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Sample records for del retinoblastoma implicaciones

  1. Implicaciones del endotelio en la insuficiencia cardiaca

    Directory of Open Access Journals (Sweden)

    Beatriz Wills Sanín

    2014-10-01

    Full Text Available El papel del endotelio en la insuficiencia cardíaca (IC ha sido el centro de intensa investigación, puesto que tiene importantes implicaciones sistémicas expresadas en su efecto vasomotor, hemostático e inflamatorio. Existen diferencias individuales en el patrón de la disfunción endotelial de acuerdo a la etiología y severidad de la IC. La disfunción endotelial tiene un importante valor pronóstico en la IC y, aunque aún necesitamos conocer más aspectos de relevancia clínica, es evidente que esta condición se relaciona con desenlaces negativos en estos pacientes. Estamos a la espera de nuevos agentes farmacéuticos dirigidos específicamente al endotelio vascular. En esta revisión, nuestro objetivo es ofrecer un análisis crítico y contemporáneo de la evidencia disponible sobre las consecuencias patológicas y pronóstico de las anomalías endoteliales que definen el inicio, la historia natural y, en última instancia, los desenlaces en la IC.

  2. Retinoblastoma

    International Nuclear Information System (INIS)

    Desjardins, L.; Doz, F.; Schlienger, P.; Validire, P.; Quintana, E.; Zucker, J.M.

    1996-01-01

    Early symptoms of retinoblastoma (leukocoria, strabismus) and the various steps of the diagnosis and differential diagnosis are reviewed. Retrolental fibroplasia, larva migrans, Coats disease, and above all uveitis are the main differential diagnoses. Pathologic features that allow the diagnosis and have a bearing on the prognosis are described. Genetic factors involved in the genesis of retinoblastoma are reviewed, including recent data provides by molecular biology studies of chromosome 13. Currently available treatments include enucleation, external beam radiation, iodine-125 disks, xenon photo-coagulation, cryo-application, chemotherapy, and carbo-platinum combined with diode laser hyperthermia. The indications of each of these methods in intra- and extra-ocular retinoblastomas are discussed, as well as results and complications. Emphasis is put on the high risk of a second cancer. 47 refs., 4 figs

  3. Retinoblastoma

    International Nuclear Information System (INIS)

    Schipper, J.

    1980-01-01

    Retinoblastoma is a rare, highly malignant tumour of the retina which predominantly affects young children. The growth originates from single or multiple foci in the retina of one or both eyes. The tumour may occur either sporadically or may be inherited. Retinoblastoma is extra-ordinary in its medical, genetic and therapeutic significance. The irradiation method which has been used for the conservative treatment of retinoblastoma at Utrecht since 1971 is described. Treatment is carried out on a 6 MeV or 8 MeV linear accelerator using a lateral D-shaped field of 26x32 mm 2 . This D-shaped field is especially contoured to irradiate the entire retina with sparing of the radiosensitive lens as much as possible. Between 1971 and 1980, 30 children with retinoblastoma have received irradiation to at least one eye using the accurate irradiation technique. The results of treatment of these patients are presented. In the treatment it is not always possible to entirely exclude the lens from the treatment field. As a consequence, cataract may be induced. (Auth.)

  4. Aspectos fisiológicos del catión cinc y sus implicaciones cardiovasculares

    OpenAIRE

    Díaz García, Carlos Manlio; Álvarez González, Julio L.

    2009-01-01

    Introducción La versatilidad del catión cinc en la fisiología de diversos tipos celulares ha conllevado a una creciente atención de la comunidad científica sobre sus roles funcionales y la regulación a la que se encuentran sus niveles. Objetivos Presentar una revisión bibliográfica sobre el tema, con énfasis en las implicaciones cardiovasculares de este catión. Fuente de Datos El buscador Pubmed del Servicio Central de Información Biotecnológica de los Institutos Nacionales para la Ciencia, c...

  5. IMPLICACIONES SANITARIAS DEL ESTABLECIMIENTOY EXPANSION EN ESPAÑA DEL MOSQUITO AEDES ALBOPICTUS

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    Rubén Bueno Marí

    2012-01-01

    Full Text Available La expansión de Aedes albopictus por el Levante español no ha cesado desde su primigenia detección en nuestro país en el año 2004, habiéndose constatado ya su presencia en las provincias de Girona, Barcelona, Tarragona, Castellón, Alicante y Murcia. La elevada sinantropía de la especie, unida al alto grado de antropofília y extensa capacidad vectorial para transmitir diversas arbovirosis, han propiciado el retorno al sur de Europa de ciclos de transmisión activa de enfermedades frecuentes en el pasado como el Dengue o la aparición de virosis tropicales inéditas hasta entonces como Chikungunya. El presente manuscrito analiza de forma pormenorizada las implicaciones para la salud pública de la previsible expansión de Ae. albopictus por gran parte del territorio peninsular, en el contexto climático y sociodemográfico actual. Adicionalmente, también se discuten diversas cuestiones relativas al control poblacional de la especie en ambientes urbanos y periurbanos, así como los datos preliminares existentes acerca de otros aedinos invasores de reciente hallazgo en el continente europeo.

  6. Estilo de pensamiento del alumnado y profesorado universitario. Implicaciones educativas

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    Pedro ALLUEVA TORRES

    2010-01-01

    Full Text Available En el estudio se tomaron datos del alumnado de 1º curso, egresado y profesorado de 1º curso de la Universidad de Zaragoza en el curso 2008-2009, con el fin de analizar los diferentes perfiles de estilos de pensamiento predominantes para poder determinar qué metodologías y sistemas de evaluación en el proceso de enseñanza- aprendizaje pueden favorecer el aprendizaje y desarrollo de habilidades y aptitudes del pensamiento en el alumnado. Al realizar el análisis de los datos por grupos, áreas de conocimiento y sexo, se aprecian diferencias significativas en los perfiles de los estilos de pensamiento de los participantes.

  7. Algunas implicaciones jurídicas del matrimonio entre personas del mismo sexo en la Ciudad de México

    OpenAIRE

    Rojas Martínez, Alejandro

    2011-01-01

    El artículo analiza y expone el reconocimiento del matrimonio entre personas del mismo sexo en la Ciudad de México, así como sus implicaciones primarias a partir de su concreción en el sistema jurídico mexicano. El estudio contiene el análisis de la "Sociedad de Convivencia" como un mecanismo de reconocimiento de derechos de carácter civil a personas con relaciones personales de convivencia permanente, entre las que se encuentran las personas con identidad de género distinta de la correspondi...

  8. IMPLICACIONES DEL USO DE BUSCADORES EN EL COMPORTAMIENTO DE COMPRA ONLINE

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    Ruiz Mafé, C.

    2009-01-01

    Full Text Available El objetivo del presente trabajo es analizar los factores que influyen en el uso de buscadores y su incidencia en el comportamiento de compra en Internet. El análisis de resultados obtenidos a partir de una muestra representativa de 485 compradores por Internet españoles, pone de manifiesto que los consumidores que consideran la comodidad, reducciones de precio y amplitud de surtido como motivaciones relevantes para realizar compras online presentan una mayor predisposición al uso de buscadores en la realización de sus compras virtuales. La experiencia como internauta y como comprador en Internet son factores que influyen negativamente en el uso de buscadores para la realización de compras virtuales. En cuanto a las implicaciones, los resultados no muestran una influencia significativa del uso de buscadores en el volumen de gasto en Internet.

  9. Condicionantes e implicaciones

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    Humberto González Galbán

    2005-01-01

    tiene como objetivo mostrar la problemática del embarazo adolescente en términos sociodemográficos relacionados con su diferente grado de manifestación, condicionantes e implicaciones sociales en el contexto cubano.

  10. Algunas implicaciones jurídicas del matrimonio entre personas del mismo sexo en la Ciudad de México

    Directory of Open Access Journals (Sweden)

    Alejandro Rosas Martínez

    2011-07-01

    Full Text Available El artículo analiza y expone el reconocimiento del matrimonio entre personas del mismo sexo en la Ciudad de México, así como sus implicaciones primarias a partir de su concreción en el sistema jurídico mexicano. El estudio contiene el análisis de la “Sociedad de Convivencia” como un mecanismo de reconocimiento de derechos de carácter civil a personas con relaciones personales de convivencia permanente, entre las que se encuentran las personas con identidad de género distinta de la correspondiente a su sexo y las personas con preferencia sexual distinta de la heterosexual. También se estudia la reforma por la que el matrimonio entre personas del mismo sexo es posible y el criterio que la Suprema Corte de Justicia de México emitió sobre aquélla con base en una acción de inconstitucionalidad en la que se planteó el alcance del principio de igualdad en el constitucionalismo mexicano a partir de los conceptos de familia, matrimonio, heterosexualidad, homosexualidad, adopción e interés superior del menor.

  11. Creando subjetividades laborales: implicaciones del discurso psicológico en el mundo del trabajo y las organizaciones

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    Verónica Andrade

    2013-01-01

    Full Text Available El presente documento tiene como propósito explorar aportes de la psicología crítica al entendimiento de las dinámicas que se mueven en el mundo del trabajo y las organizaciones, y algunas críticas que esta aporta a la psicología organizacional y del trabajo moderna. Para tal fin, se plantean algunos elementos conceptuales de base para clarificar la acepción al respecto del concepto subjetividad y las implicaciones de la psicología crítica; igualmente se exponen algunas reflexiones que explicitan las formas en que el discurso psicológico -reflejado además en prácticas- está embebido en el mundo del trabajo y las organizaciones, y que en gran medida contribuye a construir las subjetividades de personas que trabajan, y las relaciones que se establecen al interior de las organizaciones de trabajo.

  12. Implicaciones para el Ecuador del Tratado de Libre Comercio con Estados Unidos en relación a los medicamentos y a la salud.

    OpenAIRE

    Logroño Barrionuevo, Milton Efraín

    2006-01-01

    1. LEGISLACION DE PROPIEDAD INTELECTUAL 2.EL TRATADO DE LIBRE COMERCIO: MEDICAMENTOS Y SALUD 3. IMPACTO DEL TRATADO DE LIBRE COMERCIO EN MEDICINAS Y SALUD.4. IMPLICACIONES SOCIALES DEL TRATADO DE LIBRE COMERCIO EN MEDICAMENTOS Y SALUD 5. PROPUESTA DE NEGOCIACIÓN EQUITATIVA DEL ECUADOR EN EL TRATADO DE LIBRE COMERCIO EN MEDICAMENTOS Y SALUD.6. CONCLUSIONES Y RECOMENDACIONES

  13. Neonatal retinoblastoma

    Directory of Open Access Journals (Sweden)

    Tero T Kivelä

    2017-01-01

    Full Text Available From 7% to 10% of all retinoblastomas and from 44% to 71% of familial retinoblastomas in developed countries are diagnosed in the neonatal period, usually through pre- or post-natal screening prompted by a positive family history and sometimes serendipitously during screening for retinopathy of prematurity or other reasons. In developing countries, neonatal diagnosis of retinoblastoma has been less common. Neonatal retinoblastoma generally develops from a germline mutation of RB1, the retinoblastoma gene, even when the family history is negative and is thus usually hereditary. At least one-half of infants with neonatal retinoblastoma have unilateral tumors when the diagnosis is made, typically the International Intraocular Retinoblastoma Classification (Murphree Group B or higher, but most germline mutation carriers will progress to bilateral involvement, typically Group A in the fellow eye. Neonatal leukokoria usually leads to the diagnosis in children without a family history of retinoblastoma, and a Group C tumor or higher is typical in the more advanced involved eye. Almost all infants with neonatal retinoblastoma have at least one eye with a tumor in proximity to the foveola, but the macula of the fellow eye is frequently spared. Consequently, loss of reading vision from both eyes is exceptional. A primary ectopic intracranial neuroblastic tumor known as trilateral retinoblastoma is no more common after neonatal than other retinoblastoma. For many reasons, neonatal retinoblastoma may be a challenge to eradicate, and the early age at diagnosis and relatively small tumors do not guarantee the preservation of both eyes of every involved child. Oncology nurses can be instrumental in contributing to better outcomes by ensuring that hereditary retinoblastoma survivors receive genetic counseling, by referring families of survivors to early screening programs when they are planning for a baby, and by providing psychological and practical support

  14. IMPLICACIONES TERRITORIALES DE UNA GRAN OBRA HIDRÁULICA: EL EMBALSE DEL TRANCO (CABECERA DEL GUADALQUIVIR

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    Eduardo Araque Jiménez

    2012-01-01

    Full Text Available Situado en la cabecera del Guadalquivir, el embalse del Tranco fue durante muchos años el de mayor capacidad de almacenamiento de agua de toda Andalucía. Sus aportaciones resultaron fundamentales para el sostenimiento del regadío en el gran valle bético, al tiempo que con sus aguas pudo generarse una parte de la energía eléctrica que se precisaba para la modernización del aparato productivo andaluz y la mejora de las condiciones de vida en multitud de hogares en el valle del Guadalquivir. Frente a estas perspectivas tan halagüeñas, las aguas embalsadas en el Tranco apenas tuvieron repercusiones socioeconómicas positivas para la Sierra de Segura. Las expropiaciones masivas a las que dio origen tanto la construcción del embalse como la repoblación forestal que lo acompañó, propiciaron la emigración masiva de centenares de vecinos, muchas veces en condiciones de extrema precariedad. Por otro lado, las aguas del Tranco nunca se utilizaron para la expansión del regadío por algunos de los fértiles valles próximos al embalse, ni la electricidad generada a pie de presa llegó a los hogares serranos, que siguieron careciendo de este servicio durante muchos años.

  15. Implicaciones sociales de la ciencia y la tecnología movilizadas en investigaciones STSPs. La visión del alumnado y del profesorado

    OpenAIRE

    Lupión Cobos, Teresa; Franco-Mariscal, Antonio Joaquín

    2017-01-01

    Se muestran los resultados de un estudio con profesores y estudiantes de secundaria que participaron en investigaciones que implican un modelo colaborativo estudiante-profesor-científico (STPSs) en el marco Science IES, referido a las implicaciones sociales de la ciencia y la tecnología movilizadas por estas investigaciones. Como instrumento se usaron varias cuestiones del cuestionario TOSRA sobre actitudes hacia la ciencia. Los resultados evidencian avances importantes en el cambio de actitu...

  16. Estudio del significado de las malformaciones congénitas y sus implicaciones en los programas de salud

    OpenAIRE

    Struck, Adelaida; Struck Vidal -Aguilera, Mony  de Lourdes; Chávez, Yohanna; Fernández, Francisco J

    2008-01-01

    En el siguiente artículo se realiza un estudio acerca del significado de las malformaciones congénitas y sus implicaciones en los programas de prevención para la población venezolana. Se hace uso de metodologías cualitativas y cuantitativas, utilizando como técnica para la recolección de los datos, el cuestionario. Su aplicación se lleva a cabo en dos centros maternos, Maternidad Concepción Palacios y Centro Materno Leopoldo Aguerrevere en Caracas-Venezuela. Se analizan como variables: el con...

  17. Implicaciones del marco teórico de lo imaginario en la Psicología Social

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    Teresa Aracena Vicente

    2015-03-01

    Full Text Available En el presente estudio abordaremos dos de las principales concepciones sobre los mecanismos implicados en la construcción significativa del mundo. Hablamos de la Teoría de las Representaciones Sociales (TRS, formulada desde la psicología, y del marco teórico de lo imaginario, formulado principalmente desde la antropología y la filosofía. Procederemos exponiendo, primero, la TRS y, posteriormente, los acercamientos al marco teórico de lo imaginario desde diferentes disciplinas, para señalar las aportaciones que ofrece este último a la psicología social, aportaciones éstas que complementan las de la TRS. Así, este estudio tiene como objetivos realizar un análisis teórico de la TRS y del marco teórico de lo imaginario y especificar las contribuciones e implicaciones del marco teórico de lo imaginario a la psicología social (y, más concretamente, a la psicología cultural de modo a observar cómo el concepto de imaginario social incluye y trasciende al de representación social(RS. Consideraremos las implicaciones ontológicas, epistemológicas, metodológicas y para la salud de la utilización del marco teórico de lo imaginario en la psicología cultural. En este sentido, propondremos la adopción de dicho concepto por la psicología, considerando que el mismo es fundamental por su capacidad explicativa, comprensiva, interpretativa y crítica.

  18. Las implicaciones del imaginario dominante “Barrios del Sur” en la producción del espacio urbano

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    Roberto Villalobos Vega

    2016-07-01

    Full Text Available La ciudad y lo que se entiende como su realidad, es una dinámica de producción territorial compleja e infinita que se teje recíprocamente entre su dimensión imaginaria (memoria, ideas, sentidos, emociones, etc., su dimensión empírica (edificaciones, infraestructura, acontecimientos, y la manera en que sus ciudadanos, tanto la sociedad civil como quienes ostentan el poder, amalgaman las distintas variables que la componen para simbolizarla y construirla constantemente (dimensión social. Ante esta premisa, el presente artículo esboza, como problemática urbana, la construcción mediática del territorio, desde el fenómeno de las representaciones de los “Barrios del Sur”, un imaginario dominante que se designa bajo generalizaciones negativas del territorio sur del casco central de la ciudad de San José, Costa Rica (Distrito Hospital y Catedral; y su profundo impacto en la producción de la ciudad a nivel de organización territorial (ubicación de miedos y culpas en la urbe, planificación, diseño e inversión urbana, y vivencia socio-espacial del entorno designado.

  19. Implicaciones del estudio de inestabilidad del ciclo celular en la biología del cáncer.

    OpenAIRE

    Luis Tume-Farfán

    2014-01-01

    Todas las células poseen mecanismos para mantener la integridad genómica que es vital para la supervivencia celular y la proliferación. Las células se dividen a tasas normale s durante su tiempo de vida, cuando esta tasa sobrepasa los límites normales ocurren alteraciones a nivel genético que afectan el control del ciclo celular por lo tanto estas células crecen y se dividen sin control y ya no responden a señalización extrace lular que indica la detención del ciclo y la apoptosis, estos meca...

  20. Las implicaciones de la convergencia económica en la industria del periodismo: el caso de Grupo Imagen

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    María Elena de Jesús Meneses Rocha

    2010-01-01

    Full Text Available El objetivo de este artículo es dar cuenta y analizar las transformaciones que ocurren a causa de la convergencia económica y corporativa en la industria periodística, así como sus implicaciones en la cultura profesional de los hasta ahora agentes validados socialmente para informar, es decir, los periodistas; también se analizan las consecuencias en la calidad de la información que reciben los ciudadanos de un país en proceso de consolidación democrática como es el caso de México proveniente los medios que han adoptado reingenierías convergentes, basadas en la digitalización de la base material de la producción noticiosa. Para ello, se toma como caso de estudio el Grupo Imagen, el primero en México en haber adoptado una reingeniería convergente, que a finales de la primera década del siglo parece ser una tendencia mundial en la industria del periodismo.

  1. IVF and retinoblastoma revisited

    NARCIS (Netherlands)

    Dommering, Charlotte J.; van der Hout, Annemarie H.; Meijers-Heijboer, Hanne; Marees, Tamara; Moll, Annette C.

    2012-01-01

    Objective: To evaluate the suggested association between IVF, retinoblastoma, and tumor methylation characteristics. Design: Laboratory analysis. Setting: National Retinoblastoma Center in the Netherlands. Patient(s): Retinoblastoma tumors from seven children conceived by IVF or intracytoplasmic

  2. IVF and retinoblastoma revisited

    NARCIS (Netherlands)

    Dommering, Charlotte J.; van der Hout, Annemarie H.; Meijers-Heijboer, Hanne; Marees, Tamara; Moll, Annette C.

    Objective: To evaluate the suggested association between IVF, retinoblastoma, and tumor methylation characteristics. Design: Laboratory analysis. Setting: National Retinoblastoma Center in the Netherlands. Patient(s): Retinoblastoma tumors from seven children conceived by IVF or intracytoplasmic

  3. Síndrome del cuidador de adultos mayores discapacitados y sus implicaciones psicosociales

    OpenAIRE

    Eliana Dueñas; María Anggeline Martínez; Benjamín Morales; Claudia Muñoz; Ana Sofía Viáfara; Julián A. Herrera

    2006-01-01

    Objetivo: Describir la prevalencia del síndrome del cuidador y las características psicosociales de los cuidadores de adultos mayores discapacitados. Materiales y métodos: Se realizó un estudio piloto de casos y controles en el Valle del Cauca durante el 2003-2004 para evaluar la funcionalidad familiar (APGAR familiar), la ansiedad y depresión (escala de Goldberg), la presencia de enfermedades (cuidadores y no cuidadores), y la prevalencia del síndrome del cuidador (escala de Zarit). Resul...

  4. Síndrome del cuidador de adultos mayores discapacitados y sus implicaciones psicosociales

    OpenAIRE

    Dueñas, Eliana; Martínez, María Anggeline; Morales, Benjamín; Muñoz, Claudia; Viáfara, Ana Sofía; Herrera, Julián A

    2006-01-01

    Objetivo: Describir la prevalencia del síndrome del cuidador y las características psicosociales de los cuidadores de adultos mayores discapacitados. Materiales y métodos: Se realizó un estudio piloto de casos y controles en el Valle del Cauca durante el 2003-2004 para evaluar la funcionalidad familiar (APGAR familiar), la ansiedad y depresión (escala de Goldberg), la presencia de enfermedades (cuidadores y no cuidadores), y la prevalencia del síndrome del cuidador (escala de Zarit). Resultad...

  5. Estudio anatómico de la rama superficial del nervio radial, implicaciones quirúrgicas

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    Enrique Vergara Amador

    2010-07-01

    Full Text Available Antecedentes. Conocer la anatomía de la rama superficial del nervio radial, es indispensable para la adecuada práctica de cirugías que involucran la mano y la muñeca. Objetivo. Determinar las relaciones del nervio radial y sus ramas con el tubérculo de Lister, la apófisis estiloides del radio y la distribución en el dorso de la mano. Material y métodos. Se disecaron 25 piezas de cadáveres frescos. Se identificó la rama superficial del nervio radial y se midió la distancia entre la salida del nervio y la apófisis estiloides del radio. Se identificaron las ramas del nervio en el antebrazo distal y en la muñeca y se midieron respecto a la apófisis estiloides y al tubérculo de Lister. Resultados. La rama superficial del nervio radial emergió en la región dorsal y radial del tercio distal del antebrazo entre el músculo braquiradialis y el extensor carpis radialis longus, a una distancia de 8,45 cm proximal a la apófisis estiloides. Su primera rama de división discurrió palmar a la apófisis estiloides radial a una distancia promedio de 0,74 cm respecto a la misma. El tronco principal se dividió en varias ramas terminales así: proximal a la apófisis estiloides del radio (28%, a nivel de la misma (12% y distal (60%. El patrón de distribución de las ramas nerviosas en la base de los dedos más frecuente fue el del primero, segundo y el lado radial del tercer dedo (56%. Discusión. Este estudio mostró la gran variabilidad de la rama superficial del nervio radial en el dorso de la mano y la alta probabilidad de daño del mismo durante los procedimientos abiertos, artroscópicos o procedimientos percutáneos en la muñeca.

  6. Implicaciones del protocolo de Madrid en el derecho marcario de la comunidad andina de naciones

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    Edwin Jesith Bernal Ramírez

    2013-11-01

    Full Text Available El Protocolo de Madrid de 27 de junio de 1989 es una herramienta útil para el registro internacional de marcas, pues es evidente que los países miembros del Protocolo tienen ventajas comparativas respecto a los otros que no son parte, esto en relación con el mejoramiento de la protección internacional de sus marcas. El artículo académico muestra de manera somera el procedimiento, las ventajas y desventajas del Protocolo de Madrid y su respectivo impacto en la Comunidad Andina de Naciones.

