WorldWideScience

Sample records for delivery point environmental

  1. EPA Region 1 Environmentally Sensitive Areas (Points)

    Data.gov (United States)

    U.S. Environmental Protection Agency — This coverage represents point equivalents of environmentally sensitive areas in EPA New England. This coverage represents polygon equivalents of environmentally...

  2. Waste Feed Delivery Environmental Permits and Approvals Plan

    Energy Technology Data Exchange (ETDEWEB)

    TOLLEFSON, K.S.

    2000-01-18

    This plan describes the environmental permits approvals, and other requirements that may affect establishment of a waste feed delivery system for the Hanford Site's River Protection Project. This plan identifies and screens environmental standards for potential applicability, outlines alternatives for satisfying applicable standards, and describes preferred permitting and approval approaches.

  3. Identifying populations at risk from environmental contamination from point sources

    OpenAIRE

    Williams, F; Ogston, S

    2002-01-01

    Objectives: To compare methods for defining the population at risk from a point source of air pollution. A major challenge for environmental epidemiology lies in correctly identifying populations at risk from exposure to environmental pollutants. The complexity of today's environment makes it essential that the methods chosen are accurate and sensitive.

  4. Selection of reproductive health end points for environmental risk assessment.

    OpenAIRE

    Savitz, D A; Harlow, S D

    1991-01-01

    In addition to the challenges inherent in environmental health risk assessment, the study of reproductive health requires thorough consideration of the very definition of reproductive risk. Researchers have yet to determine which end points need to be considered to comprehensively evaluate a community's reproductive health. Several scientific issues should be considered in the selection of end points: the severity of the outcomes, with a trade-off between clinical severity and statistical or ...

  5. 75 FR 24997 - FPL Energy Point Beach, LLC; Point Beach Nuclear Plant, Units 1 and 2; Environmental Assessment...

    Science.gov (United States)

    2010-05-06

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION FPL Energy Point Beach, LLC; Point Beach Nuclear Plant, Units 1 and 2; Environmental Assessment... Energy Point Beach, LLC (the licensee), for operation of the Point Beach Nuclear Plant, Units 1 and 2...

  6. The Impact of the Delivery of Prepared Power Point Presentations on the Learning Process

    Directory of Open Access Journals (Sweden)

    Auksė Marmienė

    2011-04-01

    Full Text Available This article describes the process of the preparation and delivery of Power Point presentations and how it can be used by teachers as a resource for classroom teaching. The advantages of this classroom activity covering some of the problems and providing a few suggestions for dealing with those difficulties are also outlined. The major objective of the present paper is to investigate the students ability to choose the material and the content of Power Point presentations on professional topics via the Internet as well as the ability to prepare and deliver the presentation in front of the audience. The factors which determine the choice of the presentation subject are also analysed in this paper. After the delivery students were requested to self- and peer-assess the difficulties they faced in preparation and performance of the presentations by writing the reports. Learners’ attitudes to the choice of the topic of Power Point presentations were surveyed by administering a self-assessment questionnaire.

  7. Analysis of calibration interval of turbine meters used in natural gas delivery points

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, Fernanda M. [TBG - Transportadora Brasileira Gasoguto Bolivia Brasil, Campinas, SP (Brazil)

    2009-12-19

    In natural gas pipeline operation, an accurate measurement of flow at delivery points provides the basis for the company billing and ensures a relationship of credibility with customers. So, the measurement management system must ensure that the equipment responsible for natural gas measurement is calibrated, although it does not mean that a high frequency of calibration must be adopted, since the calibration costs may increase without relevant gains being perceived. Therefore studying calibration frequency becomes really important in order to find the optimal point between reliability and cost. This paper aimed to evaluate the calibration frequency of the turbine flow meters used in TBG - Transportadora Brasileira Gasoduto Bolivia Brasil to measure processed gas flow at delivery points. Historical calibration data were used in commercial statistical software, which is normally used for lifetime analysis of equipment. Following such procedure, each time a meter was rejected at a calibration, it was considered a fail. The results obtained indicate that the tow year calibration interval used by TBG ensures the probability of failure, translated by the probability of producing incorrect results, of only 3%, considering their process conditions. (author)

  8. 75 FR 14206 - FPL Energy Point Beach, LLC; Point Beach Nuclear Plant, Units 1 and 2; Environmental Assessment...

    Science.gov (United States)

    2010-03-24

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION [Docket Nos. 50-266 And 50-301; NRC-2010-0123 FPL Energy Point Beach, LLC; Point Beach Nuclear Plant, Units 1 and 2; Environmental Assessment and Finding of No Significant Impact The U.S. Nuclear...

  9. Does problem complexity matter for environmental policy delivery? How public authorities address problems of water governance.

    Science.gov (United States)

    Kirschke, Sabrina; Newig, Jens; Völker, Jeanette; Borchardt, Dietrich

    2017-03-08

    Problem complexity is often assumed to hamper effective environmental policy delivery. However, this claim is hardly substantiated, given the dominance of qualitative small-n designs in environmental governance research. We studied 37 types of contemporary problems defined by German water governance to assess the impact of problem complexity on policy delivery through public authorities. The analysis is based on a unique data set related to these problems, encompassing both in-depth interview-based data on complexities and independent official data on policy delivery. Our findings show that complexity in fact tends to delay implementation at the stage of planning. However, different dimensions of complexity (goals, variables, dynamics, interconnections, and uncertainty) impact on the different stages of policy delivery (goal formulation, stages and degrees of implementation) in various ways.

  10. 77 FR 61632 - Final Environmental Impact Statement for Cattle Point Road Relocation, San Juan Island National...

    Science.gov (United States)

    2012-10-10

    ... National Park Service Final Environmental Impact Statement for Cattle Point Road Relocation, San Juan.... ACTION: Notice of Availability of the Final Environmental Impact Statement for Cattle Point Road... bluff erosion that threatens a segment of the Cattle Point Road located in San Juan Island...

  11. Environmental Action Memorandum : [Ottawa and Cedar Point National Wildlife Refuges Fishery Management Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Environmental Action memorandum for the Ottawa and Cedar Point NWRs Fishery Management Plan states that the Plan is found not to have significant environmental...

  12. Environmental implications of wireless technologies: news delivery and business meetings.

    Science.gov (United States)

    Toffel, Michael W; Horvath, Arpad

    2004-06-01

    Wireless information technologies are providing new ways to communicate, and are one of several information and communication technologies touted as an opportunity to reduce society's overall environmental impacts. However, rigorous system-wide environmental impact comparisons of these technologies to the traditional applications they may replace have only recently been initiated, and the results have been mixed. In this paper, the environmental effects of two applications of wireless technologies are compared to those of conventional technologies for which they can substitute. First, reading newspaper content on a personal digital assistant (PDA) is compared to the traditional way of reading a newspaper. Second, wireless teleconferencing is compared to business travel. The results show that for both comparisons wireless technologies create lower environmental impacts. Compared to reading a newspaper, receiving the news on a PDA wirelessly results in the release of 32-140 times less CO2, several orders of magnitude less NOx and SOx, and the use of 26-67 times less water. Wireless teleconferencing results in 1-3 orders of magnitude lower CO2, NOx, and SO2 emissions than business travel.

  13. Study of the critical points of HPMC hydrophilic matrices for controlled drug delivery.

    Science.gov (United States)

    Miranda, Antonia; Millán, Mónica; Caraballo, Isidoro

    2006-03-27

    The knowledge of the percolation thresholds of a system results in a clear improvement of the design of controlled release dosage forms such as inert matrices. Despite hydrophilic matrices are one of the most used controlled delivery systems in the world, but actuality, the mechanisms of drug release from these systems continue to be a matter of debate nowadays. The objective of the present paper is to apply the percolation theory to study the release and hydration rate of hydrophilic matrices. Matrix tablets have been prepared using KCl as a drug model and HPMC K4M as matrix-forming material, employing five different excipient/drug particle size ratios (ranging from 0.42 to 2.33). The formulations studied containing a drug loading in the range of 20-90% (w/w). Dissolution studies were carried out using the paddle method and the water uptake measurements were performed using a modified Enslin apparatus. In order to estimate the percolation threshold, the behaviour of the kinetic parameters with respect to the volumetric fraction of each component at time zero, was studied. The percolation theory has been applied for the first time to the study of matrix type controlled delivery systems. The application of this theory allowed to explain changes in the release and hydration kinetics of these matrices. The critical points observed in dissolution and water uptake studies can be attributed to the excipient percolation threshold, being this threshold one of the main factors governing the gel layer formation and consequently, the drug release control from hydrophilic matrices.

  14. Study of environmental, social, and paternal factors in preterm delivery using sibs and half sibs

    DEFF Research Database (Denmark)

    Basso, Olga; Olsen, Jørn; Christensen, Kaare

    1999-01-01

    Objective—The aim of this study was to evaluate the influence on preterm delivery of changes in putative genetic and environmental risk factors between two consecutive births. Low social status is a suspected risk indicator of preterm delivery, but the impact of social mobility has not been studied...... weeks of gestation and had a subsequent live born child in the same time period formed the cohorts. Methods—The risk of having a premature infant in the subsequent pregnancy was analysed in each cohort as a function of changes in male partner, residency, occupation, and social status between the two...... pregnancies. Results—There was a strong tendency to repeat a preterm delivery (18% v 6% in the general population). Social decline was associated with a moderate increase in the recurrence risk (OR: 1.22; 95% CI: 1.02, 1.47). In the reference cohort the risk of preterm delivery associated with changing from...

  15. Relationship among Environmental Pointing Accuracy, Mental Rotation, Sex, and Hormones

    Science.gov (United States)

    Bell, Scott; Saucier, Deborah

    2004-01-01

    Humans rely on internal representations to solve a variety of spatial problems including navigation. Navigation employs specific information to compose a representation of space that is distinct from that obtained through static bird's-eye or horizontal perspectives. The ability to point to on-route locations, off-route locations, and the route…

  16. Environmental Worldviews: A Point of Common Contact, or Barrier?

    Directory of Open Access Journals (Sweden)

    Mark W. Anderson

    2013-11-01

    Full Text Available Increasingly, scientists are reaching out to individuals and entities once considered “users” of scientific knowledge to engage them in the research process due to the increased need for contextualized knowledge. However, these increased interactions make apparent the boundaries that exist between the parties interested in sustainability science. Divergent values and attitudes amongst researchers and between researchers and stakeholders may preclude effective communication and collaboration when individuals screen information due to their perceptions of those who generated the information. The current work contributes to the complexity of environmental communication in the decision making sphere, by considering whether expressions of personal value, such as environmental worldviews, may influence the processing of knowledge and information sharing across interdisciplinary research and researcher–stakeholder boundaries. This work includes a unique opportunity to consider not only empirical data, but interactions and implications within a research community and with the public.

  17. Agent for environmental protection. Liability and points of Criminal Law

    Energy Technology Data Exchange (ETDEWEB)

    Keune, H.

    1981-06-01

    The author discusses the concept and status of the agent for environment protection on the basis of the relevant laws because a legal definition does not yet exist. The administrative body accepts the so-called Janus-faced industrial agent who has, as a rule, also the function of the agent for environmental protection, namely, because of the principle of concentration that has greatly been accepted because of rationalizing and efficiency reasons. As a consequence of this principle the so-exposed agent bears an 'outward' responsibility. The criminal liability of the agent for environmental protection is discussed under the aspects of acts performed on behalf of somebody else, the acceptance of responsability for one's own act or omission, the comittment by omitting, the indirect perpetration and the complicity. Furthermore the author looks into the following subjects: protection against work that is liable to be dangerous, claim for compensation under civil law and the new regulations of the German Penal Code that determine what is environmentally criminal.

  18. Environmental and Public Health Issues of Animal Food Products Delivery System in Imo State, Nigeria

    Directory of Open Access Journals (Sweden)

    Opara Maxwell Nwachukwu

    2006-05-01

    Full Text Available Information on livestock movement, animal food products processing facilities, meat inspection methods, official meat inspection records and distribution and marketing systems for processed products in Imo state, Nigeria needed for policy development interventions in the sector are not fully understood. The primary data generated with the aid of personal interviews, field observations and secondary data obtained from records accumulated by the department of veterinary services Imo state from 2001 to 2004 were used to investigate the environmental and public health issues of animal food products delivery system in state. Majority of trade animals supplied to the state originated from the northern states of the country and were brought in with trucks by road. Only two veterinary control posts served the whole state thus resulting in non-inspection and taxing of a large proportion of trade animals. Official record of trade animals supplied to the state from 2001 to 2004 ranged from 45000 – 144000 for cattle, 23000 – 96000 for goats and 11000 – 72000 for sheep per annum, with supplies increasing steadily across the years. Official slaughter points in the state were principally low-grade quality slaughter premises consisting of a thin concrete slab. Meat handling was very unhygienic with carcasses dressed beside refuse heaps of over 2 years standing. Carcasses were dragged on the ground and transported in taxi boots and open trucks. Meat inspection at these points was not thorough because of stiff resistance of butchers to carcass condemnation. Official meat inspection records for the state from 2001 to 2004 revealed that overall totals of 159,000 cattle, 101,000 goats and 67,000 sheep were slaughtered. This accounted for about 56, 57 and 57% shortfall of cattle, goat and sheep respectively supplied to the state and represents the volume of un-inspected animals during the study period. Fascioliasis and tuberculosis were the most common

  19. Environmental Assessment: Gulf Power Company Military Point Transmission Line Project

    Science.gov (United States)

    2014-05-12

    medium-sized mammals , a variety of reptilian and amphibian species, and a large diversity of water and terrestrial bird species (Tyndall AFB 1999...John Dingwall Project Manager 325th Civil Engineer Squadron 119 Alabama Avenue People Serving Peopfeu Re: Gulf Power Company Military Point...Force 3251h Civil Engineer Squadron 119 Alabama Avenue Tyndall AFB, FL 32403-5014 Dear Mr. Dingwall: I have revieweKI the proposal for Gulf Power

  20. Stress Points to Energy Saving and Environmental Protection

    Institute of Scientific and Technical Information of China (English)

    Fang Weizhong; Jin Wen

    2007-01-01

    @@ GDP growth of 10.5% in 2006 can't be admired without analysis. The growth of 2.5 percentage points beyond the state's plan was achieved on the costs that energy consumption remained at a high increase rate of 11% and the total discharge amount of main pollutants increased but decreased. To balance out the gain against the loss,the gain is unlikely to outweigh the loss.

  1. 78 FR 58570 - Environmental Assessment; Entergy Nuclear Operations, Inc., Big Rock Point

    Science.gov (United States)

    2013-09-24

    ... COMMISSION Environmental Assessment; Entergy Nuclear Operations, Inc., Big Rock Point AGENCY: Nuclear... Nuclear Operations, Inc. (ENO) (the applicant or the licensee), for the Big Rock Point (BRP) Independent... for Production and Utilization Facilities,'' for the Big Rock Point (BRP) Independent Spent...

  2. Implications for the inter-organizational design of environmental care when changing environmental control points

    NARCIS (Netherlands)

    Hagelaar, J.L.F.; Seuring, S.

    2006-01-01

    In this paper we try to bridge the gap between two lines of thought within the environmental care literature. We differentiate between two major clusters in this literature; (1) environmental management and (2) strategic approach to environmental care. Although both approaches focus on the same obje

  3. Detecting critical choke points for achieving Good Environmental Status in European seas

    Directory of Open Access Journals (Sweden)

    Tavis Potts

    2015-03-01

    Full Text Available Choke points are social, cultural, political, institutional, or psychological obstructions of social-ecological systems that constrain progress toward an environmental objective. Using a soft systems methodology, different types of chokes points were identified in the Outer Hebrides of Scotland, the Baltic, and the North and Mediterranean seas. The choke points were of differing types: cultural and political choke points were identified in Barra and the Mediterranean, respectively, whereas the choke points in the North Sea and Baltic Sea were dependent on differing values toward the mitigation of eutrophication. We conclude with suggestions to identify and address choke points.

  4. Historic cohort study on mode of delivery of a macrosomic baby: the women's point of view.

    Science.gov (United States)

    Vercellini, Paolo; Fumagalli, Monica; Consonni, Dario; de Braud, Lucrezia; Barbara, Giussy; Iurlaro, Enrico; Mosca, Fabio; Fedele, Luigi

    2015-11-01

    A historic cohort study was conducted to evaluate satisfaction with childbirth of a macrosomic baby according to mode of delivery. All 559 nulliparous women who delivered a neonate weighing >4000 g between 2008 and 2012 were included. The degree of women's satisfaction with childbirth after elective cesarean, vaginal delivery or cesarean during labor was assessed using a five-level scale. Immediate neonatal and maternal outcomes were retrieved from clinical records. Long-term maternal outcomes were evaluated using four questionnaires on urinary incontinence, anal incontinence, and sexual functioning. Ninety-nine women underwent elective cesarean, whereas 460 attempted a vaginal delivery. In the latter group, 276 women delivered vaginally, whereas 184 underwent a cesarean during labor. Long-term outcomes were assessed in 273 women (49%; elective cesarean, n = 55; vaginal delivery, n = 135; cesarean in labor, n = 83) after a mean 3-year follow up. The proportion of long-term stress or mixed urinary incontinence was, respectively, 8%, 34%, and 12%, whereas that of anal incontinence was 7%, 19%, and 6%. Sexual functioning was similar in the three groups. No major neonatal complications were observed. When pooling the vaginal delivery and the cesarean in labor groups, the likelihood of being satisfied with childbirth was 63% in the "attempted vaginal delivery" group and 85% in the elective cesarean group (adjusted risk ratio, 0.72; 95% CI 0.61-0.84). About one-third of women attempting a vaginal delivery of a macrosomic baby, would choose an elective cesarean if they could turn back time. © 2015 Nordic Federation of Societies of Obstetrics and Gynecology.

  5. Control Point Analysis comparison for 3 different treatment planning and delivery complexity levels using a commercial 3-dimensional diode array

    Energy Technology Data Exchange (ETDEWEB)

    Abdellatif, Ady, E-mail: ady.abdellatif@lhsc.on.ca [Department of Physics and Engineering, London Regional Cancer Program, London, Ontario (Canada); Gaede, Stewart [Department of Physics and Engineering, London Regional Cancer Program, London, Ontario (Canada); Department of Oncology, Western University, London, Ontario (Canada); Department of Medical Biophysics, Western University, London, Ontario (Canada)

    2014-07-01

    To investigate the use of “Control Point Analysis” (Sun Nuclear Corporation, Melbourne, FL) to analyze and compare delivered volumetric-modulated arc therapy (VMAT) plans for 3 different treatment planning complexity levels. A total of 30 patients were chosen and fully anonymized for the purpose of this study. Overall, 10 lung stereotactic body radiotherapy (SBRT), 10 head-and-neck (H and N), and 10 prostate VMAT plans were generated on Pinnacle{sup 3} and delivered on a Varian linear accelerator (LINAC). The delivered dose was measured using ArcCHECK (Sun Nuclear Corporation, Melbourne, FL). Each plan was analyzed using “Sun Nuclear Corporation (SNC) Patient 6” and “Control Point Analysis.” Gamma passing percentage was used to assess the differences between the measured and planned dose distributions and to assess the role of various control point binning combinations. Of the different sites considered, the prostate cases reported the highest gamma passing percentages calculated with “SNC Patient 6” (97.5% to 99.2% for the 3%, 3 mm) and “Control Point Analysis” (95.4% to 98.3% for the 3%, 3 mm). The mean percentage of passing control point sectors for the prostate cases increased from 51.8 ± 7.8% for individual control points to 70.6 ± 10.5% for 5 control points binned together to 87.8 ± 11.0% for 10 control points binned together (2%, 2-mm passing criteria). Overall, there was an increasing trend in the percentage of sectors passing gamma analysis with an increase in the number of control points binned together in a sector for both the gamma passing criteria (2%, 2 mm and 3%, 3 mm). Although many plans passed the clinical quality assurance criteria, plans involving the delivery of high Monitor Unit (MU)/control point (SBRT) and plans involving high degree of modulation (H and N) showed less delivery accuracy per control point compared with plans with low MU/control point and low degree of modulation (prostate)

  6. Creating the Data Basis for Environmental Evaluations with the Oil Point Method

    DEFF Research Database (Denmark)

    Bey, Niki; Lenau, Torben Anker

    1999-01-01

    In order to support designers in decision-making, some methods have been developed which are based on environmental indicators. These methods, however, can only be used, if indicators for the specific product concept exist and are readily available.Based on this situation, the authors developed...... a simple, indicator-based method for environmental evaluations, the Oil Point Method, which is described in this paper. Oil Points are derived from energy data and refer to kilograms of oil, therefore the name. In the Oil Point Method, a certain degree of inaccuracy is explicitly accepted like...... it is the case with rules-of-thumb. The central idea is that missing indicators can be calculated or estimated by the designers themselves.After discussing energy-related environmental evaluation and arguing for its application in evaluation of concepts, the paper focuses on the basic problem of missing data...

  7. The Hunters Point cogeneration project: Environmental justice in power plant siting

    Energy Technology Data Exchange (ETDEWEB)

    Kosloff, L.H. [Trexler and Associates, Inc., Portland, OR (United States); Varanini, E.E. III [Marron, Reid and Sheehy, Sacramento, CA (United States)

    1997-12-31

    The recent Hunters Point, San Francisco power plant siting process in California represents the first time that environmental justice has arisen as a major power plant siting issue. Intervenors argued that the siting process was racially and economically biased and were supported by leading environmental justice activists at the Golden Gate Law School`s Environmental Justice Clinic, a leading thinker in this field. The applicant argued that environmental justice charges cannot realistically be made against a modern natural-gas energy facility with state-of-the-art environmental controls. The applicant also argued that environmental justice concerns were fully addressed through the extensive environmental and socioeconomic review carried out by California Energy Commission staff. After extensive testimony and cross-examination, the Commission agreed with the applicant. This case has important lessons for companies that could be charged with environmental justice violations and environmental justice activists who must decide where to most effectively target their efforts. This paper reviews the proceeding and its lessons and makes recommendations regarding future applicability of environmental justice issues to the power generation sector. The authors represented the applicant in the facility siting proceeding.

  8. Creating the data basis for environmental evaluations with the Oil Point Method

    DEFF Research Database (Denmark)

    Bey, Niki; Lenau, Torben Anker

    1999-01-01

    A simple, indicator-based method for environmental evaluations, the Oil Point Method, has been developed. Oil Points are derived from energy data and refer to kilograms of oil, therefore the name. In the Oil Point Method, a certain degree of inaccuracy is explicitly accepted like it is the case...... with rules-of-thumb. The central idea is that missing indicators can be calculated or estimated by the designers themselves.After discussing energy-related environmental evaluation and arguing for its application in evaluation of concepts, the paper focuses on the basic problem of missing data and describes...... the way in which the problem may be solved by making Oil Point evaluations. Sources of energy data are mentioned. Typical deficits to be aware of - such as the negligence of efficiency factors - are revealed and discussed. Comparative case studies which have shown encouraging results are mentioned as well....

  9. Rethinking mobile delivery: using Quick Response codes to access information at the point of need.

    Science.gov (United States)

    Lombardo, Nancy T; Morrow, Anne; Le Ber, Jeanne

    2012-01-01

    This article covers the use of Quick Response (QR) codes to provide instant mobile access to information, digital collections, educational offerings, library website, subject guides, text messages, videos, and library personnel. The array of uses and the value of using QR codes to push customized information to patrons are explained. A case is developed for using QR codes for mobile delivery of customized information to patrons. Applications in use at the Libraries of the University of Utah will be reviewed to provide readers with ideas for use in their library.

  10. The patient as the pivot point for quality in health care delivery.

    Science.gov (United States)

    Lengnick-Hall, C A

    1995-01-01

    Health care enterprises make comprehensive and durable changes in people. This human-centered purpose defines the fundamental nature of quality in health care settings. Traditional perspectives of quality and familiar views of customer satisfaction are inadequate to manage the complex relationships between the health care delivery firm and its patients. Patients play four roles in health care systems that must be reflected when defining and measuring quality in these settings: patient as supplier, patient as product, patient as participant, and patient as recipient. This article presents a conceptual model of quality that incorporates these diverse patient roles. The strategic and managerial implications of the model are also discussed.

  11. Point-of-care technology: integration for improved delivery of care.

    Science.gov (United States)

    Gregory, Debbie; Buckner, Martha

    2014-01-01

    The growing complexity of technology, equipment, and devices involved in patient care delivery can be staggering and overwhelming. Technology is intended to be a tool to help clinicians, but it can also be a frustrating hindrance if not thoughtfully planned and strategically aligned. Critical care nurses are key partners in the collaborations needed to improve safety and quality through health information technology (IT). Nurses must advocate for systems that are interoperable and adapted to the context of care experiences. The involvement and collaboration between clinicians, information technology specialists, biomedical engineers, and vendors has never been more relevant and applicable. Working together strategically with a shared vision can effectively provide a seamless clinical workflow, maximize technology investments, and ultimately improve patient care delivery and outcomes. Developing a strategic integrated clinical and IT roadmap is a critical component of today's health care environment. How can technology strategy be aligned from the executive suite to the bedside caregiver? What is the model for using clinical workflows to drive technology adoption? How can the voice of the critical care nurse strengthen this process? How can success be assured from the initial assessment and selection of technology to a sustainable support model? What is the vendor's role as a strategic partner and "co-caregiver"?

  12. Meloxicam transdermal delivery: effect of eutectic point on the rate and extent of skin permeation

    Directory of Open Access Journals (Sweden)

    Soliman Mohammadi-Samani

    2014-02-01

    Conclusion: This study set out to determine that thymol plays as a skin permeation enhancer and increases the meloxicam skin absorption and this enhancement is significant at the eutectic point of drug-enhancer mixture.

  13. Involving the expert in the delivery of environmental information from the web

    Energy Technology Data Exchange (ETDEWEB)

    Wanner, Leo [Catalan Institute for Research and Advanced Studies (ICREA), Barcelona (Spain); Pompeu Fabra Univ., Barcelona (Spain). DTIC; Bosch, Harald; Ertl, Thomas [Stuttgart Univ. (Germany). VIS; Vrochidis, Stefanos; Moumtzidou, Anastasia; Kompatsiaris, Ioannis [Centre for Research and Technology Hellas, Thermi-Thessaloniki (Greece). ITI; Bouayad-Agha, Nadjet; Casamayor, Gerard [Pompeu Fabra Univ., Barcelona (Spain). DTIC; Johansson, Lasse; Karppinen, Ari [Finnish Meteorological Institute, Helsinki (Finland)

    2013-07-01

    Automatic provision of accurate user need- and profile-tailored environmental information is of increasing demand. However, it is a challenging task with many facets. Among them is the difficulty to compile and cast into a formal representation all the expert knowledge needed to accurately and exhaustively acquire, assess and process the data in order to be able to reliably judge their relevance to the user and to produce an adequate summary and recommendations. Studies in Human-Computer Interaction show that both the satisfaction of the users with an application and the objective performance of a service increases if the users (in particular, experts) are assigned an active role in the system. Based on this insight, we propose a largely interactive environmental information acquisition and generation framework, which has been realized in the FP7 project ''Personalized Environmental Service Configuration and Delivery Orchestration'' (PESCaDO). The PESCaDO service involves the experts in four central tasks: (i) determination of criteria for the search of environmental nodes in the web; (ii) assessment of the relevance of the identified nodes; (iii) assessment of the quality of the data provided by the nodes, and (iv) selection of the content to be communicated to the user. Quantitative evaluations and user trials show that the performance of the system is good and the satisfaction with the service is high. (orig.)

  14. 75 FR 4426 - Florida Power and Light Company; Turkey Point Nuclear Generating Units 3 and 4; Environmental...

    Science.gov (United States)

    2010-01-27

    ... the beltline region of the Turkey Point Units 3 and 4 reactor pressure vessels. Environmental Impacts... COMMISSION Florida Power and Light Company; Turkey Point Nuclear Generating Units 3 and 4; Environmental..., located in Miami, Florida. In accordance with 10 CFR 51.21, the NRC prepared an environmental assessment...

  15. Specification of an Information Delivery Tool to Support Optimal Holistic Environmental and Energy Management in Buildings

    Energy Technology Data Exchange (ETDEWEB)

    O' Donnell, James; Keane, Marcus; Bazjanac, Vladimir

    2008-07-01

    Building performance assessment for the operational phase of a building's life cycle is heuristic, typically working from available historical metered data and focusing on bulk energy assessment. Building Management Systems are used in the operational phase of the building to control the building's internal environment according to the design criteria outlined during the design phase. Recent developments in mechanisms that communicate building performance such as standardized building performance objectives and metrics enable the use of the output from whole building energy simulation tools by nontechnical personnel and all project stakeholders. This paper proposes to specify and demonstrate the utilization of an Information Delivery Tool that supports optimum holistic environmental and energy analysis aimed at an established profile of building managers utilizing standardized performance objectives and metrics.

  16. Performance Comparison of Widely-Used Maximum Power Point Tracker Algorithms under Real Environmental Conditions

    Directory of Open Access Journals (Sweden)

    DURUSU, A.

    2014-08-01

    Full Text Available Maximum power point trackers (MPPTs play an essential role in extracting power from photovoltaic (PV panels as they make the solar panels to operate at the maximum power point (MPP whatever the changes of environmental conditions are. For this reason, they take an important place in the increase of PV system efficiency. MPPTs are driven by MPPT algorithms and a number of MPPT algorithms are proposed in the literature. The comparison of the MPPT algorithms in literature are made by a sun simulator based test system under laboratory conditions for short durations. However, in this study, the performances of four most commonly used MPPT algorithms are compared under real environmental conditions for longer periods. A dual identical experimental setup is designed to make a comparison between two the considered MPPT algorithms as synchronized. As a result of this study, the ranking among these algorithms are presented and the results show that Incremental Conductance (IC algorithm gives the best performance.

  17. A projected turning point in China's CO2 emissions - an Environmental Kuznets Curve analysis

    OpenAIRE

    Xu, Bo; Wennersten, Ronald; Brandt, Nils; Sun, Qie

    2012-01-01

    This paper examines the possible existence fan Environmental Kuznets Curve (EKC) relationship between China's carbon dioxide (CO2) emissions per capita (CO2/capita) and GDP per capita (GDP/capita) during the period 1980-2008. The timing of the turning point in China's CO2/capita can be further estimated if an EKC relationship exists. In regression results, a natural logarithm-quadratic relationship was found between CO2/capita and GDP/capita, which supports the EKC hypothesis. However, China'...

  18. Delivery at CERN and installation of the LHC underground refrigerator 1.8K in UX85 (point 8).

    CERN Multimedia

    Caterina BERTONE (TS-IC-HS)

    2004-01-01

    Series of photographs showing the delivery, handling and installation of the LHC cryogenic refrigerator in point 8 (UX85). The LHC cryogenic fluid (liquid helium at 1.9 K) is produced by cryogenic refrigerators (QURC) that are situated in the shafts and in the underground tunnel areas: 8 new units are being installed to reinforce the existing LEP cryogenic units. Each of them has an overall weight of about 25 t, the shape of a huge reversed L, 2-m wide, 7-m long and around 7-m high. Each QURC is installed in a different cavern/pit and is surrounded by a multitude of other services; consequentially it demands a detailed handling study, the procurement/design of dedicated handling tools and several days for installation of any single part.

  19. Environmental tipping points significantly affect the cost-benefit assessment of climate policies.

    Science.gov (United States)

    Cai, Yongyang; Judd, Kenneth L; Lenton, Timothy M; Lontzek, Thomas S; Narita, Daiju

    2015-04-14

    Most current cost-benefit analyses of climate change policies suggest an optimal global climate policy that is significantly less stringent than the level required to meet the internationally agreed 2 °C target. This is partly because the sum of estimated economic damage of climate change across various sectors, such as energy use and changes in agricultural production, results in only a small economic loss or even a small economic gain in the gross world product under predicted levels of climate change. However, those cost-benefit analyses rarely take account of environmental tipping points leading to abrupt and irreversible impacts on market and nonmarket goods and services, including those provided by the climate and by ecosystems. Here we show that including environmental tipping point impacts in a stochastic dynamic integrated assessment model profoundly alters cost-benefit assessment of global climate policy. The risk of a tipping point, even if it only has nonmarket impacts, could substantially increase the present optimal carbon tax. For example, a risk of only 5% loss in nonmarket goods that occurs with a 5% annual probability at 4 °C increase of the global surface temperature causes an immediate two-thirds increase in optimal carbon tax. If the tipping point also has a 5% impact on market goods, the optimal carbon tax increases by more than a factor of 3. Hence existing cost-benefit assessments of global climate policy may be significantly underestimating the needs for controlling climate change.

  20. 75 FR 65373 - Drakes Bay Oyster Company Special Use Permit/Environmental Impact Statement, Point Reyes National...

    Science.gov (United States)

    2010-10-22

    ... National Park Service Drakes Bay Oyster Company Special Use Permit/Environmental Impact Statement, Point... Intent to prepare an Environmental Impact Statement for the Drakes Bay Oyster Company Special Use Permit... Statement (EIS) for the Drakes Bay Oyster Company Special Use Permit, Point Reyes National...

  1. Revisiting Ecosystem Services: Assessment and Valuation as Starting Points for Environmental Politics

    Directory of Open Access Journals (Sweden)

    Adam Jadhav

    2017-09-01

    Full Text Available The paradigm of ecosystem services (ES and the methods of monetary valuation have become boundary objects, spanning disciplines and earning particular purchase in policy circles. However, the notion of ES and ES valuation have also been subjected to multiple critiques, ranging from their varying precision to the potential for neoliberalization of nature. This paper does not attempt to refute such critiques but rather revisits the potentials of the ES paradigm and the specific method of benefit transfer valuation for their utility as a form of environmental politics and sustainability practice. We find they have particular relevance in contexts where “data” are not readily available or are not legible to policy makers as well as where the imperative of “development” remains ideological. We argue for ES assessment and, specifically, rapid ES valuation as a first-pass tactic to inform evaluation of potentially environmentally degrading projects or environmental management. We demonstrate this using a simple benefit transfer analysis to offer an initial evaluation of (wet landscape ES in a lightly touched estuary in Karnataka, India, where a state-backed proposal to develop an industrial shipping port is gathering steam. While we recognize and do not categorically reject critiques of the ES paradigm, we nonetheless argue for valuation as a starting point for politics that highlight and make visible ES benefits and users implicated by “development” and other kinds of environmental change.

  2. A Dynamic Model of the Environmental Kuznets Curve. Turning Point and Public Policy

    Energy Technology Data Exchange (ETDEWEB)

    Egli, H.; Steger, T.M. [CER-ETH Center of Economic Research at ETH Zurich, ZUE F 10, CH-8092 Zurich (Switzerland)

    2007-01-15

    We set up a simple dynamic macroeconomic model with (1) polluting consumption and a preference for a clean environment, (2) increasing returns in abatement giving rise to an EKC and (3) sustained growth resulting from a linear final-output technology. There are two sorts of market failures caused by external effects associated with consumption and environmental effort. The model is employed to investigate the determinants of the turning point and the cost effectiveness of different public policies aimed at a reduction of the environmental burden. Moreover, the model offers a potential explanation of an N-shaped pollution-income relation. It is shown that the model is compatible with most empirical regularities on economic growth and the environment.

  3. Value Assessment at the Point of Care: Incorporating Patient Values throughout Care Delivery and a Draft Taxonomy of Patient Values.

    Science.gov (United States)

    Armstrong, Melissa J; Mullins, C Daniel

    2017-02-01

    Incorporation of patient values is a key element of patient-centered care, but consistent incorporation of patient values at the point of care is lacking. Shared decision making encourages incorporation of patient values in decision making, but associated tools often lack guidance on value assessment. In addition, focusing on patient values relating only to specific decisions misses an opportunity for a more holistic approach to value assessment that could impact other aspects of clinical encounters, including health care planning, communication, and stakeholder involvement. In this commentary, we propose a taxonomy of values underlying patient decision making and provide examples of how these impact provision of health care. The taxonomy describes four categories of patient values: global, decisional, situational, and external. Global values are personal values impacting decision making at a universal level and can include value traits and life priorities. Decisional values are the values traditionally conceptualized in decision making, including considerations such as efficacy, toxicity, quality of life, convenience, and cost. Situational values are values tied to a specific moment in time that modify patients' existing global and decisional values. Finally, discussion of external values acknowledges that many patients consider values other than their own when making decisions. Recognizing the breadth of values impacting patient decision making has implications for both overall health care delivery and shared decision making because value assessments focusing only on decisional values may miss important patient considerations. This draft taxonomy highlights different values impacting decision making and facilitates a more complete value assessment at the point of care. Copyright © 2017 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  4. Multi-point injection: A general purpose delivery system for treatment and containment of hazardous and radiological waste

    Energy Technology Data Exchange (ETDEWEB)

    Kauschinger, J.L. [Ground Environmental Services, Alpharetta, GA (United States); Kubarewicz, J. [Jacobs Engineering, Oak Ridge, TN (United States); Van Hoesen, S.D. [Lockheed Martin Energy Systems, Oak Ridge, TN (United States)

    1997-12-31

    The multi-point injection (MPI) technology is a proprietary jetting process for the in situ delivery of various agents to treat radiological and/or chemical wastes. A wide variety of waste forms can be treated, varying from heterogeneous solid waste dumped into shallow burial trenches, bottom sludge (heel material) inside of underground tanks, and contaminated soils with widely varying soil composition (gravel, silts/clays, soft rock). The robustness of the MPI system is linked to the use of high speed mono-directional jets to deliver various types of agents for a variety of applications, such as: pretreatment of waste prior to insitu vitrification, solidification of waste for creating low conductivity monoliths, oxidants for insitu destruction of organic waste, and grouts for creating barriers (vertical, inclined, and bottom seals). The only strict limitation placed upon the MPI process is that the material can be pumped under high pressure. This paper describes the procedures to inject ordinary grout to form solidified monoliths of solid wastes.

  5. Landfills, Hazardous Waste - WASTE_INDUSTRIAL_IDEM_IN: Industrial Waste Sites in Indiana (Indiana Department of Environmental Management, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — WASTE_INDUSTRIAL_IDEM_IN is a point shapefile that contains industrial waste site locations in Indiana, provided by personnel of Indiana Department of Environmental...

  6. Land Use and Land Cover - BROWNFIELDS_IDEM_IN: Brownfield Locations in Indiana (Indiana Department of Environmental Management, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — BROWNFIELDS_IDEM_IN is a point shapefile that contains brownfield locations in Indiana, provided by personnel of Indiana Department of Environmental Management,...

  7. Landfills - OPEN_DUMPS_IDEM_IN: Open Dump Sites in Indiana (Indiana Department of Environmental Management, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — OPEN_DUMPS_IDEM_IN is a point shapefile that contains open dump site locations in Indiana, provided by personnel of Indiana Department of Environmental Management,...

  8. Environmental effects on recruitment and implications for biological reference points of Eastern Baltic cod (Gadus morhua)

    DEFF Research Database (Denmark)

    Köster, Fritz; Vinther, Morten; MacKenzie, Brian;

    2009-01-01

    stock productivity. Long-term projections suggest that under adverse environmental conditions for reproduction, harvesting at fishing mortality determined as precautionary may not lead to a recovery of the stock to a biomass level considered precautionary. Thus, a revision of either the limit fishing......The decline of the Eastern Baltic cod (Gadus morhua) stock from highest to lowest stock levels on record throughout the 1980s and early 1990s was caused by a combination of recruitment failure and increasing fishing pressure at declining stock sizes. The processes driving the reproductive success...... of limit reference points, but according to long-term simulations also for target fishing mortalities, being central parts of harvest control rules in several management plans....

  9. Cloud point extraction for the determination of copper in environmental samples by flame atomic absorption spectrometry

    Directory of Open Access Journals (Sweden)

    Ardeshir Shokrollahi

    2008-01-01

    Full Text Available A simple cloud point extraction procedure is presented for the preconcentration of copper in various samples. After complexation by 4-hydroxy-2-mercapto-6-propylpyrimidine (PTU, copper ions are quantitatively extracted into the phase rich in Triton X-114 after centrifugation. Methanol acidified with 0.5 mol L-1 HNO3 was added to the surfactant-rich phase prior to its analysis by flame atomic absorption spectrometry (FAAS. Analytical parameters including concentrations for PTU, Triton X-114 and HNO3, bath temperature, centrifugation rate and time were optimized. The influences of the matrix ions on the recoveries of copper ions were investigated. The detection limits (3SDb/m, n=4 of 1.6 ng mL-1 along with enrichment factors of 30 for Cu were achieved. The proposed procedure was applied to the analysis of environmental samples.

  10. Ground Control Point - Wireless System Network for UAV-based environmental monitoring applications

    Science.gov (United States)

    Mejia-Aguilar, Abraham

    2016-04-01

    In recent years, Unmanned Aerial Vehicles (UAV) have seen widespread civil applications including usage for survey and monitoring services in areas such as agriculture, construction and civil engineering, private surveillance and reconnaissance services and cultural heritage management. Most aerial monitoring services require the integration of information acquired during the flight (such as imagery) with ground-based information (such as GPS information or others) for improved ground truth validation. For example, to obtain an accurate 3D and Digital Elevation Model based on aerial imagery, it is necessary to include ground-based information of coordinate points, which are normally acquired with surveying methods based on Global Position Systems (GPS). However, GPS surveys are very time consuming and especially for longer time series of monitoring data repeated GPS surveys are necessary. In order to improve speed of data collection and integration, this work presents an autonomous system based on Waspmote technologies build on single nodes interlinked in a Wireless Sensor Network (WSN) star-topology for ground based information collection and later integration with surveying data obtained by UAV. Nodes are designed to be visible from the air, to resist extreme weather conditions with low-power consumption. Besides, nodes are equipped with GPS as well as Inertial Measurement Unit (IMU), accelerometer, temperature and soil moisture sensors and thus provide significant advantages in a broad range of applications for environmental monitoring. For our purpose, the WSN transmits the environmental data with 3G/GPRS to a database on a regular time basis. This project provides a detailed case study and implementation of a Ground Control Point System Network for UAV-based vegetation monitoring of dry mountain grassland in the Matsch valley, Italy.

  11. 77 FR 59601 - Dominion Cove Point LNG, LP; Notice of Intent To Prepare an Environmental Assessment for the...

    Science.gov (United States)

    2012-09-28

    ... Energy Regulatory Commission Dominion Cove Point LNG, LP; Notice of Intent To Prepare an Environmental... and operation of facilities by Dominion Cove Point LNG, LP (Dominion) in Maryland and Virginia. This... 717b, DOE would authorize the export of natural gas, including liquefied natural gas (LNG),...

  12. Environmental monitoring of phenolic pollutants in water by cloud point extraction prior to micellar electrokinetic chromatography

    Energy Technology Data Exchange (ETDEWEB)

    Stege, Patricia W.; Sombra, Lorena L.; Messina, German A.; Martinez, Luis D. [National University of San Luis, CONICET, INQUISAL, Department of Chemistry, San Luis (Argentina); Silva, Maria F. [Universidad Nacional de Cuyo, Departamento de Biomatematica y Fisicoquimica, Facultad de Ciencias Agrarias, Mendoza (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET), Buenos Aires (Argentina)

    2009-05-15

    Many aromatic compounds can be found in the environment as a result of anthropogenic activities and some of them are highly toxic. The need to determine low concentrations of pollutants requires analytical methods with high sensitivity, selectivity, and resolution for application to soil, sediment, water, and other environmental samples. Complex sample preparation involving analyte isolation and enrichment is generally necessary before the final analysis. The present paper outlines a novel, simple, low-cost, and environmentally friendly method for the simultaneous determination of p-nitrophenol (PNP), p-aminophenol (PAP), and hydroquinone (HQ) by micellar electrokinetic capillary chromatography after preconcentration by cloud point extraction. Enrichment factors of 180 to 200 were achieved. The limits of detection of the analytes for the preconcentration of 50-ml sample volume were 0.10{mu}g L{sup -1} for PNP, 0.20 {mu}g L{sup -1} for PAP, and 0.16{mu}g L{sup -1} for HQ. The optimized procedure was applied to the determination of phenolic pollutants in natural waters from San Luis, Argentina. (orig.)

  13. Mixed environmental quality indexes for hedonic housing price models: an alternative with area-to-point kriging with external drift

    Directory of Open Access Journals (Sweden)

    José-María Montero

    2009-10-01

    Full Text Available (a When environmental variables are included in hedonic house price models, the locations where a property transaction has been taken place are more than those equipped with an environmental monitoring station. (b When environmental variables are numerous, an environmental quality index (EQI is needed. The solution is to interpolate (kriging environmental variables and, subsequently, elaborate an EQI, because of the lower prediction variance. (c Environmental informations can be both objective and subjective. The potential mismatch between the spatial support for both the objective informations and the subjective ones is solved by using a kriging strategy (area-to-point kriging that forces scarce objective environmental informations to be coherent with dense subjective ones. These options for elaborating EQIs are compared in Madrid City (Spain.

  14. Economic-environmental modeling of point source pollution in Jefferson County, Alabama, USA.

    Science.gov (United States)

    Kebede, Ellene; Schreiner, Dean F; Huluka, Gobena

    2002-05-01

    This paper uses an integrated economic-environmental model to assess the point source pollution from major industries in Jefferson County, Northern Alabama. Industrial expansion generates employment, income, and tax revenue for the public sector; however, it is also often associated with the discharge of chemical pollutants. Jefferson County is one of the largest industrial counties in Alabama that experienced smog warnings and ambient ozone concentration, 1996-1999. Past studies of chemical discharge from industries have used models to assess the pollution impact of individual plants. This study, however, uses an extended Input-Output (I-O) economic model with pollution emission coefficients to assess direct and indirect pollutant emission for several major industries in Jefferson County. The major findings of the study are: (a) the principal emission by the selected industries are volatile organic compounds (VOC) and these contribute to the ambient ozone concentration; (b) the direct and indirect emissions are significantly higher than the direct emission by some industries, indicating that an isolated analysis will underestimate the emission by an industry; (c) while low emission coefficient industries may suggest industry choice they may also emit the most hazardous chemicals. This study is limited by the assumptions made, and the data availability, however it provides a useful analytical tool for direct and cumulative emission estimation and generates insights on the complexity in choice of industries.

  15. SU-E-T-56: A Novel Approach to Computing Expected Value and Variance of Point Dose From Non-Gated Radiotherapy Delivery

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, S; Zhu, X; Zhang, M; Zheng, D; Zhang, Q; Lei, Y; Li, S; Driewer, J; Wang, S; Enke, C [University of Nebraska Medical Center, Omaha, NE (United States)

    2015-06-15

    Purpose: Randomness in patient internal organ motion phase at the beginning of non-gated radiotherapy delivery may introduce uncertainty to dose received by the patient. Concerns of this dose deviation from the planned one has motivated many researchers to study this phenomenon although unified theoretical framework for computing it is still missing. This study was conducted to develop such framework for analyzing the effect. Methods: Two reasonable assumptions were made: a) patient internal organ motion is stationary and periodic; b) no special arrangement is made to start a non -gated radiotherapy delivery at any specific phase of patient internal organ motion. A statistical ensemble was formed consisting of patient’s non-gated radiotherapy deliveries at all equally possible initial organ motion phases. To characterize the patient received dose, statistical ensemble average method is employed to derive formulae for two variables: expected value and variance of dose received by a patient internal point from a non-gated radiotherapy delivery. Fourier Series was utilized to facilitate our analysis. Results: According to our formulae, the two variables can be computed from non-gated radiotherapy generated dose rate time sequences at the point’s corresponding locations on fixed phase 3D CT images sampled evenly in time over one patient internal organ motion period. The expected value of point dose is simply the average of the doses to the point’s corresponding locations on the fixed phase CT images. The variance can be determined by time integration in terms of Fourier Series coefficients of the dose rate time sequences on the same fixed phase 3D CT images. Conclusion: Given a non-gated radiotherapy delivery plan and patient’s 4D CT study, our novel approach can predict the expected value and variance of patient radiation dose. We expect it to play a significant role in determining both quality and robustness of patient non-gated radiotherapy plan.

  16. Environmental tipping points in random dynamical systems: a quasigeostrophic case study

    Science.gov (United States)

    Pierini, S.

    2012-04-01

    Environmental tipping points (TPs) leading to abrupt state changes are usually considered in an autonomous dynamical systems framework, in which case early warnings may be identified in signals with increased autocorrelation and variance. An essential step toward a more realistic description of abrupt transitions in the environment and climate is to analyze TPs in random dynamical systems. In this context, a case study based on an operational definition of stochastic TPs and on a nonlinear low-order quasigeostrophic model is presented (Pierini, Phys. Rev. E, 2012). Let us suppose that in an autonomous dynamical system (DS), self-sustained relaxation oscillations emerge if (and only if) a control parameter Q is such that Q > Qo: Qo is therefore a (deterministic) TP. The same system perturbed by noise is said to be "excitable" if a range Q excitable random DS (a case likely to be quite common in environmental and climate dynamics) a stochastic TP is defined here as the random variable Ro whose realizations satisfy the same conditions required for Qo in the deterministic case. The low-order model (with four degrees of freedom) used in this study describes an excitable DS driven by a stationary forcing with amplitude Q (the deterministic control parameter) plus a colored noise characterized by its amplitude A and autocorrelation time scale Ta. A 10-member ensemble is constructed by performing forward time integrations of length T, and by letting A and Ta vary within a broad parametric range. The ensemble averages and (where the random variable N is the number of relaxation oscillations emerging in T) are then computed. The results suggest that in an excitable random DS coherence resonance may be the predominant transition mechanism, in which case stochastic TPs should be considered instead of their classical deterministic counterpart. Possible early warning signals (different from those of the deterministic case) are investigated: a preliminary analysis shows a variety

  17. Human beings' adaptability to extreme environmental changes from medical and physical points of view

    Science.gov (United States)

    Khabarova, Olga; Ragulskaya, Maria; Dimitrova, Svetla; Safaraly-Oghlu Babayev, Elchin; Samsonov, Sergey; Med. Dimitry Markov, Of; Nazarova, Of Med. Olga N.; Rudenchik, Evgeny

    The question about features of human reaction on the sharp environmental physical activity (EPA) changes is considered by international group of physicists and physicians on the base of results of monitoring of human health state in different cities spread on latitude and longitude. The typical reaction of human body on the influences, exceeding the organisms' ability to adaptation, is of stress-reaction character. From medical point of view there is no significant difference for human body -what external (EPA) agent shocked an organism (emotional or some physical threats). First attempt of the organism to restore its homeostasis is stress-reaction, being universal for many stress-factors. Its main stages (such as alarm, resistance, and exhaustion) are detectable by different medical equipments, but we tried to find universal, non-traumatic method of daily measurements, enough sensitive and appropriate for observation of people reaction both on weather and space weather (geomagnetic activity) changes. The experiment was based on a method of electrical conductivity measurements of biologically active (acupunctural) points of human skin. The used method (electroacupunctural method by Dr. R.Voll) is very sensitive to current state of an organism and characterize the functional condition of different organs and systems of human body and allows to express so-called "group's health status" in the units, suitable for comparison with meteorological and heliogeophysical parameters. We conduct the parallel investigations as a part of collaborative study in different geographic latitudes-longitudes (Baku:40° 23'43"N -49° 52'56"E, Troitsk (Moscow region): 55° 28'40"N -37° 18'42"E, Yakutsk: 62° 02'00"N -129° 44'00"E). Measurements were carried out on daily basis with permanent group of functionally healthy persons (Moscow -19, Yakutsk -22, CityBaku -12 volunteers). Daily monitoring of nervous, endocrinological, lymphatic systems, blood, lungs, thick and thin intestine

  18. Control of cheese quality – strategies and methods for delivery of consistent sensory product quality at the point of consumption

    OpenAIRE

    Kraggerud, Hilde

    2011-01-01

    An effective approach to quality control is an important issue for a food producer, as consumers expect consistent delivery of products. Two important strategies for control of food product end quality was discussed in this thesis: Process regulation and Statistical Process control (SPC). Extensive experiments were carried out in order to demonstrate different aspects of control of cheese quality. The sensory quality of a product is of great importance, as it is directly perceived at consu...

