculation and delivery spatial accuracy. A 0.125 cm 3 ionization chamber was used to conduct absolute point dosimetry verification. Thermoluminescent dosimetry chips, a small-volume ionization chamber and radiochromic film were used as independent checks of the ion chamber measurements. Results: Spatial localization accuracy was found to be better than ±2.0 mm in the transverse axes (with one exception of 3.0 mm) and ±1.5 mm in the longitudinal axis. Dosimetric verification using single slice delivery versions of the plans showed that the relative dose distribution was accurate to ±2% within and outside the target volumes (in high dose and low dose gradient regions) with a mean and standard deviation for all points of -0.05% and 1.1%, respectively. The absolute dose per monitor unit was found to vary by ±3.5% of the mean value due to the lack of consideration for leakage radiation and the limited scattered radiation integration in the dose calculation algorithm. To deliver the prescribed dose, adjustment of the monitor units by the measured ratio would be required. Conclusions: The treatment planning and delivery system offered suitably accurate spatial registration and dose delivery of serial tomotherapy generated dose distributions. The quantitative dose

Economic-environmental modeling of point source pollution in Jefferson County, Alabama, USA.

Science.gov (United States)

Kebede, Ellene; Schreiner, Dean F; Huluka, Gobena

2002-05-01

This paper uses an integrated economic-environmental model to assess the point source pollution from major industries in Jefferson County, Northern Alabama. Industrial expansion generates employment, income, and tax revenue for the public sector; however, it is also often associated with the discharge of chemical pollutants. Jefferson County is one of the largest industrial counties in Alabama that experienced smog warnings and ambient ozone concentration, 1996-1999. Past studies of chemical discharge from industries have used models to assess the pollution impact of individual plants. This study, however, uses an extended Input-Output (I-O) economic model with pollution emission coefficients to assess direct and indirect pollutant emission for several major industries in Jefferson County. The major findings of the study are: (a) the principal emission by the selected industries are volatile organic compounds (VOC) and these contribute to the ambient ozone concentration; (b) the direct and indirect emissions are significantly higher than the direct emission by some industries, indicating that an isolated analysis will underestimate the emission by an industry; (c) while low emission coefficient industries may suggest industry choice they may also emit the most hazardous chemicals. This study is limited by the assumptions made, and the data availability, however it provides a useful analytical tool for direct and cumulative emission estimation and generates insights on the complexity in choice of industries.

Development of wood fuel delivery logistics; Puupolttoaineiden hankintalogistiikan kehittaeminen

Energy Technology Data Exchange (ETDEWEB)

Laitinen, H

1997-12-31

The main aim of the project is to model the energy wood business and total logistics in a certain large region. First, wood utilisation locations inside this area are examined; the most important ones are the wood processing factories, and the heating- and power plants. After that, wood potentials in the forests of the area are evaluated in sub-areas suitable in size and sufficiently detailed for further evaluations. For that purpose, the most valuable source data are forest management plans, up to ten years forward, on which basis the wood fuel potentials can be evaluated following sustainable development. In Finland there are extensive and detailed data bases storing forest information and it is possible to collect necessary data for a data base applicable to our calculations. In logistical sense it is important to know, by which delivery chains the economically best and desired results are achieved. The software prototype based on data base is modelled and developed at VTT Energy, for facilitating these planning activities. The starting point of the planning system in delivery logistics is the implementation of an easy tool for versatile planning so that with this tool model different delivery chains can be flexiblyed, create usage scenarios, make alternative examinations, and calculate impacts of different factors on energy wood amounts yielded and delivery costs. With planning system in delivery logistics we calculate production costs and amounts delivered to different utilisation locations. The system offers tools for definitions of utilisation locations, calculation parameters, and delivery chains

Development of wood fuel delivery logistics; Puupolttoaineiden hankintalogistiikan kehittaeminen

Energy Technology Data Exchange (ETDEWEB)

Laitinen, H.

1996-12-31

The main aim of the project is to model the energy wood business and total logistics in a certain large region. First, wood utilisation locations inside this area are examined; the most important ones are the wood processing factories, and the heating- and power plants. After that, wood potentials in the forests of the area are evaluated in sub-areas suitable in size and sufficiently detailed for further evaluations. For that purpose, the most valuable source data are forest management plans, up to ten years forward, on which basis the wood fuel potentials can be evaluated following sustainable development. In Finland there are extensive and detailed data bases storing forest information and it is possible to collect necessary data for a data base applicable to our calculations. In logistical sense it is important to know, by which delivery chains the economically best and desired results are achieved. The software prototype based on data base is modelled and developed at VTT Energy, for facilitating these planning activities. The starting point of the planning system in delivery logistics is the implementation of an easy tool for versatile planning so that with this tool model different delivery chains can be flexiblyed, create usage scenarios, make alternative examinations, and calculate impacts of different factors on energy wood amounts yielded and delivery costs. With planning system in delivery logistics we calculate production costs and amounts delivered to different utilisation locations. The system offers tools for definitions of utilisation locations, calculation parameters, and delivery chains

Requirements for the retrofitting an extension of the maximum voltage power grid from the point of view of environmental protection and cultivated landscape work

International Nuclear Information System (INIS)

2013-01-01

The project on the requirements for the retrofitting an extension of the maximum voltage power grid from the point of view of environmental protection and cultivated landscape work includes contributions on the following topics: the development of the European transmission grid, the grid extension law, restrictions for the power grid and their infrastructure, requirements for the regulations concerning the realization of the transnational grid extension, inclusion of the public - public acceptance - communication, requirements concerning the environmental compensation law, overhead line - underground cable - health hazards, ecological effects of overhead lines and underground cables, infrastructural projects, power supply in the future, structural relief by photovoltaics.

Oahu Sewer Manhole Points, Oahu County HI, 2016, Honolulu GIS

Data.gov (United States)

U.S. Environmental Protection Agency — Point features representing sewer manholes as maintained by Honolulu ENV Department of Environmental Services. This inventory of sewer manholes used by tracking,...

Assessing delivery practices of mothers over time and over space in Uganda, 2003–2012

Directory of Open Access Journals (Sweden)

Daniel A. Sprague

2016-06-01

Full Text Available Abstract Background It is well known that safe delivery in a health facility reduces the risks of maternal and infant mortality resulting from perinatal complications. What is less understood are the factors associated with safe delivery practices. We investigate factors influencing health facility delivery practices while adjusting for multiple other factors simultaneously, spatial heterogeneity, and trends over time. Methods We fitted a logistic regression model to Lot Quality Assurance Sampling (LQAS data from Uganda in a framework that considered individual-level covariates, geographical features, and variations over five time points. We accounted for all two-covariate interactions and all three-covariate interactions for which two of the covariates already had a significant interaction, were able to quantify uncertainty in outputs using computationally intensive cluster bootstrap methods, and displayed outputs using a geographical information system. Finally, we investigated what information could be predicted about districts at future time-points, before the next LQAS survey is carried out. To do this, we applied the model to project a confidence interval for the district level coverage of health facility delivery at future time points, by using the lower and upper end values of known demographics to construct a confidence range for the prediction and define priority groups. Results We show that ease of access, maternal age and education are strongly associated with delivery in a health facility; after accounting for this, there remains a significant trend towards greater uptake over time. We use this model together with known demographics to formulate a nascent early warning system that identifies candidate districts expected to have low prevalence of facility-based delivery in the immediate future. Conclusions Our results support the hypothesis that increased development, particularly related to education and access to health facilities

Service Delivery and Related Issues at the Trace Research and Development Center.

Science.gov (United States)

Smith, R. O.

The environmental context of the Trace Center is first briefly described as background for a more detailed description of the center's service delivery activities in the field of rehabilitation/education technology. Trace serves four major functions in rehabilitation/education technology. As a nationally funded rehabilitation engineering center,…

Heat: A Highly Efficient Skin Enhancer for Transdermal Drug Delivery.

Science.gov (United States)

Szunerits, Sabine; Boukherroub, Rabah

2018-01-01

Advances in materials science and bionanotechnology have allowed the refinements of current drug delivery systems, expected to facilitate the development of personalized medicine. While dermatological topical pharmaceutical formulations such as foams, creams, lotions, gels, etc., have been proposed for decades, these systems target mainly skin-based diseases. To treat systemic medical conditions as well as localized problems such as joint or muscle concerns, transdermal delivery systems (TDDSs), which use the skin as the main route of drug delivery, are very appealing. Over the years, these systems have shown to offer important advantages over oral as well as intravenous drug delivery routes. Besides being non-invasive and painless, TDDSs are able to deliver drugs with a short-half-life time more easily and are well adapted to eliminate frequent administrations to maintain constant drug delivery. The possibility of self-administration of a predetermined drug dose at defined time intervals makes it also the most convenient personalized point-of-care approach. The transdermal market still remains limited to a narrow range of drugs. While small and lipophilic drugs have been successfully delivered using TDDSs, this approach fails to deliver therapeutic macromolecules due to size-limited transport across the stratum corneum , the outermost layer of the epidermis. The low permeability of the stratum corneum to water-soluble drugs as well as macromolecules poses important challenges to transdermal administration. To widen the scope of drugs for transdermal delivery, new procedures to enhance skin permeation to hydrophilic drugs and macromolecules are under development. Next to iontophoresis and microneedle-based concepts, thermal-based approaches have shown great promise to enhance transdermal drug delivery of different therapeutics. In this inaugural article for the section "Frontiers in Bioengineering and Biotechnology," the advances in this field and the handful of

Carrier-Based Drug Delivery System for Treatment of Acne

Science.gov (United States)

Vyas, Amber; Kumar Sonker, Avinesh

2014-01-01

Approximately 95% of the population suffers at some point in their lifetime from acne vulgaris. Acne is a multifactorial disease of the pilosebaceous unit. This inflammatory skin disorder is most common in adolescents but also affects neonates, prepubescent children, and adults. Topical conventional systems are associated with various side effects. Novel drug delivery systems have been used to reduce the side effect of drugs commonly used in the topical treatment of acne. Topical treatment of acne with active pharmaceutical ingredients (API) makes direct contact with the target site before entering the systemic circulation which reduces the systemic side effect of the parenteral or oral administration of drug. The objective of the present review is to discuss the conventional delivery systems available for acne, their drawbacks, and limitations. The advantages, disadvantages, and outcome of using various carrier-based delivery systems like liposomes, niosomes, solid lipid nanoparticles, and so forth, are explained. This paper emphasizes approaches to overcome the drawbacks and limitations associated with the conventional system and the advances and application that are poised to further enhance the efficacy of topical acne formulations, offering the possibility of simplified dosing regimen that may improve treatment outcomes using novel delivery system. PMID:24688376

Pharmacokinetics of the transdermal delivery of benfotiamine.

Science.gov (United States)

Zhu, Zhen; Varadi, Gyula; Carter, Stephen G

2016-04-01

Accumulation of advanced glycation endpoints is a trigger to the development of diabetic peripheral neuropathy, which is a common complication of diabetes. Oral administration of benfotiamine (BFT) has shown some preclinical and clinical promise as a treatment for diabetic peripheral neuropathy. The purpose of this study was to evaluate the method of transdermal delivery of BFT as a possible, viable route of administration for the treatment of diabetic peripheral neuropathy. A single application of 10 mg of BFT was given to guinea pigs topically. The levels of thiamine (T), thiamine monophosphate, thiamine diphosphate, S-benzoylthiamine and BFT were measured in the blood, skin and muscle at different time points within 24 h. At the 24-h time point, following the single BFT dose, the T level was increased 10× in the blood, more than 7× in the skin and almost 4× in the muscle compared to the untreated animals. The total T content (total) was increased 7× in the blood, 17× in the skin and 3× in the muscle compared to the untreated animals. This strong increase in the tissue levels of T and the associated metabolic derivatives levels found in the blood and local tissues following a single dose indicate that topically applied BFT may be a viable and advantageous delivery method for the treatment of diabetic peripheral neuropathy.

Superfund Removal Site Points, Region 9, 2012, US EPA Region 9

Data.gov (United States)

U.S. Environmental Protection Agency — Point geospatial dataset representing locations of CERCLA (Superfund) Removal sites. CERCLA (Comprehensive Environmental Response, Compensation, and Liability Act)...

Co-ordination of federal and provincial environmental assessment processes for the Point Lepreau Generating Station Solid Radioactive Waste Management Facility modifications

International Nuclear Information System (INIS)

Hickman, C.; Thompson, P.D.; Barnes, J.

2006-01-01

Modification of the Solid Radioactive Waste Management Facility at Point Lepreau Generating Station is required to accommodate waste generated during and after an 18-month maintenance outage during which the station would be Refurbished. The modification of the facility triggered both federal and provincial environmental assessment requirements, and these assessments were conducted in a 'coordinated' and cooperative fashion. In this project, the coordinated approach worked well, and provided some significant advantages to the proponent, the public and the regulators. However, there are opportunities for further improvement in future projects, and this paper explores the advantages and disadvantages of this 'co-ordinated' approach. As part of this exploration, there is a discussion of administrative and regulatory changes that the province is considering for the environmental assessment process, and a discussion of the need for a formal 'harmonization' agreement. (author)

Leveraging socially networked mobile ICT platforms for the last-mile delivery problem.

Science.gov (United States)

Suh, Kyo; Smith, Timothy; Linhoff, Michelle

2012-09-04

Increasing numbers of people are managing their social networks on mobile information and communication technology (ICT) platforms. This study materializes these social relationships by leveraging spatial and networked information for sharing excess capacity to reduce the environmental impacts associated with "last-mile" package delivery systems from online purchases, particularly in low population density settings. Alternative package pickup location systems (PLS), such as a kiosk on a public transit platform or in a grocery store, have been suggested as effective strategies for reducing package travel miles and greenhouse gas emissions, compared to current door-to-door delivery models (CDS). However, our results suggest that a pickup location delivery system operating in a suburban setting may actually increase travel miles and emissions. Only once a social network is employed to assist in package pickup (SPLS) are significant reductions in the last-mile delivery distance and carbon emissions observed across both urban and suburban settings. Implications for logistics management's decades-long focus on improving efficiencies of dedicated distribution systems through specialization, as well as for public policy targeting carbon emissions of the transport sector are discussed.

Site environmental programs

Energy Technology Data Exchange (ETDEWEB)

Schmidt, J.W.; Hanf, R.W.

1995-06-01

This section of the 1994 Hanford Site Environmental Report summarizes the site environmental programs. Effluent monitoring and environmental surveillance programs monitor for impacts from operations in several areas. The first area consists of the point of possible release into the environment. The second area consists of possible contamination adjacent to DOE facilities, and the third area is the general environment both on and off the site.

Site environmental programs

International Nuclear Information System (INIS)

Schmidt, J.W.; Hanf, R.W.

1995-01-01

This section of the 1994 Hanford Site Environmental Report summarizes the site environmental programs. Effluent monitoring and environmental surveillance programs monitor for impacts from operations in several areas. The first area consists of the point of possible release into the environment. The second area consists of possible contamination adjacent to DOE facilities, and the third area is the general environment both on and off the site

Manual rotation to decrease operative delivery in posterior or transverse positions.

Science.gov (United States)

Le Ray, Camille; Deneux-Tharaux, Catherine; Khireddine, Imane; Dreyfus, Michel; Vardon, Delphine; Goffinet, François

2013-09-01

To assess the effect of a policy of manual rotation on the mode of delivery of fetuses in posterior or transverse positions at full dilatation. This was a prospective study to compare two policies of management for posterior and transverse positions in two different hospitals (Hospital 1: no manual rotation and Hospital 2: manual rotation). We used univariable and multivariable analyses to study the association between the management policy for posterior and transverse positions at full dilatation in these hospitals and maternal and neonatal outcomes. The principal end point was operative delivery (ie, cesarean or instrumental vaginal delivery). All factors associated with the risk of operative delivery in the univariable analysis (Pmanual rotation was independently associated with a reduction in operative deliveries. The rate of posterior or transverse positions at full dilatation was 15.9% (n=111) in Hospital 1 and 15.3% (n=220) in Hospital 2 (P=.75). Of the 172 attempts of manual rotation in Hospital 2, 155 (90.1%) were successful. The rate of operative delivery was significantly lower in Hospital 2, which performed manual rotations (23.2% compared with 38.7% in Hospital 1, adjusted odds ratio [OR] 0.52, 95% confidence interval [CI] 0.28-0.95). After multivariable analysis, manual rotation remained significantly associated with a reduction in the risk of operative delivery (adjusted OR 0.45, 95% CI 0.25-0.85). Five-minute Apgar score and arterial pH at birth were similar in the two hospitals. For fetuses in posterior or transverse positions at full dilatation, a strategy of manual rotation is associated with a reduction in the rate of operative delivery. III.

Environmental impact statements: new legal technique for environmental protection

Energy Technology Data Exchange (ETDEWEB)

Baldwin, M F

1975-02-01

The National Environmental Policy Act (NEPA) has required Federal agencies to re-examine all their programs affecting the environment, to consider alternative policies, to coordinate their actions with other agencies, and to disclose their environmental analyses to the public. In short, it has attempted to change decision processes markedly, in order to respond to wide-spread public concern about a deteriorating natural and human environment. The mandates of the policy are listed, but knowing that these were not sufficient to change existing agency practices, Congress established what has been called an ''action-forcing mechanism.'' Each federal agency must ''include in every recommendation or report on proposals for legislation and other major federal actions significantly affecting the quality of the human environment, a detailed statement by the responsible official.'' This statement must cover the following five points as specified in Section 102(2)(c): the environmental impact of the proposed action; any adverse environmental effects which cannot be avoided should the proposal be implemented; alternatives to the proposed action; the relationship between local and short-term uses of man's environment and the maintenance and enhancement of long-term productivity, and any irreversible and irretrievable commitments of resources which would be involved in the proposed action should it be implemented. Section 102 has been considered the heart of the National Environmental Policy Act. The specific five-point environmental report--known as an environmental impact statement--is the visible evidence of an agency's compliance with the environmental policy articulated by Congress. (MCW)

Reinventing Emergency Department Flow via Healthcare Delivery Science.

Science.gov (United States)

DeFlitch, Christopher; Geeting, Glenn; Paz, Harold L

2015-01-01

Healthcare system flow resulting in emergency departments (EDs) crowding is a quality and access problem. This case study examines an overcrowded academic health center ED with increasing patient volumes and limited physical space for expansion. ED capacity and efficiency improved via engineering principles application, addressing patient and staffing flows, and reinventing the delivery model. Using operational data and staff input, patient and staff flow models were created, identifying bottlenecks (points of inefficiency). A new flow model of emergency care delivery, physician-directed queuing, was developed. Expanding upon physicians in triage, providers passively evaluate all patients upon arrival, actively manage patients requiring fewer resources, and direct patients requiring complex resources to further evaluation in ED areas. Sustained over time, ED efficiency improved as measured by near elimination of "left without being seen" patients and waiting times with improvement in door to doctor, patient satisfaction, and total length of stay. All improvements were in the setting on increased patient volume and no increase in physician staffing. Our experience suggests that practical application of healthcare delivery science can be used to improve ED efficiency. © The Author(s) 2015.

Simulation based medical education; teaching normal delivery on intermediate fidelity simulator to medical students.

Science.gov (United States)

Shah, Nighat; Baig, Lubna; Shah, Nusrat; Hussain, Riffat; Aly, Syed Moyn

2017-10-01

To assess the effectiveness of medium fidelity simulator in teaching normal vaginal delivery to medical students. The quasi-experimental study was conducted at the professional development centre of the Jinnah Sindh Medical University, Karachi, from June to December 2015, and comprised medical students. Third-year medical students were included. They were divided into two groups. Group A was taught normal delivery through traditional PowerPoint and group B through simulator. The instruments used for assessing knowledge were pre-test and post-test, for skills of labour/delivery checklist of performance was used, and perception forms were filled to evaluate workshops/learning environment by students. Of the 76 participants, there were 36(47.4%) in group A and 40(52.6%) in group B. The overall mean age of the participants was 20.86±0.76 years in group B and 20.60±0.95 years in group A (p=0.19). The mean grade point average of the participants was 2.89±0.47 in group A and 2.87±0.48 in group B (p=0.81).Group B performed much better in skill of delivery having a mean score of 8.91±3.20compared to group A which had mean of 5.67±1.84 (pSimulation-based skill learning showed significantly better results.

Exploration of Environmental Management

OpenAIRE

Li Shushu; Li Ruilong; Chen Rui

2012-01-01

On the basis of domestic and international research, this article takes research on peasant household and agricultural managements as base points, aims to build environmental management model, establish government-led, an effective environmental management mechanism between the government and peasant household. Analyzes the role of peasant household’ environmental management in the regional environmental improvement from the aspect of theoretical analysis and analyze significant factors affec...

Quality assurance for online adapted treatment plans: Benchmarking and delivery monitoring simulation

International Nuclear Information System (INIS)

Li, Taoran; Wu, Qiuwen; Yang, Yun; Rodrigues, Anna; Yin, Fang-Fang; Jackie Wu, Q.

2015-01-01

Purpose: An important challenge facing online adaptive radiation therapy is the development of feasible and efficient quality assurance (QA). This project aimed to validate the deliverability of online adapted plans and develop a proof-of-concept online delivery monitoring system for online adaptive radiation therapy QA. Methods: The first part of this project benchmarked automatically online adapted prostate treatment plans using traditional portal dosimetry IMRT QA. The portal dosimetry QA results of online adapted plans were compared to original (unadapted) plans as well as randomly selected prostate IMRT plans from our clinic. In the second part, an online delivery monitoring system was designed and validated via a simulated treatment with intentional multileaf collimator (MLC) errors. This system was based on inputs from the dynamic machine information (DMI), which continuously reports actual MLC positions and machine monitor units (MUs) at intervals of 50 ms or less during delivery. Based on the DMI, the system performed two levels of monitoring/verification during the delivery: (1) dynamic monitoring of cumulative fluence errors resulting from leaf position deviations and visualization using fluence error maps (FEMs); and (2) verification of MLC positions against the treatment plan for potential errors in MLC motion and data transfer at each control point. Validation of the online delivery monitoring system was performed by introducing intentional systematic MLC errors (ranging from 0.5 to 2 mm) to the DMI files for both leaf banks. These DMI files were analyzed by the proposed system to evaluate the system’s performance in quantifying errors and revealing the source of errors, as well as to understand patterns in the FEMs. In addition, FEMs from 210 actual prostate IMRT beams were analyzed using the proposed system to further validate its ability to catch and identify errors, as well as establish error magnitude baselines for prostate IMRT delivery

Quality assurance for online adapted treatment plans: Benchmarking and delivery monitoring simulation

Energy Technology Data Exchange (ETDEWEB)

Li, Taoran, E-mail: taoran.li.duke@gmail.com; Wu, Qiuwen; Yang, Yun; Rodrigues, Anna; Yin, Fang-Fang; Jackie Wu, Q. [Department of Radiation Oncology, Duke University Medical Center Durham, North Carolina 27710 (United States)

2015-01-15

Purpose: An important challenge facing online adaptive radiation therapy is the development of feasible and efficient quality assurance (QA). This project aimed to validate the deliverability of online adapted plans and develop a proof-of-concept online delivery monitoring system for online adaptive radiation therapy QA. Methods: The first part of this project benchmarked automatically online adapted prostate treatment plans using traditional portal dosimetry IMRT QA. The portal dosimetry QA results of online adapted plans were compared to original (unadapted) plans as well as randomly selected prostate IMRT plans from our clinic. In the second part, an online delivery monitoring system was designed and validated via a simulated treatment with intentional multileaf collimator (MLC) errors. This system was based on inputs from the dynamic machine information (DMI), which continuously reports actual MLC positions and machine monitor units (MUs) at intervals of 50 ms or less during delivery. Based on the DMI, the system performed two levels of monitoring/verification during the delivery: (1) dynamic monitoring of cumulative fluence errors resulting from leaf position deviations and visualization using fluence error maps (FEMs); and (2) verification of MLC positions against the treatment plan for potential errors in MLC motion and data transfer at each control point. Validation of the online delivery monitoring system was performed by introducing intentional systematic MLC errors (ranging from 0.5 to 2 mm) to the DMI files for both leaf banks. These DMI files were analyzed by the proposed system to evaluate the system’s performance in quantifying errors and revealing the source of errors, as well as to understand patterns in the FEMs. In addition, FEMs from 210 actual prostate IMRT beams were analyzed using the proposed system to further validate its ability to catch and identify errors, as well as establish error magnitude baselines for prostate IMRT delivery

Quality assurance for online adapted treatment plans: benchmarking and delivery monitoring simulation.

Science.gov (United States)

Li, Taoran; Wu, Qiuwen; Yang, Yun; Rodrigues, Anna; Yin, Fang-Fang; Jackie Wu, Q

2015-01-01

An important challenge facing online adaptive radiation therapy is the development of feasible and efficient quality assurance (QA). This project aimed to validate the deliverability of online adapted plans and develop a proof-of-concept online delivery monitoring system for online adaptive radiation therapy QA. The first part of this project benchmarked automatically online adapted prostate treatment plans using traditional portal dosimetry IMRT QA. The portal dosimetry QA results of online adapted plans were compared to original (unadapted) plans as well as randomly selected prostate IMRT plans from our clinic. In the second part, an online delivery monitoring system was designed and validated via a simulated treatment with intentional multileaf collimator (MLC) errors. This system was based on inputs from the dynamic machine information (DMI), which continuously reports actual MLC positions and machine monitor units (MUs) at intervals of 50 ms or less during delivery. Based on the DMI, the system performed two levels of monitoring/verification during the delivery: (1) dynamic monitoring of cumulative fluence errors resulting from leaf position deviations and visualization using fluence error maps (FEMs); and (2) verification of MLC positions against the treatment plan for potential errors in MLC motion and data transfer at each control point. Validation of the online delivery monitoring system was performed by introducing intentional systematic MLC errors (ranging from 0.5 to 2 mm) to the DMI files for both leaf banks. These DMI files were analyzed by the proposed system to evaluate the system's performance in quantifying errors and revealing the source of errors, as well as to understand patterns in the FEMs. In addition, FEMs from 210 actual prostate IMRT beams were analyzed using the proposed system to further validate its ability to catch and identify errors, as well as establish error magnitude baselines for prostate IMRT delivery. Online adapted plans were

Health information needs of professional nurses required at the point of care

Directory of Open Access Journals (Sweden)

Esmeralda Ricks

2015-06-01

Conclusion: This study has enabled the researcher to identify the information needs required by professional nurses at the point of care to enhance the delivery of patient care. The research results were used to develop a mobile library that could be accessed by professional nurses.

Interest in Insects: The Role of Entomology in Environmental Education

Science.gov (United States)

Weeks, Faith J.; Oseto, Christian Y.

2018-01-01

University-based outreach programs have a long history of offering environmental education programs to local schools, but often these lessons are not evaluated for their impact on teachers and students. The impact of these outreach efforts can be influenced by many things, but the instructional delivery method can affect how students are exposed to new topics or how confident teachers feel about incorporating new concepts into the classroom. A study was conducted with a series of university entomology outreach programs using insects as a vehicle for teaching environmental education. These programs were used to assess differences between three of the most common university-based outreach delivery methods (Scientist in the Classroom, Teacher Training Workshops, and Online Curriculum) for their effect on student interest and teacher self-efficacy. Surveys administered to 20 fifth grade classrooms found that the delivery method might not be as important as simply getting insects into activities. This study found that the lessons had a significant impact on student interest in environmental and entomological topics, regardless of treatment. All students found the lessons to be more interesting, valuable, and important over the course of the year. Treatment also did not influence teacher self-efficacy, as it remained high for all teachers. PMID:29473884

Oil-points - Designers means to evaluate sustainability of concepts

DEFF Research Database (Denmark)

Bey, Niki; Lenau, Torben Anker

1998-01-01

Designers have an essential influence on product design and are therefore one target group for environmental evaluation methods. This implies, that such evaluation methods have to meet designers requirements. Evaluation of sustainability of products is often done using formal Life Cycle Assessment....... This is investigated by means of three case studies where environmental impact is estimated using the EDIP method, the Eco-indicator 95 method, and the Oil Point method proposed by the authors. It is found that the results obtained using Oil Points are in acceptable conformity with the results obtained with more...

Comparing patient and healthcare worker experiences during a dengue outbreak in Singapore: understanding the patient journey and the introduction of a point-of-care test (POCT) toward better care delivery.

Science.gov (United States)

Tan, Qinghui; Hildon, Zoe J-L; Singh, Shweta; Jing, Jin; Thein, Tun Linn; Coker, Richard; Vrijhoef, Hubertus J M; Leo, Yee Sin

2017-07-19

In the aftermath of an upsurge in the number of dengue cases in 2013 and 2014, the SD BIOLINE Dengue Duo rapid diagnostic Point-of-Care Test (POCT) kit was introduced in Tan Tock Seng Hospital, Singapore in June 2013. It is known that the success of POCT usage is contingent on its implementation within the health system. We evaluated health services delivery and the Dengue Duo rapid diagnostic test kit application in Singapore from healthcare workers' perspectives and patient experiences of dengue at surge times. Focus group discussions were conducted with dengue patients, from before and after the POCT implementation period. In-depth interviews with semi-structured components with healthcare workers were carried out. A patient centred process mapping technique was used for evaluation, which mapped the patient's journey and was mirrored from the healthcare worker's perspective. Patients and healthcare workers confirmed a wide range of symptoms in adults, making it challenging to determine diagnosis. There were multiple routes to help seeking, and no 'typical patient journey', with patients either presenting directly to the hospital emergency department, or being referred there by a primary care provider. Patients groups diagnosed before and after POCT implementation expressed some differences between speed of diagnoses and attitudes of doctors, yet shared negative feelings about waiting times and a lack of communication and poor information delivery. However, the POCT did not in its current implementation do much to help waiting times. Healthcare workers expressed that public perceptions of dengue in recent years was a major factor in changing patient management, and that the POCT kit was helpful in improving the speed and accuracy of diagnoses. Health service delivery for dengue patients in Singapore was overall perceived to be of an acceptable clinical standard, which was enhanced by the introduction of the POCT. However, improvements can be focused on Adapting

Determining decoupling points in a supply chain networks using NSGA II algorithm

Energy Technology Data Exchange (ETDEWEB)

Ebrahimiarjestan, M.; Wang, G.

2017-07-01

Purpose: In the model, we used the concepts of Lee and Amaral (2002) and Tang and Zhou (2009) and offer a multi-criteria decision-making model that identify the decoupling points to aim to minimize production costs, minimize the product delivery time to customer and maximize their satisfaction. Design/methodology/approach: We encounter with a triple-objective model that meta-heuristic method (NSGA II) is used to solve the model and to identify the Pareto optimal points. The max (min) method was used. Findings: Our results of using NSGA II to find Pareto optimal solutions demonstrate good performance of NSGA II to extract Pareto solutions in proposed model that considers determining of decoupling point in a supply network. Originality/value: So far, several approaches to model the future have been proposed, of course, each of them modeled a part of this concept. This concept has been considered more general in the model that defined in follow. In this model, we face with a multi-criteria decision problem that includes minimization of the production costs and product delivery time to customers as well as customer consistency maximization.

Determining decoupling points in a supply chain networks using NSGA II algorithm

International Nuclear Information System (INIS)

Ebrahimiarjestan, M.; Wang, G.

2017-01-01

Purpose: In the model, we used the concepts of Lee and Amaral (2002) and Tang and Zhou (2009) and offer a multi-criteria decision-making model that identify the decoupling points to aim to minimize production costs, minimize the product delivery time to customer and maximize their satisfaction. Design/methodology/approach: We encounter with a triple-objective model that meta-heuristic method (NSGA II) is used to solve the model and to identify the Pareto optimal points. The max (min) method was used. Findings: Our results of using NSGA II to find Pareto optimal solutions demonstrate good performance of NSGA II to extract Pareto solutions in proposed model that considers determining of decoupling point in a supply network. Originality/value: So far, several approaches to model the future have been proposed, of course, each of them modeled a part of this concept. This concept has been considered more general in the model that defined in follow. In this model, we face with a multi-criteria decision problem that includes minimization of the production costs and product delivery time to customers as well as customer consistency maximization.

Interdelivery weight gain and risk of cesarean delivery following a prior vaginal delivery.

Science.gov (United States)

Dude, Annie M; Lane-Cordova, Abbi D; Grobman, William A

2017-09-01

Approximately one third of all deliveries in the United States are via cesarean. Previous research indicates weight gain during pregnancy is associated with an increased risk of cesarean delivery. It remains unclear, however, whether and to what degree weight gain between deliveries (ie, interdelivery weight gain) is associated with cesarean delivery in a subsequent pregnancy following a vaginal delivery. The objective of the study was to determine whether interdelivery weight gain is associated with an increased risk of intrapartum cesarean delivery following a vaginal delivery. This was a case-control study of women who had 2 consecutive singleton births of at least 36 weeks' gestation between 2005 and 2016, with a vaginal delivery in the index pregnancy. Women were excluded if they had a contraindication to a trial of labor (eg, fetal malpresentation or placenta previa) in the subsequent pregnancy. Maternal characteristics and delivery outcomes for both pregnancies were abstracted from the medical record. Maternal weight gain between deliveries was measured as the change in body mass index at delivery. Women who underwent a subsequent cesarean delivery were compared with those who had a repeat vaginal delivery using χ 2 statistics for categorical variables and Student t tests or analysis of variance for continuous variables. Multivariable logistic regression was used to determine whether interdelivery weight gain remained independently associated with intrapartum cesarean delivery after adjusting for potential confounders. Of 10,396 women who met eligibility criteria and had complete data, 218 (2.1%) had a cesarean delivery in the subsequent pregnancy. Interdelivery weight gain was significantly associated with cesarean delivery and remained significant in multivariable analysis for women with a body mass index increase of at least 2 kg/m 2 (adjusted odds ratio, 1.53, 95% confidence interval, 1.03-2.27 for a body mass index increase of 2 kg/m 2 to gained 2 kg

Rethinking mobile delivery: using Quick Response codes to access information at the point of need.

Science.gov (United States)

Lombardo, Nancy T; Morrow, Anne; Le Ber, Jeanne

2012-01-01

This article covers the use of Quick Response (QR) codes to provide instant mobile access to information, digital collections, educational offerings, library website, subject guides, text messages, videos, and library personnel. The array of uses and the value of using QR codes to push customized information to patrons are explained. A case is developed for using QR codes for mobile delivery of customized information to patrons. Applications in use at the Libraries of the University of Utah will be reviewed to provide readers with ideas for use in their library. Copyright © Taylor & Francis Group, LLC

eDelivery

Data.gov (United States)

US Agency for International Development — eDelivery provides the electronic packaging and delivery of closed and complete OPM investigation files to government agencies, including USAID, in a secure manner....

Understanding release kinetics of biopolymer drug delivery microcapsules for biomedical applications

International Nuclear Information System (INIS)

Desai, Salil; Perkins, Jessica; Harrison, Benjamin S.; Sankar, Jag

2010-01-01

Drug delivery and dosage concentrations are considered as major focal points in conventional as well as battlefield emergency medicine. The concept of localizing drug delivery via microcapsules is an evolving field to confine the adverse side effects of high concentration drug doses. This paper focuses on understanding release kinetics through biopolymer microcapsules for time-dependent drug release. Calcium alginate microcapsules were manufactured using a direct-write inkjet technique. Rhodamine 6G was used as the release agent to observe the release kinetics from calcium alginate beads in distilled water. A design of experiments was constructed to compare the effect of the microcapsule diameter and different concentrations of calcium chloride (M) and sodium alginate (%, w/v) solutions on the release kinetics profiles of the microcapsules. This research gives insight to identify favorable sizes of microcapsules and concentrations of sodium alginate and calcium chloride solutions for controlled release behavior of drug delivery microcapsules.