  7. Implicaciones en el crecimiento y desarrollo cráneo-facial por ausencia del hueso hioides

    OpenAIRE

    TORRE M., HILDA; MENCHACA F., PEDRO N.; FLORES LEAL, VIELMINA; MERCADO HERNÁNDEZ, ROBERTO

    2004-01-01

    Se realizó un estudio prospectivo, experimental, en ratas Sprague-Dawley, observando el crecimiento y desarrollo cráneo-facial ante la ausencia del hueso hioides. Los resultados mostraron: apertura oral, posterorrotación mandibular, aumento en la longitud de los procesos alveolares, así como una tendencia al aumento en el crecimiento mandibular.

  8. IMAGINARIOS DEL MIEDO EN EL CONTEXTO URBANO DE MANIZALES: IMPLICACIONES MEDIOAMBIENTALES

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    Valencia M. Victoria Eugenia

    2008-07-01

    Full Text Available El artículo es el resultado de un estudio adelantado en la Universidad Nacional de Colombia, Sede Manizales, en la Maestría en Medio Ambiente y Desarrollo (Área de Estudios Urbanos. Buscó presentar de una manera compleja, rizomática y en red, las relaciones que en el contexto urbano, se establecen entre habitante y ciudad desde la emoción del miedo, y las posibles conexiones que desde lo simbólico, puedan darse frente a situaciones ambientales concretas. Los principales objetivos del estudio se orientaron a identificar los imaginarios del miedo provenientes de la vivencia urbana de algunos habitantes de la ciudad de Manizales, categorizar las principales temáticas y personajes generadores de miedo en el contexto urbano y conocer desde los relatos, las subjetividades y los niveles de conciencia frente al contexto medioambiental en el que se está inmerso. Gracias a elementos aportados desde la teoría psicoanalítica, se logró el diseño de una metodología cualitativa novedosa, basada en relatos que se apoyaron en fotografías de la ciudad. Algunas de las conclusiones del estudio, apuntaron a señalar una gran sensibilidad de los participantes hacia la problemática ambiental. Los temas de los relatos plantearon situaciones en las que las personas se sintieron vulnerables y en riesgo. Así mismo, en los contenidos de los relatos, los sistemas social y natural aparecieron como instancias complejas de mutua afectación. Al tiempo, se detectó en los contenidos de las historias, una necesidad personal de compromiso para el cambio de las realidades ambientales que se están viviendo.

  9. Comportamiento organizacional positivo: las implicaciones del engagement en el entorno laboral

    OpenAIRE

    Mercedes Almeida Quezada; Isidro Fierro Ulloa

    2015-01-01

    El presente estudio aborda el concepto de Comportamiento Organizacional Positivo como herramienta para potencializar las habilidades de los colaboradores dentro de una organización. Desde una perspectiva teórica, tiene como Objetivo analizar el constructo del engagement como elemento generador de compromiso y buen ambiente laboral. Profundizando en el documento, se describen las aristas que, llevadas a la práctica, permitirán una correcta ejecución de este modelo, repercutiendo de esta forma ...

  10. Aspectos moleculares del virus de la parvovirosis canina y sus implicaciones en la enfermedad

    Directory of Open Access Journals (Sweden)

    César A. Díaz R.

    2008-06-01

    Full Text Available El parvovirus canino tipo 2 (CPV-2 es el agente causal de una enfermedad infecto-contagiosa que produce una gastroenteritis aguda hemorrágica que afecta a caninos jóvenes. El CPV-2 se adaptó a la especie canina por mutación del virus de la Panleucopenia felina (FPV luego de su paso por animales silvestres como el hurón y los zorros. La alta variabilidad de la proteína viral 2 (VP2 es la causa principal del amplio rango de hospedadores y de las reacciones cruzadas entre las variantes. En la actualidad, la secuenciación de esta proteína ha permitido identificar tres variantes del virus conocidas como 2a, 2b y 2c que conviven en el mundo con diferencias en tropismo celular, infecciocidad y patogenicidad. El virus ssADN ha presentado una gran variación génica en cortos períodos de tiempo lo que indica un alto grado de selección por evolución sólo comparable con virus RN, esta alta variabilidad no se ha aclarado totalmente. El empleo de las técnicas moleculares permitirá diferenciar entre cepas vacunales y de campo, tanto como contar con técnicas diagnósticas confiables y específicas.

  11. Implicaciones del comercio por el puerto de San Blas durante la guerra de independencia

    Directory of Open Access Journals (Sweden)

    Trejo Barajas, Dení

    2006-12-01

    Full Text Available This article analyzes the importance acquired during the Independence war by the maritime trade coming from other Central and South American ports and operating through the San Blas port. The antecedents of the colonial commerce are studied, as well as the British presence and the consequences of the free trade measures taken by the Spanish government which particularly affected the Nueva Galicia Intendencia and the Pacific coasts of Nueva España. In the end, this highly polemical traffic permitted by the Spanish authorities strengthened Nueva Galicia both politically and economically, and prefigured the regionalism that was to be characteristical in 19th Century Mexico.

    En este artículo se analiza la importancia que adquirió, durante la guerra de Independencia, el comercio marítimo por el puerto de San Blas procedente de Panamá y otros puertos centro y sudamericanos. Se exponen los antecedentes relativos a la crisis del comercio colonial, la presencia inglesa y los efectos de las medidas de libre comercio adoptadas por el gobierno español que afectaron de manera particular a la intendencia de Nueva Galicia y las costas del Pacífico novohispano. Se revisan las consecuencias de este polémico tráfico permitido por las autoridades hispanas y que desembocó en el fortalecimiento político y económico de la Nueva Galicia, prefigurando el regionalismo característico del siglo XIX mexicano.

  12. La predicción del rendimiento académico: Procedimientos, resultados e implicaciones

    OpenAIRE

    Tourón, J. (Javier)

    1985-01-01

    El estudio de los factores que influyen en el rendimiento académico es importante a la hora de conocer el grado en que los diversos elementos que actúan en el proceso educativo formal influyen en el aprendizaje de los alumnos. El conocimiento de esos factores hará posible mejorar la tarea educativa, aunque lo fundamental no es el mero conocimiento de estos factores, sino las accionas que puedan suscitar en los profesores, ya que modificar los elementos del proceso llevara a la modificac...

  13. La época del imperialismo y sus implicaciones en la salud pública

    OpenAIRE

    Estrada M, John H

    2008-01-01

    Este artículo estudia el denominado gran siglo XIX o largo siglo XIX, que comprende todo este siglo más las décadas que antecedieron y acompañaron a la primera guerra mundial y que se corresponde con la consolidación del imperialismo. Desde la perspectiva de la salud pública, es importante por haberse producido la transición de la higiene a la salud pública y que ya en 1880 caracteriza el advenimiento de la teoría bacteriológica y su influencia en las medidas de sanidad estatal imperantes. La...

  14. Algunas implicaciones y problemas bioéticos del diagnóstico prenatal

    Directory of Open Access Journals (Sweden)

    Fernando Fabó

    2008-08-01

    Full Text Available Este artículo define y presenta en la primera parte una panorámica general sobre las técnicas de diagnosis prenatal, justificando la licitud del recurso a las mismas en base a los avances de la medicina fetal. Viene fuertemente cuestionada la validez de la PDG y se aclaran algunos puntos relativos a la indicación médica. En la segunda parte se profundizan los aspectos bioéticos, explicando los principios éticos para una diagnosis prenatal plenamente respetuosa del pequeño paciente (valor ético positivo de la diagnosis; proporcionalidad terapéutica; consenso informado; responsabilidad-libertad. Se insiste en la objeción de conciencia y se presentan algunas sentencias que permiten evidenciar algunos problemas jurídico-legales relacionados con la diagnosis prenatal. Las conclusiones orientan a un nuevo enfoque de la prevención de las enfermedades genéticas y malformativas.

  15. Comportamiento organizacional positivo: las implicaciones del engagement en el entorno laboral

    Directory of Open Access Journals (Sweden)

    Mercedes Almeida Quezada

    2015-12-01

    Full Text Available El presente estudio aborda el concepto de Comportamiento Organizacional Positivo como herramienta para potencializar las habilidades de los colaboradores dentro de una organización. Desde una perspectiva teórica, tiene como Objetivo analizar el constructo del engagement como elemento generador de compromiso y buen ambiente laboral. Profundizando en el documento, se describen las aristas que, llevadas a la práctica, permitirán una correcta ejecución de este modelo, repercutiendo de esta forma en resultados anuales positivos y en el aumento de la productividad. Colaboradores engaged son sinónimos de un buen provenir empresarial; el éxito radicará en los índices de motivación de cada uno de los miembros que componen la organización.

  16. Polimorfismos del receptor adrenérgico b1 y sus implicaciones farmacodinámicas

    Directory of Open Access Journals (Sweden)

    Ignacio Rodríguez

    2000-02-01

    Full Text Available

    Introducción: Los betabloqueadores son uno de los grupos farmacológicos que cuentan con mayor efectividad clínica comprobada; se ha demostrado que disminuyen la mortalidad y morbilidad por enfermedad cerebrovascular, eventos coronarios y falla cardíaca. Todos estos medicamentos tienen como común denominador el antagonismo de los receptores adrenérgicos b1, los cuales, se encuentran ubicados principalmente en cardiomiocitos, células yuxtaglomerulares y adipocitos; donde producen, en respuesta al estimulo por catecolaminas, aumento de la contractilidad y frecuencia cardíacas, liberación de renina y lipólisis respectivamente. Recientemente se descubrieron dos polimorfismos en este receptor. El primero de ellos, una sustitución de A por G en el nucleótido 145, genera un cambio del aminoácido Serina por Glicina en la posición 49 (Gly49Ser. El segundo polimorfismo, una sustitución de G por C en el nucleótido 1165, produce un cambio del aminoácido Arginina por Glicina en la posición 389 (Arg389Gly ubicado en la cola citoplasmática del receptor, que es una de las regiones de interacción con la proteína G(1. Estudios in vitro con las dos variantes polimórficas Arg389Gly del receptor, han demostrado que los receptores con Arg389 Herramienta para la Deteccion de Retinoblastoma

    OpenAIRE

    Vargas-Cuentas , Natalia Indira; Roman-Gonzalez , Avid

    2015-01-01

    International audience; El retinoblastoma, es un tumor que se presenta en la retina de las personas, especialmente en los niños. Una detección temprana del mismo, podría ser muy útil y salvar la vida del niño. Es en ese sentido, que el presente trabajo propone una herramienta sencilla para la detección de retinoblastoma analizando fotografías tomadas con flash en las cuales, en el ojo del niño se puede detectar la presencia de leucoria. Esta detección se realiza utilizando las funciones de de...

  17. IMPLICACIONES Y COSTO-EFECTIVIDAD DEL ALTA TEMPRANA DEL BINOMIO MADRE-HIJO DESPUÉS DE UN PARTO NORMAL

    Directory of Open Access Journals (Sweden)

    Juan David Rueda

    2015-03-01

    Full Text Available Introducción: Se revisó la literatura internacional sobre alta temprana (24-48 horas y su relación con complicaciones, para elaborar un modelo de costo-efectividad en recién nacidos, por parto vaginal a término no complicado, comparándola con ultratemprana (&24 horas que incluya un programa de control posnatal organizado que permita evaluar a la madre y al bebe a las 48- 72 horas. Materiales y métodos: Se diseñó un árbol de decisión para un hospital que preste servicio de obstetricia, desde la perspectiva del sistema de salud colombiano. El horizonte de tiempo fue el periodo neonatal (primer mes de vida extrauterina. La efectividad fue medida en los siguientes desenlaces: reconsultas evitadas y hospitalizaciones evitadas. Resultados: Se estima que cada año nacen 336.000 niños por partos vaginales a término. Cada día de reducción de estancia hospitalaria implicaría 29 mil millones de pesos de ahorro para el sistema de salud colombiano. Comparada con el alta temprana ($88.015 el alta ultratemprana cuesta más ($93.129 y se asocia con una mayor tasa de hospitalización (55 incrementales por cada 1000 y de reconsultas (320 adicionales por cada 1000. Conclusión: Un alta ultratemprana se justificaría solo si se cumpliera con una detallada lista de chequeo para garantizar que el ahorro para el sistema no se traduzca en mayores complicaciones para la madre y el niño.

  18. FUNCIONES EJECUTIVAS EN NIÑOS Y ADOLESCENTES: IMPLICACIONES DEL TIPO DE MEDIDAS DE EVALUACIÓN EMPLEADAS PARA SU VALIDEZ EN CONTEXTOS CLÍNICOS Y EDUCATIVOS

    Directory of Open Access Journals (Sweden)

    Trinidad García Fernández

    2014-09-01

    Full Text Available Las funciones ejecutivas implican un amplio rango de habilidades relacionadas con la regulación del pensamiento, el comportamiento y el propio estado emocional. Teniendo en cuenta la variedad de componentes que forman este constructo, no es sorprendente que su evaluación plantee ciertas dificultades. En este sentido, pese a que numerosos estudios han mostrado la importancia de dichos componentes como determinantes del desempeño académico y social, así como su utilidad en el diagnóstico y la intervención en diversas problemáticas durante la infancia y la adolescencia, aspectos como la validez ecológica de las medidas tradicionalmente empleadas para su evaluación, imponen hoy ciertas limitaciones a la validez y generalización de los resultados obtenidos en este ámbito. El objetivo de este trabajo es analizar las características de las medidas de evaluación más ampliamente empleadas y su grado de aplicabilidad en contextos clínicos y educativos, de lo cual se desprenden una serie de implicaciones prácticas.

  19. LA HIPÓTESIS DEL TRAUMA EN EL ABUSO SEXUAL: REVISIÓN CRÍTICA E IMPLICACIONES

    Directory of Open Access Journals (Sweden)

    Agustín Malón Marco

    2008-07-01

    Full Text Available Se lleva a cabo una revisión crítica de la hipótesis traumática en el estudio de las experiencias eróticas tempranas con personas más mayores. Esta hipótesis, la más habitual en la literatura científica, consiste en dar por cierto que son en su mayoría experiencias graves y de serias consecuencias negativas a corto y/o largo plazo. Cuestionaremos su fundamentación empírica, para después pasar a las implicaciones científicas y profesionales surgidas de otra lectura de los datos disponibles. Para ello se analizan críticamente nueve revisiones previas sobre la cuestión, publicadas entre 1981 y 1998. Esta revisión de revisiones sugiere que estaría perfectamente sustentada la hipótesis de que en la gran mayoría de los casos no suelen producirse daños serios ni mucho menos permanentes en los implicados. El análisis invita a un replanteamiento teórico, epistemológico y tecnológico de la investigación y la intervención social.

  1. Implicaciones intelectuales y metodológicas en la selección de los autores y la terminología traductora castellana del siglo XV

    Directory of Open Access Journals (Sweden)

    Allés Torrent, Susanna

    2015-06-01

    Full Text Available Translations were a crucial channel for the reception of Italian Humanism in the Iberian Peninsula. This intellectual activity not only led to the recuperation of a significant part of the classical Greco-Roman legacy, but also fomented engagement with the works and ideas of contemporary Italian authors. On the one hand, this article underscores the critical role of translation in cultural transfers between both peninsulas and shows the change in authors selected to translate over the course of fifteenth century. On the other hand, it analyzes the implications of these author selections, arguing that they reveal at once an ideological transformation, a change in the conception of the very act of translation, and the adoption of new terminology.Las traducciones constituyeron uno de los canales prioritarios en la recepción del humanismo italiano en la Península Ibérica. A través de esta actividad intelectual, no sólo se recuperó una parte considerable del legado clásico grecolatino, sino que propició un acercamiento a la obra y a las ideas de los autores italianos contemporáneos. Por un lado, el presente trabajo insiste en el papel central de la traducción en el marco de la transferencia cultural entre ambas penínsulas y evidencia el cambio en la selección de los autores traducidos a lo largo del siglo XV; por otro lado, se analizan las implicaciones de dichas elecciones que, además de constituir una transformación a nivel ideológico, supusieron un cambio en la concepción de la actividad de la traducción y en la adopción de una nueva terminología.

  2. Current treatment of retinoblastoma

    International Nuclear Information System (INIS)

    Shields, J.A.

    1985-01-01

    Retinoblastoma is a highly malignant intraocular tumor of childhood which requires prompt treatment once the diagnosis has been established. The traditionally accepted methods include enucleation, external irradiation, scleral plaque irradiation, photocoagulation, cryotherapy, chemotherapy. This article will provide an update on the modern methods of treatment which are available for retinoblastoma. It is based largely on personal experience with approximately 200 new patients with retinoblastoma who were evaluated and treated between 1974 and 1984 in the Oncology Service of Wills Eye Hospital with an overall survival of 97%. This article will be an overall review which will not go into statistical detail. (Auth.)

  3. IMPLICACIONES JURÍDICAS DE LA EXPIRACIÓN DEL CONTRATO DE ARRENDAMIENTO DE VIVIENDA URBANA Y DE LOCAL COMERCIAL

    Directory of Open Access Journals (Sweden)

    Sergio Alfredo Martínez Ramírez

    2014-05-01

    Full Text Available El contrato de arrendamiento de vivienda ha tenido amplio desarrollo normativo, su regulación se encuentra contenida en la ley 820 de 2003. Por su parte el contrato de arrendamiento comercial se encuentra regulado exiguamente en los artículos 518 a 524 del Código de Comercio; paralelamente a estas normatividades está el Decreto 3817 de 1982, el cual en su artículo 5 regula la situación del arrendador en los casos en que el arrendatario ha dado cumplimiento a las obligaciones dinerarias derivadas del contrato, sosteniendo que en dichos casos, el vencimiento del término inicial no es causal para dar por terminado el contrato, norma que va en contravía de los dispuesto en el artículo 2008, numeral 2 del Código Civil, que estipula que la expiración del término pactado en el contrato es causal para darlo por terminado. Dicha norma se encuentra vigente y tiene plena aplicabilidad tanto en los contratos de arrendamiento de vivienda, como en contratos comerciales. En consecuencia se plantea que el numeral 5 del artículo 3817 de 1982, implica una limitación al derecho de dominio del propietario y va en contra vía del principio que establece que el contrato es Ley para las partes.

  4. Trabajo creativo y reestructuración productiva en la industria cultural de la publicidad farmacéutica online en el marco del capitalismo contemporáneo : implicaciones socioeconómicas en Argentina, 2008 - 2012

    OpenAIRE

    Ruiz, Silvina

    2013-01-01

    Esta Tesis se propone contribuir al conocimiento sobre la organización productiva y del trabajo que denominamos “Creativo / Original” vs. "Creativo / Comercial”, en la producción de contenidos informacionales en la Industria Cultural de la Publicidad Farmacéutica online en la Argentina, y sus implicaciones para el desarrollo de los/as trabajadores/as y del país. Con ese objetivo nuestra investigación -si bien se concentra en el nivel micro social en base a la experiencia de una empresa trasna...

  5. Computed tomography of retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Lindahl, S.

    Retinoblastoma is the most common primary malignant intraocular tumor in children. The clinical features are leucocoria and/or strabismus. The ophthalmic diagnosis is straight forward in clear eye media with a white gray mass in the fundus. With opaque ocular media, other diagnostic procedures such as CT and ultrasonography are important. In the present study the results of CT examinations of 23 patients with histologically proven retinoblastomas are presented. The mean age of the patients was two years. The characteristic CT finding is a partly calcified intravitreous mass lesion mostly confined within the eyeball. Two cases showed retrobulbar extension and two intracranical tumor extension. No metastasis was found in the brain, liver, spleen, long bones, chest or skull. The radiologic screening procedures for retinoblastoma metastasis are discussed. In patients suspected to have a retinoblastoma, it is recommended to perform CT of the orbits and brain in order to detect the tumor and its possible retrobulbar and intracranial extension.

  6. Computed tomography of retinoblastoma

    International Nuclear Information System (INIS)

    Lindahl, S.

    1986-01-01

    Retinoblastoma is the most common primary malignant intraocular tumor in children. The clinical features are leucocoria and/or strabismus. The ophthalmic diagnosis is straight forward in clear eye media with a white gray mass in the fundus. With opaque ocular media, other diagnostic procedures such as CT and ultrasonography are important. In the present study the results of CT examinations of 23 patients with histologically proven retinoblastomas are presented. The mean age of the patients was two years. The characteristic CT finding is a partly calcified intravitreous mass lesion mostly confined within the eyeball. Two cases showed retrobulbar extension and two intracranical tumor extension. No metastasis was found in the brain, liver, spleen, long bones, chest or skull. The radiologic screening procedures for retinoblastoma metastasis are discussed. In patients suspected to have a retinoblastoma, it is recommended to perform CT of the orbits and brain in order to detect the tumor and its possible retrobulbar and intracranial extension. (orig.)

  7. Drugs Approved for Retinoblastoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for retinoblastoma. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  8. Límites de consistencia y sus implicaciones agrícolas en un suelo ultisol de sabana del estado Monagas, Venezuela

    Directory of Open Access Journals (Sweden)

    Américo Hossne

    2004-01-01

    Full Text Available El conocimiento de las propiedades físicas de los suelos agrícolas y bióticos proporciona información para el manejo de equipos agrícolas, procesos de compactación y la labranza convencional y conservacionista. A medida que la humedad edáfica aumenta, genera diversos estados del suelo; e.g. una menor interacción entre partículas adyacentes y un comportamiento que se aproxima al del líquido. El inicio de la sensibilidad de compactación, parece ser el límite plástico del suelo bajo una bien definida energía de compactación. El objetivo general, de este estudio fue caracterizar sistemáticamente, con las implicaciones de ingeniería posibles, los suelos agrícolas de sabana del Estado Monagas de Venezuela. Los objetivos específicos consistieron en determinar: a- los límites de Atterberg; y b- el índice de plasticidad y friabilidad. Para ello se utilizó los procedimientos de laboratorio de Mecánica de Suelos: ASTM D427-61 para el límite de contracción, ASTM D424-59 para el límite plástico y ASTM 423-66 para el límite líquido, de un suelo de sabana en muestras aleatorias a las profundidades de 0-15, 15-30, 30-45 y 45-60 cm. Se utilizó el análisis de regresión para interpretar la proporción de la variancia entre parámetros. Los resultados indicaron valores de: límite de contracción de 4,22–5,20%, límite plástico de 12,92–14,04%, límite líquido de 16,94–19,43%, índice de plasticidad de 3,59–5,78% e índice de friabilidad de 8,63–8,84%. Se concluye que los valores concuerdan con la bibliografía y el rango de uso agrícola se encuentra entre 8% y 15% para el suelo en estudio.

  9. Programa nacional de prevención y consejería genética del retinoblastoma mediante detección de mutaciones en el gen rb.

    OpenAIRE

    Frayle, H.; Guevara, G.

    2011-01-01

    El retinoblastoma es un raro tumor ocular que se diagnostica en los niños, 40% de los casos se consideran hereditarios y 60% esporádicos. El modelo genético propuesto por Knudson involucra
    una la doble mutación inactivante del gen Rb, exclusivamente somática en los esporádicos y germinal más somática en los hereditarios. Esta investigacin tuvo como objetivo caracterizar las mutaciones en el gen Rb mediante secuenciación directa y evaluar su utilidad en la consejería genética....