  19. 78 FR 4164 - Draft Environmental Impact Statement for the Proposed Point Molate Resort and Casino for the...

    Science.gov (United States)

    2013-01-18

    ... the Federal Register on March 11, 2005 (70 FR 12229-12230). A public scoping meeting was held on March... the Federal Register on July 10, 2009 (74 FR 33236). A Final EIS for this project was not filed with... Bureau of Indian Affairs Draft Environmental Impact Statement for the Proposed Point Molate Resort...

  20. 76 FR 59423 - Drakes Bay Oyster Company Special-Use Permit, Draft Environmental Impact Statement, Point Reyes...

    Science.gov (United States)

    2011-09-26

    ... National Park Service Drakes Bay Oyster Company Special-Use Permit, Draft Environmental Impact Statement... statement to consider the Drakes Bay Oyster Company Special-use permit in Drakes Estero, Point Reyes... National Seashore Web site, at http://parkplanning.nps.gov/pore (click on the Drakes Bay Oyster...

  1. [Melanoma: surface markers as the first point of targeted delivery of therapeutic genes in multilevel gene therapy].

    Science.gov (United States)

    Pleshkan, V V; Zinov'eva, M V; Sverdlov, E D

    2011-01-01

    Melanoma is one of the most malignant tumors, aggressively metastasizing by lymphatic and hematogenous routes. Due to the resistance of melanoma cells to many types of chemotherapy, this disease causes high mortality rate. High hopes are pinned on gene therapeutic approaches to melanoma treatment. At present, one of the main problems of the efficient use of the post-genomic generation therapeutic means is the lack of optimal techniques of delivery of foreign genetic material to the patient's target cells. Surface specific markers of melanoma cells can be considered as promising therapeutic targets. This review describes currently known melanoma specific receptors and its stem cells, as well as contains data on melanoma antigens presented on the cell surface by major histocompatibility complex proteins. The ability of surface proteins to internalize might be successfully used for the development of methods of targeted delivery of gene therapeutic constructs. In conclusion, a concept of multilevel gene therapy and the possible role therein of surface determinants as targets of gene systems delivery to the tumor are discussed.

  2. Evolutionary tipping points in the capacity to adapt to environmental change

    NARCIS (Netherlands)

    Botero, Carlos A.; Weissing, Franz J.; Wright, Jonathan; Rubenstein, Dustin R.

    2015-01-01

    In an era of rapid climate change, there is a pressing need to understand how organisms will cope with faster and less predictable variation in environmental conditions. Here we develop a unifying model that predicts evolutionary responses to environmentally driven fluctuating selection and use this

  3. Evolutionary tipping points in the capacity to adapt to environmental change

    NARCIS (Netherlands)

    Botero, Carlos A.; Weissing, Franz J.; Wright, Jonathan; Rubenstein, Dustin R.

    2015-01-01

    In an era of rapid climate change, there is a pressing need to understand how organisms will cope with faster and less predictable variation in environmental conditions. Here we develop a unifying model that predicts evolutionary responses to environmentally driven fluctuating selection and use this

  4. ESI-HI80 Makaha Point, Island of Kauai, Hawaii 2001 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  5. ESI-HI18 Kauluoa Point, Island of Hawaii, Hawaii 2001 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  6. ESI-HI18 Kauluoa Point, Island of Hawaii, Hawaii 2001 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  7. ESI-HI09 Naliikakani Point, Island of Hawaii, Hawaii 2001 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  8. ESI-HI22 Keahole Point, Island of Hawaii, Hawaii 2001 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  9. The Oil Point Method - A tool for indicative environmental evaluation in material and process selection

    DEFF Research Database (Denmark)

    Bey, Niki

    2000-01-01

    , transport, use to final disposal. Therefore, efforts focus on attempts to integrate environmental aspects into the whole process of product development and design. They often involve established tools and methods for environmental evaluation, such as formal Life Cycle Assessment (LCA). These tools...... are made, such as the decision upon materials and manufacturing processes. It is, therefore, a major challenge to develop tools and methods, which support the environmentally conscious selection of materials and processes while requiring only relatively little time and knowledge in the field...... methods for environmental evaluation: A formal LCA method and another indicator-based method. A set of data for applying the method is presented including over 70 materials in pure or semi-finished form, over 20 manufacturing processes and some 20 other life cycle processes. Other contributions...

  10. ESI-HI80 Makaha Point, Island of Kauai, Hawaii 2001 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  11. ESI-HI56 ILio Point, Island of Molokai, Hawaii 2001 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  12. ESI-HI09 Naliikakani Point, Island of Hawaii, Hawaii 2001 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  13. ENVIRONMENTALISM AND SUSTAINABLE DEVELOPMENT FROM THE POINT OF VIEW OF TOURISM

    OpenAIRE

    Baros, Zoltan; Dávid, Lorant Denes

    2007-01-01

    As a consequence of the rapid growth of the tourism sector, special emphasis is placed on destinations and tourism products connected to or based on certain physical and environmental factors. However, the negative environmental consequences of tourism are, in many cases, overemphasised to the social and/or economic elements of sustainable development. Thus, it is important to find an adequate balance of the elements mentioned above within tourism development in order to achieve an optimal wa...

  14. Maximum power point tracking algorithm based on sliding mode and fuzzy logic for photovoltaic sources under variable environmental conditions

    Science.gov (United States)

    Atik, L.; Petit, P.; Sawicki, J. P.; Ternifi, Z. T.; Bachir, G.; Della, M.; Aillerie, M.

    2017-02-01

    Solar panels have a nonlinear voltage-current characteristic, with a distinct maximum power point (MPP), which depends on the environmental factors, such as temperature and irradiation. In order to continuously harvest maximum power from the solar panels, they have to operate at their MPP despite the inevitable changes in the environment. Various methods for maximum power point tracking (MPPT) were developed and finally implemented in solar power electronic controllers to increase the efficiency in the electricity production originate from renewables. In this paper we compare using Matlab tools Simulink, two different MPP tracking methods, which are, fuzzy logic control (FL) and sliding mode control (SMC), considering their efficiency in solar energy production.

  15. Up to what point is loss reduction environmentally friendly?: The LCA of loss reduction scenarios in drinking water networks.

    Science.gov (United States)

    Pillot, Julie; Catel, Laureline; Renaud, Eddy; Augeard, Bénédicte; Roux, Philippe

    2016-11-01

    In a context of increasing water shortage all over the world, water utilities must minimise losses in their distribution networks and draw up water loss reduction action plans. While leak reduction is clearly an important part of sustainable water management, its impacts have to be reconsidered in a broader objective of environmental protection than strictly the avoided losses in cubic metres of water. Reducing the volume of water abstracted reduces also environmental impacts associated to water production (the operation and infrastructure needed for abstraction, treatment, supply). In the mean time, activities for reducing water losses generate their own environmental impacts, notably as a result of the work, equipment, and infrastructures used for this purpose. In this study, Life Cycle Assessment (LCA) was used to assess and compare two sets of environmental impacts: those resulting from the production and supply of water which will never reach subscribers, and those caused by water loss reduction activities. This information can then be used to establish whether or not there is a point beyond which loss reduction is no longer effective in reducing the environmental impacts of drinking water supply. Results show that the improvement actions that start from a low water supply efficiency are clearly beneficial for ecosystems, human health and preservation of resources. When seeking to improve the efficiency beyond certain values (about 65%), the uncertainty makes it impossible to conclude for an environmental benefit on all impact categories.

  16. 77 FR 4989 - Turning Point Solar LLC: Notice of Availability of an Environmental Assessment

    Science.gov (United States)

    2012-02-01

    ... photovoltaic panels mounted on fixed solar racking equipment and the construction of access roads, a powerhouse...) ground- mounted solar photovoltaic generating facility in Noble County, Ohio. Turning Point Solar LLC...

  17. Aleutian Islands Coastal Resources Inventory and Environmental Sensitivity Maps: VOLCANOS (Volcano Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains point locations of active volcanoes as compiled by Motyka et al., 1993. Eighty-nine volcanoes with eruptive phases in the Quaternary are...

  18. Aleutian Islands Coastal Resources Inventory and Environmental Sensitivity Maps: GEO (Geothermal Activity Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains point locations of geothermally active areas as compiled by Motyka et al., 1993. Because of the variety of geothermal activity present at any...

  19. Aleutian Islands Coastal Resources Inventory and Environmental Sensitivity Maps: M_MAMPT (Marine Mammal Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains biological resource data for seals and sea lions in the Aleutian Islands, Alaska. Points in this data set represent locations of haulout and...

  20. TECHNOLOGY EVALUATION REPORT CEREX ENVIRONMENTAL SERVICES UV HOUND POINT SAMPLE AIR MONITOR

    Science.gov (United States)

    The USEPA's National Homeland Security Research Center (NHSRC) Technology Testing and Evaluation Program (TTEP) is carrying out performance tests on homeland security technologies. Under TTEP, Battelle evaluated the performance of the Cerex UV Hound point sample air monitor in de...

  1. Integration of Environmental Aspects in Tourism Higher Education: the Hotel Managers’ Point of View

    Directory of Open Access Journals (Sweden)

    Gul Gunes

    2012-10-01

    Full Text Available Our environment and our society is continually dynamic. Courses such as hotel management, hygiene, food and beverage, front office are essential for the tourism sector. Besides, concern for environmental issues is one of the key components of higher education for tourism. This study presents a critical review of environmental aspects in higher education for tourism in Turkey. Because the demand for vocational schools (two-year colleges is more than that for faculties, there are more vocational schools than four-year faculties in Turkey. Their curriculum was researched and determined to lessons about the environment. In the scope of this study; a questionnaire was conducted on managers of blue flag hotels to learn their opinion about the sector. According to these reviews, the importance of environmental education in higher education was emphasized.

  2. Toward a Learning Health-care System - Knowledge Delivery at the Point of Care Empowered by Big Data and NLP.

    Science.gov (United States)

    Kaggal, Vinod C; Elayavilli, Ravikumar Komandur; Mehrabi, Saeed; Pankratz, Joshua J; Sohn, Sunghwan; Wang, Yanshan; Li, Dingcheng; Rastegar, Majid Mojarad; Murphy, Sean P; Ross, Jason L; Chaudhry, Rajeev; Buntrock, James D; Liu, Hongfang

    2016-01-01

    The concept of optimizing health care by understanding and generating knowledge from previous evidence, ie, the Learning Health-care System (LHS), has gained momentum and now has national prominence. Meanwhile, the rapid adoption of electronic health records (EHRs) enables the data collection required to form the basis for facilitating LHS. A prerequisite for using EHR data within the LHS is an infrastructure that enables access to EHR data longitudinally for health-care analytics and real time for knowledge delivery. Additionally, significant clinical information is embedded in the free text, making natural language processing (NLP) an essential component in implementing an LHS. Herein, we share our institutional implementation of a big data-empowered clinical NLP infrastructure, which not only enables health-care analytics but also has real-time NLP processing capability. The infrastructure has been utilized for multiple institutional projects including the MayoExpertAdvisor, an individualized care recommendation solution for clinical care. We compared the advantages of big data over two other environments. Big data infrastructure significantly outperformed other infrastructure in terms of computing speed, demonstrating its value in making the LHS a possibility in the near future.

  3. Pharmaceutics, Drug Delivery and Pharmaceutical Technology: A New Test Unit for Disintegration End-Point Determination of Orodispersible Films.

    Science.gov (United States)

    Low, Ariana; Kok, Si Ling; Khong, Yuetmei; Chan, Sui Yung; Gokhale, Rajeev

    2015-11-01

    No standard time or pharmacopoeia disintegration test method for orodispersible films (ODFs) exists. The USP disintegration test for tablets and capsules poses significant challenges for end-point determination when used for ODFs. We tested a newly developed disintegration test unit (DTU) against the USP disintegration test. The DTU is an accessory to the USP disintegration apparatus. It holds the ODF in a horizontal position, allowing top-view of the ODF during testing. A Gauge R&R study was conducted to assign relative contributions of the total variability from the operator, sample or the experimental set-up. Precision was compared using commercial ODF products in different media. Agreement between the two measurement methods was analysed. The DTU showed improved repeatability and reproducibility compared to the USP disintegration system with tighter standard deviations regardless of operator or medium. There is good agreement between the two methods, with the USP disintegration test giving generally longer disintegration times possibly due to difficulty in end-point determination. The DTU provided clear end-point determination and is suitable for quality control of ODFs during product developmental stage or manufacturing. This may facilitate the development of a standardized methodology for disintegration time determination of ODFs. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3893-3903, 2015.

  4. Draft Detailed Project Report and Environmental Assessment, Sandy Point Navigation Channel, Whatcom County, Washington.

    Science.gov (United States)

    1984-11-01

    ment. Maurice L. Schwartz, of Coastal Consultants, Inc., provided a report on shoaling at Sandy Point which was also used in developing this...8217 BS SOFT TO VERY A. SFT. LACO [...j L RAVEL C0%TACT SUR- TORVAYAE.BOOPSF FIT ORGANIC SILT £PEAT IN LAYE RS, VERY CT LL:RA BLACK * ~~ VE ASN PL 44...Schwartz, Maurice L. 1983. Marina inlet shoaling at Sandy Point, Washington. Submitted to Seattle District, U.S. Amy Corps of Engineers. U.S. Fish and

  5. 77 FR 23740 - Sears Point Wetland and Watershed Restoration Project, Sonoma County, CA; Final Environmental...

    Science.gov (United States)

    2012-04-20

    ... restore 955 acres of tidal marsh; preserve and enhance a 106-acre area of non-tidal seasonal wetland while... Fish and Wildlife Service Sears Point Wetland and Watershed Restoration Project, Sonoma County, CA... Wetland and Watershed Restoration Project is now available. The final EIR/EIS, which we prepared and...

  6. Environmental Risk Factors in Psoriasis: The Point of View of the Nutritionist

    Directory of Open Access Journals (Sweden)

    Luigi Barrea

    2016-07-01

    Full Text Available Psoriasis is a common, chronic, immune-mediated skin disease with systemic pro-inflammatory activation, where both environmental and genetic factors contribute to its pathogenesis. Among the risk factors for psoriasis, evidence is accumulating that nutrition plays a major role, per se, in psoriasis pathogenesis. In particular, body weight, nutrition, and diet may exacerbate the clinical manifestations, or even trigger the disease. Understanding the epidemiological relationship between obesity and psoriasis is also important for delineating the risk profile for the obesity-related comorbidities commonly found among psoriatic patients. Moreover, obesity can affect both drug’s pharmacokinetics and pharmacodynamics. Additionally, the overall beneficial effects on the obesity-associated comorbidities, clinical recommendations to reduce weight and to adopt a healthy lifestyle could improve the psoriasis severity, particularly in those patients with moderate to severe disease, thus exerting additional therapeutic effects in the conventional treatment in obese patients with psoriasis. Education regarding modifiable environmental factors is essential in the treatment of this disease and represents one of the primary interventions that can affect the prognosis of patients with psoriasis. The goal is to make psoriatic patients and health care providers aware of beneficial dietary interventions. The aim of this review is to assess the relevance of the environmental factors as modifiable risk factors in psoriasis pathogenesis, with particular regard to the involvement of obesity and nutrition in the management of psoriasis, providing also specific nutrition recommendations.

  7. Environmental Risk Factors in Psoriasis: The Point of View of the Nutritionist

    Science.gov (United States)

    Barrea, Luigi; Nappi, Francesca; Di Somma, Carolina; Savanelli, Maria Cristina; Falco, Andrea; Balato, Anna; Balato, Nicola; Savastano, Silvia

    2016-01-01

    Psoriasis is a common, chronic, immune-mediated skin disease with systemic pro-inflammatory activation, where both environmental and genetic factors contribute to its pathogenesis. Among the risk factors for psoriasis, evidence is accumulating that nutrition plays a major role, per se, in psoriasis pathogenesis. In particular, body weight, nutrition, and diet may exacerbate the clinical manifestations, or even trigger the disease. Understanding the epidemiological relationship between obesity and psoriasis is also important for delineating the risk profile for the obesity-related comorbidities commonly found among psoriatic patients. Moreover, obesity can affect both drug’s pharmacokinetics and pharmacodynamics. Additionally, the overall beneficial effects on the obesity-associated comorbidities, clinical recommendations to reduce weight and to adopt a healthy lifestyle could improve the psoriasis severity, particularly in those patients with moderate to severe disease, thus exerting additional therapeutic effects in the conventional treatment in obese patients with psoriasis. Education regarding modifiable environmental factors is essential in the treatment of this disease and represents one of the primary interventions that can affect the prognosis of patients with psoriasis. The goal is to make psoriatic patients and health care providers aware of beneficial dietary interventions. The aim of this review is to assess the relevance of the environmental factors as modifiable risk factors in psoriasis pathogenesis, with particular regard to the involvement of obesity and nutrition in the management of psoriasis, providing also specific nutrition recommendations. PMID:27455297

  8. A critical evaluation in the delivery of the ultrasound practice: the point of view of the radiologist

    Directory of Open Access Journals (Sweden)

    Giovanni Stasi

    2015-03-01

    Full Text Available The authors describe the benefits and risks of massive and widespread diffusion of ultrasound diagnostics for public and affiliated centers. The main considerations regarding organizational aspects, cultural and qualitative assistance of various medical professionals belonging to the Public Service, unfortunately point out that not all lesions found are able to use the same standardized diagnostic criteria. The risks of errors in diagnostic consumerism, with consequent multiplication of exams, often redundant, are on the rise. The authors urge greater control and the adoption of stricter criteria for the selection of clinical skills of operators who are responsible for this delicate, difficult and at the same time valuable diagnostic task, moreover, of great social value.

  9. Analysis of point source pollution and water environmental quality variation trends in the Nansi Lake basin from 2002 to 2012.

    Science.gov (United States)

    Wang, Weiliang; Liu, Xiaohui; Wang, Yufan; Guo, Xiaochun; Lu, Shaoyong

    2016-03-01

    Based on the data analysis of the water environmental quality and economic development from 2002 to 2012 in the Nansi Lake basin, the correlation and change between the water environmental quality and economic development were studied. Results showed that the GDP and wastewater emissions of point source in the Nansi Lake basin had an average annual growth of 7.30 and 7.68 %, respectively, from 2002 to 2012. The emissions of chemical oxygen demand (COD) and ammonia nitrogen (NH3-N) had the average annual decrease of 7.69 and 6.79 % in 2012, respectively, compared to 2002. Basin water quality overall improved, reaching the Class III of the "Environmental quality standards for surface water (GB3838-2002)," in which the main reason was that sewage treatment rate increased gradually and was above 90 % in 2012 (an increase of 10 % compared to 2002) with the progress of pollution abatement technology and the implementation of relevant policies and regulations. The contribution of water environmental pollution was analyzed from related cities (Ji'ning, Zaozhuang, Heze). Results indicated that Ji'ning had the largest contribution to water pollution of the Nansi Lake basin, and the pollutant from domestic sources accounted for a higher percentage compared to industrial sources. The wastewater, COD, and NH3-N mainly came from mining and washing of coal, manufacture of raw chemical materials and chemical products, papermaking industry, and food processing industry. According to the water pollution characteristics of the Nansi Lake basin, the basin pollution treatment strategy and prevention and treatment system were dissected to provide a scientific basis for prevention and control of lakeside point source pollution along the Nansi Lake.

  10. Trace Level Arsenic Quantification through Cloud Point Extraction: Application to Biological and Environmental Samples

    Directory of Open Access Journals (Sweden)

    Kempahanumakkagari Suresh Kumar

    2012-01-01

    Full Text Available A sensitive solvent-free extraction protocol for the quantification of arsenic at trace level has been described. It is based on the reaction of arsenic (V with molybdate in acidic medium in presence of antimony (III and ascorbic acid as a reducing agent to form a blue-colored arsenomolybdenum blue complex. The complex has been extracted into surfactant phase using Triton X-114, and its absorbance was measured at 690 nm. The detection limit, working range, and the relative standard deviation were found to be 1 ng mL−1, 10–200 ng mL−1, and 1.2%, respectively. The effect of common ions was studied, and the method has been applied to determine trace levels of As(III and As(V from a variety of samples like environmental, biological, and commercially procured chemicals.

  11. The Oil Point Method - A tool for indicative environmental evaluation in material and process selection

    DEFF Research Database (Denmark)

    Bey, Niki

    2000-01-01

    and methods are, however, often relatively complicated and require more time, data and specific expertise in the field than designers usually possess. Furthermore, the detailed information required for an LCA are not available in the early stages of the product development process, where crucial decisions...... are made, such as the decision upon materials and manufacturing processes. It is, therefore, a major challenge to develop tools and methods, which support the environmentally conscious selection of materials and processes while requiring only relatively little time and knowledge in the field......: the method considers exclusively primary energy relationships and it utilises material and process-specific indicators for the calculations. The validation of the method is accomplished by means of five case studies, where results obtained with the OPM are compared to results obtained with two established...

  12. Perfluorooctanoic acid (PFOA) - main concerns and regulatory developments in Europe from an environmental point of view

    Energy Technology Data Exchange (ETDEWEB)

    Vierke, Lena [Federal Environment Agency, Dessau-Rosslau (Germany); Leuphana University of Lueneburg, Lueneburg (Germany); Staude, Claudia; Biegel-Engler, Annegret; Drost, Wiebke; Schulte, Christoph [Federal Environment Agency, Dessau-Rosslau (Germany)

    2012-12-15

    Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) are the most investigated substances of the group of per- and polyfluorinated chemicals (PFCs). Whereas for PFOS regulatory measures are already in force on international level (inclusion in Stockholm Convention on Persistent Organic Pollutants) such activities are missing for PFOA. The environmental concerns of PFOA, which are summarized in the present study, underline the necessity of regulatory measures on an international level for PFOA. Since it seems more likely to agree on a regulation within the European Union first, a regulatory strategy based on the European chemicals regulation REACH (EC No. 1907/2006), is discussed in the present study. PFOA is persistent in the environment, ubiquitous present in surface waters, and subject to long-range transport. It accumulates in biota, especially in top predators. PFOA is increasingly analyzed in food items, and in drinking water. PFOA's intrinsic properties such as its persistency (P), its potential for bioaccumulation (B) and its toxicity (T) suggest that PFOA is a promising candidate for being identified as a Substance of Very High Concern (SVHC) under REACH. Because of the dispersive occurrence of PFOA in the environment, the presence in imported products, and the use of PFCs, which can degrade to PFOA in various consumer products, a restriction under REACH seems to be the most effective regulatory measure to minimize human and environmental exposure to PFOA in the European Union. Due to its intrinsic properties, PFOA fulfills the REACH PBT-criteria. The next regulatory step will be the identification of PFOA and its ammonium salt (APFO) as SVHC according to REACH and the addition to the REACH Candidate List. As a second step, a restriction proposal will be prepared to include both substances and precursors into REACH Annex XVII. (orig.)

  13. Surfactant-mediated cloud point extractions: An environmentally benign alternative separation approach

    Energy Technology Data Exchange (ETDEWEB)

    Quina, F.H.; Hinze, W.L.

    1999-11-01

    Aqueous solutions of certain surfactant micelles exhibit phase separation behavior upon temperature alteration. This phenomenon can be exploited in separation science for the development of extraction, purification, and preconcentration schemes for desired analyses. Since the addition of just a small amount of an appropriate nonionic or zwitterionic surfactant to the aqueous sample solution is required, this approach is convenient and fairly benign, eliminating the need for the use of organic solvents as in conventional liquid-liquid or solid-liquid extraction. The basic features, experimental protocols, and selected recent applications of this alternative extraction approach, termed cloud point extraction (CPE) or micelle-mediated extraction (ME), are briefly reviewed. In addition, the advantages, limitations, and anticipated future directions of this methodology are discussed.

  14. Improvement of logistics education from the point of view environmental management

    Science.gov (United States)

    Bányai, Á.

    2009-04-01

    The paper briefly presents the influence of environmental management on the improvement of the logistics education and research structure of the Department of Materials Handling and Logistics at the University of Miskolc, Hungary. The logistics, as an integrated science offers a very good possibility to demonstrate the effect of new innovative knowledge on the migration of the priorities of education and research of sciences. The importance of logistics in the field of recycling (or in wider sense in the field of environmental management) can be justified by the high proportion of logistic costs (as investment and operation costs) and these costs show that optimum logistic solutions are able to decrease the financial outcomes and lead to the establishment of a profitable system. Technological change constantly creates new demands on both education and research. The most important objective of the department is to create a unique logistics education in the country. For this reason the department offered up-to-date integrated knowledge at all level: undergraduate, master degree and PhD education. The integration of logistics means traditionally the joint use of technology of material handling, method of material flow, technology method of traffic, information technology, management sciences, production technology, marketing, market research, technology of services, mathematics and optimization, communication technology, system engineering, electronics and automation, mechatronics [1, 3]. The education and research portfolio of the department followed this tradition till 1993. The new lectures in the field of sustainability (logistics of recycling, logistics of quality management and recycling, closed loop economy, EU logistics or global logistics) became more and more important in the logistics education. The results of fast developments in closed loop economy, recycling, waste management, environmental protection are more and more used in the industry and this

  15. Random Forest-Based Approach for Maximum Power Point Tracking of Photovoltaic Systems Operating under Actual Environmental Conditions.

    Science.gov (United States)

    Shareef, Hussain; Mutlag, Ammar Hussein; Mohamed, Azah

    2017-01-01

    Many maximum power point tracking (MPPT) algorithms have been developed in recent years to maximize the produced PV energy. These algorithms are not sufficiently robust because of fast-changing environmental conditions, efficiency, accuracy at steady-state value, and dynamics of the tracking algorithm. Thus, this paper proposes a new random forest (RF) model to improve MPPT performance. The RF model has the ability to capture the nonlinear association of patterns between predictors, such as irradiance and temperature, to determine accurate maximum power point. A RF-based tracker is designed for 25 SolarTIFSTF-120P6 PV modules, with the capacity of 3 kW peak using two high-speed sensors. For this purpose, a complete PV system is modeled using 300,000 data samples and simulated using the MATLAB/SIMULINK package. The proposed RF-based MPPT is then tested under actual environmental conditions for 24 days to validate the accuracy and dynamic response. The response of the RF-based MPPT model is also compared with that of the artificial neural network and adaptive neurofuzzy inference system algorithms for further validation. The results show that the proposed MPPT technique gives significant improvement compared with that of other techniques. In addition, the RF model passes the Bland-Altman test, with more than 95 percent acceptability.

  16. Self-entanglement of long linear DNA vectors using transient non-B-DNA attachment points: a new concept for improvement of non-viral therapeutic gene delivery.

    Science.gov (United States)

    Tolmachov, Oleg E

    2012-05-01

    The cell-specific and long-term expression of therapeutic transgenes often requires a full array of native gene control elements including distal enhancers, regulatory introns and chromatin organisation sequences. The delivery of such extended gene expression modules to human cells can be accomplished with non-viral high-molecular-weight DNA vectors, in particular with several classes of linear DNA vectors. All high-molecular-weight DNA vectors are susceptible to damage by shear stress, and while for some of the vectors the harmful impact of shear stress can be minimised through the transformation of the vectors to compact topological configurations by supercoiling and/or knotting, linear DNA vectors with terminal loops or covalently attached terminal proteins cannot be self-compacted in this way. In this case, the only available self-compacting option is self-entangling, which can be defined as the folding of single DNA molecules into a configuration with mutual restriction of molecular motion by the individual segments of bent DNA. A negatively charged phosphate backbone makes DNA self-repulsive, so it is reasonable to assume that a certain number of 'sticky points' dispersed within DNA could facilitate the entangling by bringing DNA segments into proximity and by interfering with the DNA slipping away from the entanglement. I propose that the spontaneous entanglement of vector DNA can be enhanced by the interlacing of the DNA with sites capable of mutual transient attachment through the formation of non-B-DNA forms, such as interacting cruciform structures, inter-segment triplexes, slipped-strand DNA, left-handed duplexes (Z-forms) or G-quadruplexes. It is expected that the non-B-DNA based entanglement of the linear DNA vectors would consist of the initial transient and co-operative non-B-DNA mediated binding events followed by tight self-ensnarement of the vector DNA. Once in the nucleoplasm of the target human cells, the DNA can be disentangled by type II

  17. Hazardous Material Storage Facilities and Sites - WASTE_SEPTAGE_SITES_IDEM_IN: Septage Waste Sites in Indiana (Indiana Department of Environmental Management, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — WASTE_SEPTAGE_SITES_IDEM_IN is a point shapefile that contains septage waste site locations in Indiana, provided by personnel of Indiana Department of Environmental...

  18. Cloud point extraction coupled with HPLC-UV for the determination of phthalate esters in environmental water samples

    Institute of Scientific and Technical Information of China (English)

    WANG Ling; JIANG Gui-bin; CAI Ya-qi; HE Bin; WANG Ya-wei; SHEN Da-zhong

    2007-01-01

    A method based on cloud point extraction was developed to determine phthalate esters including di-ethyl-phthalate (DEP), di-(2-ethylhexyl)-phthalate (DEHP) and di-cyclohexyl- phthalate (DCP) in environmental water samples by high-performance liquid chromatography separation and ultraviolet detection (HPLC-UV). The non-ionic surfactant Triton X-114 was chosen as extraction solvent. The parameters affecting extraction efficiency, such as concentrations of Triton X-114 and Na2SO4, equilibration temperature, equilibration time and centrifugation time were evaluated and optimized. Under the optimum conditions, the method can achieve preconcentration factors of 35, 88, 111 and detection of limits of 2.0, 3.8, 1.0 ng/ml for DEP, DEHP and DCP in 10-ml water sample respectively. The proposed method was successfully applied to the determination of trace amount of phathalate esters in effluent water of the wastewater treatment plant and the lixivium of plastic fragments.

  19. Geospatial simulation: an open-source, model-independent geospatial tool for managing point-based environmental models at multiple spatial locations

    Science.gov (United States)

    Many point-based models have been designed to simulate hydrology, gas flux, nutrient dynamics, and/or plant growth processes at a single point on the landscape. However, these environmental processes are known to be spatially variable. Simulations at different spatial locations therefore require adj...

  20. A model-independent open-source geospatial tool for managing point-based environmental model simulations at multiple spatial locations

    Science.gov (United States)

    Most environmental processes are known to be spatially variable across the landscape. However, many of the simulation models used to estimate and quantify these processes are point-based, meaning they simulate conditions at only one point on the landscape. The objective of this paper is to describ...

  1. Final environmental information volume for the coke oven gas cleaning project at the Bethlehem Steel Corporation Sparrows Point Plant

    Energy Technology Data Exchange (ETDEWEB)

    1990-04-24

    Bethelehem Steel Corporation (BSC) is planning to conduct a demonstration project involving an integrated system that can be retrofitted into coke oven gas handling systems to address a variety of environmental and operational factors in a more cost-effective manner. Successful application of this technology to existing US coke plants could: (1) reduce emissions of sulfur dioxide, cyanide, and volatile organic compounds (including benzene) (2) reduce the cost and handling of processing feed chemicals, (3) disposal costs of nuisance by-products and (4) increase reliability and reduce operation/maintenance requirements for coke oven gas desulfurization systems. The proposed system will remove sulfur from the coke oven gas in the form of hydrogen sulfide using the ammonia indigenous to the gas as the primary reactive chemical. Ammonia and hydrogen cyanide are also removed in this process. The hydrogen sulfide removed from the coke oven gas in routed to a modified Claus plant for conversion to a saleable sulfur by-product. Ammonia and hydrogen cyanide will be catalytically converted to hydrogen, nitrogen, carbon dioxide, and carbon monoxide. The tail gas from the sulfur recovery unit is recycled to the coke oven gas stream, upstream of the new gas cleaning system. The proposed demonstration project will be installed at the existing coke oven facilities at BSC's Sparrows Point Plant. This volume describes the proposed actions and the resulting environmental impacts. 21 refs., 19 figs., 9 tabs.

  2. Local or district heating by natural gas: Which is better from energetic, environmental and economic point of views?

    Energy Technology Data Exchange (ETDEWEB)

    Lazzarin, R.; Noro, M. [Department of Management and Engineering, University of Padova, Stradella S. Nicola, 3-36100 Vicenza (Italy)

    2006-02-01

    Generally, a CHP plant coupled with district heating is considered more efficient than traditional local heating systems from an economic and environmental point of view. This is certainly true for municipal waste CHP plants, but for plants fuelled by natural gas the important developments of the last years regarding both boilers (premixed and modulating burners, condensing boilers, etc.) and mechanical vapour compression and absorption heat pumps can change the traditional view. At the same time also district heating plants improved. Therefore it is worth to analyse the whole matter comparing advantages and disadvantages of the different alternatives, with a wide difference between them. The paper reports on the analysis of major district heating natural gas based technologies (vapour and gas turbines, internal combustion engine, combined cycles); the cost of heat and power produced in these plants is compared to the cost of producing the same quantity of electrical energy by a reference GTCC-Gas Turbine Combined Cycle (actually the most efficient technology for pure electrical production) and the cost of heat production by modern local heating technologies using natural gas as fuel (condensing boilers, electrical, gas engine and absorption heat pumps). Regarding energy efficiency and emissions, modern local heating turns out to be more efficient than district heating for most CHP technologies. However, the same does not happen from an economic point of view, because in Italy natural gas used by cogeneration plants is subjected to a much lower taxation than local heating technologies. (author)

  3. Cloud point extraction of plutonium in environmental matrixes coupled to ICPMS and α spectrometry in highly acidic conditions.

    Science.gov (United States)

    Labrecque, Charles; Whitty-Léveillé, Laurence; Larivière, Dominic

    2013-11-01

    A new cloud point extraction procedure has been developed for the quantification of plutonium(IV) in environmental samples. The separation procedure can be either coupled to inductively coupled plasma mass spectrometry (ICPMS) or α spectrometry for plutonium quantification. The method uses a combination of selective ligand (P,P'-di(2-ethylhexyl) methanediphosphonic acid (H2DEH[MDP])) and micelle shielding by bromine formation to enable quantitative extraction of Pu in highly acidic solutions. Cross-optimization of all parameters (nonionic and ionic surfactant, chelating agent, bromate, bromide, and pH) led to optimal of the extraction conditions. Figures of merit of the method for the detection using α spectrometry and ICPMS are reported (limit of detection, limit of quantification, minimal detectable activity, and recovery). Quantitative extractions (>95%) were obtained for a wide variety of aqueous and digested samples (synthetic urine, wastewater, drinking water, seawater, and soil samples). The method features the first successful coupling between α spectrometry and cloud point extraction and is the first demonstration of CPE suitability with metaborate fusion as a sample preparation approach, techniques used extensively in nuclear industries.

  4. 77 FR 68807 - Notice of Intent To Prepare an Environmental Impact Statement (EIS) for the Halletts Point...

    Science.gov (United States)

    2012-11-16

    ... URBAN DEVELOPMENT Notice of Intent To Prepare an Environmental Impact Statement (EIS) for the Halletts... Environmental Quality Review Act (SEQRA), 6 NYCRR 617, intend to prepare a Draft Environmental Impact Statement... the U.S. Housing Act of 1937. This notice is in accordance with the Council on Environmental...

  5. The relevance of large scale environmental research infrastructures from the point of view of Ethics: the case of EMSO

    Science.gov (United States)

    Favali, Paolo; Beranzoli, Laura; Best, Mairi; Franceschini, PierLuigi; Materia, Paola; Peppoloni, Silvia; Picard, John

    2014-05-01

    instability and failure; • connecting scientific outcomes to stakeholders and policy makers, including to government decision-makers. The development of a large research infrastructure initiatives like EMSO must continuously take into account wide-reaching environmental and socio-economic implications and objectives. For this reason, an Ethics Commitee was established early in EMSO's initial Preparatory Phase with responsibility for overseeing the key ethical and social aspects of the project. These include: • promoting inclusive science communication and data dissemination services to civil society according to Open Access principles; • guaranteeing top quality scientific information and data as results of top quality research; • promoting the increased adoption of eco-friendly, sustainable technologies through the dissemination of advanced scientific knowledge and best practices to the private sector and to policy makers; • developing Education Strategies in cooperation with academia and industry aimed at informing and sensitizing the general public on the environmental and socio-economic implications and benefits of large research infrastructure initiatives such as EMSO; • carrying out Excellent Science following strict criteria of research integrity, as expressed in the Montreal Statement (2013); • promoting Geo-ethical awareness and innovation by spurring innovative approaches in the management of environmental aspects of large research projects; • supporting technological Innovation by working closely in support of SMEs; • providing a constant, qualified and authoritative one-stop-shopping Reference Point and Advisory for politicians and decision-makers. The paper shows how Geoethics is an essential tool for guiding methodological and operational choices, and management of an European project with great impact on the environment and society.

  6. Use of cloud-point preconcentration for spectrophotometric determination of trace amounts of antimony in biological and environmental samples.

    Science.gov (United States)

    El-Sharjawy, Abdel-Azeem M; Amin, Alaa S

    2016-01-01

    This work presents a cloud-point extraction process using the micelle-mediated extraction method for simultaneous preconcentration and determination of Sb(III) and Sb(V) species in biological and environmental samples as a prior preconcentration step to their spectrophotometric determination. The analytical system is based on the selective reaction between Sb(III) and 3-dichloro-6-(3-carboxy-2-hydroxy-1-naphthylazo)quinoxaline (DCHNAQ) in the presence of cetyltrimethylammonium bromide (CTAB) and potassium iodide at pH 4.5. Total Sb concentration was determined after reduction of Sb(V) to Sb(III) in the presence of potassium iodide and ascorbic acid. The optimal reaction conditions and extraction were studied, and the analytical characteristics of the method (e.g., limits of detection and quantification, linear range, preconcentration, improvement factors) were obtained. Linearity for Sb(III) was obeyed in the range of 0.2-20 ng ml(-1). The detection and quantification limits for the determination of Sb(III) were 0.055 and 0.185 ng ml(-1), respectively. The method has a lower detection limit and wider linear range, inexpensive instrument, and low cost, and is more sensitive compared with most other methods. The interference effect of some anions and cations was also studied. The method was applied to the determination of Sb(III) in the presence of Sb(V) and total antimony in blood plasma, urine, biological, and water samples.

  7. Cloud point extraction and flame atomic absorption spectrometry combination for copper(II) ion in environmental and biological samples

    Energy Technology Data Exchange (ETDEWEB)

    Shokrollahi, Ardeshir [Chemistry Department, Yasouj University, Yasouj 75914-353 (Iran, Islamic Republic of)], E-mail: ashokrollahi@mail.yu.ac.ir; Ghaedi, Mehrorang [Chemistry Department, Yasouj University, Yasouj 75914-353 (Iran, Islamic Republic of)], E-mail: m_ghaedi@mail.yu.ac.ir; Hossaini, Omid; Khanjari, Narges [Chemistry Department, Yasouj University, Yasouj 75914-353 (Iran, Islamic Republic of); Soylak, Mustafa [Chemistry Department, University of Erciyes, 38039 Kayseri (Turkey)

    2008-12-30

    A cloud point extraction procedure was presented for the preconcentration of copper(II) ion in various samples. After complexation by 4-(phenyl diazenyl) benzene-1,3-diamine (PDBDM) (chrysoidine), copper(II) ions were quantitatively recovered in Triton X-114 after centrifugation. 0.5 ml of methanol acidified with 1.0 mol L{sup -1} HNO{sub 3} was added to the surfactant-rich phase prior to its analysis by flame atomic absorption spectrometry (FAAS). The influence of analytical parameters including ligand, Triton X-114 and HNO{sub 3} concentrations, bath temperature, heating time, centrifuge rate and time were optimized. The effect of the matrix ions on the recovery of copper(II) ions was investigated. The detection limit (3S.D.{sub b}/m, n = 10) of 0.6 ng mL{sup -1} along with preconcentration factor of 30 and enrichment factor of 41.1 with R.S.D. of 1.0% for Cu was achieved. The proposed procedure was applied to the analysis of various environmental and biological samples.

  8. Classification and environmental properties of X-ray selected point-like sources in the XMM-LSS field

    CERN Document Server

    Melnyk, O; Elyiv, A; Salvato, M; Chiappetti, L; Clerc, N; Gandhi, P; Pierre, M; Sadibekova, T; Pospieszalska-Surdej, A; Surdej, J

    2013-01-01

    The XMM-Large Scale Structure survey, covering an area of 11.1 sq. deg., contains more than 6000 X-ray point-like sources detected with XMM-Newton down to a flux of 3x10^-15 erg s^-1 cm^-2 in the [0.5-2] keV band, the vast majority of which have optical (CFHTLS), infrared (SWIRE), near-infrared (UKIDSS) and/or ultraviolet (GALEX) counterparts. We wish to investigate the environmental properties of the different types of the XMM-LSS X-ray sources, defining their environment using the i-band CFHTLS W1 catalog of optical galaxies down to a magnitude limit of 23.5 mag. We have classified 4435 X-ray selected sources on the basis of their spectra, SEDs and X-ray luminosity and estimated their photometric redshifts, having 4-11 band photometry, with an accuracy sigma=0.076 and 22.6% outliers for i=-0.2) are located in more overdense regions with respect to the Soft AGN (HR1.5) within which Soft AGN are embedded appear to evolve more rapidly with respect to the corresponding overdensities around Hard AGN.

  9. Delivery of Forecasted Atmospheric Ozone and Dust for the New Mexico Environmental Public Health Tracking System - An Open Source Geospatial Solution

    Science.gov (United States)

    Hudspeth, W. B.; Sanchez-Silva, R.; Cavner, J. A.

    2010-12-01

    New Mexico's Environmental Public Health Tracking System (EPHTS), funded by the Centers for Disease Control (CDC) Environmental Public Health Tracking Network (EPHTN), aims to improve health awareness and services by linking health effects data with levels and frequency of environmental exposure. As a public health decision-support system, EPHTS systems include: state-of-the-art statistical analysis tools; geospatial visualization tools; data discovery, extraction, and delivery tools; and environmental/public health linkage information. As part of its mandate, EPHTS issues public health advisories and forecasts of environmental conditions that have consequences for human health. Through a NASA-funded partnership between the University of New Mexico and the University of Arizona, NASA Earth Science results are fused into two existing models (the Dust Regional Atmospheric Model (DREAM) and the Community Multiscale Air Quality (CMAQ) model) in order to improve forecasts of atmospheric dust, ozone, and aerosols. The results and products derived from the outputs of these models are made available to an Open Source mapping component of the New Mexico EPHTS. In particular, these products are integrated into a Django content management system using GeoDjango, GeoAlchemy, and other OGC-compliant geospatial libraries written in the Python and C++ programming languages. Capabilities of the resultant mapping system include indicator-based thematic mapping, data delivery, and analytical capabilities. DREAM and CMAQ outputs can be inspected, via REST calls, through temporal and spatial subsetting of the atmospheric concentration data across analytical units employed by the public health community. This paper describes details of the architecture and integration of NASA Earth Science into the EPHTS decision-support system.

  10. Soil redistribution and nutrient delivery in a Mediterranean rain-fed agro-ecosystem with different crops and management: environmental and economic aspects

    Science.gov (United States)

    López-Vicente, Manuel; Álvarez, Sara

    2017-04-01

    Mediterranean agro-ecosystems are characterised by fragmented fields and patched vegetation. This shape governs the spatial patterns of water, soil and nutrient redistribution. Rainfall parameters, human infrastructures, crop management, support practices, and land use changes (set aside crops, land abandonment) control the magnitude of these processes. Under rain-fed water supply conditions, runoff generation and soil water content are two important factors in determining crop yield. Soil erosion and nutrient delivery are two of the factors which limit crop yield and thus, the gross earning of the landowner. In hilly landscapes, farmers usually supply extra soil to fill in the ephemeral gullies, and nutrient replenishment with fertilizers is a common practice. The aim of this study is to evaluate the environmental (runoff yield, soil erosion and nutrient delivery) and economic (replenishment of soil and nutrient losses with new soil and fertilizers) consequences of different conventional and conservative practices (fallow/crop rotation, cover crops, land abandonment, buffer strips) in a Mediterranean rain-fed agro-ecosystem (27 ha) with vineyards, cereal crops, cultivated and abandoned olive orchards, several trails and patches of natural vegetation. The five winter cereal fields (wheat and barley) follow fallow/crop rotation. The four vineyards are devoted to the Garnacha variety: one planted in 2007 with white wine grapes, and three planted in 2008 with red wine grapes. The inter-crop strips are managed with a mixture of plant species as cover crop (CC), including: i) spontaneous vegetation, and ii) plantation of common sainfoin (Onobrychis viciifolia). The maintenance of the CC includes one mowing pass at the end of spring, between May and June. The appearance and development of ephemeral gullies and the deposition of soil at the bottom of the hillslope are two of the main concerns of the landowners. In some places, the accumulation of soil complicates grape

  11. Environmental Monitoring, Water Quality - WATER_QUALITY_STATISTICS_EPA_IN: Water Quality Monitoring and Data Summaries Indiana, Derived from EPA BASINS (United States Environmental Protection Agency, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — WATER_QUALITY_STATISTICS_EPA_IN is a point shapefile developed by the USEPA BASINS 3.0 program and edited by Bernardin, Lochmueller and Associates. Points represent...

  12. Allocation of petroleum feedstock: Baltimore Gas and Electric Company, Sollers Point SNG Plant, Sollers Point, Baltimore County, Maryland. Final environmental impact statement

    Energy Technology Data Exchange (ETDEWEB)

    Liverman, James L.

    1978-04-01

    An allocation of naphtha feedstock up to 2,186,000 barrels per year to Baltimore Gas and Electric Company (BG and E) to operate its synthetic natural gas (SNG) facility is being considered. The allocation would enable BG and E to produce 10,800,000 mcf of SNG during a 180 day period. Operation of the plant at design capacity is expected to result in annual pollution emissions as follows: 626.4 tons of sulfur oxides, 168.5 tons of nitrogen oxides and 21.6 tons of particulate matter. Incremental emissions due to plant operations relative to existing emissions in Baltimore County are less than 1%. All Federal and State air quality standards should be met. Treated effluent is to be discharged into the Patapasco River where the environmental impacts are not expected to be significant. The SNG facility has been designed to be in compliance with all applicable Federal, State and local effluent standards. Water consumption requirements of 335,000 gallons per day are not expected to significantly tax the area's water resources. Sound generated by the SNG facility will be inaudible or imperceptible. All other operational impacts on land use, population, visual quality, roadways, community facilities and services and ecological systems were judged to be minimal. Environmental impacts resulting from various alternatives ranging from full allocation through denial of an allocation are discussed.

  13. Using in situ simulation to identify and resolve latent environmental threats to patient safety: case study involving a labor and delivery ward.

    Science.gov (United States)

    Hamman, William R; Beaudin-Seiler, Beth M; Beaubien, Jeffrey M; Gullickson, Amy M; Gross, Amy C; Orizondo-Korotko, Krystyna; Fuqua, Wayne; Lammers, Richard

    2009-09-01

    Since the publication of To Err is Human, health care professionals have looked to high-reliability industries such as commercial aviation for guidance on improving system safety. One of the most widely adopted aviation-derived approaches is simulation-based team training, also known as crew resource management (CRM) training. In the health care domain, CRM training often takes place in custom-built simulation laboratories that are designed to replicate operating rooms or labor and delivery rooms. Unlike these traditional CRM training programs, in situ simulation occurs on actual patient care units, involves actual health care team members, and uses actual organization processes to train and assess team performance. During the past 24 months, our research team has conducted nearly 40 in situ simulations. In this paper, we present the results from one such simulation: a patient who experienced a difficult labor and delivery resulting in an emergency caesarean section and a hysterectomy. During the simulation, a number of latent environmental threats to safety were identified. The following article presents not only the latent threats but also the steps that the hospital has taken to remedy them. Results from clinical simulations in operational health care settings can help identify and resolve latent environmental threats to patient safety.

  14. Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group.