Survey of fishes and environmental conditions in Abbotts Lagoon, Point Reyes National Seashore, California

Science.gov (United States)

Saiki, M.K.; Martin, B.A.

2001-01-01

This study was conducted to gain a better understanding of fishery resources in Abbotts Lagoon, Point Reyes National Seashore. During February/March, May, August, and November 1999, fish were sampled with floating variable-mesh gill nets and small minnow traps from as many as 14 sites in the lagoon. Water temperature, dissolved oxygen, pH, total ammonia(NH3 + NH4+), salinity, turbidity, water depth, and bottom substrate composition were also measured at each site. A total of 2,656 fish represented by eight species was captured during the study. Gill nets captured Sacramento perch, Archoplites interruptus; largemouth bass, Micropterus salmoides; Pacific herring, Clupea pallasi; prickly sculpin, Cottus asper, silver surfperch, Hyperprosopon ellipticum; longfin smelt, Spirinchus thaleichthys; and striped bass, Morone saxatilis; whereas minnow traps captured Sacramento perch; prickly sculpin; and threespine stickleback, Gasterosteus aculeatus. Cluster analysis (Ward's minimum variance method of fish catch statistics identified two major species assemblages-the first dominated by Sacramento perch and, to a lesser extent, by largemouth bass, and the second dominated by Pacific herring and threespine stickleback. Simple discriminant analysis of environmental variables indicated that salinity contributed the most towards separating the two assemblages.

Cultural and Linguistic Imperatives in Public Health Delivery in Developing Countries.

Science.gov (United States)

Goke-Pariola, Abiodun

Some cultural realities and linguistic considerations are discussed that public health providers can use to make preventive health care delivery more effective and acceptable in several developing countries. The case of the Yoruba people of southwestern Nigeria is used as an example. Two points are addressed: the question of the usefulness of…

BIOLOGICAL AND ENVIRONMENTAL RADIATION EXPERIENCE AT INDIAN POINT STATION

Energy Technology Data Exchange (ETDEWEB)

Nelson, H. F.

1963-09-15

The environs monitoring program at Indian Point Station is presented. Thirty sampling stations within a circle of approximately 10 miles of the station are used for the collection of samples of air, water, vegetation, and soil that are then analyzed for gross beta-gamma activity. Data are tabulated. (P.C.H.)

UO3 deactivation end point criteria

International Nuclear Information System (INIS)

Stefanski, L.D.

1994-01-01

The UO 3 Deactivation End Point Criteria are necessary to facilitate the transfer of the UO 3 Facility from the Office of Facility Transition and Management (EM-60) to the office of Environmental Restoration (EM-40). The criteria were derived from a logical process for determining end points for the systems and spaces at the UO 3 , Facility based on the objectives, tasks, and expected future uses pertinent to that system or space. Furthermore, the established criteria meets the intent and supports the draft guidance for acceptance criteria prepared by EM-40, open-quotes U.S. Department of Energy office of Environmental Restoration (EM-40) Decontamination and Decommissioning Guidance Document (Draft).close quotes For the UO 3 Facility, the overall objective of deactivation is to achieve a safe, stable and environmentally sound condition, suitable for an extended period, as quickly and economically as possible. Once deactivated, the facility is kept in its stable condition by means of a methodical surveillance and maintenance (S ampersand M) program, pending ultimate decontamination and decommissioning (D ampersand D). Deactivation work involves a range of tasks, such as removal of hazardous material, elimination or shielding of radiation fields, partial decontamination to permit access for inspection, installation of monitors and alarms, etc. it is important that the end point of each of these tasks be established clearly and in advance, for the following reasons: (1) End points must be such that the central element of the deactivation objective - to achieve stability - is unquestionably achieved. (2) Much of the deactivation work involves worker exposure to radiation or dangerous materials. This can be minimized by avoiding unnecessary work. (3) Each task is, in effect, competing for resources with other deactivation tasks and other facilities. By assuring that each task is appropriately bounded, DOE's overall resources can be used most fully and effectively

Advancement in integrin facilitated drug delivery.

Science.gov (United States)

Arosio, Daniela; Casagrande, Cesare

2016-02-01

The research of integrin-targeted anticancer agents has recorded important advancements in ingenious design of delivery systems, based either on the prodrug approach, or on nanoparticle carriers, but for now, none of these has reached a clinical stage of development. Past work in this area has been extensively reviewed by us and others. Thus, the purpose and scope of the present review is to survey the advancement reported in the last 3years, with focus on innovative delivery systems that appear to afford openings for future developments. These systems exploit the labelling with conventional and novel integrin ligands for targeting the interface of cancer cells and of endothelial cells involved in cancer angiogenesis, with the proteins of the extracellular matrix, in the circulation, in tissues, and in tumour stroma, as the site of progression and metastatic evolution of the disease. Furthermore, these systems implement the expertise in the development of nanomedicines to the purpose of achieving preferential biodistribution and uptake in cancer tissues, internalisation in cancer cells, and release of the transported drugs at intracellular sites. The assessment of the value of controlling these factors, and their combination, for future developments requires support of biological testing in appropriate mechanistic models, but also imperatively demand confirmation in therapeutically relevant in vivo models for biodistribution, efficacy, and lack of off-target effects. Thus, among many studies, we have tried to point out the results supported by relevant in vivo studies, and we have emphasised in specific sections those addressing the medical needs of drug delivery to brain tumours, as well as the delivery of oligonucleotides modulating gene-dependent pathological mechanism. The latter could constitute the basis of a promising third branch in the therapeutic armamentarium against cancer, in addition to antibody-based agents and to cytotoxic agents. Copyright © 2015

Co-ordination of federal and provincial environmental assessment processes for the Point Lepreau Generating Station Solid Radioactive Waste Management Facility modifications

Energy Technology Data Exchange (ETDEWEB)

Hickman, C.; Thompson, P.D. [Point Lepreau Generating Station, Point Lepreau Refurbishment Project, Lepreau, New Brunswick (Canada); Barnes, J. [Jacques Whitford Environment Ltd., Fredericton, New Brunswick (Canada)

2006-07-01

Modification of the Solid Radioactive Waste Management Facility at Point Lepreau Generating Station is required to accommodate waste generated during and after an 18-month maintenance outage during which the station would be Refurbished. The modification of the facility triggered both federal and provincial environmental assessment requirements, and these assessments were conducted in a 'coordinated' and cooperative fashion. In this project, the coordinated approach worked well, and provided some significant advantages to the proponent, the public and the regulators. However, there are opportunities for further improvement in future projects, and this paper explores the advantages and disadvantages of this 'co-ordinated' approach. As part of this exploration, there is a discussion of administrative and regulatory changes that the province is considering for the environmental assessment process, and a discussion of the need for a formal 'harmonization' agreement. (author)

Corporate environmental management

DEFF Research Database (Denmark)

Madsen, Henning; Ulhøi, John Parm

With increasing population and economic growth and related demand for energy and natural resources as well, pollution, waste production and environmental sustainability have become issues of uttermost importance. For quite some time self-regulation, i.e. voluntary implementation of environmental......: how does industry respond to the environmental challenge? The paper concludes that despite the apparent attractiveness of self-regulation in industry, voluntary options tend not to be widely adopted thus pointing to a continued strong need for an effective regulation of industry’s environmental...

UAV Delivery Monitoring System

Directory of Open Access Journals (Sweden)

San Khin Thida

2018-01-01

Full Text Available UAV-based delivery systems are increasingly being used in the logistics field, particularly to achieve faster last-mile delivery. This study develops a UAV delivery system that manages delivery order assignments, autonomous flight operation, real time control for UAV flights, and delivery status tracking. To manage the delivery item assignments, we apply the concurrent scheduler approach with a genetic algorithm. The present paper describes real time flight data based on a micro air vehicle communication protocol (MAVLink. It also presents the detailed hardware components used for the field tests. Finally, we provide UAV component analysis to choose the suitable components for delivery in terms of battery capacity, flight time, payload weight and motor thrust ratio.

Outcome of deliveries in healthy but obese women: obesity and delivery outcome

Directory of Open Access Journals (Sweden)

Kaplan-Sturk Rebecka

2013-02-01

Full Text Available Abstract Background Obesity among fertile women is a global problem. 25% of pregnant Swedish women are overweight at admission to the antenatal clinic and 12% of them are considered as obese. Previous studies have shown an increased risk of delivery complications with an elevated maternal BMI. The aim of this study was to evaluate delivery outcomes in relation to maternal BMI on admission to the antenatal clinic. A healthy group of 787 women with full-term pregnancies and spontaneous onset of labor were included in the study. Delivery outcome was assessed in relation to maternal BMI when attending the antenatal clinic. Results The results indicated that in deliveries where the maternal BMI was >30 a high frequency of abnormal CTG trace during the last 30 minutes of labor was shown. A blood sample for evaluation of risk of fetal hypoxia was performed in only eight percent of these deliveries. A spontaneous vaginal delivery without intervention was noted in 85.7%, and 12% of neonates were delivered with an adverse fetal outcome compared to 2.8% in the group with a maternal BMI Conclusion These results indicate an increased risk at delivery for healthy, but obese women in labor. Furthermore, the delivery management may not always be optimal in these deliveries.

Timing of delivery after external cephalic version and the risk for cesarean delivery.

Science.gov (United States)

Kabiri, Doron; Elram, Tamar; Aboo-Dia, Mushira; Elami-Suzin, Matan; Elchalal, Uriel; Ezra, Yossef

2011-08-01

To estimate the association between time of delivery after external cephalic version at term and the risk for cesarean delivery. This retrospective cohort study included all successful external cephalic versions performed in a tertiary center between January 1997 and January 2010. Stepwise logistic regression was used to calculate the odds ratio (OR) for cesarean delivery. We included 483 external cephalic versions in this study, representing 53.1% of all external cephalic version attempts. The incidence of cesarean delivery for 139 women (29%) who gave birth less than 96 hours from external cephalic version was 16.5%; for 344 women (71%) who gave birth greater than 96 hours from external cephalic version, the incidence of cesarean delivery was 7.8% (P = .004). The adjusted OR for cesarean delivery was 2.541 (95% confidence interval 1.36-4.72). When stratified by parity, the risk for cesarean delivery when delivery occurred less than 96 hours after external cephalic version was 2.97 and 2.28 for nulliparous and multiparous women, respectively. Delivery at less than 96 hours after successful external cephalic version was associated with an increased risk for cesarean delivery. III.

Environmental Performance

DEFF Research Database (Denmark)

Lindelof, Anja Mølle; Schmidt, Ulrik; Svabo, Connie

2017-01-01

Do ants and grasshoppers perform? Do clouds, plants and melting ice? Do skyscrapers, traffic jams and computer vira? And what happens to our understanding of liveness if that is the case? This chapter takes ongoing theoretical disputes about the nature of live performance in performance studies...... as its starting point to investigate liveness within a specific kind of contemporary performance: ‘environmental performances’. Environmental performances are arts practices that take environmental processes as their focus by framing activities of non-human performers such as clouds, wind and weeds - key...

Recent Advances in Non-viral Vectors for Gene Delivery

Science.gov (United States)

Guo, Xia; Huang, Leaf

2011-01-01

CONSPECTUS Non-viral vectors, typically based on cationic lipids or polymers, are preferred due to safety concerns with viral vectors. So far, non-viral vectors can proficiently transfect cells in culture, but obtaining efficient nanomedicines is far from evident. To overcome the hurdles associated with non-viral vectors is significant for improving delivery efficiency and therapeutic effect of nucleic acid. The drawbacks include the strong interaction of cationic delivery vehicles with blood components, uptake by the reticuloendothelial system (RES), toxicity, targeting ability of the carriers to the cells of interest, and so on. PEGylation is the predominant method used to reduce the binding of plasma proteins with non-viral vectors and minimize the clearance by RES after intravenous administration. The nanoparticles that are not rapidly cleared from the circulation accumulate in the tumors due to the enhanced permeability and retention effect, and the targeting ligands attached to the distal end of the PEGylated components allow binding to the receptors on the target cell surface. Neutral or anionic liposomes have been also developed for systemic delivery of nucleic acids in experimental animal model. Designing and synthesizing novel cationic lipids and polymers, and binding nucleic acid with peptides, targeting ligands, polymers, or environmentally sensitive moieties also attract many attentions for resolving the problems encountered by non-viral vectors. The application of inorganic nanoparticles in nucleic acid delivery is an emerging field, too. Recently, different classes of non-viral vectors appear to be converging and the features of different classes of non-viral vectors could be combined in one strategy. More hurdles associated with efficient nucleic acid delivery therefore might be expected to be overcome. In this account, we will focus on these novel non-viral vectors, which are classified into multifunctional hybrid nucleic acid vectors, novel

Estimating the cost of healthcare delivery in three hospitals in southern ghana.

Science.gov (United States)

Aboagye, A Q Q; Degboe, A N K; Obuobi, A A D

2010-09-01

The cost burden (called full cost) of providing health services at a referral, a district and a mission hospital in Ghana were determined. Standard cost-finding and cost analysis tools recommended by World Health Organization are used to analyse 2002 and 2003 hospital data. Full cost centre costs were computed by taking into account cash and non-cash expenses and allocating overhead costs to intermediate and final patient care centres. The full costs of running the mission hospital in 2002 and 2003 were US$600,295 and US$758,647 respectively; for the district hospital, the respective costs were US$496,240 and US$487,537; and for the referral hospital, the respective costs were US$1,160,535 and US$1,394,321. Of these, overhead costs ranged between 20% and 42%, while salaries made up between 45% and 60%. Based on healthcare utilization data, in 2003 the estimated cost per outpatient attendance was US$ 2.25 at the mission hospital, US$ 4.51 at the district hospital and US$8.5 at the referral hospital; inpatient day costs were US$ 6.05, US$ 9.95 and US$18.8 at the respective hospitals. User fees charged at service delivery points were generally below cost. However, some service delivery points have the potential to recover their costs. Salaries are the major cost component of the three hospitals. Overhead costs constitute an important part of hospital costs and must be noted in efforts to recover costs. Cost structures are different at different types of hospitals. Unit costs at service delivery points can be estimated and projected into the future.

Water Sample Points, Navajo Nation, 2000, USACE

Data.gov (United States)

U.S. Environmental Protection Agency — This point shapefile presents the locations and results for water samples collected on the Navajo Nation by the US Army Corps of Engineers (USACE) for the US...

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Directory of Open Access Journals (Sweden)

Song Y

2016-12-01

Full Text Available Yuanhui Song, Yihong Li, Qien Xu, Zhe Liu Wenzhou Institute of Biomaterials and Engineering (WIBE, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China Abstract: With the development of nanotechnology, the application of nanomaterials in the field of drug delivery has attracted much attention in the past decades. Mesoporous silica nanoparticles as promising drug nanocarriers have become a new area of interest in recent years due to their unique properties and capabilities to efficiently entrap cargo molecules. This review describes the latest advances on the application of mesoporous silica nanoparticles in drug delivery. In particular, we focus on the stimuli-responsive controlled release systems that are able to respond to intracellular environmental changes, such as pH, ATP, GSH, enzyme, glucose, and H2O2. Moreover, drug delivery induced by exogenous stimuli including temperature, light, magnetic field, ultrasound, and electricity is also summarized. These advanced technologies demonstrate current challenges, and provide a bright future for precision diagnosis and treatment. Keywords: mesoporous silica nanoparticle, drug delivery system, controlled release, stimuli-responsive, chemotherapy

The use of dextrose/insulin infusions during labour and delivery in women with gestational diabetes mellitus: Is there any point?

Science.gov (United States)

Farrant, Maritza T; Williamson, Kathryn; Battin, Malcolm; Hague, William M; Rowan, Janet A

2017-06-01

We compared, in 733 women with gestational diabetes mellitus treated with metformin and/or insulin, rates of neonatal hypoglycaemia in those who had received a dextrose/insulin infusion during labour and prior to delivery (n = 132) with those who did not (n = 601). Women who had infusions were more likely to have been treated with insulin (87.1% vs 70.4%, P < 0.01) and have higher mean capillary glucose values (measured four times daily) in the two weeks prior to delivery (P < 0.01). They had lower mean (SD) glucose values in the 12 h prior to delivery (5.1 (1.1) mmol/L vs 5.4 (0.9) mmol/L, P < 0.01). There was no difference between the groups in rates of neonatal hypoglycaemia (glucose <2.6 mmol/L on two or more occasions), 15.9% versus 17.8%, P = 0.78, or of severe neonatal hypoglycaemia (one or more glucose <1.6 mmol/L), 8.3% versus 5.2%, P = 0.15. In the absence of randomised data comparing use of infusions with no infusions, these data are reassuring for clinicians who do not routinely use infusions. © 2016 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.

Environmental impacts of beef production: Review of challenges and perspectives for durability.

Science.gov (United States)

Gerber, Pierre J; Mottet, Anne; Opio, Carolyn I; Falcucci, Alessandra; Teillard, Félix

2015-11-01

Beef makes a substantial contribution to food security, providing protein, energy and also essential micro-nutrients to human populations. Rumination allows cattle - and other ruminant species - to digest fibrous feeds that cannot be directly consumed by humans and thus to make a net positive contribution to food balances. This contribution is of particular importance in marginal areas, where agro-ecological conditions and weak infrastructures do not offer much alternative. It is also valuable where cattle convert crop residues and by-products into edible products and where they contribute to soil fertility through their impact on nutrients and organic matter cycles. At the same time, environmental sustainability issues are acute. They chiefly relate to the low efficiency of beef cattle in converting natural resources into edible products. Water use, land use, biomass appropriation and greenhouse gas emissions are for example typically higher per unit of edible product in beef systems than in any other livestock systems, even when corrected for nutritional quality. This particularly causes environmental pressure when production systems are specialized towards the delivery of edible products, in large volumes. The paper discusses environmental challenges at global level, recognizing the large diversity of systems. Beef production is faced with a range of additional sustainability challenges, such as changing consumer perceptions, resilience to climate change, animal health and inequities in access to land and water resources. Entry-points for environmental sustainability improvement are discussed within this broader development context. Copyright © 2015. Published by Elsevier Ltd.

Heat: A Highly Efficient Skin Enhancer for Transdermal Drug Delivery

Directory of Open Access Journals (Sweden)

Sabine Szunerits

2018-02-01

Full Text Available Advances in materials science and bionanotechnology have allowed the refinements of current drug delivery systems, expected to facilitate the development of personalized medicine. While dermatological topical pharmaceutical formulations such as foams, creams, lotions, gels, etc., have been proposed for decades, these systems target mainly skin-based diseases. To treat systemic medical conditions as well as localized problems such as joint or muscle concerns, transdermal delivery systems (TDDSs, which use the skin as the main route of drug delivery, are very appealing. Over the years, these systems have shown to offer important advantages over oral as well as intravenous drug delivery routes. Besides being non-invasive and painless, TDDSs are able to deliver drugs with a short-half-life time more easily and are well adapted to eliminate frequent administrations to maintain constant drug delivery. The possibility of self-administration of a predetermined drug dose at defined time intervals makes it also the most convenient personalized point-of-care approach. The transdermal market still remains limited to a narrow range of drugs. While small and lipophilic drugs have been successfully delivered using TDDSs, this approach fails to deliver therapeutic macromolecules due to size-limited transport across the stratum corneum, the outermost layer of the epidermis. The low permeability of the stratum corneum to water-soluble drugs as well as macromolecules poses important challenges to transdermal administration. To widen the scope of drugs for transdermal delivery, new procedures to enhance skin permeation to hydrophilic drugs and macromolecules are under development. Next to iontophoresis and microneedle-based concepts, thermal-based approaches have shown great promise to enhance transdermal drug delivery of different therapeutics. In this inaugural article for the section “Frontiers in Bioengineering and Biotechnology,” the advances in this field

Heat: A Highly Efficient Skin Enhancer for Transdermal Drug Delivery

Science.gov (United States)

Szunerits, Sabine; Boukherroub, Rabah

2018-01-01

Advances in materials science and bionanotechnology have allowed the refinements of current drug delivery systems, expected to facilitate the development of personalized medicine. While dermatological topical pharmaceutical formulations such as foams, creams, lotions, gels, etc., have been proposed for decades, these systems target mainly skin-based diseases. To treat systemic medical conditions as well as localized problems such as joint or muscle concerns, transdermal delivery systems (TDDSs), which use the skin as the main route of drug delivery, are very appealing. Over the years, these systems have shown to offer important advantages over oral as well as intravenous drug delivery routes. Besides being non-invasive and painless, TDDSs are able to deliver drugs with a short-half-life time more easily and are well adapted to eliminate frequent administrations to maintain constant drug delivery. The possibility of self-administration of a predetermined drug dose at defined time intervals makes it also the most convenient personalized point-of-care approach. The transdermal market still remains limited to a narrow range of drugs. While small and lipophilic drugs have been successfully delivered using TDDSs, this approach fails to deliver therapeutic macromolecules due to size-limited transport across the stratum corneum, the outermost layer of the epidermis. The low permeability of the stratum corneum to water-soluble drugs as well as macromolecules poses important challenges to transdermal administration. To widen the scope of drugs for transdermal delivery, new procedures to enhance skin permeation to hydrophilic drugs and macromolecules are under development. Next to iontophoresis and microneedle-based concepts, thermal-based approaches have shown great promise to enhance transdermal drug delivery of different therapeutics. In this inaugural article for the section “Frontiers in Bioengineering and Biotechnology,” the advances in this field and the handful of

Environmental ethics - connections between the environmental protection movement and the churches. Umweltethik - Verbindungen zwischen Umweltbewegung und Kirche

Energy Technology Data Exchange (ETDEWEB)

Breuer, W.

1986-11-01

The crisis of the environment as a part of a much more comprehensive, deeper crisis of man in modern civilization - this, and the question for the causes of the crisis are the subjects of the book. Focal points of environmental ethics which are also points establishing a connection to the churches - brown coal open-pit mining in the Rhine-and-Ruhr district, the nuclear power plant site Pfaffenhofen, and road planning in the Rinnebach valley - continue the introductory part on 'Environment and christianity'. 'Perspectives of environmental ethics' draw up a conceptional framework to consider environmental ethics in the discussion about environmental politics. (HSCH).

Construction of a controlled-release delivery system for pesticides using biodegradable PLA-based microcapsules.

Science.gov (United States)

Liu, Baoxia; Wang, Yan; Yang, Fei; Wang, Xing; Shen, Hong; Cui, Haixin; Wu, Decheng

2016-08-01

Conventional pesticides usually need to be used in more than recommended dosages due to their loss and degradation, which results in a large waste of resources and serious environmental pollution. Encapsulation of pesticides in biodegradable carriers is a feasible approach to develop environment-friendly and efficient controlled-release delivery system. In this work, we fabricated three kinds of polylactic acid (PLA) carriers including microspheres, microcapsules, and porous microcapsules for controlled delivery of Lambda-Cyhalothrin (LC) via premix membrane emulsification (PME). The microcapsule delivery system had better water dispersion than the other two systems. Various microcapsules with a high LC contents as much as 40% and tunable sizes from 0.68 to 4.6μm were constructed by manipulating the process parameters. Compared with LC technical and commercial microcapsule formulation, the microcapsule systems showed a significantly sustained release of LC for a longer period. The LC release triggered by LC diffusion and matrix degradation could be optimally regulated by tuning LC contents and particle sizes of the microcapsules. This multi-regulated release capability is of great significance to achieve the precisely controlled release of pesticides. A preliminary bioassay against plutella xylostella revealed that 0.68μm LC-loaded microcapsules with good UV and thermal stability exhibited an activity similar to a commercial microcapsule formulation. These results demonstrated such an aqueous microcapsule delivery system had a great potential to be further explored for developing an effective and environmentally friendly pesticide-release formulation. Copyright © 2016 Elsevier B.V. All rights reserved.

Nursing Services Delivery Theory: an open system approach

Science.gov (United States)

Meyer, Raquel M; O’Brien-Pallas, Linda L

2010-01-01

meyer r.m. & o’brien-pallas l.l. (2010)Nursing services delivery theory: an open system approach. Journal of Advanced Nursing66(12), 2828–2838. Aim This paper is a discussion of the derivation of the Nursing Services Delivery Theory from the application of open system theory to large-scale organizations. Background The underlying mechanisms by which staffing indicators influence outcomes remain under-theorized and unmeasured, resulting in a ‘black box’ that masks the nature and organization of nursing work. Theory linking nursing work, staffing, work environments, and outcomes in different settings is urgently needed to inform management decisions about the allocation of nurse staffing resources in organizations. Data sources A search of CINAHL and Business Source Premier for the years 1980–2008 was conducted using the following terms: theory, models, organization, organizational structure, management, administration, nursing units, and nursing. Seminal works were included. Discussion The healthcare organization is conceptualized as an open system characterized by energy transformation, a dynamic steady state, negative entropy, event cycles, negative feedback, differentiation, integration and coordination, and equifinality. The Nursing Services Delivery Theory proposes that input, throughput, and output factors interact dynamically to influence the global work demands placed on nursing work groups at the point of care in production subsystems. Implications for nursing The Nursing Services Delivery Theory can be applied to varied settings, cultures, and countries and supports the study of multi-level phenomena and cross-level effects. Conclusion The Nursing Services Delivery Theory gives a relational structure for reconciling disparate streams of research related to nursing work, staffing, and work environments. The theory can guide future research and the management of nursing services in large-scale healthcare organizations. PMID:20831573

Hair Mercury Negatively Correlates with Calcium Pump Activity in Human Term Newborns and Their Mothers at Delivery

OpenAIRE

Huel, Guy; Sahuquillo, Josiane; Debotte, Ginette; Oury, Jean-François; Takser, Larissa

2007-01-01

Background Calcium homeostasis is a known target of several environmental toxicants including lead and mercury. Objective Our goal was to determine the relationship between Hg exposure and erythrocyte Ca pump activity in women at delivery and in their newborns. Methods We determined total Hg as well as Pb concentrations in 81 hair and blood samples obtained at delivery. Basal and calmodulin-stimulated Ca pump activity was measured in red blood cells from cord blood and maternal erythrocyte pl...

Holocene environmental changes in Red River Delta, Vietnam as ...

Indian Academy of Sciences (India)

63

2VNU Key Laboratory of Geoenvironment and Climate change Response – 334 ... Keywords: Environmental change; Stable isotopes; C/N ratios; Red River ...... and Meade R H 1983 World-wide delivery of river sediment to the oceans; The.

Improved overall delivery documentation following implementation of a standardized shoulder dystocia delivery form

Science.gov (United States)

Moragianni, Vasiliki A.; Hacker, Michele R.; Craparo, Frank J.

2013-01-01

Objective Our objective was to evaluate whether using a standardized shoulder dystocia delivery form improved documentation. A standardized delivery form was added to our institution’s obstetrical record in August 2003. Methods A retrospective cohort study was conducted comparing 100 vaginal deliveries complicated by shoulder dystocia before, and 81 after implementation of the standardized delivery form. The two groups were compared in terms of obstetric characteristics, neonatal outcomes and documentation components. Results Charts that included the standardized delivery form were more likely to contain documentation of estimated fetal weight (82.7% vs. 39.0% without the form, Pdystocia, and second stage duration. Conclusions Inclusion of a standardized form in the delivery record improves the rate of documentation of both shoulder dystocia-specific and general delivery components. PMID:22017330

Environmental communication research in Finland; Ympaeristoeviestinnaen tutkimus Suomessa

Energy Technology Data Exchange (ETDEWEB)

Lyytimaeki, J.; Palosaari, M.

2004-07-01

This report presents Finnish research on environmental communication and describes different was of understanding the term environmental communication. The objective of the report is to indicate relevant topics for future research in environmental communication from the point of view of environmental policy research and Finnish environmental administration. The report outlines the development of environmental journalism from the 1960's till present and explores the different approaches taken in researching environmental communication. Or organisation and crisis communication, sociology, environmental education and policy are current y the fields of science most active in environmental communication research. Visuality of communication and the effects of new information technology are increasingly interesting phenomena for the study of environmental communication. This report points out needs of research from each of these fields. The report includes also a bibliography of environmental communication research in Finland. (orig.)

Determinants of choice of delivery place: Testing rational choice theory and habitus theory.

Science.gov (United States)

Broda, Anja; Krüger, Juliane; Schinke, Stephanie; Weber, Andreas

2018-05-07

The current study uses two antipodal social science theories, the rational choice theory and the habitus theory, and applies these to describe how women choose between intraclinical (i.e., hospital-run birth clinics) and extraclinical (i.e., midwife-led birth centres or home births) delivery places. Data were collected in a cross-sectional questionnaire-based survey among 189 women. A list of 22 determinants, conceptualized to capture the two theoretical concepts, were rated on a 7-point Likert scale with 1 = unimportant to 7 = very important. The analytic method was structural equation modelling. A model was built, in which the rational choice theory and the habitus theory as latent variables predicted the choice of delivery place. With regards to the choice of delivery place, 89.3% of the women wanted an intraclinical and 10.7% an extraclinical delivery place at the time of their last child's birth. Significant differences between women with a choice of an intraclinical or extraclinical delivery place were found for 14 of the 22 determinants. In the structural equation model, rational choice theory determinants predicted a choice of intraclinical delivery and habitus theory determinants predicted a choice of extraclinical delivery. The two theories had diametrically opposed effects on the choice of delivery place. Women are more likely to decide on intraclinical delivery when arguments such as high medical standards, positive evaluations, or good advanced information are rated important. In contrast, women are more likely to decide on extraclinical delivery when factors such as family atmosphere during birth, friendliness of health care professionals, or consideration of the woman's interests are deemed important. A practical implication of our study is that intraclinical deliveries may be promoted by providing comprehensive information, data and facts on various delivery-related issues, while extraclinical deliveries may be fostered by healthcare

Brain matters: from environmental ethics to environmental neuroethics.

Science.gov (United States)

Cabrera, Laura Y; Tesluk, Jordan; Chakraborti, Michelle; Matthews, Ralph; Illes, Judy

2016-02-15

The ways in which humans affect and are affected by their environments have been studied from many different perspectives over the past decades. However, it was not until the 1970s that the discussion of the ethical relationship between humankind and the environment formalized as an academic discipline with the emergence of environmental ethics. A few decades later, environmental health emerged as a discipline focused on the assessment and regulation of environmental factors that affect living beings. Our goal here is to begin a discussion specifically about the impact of modern environmental change on biomedical and social understandings of brain and mental health, and to align this with ethical considerations. We refer to this focus as Environmental Neuroethics, offer a case study to illustrate key themes and issues, and conclude by offering a five-tier framework as a starting point of analysis.

Geographic Response Plan (GRP) Sensitive Site Points (Editable), Guam, 2016, US EPA Region 9

Data.gov (United States)

U.S. Environmental Protection Agency — This is an editable point feature data set with points over Apra Harbor in Guam. These points represent sensitive sites such as access points for public use and...

Multifunctional Nanoparticles for Drug Delivery Applications Imaging, Targeting, and Delivery

CERN Document Server

Prud'homme, Robert

2012-01-01

This book clearly demonstrates the progression of nanoparticle therapeutics from basic research to applications. Unlike other books covering nanoparticles used in medical applications, Multifunctional Nanoparticles for Drug Delivery Applications presents the medical challenges that can be reduced or even overcome by recent advances in nanoscale drug delivery. Each chapter highlights recent progress in the design and engineering of select multifunctional nanoparticles with topics covering targeting, imaging, delivery, diagnostics, and therapy.

Nursing Services Delivery Theory: an open system approach.

Science.gov (United States)

Meyer, Raquel M; O'Brien-Pallas, Linda L

2010-12-01

This paper is a discussion of the derivation of the Nursing Services Delivery Theory from the application of open system theory to large-scale organizations. The underlying mechanisms by which staffing indicators influence outcomes remain under-theorized and unmeasured, resulting in a 'black box' that masks the nature and organization of nursing work. Theory linking nursing work, staffing, work environments, and outcomes in different settings is urgently needed to inform management decisions about the allocation of nurse staffing resources in organizations. A search of CINAHL and Business Source Premier for the years 1980-2008 was conducted using the following terms: theory, models, organization, organizational structure, management, administration, nursing units, and nursing. Seminal works were included. The healthcare organization is conceptualized as an open system characterized by energy transformation, a dynamic steady state, negative entropy, event cycles, negative feedback, differentiation, integration and coordination, and equifinality. The Nursing Services Delivery Theory proposes that input, throughput, and output factors interact dynamically to influence the global work demands placed on nursing work groups at the point of care in production subsystems. THE Nursing Services Delivery Theory can be applied to varied settings, cultures, and countries and supports the study of multi-level phenomena and cross-level effects. The Nursing Services Delivery Theory gives a relational structure for reconciling disparate streams of research related to nursing work, staffing, and work environments. The theory can guide future research and the management of nursing services in large-scale healthcare organizations. © 2010 Blackwell Publishing Ltd.

Redesigning ambulatory care business processes supporting clinical care delivery.

Science.gov (United States)

Patterson, C; Sinkewich, M; Short, J; Callas, E

1997-04-01

The first step in redesigning the health care delivery process for ambulatory care begins with the patient and the business processes that support the patient. Patient-related business processes include patient access, service documentation, billing, follow-up, collection, and payment. Access is the portal to the clinical delivery and care management process. Service documentation, charge capture, and payment and collection are supporting processes to care delivery. Realigned provider networks now demand realigned patient business services to provide their members/customers/patients with improved service delivery at less cost. Purchaser mandates for cost containment, health maintenance, and enhanced quality of care have created an environment where every aspect of the delivery system, especially ambulatory care, is being judged. Business processes supporting the outpatient are therefore being reexamined for better efficiency and customer satisfaction. Many health care systems have made major investments in their ambulatory care environment, but have pursued traditional supporting business practices--such as multiple access points, lack of integrated patient appointment scheduling and registration, and multiple patient bills. These are areas that are appropriate for redesign efforts--all with the customer's needs and convenience in mind. Similarly, setting unrealistic expectations, underestimating the effort required, and ignoring the human elements of a patient-focused business service redesign effort can sabotage the very sound reasons for executing such an endeavor. Pitfalls can be avoided if a structured methodology, coupled with a change management process, are employed. Deloitte & Touche Consulting Group has been involved in several major efforts, all with ambulatory care settings to assist with the redesign of their business practices to consider the patient as the driver, instead of the institution providing the care.

Evaluation of multiple emission point facilities

International Nuclear Information System (INIS)

Miltenberger, R.P.; Hull, A.P.; Strachan, S.; Tichler, J.

1988-01-01

In 1970, the New York State Department of Environmental Conservation (NYSDEC) assumed responsibility for the environmental aspect of the state's regulatory program for by-product, source, and special nuclear material. The major objective of this study was to provide consultation to NYSDEC and the US NRC to assist NYSDEC in determining if broad-based licensed facilities with multiple emission points were in compliance with NYCRR Part 380. Under this contract, BNL would evaluate a multiple emission point facility, identified by NYSDEC, as a case study. The review would be a nonbinding evaluation of the facility to determine likely dispersion characteristics, compliance with specified release limits, and implementation of the ALARA philosophy regarding effluent release practices. From the data collected, guidance as to areas of future investigation and the impact of new federal regulations were to be developed. Reported here is the case study for the University of Rochester, Strong Memorial Medical Center and Riverside Campus

Colloidal drug delivery system: amplify the ocular delivery.