  10. Complejidad ambiental en el Bajío mexicano: implicaciones del proyecto civilizatorio vinculado al crecimiento económico

    Directory of Open Access Journals (Sweden)

    Daniel Tagle Zamora

    2017-01-01

    Full Text Available El objetivo de este artículo es visibilizar las contradicciones ambientales de la lógica del crecimiento económico adoptada en el Bajío guanajuatense, en el marco de la economía ecológica, que muestra la inviabilidad socioambiental de las políticas públicas en Guanajuato. El índice del desarrollo humano municipal, la compilación de informes ambientales del estado, los talleres con actores clave, así como la retroalimentación con pares académicos, expertos en la temática ambiental, reflejan el contraste ambiental del modelo de desarrollo que impera y opera de manera normalizada en esta región. Es notoria la desarticulación deliberada entre las políticas económica y ambiental, que favorece a la primera gracias a la permisibilidad de la segunda, lo que se traduce en la trasferencia de los costos socioambientales del sector privado al público, y apoya la lógica de la acumulación frente al interés común. Esto a través de la contaminación y la sobreexplotación de los cuerpos de agua, la contaminación atmosférica, el extractivismo, la sobregeneración de residuos sólidos, la pérdida de calidad de los suelos que, entre otros, son algunos elementos que tensionan la capacidad de resiliencia social y ambiental de esta zona. Esta visibilización de la crisis ambiental refleja la pertinencia de incorporar un enfoque analítico capaz de abordar una crisis multidimensional, y comprender que ésta se encuentra en la parte ilógica de la lógica del crecimiento económico.

  11. Evaluación del riesgo y reincidencia en agresores sexuales sentenciados: implicaciones para las víctimas

    Directory of Open Access Journals (Sweden)

    Eva María Jiménez González

    2010-01-01

    Full Text Available El estudio de la ocurrencia de los delitos sexuales implica una visión tripartita en la que se involucran elementos que interactúan de manera constante y en ocasiones de manera desventajosa. Por un lado, se considera la reivindicación y reparación para con la víctima como receptora del daño; por otro, el tratamiento y la aplicación de justicia al victimario, y finalmente, los procesos de regulación e impartición del sistema penal en su intento por representar el mecanismo regulador que restablezca las repercusiones creadas a partir de la victimización. Debido, entonces, a la complejidad de los delitos, así como a la discusión acerca del equilibrio que requiere la reinserción para evitar la revictimización, en el presente documento se hace referencia a los perfiles empíricos descriptivos en muestras de población penitenciaria españolas y mexicanas, y su implicación en la reincidencia o riesgo victimal, enfatizando que el diagnóstico en el área criminológica es una herramienta fundamental que requiere de medios de evaluación específica, válida y confiable para tener aproximaciones reales acerca de la disposición de una persona a la hora de cometer conductas antisociales; relevante desde una perspectiva de política criminal, y con la finalidad del estudio psicológico del agresor, estudio que en última instancia apoyaría al tratamiento penitenciario y a la prevención del delito.

  12. Evolución del concepto de desarrollo e implicaciones en el ámbito territorial: experiencia desde Cuba

    Directory of Open Access Journals (Sweden)

    Francisco Ángel Becerra Lois

    2005-01-01

    su desarrollo integral. Se ofrecen pautas generales para argumentar con cientificidad y con base en las teorías del desarrollo cuáles son los componentes o factores que subyacen tras la dinámica de desarrollo socioeconómico a escala territorial "preferentemente en el ámbito de localidad", durante un tiempo razonable.

  13. Percepcion de los profesores universitarios acerca del concepto cultura cientifica y de sus implicaciones en el nuevo bachillerato del Recinto de Rio Piedras de la Universidad de Puerto Rico

    Science.gov (United States)

    Ramos Pastrana, Nilsa

    El Senado Academico del Recinto de Rio Piedras de la Universidad de Puerto Rico aprobo en el ano academico 2005-2006 la Certificacion 46, que contiene los lineamientos de un nuevo bachillerato. Este nuevo bachillerato introdujo cambios significativos en el curriculo tradicional. Entre ellos se encuentra la reduccion del componente de educacion general y el de Ciencias Biologicas en particular. La reduccion de creditos en el componente de Ciencias Biologicas ha obligado a reevaluar el concepto de cultura cientifica que desarrollan esos cursos. El proposito del estudio consistio en auscultar las percepciones de los profesores de las Facultades de Administracion de Empresas, Humanidades, Ciencias Sociales, Ciencias Naturales, Educacion y Estudios Generales del Recinto de Rio Piedras de la Universidad de Puerto Rico en torno al concepto de cultura cientifica, los contenidos disciplinares del curso de Ciencias Biologicas y la reduccion de creditos en el nuevo bachillerato. Las preguntas que guiaron la investigacion fueron: ¿cuales son las percepciones que tienen los profesores de las Facultades de Administracion de Empresas, Ciencias Sociales, Estudios Generales, Ciencias Naturales, Humanidades y Educacion, en torno al concepto de cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿cuales son las percepciones que tienen los profesores de Ciencias Biologicas en torno al concepto cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿existen diferencias significativas por facultad, genero, experiencia, rango y nombramiento en las percepciones que tienen los profesores del Recinto de Rio Piedras de la Universidad de Puerto Rico sobre los elementos que caracterizan la cultura cientifica y los contenidos biologicos que deben tener los egresados del Recinto? ¿que implicaciones curriculares tienen estos testimonios en el desarrollo del concepto de cultura cientifica en el nuevo bachillerato? Para realizar la

  14. L’esport com a instrument reforçador del sentiment nacional. Les implicacions dels triomfs de la selecció espanyola de futbol en el discurs de la militància valenciana d’esquerra i centreesquerra

    Directory of Open Access Journals (Sweden)

    Lluís Català Oltra

    2013-12-01

    Full Text Available En aquest treball es repassa primerament el paper que ha tingut l’esport en el reforçament de la identitat nacional. A continuació, centrem l’atenció en el futbol per a parlar de la dinàmica centre-perifèria duta al terreny dels clubs de la Lliga espanyola; i dels èxits de la selecció espanyola i les implicacions per al sentiment nacional. Això últim ens serveix de base per a l’estudi empíric desenvolupat a partir d’entrevistes semiestructurades a militants de base de partits valencians d’esquerra i centreesquerra. Amb aquest material analitzem els discursos dels militants sobre aquestes victòries i la seua relació amb la identitat nacional. | In this work firstly we review the role played by the sport in the reinforcement of national identity. Next, we focus on the football, to talk about the centre-periphery dynamic brought to the terrain of Spanish League clubs; and about the successes of the Spanish national team and their implications for the national feeling. This last serves us as a base for the empirical study developed from semistructured interviews to militants of left-wing and centre-left-wing Valencian parties. With this material we analyse the discourses of the militants about these victories and their relation with national identity.

  15. Rabbit Model of Retinoblastoma

    Directory of Open Access Journals (Sweden)

    Shin Jeong Kang

    2011-01-01

    Full Text Available We created a rabbit model of retinoblastoma and confirmed the tumor clinically and histopathologically. Seventeen New Zealand rabbits were immunosuppressed with cyclosporin A at doses of 10–15 mg/kg. At day 3, the animals received a 30 μl subretinal injection of 1×106 cultured WERI retinoblastoma cells. Digital fundus images were captured before euthanasia, and the eyes were submitted for histopathology. Retinoblastoma cells grew in all the inoculated eyes and established a tumor under the retina and/or in the vitreous. New blood vessels in the tumor were observed starting at week 5. Cuffs of viable tumor cells surrounded the blood vessels with regions of necrosis present at 70–80 μm from nutrient vessels. Occasional tumor seeds in the vitreous histologically exhibited central necrosis. This rabbit model demonstrated similar fundus appearance and pathologic features to human retinoblastoma and may be used as a model to test various routes of drug delivery for retinoblastoma.

  16. Implicaciones en la secuenciación cronológica rupestre del grafismo figurativo mueble gravetiense peninsular

    OpenAIRE

    García Díez, Marcos; Ochoa Fraile, Blanca

    2012-01-01

    [ES] Partiendo de la caracterización del ciclo gráfico mueble figurativo del Gravetiense peninsular (Morín, Antoliñako koba, El Castillo, Les Mallaetes y El Parpalló), se exploran las relaciones gráficas entre cada una de las piezas y los conjuntos rupestres. Se reflexiona sobre el orden cronológico y la dispersión espacial de las similitudes gráficas en el ámbito de la Península Ibérica. Se concluye que el ciclo gráfico gravetiense se caracteriza por un alto grado de normativismo gráfico,...

  17. Implicaciones ambientales del uso de leña como combustible doméstico en la zona rural de Usme / Environmental implications of the use of wood as domestic fuel in the rural area of Usme

    OpenAIRE

    Mejía Barragán, Fabiola

    2011-01-01

    Este trabajo analiza las implicaciones ambientales del uso de la leña como combustible doméstico, tomando como caso de estudio la zona rural de Usme, Bogotá, Colombia, desde tres aspectos: el socio-cultural, el ecosistémico y el tecnológico. A través de trabajo de campo, de encuestas aplicadas y de la información recolectada por experimentación directa en algunas cocinas de la zona, se identificaron los impactos que el uso de la leña para cocción genera sobre la salud, la economía y aspectos...

  18. Implicaciones sociales del gasto de intereses sobre la deuda pública en Costa Rica: una aproximación

    Directory of Open Access Journals (Sweden)

    Rodrigo Matarrita Venegas

    2007-02-01

    Full Text Available LA FORMA EN LA QUE EL GOBIERNO DE LA REPÚBLICA DE COSTA RICA ha ido modificando su deuda pública ha incidido en la definición de un importante peso en cuanto al pago de intereses, lo que ha afectado la acción de Estado en cuanto a la redistribución de la riqueza, favoreciendo la acumulación del capital financiero de los agentes con excedentes de recursos. El documento procura establecer el uso de un par de indicadores como variables aproximadas de este fenómeno.

  19. Implicaciones sociales del gasto de intereses sobre la deuda pública en Costa Rica: una aproximación

    OpenAIRE

    Rodrigo Matarrita Venegas

    2007-01-01

    LA FORMA EN LA QUE EL GOBIERNO DE LA REPÚBLICA DE COSTA RICA ha ido modificando su deuda pública ha incidido en la definición de un importante peso en cuanto al pago de intereses, lo que ha afectado la acción de Estado en cuanto a la redistribución de la riqueza, favoreciendo la acumulación del capital financiero de los agentes con excedentes de recursos. El documento procura establecer el uso de un par de indicadores como variables aproximadas de este fenómeno.

  20. Implicaciones a México a Bloques Comerciales en el Mercado Mundial del Espárrago

    OpenAIRE

    Ramón G. Guajardo Quiroga; Universidad Autónoma de Nuevo León, México

    2005-01-01

    Este artículo estudia el impacto de la formación de bloques comerciales en el comercio mundial del espárrago (NAFTA y TLCUEM). Se construyó un modelo de equilibrio espacial con precios endógenos y se diseñaron varios escenarios, de los cuales se presentan cuatro, con diversos grados de apertura comercial. Los resultados muestran que los productores mexicanos de espárragos resultan favorecidos con la integración de estos bloques. Sin embargo, en el escenario que modela la eliminación total de ...

  1. La sufixació apreciativa del català: creacions lèxiques i implicacions morfològiques

    Directory of Open Access Journals (Sweden)

    Maria-Rosa Lloret

    2015-10-01

    Full Text Available Resum: La situació de la derivació apreciativa dins la morfologia és excepcional, perquè la informació limitada que contenen, en general, les gramàtiques i els diccionaris sobre els apreciatius així com l’ús habitual d’aquestes formes en contextos familiars i informals fan que la creativitat dels parlants no es vegi limitada per normatives i que, per tant, aflorin solucions imaginatives, que, tot i la variació existent, segueixen uns condicionaments gramaticals clars. L’objectiu d’aquest treball és aportar noves dades en aquest camp a partir de formes recollides en corpus tradicionals i per internet, amb una doble finalitat: d’una banda, aprofundir en les particularitats morfològiques de la sufixació apreciativa del català, amb especial interès per les de les categories que la bibliografia sovint ignora (és a dir, els apreciatius que no deriven de noms, adjectius o verbs; i, de l’altra, demostrar que les restriccions distribucionals que presenten els apreciatius amb relació a les terminacions que admeten tant les formes tradicionals com les noves creacions lèxiques permeten redefinir quines marques flexives nominals reals té el català.Paraules clau: derivació apreciativa, neologismes, flexió nominal, marques flexives, gènere, català.

  2. Avistamientos recientes del águila real (Aquila chrysaetos en la Reserva de la Biosfera Sierra Gorda de Guanajuato, México, y sus implicaciones en el plan de manejo de la reserva

    Directory of Open Access Journals (Sweden)

    José Ismael Campos-Rodríguez

    2016-07-01

    Full Text Available Documentamos por primera vez la presencia del águila real (Aquila chrysaetos dentro de la Reserva de la Biosfera Sierra Gorda de Guanajuato (rbsgg en el estado de Guanajuato, México. En mayo de 2015 observamos una pareja de águila real cazando en la localidad de Mesita del Tigre, municipio de Victoria, Guanajuato. Nuestro registro tiene implicaciones en las políticas de uso de suelo contenidas en el Plan de Manejo de la rbsgg, donde sugerimos incluir medidas explícitas de protección del hábitat de la especie y el establecimiento de programas de monitoreo en aquellas subzonas donde se ha registrado al águila real o existe potencial para la anidación de la especie.

  3. Desafíos de la gobernanza ambiental: una aproximación a las implicaciones de la Gestión Integrada del Recurso Hídrico en Colombia

    Directory of Open Access Journals (Sweden)

    Nicolás González

    2017-01-01

    Full Text Available En búsqueda de realizar una aproximación a las implicaciones de la gobernanza del agua en Colombia, este trabajo (1 indaga acerca del concepto en cuestión, (2 su relación con la Gestión Integrada del Recurso Hídrico (GIRH, (3 expone brevemente el marco institucional que soporta el patrón de gestión de aguas vigente en Colombia, (4 lo analiza críticamente y (5 finalmente, presenta algunas consideraciones pertinentes a cerca de las posibilidades y desafíos que, desde las instituciones, supone la implementación de modelos de GIRH en Colombia.

  4. Las implicaciones del conflicto interno colombiano para las fronteras de Ecuador, Perú, Brasil y Venezuela, 2000-2005

    Directory of Open Access Journals (Sweden)

    Moreano Urigüen, Hernán

    2006-01-01

    Full Text Available El artículo describe la situación de las distintas zonas limítrofes de Colombia -Ecuador, Perú, Brasil y Venezuela- en relación a la vigencia del Plan Colombia desde agosto de 2000, y cuyo fin es erradicar los cultivos de hoja de coca y a la vez combatir a los grupos alzados en armas FARC, ELN y AUC. Más allá de lo militar, el texto presenta la situación social y medioambiental en las zonas más vulnerables, y describe una escenario caracterizado por un sinnúmero de desplazados y refugiados sin que existan acuerdos comunes para la prevención de conflictos.

  5. Implicaciones a México a Bloques Comerciales en el Mercado Mundial del Espárrago

    Directory of Open Access Journals (Sweden)

    Ramón G. Guajardo Quiroga

    2005-07-01

    Full Text Available Este artículo estudia el impacto de la formación de bloques comerciales en el comercio mundial del espárrago (NAFTA y TLCUEM. Se construyó un modelo de equilibrio espacial con precios endógenos y se diseñaron varios escenarios, de los cuales se presentan cuatro, con diversos grados de apertura comercial. Los resultados muestran que los productores mexicanos de espárragos resultan favorecidos con la integración de estos bloques. Sin embargo, en el escenario que modela la eliminación total de los aranceles a nivel mundial los resultados muestran que Perú es el más beneficiado, ya que incrementa substancialmente su producción y sus exportaciones.

  6. De los acuerdos del Gatt a la Organización Mundial del Comercio. Implicaciones para América Latina

    OpenAIRE

    Orlando Gutiérrez Rozo

    1998-01-01

    Desde la creación del Acuerdo General sobre Aranceles Gatt en 1947, la liberalización del comercio de mercancías se constituyó en un propósito de primer orden para las relaciones económicas internacionales de la segunda posguerra. Tras ocho rondas de negociaciones multilaterales, atravesadas por no pocas recomposiciones del proceso de acumulación de capital, se creó la Organización Mundial del Comercio -OMC- como expresión de una necesaria institucionalidad supranacional, la cual se propuso r...

  7. Irradiation sequels of retinoblastomas

    International Nuclear Information System (INIS)

    Benk, V.; Habrand, J.L.; Bloch Michel, E.; Soussaline, M.; Sarrazin, D.

    1993-01-01

    From 1975 to 1985, 34 children with a non-metastatic retinoblastoma were irradiated at the Institut Gustave-Roussy. After enucleation, 19 bilateral tumors were irradiated by two lateral opposed fields and 15 unilateral tumors by one lateral and anterior field, in the case of optic nerve being histologically positive. Dose was 45 Gy, 1.8 Gy per fraction. The 10-year-survival rate for unilateral and bilateral retinoblastomas was 79%. Long term sequels were available for 25 patients: 88% retained one functional eye. Three children with bilateral retinoblastomas developed a cataract in the residual eye between 2 and 5 years after irradiation, none with unilateral tumor. Nine patients (36%), seven with unilateral and two with bilateral tumor developed a cosmetical problem that required multiple surgical rehabilitation between 3 and 14 years after irradiation. Nine children (36%), five with unilateral and four with bilateral tumors developed growth hormone deficit between 2 and 8 years after irradiation that required hormone replacement. Their pituitary gland received 22 to 40 Gy. No osteosarcoma occurred in this population. Among long-term sequels, following irradiation for retinoblastoma, cosmetical deformities represent disabling sequels that could justify new approaches in radiotherapy, as protontherapy combined with 3-D-treatment planning

  8. Genetics Home Reference: retinoblastoma

    Science.gov (United States)

    ... Some studies suggest that additional genetic changes can influence the development of retinoblastoma ; these changes may help explain variations ... usually occurs in childhood, typically leading to the development of ... and there is no family history of the disease. Affected individuals are born ...

  9. Concepciónes de los profesionales del derecho sobre delitos sexuales matrimoniales y extramatrimoniales: implicaciones psicosociales

    Directory of Open Access Journals (Sweden)

    Clarissa De Antoni

    2015-02-01

    Full Text Available Este estudio identificó las concepciónes de los operadores jurídicos sobre la violencia sexual marital y extramarital contra los crímenes de las mujeres. Los participantes fueron tres profesionales del Derecho: un Juez, de un fiscal de distrito y un Defensor Público, con edades entre 39 y 47 años de edad y de sexo masculino. Entrevista semiestructurada, abordando los aspectos legales y psicosociales y la presentación de un caso ficticio. Se utilizó el análisis de contenido y criamostres categorías: 1 crímenes sexuales maritales; 2 y los delitos sexuales extramaritales cometidos por extraños; 3 La comparación entre los dos crímenes. Se encontraron diferentes resultados, la más relevante la percepción de que la violación marital es mitigado por el doble enlace , mientras que la parte exterior de la conyugal era visto como algo más agresivo. Se dio cuenta de que las creencias de los operadores jurídicos pueden interferir con el juicio sobre los crímenes sexuales cometidos en el matrimonio.

  10. The Mediated Learning Experience and the Mediator’s Implications La experiencia de aprendizaje mediado y las implicaciones del mediador

    Directory of Open Access Journals (Sweden)

    Fanny Stella Torres Vigoya

    2005-10-01

    Full Text Available It is clear that educators can affect learning positively or negatively, that a personal or professional attitude will immediately change the awareness pupils have toward our classes. Furthermore, as educators, we can not encourage in our pupils the development of good cognitive and socioemotional strategies if we do not constitute ourselves as a model to be followed. On account of these considerations, this article focuses on what Feuerstein (1986 has termed “mediation”, its conditions and the mediator’s profile. Thus, as language teachers, we have to think about the way we could improve and enrich the experience we are offering our pupils in order to make them feel and be intelligent cognitively and emotionally.Es claro que como educadores podemos afectar el aprendizaje de manera positiva o negativa y que una actitud personal o profesional podría cambiar de manera inmediata la disposición que tienen nuestros estudiantes hacia nuestra clase. Además, como educadores no podemos promover en nuestros educandos el desarrollo de estrategias cognitivas y socio-emocionales positivas si nosotros mismos no nos constituimos en un modelo digno de ser seguido. Teniendo en cuenta estas consideraciones, este artículo se enfoca en lo que Feuerstein (1986 llama “mediación”, sus condiciones y el perfil del mediador. Como profesores de idiomas debemos reflexionar acerca de las maneras como podríamos mejorar y enriquecer la experiencia que le estamos ofreciendo a nuestros estudiantes para que ellos se sientan y se hagan inteligentes tanto cognitiva como emocionalmente.

  11. El interrogante de lo vivo y sus respuestas ahistóricas: desarrollo histórico del concepto de lo vivo y algunas implicaciones didácticas.

    Directory of Open Access Journals (Sweden)

    Mónica Correa (Página 153-163

    2009-07-01

    Full Text Available El  presente trabajo muestra  el desarrollo histórico y epistemológico del concepto de lo vivo, en términos de las diferentes corrientes de pensamiento que han guiado su estudio, como son: El animismo, el mecanicismo, el vitalismo, el organicismo, el pensamiento sistémico y el neomecanicismo. Además, relacionando lo  anterior con  la formación docente y buscando una reflexión acerca de la importancia de vincular la historia y la epistemología en la enseñanza de las ciencias, se hace una revisión de algunas  implicaciones  didácticas del abordaje ahistórico de de este concepto en la escuela.

  12. De los acuerdos del Gatt a la Organización Mundial del Comercio. Implicaciones para América Latina

    Directory of Open Access Journals (Sweden)

    Orlando Gutiérrez Rozo

    1998-12-01

    Full Text Available Desde la creación del Acuerdo General sobre Aranceles Gatt en 1947, la liberalización del comercio de mercancías se constituyó en un propósito de primer orden para las relaciones económicas internacionales de la segunda posguerra. Tras ocho rondas de negociaciones multilaterales, atravesadas por no pocas recomposiciones del proceso de acumulación de capital, se creó la Organización Mundial del Comercio -OMC- como expresión de una necesaria institucionalidad supranacional, la cual se propuso reglamentar el proceso de una liberalización que ya se trascendía a las mercancías. Los programas de liberalización de productos agrícolas, así como lo referente a los textiles y confecciones, no fueron suficientes para los imperativos expansivos del comercio y del capital. Así pues, la Ronda Uruguay del Gatt debería abordar los llamados "nuevos temas", lo cual expresa tanto el papel que ellos desempeñan en la productividad y el comercio, como los intereses de las grandes empresas y de los países industrializados. El creciente rol de los servicios en la economía mundial, la necesidad de reglamentar en un gran acuerdo el régimen de propiedad intelectual y la consecuente liberalización de las inversiones extranjeras, condujeron a largos procesos de negociación internacional. Debatir la naturaleza, el carácter y el contexto económico en el cual se inscriben los acuerdos alcanzados sobre estas materias en torno a la OMC, constituyen los ejes temáticos de este artículo.