    Science.gov (United States)

    Breton, Carrie V; Marsit, Carmen J; Faustman, Elaine; Nadeau, Kari; Goodrich, Jaclyn M; Dolinoy, Dana C; Herbstman, Julie; Holland, Nina; LaSalle, Janine M; Schmidt, Rebecca; Yousefi, Paul; Perera, Frederica; Joubert, Bonnie R; Wiemels, Joseph; Taylor, Michele; Yang, Ivana V; Chen, Rui; Hew, Kinjal M; Freeland, Deborah M Hussey; Miller, Rachel; Murphy, Susan K

    2017-04-01

    Characterization of the epigenome is a primary interest for children's environmental health researchers studying the environmental influences on human populations, particularly those studying the role of pregnancy and early-life exposures on later-in-life health outcomes. Our objective was to consider the state of the science in environmental epigenetics research and to focus on DNA methylation and the collective observations of many studies being conducted within the Children's Environmental Health and Disease Prevention Research Centers, as they relate to the Developmental Origins of Health and Disease (DOHaD) hypothesis. We address the current laboratory and statistical tools available for epigenetic analyses, discuss methods for validation and interpretation of findings, particularly when magnitudes of effect are small, question the functional relevance of findings, and discuss the future for environmental epigenetics research. A common finding in environmental epigenetic studies is the small-magnitude epigenetic effect sizes that result from such exposures. Although it is reasonable and necessary that we question the relevance of such small effects, we present examples in which small effects persist and have been replicated across populations and across time. We encourage a critical discourse on the interpretation of such small changes and further research on their functional relevance for children's health. The dynamic nature of the epigenome will require an emphasis on future longitudinal studies in which the epigenome is profiled over time, over changing environmental exposures, and over generations to better understand the multiple ways in which the epigenome may respond to environmental stimuli.

  15. ESI-VI3 East Point, St. Croix, U.S. Virgin Islands 2000 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  16. ESI-VI3 East Point, St. Croix, U.S. Virgin Islands 2000 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  17. The 2D Hyperlink/Geocaching hybrid as a New Method for Improving Communication and Educational Delivery in Environmental Science

    Science.gov (United States)

    Graham, J.; Byrne, J. M.

    2009-12-01

    Geocaching is a game of hiding and locating caches (treasures), usually with the aid of a GPS-enabled device, and then posting the locations online for others to discover. Its remarkable success as a cultural phenomenon - transcending the traditional boundaries of age, gender, race and culture, while seamlessly combining the elements of technology, mental challenge, travel, geography, orienteering and entertainment - has been well documented. One would expect, therefore, that something so accessible and so physically, mentally and technologically engaging could also have great potential as an educational tool; specifically for the teaching of environmental science in situ. The attempts to date, however, have been disappointing. It will be the purpose of this poster to demonstrate a new and effective approach to educational environmental science-based geocaching; one which treats discreet elements of the living landscape as caches (rather than obstacles), and which combines several commonly available technologies so as to create a rich, immersive experience for viewers of many ages and backgrounds. Specifically, our poster will demonstrate how traditional geocaching methods can be dramatically improved, for the purposes of education, by combining it with 2D hyperlinking technologies in such a way as to allow the viewer to access a variety of different online and/or offline media elements - documentaries, texts, websites, animations, and images, while immersed in the physical environment to which they relate. It will be shown that this site-specific approach to environmental education has considerable potential for improving the meaningful dialogue between environmental scientists and the general public.

  18. Underground Storage Tanks - UST_IDEM_IN: Underground Storage Tanks in Indiana (Indiana Department of Environmental Management, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — UST_IDEM_IN is a point shapefile that contains regulated underground storage tank locations (including leaking underground storage tanks) in Indiana, provided by...

  19. Comparing the Effect of Acupressure at Two GB-21 and SP-6 Points on the Pain Severity of Active Phase of Delivery among Primiparous Women

    Directory of Open Access Journals (Sweden)

    M Akbarzadeh

    2012-02-01

    Full Text Available Background & Aim: Skeletal muscle contraction, secondary to pain and fear, may cause a reaction in the pelvic floor muscle contraction and may result in atypical labor progress, fetal descent and rotation of head. The object of this study was to compare the effect of acupressure at two GB-21 and SP-6 points on the severity of labor pain. Methods: In this quasi-experimental study, 150 primiparous women were randomly divided into three groups of 1-Acupressure at GB-21 point, 2-Acupressure at SP-6 point and 3-control group (contact at two points. The intervention was carried out for 20 minutes at 3-4 cm dilatation of cervix. The pain severity prior to, immediately and 3 and 60 minutes after intervention were measured by Visual Analog Scale. Collected data were analysed using repeated measures analysis of variances. Results: The pain severity before intervention among three groups was not statistically significant. Nevertheless, the pain severity was reduced immediately, 30 and 60 minutes after intervention in two intervention groups at 3-4 cm dilatation as compared with the control group (P<0.001. No significant statistical difference was observed between the two case groups (P=0.93. Conclusion: Current study showed that the application of acupressure at two GB-21 and SP-6 points was effective on the reduction of the severity of labor pain. Hence, it is recommended to conduct further studies regarding the application of acupressure along with non-medicinal methods.

  20. Real-Time Delivery of Global Environmental Observation Data From Space-Based Sensors using the Inmarsat BGAN System

    Science.gov (United States)

    McCormick, C. C.; Lenz, C.; Yunck, T.

    2010-12-01

    This presentation describes a technique and the resulting improvements in quality and latency related to the collection, processing, and distribution of environmental observation data that is collected globally, from space-based sensors. The technique employs a newly developed transceiver which allows a spacecraft in low-earth orbit to communicate with the ground in real-time, globally, via the existing constellation of Inmarsat commercial communication satellites. The ability to communicate with the space-based platform and its sensors at all times, with data latencies measured in milliseconds rather than tens of minutes opens up new opportunities for the collection and application of data captured by sensors in space, as well as the ability for closed-loop tasking of the space based instruments or uploading large data sets to the instruments. The authors describe the technology involved, followed by the description of how this technology is being applied for the real-time collection of space weather observations. The process of collection, data transfer, processing, and distribution is described, highlighting the areas where this new technology improves value of the collected data with the reduced latency. Finally, the paper provides a glance at other applications and data products where this technology and approach could be employed to improve data value and to develop new applications of data collected on space-based platforms.

  1. Estimating the cost of cholera-vaccine delivery from the societal point of view: A case of introduction of cholera vaccine in Bangladesh.

    Science.gov (United States)

    Sarker, Abdur Razzaque; Islam, Ziaul; Khan, Iqbal Ansary; Saha, Amit; Chowdhury, Fahima; Khan, Ashraful Islam; Cravioto, Alejandro; Clemens, John David; Qadri, Firdausi; Khan, Jahangir A M

    2015-09-11

    Cholera is a major global public health problem that causes both epidemic and endemic disease. The World Health Organization recommends oral cholera vaccines as a public health tool in addition to traditional prevention practices and treatments in both epidemic and endemic settings. In many developing countries like Bangladesh, the major issue concerns the affordability of this vaccine. In February 2011, a feasibility study entitled, "Introduction of Cholera Vaccine in Bangladesh (ICVB)", was conducted for a vaccination campaign using inactivated whole-cell cholera vaccine (Shanchol) in a high risk area of Mirpur, Dhaka. Empirical data obtained from this trial was used to determine the vaccination cost for a fully immunized person from the societal perspective. A total of 123,661 people were fully vaccinated receiving two doses of the vaccine, while 18,178 people received one dose of the same vaccine. The total cost for vaccine delivery was US$ 492,238 giving a total vaccination cost per fully-vaccinated individual of US$ 3.98. The purchase cost of the vaccine accounted for 58% of the overall cost of vaccination. Attempts to reduce the per-dose cost of the vaccine are likely to have a large impact on the cost of similar vaccination campaigns in the future. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Toward a Learning Health-care System – Knowledge Delivery at the Point of Care Empowered by Big Data and NLP

    Science.gov (United States)

    Kaggal, Vinod C.; Elayavilli, Ravikumar Komandur; Mehrabi, Saeed; Pankratz, Joshua J.; Sohn, Sunghwan; Wang, Yanshan; Li, Dingcheng; Rastegar, Majid Mojarad; Murphy, Sean P.; Ross, Jason L.; Chaudhry, Rajeev; Buntrock, James D.; Liu, Hongfang

    2016-01-01

    The concept of optimizing health care by understanding and generating knowledge from previous evidence, ie, the Learning Health-care System (LHS), has gained momentum and now has national prominence. Meanwhile, the rapid adoption of electronic health records (EHRs) enables the data collection required to form the basis for facilitating LHS. A prerequisite for using EHR data within the LHS is an infrastructure that enables access to EHR data longitudinally for health-care analytics and real time for knowledge delivery. Additionally, significant clinical information is embedded in the free text, making natural language processing (NLP) an essential component in implementing an LHS. Herein, we share our institutional implementation of a big data-empowered clinical NLP infrastructure, which not only enables health-care analytics but also has real-time NLP processing capability. The infrastructure has been utilized for multiple institutional projects including the MayoExpertAdvisor, an individualized care recommendation solution for clinical care. We compared the advantages of big data over two other environments. Big data infrastructure significantly outperformed other infrastructure in terms of computing speed, demonstrating its value in making the LHS a possibility in the near future. PMID:27385912

  3. Cloud point extraction for the determination of copper, nickel and cobalt ions in environmental samples by flame atomic absorption spectrometry.

    Science.gov (United States)

    Ghaedi, M; Shokrollahi, A; Ahmadi, F; Rajabi, H R; Soylak, M

    2008-02-11

    A cloud point extraction procedure was presented for the preconcentration of copper, nickel and cobalt ions in various samples. After complexation with methyl-2-pyridylketone oxime (MPKO) in basic medium, analyte ions are quantitatively extracted to the phase rich in Triton X-114 following centrifugation. 1.0 mol L(-1) HNO(3) nitric acid in methanol was added to the surfactant-rich phase prior to its analysis by flame atomic absorption spectrometry (FAAS). The adopted concentrations for MPKO, Triton X-114 and HNO(3), bath temperature, centrifuge rate and time were optimized. Detection limits (3 SDb/m) of 1.6, 2.1 and 1.9 ng mL(-1) for Cu(2+), Co(2+) and Ni(2+) along with preconcentration factors of 30 and for these ions and enrichment factor of 65, 58 and 67 for Cu(2+), Ni(2+) and Co(2+), respectively. The high efficiency of cloud point extraction to carry out the determination of analytes in complex matrices was demonstrated. The proposed procedure was applied to the analysis of biological, natural and wastewater, soil and blood samples.

  4. Cloud point extraction for the determination of copper, nickel and cobalt ions in environmental samples by flame atomic absorption spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Ghaedi, M. [Chemistry Department, University of Yasouj, Yasouj 75914-353 (Iran, Islamic Republic of)], E-mail: m_ghaedi@mail.yu.ac.ir; Shokrollahi, A.; Ahmadi, F.; Rajabi, H.R. [Chemistry Department, University of Yasouj, Yasouj 75914-353 (Iran, Islamic Republic of); Soylak, M. [Chemistry Department, University of Erciyes, 38039 Kayseri (Turkey)

    2008-02-11

    A cloud point extraction procedure was presented for the preconcentration of copper, nickel and cobalt ions in various samples. After complexation with methyl-2-pyridylketone oxime (MPKO) in basic medium, analyte ions are quantitatively extracted to the phase rich in Triton X-114 following centrifugation. 1.0 mol L{sup -1} HNO{sub 3} nitric acid in methanol was added to the surfactant-rich phase prior to its analysis by flame atomic absorption spectrometry (FAAS). The adopted concentrations for MPKO, Triton X-114 and HNO{sub 3}, bath temperature, centrifuge rate and time were optimized. Detection limits (3 SDb/m) of 1.6, 2.1 and 1.9 ng mL{sup -1} for Cu{sup 2+}, Co{sup 2+} and Ni{sup 2+} along with preconcentration factors of 30 and for these ions and enrichment factor of 65, 58 and 67 for Cu{sup 2+}, Ni{sup 2+} and Co{sup 2+}, respectively. The high efficiency of cloud point extraction to carry out the determination of analytes in complex matrices was demonstrated. The proposed procedure was applied to the analysis of biological, natural and wastewater, soil and blood samples.

  5. Perception of hydro-meteorological hazard in Camagüey province: a starting point for environmental education

    Directory of Open Access Journals (Sweden)

    Parrado, O.

    2014-01-01

    Full Text Available The results of the study of the perception of hazard due to floods, intense rains, in-land sea floods and strong winds are presented, according to the methodology proposed by the National Group of Evaluation of Risks that coordinates by the Environment Agency (AMA of the CITMA. The analysis units were the municipalities and the d areas of defense. For the statistical analysis of data the software Excel, SPSS and Data Entry were used. The sample taken includes 1 599 people which represents 0, 20% of the population of the county; 62.3% of the sample belongs to the municipalities of Camagüey, Florida, Nuevitas, Vertientes and Santa Cruz del Sur. The results of surveys, in most of those interviewed (53%, determines that the level of perception of the hazard on the part of the population is mainly medium (perception closed to reality aside from the structural, functional, economic and ecological vulnerabilities. There are differences levels of perception form one Popular Council to another. These differences are discussed according to the studied socio demographics variables and the hints given for the needed environmental education.

  6. Comparing patient and healthcare worker experiences during a dengue outbreak in Singapore: understanding the patient journey and the introduction of a point-of-care test (POCT) toward better care delivery.

    Science.gov (United States)

    Tan, Qinghui; Hildon, Zoe J-L; Singh, Shweta; Jing, Jin; Thein, Tun Linn; Coker, Richard; Vrijhoef, Hubertus J M; Leo, Yee Sin

    2017-07-19

    In the aftermath of an upsurge in the number of dengue cases in 2013 and 2014, the SD BIOLINE Dengue Duo rapid diagnostic Point-of-Care Test (POCT) kit was introduced in Tan Tock Seng Hospital, Singapore in June 2013. It is known that the success of POCT usage is contingent on its implementation within the health system. We evaluated health services delivery and the Dengue Duo rapid diagnostic test kit application in Singapore from healthcare workers' perspectives and patient experiences of dengue at surge times. Focus group discussions were conducted with dengue patients, from before and after the POCT implementation period. In-depth interviews with semi-structured components with healthcare workers were carried out. A patient centred process mapping technique was used for evaluation, which mapped the patient's journey and was mirrored from the healthcare worker's perspective. Patients and healthcare workers confirmed a wide range of symptoms in adults, making it challenging to determine diagnosis. There were multiple routes to help seeking, and no 'typical patient journey', with patients either presenting directly to the hospital emergency department, or being referred there by a primary care provider. Patients groups diagnosed before and after POCT implementation expressed some differences between speed of diagnoses and attitudes of doctors, yet shared negative feelings about waiting times and a lack of communication and poor information delivery. However, the POCT did not in its current implementation do much to help waiting times. Healthcare workers expressed that public perceptions of dengue in recent years was a major factor in changing patient management, and that the POCT kit was helpful in improving the speed and accuracy of diagnoses. Health service delivery for dengue patients in Singapore was overall perceived to be of an acceptable clinical standard, which was enhanced by the introduction of the POCT. However, improvements can be focused on Adapting

  7. Delivery presentations

    Science.gov (United States)

    ... passage will take place depends on how your baby is positioned during delivery. The best position for the baby to be ... possible, but labor will generally take longer. After delivery, the baby's face or brow will be swollen and may ...

  8. A Record of Environmental Change in Caribbean Coral Reefs: Sclerochronology and Geochemistry of O. faveolata as a Paleoclimate Proxy at Coral Gardens and Rocky Point, Belize

    Science.gov (United States)

    DeCorte, I. A.; Greer, L.; Wirth, K. R.; Flowers Falls, E.; Lescinsky, H.; Doss, W. C.

    2015-12-01

    Over the last several decades, Acropora cervicornis has seen a massive die-off in the Caribbean. (Aronson and Precht 2001; Gardner et al., 2003; Greer et al., 2009). The potential causes of decline in A. cervicornis in the Caribbean include: extremes in sea surface temperatures (SST), ocean acidification, eutrophication, white-band disease, storm disturbances, and other anthropogenic disturbances. Contrary to the regional decline in A. cervicornis, Coral Gardens on the Belize Barrier Reef has an Acropora sp. population that appears to be thriving. Through a combination of sclerochronology, stable isotope analysis, and in situ sensor data, this work capitilizes on the opportunity to study reef conditions in a site where micro-environmental conditions appear to be favorable for healthy A. cervicornis coral growth. We use cores from two Orbicella faveolata colonies located within Acropora stands, as A. cervicornis does not reveal annual banding. We compare two cores from one O. faveolata colony at Coral Gardens, first cored in 2011 and again in 2014, to one O. faveolata core at near-by Rocky Point, where A. cervicornis is much less abundant. These cores were x-radiographed in order to expose the annual banding and sampled for stable oxygen and carbon isotope analysis (10-15 samples/cm). We show that, although there are no significant differences in the range of the δ18O and δ13C signature between Rocky Point and Coral Gardens, there is a clear difference in the stress histories at these locations as inferred from linear extension rates (LER's) and annual banding patterns. Rocky Point averages a LER of 10.5±1.4 mm/year (n = 29) over a 30 year record and Coral Gardens averages 9.1±1.2 mm/year (n = 70) from ~1953 - 2001, and averages 6.2±1.6 mm/year (n = 36) from coral years 2001-2014 after an inferred stress-banding event. This is in contrast to the observed overall health of A. cervicornis at the two locations. The inferred stress-banding event is currently

  9. A green analytical procedure for sensitive and selective determination of antimony in environmental and biological samples by ligandless cloud point extraction

    Science.gov (United States)

    Rezaei, Vida; Samadi-Maybodi, Abdolraouf

    2012-09-01

    A very simple, environmental friendly and sensitive method based on the cloud point extraction (CPE) separation and spectrophotometric detection has been developed for the determination of antimony. The method is founded on the color reaction of Sb (III) with iodide in acidic medium and subsequent micelle-mediated extraction of the product using the non-ionic surfactant, Triton X-114, in the absence of any chelating agent. The Effects of reaction and extraction parameters were studied and optimum conditions were established. The calibration graph was linear in the range of 0.80-95 ng mL-1 of antimony in the initial solution with r = 0.9994 (n = 9). Detection limit based on three times the standard deviation of the blank (3Sb) was 0.23 ng mL-1 and the relative standard deviation (R.S.D.) for 10 and 70 ng mL-1 of antimony were 3.32 and 1.85% (n = 8), respectively. The proposed method was compared with other methods and favorably applied to evaluate this metal in some real samples, including seawater, antileishmanial drug (glucantime) and human serum.

  10. On the Relationship between Economic Development, Environmental Integrity and Well-Being: The Point of View of Herdsmen in Northern China Grassland.

    Science.gov (United States)

    Dong, Xiaobin; Dai, Guangshuo; Ulgiati, Sergio; Na, Risu; Zhang, Xinshi; Kang, Muyi; Wang, Xuechao

    2015-01-01

    Inner Mongolia is among the most important regions in terms of contribution to the socio-economic development of China. Furthermore, its grassland is a major ecological barrier for Northern China. The present study evaluates the changes in ecosystem services availability and human wellbeing based on a survey on864 herdsmen of the grassland and 20 governmental officials. The survey provided the following results: (1) The supporting and provisioning services of the grassland have recently declined, thus affecting the herdsmen's wellbeing. The intensity of grazing, coal exploitation and tourism development heavily limits the availability of ecosystem services, among which provisioning ones are perceived as the most important. Below a certain threshold, grazing and mining are likely to promote the improvement of herdsmen's wellbeing, while trespassing that point, the enhancement of the herdsmen's living standards is curbed. (2) The herdsmen's cultural exchange, health conditions and social relations are better now than before; however, the threats on herdsmen's health and safety have increased. (3) A better income is among the most urgent herdsmen's needs. Livestock revenues did not increase at the same rate as the damage to the grassland and human risk exposure did. (4) The governmental ecological compensation policy did not entirely solve the problem of grassland desertification and environmental degradation, although it is also true that the degree of implementation and effectiveness of government policies is related to the still insufficient herdsmen's understanding and acceptance of these policies.

  11. Forceps Delivery

    Science.gov (United States)

    ... in place to control the advance of your baby's head. Forceps deliveries aren't always successful. If your health care ... com. Accessed June 12, 2015. You and your baby: Prenatal care, labor and delivery, and postpartum care. Washington, D.C.: The American ...

  12. 78 FR 15797 - Service Delivery Plan

    Science.gov (United States)

    2013-03-12

    ... ADMINISTRATION Service Delivery Plan AGENCY: Social Security Administration (SSA). ACTION: Notice; request for comments. SUMMARY: We are requesting public input as we finalize our Service Delivery Plan (SDP). We... Nation's economy. Today, the challenge of service delivery is greater than at any other point in...

  13. Evaluation of a cloud point extraction approach for the preconcentration and quantification of trace CuO nanoparticles in environmental waters

    Energy Technology Data Exchange (ETDEWEB)

    Majedi, Seyed Mohammad [Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore); Kelly, Barry C. [Department of Civil and Environmental Engineering, National University of Singapore, 1 Engineering Drive 2, Singapore 117576 (Singapore); Lee, Hian Kee, E-mail: chmleehk@nus.edu.sg [Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore); National University of Singapore Environmental Research Institute, T-Lab Building #02-01, 5A Engineering Drive 1, Singapore 117411 (Singapore)

    2014-03-01

    Highlights: • The robustness of cloud point extraction approach was investigated for the analysis of trace CuO NPs in water. • The behavior and fate, and therefore, the recovery of CuO NPs varied substantially under different extraction conditions. • The effects of environmental factors on the NP behavior and extraction were determined and minimized. • Limits of detection of 0.02 and 0.06 μg L⁻¹ were achieved using ICP-MS and GF-AAS, respectively. • Environmental water samples were successfully pre-treated and analyzed. Abstract: The cloud point extraction (CPE) of commercial copper(II) oxide nanoparticles (CuO NPs, mean diameter of 28 nm) in water samples was fully investigated. Factors such as Triton X-114 (TX-114) concentration, pH, incubation temperature and time, were optimized. The effects of CuO NP behavior like agglomeration, dissolution, and surface adsorption of natural organic matter, Cu²⁺, and coating chemicals, on its recovery were studied. The results indicated that all the CPE factors had significant effects on the extraction efficiency. An enrichment factor of ~89 was obtained under optimum CPE conditions. The hydrodynamic diameter of CuO NPs increased to 4–5 μm upon agglomeration of NP-micelle assemblies, and decreased at pH >10.0 at which the extraction efficiency was also lowered. The solubility and therefore, the loss of NPs were greatly enhanced at pH <8.5 and in the first 60 min of incubation, whereas it declined at elevated incubation temperatures. Our results showed that the dissolved organic carbon (DOC) >5 mg C L⁻¹ and Cu²⁺ >2 times that of CuO NPs, lowered and enhanced the extraction efficiency, respectively. Pre-treatment of samples with 3% w v⁻¹ of hydrogen peroxide and 10 mM of ethylenediaminetetraacetic acid minimized the interferences posed by DOC and Cu²⁺, respectively. The decrease in CPE efficiency was also evident for ligands like poly(ethylene glycol). The TX-114-rich phase could be determined

  14. Global Assessment of Hydrogen Technologies – Tasks 3 & 4 Report Economic, Energy, and Environmental Analysis of Hydrogen Production and Delivery Options in Select Alabama Markets: Preliminary Case Studies

    Energy Technology Data Exchange (ETDEWEB)

    Fouad, Fouad H.; Peters, Robert W.; Sisiopiku, Virginia P.; Sullivan Andrew J.; Gillette, Jerry; Elgowainy, Amgad; Mintz, Marianne

    2007-12-01

    This report documents a set of case studies developed to estimate the cost of producing, storing, delivering, and dispensing hydrogen for light-duty vehicles for several scenarios involving metropolitan areas in Alabama. While the majority of the scenarios focused on centralized hydrogen production and pipeline delivery, alternative delivery modes were also examined. Although Alabama was used as the case study for this analysis, the results provide insights into the unique requirements for deploying hydrogen infrastructure in smaller urban and rural environments that lie outside the DOE’s high priority hydrogen deployment regions. Hydrogen production costs were estimated for three technologies – steam-methane reforming (SMR), coal gasification, and thermochemical water-splitting using advanced nuclear reactors. In all cases examined, SMR has the lowest production cost for the demands associated with metropolitan areas in Alabama. Although other production options may be less costly for larger hydrogen markets, these were not examined within the context of the case studies.

  15. Environmental Performance

    DEFF Research Database (Denmark)

    2017-01-01

    as its starting point to investigate liveness within a specific kind of contemporary performance: ‘environmental performances’. Environmental performances are arts practices that take environmental processes as their focus by framing activities of non-human performers such as clouds, wind and weeds - key...

  16. Impact of climate change on the role of non-governmental organizations in environmental health delivery in south-eastern region of Nigeria

    Directory of Open Access Journals (Sweden)

    Jacinta A. Opara

    2016-04-01

    Full Text Available Climate change remains a serious problem to most rural settlement in Nigeria. Individuals are faced with a wide range of health problems. These problems include high risk of communicable and non-communicable diseases, an outbreak of epidemics, and scarcity of water. This study investigated the impact of climate change on health delivery services by Non-Governmental Organizations (NGOs to the different Local Government Areas (LGA of the five the States in the South -Eastern Region in Nigeria: Anambra, Imo, Abia, Ebonyi and Enugu were selected and three communities from each was sampled using stratified random sampling technique. The result revealed that most NGO health workers could not penetrate into most of the rural areas to deliver aids to the victims

  17. Confined Feeding Operations - CONFINED_FEEDING_OPERATIONS_IDEM_IN: Confined Feeding Operation Facilities in Indiana (Indiana Department of Environmental Management, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — CONFINED_FEEDING_OPERATIONS_IDEM_IN is a point shapefile that contains confined feeding operation facility locations in Indiana, provided by personnel of Indiana...

  18. Sewerage Treatment Plants - WASTE_TREATMENT_STORAGE_DISPOSAL_IDEM_IN: Treatment, Storage, and Disposal Sites in Indiana (Indiana Department of Environmental Management, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — WASTE_TREATMENT_STORAGE_DISPOSAL_IDEM_IN is a point shapefile that contains treatment, storage, and disposal (TSD) site locations in Indiana, provided by personnel...

  19. Landfills, Hazardous Waste - CONSTRUCTION_DEMOLITION_WASTE_IDEM_IN: Construction and Demoliton Waste Facilities in Indiana (Indiana Department of Environmental Management, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — CONSTRUCTION_DEMOLITION_WASTE_IDEM_IN is a point shapefile that contains construction and demolition waste facility locations in Indiana, provided by personnel of...

  20. Hazardous Material Storage Facilities and Sites - WASTE_SOLID_ACTIVE_PERMITTED_IDEM_IN: Active Permitted Solid Waste Sites in Indiana (Indiana Department of Environmental Management, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — WASTE_SOLID_ACTIVE_PERMITTED_IDEM_IN is a point shapefile that contains active permitted solid waste site locations in Indiana, provided by personnel of Indiana...

  1. Superfund and Toxic Release Inventory Sites - SUPERFUND_IDEM_IN: Superfund Program Facilities in Indiana (Indiana Department of Environmental Management, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — SUPERFUND_IDEM_IN is a point shapefile that contains GPS-located Superfund Program facility locations in Indiana, provided by personnel of Indiana Department of...

  2. Sediment Types - SEDIMENT_INVENTORY_EPA_IN: National Sediment Inventory (NSI) and Data Summaries in Indiana, Derived from EPA BASINS 3 (United States Environmental Protection Agency, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — SEDIMENT_INVENTORY_EPA_IN is a point shapefile from the National Sediment Inventory developed by the USEPA BASINS 3.0 program and edited by Bernardin, Lochmueller...

  3. Dam Inventory - DAMS_1996_EPA_IN: Inventory of Dams in Indiana, Derived from EPA BASINS (United States Environmental Protection Agency, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — DAMS_1996_EPA_IN is a point shapefile developed by the USEPA BASINS 3.0 program and clipped by Bernardin, Lochmueller and Associates. Clips were performed using the...

  4. Climate policy conception of the Federal Environmental Agency. Necessary position of points 2009; Konzeption des Umweltbundesamtes zur Klimapolitik. Notwendige Weichenstellungen 2009

    Energy Technology Data Exchange (ETDEWEB)

    Knoche, Guido; Luenenbuerger, Benjamin; Hain, Benno; Mueschen, Klaus

    2009-10-15

    The report on the climate policy concept of the Federal Environmental Agency covers the following issues: Climatic change and the consequences: climatic change until today, future climatic change, consequences in Germany, effects on environment, society and industry. Goals of climate policy: maximum global warming of 2 deg C, reversal of global greenhouse gas emissions until 2020, sustainable development and adaptation strategies. Adaptation: international adaptation, national and regional instruments, adaptation concerning public health, environmental protection, including biodiversity in agriculture and forestry, economics. Reduction of greenhouse gas emissions: international treaty beyond 2013, reduced emissions in industrial and developing countries, national goals, climate protection instruments, reduction within electricity, heat and traffic, reduction of fluorine containing gases in agriculture, economical cost and benefit considerations, effects on economic growth and employment. Synergies and conflicts between climate policy and other environmental goals: climate protection, public health and ecosystems, biomass conversion and sustainable agriculture, climate and resources protection, development of a sustainable energy supply.

  5. Bioresponsive matrices in drug delivery

    Directory of Open Access Journals (Sweden)

    Ye George JC

    2010-11-01

    Full Text Available Abstract For years, the field of drug delivery has focused on (1 controlling the release of a therapeutic and (2 targeting the therapeutic to a specific cell type. These research endeavors have concentrated mainly on the development of new degradable polymers and molecule-labeled drug delivery vehicles. Recent interest in biomaterials that respond to their environment have opened new methods to trigger the release of drugs and localize the therapeutic within a particular site. These novel biomaterials, usually termed "smart" or "intelligent", are able to deliver a therapeutic agent based on either environmental cues or a remote stimulus. Stimuli-responsive materials could potentially elicit a therapeutically effective dose without adverse side effects. Polymers responding to different stimuli, such as pH, light, temperature, ultrasound, magnetism, or biomolecules have been investigated as potential drug delivery vehicles. This review describes the most recent advances in "smart" drug delivery systems that respond to one or multiple stimuli.

  6. Structure analysis and performance measurement of Chinese health delivery system

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective: Although evidence has already demonstrated that the performance of Health Delivery System (HDS) varies widely across nations, relatively little is known about the factors that give rise to these variations and the key point to improve the performance besides adjusting system structure. By setup of HDS performance measurement system on the base of association of financial, social, and environmental characteristics, we construct system dynamic model of HDS to simulate the invention policies. Methods:Performance measures were collected from HDS in 31 regions of China and combined with secondary data sources. Multivariate, linear, nonlinear regression and factor analysis models were used to estimate associations between system characteristics and the performance. Results: Performance varied significantly with the size, financial resources and organizational structure of HDS. Performance measurement system of health delivery system was developed to give the rank of all Chinese regions. Conclusion: Performance measurement system of HDS is the basic of HDS modeling by system dynamic.

  7. [Medico-legal incidence of instrumental delivery].

    Science.gov (United States)

    Pierre, F; Jousse, M

    2008-12-01

    The aim of this data analysis on medical liability in professional guidelines on instrumental delivery, is to point out the most common difficulties to which obstetricians are exposed, and to discuss some aspects confronted to literature. Firstly, instrumental delivery is replaced in whole labour ward activity by unpublished results of a national enquiry on instrumental delivery concerning 239 337 deliveries during the year 2007. Then, the analysis of 61 data from legal claims in relation with instrumental deliveries between 1995 and 2007, to allow educational lessons. At last, few specific aspects of judicial expert opinion are confronted to literature and discussed: the effects of debriefing after operative childbirth; discussion on decision making and decision-to-delivery intervals. This chapter is concluded by different points on risk management in labour ward, mainly with potential interest of auditable standards and training with computer assisted simulation.

  8. THE ENVIRONMENTAL IMPACT OF THE DELIVERY OF MINERAL RAW MATERIALS USED FOR BUILDING MATERIALS PRODUCTION TO THE CITY OF ZAGREB AND THE ZAGREB COUNTY

    Directory of Open Access Journals (Sweden)

    Karolina Novak

    2011-12-01

    Full Text Available Mineral raw material transport directly affects a product’s unit price and exhaust gases amounts. Transportation length is proportional to raw material price; its low price enables short transportation distances only. Taking into account stone aggregates delivered to Zagreb, the consequence of exploitation fields closure in the Zagreb area, particularly within the Medvednica Nature Park, we tried to answer the question of the impact of transport distances on the greenhouse gas emissions. Certain models will present environmental impact of the stone aggregate transportation and of nearby city quarries. The generally accepted public opinion on the closure of nearby city quarries as the best solution to environmental pollution will have to be reviewed. Mining works are predestined by mineral resources sites and limited by real possibilities and intentions of the community, therefore the experts, i.e. miners, geologists and other geoscientists, should be actively involved in spatial planning. During the years of intensive construction, millions of tons have been delivered from distances up to 100 km. The question arises whether some more rational solutions could be generated by more appropriate spatial planning? (the paper is published in Croatian

  9. Implementation of compulsory hazard analysis critical control point system and its effect on concentrations of carcass and environmental surface bacterial indicators in United Kingdom red meat slaughterhouses.

    Science.gov (United States)

    Hutchison, Michael L; Thomas, D John I; Small, Alison H; Buncic, Sava; Howell, Mary

    2007-07-01

    Statutory microbiological test results were collected from British meat plants over a 4-year period from June 2002 to May 2006. A total of 49,074 carcass test results from 19,409 cattle, 14,706 sheep, and 14,959 pig swabs and 95,179 environmental test results from surface swabs were obtained. These test results were donated by 94 slaughterhouses, which process about two thirds of the British national annual throughput of cattle, sheep, and pig carcasses. The data were collectively analyzed to determine any historical trends for numbers of total aerobes and Enterobacteriaceae. Significant reductions were observed in the numbers of indicator organisms on carcasses for all three species between 2002 and 2006. Reductions were also observed for numbers of aerobes on environmental and food contact surfaces. There were seasonal differences in bacterial numbers isolated from carcasses. Cattle and sheep carcasses had significantly higher numbers of total aerobes and Enterobacteriaceae in late summer and early autumn, whereas numbers of total aerobes on pig carcasses were higher in winter. Bacterial numbers on environmental surfaces were not influenced by the month that the swab samples were collected. Possible reasons for the observed reductions in bacterial numbers on carcasses and surfaces and the implications for carcass testing for process control purposes are discussed.

  10. Environmental risk modelling and potential sand fly vectors of cutaneous leishmaniasis in Chitral district: a leishmanial focal point of mount Tirich Mir, Pakistan.

    Science.gov (United States)

    Zaidi, Farrah; Fatima, Syeda Hira; Jan, Tehmina; Fatima, Mehreen; Ali, Asad; Khisroon, Muhammad; Adnan, Muhammad; Rasheed, Syed Basit

    2017-09-01

    To provide baseline information about suspected vectors and the incidence, distribution and an active zone of transmission for cutaneous leishmaniasis (CL) in Chitral, Pakistan, using GIS tools; and to investigate the role of environmental factors in the disease dynamics. Two surveys in 2014 and 2016 as a basis for choropleth and environmental risk mapping. A total of 769 captured specimens yielded 14 Phlebotomus and six Sergentomyia species including two potential vectors of CL, i.e. Phlebotomus papatasi and Phlebotomus sergenti. P. papatasi (71%) was dominant, followed by P. sergenti (18%). A choropleth map generated in Arcmap 10.1 based on 1560 CL case reports displayed maximum prevalence (0.92-2.5%) in Ayun, Broz, Charun, Chitral 1 and 2 and Darosh 1 and 2 union councils. An environmental risk map constructed by MaxEnt 3.3.3 defined an active zone of transmission based on leishmaniasis occurrence records (n = 315). The analysis of variable contribution in MaxEnt indicates significance of elevation (54.4%), population density (23.3%) and land use/land cover (6.6%) in CL disease dynamics. The probability of CL increases (0.6-1 on logistic scale) in severely deforested areas, in lowland valleys and in regions with high-population density. © 2017 John Wiley & Sons Ltd.

  11. Environmental Monitoring, Water Quality - BACTERIA_MONITORING_EPA_IN: Bacteria Monitoring Stations and Data Summaries in Indiana, Derived from EPA BASINS 3 (United States Environmental Protection Agency, 1:45,000, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — BACTERIA_MONITORING_EPA_IN is a point shapefile developed by the USEPA BASINS 3.0 program and edited by Bernardin, Lochmueller and Associates. Joinable tables must...

  12. Premature delivery

    Directory of Open Access Journals (Sweden)

    Bernardita Donoso Bernales

    2012-09-01

    Full Text Available Preterm delivery is the single most important cause of perinatal morbidity and mortality. In Chile, preterm births have increased in the past decade, although neonatal morbidity and mortality attributable to it shows a downward trend, thanks to improvements in neonatal care of premature babies, rather than the success of obstetric preventive and therapeutic strategies. This article describes clinical entities, disease processes and conditions that constitute predisposing factors of preterm birth, as well as an outline for the prevention and clinical management of women at risk of preterm birth.

  13. Synergistic enhancement effect of room temperature ionic liquids for cloud point extraction combined with UV-vis spectrophotometric determination nickel in environmental samples

    Science.gov (United States)

    Zeng, Chujie; Xu, Xili; Zhou, Neng; Lin, Yao

    A new method based on enhancement effect of room temperature ionic liquids for cloud point extraction trace amounts of nickel combined with UV-vis spectrophotometric determination was developed. Room temperature ionic liquids (RTILs) and diethyldithiocarbamate (DDTC) were used enhancement reagent and chelating reagent, respectively. The addition of room temperature ionic liquids leads to 3.0 times improvement in the determination of nickel. The nonionic surfactant Triton X-100 was used as the extractant. When the temperature of the system was higher than the cloud point of Triton X-100, Ni-DTC complex was extracted into Triton X-100 and separation of the analyte from the matrix was achieved. Some parameters that influenced cloud point extraction and subsequent determination were evaluated in detail, such as the concentrations of RTILs, DDTC and Triton X-100; pH of sample solution, as well as interferences. Under optimized conditions, an enrichment factor of 72 could be obtained, and the detection limit (LOD) for Ni was 0.5 ng mL-1. Relative standard deviations for five replicate determinations of the standard solution containing 50 ng mL-1 Ni was 3.9%. The proposed method was successfully applied to the determination of nickel in certified reference materials with satisfactory results.

  14. Explanations of sustainable consumption. A search for new starting points for environmental policy; Verklaringen van duurzame consumptie. Een speurtocht naar nieuwe aanknopingspunten voor milieubeleid

    Energy Technology Data Exchange (ETDEWEB)

    Beckers, T.; Ester, P.; Spaargaren, G. [eds.

    1999-07-01

    In two studies attention is paid to the impact of an immaterial consumption pattern on the desires, drives and preferences of human beings. In this study it was expected that a more immaterial interpretation of human needs would cause less burden of the environment. Based on the results of the title search the relation between drives and behavior can be explained. Also insight is given into conceptual models which can be a productive starting point for effective interventions aiming at stimulation of sustainable consumption. 61 refs.

  15. Tipping Point

    Medline Plus

    Full Text Available ... OnSafety CPSC Stands for Safety The Tipping Point Home > 60 Seconds of Safety (Videos) > The Tipping Point ... 24 hours a day. For young children whose home is a playground, it’s the best way to ...

  16. Focal points 2010. Mobility with future - correct investment today. Environmental protection - investment restraint for agriculture? Engine for the climate policy: emission trading; Schwerpunkte 2010. Mobilitaet mit Zukunft - heute richtig investieren. Umweltschutz - Investitionshemmnis fuer die Landwirtschaft? Motor fuer die Klimapolitik: Der Emissionshandel

    Energy Technology Data Exchange (ETDEWEB)

    Ittershagen, Martin; Mavromati, Fotini (comps.)

    2010-04-14

    The publication of the German Federal environmental agency on the focal points 2010 covers the following topics: impetus for an ecological-economic policy; mobility with future -best investment for today: more environmentally compatible investments in traffic infrastructure, better technology - more efficiency, missing charging of environmental cost induces wrong stimuli; environmental protection - investment restraints for agriculture? Engine for climate policy: emission trading; the Federal environmental agency: bridge between science and politics, the Federal environmental agency for mankind and environment; data and facts; publications of the employees.

  17. Report of the Production and Delivery Subgroup

    Energy Technology Data Exchange (ETDEWEB)

    Glass, R; Zalesky, R

    2004-11-01

    The Production and Delivery Subgroup was tasked with evaluating the various options that could be used for hydrogen production and delivery in terms of availability/industry readiness, technical and economic barriers, and environmental considerations. Hydrogen can be produced using a variety of feedstocks and conversion technologies. The feedstock options include water, natural gas, coal, petroleum, methanol, ethanol, biomass, and organic waste streams. Ultimately, using these domestic resources we will be able to produce all the hydrogen we will need for the complete conversion of our transportation infrastructure. The various conversion technologies include electrolysis, reforming (principally of natural gas, but also ethanol and methanol), photobiological and photoelectrochemical, biofermentation, pyrolysis and gasification of biomass and coal, high temperature thermochemical, and catalytic membranes. All of these production technologies are being actively researched by DOE's Office of Hydrogen, Fuel Cells and Infrastructure Technologies (HFCIT); and other offices within DOE support work that complements the HFCIT Program activities. In addition, private industry is also dedicating significant resources to these efforts. In establishing the California Hydrogen Highway Network (CA H2 Net) we must utilize both distributed (that is, hydrogen that is produced at the point of use) as well as centralized production of hydrogen. Because of technical and economic barriers, most of the technologies for hydrogen production listed above will not become practical for either mode of hydrogen production in large quantities until at least the 2015-2030 timeframe. In the near term, that is, the transitional period between now and 2010 when we will establish a widely available hydrogen fueling infrastructure in California, the distributed production options of reforming and electrolysis will play the dominant role. In addition, production of hydrogen at centralized plants

  18. Increase in the boiler's performance in terms of the acid dew point temperature: Environmental advantages of replacing fuels

    Energy Technology Data Exchange (ETDEWEB)

    Blanco, J.M.; Pena, F. [Dpto. Maquinas y Motores Termicos, Escuela Tecnica Superior de Ingenieria, Universidad del Pais Vasco/E.H.U., Alameda de Urquijo s/n (48013) Bilbao (Spain)

    2008-05-15

    The aim of air pre-heaters is to raise the temperature of the combustion air in boilers, using heat recovered from the power plant combustion gases. On the one hand, this paper compares the effects of the acid dew point temperature (ADT) on pre-heaters in a reference thermal power plant for two types of fuel, ''fuel No. 2'' and ''low sulphur fuel'' respectively and on the other hand, it shows how a changeover to this latter fuel would increase the useful lifetime of this equipment, reducing this way cost of maintenance due to the considerable decrease in the area exposed to ADT with the subsequent increase in the boiler's performance. (author)

  19. Comparison and evaluation of cloud point extraction and low-temperature directed crystallization as preconcentration tools for the determination of trace elements in environmental samples

    Energy Technology Data Exchange (ETDEWEB)

    Giokas, D.L.; Eksperiandova, L.P.; Blank, A.B.; Karayannis, M.I

    2004-03-03

    A comparative study between cloud point extraction (CPE) and low-temperature directed crystallization (LTDC) is presented. Trace elements (Cd, Pb, Cr, Cu, Zn, Ni and Fe) were preconcentrated by both methods from model and natural water samples and the results were evaluated with respect to extraction efficiency, accuracy, precision, sample throughput and interferences. Flame atomic absorption spectrometry (FAAS) and inductively coupled plasma atomic emission spectrometry (ICP-AES) were used for the final measurements. The results indicate that these extraction and preconcentration procedures ensure the required accuracy and precision for the reliable identification and quantification of trace elements in natural waters. Drawbacks of each method identified can further assist the analyst towards a better application of each method depending on the target species, the detector employed and the application intended (routine analysis, trace analysis, speciation analysis, etc.)

  20. ACCESS TO LEP POINT 5, CESSY (FRANCE)

    CERN Multimedia

    1999-01-01

    At the public environmental impact enquiry for the LHC project, the municipal authorities at Cessy suggested creating a new approach road to the civil engineering site (Point5) to ensure that materials deliveries by road are kept well away from housing along the Route de la Plaine.Following this recommendation, a track called the Chemin du Milieu has been upgraded into a road, and has been made available for the sole use of construction firms involved in building work at Point 5.The 'Dragados-Seli' consortium will be in charge of site surveillance for the new approach road.With effect from 29 March 1999, the present entrance will be closed to civil engineering firms and reserved for LEP installations maintenance services under the SL Division site managers, Mr. R. Spigato (tel. 160374) and P. Rey (tel. 160375).For obvious security reasons, those needing to use Point 5 are requested to keep the gate locked, even while they are on site, so as to prevent unauthorised persons from gaining access to the civil engi...

  1. Tipping Point

    Medline Plus

    Full Text Available ... Point by CPSC Blogger September 22, 2009 appliance child Childproofing CPSC danger death electrical fall furniture head ... see news reports about horrible accidents involving young children and furniture, appliance and tv tip-overs. The ...

  2. Cloud point extraction and flame atomic absorption spectrometric determination of cadmium(II), lead(II), palladium(II) and silver(I) in environmental samples.

    Science.gov (United States)

    Ghaedi, Mehrorang; Shokrollahi, Ardeshir; Niknam, Khodabakhsh; Niknam, Ebrahim; Najibi, Asma; Soylak, Mustafa

    2009-09-15

    The phase-separation phenomenon of non-ionic surfactants occurring in aqueous solution was used for the extraction of cadmium(II), lead(II), palladium(II) and silver(I). The analytical procedure involved the formation of understudy metals complex with bis((1H-benzo [d] imidazol-2yl)ethyl) sulfane (BIES), and quantitatively extracted to the phase rich in octylphenoxypolyethoxyethanol (Triton X-114) after centrifugation. Methanol acidified with 1molL(-1) HNO(3) was added to the surfactant-rich phase prior to its analysis by flame atomic absorption spectrometry (FAAS). The concentration of BIES, pH and amount of surfactant (Triton X-114) was optimized. At optimum conditions, the detection limits of (3 sdb/m) of 1.4, 2.8, 1.6 and 1.4 ng mL(-1) for Cd(2+), Pb(2+), Pd(2+) and Ag(+) along with preconcentration factors of 30 and enrichment factors of 48, 39, 32 and 42 for Cd(2+), Pb(2+), Pd(2+) and Ag(+), respectively, were obtained. The proposed cloud point extraction has been successfully applied for the determination of metal ions in real samples with complicated matrix such as radiology waste, vegetable, blood and urine samples.

  3. Cloud point extraction and flame atomic absorption spectrometric determination of cadmium(II), lead(II), palladium(II) and silver(I) in environmental samples

    Energy Technology Data Exchange (ETDEWEB)

    Ghaedi, Mehrorang, E-mail: m_ghaedi@mail.yu.ac.ir [Chemistry Department, Yasouj University, Yasouj 75914-353 (Iran, Islamic Republic of); Shokrollahi, Ardeshir [Chemistry Department, Yasouj University, Yasouj 75914-353 (Iran, Islamic Republic of); Niknam, Khodabakhsh [Chemistry Department, Persian Gulf University, Bushehr (Iran, Islamic Republic of); Niknam, Ebrahim; Najibi, Asma [Chemistry Department, Yasouj University, Yasouj 75914-353 (Iran, Islamic Republic of); Soylak, Mustafa [Chemistry Department, University of Erciyes, 38039 Kayseri (Turkey)

    2009-09-15

    The phase-separation phenomenon of non-ionic surfactants occurring in aqueous solution was used for the extraction of cadmium(II), lead(II), palladium(II) and silver(I). The analytical procedure involved the formation of understudy metals complex with bis((1H-benzo [d] imidazol-2yl)ethyl) sulfane (BIES), and quantitatively extracted to the phase rich in octylphenoxypolyethoxyethanol (Triton X-114) after centrifugation. Methanol acidified with 1 mol L{sup -1} HNO{sub 3} was added to the surfactant-rich phase prior to its analysis by flame atomic absorption spectrometry (FAAS). The concentration of BIES, pH and amount of surfactant (Triton X-114) was optimized. At optimum conditions, the detection limits of (3 sdb/m) of 1.4, 2.8, 1.6 and 1.4 ng mL{sup -1} for Cd{sup 2+}, Pb{sup 2+}, Pd{sup 2+} and Ag{sup +} along with preconcentration factors of 30 and enrichment factors of 48, 39, 32 and 42 for Cd{sup 2+}, Pb{sup 2+}, Pd{sup 2+} and Ag{sup +}, respectively, were obtained. The proposed cloud point extraction has been successfully applied for the determination of metal ions in real samples with complicated matrix such as radiology waste, vegetable, blood and urine samples.

  4. 19 CFR 19.39 - Delivery for exportation.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Delivery for exportation. 19.39 Section 19.39... Delivery for exportation. (a) Delivery to land border locations—(1) Land border locations. Land border... exportation from such locations shall be made to the purchaser only beyond the exit point, except as...

  5. PEOPLE & POINTS

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The good news is China’s damaged ecosystem is recover-ing. The bad news is the speed of recovery is excruciatingly slow. Pan Yue, Vice Minister o the State Environmental Protection Administration, recently has a personal experi-ence illustrating just how

  6. PEOPLE & POINTS

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    “I have read similar reports on environment and health many times, released by varied research institutes. Every time, the figures are different.” Zhou Jian, Vice Minister of the State Environmental Protection Administration, questioning a World Bank rep

  7. Evaluation of a cloud point extraction approach for the preconcentration and quantification of trace CuO nanoparticles in environmental waters.