Science.gov (United States)

Ali, Javed; Fazil, Mohd; Qumbar, Mohd; Khan, Nazia; Ali, Asgar

2016-01-01

The ocular perceivers are the most voluntarily accessible organs in terms of location in the body, yet drug distribution to these tissues is one of the most intriguing and challenging endeavors and problematic to the pharmaceutical scientist. The most of ocular diseases are treated with topical application of conventional formulation, i.e. solutions, suspensions and ointment. Typically on installation of these conventional formulations, only <5% of the applied dose penetrates the cornea and reaches intraocular tissues, while a major fraction of the instilled dose is wastage due to the presence of many ocular barriers like external barriers, rapid loss of the instilled solution from the precorneal area and nasolacrimal drainage system. Systemic absorption caused systemic side effects varying from mild to life-threatening events. The main objective of this review is to explore the role of colloidal delivery of drug to minimize the drawbacks associated with them. This review provides an insight into the various constraints associated with ocular drug delivery, summarizes recent findings and applications of colloidal delivery systems, i.e. nanoparticles, nanosuspensions, liposomes, niosomes, dendrimers and contact lenses containing nanoparticles have the capacity to distribute ocular drugs to categorical target sites and hold promise to revolutionize the therapy of many ocular perceiver diseases and minimized the circumscription of conventional delivery. Form the basis of literature review, it has been found that the novel delivery system have greater impact to maximize ocular drug absorption, and minimize systemic absorption and side effects.

A genomic point-of-view on environmental factors influencing the human brain methylome.

Science.gov (United States)

LaSalle, Janine M

2011-07-01

The etiologic paradigm of complex human disorders such as autism is that genetic and environmental risk factors are independent and additive, but the interactive effects at the epigenetic interface are largely ignored. Genomic technologies have radically changed perspective on the human genome and how the epigenetic interface may impact complex human disorders. Here, I review recent genomic, environmental, and epigenetic findings that suggest a new paradigm of "integrative genomics" in which genetic variation in genomic size may be impacted by dietary and environmental factors that influence the genomic saturation of DNA methylation. Human genomes are highly repetitive, but the interface of large-scale genomic differences with environmental factors that alter the DNA methylome such as dietary folate is under-explored. In addition to obvious direct effects of some environmental toxins on the genome by causing chromosomal breaks, non-mutagenic toxin exposures correlate with DNA hypomethylation that can lead to rearrangements between repeats or increased retrotransposition. Since human neurodevelopment appears to be particularly sensitive to alterations in epigenetic pathways, a further focus will be on how developing neurons may be particularly impacted by even subtle alterations to DNA methylation and proposing new directions towards understanding the quixotic etiology of autism by integrative genomic approaches.

Neonatal outcomes and operative vaginal delivery versus cesarean delivery.

LENUS (Irish Health Repository)

Contag, Stephen A

2010-06-01

We compared outcomes for neonates with forceps-assisted, vacuum-assisted, or cesarean delivery in the second stage of labor. This is a secondary analysis of a randomized trial in laboring, low-risk, nulliparous women at >or=36 weeks\\' gestation. Neonatal outcomes after use of forceps, vacuum, and cesarean were compared among women in the second stage of labor at station +1 or below (thirds scale) for failure of descent or nonreassuring fetal status. Nine hundred ninety women were included in this analysis: 549 (55%) with an indication for delivery of failure of descent and 441 (45%) for a nonreassuring fetal status. Umbilical cord gases were available for 87% of neonates. We found no differences in the base excess (P = 0.35 and 0.78 for failure of descent and nonreassuring fetal status) or frequencies of pH below 7.0 (P = 0.73 and 0.34 for failure of descent and nonreassuring fetal status) among the three delivery methods. Birth outcomes and umbilical cord blood gas values were similar for those neonates with a forceps-assisted, vacuum-assisted, or cesarean delivery in the second stage of labor. The occurrence of significant fetal acidemia was not different among the three delivery methods regardless of the indication.

Assisted delivery with forceps

Science.gov (United States)

... page: //medlineplus.gov/ency/patientinstructions/000509.htm Assisted delivery with forceps To use the sharing features on ... called vacuum assisted delivery . When is a Forceps Delivery Needed? Even after your cervix is fully dilated ( ...

TRANSDERMAL DRUG DELIVERY SYSTEM: REVIEW

OpenAIRE

Vishvakarama Prabhakar; Agarwal Shivendra; Sharma Ritika; Saurabh Sharma

2012-01-01

Various new technologies have been developed for the transdermal delivery of some important drugs. Today about 74% of drugs are taken orally and are found not to be as effective as desired. To improve such characters transdermal drug delivery system was emerged. Drug delivery through the skin to achieve a systemic effect of a drug is commonly known as transdermal drug delivery and differs from traditional topical drug delivery. Transdermal drug delivery systems (TDDS) are dosage forms involve...

Ethical issues in cesarean delivery.

Science.gov (United States)

Chervenak, Frank A; McCullough, Laurence B

2017-08-01

Cesarean delivery is the most common and important surgical intervention in obstetric practice. Ethics provides essential guidance to obstetricians for offering, recommending, recommending against, and performing cesarean delivery. This chapter provides an ethical framework based on the professional responsibility model of obstetric ethics. This framework is then used to address two especially ethically challenging clinical topics in cesarean delivery: patient-choice cesarean delivery and trial of labor after cesarean delivery. This chapter emphasizes a preventive ethics approach, designed to prevent ethical conflict in clinical practice. To achieve this goal, a preventive ethics approach uses the informed consent process to offer cesarean delivery as a medically reasonable alternative to vaginal delivery, to recommend cesarean delivery, and to recommend against cesarean delivery. The limited role of shared decision making is also described. The professional responsibility model of obstetric ethics guides this multi-faceted preventive ethics approach. Copyright © 2017. Published by Elsevier Ltd.

Environmental Morale and Motivation

OpenAIRE

Frey, Bruno S; Stutzer, Alois

2006-01-01

This chapter discusses the role of environmental morale and environmental motivation in individual behavior from the point of view of economics and psychology. It deals with the fundamental public good problem, and presents empirical (laboratory and field) evidence on how the cooperation problem can be overcome. Four different theoretical approaches are distinguished according to how individuals� underlying environmental motivation is modeled. Specifically, we look at the interaction betwee...

Delivery of proteins to mammalian cells via gold nanoparticle mediated laser transfection

International Nuclear Information System (INIS)

Heinemann, D; Kalies, S; Schomaker, M; Ertmer, W; Meyer, H; Ripken, T; Murua Escobar, H

2014-01-01

Nanoparticle laser interactions are in widespread use in cell manipulation. In particular, molecular medicine needs techniques for the directed delivery of molecules into mammalian cells. Proteins are the final mediator of most cellular cascades. However, despite several methodical approaches, the efficient delivery of proteins to cells remains challenging. This paper presents a new protein transfection technique via laser scanning of cells previously incubated with gold nanoparticles. The laser-induced plasmonic effects on the gold nanoparticles cause a transient permeabilization of the cellular membrane, allowing proteins to enter the cell. Applying this technique, it was possible to deliver green fluorescent protein into mammalian cells with an efficiency of 43%, maintaining a high level of cell viability. Furthermore, a functional delivery of Caspase 3, an apoptosis mediating protein, was demonstrated and evaluated in several cellular assays. Compared to conventional protein transfection techniques such as microinjection, the methodical approach presented here enables high-throughput transfection of about 10 000 cells per second. Moreover, a well-defined point in time of delivery is guaranteed by gold nanoparticle mediated laser transfection, allowing the detailed temporal analysis of cellular pathways and protein trafficking. (papers)

The U.S. Twin Delivery Volume and Association with Cesarean Delivery Rates: A Hospital-Level Analysis.

Science.gov (United States)

Easter, Sarah Rae; Robinson, Julian N; Carusi, Daniela; Little, Sarah E

2018-03-01

 The objective of this study was to test whether hospitals experienced in twin delivery have lower rates of cesarean delivery for twins.  We divided obstetric hospitals in the 2011 National Inpatient Sample by quartile of annual twin deliveries and compared twin cesarean delivery rates between hospitals with weighted linear regression. We used Pearson's coefficients to correlate a hospital's twin cesarean delivery rate to its overall cesarean delivery and vaginal birth after cesarean (VBAC) rates.  Annual twin delivery volume ranged from 1 to 506 across the 547 analyzed hospitals with a median of 10 and mode of 3. Adjusted rates of cesarean delivery were independent of delivery volume with a rate of 75.5 versus 74.8% in the lowest and highest volume hospitals ( p  = 0.09 across quartiles). A hospital's cesarean delivery rate for twins moderately correlated with the overall cesarean rate ( r  = 0.52, p  < 0.01) and inversely correlated with VBAC rate ( r  =  - 0.42, p  < 0.01).  Most U.S. obstetrical units perform a low volume of twin deliveries with no decrease in cesarean delivery rates at higher volume hospitals. Twin cesarean delivery rates correlate with other obstetric parameters such as singleton cesarean delivery and VBAC rates suggesting twin cesarean delivery rate is more closely related to a hospital's general obstetric practice than its twin delivery volume. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Information access, income distribution, and the Environmental Kuznets Curve

Energy Technology Data Exchange (ETDEWEB)

Bimonte, Salvatore [Department of Political Economy, University of Siena, Piazza S. Francesco 7, 53100 Siena (Italy)

2002-04-01

Recent empirical studies have tested the hypothesis of an Environmental Kuznets Curve (EKC) focusing primarily on the relationship between per capita income and certain types of pollutant emissions. Given the stock-nature of many pollution problems, emissions only partially account for the environmental impacts. Moreover, almost all of the studies have given consideration to little more than income levels as explanatory variables. This paper empirically tests the hypothesis of the EKC existence for a stock-sensitive indicator, that is, the percentage of protected area (PA) within national territory. It does theorize that economic growth is a necessary condition in order to better address environmental issues. But it also stresses that other variables (income distribution, education, information accessibility) may play a fundamental role in determining environmental quality. Contrary to other studies that mainly focus on the calculation of the income level corresponding to the transition point, this paper is more concerned with the calculation of environmental quality corresponding to that transition point, that is, the minimum level of environmental quality that a country is willing to accept. This paper highlights the idea that if the transition point is determined primarily by income level, social policies determine the level of environmental quality corresponding to that point.

Information access, income distribution, and the Environmental Kuznets Curve

International Nuclear Information System (INIS)

Bimonte, Salvatore

2002-01-01

Recent empirical studies have tested the hypothesis of an Environmental Kuznets Curve (EKC) focusing primarily on the relationship between per capita income and certain types of pollutant emissions. Given the stock-nature of many pollution problems, emissions only partially account for the environmental impacts. Moreover, almost all of the studies have given consideration to little more than income levels as explanatory variables. This paper empirically tests the hypothesis of the EKC existence for a stock-sensitive indicator, that is, the percentage of protected area (PA) within national territory. It does theorize that economic growth is a necessary condition in order to better address environmental issues. But it also stresses that other variables (income distribution, education, information accessibility) may play a fundamental role in determining environmental quality. Contrary to other studies that mainly focus on the calculation of the income level corresponding to the transition point, this paper is more concerned with the calculation of environmental quality corresponding to that transition point, that is, the minimum level of environmental quality that a country is willing to accept. This paper highlights the idea that if the transition point is determined primarily by income level, social policies determine the level of environmental quality corresponding to that point

Fluoride loaded polymeric nanoparticles for dental delivery.

Science.gov (United States)

Nguyen, Sanko; Escudero, Carlos; Sediqi, Nadia; Smistad, Gro; Hiorth, Marianne

2017-06-15

The overall aim of the present paper was to develop fluoride loaded nanoparticles based on the biopolymers chitosan, pectin, and alginate, for use in dental delivery. First, the preparation of nanoparticles in the presence of sodium fluoride (NaF) as the active ingredient by ionic gelation was investigated followed by an evaluation of their drug entrapment and release properties. Chitosan formed stable, spherical, and monodisperse nanoparticles in the presence of NaF and tripolyphoshate as the crosslinker, whereas alginate and pectin were not able to form any definite nanostructures in similar conditions. The fluoride loading capacity was found to be 33-113ppm, and the entrapment efficiency 3.6-6.2% for chitosan nanoparticles prepared in 0.2-0.4% (w/w) NaF, respectively. A steady increase in the fluoride release was observed for chitosan nanoparticles prepared in 0.2% NaF both in pH5 and 7 until it reached a maximum at time point 4h and maintained at this level for at least 24h. Similar profiles were observed for formulations prepared in 0.4% NaF; however the fluoride was released at a higher level at pH5. The low concentration, but continuous delivery of fluoride from the chitosan nanoparticles, with possible expedited release in acidic environment, makes these formulations highly promising as dental delivery systems in the protection against caries development. Copyright © 2017 Elsevier B.V. All rights reserved.

Normal Range of Head-to-body Delivery Interval by Two-step Delivery

Directory of Open Access Journals (Sweden)

Hong-Yu Zhang

2016-01-01

Conclusions: The average time of head-to-body delivery interval was longer than 60 s by two-step delivery. Majority shoulders were delivered at the first contraction. Majority shoulders emerged from perineum rather from under pubic arch. The routine one-step method of shoulder delivery where the downward force applied is not necessary and is not the right direction. Baby's breath, making faces, sucking, bubble from noses and mouth, and the light blue color of the faces, all those signs during shoulder delivery indicated a normal live birth.

Levodopa delivery systems: advancements in delivery of the gold standard.

Science.gov (United States)

Ngwuluka, Ndidi; Pillay, Viness; Du Toit, Lisa C; Ndesendo, Valence; Choonara, Yahya; Modi, Girish; Naidoo, Dinesh

2010-02-01

Despite the fact that Parkinson's disease (PD) was discovered almost 200 years ago, its treatment and management remain immense challenges because progressive loss of dopaminergic nigral neurons, motor complications experienced by the patients as the disease progresses and drawbacks of pharmacotherapeutic management still persist. Various therapeutic agents have been used in the management of PD, including levodopa (l-DOPA), selegiline, amantadine, bromocriptine, entacapone, pramipexole dihydrochloride and more recently istradefylline and rasagiline. Of all agents, l-DOPA although the oldest, remains the most effective. l-DOPA is easier to administer, better tolerated, less expensive and is required by almost all PD patients. However, l-DOPA's efficacy in advanced PD is significantly reduced due to metabolism, subsequent low bioavailability and irregular fluctuations in its plasma levels. Significant strides have been made to improve the delivery of l-DOPA in order to enhance its bioavailability and reduce plasma fluctuations as well as motor complications experienced by patients purportedly resulting from pulsatile stimulation of the striatal dopamine receptors. Drug delivery systems that have been instituted for the delivery of l-DOPA include immediate release formulations, liquid formulations, dispersible tablets, controlled release formulations, dual-release formulations, microspheres, infusion and transdermal delivery, among others. In this review, the l-DOPA-loaded drug delivery systems developed over the past three decades are elaborated. The ultimate aim was to assess critically the attempts made thus far directed at improving l-DOPA absorption, bioavailability and maintenance of constant plasma concentrations, including the drug delivery technologies implicated. This review highlights the fact that neuropharmaceutics is at a precipice, which is expected to spur investigators to take that leap to enable the generation of innovative delivery systems for the

Elsam's environmental report 1997

International Nuclear Information System (INIS)

1999-01-01

The purpose of this environmental report from ELSAM is to inform the consumers of the environmental impacts of power production. I/S ELSAM is the cooperation of the electricity and heat power plants in Funen and Jutland. The report covers issues like declaration of power from an environmental point of view, emission of SO 2 , CO 2 1 and NO x , energy from biomass, and key figures from the power plants. (SM)

Elsam environmental report 1998

International Nuclear Information System (INIS)

1999-01-01

The purpose of this environmental report from ELSAM is to inform the consumers of the environmental impacts of power production. I/S ELSAM is the cooperation of the electricity and heat power plants in Funen and Jutland. The report covers issues like declaration of power from an environmental point of view, emission of SO 2 , CO 2 1 and NO x , energy from biomass, and key figures from the power plants. (SM)

Reduction of treatment delivery variances with a computer-controlled treatment delivery system

International Nuclear Information System (INIS)

Fraass, B.A.; Lash, K.L.; Matrone, G.M.; Lichter, A.S.

1997-01-01

Purpose: To analyze treatment delivery variances for 3-D conformal therapy performed at various levels of treatment delivery automation, ranging from manual field setup to virtually complete computer-controlled treatment delivery using a computer-controlled conformal radiotherapy system. Materials and Methods: All external beam treatments performed in our department during six months of 1996 were analyzed to study treatment delivery variances versus treatment complexity. Treatments for 505 patients (40,641 individual treatment ports) on four treatment machines were studied. All treatment variances noted by treatment therapists or quality assurance reviews (39 in all) were analyzed. Machines 'M1' (CLinac (6(100))) and 'M2' (CLinac 1800) were operated in a standard manual setup mode, with no record and verify system (R/V). Machines 'M3' (CLinac 2100CD/MLC) and ''M4'' (MM50 racetrack microtron system with MLC) treated patients under the control of a computer-controlled conformal radiotherapy system (CCRS) which 1) downloads the treatment delivery plan from the planning system, 2) performs some (or all) of the machine set-up and treatment delivery for each field, 3) monitors treatment delivery, 4) records all treatment parameters, and 5) notes exceptions to the electronically-prescribed plan. Complete external computer control is not available on M3, so it uses as many CCRS features as possible, while M4 operates completely under CCRS control and performs semi-automated and automated multi-segment intensity modulated treatments. Analysis of treatment complexity was based on numbers of fields, individual segments (ports), non-axial and non-coplanar plans, multi-segment intensity modulation, and pseudo-isocentric treatments (and other plans with computer-controlled table motions). Treatment delivery time was obtained from the computerized scheduling system (for manual treatments) or from CCRS system logs. Treatment therapists rotate among the machines, so this analysis

Abandoned Uranium Mine (AUM) Points, Navajo Nation, 2016, US EPA Region 9

Data.gov (United States)

U.S. Environmental Protection Agency — This GIS dataset contains point features of all Abandoned Uranium Mines (AUMs) on or within one mile of the Navajo Nation. Points are centroids developed from the...

Education for climate changes, environmental health and environmental justice

International Nuclear Information System (INIS)

Hens, L.; Stoyanov, S.

2013-01-01

Full text: The climates changes-health effects-environmental justice nexus is analyzed. The complex issue of climate changes needs to be approached from an interdisciplinary point of view. The nature of the problem necessitates dealing with scientific uncertainty. The health effects caused by climate changes are described and analyzed from a twofold inequalities point of view: health inequalities between rich and poor within countries, and inequalities between northern and southern countries. It is shown thai although the emission of greenhouse gasses is to a large extent caused by the industrialized countries, the effects, including the health effects, will merely impact the South. On the other hand, the southern countries have the highest potential to respond to and offer sustainable energy solutions to counteract climate changes. These inequalities are at the basis to call for environmental justice, of which climate justice is part. This movement calls for diversification of ecologists and their subject of study, more attention for urban ecology, more comprehensive human ecological analyses of complex environmental issues and more participation of stakeholders in the debate and the solution options. The movement advocates a more inclusive ecology targeted to management, sodo-ecological restoration, and comprehensive policies. The fundamental aspects of complexity, inter-disciplinary approaches, uncertainty, and social and natural inequalities should be core issues in environmental health programs. Training on these issues for muitidisciplinary groups of participants necessitates innovative approaches including self-directed, collaborative, and problem oriented learning in which tacit knowledge is important. It is advocated that quality assessments of environmental health programs should take these elements into account. key words: environmental justice, climate changes, sustainable energy solutions

Project W-314 phase I environmental permits and approvals plan

International Nuclear Information System (INIS)

TOLLEFSON, K.S.

1999-01-01

This document describes the range of environmental actions, including required permits and other agency approvals, for Project W-314 activities in the Hanford Site's Tank Waste Remediation System. This document outlines alternative approaches to satisfying applicable environmental standards, and describes selected strategies for acquiring permits and other approvals needed for waste feed delivery to proceed. This document also includes estimated costs and schedule to obtain the required permits and approvals based on the selected strategy. It also provides estimated costs for environmental support during design and construction based on the preliminary project schedule provided

Risk factors for cesarean delivery and adverse neonatal outcome in twin pregnancies attempting vaginal delivery.

Science.gov (United States)

Schachter-Safrai, Natali; Karavani, Gilad; Haj-Yahya, Rani; Ofek Shlomai, Noa; Porat, Shay

2018-02-24

Twin vaginal delivery presents a unique clinical challenge for obstetricians. The Twin Birth Study demonstrated the safety of planned vaginal delivery regarding neonatal outcomes. However, that study lacked a description of the risk factors associated with and the outcome of unplanned cesarean section. The aim of this study is to identify potential risk factors for cesarean section and delivery related neonatal morbidity and mortality in women with twin pregnancy attempting vaginal delivery. A retrospective cohort study including 1070 women with twin pregnancy that underwent a trial of labor between 2003 and 2015. The study population was divided according to the mode of delivery: vaginal delivery, combined vaginal-cesarean and intrapartum cesarean delivery of both twins. Several risk factors and neonatal outcomes were examined by both univariate analysis and multinomial logistic regression analysis. The rate of vaginal delivery of both twins was 88.3%, whereas the rates of combined vaginal cesarean and unplanned cesarean delivery were 4.6% and 7.1%, respectively. Nulliparity and nonvertex presentation of twin B were found to be independently associated with cesarean delivery for both twins. Additionally, nonvertex presentation of twin B was independently associated with combined vaginal-cesarean delivery. The proportion of neonates with Apgar score cesarean group compared with those delivered by the vaginal route alone. Nulliparity and nonvertex presentation of twin B were found to be associated with intrapartum cesarean delivery in twin pregnancies. © 2018 Nordic Federation of Societies of Obstetrics and Gynecology.

Beam delivery system with a non-digitized diffractive beam splitter for laser-drilling of silicon

Science.gov (United States)

Amako, J.; Fujii, E.

2016-02-01

We report a beam-delivery system consisting of a non-digitized diffractive beam splitter and a Fourier transform lens. The system is applied to the deep-drilling of silicon using a nanosecond pulse laser in the manufacture of inkjet printer heads. In this process, a circularly polarized pulse beam is divided into an array of uniform beams, which are then delivered precisely to the process points. To meet these requirements, the splitter was designed to be polarization-independent with an efficiency>95%. The optical elements were assembled so as to allow the fine tuning of the effective overall focal length by adjusting the wavefront curvature of the beam. Using the system, a beam alignment accuracy ofbeam array and the throughput was substantially improved (10,000 points on a silicon wafer drilled in ~1 min). This beam-delivery scheme works for a variety of laser applications that require parallel processing.

Energy efficient structure-free data aggregation and delivery in WSN

Directory of Open Access Journals (Sweden)

Prabhudutta Mohanty

2016-11-01

Full Text Available In Wireless Sensor Networks (WSNs, the energy consumption due to the sensed data transmission is more than processing data locally within the sensor node. The data aggregation is one of the techniques to conserve energy by eliminating the redundant data transmission in dense WSNs. In this paper, we propose an energy efficient structure-free data aggregation and delivery (ESDAD protocol, which aggregates the redundant data in the intermediate nodes. In the proposed protocol, waiting time for packets at each intermediate node is calculated very sensibly so that data can be aggregated efficiently in the routing path. The sensed data packets are transmitted judicially to the aggregation point for data aggregation. The ESDAD protocol computes a cost function for structure-free, next-hop node selection and performs near source data aggregation. The buffer of each node is partitioned to maintain different types of flows for fair and efficient data delivery. The transmission rates of the sources and intermediate nodes are adjusted during congestion. The performance of the proposed protocol is evaluated through extensive simulations. The simulation results reveal that it outperforms the existing structure-free protocols in terms of energy efficiency, reliability and on-time delivery ratio.

Environmental medicine

International Nuclear Information System (INIS)

Steneberg, A.

1996-01-01

'Environmental medicine' deals with the manifold health problems from environmental factors of chemical, physical and psychosocial origin that are possible or have been observed. The book gives insight into the current state of knowledge of environmental medicine institutions, possibilities of diagnosis and therapeutic methods. It offers a systematic overview of pollutant sources and pollutant effects and points out, inter alia, syndromes that are discussed in connection with environmental factors: not only allergies and carcinogenous diseases but also symptom complexes that are hard to diagnose by ordinary methods such as the sick-building syndrome, multiple sensitivity to chemicals, electrosensitivity, amalgam intoxications, disorders due to wood preservatives and fungal diseases. The lingering course of a disease and a set of symptoms varying from one patient to another are the rule, not the exception, because environmental diseases are due above all to the chronic uptake of low pollutant doses (orig./MG) [de

THE WEB SERVICE PROTOTYPE ON DELIVERY SYSTEM IN THE IMPLEMENTATION OF ENTERPRISE SERVICE BUS

Directory of Open Access Journals (Sweden)

Ghifari Munawar

2017-04-01

Full Text Available The main component of the logistics system is a delivery goods system. It has an enormous role in managing the entire historical shipment data from the start point (origin to the end of delivery (destination. This research aims to implement the Enterprise Service Bus (ESB on delivery systems as a middleware in the integration data process. ESB technology used in this research is NServiceBus. The stages of research using a prototype model to develop a web service that suits with theirs needs. Testing is done by tested two aspects of the exchange messages; the performance aspect and the aspect of independence. The test results show that the performance of the web service with the ESB application is better than the non-ESB user and Web services developed to have a good level of independence (loosely coupling.

Selecting Features Of A Web Platform To Enhance Course Delivery

OpenAIRE

Karen A. Berger; Martin T. Topol

2011-01-01

This paper reviews key features of popular Web platforms used for course delivery. Institutions of higher education have rushed to adopt these platforms for several reasons. From the point of view of the educator, the most important reason is to enhance the classroom experience (real or virtual). Classroom experiences can benefit from a continuous stream of discourse made possible by the communications tools available in the web platforms designed for educational application. In addition, web...

MRI in ocular drug delivery

OpenAIRE

Li, S. Kevin; Lizak, Martin J.; Jeong, Eun-Kee

2008-01-01

Conventional pharmacokinetic methods for studying ocular drug delivery are invasive and cannot be conveniently applied to humans. The advancement of MRI technology has provided new opportunities in ocular drug-delivery research. MRI provides a means to non-invasively and continuously monitor ocular drug-delivery systems with a contrast agent or compound labeled with a contrast agent. It is a useful technique in pharmacokinetic studies, evaluation of drug-delivery methods, and drug-delivery de...

Vacuum-assisted delivery

Science.gov (United States)

... medlineplus.gov/ency/patientinstructions/000514.htm Vacuum-assisted delivery To use the sharing features on this page, ... through the birth canal. When is Vacuum-assisted Delivery Needed? Even after your cervix is fully dilated ( ...

Computer-controlled 3-D treatment delivery

International Nuclear Information System (INIS)

Fraass, Benedick A.

1995-01-01

Purpose/Objective: This course will describe the use of computer-controlled treatment delivery techniques for treatment of patients with sophisticated conformal therapy. In particular, research and implementation issues related to clinical use of computer-controlled conformal radiation therapy (CCRT) techniques will be discussed. The possible/potential advantages of CCRT techniques will be highlighted using results from clinical 3-D planning studies. Materials and Methods: In recent years, 3-D treatment planning has been used to develop and implement 3-D conformal therapy treatment techniques, and studies based on these conformal treatments have begun to show the promise of conformal therapy. This work has been followed by the development of commercially-available multileaf collimator and computer control systems for treatment machines. Using these (and other) CCRT devices, various centers are beginning to clinically use complex computer-controlled treatments. Both research and clinical CCRT treatment techniques will be discussed in this presentation. General concepts and requirements for CCRT will be mentioned. Developmental and clinical experience with CCRT techniques from a number of centers will be utilized. Results: Treatment planning, treatment preparation and treatment delivery must be approached in an integrated fashion in order to clinically implement CCRT treatment techniques, and the entire process will be discussed. Various CCRT treatment methodologies will be reviewed from operational, dosimetric, and technical points of view. The discussion will concentrate on CCRT techniques which are likely to see rather wide dissemination over the next several years, including particularly the use of multileaf collimators (MLC), dynamic and segmental conformal therapy, conformal field shaping, and other related techniques. More advanced CCRT techniques, such as the use of individualized intensity modulation of beams or segments, and the use of computer

Soil redistribution and nutrient delivery in a Mediterranean rain-fed agro-ecosystem with different crops and management: environmental and economic aspects

Science.gov (United States)

López-Vicente, Manuel; Álvarez, Sara

2017-04-01

Mediterranean agro-ecosystems are characterised by fragmented fields and patched vegetation. This shape governs the spatial patterns of water, soil and nutrient redistribution. Rainfall parameters, human infrastructures, crop management, support practices, and land use changes (set aside crops, land abandonment) control the magnitude of these processes. Under rain-fed water supply conditions, runoff generation and soil water content are two important factors in determining crop yield. Soil erosion and nutrient delivery are two of the factors which limit crop yield and thus, the gross earning of the landowner. In hilly landscapes, farmers usually supply extra soil to fill in the ephemeral gullies, and nutrient replenishment with fertilizers is a common practice. The aim of this study is to evaluate the environmental (runoff yield, soil erosion and nutrient delivery) and economic (replenishment of soil and nutrient losses with new soil and fertilizers) consequences of different conventional and conservative practices (fallow/crop rotation, cover crops, land abandonment, buffer strips) in a Mediterranean rain-fed agro-ecosystem (27 ha) with vineyards, cereal crops, cultivated and abandoned olive orchards, several trails and patches of natural vegetation. The five winter cereal fields (wheat and barley) follow fallow/crop rotation. The four vineyards are devoted to the Garnacha variety: one planted in 2007 with white wine grapes, and three planted in 2008 with red wine grapes. The inter-crop strips are managed with a mixture of plant species as cover crop (CC), including: i) spontaneous vegetation, and ii) plantation of common sainfoin (Onobrychis viciifolia). The maintenance of the CC includes one mowing pass at the end of spring, between May and June. The appearance and development of ephemeral gullies and the deposition of soil at the bottom of the hillslope are two of the main concerns of the landowners. In some places, the accumulation of soil complicates grape

Stimuli-Responsive Polymeric Systems for Controlled Protein and Peptide Delivery: Future Implications for Ocular Delivery.

Science.gov (United States)

Mahlumba, Pakama; Choonara, Yahya E; Kumar, Pradeep; du Toit, Lisa C; Pillay, Viness

2016-07-30

Therapeutic proteins and peptides have become notable in the drug delivery arena for their compatibility with the human body as well as their high potency. However, their biocompatibility and high potency does not negate the existence of challenges resulting from physicochemical properties of proteins and peptides, including large size, short half-life, capability to provoke immune responses and susceptibility to degradation. Various delivery routes and delivery systems have been utilized to improve bioavailability, patient acceptability and reduce biodegradation. The ocular route remains of great interest, particularly for responsive delivery of macromolecules due to the anatomy and physiology of the eye that makes it a sensitive and complex environment. Research in this field is slowly gaining attention as this could be the breakthrough in ocular drug delivery of macromolecules. This work reviews stimuli-responsive polymeric delivery systems, their use in the delivery of therapeutic proteins and peptides as well as examples of proteins and peptides used in the treatment of ocular disorders. Stimuli reviewed include pH, temperature, enzymes, light, ultrasound and magnetic field. In addition, it discusses the current progress in responsive ocular drug delivery. Furthermore, it explores future prospects in the use of stimuli-responsive polymers for ocular delivery of proteins and peptides. Stimuli-responsive polymers offer great potential in improving the delivery of ocular therapeutics, therefore there is a need to consider them in order to guarantee a local, sustained and ideal delivery of ocular proteins and peptides, evading tissue invasion and systemic side-effects.

Environmental Balance 2006

International Nuclear Information System (INIS)

2006-01-01

It is the intention of the Dutch government to evaluate and assess every year the quality of the environmental policy as has been executed in the previous year. Also in this State of the Environment attention is paid to the actual development of the environmental quality and accompanying changes in ecosystems and public health related to societal activities and the effect of the environmental policy. Different points of view of the policy are dealt with, in particular with regard to target groups, subjects, compartments and areas. Based on the results of the evaluation the targets can be adjusted. In this report special attention is paid to the Dutch environmental policy in the European context [nl

IP over optical multicasting for large-scale video delivery

Science.gov (United States)

Jin, Yaohui; Hu, Weisheng; Sun, Weiqiang; Guo, Wei

2007-11-01

In the IPTV systems, multicasting will play a crucial role in the delivery of high-quality video services, which can significantly improve bandwidth efficiency. However, the scalability and the signal quality of current IPTV can barely compete with the existing broadcast digital TV systems since it is difficult to implement large-scale multicasting with end-to-end guaranteed quality of service (QoS) in packet-switched IP network. China 3TNet project aimed to build a high performance broadband trial network to support large-scale concurrent streaming media and interactive multimedia services. The innovative idea of 3TNet is that an automatic switched optical networks (ASON) with the capability of dynamic point-to-multipoint (P2MP) connections replaces the conventional IP multicasting network in the transport core, while the edge remains an IP multicasting network. In this paper, we will introduce the network architecture and discuss challenges in such IP over Optical multicasting for video delivery.

76 FR 73721 - Nine Mile Point Nuclear Station, LLC, Nine Mile Point Nuclear Station, Unit No. 2, Environmental...

Science.gov (United States)

2011-11-29

.... Solid radioactive waste streams include filter sludge, spent ion exchange resin, and dry active waste... Environmental Impact of Transportation of Fuel and Waste to and from One Light-Water-Cooled Nuclear Power... facilities. NMP2 uses a boiling-water reactor and a nuclear steam supply system designed by General Electric...

Gender preference between traditional and PowerPoint methods of teaching gross anatomy.

Science.gov (United States)

Nuhu, Saleh; Adamu, Lawan Hassan; Buba, Mohammed Alhaji; Garba, Sani Hyedima; Dalori, Babagana Mohammed; Yusuf, Ashiru Hassan

2018-01-01

Teaching and learning process is increasingly metamorphosing from the traditional chalk and talk to the modern dynamism in the information and communication technology. Medical education is no exception to this dynamism more especially in the teaching of gross anatomy, which serves as one of the bases of understanding the human structure. This study was conducted to determine the gender preference of preclinical medical students on the use of traditional (chalk and talk) and PowerPoint presentation in the teaching of gross anatomy. This was cross-sectional and prospective study, which was conducted among preclinical medical students in the University of Maiduguri, Nigeria. Using simple random techniques, a questionnaire was circulated among 280 medical students, where 247 students filled the questionnaire appropriately. The data obtained was analyzed using SPSS version 20 (IBM Corporation, Armonk, NY, USA) to find the method preferred by the students among other things. Majority of the preclinical medical students in the University of Maiduguri preferred PowerPoint method in the teaching of gross anatomy over the conventional methods. The Cronbach alpha value of 0.76 was obtained which is an acceptable level of internal consistency. A statistically significant association was found between gender and preferred method of lecture delivery on the clarity of lecture content where females prefer the conventional method of lecture delivery whereas males prefer the PowerPoint method, On the reproducibility of text and diagram, females prefer PowerPoint method of teaching gross anatomy while males prefer the conventional method of teaching gross anatomy. There are gender preferences with regard to clarity of lecture contents and reproducibility of text and diagram. It was also revealed from this study that majority of the preclinical medical students in the University of Maiduguri prefer PowerPoint presentation over the traditional chalk and talk method in most of the

Supervision of compliance with the environmental legislation especially from the point of view of the Environmental Protection Act; Ympaeristoelainsaeaedaennoen laillisuusvalvonta - erityisesti ympaeristoensuojelulain naekoekulmasta

Energy Technology Data Exchange (ETDEWEB)

Pennanen, J. (ed.)

2006-07-01

The topic of the publication is the supervision of compliance with the environmental legislation. The publication presents the environmental enforcement bodies and the practical use of administrative sanctions. The environmental authorities may use voluntary or administrative means and also make an official report of an offence. The publication is aimed at the environmental authorities, inspectors and other authorities. The appendices show models for documents in supervision. (orig.)