  13. Implicaciones sedimentológicas sobre el cambio en la cobertura del bosque de manglar en Boca Zacate, Humedal Nacional Térraba-Sierpe, Costa Rica

    Directory of Open Access Journals (Sweden)

    Ana Margarita Silva Benavides

    2015-09-01

    Full Text Available Resumen:En los últimos sesenta años han ocurrido cambios en el Humedal Nacional Térraba-Sierpe, Costa Rica. Los cambios en la geomorfología costera están asociados a la erosión o acreción de sedimentos, lo que ha favorecido la eliminación de sectores de bosque o a la formación de bancos de sedimentos que han sido colonizados por árboles de mangle. El estudio se realizó en los sectores Bocón, Brujo e isla Coco en Boca Zacate, Humedal Nacional Térraba-Sierpe, Costa Rica, entre 2008-2013, cuyo objetivo consiste en analizar el aporte de sedimentos y las implicaciones en la cobertura del bosque de mangle en el sector de Boca Zacate. Es este estudio se realizó un análisis multitemporal de la morfología litoral con fotografías aéreas e imágenes satelitales de 1948, 1960, 1974, 1978, 1984, 1992 y 2011. Y además, se cuantificó la tasa de sedimentación mensual (g/cm2/día en los canales de los estuarios, la composición granulométrica y la concentración de elementos químicos en los sedimentos (mgL-1 en época seca y lluviosa durante los años de estudio. Los resultados indican que Boca Zacate ha mantenido en los últimos 60 años una tendencia hacia la erosión, perdiendo un 10.6 % de su espacio emergido entre 1948 y 2011 y aproximadamente un 8.9 % de su cobertura forestal; también ha experimentado una acreción en la zona de la isla Coco, uniéndose al continente por este sector. La tasa de sedimentación cuantificada en los esteros presentó diferencias con respecto al sitio y a la época. La mayor cantidad se presentó en el estero el Brujo y la menor cantidad en el estero Camíbar. Con respecto a la granulo-metría, el tipo de sedimento dominante es la arena, seguido por la arcilla y en menor cantidad el limo en todos los sitios de estudio. La mayor distribución de los elementos químicos corresponde al magnesio, calcio, potasio; mientras que el manganeso, hierro, aluminio, fósforo, zinc y cobre se encontraron en menor

  14. Radiation management of retinoblastoma

    International Nuclear Information System (INIS)

    Takemasa, Kazuhiko; Ito, Hisao; Nishiguchi, Iku; Hashimoto, Shozo; Tanaka, Yasuhiko; Oguchi, Yoshihisa

    1992-01-01

    Forty-five patients with retinoblastoma were treated at Keio University Hospital from 1970 to 1990. Thirty-two patients had unilateral lesions and 13 had bilateral lesions. Twenty-nine patients with unilateral and 12 with bilateral lesions underwent enucleation for advanced tumor. As a result, 3 patients with unilateral retinoblastoma and all patients with bilateral disease were treated with radiotherapy (40-50 Gy) combined with or without cryotherapy and/or photocoagulation. One patient with unilateral lesion treated with radiotherapy and chemotherapy had metastases at the first visit to our clinic and was excluded from this analysis. Among 16 eyes (15 patients) treated with radiotherapy, 6 eyes had recurrence and needed retreatment. Cataract occurred in 6 of 12 eyes and good vision was preserved in 5 of 10 eyes in which function could be evaluated. (author)

  15. Radiation management of retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Takemasa, Kazuhiko; Ito, Hisao; Nishiguchi, Iku; Hashimoto, Shozo; Tanaka, Yasuhiko; Oguchi, Yoshihisa (Keio Univ., Tokyo (Japan). School of Medicine)

    1992-06-01

    Forty-five patients with retinoblastoma were treated at Keio University Hospital from 1970 to 1990. Thirty-two patients had unilateral lesions and 13 had bilateral lesions. Twenty-nine patients with unilateral and 12 with bilateral lesions underwent enucleation for advanced tumor. As a result, 3 patients with unilateral retinoblastoma and all patients with bilateral disease were treated with radiotherapy (40-50 Gy) combined with or without cryotherapy and/or photocoagulation. One patient with unilateral lesion treated with radiotherapy and chemotherapy had metastases at the first visit to our clinic and was excluded from this analysis. Among 16 eyes (15 patients) treated with radiotherapy, 6 eyes had recurrence and needed retreatment. Cataract occurred in 6 of 12 eyes and good vision was preserved in 5 of 10 eyes in which function could be evaluated. (author).

  16. Radiation management of retinoblastoma

    International Nuclear Information System (INIS)

    Takemasa, Kazuhiko; Ito, Hisao; Hashimoto, Shozo; Tanaka, Yasuhiko; Oguchi, Yoshihisa

    1991-01-01

    An analysis has been conducted of 45 patients treated for retinoblastoma at Keio University Hospital between 1970 and 1990. Of these patients, 32 had unilateral lesion and 13 had bilateral lesion. Further, since their disease was far advanced, 29 patients with unilateral lesion and 12 patients with bilateral lesion underwent enucleation. As a result, 3 patients with unilateral retinoblastoma and all patients with bilateral manifestation of the disease were treated with radiotherapy (45-50 Gy) with or without cryotherapy and photocoagulation. One patient with unilateral lesion, who had received both radiotherapy and chemotherapy, showed metastases at the first presentation at our clinic and thus was excluded from this analysis. Among 16 eyes of 15 patients who were given radiotherapy, 6 eyes developed recurrence and needed to have further treatment. In 6 eyes out of 12, cataract developed, and out of 10 eyes in which eye function was evaluable, good vision was able to be preserved in 5 eyes. (author)

  17. Histología y morfometría del ojo del pez de Ariopsis seemanni: Implicaciones en ecología visual

    OpenAIRE

    Tovar Bohórquez, Mario Oswaldo; Corchuelo Chavarro, Sheryll Yohana; Gómez Ramírez, Edwin; Obando Bulla, Martha Janneth; Hurtado Giraldo, Hernán

    2013-01-01

    Teniendo en cuenta la importancia del sistema visual en la vida de los organismos, en el presente trabajo se hace una descripción histológica y morfométrica del ojo de juveniles de Ariopsis seemanni, una especie de teleósteo ornamental comercialmente importante, con un enfoque hacia su ecología visual. El ojo de A. seemanni tiene la conformación típica de los teleósteos, con un tamaño relativo grande (TRO=6.5%) y un cristalino circular también relativamente grande (TRC=42.2%). La córnea está ...

  18. Problemas conceptuales y metodológicos del índice de fragilidad ambiental y sus implicaciones para la valoración del riesgo en el ordenamiento territorial en Costa Rica

    Directory of Open Access Journals (Sweden)

    Barrantes Castillo, Gustavo

    2016-06-01

    Full Text Available La inclusión de la gestión del riesgo en el ordenamiento territorial es una consigna que se ha intentado implementar en Costa Rica. No obstante, el procedimiento para hacer planes reguladores de uso del suelo en el país está atado a lo establecido en la legislación vigente. En el tema de la consideración del ambiente en la planificación territorial en particular, se destaca el decreto Nº32967-MINAE Manual de Instrumentos Técnicos para el Proceso de Evaluación de Impacto Ambiental (2006, el cual introduce un modelo de valoración ambiental (y de las amenazas naturales que aparenta sustentarse en un enfoque epistemológico racionalista-deductivo. Dado que parte de una concepción del funcionamiento de la naturaleza como un mecanismo donde la suma de las partes representa el todo, además, de introducir imprecisiones conceptuales y errores metodológicos. Estos aspectos son los que se tratan en el presente artículo, en relación directa con sus implicaciones para la disminución de los desastres en Costa Rica The inclusion of risk management in Land Management is a slogan that has tried to implement in Costa Rica. However, the procedure for regulators Plans Land Use in the country is tied to the provisions of the legislation. On the issue of considering the Environment in territorial planning in particular decree No. 32967-MINAE: "Manual of Technical Instruments for the process of Environmental Impact Assessment", which introduces a model of environmental assessment (and natural hazards, that appears based on a rationalist deductive epistemological approach. Where of the nature operation as a mechanism where the sum of the parts represents the whole, in addition to introducing inaccuracies conceptual and methodological errors. These aspects are developed in this article related to their implications for the reduction of disasters in Costa Rica

  19. Implicaciones paleoambientales deducidas del estudio geoquímico del transito mioceno-plioceno en la Cuenca de Sorbas (Almería

    Directory of Open Access Journals (Sweden)

    Sebastián Pardo, E.

    1995-08-01

    Full Text Available The geochemistry of the Se ha realizado un estudio geoquímico de la fracción arcillosa de los sedimentos miopliocenos y de la muestra total de rocas metamórficas de los relieves adyacentes con el fin de determinar las características geoquímicas del medio de sedimentación y la influencia de las rocas circundantes sobre los sedimentos. Tras relacionar elementos químicos con rocas y minerales mediante un (ACP, se ha realizado una clasificación jerárquica ascendente (CJA, que ha reagrupado las muestras con características geoquímicas similares en 8 clases. La comparación gráfica de su composición geoquímica media pone de manifiesto una clara relación genética entre los sedimentos y las rocas metapelíticas de la Cordillera Bética oriental, siendo la influencia de gneises, rocas carbonatadas metamórficas y metabasitas muy localizada o inexistente. Finalmente, los contenidos de B y Mg nos han permitido distinguir varios tipos de medios de depósito que presentan diferentes grados de confinamiento y que, en relación con los cambios del nivel del mar producidos durante la crisis messiniense, se han visto influenciados sucesivamente por aguas marinas y continentales.

  20. Retinoblastoma: a most unusual presentation

    African Journals Online (AJOL)

    Dr. C. Pedro-Egbe

    Although leukocoria and strabismus are the most common presenting signs of retinoblastoma, a retrospective study by Abramson et al. identified 32 distinct presenting signs of retinoblastoma.6-8. A few other studies have also noted some distinct characteristics exhibited by children whose conditions were diagnosed in the ...

  1. Implicaciones del filtrado de calidad del índice de vegetación EVI para el seguimiento funcional de ecosistemas

    Directory of Open Access Journals (Sweden)

    A. Reyes-Díez

    2015-06-01

    Full Text Available El seguimiento de los ecosistemas con imágenes procedentes del sensor MODIS (Moderate Resolution Imaging Spectroradiometer, espectroradiómetro de imágenes de resolución media está actualmente muy extendido tanto en tareas de investigación como de gestión. Los índices de vegetación NDVI (Normalized Difference Vegetation Index, índice de vegetación de la diferencia normalizada y EVI (Enhanced Vegetation Index, índice de vegetación mejorado son ampliamente usados para la caracterización del funcionamiento ecosistémico. Ambos índices se emplean como estimadores lineales de la fracción de radiación fotosintéticamente activa interceptada por la vegetación (fAPAR, el principal control de la producción primaria. A pesar de sus ventajas, las imágenes de índices de vegetación no están libres de errores. El producto índices de vegetación MOD13Q1 proporciona una capa QA (Quality assessment,evaluación de la calidad que informa sobre la calidad asociada a cada píxel. Esta información representa una gran ventaja para el usuario, al permitir filtrar aquellos datos que puedan inducir a errores al verse alterados por la presencia de aerosoles, nubes, nieve o sombras. Sin embargo, la realización de un filtrado homogéneo a lo largo de una gran región puede ocasionar la pérdida sistemática de información en determinadas zonas o épocas del año, introduciendo así un sesgo espacial o en la serie temporal. Esta situación puede ser especialmente crítica en regiones con alta heterogeneidad ambiental, como el Sureste Ibérico. En este trabajo evaluamos el efecto que el filtrado de calidad tiene sobre la información espacial y temporal de la base de datos del EVI en el periodo 2001-2010. Los esultados, expresados en porcentaje de información perdida (filtrada y como efecto de estas pérdidas sobre los valores del EVI, indican que mientras que las áreas de menor altitud no se ven afectadas por el filtrado, las regiones de alta

  2. Tratamiento conservador en pacientes con retinoblastoma bilateral

    Directory of Open Access Journals (Sweden)

    Juan C. Suárez

    2008-11-01

    Full Text Available OBJETIVO: comparar el tratamiento convencional del retinoblastoma bilateral, usado hasta hace algunos años, consistente en radioterapia o enucleación bilateral, con el tratamiento conservador actual que incluye termoterapia transpupilar (TTT o TTT/quimioterapia al menos en un ojo, en niños con diagnóstico de retinoblastoma bilateral. DISEÑO: estudio retrospectivo descriptivo. MUESTRA: 20 pacientes con diagnóstico de retinoblastoma bilateral que consultaron al Hospital Universitario San Vicente de Paúl, de Medellín, Colombia, entre 1997 y 2007. MÉTODO: se hizo enucleación del ojo con el tumor de mayor tamaño. En el otro ojo se hizo tratamiento con TTT, con el láser diodo (810 nm, spot amplio, solo o combinado con otras terapias. RESULTADOS: se dividió a los pacientes en dos grupos: 16 pacientes (32 ojos en el grupo 1 tratados conservadoramente y 4 pacientes (8 ojos en el grupo 2 con tratamiento convencional. El rango de edad fue de 1-72 meses en el grupo 1 y de 1-12 meses en el grupo 2. El tiempo de seguimiento fue de 7-67 meses para el grupo 1 y de 13-73 meses para el grupo 2. En el grupo 1 se hizo enucleación de 16 ojos (50%, radioterapia externa de uno (3,1%, quimioterapia más termoterapia de 5 (15,6% y quimioterapia más termoterapia más crioterapia de 10 (31,3%. En todos los pacientes se logró preservar al menos un ojo. En el grupo 2, se enuclearon 7 ojos (87,5% y se hizo radioterapia externa más enucleación en un paciente (12.5%. Además, todos los pacientes recibieron quimioterapia. CONCLUSIÓN: la terapia conservadora actual consistente en tratamiento local (termoterapia, crioterapia o braquiterapia y quimiorreducción permite preservar al menos un ojo y en algunos casos de los dos, muchas veces con buena agudeza visual, en niños con retinoblastoma bilateral; se evitan así la enucleación bilateral y la radioterapia externa usada en el tratamiento convencional con todos sus efectos secundarios. La enucleación contin

  3. Ultrasonographic findings of retinoblastoma

    International Nuclear Information System (INIS)

    Chung, Sung Hoo; Kang, Ik Won; Park, Yang Hee; Kim, Chu Wan; Chi, Je Geun

    1982-01-01

    Retinoblastoma is the most common intraocular tumor in infants and young children which has relatively favorable prognosis with early diagnosis and adequate treatment, however, it can be lethal if the treatment is delayed or inadequate. Clinically, early diagnosis is often difficult because of minimal subjective and objective signs and symptoms, and the patients are usually too young to complain visual disturbance. When ophthalmoscopicexamination is impossible due to presence of opaue media in front of tumor mass as associated inflammatory reaction, hemorrhage, corneal opacity, retinal detachment, etc, ultrasonography is necessary for diagnosis of retinoblastoma. Authors analyzed ultrasonographic al findings with pathological correlation on 10 cases of confirmed retinoblastoma during the period of March 1981 to September1982 at the Seoul National University Hospital. In all cases, ultrasonography demonstrates intraocular masses and all of which are cystic type.Reflectivity of masses are higher than retroorbital fat tissue in 8 cases, and 7 cases show irregular internal echogenic texture. There is no correlation between reflexivity and internal echogenic texture with microscopic findings as rosette, pseudo rosette and micro cysts. Calcifications are demonstrated by ultrasonography as strong reflectiveness with posterior sonic shadowing in 9 cases and 9 of 10 cases are well correlated with calcifications in pathologic specimens. Anechoic cystic areas are shown in 9 cases, and 6 of 10 cases are well correlated with necrosis in pathologic specimen. In all cases, there is no attenuation of sound within tumor masses, and no demonstrable choroidal excavation. Associated retinal detachment is hardly identifiable in irregular contour and internal texture of cystic tumor masses

  4. Radiotherapy for retinoblastoma

    International Nuclear Information System (INIS)

    Murayama, Shigeyuki; Kagami, Yoshikazu; Tokuue, Koichi; Sumi, Minako; Ikeda, Hiroshi; Kaneko; Akihiro

    1999-01-01

    A retrospective chart review was made of the patients with retinoblastoma received eye conservative therapy between 1980 and 1992. Of 112, 77 had bilateral disease and 35 had unilateral disease. A definitive external radiation therapy (ERT) was used in 106 eyes and ERT combined with concurrent or adjuvant therapy in 29 eyes. Five-year cumulative eye-ball conservation rate for Reese-Ellsworth classification group I to V were 95%, 95.5%, 93.3%, 100% and 58.5%, respectively. Useful vision (>0.01) was maintained in 90.2% of 61 eyes which were treated by definitive ERT initially and experienced no local recurrence. (author)

  5. Análisis e implicaciones del impacto del movimiento MOOC en la comunidad científica: JCR y Scopus (2010-13

    Directory of Open Access Journals (Sweden)

    Pedro Román Graván

    2015-01-01

    Full Text Available La irrupción de los MOOC (Massive Online Open Courses ha supuesto un punto de inflexión en el mundo académico y, especialmente, en el diseño y oferta de cursos formativos en la Educación Superior. Una vez superado el primer momento de explosión informativa, se precisan análisis rigurosos sobre la repercusión del movimiento en el mundo científico con más alto impacto para valorar el estado de la cuestión y las líneas de investigación futuras. El presente estudio analiza el impacto del movimiento MOOC en forma de artículo científico durante el período de nacimiento y explosión (2010-2013 en dos de las bases de datos de revistas científicas más relevantes, Journal Citation Reports (WoS y Scopus (Scimago. A través de una metodología descriptiva y cuantitativa se presentan los datos bibliométricos más significativos por su índice de cita y repercusión. Asimismo, mediante la metodología de Análisis de Redes Sociales (ARS se realiza un análisis de co-ocurrencia con representación en grafo de las palabras clave de los artículos para la determinación de los campos de estudio e investigación. Los resultados muestran que tanto el número de artículos publicados en ambas bases de datos como las citas que reciben presentan un índice medio-bajo de impacto y la red temática de interrelaciones en los resúmenes y palabras clave de los artículos publicados no reflejan la crítica actual de los medios divulgativos generales.

  6. Tumours following retinoblastoma radiotherapy

    International Nuclear Information System (INIS)

    Mollot, J.-P.

    1978-01-01

    Radioinduced tumours in young patients irradiated in childhood for retinoblastoma take on a particularly deadly aspect. The onset of this true clinical entity characterized by a long post-irradiation latency period induced by a dose above 6000 rads is a real tragedy. The vast majority of patients then enter into a long martyrdom ending in death. The only cure is surgical, but seldom possible. Treatment is limited to palliative radiotherapy, effective for a while, and chemiotherapy as a last resort but often difficult to prescribe. Prevention alone is the answer. The quality and reliability of the radiotherapeutic treatment depend not only on the personal talent of the radiotherapist but above all on the standard of the equipment. A strong reduction in the doses employed as well as recent technological progress improving the material, its precision and reproducibility appear already to have lowered the frequency curve of these fatal radioinduced tumours [fr

  7. Nuevas perspectivas sobre las culturas botánicas precolombinas de Puerto Rico: implicaciones del estudio de almidones en herramientas líticas, cerámicas y de concha

    Directory of Open Access Journals (Sweden)

    Jaime R. Pagán Jiménez

    2009-11-01

    Full Text Available El presente artículo muestra una síntesis de la información arqueobotánica más reciente para Puerto Rico proveniente del estudio de granos de almidón recuperados en artefactos arqueológicos. Dichos artefactos, así como los almidones antiguos presentes en ellos debido a la maceración, a la molienda o a la cocción de órganos vegetales, se ubican cronológicamente en casi todos los períodos culturales precolombinos hasta ahora definidos para la isla. Se discuten brevemente las implicaciones de los resultados arqueobotánicos logrados en torno a tres tópicos altamente generalizados y aceptados en nuestra región, pero actualmente cuestionados: a el carácter de las culturas botánicas de los llamados cazadores-pescadores-recolectores, b la atribuida importancia de la yuca para los pueblos agroceramistas antillanos de origen continental y c la generalizada percepción que se tiene acerca del protagonismo que tuvieron plantas como la yuca y el maíz en el desarrollo de las complejidades culturales tardías de las islas antillanas.

  8. Implicaciones clínicas y asistenciales de la nueva clasificación DSM 5 para trastorno del espectro autistas

    OpenAIRE

    Romero González, Marina

    2015-01-01

    OBJETIVOS 1. Estudiar el cumplimiento de los nuevos criterios diagnósticos para Trastorno del Espectro Autista recogidos en el DSM 5 en una muestra de pacientes escolarizados y diagnosticados de Trastorno General del Desarrollo del DSM IV-TR. 2. Estudiar la clasificación de los diferentes subtipos en pacientes diagnosticados con Trastorno General del Desarrollo del DSM IV-TR (Autismo, Síndrome de Asperger y Trastorno general no especificado) entre los pacientes que cumplían los crite...

  9. A transgenic mouse model for trilateral retinoblastoma

    NARCIS (Netherlands)

    O'Brien, J.M.; Marcus, D.M.; Bernards, R.A.; Carpenter, J.L.; Windle, J.J.; Mellon, P.; Albert, D.M.

    1990-01-01

    We present a murine model of trilateral retinoblastoma. Ocular retinoblastoma and central nervous system tumors are observed in a line of mice formed by the transgenic expression of SV40 T-antigen. An oncogenic protein known to bind to the retinoblastoma gene product (p105-Rb) is specifically

  10. La hipótesis del trauma en el abuso sexual: revisión crítica e implicaciones

    Directory of Open Access Journals (Sweden)

    Agustín Malón Marco

    2008-01-01

    Full Text Available Se lleva a cabo una revisión crítica de la hipótesis traumática en el estudio de las experiencias eróticas tempranas con personas más mayores. Esta hipótesis, la más habitual en la literatura científica, consiste en dar por cierto que son en su mayoría experiencias graves y de serias consecuencias negativas a corto y/o largo plazo. Cuestionaremos su fundamentación empírica, para después pasar a las implicaciones científicas y profesionales surgidas de otra lectura de los datos disponibles. Para ello se analizan críticamente nueve revisiones previas sobre la cuestión, publicadas entre 1981 y 1998. Esta revisión de revisiones sugiere que estaría perfectamente sustentada la hipótesis de que en la gran mayoría de los casos no suelen producirse daños serios ni mucho menos permanentes en los implicados. El análisis invita a un replanteamiento teórico, epistemológico y tecnológico de la investigación y la intervención social.

  11. Alteraciones de la Personalidad Asociadas a las Conductas Adictivas: Influencia de la Duración del Consumo y sus Implicaciones Personality Disorders Associated With Addictive Behaviour: Examining the Influence of the Drug Addiction Course and its Implications

    Directory of Open Access Journals (Sweden)

    Jesús Herrero

    2004-05-01

    Full Text Available El fenómeno de la comorbilidad es un aspecto cada vez más estudiado dentro del ámbito psicopatológico. En el campo de las toxicomanías, diferentes estudios señalan una alta prevalencia de distintos trastornos de personalidad en esta población. El objetivo de la presente investigación se centró en analizar la relación existente entre distintos trastornos de personalidad y la duración de consumo de tóxicos. La muestra de sujetos consistió en 1094 toxicómanos que fueron evaluados en una unidad de rehabilitación y tratamiento (Comunidad Terapéutica de Proyecto Hombre. A todos los participantes se les administró individualmente la versión española del Inventario Clínico Multiaxial de Millon (MCMI-II. Se presentan las dificultades del estudio de la relación entre duración de la adicción y personalidad, y se discute las implicaciones clínicas de este trabajo.Comorbidity is a central aspect in current psychopathology. In the field of drug addictions, different studies have shown a high prevalence of personality disorders in this population. The goal of the present investigation was centered on analyzing the relation between different personality disorders and the consumption duration. The subjects were 1094 drug addicts that were evaluated in a rehabilitation and treatment unit (Proyecto Hombre's Therapeutic Community. Personality disorders were ascertained using the Millon Clinical Multiaxial Inventory II Spanish version (MCMI-II. The difficulties of studying the relation among duration of addiction and personality are presented, and clinical implications of study findings are discussed.

  12. Implicaciones de la resolución espacial sobre la estimación de modelos de distribución, evaluación de hábitat y cuotas de aprovechamiento del chigüiro (Hydrochaerus hydrochaeris), en las sabanas inundables de la Orinoquía Colombiana

    OpenAIRE

    Sarmiento Pinzón, Carlos Enrique

    2011-01-01

    Evaluamos diferentes aspectos relativos a la escala espacial que pueden influir sobre la variabilidad, precisión y confiabilidad de los modelos de distribución geográfica (presencia y densidad) del chigüiro en las Sabanas Inundables de la Orinoquía Colombiana. Dichos aspectos abarcan la resolución espacial y cubrimiento geográfico de las variables independientes y de las localidades de presencia y abundancia, así como las posibles implicaciones del uso de imágenes satelitales de diferente re...