    Science.gov (United States)

    Majedi, Seyed Mohammad; Kelly, Barry C; Lee, Hian Kee

    2014-03-01

    The cloud point extraction (CPE) of commercial copper(II) oxide nanoparticles (CuO NPs, mean diameter of 28nm) in water samples was fully investigated. Factors such as Triton X-114 (TX-114) concentration, pH, incubation temperature and time, were optimized. The effects of CuO NP behavior like agglomeration, dissolution, and surface adsorption of natural organic matter, Cu(2+), and coating chemicals, on its recovery were studied. The results indicated that all the CPE factors had significant effects on the extraction efficiency. An enrichment factor of ∼89 was obtained under optimum CPE conditions. The hydrodynamic diameter of CuO NPs increased to 4-5 μm upon agglomeration of NP-micelle assemblies, and decreased at pH >10.0 at which the extraction efficiency was also lowered. The solubility and therefore, the loss of NPs were greatly enhanced at pH 5 mg C L(-1) and Cu(2+) >2 times that of CuO NPs, lowered and enhanced the extraction efficiency, respectively. Pre-treatment of samples with 3% wv(-1) of hydrogen peroxide and 10 mM of ethylenediaminetetraacetic acid minimized the interferences posed by DOC and Cu(2+), respectively. The decrease in CPE efficiency was also evident for ligands like poly(ethylene glycol). The TX-114-rich phase could be determined with either inductively coupled plasma mass spectrometry following microwave digestion, or graphite furnace atomic absorption spectrometry. The detection limits for CuO NPs were 0.02 and 0.06 μg L(-1) using these techniques, respectively. The optimum sample pre-treatment and CPE conditions were successfully applied to the river and wastewater samples. The relative recoveries of CuO NPs spiked at 5-100 μg L(-1) (as Cu) in these samples were in the range of between 59.2 and 108.2%. The approach demonstrates a robust analytical method for detecting trace levels of CuO NPs at their original states and assessing their exposure risks in real aquatic environments.

  8. On-line cloud point extraction combined with electrothermal vaporization inductively coupled plasma atomic emission spectrometry for the speciation of inorganic antimony in environmental and biological samples

    Energy Technology Data Exchange (ETDEWEB)

    Li Yingjie [Department of Chemistry, Wuhan University, Wuhan 430072 (China); Hu Bin [Department of Chemistry, Wuhan University, Wuhan 430072 (China)]. E-mail: binhu@whu.edu.cn; Jiang Zucheng [Department of Chemistry, Wuhan University, Wuhan 430072 (China)

    2006-08-25

    A new method for the determination of inorganic Sb species by on-line cloud point extraction combined with electrothermal vaporization inductively coupled plasma atomic emission spectrometry (ETV-ICP-AES) is presented and evaluated. The method is based on the complexation of Sb(III) with pyrrolidine dithiocarbamate (PDC) which form an hydrophobic complex at pH 5.5 and subsequently enter surfactant-rich phase at pH 5.5, whereas Sb(V) remained in aqueous solutions. The preconcentration step is mediated by micelles of the non-ionic surfactant Triton X-114 with ammonium pyrrolidine dithiocarbamate (APDC). The micellar system containing the complex was loaded into the FIA manifold at a flow rate of 2.5 mL min{sup -1}, and the surfactant-rich phase was retained in a microcolumn packed with absorbent cotton, at pH 5.5. After the surfactant-rich phase was eluted with 100 {mu}L acetonitrile, it was determined by ETV-ICP-AES. Sb(V) is reduced to Sb(III) by L-cysteine prior to determined total Sb, and its assay is based on subtracting Sb(III) from total antimony. The main factors affecting separation/preconcentration and the vaporization behavior of analyte in graphite tube were investigated in detail. Under the optimized conditions, the precision relative standard deviation (R.S.D.) for eight replicate measurements of 0.2 {mu}g mL{sup -1} Sb(III) was 4.3%. The apparent concentration factor, which is defined as the concentration ratio of the analyte in the final diluted surfactant-rich extract ready for ETV-ICP-AES detection and in the initial solution, was 872 for Sb(III). The limit of detection (LOD) for Sb(III) was 0.09 {mu}g L{sup -1}. The proposed method was successfully applied for the speciation of inorganic antimony in different water samples and urine sample with satisfactory results.

  9. Buccal and sublingual vaccine delivery.

    Science.gov (United States)

    Kraan, Heleen; Vrieling, Hilde; Czerkinsky, Cecil; Jiskoot, Wim; Kersten, Gideon; Amorij, Jean-Pierre

    2014-09-28

    Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination. An important characteristic of mucosal vaccination is its ability to elicit local immune responses, which act against infection at the site of pathogen entry. However, mucosal surfaces are endowed with potent and sophisticated tolerance mechanisms to prevent the immune system from overreacting to the many environmental antigens. Hence, mucosal vaccination may suppress the immune system instead of induce a protective immune response. Therefore, mucosal adjuvants and/or special antigen delivery systems as well as appropriate dosage forms are required in order to develop potent mucosal vaccines. Whereas oral, nasal and pulmonary vaccine delivery strategies have been described extensively, the sublingual and buccal routes have received considerably less attention. In this review, the characteristics of and approaches for sublingual and buccal vaccine delivery are described and compared with other mucosal vaccine delivery sites. We discuss recent progress and highlight promising developments in the search for vaccine formulations, including adjuvants and suitable dosage forms, which are likely critical for designing a successful sublingual or buccal vaccine. Finally, we outline the challenges, hurdles to overcome and formulation issues relevant for sublingual or buccal vaccine delivery.

  10. Re-estimating Environmental Kuznets Curve with Two Spatial Break Points%基于“空间双拐点”估计的环境库兹涅茨曲线

    Institute of Scientific and Technical Information of China (English)

    刘舜佳

    2015-01-01

    基于污染空间扩散这一遗漏掉的非观测变量将传统线性环境库兹涅茨曲线在空间维度扩展成能同时测度环境污染与不同地区经济增长之间关系的“空间双拐点”模型。基于中国31个省区1990—2012年工业废气面板数据的检验结果显示:某一地区工业废气污染与辖域内、外不同地区经济增长之间的关系均呈倒U型,这一结论即使在置换包含不同邻域数的空间权重矩阵之后也具有稳健性,因此遏制工业废气污染需同时逾越辖域内、外经济发展“拐点”。随着产生污染空间扩散的毗邻地区数增加,改善工业废气污染所要求的辖域内经济发展水平趋于严格,辖域内“拐点”到来呈滞后趋势;而改善工业废气污染所要求的辖域外其他地区经济发展水平则随着地理毗邻关系减弱而趋于宽松。政策提示污染治理需国家层面整体推进、缩小区域间经济发展水平差距以及杜绝落后产业的区域间转移。%The classical linear Environmental Kuznets Curve is developed with two spatial break points which can analyzes relationship between environmental pollution and local economic growth , even relationship between environmental pollution and neighbor economic growth . By using a panel data including Chinese 31 provinces from 1990 to 2012 ,the test shows that relationship of reverse U‐shaped curve is depicted between environmental pollution and local economic growth ,that is same to relationship between environmental pollution and neighbor economic growth . The conclusion is robust even using different spatial weighted matrix .So the environmental pollution can be suppressed only when both spatial break points are achieved .Along with polluting districts increasing ,local economy development level has to be promoted to suppress pollution ,w hich causes local break point of economic grow th to be late to reach .Even lower economy development level of

  11. Faster Improvement in Migraine Pain Intensity and Migraine-Related Disability at Early Time Points with AVP-825 (Sumatriptan Nasal Powder Delivery System) versus Oral Sumatriptan: A Comparative Randomized Clinical Trial Across Multiple Attacks from the COMPASS Study.

    Science.gov (United States)

    Lipton, Richard B; McGinley, James S; Shulman, Kenneth J; Wirth, R J; Buse, Dawn C

    2017-09-07

    Fast relief of migraine pain, associated symptoms, and migraine-related disability are priorities in the acute treatment of migraine. Efforts to improve the pharmacokinetic profiles of acute migraine treatments with the aim of providing faster relief include the development of non-oral routes of administration. AVP-825 (ONZETRA(®) Xsail(®) ) is a delivery system containing 22 mg sumatriptan powder that uses a patient's own breath to deliver medication intranasally, targeting the upper posterior nasal cavity beyond the narrow nasal valve, an area lined with vascular mucosa conducive to rapid drug absorption into the systemic circulation. While most studies comparing treatments measure differences in proportions of patients achieving a dichotomous endpoint at fixed time intervals, in this study we compare trajectories of migraine pain and disability over time for AVP-825 versus 100 mg oral sumatriptan tablets. We used data from the COMPASS study (NCT01667679, clinicaltrials.gov), a double-blind, double-dummy, active-comparator, cross-over study of people with a diagnosis of migraine. Participants treated up to five qualifying migraine attacks within 1 hour of onset with either AVP-825 plus placebo tablets or 100 mg oral sumatriptan tablets plus placebo delivery system during the first of two 12-week treatment periods, and then switched treatment sequences to treat up to five more attacks in the second treatment period. Patients recorded ordinal migraine pain intensity and migraine-related disability before dosing (predose), and at 10, 15, 30, 45, 60, 90 and 120 minutes. Three-level ordinal multilevel models accounted for unique data structure (repeated measures nested within attacks for each patient) and tested for treatment differences in migraine pain and migraine-related disability through the first 2 hours of attacks post dose. Among 259 study participants (mean age 40.0 years, 84.6% female, 78.4% white), there was significant between and within person

  12. Polyacrylamide Transport in Water Delivery Canals

    Science.gov (United States)

    Chen, L.; Zhu, J.; Young, M.

    2007-12-01

    Linear, anionic polyacrylamide (PAM) is being considered in the western United States as a technology to reduce seepage in unlined water delivery canals. A broad laboratory and field testing program has been undertaken to understand the benefits and potential environmental impacts of PAM use. The ability to predict the fate and transport of PAM in water delivery canals could prove to be a useful planning tool for PAM application. However, one key area of uncertainty of this type of canal treatment is the hydration, reaction, and settling rates of PAM after the dry powder is added to the canal water. In this study, we have developed a model that incorporates a number of known physical and chemical processes that can affect PAM transport, such as convection, dispersion, dissolution, flocculation, and settling, while solving the governing convection-dispersion transport equation. The model uses a mixed analytical and advanced numerical approach, and implements a transient partitioning of PAM mass between the canal water, the substrate soil, and potentially to open water bodies downstream of the application point. All source terms are modeled based on physical and chemical mechanisms as well as laboratory or field determined parameters. To more closely simulate field treatment of some canals, where PAM application moves upstream in time, the model is capable of implementing either a fixed or mobile upper boundary. In the latter treatment, the PAM can be added discretely or continuously in both time and space. A number of test situations have been simulated thus far, including theoretical and hypothetical cases for a wide range of conditions. The model also performed well when predicting PAM concentrations from a full-scale canal treatment experiment. The model provides a useful tool for predicting PAM fate and transport in water delivery canals, and therefore can play an important role in evaluating the efficacy of PAM application for water resources management

  13. Transdermal drug delivery

    OpenAIRE

    Prausnitz, Mark R.; Langer, Robert

    2008-01-01

    Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs. Second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in clinical products; the ability ...

  14. Key Points of Environmental Impact Assessment for Expressway in Different Areas of Sichuan Province%四川省不同区域高速公路环境影响评价要点

    Institute of Scientific and Technical Information of China (English)

    黄庆; 高洁

    2012-01-01

    高速公路项目由于其线路长、工程量大等特点,不可避免会对生态环境、土地资源、水土流失、人居环境等造成不利影响,本文根据四川各区域的地形地貌、水文地质、生物多样性等环境特点,提出了在不同地区高速公路建设中的环境影响评价要点,从而使环境影响评价内容更具有针对性。%Unavoidably expressway projects cause unfavorable consequences to eco-environment, land resources, water loss- soil erosion and human environment due to the characteristics of long lines and large quantity. This paper presents the key points of environmental impact assessment for expressway constructions according to the corresponding features of geography, hydrogeology, and biodiversity in different areas of Sichuan Province, so that the content of the environmental impact assessment can have more pertinence.

  15. 金属矿山生态环境影响评价要点及矿区生态重建措施%Key points of metal mining environmental impact assessment and measures of mining area ecological reconstruction

    Institute of Scientific and Technical Information of China (English)

    傅学忠

    2012-01-01

    结合丹东地区金属矿山环境影响评价实际情况,分析了金属矿山开发对生态环境的破坏特征,阐述了金属矿山生态环境评价要点;根据矿区土地复垦情况和存在的问题,提出了环评中矿区生态重建措施,为矿区土地复垦和建立矿区复合生态系统提供理论依据.%Combining with the metal mine environmental impact, assessment in Dandong district, the article analyzes the destruction characteristics to the ecological environment by the metal mining and describes the key points of ecological environment evaluation in metal mines. According to the land reclamation situation and the existing problems in mining area, it proposes the mine ecological reconstruction measures in environmental impact assessment. It also provides the theoretical basis for land reclamation and the establishment of mining area compound ecological system.

  16. Research Plan: Foam Delivery of Remedial Amendments to Deep Vadose Zone for Metals and Radionuclides Remediation

    Energy Technology Data Exchange (ETDEWEB)

    Zhong, Lirong; Hart, Andrea T.; Szecsody, James E.; Zhang, Z. F.; Freedman, Vicky L.; Ankeny, Mark; Hull, Laurence; Oostrom, Martinus; Freshley, Mark D.; Wellman, Dawn M.

    2009-01-16

    Research proposals were submitted to the Scientific and Technical Basis for In Situ Treatment of Metals and Radionuclides Technical Working Group under the US Department of Energy (DOE) Environmental Management Office (specifically, EM-22). After a peer review and selection process, the proposal, “Foam Delivery of Remedial Amendments to Deep Vadose Zone for Metals and Radionuclides Remediation,” submitted by Pacific Northwest National Laboratory (PNNL) was selected for support by the program. A research plan was requested for this EM funded project. The overall objective of this project is to develop foam delivery technology for the distribution of remedial amendments to deep vadose zone sediments for in situ immobilization of metal and radionuclide contaminants. The focus of this research in FY 2009 is on the physical aspects of the foam delivery approach. Specific objectives are to 1) study the foam quality (i.e. the gas volume fraction in foam) influence on injection pressure, 2) study the sediment air permeability influence on injection pressure, 3) investigate liquid uptake in sediment and determine whether a water front will be formed during foam delivery, 4) test amendment distance (and mass) delivery by foam from the injection point, 5) study the enhanced sweeping over heterogeneous systems (i.e., low K zones) by foam delivery relative to water-based delivery under vadose zone conditions, and 6) numerically simulate foam delivery processes in the vadose zone. Laboratory scale experiments will be conducted at PNNL to study a range of basic physical aspects of the foam propagation in sediments, including foam quality and sediment permeability influence on injection pressure, liquid uptake, and foam sweeping across heterogeneous systems. This study will be augmented with separate studies to be conducted at MSE Technology Applications, Inc. (MSE) to evaluate foam transport and amendment delivery at the intermediate-scale. The results of intermediate

  17. Assisted Vaginal Delivery

    Science.gov (United States)

    ... be needed. What are the risks for my baby if I have assisted vaginal delivery? Although the overall rate of injury to the baby as a result of assisted vaginal delivery is low, there still is a risk of ...

  18. eDelivery

    Data.gov (United States)

    US Agency for International Development — eDelivery provides the electronic packaging and delivery of closed and complete OPM investigation files to government agencies, including USAID, in a secure manner....

  19. Contract for access to the public power transportation network for an eligible consuming site. Particular conditions at the delivery point; Contrat d'acces au reseau public de transport d'electricte pour un site consommateur eligible. Conditions particulieres au point de livraison

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    On 1 November 2002, the new tariffs for the utilisation of the public power transmission and distribution networks, defined by decree no 2002-1014 of 19 July 2002, will come into effect. A new contract for access to the transmission network has been drawn up in co-operation with the Energy Regulation Commission (CRE) so as to be able to include these new tariffs. This new contract also takes into account the expectations expressed by the users of the transmission network concerning the energy delivery agreement used since the coming into effect of the European Directive on the opening of the electricity market in February 1999. On 31 October 2002, RTE is publishing a new version of the contract for access to the Public Transmission Networks. On 4 August 2003, RTE updated the particular conditions of the contract for access to the public transmission networks. This update takes into account the French regulator's deliberation dated 22/05/03, on the handling of eligible sites indirectly connected to public transmission systems. This document is a model form of the particular conditions of the contract. It comprises the following parts: purpose and contractual perimeter, connection to the public transportation network, metering and deductions, subscribed power, development, exploitation and maintenance of facilities, power continuity and quality, liability, tariffing and conditions of payment, declaration of the balancing actor, general dispositions. 7 models of forms of notification, demand, authorization, agreement, declaration etc.. are given in appendixes.

  20. Assisted delivery with forceps

    Science.gov (United States)

    ... technique your doctor may use to deliver the baby is called vacuum assisted delivery . When is a Forceps Delivery Needed? Even after ... Problems with urinating or moving your bowels after delivery For the baby, the risks are: Bumps, bruises or marks on ...

  1. Comparison of rapid MMP-8 and interleukin-6 point-of-care tests to identify intra-amniotic inflammation/infection and impending preterm delivery in patients with preterm labor and intact membranes().

    Science.gov (United States)

    Chaemsaithong, Piya; Romero, Roberto; Docheva, Nikolina; Chaiyasit, Noppadol; Bhatti, Gaurav; Pacora, Percy; Hassan, Sonia S; Yeo, Lami; Erez, Offer

    2017-03-01

    Among patients presenting with preterm labor and intact membranes, those with intra-amniotic inflammation have adverse obstetrical and neonatal outcomes. The diagnosis of intra-amniotic inflammation can easily be made by detecting an elevated concentration of the cytokine interleukin (IL)-6 or the enzyme neutrophil collagenase, also known as matrix metalloproteinase (MMP)-8. The diagnostic performances of MMP-8 and IL-6 enzyme-linked immunosorbent assay tests are similar. Recently, a rapid test has become available for point-of-care determination of either MMP-8 or IL-6. The objectives of this study were to compare the diagnostic indices and predictive values between the rapid MMP-8 and IL-6 tests for the identification of intra-amniotic inflammation in patients with preterm labor and intact membranes. We performed a retrospective cohort study including 124 women with singleton pregnancies who presented with symptoms of preterm labor and underwent transabdominal amniocentesis for the evaluation of microbial invasion of the amniotic cavity (MIAC). MIAC was defined according to amniotic fluid culture results (aerobic and anaerobic bacteria as well as genital Mycoplasmas). Amniotic fluid white blood cell (WBC) counts were determined using a hemocytometer chamber. An elevated amniotic fluid MMP-8 concentration was assessed using Yoon's MMP-8 Check(®) (cutoff: 10 ng/mL). An elevated amniotic fluid IL-6 concentration was scored when there was a positive result for the lateral flow-based immunoassay (cutoff: ≥745 pg/mL and ≥1000 pg/mL). In order to objectively compare rapid MMP-8 and rapid IL-6 tests to identify intra-amniotic inflammation, an amniotic fluid WBC count of ≥50 cells/mm(3) was used to define intra-amniotic inflammation. (1) The rapid tests had the same sensitivity for the detection of intra-amniotic inflammation [85.7% (18/21) for all]; (2) the specificity of the rapid MMP-8 test was higher than that of the rapid IL-6 test (cutoff: 745

  2. Designing and assessing a sustainable networked delivery (SND) system: hybrid business-to-consumer book delivery case study.

    Science.gov (United States)

    Kim, Junbeum; Xu, Ming; Kahhat, Ramzy; Allenby, Braden; Williams, Eric

    2009-01-01

    We attempted to design and assess an example of a sustainable networked delivery (SND) system: a hybrid business-to-consumer book delivery system. This system is intended to reduce costs, achieve significant reductions in energy consumption, and reduce environmental emissions of critical local pollutants and greenhouse gases. The energy consumption and concomitant emissions of this delivery system compared with existing alternative delivery systems were estimated. We found that regarding energy consumption, an emerging hybrid delivery system which is a sustainable networked delivery system (SND) would consume 47 and 7 times less than the traditional networked delivery system (TND) and e-commerce networked delivery system (END). Regarding concomitant emissions, in the case of CO2, the SND system produced 32 and 7 times fewer emissions than the TND and END systems. Also the SND system offer meaningful economic benefit such as the costs of delivery and packaging, to the online retailer, grocery, and consumer. Our research results show that the SND system has a lot of possibilities to save local transportation energy consumption and delivery costs, and reduce environmental emissions in delivery system.

  3. Phase II modification of the Water Availability Tool for Environmental Resources (WATER) for Kentucky: The sinkhole-drainage process, point-and-click basin delineation, and results of karst test-basin simulations

    Science.gov (United States)

    Taylor, Charles J.; Williamson, Tanja N.; Newson, Jeremy K.; Ulery, Randy L.; Nelson, Hugh L.; Cinotto, Peter J.

    2012-01-01

    This report describes Phase II modifications made to the Water Availability Tool for Environmental Resources (WATER), which applies the process-based TOPMODEL approach to simulate or predict stream discharge in surface basins in the Commonwealth of Kentucky. The previous (Phase I) version of WATER did not provide a means of identifying sinkhole catchments or accounting for the effects of karst (internal) drainage in a TOPMODEL-simulated basin. In the Phase II version of WATER, sinkhole catchments are automatically identified and delineated as internally drained subbasins, and a modified TOPMODEL approach (called the sinkhole drainage process, or SDP-TOPMODEL) is applied that calculates mean daily discharges for the basin based on summed area-weighted contributions from sinkhole drain-age (SD) areas and non-karstic topographically drained (TD) areas. Results obtained using the SDP-TOPMODEL approach were evaluated for 12 karst test basins located in each of the major karst terrains in Kentucky. Visual comparison of simulated hydrographs and flow-duration curves, along with statistical measures applied to the simulated discharge data (bias, correlation, root mean square error, and Nash-Sutcliffe efficiency coefficients), indicate that the SDPOPMODEL approach provides acceptably accurate estimates of discharge for most flow conditions and typically provides more accurate simulation of stream discharge in karstic basins compared to the standard TOPMODEL approach. Additional programming modifications made to the Phase II version of WATER included implementation of a point-and-click graphical user interface (GUI), which fully automates the delineation of simulation-basin boundaries and improves the speed of input-data processing. The Phase II version of WATER enables the user to select a pour point anywhere on a stream reach of interest, and the program will automatically delineate all upstream areas that contribute drainage to that point. This capability enables

  4. Determination of ultra-trace amount methyl-, phenyl- and inorganic mercury in environmental and biological samples by liquid chromatography with inductively coupled plasma mass spectrometry after cloud point extraction preconcentration.

    Science.gov (United States)

    Chen, Jianguo; Chen, Hengwu; Jin, Xianzhong; Chen, Haiting

    2009-02-15

    The cloud point extraction (CPE) preconcentration of ultra-trace amount of mercury species prior to reverse-phase high performance liquid chromatography (HPLC) with inductively coupled plasma mass spectrometry (ICP-MS) detection was studied. Mercury species including methyl-, ethyl-, phenyl- and inorganic mercury were transformed into hydrophobic chelates by reaction with sodium diethyldithiocarbamate, and the hydrophobic chelates were extracted into a surfactant-rich phase of Triton X-114 upon heating in a water bath at 40 degrees C. Ethylmercury was found partially decomposed during the CPE process, and was not included in the developed method. Various experimental conditions affecting the CPE preconcentration, HPLC separation, and ICP-MS determination were optimized. Under the optimized conditions, detection limits of 13, 8 and 6 ng l(-1) (as Hg) were achieved for MeHg(+), PhHg(+) and Hg(2+), respectively. Seven determinations of a standard solution containing the three mercury species each at 0.5 ng ml(-1) level produced relative standard deviations of 5.3, 2.3 and 4.4% for MeHg(+), PhHg(+) and Hg(2+), respectively. The developed method was successfully applied for the determination of the three mercury species in environmental water samples and biological samples of human hair and ocean fish.

  5. Colloidal drug delivery systems in vaccine delivery.

    Science.gov (United States)

    Beg, Sarwar; Samad, Abdus; Nazish, Iram; Sultana, Ruksar; Rahman, Mahfoozur; Ahmad, Md Zaki; Akbar, Md

    2013-01-01

    Vaccines play a vital role in the field of community medicine to combat against several diseases of human existence. Vaccines primarily trigger the acquired immune system to develop long-lasting immunity against pathogens. Conventional approaches for vaccine delivery lacks potential to target a particular antigen to develop acquired immunity by specific antibodies. Recent advancements in vaccine delivery showed that inclusion of adjuvants in vaccine formulations or delivery of them in a carrier helps in achieving desired targeting ability, reducing the immunogenicity and significant augmentation in the immune response. Colloidal carriers (liposomes, niosomes, microspheres, proteosomes, virosomes and virus like particles (VLPs), antigen cochleates, dendrimers and carbon nanotubes) have been widely explored for vaccine delivery. Further, surface engineering of these carriers with ligands, functional moieties and monoclonal antibodies tend to enhance the immune recognition potential of vaccines by differentiation of antigen specific memory T-cells. The current review, therefore, provides an updated account on the recent advancements in various colloidal delivery systems in vaccine delivery, outlining the mechanism of immune response initiated by them along with potential applications and marketed instances in an explicit manner.

  6. National Environmental Research Parks

    Energy Technology Data Exchange (ETDEWEB)

    1994-07-01

    The National Environmental Research Parks are outdoor laboratories that provide opportunities for environmental studies on protected lands that act as buffers around Department of Energy (DOE) facilities. The research parks are used to evaluate the environmental consequences of energy use and development as well as the strategies to mitigate these effects. They are also used to demonstrate possible environmental and land-use options. The seven parks are: Fermilab National Environmental Research Park; Hanford National Environmental Research Park; Idaho National Environmental Research Park; Los Alamos National Environmental Research Park; Nevada National Environmental Research Park; Oak Ridge National Environmental Research Park; and Savannah River National Environmental Research Park. This document gives an overview of the events that led to the creation of the research parks. Its main purpose is to summarize key points about each park, including ecological research, geological characteristics, facilities, and available databases.

  7. Setting Environmental Standards

    Science.gov (United States)

    Fishbein, Gershon

    1975-01-01

    Recent court decisions have pointed out the complexities involved in setting environmental standards. Environmental health is composed of multiple causative agents, most of which work over long periods of time. This makes the cause-and-effect relationship between health statistics and environmental contaminant exposures difficult to prove in…

  8. E-learning strategies of higer education institutions : an exploraty study into the influence of environmental contingencies on strategic choices of higher education institutions with respect to integrating e-learning in their education delivery and support processes

    NARCIS (Netherlands)

    Boezerooij, Petra

    2006-01-01

    Looking back at the main research question of this thesis ¿how do higher education institutions differ in their strategic choices with respect to integrating e- Learning into their educational delivery processes and how can these differences be explained?¿ the results of this study showed that highe

  9. Content delivery network and regulation

    Institute of Scientific and Technical Information of China (English)

    PENG Jiu-sheng; LIANG Xiong-jian

    2006-01-01

    First, this article provides an introduction to the content delivery network (CDN), which has wide prospects but is still in its early stages in China. Second, this article depicts the present situation and the developing characteristics of CDN in China. Elaborating on the above-mentioned two points, this article identifies the numerous problems that are encountered during the development of CDN, such as indistinct service positioning and the hidden troubles of information security.Finally, this article presents several countermeasures for handling the problems, such as opening the market widely,making a rational service positioning, strengthening the regulation on information security, and punishing illegal operations and unfair competition.

  10. Project delivery system (PDS)

    CERN Document Server

    2001-01-01

    As business environments become increasingly competitive, companies seek more comprehensive solutions to the delivery of their projects. "Project Delivery System: Fourth Edition" describes the process-driven project delivery systems which incorporates the best practices from Total Quality and is aligned with the Project Management Institute and ISO Quality Standards is the means by which projects are consistently and efficiently planned, executed and completed to the satisfaction of clients and customers.

  11. Cesarean Delivery in Adolescents.

    Science.gov (United States)

    Katz Eriksen, Jennifer L; Melamed, Alexander; Clapp, Mark A; Little, Sarah E; Zera, Chloe

    2016-10-01

    To examine the effect of maternal age on indication for primary cesarean delivery in low-risk nulliparous women. Retrospective cohort study. Urban academic tertiary care center. Nulliparous women younger than 35 years of age delivering vertex-presenting singletons at term. Participants underwent spontaneous, operative or cesarean delivery. Mode of delivery, indication, and timing of cesarean delivery. Adolescents were half as likely to undergo cesarean delivery overall (odds ratio [OR], 0.48; 95% confidence interval [CI], 0.43-0.54), and more than one-third less likely to undergo cesarean delivery in labor (OR, 0.59; 95% CI, 0.53-0.66). Adjustment for potential confounders did not alter the strength of these associations. Adolescents were half as likely to undergo cesarean delivery for failure to progress (OR, 0.49; 95% CI, 0.43-0.54). There was no difference in the odds of cesarean delivery for nonreassuring fetal status (OR, 0.91; 95% CI, 0.77-1.06), or genital herpes (OR, 1.44; 95% CI, 0.57-3.68). Induction, macrosomia, oxytocin augmentation, and any labor complication were all associated with increased risk of cesarean delivery. There was no difference in the duration of second stage for adolescents who delivered by cesarean delivery compared with adults (240.0 vs 237.7 minutes; P = .84), but adolescents who delivered vaginally had a second stage that was one-third shorter than adults (62.5 vs 100.3 minutes; P cesarean delivery overall, and 40% less likely to undergo a primary cesarean delivery in labor, even after adjustment for multiple maternal, neonatal, and labor characteristics. This difference is not explained by differences in the duration of the second stage of labor. Copyright © 2016 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  12. Buccal drug delivery.

    Science.gov (United States)

    Smart, John D

    2005-05-01

    Buccal formulations have been developed to allow prolonged localised therapy and enhanced systemic delivery. The buccal mucosa, however, while avoiding first-pass effects, is a formidable barrier to drug absorption, especially for biopharmaceutical products (proteins and oligonucleotides) arising from the recent advances in genomics and proteomics. The buccal route is typically used for extended drug delivery, so formulations that can be attached to the buccal mucosa are favoured. The bioadhesive polymers used in buccal drug delivery to retain a formulation are typically hydrophilic macro-molecules containing numerous hydrogen bonding groups. Newer second-generation bioadhesives have been developed and these include modified or new polymers that allow enhanced adhesion and/or drug delivery, in addition to site-specific ligands such as lectins. Over the last 20 years a wide range of formulations has been developed for buccal drug delivery (tablet, patch, liquids and semisolids) but comparatively few have found their way onto the market. Currently, this route is restricted to the delivery of a limited number of small lipophilic molecules that readily cross the buccal mucosa. However, this route could become a significant means for the delivery of a range of active agents in the coming years, if the barriers to buccal drug delivery are overcome. In particular, patient acceptability and the successful systemic delivery of large molecules (proteins, oligonucleotides and polysaccharides) via this route remains both a significant opportunity and challenge, and new/improved technologies may be required to address these.

  13. Status of the CLIC Beam Delivery System

    CERN Document Server

    Tomás, R; Resta López, J; Rumolo, G; Schulte, D; Schuler, P; Bolzon, B; Brunetti, L; Brunetti, L; Geffroy, N; Jeremie, A; Seryi, A; Angal-Kalinin, D; Jackson, F

    2010-01-01

    The CLIC Beam Delivery System (BDS) is experiencing the careful revision from a large number of world wide experts. This was particularly enhanced by the successful CLIC’08 workshop held at CERN. Numerous new ideas, improvements and critical points are arising, establishing the path towards the Conceptual Design Report by 2010.

  14. E-Skills of Delivery Managers

    DEFF Research Database (Denmark)

    Schlichter, Bjarne Rerup

    Geographically distributed development of information systems calls for a set of specific skills among middle managers, facilitating outsourced services. With a theoretical point of departure and a resource-based view on strategy, this paper explores the e-skills of a group of so-called ‘Delivery...

  15. Manhole cover point locations across Guam's developed areas

    Data.gov (United States)

    U.S. Environmental Protection Agency — This is a point feature dataset with points across Guam's developed areas. The points represent manhole cover locations, ground elevation and manhole access depth.

  16. Nonviral Vectors for Gene Delivery

    Science.gov (United States)

    Baoum, Abdulgader Ahmed

    2011-12-01

    The development of nonviral vectors for safe and efficient gene delivery has been gaining considerable attention recently. An ideal nonviral vector must protect the gene against degradation by nuclease in the extracellular matrix, internalize the plasma membrane, escape from the endosomal compartment, unpackage the gene at some point and have no detrimental effects. In comparison to viruses, nonviral vectors are relatively easy to synthesize, less immunogenic, low in cost, and have no limitation in the size of a gene that can be delivered. Significant progress has been made in the basic science and applications of various nonviral gene delivery vectors; however, the majority of nonviral approaches are still inefficient and often toxic. To this end, two nonviral gene delivery systems using either biodegradable poly(D,L-lactide- co-glycolide) (PLG) nanoparticles or cell penetrating peptide (CPP) complexes have been designed and studied using A549 human lung epithelial cells. PLG nanoparticles were optimized for gene delivery by varying particle surface chemistry using different coating materials that adsorb to the particle surface during formation. A variety of cationic coating materials were studied and compared to more conventional surfactants used for PLG nanoparticle fabrication. Nanoparticles (˜200 nm) efficiently encapsulated plasmids encoding for luciferase (80-90%) and slowly released the same for two weeks. After a delay, moderate levels of gene expression appeared at day 5 for certain positively charged PLG particles and gene expression was maintained for at least two weeks. In contrast, gene expression mediated by polyethyleneimine (PEI) ended at day 5. PLG particles were also significantly less cytotoxic than PEI suggesting the use of these vehicles for localized, sustained gene delivery to the pulmonary epithelium. On the other hand, a more simple method to synthesize 50-200 nm complexes capable of high transfection efficiency or high gene knockdown was

  17. Prediction of preterm delivery

    NARCIS (Netherlands)

    Wilms, F.F.

    2014-01-01

    Preterm delivery is in quantity and in severity an important issue in the obstetric care in the Western world. There is considerable knowledge on maternal and obstetric risk factors of preterm delivery. Of the women presenting with preterm labor, the majority is pregnant with a male fetus and in

  18. Prediction of preterm delivery

    NARCIS (Netherlands)

    Wilms, F.F.

    2014-01-01

    Preterm delivery is in quantity and in severity an important issue in the obstetric care in the Western world. There is considerable knowledge on maternal and obstetric risk factors of preterm delivery. Of the women presenting with preterm labor, the majority is pregnant with a male fetus and in Cau

  19. Delivery by Cesarean Section

    Science.gov (United States)

    ... often when: The mother has had a previous baby by Cesarean delivery The obstetrician feels that the baby’s health might ... lost time. Don’t be surprised if your baby is still affected by the anesthesia for six to twelve hours after delivery and appears a little sleepy. If you’re ...

  20. Vacuum-assisted delivery

    Science.gov (United States)

    ... a handle on the cup to move the baby through the birth canal. When is Vacuum-assisted Delivery Needed? Even after your cervix is fully dilated ( ... delivers the baby's head, you will push the baby the rest of the way out. After delivery, you can hold your baby on your tummy ...

  1. Active Learning: A PowerPoint Tutorial

    Science.gov (United States)

    Gareis, Elisabeth

    2007-01-01

    Individual or group presentations are common assignments in business communication courses, and many students use PowerPoint slides as audiovisual support. Frequently, curriculum constraints don't allow instructors much time to teach effective design and delivery of presentation graphics in their courses; guidelines in the form of minilectures or…

  2. Hamburgian weapon delivery technology: a quantitative comparative approach

    DEFF Research Database (Denmark)

    Riede, Felix

    2010-01-01

    cran). Numerous studies have addressed the question of whether these points tipped arrows fired from bows, darts launched with the help of spear-throwers, or some other projectile delivery weapon. This paper approaches the question of Hamburgian weapon delivery technology from a quantitative...... comparative angle. Lithic metric data as well as information on presumed Hamburgian projectile shafts are used to demonstrate that the bow-and-arrow was the most likely weapon delivery method. This is reflected in the shape similarity with both later prehistoric arrow-points and shafts of the Ahrensburgian...

  3. Dosimetric verification of RapidArc treatment delivery

    DEFF Research Database (Denmark)

    Korreman, Stine; Medin, Joakim; Kjaer-Kristoffersen, Flemming

    2009-01-01

    doses. All plans were then delivered several times to verify consistency of the delivery. Gamma analysis was used to verify the correspondence between dose distributions. The temporal resolution of the delivery was analysed by investigating the arc segments between control points separately. RESULTS......: Overall, good agreement was observed between measured and calculated doses in most cases with gamma values above 1 in >95% of measured points. The reproducibility of delivery was also very high. Gamma analysis between two consecutive runs of the same delivery plan generally showed gamma values above 1......PURPOSE: Recently, Varian Medical Systems have announced the introduction of a new treatment technique, in which dose is delivered over a single gantry rotation with variable MLC positions, dose rate and gantry speed. In February 2008, a preclinical installation of the RapidArc beam delivery...

  4. Global Delivery Models

    DEFF Research Database (Denmark)

    Manning, Stephan; Larsen, Marcus M.; Bharati, Pratyush

    2013-01-01

    This article examines antecedents and performance implications of global delivery models (GDMs) in global business services. GDMs require geographically distributed operations to exploit both proximity to clients and time-zone spread for efficient service delivery. We propose and empirically show...... that service providers who differentiate based on speed of service delivery are likely to set up GDM structures, and that these structures positively affect deal renewal rates if speed is important for clients in selecting vendors. Findings imply that, as co-location becomes less necessary for providing...... digitalized services, time zones increasingly affect....

  5. Global Delivery Models

    DEFF Research Database (Denmark)

    Manning, Stephan; Møller Larsen, Marcus; Bharati, Pratyush

    We investigate antecedents and contingencies of location configurations supporting global delivery models (GDMs) in global outsourcing. GDMs are a new form of IT-enabled client-specific investment promoting services provision integration with clients by exploiting client proximity and time......-zone spread allowing for 24/7 service delivery and access to resources. Based on comprehensive data we show that providers are likely to establish GDM configurations when clients value access to globally distributed talent pools and speed of service delivery, and in particular when services are highly...

  6. Global Delivery Models

    DEFF Research Database (Denmark)

    Manning, Stephan; Møller Larsen, Marcus; Bharati, Pratyush

    We investigate antecedents and contingencies of location configurations supporting global delivery models (GDMs) in global outsourcing. GDMs are a new form of IT-enabled client-specific investment promoting services provision integration with clients by exploiting client proximity and time......-zone spread allowing for 24/7 service delivery and access to resources. Based on comprehensive data we show that providers are likely to establish GDM configurations when clients value access to globally distributed talent pools and speed of service delivery, and in particular when services are highly...... commoditized. Findings imply that coordination across time zones increasingly affects international operations in business-to-business and born-global industries....

  7. Focus on Delivery

    DEFF Research Database (Denmark)

    Hasman, Kirsten; Barfoed, Anne

    2016-01-01

    (2). It is, however, not clarified which of the multifaceted aspects of preventing perineal injury that might explain the decrease (3). Aims: We hypothesized that the use of structured reflection on a clinical practice by midwives and midwifery students would increase both parts’ knowledge on how...... attended a delivery. The tool was developed based on five categories: communication, pace, ergonomic positions, perineal support in the chosen birth position and delivery of the shoulders, and five predefined questions guided an overall reflection upon practice. After a delivery a project midwife, who had...

  8. Water Sample Points, Navajo Nation, 2000, USACE

    Data.gov (United States)

    U.S. Environmental Protection Agency — This point shapefile presents the locations and results for water samples collected on the Navajo Nation by the US Army Corps of Engineers (USACE) for the US...

  9. Region 9 NPL Sites (Points) 2015

    Data.gov (United States)

    U.S. Environmental Protection Agency — NPL site point locations for the US EPA, Region 9. NPL (National Priorities List) sites are hazardous waste sites that are eligible for extensive long-term cleanup...

  10. Transdermal delivery of proteins.

    Science.gov (United States)

    Kalluri, Haripriya; Banga, Ajay K

    2011-03-01

    Transdermal delivery of peptides and proteins avoids the disadvantages associated with the invasive parenteral route of administration and other alternative routes such as the pulmonary and nasal routes. Since proteins have a large size and are hydrophilic in nature, they cannot permeate passively across the skin due to the stratum corneum which allows the transport of only small lipophilic drug molecules. Enhancement techniques such as chemical enhancers, iontophoresis, microneedles, electroporation, sonophoresis, thermal ablation, laser ablation, radiofrequency ablation and noninvasive jet injectors aid in the delivery of proteins by overcoming the skin barrier in different ways. In this review, these enhancement techniques that can enable the transdermal delivery of proteins are discussed, including a discussion of mechanisms, sterility requirements, and commercial development of products. Combination of enhancement techniques may result in a synergistic effect allowing increased protein delivery and these are also discussed.

  11. Environmental assessment: Perform open marsh water management on the former popular point mosquito control impoundment and adjacent salt marsh: Barnegat National Wildlife Refuge [now a division of the Edwin B. Forsythe National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This environmental assessment evaluates a proposal by the Ocean County Mosquito Control Extermination Commission to restore a tidal salt marsh on the Barnegat...

  12. A branch-and-cut-and-price approach for the pickup and delivery problem with shuttle routes

    DEFF Research Database (Denmark)

    Masson, Renaud; Røpke, Stefan; Lehuédé, Fabien

    2014-01-01

    The Pickup and Delivery Problem with Shuttle routes (PDPS) is a special case of the Pickup and Delivery Problem with Time Windows (PDPTW) where the trips between the pickup points and the delivery points can be decomposed into two legs. The first leg visits only pickup points and ends at some...... delivery point. The second leg is a direct trip – called a shuttle – between two delivery points. This optimization problem has practical applications in the transportation of people between a large set of pickup points and a restricted set of delivery points.This paper proposes three mathematical models...... the quality of linear relaxations. The method is evaluated on generated and real-world instances containing up to 193 transportation requests. Instances with up to 87 customers are solved to optimality within a computation time of one hour....

  13. MUCOSAL DRUG DELIVERY SYSTEM

    OpenAIRE

    Madan Jyotsana; Banode Sagar; Dangi Mahesh

    2010-01-01

    The process of mucoadhesion involving a polymeric drug delivery system is a complex one that includes processes such as wetting, adsorption and interpenetration of polymer chains. The success and degree of mucoadhesion bonding is influenced by various polymer-based properties such as the degree of cross-linking, chain length and the presence of various functional groupings. The attractiveness of mucosal-targeted controlled drug delivery of active pharmaceutical ingredients, has led formulatio...

  14. Protein-Based Drug-Delivery Materials

    Directory of Open Access Journals (Sweden)

    Dave Jao

    2017-05-01

    Full Text Available There is a pressing need for long-term, controlled drug release for sustained treatment of chronic or persistent medical conditions and diseases. Guided drug delivery is difficult because therapeutic compounds need to survive numerous transport barriers and binding targets throughout the body. Nanoscale protein-based polymers are increasingly used for drug and vaccine delivery to cross these biological barriers and through blood circulation to their molecular site of action. Protein-based polymers compared to synthetic polymers have the advantages of good biocompatibility, biodegradability, environmental sustainability, cost effectiveness and availability. This review addresses the sources of protein-based polymers, compares the similarity and differences, and highlights characteristic properties and functionality of these protein materials for sustained and controlled drug release. Targeted drug delivery using highly functional multicomponent protein composites to guide active drugs to the site of interest will also be discussed. A systematical elucidation of drug-delivery efficiency in the case of molecular weight, particle size, shape, morphology, and porosity of materials will then be demonstrated to achieve increased drug absorption. Finally, several important biomedical applications of protein-based materials with drug-delivery function—including bone healing, antibiotic release, wound healing, and corneal regeneration, as well as diabetes, neuroinflammation and cancer treatments—are summarized at the end of this review.

  15. Mode of delivery in Multiple Sclerosis

    Directory of Open Access Journals (Sweden)

    Emanuele D’Amico

    2013-08-01

    Full Text Available Multiple sclerosis (MS is a chronic immune-mediated disorder of the central nervous system, affecting women of childbearing age. Little is known about the possible association between mode of delivery and the risk of MS in offspring. Delivery represents a unique event in a woman’s lifetime, with complex mechanisms controlling human parturition. Concurrent with the trend of increasing numbers of caesarean deliveries (CD, there has been an increasing frequency of autoimmune diseases such as MS. Several theories have emerged suggesting that environmental influences are contributing to this phenomenon. The data available in literature seem reassuring for women with MS, suggesting that the disease is not associated with adverse pregnancy or birth outcomes. On the other hand, there is little information in the literature regarding the role of mode of delivery in predicting the postpartum disease activity, pregnancy, and birth outcomes in women with MS. The aim of our review is to provide a brief summary of the available data on the role of mode of delivery in MS, and the eventual correlation with disease outcome.

  16. Organizing polarized delivery of exosomes at synapses.

    Science.gov (United States)

    Mittelbrunn, Maria; Vicente-Manzanares, Miguel; Sánchez-Madrid, Francisco

    2015-04-01

    Exosomes are extracellular vesicles that transport different molecules between cells. They are formed and stored inside multivesicular bodies (MVB) until they are released to the extracellular environment. MVB fuse along the plasma membrane, driving non-polarized secretion of exosomes. However, polarized signaling potentially directs MVBs to a specific point in the plasma membrane to mediate a focal delivery of exosomes. MVB polarization occurs across a broad set of cellular situations, e.g. in immune and neuronal synapses, cell migration and in epithelial sheets. In this review, we summarize the current state of the art of polarized MVB docking and the specification of secretory sites at the plasma membrane. The current view is that MVB positioning and subsequent exosome delivery requires a polarizing, cytoskeletal dependent-trafficking mechanism. In this context, we propose scenarios in which biochemical and mechanical signals could drive the polarized delivery of exosomes in highly polarized cells, such as lymphocytes, neurons and epithelia.

  17. Exploration of Environmental Management

    Directory of Open Access Journals (Sweden)

    Li Shushu

    2012-09-01

    Full Text Available On the basis of domestic and international research, this article takes research on peasant household and agricultural managements as base points, aims to build environmental management model, establish government-led, an effective environmental management mechanism between the government and peasant household. Analyzes the role of peasant household’ environmental management in the regional environmental improvement from the aspect of theoretical analysis and analyze significant factors affecting peasant household voluntarily to improve the rural environment and the effective ways of rural environmental governance.

  18. Environmental Control over the Primary Aluminum Industry

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正> To strengthen environmental control over theprimary aluminum industry,the State Environ-mental Protection Administration of China hasrecently issued a notice addressing the follow-ing points:Strengthening environmental control over theexisting primary aluminum companies

  19. [Conception of Ashi points].

    Science.gov (United States)

    Xu, Rong-dong; Li, Heng

    2005-04-01

    In the light of obscure conception of Ashi points in the circle of acupuncture and moxibustion at present, this article tries to clarify the origin and definition of Ashi points by textual research of literatures. It is put forward that Ashi points are not the same with "tender spot" and "Buding point, Tianying point", but are some special responding points, including regular points and extra points, when the organism is ill. When these points are pressed the organism will be comfortable or painful. And the definition, location and clinical location method of Ashi points are proposed.

  20. 15 CFR 291.3 - Environmental tools and techniques projects.

    Science.gov (United States)

    2010-01-01

    ... activity, and “customer satisfaction” measures of performance. (6) Management experience and plans... organizations in providing environmentally-related services to smaller manufacturers and which may also be of..., manufacturing assessment tools, environmental benchmarking tools, training delivery programs,...

  1. Site environmental programs

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, J.W.; Hanf, R.W.

    1995-06-01

    This section of the 1994 Hanford Site Environmental Report summarizes the site environmental programs. Effluent monitoring and environmental surveillance programs monitor for impacts from operations in several areas. The first area consists of the point of possible release into the environment. The second area consists of possible contamination adjacent to DOE facilities, and the third area is the general environment both on and off the site.

  2. Hazardous Material Storage Facilities and Sites - WASTE_DISPOSAL_STORAGE_HANDLING_IDEM_IN: Waste Site Locations for Disposal, Storage and Handling of Solid Waste and Hazardous Waste in Indiana (Indiana Department of Environmental Management, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — WASTE_DISPOSAL_STORAGE_HANDLING_IDEM_IN is a point shapefile that contains waste site locations for the disposal, storage, and handling of solid and hazardous waste...

  3. Bacteriophages as vehicles for gene delivery into mammalian cells: prospects and problems.

    Science.gov (United States)

    Bakhshinejad, Babak; Sadeghizadeh, Majid

    2014-10-01

    The identification of more efficient gene delivery vehicles (GDVs) is essential to fulfill the expectations of clinical gene therapy. Bacteriophages, due to their excellent safety profile, extreme stability under a variety of harsh environmental conditions and the capability for being genetically manipulated, have drawn a flurry of interest to be applied as a newly arisen category of gene delivery platforms. The incessant evolutionary interaction of bacteriophages with human cells has turned them into a part of our body's natural ecosystem. However, these carriers represent several barriers to gene transduction of mammalian cells. The lack of evolvement of specialized machinery for targeted cellular internalization, endosomal, lysosomal and proteasomal escape, cytoplasmic entry, nuclear localization and intranuclear transcription poses major challenges to the expression of the phage-carried gene. In this review, we describe pros and cons of bacteriophages as GDVs, provide an insight into numerous barriers that bacteriophages face for entry into and subsequent trafficking inside mammalian cells and elaborate on the strategies used to bypass these barriers. Tremendous genetic flexibility of bacteriophages to undergo numerous surface modifications through phage display technology has proven to be a turning point in the uncompromising efforts to surmount the limitations of phage-mediated gene expression. The revelatory outcomes of the studies undertaken within the recent years have been promising for phage-mediated gene delivery to move from concept to reality.

  4. Hamburgian weapon delivery technology: a quantitative comparative approach

    DEFF Research Database (Denmark)

    Riede, Felix

    2010-01-01

    The pioneer human re-colonisation of Southern Scandinavia after the Last Ice Age began some time around 12,700 calendar years BC and is associated with the Hamburgian techno-complex. These groups were reindeer hunters whose hunting weapons were tipped with the eponymous shouldered points (pointes á...... cran). Numerous studies have addressed the question of whether these points tipped arrows fired from bows, darts launched with the help of spear-throwers, or some other projectile delivery weapon. This paper approaches the question of Hamburgian weapon delivery technology from a quantitative...... comparative angle. Lithic metric data as well as information on presumed Hamburgian projectile shafts are used to demonstrate that the bow-and-arrow was the most likely weapon delivery method. This is reflected in the shape similarity with both later prehistoric arrow-points and shafts of the Ahrensburgian...