Conference on Environmental Data Management

CERN Document Server

Oppenheimer, Dorothy; Brogden, William; Environmental Data Management

1976-01-01

Throughout the world a staggering amount of resources have been used to obtain billions of environmental data points. Some, such as meteorological data, have been organized for weather map display where many thousands of data points are synthesized in one compressed map. Most environmental data, however, are still widely scattered and generally not used for a systems approach, but only for the purpose for which they were originally taken. These data are contained in relatively small computer programs, research files, government and industrial reports, etc. This Conference was called to bring together some of the world's leaders from research centers and government agencies, and others concerned with environmental data management. The purpose of the Conference was to organize discussion on the scope of world environmental data, its present form and documentation, and whether a systematic approach to a total system is feasible now or in the future. This same subject permeated indirectly the Stockholm Conference...

Emerging Frontiers in Drug Delivery.

Science.gov (United States)

Tibbitt, Mark W; Dahlman, James E; Langer, Robert

2016-01-27

Medicine relies on the use of pharmacologically active agents (drugs) to manage and treat disease. However, drugs are not inherently effective; the benefit of a drug is directly related to the manner by which it is administered or delivered. Drug delivery can affect drug pharmacokinetics, absorption, distribution, metabolism, duration of therapeutic effect, excretion, and toxicity. As new therapeutics (e.g., biologics) are being developed, there is an accompanying need for improved chemistries and materials to deliver them to the target site in the body, at a therapeutic concentration, and for the required period of time. In this Perspective, we provide an historical overview of drug delivery and controlled release followed by highlights of four emerging areas in the field of drug delivery: systemic RNA delivery, drug delivery for localized therapy, oral drug delivery systems, and biologic drug delivery systems. In each case, we present the barriers to effective drug delivery as well as chemical and materials advances that are enabling the field to overcome these hurdles for clinical impact.

CSF and blood oxytocin concentration changes following intranasal delivery in macaque.

Directory of Open Access Journals (Sweden)

Olga Dal Monte

Full Text Available Oxytocin (OT in the central nervous system (CNS influences social cognition and behavior, making it a candidate for treating clinical disorders such as schizophrenia and autism. Intranasal administration has been proposed as a possible route of delivery to the CNS for molecules like OT. While intranasal administration of OT influences social cognition and behavior, it is not well established whether this is an effective means for delivering OT to CNS targets. We administered OT or its vehicle (saline to 15 primates (Macaca mulatta, using either intranasal spray or a nebulizer, and measured OT concentration changes in the cerebral spinal fluid (CSF and in blood. All subjects received both delivery methods and both drug conditions. Baseline samples of blood and CSF were taken immediately before drug administration. Blood was collected every 10 minutes after administration for 40 minutes and CSF was collected once post-delivery, at the 40 minutes time point. We found that intranasal administration of exogenous OT increased concentrations in both CSF and plasma compared to saline. Both delivery methods resulted in similar elevations of OT concentration in CSF, while the changes in plasma OT concentration were greater after nasal spray compared to nebulizer. In conclusion our study provides evidence that both nebulizer and nasal spray OT administration can elevate CSF OT levels.

76 FR 12278 - Amendment to and Revocation of Reporting Points; Hawaii

Science.gov (United States)

2011-03-07

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 [Docket No. FAA-2011-0018; Airspace Docket No. 10-AWP-18] Amendment to and Revocation of Reporting Points; Hawaii AGENCY... scope of that authority as it amends Reporting Points in Hawaii. Environmental Review The FAA has...

Global Delivery Models

DEFF Research Database (Denmark)

Manning, Stephan; Larsen, Marcus M.; Bharati, Pratyush

2013-01-01

This article examines antecedents and performance implications of global delivery models (GDMs) in global business services. GDMs require geographically distributed operations to exploit both proximity to clients and time-zone spread for efficient service delivery. We propose and empirically show...

A system for EPID-based real-time treatment delivery verification during dynamic IMRT treatment.

Science.gov (United States)

Fuangrod, Todsaporn; Woodruff, Henry C; van Uytven, Eric; McCurdy, Boyd M C; Kuncic, Zdenka; O'Connor, Daryl J; Greer, Peter B

2013-09-01

To design and develop a real-time electronic portal imaging device (EPID)-based delivery verification system for dynamic intensity modulated radiation therapy (IMRT) which enables detection of gross treatment delivery errors before delivery of substantial radiation to the patient. The system utilizes a comprehensive physics-based model to generate a series of predicted transit EPID image frames as a reference dataset and compares these to measured EPID frames acquired during treatment. The two datasets are using MLC aperture comparison and cumulative signal checking techniques. The system operation in real-time was simulated offline using previously acquired images for 19 IMRT patient deliveries with both frame-by-frame comparison and cumulative frame comparison. Simulated error case studies were used to demonstrate the system sensitivity and performance. The accuracy of the synchronization method was shown to agree within two control points which corresponds to approximately ∼1% of the total MU to be delivered for dynamic IMRT. The system achieved mean real-time gamma results for frame-by-frame analysis of 86.6% and 89.0% for 3%, 3 mm and 4%, 4 mm criteria, respectively, and 97.9% and 98.6% for cumulative gamma analysis. The system can detect a 10% MU error using 3%, 3 mm criteria within approximately 10 s. The EPID-based real-time delivery verification system successfully detected simulated gross errors introduced into patient plan deliveries in near real-time (within 0.1 s). A real-time radiation delivery verification system for dynamic IMRT has been demonstrated that is designed to prevent major mistreatments in modern radiation therapy.

Children's Environmental Concerns: Expressing Ecophobia

Science.gov (United States)

Strife, Susan Jean

2012-01-01

While numerous quantitative studies across disciplines have investigated children's knowledge and attitudes about environmental problems, few studies examine children's feelings about environmental problems--and even fewer have focused on the child's point of view. Through 50 in-depth interviews with urban children (ages 10-12) this research aimed…

Adaptive Management of Return Flows: Lessons from a Case Study in Environmental Water Delivery to a Floodplain River

Science.gov (United States)

Wolfenden, Benjamin J.; Wassens, Skye M.; Jenkins, Kim M.; Baldwin, Darren S.; Kobayashi, Tsuyoshi; Maguire, James

2018-03-01

For many floodplain rivers, reinstating wetland connectivity is necessary for ecosystems to recover from decades of regulation. Environmental return flows (the managed delivery of wetland water to an adjacent river) can be used strategically to facilitate natural ecosystem connectivity, enabling the transfer of nutrients, energy, and biota from wetland habitats to the river. Using an informal adaptive management framework, we delivered return flows from a forested wetland complex into a large lowland river in south-eastern Australia. We hypothesized that return flows would (a) increase river nutrient concentrations; (b) reduce wetland nutrient concentrations; (c) increase rates of ecosystem metabolism through the addition of potentially limiting nutrients, causing related increases in the concentration of water column chlorophyll-a; and (d) increase the density and species richness of microinvertebrates in riverine benthic habitats. Our monitoring results demonstrated a small increase in the concentrations of several key nutrients but no evidence for significant ecological responses was found. Although return flows can be delivered from forested floodplain areas without risking hypoxic blackwater events, returning nutrient and carbon-rich water to increase riverine productivity is limited by the achievable scale of return flows. Nevertheless, using return flows to flush carbon from floodplains may be a useful management tool to reduce carbon loads, preparing floodplains for subsequent releases (e.g., mitigating the risk of hypoxic blackwater events). In this example, adaptive management benefited from a semi-formal collaboration between science and management that allowed for prompt decision-making.

Challenges and Opportunities of Centrifugal Microfluidics for Extreme Point-of-Care Testing

Directory of Open Access Journals (Sweden)

Issac J. Michael

2016-02-01

Full Text Available The advantages offered by centrifugal microfluidic systems have encouraged its rapid adaptation in the fields of in vitro diagnostics, clinical chemistry, immunoassays, and nucleic acid tests. Centrifugal microfluidic devices are currently used in both clinical and point-of-care settings. Recent studies have shown that this new diagnostic platform could be potentially used in extreme point-of-care settings like remote villages in the Indian subcontinent and in Africa. Several technological inventions have decentralized diagnostics in developing countries; however, very few microfluidic technologies have been successful in meeting the demand. By identifying the finest difference between the point-of-care testing and extreme point-of-care infrastructure, this review captures the evolving diagnostic needs of developing countries paired with infrastructural challenges with technological hurdles to healthcare delivery in extreme point-of-care settings. In particular, the requirements for making centrifugal diagnostic devices viable in developing countries are discussed based on a detailed analysis of the demands in different clinical settings including the distinctive needs of extreme point-of-care settings.

Automobile - environmental impact

International Nuclear Information System (INIS)

Franze, H.

1993-01-01

The way balances have been drawn up by business companies until now, they can be regarded as an attempt to develop an instrument for environmental management within the company that makes it possible to examine the ecological effects of the manufactured products during their life cycle. The strong points of such ecobalances can be put to use in the following areas in the future: Information on products and processes obtained through an analysis of the weakest points of the production process can be used for puposes of environmental management. With the aid of such examinations for weak points it then becomes possible to optimise products or processes. Comparative studies extending over years permit an assessment of corporate measures for environment protection and process adjustment. Moreover, ecobalances can serve as a guide for the selection of component concepts. The advantage of a balance related to the whole life cycle lies above all in the fact that the piecemeal studies on energy consumption and waste accumulation by stage can now be replaced by an integral, comprehensive registration of data and processes. (orig./UA) [de

Mode of delivery following successful external cephalic version: comparison with spontaneous cephalic presentations at delivery.

Science.gov (United States)

Kuppens, Simone M I; Hutton, Eileen K; Hasaart, Tom H M; Aichi, Nassira; Wijnen, Henrica A; Pop, Victor J M

2013-10-01

To compare the obstetric outcomes of pregnant women after successful external cephalic version (ECV) (cases) with a large group of pregnant women with a spontaneously occurring cephalic fetal position at delivery (controls). We conducted a retrospective matched cohort study in a teaching hospital in the Netherlands. Delivery outcomes of women with a successful ECV were compared with those of women with spontaneously occurring cephalic presentations, controlling for maternal age, parity, gestational age at delivery, and onset of labour (spontaneous or induced). Exclusion criteria were a history of Caesarean section, delivery at < 35 weeks, and elective Caesarean section. The primary outcome was the prevalence of Caesarean section and instrumental delivery in both groups; secondary outcomes were the characteristics of cases requiring intervention such as Caesarean section or instrumental delivery. Women who had a successful ECV had a significantly higher Caesarean section rate than the women in the control group (33/220 [15%] vs. 62/1030 [6.0 %]; P < 0.001). There was no difference in the incidence of instrumental delivery (20/220 [9.1%] vs. 103/1030 [10%]). Comparison of characteristics of women in the cases group showed that nulliparity, induction of labour, and occiput posterior presentation were associated with Caesarean section and instrumental deliveries. Compared with delivery of spontaneous cephalic presenta-tions, delivery of cephalic presenting babies following successful ECV is associated with an increased rate of Caesarean section, especially in nulliparous women and women whose labour is induced.

Local or district heating by natural gas: Which is better from energetic, environmental and economic point of views?

International Nuclear Information System (INIS)

Lazzarin, R.; Noro, M.

2006-01-01

Generally, a CHP plant coupled with district heating is considered more efficient than traditional local heating systems from an economic and environmental point of view. This is certainly true for municipal waste CHP plants, but for plants fuelled by natural gas the important developments of the last years regarding both boilers (premixed and modulating burners, condensing boilers, etc.) and mechanical vapour compression and absorption heat pumps can change the traditional view. At the same time also district heating plants improved. Therefore it is worth to analyse the whole matter comparing advantages and disadvantages of the different alternatives, with a wide difference between them. The paper reports on the analysis of major district heating natural gas based technologies (vapour and gas turbines, internal combustion engine, combined cycles); the cost of heat and power produced in these plants is compared to the cost of producing the same quantity of electrical energy by a reference GTCC-Gas Turbine Combined Cycle (actually the most efficient technology for pure electrical production) and the cost of heat production by modern local heating technologies using natural gas as fuel (condensing boilers, electrical, gas engine and absorption heat pumps). Regarding energy efficiency and emissions, modern local heating turns out to be more efficient than district heating for most CHP technologies. However, the same does not happen from an economic point of view, because in Italy natural gas used by cogeneration plants is subjected to a much lower taxation than local heating technologies

Articulating feedstock delivery device

Science.gov (United States)

Jordan, Kevin

2013-11-05

A fully articulable feedstock delivery device that is designed to operate at pressure and temperature extremes. The device incorporates an articulating ball assembly which allows for more accurate delivery of the feedstock to a target location. The device is suitable for a variety of applications including, but not limited to, delivery of feedstock to a high-pressure reaction chamber or process zone.

The decision on the application to carry out a decommissioning project at Hinkley Point A Power Station under the Nuclear Reactors (Environmental Impact Assessment for Decommissioning) Regulations 1999

International Nuclear Information System (INIS)

2003-01-01

European Council Directive 85/337/EEC, as amended by Council Directive 97/1 I/EC, sets out a framework on the assessment of the effects of certain public and private projects on the environment. The Directive is implemented in Great Britain for decommissioning nuclear reactor projects by the Nuclear Reactors (Environmental Impact Assessment for Decommissioning) Regulations 1999. The intention of the Directive and Regulations is to involve the public through consultation in considering the potential environmental impacts of a decommissioning project, and to make the decision-making process on granting consent open and transparent. The Regulations require the licensee to undertake an environmental impact assessment, prepare an environmental statement that summarises the environmental effects of the project, and apply to the Health and Safety Executive (HSE) for consent to carry out a decommissioning project. There is an optional stage where the licensee may request from HSE an opinion on what the environmental statement should contain (called a pre-application opinion). The licensee of Hinkley Point A Power Station, Magnox Electric pie, requested a pre-application opinion and provided information in a scoping report in December 2000. HSE undertook a public consultation on the scoping report and provided its pre- application opinion in April 2001. The licensee applied to HSE for consent to carry out a decommissioning project and provided an environmental statement in December 2001. Following a public consultation on the environmental statement, HSE requested further information that was subsequently provided by the licensee. A further public consultation was undertaken on the further information that ended in March 2003. All these public consultations involved around 60 organisations. HSE granted consent to carry out a decommissioning project at Hinkley Point A Power Station under the Regulations in July 2003, and attached conditions to the Consent. HSE took relevant

Functionalized bimodal mesoporous silicas as carriers for controlled aspirin delivery

Science.gov (United States)

Gao, Lin; Sun, Jihong; Li, Yuzhen

2011-08-01

The bimodal mesoporous silica modified with 3-aminopropyltriethoxysilane was performed as the aspirin carrier. The samples' structure, drug loading and release profiles were characterized with X-ray diffraction, scanning electron microscopy, N 2 adsorption and desorption, Fourier transform infrared spectroscopy, TG analysis, elemental analysis and UV-spectrophotometer. For further exploring the effects of the bimodal mesopores on the drug delivery behavior, the unimodal mesoporous material MCM-41 was also modified as the aspirin carrier. Meantime, Korsmeyer-Peppas equation ft= ktn was employed to analyze the dissolution data in details. It is indicated that the bimodal mesopores are beneficial for unrestricted drug molecules diffusing and therefore lead to a higher loading and faster releasing than that of MCM-41. The results show that the aspirin delivery properties are influenced considerably by the mesoporous matrix, whereas the large pore of bimodal mesoporous silica is the key point for the improved controlled-release properties.

Abandoned Uranium Mine (AUM) Trust Mine Points, Navajo Nation, 2016, US EPA Region 9

Data.gov (United States)

U.S. Environmental Protection Agency — This GIS dataset contains point features that represent mines included in the Navajo Environmental Response Trust. This mine category also includes Priority mines....

An investigation of environmental and sustainability discourses associated with the substantive purposes of environmental assessment

Energy Technology Data Exchange (ETDEWEB)

Rozema, Jaap G., E-mail: j.rozema@uea.ac.uk [Science, Society and Sustainability Research Group, School of Environmental Sciences, University of East Anglia (UEA), Norwich, NR4 7TJ (United Kingdom); Bond, Alan J., E-mail: alan.bond@uea.ac.uk [Science, Society and Sustainability Research Group, School of Environmental Sciences, University of East Anglia (UEA), Norwich, NR4 7TJ (United Kingdom); Cashmore, Matthew, E-mail: cashmore@plan.aau.dk [Danish Centre for Environmental Assessment, Department of Development and Planning, Aalborg University, Fibigerstraede 13, 9220 Aalborg O (Denmark); Chilvers, Jason, E-mail: jason.chilvers@uea.ac.uk [Science, Society and Sustainability Research Group, School of Environmental Sciences, University of East Anglia (UEA), Norwich, NR4 7TJ (United Kingdom)

2012-02-15

This paper investigates the discursive construction of the substantive purposes of environmental assessment (EA). It addresses these purposes by exploring the complex and often multifaceted linkages between political factors and plural views of democracy, public participation, and the role of science that are embedded in environmental and sustainability discourses. The interaction between policy-making and public actors leads to the formulation of divergent and potentially competing rationales for public participation, and for social appraisal more generally. Participatory approaches have also given impetus to the development of several interpretations on the role of science in assessment procedures. Science is important in mediating public participation and the two are therefore reciprocally linked. This leads to discourses that become manifest in the construction of substantive purposes. Discourse analysis in EA is a relevant method for examining trends and patterns in sustainable development. It is argued that public participation is an important, if not decisive, variable in the articulation and civil legitimacy of certain purposes. A general proposition that results from this paper is that EA, although typically presented as an objective scientific tool, is an intrinsically normative process. Enhanced knowledge on the construction, and reconstruction over time, of substantive purposes is required if environmental and sustainability discourses are to be used and understood as meaningful analytical instruments to assess the socio-political implications of EA. - Highlights: Black-Right-Pointing-Pointer Substantive purposes related to environmental assessment may be best analyzed through discourse analysis. Black-Right-Pointing-Pointer Environmental and sustainability discourses are contingent on the level of participatory democracy and civic science. Black-Right-Pointing-Pointer Public participation is a decisive variable in the construction of the substantive

Environmental Performance of Kettle Production: Product Life Cycle Assessment

Science.gov (United States)

Marcinkowski, Andrzej; Zych, Krzysztof

2017-12-01

The main objective of this paper is to compare the environmental impact caused by two different types of water boiling processes. The aim was achieved thanks to product life cycle assessment (LCA) conducted for stovetop and electric kettles. A literature review was carried out. A research model was worked out on the basis of data available in literature as well as additional experiments. In order to have a better opportunity to compare LCA results with reviewed literature, eco-indicator 99 assessment method was chosen. The functional unit included production, usage and waste disposal of each product (according to from cradle to grave approach) where the main function is boiling 3360 l of water during 4-year period of time. A very detailed life cycle inventory was carried out. The mass of components was determined with accuracy of three decimal places (0.001 g). The majority of environmental impact is caused by electricity or natural gas consumption during usage stage: 92% in case of the electric and kettle and 99% in case of stovetop one. Assembly stage contributed in 7% and 0.8% respectively. Uncertainty and sensitivity analyses took into consideration various waste scenario patterns as well as demand for transport. Environmental impact turned out to be strongly sensitive to a chosen pattern of energy delivery (electricity mix) which determined final comparison results. Basing on LCA results, some improvements of products were suggested. The boiling time optimization was pointed out for electric kettle's efficiency improvement. Obtained results can be used by manufacturers in order to improve their eco-effectiveness. Moreover, conclusions following the research part can influence the future choices of home appliances users.

ENVIRONMENTAL PERFORMANCE OF KETTLE PRODUCTION: PRODUCT LIFE CYCLE ASSESSMENT

Directory of Open Access Journals (Sweden)

Andrzej MARCINKOWSKI

2017-10-01

Full Text Available The main objective of this paper is to compare the environmental impact caused by two different types of water boiling processes. The aim was achieved thanks to product life cycle assessment (LCA conducted for stovetop and electric kettles. A literature review was carried out. A research model was worked out on the basis of data available in literature as well as additional experiments. In order to have a better opportunity to compare LCA results with reviewed literature, eco-indicator 99 assessment method was chosen. The functional unit included production, usage and waste disposal of each product (according to from cradle to grave approach where the main function is boiling 3360 l of water during 4- year period of time. A very detailed life cycle inventory was carried out. The mass of components was determined with accuracy of three decimal places (0.001 g. The majority of environmental impact is caused by electricity or natural gas consumption during usage stage: 92% in case of the electric and kettle and 99% in case of stovetop one. Assembly stage contributed in 7% and 0.8% respectively. Uncertainty and sensitivity analyses took into consideration various waste sce-nario patterns as well as demand for transport. Environmental impact turned out to be strongly sensitive to a chosen pattern of energy delivery (electricity mix which determined final comparison results. Basing on LCA results, some im-provements of products were suggested. The boiling time optimization was pointed out for electric kettle's efficiency improvement. Obtained results can be used by manufacturers in order to improve their eco-effectiveness. Moreover, conclusions following the research part can influence the future choices of home appliances users.

Combating transnational environmental crime

Directory of Open Access Journals (Sweden)

Pisarić Milana

2011-01-01

Full Text Available Environmental crime is a serious and growing international problem, and one which takes many different forms. It is not limited to criminals polluting the air, water and land and pushing commercially valuable wildlife species closer to extinction; it can also include crimes which speed up climate change, destroy fish stocks, annihilate forests and exhaust essential natural resources. These crimes can have a harmful impact on the economies and security of multiple nations, in some cases they may even threaten the very existence of a country or people. Furthermore, a significant proportion of both wildlife crime and pollution crime cases point to the involvement of organized crime networks. This is evidenced by the detailed planning of operations, substantial financial support, the careful management of international shipments and massive profits. Still, to date, transnational environmental crime has been poorly attended to by the transnational organised crime and transnational policing discourse. National and international institutions have prioritised other forms of organised crime, giving little thought to the nuances of environmental crime and how they should be reflected in policing. Intention of this paper is to point out the importance of international cooperation and to point out the its good examples.

Stoppage - Vat Return and Accounting Practice in Re-Delivery of a Delivery Subject to Stoppage

Directory of Open Access Journals (Sweden)

Ahmet Yanık

2016-12-01

Full Text Available Value Added Tax (VAT is calculated based on the goods and service delivery costs realized by the corporations. Unless this VAT is subject to stoppage, seller takes the VAT from the purchaser in delivery of goods or services and then the corporate pays this amount to the tax office or sets off through the VAT he paid for his service or goods procurement. However, in some cases, Ministry of Finance holds not those providing the delivery or service but those purchasing or procuring the goods or services responsible partly or fully for the tax calculated based on the delivery or service fee. The purpose of this paper is to reveal VAT stoppage, accounting entries with regards to the corporation accepting the delivery and re-delivering it, VAT set off and VAT return in the re-delivery of a delivery subject to stoppage pursuant to General Communiqué of VAT Serial No 117

Environmental radiation monitoring around Korea Nuclear Fuel Company

Energy Technology Data Exchange (ETDEWEB)

Lee, Myung Ho; Lee, Chang Woo; Choi, Yong Ho; Cho, Yueng Hyun; Choi, Gyun Sik [Korea Atomic Energy Research Institute, Taejon (Korea)

1999-12-01

Environmental Radiation Monitoring was carried out with measurement of environmental radiation and environmental radioactivity analysis around Korea Nuclear Fuel Company. Environmental Radiation rates measured by Portable ERM and accumulated dose rates measured by TLD were same level compared with past years. Total alpha and beta concentrations in the air particulates showed the similar values in all sampling points. The concentration of uranium isotopes in soils and underground waters were measured similar to natural uranium values. The concentration of uranium isotopes in surface waters and sediments decreased with increasing distances from the point of discharge. The concentrations of uranium isotopes in rain water and foods such as rices and vegetables were not detected or measured similar to natural uranium level. Hence, the environment around the nuclear facilities in Korea has been contaminated only to an insignificant extent, although a small amount of disequilibated uranium was detected within 4 km downstream of the point of discharge of KNFC. 31 refs., 26 figs., 42 tabs. (Author)

Bulk Fuel Storage Requirements for Maintenance, Repair, and Environmental Projects at Fort Hood, Texas

National Research Council Canada - National Science Library

Carros, Deborah

2000-01-01

This report is one in a series that addresses the accuracy and reliability of maintenance, repair, environmental, and construction requirements for bulk fuel storage and delivery systems infrastructure...

A Monte Carlo tool for evaluating VMAT and DIMRT treatment deliveries including planar detectors

International Nuclear Information System (INIS)

Asuni, G; Van Beek, T A; Venkataraman, S; McCurdy, B M C; Popescu, I A

2013-01-01

The aim of this work is to describe and validate a new general research tool that performs Monte Carlo (MC) simulations for volumetric modulated arc therapy (VMAT) and dynamic intensity modulated radiation therapy (DIMRT), simultaneously tracking dose deposition in both the patient CT geometry and an arbitrary planar detector system. The tool is generalized to handle either entrance or exit detectors and provides the simulated dose for the individual control-points of the time-dependent VMAT and DIMRT deliveries. The MC simulation tool was developed with the EGSnrc radiation transport. For the individual control point simulation, we rotate the patient/phantom volume only (i.e. independent of the gantry and planar detector geometries) using the gantry angle in the treatment planning system (TPS) DICOM RP file such that each control point has its own unique phantom file. After MC simulation, we obtained the total dose to the phantom by summing dose contributions for all control points. Scored dose to the sensitive layer of the planar detector is available for each control point. To validate the tool, three clinical treatment plans were used including VMAT plans for a prostate case and a head-and-neck case, and a DIMRT plan for a head-and-neck case. An electronic portal imaging device operated in ‘movie’ mode was used with the VMAT plans delivered to cylindrical and anthropomorphic phantoms to validate the code using an exit detector. The DIMRT plan was delivered to a novel transmission detector, to validate the code using an entrance detector. The total MC 3D absolute doses in patient/phantom were compared with the TPS doses, while 2D MC doses were compared with planar detector doses for all individual control points, using the gamma evaluation test with 3%/3 mm criteria. The MC 3D absolute doses demonstrated excellent agreement with the TPS doses for all the tested plans, with about 95% of voxels having γ 90% of percentage pixels with γ <1. We found that over

Focal points 2010. Mobility with future - correct investment today. Environmental protection - investment restraint for agriculture? Engine for the climate policy: emission trading; Schwerpunkte 2010. Mobilitaet mit Zukunft - heute richtig investieren. Umweltschutz - Investitionshemmnis fuer die Landwirtschaft? Motor fuer die Klimapolitik: Der Emissionshandel

Energy Technology Data Exchange (ETDEWEB)

Ittershagen, Martin; Mavromati, Fotini (comps.)

2010-04-14

The publication of the German Federal environmental agency on the focal points 2010 covers the following topics: impetus for an ecological-economic policy; mobility with future -best investment for today: more environmentally compatible investments in traffic infrastructure, better technology - more efficiency, missing charging of environmental cost induces wrong stimuli; environmental protection - investment restraints for agriculture? Engine for climate policy: emission trading; the Federal environmental agency: bridge between science and politics, the Federal environmental agency for mankind and environment; data and facts; publications of the employees.

The impact of treatment complexity and computer-control delivery technology on treatment delivery errors

International Nuclear Information System (INIS)

Fraass, Benedick A.; Lash, Kathy L.; Matrone, Gwynne M.; Volkman, Susan K.; McShan, Daniel L.; Kessler, Marc L.; Lichter, Allen S.

1998-01-01

Purpose: To analyze treatment delivery errors for three-dimensional (3D) conformal therapy performed at various levels of treatment delivery automation and complexity, ranging from manual field setup to virtually complete computer-controlled treatment delivery using a computer-controlled conformal radiotherapy system (CCRS). Methods and Materials: All treatment delivery errors which occurred in our department during a 15-month period were analyzed. Approximately 34,000 treatment sessions (114,000 individual treatment segments [ports]) on four treatment machines were studied. All treatment delivery errors logged by treatment therapists or quality assurance reviews (152 in all) were analyzed. Machines 'M1' and 'M2' were operated in a standard manual setup mode, with no record and verify system (R/V). MLC machines 'M3' and 'M4' treated patients under the control of the CCRS system, which (1) downloads the treatment delivery plan from the planning system; (2) performs some (or all) of the machine set up and treatment delivery for each field; (3) monitors treatment delivery; (4) records all treatment parameters; and (5) notes exceptions to the electronically-prescribed plan. Complete external computer control is not available on M3; therefore, it uses as many CCRS features as possible, while M4 operates completely under CCRS control and performs semi-automated and automated multi-segment intensity modulated treatments. Analysis of treatment complexity was based on numbers of fields, individual segments, nonaxial and noncoplanar plans, multisegment intensity modulation, and pseudoisocentric treatments studied for a 6-month period (505 patients) concurrent with the period in which the delivery errors were obtained. Treatment delivery time was obtained from the computerized scheduling system (for manual treatments) or from CCRS system logs. Treatment therapists rotate among the machines; therefore, this analysis does not depend on fixed therapist staff on particular

Global Delivery Models

DEFF Research Database (Denmark)

Manning, Stephan; Møller Larsen, Marcus; Bharati, Pratyush

-zone spread allowing for 24/7 service delivery and access to resources. Based on comprehensive data we show that providers are likely to establish GDM configurations when clients value access to globally distributed talent pools and speed of service delivery, and in particular when services are highly...

A framework for the organization and delivery of systemic treatment.

Science.gov (United States)

Vandenberg, T; Coakley, N; Nayler, J; Degrasse, C; Green, E; Mackay, J A; McLennan, C; Smith, A; Wilcock, L; Trudeau, M E

2009-01-01

Increasing systemic treatment and shortages of oncology professionals in Canada require innovative approaches to the safe and effective delivery of intravenous (IV) cancer treatment. We conducted a systematic review of the clinical and scientific literature, and an environmental scan of models in Canada, the United Kingdom, Australia, and New Zealand. We then developed a framework for the organization and delivery of IV systemic treatment. The systematic review covered the medline, embase, cinahl, and HealthStar databases. The environmental scan retrieved published and unpublished sources, coupled with a free key word search using the Google search engine. The Systemic Treatment Working Group reviewed the evidence and developed a draft framework using evidence-based analysis, existing recommendations from various jurisdictions, and expert opinion based on experience and consensus. The draft was assessed by Ontario stakeholders and reviewed and approved by Cancer Care Ontario. The poor quantity and quality of the evidence necessitated a consensus-derived model. That model comprises four levels of care determined by a regional systemic treatment program and three integrated structures (integrated cancer programs, affiliate institutions, and satellite institutions), each with a defined scope of practice and a specific organizational framework. New models of care are urgently required beyond large centres, particularly in geographically remote or rural areas. Despite limited applicable evidence, the development and successful implementation of this framework is intended to create sustainable, accessible, quality care and to measurably improve patient outcomes.

TH-CD-209-10: Scanning Proton Arc Therapy (SPArc) - The First Robust and Delivery-Efficient Spot Scanning Proton Arc Therapy

International Nuclear Information System (INIS)

Ding, X; Li, X; Zhang, J; Kabolizadeh, P; Stevens, C; Yan, D

2016-01-01

Purpose: To develop a delivery-efficient proton spot-scanning arc therapy technique with robust plan quality. Methods: We developed a Scanning Proton Arc(SPArc) optimization algorithm integrated with (1)Control point re-sampling by splitting control point into adjacent sub-control points; (2)Energy layer re-distribution by assigning the original energy layers to the new sub-control points; (3)Energy layer filtration by deleting low MU weighting energy layers; (4)Energy layer re-sampling by sampling additional layers to ensure the optimal solution. A bilateral head and neck oropharynx case and a non-mobile lung target case were tested. Plan quality and total estimated delivery time were compared to original robust optimized multi-field step-and-shoot arc plan without SPArc optimization (Arcmulti-field) and standard robust optimized Intensity Modulated Proton Therapy(IMPT) plans. Dose-Volume-Histograms (DVH) of target and Organ-at-Risks (OARs) were analyzed along with all worst case scenarios. Total delivery time was calculated based on the assumption of a 360 degree gantry room with 1 RPM rotation speed, 2ms spot switching time, beam current 1nA, minimum spot weighting 0.01 MU, energy-layer-switching-time (ELST) from 0.5 to 4s. Results: Compared to IMPT, SPArc delivered less integral dose(−14% lung and −8% oropharynx). For lung case, SPArc reduced 60% of skin max dose, 35% of rib max dose and 15% of lung mean dose. Conformity Index is improved from 7.6(IMPT) to 4.0(SPArc). Compared to Arcmulti-field, SPArc reduced number of energy layers by 61%(276 layers in lung) and 80%(1008 layers in oropharynx) while kept the same robust plan quality. With ELST from 0.5s to 4s, it reduced 55%–60% of Arcmulti-field delivery time for the lung case and 56%–67% for the oropharynx case. Conclusion: SPArc is the first robust and delivery-efficient proton spot-scanning arc therapy technique which could be implemented in routine clinic. For modern proton machine with ELST close

Environmental Complexity: ethic-environmental propositions of the Latin- American Environmental Thought

International Nuclear Information System (INIS)

Noguera de Echeverri, Ana Patricia

2007-01-01

In this article, are compiled the most important ethic-environmental propositions of the Latin- American Environmental Thought, that had been growing up 30 years ago. In it are authors outlined in the field of the philosophic environmental thought, as the philosopher and Colombian thinker, of Latin-American transcendence, Augusto Angel Maya, who pustules the possibility of build en Ethical - Esthetic Environmental Philosophy, in fact of the Modern Philosophy have been metaphysic, even in the empiric, positivist and neo-positivist tendencies. It has been outlined the Enrique Leff's work, Mexican, who proposes his concepts of Complexity and Environmental Known as an initial point of an ethic in the education, science and technology into of an systemic and holistic relations. Equally, the Julio Carrizosa's ethical - esthetic proposition, also Colombian, which this essay shows as a fundamental political propose against Colombian problems as violence and exclusion. The propositions of Colombian philosophers of big relevance in the politic-moral philosophy had become in a public and communicative environmental ethic, that's the case of Guillermo Hoyos Vasquez and other thinkers as in Colombia and so other Latin-American countries which are shown in this space, with the finality of to pick up in a critical way our ideas about the possibility of an environmental ethic, that means an decentred ethic, with out subject and object, and systemic ethic, where the values has come being constructed 2.500 millions years ago, of which we are pure threads, an ethic that pass of been an object to be first a value in his greater sense

What Is a Cesarean Delivery?

Science.gov (United States)

... Twitter Pinterest Email Print What is a cesarean delivery? A cesarean delivery is a surgical procedure in which a fetus ... 32.2% of U.S. births were by cesarean delivery. 2 The CDC also found that the number ...

Synthetic sustained gene delivery systems.

Science.gov (United States)

Agarwal, Ankit; Mallapragada, Surya K

2008-01-01

Gene therapy today is hampered by the need of a safe and efficient gene delivery system that can provide a sustained therapeutic effect without cytotoxicity or unwanted immune responses. Bolus gene delivery in solution results in the loss of delivered factors via lymphatic system and may cause undesired effects by the escape of bioactive molecules to distant sites. Controlled gene delivery systems, acting as localized depot of genes, provide an extended sustained release of genes, giving prolonged maintenance of the therapeutic level of encoded proteins. They also limit the DNA degradation in the nuclease rich extra-cellular environment. While attempts have been made to adapt existing controlled drug delivery technologies, more novel approaches are being investigated for controlled gene delivery. DNA encapsulated in nano/micro spheres of polymers have been administered systemically/orally to be taken up by the targeted tissues and provide sustained release once internalized. Alternatively, DNA entrapped in hydrogels or scaffolds have been injected/implanted in tissues/cavities as platforms for gene delivery. The present review examines these different modalities for sustained delivery of viral and non-viral gene-delivery vectors. Design parameters and release mechanisms of different systems made with synthetic or natural polymers are presented along with their prospective applications and opportunities for continuous development.