  13. Innovation through Joint Ventures. Implications and Role of the Top Management Team Innovación a través de Joint Ventures. Implicaciones y papel del Equipo de Alta Dirección

    Directory of Open Access Journals (Sweden)

    Andrea Ruiz Restrepo,

    2009-06-01

    Full Text Available Although equity-based arrangements, particularly Joint Ventures, are more effective than the contractual ones when trying to have access to knowledge needed for innovation, research on the factors on how to successfully achieve the development and implementation of this strategy is scarce and scattered. From the Upper Echelon Theory, the objective of this work is to develop a review and integration of the literature about shared control Joint Ventures, top management teams and innovation and to propose a framework of relationships. The role and implications of the top management team in carrying out a Joint Venture created to innovate is analyzed in this article, having as a conclusion that the diversity of the TMT (top management team can positively or negatively influence the results of such innovation. The directive nature of their work in relation to the parent companies may hinder the achievement of the objectives for which they were created. Other factors that may help correct the negative implications about innovation, created by the team composition and the characteristics of their work, are also considered.Aunque los acuerdos basados en capital, especialmente las Joint Ventures, son más efectivos que los contractuales a la hora de acceder al conocimiento necesario para la innovación, la investigación sobre los factores favorables al éxito en el desarrollo y consecución de esta estrategia es escasa y dispersa. A partir de la Upper Echelon Theory, el objetivo de este trabajo es desarrollar una revisión e integración de las literaturas sobre Joint Ventures de control compartido, equipos de alta dirección e innovación y proponer un marco de relaciones. Se analiza el papel y las implicaciones del equipo de alta dirección en el desempeño de una Joint Venture creada para innovar. Se concluye que la diversidad de los EAD puede incidir positiva o negativamente en los resultados de tal innovación. Las características de su labor

  14. Retinoblastoma – to expand awareness

    African Journals Online (AJOL)

    lead to delay in diagnosis, possibly loss of vision or even loss of life. Both the public and ... These retinoblastomas show altered gene copy number ... and an examination under anaesthesia, in which the number, size and location ... effects than external beam radiotherapy but is not ... attention to arrival at the unit. Advanced.

  15. modes of presentation, management and outcome of retinoblastoma

    African Journals Online (AJOL)

    SITWALA COMPUTERS

    and short-term outcomes of retinoblastoma treatment at ... incidence of retinoblastoma during the HIV period. Apart .... differentiated retinoblastoma. .... The Zambian health delivery ... the guardian from home and the extra cost of hospital stay.

  16. Adaptación de asignaturas seleccionadas de la titulación de Logopedia a créditos ETCS. Implicaciones del alumnado

    Directory of Open Access Journals (Sweden)

    Natalia JIMENO BULNES

    2005-01-01

    Full Text Available Se presenta una primera experiencia práctica en el marco del proceso de Convergencia Europea de la enseñanza. El proyecto nace con el objetivo de adaptar asignaturas seleccionadas del actual plan de estudios de la Titulación (Diplomatura de Logopedia al reciente "Sistema de Transferencia de Créditos Europeos" (créditos ECTS o European Credit Transfer System. Con este fin se crea una red de carácter nacional en la que participan la Universidad de Valladolid, Salamanca y Castilla-La Mancha. En la presente comunicación se explican de forma exhaustiva diversos aspectos relacionados con la elaboración del proyecto: selección de asignaturas, implicación de profesorado y alumnado, así como la programación de actividades y acciones que se están llevando a cabo actualmente.

  17. IMPLICACIONES FILOSÓFICAS CONTEMPORÁNEAS EN BIOLOGÍA SOBRE LA DIDÁCTICA DE LA BIOLOGÍA: ESTADO DEL ARTE EN CONSTRUCCIÓN

    OpenAIRE

    Germán Chaves

    2015-01-01

    El presente escrito muestra los resultados parciales de la construcción de un estado del arte referido a las relaciones entre la Filosofía de la Biología y su didáctica  como un potencializador de la enseñanza de la misma que hacen parte de una investigación doctoral. Lo anterior a partir de los avances en la revisión bibliográfica, los cuales son parte esencial en  la construcción del estado del arte de la investigación, en la que se resalta el papel de la Filosofía de las Ciencias en su ens...

  18. Murciélagos de cola corta (Carollia: Phyllostomidae del Parque Nacional Natural Gorgona (Colombia y sus implicaciones biogeográficas

    Directory of Open Access Journals (Sweden)

    Oscar E Murillo-García

    2014-02-01

    Full Text Available La identidad de la especie de Carollia (Chiroptera: Phyllostomidae en el Parque Nacional Natural Gorgona ha sido controvertida debido a la alta similitud entre C. perspicillata y C. brevicauda. C. perspicillata es la especie con mayor probabilidad de habitar en la isla debido a que actualmente se distribuye en las tierras bajas de la costa pacífica colombiana, mientras C. brevicauda es una especie predominantemente de tierras altas. Con el objetivo de resolver la controversia acerca de la especie del género Carollia que habita la isla, se realizaron análisis morfométricos con base en característica de cráneos y mandíbulas de especímenes de las dos especies y del PNN Gorgona. Los resultados evidenciaron que, contrario a lo esperado, esta población insular es morfológicamente más similar a C. brevicauda. Evidencia biológica para diferentes grupos de organismos sugiere que Gorgona puede haber estado conectada a los andes y las zonas bajas del pacífico del sur de Colombia-norte de Ecuador en el pasado. Por otra parte, existe evidencia geológica que muestra que Gorgona es la parte más alta de una cordillera (Cordillera de la Costa que se encuentra sumergida actualmente, pero que probablemente fue parte del continente durante el Pleistoceno. Por lo tanto, con base en esta evidencia biológica y geológica se plantea la hipótesis de una ruta de colonización de C. brevicauda a Gorgona desde los Andes a través de la Cordillera de la Costa. Este proceso pudo facilitarse por el descenso marino durante las glaciaciones del Pleistoceno.

  19. Implicaciones de la emisión de gases de efecto invernadero en la sostenibilidad del Campus de Vegazana, Universidad de León

    OpenAIRE

    Arroyo Hernández, Paula; Álvarez Martínez, J.M.; Falagán Fernández, J.; Martínez Sanz, C.; Ansola González, G.; De Luis Calabuig, E.

    2010-01-01

    En este trabajo se presentan los resultados del estudio de emisiones de CO2, uno de los gases más importantes de efecto invernadero, debido a la actividad desarrollada en el Campus de Vegazana de la Universidad de León, para el año 2006. El estudio se enmarca en un proyecto más amplio de cálculo del indicador Huella Ecológica (HE), desarrollado para conocer en qué medida se alcanzan los objetivos de sostenibilidad establecidos para el Campus, así como para el desarrollo de propuestas encam...

  20. Papel del sistema cannabinoide endógeno en el alcoholismo: implicaciones fisiológicas y terapéuticas

    OpenAIRE

    Rubio Gómez, Marina

    2011-01-01

    Numerosas evidencias (genéticas, bioquímicas y farmacológicas) relacionan al sistema cannabinoide en ciertas áreas del cerebro con el desarrollo del alcoholismo. Sin embargo, existen diferentes aspectos de esta relación que no han sido aún completamente esclarecidos. En base a esta idea se ha definido la hipótesis central de esta tesis doctoral, que pretende de forma global profundizar en las bases bioquímicas y farmacológicas que sustentan que el sistema cannabinoide tiene una función en los...

  1. Dinámica espacio-temporal del esfuerzo en una pesquería de buceo artesanal multiespecífica y sus efectos en la variabilidad de las capturas: Implicaciones para el manejo sostenible

    Directory of Open Access Journals (Sweden)

    Helven Naranjo Madrigal

    2014-12-01

    consumo personal, incluyendo especies de alto valor comercial. Se identificaron cambios en las estrategias de pesca asociadas a cambios en las capturas y cambios en la asignación espacial del esfuerzo pesquero de una temporada de pesca a otra, definidas por la adición de buceo nocturno, aumento en el número de inmersiones de una temporada a otra y procesos de cooperación en las faenas de pesca de buzos que usan buceo libre. Se discute las potenciales causas de los cambios en las estrategias de pesca observadas y se derivan implicaciones para el manejo que permiten la sostenibilidad de estas pesquerías a largo plazo.

  2. Estado poblacional del orden Plecoptera (Insecta en el Parque Nacional Sierra Nevada en Venezuela y sus implicaciones para planes de conservación

    Directory of Open Access Journals (Sweden)

    Maribet Gamboa

    2010-12-01

    Full Text Available La distribución longitudinal de las especies de plecópteros fue examinada a lo largo del Parque Nacional Sierra Nevada en la región Andina del estado Mérida, Venezuela. El PNSN es uno de las más grandes regiones protegidas y abarca dos subcuencas hidrográficas importantes. Muestras cuantitativas fueron recolectadas en 7 ríos tributarios de estas cuencas a lo largo del PNSN desde febrero a mayo del 2009, con un total de 135 individuos de 4 especies del género Anacroneuria. Sólo en tres ríos (Nuestra Señora, La Picón y Corcovada se encontró la presencia de plecópteros, los análisis de componentes principales muestran que la caracterización del hábitat, la velocidad de la corriente, el oxígeno disuelto y la ausencia de fuentes de perturbación antrópica influyen en un hábitat idóneo para las poblaciones. Los plecópteros se hallan en peligro de desaparición o incluso se han llegado a extinguir en gran parte de su área de distribución como consecuencia de actividades humanas. Planes de conservación deben ser implementados con urgencia, como evitar zonas recreacionales y/o económicas en las cercanías de los mismos.Population status of insects of Plecoptera order in Sierra Nevada National Park in Venezuela and its implications for conservation planning. Longitudinal distribution of Plecoptera species were examined along the Sierra Nevada National Park in the Andean region of Merida State, Venezuela. PNSN is one of the largest protected areas and consists of two major sub-basins. Quantitative samples were collected in 7 river tributaries along the PNSN from February to May of 2009, and a total of 135 individuals and 4 species of the genus Anacroneuria were collected. Only three rivers (Nuestra Señora, La Picón y Corcovada found the presence of stoneflies, the principal component analysis show that the characterization of habitat, current velocity, dissolved oxygen and the absence of human disturbance sources of influence in

  3. Adjusting of the power-factor correction. Technical, economic and financial implications; Calculo de correccion del factor de potencia. Implicaciones tecnicas, economicas y financieras

    Energy Technology Data Exchange (ETDEWEB)

    Eficiencia Energetica aplicada (Energiza) [Ciudad Juarez, Chihuahua (Mexico)

    2005-07-01

    A power-factor is a device formed by a dielectric set and electrodes within a container with terminals, able to contribute with capacitance to an electrical circuit, such as: transformers, induction motors, regulators, air conditioning, welding machines, induction furnaces and ballasts. This document also tells us about the location of capacitors in their system, the electrical conductor, the monthly consumption electricity bill, of the benefits when adjusting the power-factor, the liberation of power of the transformer, the reduction of current in feeders, the reduction of losses in feeders, the diminution of the tension fall and the approximate average sale price. [Spanish] Un factor de potencia es un dispositivo formado por un conjunto de dielectrico y electrodos dentro de un recipiente con terminales, capaz de aportar capacitancia a un circuito electrico, como lo son: transformadores, motores de induccion, reguladores, aire acondicionado, maquinas soldadoras, hornos de induccion y balastros. Este documento tambien nos habla acerca de la localizacion de capacitores en su sistema, del conductor electrico, del recibo de consumo mensual de energia, de los beneficios al corregir factor de potencia, la liberacion de potencia del transformador, la reduccion de corriente en alimentadores, la reduccion de perdidas en alimentadores, la disminucion de la caida de tension y el precio de venta promedio aproximado.

  4. An??lisis de costos de las Instituciones Privadas de Ense??anza Superior del Estado de Amazonas: implicaciones para la Gesti??n Acad??mica = Cost Analysis of Private Institutions of Higher Education in the State of Amazonas: Implications for Academic Management

    OpenAIRE

    Reis Camelo, Mar??a dos

    2011-01-01

    342 p. Se considera la importancia de la dimensi??n econ??mica en la sociedad contempor??nea, y siendo la educaci??n un factor clave en el desarrollo de la econom??a de las naciones, el binomio econom??a y educaci??n es el tema central de este trabajo. Sus objetivos son analizar los costos de Instituciones de Educaci??n Superior (IES) y sus implicaciones en la gesti??n acad??mica, contrastar el potencial del mercado para la expansi??n de Ense??anza Superior en el Estado teni...

  5. El paleoceno de la alta cadena (subbetico interno, Cordillera Betica implicaciones en la evolución geodinamica del paleomargen sud-iberico

    Directory of Open Access Journals (Sweden)

    Martín-Martín, M.

    2002-08-01

    Full Text Available No formal formations have been defined taking into account the structural deformation and low quality of the Paleocene outcroppings open platform sediments from the High Chain area (Interna1 Subbetic, Málaga Province. Nevertheless, the better series are indicated, and a division in two depositional sequences are proposed: Lower Paleocene Depositional Sequence (SDPI and Upper Paleocene Depositional Sequence (SDPS, the later being sub-divided in two parasequences (P1 and P2 obtained from the clay mineralogy. The sequences have been defined on the basis of unconformity surfaces interpreted as due to tectonic or eustatic processes. It is proposed the geodynamic evolution of this materials belonging to the South-Iberian paleomargen according with stratigraphical, mineralogical and sedimentary analysis data and shows also the main characteristics of source areas during this period.La complejidad estructural de la región de la Alta Cadena (Subbético Interno de la Provincia de Málaga y la baja calidad de los afloramientos no ha permitido definir formalmente formaciones en los materiales paleocenos de plataforma abierta. No obstante, sí se indican los lugares de mejor exposición de las series, proponiendo una división en dos secuencias deposicionales: Secuencia Deposicional del Paleoceno Inferior (SDPI y Secuencia Deposicional del Paleoceno Superior (SDPS que, a su vez, queda dividida en dos parasecuencias (P1 y P2 obtenidas a partir del estudio mineralógico. Se definen estas secuencias a partir del reconocimiento de las superficies de discontinuidad que las delimitan, siendo éstas interpretadas como debidas a procesos tectónicos, en unos casos, o a procesos eustáticos, en otros. Se propone la evolución geodinámica de estos materiales mediante el estudio estratigráfico, mineralógico y análisis sedimentario. De forma complementaria se apuntan las principales características de sus áreas fuente durante este período.

  6. Implicaciones del acceso, uso y apropiación de las tic en la transformación de las relaciones sociales

    OpenAIRE

    Quintero Tangarife, Juan David; Robles Leal, David Andrés

    2013-01-01

    Tesis (Magister en Educación). Universidad Católica de Manizales, Facultad de Educación, 2012 Cuando se habla de estas tecnologías y sus redes se deben considerar la investigación, la innovación, el desarrollo científico, el avance en comunicación, el acercamiento de los diferentes entes sociales, los negocios y la vida del ser mismo, ya que todos estos se ven impactados por las llamadas TIC, al punto que algunos autores hablan de una sociedad de la información, Pierre Lévy por ejemplo se ...

  7. Evaluación de los sitios web de los hoteles e implicaciones para la gestión del marketing Hotelero

    OpenAIRE

    Schmidt, Serje

    2006-01-01

    En toda la historia del Marketing, no ha habido ninguna revolución tan impactante como la de Internet. Se comercializan en la Web productos cuya compra es basada en informaciones(productos fácilmente estandardizados), cuya distribución puede ser hecha por la Web, los que se puede añadir valor en relación a otras medias y, claro, aquellos productos cuyos clientes potenciales tienen acceso a la Internet; o sea, características típicas de la industria turística.Hoteles que hacia mucho tiempo com...

  8. Análisis Exploratorio Del Perfil Demandado Para Administración Y Dirección De Empresas: Implicaciones Para El Área Contable

    Directory of Open Access Journals (Sweden)

    José Luis Arquero-Montaño

    2009-07-01

    Los resultados determinan la importancia concedida por los egresados a los diferentes contenidos y habilidades que conforman el perfil profesional e indican el nivel de formación proporcionado en cada uno de ellos. A partir de estos resultados se identifican las actuaciones prioritarias. Respecto a los contenidos de contabilidad y finanzas, los principales resultados indican que los egresados consideran que son esenciales dentro del perfil, que son impartidos a un nivel adecuado y que no deberían reducir su peso en los nuevos planes de estudios.

  9. Técnicas psicoterapéuticas para proteger la confidencialidad y la responsabilidad legal: implicaciones del Biofeedback y Eeasp en el contexto jurídico

    Directory of Open Access Journals (Sweden)

    José Paulino Dzib Aguilar

    2010-01-01

    Full Text Available El Biofeedback a través del manejo de la temperatura periférica y la Escritura Emocional Autorreflexiva con Solución Propuesta (EEASP son técnicas psicoterapéuticas que dan respuesta a las discusiones éticas jurídicas sobre la confidencialidad. El objetivo de la investigación fue conocer si existen diferencias en la temperatura periférica. La muestra fue de 42 adultos con un promedio de edad de 32.9 años, siendo 32 hombres y 10 mujeres, 16 fueron estudiantes y 26 trabajadores, quienes reportaron estar sometidos a niveles elevados de estrés. Los resultados mostraron un aumento estadísticamente significativo (t = 6.35, p = 0.001 del promedio de la temperatura (89.68 °F. Los resultados confirman que el Biofeedback y la EEASP son técnicas que tienen un impacto positivo sobre los procesos psicofisiológicos de los participantes y que pueden ser usadas sin violar la confidencialidad así como exonerar de responsabilidades legales.

  10. Implicações anestésicas do tabagismo Implicaciones anestésicas del tabagismo Smoking and anesthetic implications

    Directory of Open Access Journals (Sweden)

    Ricardo Dorneles Furtado

    2002-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O fumo tem assumido grande importância em relação à morbidade anestésica. Apesar da divulgação acerca dos prejuízos à saúde, países reconhecidos como em desenvolvimento apresentam estatísticas crescentes quanto à população usuária de cigarros. O objetivo desta revisão é mostrar o modo de ação e efeitos do cigarro sobre os diversos órgãos e sistemas e seu impacto sobre a fisiologia do organismo, risco pré-operatório e o manuseio de pacientes fumantes durante a preparação pré-anestésica e complicações pós-operatórias. CONTEÚDO: Nesta revisão são apresentadas as diversas formas de ação do cigarro e seus componentes sobre órgãos e sistemas, repercussões orgânicas e a conduta anestésica para que haja redução da morbidade perioperatória nestes pacientes. CONCLUSÕES: A história do tabagismo na avaliação pré-anestésica deve ser enfaticamente valorizada e medidas preventivas em relação aos efeitos sistêmicos devem ser tomadas, minimizando assim os riscos dos procedimentos.JUSTIFICATIVA Y OBJETIVOS: El humo ha asumido grande importancia en relación a la morbidez anestésica. A pesar de la divulgación acerca de los prejuízos a la salud, países reconocidos como en desenvolvimiento presentan estadísticas crecientes cuanto a la población usuaria de cigarros. El objetivo de esta revisión es mostrar el modo de acción y efectos del cigarro sobre los diversos órganos y sistemas y el impacto de éstos sobre la fisiología del organismo, riesgo pré-operatorio y el manoseo de pacientes fumantes durante la preparación pré-anestésica y complicaciones pós-operatorias. CONTENIDO: En esta revisión son presentadas las diversas formas de acción del cigarro y sus componentes sobre órganos y sistemas, repercusiones orgánicas y la conducta anestésica para que haga reducción de la morbidad perioperatoria en estos pacientes. CONCLUSIONES: La historia del tabagismo en la evaluaci

  11. IMPLICACIONES DIDÁCTICAS EN LA TRADUCCIÓN ESPECIALIZADA: LOS ANGLICISMOS Y SU (NO TRADUCCIÓN EN EL ÁMBITO PROFESIONAL DEL DESARROLLO DE SOFTWARES

    Directory of Open Access Journals (Sweden)

    Elena Alcalde

    2013-08-01

    Full Text Available En este artículo, presentamos las necesidades denominativas en español que surgen debido a los nuevos productos o procesos relacionados con el desarrollo de softwares que se crean en la lengua inglesa mediante la utilización de la técnica del grupo de discusión entre expertos. Asimismo, analizamos las causas que llevan a los expertos a no utilizar un equivalente de los mismos en español y las consecuencias que tiene el uso de estos anglicismos para los traductores profesionales. Con base en las conclusiones, creemos necesario fomentar el trabajo en equipo desde los primeros niveles formativos para que los traductores combinen sus conocimientos lingüísticos con el conocimiento temático de los expertos y que juntos puedan reflexionar en la búsqueda de términos equivalentes en nuestra lengua.

  12. La dimensión económica de la pobreza y precariedad urbana en las ciudades latinoamericanas: Implicaciones para las políticas del habitat

    Directory of Open Access Journals (Sweden)

    LUCY WINCHESTER

    2008-12-01

    Full Text Available En las ciudades de América Latina y el Caribe, los pobres urbanos viven una heterogeneidad de condiciones y carencias que expresan directamente e indirectamente su vulnerabilidad económica. Este artículo busca profundizar nuestra comprensión de la dimensión económica de la pobreza y precariedad urbana en las vidas de los pobres urbanos, y averiguar sobre sus implicancias en el diseño de estrategias de política. El trabajo se basa en los enfoques conceptuales del desarrollo sostenible, y de la generación de capacidades y oportunidades en las personas. Se parte de una hipótesis de trabajo de que la vulnerabilidad económica en los sectores de pobreza urbana no ha sido plenamente integrada en las políticas del habitat, limitando la contribución de éstas a la mejora en el acceso de los pobres urbanos al empleo e ingresos estables.In Latin American and Caribbean cities, the urban poor are subject to diverse and heterogeneous living conditions that directly and indirectly reflect their economic vulnerability. This article seeks to deepen our understanding of the economic dimension of urban poverty and precarious living conditions in the lives of the urban poor, and to investigate their implications for public policy design. The work relies on the sustainable development framework and the policy discussions regarding capacity building and the creation of opportunities for the poor. Our working hypothesis is that an awareness of the economic vulnerability of the urban poor has not been fully integrated into urban policies, limiting their contribution to improving the poor's access to stable incomes and employment.

  13. Mapa de erosión de los suelos de México y posibles implicaciones en el almacenamiento de carbono orgánico del suelo

    Directory of Open Access Journals (Sweden)

    Martín A. Bolaños González

    2016-07-01

    Full Text Available Debido a la poca disponibilidad de información a nivel mundial y de manera acentuada en México del fenómeno de erosión de suelos; en este trabajo se presenta el Mapa Nacional de Erosión escala 1:50 000, el cual consolida un esfuerzo realizado por varios años en los que fue necesario conjuntar diversas fuentes de información para que mediante técnicas de fotointerpretación de imágenes de satélite de alta resolución, cartografía especializada e información de campo se concretara este producto, mismo que representa la información básica requerida para que, en el futuro, sea posible estimar de manera general las pérdidas de carbono orgánico del suelo debidas a éste fenómeno, dado que es uno de los componentes menos estudiados y, por consiguiente, menos cuantificados en el balance general de este elemento. Así, este primer resultado muestra que el 76% de la superficie nacional tiene algún grado de afectación por erosión hídrica, que corresponde a 6.79% con un grado de erosión extrema, el 5.79% fuerte, 26.37% moderada y 37.06% leve. Los estados más afectados por erosión apreciable (superficie relativa son: Distrito Federal, Tlaxcala, Estado de México y Michoacán y, por el contrario, los menos afectados: Tabasco, Quintana Roo y Campeche.