  5. Topical ocular delivery of fluoroquinolones.

    Science.gov (United States)

    Pawar, Pravin; Katara, Rajesh; Mishra, Sushil; Majumdar, Dipak K

    2013-05-01

    Topical fluoroquinolones are used in ophthalmology to treat ocular infections. They are bactericidal and inhibit bacterial DNA replication by inhibiting DNA gyrase and topoisomerase. Fluoroquinolones possess two ionizable groups: a carboxylic group (pKa1 = 5.5 - 6.34) and a heterocyclic group (pKa2 = 7.6 - 9.3), in the nucleus, which acquire charge at pH above and below the isoelectric point (pI = 6.75 - 7.78). At isoelectric point, fluoroquinolones remain unionized and show enhanced corneal penetration but exhibit reduced aqueous solubility and the drug may precipitate from aqueous solution. Aqueous ophthalmic solutions of fluoroquinolones are obtained by using hydrochloride or mesylate salt which is acidic and irritating to the eyes. Hence, pH of the solution is kept between 5 and 7 to ensure aqueous solubility and minimum ocular irritation. This review gives an overview of various physicochemical and formulation factors affecting the ocular delivery of fluoroquinolones and strategies for getting higher ocular bioavailability for ocular delivery of fluoroquinolones. These strategies could be employed to improve efficacy of fluoroquinolones in eye preparation. Broad-spectrum antibacterials, such as the ophthalmic fluoroquinolones, are powerful weapons for treating and preventing potentially sight-threatening infections. The fourth-generation fluoroquinolones have quickly assumed an outstanding place in the ophthalmic applications. Especially valuable for their broad-spectrum coverage against Gram-positive and Gram-negative organisms, these agents have become the anti-infective of preference for many ophthalmologists. Moxifloxacin seems to be a promising powerful molecule among all fluoroquinolones for treatment of bacterial infections.

  6. Global Delivery Models

    DEFF Research Database (Denmark)

    Manning, Stephan; Møller Larsen, Marcus; Bharati, Pratyush M.

    2015-01-01

    Global delivery models (GDMs) are transforming the global IT and business process outsourcing industry. GDMs are a new form of client-specific investment promoting service integration with clients by combining client proximity with time-zone spread for 24/7 service operations. We investigate...... antecedents and contingencies of setting up GDM structures. Based on comprehensive data we show that providers are likely to establish GDM location configurations when clients value access to globally distributed talent and speed of service delivery, in particular when services are highly commoditized...

  7. Ethical issues in cesarean delivery.

    Science.gov (United States)

    Chervenak, Frank A; McCullough, Laurence B

    2017-08-01

    Cesarean delivery is the most common and important surgical intervention in obstetric practice. Ethics provides essential guidance to obstetricians for offering, recommending, recommending against, and performing cesarean delivery. This chapter provides an ethical framework based on the professional responsibility model of obstetric ethics. This framework is then used to address two especially ethically challenging clinical topics in cesarean delivery: patient-choice cesarean delivery and trial of labor after cesarean delivery. This chapter emphasizes a preventive ethics approach, designed to prevent ethical conflict in clinical practice. To achieve this goal, a preventive ethics approach uses the informed consent process to offer cesarean delivery as a medically reasonable alternative to vaginal delivery, to recommend cesarean delivery, and to recommend against cesarean delivery. The limited role of shared decision making is also described. The professional responsibility model of obstetric ethics guides this multi-faceted preventive ethics approach. Copyright © 2017. Published by Elsevier Ltd.

  8. Comparison of SAGS I vs. SAGS II delivery systems in emerging implantation technologies

    Science.gov (United States)

    Despres, Joseph; Sweeney, Joseph

    2012-11-01

    The International Fire Code has classified Subatmospheric Gas Delivery Systems (SAGS) technologies into two main categories: SAGS Type I and SAGS Type II systems. SAGS Type I delivery systems both store and deliver gases at subatmospheric pressures. An example of this technology is ATMI's Safe Delivery Source (SDS®) adsorbent based cylinder. SAGS Type II delivery systems store fluids at high pressure and utilize mechanical devices internal to the cylinder to deliver the gas at subatmospheric pressures. Typical mechanical devices used to enable subatmospheric delivery are either set point regulators or mechanical capillary based systems. This paper focuses on how these delivery systems perform against the unique requirements of traditional beam line ion implantation as well as solar and flat panel applications. Specifically, data are provided showing the capability of these systems with respect to flow rate, residual gas left within the cylinder, and cylinder end-point flow and delivery pressure dynamics.

  9. Corporate environmental management

    DEFF Research Database (Denmark)

    Madsen, Henning; Ulhøi, John Parm

    With increasing population and economic growth and related demand for energy and natural resources as well, pollution, waste production and environmental sustainability have become issues of uttermost importance. For quite some time self-regulation, i.e. voluntary implementation of environmental......: how does industry respond to the environmental challenge? The paper concludes that despite the apparent attractiveness of self-regulation in industry, voluntary options tend not to be widely adopted thus pointing to a continued strong need for an effective regulation of industry’s environmental...

  10. [Complications of cesarean deliveries].

    Science.gov (United States)

    Valgeirsdottir, Heiddis; Hardardottir, Hildur; Bjarnadottir, Ragnheidur I

    2010-01-01

    The objective of the study was to determine the rate of complications which accompany cesarean sections at Landspitali University Hospital (LSH). All deliveries by cesarean section from July 1st 2001 to December 31st 2002 were examined in a retrospective manner. Information was collected from maternity records regarding the operation and its complications if they occurred, during or following the operation. During this period 761 women delivered by cesarean section at LSH. The overall complication rate was 35,5%. The most common complications were; blood loss > or =1000 ml (16.5%), post operative fever (12.2%), extension from the uterine incision (7.2%) and need for blood transfusion (4.3%). Blood transfusion was most common in women undergoing cesarean section after attempted instrumental vaginal delivery (20%). Fever and extension from the uterine incision were most common in women undergoing cesarean section after full cervical dilation without attempt of instrumental delivery (19,4%). These complications were least likely to occur if the patient underwent an elective cesarean section. Complications following cesarean section are common, especially if labor is advanced. Each indication for an operative delivery should be carefully weighed and the patient informed accordingly.

  11. A Medical Delivery Device

    DEFF Research Database (Denmark)

    2010-01-01

    The present invention relates to a medical delivery device comprising at least two membrane electrode assembly units each of which comprises three layers: an upper and a lower electrode and a selective ionic conductive membrane provided there-between. At least one of the three layers are shared...

  12. Recovering from Delivery

    Science.gov (United States)

    ... suicidal thoughts, or any thoughts of harming your baby While recovering from delivery can be a lot to handle, things will get easier. Before you know it, you will be able to fully focus on enjoying your new baby. Reviewed by: Larissa Hirsch, MD Date reviewed: June ...

  13. A Medical Delivery Device

    DEFF Research Database (Denmark)

    2010-01-01

    The present invention relates to a medical delivery device comprising at least two membrane electrode assembly units each of which comprises three layers: an upper and a lower electrode and a selective ionic conductive membrane provided there-between. At least one of the three layers are shared...

  14. Self-nanoemulsifying drug delivery systems for oral insulin delivery

    DEFF Research Database (Denmark)

    Li, Ping; Tan, Angel; Prestidge, Clive A

    2014-01-01

    This study aims at evaluating the combination of self-nanoemulsifying drug delivery systems (SNEDDS) and enteric-coated capsules as a potential delivery strategy for oral delivery of insulin. The SNEDDS preconcentrates, loaded with insulin-phospholipid complex at different levels (0, 2.5 and 10% w...

  15. Nanotopography applications in drug delivery

    Science.gov (United States)

    Walsh, Laura A; Allen, Jessica L; Desai, Tejal A

    2016-01-01

    Refinement of micro- and nanofabrication in the semiconductor field has led to innovations in biomedical technologies. Nanotopography, in particular, shows great potential in facilitating drug delivery. The flexibility of fabrication techniques has created a diverse array of topographies that have been developed for drug delivery applications. Nanowires and nanostraws deliver drug cytosolically for in vitro and ex vivo applications. In vivo drug delivery is limited by the barrier function of the epithelium. Nanowires on microspheres increase adhesion and residence time for oral drug delivery, while also increasing permeability of the epithelium. Low aspect ratio nanocolumns increase paracellular permeability, and in conjunction with microneedles increase transdermal drug delivery of biologics in vivo. In summary, nanotopography is a versatile tool for drug delivery. It can deliver directly to cells or be used for in vivo delivery across epithelial barriers. This editorial highlights the application of nanotopography in the field of drug delivery. PMID:26512871

  16. Optimizing drugs for local delivery.

    Science.gov (United States)

    Collingwood, S; Lock, R; Searcey, M

    2009-12-01

    An international panel of speakers together with approximately 70 delegates were brought together by The Society for Medicines Research's symposium on Optimising Drugs for Local Delivery, held on June 11, 2009 at the Novartis Institutes for Biomedical Research, Horsham, UK. The focus of the conference was on the delivery of drugs direct to the site of action and the consequences of this delivery route on delivery technologies, formulation science and molecular design.

  17. Microprocessor controlled transdermal drug delivery.

    Science.gov (United States)

    Subramony, J Anand; Sharma, Ashutosh; Phipps, J B

    2006-07-06

    Transdermal drug delivery via iontophoresis is reviewed with special focus on the delivery of lidocaine for local anesthesia and fentanyl for patient controlled acute therapy such as postoperative pain. The role of the microprocessor controller in achieving dosimetry, alternating/reverse polarity, pre-programmed, and sensor-based delivery is highlighted. Unique features such as the use of tactile signaling, telemetry control, and pulsatile waveforms in iontophoretic drug delivery are described briefly.

  18. MEMS: Enabled Drug Delivery Systems.

    Science.gov (United States)

    Cobo, Angelica; Sheybani, Roya; Meng, Ellis

    2015-05-01

    Drug delivery systems play a crucial role in the treatment and management of medical conditions. Microelectromechanical systems (MEMS) technologies have allowed the development of advanced miniaturized devices for medical and biological applications. This Review presents the use of MEMS technologies to produce drug delivery devices detailing the delivery mechanisms, device formats employed, and various biomedical applications. The integration of dosing control systems, examples of commercially available microtechnology-enabled drug delivery devices, remaining challenges, and future outlook are also discussed.

  19. GIS-based Mine Tailings Yield Mapping using RUSLE and Sediment Delivery Ratio

    Science.gov (United States)

    Kim, S.; Choi, Y.; Park, H.; Kwon, H.; Yoon, S.; Go, W.

    2010-12-01

    Erosion of mine tailings heaped up on the side of abandoned mine is an environmental problem because they contain harmful heavy metals. These harmful heavy metals such as copper, lead, arsenic in mine tailings cause contamination of surrounding streams and soil. To prevent and reduce the damage of surrounding streams caused by harmful heavy metals leaking from mine tailings, evaluating the pollution loading amount of mine tailings is required. However, it is difficult to assess its environmental impacts accurately because of its complex processes associated with it (Lal 1994). To estimate soil erosion and develop soil erosion management plans, there are some soil erosion estimation methods. Among these methods, the Revised Universal Soil Loss Equation (RUSLE) is the most widely used method. The six factors affecting soil loss such as rainfall-runoff erosivity, soil erodibility, slope length and steepness, cover management, and support practice were extracted from the spatial data and measurement data to evaluate average annual soil loss. Applying this model to mine tailings is possible, because mine tailings are regarded as soil. All the sediment generated may not be delivered at the watershed outlet because some of it may be deposited at various locations in the watershed. RUSLE does not consider the sediment delivery ratio to estimate the mine tailings delivered to the downstream point of interest. In this study, three methods are provided to compute the spatially distributed sediment delivery ratios and the results are compared with each other. Geographical Information System (GIS)-based erosion model and sediment delivery model were used to estimate the potential sediment yield from mine tailings in this study. The results achieved in this study can be used as basis data to assist mine tailings management and tailings dam installation plan. This work was supported by the Mine Reclamation Corporation funded by the Ministry of Knowledge Economy, Republic of Korea

  20. What Is a Cesarean Delivery?

    Science.gov (United States)

    ... are common complications? What is a high-risk pregnancy? What is labor? What is a cesarean delivery? Other FAQs NICHD Research Information Clinical Trials Resources and Publications What is a cesarean delivery? Skip sharing on social media links Share this: Page Content A cesarean delivery ...

  1. Mucoadhesive drug delivery systems

    Directory of Open Access Journals (Sweden)

    Rahamatullah Shaikh

    2011-01-01

    Full Text Available Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first-pass metabolism. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. This review article aims to provide an overview of the various aspects of mucoadhesion, mucoadhesive materials, factors affecting mucoadhesion, evaluating methods, and finally various mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal.

  2. Social video content delivery

    CERN Document Server

    Wang, Zhi; Zhu, Wenwu

    2016-01-01

    This brief presents new architecture and strategies for distribution of social video content. A primary framework for socially-aware video delivery and a thorough overview of the possible approaches is provided. The book identifies the unique characteristics of socially-aware video access and social content propagation, revealing the design and integration of individual modules that are aimed at enhancing user experience in the social network context. The change in video content generation, propagation, and consumption for online social networks, has significantly challenged the traditional video delivery paradigm. Given the massive amount of user-generated content shared in online social networks, users are now engaged as active participants in the social ecosystem rather than as passive receivers of media content. This revolution is being driven further by the deep penetration of 3G/4G wireless networks and smart mobile devices that are seamlessly integrated with online social networking and media-sharing s...

  3. Pyomyositis after vaginal delivery.

    LENUS (Irish Health Repository)

    Gaughan, Eve

    2011-01-01

    Pyomyositis is a purulent infection of skeletal muscle that arises from haematogenous spread, usually with abscess formation. It can develop after a transient bacteraemia of any cause. This type of infection has never been reported before in the literature after vaginal delivery. A 34-year-old woman had progressive severe pain in the left buttock and thigh and weakness in the left lower limb day 1 post spontaneous vaginal delivery. MRI showed severe oedema of the left gluteus, iliacus, piriformis and adductor muscles of the left thigh and a small fluid collection at the left hip joint. She was diagnosed with pyomyositis. She had fever of 37.9°C immediately postpartum and her risk factors for bacteraemia were a mild IV cannula-associated cellulitis and labour itself. She required prolonged treatment with antibiotics before significant clinical improvement was noted.

  4. Delivery strategies for antiparasitics.

    Science.gov (United States)

    Kayser, Oliver; Kiderlen, Albrecht F

    2003-02-01

    Optimisation of drug carrier systems and drug delivery strategies that take into account the peculiarities of individual infectious agents and diseases are key elements of modern drug development. In the following, different aspects of a rational design for antiparasitic drug formulation will be reviewed, covering delivery systems such as nano- and microparticles, liposomes, emulsions and microemulsions, cochleates and bioadhesive macromolecules. Functional properties for each carrier system will be discussed as well as their therapeutic efficacy for parasitic diseases, including leishmaniasis, human African trypanosomiasis, human cryptosporidiosis, malaria and schistosomiasis. Critical issues for the application of drug carrier systems will be discussed, focusing on biopharmaceutical and pathophysiological parameters such as routes of application, improvement of body distribution and targeting intracellularly persisting pathogens.

  5. Transcutaneous antigen delivery system

    Directory of Open Access Journals (Sweden)

    Mi-Young Lee

    2013-01-01

    Full Text Available Transcutaneous immunization refers to the topical applicationof antigens onto the epidermis. Transcutaneous immunizationtargeting the Langerhans cells of the skin has received muchattention due to its safe, needle-free, and noninvasive antigendelivery. The skin has important immunological functions withunique roles for antigen-presenting cells such as epidermalLangerhans cells and dermal dendritic cells. In recent years,novel vaccine delivery strategies have continually beendeveloped; however, transcutaneous immunization has not yetbeen fully exploited due to the penetration barrier representedby the stratum corneum, which inhibits the transport ofantigens and adjuvants. Herein we review recent achievementsin transcutaneous immunization, focusing on the variousstrategies for the enhancement of antigen delivery andvaccination efficacy. [BMB Reports 2013; 46(1: 17-24

  6. Transdermal Delivery of Proteins

    OpenAIRE

    Kalluri, Haripriya; Banga, Ajay K.

    2011-01-01

    Transdermal delivery of peptides and proteins avoids the disadvantages associated with the invasive parenteral route of administration and other alternative routes such as the pulmonary and nasal routes. Since proteins have a large size and are hydrophilic in nature, they cannot permeate passively across the skin due to the stratum corneum which allows the transport of only small lipophilic drug molecules. Enhancement techniques such as chemical enhancers, iontophoresis, microneedles, electro...

  7. Cloud point extraction and electrothermal atomic absorption spectrometry of Se (IV)-3,3'-Diaminobenzidine for the estimation of trace amounts of Se (IV) and Se (VI) in environmental water samples and total selenium in animal blood and fish tissue samples

    Energy Technology Data Exchange (ETDEWEB)

    Sounderajan, Suvarna; Kumar, G. Kiran [Analytical Chemistry Division, Bhabha Atomic Research Center, Trombay, Mumbai 400 085, Maharashtra (India); Udas, A.C., E-mail: acudas@barc.gov.in [Analytical Chemistry Division, Bhabha Atomic Research Center, Trombay, Mumbai 400 085, Maharashtra (India)

    2010-03-15

    This paper presents a method based on the cloud point extraction for the separation and preconcentration of Se (IV) and Se (VI) in environmental water samples as well as total selenium in animal blood and tissue samples. 3,3'-Diaminobenzidine (DAB) is a selective and sensitive reagent and is known to form an intense yellow compound piazselenol with selenium (IV). When a system consisting of sample, DAB and surfactant Triton X-114 is warmed above the cloud point of the surfactant, it was seen that the DAB-Se (IV) complex gets extracted into the surfactant rich phase while the Se (VI) remains in the aqueous phase. Se (VI) in the sample was reduced to Se (IV) by microwave heating of solution in 4 mol L{sup -1} HCl and total Se was estimated by carrying out the CPE. The quantification of selenium was carried out using ETAAS. The analytical parameters for the quantitative cloud point extraction of the Se-DAB complex were investigated and optimized. The proposed procedure was validated by applying it to the determination of the content of Se in Certified Reference Material BND 701-02. (NPL, India). The detection limit of selenium in environmental water samples was 0.0025 {mu}g L{sup -1} with an enrichment factor of 100. The relative standard deviation (RSD) for ten replicate measurements of 5 {mu}g L{sup -1} was 3.6%. The proposed method was successfully applied to the determination of selenium (IV), (VI) in environmental water samples and determination of total selenium in human blood, SRM-IAEA-A-13 animal blood and SRM-IAEA-407 fish tissue.

  8. Comparing Point Clouds

    Science.gov (United States)

    2004-04-01

    Point clouds are one of the most primitive and fundamental surface representations. A popular source of point clouds are three dimensional shape...acquisition devices such as laser range scanners. Another important field where point clouds are found is in the representation of high-dimensional...framework for comparing manifolds given by point clouds is presented in this paper. The underlying theory is based on Gromov-Hausdorff distances, leading

  9. Environmental Monitoring, Air Quality, Ambient air monitoring sites are geographic point locations with monitoring equipment, and possibly meteorological instruments, that monitor outdoor, near ground level criteria pollutant concentrations., Published in 2011, 1:24000 (1in=2000ft) scale, Florida Department of Environmental Protection.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Environmental Monitoring, Air Quality dataset, published at 1:24000 (1in=2000ft) scale, was produced all or in part from Field Survey/GPS information as of...

  10. IMPROVEMENTS IN THE QUALITY OF COURIER DELIVERY

    Directory of Open Access Journals (Sweden)

    Jacek Karcz

    2016-06-01

    Full Text Available The functioning of courier companies is a vital component of modern trade. E-commerce services are changing the way of shopping. Along with them, also courier services change and become more advance. Customers of courier companies become more aware of quality, which they should expect from supplier of these services. The article presents the result of the research of the effectiveness and the timelines of deliveries realized by one of the terminals of a leading courier operator in Poland. The survey involved 55 courier routes over the course of 10 business days. The author analyses weak points of the supply chain and presents two solutions, which may improve quality of delivery processes.

  11. Impactos ambientais na área de proteção ambiental (APA de Guaratuba, Paraná, BrasilL, sob o ponto de vista de moradores tradicionais / Environmental impacts in the Environmental Protection Area (APA of Guaratuba, State of Paraná, Brazil: the traditional communities point-of-view

    Directory of Open Access Journals (Sweden)

    Raphael Telles Kantek

    2009-08-01

    Full Text Available The present research was carried out in the Environmental Protection Area (APA of Guaratuba,State of Paraná, to analyze the environmental impacts of the APA as assessed by the local traditionalcommunities. Two instruments were used: Geographical Information System (GIS and Discourseof the Collective Subject (DSC. Although the GIS covers more situations that the DSC, results weresimilar. The pressures are complex and the analysis must involve the natural and traditionalcommunities.

  12. Environmental Aesthetics

    DEFF Research Database (Denmark)

    Svabo, Connie; Ekelund, Kathrine

    2015-01-01

    The philosophical subfield environmental aesthetics can contribute to the design of sustainable futures. Environmental aesthetics provides a conceptual framework for understanding the relationship between nature and culture. Current positions in environmental aesthetics are lined out and used...

  13. Environmental Performance

    DEFF Research Database (Denmark)

    Svabo, Connie; Lindelof, Anja Mølle

    from the perspective of time and liveness as experienced in art on environmental performance discussing how environmental performances frame the temporality of the world. The paper engages with contemporary examples of environmental performances from various disciplines (sound, video, television...

  14. Dual Transport Process for Targeted Delivery in Porous Media

    Science.gov (United States)

    Deng, W.; Fan, J.

    2015-12-01

    The targeted delivery in porous media is a promising technology to encapsulate the solute (i.e., the cargo) in colloid-like microcapsules (i.e., the carriers), transport the microcapsules in the targeted location in porous media, and then release the solute. While extensive literatures and applications about the drug delivery in human and animal bodies exist, the targeted delivery using similar delivery carriers in subsurface porous media is not well understood. The dual transport process study is an explorative study for the targeted delivery in porous media. While the colloid transport is dominated by the advection process and the solute transport is dominated by the advection-dispersion, the dual transport process is the process with the first step of carrier transport, which is dominated by advection, and then after the release of cargo, the transport of cargo is dominated by advection-dispersion. By applying the random walk particle tracking (RWPT) approach, we investigate how the carriers transport in porous media and how the cargo release mechanisms affect the cargo distribution for the targeted delivery in various patterns of porous media. The RWPT numerical model will be verified against the experimental results of dual transport process in packed-disk 2D micromodels. The understanding of the mechanism of dual transport process is crucial to achieve the potential applications of targeted delivery in improved oil and gas recovery, CO2 sequestration, environmental remediation, and soil biomediation.

  15. Maximizing Output Power of a Solar Panel via Combination of Sun Tracking and Maximum Power Point Tracking by Fuzzy Controllers

    Directory of Open Access Journals (Sweden)

    Mohsen Taherbaneh

    2010-01-01

    Full Text Available In applications with low-energy conversion efficiency, maximizing the output power improves the efficiency. The maximum output power of a solar panel depends on the environmental conditions and load profile. In this paper, a method based on simultaneous use of two fuzzy controllers is developed in order to maximize the generated output power of a solar panel in a photovoltaic system: fuzzy-based sun tracking and maximum power point tracking. The sun tracking is performed by changing the solar panel orientation in horizontal and vertical directions by two DC motors properly designed. A DC-DC converter is employed to track the solar panel maximum power point. In addition, the proposed system has the capability of the extraction of solar panel I-V curves. Experimental results present that the proposed fuzzy techniques result in increasing of power delivery from the solar panel, causing a reduction in size, weight, and cost of solar panels in photovoltaic systems.

  16. Point by Point: Adding up Motivation

    Science.gov (United States)

    Marchionda, Denise

    2010-01-01

    Students often view their course grades as a mysterious equation of teacher-given grades, teacher-given grace, and some other ethereal components based on luck. However, giving students the power to earn points based on numerous daily/weekly assignments and attendance makes the grading process objective and personal, freeing the instructor to…

  17. Vaginal delivery simulation in the Obstetrics and Gynaecology clerkship.

    Science.gov (United States)

    Nitsche, Joshua; Morris, Dana; Shumard, Kristina; Akoma, Ugochi

    2016-10-01

    Although simulation is now used in other areas of obstetrics and gynaecology, its utility in the training of an uncomplicated vaginal delivery is surprisingly under-explored. Here we describe our experience integrating simulation into the third-year Obstetrics and Gynaecology (OB/GYN) clerkship. In 2013/14, at the start of each 4-week OB/GYN clerkship, each third-year student participated in a 90-minute vaginal delivery simulation session using the Noelle(®) simulator. Upon completion of the clerkship, they were surveyed using a five-point Likert scale questionnaire (1, inferior; 5, superior) to assess self-perceived training adequacy, clinical preparedness and number of deliveries performed during the clerkship. Students who completed the clerkship in 2012/13, before the introduction of the simulation, were also surveyed to serve as a comparison group. Survey scores and number of deliveries performed were compared between the two cohorts of students. The 2013/14 cohort (n = 98) who received simulation training gave their training in vaginal deliveries an average rating of 4.1, versus 2.7 for the 2012/13 cohort that did not receive the simulation (n = 80; p < 0.001). Self-perceived preparedness to perform a vaginal delivery was 4.0 in the 2013/14 cohort, versus 3.0 in the 2012/13 cohort (p < 0.001). There was no difference in the number of deliveries performed between the cohorts. Students that received simulation rated their training adequacy and readiness to perform a vaginal delivery higher than students that did not receive training. Simulation did not increase participation in real-life deliveries. The utility of simulation in the training of an uncomplicated vaginal delivery is under-explored. © 2015 John Wiley & Sons Ltd.

  18. Decision from the Commission of Electricity Regulation (CRE) dated from June 27, 2002 about a disagreement between Semmaris company and Electricite de France, as manager of the public power distribution grid, relative to the conditions of consideration of the multiplicity of delivery points in the contractual system of access to the grid; Decision de la Commission de Regulation de l'Electricite (CRE) en date du 27 juin 2002 sur un different, qui oppose la societe Semmaris a Electricite de France, en tant que gestionnaire du reseau public de distribution d'electricite, relatif aux conditions de prise en compte de la multiplicite des points de livraison dans le dispositif contractuel d'acces au reseau electrique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-06-01

    This document presents the analysis made by the French commission of electricity regulation (CRE) about a disagreement between Semmaris company (Rungis, France) and Electricite de France (EdF) concerning the request by Semmaris for the subscription of a single contract of access to the grid for its 18 supply points instead of 9 contracts as proposed by EdF after acceptation of a partial regrouping of some supply points under the same contracts. After examination of the hearings, the CRE requested EdF to establish non-discriminatory objective criteria for the regrouping of different delivery points in a same contract before making a new examination of the disagreement between Semmaris and EdF. (J.S.)

  19. Environmental indicators for buildings

    DEFF Research Database (Denmark)

    Dammann, Sven

    2004-01-01

    Environmental Indicators for Buildings are studied using two different perspectives: with a technological, environmental scientific departing point and with a social scientific departing point. Different relevant groups in the building sector are identified and analysed, using the Social...... Construction Of Technology theory as a frame for the studies. It is concluded that it is not possible to develop a common set of indicators that all the central actors in the building sector find acceptable - at least not in a near future. Different sets of solutions are, however, outlined in the thesis...

  20. Environmental indicators for buildings

    DEFF Research Database (Denmark)

    Dammann, Sven

    Environmental Indicators for Buildings are studied using two different perspectives: with a technological, environmental scientific departing point and with a social scientific departing point. Different relevant groups in the building sector are identified and analysed, using the Social...... Construction Of Technology theory as a frame for the studies. It is concluded that it is not possible to develop a common set of indicators that all the central actors in the building sector find acceptable - at least not in a near future. Different sets of solutions are, however, outlined in the thesis...

  1. Esthetics in Orthodontics: interest points, reference points and discrepancy points

    Directory of Open Access Journals (Sweden)

    Carlos Alexandre Câmara

    2012-10-01

    Full Text Available It is fundamental for orthodontists and all professionals related with facial, oral and dental esthetics to know how the individuals observe dentofacial structures. Thus, it will be the purpose of this Orthodontic Insight to present and describe the Interest, Reference and Discrepancy. Points With the knowledge and perception of these points it will be easier for orthodontists to create a convergent canal of communication with their patients.É fundamental para os ortodontistas e todos os profissionais que estão envolvidos com a estética facial, bucal e dentária conhecer a forma como os indivíduos observam as estruturas dentofaciais. Sendo assim, será o objetivo desse artigo apresentar e descrever os pontos de Interesse, de Referência e de Discrepância. Com o conhecimento e percepção desses pontos, será mais fácil para os ortodontistas criar canais convergentes de comunicação com os seu pacientes.

  2. Multifunctional Nanoparticles for Drug Delivery Applications Imaging, Targeting, and Delivery

    CERN Document Server

    Prud'homme, Robert

    2012-01-01

    This book clearly demonstrates the progression of nanoparticle therapeutics from basic research to applications. Unlike other books covering nanoparticles used in medical applications, Multifunctional Nanoparticles for Drug Delivery Applications presents the medical challenges that can be reduced or even overcome by recent advances in nanoscale drug delivery. Each chapter highlights recent progress in the design and engineering of select multifunctional nanoparticles with topics covering targeting, imaging, delivery, diagnostics, and therapy.

  3. Metrology for drug delivery.

    Science.gov (United States)

    Lucas, Peter; Klein, Stephan

    2015-08-01

    In various recently published studies, it is argued that there are underestimated risks with infusion technology, i.e., adverse incidents believed to be caused by inadequate administration of the drugs. This is particularly the case for applications involving very low-flow rates, i.e., metrological infrastructure for low-flow rates. Technical challenges such as these were the reason a European research project "Metrology for Drug Delivery" was started in 2011. In this special issue of Biomedical Engineering, the results of that project are discussed.

  4. Optimising stroke volume and oxygen delivery in abdominal aortic surgery

    DEFF Research Database (Denmark)

    Bisgaard, J; Gilsaa, T; Rønholm, E

    2012-01-01

    group, stroke volume was optimised by 250 ml colloid boluses intraoperatively and for the first 6 h post-operatively. The optimisation aimed at an oxygen delivery of 600 ml/min/m(2) in the post-operative period. Haemodynamic data were collected at pre-defined time points, including baseline......BACKGROUND: Post-operative complications after open elective abdominal aortic surgery are common, and individualised goal-directed therapy may improve outcome in high-risk surgery. We hypothesised that individualised goal-directed therapy, targeting stroke volume and oxygen delivery, can reduce......, intraoperatively and post-operatively. Patients were followed up for 30 days. RESULTS: Stroke volume index and oxygen delivery index were both higher in the post-operative period in the intervention group. In this group, 27 of 32 achieved the post-operative oxygen delivery index target vs. 18 of 32 in the control...

  5. Interesting Interest Points

    DEFF Research Database (Denmark)

    Aanæs, Henrik; Dahl, Anders Lindbjerg; Pedersen, Kim Steenstrup

    2012-01-01

    on spatial invariance of interest points under changing acquisition parameters by measuring the spatial recall rate. The scope of this paper is to investigate the performance of a number of existing well-established interest point detection methods. Automatic performance evaluation of interest points is hard......Not all interest points are equally interesting. The most valuable interest points lead to optimal performance of the computer vision method in which they are employed. But a measure of this kind will be dependent on the chosen vision application. We propose a more general performance measure based...... position. The LED illumination provides the option for artificially relighting the scene from a range of light directions. This data set has given us the ability to systematically evaluate the performance of a number of interest point detectors. The highlights of the conclusions are that the fixed scale...

  6. CONTROLLED DRUG DELIVERY THROUGH MICROENCAPSULATION

    Directory of Open Access Journals (Sweden)

    NIKHIL K. SACHAN

    2006-01-01

    Full Text Available An appropriately designed controlled release drug delivery system can be a major advance towards solving problems concerning to the targeting of drug to a specific organ or tissue and controlling the rate of drug delivery to the target site. The development of oral controlled release systems has been a challenge to formulation scientist due to their inability to restrain and localize the system at targeted areas of gastrointestinal tract. Microparticulate drug delivery systems are an interesting and promising option when developing an oral controlled release system. The objective of this paper is to take a closer look at microparticles as drug delivery devices for increasing efficiency of drug delivery, improving the release profile and drug targeting. In order to appreciate the application possibilities of microcapsules in drug delivery, some fundamental aspects are briefly reviewed.

  7. Serial floating point formatter

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, R. D.; Penner, W. A.

    1985-11-12

    A floating point formatter for changing fixed point serial digital data, such as that received by a seismic data acquisition system, is disclosed wherein fixed point serial digital data is received and scaled to remove any bias added by preamplification. The scaled data is shifted a predetermined number of bits and a resulting exponent is calculated. The shifted data signal and corresponding exponent are combined and further scaled to permit stacking the data without exceeding the system capacity.

  8. Geodesics on Point Clouds

    OpenAIRE

    Hongchuan Yu; Zhang, Jian J.; Zheng Jiao

    2014-01-01

    We present a novel framework to compute geodesics on implicit surfaces and point clouds. Our framework consists of three parts, particle based approximate geodesics on implicit surfaces, Cartesian grid based approximate geodesics on point clouds, and geodesic correction. The first two parts can effectively generate approximate geodesics on implicit surfaces and point clouds, respectively. By introducing the geodesic curvature flow, the third part produces smooth and accurate geodesic solution...

  9. Magnetic targeted drug delivery

    Directory of Open Access Journals (Sweden)

    Timothy Wiedmann

    2009-10-01

    Full Text Available Lung cancer is the most common cause of death from cancer in both men and women. Treatment by intravenous or oral administration of chemotherapy agents results in serious and often treatment-limiting side effects. Delivery of drugs directly to the lung by inhalation of an aerosol holds the promise of achieving a higher concentration in the lung with lower blood levels. To further enhance the selective lung deposition, it may be possible to target deposition by using external magnetic fields to direct the delivery of drug coupled to magnetic particles. Moreover, alternating magnetic fields can be used to induce particle heating, which in turn controls the drug release rate with the appropriate thermal sensitive material.With this goal, superparamagetic nanoparticles (SPNP were prepared and characterized, and enhanced magnetic deposition was demonstrated in vitro and in vivo. SPNPs were also incorporated into a lipid-based/SPNP aerosol formulation, and drug release was shown to be controlled by thermal activation. Because of the inherent imaging potential of SPNPs, this use of nanotechnology offers the possibility of coupling the diagnosis of lung cancer to drug release, which perhaps will ultimately provide the “magic bullet” that Paul Ehrlich originally sought.

  10. Optimizing multimedia content delivery over next-generation optical networks

    OpenAIRE

    Di Pascale, Emanuele

    2015-01-01

    This thesis analyzes the performance of a Peer-to-Peer (P2P) multimedia content delivery system for a network architecture based on next-generation Passive Optical Networks (PONs). A PON is an optical access technology that is able to deliver high bandwidth capacities at a fraction of the cost of traditional point-to-point fiber solutions; this is achieved by sharing the same feeder fiber among several customers through the use of optical splitters. Established standards such as G...

  11. Document delivery services contrasting views

    CERN Document Server

    1999-01-01

    Design and maintain document delivery services that are ideal for academic patrons! In Document Delivery Services: Contrasting Views, you'll visit four university library systems to discover the considerations and challenges each library faced in bringing document delivery to its clientele. This book examines the questions about document delivery that are most pressing in the profession of library science. Despite their own unique experiences, you'll find common practices among all four?including planning, implementation of service, and evaluation of either user satisfaction and/or vendor per

  12. Methods and metrics challenges of delivery-system research

    Directory of Open Access Journals (Sweden)

    Alexander Jeffrey A

    2012-03-01

    Full Text Available Abstract Background Many delivery-system interventions are fundamentally about change in social systems (both planned and unplanned. This systems perspective raises a number of methodological challenges for studying the effects of delivery-system change--particularly for answering questions related to whether the change will work under different conditions and how the change is integrated (or not into the operating context of the delivery system. Methods The purpose of this paper is to describe the methodological and measurement challenges posed by five key issues in delivery-system research: (1 modeling intervention context; (2 measuring readiness for change; (3 assessing intervention fidelity and sustainability; (4 assessing complex, multicomponent interventions; and (5 incorporating time in delivery-system models to discuss recommendations for addressing these issues. For each issue, we provide recommendations for how research may be designed and implemented to overcome these challenges. Results and conclusions We suggest that a more refined understanding of the mechanisms underlying delivery-system interventions (treatment theory and the ways in which outcomes for different classes of individuals change over time are fundamental starting points for capturing the heterogeneity in samples of individuals exposed to delivery-system interventions. To support the research recommendations outlined in this paper and to advance understanding of the "why" and "how" questions of delivery-system change and their effects, funding agencies should consider supporting studies with larger organizational sample sizes; longer duration; and nontraditional, mixed-methods designs. A version of this paper was prepared under contract with the Agency for Healthcare Research and Quality (AHRQ, US Department of Health and Human Services for presentation and discussion at a meeting on "The Challenge and Promise of Delivery System Research," held in Sterling, VA, on

  13. The Lagrangian points

    Science.gov (United States)

    Linton, J. Oliver

    2017-03-01

    There are five unique points in a star/planet system where a satellite can be placed whose orbital period is equal to that of the planet. Simple methods for calculating the positions of these points, or at least justifying their existence, are developed.

  14. Model Breaking Points Conceptualized

    Science.gov (United States)

    Vig, Rozy; Murray, Eileen; Star, Jon R.

    2014-01-01

    Current curriculum initiatives (e.g., National Governors Association Center for Best Practices and Council of Chief State School Officers 2010) advocate that models be used in the mathematics classroom. However, despite their apparent promise, there comes a point when models break, a point in the mathematical problem space where the model cannot,…

  15. Sunspot Bright Points

    CERN Document Server

    Choudhary, Debi Prasad

    2010-01-01

    We used the flux calibrated images through the Broad Band Filter Imager and Stokes Polarimeter data obtained with the Solar Optical Telescope onboard the Hinode spacecraft to study the properties of bright points in and around the sunspots. The well isolated bright points were selected and classified as umbral dot, peripheral umbral dot, penumbral grains and G-band bright point depending on their location. Most of the bright points are smaller than about 150 km. The larger points are mostly associated with the penumbral features. The bright points are not uniformly distributed over the umbra but preferentially located around the penumbral boundary and in the fast decaying parts of umbra. The color temperature of the bright points, derived using the continuum irradiance, are in the range of 4600 K to 6600 K with cooler ones located in the umbra. The temperature increases as a function of distance from the center to outside. The G-band, CN-band and CaII H flux of the bright points as a function of their blue ba...

  16. Nickel Curie Point Engine

    Science.gov (United States)

    Chiaverina, Chris; Lisensky, George

    2014-01-01

    Ferromagnetic materials such as nickel, iron, or cobalt lose the electron alignment that makes them attracted to a magnet when sufficient thermal energy is added. The temperature at which this change occurs is called the "Curie temperature," or "Curie point." Nickel has a Curie point of 627 K, so a candle flame is a sufficient…

  17. Model Breaking Points Conceptualized

    Science.gov (United States)

    Vig, Rozy; Murray, Eileen; Star, Jon R.

    2014-01-01

    Current curriculum initiatives (e.g., National Governors Association Center for Best Practices and Council of Chief State School Officers 2010) advocate that models be used in the mathematics classroom. However, despite their apparent promise, there comes a point when models break, a point in the mathematical problem space where the model cannot,…

  18. Environmental Denial

    Directory of Open Access Journals (Sweden)

    Tomaž Grušovnik

    2013-03-01

    Full Text Available Even though today reliable information about the negative impact of humans on the environment is only two clicks away, a considerable number of people still deny it. Why? Research shows that what we might call 'environmental denial' is a consequence of specific social and psychological factors: if we were to admit the negative impact of our lifestyles on the environment, we would have to change our way of life founded on consumerism. However, consumerism is not simply a way of exchanging goods; it is also something around which we organize the meaning of our lives, as consumer research clearly shows. Therefore we deny the information on the negattive impact of human activity on the environment because admitting it would lead to a conflict between cognition (attitudes, beliefs and actions (behaviour around which we organize the meaning of our lives. Such an exposition points to wider sociopolitical effects. Firstly, it raises questions about education that have to take into account the non-rational nature of human beings, and secondly it raises questions about the directions and possible outcomes of social action.

  19. Constitutionalization of environmental law

    Directory of Open Access Journals (Sweden)

    Luis Huerta Guerrero

    2013-12-01

    Full Text Available This article analyzes how Environmental Law can take intoconsideration some of fundamental rights study categories, by a constitutional point of view, particularly the right to a balanced and appropriate environment recognized in article 2, paragraph 22 of the 1993 Peruvian Constitution in order to develop policies oriented to implementation of constitutional legal status for environment rights and property.

  20. Environmentally friendly and biobased lubricants

    Science.gov (United States)

    Biobased and environmentally friendly lubricants are finding applications in many areas ranging from hydraulic fluids to grease. They offer excellent biodegradability and very low ecotoxicity; high viscosity index; improved tribological properties; lower volatility and flash points relative to petro...

  1. Gestation length, mode of delivery, and neonatal line-thickness variation.

    Science.gov (United States)

    Zanolli, Clément; Bondioli, Luca; Manni, Franz; Rossi, Paola; Macchiarelli, Roberto

    2011-12-01

    The transition from an intra- to extra-uterine environment leaves its mark in deciduous teeth (and first permanent molars) as an accentuated enamel incremental ring called the neonatal line (NL). This prominent microfeature separates the enamel formed during intrauterine life from that formed after leaving the womb. However, while the physical structure of this scar is well known, the bases of its formation are still a matter of investigation. In particular, besides the influence of the birth-related abrupt environmental and dietary changes and the role played by physiological factors such as hypocalcaemia, a direct relationship between NL thickness variation and the physical was trauma implied by the birth dynamics, the Caesarean, and the operative modes are apparently associated with the thinnest and the thickest lines, respectively. By using the histological record from a deciduous dental sample (exfoliated crowns) of 100 modern healthy school-aged children (47 males and 53 females) of reported birth histories (normal delivery mode: 55 cases; Caesarean: 40; operative: 5), we investigated the relationships between birth dynamics and NL thickness variation. The Tukey Honest Significant Difference method was used to test the differences between the means of the grouping levels. The results of our histo-morphological investigation do not support the suggestion that Caesarean-born children display, on average, a thinner enamel scar compared to children associated to a normal delivery mode. Rather, our study points to the influence exerted by factors intimately related to gestational length variation on the degree of expression of the line.

  2. Holographic Three point Functions

    DEFF Research Database (Denmark)

    Bissi, Agnese

    In this thesis it is addressed the problem of the computation of three point correlation functions within the AdS=CFT correspondence. In the context of the AdS 5=CFT4 correspondence we present three computations. First we compare the results of tree level three point functions of two giant...... gravitons and a point like graviton and its dual counterpart, namely two Schur polynomials and a single trace chiral primary. Secondly we compute the one loop correction to planar, non extremal three point functions of two heavy and one light operators, both from the gauge and string side in the Frolov......-Tseytlin regime. Finally we generalize the scalar product of two states belonging to the SO(6) sector of N = 4 SYM with implications on the construction of three point functions of 3 non-BPS operators from the gauge theory side. On the other hand in the AdS4=CFT3 correspondence we compare the computations...

  3. Multispectral Image Feature Points

    Directory of Open Access Journals (Sweden)

    Cristhian Aguilera

    2012-09-01

    Full Text Available This paper presents a novel feature point descriptor for the multispectral image case: Far-Infrared and Visible Spectrum images. It allows matching interest points on images of the same scene but acquired in different spectral bands. Initially, points of interest are detected on both images through a SIFT-like based scale space representation. Then, these points are characterized using an Edge Oriented Histogram (EOH descriptor. Finally, points of interest from multispectral images are matched by finding nearest couples using the information from the descriptor. The provided experimental results and comparisons with similar methods show both the validity of the proposed approach as well as the improvements it offers with respect to the current state-of-the-art.

  4. Holographic Three point Functions

    DEFF Research Database (Denmark)

    Bissi, Agnese

    In this thesis it is addressed the problem of the computation of three point correlation functions within the AdS=CFT correspondence. In the context of the AdS 5=CFT4 correspondence we present three computations. First we compare the results of tree level three point functions of two giant...... gravitons and a point like graviton and its dual counterpart, namely two Schur polynomials and a single trace chiral primary. Secondly we compute the one loop correction to planar, non extremal three point functions of two heavy and one light operators, both from the gauge and string side in the Frolov......-Tseytlin regime. Finally we generalize the scalar product of two states belonging to the SO(6) sector of N = 4 SYM with implications on the construction of three point functions of 3 non-BPS operators from the gauge theory side. On the other hand in the AdS4=CFT3 correspondence we compare the computations...

  5. Publication point indicators

    DEFF Research Database (Denmark)

    Elleby, Anita; Ingwersen, Peter

    2010-01-01

    with novel publication point indicators (PPIs) that are formalized and exemplified. Two diachronic citation windows are applied: 2006-07 and 2006-08. Web of Science (WoS) as well as Google Scholar (GS) are applied to observe the cite delay and citedness for the different document types published by DIIS......The paper presents comparative analyses of two publication point systems, The Norwegian and the in-house system from the interdiscplinary Danish Institute for International Studies (DIIS), used as case in the study for publications published 2006, and compares central citation-based indicators......; the Cumulated Publication Point Indicator (CPPI), which graphically illustrates the cumulated gain of obtained vs. ideal points, both seen as vectors; and the normalized Cumulated Publication Point Index (nCPPI) that represents the cumulated gain of publication success as index values, either graphically...

  6. Environmental Participation and Environmental Motivation

    OpenAIRE

    Torgler, Benno; María A. García Valiñas; Macintyre, Alison

    2009-01-01

    We explore whether environmental motivation affects environmental behavior by focusing on volunteering. The paper first introduces a theoretical model of volunteering in environmental organizations. In a next step, it tests the hypothesis working with a large micro data set covering 32 countries from both Western and Eastern Europe using several different proxies to measure environmental motivation. Our results indicate that environmental motivation has a strong impact on individuals? volunta...

  7. Elastin-like recombinamers as smart drug delivery systems.

    Science.gov (United States)

    Javier Arias, F; Santos, Mercedes; Ibáñez-Fonseca, Arturo; Piña, Maria Jesús; Serrano, Sofía

    2016-01-31

    Drug delivery systems that are able to control site and rate release of bioactive molecules are of particular interest for tissue therapy. Systems comprising biocompatible materials that can respond to environmental stimuli include elastin-like recombinamers (ELRs), a class of proteinaceous polymers bioinspired by natural elastin, which are especially useful as advanced drug delivery systems in the biomedical field. This review brings together information concerning different versions of ELR-based delivery systems that allow targeted delivery. ELR-drug systems in their monomeric form as well as drug encapsulation by nanoparticle-forming ELRs will be reviewed, focusing later on these drug carriers in which smart release is triggered by pH or temperature with a particular interest on cancer treatments. Systems for controlled drug release based on depots and hydrogels that act both as a support and reservoir in which drugs can be stored will be described, and their applications in drug delivery discussed. Finally, smart drug-delivery systems not based on ELRs, including those comprising proteins, synthetic polymers and non-polymeric systems, will also be briefly discussed.

  8. Rhythmomimetic drug delivery

    CERN Document Server

    Calderer, M Carme; Siegel, Ronald A; Yao, Lingxing

    2015-01-01

    We present modeling, analysis and numerical simulation of a prototype glucose driven drug delivery device based on chemomechanical interactions and volume phase transitions in polyelectrolyte gels. The device consists of two fluid compartments, an external cell (I) mimicking the physiological environment, and a closed chamber (II), separated by a hydrogel membrane. Cell I, which is held at constant pH and ionic strength, provides a constant supply of glucose to cell II, and also serves as clearance station for reaction products. Cell II contains the drug to be delivered to the body, an enzyme that catalyzes conversion of glucose into hydrogen ions, and a piece of marble to remove excess hydrogen ions that would otherwise overwhelm the system. When the membrane is swollen, glucose flux into Cell II is high, leading to rapid production of hydrogen ions. However, the hydrogen ions are not immediately released to Cell I but react, instead, with the negatively charged carboxyl groups of the membrane, which collaps...

  9. Drug delivery goes supercritical

    Directory of Open Access Journals (Sweden)

    Patrick J. Ginty

    2005-08-01

    Full Text Available In the field of drug delivery, the ability to control the size, morphology, and release of drug particles is fundamental to good targeting, but is often hampered by harsh processing conditions or inadequate methods; likewise for the processing of polymeric controlled-release systems. However, the use of supercritical fluids such as supercritical CO2 (scCO2 has provided a ‘clean’ and effective alternative to traditional methods of drug and polymer processing. In particular, scCO2 has a number of unique properties that make it possible to process both bioactive molecules and amorphous polymers without using toxic organic solvents or elevated temperatures. Here, we review the positive impact that supercritical fluids have had on the micronization, encapsulation, and impregnation of molecules of interest to both the pharmaceutical and biotechnology industries.

  10. Environmental strategy

    DEFF Research Database (Denmark)

    Zabkar, Vesna; Cater, Tomaz; Bajde, Domen

    2013-01-01

    Environmental issues and the inclusion of environmental strategies in strategic thinking is an interesting subject of investigation. In general, managerial practices organized along ecologically sound principles contribute to a more environmentally sustainable global economy. From the managerial...... perspective, appropriate environmental strategies in compliance with environmental requirements aim at building competitive advantages through sustainable development. There is no universal “green” strategy that would be appropriate for each company, regardless of its market requirements and competitive...... situations. Instead, managers undertake careful consideration of the circumstances in which their company operates, paying special attention to their customers’ environmental preferences....

  11. Critical Points of Contact

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Morelli, Nicola

    2011-01-01

    In contemporary urban societies multiple networks and systems interact, overlap, exist in parallel, converge, conflict etc. creating unforeseen complexity and less transparency. By exploring how layered networks of physical movement, service information, goods delivery, commercial communication etc...... design, geography, and mobility studies. After the introduction in section we develop and define the notion of CPC based upon a broad set of disciplines and theories. We illustrate the usefulness of the notion within the field of mobility in the network city and within the field of service design...

  12. Hydrogen Delivery Technical Team Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-01

    The mission of the Hydrogen Delivery Technical Team (HDTT) is to enable the development of hydrogen delivery technologies, which will allow for fuel cell competitiveness with gasoline and hybrid technologies by achieving an as-produced, delivered, and dispensed hydrogen cost of $2-$4 per gallon of gasoline equivalent of hydrogen.