Architectural Principles for Orchestration of Cross-Organizational Service Delivery: Case Studies from the Netherlands

Science.gov (United States)

van Veenstra, Anne Fleur; Janssen, Marijn

One of the main challenges for e-government is to create coherent services for citizens and businesses. Realizing Integrated Service Delivery (ISD) requires government agencies to collaborate across their organizational boundaries. The coordination of processes across multiple organizations to realize ISD is called orchestration. One way of achieving orchestration is to formalize processes using architecture. In this chapter we identify architectural principles for orchestration by looking at three case studies of cross-organizational service delivery chain formation in the Netherlands. In total, six generic principles were formulated and subsequently validated in two workshops with experts. These principles are: (i) build an intelligent front office, (ii) give processes a clear starting point and end, (iii) build a central workflow application keeping track of the process, (iv) differentiate between simple and complex processes, (v) ensure that the decision-making responsibility and the overview of the process are not performed by the same process role, and (vi) create a central point where risk profiles are maintained. Further research should focus on how organizations can adapt these principles to their own situation.

Environmental radiation monitoring around the nuclear facilities

International Nuclear Information System (INIS)

Lee, H.D.; Lee, Y.B.; Lee, W.Y.; Park, D.W.; Chung, B.G.

1980-01-01

For the KAERI site, various environmental samples were collected three times a month, and the natural environmental radiation levels were also measured at each sampling point. Measurements for gross alpha and beta radioactivities of the samples were routinely measured for all samples. Strontium-90 concentrations were also analysed for the fallout and air samples collected daily basis on the roof of the main building. Accumulated exposure including the possibility of determination of low level environmental radiation field by employing thermoluminescent dosimeter, CaSO 4 : Dsub(y)-0.4 teflon disc type, at 6 posts in on-site of the KAERI. As for Kori site, at 19 points of ON, OFF-site, and at the same time the environmental radiation exposure rate at each sampling point were measured. Several environmental samples such as surface soil, pine needles, water samples, milk sample and pasture samples were collected and analysed on a quarterly basis. As a result of the survey it can be said that no significant release of radiation to the environment due to the operations of nuclear facilities including research reactor at the KAERI and power reactor at the Kori has been found during the period of the survey and monitoring. (author)

Project delivery system (PDS)

CERN Document Server

2001-01-01

As business environments become increasingly competitive, companies seek more comprehensive solutions to the delivery of their projects. "Project Delivery System: Fourth Edition" describes the process-driven project delivery systems which incorporates the best practices from Total Quality and is aligned with the Project Management Institute and ISO Quality Standards is the means by which projects are consistently and efficiently planned, executed and completed to the satisfaction of clients and customers.

Supplier Cooperation in Drone Delivery

OpenAIRE

Sawadsitang, Suttinee; Niyato, Dusit; Siew, Tan Puay; Wang, Ping

2018-01-01

Recently, unmanned aerial vehicles (UAVs), also known as drones, has emerged as an efficient and cost-effective solution for package delivery. Especially, drones are expected to incur lower cost, and achieve fast and environment friendly delivery. While most of existing drone research concentrates on surveillance applications, few works studied the drone package delivery planning problem. Even so, the previous works only focus on the drone delivery planning of a single supplier. In this paper...

Investigating the Relationship between Mode of Delivery and Dysmenorrheal in 15-49 Year Old Women in Ahvaz

Directory of Open Access Journals (Sweden)

P Shahri

2013-06-01

Full Text Available Introduction: Approximately 50% of all women experience dysmenorrhea. It seems that childbirth can decrease menstrual pain; though, significant effect of delivery mode on dysmenorrhea has not been clearly explained. This study was carried out to determine the association between mode of delivery and dysmenorrhea frequency and severity. Methods: This is a cross-sectional and analytical study in which 384 eligible women were selected randomly from 9 health centers in Ahvaz. A questionnaire was used for data collection including two sections of demographic characteristics as well as obstetric and menstrual history. Severity of dysmenorrheal was investigated through verbal Multidimensional scoring system (VMSS and rated on a four-point scale: 0= no dysmenorrhea, 1=minimal, 2=moderate, 3=severe dysmenorrheal. The research data was analyzed through chi-square and McNamara. Results: Frequency of caesarean was 41.4% and frequency of dysmenorrhea was 51.6%, while before the first delivery, it was 79.4%. Before and after delivery most frequent scale in severity of dysmenorrheal involved 1 and 0 respectively. Using McNamara, there was a significant relationship between delivery and frequency of dysmenorrhea (P<0.001; though, type of delivery did not reveal any relationship to the frequency and severity of dysmenorrhea. There was a positive association among frequency of dysmenorrhea with education, ethnicity and occupation. Conclusion: According to the results, overall delivery declines dysmenorrheal, however; there is no difference between vaginal and caesarean delivery. Hence, further researches are required to explore this issue.

Noninvasive ocular drug delivery: potential transcorneal and other alternative delivery routes for therapeutic molecules in glaucoma.

Science.gov (United States)

Foldvari, Marianna

2014-01-01

Drug delivery to the eye is made difficult by multiple barriers (such as the tear film, cornea, and vitreous) between the surface of the eye and the treatment site. These barriers are difficult to surmount for the purposes of drug delivery without causing toxicity. Using nanotechnology tools to control, manipulate, and study delivery systems, new approaches to delivering drugs, genes, and antigens that are effective and safe can be developed. Topical administration to the ocular surface would be the safest method for delivery, as it is noninvasive and painless compared with other delivery methods. However, there is only limited success using topical delivery methods, especially for gene therapy. Current thinking on treatments of the future enabled by nanodelivery systems and the identification of target specificity parameters that require deeper understanding to develop successful topical delivery systems for glaucoma is highlighted.

6. Home deliveries

African Journals Online (AJOL)

Sitwala

determine factors associated with home deliveries. Main outcome ... deliver at home than a health facility compared to those who .... regression analysis, women who had four years of schooling or .... by report bias, the burden of home deliveries is a real challenge .... Journal of Econometrics 1987; 36: 185-204. 14. Michelo ...

[Fathers of first infants--preparatory courses about delivery, experience of delivery and paternity leave].

Science.gov (United States)

Aagaard, J; Dueholm, M; Nielsen, K T; Wiese, J; Strand, J E; Jangaard, J K

1989-05-22

In the Central Hospital in Randers, 233 fathers of first infants replied to a questionnaire which illustrated their attitudes to the preparatory courses about delivery, experience of delivery and attitudes to paternity leave. 65% of the fathers participated in the course and 74% stated that they considered that this had been profitable. Where 77% of the men were concerned, these considered that participation in delivery had been a positive experience. 73% of the men had planned paternity leave around the time of delivery, which emphasizes the need for this arrangement.

A system for EPID-based real-time treatment delivery verification during dynamic IMRT treatment

Energy Technology Data Exchange (ETDEWEB)

Fuangrod, Todsaporn [Faculty of Engineering and Built Environment, School of Electrical Engineering and Computer Science, the University of Newcastle, NSW 2308 (Australia); Woodruff, Henry C.; O’Connor, Daryl J. [Faculty of Science and IT, School of Mathematical and Physical Sciences, the University of Newcastle, NSW 2308 (Australia); Uytven, Eric van; McCurdy, Boyd M. C. [Division of Medical Physics, CancerCare Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba R3E 0V9 (Canada); Department of Physics and Astronomy, University of Manitoba, Winnipeg, Manitoba R3T 2N2 (Canada); Department of Radiology, University of Manitoba, Winnipeg, Manitoba R3T 2N2 (Canada); Kuncic, Zdenka [School of Physics, University of Sydney, Sydney, NSW 2006 (Australia); Greer, Peter B. [Faculty of Science and IT, School of Mathematical and Physical Sciences, the University of Newcastle, NSW 2308, Australia and Department of Radiation Oncology, Calvary Mater Newcastle Hospital, Locked Bag 7, Hunter region Mail Centre, Newcastle, NSW 2310 (Australia)

2013-09-15

Purpose: To design and develop a real-time electronic portal imaging device (EPID)-based delivery verification system for dynamic intensity modulated radiation therapy (IMRT) which enables detection of gross treatment delivery errors before delivery of substantial radiation to the patient.Methods: The system utilizes a comprehensive physics-based model to generate a series of predicted transit EPID image frames as a reference dataset and compares these to measured EPID frames acquired during treatment. The two datasets are using MLC aperture comparison and cumulative signal checking techniques. The system operation in real-time was simulated offline using previously acquired images for 19 IMRT patient deliveries with both frame-by-frame comparison and cumulative frame comparison. Simulated error case studies were used to demonstrate the system sensitivity and performance.Results: The accuracy of the synchronization method was shown to agree within two control points which corresponds to approximately ∼1% of the total MU to be delivered for dynamic IMRT. The system achieved mean real-time gamma results for frame-by-frame analysis of 86.6% and 89.0% for 3%, 3 mm and 4%, 4 mm criteria, respectively, and 97.9% and 98.6% for cumulative gamma analysis. The system can detect a 10% MU error using 3%, 3 mm criteria within approximately 10 s. The EPID-based real-time delivery verification system successfully detected simulated gross errors introduced into patient plan deliveries in near real-time (within 0.1 s).Conclusions: A real-time radiation delivery verification system for dynamic IMRT has been demonstrated that is designed to prevent major mistreatments in modern radiation therapy.

A system for EPID-based real-time treatment delivery verification during dynamic IMRT treatment

International Nuclear Information System (INIS)

Fuangrod, Todsaporn; Woodruff, Henry C.; O’Connor, Daryl J.; Uytven, Eric van; McCurdy, Boyd M. C.; Kuncic, Zdenka; Greer, Peter B.

2013-01-01

Purpose: To design and develop a real-time electronic portal imaging device (EPID)-based delivery verification system for dynamic intensity modulated radiation therapy (IMRT) which enables detection of gross treatment delivery errors before delivery of substantial radiation to the patient.Methods: The system utilizes a comprehensive physics-based model to generate a series of predicted transit EPID image frames as a reference dataset and compares these to measured EPID frames acquired during treatment. The two datasets are using MLC aperture comparison and cumulative signal checking techniques. The system operation in real-time was simulated offline using previously acquired images for 19 IMRT patient deliveries with both frame-by-frame comparison and cumulative frame comparison. Simulated error case studies were used to demonstrate the system sensitivity and performance.Results: The accuracy of the synchronization method was shown to agree within two control points which corresponds to approximately ∼1% of the total MU to be delivered for dynamic IMRT. The system achieved mean real-time gamma results for frame-by-frame analysis of 86.6% and 89.0% for 3%, 3 mm and 4%, 4 mm criteria, respectively, and 97.9% and 98.6% for cumulative gamma analysis. The system can detect a 10% MU error using 3%, 3 mm criteria within approximately 10 s. The EPID-based real-time delivery verification system successfully detected simulated gross errors introduced into patient plan deliveries in near real-time (within 0.1 s).Conclusions: A real-time radiation delivery verification system for dynamic IMRT has been demonstrated that is designed to prevent major mistreatments in modern radiation therapy

On the concavity of delivery games

NARCIS (Netherlands)

Hamers, H.J.M.

1995-01-01

Delivery games, introduced by Hamers, Borm, van de Leensel and Tijs (1994), are combinatorial optimization games that arise from delivery problems closely related to the Chinese postman problem (CPP). They showed that delivery games are not necessarily balanced. For delivery problems corresponding

Prenatal attitudes toward vaginal delivery and actual delivery mode: Variation by race/ethnicity and socioeconomic status.

Science.gov (United States)

Attanasio, Laura B; Hardeman, Rachel R; Kozhimannil, Katy B; Kjerulff, Kristen H

2017-12-01

Researchers documenting persistent racial/ethnic and socioeconomic status disparities in chances of cesarean delivery have speculated that women's birth attitudes and preferences may partially explain these differences, but no studies have directly tested this hypothesis. We examined whether women's prenatal attitudes toward vaginal delivery differed by race/ethnicity or socioeconomic status, and whether attitudes were differently related to delivery mode depending on race/ethnicity or socioeconomic status. Data were from the First Baby Study, a cohort of 3006 women who gave birth to a first baby in Pennsylvania between 2009 and 2011. We used regression models to examine (1) predictors of prenatal attitudes toward vaginal delivery, and (2) the association between prenatal attitudes and actual delivery mode. To assess moderation, we estimated models adding interaction terms. Prenatal attitudes toward vaginal delivery were not associated with race/ethnicity or socioeconomic status. Positive attitudes toward vaginal delivery were associated with lower odds of cesarean delivery (AOR=0.60, P socioeconomic status women may be more able to realize their preferences in childbirth. © 2017 Wiley Periodicals, Inc.

Environmental organisations and the EC. Action options of environmental organisations for improving environmental consciousness and environmental policy in the European Community. Draft summary

International Nuclear Information System (INIS)

Hey, C.; Brendle, U.

1992-01-01

A European-wide awakening of environmental organizations began in the middle of the eighties, about the same time as the political push for EC integration. The European work of the environmental organizations is at a turning point almost everywhere. Most organizations made important structural decisions in the last few years, and the speed of the change has been fast. The landscape of environment organizations is becoming more complex and certainly more politically important on a European level. This push for internationalization will certainly entail an inter-cultural learning process, which could lead to a 'European' identity in the mid-term. The various national condition for environmental organizations in Germany, Spain, Holland, Great Britain, and on a European level are compared here. (orig./DG)

Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs

DEFF Research Database (Denmark)

Christophersen, Philip Carsten; Fano, Mathias; Saaby, Lasse

2015-01-01

Oral drug delivery is a preferred route because of good patient compliance. However, most peptide/ protein drugs are delivered via parenteral routes because of the absorption barriers in the gastrointestinal (GI) tract such as enzymatic degradation by proteases and low permeability acrossthe...... delivery of peptide/protein drugs and to provide an overview of formulationand characterization strategies. For a better understanding of the challenges in oral delivery of peptide/protein drugs, the composition of GI fluids and the digestion processes of different kinds of excipients in the GI tract...... biological membranes. To overcome these barriers, different formulation strategies for oral delivery of biomacromolecules have been proposed, including lipid based formulations and polymer-based particulate drug delivery systems (DDS). The aim of this review is to summarize the existing knowledge about oral...

Engineering solutions of environmental problems in organic waste handling

Science.gov (United States)

Briukhanov, A. Y.; Vasilev, E. V.; Shalavina, E. V.; Kucheruk, O. N.

2017-10-01

This study shows the urgent need to consider modernization of agricultural production in terms of sustainable development, which takes into account environmental implications of intensive technologies in livestock farming. Some science-based approaches are offered to address related environmental challenges. High-end technologies of organic livestock waste processing were substantiated by the feasibility study and nutrient balance calculation. The technologies were assessed on the basis of best available techniques criteria, including measures such as specific capital and operational costs associated with nutrient conservation and their delivery to the plants.

Controlled delivery of ropinirole hydrochloride through skin using modulated iontophoresis and microneedles.

Science.gov (United States)

Singh, Neha D; Banga, Ajay K

2013-05-01

The objective of this study was to investigate the effect of modulated current application using iontophoresis- and microneedle-mediated delivery on transdermal permeation of ropinirole hydrochloride. AdminPatch® microneedles and microchannels formed by them were characterized by scanning electron microscopy, dye staining and confocal microscopy. In vitro permeation studies were carried out using Franz diffusion cells, and skin extraction was used to quantify drug in underlying skin. Effect of microneedle pore density and ions in donor formulation was studied. Active enhancement techniques, continuous iontophoresis (74.13 ± 2.20 µg/cm(2)) and microneedles (66.97 ± 10.39 µg/cm(2)), significantly increased the permeation of drug with respect to passive delivery (8.25 ± 2.41 µg/cm(2)). Modulated iontophoresis could control the amount of drug delivered at a given time point with the highest flux being 5.12 ± 1.70 µg/cm(2)/h (5-7 h) and 5.99 ± 0.81 µg/cm(2)/h (20-22 h). Combination of modulated iontophoresis and microneedles (46.50 ± 6.46 µg/cm(2)) showed significantly higher delivery of ropinirole hydrochloride compared to modulated iontophoresis alone (84.91 ± 9.21 µg/cm(2)). Modulated iontophoresis can help in maintaining precise control over ropinirole hydrochloride delivery for dose titration in Parkinson's disease therapy and deliver therapeutic amounts over a suitable patch area and time.

38 CFR 21.4505 - Check delivery.

Science.gov (United States)

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Check delivery. 21.4505...) VOCATIONAL REHABILITATION AND EDUCATION Education Loans § 21.4505 Check delivery. (a) General. Education... surviving spouse is enrolled for delivery by the educational institution. (b) Delivery and certification. (1...

Nostalgia, gamification and staff development – moving staff training away from didactic delivery

Directory of Open Access Journals (Sweden)

Tom Foster

2018-05-01

Full Text Available There is growing evidence that incorporating games into education supports active learning and student participation. With that in mind, we created a staff development session that involved a playful learning activity, in which attendees experienced 90’s nostalgia, whilst working on an important learning and teaching issue.Based on the British game show, The Crystal Maze, The ‘Crys-TEL’ maze required attendees to complete a number of challenges as a group to attempt to ‘solve’ a pressing learning and teaching issue. Using gamification techniques, defined as game design elements in non-game settings, attendees experienced different delivery styles, whilst always working towards the learning and teaching issue they had been asked to consider. In a nod to the original Crystal Maze game show, attendees worked in groups to score points for completing various tasks. The two groups with the most points competed against each other in the final to collect crystals, and ultimately conquer the ‘maze’.This article will describe the journey we took from the initial concept through to the delivery of the session, and our reflections and proposed future developments of the Crys-TEL Maze.

Advanced content delivery, streaming, and cloud services

CERN Document Server

Sitaraman, Ramesh Kumar; Robinson, Dom

2014-01-01

While other books on the market provide limited coverage of advanced CDNs and streaming technologies, concentrating solely on the fundamentals, this book provides an up-to-date comprehensive coverage of the state-of-the-art advancements in CDNs, with a special focus on Cloud-based CDNs. The book includes CDN and media streaming basics, performance models, practical applications, and business analysis. It features industry case studies, CDN applications, and open research issues to aid practitioners and researchers, and a market analysis to provide a reference point for commercial entities. The book covers Adaptive Bitrate Streaming (ABR), Content Delivery Cloud (CDC), Web Acceleration, Front End Optimization (FEO), Transparent Caching, Next Generation CDNs, CDN Business Intelligence and more.

Proposed patient motion monitoring system using feature point tracking with a web camera.

Science.gov (United States)

Miura, Hideharu; Ozawa, Shuichi; Matsuura, Takaaki; Yamada, Kiyoshi; Nagata, Yasushi

2017-12-01

Patient motion monitoring systems play an important role in providing accurate treatment dose delivery. We propose a system that utilizes a web camera (frame rate up to 30 fps, maximum resolution of 640 × 480 pixels) and an in-house image processing software (developed using Microsoft Visual C++ and OpenCV). This system is simple to use and convenient to set up. The pyramidal Lucas-Kanade method was applied to calculate motions for each feature point by analysing two consecutive frames. The image processing software employs a color scheme where the defined feature points are blue under stable (no movement) conditions and turn red along with a warning message and an audio signal (beeping alarm) for large patient movements. The initial position of the marker was used by the program to determine the marker positions in all the frames. The software generates a text file that contains the calculated motion for each frame and saves it as a compressed audio video interleave (AVI) file. We proposed a patient motion monitoring system using a web camera, which is simple and convenient to set up, to increase the safety of treatment delivery.

Advanced SLARette delivery machine

International Nuclear Information System (INIS)

Bodner, R.R.

1995-01-01

SLARette 1 equipment, comprising of a SLARette Delivery Machine, SLAR Tools, SLAR power supplies and SLAR Inspection Systems was designed, developed and manufactured to service fuel channels of CANDU 6 stations during the regular yearly station outages. The Mark 2 SLARette Delivery Machine uses a Push Tube system to provide the axial and rotary movements of the SLAR Tool. The Push Tubes are operated remotely but must be attached and removed manually. Since this operation is performed at the Reactor face, there is radiation dose involved for the workers. An Advanced SLARette Delivery Machine which incorporates a computer controlled telescoping Ram in the place of the Push Tubes has been recently designed and manufactured. Utilization of the Advanced SLARette Delivery Machine significantly reduces the amount of radiation dose picked up by the workers because the need to have workers at the face of the Reactor during the SLARette operation is greatly reduced. This paper describes the design, development and manufacturing process utilized to produce the Advanced SLARette Delivery Machine and the experience gained during the Gentilly-2 NGS Spring outage. (author)

Environmental Risk Factors in Psoriasis: The Point of View of the Nutritionist

Directory of Open Access Journals (Sweden)

Luigi Barrea

2016-07-01

Full Text Available Psoriasis is a common, chronic, immune-mediated skin disease with systemic pro-inflammatory activation, where both environmental and genetic factors contribute to its pathogenesis. Among the risk factors for psoriasis, evidence is accumulating that nutrition plays a major role, per se, in psoriasis pathogenesis. In particular, body weight, nutrition, and diet may exacerbate the clinical manifestations, or even trigger the disease. Understanding the epidemiological relationship between obesity and psoriasis is also important for delineating the risk profile for the obesity-related comorbidities commonly found among psoriatic patients. Moreover, obesity can affect both drug’s pharmacokinetics and pharmacodynamics. Additionally, the overall beneficial effects on the obesity-associated comorbidities, clinical recommendations to reduce weight and to adopt a healthy lifestyle could improve the psoriasis severity, particularly in those patients with moderate to severe disease, thus exerting additional therapeutic effects in the conventional treatment in obese patients with psoriasis. Education regarding modifiable environmental factors is essential in the treatment of this disease and represents one of the primary interventions that can affect the prognosis of patients with psoriasis. The goal is to make psoriatic patients and health care providers aware of beneficial dietary interventions. The aim of this review is to assess the relevance of the environmental factors as modifiable risk factors in psoriasis pathogenesis, with particular regard to the involvement of obesity and nutrition in the management of psoriasis, providing also specific nutrition recommendations.

19 CFR 10.101 - Immediate delivery.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Immediate delivery. 10.101 Section 10.101 Customs... Importations § 10.101 Immediate delivery. (a) Shipments entitled to immediate delivery. Shipments consigned to... as shipments the immediate delivery of which is necessary within the purview of section 448(b...

Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs.

Science.gov (United States)

Christophersen, Philip Carsten; Fano, Mathias; Saaby, Lasse; Yang, Mingshi; Nielsen, Hanne Mørck; Mu, Huiling

2015-01-01

Oral drug delivery is a preferred route because of good patient compliance. However, most peptide/ protein drugs are delivered via parenteral routes because of the absorption barriers in the gastrointestinal (GI) tract such as enzymatic degradation by proteases and low permeability acrossthe biological membranes. To overcome these barriers, different formulation strategies for oral delivery of biomacromolecules have been proposed, including lipid based formulations and polymer-based particulate drug delivery systems (DDS). The aim of this review is to summarize the existing knowledge about oral delivery of peptide/protein drugs and to provide an overview of formulationand characterization strategies. For a better understanding of the challenges in oral delivery of peptide/protein drugs, the composition of GI fluids and the digestion processes of different kinds of excipients in the GI tract are summarized. Additionally, the paper provides an overview of recent studies on characterization of solid drug carriers for peptide/protein drugs, drug distribution in particles, drug release and stability in simulated GI fluids, as well as the absorption of peptide/protein drugs in cell-based models. The use of biorelevant media when applicable can increase the knowledge about the quality of DDS for oral protein delivery. Hopefully, the knowledge provided in this review will aid the establishment of improved biorelevant models capable of forecasting the performance of particulate DDS for oral peptide/protein delivery.

Pregnancy week at delivery and the risk of shoulder dystocia: a population study of 2,014,956 deliveries.

Science.gov (United States)

Øverland, E A; Vatten, L J; Eskild, A

2014-01-01

To study whether pregnancy week at delivery is an independent risk factor for shoulder dystocia. Population study. Medical Birth Registry of Norway. All vaginal deliveries of singleton offspring in cephalic presentation in Norway during 1967 through 2009 (n = 2,014,956). The incidence of shoulder dystocia was calculated according to pregnancy week at delivery. The associations of pregnancy week at delivery with shoulder dystocia were estimated as crude and adjusted odds ratios using logistic regression analyses. We repeated the analyses in pregnancies with and without maternal diabetes. Shoulder dystocia at delivery. The overall incidence of shoulder dystocia was 0.73% (n = 14,820), and the incidence increased by increasing pregnancy week at delivery. Birthweight was strongly associated with shoulder dystocia. After adjustment for birthweight, induction of labour, use of epidural analgesia at delivery, prolonged labour, forceps-assisted and vacuum-assisted delivery, parity, period of delivery and maternal age in multivariable analyses, the adjusted odds ratios for shoulder dystocia were 1.77 (1.42-2.20) for deliveries at 32-35 weeks of gestation, and 0.84 (0.79-0.88) at 42-43 weeks of gestation, using weeks 40-41 as the reference. In pregnancies affected by diabetes (n = 11,188), the incidence of shoulder dystocia was 3.95%, and after adjustment for birthweight the adjusted odds ratio for shoulder dystocia was 2.92 (95% CI 1.54-5.52) for deliveries at weeks 32-35 of gestation, and 0.91 (95% CI 0.50-1.66) at 42-43 weeks of gestation. The risk of shoulder dystocia was associated with increased birthweight, diabetes, induction of labour, use of epidural analgesia at delivery, prolonged labour, forceps-assisted and vacuum-assisted delivery, parity and period of delivery but not with post-term delivery. © 2013 Royal College of Obstetricians and Gynaecologists.

Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells.

Directory of Open Access Journals (Sweden)

Sanne Hindriksen

Full Text Available The CRISPR/Cas9 system is a highly effective tool for genome editing. Key to robust genome editing is the efficient delivery of the CRISPR/Cas9 machinery. Viral delivery systems are efficient vehicles for the transduction of foreign genes but commonly used viral vectors suffer from a limited capacity in the genetic information they can carry. Baculovirus however is capable of carrying large exogenous DNA fragments. Here we investigate the use of baculoviral vectors as a delivery vehicle for CRISPR/Cas9 based genome-editing tools. We demonstrate transduction of a panel of cell lines with Cas9 and an sgRNA sequence, which results in efficient knockout of all four targeted subunits of the chromosomal passenger complex (CPC. We further show that introduction of a homology directed repair template into the same CRISPR/Cas9 baculovirus facilitates introduction of specific point mutations and endogenous gene tags. Tagging of the CPC recruitment factor Haspin with the fluorescent reporter YFP allowed us to study its native localization as well as recruitment to the cohesin subunit Pds5B.

Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells.

Science.gov (United States)

Hindriksen, Sanne; Bramer, Arne J; Truong, My Anh; Vromans, Martijn J M; Post, Jasmin B; Verlaan-Klink, Ingrid; Snippert, Hugo J; Lens, Susanne M A; Hadders, Michael A

2017-01-01

The CRISPR/Cas9 system is a highly effective tool for genome editing. Key to robust genome editing is the efficient delivery of the CRISPR/Cas9 machinery. Viral delivery systems are efficient vehicles for the transduction of foreign genes but commonly used viral vectors suffer from a limited capacity in the genetic information they can carry. Baculovirus however is capable of carrying large exogenous DNA fragments. Here we investigate the use of baculoviral vectors as a delivery vehicle for CRISPR/Cas9 based genome-editing tools. We demonstrate transduction of a panel of cell lines with Cas9 and an sgRNA sequence, which results in efficient knockout of all four targeted subunits of the chromosomal passenger complex (CPC). We further show that introduction of a homology directed repair template into the same CRISPR/Cas9 baculovirus facilitates introduction of specific point mutations and endogenous gene tags. Tagging of the CPC recruitment factor Haspin with the fluorescent reporter YFP allowed us to study its native localization as well as recruitment to the cohesin subunit Pds5B.

HIV-1 gp120 neurotoxicity proximally and at a distance from the point of exposure: protection by rSV40 delivery of antioxidant enzymes.

Science.gov (United States)

Louboutin, Jean-Pierre; Agrawal, Lokesh; Reyes, Beverly A S; Van Bockstaele, Elisabeth J; Strayer, David S

2009-06-01

Toxicity of HIV-1 envelope glycoprotein (gp120) for substantia nigra (SN) neurons may contribute to the Parkinsonian manifestations often seen in HIV-1-associated dementia (HAD). We studied the neurotoxicity of gp120 for dopaminergic neurons and potential neuroprotection by antioxidant gene delivery. Rats were injected stereotaxically into their caudate-putamen (CP); CP and (substantia nigra) SN neuron loss was quantified. The area of neuron loss extended several millimeters from the injection site, approximately 35% of the CP area. SN neurons, outside of this area of direct neurotoxicity, were also severely affected. Dopaminergic SN neurons (expressing tyrosine hydroxylase, TH, in the SN and dopamine transporter, DAT, in the CP) were mostly affected: intra-CP gp120 caused approximately 50% DAT+ SN neuron loss. Prior intra-CP gene delivery of Cu/Zn superoxide dismutase (SOD1) or glutathione peroxidase (GPx1) protected SN neurons from intra-CP gp120. Thus, SN dopaminergic neurons are highly sensitive to HIV-1 gp120-induced neurotoxicity, and antioxidant gene delivery, even at a distance, is protective.

Acquiring Consumer Trust: Minimizing the GAP Between Environmental Concern and Environmental Consumption

Directory of Open Access Journals (Sweden)

Elias Frederico

2013-12-01

Full Text Available Environmental management has become an important managerial tool for creating conditions for greater competitiveness of organizations. A significant portion of the population considers environmental issues while consuming. However, despite the proposed relationship between environmental concern and consumption, some studies have identified a gap between declared environmental concern and consumer behavior. One possible explanation for this gap is the lack of trust in the ethics of retailers and the perception that environmental appealing offers would be only artifices of marketing. Thus, this paper aims to analyze the moderating effect of trust in the relationship between Environmental concern and environmental purchase intention. To operationalize the study, an online survey was conducted among 696 Brazilian consumers. The sample was characterized as non-probabilistic. Validated scales were used to measure the variables and data were analyzed using structural equation modeling. The results show that there is a significant relationship between environmental concern and environmental purchase intention, however, the low explanatory power of the model points to the gap between discourse and practice. By analyzing the trust of consumers as moderating variable, it is clear that, by increasing consumers’ trust, the gap between environmental concern and consumption is diminished.

Utilization of institutional delivery service and associated factors in Bench Maji zone, Southwest Ethiopia: community based, cross sectional study.

Science.gov (United States)

Tadele, Niguse; Lamaro, Tafesse

2017-02-01

At the end of Millennium development goals, Ethiopia was included among 10 countries which constitutes about 59% of maternal deaths due to complications of pregnancy and/or childbirth every year globally. Institutional delivery, which is believed to contribute in reduction of maternal mortality is still low. Hence this study was conducted in order to assess utilization of institutional delivery and related factors in Bench Maji zone, Southwest Ethiopia. Cross sectional study was employed from September 1st - 30th, 2015 in Bench Maji Zone, Southwest Ethiopia where 765 mothers who deliver 2 years preceding the study provided data for this research. Data were collected by enumerators who were trained. In addition to descriptive statistics, binary and multivariate logistic regression analyses were performed. Statistical significance was considered at a p-value delivery which was significant. In Bench Maji Zone institutional delivery was shown to be comparatively good compared to other studies in the region and in Ethiopia in general even though it is below the health sector transformation plan of Ethiopia which aimed to increase deliveries attended by skilled health personnel to 95%. Empowering women, increasing awareness about institutional delivery and proper scaling up of antenatal care services which is an entry point for institutional delivery are recommended.

Effect of bond administration on construction project delivery

Directory of Open Access Journals (Sweden)

Oke Ayodeji Emmanuel

2016-12-01

Full Text Available Construction bond administration involves management of bond issues from inception of obtaining bond from guarantor to the point of release of contractor by the client. This process has posted a lot of challenges to construction stakeholders; it is therefore, necessary to examine the relationship between bond administration and project success. Archival data of completed bonded building projects were gathered through a pro forma developed for this purpose. Using Pearson product moment of correlation, it was revealed that the cost of securing a construction bond has a positive and significant effect on the initial and final costs of the project, while the number of days needed to secure a construction bond has no significant effect on the initial and final durations of the construction project. In order to establish the relationship between project delivery indices of cost and time and the construction bond administration variables, iteration of linear regression was adopted to arrive at the best-fit equation. Factors affecting the cost of securing construction bonds from guarantors should be identified and given adequate attention by construction stakeholders in order to minimize the effect of construction bond administration on project delivery.

Integration of Environmental Aspects in Tourism Higher Education: the Hotel Managers’ Point of View

Directory of Open Access Journals (Sweden)

Gul Gunes

2012-10-01

Full Text Available Our environment and our society is continually dynamic. Courses such as hotel management, hygiene, food and beverage, front office are essential for the tourism sector. Besides, concern for environmental issues is one of the key components of higher education for tourism. This study presents a critical review of environmental aspects in higher education for tourism in Turkey. Because the demand for vocational schools (two-year colleges is more than that for faculties, there are more vocational schools than four-year faculties in Turkey. Their curriculum was researched and determined to lessons about the environment. In the scope of this study; a questionnaire was conducted on managers of blue flag hotels to learn their opinion about the sector. According to these reviews, the importance of environmental education in higher education was emphasized.

Vaginal Birth After Cesarean Delivery: Deciding on a Trial of Labor After a Cesarean Delivery (TOLAC)

Science.gov (United States)

f AQ FREQUENTLY ASKED QUESTIONS FAQ070 LABOR, DELIVERY, AND POSTPARTUM CARE Vaginal Birth After Cesarean Delivery • What is a vaginal birth after cesarean delivery (VBAC)? • What is a trial of labor ...

Predicted erosion and sediment delivery of fallout plutonium

International Nuclear Information System (INIS)

Foster, G.R.; Hakonson, T.E.

1984-01-01

Plutonium (Pu) from fallout after atmospheric explosion of nuclear weapons in the 1950s and 1960s is being redistributed over the landscape by soil erosion and carried on sediment by streams to oceans. Erosion rates computed with the Universal Soil Loss Equation for about 200,000 sample points on nonfederal land across the US were used to estimate Pu removal rates by soil erosion by water, Pu delivery in several major rivers, and concentration of Pu on the transported sediment. Estimates of average annual Pu delivery on sediment ranged from 0.002% of the initial fallout Pu inventory for the Savannah River basin to 0.08% for the Mississippi River basin. If the deposition of Pu had been uniformly 37 Bq/m 2 , the estimated Pu activity on suspended sediment ranged from about 0.26 Bq/kg of sediment for the Savannah River basin to 0.52 Bq/kg for the Columbia and Rio Grande river basins. After 1000 yr, about 9 to 48% of the initial Pu inventory will remain in US soils that are eroding. Much of the Pu on eroded sediment will travel only a short distance from its origin before its host sediment particles are deposited and permanently located, at least for a few hundred years. As much as 90% of the initially deposited Pu will remain, redistributed over the landscape by erosion and deposition. Although the delivery rate of Pu by rivers will not decrease greatly in the next 100 yr, a significant decrease will likely occur by 1000 yr

Environmental radiological protection of Bariloche Atomic Center

International Nuclear Information System (INIS)

Andres, Pablo A.; Levanon, Izhar S.