  14. Los yacimientos de vertebrados del Mioceno medio de Somosaguas (Pozuelo de Alarcón, Madrid: implicaciones paleoambientales y paleoclimáticas

    Directory of Open Access Journals (Sweden)

    López Martínez, N.

    2006-12-01

    Full Text Available The Middle Miocene vertebrate fossil sites from the Somosaguas Campus of the Complutensian University of Madrid (Pozuelo de Alarcón have provided many fossils from 23 mammal species, dated in local zone E (MN5, Middle Aragonian. In this work we show new research results which allow recognizing a new species of rhinoceros for the Madrid Basin (Prosantorhinus douvillei and defining a new species of hamster (Cricetodon soriae nov. sp.. The succession shows several episodes of debris-flow deposits transporting bones, pebbles and arkosic sands, discordant below and above lacustrine sediments. The deposits content an alteration sequence of micas, with neomorphic clays progressively more evolved and caliche lining on top, wich indicate increasing aridity. The richness of the Somosaguas fossil association allows us to relate this site with other assemblages of similar age, which gives a biogeographical pattern close to the palaearctic-palaeotropical transition associations. This is coincident with the palaeoclimatic data provided by the mammalian association, which indicates the presence of tropical conditions with strong hydric seasonality. A mosaic of environments integrated within a savanna biome is inferred in the area, combining open areas and small woodlands associated to a lacustrine environment. The isotopic analyses indicate a progressive cooling and drying trend, which correlates with the inferred global climatic changes in this period around 14 million years ago.Los yacimientos de vertebrados del Mioceno medio del Campus de Somosaguas de la Universidad Complutense de Madrid (Pozuelo de Alarcón han proporcionado numerosos restos pertenecientes a 23 especies de mamíferos datados en la zona local E (MN5, Aragoniense Medio. En este trabajo se presentan nuevas aportaciones a su estudio, que han permitido descubrir una especie de rinoceronte no citada anteriormente en la cuenca de Madrid (Prosantorhinus douvillei y la definición de una especie

  15. Clinical and ethical implications of genetic counselling in familial adenomatous polyposis Implicaciones clínicas y éticas del consejo genético en la poliposis adenomatosa familiar

    Directory of Open Access Journals (Sweden)

    A. Fernández-Suárez

    2005-09-01

    écnicas de secuenciación que detectan mutaciones en la línea germinal del gen APC (adenomatous poliposis coli. El abordaje del diagnóstico genético en familias con PAF seguidas previamente en la consulta de digestivo, ha permitido poner de manifiesto tanto las ventajas como los inconvenientes de esta forma de acercarnos a la enfermedad y a los pacientes. La revelación de los resultados de la prueba genética comporta importantes problemas en la práctica clínica, que afectan tanto al ámbito sanitario, como al ético y legal, además de las implicaciones familiares, laborales y sociales que el conocimiento del status genético puede tener para el paciente. El análisis genético es poco frecuente en la práctica clínica habitual, lo que conlleva errores tanto en la interpretación de los resultados obtenidos como durante el proceso del consejo genético. Son necesarias unidades multidisciplinares especializadas en el manejo de pacientes con PAF, en las cuales se realice un análisis y un consejo genético adecuado, permitiendo así una atención personalizada. La creación de registros de PAF y la protocolización de este proceso sanitario debería optimizar el manejo de estos pacientes y sus familias.

  16. Peso y talla en niños con retinoblastoma

    Directory of Open Access Journals (Sweden)

    Cecilia Ridaura-Sanz

    2015-03-01

    Full Text Available Introducción: la talla baja se ha descrito como característica clínica de niños con retinoblastoma. Esta particularidad puede estar relacionada directamente con la enfermedad de base o con factores externos.  Objetivo: el propósito de esta investigación fue conocer la frecuencia de talla y peso bajos en niños mexicanos con retinoblastoma y correlacionar los valores antropométricos con variables de la enfermedad y ambientales. Materiales y métodos: se analizaron expedientes clínicos de 346 pacientes con retinoblastoma. Se obtuvieron los datos de peso y talla referidos al ingreso; antes del tratamiento. Se comparó el valor de Z con las referencias de la distribución normal de la población mexicana. La asociación de las medidas antropométricas con las variables clínicas, sociales y genéticas se estableció con la prueba de c2. Resultados: la talla y el peso promedio de los niños con retinoblastoma fueron significativamente más bajos que los de la población general (p < 0.001 y p = 0.013, respectivamente. La talla y peso bajos fueron más frecuentes en niños con enfermedad avanzada, provenientes de medio rural y de bajo nivel socioeconómico. Conclusiones: los déficits en peso y talla en niños con retinoblastoma se deben a factores relacionados con enfermedad avanzada al momento del diagnóstico, lo cual a su vez es consecuencia de la situación de marginación de la población rural mexicana. Dado que la mayoría de las variables sociales y ambientales están muy relacionadas y que no podemos descartar posibles factores genéticos, las conclusiones de este estudio deben verificarse analizando las medidas de los padres y hermanos y establecer grupos comparativos para controlar las variables confusas.

  17. Dificultades del alumnado con déficit de atención con hiperactividad (TD?? en el aula: implicaciones para la formación docente

    Directory of Open Access Journals (Sweden)

    Francisco D. FERNÁNDEZ MARTÍN

    2009-11-01

    Full Text Available RESUMEN: El propósito del estudio fue determinar el impacto de una intervención cognitivo-conductual sobre una muestra de alumnos diagnosticados con TDAH pertenecientes a diversos centros de enseñanza de Educación Primaria de la provincia de Granada. Para llevar a cabo el estudio, se utilizaron diversas pruebas con las que se evaluó el control inhibitorio, el control perceptivomotor, la memoria y la atención, considerados/ as como los/as manifestaciones más comunes del TDAH, en el contexto escolar. La intervención se basó en la formación de padres y docentes, así como en un posterior entrenamiento específico y directo sobre el alumnado. Los resultados post de la intervención, manifiestan que se han producido mejoras significativas en las conductas problema que presentaban los alumnos en el contexto escolar.ABSTRACT: The purpose of this study was to determine the impact of a cognitive-behavioural intervention among a sample of students diagnosed with ADHD, belonging to several Primary Education Schools within the province of Granada. In order to carry out this research several evaluation test were administered to evaluate inhibitory control, motor-perceptive control, memory and attention, considered those as the more frequent features of ADHD, within the school settings. The intervention consisted of providing training teachers. The Post intervention results show that significant improvement where reached by students at school settings.RÉSUMÉ: L'intention de l'étude c'était déterminer l'impact d'une intervention cognitive-conductuel sur une échantillon d'élèves diagnostiqués avec TDAH, appartenant à divers centres d'enseignement d'Éducation Primaire de la province de Granada. Pour réaliser l'étude, on a utilisé des divers preuves avec les quelles on a évalué le contrôle inhibitoire, le contrôle perceptive-moteur, la mémoire et l'attention considérés comme les manifestations les plus communes du TDAH, dans le

  18. Análisis Exploratorio del Perfil Demandado para Administración y Dirección de Empresas: Implicaciones para el Área Contable

    Directory of Open Access Journals (Sweden)

    José Luis Arquero Montaño

    2009-12-01

    Full Text Available La inserción de España en el Espacio Europeo de Educación Superior desembocará en una modificación de la estructura, duración y contenido de las titulaciones. Estas modificaciones no deben entenderse como un acontecimiento aislado, sino como una secuencia más en el debate sobre la calidad de los títulos universitarios. El objetivo del trabajo es identificar las necesidades de formación percibidas por los egresados de Administración y Dirección de Empresas de la Universidad de Sevilla, profundizando en los contenidos de contabilidad. Los resultados pueden constituir un referente para otras universidades españolas, de características similares, que se encuentran actualmente rediseñando sus planes de estudio, proporcionándoles información útil al respecto. Para ello, el trabajo emplea un enfoque multimetodológico en varias etapas que incluye como principales fuentes de información el cuestionario cerrado y las entrevistas de profundización y ampliación.Los resultados determinan la importancia concedida por los egresados a los diferentes contenidos y habilidades que conforman el perfil profesional e indican el nivel de formación proporcionado en cada uno de ellos. A partir de estos resultados se identifican las actuaciones prioritarias. Respecto a los contenidos de contabilidad y finanzas, los principales resultados indican que los egresados consideran que son esenciales dentro del perfil, que son impartidos a un nivel adecuado y que no deberían reducir su peso en los nuevos planes de estudios.The Bologna process in Spain will imply a modification in the syllabuses structure and programmes length of the present degrees. In our opinion this modifications are not isolated events, but part of a sequence in the debate on higher education quality. In higher education that implies the adjustment of the degrees to the demanded professional profiles.The present paper aims to analyse the educational needs perceived by business

  19. Estabilidad temporal del C.I. y potencial de aprendizaje en niños superdotados: implicaciones diagnósticas

    Directory of Open Access Journals (Sweden)

    Mª Dolores Calero

    2014-05-01

    Full Text Available Tradicionalmente la determinación de la sobredotación se ha realizado con tests tradicionales de inteligencia. El principal argumento para hacerlo ha sido la estabilidad temporal de esta medida. En los últimos años algunos autores defienden una determinación temprana de la sobredotación en niños, aunque otros señalan que la determinación del C.I. en niños pequeños arroja un número importante de falsos positivos debido a la variabilidad de la medida de la inteligencia por influencia de diferentes factores tales como la plasticidad cerebral, la estimulación, etc., por lo que proponen el uso de índices complementarios para el diagnóstico de sobredotación. En este trabajo se realiza un estudio longitudinal de dos años a 49 niños de entre 5 y 9 años, -inicialmente identificados como superdotados-, para comprobar la estabilidad de su C.I. y de otras medidas tales como el potencial de aprendizaje y la memoria de trabajo. Los resultados muestran como las medidas de potencial de aprendizaje y memoria de trabajo permanecen estables en el tiempo mientras que el C.I. de un grupo de niños de menor edad no se mantiene en dicho periodo. Estos resultados señalan la utilidad de las medidas de P.A. como un índice complementario en la determinación de la sobredotación en niños pequeños.

  20. Humanización de la Sanidad y Salud Laboral: Implicaciones, estado de la cuestión y propuesta del Proyecto HU-CI

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    Macarena Gálvez Herrer

    Full Text Available Resumen La evolución científica y técnica de la atención sanitaria mantienen un desarrollo exponencial que permite cada vez una mejor asistencia a los pacientes, nuevas formas de tratamiento y crecientes índices de supervivencia. Sin embargo, estos importantes avances que enriquecen la atención a la salud, en muchas ocasiones, han ido invadiendo espacio al propio acto humano de la atención a la persona. Potenciar organizaciones más humanizadas implicará establecer acciones dirigidas al ambiente y lugar de trabajo, así como a todos los agentes implicados (pacientes, familiares y profesionales. Con dicha finalidad, las políticas de Humanización y su aplicación al contexto sanitario son una realidad en nuestros días y están concretándose en algunas propuestas específicas en determinadas organizaciones, con el apoyo de algunos organismos oficiales. En el presente trabajo, señalamos la interacción entre los objetivos de dichas políticas de humanización y las metas de la salud laboral en contextos asistenciales. Se exploran áreas comunes de trabajo dirigidas al bienestar del profesional sanitario, posibilidades de gestión integral de ambos conceptos, y se expone un ejemplo concreto como es el Proyecto de Humanización de las Unidades de Cuidados Intensivos (HU-CI.

  1. Inhibition of Retinoblastoma Protein Inactivation

    Science.gov (United States)

    2017-11-01

    CONTRACT NUMBER Inhibition of Retinoblastoma Protein Inactivation 5b. GRANT NUMBER W81XWH-14-1-0329 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Seth M...confirmed 108 compounds as giving a dose-response curve with at least 30% inhibition at 10 µM. The flowchart of hit progression is shown on the...Cancer Research Program under Award No. W81XWH-14-1-0329 to S.M.R. Opinions, interpretations, conclusions, and recommendations are those of the author

  2. Información sobre las secuelas y futuros riesgos para los sobrevivientes de retinoblastoma Information on late effects and future risks for retinoblastoma survivors

    Directory of Open Access Journals (Sweden)

    Laura Schwartz

    2005-04-01

    Full Text Available Los índices de sobrevida de los pacientes con cáncer en la infancia han aumentado en las últimas décadas. Se observan secuelas como consecuencia de esta enfermedad y su tratamiento. Los sobrevivientes de retinoblastoma presentan efectos adversos como consecuencia de la cirugía, la radioterapia y la quimioterapia. Las formas bilaterales irradiadas presentan un riesgo aumentado de desarrollar un segundo cáncer. Tanto los casos que presentaron retinoblastoma unilateral o bilateral pueden transmitir esta enfermedad a su descendencia. El diagnóstico de este tumor es excepcional después de los 4 años de edad y no se sabe claramente qué conocimiento tienen estos sobrevivientes del diagnóstico, del tratamiento y de los futuros riesgos. El consentimiento informado y el posterior resumen de historia clínica no aclaran demasiado a los padres. Los pacientes curados de retinoblastoma se verían beneficiados con un seguimiento prolongado en las instituciones en que fueron tratados, ya que les permitiría recibir información acerca de lo padecido, del tratamiento, de los riesgos y se podrían identificar las consecuencias posteriores de la enfermedad y su tratamiento.The survival rates of childhood cancer have increased in the past few decades. Late consequences related to the cancer and the treatment are observed. The late effects in retinoblastoma survivors are related to the surgery, the radiotherapy and the chemotherapy. Patients with irradiated bilateral retinoblastoma are at high risk to develop a second cancer. Survivors of bilateral or unilateral forms could transmit this disease to their offspring. The diagnosis of retinoblastoma is exceptional after 4 years of age, and it is not clear whether these survivors have knowledge of their diagnosis, treatment and future risks. The informed consent and the summary of the clinical histories do not help to clarify the situation. It will be of great benefit for the patients cured of retinoblastoma

  3. Implicaciones de las nanotecnologías en el empleo

    Directory of Open Access Journals (Sweden)

    Noela Invernizzi

    2016-02-01

    Full Text Available Las investigaciones sobre las implicaciones sociales de las nanotecnologías no han abordado el tema del empleo, a pesar de su importancia social. A partir del análisis de las características de los productos de la nanotecnología que están en el mercado, este artículo muestra que las nanotecnologías tendrán un impacto considerable en la distribución del empleo entre los sectores, en la división internacional del trabajo y en las calificaciones para las actividades, causando efectos desestabilizadores en el empleo a nivel nacional y global.

  4. Late onset retinoblastoma presenting with vitreous haemorrhage

    DEFF Research Database (Denmark)

    Bagger, Mette; Prause, Jan Ulrik; Heegard, Steffen

    2012-01-01

    in the retina. A vascularized gelatinous mass was revealed after vitrectomy. Later the patient developed white cysts in the anterior chamber and histological findings were indicative of a retinoblastoma. The patient was enucleated and the diagnosis of retinoblastoma was confirmed. Intraocular surgery in young...... people with unknown retinoblastoma enhances the risk of metastasis development, orbital recurrence and death. Unexplained vitreous haemorrhage can obscure the view of a tumour but ultrasonic findings of a retinal mass calls for further imaging e.g. through MRI. The case illustrates the importance...

  5. [Familial retinoblastoma: cytogenetic study of the tumor].

    Science.gov (United States)

    Robledo Batanero, M; Manzanal Martínez, A; Ayuso García, C; Benítez Ortiz, J

    1990-05-01

    We report a case of familiar retinoblastoma, in which both mother and daughter show bilateral retinoblastoma. The cytogenetic study, in both peripheral blood lymphocytes and tumoral tissue did not show alterations on the 13 chromosome, although we found a complex kariotype in tumoral tissue defined by three celular lines. In all of them appears a marker in which the 6 chromosome is involved (der 6). The derivated of 6 chromosome are markers highly characteristic of the retinoblastoma cases, and can be related with the aggressivity of tumor and the appearance of the second tumors.

  6. La naturaleza de la disputa entre el Norte y el Sur y las implicaciones del Tratado General de Paz para el proceso de formación de Sudán del Sur

    OpenAIRE

    Silva de Freitas, Jeane; Loyolla Kuhlmann, Paulo Roberto

    2015-01-01

    Este artículo tiene como objetivo analizar el proceso de formación de la República del Sudán del Sur y la implementación del Tratado General de Paz (CPA) en el ámbito de los factores que influenciaron la evolución del conflicto sudanés. Por lo tanto, el objetivo es resaltar la relevancia y las consecuencias de la implementación del CPA para los dos Estados Sudaneses a partir de algunas interrogantes: ¿Por qué este tratado fue pactado? ¿Qué objetivos esperaban alcanzar y por qué se...

  7. Clinicopathological pattern and management of retinoblastoma in ...

    African Journals Online (AJOL)

    shobha

    leucocoria, proptosis, hyphaema without history of trauma, unexplained ... Conclusion: Retinoblastoma, a treatable tumor is characterized by late presentation as illustrated in our ..... Great Britain 1969-80: Incidence, treatment and survival.

  8. Immunohistochemical demonstration of glial markers in retinoblastomas

    DEFF Research Database (Denmark)

    Schrøder, H D

    1987-01-01

    Twenty retinoblastomas were studied immunohistochemically in order to visualize glial cells. In the retina, the glial cells in the ganglion cell layer and the Müller cells were GFAP positive, while only the glial cells of the ganglion cell layer expressed S-100 reactivity. In the tumours S-100/GFAP...... cells reactive for both S-100 and GFAP were demonstrated. The latter findings may represent differentiation in a glial direction in the more mature parts of retinoblastoma....

  9. Retinoblastoma

    Science.gov (United States)

    ... Feb 20, 2018 Gene Therapy May Be a Game-Changer for People With Inherited Retinal Disease Dec 19, 2017 ... the Academy Jobs at the Academy Financial Relationships with Industry Medical Disclaimer Privacy Policy Terms of Service For ...

  10. Retinoblastoma

    Science.gov (United States)

    ... NEI Intranet (Employees Only) *PDF files require the free Adobe® Reader® software for viewing. This website is maintained by the NEI Office of Science Communications, Public Liaison, and Education. Technical questions about this website can be addressed ...

  11. El clima de la vertiente del Pacífico de los Andes Centrales y sus implicaciones geomorfológicas El clima de la vertiente del Pacífico de los Andes Centrales y sus implicaciones geomorfológicas

    Directory of Open Access Journals (Sweden)

    Jose Úbeda Palenque

    2008-12-01

    Full Text Available Climate studies are of main importance to explain the external geodynamics of the Pacific Basin of the Central Andes between 15°S and 19°S. This is because the processes by which the relief modeling or morphogenesis develop are controlled by pluviometric variables and phyto stabilization. Moreover, the internal geodynamic of the region is related to the climatic conditions that determine the amounts of sediments aported to the Ocean basin (Kulm et al. 1977, affecting the erosion rate by subduction in the plane of contact between the tectonic plates and the composition of the magazas formed below the Andean erogene.In this paper we analyze the climatic effects in the external geodynamics, within a theoric framework that considers a morphoclimatic system as a set formed by the morphogenetic agents and processes that work the relief modeling in a territory, in function of its bioclimatic characteristics; and a morphoclimatic dominion is the spatial environment where a specific morphoclimatic system develops.First, we present the clima of the Central Andes, the factors that control its mean configuration and its main characteristics with diagrams made from the pluviometric data collected in a series of stations regularly distributed in the region. Second, we differentiate two climatic dominions, one in the Altiplano, related to Amazonia precipitations and the other at the Pacific side, associated to the anticyclonic permanency in the western cordillera. Third, we propose a subdivision of the western façade of the cordillera in altitudinal intervals or bioclimatics sections using bioindicators such as the vegetation absence or presence with altitudinal change. Fourth, we give a new division in altitudinal intervals or morphoclimatic zones, using the existence of some geoindicators, such as the endemic geomorphic units of each morphoclimatic zone.El estudio del clima es imprescindible para explicar la geodinámica externa en la vertiente del Pac

  12. Retinoblastoma: genetic considerations and report of a new animal model

    NARCIS (Netherlands)

    Albert, D.M.; O'Brien, J.M.; Marcus, D.M.; Bernards, R.A.

    1990-01-01

    Retinoblastoma is the most common primary, intraocular neoplasm of childhood. Histologically, retinoblastoma resembles, in many respects, other pediatric malignancies such as medulloblastoma and neuroblastoma. These tumors are composed of small, basophilic cells with scanty cytoplasm and often

  13. IMPLICACIONES BIOÉTICAS DERIVADAS DEL ACCESO DE LAS PAREJAS DEL MISMO SEXO A LAS TECNOLOGÍAS PROVENIENTES DE LA BIOMEDICINA Y LA BIOTECNOLOGÍA, PARA LA CONFORMACIÓN DE FAMILIAS HOMOPARENTALES

    OpenAIRE

    Zárate-Cuello, Amparo de Jesús; Celis, Luis Gustavo

    2015-01-01

    En este artículo se realiza una reflexión y una revisión, desde el ámbito de las ciencias básicas y del bioderecho, sobre los aspectos biológicos y genéticos de la homosexualidad, y sobre el impacto que tiene en la familia el acceso a las técnicas de reproducción asistida por parte de las parejas del mismo sexo. Lo anterior nos lleva al desarrollo de conceptos como la "violencia prenatal", el derecho de los niños a crecer en el seno de una familia con una imagen paterna y materna, al igual qu...

  14. Creando subjetividades laborales: implicaciones del discurso psicológico en el mundo del trabajo y las organizaciones Criando subjetividades do trabalho: implicações do discurso psicológico no mundo do trabalho e as organizações Creating work subjectivities: implications of the psychological discourse in the world of work and organizations

    Directory of Open Access Journals (Sweden)

    Verónica Andrade

    2013-01-01

    Full Text Available El presente documento tiene como propósito explorar aportes de la psicología crítica al entendimiento de las dinámicas que se mueven en el mundo del trabajo y las organizaciones, y algunas críticas que esta aporta a la psicología organizacional y del trabajo moderna. Para tal fin, se plantean algunos elementos conceptuales de base para clarificar la acepción al respecto del concepto subjetividad y las implicaciones de la psicología crítica; igualmente se exponen algunas reflexiones que explicitan las formas en que el discurso psicológico -reflejado además en prácticas- está embebido en el mundo del trabajo y las organizaciones, y que en gran medida contribuye a construir las subjetividades de personas que trabajan, y las relaciones que se establecen al interior de las organizaciones de trabajo.O objetivo do presente documento é analisar as contribuições da psicologia crítica ao entendimento das dinâmicas envolvidas no mundo do trabalho e das organizações, assim como algumas críticas que tal ramo da psicologia fornece à psicologia organizacional e do trabalho moderno. Para tal fim, alguns elementos conceituais de base são propostos para esclarecer a acepção a respeito do conceito de subjetividade e as implicações da psicologia crítica; igualmente apresentam-se algumas reflexões que explicitam os modos como o discurso psicológico - representado ademais nas diferentes práticas - está embutido no mundo do trabalho e das organizações, e que, em grande medida, contribui à construção das subjetividades de pessoas que trabalham, assim como as relações que se estabelecem no interior das organizações de trabalho.This paper aims to explore contributions of critical psychology for the understanding of the dynamics that take place in the world of work and organizations, and some reviews that this psychology makes to the organizational psychology and modern work. To this end, some basic conceptual elements are proposed

  15. EL TRIBUNAL DEL JURADO EN ESTADOS UNIDOS, FRANCIA Y ESPAÑA: TRES MODELOS DE PARTICIPACIÓN EN LA ADMINISTRACIÓN DE JUSTICIA. IMPLICACIONES PARA LA EDUCACIÓN DEL CIUDADANO

    Directory of Open Access Journals (Sweden)

    Mercedes Novo Pérez

    2002-07-01

    Full Text Available En el presente trabajo, desde el marco integrador de la Psicología Jurídica, planteamos una revisión histórica de la institución del Tribunal del Jurado desde sus antecedentes remotos hasta la regulación actual reflejada en tres arquetipos: el modelo estadounidense, el modelo francés y el modelo español. Además destacamos algunos hallazgos de la Psicología Jurídica que arrojan luz sobre el funcionamiento de la institución. Asimismo, reflexionamos sobre la situación actual en nuestro ordenamiento jurídico valorando, desde una óptica de propuestas de mejora, algunos puntos débiles en su funcionamiento. En este sentido, apelamos al rol de la educación institucionalizada, como medio privilegiado de culturización del ciudadano y de formación en valores relacionados con la justicia. La escuela se nos antoja como un canal de transmisión de valores y de formación de actitudes.