  13. Decationized polyplexes for gene delivery

    NARCIS (Netherlands)

    Novo, L.; Mastrobattista, E.; Nostrum, van C.F.; Lammers, T.G.G.M.; Hennink, W.E.

    2015-01-01

    Gene therapy has received much attention in the field of drug delivery. Synthetic, nonviral gene delivery systems have gained increasing attention as vectors for gene therapy mainly due to a favorable immunogenicity profile and ease of manufacturing as compared to viral vectors. The great majority o

  14. Chemical Abstracts' Document Delivery Service.

    Science.gov (United States)

    Rollins, Stephen

    1984-01-01

    The Document Delivery Service offered by Chemical Abstracts is described in terms of the DIALORDER option on the Dialog information retrieval system, mail requests, and requests transmitted through OCLC's Interlibrary Loan system. Transmission costs, success rates, delivery rates, and other considerations in utilizing the service are included.…

  15. Birth delivery trauma and malocclusion.

    Science.gov (United States)

    Cattaneo, Ruggero; Monaco, Annalisa; Streni, Oriana; Serafino, Vittorio; Giannoni, Mario

    2005-01-01

    The aim of the investigation was to determine the dynamic of birth delivery and relate to dental occlusion among a group of adult subjects. The group studied was made up of 106 subjects (57 females and 49 males) referred for dental diagnosis and treatment. The average age was 26 with a range 22 to 30 years. In data collection and analysis the following were used as measures: dental occlusion (Angle Class I, II div 1, II div 2 and III) and type of delivery (normal, short, long, caesarean and other). Results showed that among 106 subjects 72 (68%) had malocclusion versus 34 (32%) with normal occlusion; 24 subjects (22.6%) have been normal delivery versus 82 (77.4%) with non-normal delivery. Class I is present in 34 subjects (32%), class II division 1 in 26 (24%), class II division 2 in 22. (20%), class III in 16 (14%), and 8 subjects (6%) fall in the section "other". Among 24 subjects with normal delivery 100% presented class I occlusion. However, among 82 subjects with non-normal delivery 10 subjects had a class I (12.2%) and the 72 (87.8%) had in the other classes, are distributed in the various subgroups of non-normal labor/delivery. None of the subjects with a malocclusion have a normal labor/delivery. Better understanding of the connections among osteopathic theory, craniosacral treatment and the outcomes upon dental occlusion, more rigorous evaluations are warranted.

  16. Do acupuncture points exist?

    Energy Technology Data Exchange (ETDEWEB)

    Yan Xiaohui; Zhang Xinyi [Department of Physics, Surface Physics Laboratory (State Key Laboratory), and Synchrotron Radiation Research Center of Fudan University, Shanghai 200433 (China); Liu Chenglin [Physics Department of Yancheng Teachers' College, Yancheng 224002 (China); Dang, Ruishan [Second Military Medical University, Shanghai 200433 (China); Huang Yuying; He Wei [Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100039 (China); Ding Guanghong [Shanghai Research Center of Acupuncture and Meridian, Pudong, Shanghai 201203 (China)

    2009-05-07

    We used synchrotron x-ray fluorescence analysis to probe the distribution of four chemical elements in and around acupuncture points, two located in the forearm and two in the lower leg. Three of the four acupuncture points showed significantly elevated concentrations of elements Ca, Fe, Cu and Zn in relation to levels in the surrounding tissue, with similar elevation ratios for Cu and Fe. The mapped distribution of these elements implies that each acupuncture point seems to be elliptical with the long axis along the meridian. (note)

  17. Children's Environmental Concerns: Expressing Ecophobia

    Science.gov (United States)

    Strife, Susan Jean

    2012-01-01

    While numerous quantitative studies across disciplines have investigated children's knowledge and attitudes about environmental problems, few studies examine children's feelings about environmental problems--and even fewer have focused on the child's point of view. Through 50 in-depth interviews with urban children (ages 10-12) this research aimed…

  18. Designated Wildlife Lakes - points

    Data.gov (United States)

    Minnesota Department of Natural Resources — This is a point shapefile of Designated Wildlife Lakes in Minnesota. This shapefile was created by converting lake polygons from the Designated Wildlife Lakes...

  19. Point/Counterpoint

    DEFF Research Database (Denmark)

    Ungar, David; Ernst, Erik

    2007-01-01

    Point Argument: "Dynamic Languages (in Reactive Environments) Unleash Creativity," by David Ungar. For the sake of creativity, the profession needs to concentrate more on inventing new and better dynamic languages and environments and less on improving static languages. Counterpoint Argument...

  20. Allegheny County Address Points

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset contains address points which represent physical address locations assigned by the Allegheny County addressing authority. Data is updated by County...

  1. Point tenderness - abdomen

    Science.gov (United States)

    ... medlineplus.gov/ency/article/003273.htm Point tenderness - abdomen To use the sharing features on this page, ... over a certain part of the belly area (abdomen). Considerations The abdomen is an area of the ...

  2. National Wetlands Inventory Points

    Data.gov (United States)

    Minnesota Department of Natural Resources — Wetland point features (typically wetlands that are too small to be as area features at the data scale) mapped as part of the National Wetlands Inventory (NWI). The...

  3. Triple Point Topological Metals

    Directory of Open Access Journals (Sweden)

    Ziming Zhu

    2016-07-01

    Full Text Available Topologically protected fermionic quasiparticles appear in metals, where band degeneracies occur at the Fermi level, dictated by the band structure topology. While in some metals these quasiparticles are direct analogues of elementary fermionic particles of the relativistic quantum field theory, other metals can have symmetries that give rise to quasiparticles, fundamentally different from those known in high-energy physics. Here, we report on a new type of topological quasiparticles—triple point fermions—realized in metals with symmorphic crystal structure, which host crossings of three bands in the vicinity of the Fermi level protected by point group symmetries. We find two topologically different types of triple point fermions, both distinct from any other topological quasiparticles reported to date. We provide examples of existing materials that host triple point fermions of both types and discuss a variety of physical phenomena associated with these quasiparticles, such as the occurrence of topological surface Fermi arcs, transport anomalies, and topological Lifshitz transitions.

  4. Bedrock Outcrop Points Compilation

    Data.gov (United States)

    Vermont Center for Geographic Information — A compilation of bedrock outcrops as points and/or polygons from 1:62,500 and 1:24,000 geologic mapping by the Vermont Geological Survey, the United States...

  5. Transitivity on Weierstrass points

    CERN Document Server

    Laing, Zoe

    2010-01-01

    We look for Riemann surfaces whose automorphism group acts transitively on the Weierstrass points. We concentrate on hyperelliptic surfaces, surfaces with PSL(2, q) as automorphism group, Platonic surfaces and Fermat curves.

  6. Iowa Geologic Sampling Points

    Data.gov (United States)

    Iowa State University GIS Support and Research Facility — Point locations of geologic samples/files in the IGS repository. Types of samples include well cuttings, outcrop samples, cores, drillers logs, measured sections,...

  7. Allegheny County Address Points

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset contains address points which represent physical address locations assigned by the Allegheny County addressing authority. Data is updated by County...

  8. Development of wood fuel delivery logistics; Puupolttoaineiden hankintalogistiikan kehittaeminen

    Energy Technology Data Exchange (ETDEWEB)

    Laitinen, H.

    1996-12-31

    The main aim of the project is to model the energy wood business and total logistics in a certain large region. First, wood utilisation locations inside this area are examined; the most important ones are the wood processing factories, and the heating- and power plants. After that, wood potentials in the forests of the area are evaluated in sub-areas suitable in size and sufficiently detailed for further evaluations. For that purpose, the most valuable source data are forest management plans, up to ten years forward, on which basis the wood fuel potentials can be evaluated following sustainable development. In Finland there are extensive and detailed data bases storing forest information and it is possible to collect necessary data for a data base applicable to our calculations. In logistical sense it is important to know, by which delivery chains the economically best and desired results are achieved. The software prototype based on data base is modelled and developed at VTT Energy, for facilitating these planning activities. The starting point of the planning system in delivery logistics is the implementation of an easy tool for versatile planning so that with this tool model different delivery chains can be flexiblyed, create usage scenarios, make alternative examinations, and calculate impacts of different factors on energy wood amounts yielded and delivery costs. With planning system in delivery logistics we calculate production costs and amounts delivered to different utilisation locations. The system offers tools for definitions of utilisation locations, calculation parameters, and delivery chains

  9. Environmental strategy

    DEFF Research Database (Denmark)

    Zabkar, Vesna; Cater, Tomaz; Bajde, Domen

    2013-01-01

    perspective, appropriate environmental strategies in compliance with environmental requirements aim at building competitive advantages through sustainable development. There is no universal “green” strategy that would be appropriate for each company, regardless of its market requirements and competitive...... situations. Instead, managers undertake careful consideration of the circumstances in which their company operates, paying special attention to their customers’ environmental preferences....

  10. Indexing Moving Points

    DEFF Research Database (Denmark)

    Agarwal, Pankaj K.; Arge, Lars Allan; Erickson, Jeff

    2003-01-01

    also describe an indexing scheme in which the number of I/Os required to answer a query depends monotonically on the difference between the query time stamp t and the current time. Finally, we develop an efficient indexing scheme to answer approximate nearest-neighbor queries among moving points.......We propose three indexing schemes for storing a set S of N points in the plane, each moving along a linear trajectory, so that any query of the following form can be answered quickly: Given a rectangle R and a real value t, report all K points of S that lie inside R at time t. We first present...... an indexing structure that, for any given constant >0, uses O(N/B) disk blocks and answers a query in O((N/B)1/2+ +K/B) I/Os, where B is the block size. It can also report all the points of S that lie inside R during a given time interval. A point can be inserted or deleted, or the trajectory of a point can...

  11. Appropriate technologies for environmental hygiene.

    Science.gov (United States)

    McGarry, M G

    1980-07-28

    Appropriate technologies for environmental hygiene usually centre on the delivery of adequate and accessible water supply, and proper treatment and disposal of excreta and refuse. In the face of the International Drinking Water and Sanitation Decade of 1981-90, several research efforts are under way in the developing countries to develop technologies and approaches for improving environmental hygiene in both rural areas and urban squatter settlements. These are discussed and include the technical development and field testing of infiltration galleries, low-cost slow and fast filtration processes for water treatment, handpumps, on-site excreta disposal using aqua-privy and compost toilets, and excreta treatment and refuse through composting with refuse, biogas generation, fish culture and use of excreta as crop fertilizer. The relevant technology 'hardware' is but one of several components necessary for effective delivery of services. The dearth of qualified manpower at all levels is described as being the major constraint to the Water and Sanitation Decade.

  12. Environmental history

    DEFF Research Database (Denmark)

    Pawson, Eric; Christensen, Andreas Aagaard

    2016-01-01

    Environmental history is an interdisciplinary pursuit that has developed as a form of conscience to counter an increasingly powerful, forward-looking liberal theory of the environment. It deals with the relations between environmental ideas and materialities, from the work of the geographers George...... risks”. These are exposed by environmental history’s focus on long-run analysis and its narrative form that identifies the stories that we tell ourselves about nature. How a better understanding of past environmental transformations helps to analyse society and agency, and what this can mean...... for solutions and policies, is the agenda for an engaged environmental history from now on....

  13. (Environmental technology)

    Energy Technology Data Exchange (ETDEWEB)

    Boston, H.L.

    1990-10-12

    The traveler participated in a conference on environmental technology in Paris, sponsored by the US Embassy-Paris, US Environmental Protection Agency (EPA), the French Environmental Ministry, and others. The traveler sat on a panel for environmental aspects of energy technology and made a presentation on the potential contributions of Oak Ridge National Laboratory (ORNL) to a planned French-American Environmental Technologies Institute in Chattanooga, Tennessee, and Evry, France. This institute would provide opportunities for international cooperation on environmental issues and technology transfer related to environmental protection, monitoring, and restoration at US Department of Energy (DOE) facilities. The traveler also attended the Fourth International Conference on Environmental Contamination in Barcelona. Conference topics included environmental chemistry, land disposal of wastes, treatment of toxic wastes, micropollutants, trace organics, artificial radionuclides in the environment, and the use biomonitoring and biosystems for environmental assessment. The traveler presented a paper on The Fate of Radionuclides in Sewage Sludge Applied to Land.'' Those findings corresponded well with results from studies addressing the fate of fallout radionuclides from the Chernobyl nuclear accident. There was an exchange of new information on a number of topics of interest to DOE waste management and environmental restoration needs.

  14. Preparation of drug delivery systems using supercritical fluid technology.

    Science.gov (United States)

    Kompella, U B; Koushik, K

    2001-01-01

    Small changes in temperature and pressure near the critical region induce dramatic changes in the density and solubility of supercritical fluids, thereby facilitating the use of environmentally benign agents such as CO2 for their solvent and antisolvent properties in processing a wide variety of materials. While supercritical fluid technologies have been in commercial use in the food and chromatography industries for several years, only recently has this technology made inroads in the formulation of drug delivery systems. This review summarizes some of the recent applications of supercritical fluid technology in the preparation of drug delivery systems. Drugs containing polymeric particles, plain drug particles, solute-containing liposomes, and inclusion complexes of drug and carrier have been formulated using this technology. Also, polymer separation using this technology is enabling the selection of a pure fraction of a polymer, thereby allowing a more precise control of drug release from polymeric delivery systems.

  15. Phage Particles as Vaccine Delivery Vehicles: Concepts, Applications and Prospects.

    Science.gov (United States)

    Jafari, Narjes; Abediankenari, Saeid

    2015-01-01

    The development of new strategies for vaccine delivery for generating protective and long-lasting immune responses has become an expanding field of research. In the last years, it has been recognized that bacteriophages have several potential applications in the biotechnology and medical fields because of their intrinsic advantages, such as ease of manipulation and large-scale production. Over the past two decades, bacteriophages have gained special attention as vehicles for protein/peptide or DNA vaccine delivery. In fact, whole phage particles are used as vaccine delivery vehicles to achieve the aim of enhanced immunization. In this strategy, the carried vaccine is protected from environmental damage by phage particles. In this review, phage-based vaccine categories and their development are presented in detail, with discussion of the potential of phage-based vaccines for protection against microbial diseases and cancer treatment. Also reviewed are some recent advances in the field of phage- based vaccines.

  16. Environmental spaces

    DEFF Research Database (Denmark)

    Larsen, Henrik Gutzon

    Using the development of intergovernmental environmental cooperation in the Baltic Sea area as a concrete example, the aim of this study is to explore how the 'environment' in situations of environmental interdependence is identified and institutionalised as political-geographical objects....... 'Environmental interdependence' is to this end conceptualised as a tension between 'political spaces' of discrete state territories and 'environmental spaces' of spatially nested ecosystems. This tension between geographies of political separateness and environmental wholeness is the implicit or explicit basis...... for a large and varied literature. But in both its critical and problemsolving manifestations, this literature tends to naturalise the spatiality of environmental concerns: environmental spaces are generally taken for granted. On the suggestion that there is a subtle politics to the specification...

  17. Cyclodextrins for drug delivery.

    Science.gov (United States)

    Laza-Knoerr, A L; Gref, R; Couvreur, P

    2010-11-01

    Cyclodextrins (CDs) are macrocyclic oligosaccharides composed of α(1,4)-linked glucopyranose subunits. These molecules possess a cage-like supramolecular structure, comparable with the structures of crown ethers, cryptands, spherands, cyclophanes, or calixarenes. However, it took 50 years to establish the molecular structure of CDs. Owing to their capability to form inclusion complexes with a variety of guest molecules, CDs are considered as the most important supramolecular host family among all supramolecular structures mentioned above. They can form complexes with various types of molecules including inorganic, organic, or organometallic that can be radical, cationic, anionic, or neutral molecules. This phenomenon bears the name "molecular recognition," while the selectivity in the formation of complexes with enantiomeric species as guests is called "chiral recognition." In addition, the properties of the molecules forming the complexes with CDs can be modified significantly. As such, a large number of scientists have attempted to elaborate and evaluate various CD derivatives that are able to complex a variety of drugs, enhancing by this way their in vivo solubility and activity. Moreover, a large number of publications describe CD uses in other fields such as foods, textile, cosmetics, or agriculture. This review reports on the recent developments of CDs in drug delivery using various routes of administration.

  18. Delivery technologies for genome editing.

    Science.gov (United States)

    Yin, Hao; Kauffman, Kevin J; Anderson, Daniel G

    2017-03-24

    With the recent development of CRISPR technology, it is becoming increasingly easy to engineer the genome. Genome-editing systems based on CRISPR, as well as transcription activator-like effector nucleases (TALENs) and zinc-finger nucleases (ZFNs), are becoming valuable tools for biomedical research, drug discovery and development, and even gene therapy. However, for each of these systems to effectively enter cells of interest and perform their function, efficient and safe delivery technologies are needed. This Review discusses the principles of biomacromolecule delivery and gene editing, examines recent advances and challenges in non-viral and viral delivery methods, and highlights the status of related clinical trials.

  19. Arctic tipping points

    OpenAIRE

    Smolkova, Valentina

    2015-01-01

    The Arctic is warming much faster than the entire planet, and this causes severe melting of sea ice. However, the climate of different regions of the Earth is interconnected, and changes in the amount of ice in the Arctic can dramatically affect the climate across the whole planet. Some scientists claim that a possible tipping point is the event of the ice-free Arctic Ocean in summer. Certain predictions point towards ice-free Arctic summers around the year 2050, whereas others pre- dict this...

  20. Final Environmental Assessment for High Altitude Mobile Pointing Platform Tests

    Science.gov (United States)

    2006-01-22

    Desert pupfish Cyprinodon Endangered Small (2 inches) smoothly Graham, La Paz, < 5,000 ft Shallow springs, small Critical habitat includes...Quitobaquito macularius rounded body shape with Maricopa, P ima, streams, and marshes Springs, Pima County, portions of San narrow vertical bars on the Pinal...Chaves, De Baca, Eddy. Pecos pupfish Cyprinodon pecosensis Fish Species of Concern Chaves, Eddy. Rio Grande cutthroat trout Oncorhynchus

  1. Continuous Delivery and Quality Monitoring

    CERN Document Server

    CERN. Geneva

    2016-01-01

    After introducing Continuous Delivery, I will switch the topic and try to answer the question how much should we invest in quality and how to do it efficiently. My observations reveal that software quality is often considered as the slo...

  2. The delivery of therapeutic oligonucleotides.

    Science.gov (United States)

    Juliano, Rudolph L

    2016-08-19

    The oligonucleotide therapeutics field has seen remarkable progress over the last few years with the approval of the first antisense drug and with promising developments in late stage clinical trials using siRNA or splice switching oligonucleotides. However, effective delivery of oligonucleotides to their intracellular sites of action remains a major issue. This review will describe the biological basis of oligonucleotide delivery including the nature of various tissue barriers and the mechanisms of cellular uptake and intracellular trafficking of oligonucleotides. It will then examine a variety of current approaches for enhancing the delivery of oligonucleotides. This includes molecular scale targeted ligand-oligonucleotide conjugates, lipid- and polymer-based nanoparticles, antibody conjugates and small molecules that improve oligonucleotide delivery. The merits and liabilities of these approaches will be discussed in the context of the underlying basic biology. © The Author 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  3. Extracellular vesicles for drug delivery

    NARCIS (Netherlands)

    Vader, Pieter; Mol, Emma A; Pasterkamp, Gerard; Schiffelers, Raymond M

    Extracellular vesicles (EVs) are cell-derived membrane vesicles, and represent an endogenous mechanism for intercellular communication. Since the discovery that EVs are capable of functionally transferring biological information, the potential use of EVs as drug delivery vehicles has gained

  4. Oral delivery of anticancer drugs

    DEFF Research Database (Denmark)

    Thanki, Kaushik; Gangwal, Rahul P; Sangamwar, Abhay T

    2013-01-01

    The present report focuses on the various aspects of oral delivery of anticancer drugs. The significance of oral delivery in cancer therapeutics has been highlighted which principally includes improvement in quality of life of patients and reduced health care costs. Subsequently, the challenges...... incurred in the oral delivery of anticancer agents have been especially emphasized. Sincere efforts have been made to compile the various physicochemical properties of anticancer drugs from either literature or predicted in silico via GastroPlus™. The later section of the paper reviews various emerging...... trends to tackle the challenges associated with oral delivery of anticancer drugs. These invariably include efflux transporter based-, functional excipient- and nanocarrier based-approaches. The role of drug nanocrystals and various others such as polymer based- and lipid based...

  5. Microwave Assisted Drug Delivery

    DEFF Research Database (Denmark)

    Jónasson, Sævar Þór; Zhurbenko, Vitaliy; Johansen, Tom Keinicke

    2014-01-01

    In this work, the microwave radiation is adopted for remote activation of pharmaceutical drug capsules inside the human body in order to release drugs at a pre-determined time and location. An array of controllable transmitting sources is used to produce a constructive interference at a certain...... focus point inside the body, where the drugs are then released from the specially designed capsules. An experimental setup for microwave activation has been developed and tested on a body phantom that emulates the human torso. A design of sensitive receiving structures for integration with a drug...

  6. Microwave Assisted Drug Delivery

    DEFF Research Database (Denmark)

    Jónasson, Sævar Þór; Zhurbenko, Vitaliy; Johansen, Tom Keinicke

    2014-01-01

    In this work, the microwave radiation is adopted for remote activation of pharmaceutical drug capsules inside the human body in order to release drugs at a pre-determined time and location. An array of controllable transmitting sources is used to produce a constructive interference at a certain...... focus point inside the body, where the drugs are then released from the specially designed capsules. An experimental setup for microwave activation has been developed and tested on a body phantom that emulates the human torso. A design of sensitive receiving structures for integration with a drug...

  7. Environmental taxes

    DEFF Research Database (Denmark)

    Ekins, P.; Andersen, Mikael Skou; Vos, H.

    & competitiveness; c) employment, and d) the tax system. These are the main conclusions of a report on environmental taxes by the European Environment Agency (EEA), requested by the European Parliament. The report provides an overview of the main issues involved in environmental taxes, with a particular focus......EXECUTIVE SUMMARY1.Although the 5th Environmental Action Programme of the EU in 1992 recommended the greater use of economic instruments such as environmental taxes, there has been little progress in their use since then at the EU level. At Member State level, however, there has been a continuing...... increase in the use of environmental taxes over the last decade, which has accelerated in the last 5-6 years. This is primarily apparent in Scandinavia, but it is also noticeable in Austria, Belgium, France, Germany, The Netherlands and the United Kingdom.2.Evaluation studies of 16 environmental taxes have...

  8. Holographic Three point Functions

    DEFF Research Database (Denmark)

    Martirosyan, Ara

    The main subject of this thesis is the computation of structure constants appearing in the three-point functions for certain type of states/operators in the context of the AdS/CFT correspondence, which is one of the important parts of the dynamical problem in the dual theories of the correspondence...

  9. New Novae snack point

    CERN Multimedia

    2012-01-01

    Located next to the car park by the flag poles, a few metres from the Main CERN Reception (building 33), a new snack point catered by Novae will open to the public on Wednesday 8 August. More information will be available in the next issue of the Bulletin!

  10. Points and Practices

    Science.gov (United States)

    Ahmed, Syed Jamil; Heddon, Dee; Mackey, Sally

    2007-01-01

    This collection of three articles represents the "Points and Practices" section of this month's issue of "Research in Drama Education." The first article, "'Fitting the Bill' for 'Helping Them.' A Response to 'Integrated Popular Theatre Approach in Africa' and 'Commissioned Theatre Projects on Human Rights in…

  11. ACCESS Pointing Control System

    Science.gov (United States)

    Brugarolas, Paul; Alexander, James; Trauger, John; Moody, Dwight; Egerman, Robert; Vallone, Phillip; Elias, Jason; Hejal, Reem; Camelo, Vanessa; Bronowicki, Allen; O'Connor, David; Partrick, Richard; Orzechowski, Pawel; Spitter, Connie; Lillie, Chuck

    2010-01-01

    ACCESS (Actively-Corrected Coronograph for Exoplanet System Studies) was one of four medium-class exoplanet concepts selected for the NASA Astrophysics Strategic Mission Concept Study (ASMCS) program in 2008/2009. The ACCESS study evaluated four major coronograph concepts under a common space observatory. This paper describes the high precision pointing control system (PCS) baselined for this observatory.

  12. Decision Points in Cataloging.

    Science.gov (United States)

    Bright, Franklyn F.

    Libraries are frequently faced with policy decisions which can affect the quality and cost of library services for years to come. This point can be illustrated by citing examples of decisions made at the University of Wisconsin Library in the areas of: (1) conforming to national cataloging standards; (2) producing catalog cards in-house; and (3)…

  13. Points and Practices

    Science.gov (United States)

    Ahmed, Syed Jamil; Heddon, Dee; Mackey, Sally

    2007-01-01

    This collection of three articles represents the "Points and Practices" section of this month's issue of "Research in Drama Education." The first article, "'Fitting the Bill' for 'Helping Them.' A Response to 'Integrated Popular Theatre Approach in Africa' and 'Commissioned Theatre Projects on Human Rights in…

  14. Publication point indicators

    DEFF Research Database (Denmark)

    Elleby, Anita; Ingwersen, Peter

    2010-01-01

    with novel publication point indicators (PPIs) that are formalized and exemplified. Two diachronic citation windows are applied: 2006-07 and 2006-08. Web of Science (WoS) as well as Google Scholar (GS) are applied to observe the cite delay and citedness for the different document types published by DIIS...

  15. Critical Points of Contact

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Morelli, Nicola

    2011-01-01

    where the networks meet and establish contact. Thus we argue for the usefulness of the notion of Critical Point of Contact (CPC) to deepen our understanding of the actual life within networks. En route to this notion we draw upon theories within as diverse realms such as interaction design, service...

  16. Critical Points of Contact

    DEFF Research Database (Denmark)

    2012-01-01

    In this brief article, we shall illustrate the application of the analytical and interventionist concept of ‘Critical Points of Contact’ (CPC) through a number of urban design studios. The notion of CPC has been developed over a span of the last three to four years and is reported in more detail...

  17. Precise Point Positioning

    DEFF Research Database (Denmark)

    Zhang, Xiaohong

    determination’ based on the relationship between the point clouds on regular objects (e.g. flat top buildings) and the ground truth of the objects used for calibration. In order to extract the footprints on the objects, filtering was implemented before the calibration. Three example tests have been made...

  18. Holographic Three point Functions

    DEFF Research Database (Denmark)

    Martirosyan, Ara

    The main subject of this thesis is the computation of structure constants appearing in the three-point functions for certain type of states/operators in the context of the AdS/CFT correspondence, which is one of the important parts of the dynamical problem in the dual theories of the correspondence...

  19. Pro SharePoint 2010 Business Intelligence Solutions

    CERN Document Server

    Malik, Sahil; Wright, Steve

    2010-01-01

    What differentiates good organizations from bad? The good ones are those that take advantage of the data they already have and use the feedback that business intelligence gives them to improve their processes. SharePoint is now the delivery platform of choice for Microsoft's business intelligence products, and in this book we reveal how to get the most from developing business intelligence solutions on SharePoint 2010. To understand the various business intelligence offerings in SharePoint 2010, you need to understand the core SQL Server business intelligence concepts, and the first part of th

  20. Organoclays for drug delivery Systems

    OpenAIRE

    Canovas Creus, Alba

    2008-01-01

    Modified clays can be used as carriers of drugs due to their suitable properties and structure in order to achieve improvements in drug delivery. The study of this thesis starts with an introduction to mineral clays and its classification, properties and characterization, then deepens into modified clays (properties, comparison with mineral clays, applications and procedure of modification). Another chapter is focused in drug delivery: definition, its difficulties nowadays and the different w...

  1. Electroporation-mediated gene delivery.

    Science.gov (United States)

    Young, Jennifer L; Dean, David A

    2015-01-01

    Electroporation has been used extensively to transfer DNA to bacteria, yeast, and mammalian cells in culture for the past 30 years. Over this time, numerous advances have been made, from using fields to facilitate cell fusion, delivery of chemotherapeutic drugs to cells and tissues, and most importantly, gene and drug delivery in living tissues from rodents to man. Electroporation uses electrical fields to transiently destabilize the membrane allowing the entry of normally impermeable macromolecules into the cytoplasm. Surprisingly, at the appropriate field strengths, the application of these fields to tissues results in little, if any, damage or trauma. Indeed, electroporation has even been used successfully in human trials for gene delivery for the treatment of tumors and for vaccine development. Electroporation can lead to between 100 and 1000-fold increases in gene delivery and expression and can also increase both the distribution of cells taking up and expressing the DNA as well as the absolute amount of gene product per cell (likely due to increased delivery of plasmids into each cell). Effective electroporation depends on electric field parameters, electrode design, the tissues and cells being targeted, and the plasmids that are being transferred themselves. Most importantly, there is no single combination of these variables that leads to greatest efficacy in every situation; optimization is required in every new setting. Electroporation-mediated in vivo gene delivery has proven highly effective in vaccine production, transgene expression, enzyme replacement, and control of a variety of cancers. Almost any tissue can be targeted with electroporation, including muscle, skin, heart, liver, lung, and vasculature. This chapter will provide an overview of the theory of electroporation for the delivery of DNA both in individual cells and in tissues and its application for in vivo gene delivery in a number of animal models.

  2. A COMPREHENSIVE REVIEW OF PULSATILE DRUG DELIVERY SYSTEMS

    Directory of Open Access Journals (Sweden)

    Rompicharla Bhargavi

    2012-03-01

    Full Text Available Pulsatile drug delivery systems are gaining popularity in the field of pharmaceutical formulation, research and development. The prime advantage in this drug delivery is that the drug is released as per the pathophysiological need of the disease. As a result the change of development of drug resistance which is seen in conventional and sustained released formulations can be reduced. This therapy is mainly applicable where sustained action is not required and the drugs are toxic. Basic point of development of this formulation is to find out the circadian rhythms that is a suitable indicator that will trigger the release of drug from the device. Clock genes are the genes that control the circadian rhythms in human physiology. Pulsatile drug delivery systems are promising incase of asthma, cardiovascular diseases, peptic ulcers, arthritis, and hypercholesterolemic conditions.

  3. Environmental Tritium

    OpenAIRE

    百島, 則幸

    2000-01-01

    Environmental tritium was first observed in a helium fraction at a liquid air production facility in Germany in 1949. During the 1950s and early 1960s, huge amounts of artificial tritium were released into the atmosphere by nuclear testing. The environmental tritium level increased to more than 200 times the natural tritium level. Since the signing of a test ban treaty in 1963, the environmental tritium level has decreased, and analysis of recent Japanese rain samples has shown that the envir...

  4. Delivery of antibiotics with polymeric particles.

    Science.gov (United States)

    Xiong, Meng-Hua; Bao, Yan; Yang, Xian-Zhu; Zhu, Yan-Hua; Wang, Jun

    2014-11-30

    Despite the wide use of antibiotics, bacterial infection is still one of the leading causes of hospitalization and mortality. The clinical failure of antibiotic therapy is linked with low bioavailability, poor penetration to bacterial infection sites, and the side effects of antibiotics, as well as the antibiotic resistance properties of bacteria. Antibiotics encapsulated in nanoparticles or microparticles made up of a biodegradable polymer have shown great potential in replacing the administration of antibiotics in their "free" form. Polymeric particles provide protection to antibiotics against environmental deactivation and alter antibiotic pharmacokinetics and biodistribution. Polymeric particles can overcome tissue and cellular barriers and deliver antibiotics into very dense tissues and inaccessible target cells. Polymeric particles can be modified to target or respond to particular tissues, cells, and even bacteria, and thereby facilitate the selective concentration or release of the antibiotic at infection sites, respectively. Thus, the delivery of antibiotics with polymeric particles augments the level of the bioactive drug at the site of infection while reducing the dosage and the dosing frequency. The end results are improved therapeutic effects as well as decreased "pill burden" and drug side effects in patients. The main objective of this review is to analyze recent advances and current perspectives in the use of polymeric antibiotic delivery systems in the treatment of bacterial infection.

  5. Transdermal drug delivery system: An overview

    Directory of Open Access Journals (Sweden)

    Vaibhav Rastogi

    2012-01-01

    Full Text Available Transdermal drug delivery system (TDDS is one of the systems lying under the category of controlled drug delivery, in which the aim is to deliver the drug through the skin in a predetermined and controlled rate. It has various advantages, like prolonged therapeutic effect, reduced side-effects, improved bioavailability, better patient compliance and easy termination of drug therapy. The stratum corneum is considered as the rate limiting barrier in transdermal permeation of most molecules. There are three main routes of drug penetration, which include the appendageal, transcellular and intercellular routes. Skin age, condition, physicochemical factors and environmental factors are some factors that are to be considered while delivering drug through this route. Basic components of TDDS include polymer matrix, membrane, drug, penetration enhancers, pressure-sensitive adhesives, backing laminates, release liner, etc. Transdermal patches can be divided into various systems like reservoir system, matrix system and micro-reservoir system, which are used to incorporate the active ingredients into the circulatory system via the skin. After preparation of transdermal patches, consistent methodology are adopted to test the adhesion properties, physicochemical properties, in vitro drug release studies, in vitro skin permeation studies, skin irritation studies and stability studies. According to the duration of therapy, various drugs are commercially available in the form of transdermal patches.

  6. Environmental Risk

    Data.gov (United States)

    Kansas Data Access and Support Center — The Identified Sites coverage, used to support the environmental quality program, references types and concentrations of contaminants, contaminated media and...

  7. Henig Proper Efficient Points and Generalized Henig Proper Efficient Points

    Institute of Scientific and Technical Information of China (English)

    Jing Hui QIU

    2009-01-01

    Applying the theory of locally convex spaces to vector optimization,we investigate the relationship between Henig proper efficient points and generalized Henig proper efficient points. In particular,we obtain a sufficient and necessary condition for generalized Henig proper efficient points to be Henig proper efficient points. From this,we derive several convenient criteria for judging Henig proper efficient points.

  8. "Bronchial Artery Delivery of Viral Vectors for Gene delivery in Cystic Fibrosis; Superior to Airway Delivery?"

    Directory of Open Access Journals (Sweden)

    Coutelle Charles C

    2002-04-01

    Full Text Available Abstract Background Attempts at gene therapy for the pulmonary manifestations of Cystic Fibrosis have relied mainly on airway delivery. However the efficiency of gene transfer and expression in the airway epithelia has not reached therapeutic levels. Access to epithelial cells is not homogenous for a number of reasons and the submucosal glands cannot be reached via the airways. Presentation We propose to inject gene delivery vectors directly into bronchial arteries combined with pre-delivery of vascular endothelial growth factor to increase vascular endothelial permeability and post-delivery flow reduction by balloon occlusion. Thus it may be possible to reach mucous secreting cells of the bronchial luminal epithelium and the submucosal glands in an increased and homogenous fashion. Testing This combination of techniques to the best of our knowledge has not previously been investigated, and may enable us to overcome some of the current limitations to gene therapy for Cystic Fibrosis.

  9. Neonatal outcomes and operative vaginal delivery versus cesarean delivery.

    LENUS (Irish Health Repository)

    Contag, Stephen A

    2010-06-01

    We compared outcomes for neonates with forceps-assisted, vacuum-assisted, or cesarean delivery in the second stage of labor. This is a secondary analysis of a randomized trial in laboring, low-risk, nulliparous women at >or=36 weeks\\' gestation. Neonatal outcomes after use of forceps, vacuum, and cesarean were compared among women in the second stage of labor at station +1 or below (thirds scale) for failure of descent or nonreassuring fetal status. Nine hundred ninety women were included in this analysis: 549 (55%) with an indication for delivery of failure of descent and 441 (45%) for a nonreassuring fetal status. Umbilical cord gases were available for 87% of neonates. We found no differences in the base excess (P = 0.35 and 0.78 for failure of descent and nonreassuring fetal status) or frequencies of pH below 7.0 (P = 0.73 and 0.34 for failure of descent and nonreassuring fetal status) among the three delivery methods. Birth outcomes and umbilical cord blood gas values were similar for those neonates with a forceps-assisted, vacuum-assisted, or cesarean delivery in the second stage of labor. The occurrence of significant fetal acidemia was not different among the three delivery methods regardless of the indication.

  10. The quantum change point

    CERN Document Server

    Sentís, Gael; Calsamiglia, John; Chiribella, Giulio; Munoz-Tapia, Ramon

    2016-01-01

    Sudden changes are ubiquitous in nature. Identifying them is of crucial importance for a number of applications in medicine, biology, geophysics, and social sciences. Here we investigate the problem in the quantum domain, considering a source that emits particles in a default state, until a point where it switches to another state. Given a sequence of particles emitted by the source, the problem is to find out where the change occurred. For large sequences, we obtain an analytical expression for the maximum probability of correctly identifying the change point when joint measurements on the whole sequence are allowed. We also construct strategies that measure the particles individually and provide an online answer as soon as a new particle is emitted by the source. We show that these strategies substantially underperform the optimal strategy, indicating that quantum sudden changes, although happening locally, are better detected globally.

  11. Point clouds in BIM

    Science.gov (United States)

    Antova, Gergana; Kunchev, Ivan; Mickrenska-Cherneva, Christina

    2016-10-01

    The representation of physical buildings in Building Information Models (BIM) has been a subject of research since four decades in the fields of Construction Informatics and GeoInformatics. The early digital representations of buildings mainly appeared as 3D drawings constructed by CAD software, and the 3D representation of the buildings was only geometric, while semantics and topology were out of modelling focus. On the other hand, less detailed building representations, with often focus on ‘outside’ representations were also found in form of 2D /2,5D GeoInformation models. Point clouds from 3D laser scanning data give a full and exact representation of the building geometry. The article presents different aspects and the benefits of using point clouds in BIM in the different stages of a lifecycle of a building.

  12. Quantum Change Point

    Science.gov (United States)

    Sentís, Gael; Bagan, Emilio; Calsamiglia, John; Chiribella, Giulio; Muñoz-Tapia, Ramon

    2016-10-01

    Sudden changes are ubiquitous in nature. Identifying them is crucial for a number of applications in biology, medicine, and social sciences. Here we take the problem of detecting sudden changes to the quantum domain. We consider a source that emits quantum particles in a default state, until a point where a mutation occurs that causes the source to switch to another state. The problem is then to find out where the change occurred. We determine the maximum probability of correctly identifying the change point, allowing for collective measurements on the whole sequence of particles emitted by the source. Then, we devise online strategies where the particles are measured individually and an answer is provided as soon as a new particle is received. We show that these online strategies substantially underperform the optimal quantum measurement, indicating that quantum sudden changes, although happening locally, are better detected globally.

  13. Floating point coprocessor upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Weber, T.

    1987-04-01

    A method was developed to increase the throughput of the Hewlett Packard, 98635A floating point processor equipped, model 236C computer. The increase was carried out in three phases each with a clock and or chip change during the modification. Two programs were written to test the results and evaluate the increases in performance made to the computer. The first one shows reduction in processing times of 34.3%, while the other recorded 34.6%.

  14. Pointing a solar telescope

    Science.gov (United States)

    Wallace, Patrick

    2016-07-01

    As far as pointing is concerned, a solar telescope is merely an ordinary astronomical telescope but with enhancements for observing solar and coronal features. The paper discusses the additional coordinate systems that need to be supported, shows how to generate the required solar ephemerides (both orbital and physical), and sets out a suitable application programming interface for the telescope control system to use when making solar observations.

  15. Environmental Restoration

    Energy Technology Data Exchange (ETDEWEB)

    Zeevaert, T.; Vanmarcke, H

    1998-07-01

    The objectives of SCK-CEN's programme on environmental restoration are (1) to optimize and validate models for the impact assessment from environmental, radioactive contaminations, including waste disposal or discharge; (2) to support the policy of national authorities for public health and radioactive waste management. Progress and achievements in 1997 are reported.

  16. Environmental assessment.

    Science.gov (United States)

    Narayan, M C; Tennant, J

    1997-11-01

    The significance, standard elements, components, and documentation of an environmental assessment in home care are discussed. This assessment is delineated within Maslow's Hierarchy of Needs and from a functional perspective. An Environmental Assessment Form that can be used as a documentation tool is included.

  17. Environmental occurrences

    Energy Technology Data Exchange (ETDEWEB)

    Black, D.G.

    1995-06-01

    This section of the 1994 Hanford Site Environmental Report summarizes the onsite and offsite releases of radioactive and regulated materials. The specific agencies notified of the releases depended on the type, amount, and location of the individual occurrences. The more significant of these off-normal environmental occurrences are summarized in this section.

  18. Fast approximate delivery of fluence maps: the single map case

    CERN Document Server

    Craft, David

    2016-01-01

    In this first paper of a two-paper series, we present a method for optimizing the dynamic delivery of fluence maps in radiation therapy. For a given fluence map and a given delivery time, the optimization of the leaf trajectories of a multi-leaf collimator to approximately form the given fluence map is a non-convex optimization problem. Its general solution has not been addressed in the literature, despite the fact that dynamic delivery of fluence maps has long been a common approach to intensity modulated radiation therapy. We model the leaf trajectory and dose rate optimization as a non-convex continuous optimization problem and solve it by an interior point method from randomly initialized feasible starting solutions. We demonstrate the method on a fluence map from a prostate case and a larger fluence map from a head-and-neck case. While useful for static beam IMRT delivery, our main motivation for this work is the extension to the case of sequential fluence map delivery, i.e. the case of VMAT, which is th...

  19. Soft Interaction in Liposome Nanocarriers for Therapeutic Drug Delivery

    Directory of Open Access Journals (Sweden)

    Domenico Lombardo

    2016-06-01

    Full Text Available The development of smart nanocarriers for the delivery of therapeutic drugs has experienced considerable expansion in recent decades, with the development of new medicines devoted to cancer treatment. In this respect a wide range of strategies can be developed by employing liposome nanocarriers with desired physico-chemical properties that, by exploiting a combination of a number of suitable soft interactions, can facilitate the transit through the biological barriers from the point of administration up to the site of drug action. As a result, the materials engineer has generated through the bottom up approach a variety of supramolecular nanocarriers for the encapsulation and controlled delivery of therapeutics which have revealed beneficial developments for stabilizing drug compounds, overcoming impediments to cellular and tissue uptake, and improving biodistribution of therapeutic compounds to target sites. Herein we present recent advances in liposome drug delivery by analyzing the main structural features of liposome nanocarriers which strongly influence their interaction in solution. More specifically, we will focus on the analysis of the relevant soft interactions involved in drug delivery processes which are responsible of main behaviour of soft nanocarriers in complex physiological fluids. Investigation of the interaction between liposomes at the molecular level can be considered an important platform for the modeling of the molecular recognition processes occurring between cells. Some relevant strategies to overcome the biological barriers during the drug delivery of the nanocarriers are presented which outline the main structure-properties relationships as well as their advantages (and drawbacks in therapeutic and biomedical applications.

  20. The relationship between pregnancy, preterm and premature delivery

    Directory of Open Access Journals (Sweden)

    Soleymani-e- Shayesteh Y

    2002-06-01

    Full Text Available During pregnancy, different froms of periodontal disease such as pregnancy gingivitis, pregnancy tumors, pregnancy stomatitis, may be encountered. But the most considerable point is the pregnant women's infection with periodontal disease and its effect on delivery and weight of newborn infants. Based on the latest researches and statistics, it is concluded that periodontal disease is an important risk factor, leading to preterm or premature delivery. On the other hand, poor hygiene, should be considered as another danger, resulting in premature delivery. Besides, the presence of a collection of oral fosobacteria in ammoniutic fluid in mothers with premature delivery, increases the probability of an oral- haematogenous connection. Moreover, prostaglandin E2, in cervicular fluid, has been considered as an index for periodontal disease activity and loss of weight at the time of birth. These findings suggest that effective steps, to prevent preterm delivery, can be taken, if women, genycologists and dentists have enough knowledge. This article focuses on the special supervision that is required to prevent the effects of hormonal changes on periodontal tissues and conversely to reduce systemic disorders resulting from periodontal disease, in pregnant woman.

  1. Corporate environmentalism and environmental innovation.

    Science.gov (United States)

    Chang, Ching-Hsing; Sam, Abdoul G

    2015-04-15

    Several papers have explored the effect of tighter environmental standards on environmental innovation. While mandatory regulation remains the central tenet of US environmental policy, the regulatory landscape has changed since the early 1990s with the increased recourse by federal and state agencies to corporate environmentalism--voluntary pollution prevention (P2) by firms--to achieve environmental improvements. We therefore estimate the effects of voluntary P2 activities on the patenting of environmental technologies by a sample of manufacturing firms. With our panel data of 352 firms over the 1991-2000 period, we adopt an instrumental variable Poisson framework to account for the count nature of patents and the endogeneity of the P2 adoption decision. Our results indicate that the adoption of voluntary P2 activities in the manufacturing sector has led to a statistically and economically significant increase in the number of environmental patents, suggesting that corporate environmentalism can act as a catalyst for investments in cleaner technologies. Our findings are internationally relevant given the increasing ubiquity of corporate environmentalism in both developed and developing economies. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. TEGA Sample Delivery and Analysis (Animation)

    Science.gov (United States)

    2008-01-01

    [figure removed for brevity, see original site] Click on image for animation This animation shows NASA's Phoenix Lander's Robotic Arm scoop delivering a sample to the Thermal and Evolved-Gas Analyzer (TEGA) and how samples are analyzed within the instrument. TEGA has eight tiny ovens for measuring constituents in the atmosphere and in the soil, including possible organic constituents and the melting point of ice. The scoop drops soil onto a fine mesh screen between TEGA's open doors. Some soil passes through the screen, which vibrates, into the throat of a funnel, where a spinning device called the 'whirligig' aids delivery into one half of a tiny oven. The soil sample is represented here by the white chip. The filled oven half then rotates and mates with the other oven half, closing the complete oven so sample heating can begin. The purple coil in this animation is the spring that moves the oven halves together. Heating occurs at successively higher temperatures over several days. The energy required to heat the sample is measured to discover its thermal properties. Gases driven off during sample heating pass through tubing to the mass spectrometer for analysis. Note that the exterior doors above the screen never close after sample delivery. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASAaE(TM)s Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  3. Animation of TEGA Sample Delivery and Analysis

    Science.gov (United States)

    2008-01-01

    [figure removed for brevity, see original site] Click on image to view the animation This animation shows NASA's Phoenix Lander's Robotic Arm scoop delivering a sample to the Thermal and Evolved-Gas Analyzer (TEGA) and how samples are analyzed within the instrument. TEGA has eight tiny ovens for measuring constituents in the atmosphere and in the soil, including possible organic constituents and the melting point of ice. The scoop drops soil onto a fine mesh screen between TEGA's open doors. Some soil passes through the screen, which vibrates, into the throat of a funnel, where a spinning device called the 'whirligig' aids delivery into one half of a tiny oven. The soil sample is represented here by the white chip. The filled oven half then rotates and mates with the other oven half, closing the complete oven so sample heating can begin. The purple coil in this animation is the spring that moves the oven halves together. Heating occurs at successively higher temperatures over several days. The energy required to heat the sample is measured to discover its thermal properties. Gases driven off during sample heating pass through tubing to the mass spectrometer for analysis. Note that the exterior doors above the screen never close after sample delivery. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  4. Diamond encapsulated photovoltaics for transdermal power delivery.

    Science.gov (United States)

    Ahnood, A; Fox, K E; Apollo, N V; Lohrmann, A; Garrett, D J; Nayagam, D A X; Karle, T; Stacey, A; Abberton, K M; Morrison, W A; Blakers, A; Prawer, S

    2016-03-15

    A safe, compact and robust means of wireless energy transfer across the skin barrier is a key requirement for implantable electronic devices. One possible approach is photovoltaic (PV) energy delivery using optical illumination at near infrared (NIR) wavelengths, to which the skin is highly transparent. In the work presented here, a subcutaneously implantable silicon PV cell, operated in conjunction with an external NIR laser diode, is developed as a power delivery system. The biocompatibility and long-term biostability of the implantable PV is ensured through the use of an hermetic container, comprising a transparent diamond capsule and platinum wire feedthroughs. A wavelength of 980 nm is identified as the optimum operating point based on the PV cell's external quantum efficiency, the skin's transmission spectrum, and the wavelength dependent safe exposure limit of the skin. In bench-top experiments using an external illumination intensity of 0.7 W/cm(2), a peak output power of 2.7 mW is delivered to the implant with an active PV cell dimension of 1.5 × 1.5 × 0.06 mm(3). This corresponds to a volumetric power output density of ~20 mW/mm(3), significantly higher than power densities achievable using inductively coupled coil-based approaches used in other medical implant systems. This approach paves the way for further ministration of bionic implants.

  5. Environmental taxes

    DEFF Research Database (Denmark)

    Ekins, P.; Andersen, Mikael Skou; Vos, H.

    on their environmental effectiveness and on the political barriers to their implementation. It provides illustrative examples of environmental taxes only; comprehensive reviews are available from OECD (1995).http://www.eea.europa.eu/publications/92-9167-000-6-sum/page002.html [Summary available in 10 languages]...... been identified and reviewed in this report. Within the limitations of the studies, it appears that these taxes have been environmentally effective (achieving their environmental objectives) and they seem to have achieved such objectives at reasonable cost. Examples of particularly successful taxes...... to implementation, especially of energy (particularly on specific sectors or regions); and on low income groups can be overcome by: a) careful design, b) the use of environmental taxes and respective revenues as part of policy packages and green tax reforms, c) gradual implementation; d) extensive consultation...

  6. Building Points - MO 2012 Stoddard Structure Points (SHP)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Missouri Structure Points are structure points generated from a two pass look over the 2007 State 2ft imagery. Unlike the structure footprints, the building point...

  7. Building Points - MO 2012 Dunklin Structure Points (SHP)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Missouri Structure Points are structure points generated from a two pass look over the 2007 State 2ft imagery. Unlike the structure footprints, the building point...

  8. Building Points - MO 2012 Scott Structure Points (SHP)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Missouri Structure Points are structure points generated from a two pass look over the 2007 State 2ft imagery. Unlike the structure footprints, the building point...

  9. Building Points - MO 2012 Pemiscot Structure Points (SHP)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Missouri Structure Points are structure points generated from a two pass look over the 2007 State 2ft imagery. Unlike the structure footprints, the building point...