2013-01-01

This plan of monitoring radiological environmental routine fits on environmental policy of CNEA, satisfying national and international recommendations for licensed facilities. Sampling matrices are related to direct routes of exposure: air and water (river, lake, sediments, drinking water). Soil samples are also analyzed for having integrated matrices. They are considered as minimum three points of measurement: a white point (water or winds up), a point of maximum (water or winds down) and a point corresponding to the location of the individual representative or a point of public interest. Measurements in air estimate KERMA rate with thermoluminescent dosimeters, bi-monthly, and concentrations of particulate material and aerosols. For water samples (monthly), soil and sediments (quarterly), radionuclides that have download limits are analyzed, according to its importance in the dosages produced in the representative individual. In these cases artificial radionuclides using gamma spectrometry, beta total and Sr-90 by radiochemical techniques if the value of total screening (1 Bq/L) is exceeded. Foods are not included because no possible matrices were detected, either by their distance. by located not predominant wind direction. They are however still looking for milk producers that fulfills the minimum requirements.The data collected are compared with environmental baselines to set trends that might point to future significant changes in the environment during the life of the facilities. So far it was not observed significant differences with respect to baseline values

Environmental charges in airline markets

Energy Technology Data Exchange (ETDEWEB)

Carlsson, Fredrik [Goeteborg Univ., Dept. of Economics, Goeteborg (Sweden)

2002-07-01

Over the last two decades many airline markets have been deregulated, resulting in increased competition and use of different types of networks. At the same time there has been an intense discussion on environmental taxation of airline traffic. It is likely that an optimal environmental charge and the effects of a charge differ between different types of aviation markets. In this paper, we derive optimal flight (environmental) charges for different types of airline markets. The first type of market is a multiproduct monopoly airline operating either a point-to-point network or a hub-and-spoke network. The optimal charge is shown to be similar in construction to an optimal charge for a monopolist. We also compare the environmental impact of the two types of networks. Given no differences in marginal damages between airports we find that an airline will always choose the network with the highest environmental damages. The second type of market we investigate is a multiproduct duopoly, where two airlines compete in both passengers and flights. The formulation of the optimal charge is similar to the optimal charge of a single product oligopoly. However, we also show that it is, because of strategic effects, difficult to determine the effects of the charge on the number of flights. (Author)

Floating Microparticulate Oral Diltiazem Hydrochloride Delivery ...

African Journals Online (AJOL)

Delivery System for Improved Delivery to Heart ... Conclusion: Microparticulate floating (gastroretentive) oral drug delivery system of diltiazem prepared ..... treatment of cardiac disease. ... hydrochloride-loaded mucoadhesive microspheres.

Remotely-sensed, nocturnal, dew point correlates with malaria transmission in Southern Province, Zambia: a time-series study.

Science.gov (United States)

Nygren, David; Stoyanov, Cristina; Lewold, Clemens; Månsson, Fredrik; Miller, John; Kamanga, Aniset; Shiff, Clive J

2014-06-13

Plasmodium falciparum transmission has decreased significantly in Zambia in the last decade. The malaria transmission is influenced by environmental variables. Incorporation of environmental variables in models of malaria transmission likely improves model fit and predicts probable trends in malaria disease. This work is based on the hypothesis that remotely-sensed environmental factors, including nocturnal dew point, are associated with malaria transmission and sustain foci of transmission during the low transmission season in the Southern Province of Zambia. Thirty-eight rural health centres in Southern Province, Zambia were divided into three zones based on transmission patterns. Correlations between weekly malaria cases and remotely-sensed nocturnal dew point, nocturnal land surface temperature as well as vegetation indices and rainfall were evaluated in time-series analyses from 2012 week 19 to 2013 week 36. Zonal as well as clinic-based, multivariate, autoregressive, integrated, moving average (ARIMAX) models implementing environmental variables were developed to model transmission in 2011 week 19 to 2012 week 18 and forecast transmission in 2013 week 37 to week 41. During the dry, low transmission season significantly higher vegetation indices, nocturnal land surface temperature and nocturnal dew point were associated with the areas of higher transmission. Environmental variables improved ARIMAX models. Dew point and normalized differentiated vegetation index were significant predictors and improved all zonal transmission models. In the high-transmission zone, this was also seen for land surface temperature. Clinic models were improved by adding dew point and land surface temperature as well as normalized differentiated vegetation index. The mean average error of prediction for ARIMAX models ranged from 0.7 to 33.5%. Forecasts of malaria incidence were valid for three out of five rural health centres; however, with poor results at the zonal level. In this

Environmental Criteria in the Spanish Public Works Procurement Process

Directory of Open Access Journals (Sweden)

José Luis Fuentes-Bargues

2017-02-01

Full Text Available Green Public Procurement (GPP is defined as a process of contracting products, services, and works with the least possible damage to the environment during their life cycle. In order to improve the knowledge about GPP, a study of the use of environmental tendering criteria in the Spanish public construction sector has been performed. The results of this study show that the use of environmental criteria in Spanish public sector construction procurement is low in comparison to a certain group of countries, known as “Green 7”, in the European Union. Environmental criteria is the fourth criterion in importance, but its weight in the global of the process is much lower than other criteria such as price, memory of the construction process and the delivery time. National administrations use environmental criteria more frequently because they have more resources and staff training about environmental issues. Environmental criteria are more used in the tendering of civil projects and works whose budget exceeds ten million euro due to the environmental impact of these kind and/or size of projects.

Feed-Back Moisture Sensor Control for the Delivery of Water to Plants Cultivated in Space

Science.gov (United States)

Levine, Howard G.; Prenger, Jessica J.; Rouzan, Donna T.; Spinale, April C.; Murdoch, Trevor; Burtness, Kevin A.

2005-01-01

The development of a spaceflight-rated Porous Tube Insert Module (PTIM) nutrient delivery tray has facilitated a series of studies evaluating various aspects of water and nutrient delivery to plants as they would be cultivated in space. We report here on our first experiment using the PTIM with a software-driven feedback moisture sensor control strategy for maintaining root zone wetness level set-points. One-day-old wheat seedlings (Tritium aestivum cv Apogee; N=15) were inserted into each of three Substrate Compartments (SCs) pre-packed with 0.25-1 . mm Profile(TradeMark) substrate and maintained at root zone relative water content levels of 70, 80 and 90%. The SCs contained a bottom-situated porous tube around which a capillary mat was wrapped. Three Porous Tubes. were planted using similar protocols (but without the substrate) and also maintained at these three moisture level set-points. Half-strength modified Hoagland's nutrient solution was used to supply water and nutrients. Results on hardware performance, water usage rates and wheat developmental differences between the different experimental treatments are presented.

Service Matters: Single Service Point as a Collaborative and Professional Learning Initiative for Service Excellence

Science.gov (United States)

Chauvet, Marianne; Bourbous, Vicki; Liston, Frances

2016-01-01

Changes and innovations in higher education learning and teaching acted as a catalyst for rethinking the way in which service was delivered to library clients at Australian Catholic University. The Single Service Point was piloted at one campus library in 2014 to develop a best practice approach to service delivery. The merging of cultures within…

77 FR 4989 - Turning Point Solar LLC: Notice of Availability of an Environmental Assessment

Science.gov (United States)

2012-02-01

... monocrystalline photovoltaic panels mounted on fixed solar racking equipment and the construction of access roads... DEPARTMENT OF AGRICULTURE Rural Utilities Service Turning Point Solar LLC: Notice of Availability... possible financial assistance for a proposal by Turning Point Solar LCC (TPS). The proposal consists of...

77 FR 41182 - Northwest Pipeline GP; Notice of Intent To Prepare an Environmental Assessment for the Proposed...

Science.gov (United States)

2012-07-12

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP12-471-000] Northwest Pipeline GP; Notice of Intent To Prepare an Environmental Assessment for the Proposed South Seattle Delivery Lateral Expansion Project, Request for Comments on Environmental Issues, and Notice of Public Scoping Meeting The staff of the Federal Energy...

Drug delivery device including electrolytic pump

KAUST Repository

Foulds, Ian G.; Buttner, Ulrich; Yi, Ying

2016-01-01

Systems and methods are provided for a drug delivery device and use of the device for drug delivery. In various aspects, the drug delivery device combines a “solid drug in reservoir” (SDR) system with an electrolytic pump. In various aspects an improved electrolytic pump is provided including, in particular, an improved electrolytic pump for use with a drug delivery device, for example an implantable drug delivery device. A catalytic reformer can be incorporated in a periodically pulsed electrolytic pump to provide stable pumping performance and reduced actuation cycle.

Drug delivery device including electrolytic pump

KAUST Repository

Foulds, Ian G.

2016-03-31

Systems and methods are provided for a drug delivery device and use of the device for drug delivery. In various aspects, the drug delivery device combines a “solid drug in reservoir” (SDR) system with an electrolytic pump. In various aspects an improved electrolytic pump is provided including, in particular, an improved electrolytic pump for use with a drug delivery device, for example an implantable drug delivery device. A catalytic reformer can be incorporated in a periodically pulsed electrolytic pump to provide stable pumping performance and reduced actuation cycle.

Early elective cesarean delivery before 36 weeks vs late spontaneous delivery in infants with gastroschisis.

Science.gov (United States)

Hadidi, Ahmed; Subotic, Ulrike; Goeppl, Maximilian; Waag, Karl-L

2008-07-01

The aim of this study is to assess the value of early elective cesarean delivery for patients with gastroschisis in comparison with late spontaneous delivery. Analysis of infants with gastroschisis admitted between 1986 and 2006 at a tertiary care center was performed. The findings were analyzed statistically. Eighty-six patients were involved in the study. This included 15 patients who underwent emergency cesarean delivery (EM CD group) because of fetal distress and/or bowel ischemia. The remaining 71 patients born electively were stratified into 4 groups. The early elective cesarean delivery (ECD) group included 23 patients born by ECD before 36 weeks; late vaginal delivery (LVD) group included 23 patients who had LVD after 36 weeks; 24 patients had LCD after 36 weeks because of delayed diagnosis that resulted in late referral; and 1 patient had early spontaneous vaginal delivery (EVD group) before 36 weeks. The mean time to start oral feeding, incidence of complications, and primary closure were significantly better in the ECD group than in the LVD group. The duration of ventilation and the length of stay were shorter in ECD group, but the difference was not statistically significant. Elective cesarean delivery before 36 weeks allows earlier enteral feeding and is associated with less complications and higher incidence of primary closure (statistically significant).

Environmental noise pollution and risk of preeclampsia.

Science.gov (United States)

Auger, Nathalie; Duplaix, Mathilde; Bilodeau-Bertrand, Marianne; Lo, Ernest; Smargiassi, Audrey

2018-08-01

Environmental noise exposure is associated with a greater risk of hypertension, but the link with preeclampsia, a hypertensive disorder of pregnancy, is unclear. We sought to determine the relationship between environmental noise pollution and risk of preeclampsia during pregnancy. We analyzed a population-based cohort comprising 269,263 deliveries on the island of Montreal, Canada between 2000 and 2013. We obtained total environmental noise pollution measurements (LA eq24 , L den , L night ) from land use regression models, and assigned noise levels to each woman based on the residential postal code. We computed odds ratios (OR) and 95% confidence intervals (CI) for the association of noise with preeclampsia in mixed logistic regression models with participants as a random effect, and adjusted for air pollution, neighbourhood walkability, maternal age, parity, multiple pregnancy, comorbidity, socioeconomic deprivation, and year of delivery. We assessed whether noise exposure was more strongly associated with severe or early onset preeclampsia than mild or late onset preeclampsia. Prevalence of preeclampsia was higher for women exposed to elevated environmental noise pollution levels (LA eq24h  ≥ 65 dB(A) = 37.9 per 1000 vs. <50 dB(A) = 27.9 per 1000). Compared with 50 dB(A), an LA eq24h of 65.0 dB(A) was not significantly associated the risk of preeclampsia (OR 1.09, 95% CI 0.99-1.20). Associations were however present with severe (OR 1.29, 95% CI 1.09-1.54) and early onset (OR 1.71, 95% CI 1.20-2.43) preeclampsia, with results consistent across all noise indicators. The associations were much weaker or absent for mild and late preeclampsia. Environmental noise pollution may be a novel risk factor for pregnancy-related hypertension, particularly more severe variants of preeclampsia. Copyright © 2018 Elsevier Ltd. All rights reserved.

Design of environmentally friendly products using indicators

DEFF Research Database (Denmark)

Lenau, Torben Anker; Bey, Niki

2001-01-01

The paper describes the requirements of product designers towards methods for environmental evaluation; it argues that indicators can be used for rough environmental evaluations and it presents experiences made with the indicator-based Oil Point Method (OPM). This method is illustrated by means...

[Evaluation of changes in the mode of twin deliveries over the years].

Science.gov (United States)

Madej, Anna; Szymusik, Iwona; Oledzka, Magdalena; Kosińska-Kaczyńska, Katarzyna; Bomba-Opoń, Dorota A; Wielgoś, Mirosław

2012-10-01

The aim of the study was to evaluate changes in the course of twin deliveries over the years, with particular emphasis on the history of infertility duration of pregnancy mode of delivery indications for caesarean section (CS) and infant condition. The study consisted of three groups of patients who delivered twins at the First Department of Obstetrics & Gynecology Medical University of Warsaw: 92 women in years 1987-1991 (G1), 62 in years 1997-2001 (G2) and 126 in years 2007-2010 (G3). The history of infertility treatment (especially in vitro fertilization), mode of delivery indications for cesarean section and newborn condition were taken into account. The results were afterwards compared among the groups and the differences were analyzed with the use of Statistica 10.0 software, with p value Manual maneuvers on the 2nd twins were applied in 25% vs. 6.5% vs. 0.79% of deliveries (pApgar scores of the first twins in the 1st and 5th minute of life among the studied groups. However, second twins were delivered in significantly better condition in G2 and G3 than in G1 (5-minute Apgar of 8-10 points: 79.7% vs. 93.3% vs. 92.6%; p<0.05). Twin pregnancy rate almost doubled over the years, mostly due to a growing popularity of the infertility treatment. Cesarean section is increasingly being chosen to deliver twins. The non-cephalic position of the 2nd fetus has become an important indication for cesarean section. Change in the mode of twin deliveries can be beneficial for the condition of the 2nd twin.

A comparison of groundwater investigation using temporary points versus permanent monitoring wells

International Nuclear Information System (INIS)

Thompson, N.T.

1994-01-01

Groundwater investigation within the environmental industry is most often conducted using permanent monitoring wells. A monitoring well, as the term suggests, is permanent to the extent that it is fixed in place to monitor groundwater quality in its immediate vicinity at any given time over the course of an environmental project. Because monitoring wells are relatively time consuming and expensive to construct, a minimum number of wells is normally installed as part of a single investigation event. The initial information obtained from monitoring wells could also be obtained from temporary groundwater sampling points. Temporary points generally are smaller in diameter than monitoring wells, are installed to provide a one time snap shot of the subsurface, and are removed at the completion of the investigation. Since temporary points are usually easier to install and less expensive than monitoring wells, more temporary points can be installed over a single investigation event and can often reduce or eliminate subsequent assessment(s). A brief discussion of temporary point installation and sampling is offered before considering two case studies within the context of the above advantages to temporary point installation. One case study focuses on vertical delineation of dissolved petroleum hydrocarbons, while the second case study discusses lateral delineation of light nonaqueous phase liquid (LNAPL)

Environmental analysis in small and medium enterprises

International Nuclear Information System (INIS)

Luciani, R.; Andriola, L.; Di Franco, N.

2001-01-01

An environmental analysis is considered to be one of the primary goals for an enterprise environmental management. Nevertheless the complexity of the environmental problems and of its regulations prevents the small enterprises the possibility to perform an environmental policy (EMAS, ISO 14001). One of the most correct evaluation instrument for creating a datum-point standard could be the filling up a questionnaire, built up in according to the industrial enterprises need. It has the function of creating a primary step for a subsequent environmental management [it

[The development of novel tumor targeting delivery strategy].

Science.gov (United States)

Gao, Hui-le; Jiang, Xin-guo

2016-02-01

Tumor is one of the most serious threats for human being. Although many anti-tumor drugs are approved for clinical use, the treatment outcome is still modest because of the poor tumor targeting efficiency and low accumulation in tumor. Therefore, it is important to deliver anti-tumor drug into tumor efficiently, elevate drug concentration in tumor tissues and reduce the drug distribution in normal tissues. And it has been one of the most attractive directions of pharmaceutical academy and industry. Many kinds of strategies, especially various nanoparticulated drug delivery systems, have been developed to address the critical points of complex tumor microenvironment, which are partially or mostly satisfied for tumor treatment. In this paper, we carefully reviewed the novel targeting delivery strategies developed in recent years. The most powerful method is passive targeting delivery based on the enhanced permeability and retention(EPR) effect, and most commercial nanomedicines are based on the EPR effect. However, the high permeability and retention require different particle sizes, thus several kinds of size-changeable nanoparticles are developed, such as size reducible particles and assemble particles, to satisfy the controversial requirement for particle size and enhance both tumor retention and penetration. Surface charge reversible nanoparticles also shows a high efficiency because the anionic charge in blood circulation and normal organs decrease the unintended internalization. The charge can change into positive in tumor microenvironment, facilitating drug uptake by tumor cells. Additionally, tumor microenvironment responsive drug release is important to decrease drug side effect, and many strategies are developed, such as p H sensitive release and enzyme sensitive release. Except the responsive nanoparticles, shaping tumor microenvironment could attenuate the barriers in drug delivery, for example, decreasing tumor collagen intensity and normalizing tumor

Role of environmental variables on radon concentration in soil

International Nuclear Information System (INIS)

Climent, H.; Bakalowicz, M.; Monnin, M.

1998-01-01

In the frame of an European project, radon concentrations in soil and measurements of environmental variables such as the nature of the soil or climatic variables were monitored. The data have been analysed by time-series analysis methods, i.e. Correlation and Spectrum Analysis, to point out relations between radon concentrations and some environmental variables. This approach is a compromise between direct observation and modelling. The observation of the rough time series is unable to point out the relation between radon concentrations and an environmental variable because of the overlapping of the influences of several variables, and the time delay induced by the medium. The Cross Spectrum function between the time series of radon and of an environmental variable describes the nature of the relation and gives the response time in the case of a cause to effect relation. It requires the only hypothesis that the environmental variable is the input function and radon concentration the output function. This analysis is an important preliminary study for modelling. By that way the importance of soil nature has been pointed out. The internal variables of the medium (permeability, porosity) appear to restrain the influence of the environmental variables such as humidity, temperature or atmospheric pressure. (author)

Augmented Citizen Science for Environmental Monitoring and Education

Science.gov (United States)

Albers, B.; de Lange, N.; Xu, S.

2017-09-01

Environmental monitoring and ecological studies detect and visualize changes of the environment over time. Some agencies are committed to document the development of conservation and status of geotopes and geosites, which is time-consuming and cost-intensive. Citizen science and crowd sourcing are modern approaches to collect data and at the same time to raise user awareness for environmental changes. Citizen scientists can take photographs of point of interests (POI) with smartphones and the PAN App, which is presented in this article. The user is navigated to a specific point and is then guided with an augmented reality approach to take a photo in a specific direction. The collected photographs are processed to time-lapse videos to visualize environmental changes. Users and experts in environmental agencies can use this data for long-term documentation.

The environmental impact of civil conflict The deforestation effect of paramilitary expansion in Colombia

OpenAIRE

Leopoldo Fergussony Dario Romeroz Juan F. Vargas

2013-01-01

Despite a growing body of literature on how environmental degradation can fuel civil war, the reverse effect, namely that of conflict on environmental outcomes, is relatively understudied. From a theoretical point of view, this effect is ambiguous, with some forces pointing to pressures for environmental degradation and some pointing in the opposite direction. Hence, the overall effect of conflict on the environment is an empirical question. We study this relationship in the case of Colombia....

The environmental impact of civil conflict : the deforestation effect of paramilitary expansion in Colombia

OpenAIRE

Fergusson Talero, Leopoldo; Mendoza Romero, Dario; Vargas, Juan Fernando

2014-01-01

Despite a growing body of literature on how environmental degradation can fuel civil war, the reverse effect, namely that of conflict on environmental outcomes, is relatively understudied. From a theoretical point of view this effect is ambiguous, with some forces pointing to pressures for environmental degradation and some pointing in the opposite direction. Hence, the overall effect of conflict on the environment is an empirical question. We study this relationship in the case of Colombia. ...

Characteristics of teaching environmental education in primary schools

OpenAIRE

Stanišić, Jelena M.

2016-01-01

The results of the recent research in the field of environmental education point to the fact that it is not enough to incorporate environmental content in the curricula and expect the students to behave environmentally responsibly. This is only a small step on the long and complex path of developing environmental awareness. Apart from the fact that environmental issues are included in the curricula, it is very important how these environmental issues are conveyed to students. The aim of this ...

Creating the Data Basis for Environmental Evaluations with the Oil Point Method

DEFF Research Database (Denmark)

Bey, Niki; Lenau, Torben Anker

1999-01-01

In order to support designers in decision-making, some methods have been developed which are based on environmental indicators. These methods, however, can only be used, if indicators for the specific product concept exist and are readily available.Based on this situation, the authors developed a...

"Who Polluted the Potomac?" The Translation and Implementation of a US Environmental Story in Brazilian and Turkish Classrooms

Science.gov (United States)

Oliveira, Alandeom W.; Colak, Huseyin; Akerson, Valarie L.

2009-01-01

In this study we examine how elementary teachers in Brazil and Turkey approached the translation and subsequent classroom implementation of an instructional activity that promotes environmental awareness through a combination of student role playing and teacher oral delivery of an environmental story about river pollution. A discourse analysis…

77 FR 32626 - Transcontinental Gas Pipe Line Company, LLC; Notice of Intent To Prepare an Environmental Impact...

Science.gov (United States)

2012-06-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PF09-8-000] Transcontinental Gas Pipe Line Company, LLC; Notice of Intent To Prepare an Environmental Impact Statement for the Planned Rockaway Delivery Lateral Project, Request for Comments on Environmental Issues, and Notice of Public Scoping Meetings The staff of the Federa...

New England observed and predicted median July stream/river temperature points

Data.gov (United States)

U.S. Environmental Protection Agency — The shapefile contains points with associated observed and predicted median July stream/river temperatures in New England based on a spatial statistical network...

New England observed and predicted median August stream/river temperature points

Data.gov (United States)

U.S. Environmental Protection Agency — The shapefile contains points with associated observed and predicted median August stream/river temperatures in New England based on a spatial statistical network...

Socio-Environmental Health Analysis in Nogales, Sonora, Mexico.

Science.gov (United States)

Norman, Laura M; Caldeira, Felipe; Callegary, James; Gray, Floyd; O' Rourke, Mary Kay; Meranza, Veronica; Van Rijn, Saskia

2012-06-01

In Nogales, Sonora, Mexico, some neighborhoods, or colonias, have intermittent delivery of water through pipes from the city of Nogales's municipal water-delivery system while other areas lack piped water and rely on water delivered by truck or pipas. This research examined how lifestyles, water quality, and potential disease response, such as diarrhea, differs seasonally from a colonia with access to piped water as opposed to one using alternative water-delivery systems. Water samples were collected from taps or spigots at homes in two Nogales colonias. One colonia reflected high socio-environmental conditions where residents are supplied with municipal piped water (Colonia Lomas de Fatima); the second colonia reflected low socio-environmental conditions, lacking access to piped water and served by pipas (Colonia Luis Donaldo Colosio). A survey was developed and implemented to characterize perceptions of water quality, health impacts, and quality of life. Water samples were analyzed for microbial and inorganic water-quality parameters known to impact human health including, Escherichia coli (E. coli), total coliform bacteria, arsenic, and lead. A total of 21 households agreed to participate in the study (14 in Colosio and 7 in Fatima). In both colonias metal concentrations from water samples were all well below the United States Environmental Protection Agency's (US EPA's) maximum contaminant levels. E. coli concentrations exceeded the US EPA's drinking-water standard in Colosio but not Fatima. Total coliform bacteria were present in over 50 % of households in both colonias. Microbial contamination was significantly higher in the summer than in the winter in both colonias. Resulting analysis suggests that residents in colonias without piped water are at a greater risk of gastrointestinal illness from consumption of compromised drinking water. Our survey corroborated reports of gastrointestinal illness in the summer months but not in the winter. Chloride was found

Engineering assessment of inactive uranium mill tailings, Ray Point Site, Ray Point, Texas. Phase II, Title I

International Nuclear Information System (INIS)

1977-12-01

Results are reported from an engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at Ray Point, Texas. The Phase II--Title I services generally include the preparation of topographic maps, the performance of soil sampling and radiometric measurements sufficient to determine areas and volumes of tailings and other radium-contaminated materials, the evaluation of resulting radiation exposures of individuals and nearby populations, the investigation of site hydrology and meteorology and the evaluation and costing of alternative corrective actions. About 490,000 tons of ore were processed at this mill with all of the uranium sold on the commercial market. None was sold to the AEC; therefore, this report focuses on a physical description of the site and the identification of radiation pathways. No remedial action options were formulated for the site, inasmuch as none of the uranium was sold to the AEC and Exxon Corporation has agreed to perform all actions required by the State of Texas. Radon gas release from the tailings at the Ray Point site constitutes the most significant environmental impact. Windblown tailings, external gamma radiation and localized contamination of surface waters are other environmental effects. Exxon is also studying the feasibility of reprocessing the tailings

Bacterial membrane vesicles, an overlooked environmental colloid: Biology, environmental perspectives and applications.

Science.gov (United States)

Toyofuku, Masanori; Tashiro, Yosuke; Hasegawa, Yusuke; Kurosawa, Masaharu; Nomura, Nobuhiko

2015-12-01

Phospholipid vesicles play important roles in biological systems. Bacteria are one of the most abundant organisms on Earth, and bacterial membrane vesicles (MVs) were first observed 50 years ago. Many bacteria release MVs to the environment that mainly consist of the cell membrane and typically range from 20 to 400 nm in size. Bacterial MVs are involved in several biological functions, such as delivery of cargo, virulence and gene transfer. MVs can be isolated from laboratory culture and directly from the environment, indicating their high abundance in and impact on ecosystems. Many colloidal particles in the environment ranging in size from 1 nm to 1 μm have been reported but not characterized at the molecular level, and MVs remain to be explored. Hence, MVs can be considered terra incognita in environmental colloid research. Although MV biogenesis and biological roles are yet to be fully understood, the accumulation of knowledge has opened new avenues for their applications. Via genetic engineering, the MV yield can be greatly increased, and the components of MVs can be tailored. Recent studies have demonstrated that MVs have promising potential for applications such as drug delivery systems and nanobiocatalysts. For instance, MV vaccines have been extensively studied and have already been approved in Europe. Recent MV studies have evoked great interest in the fields of biology and biotechnology, but fundamental questions, such as their transport in the environment or physicochemical features of MVs, remain to be addressed. In this review, we present the current understanding of bacterial MVs and environmental perspectives and further introduce their applications. Copyright © 2015. Published by Elsevier B.V.

Environmental ethics and environmental policy

International Nuclear Information System (INIS)

Hoehn, H.J.

1994-01-01

In a difficult economic situation where the problems of many companies to adapt to changed economic conditions threaten to supersede ecological interests the Council of Experts appointed by the Federal Environment Minister submitted its 1994 environmental expertise. This scientific political counseling document would deserve little attention if it was limited to the appeal of considering pollution control as an integrated part of all political activities or if it only contained a catalog of measures for the ecological repair of technico-industrial faults and failures. The structural change of economy and the necessity of ecological modernization, however, are taken into account by representing an ecological-economic model which contributes to a long-term conceptional orientation of environmental policy and which is elaborate enough to be suited for the development of solutions to concrete problems. The main points of the expertise are discussed. (orig./UA) [de

The Influence of Air Temperature on the Dew Point Temperature in ...

African Journals Online (AJOL)

ADOWIE PERE

done to determine the influence and effect of temperature on other climatic environmental ... Key words: Air Temperature, Dew point temperature, Weather, Climate, Influence. Weather ... humidity, clouds and atmospheric pressure. Its.

Point of Maintenance Ruggedized Operational Device Evaluation and Observation Test Report

National Research Council Canada - National Science Library

Gorman, Megan

2002-01-01

.... The Ruggedized Operational Device Evaluation and Observation (RODEO) test examined hardware packaging, software user interface, and environmental factors associated with the usability of potential Point of Maintenance (POMx) electronic tools...

Point-of-care diagnostics: market trends and growth drivers.

Science.gov (United States)

Rajan, Aruna; Glorikian, Harry

2009-01-01

There is a significant demand for in vitro diagnostic (IVD) testing to move closer to the patient point-of-care diagnostics [POC]), whether in the hospital, physician's office, rapid clinic or the home, effectively cutting time to results and helping patients make better informed decisions about their health. To analyze the point-of-care market and its trends and growth drivers. In 2007, POC made up 30% of the IVD market and is expected to grow at 9% a year. Although the overall POC market is expected to grow steadily, infectious POC is now the most attractive segment. Availability of rapid random access molecular diagnostic system for critical care infectious diseases such as MRSA and sepsis in the near future is likely to be a significant driver of infectious POC post 2012. Owing to the extraordinary increase in the cost of care, healthcare delivery is moving to increasingly decentralized settings such as rapid clinics and the home, driven by point-of-care diagnostics that provide accurate and directional results. We are evolving from the analog testing world to the digital testing world, where diagnosis is exact and therapy can be administered and be predictably effective.

Reflecting on the delivery of a longitudinal coping intervention amongst junior national netball players.

Science.gov (United States)

Devonport, Tracey J; Lane, Andrew M

2009-06-01

Recent research suggests that appropriately-tailored interventions can assist adolescents enhance their coping skills (Frydenberg and Lewis, 2004). The present paper reflects upon the delivery of a longitudinal coping intervention utilized by junior national netball players. Reflection is focused on issues such as the rationale for the intervention, operational issues surrounding the delivery and management of the work. It is also focused on interpersonal issues relating to intervention implementation. We contend that being explicit about developmental and applied processes may enable theoretically sound and efficacious practices to be identified. In addition, unpacking operational issues related to delivery may assist applied sport and exercise psychologists in the development of related work. Key pointsThis paper exemplifies the potential benefits of reflective practice and offers an insight into the lessons learned during longitudinal applied research.We conclude that intervention-based research must accommodate the idiosyncrasies of an organization and requires the sport organisation to buy into the value of the work.Whilst thoughts and associations are offered, readers are encouraged to consider these and alternative associations.

Aleutian Islands Coastal Resources Inventory and Environmental Sensitivity Maps: VOLCANOS (Volcano Points)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains point locations of active volcanoes as compiled by Motyka et al., 1993. Eighty-nine volcanoes with eruptive phases in the Quaternary are...

Microfabrication for Drug Delivery

Science.gov (United States)

Koch, Brendan; Rubino, Ilaria; Quan, Fu-Shi; Yoo, Bongyoung; Choi, Hyo-Jick

2016-01-01

This review is devoted to discussing the application of microfabrication technologies to target challenges encountered in life processes by the development of drug delivery systems. Recently, microfabrication has been largely applied to solve health and pharmaceutical science issues. In particular, fabrication methods along with compatible materials have been successfully designed to produce multifunctional, highly effective drug delivery systems. Microfabrication offers unique tools that can tackle problems in this field, such as ease of mass production with high quality control and low cost, complexity of architecture design and a broad range of materials. Presented is an overview of silicon- and polymer-based fabrication methods that are key in the production of microfabricated drug delivery systems. Moreover, the efforts focused on studying the biocompatibility of materials used in microfabrication are analyzed. Finally, this review discusses representative ways microfabrication has been employed to develop systems delivering drugs through the transdermal and oral route, and to improve drug eluting implants. Additionally, microfabricated vaccine delivery systems are presented due to the great impact they can have in obtaining a cold chain-free vaccine, with long-term stability. Microfabrication will continue to offer new, alternative solutions for the development of smart, advanced drug delivery systems. PMID:28773770

Project W-521, waste feed delivery systems environmental permits and approvals plan

International Nuclear Information System (INIS)

TOLLEFSON, K.S.

1999-01-01

This document has been prepared to define the specific environmental requirements applicable to Project W-521. The document describes the permits and approvals necessary for the project to design, construct, and install planned upgrades, and provides a schedule of activities and provides cost estimates to complete the required permitting and approval activities

Protein nanoparticles for therapeutic protein delivery.

Science.gov (United States)

Herrera Estrada, L P; Champion, J A

2015-06-01

Therapeutic proteins can face substantial challenges to their activity, requiring protein modification or use of a delivery vehicle. Nanoparticles can significantly enhance delivery of encapsulated cargo, but traditional small molecule carriers have some limitations in their use for protein delivery. Nanoparticles made from protein have been proposed as alternative carriers and have benefits specific to therapeutic protein delivery. This review describes protein nanoparticles made by self-assembly, including protein cages, protein polymers, and charged or amphipathic peptides, and by desolvation. It presents particle fabrication and delivery characterization for a variety of therapeutic and model proteins, as well as comparison of the features of different protein nanoparticles.

Environmental quality and economic growth: Searching for environmental Kuznets curves for air and water pollutants in Africa

International Nuclear Information System (INIS)

Orubu, Christopher O.; Omotor, Douglason G.

2011-01-01

This study investigated the relationship between per capita income and environmental degradation in Africa, using longitudinal data on suspended particulate matter and organic water pollutants. The specific objective was to estimate environmental Kuznets curves for two indicators of environmental quality and to establish whether the estimated relationships conform to the inverted U-shape hypothesis. The results of the empirical investigation generally suggest the existence of an environmental Kuznets curve for suspended particulate matter. In the case of organic water pollutants, the evidence weighs more in favor of rising pollution as per capita income increases. The turning point levels of income established for the two indicators of environmental quality were however generally low, when compared to evidence from existing studies. On the face value, this suggests that African countries may be turning the corner of the environmental Kuznets curve, much faster, and at lower levels of income, much in line with the emerging idea of a 'revised environmental Kuznets curve'. The results also suggest that economic growth and rising incomes may matter in African countries in order to curb pollution from these pollutants, but more stringent policy measures, particularly at the industrial level would be required to curb environmental degradation from organic water pollutants. - Highlights: → The specific objective was to establish whether the relationships conform to the inverted U-shape hypothesis. → Evidence suggests the existence of an environmental Kuznets curve for suspended particulate matter. → The turning point levels of income established for the two indicators were however generally low. → We conclude that African countries may be turning the corner of the environmental Kuznets curve, much faster, and at lower levels of income.

Environmental quality and economic growth: Searching for environmental Kuznets curves for air and water pollutants in Africa

Energy Technology Data Exchange (ETDEWEB)

Orubu, Christopher O. [Department of Economics, Delta State University, Abraka (Nigeria); Omotor, Douglason G., E-mail: yomotor@yahoo.com [Department of Economics, Delta State University, Abraka (Nigeria)

2011-07-15

This study investigated the relationship between per capita income and environmental degradation in Africa, using longitudinal data on suspended particulate matter and organic water pollutants. The specific objective was to estimate environmental Kuznets curves for two indicators of environmental quality and to establish whether the estimated relationships conform to the inverted U-shape hypothesis. The results of the empirical investigation generally suggest the existence of an environmental Kuznets curve for suspended particulate matter. In the case of organic water pollutants, the evidence weighs more in favor of rising pollution as per capita income increases. The turning point levels of income established for the two indicators of environmental quality were however generally low, when compared to evidence from existing studies. On the face value, this suggests that African countries may be turning the corner of the environmental Kuznets curve, much faster, and at lower levels of income, much in line with the emerging idea of a 'revised environmental Kuznets curve'. The results also suggest that economic growth and rising incomes may matter in African countries in order to curb pollution from these pollutants, but more stringent policy measures, particularly at the industrial level would be required to curb environmental degradation from organic water pollutants. - Highlights: > The specific objective was to establish whether the relationships conform to the inverted U-shape hypothesis. > Evidence suggests the existence of an environmental Kuznets curve for suspended particulate matter. > The turning point levels of income established for the two indicators were however generally low. > We conclude that African countries may be turning the corner of the environmental Kuznets curve, much faster, and at lower levels of income.