  16. Crecimiento, acumulación y empleo en una economia con tasa de inflación constante: implicaciones de política económica

    OpenAIRE

    Luis Alberto Alonso González; Jorge Uxó González

    1995-01-01

    Análisis teórico del problema del desempleo elevado y persistente que caracteriza a la mayoría de las economías europeas. Se hace un enfoque dinámico, y al final del artículo se extraen las implicaciones de política económica más relevantes.

  17. Seguridad en el mar, algunas implicaciones de los códigos IGS y PBIB.

    OpenAIRE

    José Vicente Guzmán Escobar

    2007-01-01

    La expedición del Código Internacional de Gestión de la Seguridad Marítima (Código IGS) y del Código de Protección de Buques e Instalaciones Portuarias (Código PBIB), en el contexto del Convenio SOLAS, tiene especiales implicaciones legales en diferentes figuras del derecho marítimo internacional, tales como la limitación de responsabilidad de los armadores de buques por reclamaciones marítimas, la limitación de responsabilidad de los armadores por contaminación por derrames de hidrocarburos,...

  18. Transcriptional inhibition by the retinoblastoma protein

    DEFF Research Database (Denmark)

    Fattaey, A; Helin, K; Harlow, E

    1993-01-01

    The retinoblastoma protein, pRB, appears to play a key role in coordinating the regulation of cell cycle position and transcriptional events. pRB undergoes specific cell-cycle-dependent phosphorylation, being underphosphorylated in G1 and heavily phosphorylated in S, G2, and M. The underphosphory......The retinoblastoma protein, pRB, appears to play a key role in coordinating the regulation of cell cycle position and transcriptional events. pRB undergoes specific cell-cycle-dependent phosphorylation, being underphosphorylated in G1 and heavily phosphorylated in S, G2, and M......-mediated transcription would be lost by mutation in the retinoblastoma gene in human tumours, by pRB's interaction with DNA tumour virus oncoproteins, or by phosphorylation during the cell cycle....

  19. Intensity modulated radiotherapy (IMRT) in bilateral retinoblastoma

    International Nuclear Information System (INIS)

    Atalar, Banu; Ozyar, Enis; Gunduz, Kaan; Gungor, Gorkem

    2010-01-01

    External beam radiotherapy (EBRT) for retinoblastoma has traditionally been done with conventional radiotherapy techniques which resulted high doses to the surrounding normal tissues. A 20 month-old girl with group D bilateral retinoblastoma underwent intensity modulated radiotherapy (IMRT) to both eyes after failing chemoreduction and focal therapies including cryotherapy and transpupillary thermotherapy. In this report, we discuss the use of IMRT as a method for reducing doses to adjacent normal tissues while delivering therapeutic doses to the tumour tissues compared with 3-dimensional conformal radiotherapy (3DCRT). At one year follow-up, the patient remained free of any obvious radiation complications. Image guided IMRT provides better dose distribution than 3DCRT in retinoblastoma eyes, delivering the therapeutic dose to the tumours and minimizing adjacent tissue damage

  20. Tumor regression patterns in retinoblastoma

    International Nuclear Information System (INIS)

    Zafar, S.N.; Siddique, S.N.; Zaheer, N.

    2016-01-01

    To observe the types of tumor regression after treatment, and identify the common pattern of regression in our patients. Study Design: Descriptive study. Place and Duration of Study: Department of Pediatric Ophthalmology and Strabismus, Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan, from October 2011 to October 2014. Methodology: Children with unilateral and bilateral retinoblastoma were included in the study. Patients were referred to Pakistan Institute of Medical Sciences, Islamabad, for chemotherapy. After every cycle of chemotherapy, dilated funds examination under anesthesia was performed to record response of the treatment. Regression patterns were recorded on RetCam II. Results: Seventy-four tumors were included in the study. Out of 74 tumors, 3 were ICRB group A tumors, 43 were ICRB group B tumors, 14 tumors belonged to ICRB group C, and remaining 14 were ICRB group D tumors. Type IV regression was seen in 39.1% (n=29) tumors, type II in 29.7% (n=22), type III in 25.6% (n=19), and type I in 5.4% (n=4). All group A tumors (100%) showed type IV regression. Seventeen (39.5%) group B tumors showed type IV regression. In group C, 5 tumors (35.7%) showed type II regression and 5 tumors (35.7%) showed type IV regression. In group D, 6 tumors (42.9%) regressed to type II non-calcified remnants. Conclusion: The response and success of the focal and systemic treatment, as judged by the appearance of different patterns of tumor regression, varies with the ICRB grouping of the tumor. (author)

  1. The retinoblastoma protein as a transcriptional repressor

    DEFF Research Database (Denmark)

    Helin, K; Ed, H

    1993-01-01

    The retinoblastoma protein (pRB) is one of the best-studied tumour suppressor gene products. Its loss during the genesis of many human tumours, its inactivation by several DNA tumour virus oncoproteins, and its ability to inhibit cell growth when introduced into dividing cells all suggest that p...

  2. Expression of multidrug resistance proteins in retinoblastoma

    Directory of Open Access Journals (Sweden)

    Swati Shukla

    2017-11-01

    Full Text Available AIM: To elucidate the mechanism of multidrug resistance in retinoblastoma, and to acquire more insights into in vivo drug resistance. METHODS: Three anticancer drug resistant Y79 human RB cells were generated against vincristine, etoposide or carboplatin, which are used for conventional chemotherapy in RB. Primary cultures from enucleated eyes after chemotherapy (PCNC were also prepared. Their chemosensitivity to chemotherapeutic agents (vincristine, etoposide and carboplatin were measured using MTT assay. Western blot analysis was performed to evaluate the expression of p53, Bcl-2 and various multidrug resistant proteins in retinoblastoma cells. RESULTS: Following exposure to chemotherapeutic drugs, PCNC showed less sensitivity to drugs. No significant changes observed in the p53 expression, whereas Bcl-2 expression was found to be increased in the drug resistant cells as well as in PCNC. Increased expression of P-glycoprotein (P-gp was observed in drug resistant Y79 cells; however there was no significant change in the expression of P-gp found between primary cultures of primarily enucleated eyes and PCNC. Multidrug resistance protein 1 (Mrp-1 expression was found to be elevated in the drug resistant Y79 cells as well as in PCNC. No significant change in the expression of lung resistance associated protein (Lrp was observed in the drug resistant Y79 cells as well as in PCNC. CONCLUSION: Our results suggest that multidrug resistant proteins are intrinsically present in retinoblastoma which causes treatment failure in managing retinoblastoma with chemotherapy.

  3. Expression of multidrug resistance proteins in retinoblastoma.

    Science.gov (United States)

    Shukla, Swati; Srivastava, Arpna; Kumar, Sunil; Singh, Usha; Goswami, Sandeep; Chawla, Bhavna; Bajaj, Mandeep Singh; Kashyap, Seema; Kaur, Jasbir

    2017-01-01

    To elucidate the mechanism of multidrug resistance in retinoblastoma, and to acquire more insights into in vivo drug resistance. Three anticancer drug resistant Y79 human RB cells were generated against vincristine, etoposide or carboplatin, which are used for conventional chemotherapy in RB. Primary cultures from enucleated eyes after chemotherapy (PCNC) were also prepared. Their chemosensitivity to chemotherapeutic agents (vincristine, etoposide and carboplatin) were measured using MTT assay. Western blot analysis was performed to evaluate the expression of p53, Bcl-2 and various multidrug resistant proteins in retinoblastoma cells. Following exposure to chemotherapeutic drugs, PCNC showed less sensitivity to drugs. No significant changes observed in the p53 expression, whereas Bcl-2 expression was found to be increased in the drug resistant cells as well as in PCNC. Increased expression of P-glycoprotein (P-gp) was observed in drug resistant Y79 cells; however there was no significant change in the expression of P-gp found between primary cultures of primarily enucleated eyes and PCNC. Multidrug resistance protein 1 (Mrp-1) expression was found to be elevated in the drug resistant Y79 cells as well as in PCNC. No significant change in the expression of lung resistance associated protein (Lrp) was observed in the drug resistant Y79 cells as well as in PCNC. Our results suggest that multidrug resistant proteins are intrinsically present in retinoblastoma which causes treatment failure in managing retinoblastoma with chemotherapy.

  4. Expression of multidrug resistance proteins in retinoblastoma

    Science.gov (United States)

    Shukla, Swati; Srivastava, Arpna; Kumar, Sunil; Singh, Usha; Goswami, Sandeep; Chawla, Bhavna; Bajaj, Mandeep Singh; Kashyap, Seema; Kaur, Jasbir

    2017-01-01

    AIM To elucidate the mechanism of multidrug resistance in retinoblastoma, and to acquire more insights into in vivo drug resistance. METHODS Three anticancer drug resistant Y79 human RB cells were generated against vincristine, etoposide or carboplatin, which are used for conventional chemotherapy in RB. Primary cultures from enucleated eyes after chemotherapy (PCNC) were also prepared. Their chemosensitivity to chemotherapeutic agents (vincristine, etoposide and carboplatin) were measured using MTT assay. Western blot analysis was performed to evaluate the expression of p53, Bcl-2 and various multidrug resistant proteins in retinoblastoma cells. RESULTS Following exposure to chemotherapeutic drugs, PCNC showed less sensitivity to drugs. No significant changes observed in the p53 expression, whereas Bcl-2 expression was found to be increased in the drug resistant cells as well as in PCNC. Increased expression of P-glycoprotein (P-gp) was observed in drug resistant Y79 cells; however there was no significant change in the expression of P-gp found between primary cultures of primarily enucleated eyes and PCNC. Multidrug resistance protein 1 (Mrp-1) expression was found to be elevated in the drug resistant Y79 cells as well as in PCNC. No significant change in the expression of lung resistance associated protein (Lrp) was observed in the drug resistant Y79 cells as well as in PCNC. CONCLUSION Our results suggest that multidrug resistant proteins are intrinsically present in retinoblastoma which causes treatment failure in managing retinoblastoma with chemotherapy. PMID:29181307

  5. Retinoblastoma: genetics, diagnosis, treatment and sequelae

    International Nuclear Information System (INIS)

    Halperin, Edward C.

    1995-01-01

    There has been a conceptual breakthrough in our understanding of the molecular and genetic basis of the origins of human neoplasia. Mutations in three broad categories of genes have been shown to contribute to the origins and progression of neoplasia in humans: the oncogenes, the tumor suppressor genes, and the mutator genes. The retinoblastoma gene (RB1) is the best characterized tumor suppressor gene. It was first localized by Knudson and coworkers who observed an association between a deletion on the long arm of chromosome 13 and an inherited predisposition to retinoblastoma. The RB1 gene is composed of 27 exons encompassing more than 200 kilobases of genomic DNA. The product of the RB1 gene is a 105-107 kDa nuclear phosphoprotein which plays a part in regulating cellular DNA synthesis. Tumors arise, as predicted by Knudson's 'two-hit' hypothesis, as a result of bi-allelic mutation of the RB1 gene. Inactivating mutations of the RB1 gene have been identified in various tumors, showing the RB1 gene product has an important role in regulating cell proliferation beyond its effect on retinoblasts. The RB1 gene was cloned and identified in 1986. Returning the RB1 gene to a retinoblastoma cell in culture reduces its tumorgenic potential. Retinoblastoma is the most common malignant intraocular tumor of childhood. The tumor consists of undifferentiated small anaplastic cells which may be round or polygonal. Both Flexner and Wintersteiner described the arrangement of the more differentiated malignant retinoblastoma cells in neuroepithelial rosettes which appear to represent an attempt to differentiate into photoreceptor cells. The tumor commonly presents with a white pupillary light reflex. The diagnosis is generally made based on physical examination, confirmatory photographs and diagnostic imaging studies and, in many cases, a supportive family history. The most widely used grouping system was proposed by Algernon Reese and Robert Ellsworth. The primary goal of

  6. Retinoblastoma: Genetics, diagnosis, treatment and sequelae

    International Nuclear Information System (INIS)

    Halperin, Edward C.

    1996-01-01

    There has been a conceptual breakthrough in our understanding of the molecular and genetic basis of the origins of human neoplasia. Mutations in three broad categories of genes have been shown to contribute to the origins and progression of neoplasia in humans: the oncogenes, the tumor suppressor genes, and the mutator genes. The retinoblastoma gene (RB1) is the best characterized tumor suppressor gene. It was first localized by Knudson and coworkers who observed an association between a deletion on the long arm of chromosome 13 and an inherited predisposition to retinoblastoma. The RB1 gene is composed of 27 exons encompassing more than 200 kilobases of genomic DNA. The product of the RB1 gene is a 105-107 kDa nuclear phosphoprotein which plays a part in regulating cellular DNA synthesis. Tumors arise, as predicted by Knudson's 'two-hit' hypothesis, as a result of biallelic mutation of the RB1 gene. Inactivating mutations of the RB1 gene have been identified in various tumors, showing the RB1 gene product has an important role in regulating cell proliferation beyond its effect on retinoblasts. The RB1 gene was cloned and identified in 1986. Returning the RB1 gene to a retinoblastoma cell in culture reduces its tumorgenic potential. Retinoblastoma is the most common malignant intraocular tumor of childhood. The tumor consists of undifferentiated small anaplastic cells which may be round or polygonal. Both Flexner and Wintersteiner described the arrangement of the more differentiated malignant retinoblastoma cells in neuroepithelial rosettes which appear to represent an attempt to differentiate into photoreceptor cells. The tumor commonly presents with a white pupillary light reflex. The diagnosis is generally made based on physical examination, confirmatory photographs and diagnostic imaging studies and, in many cases, a supportive family history. The most widely used grouping system was proposed by Algernon Reese and Robert Ellsworth. The primary goal of

  7. Guidelines for imaging retinoblastoma: imaging principles and MRI standardization

    Energy Technology Data Exchange (ETDEWEB)

    Graaf, Pim de; Rodjan, Firazia; Castelijns, Jonas A. [VU University Medical Center, Department of Radiology, Amsterdam (Netherlands); Goericke, Sophia [University Hospital, Department of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); Galluzzi, Paolo [Azienda Ospedaliera e Universitaria Senese, Policlinico ' ' Le Scotte' ' , Unit of Diagnostic and Therapeutic Neuroradiology, Siena (Italy); Maeder, Philippe [CHUV, Service de Radiodiagnostic et Radiologie Interventionelle, Lausanne (Switzerland); Brisse, Herve J. [Institut Curie, Departement d' Imagerie, Paris (France)

    2012-01-15

    Retinoblastoma is the most common intraocular tumor in children. The diagnosis is usually established by the ophthalmologist on the basis of fundoscopy and US. Together with US, high-resolution MRI has emerged as an important imaging modality for pretreatment assessment, i.e. for diagnostic confirmation, detection of local tumor extent, detection of associated developmental malformation of the brain and detection of associated intracranial primitive neuroectodermal tumor (trilateral retinoblastoma). Minimum requirements for pretreatment diagnostic evaluation of retinoblastoma or mimicking lesions are presented, based on consensus among members of the European Retinoblastoma Imaging Collaboration (ERIC). The most appropriate techniques for imaging in a child with leukocoria are reviewed. CT is no longer recommended. Implementation of a standardized MRI protocol for retinoblastoma in clinical practice may benefit children worldwide, especially those with hereditary retinoblastoma, since a decreased use of CT reduces the exposure to ionizing radiation. (orig.)

  8. Atraso diagnóstico do retinoblastoma

    OpenAIRE

    Rodrigues,Karla E. S.; Latorre,Maria do Rosário D. O.; Camargo,Beatriz de

    2004-01-01

    OBJETIVOS: Identificar os principais sinais e sintomas do retinoblastoma e determinar o tempo médio entre o início dos sintomas e o diagnóstico. MÉTODOS: Estudo retrospectivo, com revisão dos prontuários das crianças diagnosticadas com retinoblastoma entre janeiro de 1991 e junho de 2000 no Departamento de Pediatria do Hospital do Câncer de São Paulo. Análise estatística: teste t de Student, análise e variância, teste de Tukey-HSD (honest significant differences), teste de Levene, análise de ...

  9. Postirradiation sarcoma in retinoblastoma. Induction or predisposition

    International Nuclear Information System (INIS)

    Schwarz, M.B.; Burgess, L.P.; Fee, W.E. Jr.; Donaldson, S.S.

    1988-01-01

    An alarmingly high rate of postirradiation sarcomas following treatment for retinoblastoma has been described in the literature. We present four new cases and report 57 others from the English literature. Osteogenic sarcoma was the predominant histologic type (58%), followed by fibrosarcoma (21%) and various other sarcomas (21%). The average latency period between irradiation and development of the second primary (sarcoma) was 12.4 years. Irrespective of irradiation, a genetic linkage between retinoblastoma and osteogenic sarcoma on the 13q14 chromosome is recognized. Through a pleiotropic effect of this same chromosome, a predisposition for other sarcomas may exist as well. Finally, a strong role for radiation induction is proposed for all of these postirradiation sarcomas. This is based on the increased number of sarcomas arising in the field of prior irradiation (sites uncharacteristic of spontaneously occurring primary sarcomas) and the prolonged latency periods.13 references

  10. Imaging in the trilateral retinoblastoma syndrome

    International Nuclear Information System (INIS)

    Bagley, L.J.; Hurst, R.W.; Zimmerman, R.A.; Shields, J.A.; Shields, C.L.; De Potter, P.

    1996-01-01

    The medical records, CT, and MRI of ten children with trilateral retinoblastoma were reviewed. The intracranial pathology consisted of eight pineal neoplasms and two parasellar lesions, at least seven of the which were calcified. Two lesions demonstrated calcification only (no soft tissue mass) at initial presentation. Hydrocephalus was seen in eight cases, and concurrent or subsequent subarachnoid dissemination was documented in seven. Only one patient is known to be alive at the present time. The imaging features of the midline intracranial tumors mirror those of the ocular neoplasm. As calcification may be the only clue to the presence of the intracranial malignancy, close surveillance of high-risk patients with retinoblastoma with initial CT and follow-up MRI is suggested. (orig.). With 3 figs., 1 tab

  11. Imaging in the trilateral retinoblastoma syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Bagley, L.J. [Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104 (United States); Hurst, R.W. [Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104 (United States); Zimmerman, R.A. [Department of Radiology, Children`s Hospital of Philadelphia, 34 th St. and Civic Center Blvd., Philadelphia, PA 19104 (United States); Shields, J.A. [Ocular Oncology Service, Wills Eye Hospital, 900 Walnut St., Philadelphia, PA 19107 (United States); Shields, C.L. [Ocular Oncology Service, Wills Eye Hospital, 900 Walnut St., Philadelphia, PA 19107 (United States); De Potter, P. [Ocular Oncology Service, Wills Eye Hospital, 900 Walnut St., Philadelphia, PA 19107 (United States)

    1996-02-01

    The medical records, CT, and MRI of ten children with trilateral retinoblastoma were reviewed. The intracranial pathology consisted of eight pineal neoplasms and two parasellar lesions, at least seven of the which were calcified. Two lesions demonstrated calcification only (no soft tissue mass) at initial presentation. Hydrocephalus was seen in eight cases, and concurrent or subsequent subarachnoid dissemination was documented in seven. Only one patient is known to be alive at the present time. The imaging features of the midline intracranial tumors mirror those of the ocular neoplasm. As calcification may be the only clue to the presence of the intracranial malignancy, close surveillance of high-risk patients with retinoblastoma with initial CT and follow-up MRI is suggested. (orig.). With 3 figs., 1 tab.

  12. Radiation management of retinoblastoma; An analysis

    Energy Technology Data Exchange (ETDEWEB)

    Takemasa, Kazuhiko; Ito, Hisao; Hashimoto, Shozo; Tanaka, Yasuhiko; Oguchi, Yoshihisa (Keio Univ., Tokyo (Japan). School of Medicine)

    1991-12-01

    An analysis has been conducted of 45 patients treated for retinoblastoma at Keio University Hospital between 1970 and 1990. Of these patients, 32 had unilateral lesion and 13 had bilateral lesion. Further, since their disease was far advanced, 29 patients with unilateral lesion and 12 patients with bilateral lesion underwent enucleation. As a result, 3 patients with unilateral retinoblastoma and all patients with bilateral manifestation of the disease were treated with radiotherapy (45-50 Gy) with or without cryotherapy and photocoagulation. One patient with unilateral lesion, who had received both radiotherapy and chemotherapy, showed metastases at the first presentation at our clinic and thus was excluded from this analysis. Among 16 eyes of 15 patients who were given radiotherapy, 6 eyes developed recurrence and needed to have further treatment. In 6 eyes out of 12, cataract developed, and out of 10 eyes in which eye function was evaluable, good vision was able to be preserved in 5 eyes. (author).

  13. Diffuse infiltrating retinoblastoma invading subarachnoid space

    Directory of Open Access Journals (Sweden)

    Kase S

    2011-06-01

    Full Text Available Satoru Kase1, Kazuhiko Yoshida1, Shigenobu Suzuki2, Koh-ichi Ohshima3, Shigeaki Ohno4, Susumu Ishida11Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo; 2Department of Ophthalmic Oncology, National Cancer Center Hospital, Tokyo; 3Section of Ophthalmology, Okayama Medical Center, Okayama; 4Department of Ocular Inflammation and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, JapanAbstract: We report herein an unusual case of diffuse infiltrating retinoblastoma involving the brain, which caused a patient’s death 27 months after enucleation. An eight-year-old boy complained of blurred vision in his right eye (OD in October 2006. Funduscopic examination showed optic disc swelling, dense whitish vitreous opacity, and an orange-colored subretinal elevated lesion adjacent to the optic disc. Fluorescein angiography revealed hyperfluorescence in the peripapillary region at an early-phase OD. Because the size of the subretinal lesion and vitreous opacity gradually increased, he was referred to us. His visual acuity was 20/1000 OD on June 20, 2007. Slit-lamp biomicroscopy showed a dense anterior vitreous opacity. Ophthalmoscopically, the subretinal orange-colored area spread out until reaching the mid peripheral region. A B-mode sonogram and computed tomography showed a thick homogeneous lesion without calcification. Gadolinium-enhanced magnetic resonance imaging showed a markedly enhanced appearance of the underlying posterior retina. Enucleation of the right eye was performed nine months after the initial presentation. Histopathology demonstrated retinal detachment and a huge choroidal mass invading the optic nerve head. The tumor was consistent with diffuse infiltrating retinoblastoma. The patient died due to brain involvement 27 months after enucleation. Ophthalmologists should be aware that diffuse infiltrating retinoblastoma may show an unfavorable course if its diagnosis is delayed

  14. MicroRNAs horizon in retinoblastoma.

    Directory of Open Access Journals (Sweden)

    Mojgan Mirakholi

    2013-12-01

    Full Text Available In the retinoblastoma research, it is of great interest to identify molecular markers associated with the genetics of tumorigenesis. microRNAs (miRNAs are small non-coding RNA molecules that play a regulatory role in many crucial cellular pathways such as differentiation, cell cycle progression, and apoptosis. A body of evidences showed dysregulation of miRNAs in tumor biology and many diseases. They potentially play a significant role in tumorigenesis processes and have been the subject of research in many types of cancers including retinal tumorigenesis. miRNA expression profiling was found to be associated with tumor development, progression and treatment. These associations demonstrate the putative applications of miRNAs in monitoring of different aspect of tumors consisting diagnostic, prognostic and therapeutic. Herein, we review the current literature concerning to the study of miRNA target recognition, function to tumorigenesis and treatment in retinoblastoma. Identification the specific miRNA biomarkers associated with retinoblastoma cancer may help to establish new therapeutic approaches for salvage affected eyes in patients.