  10. Building Points - MO 2012 New Madrid Structure Points (SHP)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Missouri Structure Points are structure points generated from a two pass look over the 2007 State 2ft imagery. Unlike the structure footprints, the building point...

  11. Building Points - MO 2012 Mississippi Structure Points (SHP)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Missouri Structure Points are structure points generated from a two pass look over the 2007 State 2ft imagery. Unlike the structure footprints, the building point...

  12. Delivery Time Reliability Model of Logistics Network

    OpenAIRE

    Liusan Wu; Qingmei Tan; Yuehui Zhang

    2013-01-01

    Natural disasters like earthquake and flood will surely destroy the existing traffic network, usually accompanied by delivery delay or even network collapse. A logistics-network-related delivery time reliability model defined by a shortest-time entropy is proposed as a means to estimate the actual delivery time reliability. The less the entropy is, the stronger the delivery time reliability remains, and vice versa. The shortest delivery time is computed separately based on two different assum...

  13. Advanced content delivery, streaming, and cloud services

    CERN Document Server

    Sitaraman, Ramesh Kumar; Robinson, Dom

    2014-01-01

    While other books on the market provide limited coverage of advanced CDNs and streaming technologies, concentrating solely on the fundamentals, this book provides an up-to-date comprehensive coverage of the state-of-the-art advancements in CDNs, with a special focus on Cloud-based CDNs. The book includes CDN and media streaming basics, performance models, practical applications, and business analysis. It features industry case studies, CDN applications, and open research issues to aid practitioners and researchers, and a market analysis to provide a reference point for commercial entities. The book covers Adaptive Bitrate Streaming (ABR), Content Delivery Cloud (CDC), Web Acceleration, Front End Optimization (FEO), Transparent Caching, Next Generation CDNs, CDN Business Intelligence and more.

  14. Abandoned Uranium Mine (AUM) Trust Mine Points, Navajo Nation, 2016, US EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — This GIS dataset contains point features that represent mines included in the Navajo Environmental Response Trust. This mine category also includes Priority mines....

  15. A Review of Multi-Responsive Membranous Systems for Rate-Modulated Drug Delivery

    OpenAIRE

    Shaikh, Rubina P.; Pillay, Viness; Choonara, Yahya E.; du Toit, Lisa C.; Ndesendo, Valence M.K.; Bawa, Priya; Cooppan, Shivaan

    2010-01-01

    Membrane technology is broadly applied in the medical field. The ability of membranous systems to effectively control the movement of chemical entities is pivotal to their significant potential for use in both drug delivery and surgical/medical applications. An alteration in the physical properties of a polymer in response to a change in environmental conditions is a behavior that can be utilized to prepare ‘smart’ drug delivery systems. Stimuli-responsive or ‘smart’ polymers are polymers tha...

  16. STUDY OF THE CRUDE BIRTH RATE AND DELIVERY CONDITION AMONG THE QASHQAI TRIBE, SOUTHERN IRAN

    Directory of Open Access Journals (Sweden)

    M. Motabar

    1976-11-01

    Full Text Available On the basis of a cross-sectional demographic survey that was conducted among the Qashqai Tribe of southern Iran in 1973, the crude birth rate was estimated at 48.2 per thousand per year. The most productive age groups, was 25-29 years. Forty-nine, point seven per cent (49.7% or about one half of the total births occurred among married women aged 20 to 29 years Eighty-seven point three per cent (87.3% of the deliveries took place in tents, only one per cent at maternity hospitals. Ninety point one per cent (90.1% of babies were delivered with the help of relative and friends, while only 6.9 per cent of all deliveries took place with the aid of midwives. Eighty-nine point seven per cent (89.7% of deliveries were performed without medical expenses.

  17. Tipping point leadership.

    Science.gov (United States)

    Kim, W Chan; Mauborgne, Renée

    2003-04-01

    When William Bratton was appointed police commissioner of New York City in 1994, turf wars over jurisdiction and funding were rife and crime was out of control. Yet in less than two years, and without an increase in his budget, Bratton turned New York into the safest large city in the nation. And the NYPD was only the latest of five law-enforcement agencies Bratton had turned around. In each case, he succeeded in record time despite limited resources, a demotivated staff, opposition from powerful vested interests, and an organization wedded to the status quo. Bratton's turnarounds demonstrate what the authors call tipping point leadership. The theory of tipping points hinges on the insight that in any organization, fundamental changes can occur quickly when the beliefs and energies of a critical mass of people create an epidemic movement toward an idea. Bratton begins by overcoming the cognitive hurdles that block organizations from recognizing the need for change. He does this by putting managers face-to-face with operational problems. Next, he manages around limitations on funds, staff, or equipment by concentrating resources on the areas that are most in need of change and that have the biggest payoffs. He meanwhile solves the motivation problem by singling out key influencers--people with disproportionate power due to their connections or persuasive abilities. Finally, he closes off resistance from powerful opponents. Not every CEO has the personality to be a Bill Bratton, but his successes are due to much more than his personality. He relies on a remarkably consistent method that any manager looking to turn around an organization can use to overcome the forces of inertia and reach the tipping point.

  18. Pointing the SOFIA Telescope

    CERN Document Server

    Gross, Michael A K; Moore, Elizabeth M

    2010-01-01

    SOFIA is an airborne, gyroscopically stabilized 2.5m infrared telescope, mounted to a spherical bearing. Unlike its predecessors, SOFIA will work in absolute coordinates, despite its continually changing position and attitude. In order to manage this, SOFIA must relate equatorial and telescope coordinates using a combination of avionics data and star identification, manage field rotation and track sky images. We describe the algorithms and systems required to acquire and maintain the equatorial reference frame, relate it to tracking imagers and the science instrument, set up the oscillating secondary mirror, and aggregate pointings into relocatable nods and dithers.

  19. Ubiquitous Pointing and Drawing

    Directory of Open Access Journals (Sweden)

    Kristian Jantz

    2007-12-01

    Full Text Available This paper presents a system that enables a presenter to work directly on the projection without the typical interruption of the presentation flow being caused by a mouse or keyboard activity. The lecturer simply uses his fingers as a natural and intuitive pointing device. The system consists of an LED, a standard webcam, a video projector, and a small software system running on a notebook computer. The camera is positioned such that it views the projection area. After a few calibration clicks, the mouse emulation is functional at any place of the projection area.

  20. Critical Points of Contact

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Morelli, Nicola

    2011-01-01

    where the networks meet and establish contact. Thus we argue for the usefulness of the notion of Critical Point of Contact (CPC) to deepen our understanding of the actual life within networks. En route to this notion we draw upon theories within as diverse realms such as interaction design, service...... design, geography, and mobility studies. After the introduction in section we develop and define the notion of CPC based upon a broad set of disciplines and theories. We illustrate the usefulness of the notion within the field of mobility in the network city and within the field of service design...

  1. Interior-point methods

    Science.gov (United States)

    Potra, Florian A.; Wright, Stephen J.

    2000-12-01

    The modern era of interior-point methods dates to 1984, when Karmarkar proposed his algorithm for linear programming. In the years since then, algorithms and software for linear programming have become quite sophisticated, while extensions to more general classes of problems, such as convex quadratic programming, semi-definite programming, and nonconvex and nonlinear problems, have reached varying levels of maturity. We review some of the key developments in the area, including comments on both the complexity theory and practical algorithms for linear programming, semi-definite programming, monotone linear complementarity, and convex programming over sets that can be characterized by self-concordant barrier functions.

  2. Environmental Management

    DEFF Research Database (Denmark)

    Lehmann, Martin

    The doctoral research project is co-financed by DUCED-I&UA and is part of a joint effort of Thai, Malay, South African and Danish universities to conduct collaborative research on the overarching theme "Environmental Management: Globalisation and Industrial Governance in Developing Countries......". The PhD project is expected to conclude ultimo 2005. Environmental management and cleaner production (CP) are both internationally recognised as tools for minimising environmental impacts of production or services. However, several studies have shown that especially SMEs, which probably amount to more...

  3. Environmental Management

    DEFF Research Database (Denmark)

    Lehmann, Martin

    The doctoral research project is co-financed by DUCED-I&UA and is part of a joint effort of Thai, Malay, South African and Danish universities to conduct collaborative research on the overarching theme "Environmental Management: Globalisation and Industrial Governance in Developing Countries......". The PhD project is expected to conclude ultimo 2005. Environmental management and cleaner production (CP) are both internationally recognised as tools for minimising environmental impacts of production or services. However, several studies have shown that especially SMEs, which probably amount to more...

  4. Cesarean delivery on maternal request and childhood intelligence: a cohort study

    Institute of Scientific and Technical Information of China (English)

    LI Hong-tian; YE Rong-wei; PEI Li-jun; REN Ai-guo; ZHENG Xiao-ying; LIU Jian-meng

    2011-01-01

    Background Cesarean section births have been steadily increasing over the past decade and have become an epidemic in China.Cesarean delivery on maternal request is a major contributor to this upward trend,and there has been of much concern about its impact on maternal and child health.Most of mothers believe that cesarean delivery on maternal request can improve the child's intelligence,but direct evidence is sparse.In this cohort study,we aimed to directly assess the impact of cesarean delivery on maternal request on childhood intelligence.Methods Intelligence quotient (IQ) of 4144 preschool children from 21 cities/counties of Zhejiang and Jiangsu province whose mothers were registered in a population-based perinatal surveillance program during 1993-1996 was assessed with Chinese Wechsler Young Children Scale of Intelligence (C-WYCSI) in 2000.The outcomes were full-scale IQ,verbal IQ,and performance IQ of C-WYCSI.Mode of delivery and covariates were obtained from the surveillance program.We estimated unadjusted and adjusted effects of cesarean delivery on maternal request and assisted vaginal delivery on IQ scores compared with spontaneous vaginal delivery using regression analysis.Results The mean full-scale,verbal,and performance IQ for all children was 99.3±16.1,93.6±17.7,and 105.3±14.3.In crude analysis,cesarean delivery on maternal request versus spontaneous vaginal delivery was associated with an increase of 3.9 (95% confidence interval,0.6 to 7.2) points in full-scale IQ,4.8 (1.2 to 8.4) points in verbal IQ,and 2.4(-0.6 to 5.3) points in performance IQ.After adjusting for maternal education,occupation,and IQ,the advantage was reduced to 1.6 (-1.3 to 4.5),2.3 (-0.8 to 5.5),and 0.6 (-2.0 to 3.3) points for full-scale,verbal,and performance IQ,respectively.Assisted vaginal delivery versus spontaneous vaginal delivery was not associated with IQ scores in any analysis.Conclusion Neither cesarean delivery on maternal request nor assisted vaginal delivery

  5. "Wagging the dog": How service delivery can lose its way in the procurement maze -- and could find it again

    CSIR Research Space (South Africa)

    Wall, K

    2012-09-01

    Full Text Available delivery can lose its way in the procurement maze -- and could find it again Kevin Wall, Ron Watermeyer and Graham Pirie Kevin Wall (CSIR); Ron Watermeyer (Soderlund and Schutte); Graham Pirie (Consulting Engineers South Africa (CESA... with the provisions of the Preferential Policy Framework Act, 2000 and points for quality scored out of maximum of 100 points. The points for the preference points system are added to the points for quality in terms of the weightings stipulated in the procurement...

  6. Nanosuspension Technology for Drug Delivery

    Directory of Open Access Journals (Sweden)

    Jiraporn CHINGUNPITUK

    2007-06-01

    Full Text Available The poor water solubility of drugs is major problem for drug formulation. To date, nanoscale systems for drug delivery have gained much interest as a way to improve the solubility problems. The reduction of drug particles into the sub-micron range leads to a significant increase in the dissolution rate and therefore enhances bioavailability. Nanosuspensions are promising candidates that can be used for enhancing the dissolution of poorly water soluble drugs. Nanosuspensions contain submicron colloidal dispersion of pharmaceutical active ingredient particles in a liquid phase stabilized by surfactants. Production of drugs as nanosuspensions has been developed for drug delivery systems as an oral formulation and non-oral administration. This review describes the methods of pharmaceutical nanosuspension production, formulations and pharmaceutical applications in drug delivery as well as the marketed products.

  7. Albumin-based drug delivery

    DEFF Research Database (Denmark)

    Larsen, Maja Thim; Kuhlmann, Matthias; Hvam, Michael Lykke

    2016-01-01

    The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand...... binding sites, cellular receptor engagement, and a long circulatory half-life due to interaction with the recycling neonatal Fc receptor. Exploitation of these properties promotes albumin as an attractive candidate for half-life extension and targeted intracellular delivery of drugs attached by covalent...... conjugation, genetic fusions, association or ligand-mediated association. This review will give an overview of albumin-based products with focus on the natural biological properties and molecular interactions that can be harnessed for the design of a next-generation drug delivery platform....

  8. SPIRE Point Source Photometry

    CERN Document Server

    Pearson, Chris; North, Chris; Bendo, George; Conversi, Luca; Dowell, Darren; Griffin, Matt; Jin, Terry; Laporte, Nicolas; Papageorgiou, Andreas; Schulz, Bernhard; Shupe, Dave; Smith, Anthony J; Xu, Kevin

    2014-01-01

    The different algorithms appropriate for point source photometry on data from the SPIRE instrument on-board the Herschel Space Observatory, within the Herschel Interactive Processing Environment (HIPE) are compared. Point source photometry of a large ensemble of standard calibration stars and dark sky observations is carried out using the 4 major methods within HIPE: SUSSEXtractor, DAOphot, the SPIRE Timeline Fitter and simple Aperture Photometry. Colour corrections and effective beam areas as a function of the assumed source spectral index are also included to produce a large number of photometric measurements per individual target, in each of the 3 SPIRE bands (250, 350, 500um), to examine both the accuracy and repeatability of each of the 4 algorithms. It is concluded that for flux densities down to the level of 30mJy that the SPIRE Timeline Fitter is the method of choice. However, at least in the 250 and 350um bands, all 4 methods provide photometric repeatability better than a few percent down to at appr...

  9. Relative Critical Points

    Directory of Open Access Journals (Sweden)

    Debra Lewis

    2013-05-01

    Full Text Available Relative equilibria of Lagrangian and Hamiltonian systems with symmetry are critical points of appropriate scalar functions parametrized by the Lie algebra (or its dual of the symmetry group. Setting aside the structures – symplectic, Poisson, or variational – generating dynamical systems from such functions highlights the common features of their construction and analysis, and supports the construction of analogous functions in non-Hamiltonian settings. If the symmetry group is nonabelian, the functions are invariant only with respect to the isotropy subgroup of the given parameter value. Replacing the parametrized family of functions with a single function on the product manifold and extending the action using the (coadjoint action on the algebra or its dual yields a fully invariant function. An invariant map can be used to reverse the usual perspective: rather than selecting a parametrized family of functions and finding their critical points, conditions under which functions will be critical on specific orbits, typically distinguished by isotropy class, can be derived. This strategy is illustrated using several well-known mechanical systems – the Lagrange top, the double spherical pendulum, the free rigid body, and the Riemann ellipsoids – and generalizations of these systems.

  10. Relative Critical Points

    Science.gov (United States)

    Lewis, Debra

    2013-05-01

    Relative equilibria of Lagrangian and Hamiltonian systems with symmetry are critical points of appropriate scalar functions parametrized by the Lie algebra (or its dual) of the symmetry group. Setting aside the structures - symplectic, Poisson, or variational - generating dynamical systems from such functions highlights the common features of their construction and analysis, and supports the construction of analogous functions in non-Hamiltonian settings. If the symmetry group is nonabelian, the functions are invariant only with respect to the isotropy subgroup of the given parameter value. Replacing the parametrized family of functions with a single function on the product manifold and extending the action using the (co)adjoint action on the algebra or its dual yields a fully invariant function. An invariant map can be used to reverse the usual perspective: rather than selecting a parametrized family of functions and finding their critical points, conditions under which functions will be critical on specific orbits, typically distinguished by isotropy class, can be derived. This strategy is illustrated using several well-known mechanical systems - the Lagrange top, the double spherical pendulum, the free rigid body, and the Riemann ellipsoids - and generalizations of these systems.

  11. Reassessing Function Points

    Directory of Open Access Journals (Sweden)

    G.R. Finnie

    1997-05-01

    Full Text Available Accurate estimation of the size and development effort for software projects requires estimation models which can be used early enough in the development life cycle to be of practical value. Function Point Analysis (FPA has become possibly the most widely used estimation technique in practice. However the technique was developed in the data processing environment of the 1970's and, despite undergoing considerable reassessment and formalisation, still attracts criticism for the weighting scoring it employs and for the way in which the function point score is adapted for specific system characteristics. This paper reviews the validity of the weighting scheme and the value of adjusting for system characteristics by studying their effect in a sample of 299 software developments. In general the value adjustment scheme does not appear to cater for differences in productivity. The weighting scheme used to adjust system components in terms of being simple, average or complex also appears suspect and should be redesigned to provide a more realistic estimate of system functionality.

  12. National Pollution Discharge Elimination System (NPDES) Facility Points, Region 9, 2007, US EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — Point geospatial dataset representing locations of NPDES Facilities. NPDES (National Pollution Discharge Elimination System) is an EPA permit program that regulates...

  13. Environmental sciences

    NARCIS (Netherlands)

    Kwa, C.; Wright, J.D.

    2015-01-01

    The environmental sciences are engaged in a remarkable effort of interdisciplinary cooperation and integration. Some long-running international scientific programs, notably the World Climate Research Programme and the International Geosphere-Biosphere Programme, play an important role therein. The

  14. Environmental decontamination

    Energy Technology Data Exchange (ETDEWEB)

    Cristy, G.A.; Jernigan, H.C. (eds.)

    1981-02-01

    The record of the proceedings of the workshop on environmental decontamination contains twenty-seven presentations. Emphasis is placed upon soil and surface decontamination, the decommissioning of nuclear facilities, and assessments of instrumentation and equipment used in decontamination. (DLS)

  15. Environmental Health

    Science.gov (United States)

    Our environment affects our health. If parts of the environment, like the air, water, or soil become polluted, it ... in the home can trigger asthma attacks. Some environmental risks are a part of the natural world, ...

  16. Abandoned Uranium Mine (AUM) Points, Navajo Nation, 2016, US EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — This GIS dataset contains point features of all Abandoned Uranium Mines (AUMs) on or within one mile of the Navajo Nation. Points are centroids developed from the...

  17. Conference on Environmental Data Management

    CERN Document Server

    Oppenheimer, Dorothy; Brogden, William; Environmental Data Management

    1976-01-01

    Throughout the world a staggering amount of resources have been used to obtain billions of environmental data points. Some, such as meteorological data, have been organized for weather map display where many thousands of data points are synthesized in one compressed map. Most environmental data, however, are still widely scattered and generally not used for a systems approach, but only for the purpose for which they were originally taken. These data are contained in relatively small computer programs, research files, government and industrial reports, etc. This Conference was called to bring together some of the world's leaders from research centers and government agencies, and others concerned with environmental data management. The purpose of the Conference was to organize discussion on the scope of world environmental data, its present form and documentation, and whether a systematic approach to a total system is feasible now or in the future. This same subject permeated indirectly the Stockholm Conference...

  18. Environmental teratogens.

    OpenAIRE

    Brent, R. L.; Beckman, D. A.

    1990-01-01

    By far the largest category of malformations, 65% falls into the group of those with an unknown cause(s). Purely genetic causes of malformations (autosomal and cytogenetic), estimated to produce 20 to 25% of all human malformations, comprise the largest group of congenital malformations with known etiology. Although environmental causes of human malformations account for 10% or fewer of malformations, most of these environmentally induced malformations are related to maternal disease states. ...

  19. 农业面源污染治理的政策效用评估以江苏省海安县的测土配方施肥推广为例%Agricultural Non-point Source Pollution Controlling Policy's Utility Evaluation Based on Environmental Cost:A Case Study of Soil Testing and Fertilizer Recommendation Technology in Hai'an County

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    为衡量农业面源污染治理政策的作用效果,文章基于环境成本的视角,探索了农业面源污染治理政策效用评估的一般方法与步骤。首先,结合农业化肥的环境污染特点,利用输出系数模型以实现对区域内农业化肥造成的总氮TN、总磷TP排放量的合理测算。然后,建立了基于能值分析法的环境成本估计模型,并结合经济成本和经济收益,构建了基于成本-收益分析的农业面源污染治理政策效用评估的一般模型。最后,以江苏省海安县的测土配方施肥技术的推广为例,对海安县测土配方施肥节本增收效果进行综合评价,并探索了江苏省实现测土配方施肥全覆盖时的总体效果,为面源污染治理政策的评估提供思路。%In order to assess the policy effect of controlling agricultural non-point source pollution ,this paper ,based on the perspec‐tive of environmental cost ,explores the general methods and steps for utility evaluation of agricultural non-point source pollution's treatment measures .First of all ,combined with the characteristics of environmental pollution caused by agricultural fertilizer ,this paper chooses a rational export coefficient model to calculate total nitrogen (TN) ,total phosphorus (TP) emissions caused by agri‐cultural fertilizer in the region .Then ,targeted at soil testing and fertilizer recommendation technology ,this paper constructs envi‐ronmental cost estimation model based on energy analysis and general utility evaluation model based on cost-benefit analysis .Finally , this paper takes Hai'an County's promotion of soil testing and fertilizer recommendation in Jiangsu Province for example ,the synthe‐sized evaluation of the technology is achieved in saving costs and increasing income .Further ,this paper explores the beneficial se‐quence when the technology is spread to the whole Jiangsu Province ,which will provide ways to better choose

  20. Point Source Extraction with MOPEX

    CERN Document Server

    Marleau, D M F R

    2005-01-01

    MOPEX (MOsaicking and Point source EXtraction) is a package developed at the Spitzer Science Center for astronomical image processing. We report on the point source extraction capabilities of MOPEX. Point source extraction is implemented as a two step process: point source detection and profile fitting. Non-linear matched filtering of input images can be performed optionally to increase the signal-to-noise ratio and improve detection of faint point sources. Point Response Function (PRF) fitting of point sources produces the final point source list which includes the fluxes and improved positions of the point sources, along with other parameters characterizing the fit. Passive and active deblending allows for successful fitting of confused point sources. Aperture photometry can also be computed for every extracted point source for an unlimited number of aperture sizes. PRF is estimated directly from the input images. Implementation of efficient methods of background and noise estimation, and modified Simplex a...

  1. September 2002 Lidar Point Data of Southern California Coastline: Dana Point to Point La Jolla

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains lidar point data from a strip of Southern California coastline (including water, beach, cliffs, and top of cliffs) from Dana Point to Point La...

  2. May 2002 Lidar Point Data of Southern California Coastline: Dana Point to Point La Jolla

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains lidar point data from a strip of Southern California coastline (including water, beach, cliffs, and top of cliffs) from Dana Point to Point La...

  3. September 2002 Lidar Point Data of Southern California Coastline: Dana Point to Point La Jolla

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains lidar point data from a strip of Southern California coastline (including water, beach, cliffs, and top of cliffs) from Dana Point to Point...

  4. Finding critical points whose polarization is also a critical point

    OpenAIRE

    Squassina, Marco; Van Schaftingen, Jean

    2011-01-01

    We show that near any given minimizing sequence of paths for the mountain pass lemma, there exists a critical point whose polarization is also a critical point. This is motivated by the fact that if any polarization of a critical point is also a critical point and the Euler-Lagrange equation is a second-order semi-linear elliptic problem, T. Bartsch, T. Weth and M. Willem (J. Anal. Math., 2005) have proved that the critical point is axially symmetric.

  5. Environmental Report 1996, Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Harrach, R.J.

    1996-01-01

    This is Volume 2 of the Lawrence Livermore National Laboratory`s (LLNL`s) annual Environmental Report 1996, prepared for the US Department of Energy. Volume 2 supports Volume 1 summary data and is essentially a detailed data report that provides individual data points, where applicable. Volume 2 includes information on monitoring of air, air effluents, sewerable water, surface water, ground water, soil and sediment, vegetation and foodstuff, environmental radiation, and quality assurance.

  6. The Point Mass Concept

    Directory of Open Access Journals (Sweden)

    Lehnert B.

    2011-04-01

    Full Text Available A point-mass concept has been elaborated from the equations of the gravitational field. One application of these deductions results in a black hole configuration of the Schwarzschild type, having no electric charge and no angular momentum. The critical mass of a gravitational collapse with respect to the nuclear binding energy is found to be in the range of 0.4 to 90 solar masses. A second application is connected with the spec- ulation about an extended symmetric law of gravitation, based on the options of positive and negative mass for a particle at given positive energy. This would make masses of equal polarity attract each other, while masses of opposite polarity repel each other. Matter and antimatter are further proposed to be associated with the states of positive and negative mass. Under fully symmetric conditions this could provide a mechanism for the separation of antimatter from matter at an early stage of the universe.

  7. Virtual turning points

    CERN Document Server

    Honda, Naofumi; Takei, Yoshitsugu

    2015-01-01

    The discovery of a virtual turning point truly is a breakthrough in WKB analysis of higher order differential equations. This monograph expounds the core part of its theory together with its application to the analysis of higher order Painlevé equations of the Noumi–Yamada type and to the analysis of non-adiabatic transition probability problems in three levels. As M.V. Fedoryuk once lamented, global asymptotic analysis of higher order differential equations had been thought to be impossible to construct. In 1982, however, H.L. Berk, W.M. Nevins, and K.V. Roberts published a remarkable paper in the Journal of Mathematical Physics indicating that the traditional Stokes geometry cannot globally describe the Stokes phenomena of solutions of higher order equations; a new Stokes curve is necessary.

  8. The Temporal Tipping Point

    DEFF Research Database (Denmark)

    Hermann, A. K.

    2016-01-01

    “Slow journalism” is a term anthropologist and sociologists sometimes use to describe their empirical work, ethnography. To journalists and media observers, meanwhile, “slow journalism” signifies a newfound dedication to serious long-form journalism. Not surprisingly, thus, “ethnographic journalism......”—a genre where reporters adopt research strategies from social science—takes “slow” to the extreme. Immersing themselves in communities for weeks, months and years, ethnographic journalists seek to gain what anthropologists call “the native's point of view”. Based on in-depth interviews with practitioners...... and analyses of their journalistic works, this paper offers a study of ethnographic journalism suggesting that slow time operates in at least three separate registers. First, in terms of regimentation, ethnographic journalism is mostly long-form pieces that demand time-consuming research and careful writing...

  9. Repelling Point Bosons

    Science.gov (United States)

    McGuire, J. B.

    2011-12-01

    There is a body of conventional wisdom that holds that a solvable quantum problem, by virtue of its solvability, is pathological and thus irrelevant. It has been difficult to refute this view owing to the paucity of theoretical constructs and experimental results. Recent experiments involving equivalent ions trapped in a spatial conformation of extreme anisotropic confinement (longitudinal extension tens, hundreds or even thousands of times transverse extension) have modified the view of relevancy, and it is now possible to consider systems previously thought pathological, in particular point Bosons that repel in one dimension. It has been difficult for the experimentalists to utilize existing theory, mainly due to long-standing theoretical misunderstanding of the relevance of the permutation group, in particular the non-commutativity of translations (periodicity) and transpositions (permutation). This misunderstanding is most easily rectified in the case of repelling Bosons.

  10. Latent myofascial trigger points.

    Science.gov (United States)

    Ge, Hong-You; Arendt-Nielsen, Lars

    2011-10-01

    A latent myofascial trigger point (MTP) is defined as a focus of hyperirritability in a muscle taut band that is clinically associated with local twitch response and tenderness and/or referred pain upon manual examination. Current evidence suggests that the temporal profile of the spontaneous electrical activity at an MTP is similar to focal muscle fiber contraction and/or muscle cramp potentials, which contribute significantly to the induction of local tenderness and pain and motor dysfunctions. This review highlights the potential mechanisms underlying the sensory-motor dysfunctions associated with latent MTPs and discusses the contribution of central sensitization associated with latent MTPs and the MTP network to the spatial propagation of pain and motor dysfunctions. Treating latent MTPs in patients with musculoskeletal pain may not only decrease pain sensitivity and improve motor functions, but also prevent latent MTPs from transforming into active MTPs, and hence, prevent the development of myofascial pain syndrome.

  11. Characterisation of zinc delivery from a nipple shield delivery system using a breastfeeding simulation apparatus

    National Research Council Canada - National Science Library

    Scheuerle, Rebekah L; Bruggraber, Sylvaine F. A; Gerrard, Stephen E; Kendall, Richard A; Tuleu, Catherine; Slater, Nigel K. H

    2017-01-01

      Zinc delivery from a nipple shield delivery system (NSDS), a novel platform for administering medicines to infants during breastfeeding, was characterised using a breastfeeding simulation apparatus...

  12. 浊点萃取-电感耦合等离子体质谱法测定环境样品中的痕量铂钯%Determination of trace platinum and palladium in environmental samples by cloud point extraction coupled with inductively coupled plasma-mass spectrometry

    Institute of Scientific and Technical Information of China (English)

    张欣; 刘崴; 李冰; 胡俊栋

    2012-01-01

    Accurate determination of precious metals at trace levels in environmental matrices is still a difficult task because of their complex components and the possible interferences during analyzing. Cloud point extraction (CPE) is a new kind of preconcentration and separation technology which has many prominent virtues such as completely phase separation, easy to be operated, high enrichment efficiency and less harmful for environment and operators. It has been successfully used in the determination of lead, zinc, cobalt, copper and many other metals. But the study about precious metals in environmental matrices using CPE was comparatively few. So in this paper a new method for the determination of trace amounts of platinum and palladium in environmental samples using CPE coupled with ICP-MS is described. Trace amounts of Pt and Pd were extracted from the sample solutions in the form of coordination complex with 2-mercaptobenzothiazole (2-MBT) in 1 mol/L HC1 medium,using a non-ionic surfactant Triton Χ-100. The main parameters affecting extraction and determination were evaluated in detail, such as the solution acidity, the amount of 2-MBT, the concentration of Triton X-100 and SnCl2, the extraction temperature and time, as well as the interferences. Under optimized conditions, the recoveries of Pt and Pd were all above 95%. The detection limits obtained for Pt and Pd were 0. 22 ng/g and 0. 17 ng/g, respectively. CPE has an effective alleviation of interfering ions and a relatively sensitivity for separating the elements of Pt and Pd from large amount of co-existing ions which could influence the subsequent determination by ICP-MS. The method was successfully applied to the analysis of trace amounts of Pt and Pd in water, road dust and soil samples. The results showed that this method is reliable and can meet the most request of Pt and Pd determination in many environmental samples.%建立了浊点萃取-电感耦合等离子体质谱法测定环境样品

  13. Preparing and evaluating delivery systems for proteins

    DEFF Research Database (Denmark)

    Jorgensen, L; Moeller, E H; van de Weert, M

    2006-01-01

    From a formulation perspective proteins are complex and therefore challenging molecules to develop drug delivery systems for. The success of a formulation depends on the ability of the protein to maintain the native structure and activity during preparation and delivery as well as during shipping...... and long-term storage of the formulation. Therefore, the development and evaluation of successful and promising drug delivery systems is essential. In the present review, some of the particulate drug delivery systems for parenteral delivery of protein are presented and discussed. The challenge...... for incorporation of protein in particulate delivery systems is exemplified by water-in-oil emulsions....

  14. Nosocomial Transmission of Group B Streptococci Proven by Positive Environmental Culture

    Directory of Open Access Journals (Sweden)

    Amal Al-Maani

    2014-09-01

    Full Text Available Objective: Neonates usually acquire Group B streptococcal infection vertically from the maternal birth canal during delivery. In January 2010, a Group B streptococcal outbreak investigation was conducted in response to an increased number of clinical specimens from our neonatal intensive care unit. Methods: Microbiology laboratory records were reviewed to identify Group B streptococcal from specimens originating from the neonatal intensive care unit during December 2009 and January 2010. Patients from whom these specimens were collected were identified and their charts reviewed. Environmental samples to screen for Group B streptococcal were collected from the unit, clinical and environmental isolates were compared by pulsed field gel electrophoresis. Point prevalence screening was conducted twice before declaring the outbreak over. Results: Pulsed field gel electrophoresis patterns of three clinical strains from six patients were indistinguishable. One environmental strain was isolated from one of the patients monitor, and had identical pulsed field gel electrophoresis pattern to that of the three clinical strains. Infection control measures were implemented in the neonatal intensive care unit and follow-up point prevalence screening identified no new cases. Conclusions: Although poor infection control practice has been implicated in previous reports of nosocomial outbreaks of Group B streptococcal infection in neonatal intensive care units, our finding provides unique evidence that the environment can act as a reservoir of Group B streptococcal and play a key role in nosocomial transmission.

  15. [Parametrial hematoma after forceps delivery].

    Science.gov (United States)

    Winkler, M; Gans, A; Fendel, H

    1991-01-01

    We report on a large intraligamentous haematoma developed after low forceps delivery. The diagnosis was made from symptoms and signs, rectal examination, and sonographic findings. The haematoma was incised and clots were evacuated by laparotomy. The bleeding vessel could be ligated. The 31-year-old woman left our hospital on the 12th postoperative day.

  16. Software Build and Delivery Systems

    Energy Technology Data Exchange (ETDEWEB)

    Robey, Robert W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-07-10

    This presentation deals with the hierarchy of software build and delivery systems. One of the goals is to maximize the success rate of new users and developers when first trying your software. First impressions are important. Early successes are important. This also reduces critical documentation costs. This is a presentation focused on computer science and goes into detail about code documentation.

  17. Extracellular vesicles for drug delivery

    NARCIS (Netherlands)

    Vader, Pieter; Mol, Emma A; Pasterkamp, Gerard; Schiffelers, Raymond M

    2016-01-01

    Extracellular vesicles (EVs) are cell-derived membrane vesicles, and represent an endogenous mechanism for intercellular communication. Since the discovery that EVs are capable of functionally transferring biological information, the potential use of EVs as drug delivery vehicles has gained consider

  18. In vivo transdermal delivery of leuprolide using microneedles and iontophoresis.

    Science.gov (United States)

    Sachdeva, Vishal; Zhou, Yingcong; Banga, Ajay K

    2013-01-01

    The objective of this study was to investigate the use of iontophoresis and/or microneedles to enhance transdermal delivery of leuprolide acetate in vivo in hairless rats. Microporation was achieved using 500 μm long maltose microneedles and pore formation was confirmed using dye binding studies, histology studies, calcein imaging studies, pore permeability index calculation and trans-epidermal water loss measurement. Iontophoresis was performed using liquid reservoir patch with inbuilt silver wire electrode and a current density of 0.1 mA/cm2 was applied for 4 hours. Delivery studies were performed using microneedles and iontophoresis alone and in combination. Passive studies involving delivery through intact skin and injections of drug solution administered subcutaneously served as controls. Blood samples were collected at predetermined time points and plasma samples were analyzed for drug using ELISA. Significantly higher drug levels were detected at the end of 6 hours treatment by microneedles alone treatment (0.98 ± 0.08 ng/ml) as compared to passive (0.36 ± 0.22 ng/ml) delivery (p iontophoresis alone (3.47 ± 0.03 ng/ml) or by combination (3.54 ± 0.08 ng/ml) treatments as compared to microneedles alone treatment (p iontophoresis alone treatment, combination treatment resulted in faster drug delivery due to propulsion of the drug through the preformed micropores. In conclusion, the use of microneedles and/or iontophoresis seems promising for the transdermal delivery of peptide like leuprolide acetate.

  19. Brain matters: from environmental ethics to environmental neuroethics.

    Science.gov (United States)

    Cabrera, Laura Y; Tesluk, Jordan; Chakraborti, Michelle; Matthews, Ralph; Illes, Judy

    2016-02-15

    The ways in which humans affect and are affected by their environments have been studied from many different perspectives over the past decades. However, it was not until the 1970s that the discussion of the ethical relationship between humankind and the environment formalized as an academic discipline with the emergence of environmental ethics. A few decades later, environmental health emerged as a discipline focused on the assessment and regulation of environmental factors that affect living beings. Our goal here is to begin a discussion specifically about the impact of modern environmental change on biomedical and social understandings of brain and mental health, and to align this with ethical considerations. We refer to this focus as Environmental Neuroethics, offer a case study to illustrate key themes and issues, and conclude by offering a five-tier framework as a starting point of analysis.

  20. Strategic Points in Aquaponics

    Directory of Open Access Journals (Sweden)

    Ranka Junge

    2017-03-01

    Full Text Available Global environmental, social and economic challenges drive the need for new and improved solutions for food production and consumption. Food production within a sustainability corridor requires innovations exceeding traditional paradigms, acknowledging the complexity arising from sustainability. However, there is a lack of knowledge about how to direct further activities, to develop technologies as potential solutions for questions related to climate change, loss of soil fertility and biodiversity, scarcity of resources, and shortage of drinking water. One approach that promises to address these problems is controlled environment agriculture. Aquaponics (AP combines two technologies: recirculation aquaculture systems (RAS and hydroponics (plant production in water, without soil in a closed-loop system. One challenge to the development of this technology is the conversion of the toxic ammonium produced by the fish into nitrate, via bacteria in a biofilter, to provide nitrogen to the plants. However, as this Special Issue shows, there are many other challenges that need to be addressed if the goal of the technology is to contribute to more sustainable food production systems.

  1. Elements of environmental management

    National Research Council Canada - National Science Library

    Antweiler, Werner

    2014-01-01

    ... important area of expertise. This book is an interdisciplinary texbook that integrates corporate environmental strategy with environmental economics, environmental law, and environmental engineering...

  2. Mucus-penetrating nanoparticles for vaginal and gastrointestinal drug delivery

    Science.gov (United States)

    Ensign-Hodges, Laura

    A method that could provide more uniform and longer-lasting drug delivery to mucosal surfaces holds the potential to greatly improve the effectiveness of prophylactic and therapeutic approaches for numerous diseases and conditions, including sexually transmitted infections and inflammatory bowel disease. However, the body's natural defenses, including adhesive, rapidly cleared mucus linings coating nearly all entry points to the body not covered by skin, has limited the effectiveness of drug and gene delivery by nanoscale delivery systems. Here, we investigate the use of muco-inert mucus-penetrating nanoparticles (MPP) for improving vaginal and gastrointestinal drug delivery. Conventional hydrophobic nanoparticles strongly adhere to mucus, facilitating rapid clearance from the body. Here, we demonstrate that mucoadhesive polystyrene nanoparticles (conventional nanoparticles, CP) become mucus-penetrating in human cervicovaginal mucus (CVM) after pretreatment with sufficient concentrations of Pluronic F127. Importantly, the diffusion rate of large MPP did not change in F127 pretreated CVM, implying there is no affect on the native pore structure of CVM. Additionally, there was no increase in inflammatory cytokine release in the vaginal tract of mice after daily application of 1% F127 for one week. Importantly, HSV virus remains adherent in F127-pretreated CVM. Mucosal epithelia use osmotic gradients for fluid absorption and secretion. We hypothesized that hypotonically-induced fluid uptake could be advantageous for rapidly delivering drugs through mucus to the vaginal epithelium. We evaluated hypotonic formulations for delivering water-soluble drugs and for drug delivery with MPP. Hypotonic formulations markedly increased the rate at which drugs and MPP reached the epithelial surface. Additionally, hypotonic formulations greatly enhanced drug and MPP delivery to the entire epithelial surface, including deep into the vaginal folds (rugae) that isotonic formulations

  3. Delivery should happen soon and my pain will be reduced: understanding women's perception of good delivery care in India.

    Science.gov (United States)

    Bhattacharyya, Sanghita; Srivastava, Aradhana; Avan, Bilal Iqbal

    2013-11-22

    Understanding a woman's perspective and her needs during childbirth and addressing them as part of quality-improvement programmes can make delivery care safe, affordable, and respectful. It has been pointed out that the patient's judgement on the quality and goodness of care is indispensible to improving the management of healthcare systems. The objective of the study is to understand the aspects of care that women consider important during childbirth. Individual in-depth interviews (IDIs) and focus-group discussions (FGDs) with women who recently delivered were the techniques used. Seventeen IDIs and four FGDs were conducted in Jharkhand state in east India between January and March 2012. Women who had normal deliveries with live births at home and in primary health centres were included. To minimise recall bias, interviews were conducted within 42 days of childbirth. Using the transcripts of interviews, the data were analysed thematically. Aspects of care most commonly cited by women to be important were: availability of health providers and appropriate medical care (primarily drugs) in case of complications; emotional support; privacy; clean place after delivery; availability of transport to reach the institution; monetary incentives that exceed expenses; and prompt care. Other factors included kind interpersonal behaviour, cognitive support, faith in the provider's competence, and overall cleanliness of the facility and delivery room. Respondents belonging to low socio-economic strata with basic literacy levels might not understand appropriate clinical aspects of care, but they want care that is affordable and accessible, along with privacy and emotional support during delivery. The study highlighted that healthcare quality-improvement programmes in India need to include non-clinical aspects of care as women want to be treated humanely during delivery--they desire respectful treatment, privacy, and emotional support. Further research into maternal satisfaction

  4. Environmental Performance

    DEFF Research Database (Denmark)

    Svabo, Connie; Lindelof, Anja Mølle

    2017-01-01

    Presence, attention and awareness are challenged in a cultural landscape with an overflow of media and information (big data, mediatization processes), an overflow of time scheduling (rationalization, effectuation), and an overflow of marketing for example of ‘live performance’ as a promotional...... from the perspective of time and liveness as experienced in art on environmental performance discussing how environmental performances frame the temporality of the world. The paper engages with contemporary examples of environmental performances from various disciplines (sound, video, television......, performance art), and seeks to contribute to the ongoing debate on the quality and status of live performance (Reason & Lindelof 2016). As a critical response to the above mentioned overflows these performances make their own overflow through their characteristically non-representational, unpredictable...

  5. Environmental Tracers

    Directory of Open Access Journals (Sweden)

    Trevor Elliot

    2014-10-01

    Full Text Available Environmental tracers continue to provide an important tool for understanding the source, flow and mixing dynamics of water resource systems through their imprint on the system or their sensitivity to alteration within it. However, 60 years or so after the first isotopic tracer studies were applied to hydrology, the use of isotopes and other environmental tracers are still not routinely necessarily applied in hydrogeological and water resources investigations where appropriate. There is therefore a continuing need to promote their use for developing sustainable management policies for the protection of water resources and the aquatic environment. This Special Issue focuses on the robustness or fitness-for-purpose of the application and use of environmental tracers in addressing problems and opportunities scientifically, to promote their wider use and to address substantive issues of vulnerability, sustainability, and uncertainty in (groundwater resources systems and their management.

  6. Environmental teratogens.

    Science.gov (United States)

    Brent, R. L.; Beckman, D. A.

    1990-01-01

    By far the largest category of malformations, 65% falls into the group of those with an unknown cause(s). Purely genetic causes of malformations (autosomal and cytogenetic), estimated to produce 20 to 25% of all human malformations, comprise the largest group of congenital malformations with known etiology. Although environmental causes of human malformations account for 10% or fewer of malformations, most of these environmentally induced malformations are related to maternal disease states. Fewer than 1% of all human malformations are related to drug exposure, chemicals, or radiation, but studies of environmentally induced malformations are important because they may teach us how to predict and test for teratogenicity, understand the mechanisms of teratogenesis from all etiologies, and provide a means by which human malformations can be prevented. PMID:2194610

  7. Environmental teratogens

    Energy Technology Data Exchange (ETDEWEB)

    Brent, R.L.; Beckman, D.A. (Thomas Jefferson Univ., Philadelphia, PA (USA))

    1990-03-01

    By far the largest category of malformations, 65% falls into the group of those with an unknown cause(s). Purely genetic causes of malformations (autosomal and cytogenetic), estimated to produce 20 to 25% of all human malformations, comprise the largest group of congenital malformations with known etiology. Although environmental causes of human malformations account for 10% or fewer of malformations, most of these environmentally induced malformations are related to maternal disease states. Fewer than 1% of all human malformations are related to drug exposure, chemicals, or radiation, but studies of environmentally induced malformations are important because they may teach us how to predict and test for teratogenicity, understand the mechanisms of teratogenesis from all etiologies, and provide a means by which human malformations can be prevented.298 references.

  8. ATLAS Point 1 Construction

    CERN Multimedia

    Inigo-Golfin, J

    After 3 years of work in point 1, a number of surface buildings have already been completed and handed over to CERN (the control, the gas and the cooling and ventilation buildings) and, probably more appealing to the public, 60,000 m3 of earth have already been excavated from underground. At present, the technical cavern USA15 and its access shaft are almost finished, leaving only the main cavern and the liaison galleries to be completed in the coming year and a half. The main cavern has been excavated down to the radiation limit and its walls and vault will presently be concreted (see below the picture of the section of the vault with the impressive shell of 1.2 m thickness). The excavation of the bench (27 vertical metres to go yet!) will proceed from August, when some additional civil engineering work in the LHC tunnel will be undertaken. Needless to say many different services are necessary around the detector, both for its installation and future operation for physics. To that end much of the heavy...

  9. Point 1 Updates

    CERN Multimedia

    Inigo-Golfin, J.

    The ATLAS experimental area is located in Point 1, just across the main CERN entrance, in the commune of Meyrin. There people are ever so busy to finish the different infrastructures for ATLAS. Not only has Civil Engineering finished the construction of the USA15 technical cavern, but the excavation of the main UX15 cavern has resumed below the machine tunnel, after a brief halt to allow the construction of the UJ-caverns for the power converters of the LHC machine. The excavation work should end in August 2002. The UX15 hand-over to ATLAS is expected in April 2003. On the surface civil engineering is starting to complete the last two surface buildings (SDX1 and SH1), once the services (cooling pipes, ventilation ducts and the largest item, the lift modules and its lift of course) in the shaft PX15 have been completed. But the civil engineering is not all. A lot more is under way. The site installation of the steel structures in the caverns is to begin in Autumn, along with all the cooling pipes, airconditi...

  10. "Point de suspension"

    CERN Multimedia

    2004-01-01

    CERN - Globe of Science and Innovation 20 and 21 October Acrobatics, mime, a cappella singing, projections of images, a magical setting... a host of different tools of a grandeur matching that of the Universe they relate. A camera makes a massive zoom out to reveal the multiple dimensions of Nature. Freeze the frame: half way between the infinitesimally small and the infinitesimally large, a man suspends his everyday life (hence the title "Point de Suspension", which refers to the three dots at the end of an uncompleted sentence) to take a glimpse of the place he occupies in the great history of the Universe. An unusual perspective on what it means to be a human being... This spectacle in the Globe of Science and Innovation, specially created by the Miméscope* company for the official ceremony marking CERN's fiftieth anniversary, is a gift from the Government of the Republic and Canton of Geneva, which also wishes to share this moment of wonder with the local population. There will be three performances for...

  11. "Point de suspension"

    CERN Multimedia

    2004-01-01

    CERN - Globe of Science and Innovation 20 and 21 October Acrobatics, mime, a cappella singing, projections of images, a magical setting... a host of different tools of a grandeur matching that of the Universe they relate. A camera makes a massive zoom out to reveal the multiple dimensions of Nature. Freeze the frame: half way between the infinitesimally small and the infinitesimally large, a man suspends his everyday life (hence the title "Point de Suspension", which refers to the three dots at the end of an uncompleted sentence) to take a glimpse of the place he occupies in the great history of the Universe. An unusual perspective on what it means to be a human being... This wondrous show in the Globe of Science and Innovation, specially created by the Miméscope* company for the official ceremony marking CERN's fiftieth anniversary, is a gift from the Government of the Republic and Canton of Geneva, which also wishes to share this moment of wonder with the local population. There will be three perfo...

  12. "Point de suspension"

    CERN Multimedia

    2004-01-01

    http://www.cern.ch/cern50/ CERN - Globe of Science and Innovation 20 and 21 October Acrobatics, mime, a cappella singing, projections of images, a magical setting... a host of different tools of a grandeur matching that of the Universe they relate. A camera makes a massive zoom out to reveal the multiple dimensions of Nature. Freeze the frame: half way between the infinitesimally small and the infinitesimally large, a man suspends his everyday life (hence the title "Point de Suspension", which refers to the three dots at the end of an uncompleted sentence) to take a glimpse of the place he occupies in the great history of the Universe. An unusual perspective on what it means to be a human being... This wondrous show in the Globe of Science and Innovation, specially created by the Miméscope* company for the official ceremony marking CERN's fiftieth anniversary, is a gift from the Government of the Republic and Canton of Geneva, which also wishes to share this moment of wonder with the local pop...

  13. Electronic Nicotine Delivery Systems Key Facts Infographic

    Data.gov (United States)

    U.S. Department of Health & Human Services — Explore the Electronic Nicotine Delivery Systems Key Facts Infographic which outlines key facts related to electronic nicotine delivery systems (ENDS), including...

  14. After vaginal delivery - in the hospital

    Science.gov (United States)

    ... patientinstructions/000629.htm After vaginal delivery - in the hospital To use the sharing features on this page, ... enable JavaScript. Most women will remain in the hospital for 24 hours after delivery. This is important ...

  15. FastStats: Births -- Method of Delivery

    Science.gov (United States)

    ... this? Submit What's this? Submit Button NCHS Home Births - Method of Delivery Recommend on Facebook Tweet Share ... of all deliveries by Cesarean: 32.0% Source: Births: Final Data for 2015, table 21 [PDF - 1. ...

  16. Patient's Guide to Aerosol Drug Delivery

    Science.gov (United States)

    ... Table of Contents Page Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 ................................................................ 1. Aerosol Drug Delivery: The Basics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. Aerosol Drugs: The Major Categories . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .12 3. Aerosol Drug Delivery Devices: Small-Volume Nebulizers . . . . . . . . . . . . .17 4. Aerosol Drug ...

  17. Predictors of vaginal delivery in nulliparous mothers

    African Journals Online (AJOL)

    study. Vaginal delivery was achieved in 214 (74.8%) of the eligible parturient, while 72 (25.2%) had ..... Table 2: Logistic regression of factors influencing vaginal delivery in primigravidae ... times higher risk of emergency caesarean section.

  18. Sterile Product Packaging and Delivery Systems.

    Science.gov (United States)

    Akers, Michael J

    2015-01-01

    Both conventional and more advanced product container and delivery systems are the focus of this brief article. Six different product container systems will be discussed, plus advances in primary packaging for special delivery systems and needle technology.