Electrospun fibers of layered double hydroxide/biopolymer nanocomposites as effective drug delivery systems

Energy Technology Data Exchange (ETDEWEB)

Miao, Yue-E.; Zhu Hong; Chen Dan; Wang Ruiyu [State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433 (China); Tjiu, Weng Weei [Institute of Materials Research and Engineering, A-STAR (Agency for Science, Technology and Research), 3 Research Link, Singapore 117602 (Singapore); Liu Tianxi, E-mail: txliu@fudan.edu.cn [State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433 (China)

2012-06-15

. Highlights: Black-Right-Pointing-Pointer A new drug delivery system is developed by the combination of LDHs with electrospinning. Black-Right-Pointing-Pointer LDH-IBU nanoparticles are uniformly dispersed in the electrospun fibers even at a high loading level of 5 wt%. Black-Right-Pointing-Pointer The initial burst release problem in IBU/PCL fibers is remarkably weakened by using LDH-IBU. Black-Right-Pointing-Pointer IBU release rate from PLA-based systems is opposite to the case in PCL system.

Pectin-based colon-specific drug delivery

OpenAIRE

Shailendra Shukla; Deepak Jain; Kavita Verma; Shiddarth Verma

2011-01-01

Colon-specific drug delivery have a great importance in the delivery of drugs for the treatment of local colonic, as well as systemic diseases like Crohn′s disease, ulcerative colitis, colorectal cancer, amoebiasis, asthma, arthritis and inflammation which can be achieved by targeted delivery of drug to colon. Specific systemic absorption in the colon gave interesting possibilities for the delivery of protein and peptides. It contains relatively less proteolytic enzyme activities in the colon...

Environmental Labels and Declarations

DEFF Research Database (Denmark)

Frydendal, Jeppe; Hansen, Lisbeth; Bonou, Alexandra

2018-01-01

Based on the terminology and structure developed by the International Organization for Standardization, a description is given on the types of ecolabels that build on life cycle assessments. Focus is on type I labels that point out products and services with an overall environmental preferability...... of labelling, the use of ecolabels in marketing, and the way ecolabels help build a market for “greener products”. Type III labels—or Environmental Product Declarations—are also briefly described with indicative examples from the building sector, a declaration for office furniture, and an introduction is given...... to the European Commission’s programme for product—and organisational environmental footprints ....

Efficacy of a process improvement intervention on delivery of HIV services to offenders: a multisite trial.

Science.gov (United States)

Pearson, Frank S; Shafer, Michael S; Dembo, Richard; Del Mar Vega-Debién, Graciela; Pankow, Jennifer; Duvall, Jamieson L; Belenko, Steven; Frisman, Linda K; Visher, Christy A; Pich, Michele; Patterson, Yvonne

2014-12-01

We tested a modified Network for the Improvement of Addiction Treatment (NIATx) process improvement model to implement improved HIV services (prevention, testing, and linkage to treatment) for offenders under correctional supervision. As part of the Criminal Justice Drug Abuse Treatment Studies, Phase 2, the HIV Services and Treatment Implementation in Corrections study conducted 14 cluster-randomized trials in 2011 to 2013 at 9 US sites, where one correctional facility received training in HIV services and coaching in a modified NIATx model and the other received only HIV training. The outcome measure was the odds of successful delivery of an HIV service. The results were significant at the .05 level, and the point estimate for the odds ratio was 2.14. Although overall the results were heterogeneous, the experiments that focused on implementing HIV prevention interventions had a 95% confidence interval that exceeded the no-difference point. Our results demonstrate that a modified NIATx process improvement model can effectively implement improved rates of delivery of some types of HIV services in correctional environments.

Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity

Directory of Open Access Journals (Sweden)

John R. Speakman

2011-11-01

Full Text Available The close correspondence between energy intake and expenditure over prolonged time periods, coupled with an apparent protection of the level of body adiposity in the face of perturbations of energy balance, has led to the idea that body fatness is regulated via mechanisms that control intake and energy expenditure. Two models have dominated the discussion of how this regulation might take place. The set point model is rooted in physiology, genetics and molecular biology, and suggests that there is an active feedback mechanism linking adipose tissue (stored energy to intake and expenditure via a set point, presumably encoded in the brain. This model is consistent with many of the biological aspects of energy balance, but struggles to explain the many significant environmental and social influences on obesity, food intake and physical activity. More importantly, the set point model does not effectively explain the ‘obesity epidemic’ – the large increase in body weight and adiposity of a large proportion of individuals in many countries since the 1980s. An alternative model, called the settling point model, is based on the idea that there is passive feedback between the size of the body stores and aspects of expenditure. This model accommodates many of the social and environmental characteristics of energy balance, but struggles to explain some of the biological and genetic aspects. The shortcomings of these two models reflect their failure to address the gene-by-environment interactions that dominate the regulation of body weight. We discuss two additional models – the general intake model and the dual intervention point model – that address this issue and might offer better ways to understand how body fatness is controlled.

Preterm delivery predicted by soluble CD163 and CRP in women with symptoms of preterm delivery

DEFF Research Database (Denmark)

Vogel, Ida; Grove, Jakob; Thorsen, Poul

2005-01-01

: High levels of sCD163 or CRP are associated with an increased risk of preterm delivery in women with symptoms of delivery. Good prediction of preterm delivery before 34 weeks of gestation was obtained by a combination of preterm prelabour rupture of membranes (PPROM), overweight, relaxin, CRP and s...

Accounting for professionalism: an innovative point system to assess resident professionalism

Directory of Open Access Journals (Sweden)

Gary L. Malakoff

2014-04-01

Full Text Available Background: Professionalism is a core competency for residency required by the Accreditation Council of Graduate Medical Education. We sought a means to objectively assess professionalism among internal medicine and transitional year residents. Innovation: We established a point system to document unprofessional behaviors demonstrated by internal medicine and transitional year residents along with opportunities to redeem such negative points by deliberate positive professional acts. The intent of the policy is to assist residents in becoming aware of what constitutes unprofessional behavior and to provide opportunities for remediation by accruing positive points. A committee of core faculty and department leadership including the program director and clinic nurse manager determines professionalism points assigned. Negative points might be awarded for tardiness to mandatory or volunteered for events without a valid excuse, late evaluations or other paperwork required by the department, non-attendance at meetings prepaid by the department, and inappropriate use of personal days or leave. Examples of actions through which positive points can be gained to erase negative points include delivery of a mentored pre-conference talk, noon conference, medical student case/shelf review session, or a written reflection. Results: Between 2009 and 2012, 83 residents have trained in our program. Seventeen categorical internal medicine and two transitional year residents have been assigned points. A total of 55 negative points have been assigned and 19 points have been remediated. There appears to be a trend of fewer negative points and more positive points being assigned over each of the past three academic years. Conclusion: Commitment to personal professional behavior is a lifelong process that residents must commit to during their training. A professionalism policy, which employs a point system, has been instituted in our programs and may be a novel tool to

Drug delivery and formulations.

Science.gov (United States)

Breitkreutz, Jörg; Boos, Joachim

2011-01-01

Paediatric drug delivery is a major challenge in drug development. Because of the heterogeneous nature of the patient group, ranging from newborns to adolescents, there is a need to use appropriate excipients, drug dosage forms and delivery devices for different age groups. So far, there is a lack of suitable and safe drug formulations for children, especially for the very young and seriously ill patients. The new EU legislation will enforce paediatric clinical trials and drug development. Current advances in paediatric drug delivery include interesting new concepts such as fast-dissolving drug formulations, including orodispersible tablets and oral thin strips (buccal wafers), and multiparticulate dosage forms based on mini-tabletting or pelletization technologies. Parenteral administration is likely to remain the first choice for children in the neonatal period and for emergency cases. Alternative routes of administration include transdermal, pulmonary and nasal drug delivery systems. A few products are already available on the market, but others still need further investigations and clinical proof of concept.

Discussion of Environmental Problem and Study of Environmental Impact on Steel Industry in China

Institute of Scientific and Technical Information of China (English)

无

2002-01-01

The environmental conditions in steel industry were discussed in detail. It was also pointed out that it was necessary to reduce the quantity of waste generated and discharged by improving the raw material, energy structure and consumption rate, and reinforcing the waste control and management. At the same time, the relevant mathematical models of environmental impact were set up on the basis of raw material consumption, energy consumption and waste generation and discharge in different technical routes of steelmaking. The result showed that the production route of DR-iron clearly has more environmental advantages over that of BF-hot metal.

Preparing and evaluating delivery systems for proteins

DEFF Research Database (Denmark)

Jorgensen, L; Moeller, E H; van de Weert, M

2006-01-01

From a formulation perspective proteins are complex and therefore challenging molecules to develop drug delivery systems for. The success of a formulation depends on the ability of the protein to maintain the native structure and activity during preparation and delivery as well as during shipping...... and long-term storage of the formulation. Therefore, the development and evaluation of successful and promising drug delivery systems is essential. In the present review, some of the particulate drug delivery systems for parenteral delivery of protein are presented and discussed. The challenge...... for incorporation of protein in particulate delivery systems is exemplified by water-in-oil emulsions....

Hinkley Point 'C' power station public inquiry: statement of case

International Nuclear Information System (INIS)

1988-08-01

This Statement of Case contains full particulars of the case which the Central Electricity Generating Board (CEGB) proposes to put forward at the Hinkley Point ''C'' Inquiry. It relates to the planning application made by the CEGB for the construction of a 1200 MW Pressurized Water Reactor (PWR) power station at Hinkley Point in the United Kingdom, adjacent to an existing nuclear power station. The inquiry will consider economic, safety, environmental and planning matters relevant to the application and the implications for agriculture and local amenities of re-aligning two power transmission lines. The Statement contains submissions on the following matters: Topic 1 The Requirement for the Station; Topic 2 Safety and Design, including Radioactive Discharges; Topic 3 The On-Site Management of Radioactive Waste and Decommissioning of the Station; Topic 4 Emergency Arrangements; Topic 5 Local and Environmental Issues. (author)

Ultrasound-guided drug delivery in cancer

Energy Technology Data Exchange (ETDEWEB)

Chowdhury, Sayan Mullick; Lee, Tae Hwa; Willmann, Jugen K. [Dept. of Radiology, Stanford University School of Medicine, Stanford (United States)

2017-07-15

Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing systemic dose and toxicity. The mechanism behind enhanced delivery of therapeutics is sonoporation, the formation of openings in the vasculature, induced by ultrasound-triggered oscillations and destruction of microbubbles. In this review, progress and challenges of USMB mediated drug delivery are summarized, with special focus on cancer therapy.

Fiber coupled optical spark delivery system

Science.gov (United States)

Yalin, Azer; Willson, Bryan; Defoort, Morgan

2008-08-12

A spark delivery system for generating a spark using a laser beam is provided, the spark delivery system including a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. In addition, the laser delivery assembly includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. In accordance with embodiments of the present invention, the assembly may be used to create a spark in a combustion engine. In accordance with other embodiments of the present invention, a method of using the spark delivery system is provided. In addition, a method of choosing an appropriate fiber for creating a spark using a laser beam is also presented.

Resuscitation of newborn in high risk deliveries

International Nuclear Information System (INIS)

Yousaf, U.F.; Hayat, S.

2015-01-01

High risk deliveries are usually associated with increased neonatal mortality and morbidity. Neonatal resuscitation can appreciably affect the outcome in these types of deliveries. Presence of personnel trained in basic neonatal resuscitation at the time of delivery can play an important role in reducing perinatal complications in neonates at risk. The study was carried out to evaluate the effects of newborn resuscitation on neonatal outcome in high risk deliveries. Methods: This descriptive case series was carried out at the Department of Obstetrics and Gynecology, Jinnah Hospital, Lahore. Ninety consecutive high risk deliveries were included and attended by paediatricians trained in newborn resuscitation. Babies delivered by elective Caesarean section, normal spontaneous vaginal deliveries and still births were excluded. Neonatal resuscitation was performed in babies who failed to initiate breathing in the first minute after birth. Data was analyzed using SPSS-16.0. Results: A total of 90 high risk deliveries were included in the study. Emergency caesarean section was the mode of delivery in 94.4% (n=85) cases and spontaneous vaginal delivery in 5.6% (n=5). Preterm pregnancy was the major high risk factor. Newborn resuscitation was required in 37.8% (n=34) of all high risk deliveries (p=0.013). All the new-borns who required resuscitation survived. Conclusion: New-born resuscitation is required in high risk pregnancies and personnel trained in newborn resuscitation should be available at the time of delivery. (author)

Modeling environmental policy

International Nuclear Information System (INIS)

Martin, W.E.; McDonald, L.A.

1997-01-01

The eight book chapters demonstrate the link between the physical models of the environment and the policy analysis in support of policy making. Each chapter addresses an environmental policy issue using a quantitative modeling approach. The volume addresses three general areas of environmental policy - non-point source pollution in the agricultural sector, pollution generated in the extractive industries, and transboundary pollutants from burning fossil fuels. The book concludes by discussing the modeling efforts and the use of mathematical models in general. Chapters are entitled: modeling environmental policy: an introduction; modeling nonpoint source pollution in an integrated system (agri-ecological); modeling environmental and trade policy linkages: the case of EU and US agriculture; modeling ecosystem constraints in the Clean Water Act: a case study in Clearwater National Forest (subject to discharge from metal mining waste); costs and benefits of coke oven emission controls; modeling equilibria and risk under global environmental constraints (discussing energy and environmental interrelations); relative contribution of the enhanced greenhouse effect on the coastal changes in Louisiana; and the use of mathematical models in policy evaluations: comments. The paper on coke area emission controls has been abstracted separately for the IEA Coal Research CD-ROM

Emission taxes versus other environmental policies

Energy Technology Data Exchange (ETDEWEB)

Hoel, Michael

1997-06-01

In most countries, various forms of quotas and direct regulation play a more important role in environmental policy than environmental taxes. This report discusses four arguments often given against emission taxes. Three of the arguments, which are related to information asymmetries and non-convexities, are valid arguments in the sense that they point at complications which make the use of environmental taxes less straightforward than what elementary textbooks would suggest. The fourth argument is related to the employment effects of different types of environmental policies in economies with unemployment. This is perhaps the argument most often used by politicians against environmental taxes. The analysis did not justify this type of argument. On the contrary: In the model used, employment is higher with environmental taxes than with non revenue-raising environmental policies. 18 refs., 6 figs.

Ceramic drug-delivery devices.

Science.gov (United States)

Lasserre, A; Bajpai, P K

1998-01-01

A variety of ceramics and delivery systems have been used to deliver chemicals, biologicals, and drugs at various rates for desired periods of time from different sites of implantation. In vitro and in vivo studies have shown that ceramics can successfully be used as drug-delivery devices. Matrices, inserts, reservoirs, cements, and particles have been used to deliver a large variety of therapeutic agents such as antibiotics, anticancer drugs, anticoagulants, analgesics, growth factors, hormones, steroids, and vaccines. In this article, the advantages and disadvantages of conventional drug-delivery systems and the different approaches used to deliver chemical and biological agents by means of ceramic systems will be reviewed.

Vocal effectiveness of speech-language pathology students: Before and after voice use during service delivery

OpenAIRE

Couch, Stephanie; Zieba, Dominique; van der Linde, Jeannie; van der Merwe, Anita

2015-01-01

Background: As a professional voice user, it is imperative that a speech-language pathologist’s(SLP) vocal effectiveness remain consistent throughout the day. Many factors may contribute to reduced vocal effectiveness, including prolonged voice use, vocally abusive behaviours,poor vocal hygiene and environmental factors. Objectives: To determine the effect of service delivery on the perceptual and acoustic features of voice. Method: A quasi-experimental., pre-test–post-test research de...

Vaginal delivery versus cesarean section for term breech delivery

Directory of Open Access Journals (Sweden)

Babović Ivana

2010-01-01

Full Text Available Background/Aim. The optimal method of delivery for breech presentation at term still remains a matter of controversy. This is probably due to the fact that the skills of vaginal breech delivery are being lost. The aim of this study was to examine risk factors: mother's age, parity, labor's duration, estimated neonatal birth weight for the mode of breech presentation delivery at term as well as the influence of the delivery mode on neonatal outcome. Methods. A retrospective study of 401 terms (more than 37 week's gestation breech deliveries at the Institute of Gynecology and Obstetrics, Belgrade, from 2007 to 2008 was made. The following groups with respect to mode of delivery were included: the group I - vaginal delivery (VD in 139 patients; the group II - urgent cesarean section (UCS in 128 patients; and the group III - elective cesarean section (ECS in 134 patients. Mother's age, parity, duration of VD, neonatal birth weight (BW, the Apgar score at 5th minute, and duration of stay in a neonatal intensive care unit (NICU vere determined. Neonatal mortality and major neonatal morbidity were compared according to the route of delivery. Fetuses and neonates with hemolytic disease and fetal and neonatal anomalies were excluded from the study. For statistical analyses we performed Student's t test, χ2 likelihood ratio, Kruskall-Wallis test, Mann Whitney test, and ANOVA. Results. The mean age of patients in the group I was 28.29 ± 4.97 years, in the group II 29.68 ± 5.92 years and in the group III 30.06 ± 5.41 years. Difference in mother's age between the group I and III was significant (p = 0.022. In the group III there were 73.9% nuliparous similarly to the gropu II (73.4%. We performed ECS in 54.6% of the nuliparous older than 35 years, and 54.4% multiparous younger than 35 years were delivered by VD. The use of oxytocin for stimulation of vaginal labor was not associated with its duration (p = 0.706. Lowset maneuver was performed in 88.5% of

Ultrasound-guided drug delivery in cancer

Directory of Open Access Journals (Sweden)

Sayan Mullick Chowdhury

2017-07-01

Full Text Available Recent advancements in ultrasound and microbubble (USMB mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing systemic dose and toxicity. The mechanism behind enhanced delivery of therapeutics is sonoporation, the formation of openings in the vasculature, induced by ultrasound-triggered oscillations and destruction of microbubbles. In this review, progress and challenges of USMB mediated drug delivery are summarized, with special focus on cancer therapy.

Health care delivery systems.

NARCIS (Netherlands)

Stevens, F.; Zee, J. van der

2007-01-01

A health care delivery system is the organized response of a society to the health problems of its inhabitants. Societies choose from alternative health care delivery models and, in doing so, they organize and set goals and priorities in such a way that the actions of different actors are effective,

Variability of building environmental assessment tools on evaluating carbon emissions

Energy Technology Data Exchange (ETDEWEB)

Ng, S. Thomas, E-mail: tstng@hkucc.hku.hk; Chen Yuan, E-mail: chenyuan4@gmail.com; Wong, James M.W., E-mail: jmwwong@hku.hk

2013-01-15

With an increasing importance of sustainability in construction, more and more clients and designers employ building environmental assessment (BEA) tools to evaluate the environmental friendliness of their building facilities, and one important aspect of evaluation in the BEA models is the assessment of carbon emissions. However, in the absence of any agreed framework for carbon auditing and benchmarking, the results generated by the BEA tools might vary significantly which could lead to confusion or misinterpretation on the carbon performance of a building. This study thus aims to unveil the properties of and the standard imposed by the current BEA models on evaluating the life cycle carbon emissions. The analyses cover the (i) weighting of energy efficiency and emission levels among various environmental performance indicators; (ii) building life cycle stages in which carbon is taken into consideration; (iii) objectiveness of assessment; (iv) baseline set for carbon assessment; (v) mechanism for benchmarking the emission level; and (v) limitations of the carbon assessment approaches. Results indicate that the current BEA schemes focus primarily on operational carbon instead of the emissions generated throughout the entire building life cycle. Besides, the baseline and benchmark for carbon evaluation vary significantly among the BEA tools based on the analytical results of a hypothetical building. The findings point to the needs for a more transparent framework for carbon auditing and benchmarking in BEA modeling. - Highlights: Black-Right-Pointing-Pointer Carbon emission evaluation in building environmental assessment schemes are studied. Black-Right-Pointing-Pointer Simulative carbon emission is modeled for building environmental assessment schemes. Black-Right-Pointing-Pointer Carbon assessments focus primarily on operational stage instead of entire lifecycle. Black-Right-Pointing-Pointer Baseline and benchmark of carbon assessment vary greatly among BEA

The environmental impact of changing consumption patterns: a survey

DEFF Research Database (Denmark)

Røpke, Inge

2001-01-01

How does environmental impact change when national income increases? So far, this question has been mainly discussed from the point of view of production, but in recent years several studies have dealt with the question of decoupling from the point of view of consumption. The optimistic subscribers...... assessment of the environmental impact is most appropriately based on an input approach. Then data on input intensities for different categories of consumption goods are combined with data on changes in consumption patterns, and it is concluded that the historical changes in the composition of consumption...... seem to have done little to counterbalance the environmental effects of growth....

Tipping Points, Great and Small

Science.gov (United States)

Morrison, Foster

2010-12-01

The Forum by Jordan et al. [2010] addressed environmental problems of various scales in great detail, but getting the critical message through to the formulators of public policies requires going back to basics, namely, that exponential growth (of a population, an economy, or most anything else) is not sustainable. When have you heard any politician or economist from anywhere across the ideological spectrum say anything other than that more growth is essential? There is no need for computer models to demonstrate “limits to growth,” as was done in the 1960s. Of course, as one seeks more details, the complexity of modeling will rapidly outstrip the capabilities of both observation and computing. This is common with nonlinear systems, even simple ones. Thus, identifying all possible “tipping points,” as suggested by Jordan et al. [2010], and then stopping just short of them, is impractical if not impossible. The main thing needed to avoid environmental disasters is a bit of common sense.

The USEPA environmental response team TAGA at work at the Hart building fumigation

Energy Technology Data Exchange (ETDEWEB)

Mickunas, D.B.; Turpin, R. [United States Environmental Protection Agency, Edison, NJ (United States). Environmental Response Team; Blaze, S.; Wood, J. [Lockheed Martin Inc., Edison, NJ (United States). Response Engineering and Analytical Contract

2004-07-01

This paper describes the fumigation activities conducted at the Hart Senate Office building in Washington, DC in October 2001 following the delivery of a letter containing anthrax. Anthrax spores were dispersed in areas within the office. The United States States Environmental Protection Agency Environmental Response Team (USEPA/ERT) was responsible for the decontamination activities. Chlorine dioxide was chosen as the anthrax sporicide after a detailed technical review and consultation with scientific experts. ERT provided continuous, near real-time ambient air monitoring during the fumigation process. The monitoring was conducted to ensure that the nearby residences were not impacted by the chlorine dioxide fumigant. The monitoring plan required the use of a Trace Atmospheric Gas Analyzer (TAGA), a triple quadrupole mass spectrometer mounted in a mobile laboratory. The monitoring activities of ERT's mobile laboratory were outlined in this paper along with the logistical and technical aspects of the air monitoring. More than 130 hours of TAGA monitoring was performed and 2.3 million data points were collected. No chlorine or chlorine dioxide concentrations were observed above the action limits during any fumigation event. The building was cleared by the health and regulatory agencies and re-opened in January 2002. It was concluded that TAGA is an excellent technology to monitor these compounds because is is extremely sensitive and selective. 2 tabs., 5 figs.

20 CFR 628.405 - Service delivery areas.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Service delivery areas. 628.405 Section 628... TITLE II OF THE JOB TRAINING PARTNERSHIP ACT Local Service Delivery System § 628.405 Service delivery... evaluate the degree to which a proposed service delivery area meets criteria established by the Governor...

Rabbit Lake uranium mining a-zone, d-zone, eagle point: report of the environmental assessment panel

International Nuclear Information System (INIS)

1993-11-01

A report of the environmental assessment panel on Rabbit Lake, Saskatchewan. A review of the proposed development of the uranium mining facility at Rabbit Lake with respect to the environmental, health, safety, and socioeconomic impacts

Rabbit Lake uranium mining a-zone, d-zone, eagle point: report of the environmental assessment panel

Energy Technology Data Exchange (ETDEWEB)

NONE

1993-11-01

A report of the environmental assessment panel on Rabbit Lake, Saskatchewan. A review of the proposed development of the uranium mining facility at Rabbit Lake with respect to the environmental, health, safety, and socioeconomic impacts.

Implementation of a chronic unilateral intraparenchymal drug delivery system in a swine model.

Science.gov (United States)

Kim, Inyong; Paek, Seungleal; Nelson, Brian D; Knight, Emily J; Marsh, Michael P; Bieber, Allan J; Bennet, Kevin E; Lee, Kendall H

2014-04-30

Systemic delivery of pharmacologic agents has led to many significant advances in the treatment of neurologic and psychiatric conditions. However, this approach has several limitations, including difficulty penetrating the blood-brain barrier and enzymatic degradation prior to reaching its intended target. Here, we describe the testing of a system allowing intraparenchymal (IPa) infusion of therapeutic agents directly to the appropriate anatomical targets, in a swine model. Five male pigs underwent 3.0T magnetic resonance (MR) guided placement of an IPa catheter into the dorso-medial putamen, using a combined system of the Leksell stereotactic arc, a Mayo-developed MRI-compatible pig head frame, and a custom-designed Fred Haer Company (FHC) delivery system. Our results show hemi-lateral coverage of the pig putamen is achievable from a single infusion point and that the volume of the bolus detected in each animal is uniform (1544±420mm(3)). The IPa infusion system is designed to isolate the intracranial catheter from bodily-induced forces while delivering drugs and molecules into the brain tissue by convection-enhanced delivery, with minimal-to-no catheter track backflow. This study presents an innovative IPa drug delivery system, which includes a sophisticated catheter and implantable pump designed to deliver drugs and various molecules in a precise and controlled manner with limited backflow. It also demonstrates the efficacy of the delivery system, which has the potential to radically impact the treatment of a wide range of neurologic conditions. Lastly, the swine model used here has certain advantages for translation into clinical applications. Copyright © 2014 Elsevier B.V. All rights reserved.

River Bank Erosion and the Influence of Environmental Flow Management

Science.gov (United States)

Vietz, Geoff J.; Lintern, Anna; Webb, J. Angus; Straccione, David

2018-03-01

Environmental flows aim to influence river hydrology to provide appropriate physical conditions for ecological functioning within the restrictions of flow regulation. The hydrologic characteristics of flow events, however, may also lead to unintended morphologic effects in rivers, such as increases in riverbank erosion beyond natural rates. This may negatively impact habitat for biota, riparian infrastructure, and land use. Strategic environmental flow delivery linked to monitoring and adaptive management can help mitigate risks. We monitor riverbank condition (erosion and deposition) relative to environmental flows on the Goulburn River, Victoria, Australia. We describe the process of adaptive management aimed at reducing potential impacts of flow management on bank condition. Field measurements (erosion pins) quantify the hydrogeomorphic response of banks to the delivery of planned and natural flow events. Managed flows provide opportunities for monitoring riverbank response to flows, which in turn informs planning. The results demonstrate that environmental flows have little influence on bank erosion and visual perceptions in the absence of monitoring are an unreliable guide. This monitoring project represents a mutually beneficial, science-practice partnership demonstrating that a traditional `know then do' approach can be foreshortened by close collaboration between researchers and managers. To do so requires transparent, often informal lines of communication. The benefits for researchers-a more strategic and targeted approach to monitoring activities; and benefits for the practitioners-reduced time between actions and understanding response; mean that a learn by doing approach is likely to have better outcomes for researchers, stakeholders, the public, and the environment.

River Bank Erosion and the Influence of Environmental Flow Management.

Science.gov (United States)

Vietz, Geoff J; Lintern, Anna; Webb, J Angus; Straccione, David

2018-03-01

Environmental flows aim to influence river hydrology to provide appropriate physical conditions for ecological functioning within the restrictions of flow regulation. The hydrologic characteristics of flow events, however, may also lead to unintended morphologic effects in rivers, such as increases in riverbank erosion beyond natural rates. This may negatively impact habitat for biota, riparian infrastructure, and land use. Strategic environmental flow delivery linked to monitoring and adaptive management can help mitigate risks. We monitor riverbank condition (erosion and deposition) relative to environmental flows on the Goulburn River, Victoria, Australia. We describe the process of adaptive management aimed at reducing potential impacts of flow management on bank condition. Field measurements (erosion pins) quantify the hydrogeomorphic response of banks to the delivery of planned and natural flow events. Managed flows provide opportunities for monitoring riverbank response to flows, which in turn informs planning. The results demonstrate that environmental flows have little influence on bank erosion and visual perceptions in the absence of monitoring are an unreliable guide. This monitoring project represents a mutually beneficial, science-practice partnership demonstrating that a traditional 'know then do' approach can be foreshortened by close collaboration between researchers and managers. To do so requires transparent, often informal lines of communication. The benefits for researchers-a more strategic and targeted approach to monitoring activities; and benefits for the practitioners-reduced time between actions and understanding response; mean that a learn by doing approach is likely to have better outcomes for researchers, stakeholders, the public, and the environment.

Microspheres and Nanotechnology for Drug Delivery.

Science.gov (United States)

Jóhannesson, Gauti; Stefánsson, Einar; Loftsson, Thorsteinn

2016-01-01

Ocular drug delivery to the posterior segment of the eye can be accomplished by invasive drug injections into different tissues of the eye and noninvasive topical treatment. Invasive treatment involves the risks of surgical trauma and infection, and conventional topical treatments are ineffective in delivering drugs to the posterior segment of the eye. In recent years, nanotechnology has become an ever-increasing part of ocular drug delivery. In the following, we briefly review microspheres and nanotechnology for drug delivery to the eye, including different forms of nanotechnology such as nanoparticles, microparticles, liposomes, microemulsions and micromachines. The permeation barriers and anatomical considerations linked to ocular drug delivery are discussed and a theoretical overview on drug delivery through biological membranes is given. Finally, in vitro, in vivo and human studies of x03B3;-cyclodextrin nanoparticle eyedrop suspensions are discussed as an example of nanotechnology used for drug delivery to the eye. © 2016 S. Karger AG, Basel.

Regional scale modeling of hill slope sediment delivery: a case study in the Esera-Isabena watershed, central Spanish Pyrenees, with WATEM/SEDEM

Energy Technology Data Exchange (ETDEWEB)

Alatorre, L. C.; Begueria, S.; Garcia-Ruiz, J. M.

2009-07-01

Soil ersoion and sediment delivery to streams is an important environmental problem and a major concern for sustainable development. The spatial nature of soil erosion and sediment delivery, as well as the variety of possible soil conservation and sediment control measures, require an integrated approach to catchment management. A spatially-distributed soil erosion and sediment delivery model (WATEM/SEDEM) was applied to the watershed of the Barasona Reservoir (1504 km{sup 2}, central Spanish Pyrenees), which is drained by the Esera and Isabena rivers. Several input data layers with a 20 x 20 m resolution were derived using a GIS package comprising a digital terrain model (DTM), and stream network, land use, rainfall erosivity, soil erodibility and crop management factors. (Author) 6 refs.

Regional scale modeling of hill slope sediment delivery: a case study in the Esera-Isabena watershed, central Spanish Pyrenees, with WATEM/SEDEM

International Nuclear Information System (INIS)

Alatorre, L. C.; Begueria, S.; Garcia-Ruiz, J. M.

2009-01-01

Soil ersoion and sediment delivery to streams is an important environmental problem and a major concern for sustainable development. The spatial nature of soil erosion and sediment delivery, as well as the variety of possible soil conservation and sediment control measures, require an integrated approach to catchment management. A spatially-distributed soil erosion and sediment delivery model (WATEM/SEDEM) was applied to the watershed of the Barasona Reservoir (1504 km 2 , central Spanish Pyrenees), which is drained by the Esera and Isabena rivers. Several input data layers with a 20 x 20 m resolution were derived using a GIS package comprising a digital terrain model (DTM), and stream network, land use, rainfall erosivity, soil erodibility and crop management factors. (Author) 6 refs.

Oral delivery of anticancer drugs

DEFF Research Database (Denmark)

Thanki, Kaushik; Gangwal, Rahul P; Sangamwar, Abhay T

2013-01-01

The present report focuses on the various aspects of oral delivery of anticancer drugs. The significance of oral delivery in cancer therapeutics has been highlighted which principally includes improvement in quality of life of patients and reduced health care costs. Subsequently, the challenges...... incurred in the oral delivery of anticancer agents have been especially emphasized. Sincere efforts have been made to compile the various physicochemical properties of anticancer drugs from either literature or predicted in silico via GastroPlus™. The later section of the paper reviews various emerging...... trends to tackle the challenges associated with oral delivery of anticancer drugs. These invariably include efflux transporter based-, functional excipient- and nanocarrier based-approaches. The role of drug nanocrystals and various others such as polymer based- and lipid based...

Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis

Directory of Open Access Journals (Sweden)

Xi J

2015-07-01

Full Text Available Jinxiang Xi,1 Jiayao Eddie Yuan,1 Xiuhua April Si,2 James Hasbany1 1School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI, 2Department of Mechanical Engineering, California Baptist University, Riverside, CA, USA Background: Despite the prevalence of rhinosinusitis that affects 10%–15% of the population, current inhalation therapy shows limited efficacy. Standard devices deliver <5% of the drugs to the sinuses due to the complexity of nose structure, secluded location of the sinus, poor ventilation, and lack of control of particle motions inside the nasal cavity. Methods: An electric-guided delivery system was developed to guide charged particles to the ostiomeatal complex (OMC. Its performance was numerically assessed in an MRI-based nose–sinus model. Key design variables related to the delivery device, drug particles, and patient breathing were determined using sensitivity analysis. A two-stage optimization of design variables was conducted to obtain the best performance of the delivery system using the Nelder-Mead algorithm. Results and discussion: The OMC delivery system exhibited high sensitivity to the applied electric field and electrostatic charges carried by the particles. Through the synthesis of electric guidance and point drug release, the new delivery system eliminated particle deposition in the nasal valve and turbinate regions and significantly enhanced the OMC doses. An OMC delivery efficiency of 72.4% was obtained with the optimized design, which is one order of magnitude higher than the standard nasal devices. Moreover, optimization is imperative to achieve a sound delivery protocol because of the large number of design variables. The OMC dose increased from 45.0% in the baseline model to 72.4% in the optimized system. The optimization framework developed in this study can be easily adapted for the delivery of drugs to other sites in the nose such as the ethmoid sinus and olfactory region

Reaching Rural Handicapped Children: The Transportation Situation in Rural Service Delivery. Making It Work in Rural Communities. A Rural Network Monograph.

Science.gov (United States)

Tucker, Jamie; And Others

Almost everyone who responded to three transportation surveys of rural Handicapped Children's Early Education Program (HCEEP) projects identified transportation as a critical problem in the delivery of services to handicapped children in rural areas. Transportation problems encountered were attributed to environmental/geographic factors,…

Cloud point extraction and spectrophotometric determination of mercury species at trace levels in environmental samples.