  19. The Cultural Geography of Health Care Delivery.

    Science.gov (United States)

    Gesler, Wilbert M.

    1987-01-01

    This article shows how health care delivery is related to cultural or human geography. This is accomplished by describing health care delivery in terms of 12 popular themes of cultural geography. (JDH)

  20. Higher Throughput Maintenance Using Average Time Standard for Multipath Data Delivery Ad-hoc Network System

    Directory of Open Access Journals (Sweden)

    A.P.Shanmugasundaram

    2014-07-01

    Full Text Available Wireless network has come out as one of the key enablers for reliable data delivery for different types of applications.Ad-hoc network consists of self-actuated node that collaborates in order to transfer the information.Trajectory-based Statistical Forwarding (TSF method used optimal target point selection algorithm to forward packets in order to satisfy probability of packet delivery over multi-hopbut failed provide higher throughputon the multipath data delivery. TheVoid Aware Pressure Routing (VAPR method used hop count and intensity information to build a directional data delivery system but performance of specialized geographic routing based multipath data delivery was not attained. To maintain the higher throughput level on ad-hoc network data delivery, Median Multicast Throughput Data Delivery (MMTDD mechanism is proposed in thispaper.The basic idea of MMTDD mechanism is to divide a message into multiple shares and deliver them via multiple independent source paths to the destination. MMTDD mechanism with the average time standard takes the best threshold value for every data (i.e., packet partitioning by avoiding packet loss. By this means, MMTDD mechanism uses the Average Time Standard (ATS to guarantee the required packet allocationwith higher throughput level. With the application of ATS, the MMTDD mechanism derives the theoretical model by attaining approximately 4% higher throughput level on the multipath data delivery in ad-hoc network.MMTDD mechanism makes use of time scheduling schemestodiscover and maintain data delivery paths with minimal time consumption.Median Multicast in MMTDD mechanism used the balanced state flow model to deliver data on multiple paths and experiment is conducted on factors such as time consumption, data delivery rate,average delivery delay and throughput level.

  1. Oral delivery strategies for nutraceuticals: Delivery vehicles and absorption enhancers

    OpenAIRE

    Gleeson, John P.; Ryan, Sinéad M.; Braden, David James

    2016-01-01

    Lifestyle issues contribute to the development of obesity, type 2 diabetes, and cardiovascular disease. Together with appropriate diet and exercise, nutraceuticals may contribute to managing prevention at an early stage prior to therapeutic intervention. However, many useful food-derived bioactive compounds will not sufficiently permeate the small intestine to yield efficacy without appropriate oral delivery technology. The pharmaceutical industry uses commercialised approaches for oral deliv...

  2. Globalization and Environmental Education: Looking beyond sustainable development

    NARCIS (Netherlands)

    Jickling, B.; Wals, A.E.J.

    2008-01-01

    This study contends that environmental education is being significantly altered by globalizing forces, witnessing the effort to convert environmental education into education for sustainable development. This internationally propagated conversion can be challenged from many vantage points. This stud

  3. Hydrogels: a journey from diapers to gene delivery.

    Science.gov (United States)

    Chawla, Pooja; Srivastava, Alok Ranjan; Pandey, Priyanka; Chawla, Viney

    2014-02-01

    Hydrogels are the biomaterials comprising network of natural or synthetic polymers capable of absorbing large amount of water. Hydrogels are "Smart Gels" or "Intelligent Gels" which can be made to respond to the various environmental conditions like temperature, pH, magnetic/electric field, ionic strength, inflammation, external stress etc. There are numerous potential applications of hydrogels in modern day life ranging from a diaper to gene delivery. This review succinctly describes the classification, properties and preparation methods along with numerous diverse applications of hydrogels like agricultural hydrogels, hydrogel for drug delivery, sensing, dental adhesives, wound healing and tissue regeneration, diet aid and gastric retention and in tissue engineering etc. Hydrogels can be regarded as highly valuable biomaterials for human-beings.

  4. Lycopene from tomatoes: vesicular nanocarrier formulations for dermal delivery.

    Science.gov (United States)

    Ascenso, Andreia; Pinho, Sónia; Eleutério, Carla; Praça, Fabíola Garcia; Bentley, Maria Vitória Lopes Badra; Oliveira, Helena; Santos, Conceição; Silva, Olga; Simões, Sandra

    2013-07-31

    This experimental work aimed to develop a simple, fast, economic, and environmentally friendly process for the extraction of lycopene from tomato and incorporate this lycopene-rich extract into ultradeformable vesicular nanocarriers suitable for topical application. Lycopene extraction was conducted without a cosolvent for 30 min. The extracts were analyzed and incorporated in transfersomes and ethosomes. These formulations were characterized, and the cellular uptake was observed by confocal microscopy. Dermal delivery of lycopene formulations was tested under in vitro and in vivo conditions. Lycopene extraction proved to be quite safe and selective. The vesicular formulation was taken up by the cells, being more concentrated around the nucleus. Epicutaneous application of lycopene formulations decreased the level of anthralin-induced ear swelling by 97 and 87%, in a manner nonstatistically different from the positive control. These results support the idea that the lycopene-rich extract may be a good alternative to the expensive commercial lycopene for incorporation into advanced topical delivery systems.

  5. 基于Triton X-114的浊点法萃取富集环境水样中的双酚A%Cloud-point Extraction with Triton X-114 for Extraction and Preconcentration of Biphenol A from Environmental Water Samples

    Institute of Scientific and Technical Information of China (English)

    陶赛辉; 夏文斌

    2011-01-01

    目的 探讨TX-114浊点萃取体系应用于环境水样中萃取双酚A的实验过程,影响萃取的因素(如TX-114的浓度、平衡时间和温度、pH值等).方法 通过高效液相色谱测定样品的含量.结果 在最佳实验条件下,双酚A的检测限达到了0.05μg/L.在0.4-100μg/L浓度范围内,该方法具有良好的线性关系,相关系数为0.9987,加样回收率为97.96%~100.42%.结论 该法具有高效绿色环保以及成本低等特点,是一种萃取水样中双酚A的好方法.%Objective To explore the experimental process of cloud- point extraction (CPE) based on nonionic surfactant Triton X - 114 in preconcentration of biphenol A (BPA) from aqueous solutions, and the parameters affecting the CPE (such as concentration of TX- 114, equilibrium time and temperature, pH).Methods The samples were analyzed by high - performance liquid chromatography.Results Under the optimized conditions, its detection limit was 0.05 μg/L.The calibration curve was linear between 0.4 to 100 μg/L, the correlation coefficient was 0.9987, and the spiking recoveries ranged from 97.96 % to 100.42 %.Conclusions This method has proven to be an efficient, green environmental, rapid and inexpensive approach for extraction and determination of BPA from water samples.

  6. Environmental impacts of beef production: Review of challenges and perspectives for durability.

    Science.gov (United States)

    Gerber, Pierre J; Mottet, Anne; Opio, Carolyn I; Falcucci, Alessandra; Teillard, Félix

    2015-11-01

    Beef makes a substantial contribution to food security, providing protein, energy and also essential micro-nutrients to human populations. Rumination allows cattle - and other ruminant species - to digest fibrous feeds that cannot be directly consumed by humans and thus to make a net positive contribution to food balances. This contribution is of particular importance in marginal areas, where agro-ecological conditions and weak infrastructures do not offer much alternative. It is also valuable where cattle convert crop residues and by-products into edible products and where they contribute to soil fertility through their impact on nutrients and organic matter cycles. At the same time, environmental sustainability issues are acute. They chiefly relate to the low efficiency of beef cattle in converting natural resources into edible products. Water use, land use, biomass appropriation and greenhouse gas emissions are for example typically higher per unit of edible product in beef systems than in any other livestock systems, even when corrected for nutritional quality. This particularly causes environmental pressure when production systems are specialized towards the delivery of edible products, in large volumes. The paper discusses environmental challenges at global level, recognizing the large diversity of systems. Beef production is faced with a range of additional sustainability challenges, such as changing consumer perceptions, resilience to climate change, animal health and inequities in access to land and water resources. Entry-points for environmental sustainability improvement are discussed within this broader development context.

  7. Osteogenesis imperfecta: cesarean deliveries in identical twins.

    Science.gov (United States)

    Dinges, E; Ortner, C; Bollag, L; Davies, J; Landau, R

    2015-02-01

    Osteogenesis imperfecta is a congenital disorder resulting in multiple fractures and extremely short stature, usually necessitating cesarean delivery. Identical twins with severe osteogenesis imperfecta each of whom underwent a cesarean delivery with different anesthetic modalities are presented. A review of the literature and anesthetic options for cesarean delivery and postoperative analgesia for women with osteogenesis imperfecta are discussed.

  8. Time Slot Management in Attended Home Delivery

    NARCIS (Netherlands)

    M.W.P. Savelsbergh (Martin); M. Fleischmann (Moritz); N.A.H. Agatz (Niels); A.M. Campbell (Ann Melissa)

    2011-01-01

    textabstractMany e-tailers providing attended home delivery, especially e-grocers, offer narrow delivery time slots to ensure satisfactory customer service. The choice of delivery time slots has to balance marketing and operational considerations, which results in a complex planning problem. We

  9. Time Slot Management in Attended Home Delivery

    NARCIS (Netherlands)

    N.A.H. Agatz (Niels); A.M. Campbell (Ann Melissa); M. Fleischmann (Moritz); M.W.P. Savelsbergh (Martin)

    2008-01-01

    textabstractMany e-tailers providing attended home delivery, especially e-grocers, offer narrow delivery time slots to ensure satisfactory customer service. The choice of delivery time slots has to balance marketing and operational considerations, which results in a complex planning problem. We

  10. Carbon Break Even Analysis: Environmental Impact of Tablets in Higher Education

    Directory of Open Access Journals (Sweden)

    Fadi Safieddine

    2016-05-01

    Full Text Available With the growing pace of tablets use and the large focus it is attracting especially in higher education, this paper looks at an important aspect of tablets; their carbon footprint. Studies have suggested that tablets have positive impact on the environment; especially since tablets use less energy than laptops or desktops. Recent manufacturers’ reports on the carbon footprint of tablets have revealed that a significant portion, as much as 80%, of the carbon footprint of tablets comes from production and delivery as opposed to the operational life-cycle of these devices. Thus rending some of previous assumptions about the environmental impact of tablets questionable. This study sets to answer a key question: What is the break-even analysis point when saving on printed paper offsets the carbon footprint of producing and running the tablet in higher education. A review of the literature indicated several examples of tablet models and their carbon emission impact; this is compared to the environmental savings on paper that green courses could produce. The analysis of the carbon break-even point shows that even when considering some of the most efficient and least carbon impact tablets available on the market with a carbon-footprint production of 153Kg CO2e, the break-even point is 81.5 months; referring to 6 years, 9 months and 15 days of use. This exceeds the life-cycle of an average tablet of five years and average degree duration of four years. While tablets still have the least carbon-footprint impact compared to laptops and desktops, to achieve the break-even point of carbon neutral operations this study concludes that manufacturers need to find more environmentally efficient ways of production that would reduce the carbon-footprint product to a level that does not exceed 112.8kg CO2e.

  11. Festive environmentalism

    DEFF Research Database (Denmark)

    Olwig, Mette Fog; Christiansen, Lene Bull

    2016-01-01

    Mikhail Bakhtin’s idea of the carnivalesque is applied here to a case study of eco-voluntourism at the Roskilde Festival, an international culture and music event held in Denmark. In the literature on popular forms of environmentalism a dichotomy between engaging and educating about the political...... a venue for both to be stimulated....

  12. ENVIRONMENTAL GEOLOGY

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    20160639Cai Wutian(Center for Hydrogeology a nd Environmental Geology Survey,China Geological Survey,Baoding071051,China)Several Issues on Contaminated Sites(Hydrogeology and Engineering Geology,ISSN1000-3665,CN11-2202/P,42(1),2015,p.123

  13. Environmental sciences

    NARCIS (Netherlands)

    Kwa, C.; Wright, J.D.

    2015-01-01

    The environmental sciences are engaged in a remarkable effort of interdisciplinary cooperation and integration. Some long-running international scientific programs, notably the World Climate Research Programme and the International Geosphere-Biosphere Programme, play an important role therein. The o

  14. Environmental sciences

    NARCIS (Netherlands)

    Kwa, C.; Wright, J.D.

    2015-01-01

    The environmental sciences are engaged in a remarkable effort of interdisciplinary cooperation and integration. Some long-running international scientific programs, notably the World Climate Research Programme and the International Geosphere-Biosphere Programme, play an important role therein. The o

  15. ENVIRONMENTAL GEOLOGY

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>20040834 Chen Yijiu (Geological Exploration Bureau of Guangdong Province, Guangzhou, Guangdong) Discussion on Natural Chornic Irradiation Environment and Pertinent Problems in Guangdong Province, China (Guangdong Geology, ISSN 1001 - 8670, CN44-1201/P, 18(1), 2003, p. 30-41, 7 tables, 1 ref. , with English abstract) Keywords: radioactivity radiation environmental pollution Guangdong Province

  16. Environmental communication research in Finland; Ympaeristoeviestinnaen tutkimus Suomessa

    Energy Technology Data Exchange (ETDEWEB)

    Lyytimaeki, J.; Palosaari, M.

    2004-07-01

    This report presents Finnish research on environmental communication and describes different was of understanding the term environmental communication. The objective of the report is to indicate relevant topics for future research in environmental communication from the point of view of environmental policy research and Finnish environmental administration. The report outlines the development of environmental journalism from the 1960's till present and explores the different approaches taken in researching environmental communication. Or organisation and crisis communication, sociology, environmental education and policy are current y the fields of science most active in environmental communication research. Visuality of communication and the effects of new information technology are increasingly interesting phenomena for the study of environmental communication. This report points out needs of research from each of these fields. The report includes also a bibliography of environmental communication research in Finland. (orig.)

  17. The milk delivery chain and presence of Brucella spp. antibodies in bulk milk in Uganda.

    Science.gov (United States)

    Rock, Kim Toeroek; Mugizi, Denis Rwabiita; Ståhl, Karl; Magnusson, Ulf; Boqvist, Sofia

    2016-06-01

    This study examined the influence of informal milk delivery chains on the risk of human exposure to Brucella spp. through milk consumption in two regions of Uganda (Gulu and Soroti Districts). The work involved describing milk delivery chains, investigating brucellosis awareness amongst milk deliverers and determining the presence of Brucella spp. antibodies in cattle milk on delivery to primary collection points (boiling points and dairies). Milk samples (n = 331) were collected from deliverers at primary collection points and from street vendors at point of sale and analysed using indirect enzyme-linked immunosorbent assay (I-ELISA). A written questionnaire was used to collect data from deliverers (n = 279) on their milk delivery chains and their brucellosis awareness. The most common delivery points in Gulu District were small dairies and in Soroti District boiling points. The presence of Brucella spp. antibodies in milk samples was higher in Soroti (40 %) than in Gulu (11 %) (P < 0.0001). There are possible public health risk consequences of this finding as 42 % of deliverers in Soroti District reported drinking raw milk, compared with 15 % in Gulu District (P < 0.0001). Awareness of brucellosis was low, with 70 % of all milk deliverers reporting not having heard of the disease or the bacterium. Application of quality controls for milk (colour and odour) along the delivery chain varied depending upon supply and demand. This study provides evidence of the diversity of informal milk markets in low-income countries and of the potential public health risks of consuming unpasteurised milk. These results can be useful to those planning interventions to reduce brucellosis.

  18. Noninvasive measurement of transdermal drug delivery by impedance spectroscopy

    Science.gov (United States)

    Arpaia, Pasquale; Cesaro, Umberto; Moccaldi, Nicola

    2017-01-01

    The effectiveness in transdermal delivery of skin permeation strategies (e.g., chemical enhancers, vesicular carrier systems, sonophoresis, iontophoresis, and electroporation) is poorly investigated outside of laboratory. In therapeutic application, the lack of recognized techniques for measuring the actually-released drug affects the scientific concept itself of dosage for topically- and transdermally-delivered drugs. Here we prove the suitability of impedance measurement for assessing the amount of drug penetrated into the skin after transdermal delivery. In particular, the measured amount of drug depends linearly on the impedance magnitude variation normalized to the pre-treated value. Three experimental campaigns, based on the electrical analysis of the biological tissue behavior due to the drug delivery, are reported: (i) laboratory emulation on eggplants, (ii) ex-vivo tests on pig ears, and finally (iii) in-vivo tests on human volunteers. Results point out that the amount of delivered drug can be assessed by reasonable metrological performance through a unique measurement of the impedance magnitude at one single frequency. In particular, in-vivo results point out sensitivity of 23 ml−1, repeatability of 0.3%, non-linearity of 3.3%, and accuracy of 5.7%. Finally, the measurement resolution of 0.20 ml is compatible with clinical administration standards. PMID:28338008

  19. Exceptional Points and Dynamical Phase Transitions

    Directory of Open Access Journals (Sweden)

    I. Rotter

    2010-01-01

    Full Text Available In the framework of non-Hermitian quantum physics, the relation between exceptional points,dynamical phase transitions and the counter intuitive behavior of quantum systems at high level density is considered. The theoretical results obtained for open quantum systems and proven experimentally some years ago on a microwave cavity, may explain environmentally induce deffects (including dynamical phase transitions, which have been observed in various experimental studies. They also agree(qualitatively with the experimental results reported recently in PT symmetric optical lattices.

  20. Modelling occupants’ heating set-point prefferences

    DEFF Research Database (Denmark)

    Andersen, Rune Vinther; Olesen, Bjarne W.; Toftum, Jørn

    2011-01-01

    consumption. Simultaneous measurement of the set-point of thermostatic radiator valves (trv), and indoor and outdoor environment characteristics was carried out in 15 dwellings in Denmark in 2008. Linear regression was used to infer a model of occupants’ interactions with trvs. This model could easily......Discrepancies between simulated and actual occupant behaviour can offset the actual energy consumption by several orders of magnitude compared to simulation results. Thus, there is a need to set up guidelines to increase the reliability of forecasts of environmental conditions and energy...

  1. The computed cranial focal point

    NARCIS (Netherlands)

    Jong, G.A. de; Maal, T.J.J.; Delye, H.

    2015-01-01

    INTRODUCTION: Stereophotogrammetry is a radiation-free method for monitoring skull development after craniosynostosis repair. Lack of clear fixed reference points complicate longitudinal comparison of 3D photographs. Therefore we developed the 'computed cranial focal point' (CCFP). METHODS: The CCFP

  2. Environmental Ethics and Civil Engineering.

    Science.gov (United States)

    Vesilind, P. Aarne

    1987-01-01

    Traces the development of the civil engineering code of ethics. Points out that the code does have an enforceable provision that addresses the engineer's responsibility toward the environment. Suggests revisions to the code to accommodate the environmental impacts of civil engineering. (TW)

  3. Environmental Contamination of Normal Speech.

    Science.gov (United States)

    Harley, Trevor A.

    1990-01-01

    Environmentally contaminated speech errors (irrelevant words or phrases derived from the speaker's environment and erroneously incorporated into speech) are hypothesized to occur at a high level of speech processing, but with a relatively late insertion point. The data indicate that speech production processes are not independent of other…

  4. Environmental Impact Analysis Process. Environmental Assessment for Space Division Proposed Housing, White Point, San Pedro, California

    Science.gov (United States)

    1984-07-01

    efficient construction, including attic and wall insulation, and reduced glass areas; 0 Energy-efficient electrical equipment, such as fluores - cent...soapstone objects is particularly significant. The subsistence base was diverse including acorns, chia (sage seeds), wild fruits, large and I a small

  5. Leukocyte set points in metabolic disease.

    Science.gov (United States)

    Odegaard, Justin I; Chawla, Ajay

    2012-01-01

    Vertebrate tissues comprise precise admixtures of parenchymal and hematopoietic cells, whose interactions are vital to proper tissue function. By regulating this interaction, vertebrates are able to mitigate environmental stress and coordinate dramatic physiologic adaptations. For instance, under conditions of chronic nutrient excess, leukocyte recruitment and activation increase in an effort to decrease excess nutrient storage and alleviate adipocyte stress. While basal equilibria may be reestablished upon normalization of nutrient intake, a new set point characterized by insulin resistance and chronic inflammation is established if the stress persists. Consequently, although this response is adaptive in settings of acute overfeeding and infection, it has catastrophic health consequences in the modern context of obesity. Understanding how leukocyte set points (numbers and activation status) are established, maintained, and regulated in tissues is, thus, critical to our understanding of, and intervention in, chronic metabolic diseases, such as obesity and diabetes.

  6. Quaternary Tipping Points in Tropical Northern Australia

    Science.gov (United States)

    Moss, Patrick; Dunbar, Gavin; Croke, Jacky; Katunar, Rosie

    2016-04-01

    Tropical northern Queensland, particularly the volcanic Atherton Tableland, contains some of the most detailed and longest terrestrial palaeoenvironmental archives in Australia and when combined with adjacent marine sediment records provides key insight into potential environmental 'tipping points' for the entire Quaternary period and beyond. This presentation will provide an overview of some of the key tipping points (i.e. significant landscape transformation) that have occurred within the tropical northern Australian region over the Quaternary, as well as discussing potential causes and subsequent impacts of these transformation episodes. These events include the development of the Great Barrier Reef, transition from obliquity to eccentricity dominated glacial-interglacial cycles, the Mid-Brunhes event, the Oxygen Isotope Stage 6 episode, the arrival of people into the region, Last Glacial-Interglacial Transition and European settlement.

  7. Population-level correlates of preterm delivery among black and white women in the U.S.

    Directory of Open Access Journals (Sweden)

    Suzan L Carmichael

    Full Text Available OBJECTIVE: This study examined the ability of social, demographic, environmental and health-related factors to explain geographic variability in preterm delivery among black and white women in the US and whether these factors explain black-white disparities in preterm delivery. METHODS: We examined county-level prevalence of preterm delivery (20-31 or 32-36 weeks gestation among singletons born 1998-2002. We conducted multivariable linear regression analysis to estimate the association of selected variables with preterm delivery separately for each preterm/race-ethnicity group. RESULTS: The prevalence of preterm delivery varied two- to three-fold across U.S. counties, and the distributions were strikingly distinct for blacks and whites. Among births to blacks, regression models explained 46% of the variability in county-level risk of delivery at 20-31 weeks and 55% for delivery at 32-36 weeks (based on R-squared values. Respective percentages for whites were 67% and 71%. Models included socio-environmental/demographic and health-related variables and explained similar amounts of variability overall. CONCLUSIONS: Much of the geographic variability in preterm delivery in the US can be explained by socioeconomic, demographic and health-related characteristics of the population, but less so for blacks than whites.

  8. Nanoparticle Delivery Enhancement With Acoustically Activated Microbubbles

    Science.gov (United States)

    Mullin, Lee B; Phillips, Linsey C; Dayton, Paul A

    2013-01-01

    The application of microbubbles and ultrasound to deliver nanoparticle carriers for drug and gene delivery is an area that has expanded greatly in recent years. Under ultrasound exposure, microbubbles can enhance nanoparticle delivery by increasing cellular and vascular permeability. In this review, the underlying mechanisms of enhanced nanoparticle delivery with ultrasound and microbubbles and various proposed delivery techniques are discussed. Additionally, types of nanoparticles currently being investigated in preclinical studies, as well as the general limitations and benefits of a microbubble-based approach to nanoparticle delivery are reviewed. PMID:23287914

  9. Drug delivery device including electrolytic pump

    KAUST Repository

    Foulds, Ian G.

    2016-03-31

    Systems and methods are provided for a drug delivery device and use of the device for drug delivery. In various aspects, the drug delivery device combines a “solid drug in reservoir” (SDR) system with an electrolytic pump. In various aspects an improved electrolytic pump is provided including, in particular, an improved electrolytic pump for use with a drug delivery device, for example an implantable drug delivery device. A catalytic reformer can be incorporated in a periodically pulsed electrolytic pump to provide stable pumping performance and reduced actuation cycle.

  10. Solving discrete zero point problems

    NARCIS (Netherlands)

    van der Laan, G.; Talman, A.J.J.; Yang, Z.F.

    2004-01-01

    In this paper an algorithm is proposed to .nd a discrete zero point of a function on the collection of integral points in the n-dimensional Euclidean space IRn.Starting with a given integral point, the algorithm generates a .nite sequence of adjacent integral simplices of varying dimension and termi

  11. Magic Pointing for Eyewear Computers

    DEFF Research Database (Denmark)

    Jalaliniya, Shahram; Mardanbegi, Diako; Pederson, Thomas

    2015-01-01

    In this paper, we propose a combination of head and eye movements for touchlessly controlling the "mouse pointer" on eyewear devices, exploiting the speed of eye pointing and accuracy of head pointing. The method is a wearable computer-targeted variation of the original MAGIC pointing approach...

  12. Magic Pointing for Eyewear Computers

    DEFF Research Database (Denmark)

    Jalaliniya, Shahram; Mardanbegi, Diako; Pederson, Thomas

    2015-01-01

    In this paper, we propose a combination of head and eye movements for touchlessly controlling the "mouse pointer" on eyewear devices, exploiting the speed of eye pointing and accuracy of head pointing. The method is a wearable computer-targeted variation of the original MAGIC pointing approach...

  13. Clinical Application of Point Diji

    Institute of Scientific and Technical Information of China (English)

    栾继萍

    2004-01-01

    @@ Diji (SP 8) is a cleft point of the Spleen Channel of Foot-Taiyang. Its indications include abdominal pain, diarrhea, edema, dysmenorrhea and certain other symptoms caused by incoordination between the liver and the spleen. Either taking the point alone or together with some other adjunct points in clinical practice, the author has obtained satisfactory curative effects.

  14. A REVIEW ON OSMOTIC DRUG DELIVERY SYSTEM

    Directory of Open Access Journals (Sweden)

    Harnish Patel

    2012-04-01

    Full Text Available Conventional oral drug delivery systems supply an instantaneous release of drug, which cannot control the release of the drug and effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled pattern over a long period of time by the process of osmosis. Osmotic devices are the most promising strategy based systems for controlled drug delivery. They are the most reliable controlled drug delivery systems and could be employed as oral drug delivery systems. Various patents available for osmotic drug delivery system like Rose-Nelson pump, Higuchi leeper pump, Higuchi Theeuwes pump, Elementary Osmotic pump etc. ODDS are useful for poorly soluble drug, for pulsatile drug release, zero order release. Various techniques available for preparation of ODDS include push pull osmotic Pump, osmotic Brusting osmotic pump, liquid oral osmotic system, sandwiched osmotic tablets , delayed delivery osmotic device, monolithic osmotic System and controlled porosity osmotic Pump. Osmotically controlled oral drug delivery systems utilize osmotic pressure for controlled delivery of active agents. These systems can be utilized for systemic as well as targeted delivery of drugs. The release of drugs from osmotic systems is governed by various formulation factors such as solubility and osmotic pressure of the core components, size of the delivery orifice, and nature of the rate-controlling membrane. In this Paper mainly focused on the Osmotic System with example, the basic component of osmotic system and evaluation parameter of the osmotic drug delivery system.

  15. Creating the Nurses' Environmental Awareness Tool (NEAT).

    Science.gov (United States)

    Schenk, Elizabeth; Butterfield, Patricia; Postma, Julie; Barbosa-Leiker, Celestina; Corbett, Cindy

    2015-09-01

    Acute care delivery creates secondary health risks to patients, health care workers, and the environment through a complex waste stream, intensive energy use, and frequent use of harmful chemicals. Nurses are among the most affected by these risks and are also pivotal change agents in reducing the negative impacts of health care delivery. Assessing nurses' understanding of health care-associated environmental health risks is essential if care is to be delivered in an environmentally safe and healthy manner, as indicated by published professional standards of nursing practice. However, psychometrically sound instruments that measure nurses' awareness of the environmental impacts of nursing practice are not available. To address this gap, a prototype of the Nurse's Environmental Awareness Tool (NEAT) was developed. Seven content experts in environmental health nursing and/or psychometrics were asked to review draft items. Comments were analyzed and applied to the scale items. Several revisions from the original item pool were made. The resulting draft NEAT includes six subscales, in three paired subsets. This article provides a summary of the process of item development and scale design. These findings, although preliminary, provide a foundation for subsequent psychometric testing. The result of this study is the creation of an instrument to measure nurses' awareness of and behaviors associated with the environmental impact of their practices. © 2015 The Author(s).

  16. Functionalized bimodal mesoporous silicas as carriers for controlled aspirin delivery

    Science.gov (United States)

    Gao, Lin; Sun, Jihong; Li, Yuzhen

    2011-08-01

    The bimodal mesoporous silica modified with 3-aminopropyltriethoxysilane was performed as the aspirin carrier. The samples' structure, drug loading and release profiles were characterized with X-ray diffraction, scanning electron microscopy, N 2 adsorption and desorption, Fourier transform infrared spectroscopy, TG analysis, elemental analysis and UV-spectrophotometer. For further exploring the effects of the bimodal mesopores on the drug delivery behavior, the unimodal mesoporous material MCM-41 was also modified as the aspirin carrier. Meantime, Korsmeyer-Peppas equation ft= ktn was employed to analyze the dissolution data in details. It is indicated that the bimodal mesopores are beneficial for unrestricted drug molecules diffusing and therefore lead to a higher loading and faster releasing than that of MCM-41. The results show that the aspirin delivery properties are influenced considerably by the mesoporous matrix, whereas the large pore of bimodal mesoporous silica is the key point for the improved controlled-release properties.

  17. Experimentation in family planning delivery systems: an overview.

    Science.gov (United States)

    Cuca, R; Pierce, C S

    1977-12-01

    Experiments in the delivery of family planning services are an important means of testing new approaches on a relatively small scale. Over the past 20 years, extensive experimental efforts have explored such key aspects of service delivery as personnel, the use of mass media, integration of family planning with other services, intensive efforts and camps, incentive payments to acceptors, and inudation or community-based distribution. Approaches that proved successful have often been incorporated into regular programs. An examination of the methodology and findings of family planning experiments, based on a survey of 96 projects testing various approaches, highlights successes, failures, and continuing problems. The discussion of past experience halps point to criteria that might be followed in formulating future experimental projects.

  18. Spermbots: potential impact for drug delivery and assisted reproductive technologies.

    Science.gov (United States)

    Magdanz, Veronika; Schmidt, Oliver G

    2014-08-01

    Micromotors and nanomotors are an emerging research field that aims at achieving locomotion on the microscale for a variety of applications such as drug delivery, single cell manipulation, microsensors and lab-on-a-chip devices, just to point out a few. The enthusiastic development of hybrid micromotors harnessing biological power sources for physiologically compatible nano/microdevices has recently brought a lot of attention to the international research community that is looking for a solution for the actuation and locomotion on the microscale. This article describes the potential of sperm-driven micro-bio-robots in the biomedical field such as drug delivery or single cell manipulation. Herein, a specific potential of the sperm-driven micro-bio-robot is described that might have impact on the development of assisted reproductive technologies.

  19. Characterizing fluidic seals for on-board reagent delivery

    Science.gov (United States)

    Inamdar, Tejas; Anthony, Brian W.

    2013-03-01

    The reagent delivery mechanism in a point-of-care, HIV diagnostic, microfluidic device is studied. Reagents held in an aluminum blister pack are released on the opening of a fluidic seal. The fluidic seals, controlling the flow of reagents, are characterized to reduce anomalies in the desired flow pattern. The findings of this research can be divided into three categories - 1) bonding phenomenon 2) influence of seal pattern on flow and rupture mechanics and 3) process parameters which minimize flow anomalies. Four seal patterns - line hemisphere, line flat, chevron hemisphere and chevron flat were created and tested for reagent delivery using a flow sensor and a force gauge. Experiments suggest that one of the patterns - line-flat - inducted the fewest flow anomalies. A parameter scoping exercise of the seal manufacturing process parameters (temperature, time, pressure) was performed for the line flat seal. Temperature, time, pressure / gap and distance settings which minimize flow anomalies were found.

  20. Robotic Delivery of Complex Radiation Volumes for Small Animal Research.

    Science.gov (United States)

    Matinfar, Mohammad; Iordachita, Iulian; Wong, John; Kazanzides, Peter

    2010-07-15

    The Small Animal Radiation Research Platform (SARRP) is a novel and complete system capable of delivering multidirectional (focal), kilo-voltage radiation fields to targets in small animals under robotic control using cone-beam CT (CBCT) image guidance. The capability of the SARRP to deliver highly focused beams to multiple animal models provides new research opportunities that more realistically bridge laboratory research and clinical translation. This paper describes the design and operation of the SARRP for precise radiation delivery. Different delivery procedures are presented which enable the system to radiate through a series of points, representative of a complex shape. A particularly interesting case is shell dose irradiation, where the goal is to deliver a high dose of radiation to the shape surface, with minimal dose to the shape interior. The ability to deliver a dose shell allows mechanistic research of how a tumor interacts with its microenvironment to sustain its growth and lead to its resistance or recurrence.

  1. Incidence of Incisional Hernia after Cesarean Delivery

    DEFF Research Database (Denmark)

    Aabakke, Anna J M; Krebs, Lone; Ladelund, Steen

    2014-01-01

    OBJECTIVE: To estimate the incidence of incisional hernias requiring surgical repair after cesarean delivery over a 10-year period. METHODS: This population- and register-based cohort study identified all women in Denmark with no history of previous abdominal surgery who had a cesarean delivery...... between 1991 and 2000. The cohort was followed from their first until 10 years after their last cesarean delivery within the inclusion period or until the first of the following events: hernia repair, death, emigration, abdominal surgery, or cesarean delivery after the inclusion period. For women who had...... a hernia repair, hospital records regarding the surgery and previous cesarean deliveries were tracked and manually analyzed to validate the relationship between hernia repair and cesarean delivery. Data were analyzed with a competing risk analysis that included each cesarean delivery. RESULTS: We...

  2. Delivery Time Reliability Model of Logistics Network

    Directory of Open Access Journals (Sweden)

    Liusan Wu

    2013-01-01

    Full Text Available Natural disasters like earthquake and flood will surely destroy the existing traffic network, usually accompanied by delivery delay or even network collapse. A logistics-network-related delivery time reliability model defined by a shortest-time entropy is proposed as a means to estimate the actual delivery time reliability. The less the entropy is, the stronger the delivery time reliability remains, and vice versa. The shortest delivery time is computed separately based on two different assumptions. If a path is concerned without capacity restriction, the shortest delivery time is positively related to the length of the shortest path, and if a path is concerned with capacity restriction, a minimax programming model is built to figure up the shortest delivery time. Finally, an example is utilized to confirm the validity and practicality of the proposed approach.

  3. Monitoring some environmental impacts of oil industry on coastal zone using different remotely sensed data

    Directory of Open Access Journals (Sweden)

    M.N. Hegazy

    2010-06-01

    Various environmental parameters which might be affected by pollution resulting from activities related to the oil industry were identified and hot spots that might be subjected to environmental deterioration were pointed out for immediate measures for environmental protection.

  4. A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine.

    Science.gov (United States)

    Jahangirian, Hossein; Lemraski, Ensieh Ghasemian; Webster, Thomas J; Rafiee-Moghaddam, Roshanak; Abdollahi, Yadollah

    2017-01-01

    This review discusses the impact of green and environmentally safe chemistry on the field of nanotechnology-driven drug delivery in a new field termed "green nanomedicine". Studies have shown that among many examples of green nanotechnology-driven drug delivery systems, those receiving the greatest amount of attention include nanometal particles, polymers, and biological materials. Furthermore, green nanodrug delivery systems based on environmentally safe chemical reactions or using natural biomaterials (such as plant extracts and microorganisms) are now producing innovative materials revolutionizing the field. In this review, the use of green chemistry design, synthesis, and application principles and eco-friendly synthesis techniques with low side effects are discussed. The review ends with a description of key future efforts that must ensue for this field to continue to grow.

  5. ENVIRONMENTAL GEOLOGY

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正>20070678 Cao Wenbing (Beijing Key Laboratory of Water Resources and Environmental Engineering, China University of Geosciences, Beijing 100083, China); Wan Li Impacts of Global Warming on the Eco-Environment in the Headwater Region of the Yellow River (Earth Science Frontiers, ISSN1005-2321, CN11-3370, 13(1), 2006, p.40-47, 4 illus., 1 table, 5 refs.) Key words: habitat, global warming, Yellow River

  6. ENVIRONMENTAL GEOLOGY

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>20141810 Bian Yumei(Geological Environmental Monitoring Center of Liaoning Province,Shenyang 110032,China);Zhang Jing Zoning Haicheng,Liaoning Province,by GeoHazard Risk and Geo-Hazard Assessment(Journal of Geological Hazards and Environment Preservation,ISSN1006-4362,CN51-1467/P,24(3),2013,p.5-9,2 illus.,tables,refs.)

  7. Environmental factors

    Science.gov (United States)

    Michel, E. L.; Waligora, J. M.; Horrigan, D. J.; Shumate, W. H.

    1975-01-01

    The selection of an Apollo spacecraft atmosphere was based on the establishment of an acceptable range of atmospheric composition and pressure, the establishment of acceptable carbon dioxide levels, thermal comfort criteria, and acceleration and impact limits. The prime design requirements in a spacecraft system are minimum weight, volume, power usage, reliability, ease of maintenance, environmental compatibility, integration with other systems, and crew compatibility. The selection considerations are reviewed.

  8. Ground point filtering of UAV-based photogrammetric point clouds

    Science.gov (United States)

    Anders, Niels; Seijmonsbergen, Arie; Masselink, Rens; Keesstra, Saskia

    2016-04-01

    Unmanned Aerial Vehicles (UAVs) have proved invaluable for generating high-resolution and multi-temporal imagery. Based on photographic surveys, 3D surface reconstructions can be derived photogrammetrically so producing point clouds, orthophotos and surface models. For geomorphological or ecological applications it may be necessary to separate ground points from vegetation points. Existing filtering methods are designed for point clouds derived using other methods, e.g. laser scanning. The purpose of this paper is to test three filtering algorithms for the extraction of ground points from point clouds derived from low-altitude aerial photography. Three subareas were selected from a single flight which represent different scenarios: 1) low relief, sparsely vegetated area, 2) low relief, moderately vegetated area, 3) medium relief and moderately vegetated area. The three filtering methods are used to classify ground points in different ways, based on 1) RGB color values from training samples, 2) TIN densification as implemented in LAStools, and 3) an iterative surface lowering algorithm. Ground points are then interpolated into a digital terrain model using inverse distance weighting. The results suggest that different landscapes require different filtering methods for optimal ground point extraction. While iterative surface lowering and TIN densification are fully automated, color-based classification require fine-tuning in order to optimize the filtering results. Finally, we conclude that filtering photogrammetric point clouds could provide a cheap alternative to laser scan surveys for creating digital terrain models in sparsely vegetated areas.

  9. Imaging study on acupuncture points

    Energy Technology Data Exchange (ETDEWEB)

    Yan, X H; Zhang, X Y [Synchrotron Radiation Research Center, Physics Department, and Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China); Liu, C L [Physics Department of Yancheng Teachers College, Yancheng 224002 (China); Dang, R S [Second Military Medical University, Shanghai 200433 (China); Ando, M [DDS center, Research Institute for Science and Technology, Tokyo University of Science, Yamasaki 2541, Noda, Chiba 278-8510 (Japan); Sugiyama, H [Photon Factory, Institute of Material Structure Science, High Energy Accelerator Research Organization, Oho 1-1, Tsukuba, Ibaraki 305-0801 (Japan); Chen, H S [Institute of Modern Physics, Fudan University, Shanghai 200433 (China); Ding, G H, E-mail: xy-zhang@fudan.edu.c [Shanghai Research Center of Acupuncture and Meridian, Shanghai 201203 (China)

    2009-09-01

    The topographic structures of acupuncture points were investigated by using the synchrotron radiation based Dark Field Image (DFI) method. Four following acupuncture points were studied: Sanyinjiao, Neiguan, Zusanli and Tianshu. We have found that at acupuncture point regions there exists the accumulation of micro-vessels. The images taken in the surrounding tissue out of the acupuncture points do not show such kind of structure. It is the first time to reveal directly the specific structure of acupuncture points by X-ray imaging.

  10. Imaging study on acupuncture points

    Science.gov (United States)

    Yan, X. H.; Zhang, X. Y.; Liu, C. L.; Dang, R. S.; Ando, M.; Sugiyama, H.; Chen, H. S.; Ding, G. H.

    2009-09-01

    The topographic structures of acupuncture points were investigated by using the synchrotron radiation based Dark Field Image (DFI) method. Four following acupuncture points were studied: Sanyinjiao, Neiguan, Zusanli and Tianshu. We have found that at acupuncture point regions there exists the accumulation of micro-vessels. The images taken in the surrounding tissue out of the acupuncture points do not show such kind of structure. It is the first time to reveal directly the specific structure of acupuncture points by X-ray imaging.

  11. PowerPoint 2010 Bible

    CERN Document Server

    Wempen, Faithe

    2010-01-01

    Master PowerPoint and improve your presentation skills-with one book!. It's no longer enough to have slide after slide of text, bullets, and charts. It's not even enough to have good speaking skills if your PowerPoint slides bore your audience. Get the very most out of all that PowerPoint 2010 has to offer while also learning priceless tips and techniques for making good presentations in this new PowerPoint 2010 Bible. Well-known PowerPoint expert and author Faithe Wempen provides formatting tips; shows you how to work with drawings, tables, and SmartArt; introduces new collaboration tools; wa

  12. Oil-points - Designers means to evaluate sustainability of concepts

    DEFF Research Database (Denmark)

    Bey, Niki; Lenau, Torben Anker

    1998-01-01

    Designers have an essential influence on product design and are therefore one target group for environmental evaluation methods. This implies, that such evaluation methods have to meet designers requirements. Evaluation of sustainability of products is often done using formal Life Cycle Assessment....... This is investigated by means of three case studies where environmental impact is estimated using the EDIP method, the Eco-indicator 95 method, and the Oil Point method proposed by the authors. It is found that the results obtained using Oil Points are in acceptable conformity with the results obtained with more...

  13. Leverage points for improving global food security and the environment.

    Science.gov (United States)

    West, Paul C; Gerber, James S; Engstrom, Peder M; Mueller, Nathaniel D; Brauman, Kate A; Carlson, Kimberly M; Cassidy, Emily S; Johnston, Matt; MacDonald, Graham K; Ray, Deepak K; Siebert, Stefan

    2014-07-18

    Achieving sustainable global food security is one of humanity's contemporary challenges. Here we present an analysis identifying key "global leverage points" that offer the best opportunities to improve both global food security and environmental sustainability. We find that a relatively small set of places and actions could provide enough new calories to meet the basic needs for more than 3 billion people, address many environmental impacts with global consequences, and focus food waste reduction on the commodities with the greatest impact on food security. These leverage points in the global food system can help guide how nongovernmental organizations, foundations, governments, citizens' groups, and businesses prioritize actions.

  14. Oil-points - Designers means to evaluate sustainability of concepts

    DEFF Research Database (Denmark)

    Bey, Niki; Lenau, Torben Anker

    1998-01-01

    Designers have an essential influence on product design and are therefore one target group for environmental evaluation methods. This implies, that such evaluation methods have to meet designers requirements. Evaluation of sustainability of products is often done using formal Life Cycle Assessment....... This is investigated by means of three case studies where environmental impact is estimated using the EDIP method, the Eco-indicator 95 method, and the Oil Point method proposed by the authors. It is found that the results obtained using Oil Points are in acceptable conformity with the results obtained with more...

  15. Investing in Change. An Appraisal of Staff Development Needs for the Delivery of Modernised Occupational Training.

    Science.gov (United States)

    Further Education Unit, London (England).

    Regional and national seminars provided an opportunity for some 500 experts from industry and further education (FE) to analyze staff development needs related to modernization of occupational training in England. Eight issues affecting staff development were identified: environmental factors, access, relevance, design, delivery, assessment,…

  16. Myomectomy at time of cesarean delivery: a retrospective cohort study

    Directory of Open Access Journals (Sweden)

    Tabsh Khalil MA

    2004-07-01

    Full Text Available Abstract Background Myomectomy at time of cesarean delivery is traditionally discouraged because of the risk of hemorrhage. A retrospective cohort study was performed to determine whether myomectomy at time of cesarean delivery leads to an increased incidence of intrapartum and short-term postpartum complications. Methods A computer search of medical records from May 1991 to April 2001 identified a total of 111 women who underwent myomectomy at time of cesarean delivery and 257 women with documented fibroids during the index pregnancy who underwent cesarean delivery alone. Charts were reviewed for the following outcome variables: change in hematocrit from preoperative to postoperative period, length of operation, length of postpartum stay, incidence of postpartum fever, and incidence of hemorrhage. Hemorrhage was defined as a change in hematocrit of 10 points or the need for intraoperative blood transfusion. Results The incidence of hemorrhage in the study group was 12.6% as compared with 12.8% in the control group (p = 0.95. There was also no statistically significant increase in the incidence of postpartum fever, operating time, and length of postpartum stay. No patient in either group required hysterectomy or embolization. Size of fibroid did not appear to affect the incidence of hemorrhage. After stratifying the procedures by type of fibroid removed, intramural myomectomy was found to be associated with a 21.2% incidence of hemorrhage compared with 12.8% in the control group, but this difference was not statistically significant (p = 0.08. This study had 80% power to detect a two-fold increase in the overall incidence of hemorrhage. Conclusion In selected patients, myomectomy during cesarean delivery does not appear to result in an increased risk of intrapartum or short-term postpartum morbidity.

  17. Redesigning ambulatory care business processes supporting clinical care delivery.

    Science.gov (United States)

    Patterson, C; Sinkewich, M; Short, J; Callas, E

    1997-04-01

    The first step in redesigning the health care delivery process for ambulatory care begins with the patient and the business processes that support the patient. Patient-related business processes include patient access, service documentation, billing, follow-up, collection, and payment. Access is the portal to the clinical delivery and care management process. Service documentation, charge capture, and payment and collection are supporting processes to care delivery. Realigned provider networks now demand realigned patient business services to provide their members/customers/patients with improved service delivery at less cost. Purchaser mandates for cost containment, health maintenance, and enhanced quality of care have created an environment where every aspect of the delivery system, especially ambulatory care, is being judged. Business processes supporting the outpatient are therefore being reexamined for better efficiency and customer satisfaction. Many health care systems have made major investments in their ambulatory care environment, but have pursued traditional supporting business practices--such as multiple access points, lack of integrated patient appointment scheduling and registration, and multiple patient bills. These are areas that are appropriate for redesign efforts--all with the customer's needs and convenience in mind. Similarly, setting unrealistic expectations, underestimating the effort required, and ignoring the human elements of a patient-focused business service redesign effort can sabotage the very sound reasons for executing such an endeavor. Pitfalls can be avoided if a structured methodology, coupled with a change management process, are employed. Deloitte & Touche Consulting Group has been involved in several major efforts, all with ambulatory care settings to assist with the redesign of their business practices to consider the patient as the driver, instead of the institution providing the care.

  18. Subcutaneous concentrations following topical iontophoretic delivery of diclofenac.

    Science.gov (United States)

    Kasha, P C; Anderson, C R; Morris, R L; Sembrowich, W L; Chaturvedula, A; Banga, A K

    2012-10-01

    A self-contained Wearable Electronic Disposable Drug Delivery (WEDD(®)) patch was used to demonstrate that diclofenac levels delivered by iontophoresis are greater than estimated minimal effective concentrations in local subcutaneous tissue and are also greater than either passive transdermal or intravenous delivery using hairless rats. In vitro iontophoretic delivery was evaluated to optimize donor cell formulation using Franz diffusion cells and 1000 NMWL Millipore ultrafiltration membrane. In vivo animal studies were done using patches powered with a 4-volt system, consisting of a 1-volt Zn anode and Ag/AgCl cathode with built in 3-volt lithium battery. Blood and microdialysis samples were collected at different time points after patch application. Current levels increased to 1.0 mA at 30 min, then fell to a steady state of ~ 0.4 mA. Both WEDD(®) and passive patches produced measurable levels of diclofenac in the subcutaneous tissue below the application site (C(max) ± SE = 113.3 ± 61.7 ng/mL and 36.3 ± 15.9 ng/mL, respectively). The dose delivered in six hours was calculated to be 0.226 ± 0.072 mg and 0.430 ± 0.048 mg in passive and iontophoretic delivery, respectively. Diclofenac was not detected in the subcutaneous tissue after intravenous administration of 1.5 mg/kg diclofenac solution. The trend indicates that WEDD(®) can be used to successfully deliver diclofenac to subcutaneous tissue to concentrations higher when compared to either passive delivery or intravenous dosing of 1.5 mg/kg.

  19. Feasibility of Tactical Air Delivery Resupply Using Gliders

    Science.gov (United States)

    2016-12-01

    TACTICAL AIR DELIVERY RESUPPLY USING GLIDERS by Chaz R. Henderson December 2016 Thesis Advisor: Oleg A. Yakimenko Second Reader: Fotis A...DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE FEASIBILITY OF TACTICAL AIR DELIVERY RESUPPLY USING GLIDERS 5. FUNDING NUMBERS 6. AUTHOR(S...TACAD, Tactical Air Delivery Supply Glider, aerial delivery, autonomous aerial delivery, precision aerial delivery, Joint Precision Aerial

  20. View Dependent Sequential Point Trees

    Institute of Scientific and Technical Information of China (English)

    Wen-Cheng Wang; Feng Wei; En-Hua Wu

    2006-01-01

    Sequential point trees provide the state-of-the-art technique for rendering point models, by re-arranging hierarchical points sequentially according to geometric errors running on GPU for fast rendering. This paper presents a view dependent method to augment sequential point trees by embedding the hierarchical tree structures in the sequential list of hierarchical points. By the method, two kinds of indices are constructed to facilitate the points rendering in an order mostly from near to far and from coarse to fine. As a result, invisible points can be culled view-dependently in high efficiency for hardware acceleration, and at the same time, the advantage of sequential point trees could be still fully taken. Therefore, the new method can run much faster than the conventional sequential point trees, and the acceleration can be highly promoted particularly when the objects possess complex occlusion relationship and viewed closely because invisible points would be in a high percentage of the points at finer levels.