Science.gov (United States)

Ulusoy, Halil İbrahim; Gürkan, Ramazan; Ulusoy, Songül

2012-01-15

A new micelle-mediated separation and preconcentration method was developed for ultra-trace quantities of mercury ions prior to spectrophotometric determination. The method is based on cloud point extraction (CPE) of Hg(II) ions with polyethylene glycol tert-octylphenyl ether (Triton X-114) in the presence of chelating agents such as 1-(2-pyridylazo)-2-naphthol (PAN) and 4-(2-thiazolylazo) resorcinol (TAR). Hg(II) ions react with both PAN and TAR in a surfactant solution yielding a hydrophobic complex at pH 9.0 and 8.0, respectively. The phase separation was accomplished by centrifugation for 5 min at 3500 rpm. The calibration graphs obtained from Hg(II)-PAN and Hg(II)-TAR complexes were linear in the concentration ranges of 10-1000 μg L(-1) and 50-2500 μg L(-1) with detection limits of 1.65 and 14.5 μg L(-1), respectively. The relative standard deviations (RSDs) were 1.85% and 2.35% in determinations of 25 and 250 μg L(-1) Hg(II), respectively. The interference effect of several ions were studied and seen commonly present ions in water samples had no significantly effect on determination of Hg(II). The developed methods were successfully applied to determine mercury concentrations in environmental water samples. The accuracy and validity of the proposed methods were tested by means of five replicate analyses of the certified standard materials such as QC Metal LL3 (VWR, drinking water) and IAEA W-4 (NIST, simulated fresh water). Copyright © 2011 Elsevier B.V. All rights reserved.

Route of delivery following successful external cephalic version.

Science.gov (United States)

Policiano, Catarina; Costa, Ana; Valentim-Lourenço, Alexandre; Clode, Nuno; Graça, Luís M

2014-09-01

To evaluate the delivery route and the indications for cesarean delivery after successful external cephalic version (ECV). A retrospective matched case-control study was conducted at a hospital in Lisbon, Portugal, between 2002 and 2012. Each woman who underwent successful ECV (n = 44) was compared with the previous and next women who presented for labor management and who had the same parity and a singleton vertex pregnancy at term (n = 88). The outcome measures were route of delivery, indications for cesarean delivery, and incidence of nonreassuring fetal status. Attempts at ECV were successful in 62 (46%) of 134 women, and 44 women whose fetuses remained in a cephalic presentation until delivery were included in the study. The rates of intrapartum cesarean delivery and operative vaginal delivery did not differ significantly between cases and controls (intrapartum cesarean delivery, 9 [20%] vs 16 [18%], P = 0.75; operative vaginal delivery, 14 [32%] vs 19 [22%], P = 0.20). The indications for cesarean delivery after successful ECV did not differ; in both groups, cesarean delivery was mainly performed for labor arrest disorders (cases, 6 [67%] vs controls, 13 [81%]; P = 0.63). Successful ECV was not associated with increased rates of intrapartum cesarean delivery or operative vaginal delivery. Copyright © 2014 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

Relationship between Deck Level, Body Surface Temperature and Carcass Damages in Italian Heavy Pigs after Short Journeys at Different Unloading Environmental Conditions

Directory of Open Access Journals (Sweden)

Agnese Arduini

2017-02-01

Full Text Available In order to evaluate the relationships between deck level, body surface temperature and carcass damages after a short journey (30 min, 10 deliveries of Italian heavy pigs, including a total of 1400 animals from one farm, were examined. Within 5 min after the arrival at the abattoir, the vehicles were unloaded. Environmental temperature and relative humidity were recorded and a Temperature Humidity Index (THI was calculated. After unloading, maximum temperatures of dorsal and ocular regions were measured by a thermal camera on groups of pigs from each of the unloaded decks. After dehairing, quarters and whole carcasses were evaluated subjectively by a trained operator for skin damage using a four-point scale. On the basis of THI at unloading, deliveries were grouped into three classes. Data of body surface temperature and skin damage score were analysed in a model including THI class, deck level and their interaction. Regardless of pig location in the truck, the maximum temperature of the dorsal and ocular regions increased with increasing THI class. Within each THI class, the highest and lowest body surface temperatures were found in pigs located on the middle and upper decks, respectively. Only THI class was found to affect the skin damage score (p < 0.05, which increased on quarters and whole carcasses with increasing THI class. The results of this study on short-distance transport of Italian heavy pigs highlighted the need to control and ameliorate the environmental conditions in the trucks, even at relatively low temperature and THI, in order to improve welfare and reduce loss of carcass value.

A real-time virtual delivery system for photon radiotherapy delivery monitoring

Directory of Open Access Journals (Sweden)

Feng Shi

2014-03-01

Full Text Available Purpose: Treatment delivery monitoring is important for radiotherapy, which enables catching dosimetric error at the earliest possible opportunity. This project develops a virtual delivery system to monitor the dose delivery process of photon radiotherapy in real-time using GPU-based Monte Carlo (MC method.Methods: The simulation process consists of 3 parallel CPU threads. A thread T1 is responsible for communication with a linac, which acquires a set of linac status parameters, e.g. gantry angles, MLC configurations, and beam MUs every 20 ms. Since linac vendors currently do not offer interface to acquire data in real time, we mimic this process by fetching information from a linac dynalog file at the set frequency. Instantaneous beam fluence map (FM is calculated based. A FM buffer is also created in T1 and the instantaneous FM is accumulated to it. This process continues, until a ready signal is received from thread T2 on which an in-house developed MC dose engine executes on GPU. At that moment, the accumulated FM is transferred to T2 for dose calculations, and the FM buffer in T1 is cleared. Once the dose calculation finishes, the resulting 3D dose distribution is directed to thread T3, which displays it in three orthogonal planes in color wash overlaid on the CT image. This process continues to monitor the 3D dose distribution in real-time.Results: An IMRT and a VMAT cases used in our patient-specific QA are studied. Maximum dose differences between our system and treatment planning system are 0.98% and 1.58% for the IMRT and VMAT cases, respectively. The update frequency is >10Hz and the relative uncertainty level is 2%.Conclusion: By embedding a GPU-based MC code in a novel data/work flow, it is possible to achieve real-time MC dose calculations to monitor delivery process.------------------------------Cite this article as: Shi F, Gu X, Graves YJ, Jiang S, Jia X. A real-time virtual delivery system for photon radiotherapy delivery

Oral delivery of peptides and proteins using lipid-based drug delivery systems.

Science.gov (United States)

Li, Ping; Nielsen, Hanne Mørck; Müllertz, Anette

2012-10-01

In order to successfully develop lipid-based drug delivery systems (DDS) for oral administration of peptides and proteins, it is important to gain an understanding of the colloid structures formed by these DDS, the mode of peptide and protein incorporation as well as the mechanism by which intestinal absorption of peptides and proteins is promoted. The present paper reviews the literature on lipid-based DDS, employed for oral delivery of peptides and proteins and highlights the mechanisms by which the different lipid-based carriers are expected to overcome the two most important barriers (extensive enzymatic degradation and poor transmucosal permeability). This paper also gives a clear-cut idea about advantages and drawbacks of using different lipidic colloidal carriers ((micro)emulsions, solid lipid core particles and liposomes) for oral delivery of peptides and proteins. Lipid-based DDS are safe and suitable for oral delivery of peptides and proteins. Significant progress has been made in this area with several technologies on clinical trials. However, a better understanding of the mechanism of action in vivo is needed in order to improve the design and development of lipid-based DDS with the desired bioavailability and therapeutic profile.

Cesarean deliveries and maternal weight retention.

Science.gov (United States)

Kapinos, Kandice A; Yakusheva, Olga; Weiss, Marianne

2017-10-04

Cesarean delivery accounts for nearly one-third of all births in the U.S. and contributes to an additional $38 billion in healthcare costs each year. Although Cesarean delivery has a long record of improving maternal and neonatal mortality and morbidity, increased utilization over time has yielded public health concerns and calls for reductions. Observational evidence suggests Cesarean delivery is associated with increased maternal postpartum weight, which may have significant implications for the obesity epidemic. Previous literature, however, typically does not address selection biases stemming from correlations of pre-pregnancy weight and reproductive health with Cesarean delivery. We used fetal malpresentation as a natural experiment as it predicts Cesarean delivery but is uncorrelated with pre-pregnancy weight or maternal health. We used hospital administrative data (including fields used in vital birth record) from the state of Wisconsin from 2006 to 2013 to create a sample of mothers with at least two births. Using propensity score methods, we compared maternal weight prior to the second pregnancy of mothers who delivered via Cesarean due to fetal malpresentation to mothers who deliver vaginally. We found no evidence that Cesarean delivery in the first pregnancy causally leads to greater maternal weight, BMI, or movement to a higher BMI classification prior to the second pregnancy. After accounting for correlations between pre-pregnancy weight, gestational weight gain, and mode of delivery, there is no evidence of a causal link between Cesarean delivery and maternal weight retention.

An overview of polymeric dosage forms in buccal drug delivery: State of art, design of formulations and their in vivo performance evaluation.

Science.gov (United States)

Fonseca-Santos, Bruno; Chorilli, Marlus

2018-05-01

Owing to the ease of the administration, the oral cavity is an attractive site for the delivery of drugs. The main difficulty for administration via the buccal route is an effective physiological removal mechanism of the oral cavity that takes way the formulation from the buccal site and decreases the bioavailability of drugs. The use of mucoadhesive polymers in buccal drug delivery shows assessing buccal drug permeation and absorption, however some studies bring an in vivo performance. This review points to the use of polymers in the manufacture of drug delivery systems (hydrogels, films and tablets) and shows the results of their in vivo performance tests. Copyright © 2018 Elsevier B.V. All rights reserved.

The holistic 3M modality of drug delivery nanosystems for cancer therapy

Science.gov (United States)

Sun, Jin; Luo, Cong; Wang, Yongjun; He, Zhonggui

2013-01-01

Cancer has become the leading cause of human death worldwide. There are many challenges in the treatment of cancer and the rapidly developing area of nanotechnology has shown great potential to open a new era in cancer therapy. This article, rather than being exhaustive, focuses on the striking progress in the drug delivery nanosystems (DDNS) for cancer therapy and selects typical examples to point out the emerging mode of action of DDNS from our perspective. Among the outstanding advances in DDNS for cancer therapy is the development of ``multicomponent delivery systems'', ``multifunctional nanocarriers'' and ``multistage delivery systems''. However, these represent only one aspect of DDNS research. In addition, nature is the best teacher and natural evolution pressure has meant that virions conform to the ``multitarget, multistage and multicomponent'' (3M) mode of action. Amazingly, traditional Chinese medicine (TCM), used for over 4000 years in China, also displays the same mode of action. Integrating the previous notable progress in nanoparticle technology, learned from the building mode of natural virions and the action concept of TCM, we propose an integrity-based 3M mode DDNS for cancer therapy: multitarget, multistage and multicomponent, which are not fragmented parts but an interconnected integrity. Based on the physiological multitarget and the pharmacokinetic multistage, multicomponent DDNS are rationally designed, where different components with individual specific functions act in a synergistic manner against each target at each disposition stage to maximize the targeted delivery effectiveness. In this article, we introduce each component of 3M DDNS in detail and describe some typical cases to realize the tumor-homing purposes.

STRATEGIES AND PROSPECTS OF NASAL DRUG DELIVERY SYSTEMS

OpenAIRE

Gannu Praveen Kumar

2012-01-01

The recent advancement of nasal drug delivery systems has increased enormously and is gaining significant importance. Intranasal therapy has been an accepted form of treatment in the Ayurvedic system of Indian Medicine. The non-invasive delivery of nasal drug delivery systems made to exploit for the development of successful treatment. The advantages, disadvantages, mechanism of action and application of nasal drug delivery system in local delivery, systematic delivery, nasal vaccines and CNS...

Evaluation of the Agricultural Non-point Source Pollution in Chongqing Based on PSR Model

Institute of Scientific and Technical Information of China (English)

Hanwen; ZHANG; Xinli; MOU; Hui; XIE; Hong; LU; Xingyun; YAN

2014-01-01

Through a series of exploration based on PSR framework model,for the purpose of building a suitable Chongqing agricultural nonpoint source pollution evaluation index system model framework,combined with the presence of Chongqing specific agro-environmental issues,we build a agricultural non-point source pollution assessment index system,and then study the agricultural system pressure,agro-environmental status and human response in total 3 major categories,develope an agricultural non-point source pollution evaluation index consisting of 3 criteria indicators and 19 indicators. As can be seen from the analysis,pressures and responses tend to increase and decrease linearly,state and complex have large fluctuations,and their fluctuations are similar mainly due to the elimination of pressures and impact,increasing the impact for agricultural non-point source pollution.

Fast and direct measurements of the electrical properties of graphene using micro four-point probes

DEFF Research Database (Denmark)

Klarskov, Mikkel Buster; Dam, Henrik Friis; Petersen, Dirch Hjorth

2011-01-01

. Measurements are performed in ambient, vacuum and controlled environmental conditions using an environmental scanning electron microscope (SEM). The results are comparable to previous results for microcleaved graphene on silicon dioxide (SiO2). We observe a pronounced hysteresis of the charge neutrality point...

Induced Temporal Signatures for Point-Source Detection

International Nuclear Information System (INIS)

Stephens, Daniel L.; Runkle, Robert C.; Carlson, Deborah K.; Peurrung, Anthony J.; Seifert, Allen; Wyatt, Cory R.

2005-01-01

Detection of radioactive point-sized sources is inherently divided into two regimes encompassing stationary and moving detectors. The two cases differ in their treatment of background radiation and its influence on detection sensitivity. In the stationary detector case the statistical fluctuation of the background determines the minimum detectable quantity. In the moving detector case the detector may be subjected to widely and irregularly varying background radiation, as a result of geographical and environmental variation. This significant systematic variation, in conjunction with the statistical variation of the background, requires a conservative threshold to be selected to yield the same false-positive rate as the stationary detection case. This results in lost detection sensitivity for real sources. This work focuses on a simple and practical modification of the detector geometry that increase point-source recognition via a distinctive temporal signature. A key part of this effort is the integrated development of both detector geometries that induce a highly distinctive signature for point sources and the development of statistical algorithms able to optimize detection of this signature amidst varying background. The identification of temporal signatures for point sources has been demonstrated and compared with the canonical method showing good results. This work demonstrates that temporal signatures are efficient at increasing point-source discrimination in a moving detector system

New England observed and predicted August stream/river temperature daily range points

Data.gov (United States)

U.S. Environmental Protection Agency — The shapefile contains points with associated observed and predicted August stream/river temperature daily ranges in New England based on a spatial statistical...

AMCO Scribe Sampling Data Points, Oakland CA, 2017, US EPA Region 9

Data.gov (United States)

U.S. Environmental Protection Agency — This feature class contains points depicting archived sampling data for Vinyl Chloride, Trichloroethene (TCE), and Tetrachloroethene (PCE) for the R09 AMCO-OTIE...

New England observed and predicted growing season maximum stream/river temperature points

Data.gov (United States)

U.S. Environmental Protection Agency — The shapefile contains points with associated observed and predicted growing season maximum stream/river temperatures in New England based on a spatial statistical...

Fast cine-magnetic resonance imaging point tracking for prostate cancer radiation therapy planning

International Nuclear Information System (INIS)

Dowling, J; Chandra, S; Dang, K; Fox, Chris D; Gill, Suki; Kron, T; Pham, D; Foroudi, F

2014-01-01

The analysis of intra-fraction organ motion is important for improving the precision of radiation therapy treatment delivery. One method to quantify this motion is for one or more observers to manually identify anatomic points of interest (POIs) on each slice of a cine-MRI sequence. However this is labour intensive and inter- and intra- observer variation can introduce uncertainty. In this paper a fast method for non-rigid registration based point tracking in cine-MRI sagittal and coronal series is described which identifies POIs in 0.98 seconds per sagittal slice and 1.35 seconds per coronal slice. The manual and automatic points were highly correlated (r>0.99, p<0.001) for all organs and the difference generally less than 1mm. For prostate planning peristalsis and rectal gas can result in unpredictable out of plane motion, suggesting the results may require manual verification.

Environmental Report 1996, Volume 2

Energy Technology Data Exchange (ETDEWEB)

Harrach, R.J.

1996-01-01

This is Volume 2 of the Lawrence Livermore National Laboratory`s (LLNL`s) annual Environmental Report 1996, prepared for the US Department of Energy. Volume 2 supports Volume 1 summary data and is essentially a detailed data report that provides individual data points, where applicable. Volume 2 includes information on monitoring of air, air effluents, sewerable water, surface water, ground water, soil and sediment, vegetation and foodstuff, environmental radiation, and quality assurance.

A Lexical Analysis of Environmental Sound Categories

Science.gov (United States)

Houix, Olivier; Lemaitre, Guillaume; Misdariis, Nicolas; Susini, Patrick; Urdapilleta, Isabel

2012-01-01

In this article we report on listener categorization of meaningful environmental sounds. A starting point for this study was the phenomenological taxonomy proposed by Gaver (1993b). In the first experimental study, 15 participants classified 60 environmental sounds and indicated the properties shared by the sounds in each class. In a second…

Exceptional Points and Dynamical Phase Transitions

Directory of Open Access Journals (Sweden)

I. Rotter

2010-01-01

Full Text Available In the framework of non-Hermitian quantum physics, the relation between exceptional points,dynamical phase transitions and the counter intuitive behavior of quantum systems at high level density is considered. The theoretical results obtained for open quantum systems and proven experimentally some years ago on a microwave cavity, may explain environmentally induce deffects (including dynamical phase transitions, which have been observed in various experimental studies. They also agree(qualitatively with the experimental results reported recently in PT symmetric optical lattices.

48 CFR 52.211-8 - Time of Delivery.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Time of Delivery. 52.211-8... Delivery. As prescribed in 11.404(a)(2), insert the following clause: Time of Delivery (JUN 1997) (a) The Government requires delivery to be made according to the following schedule: REQUIRED DELIVERY SCHEDULE...

The Association of Health Insurance with institutional delivery and access to skilled birth attendants: evidence from the Kenya Demographic and health survey 2008-09.

Science.gov (United States)

Were, Lawrence P O; Were, Edwin; Wamai, Richard; Hogan, Joseph; Galarraga, Omar

2017-07-03

Healthcare financing through health insurance is gaining traction as developing countries strive to achieve universal health coverage and address the limited access to critical health services for specific populations including pregnant women and their children. However, these reforms are taking place despite limited evaluation of impact of health insurance on maternal health in developing countries including Kenya. In this study we evaluate the association of health insurance with access and utilization of obstetric delivery health services for pregnant women in Kenya. Nationally representative data from the Kenya Demographic and Health Survey 2008-09 was used in this study. 4082 pregnant women with outcomes of interest - Institutional delivery (Yes/No - delivery at hospital, dispensary, maternity home, and clinic) and access to skilled birth attendants (help by a nurse, doctor, or trained midwife at delivery) were selected from 8444 women ages 15-49 years. Linear and logistic regression, and propensity score adjustment are used to estimate the causal association of enrollment in insurance on obstetric health outcomes. Mothers with insurance are 23 percentage points (p insured. In addition mothers of lower socio-economic status benefit more from enrollment in insurance compared to mothers of higher socio-economic status. For both institutional delivery and access to skilled birth attendants, the average difference of the association of insurance enrollment compared to not enrolling for those of low SES is 23 percentage points (p health insurance is associated with increased access and utilization of obstetric delivery health services for pregnant women. Notably, those of lower socio-economic status seem to benefit the most from enrollment in insurance.

Nanoscale drug delivery for targeted chemotherapy.

Science.gov (United States)

Xin, Yong; Huang, Qian; Tang, Jian-Qin; Hou, Xiao-Yang; Zhang, Pei; Zhang, Long Zhen; Jiang, Guan

2016-08-28

Despite significant improvements in diagnostic methods and innovations in therapies for specific cancers, effective treatments for neoplastic diseases still represent major challenges. Nanotechnology as an emerging technology has been widely used in many fields and also provides a new opportunity for the targeted delivery of cancer drugs. Nanoscale delivery of chemotherapy drugs to the tumor site is highly desirable. Recent studies have shown that nanoscale drug delivery systems not only have the ability to destroy cancer cells but may also be carriers for chemotherapy drugs. Some studies have demonstrated that delivery of chemotherapy via nanoscale carriers has greater therapeutic benefit than either treatment modality alone. In this review, novel approaches to nanoscale delivery of chemotherapy are described and recent progress in this field is discussed. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Nanoparticles for intracellular-targeted drug delivery

International Nuclear Information System (INIS)

Paulo, Cristiana S O; Pires das Neves, Ricardo; Ferreira, Lino S

2011-01-01

Nanoparticles (NPs) are very promising for the intracellular delivery of anticancer and immunomodulatory drugs, stem cell differentiation biomolecules and cell activity modulators. Although initial studies in the area of intracellular drug delivery have been performed in the delivery of DNA, there is an increasing interest in the use of other molecules to modulate cell activity. Herein, we review the latest advances in the intracellular-targeted delivery of short interference RNA, proteins and small molecules using NPs. In most cases, the drugs act at different cellular organelles and therefore the drug-containing NPs should be directed to precise locations within the cell. This will lead to the desired magnitude and duration of the drug effects. The spatial control in the intracellular delivery might open new avenues to modulate cell activity while avoiding side-effects.

Drug delivery across length scales.

Science.gov (United States)

Delcassian, Derfogail; Patel, Asha K; Cortinas, Abel B; Langer, Robert

2018-02-20

Over the last century, there has been a dramatic change in the nature of therapeutic, biologically active molecules available to treat disease. Therapies have evolved from extracted natural products towards rationally designed biomolecules, including small molecules, engineered proteins and nucleic acids. The use of potent drugs which target specific organs, cells or biochemical pathways, necessitates new tools which can enable controlled delivery and dosing of these therapeutics to their biological targets. Here, we review the miniaturisation of drug delivery systems from the macro to nano-scale, focussing on controlled dosing and controlled targeting as two key parameters in drug delivery device design. We describe how the miniaturisation of these devices enables the move from repeated, systemic dosing, to on-demand, targeted delivery of therapeutic drugs and highlight areas of focus for the future.

Effect of induction-delivery and uterine-delivery on apgar scoring of the newborn.

Directory of Open Access Journals (Sweden)

Kamat S

1991-07-01

Full Text Available Very short or prolonged induction-delivery interval (i.e. less than 5 minutes or more than 15 minutes and uterine-delivery interval of more than 90 seconds has a definite effect on the apgar scoring of a newborn especially when general anaesthesia is administered as compared to regional anaesthesia for caesarean section.

New England observed and predicted July stream/river temperature daily range points

Data.gov (United States)

U.S. Environmental Protection Agency — The shapefile contains points with associated observed and predicted July stream/river temperature daily ranges in New England based on a spatial statistical network...

[Beneficial effect of maternity leave on delivery].

Science.gov (United States)

Xu, Qian; Séguin, Louise; Goulet, Lise

2002-01-01

To identify the contribution of the duration of the prenatal maternity leave on term delivery. Characteristics of the prenatal maternity leave and delivery among 363 working women who had delivered a full-term infant at 1 of 4 hospitals in Montreal during 1996 were studied. The presence of an intervention or complication during delivery was observed in 68.9% of the participants. The average duration of the prenatal maternity leave was about 8 weeks (SD = 7). The adjusted risk of a difficult delivery decreased significantly with the duration of the prenatal maternity leave (OR = 0.96; 95% CI: 0.93-0.99). The duration of the maternity leave before delivery is associated with an easier term delivery for working women.

Redefining continuing education delivery.

Science.gov (United States)

Carlton, K H

1997-01-01

Just as technology is transforming the delivery of education, the Internet and advanced telecommunication applications are changing the "face" of CE and the connotation of "lifelong learning." As late as the mid-1980s, a discussion of computer applications in nursing CE focused on the "timely" transition to microcomputers as tools for the enhancement of managerial tasks for increased productivity. Even as recently as 1990, there seemed to be "time" for those providers who were "slower to adopt innovation" to "catch up." Now, the CE provider who does not integrate the microcomputer and advanced telecommunications as an integral component of their delivery modalities may be outsourced rapidly by an educational or commercial competitive unit that is able to utilize the communication medium, mergers and partnerships, enterprise, and individual lifestyle and learning patterns that will epitomize the CE unit of the 21st century. As with the "re-engineering" of nursing education, the "re-engineered" delivery modalities of evolving CE entity might now best be conceptualized on a continuum from the traditional mode that time and place dependent to a mode of synchronous and asynchronous data and advanced telecommunication. Delivery methods will need to be selected according to the target populations, content, and situation. The health-care educational provider may discover, as in other industries, that a combination of distance and residential offerings will be the most successful medium for the delivery of CE to the progressively more "information and technologically savvy" lifelong learner of the 21st century. In addressing the dramatic effects of the information technology era on the refocused multimedia/interactive delivery method for student education, educators amply quoted Bob Dylan's phrase of the 1960s, "The times, they are a-changing." And so, we see that the times are also changing at an astronomical rate for the health-care educational provider as well as the

The life cycle cost of a building from the point of view of environmental criteria of selecting the most beneficial offer in the area of competitive tendering

Directory of Open Access Journals (Sweden)

Grzyl Beata

2017-01-01

Full Text Available The article analyses environmental and ecological criteria of selecting the most beneficial offer in the aspect of LCC. Construction works contracts and the potential method of defining the above criteria, among others, is pondered on (for example by the recommendation of a material, which is supposed to be used, a ban on substances that are harmful for human health as well for the environment. In the relation to the above, it is necessary to define technical parameters that have an impact on the environment, for example the level of pollution and noise emission, electricity and water consumption, or stating the minimal involvement of a processed ingredient. In addition the article presents also an account of the life cycle cost of a building from the point of view of environmental criteria constituting an element of selecting the most beneficial offer in the area of competitive tendering.

Environmental offences in 1995. An evaluation of statistics

International Nuclear Information System (INIS)

Goertz, M.; Werner, J.; Sanchez de la Cerda, J.; Schwertfeger, C.; Winkler, K.

1997-01-01

This publication deals with the execution of environmental criminal law. On the basis of police and judicial statistics it is pointed out how often an environmental criminal offence was at least suspected by the police or law courts, how they reacted to their suspicion, which individual environmental criminal offences were committed particularly frequently, and what segment of the population the typical perpetrator belonged to. (orig./SR) [de

Permeation enhancer strategies in transdermal drug delivery.

Science.gov (United States)

Marwah, Harneet; Garg, Tarun; Goyal, Amit K; Rath, Goutam

2016-01-01

Today, ∼74% of drugs are taken orally and are not found to be as effective as desired. To improve such characteristics, transdermal drug delivery was brought to existence. This delivery system is capable of transporting the drug or macromolecules painlessly through skin into the blood circulation at fixed rate. Topical administration of therapeutic agents offers many advantages over conventional oral and invasive techniques of drug delivery. Several important advantages of transdermal drug delivery are prevention from hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug. Human skin surface, as a site of drug application for both local and systemic effects, is the most eligible candidate available. New controlled transdermal drug delivery systems (TDDS) technologies (electrically-based, structure-based and velocity-based) have been developed and commercialized for the transdermal delivery of troublesome drugs. This review article covers most of the new active transport technologies involved in enhancing the transdermal permeation via effective drug delivery system.

Experience from the development of Point Lepreau's training program for technical support staff

International Nuclear Information System (INIS)

Turner, S.; Scott, K.

2007-01-01

The Training Department at the Point Lepreau GS has been developing and improving its training for technical support staff. A generic set of objectives are being used as the basis for a systematic approach to training. The program covers general and job specific knowledge and skills using a mix of classroom instruction, mentoring and continuing training seminars. This paper describes experience, success and the challenges in the development, delivery and evaluation of the training program. (author)

Technical Data Management Center: a focal point for meteorological and other environmental transport computing technology

International Nuclear Information System (INIS)

McGill, B.; Maskewitz, B.F.; Trubey, D.K.

1981-01-01

The Technical Data Management Center, collecting, packaging, analyzing, and distributing information, computer technology and data which includes meteorological and other environmental transport work is located at the Oak Ridge National Laboratory, within the Engineering Physics Division. Major activities include maintaining a collection of computing technology and associated literature citations to provide capabilities for meteorological and environmental work. Details of the activities on behalf of TDMC's sponsoring agency, the US Nuclear Regulatory Commission, are described

SEAFP and SEAL: safety and environmental aspects

International Nuclear Information System (INIS)

Gulden, W.; Raeder, J.; Cook, I.

2000-01-01

The Safety and Environmental Assessment of Fusion Power (SEAFP) programme undertaken in the period 1992-1995 formed part of the ongoing effort in the European Fusion Programme to consider the safety and environmental aspects of fusion power. The assessment started with the development of a tokamak fusion power plant model of 3000 MW of fusion power. The analyses of safety included detailed consideration of effluents from normal operation, occupational doses, accidents (concentrating on the worst possible), and waste management. SEAFP was also the starting point for the Safety and Environmental Assessment of Fusion Power -- Long Term Programme (SEAL) initiated within the European Fusion Programme in 1995. SEAL aims at broadening the scope and elaborating selected aspects in more detail. SEAFP and SEAL confirmed the favourable safety and environmental characteristics of fusion power. They also confirmed the need to support these characteristics by dedicated materials development and safety-related design decisions. Recently, a new study on fusion safety (SEAFP-2) has been launched, defined for the time period 1997-1998, using SEAFP and SEAL findings as starting points

Nanotechnology-based drug delivery systems

Directory of Open Access Journals (Sweden)

Singh Baljit

2007-12-01

Full Text Available Abstract Nanoparticles hold tremendous potential as an effective drug delivery system. In this review we discussed recent developments in nanotechnology for drug delivery. To overcome the problems of gene and drug delivery, nanotechnology has gained interest in recent years. Nanosystems with different compositions and biological properties have been extensively investigated for drug and gene delivery applications. To achieve efficient drug delivery it is important to understand the interactions of nanomaterials with the biological environment, targeting cell-surface receptors, drug release, multiple drug administration, stability of therapeutic agents and molecular mechanisms of cell signalling involved in pathobiology of the disease under consideration. Several anti-cancer drugs including paclitaxel, doxorubicin, 5-fluorouracil and dexamethasone have been successfully formulated using nanomaterials. Quantom dots, chitosan, Polylactic/glycolic acid (PLGA and PLGA-based nanoparticles have also been used for in vitro RNAi delivery. Brain cancer is one of the most difficult malignancies to detect and treat mainly because of the difficulty in getting imaging and therapeutic agents past the blood-brain barrier and into the brain. Anti-cancer drugs such as loperamide and doxorubicin bound to nanomaterials have been shown to cross the intact blood-brain barrier and released at therapeutic concentrations in the brain. The use of nanomaterials including peptide-based nanotubes to target the vascular endothelial growth factor (VEGF receptor and cell adhesion molecules like integrins, cadherins and selectins, is a new approach to control disease progression.

SU-E-T-151: Breathing Synchronized Delivery (BSD) Planning for RapicArc Treatment

International Nuclear Information System (INIS)

Lu, W; Chen, M; Jiang, S

2015-01-01

Purpose: To propose a workflow for breathing synchronized delivery (BSD) planning for RapicArc treatment. Methods: The workflow includes three stages: screening/simulation, planning, and delivery. In the screening/simulation stage, a 4D CT with the corresponding breathing pattern is acquired for each of the selected patients, who are able to follow their own breathing pattern. In the planning stage, one breathing phase is chosen as the reference, and contours are delineated on the reference image. Deformation maps to other phases are performed along with contour propagation. Based on the control points of the initial 3D plan for the reference phase and the respiration trace, the correlation with respiration phases, the leaf sequence and gantry angles is determined. The beamlet matrices are calculated with the corresponding breathing phase and deformed to the reference phase. Using the 4D dose evaluation tool and the original 3D plan DVHs criteria, the leaf sequence is further optimized to meet the planning objectives and the machine constraints. In the delivery stage, the patients are instructed to follow the programmed breathing patterns of their own, and all other parts are the same as the conventional Rapid-Arc delivery. Results: Our plan analysis is based on comparison of the 3D plan with a static target (SD), 3D plan with motion delivery (MD), and the BSD plan. Cyclic motion of range 0 cm to 3 cm was simulated for phantoms and lung CT. The gain of the BSD plan over MD is significant and concordant for both simulation and lung 4DCT, indicating the benefits of 4D planning. Conclusion: Our study shows that the BSD plan can approach the SD plan quality. However, such BSD scheme relies on the patient being able to follow the same breathing curve that is used in the planning stage during radiation delivery. Funded by Varian Medical Systems

Epidemiologic Tools to Study the Influence of Environmental Factors on Fecundity and Pregnancy-related Outcomes

Science.gov (United States)

Slama, Rémy; Ballester, Ferran; Casas, Maribel; Cordier, Sylvaine; Eggesbø, Merete; Iniguez, Carmen; Nieuwenhuijsen, Mark; Philippat, Claire; Rey, Sylvie; Vandentorren, Stéphanie; Vrijheid, Martine

2014-01-01

Adverse pregnancy outcomes entail a large health burden for the mother and offspring; a part of it might be avoided by better understanding the role of environmental factors in their etiology. Our aims were to review the assessment tools to characterize fecundity troubles and pregnancy-related outcomes in human populations and their sensitivity to environmental factors. For each outcome, we reviewed the possible study designs, main sources of bias, and their suggested cures. In terms of study design, for most pregnancy outcomes, cohorts with recruitment early during or even before pregnancy allow efficient characterization of pregnancy-related events, time-varying confounders, and in utero exposures that may impact birth outcomes and child health. Studies on congenital anomalies require specific designs, assessment of anomalies in medical pregnancy terminations, and, for congenital anomalies diagnosed postnatally, follow-up during several months after birth. Statistical analyses should take into account environmental exposures during the relevant time windows; survival models are an appropriate approach for fecundity, fetal loss, and gestational duration/preterm delivery. Analysis of gestational duration could distinguish pregnancies according to delivery induction (and possibly pregnancy-related conditions). In conclusion, careful design and analysis are required to better characterize environmental effects on human reproduction. PMID:24363355

Measurement and estimation of dew point for SNG. [Comparison of calculated and measured values

Energy Technology Data Exchange (ETDEWEB)

Furuyama, Y.

1974-08-01

Toho Gas measured and estimated SNG dew points in high-pressure deliveries by calculating the theoretical values by the high-pressure gas-liquid equilibrium theory using the pressure-extrapolation method to reach K = 1, and the BWR method to estimate fugacity, then verifying these values experimentally. The experimental values were measured at 161.7 to 367.5 psi using the conventional static and circulation methods, in addition to a newly developed method consisting of circulating a known composition of gas mixtures, partially freezing them, and monitoring the dew point by observing the droplets on a mirror cooled by blowing liquid nitrogen. Good agreement was found between the calculated and the experimental values.

Evaluation of Aerosol Delivery of Nanosuspension for Pre-clinical Pulmonary Drug Delivery

Directory of Open Access Journals (Sweden)

Chiang Po-Chang

2009-01-01

Full Text Available Abstract Asthma and chronic obstructive pulmonary disease (COPD are pulmonary diseases that are characterized by inflammatory cell infiltration, cytokine production, and airway hyper-reactivity. Most of the effector cells responsible for these pathologies reside in the lungs. One of the most direct ways to deliver drugs to the target cells is via the trachea. In a pre-clinical setting, this can be achieved via intratracheal (IT, intranasal (IN, or aerosol delivery in the desired animal model. In this study, we pioneered the aerosol delivery of a nanosuspension formulation in a rodent model. The efficiency of different dosing techniques and formulations to target the lungs were compared, and fluticasone was used as the model compound. For the aerosol particle size determination, a ten-stage cascade impactor was used. The mass median aerodynamic diameter (MMAD was calculated based on the percent cumulative accumulation at each stage. Formulations with different particle size of fluticasone were made for evaluation. The compatibility of regular fluticasone suspension and nanosuspension for aerosol delivery was also investigated. The in vivo studies were conducted on mice with optimized setting. It was found that the aerosol delivery of fluticasone with nanosuspension was as efficient as intranasal (IN dosing, and was able to achieve dose dependent lung deposition.

Oral delivery of peptides and proteins using lipid-based drug delivery systems