  15. Genetics and Molecular Diagnostics in Retinoblastoma--An Update.

    Science.gov (United States)

    Soliman, Sameh E; Racher, Hilary; Zhang, Chengyue; MacDonald, Heather; Gallie, Brenda L

    2017-01-01

    Retinoblastoma is the prototype genetic cancer: in one or both eyes of young children, most retinoblastomas are initiated by biallelic mutation of the retinoblastoma tumor suppressor gene, RB1, in a developing retinal cell. All those with bilateral retinoblastoma have heritable cancer, although 95% have not inherited the RB1 mutation. Non-heritable retinoblastoma is always unilateral, with 98% caused by loss of both RB1 alleles from the tumor, whereas 2% have normal RB1 in tumors initiated by amplification of the MYCN oncogene. Good understanding of retinoblastoma genetics supports optimal care for retinoblastoma children and their families. Retinoblastoma is the first cancer to officially acknowledge the seminal role of genetics in cancer, by incorporating "H" into the eighth edition of cancer staging (2017): those who carry the RB1 cancer-predisposing gene are H1; those proven to not carry the familial RB1 mutation are H0; and those at unknown risk are HX. We suggest H0* be used for those with residual <1% risk to carry a RB1 mutation due to undetectable mosaicism. Loss of RB1 from a susceptible developing retinal cell initiates the benign precursor, retinoma. Progressive genomic changes result in retinoblastoma, and cancer progression ensues with increasing genomic disarray. Looking forward, novel therapies are anticipated from studies of retinoblastoma and metastatic tumor cells and the second primary cancers that the carriers of RB1 mutations are at high risk to develop. Here, we summarize the concepts of retinoblastoma genetics for ophthalmologists in a question/answer format to assist in the care of patients and their families. Copyright 2017 Asia-Pacific Academy of Ophthalmology.

  16. Desarrollo multinivel: Implicaciones macro-regional, local y micro- regional

    Directory of Open Access Journals (Sweden)

    José Guadalupe Vargas Hernández

    2006-11-01

    Full Text Available Este trabajo se propone analizar las implicaciones del desarrollo en los niveles macro-regional, local y micro- regional, a partir de la hipótesis central de la teoría del desarrollo que plantea que el desarrollo económico traerá consigo el desarrollo político y social. Después de hacer de un acercamiento conceptual al desarrollo, se repasan brevemente las teorías del desarrollo existentes como herramientas de análisis de la realidad. En la discusión se concluye que los procesos de desarrollo locales y regionales requieren de una transformación sustancial de las relaciones negociadas entre los agentes económicos y los actores políticos. Ante el paulatino retroceso que en las sociedades contemporáneas está teniendo el Estado de bienestar, uno de los principales retos es el empoderamiento de las organizaciones sociales y comunitarias para que desempeñen activamente su rol en los procesos de desarrollo local y regional.

  17. Características de la estructura molecular de las proteínas E del virus del Zika y E1 del virus de la rubéola y posibles implicaciones en el neurotropismo y en las alteraciones del sistema nervioso

    Directory of Open Access Journals (Sweden)

    Luis Alberto Gómez

    2017-04-01

    Conclusión. La comparación de las proteínas E-ZIKV y E1-RV es un paso necesario hacia la definición de otros factores moleculares determinantes del neurotropismo y la patogenia del ZIKV, el cual puede contribuir a generar estrategias de diagnóstico, prevención y tratamiento de las complicaciones neurológicas inducidas por el ZIKV.

  18. Implicaciones teóricas y empíricas de la nueva definición de desempleo en Colombia.

    OpenAIRE

    Guataquí, Juan; Taborda, Rodrigo

    2005-01-01

    En junio de 2000 Colombia adoptó una nueva definición de desempleo siguiendo los estándares de la OIT. Este cambio implicó una reducción de la tasa de desempleo del orden de dos puntos porcentuales. En este documento contrastamos el caso Colombiano con las experiencias de otros países en términos de la transformación metodológica y sus implicaciones empíricas. Posteriormente, evaluamos el soporte empírico del cambio de metodología. Nuestros resultados sugieren implicaciones esp...

  19. Retinoblastoma: Assessing the Level of Knowledge of Tumour By ...

    African Journals Online (AJOL)

    For 60% leucocoria was the only sign suspect of retinoblastoma, for 80% strabismus was the only sign of retinoblastoma, only 10% had associated leucocoria and strabismus as two early signs of this cancer. Twelve percent had a score equal to 3/3, eight (8%) had a score equal to 2/3, and 80% had a score of less than or ...

  20. Cancer incidence after retinoblastoma - Radiation dose and sarcoma risk

    NARCIS (Netherlands)

    Wong, FL; Boice, JD; Abramson, DH; Tarone, RE; Kleinerman, RA; Stovall, M; Goldman, MB; Seddon, JM; Tarbell, N; Fraumeni, JF; Li, FP

    1997-01-01

    Context.-There is a substantial risk of a second cancer for persons with hereditary retinoblastoma, which is enhanced by radiotherapy. Objective.-To examine long-term risk of new primary cancers in survivors of childhood retinoblastoma and quantify the role of radiotherapy in sarcoma development.

  1. Inhibitory effect of puerarin on proliferation of retinoblastoma cells ...

    African Journals Online (AJOL)

    ... 71.4 ± 4.5 % for control and Bmi-1 siRNA-treated groups, respectively. Conclusions: The results show that puerarin exert suppressive effects on human retinoblastoma Y79 cells and therefore may find application in the treatment of intraocular tumor. Keywords: Cancer, Puerarin, Retinoblastoma Y79 cells, mTOR inhibition, ...

  2. Variabilidad morfológica craneofacial en el valle inferior del Rio Negro: implicaciones para el análisis de la dinámica poblacional en nordpatagonia y en el sudeste de la Región Pampeana

    Directory of Open Access Journals (Sweden)

    Pérez, Sergio Iván

    2001-01-01

    Full Text Available Recientemente se propuso, en base a distintas líneas de evidencia arqueológica y bioarqueológica, que los grupos humanos que habitaron el Sudeste de la Región Pampeana en distintos momentos del Holoceno fueron poblaciones locales pertenecientes a metapoblaciones alocrónicas, con un rango de distribución geográfica desconocido, pero que probablemente abarcó regiones vecinas como el norte de la Pampa Húmeda, Pampa Seca, Sierras Centrales y el norte de Patagonia. Con el fin de poner a prueba tales hipótesis, se diseñó una investigación orientada a establecer, en cada caso, el grado de similitud morfológica a nivel craneofacial (tamaño y forma, mediante análisis discriminante aplicado a variables Howellianas. En una primera etapa se analizaron muestras masculinas y femeninas provenientes del valle inferior del Río Negro (colección del Museo de La Plata; n= 133, de cronología desconocida, y muestras diacrónicas del Sudeste de la Región Pampeana, con cronología determinada radiocarbónicamente (n= 36. Los resultados preliminares muestran que: a gran parte de la variabilidad registrada en la muestra de Río Negro tiene su correlato en la registrada en la Región Pampeana, lo que sugiere una estrecha relación biológica entre los habitantes prehispánicos de estas dos regiones, y b la muestra del valle del Río Negro está probablemente integrada por individuos correspondientes a distintos momentos del Holoceno.

  3. Retinoblastoma bilateral de aparecimento tardio: relato de caso Late presentation of bilateral retinoblastoma: case report

    Directory of Open Access Journals (Sweden)

    Maria Cecília Santos Cavalcanti Melo

    2008-06-01

    Full Text Available É relatado um caso de retinoblastoma de aparecimento tardio, com características pouco freqüentes, com o objetivo de melhorar o controle da afecção. Em 1993, SJMMF, nove meses, masculino, leucodermo, apresentou tumor na retina esquerda. O paciente tinha história familiar de retinoblastoma. A enucleação foi realizada, comprovando-se retinoblastoma. Os exames para estadiamento sistêmico foram normais. O olho direito evoluiu normal por dez anos. Em exame de rotina, foram constatadas três lesões de retinoblastoma na retina nasal. Foi feita termoterapia transpupilar, com laser de diodo de 810 nm. Após 30 dias, as lesões regrediram. Após 60 dias houve recidiva na borda da lesão, onde foi realizada crioterapia transescleral, com regressão do tumor por seis meses. Durante o controle, observaram-se condensações próximas à lesão tumoral atrófica (sementes vítreas. Foi feito braquiterapia com Iodo125, havendo desaparecimento das mesmas após 30 dias. Novas sementes surgiram três meses pós-braquiterapia, depositadas na superfície retiniana, sendo tratadas com crioterapia transescleral e termoterapia transpupilar, havendo regressão. O paciente evoluiu com nova semente vítrea após seis meses, a qual, após depositar-se na superfície da retina, foi tratada com termoterapia transpupilar. Está em seguimento há 38 meses desde o aparecimento do tumor bilateral, mantendo acuidade visual de 20/20 e exames clínicos normais. Considera-se importante este caso pela pouca freqüência de aparecimento da doença nesta idade. Julga-se necessário o alerta para os casos de retinoblastoma já considerados curados.A case of retinoblastoma with uncommon features is reported, aiming at improving follow-up. In 1993, SJMMF, 9-month-old white boy, presented a squint in the left eye. A retinal tumor was detected. The patient had a family history of retinoblastoma. Enucleation was performed and retinoblastoma was proved. The patient underwent

  4. The effects of BSO on GSH contents and radiosensitivity of retinoblastoma cells

    International Nuclear Information System (INIS)

    Yi Xanjin; Ding Li; Jin Yizun; Ni Chuo; Wang Wenji; Yi Yuzhen

    1995-01-01

    The radiobiological effects of thiol modifier BSO on retinoblastoma were studied using cultured retinoblastoma cell lines Y-79 and So-Rb 50 and retinoblastoma bearing nude mouse. The preliminary results showed that BSO can deplete intracellular GSH contents of retinoblastoma cells in vitro and vivo. In vitro data demonstrated that low and nontoxic concentration BSO increased the retinoblastoma cells radiosensitivity especially under the hypoxic condition

  5. Histopathologic grading of anaplasia in retinoblastoma.

    Science.gov (United States)

    Mendoza, Pia R; Specht, Charles S; Hubbard, G Baker; Wells, Jill R; Lynn, Michael J; Zhang, Qing; Kong, Jun; Grossniklaus, Hans E

    2015-04-01

    To determine whether the degree of tumor anaplasia has prognostic value by evaluating its correlation with high-risk histopathologic features and clinical outcomes in a series of retinoblastoma patients. Retrospective clinicopathologic study. The clinical and pathologic findings in 266 patients who underwent primary enucleation for retinoblastoma were reviewed. The histologic degree of anaplasia was graded as retinocytoma, mild, moderate, or severe as defined by increasing cellular pleomorphism, number of mitoses, nuclear size, and nuclear hyperchromatism. Nuclear morphometric characteristics were measured. The clinical and pathologic data of 125 patients were compared using Kaplan-Meier estimates of survival. Fisher exact test and multivariate regression were used to analyze the association between anaplasia grade and high-risk histologic features. Increasing grade of anaplasia was associated with decreased overall survival (P = .003) and increased risk of metastasis (P = .0007). Histopathologic features that were associated with anaplasia included optic nerve invasion (P anaplasia grading as predictors of distant metastasis and death showed that high-risk histopathology was statistically significant as an independent predictor (P = .01 for metastasis, P = .03 for death) but anaplasia was not (P = .63 for metastasis, P = .30 for death). In the absence of high-risk features, however, severe anaplasia identified an additional risk for metastasis (P = .0004) and death (P = .01). Grading of anaplasia may be a useful adjunct to standard histopathologic criteria in identifying retinoblastoma patients who do not have high-risk histologic features but still have an increased risk of metastasis and may need adjuvant therapy. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Trilateral retinoblastoma with unilateral eye involvement

    Directory of Open Access Journals (Sweden)

    Gabriel Costa de Andrade

    2015-08-01

    Full Text Available SummaryRetinoblastomas (RB are the main forms of intraocular tumor in childhood, with a worldwide incidence of 1 case per 15,000 to 20,000 live births. Trilateral RB (RBT is a rare combination of unilateral or bilateral RB with a midline intracranial neoplasm of neuroblastic origin, usually found in the pineal region or the suprasellar region, presenting variable incidence of 0.5% up to 6% among patients with RB. The article reports a case of unilateral RBT in a patient treated at Hospital A.C.Camargo.

  7. Implicaciones de las moléculas de adhesión celular neural en los efectos del estrés en procesos de aprendizaje y memoria en la rata

    OpenAIRE

    Merino Martín, José Joaquín

    2002-01-01

    Dado que las glicoproteínas denominadas moléculas de adhesión celular neural (NCAM, su forma polisializada, PSA-NCAM, y LI) desempeñan un papel importante en la consolidación de la memoria, se estudió su expresión en diferentes regiones cerebrales, en ratas entrenadas en el paradigma conductual del condicionamiento del miedo al contexto, bajo diferentes niveles de estrés intrínseco (ligado a la tarea de aprendizaje), y a diferentes tiempos post-entremamiento (12 y 24 horas). También se estudi...

  8. La sostenibilidad en el currículo de las carreras de arquitectura: Implicaciones del concepto de sostenibilidad en el perfil profesional y el plan de estudios de las carreras de arquitectura en América Latina

    OpenAIRE

    Alexander González C.; Maureen Trebilcock K.

    2012-01-01

    La formación y la práctica profesional de los arquitectos deben corresponder con las necesidades y tendencias sociales, económicas y ambientales de su contexto, a partir del desarrollo sostenible como marco de referencia. Esta condición es relevante en la comunidad latinoamericana, donde la formación en arquitectura es uno de los principales factores de oportunidad para la futura transformación del ambiente construido, mediante la definición de competencias científicas, técnicas y proyectuale...

  9. The federal law of the Revenue Agency responsibility, the national oil industry and the determination of the average price of the Mexican mixture for export: implications and limitations; La ley federal de responsabilidad hacendaria, la industria petrolera nacional y la determinacion del precio promedio de la mezcla mexicana de exportacion: implicaciones y limitaciones

    Energy Technology Data Exchange (ETDEWEB)

    Baltierra, Lauro; Huerta, Carlos E.; Ruiz Alarcon, Fluvio Cesar [LX legislatura, Camara de Diputados, Mexico, D.F. (Mexico)

    2006-11-15

    en la economia del pais, al propiciar un proceso de financiarizacion del sector, asi como las implicaciones que se originan de la fijacion inamovible del precio del petroleo por disposicion legal. Como ello limita las potestades constitucionales de la Camara de Diputados al negarle la facultad, que ejercia hasta la expedicion de la Ley, para evaluar las estimaciones del Ejecutivo Federal respecto al precio promedio de la mezcla mexicana de exportacion. En el primer apartado se realiza un balance de como el Presupuesto de Egresos de la Federacion se proyecta como un instrumento para frenar la inversion publica en el sector petrolero. En el segundo se atienden aspectos relacionados con la estimacion de precio del petroleo a partir de la Ley de Federal de Presupuesto y Responsabilidad Hacendaria, senalando las incongruencias que significa establecer una formula para la determinacion del mismo. En un tercer apartado, se tratan la subvaluacion de los precios del crudo como factor clave para el uso discrecional de los excedentes petroleros. En el cuarto apartado, se analizan los Criterios Generales de Politica Economica para el ano 2007, que conforme a la nueva Ley Federal de Presupuesto y Responsabilidad Hacendaria fueron remitidos a la Camara de Diputados por el Ejecutivo Federal en el mes de abril. Por ultimo, se presentan las estimaciones de la mezcla mexicana de exportacion para 2007 que a consideracion de los autores oscilara entre 50 y 51 dolares como promedio anual.

  10. Human Papilloma Virus in Retinoblastoma Tissues from Korean Patients

    Science.gov (United States)

    Ryoo, Na-Kyung; Kim, Ji-Eun; Kim, Namju; Lee, Min-Jeong; Khwarg, Sang-In

    2013-01-01

    Purpose Recent reports suggest the association of human papilloma virus (HPV) with retinoblastoma. This study was performed to elucidate whether HPV infection is related to retinoblastoma among Koreans. Methods A total of 54 cases diagnosed with retinoblastoma were enrolled from Seoul National University Children's Hospital and Seoul Metropolitan Government-Seoul National University Boramae Medical Center. Presence of human papilloma viral DNA was detected by in situ hybridization in formalin-fixed paraffin-embedded retinoblastoma tissues using both probes against high- and low risk HPV types. Results The mean age at diagnosis was 22.0 months (range, 1.1 to 98.0 months), and the mean age at enucleation was 27.8 months (range, 1.5 to 112.7 months) among the 54 patients with retinoblastoma. HPV was not detected in any of the retinoblastoma samples using either high risk or low risk HPV probes. Conclusions Our study, being the first study in the Korean population, proposes that HPV infection may have no causal relationship with retinoblastoma in Koreans. PMID:24082775

  11. Clinical Value of CD24 Expression in Retinoblastoma

    Directory of Open Access Journals (Sweden)

    Jia Li

    2012-01-01

    Full Text Available Background. The expression of CD24 has been detected in a wide variety of human malignancies. Downregulation of CD24 inhibits proliferation and induces apoptosis in tumor cells, whereas its upregulation increases tumor growth and metastasis. However, no data on CD24 protein levels in retinoblastoma are available, and the mechanism of CD24 involvement in retinoblastoma progress has not been elucidated. The aim of this study was to explore the expression profile of CD24 in the retinoblastoma tumor samples and to correlate with clinicopathological parameters. Methods. Immunohistochemistry was performed for CD24 on the archival paraffin sections of retinoblastoma and correlated with clinicopathological features. Western blotting was performed to confirm immunoreactivity results. Results. CD24 immunoreactivity was observed in 72.0% (36/50 of the retinoblastoma specimens. Among the 35 low-risk tumors, CD24 was expressed in 62.9% (22/35 tumors and among the 15 high-risk tumors, CD24 was expressed in 93.3% (14/15 tumors. High-risk tumors showed significantly increased expression of CD24 compared to tumors with low-risk (<0.05. Conclusions. This is the first correlation between CD24 expression and histopathology in human retinoblastoma. Our study showed increased expression of CD24 in high risk tumors compared to low risk tumors. Further functional studies are required to explore the role of CD24 in retinoblastoma.

  12. Diffuse Anterior Retinoblastoma with Sarcoidosis-Like Nodule

    Directory of Open Access Journals (Sweden)

    Koji Kitazawa

    2015-12-01

    Full Text Available Background: Retinoblastomas account for 4% of malignancies in children, 1-2% of which are diffuse infiltrating retinoblastomas. Diffuse anterior retinoblastoma is rare and does not involve the retina. Here, we report on a diffuse anterior retinoblastoma with large sarcoidosis-like nodules on the iris that were responsive to anti-inflammatory therapy. Case: We present a 6-year-old girl who had anterior uveitis with white nodules on the iris and posterior surface of the cornea in her right eye. The nodules initially responded well to anti-inflammatory treatment. However, anterior segment optical coherence tomography (AS-OCT showed that the nodules gradually grew, shrinking the iris. We then collected the aqueous humor for diagnosis. A biopsy revealed clusters of small cells with a high nuclear-to-cytoplasm ratio with partial rosette formation. Therefore, we diagnosed diffuse anterior retinoblastoma without retinal involvement and performed enucleation of the right eye. The histopathology demonstrated undifferentiated cells similar to those seen on the biopsy, and tumor cells invaded the iris stroma, posterior surface of the cornea, ciliary body, and sclera. After the enucleation, she underwent chemotherapy and remains alive. Conclusion: A differential diagnosis of retinoblastoma should be considered when white nodules refractory to anti-inflammatory therapy occur in the eye, even in the absence of obvious retinal masses. AS-OCT findings are useful in assessing retinoblastoma.

  13. La erosión y sus implicaciones en la morfología de la micro cuenca del Igarapé Apeú, Estado do Pará, Brasil

    Directory of Open Access Journals (Sweden)

    Odete Cardoso de Oliveira Santos

    2007-01-01

    Full Text Available Las aguas de los canales que componen la micro cuenca del canal Apeú, ubicada en el nordeste del estado del Pará, en tierras de los municipios de Castanhal (70%, Inhangapí (10% y Santa Isabel do Pará (20%, son muy aprovechadas por los ribereños y pequeños campesinos. Por eso, en esta investigación se muestra que la erosión acelerada por las actividades antrópicas contribuye a los cambios de la morfología de  los  canales  fluviales  que  componen  la  microcuenca.  Para  medir  la  erosión  en  pendiente  se  empleó  la metodología de las estacas; para la erosión marginal en los canales se utilizó la metodología de los Pinos y de las Estacas. Los análisis fisicoquímicas de los sedimentos de los barrancos y del fondo de los canales fueron determinados por las técnicas descriptas por Guimarães et al. (1970, EMBRAPA (1997 y  Silva (1999. La profundidad de los canales se midió usando el molinete en vado, en el momento de las mediciones de los caudales en las secciones transversales de los canales. De acuerdo con los resultados, la pérdida de suelo por la erosión de la pendiente llegó a 74,02 m en el periodo de octubre de 2002 a julio de 2003. El canal Apeú, el principal de la microcuenca, en la hacienda Morro Verde abandonó su lecho normal por espacio de 50 metros, a causa de los sedimentos provenientes de surcos, zanjas y barrancos formados en el interior de la hacienda mencionada. En ese mismo canal, en el periodo menos lluvioso, en la villa agrícola de Macapazinho, en la mitad del lecho, el nivel de las aguas alcanzó  0,5 m; en el periodo lluvioso llegó a 3,0 m. En los canales predomina la carga del lecho.

  14. La erosión y sus implicaciones en la morfología de la micro cuenca del Igarapé Apeú, Estado do Pará, Brasil

    Directory of Open Access Journals (Sweden)

    de Oliveira Santos Odete Cardoso

    2007-11-01

    Full Text Available Las aguas de los canales que componen la micro cuenca del canal Apeú, ubicada en el nordeste del estado del Pará, en tierras de los municipios de Castanhal (70%, Inhangapí (10% y Santa Isabel do Pará (20%, son muy aprovechadas por los ribereños y pequeños campesinos. Por eso, en esta investigación se muestra que la erosión acelerada por las actividades antrópicas contribuye a los cambios de la morfología de los canales fluviales que componen la microcuenca. Para medir la erosión en pendiente se empleó la metodología de las estacas; para la erosión marginal en los canales se utilizó la metodología de los Pinos y de las Estacas. Los análisis fisicoquímicas de los sedimentos de los barrancos y del fondo de los canales fueron determinados por las técnicas descriptas por Guimarães et al. (1970, EMBRAPA (1997 y Silva (1999. Laprofundidad de los canales se midió usando el molinete en vado, en el momento de las mediciones de los caudales en las secciones transversales de los canales. De acuerdo con los resultados, la pérdida de suelo por la erosión de la pendiente llegó a 74,02 m en el periodo de octubre de 2002 a julio de 2003. El canal Apeú, el principal de la microcuenca, en la hacienda Morro Verde abandonó su lecho normal por espacio de 50 metros, a causa de los sedimentos provenientes de surcos, zanjas y barrancos formados en el interior de la hacienda mencionada. En ese mismo canal, en el periodo menos lluvioso, en la villa agrícola de Macapazinho, en la mitad del lecho, el nivel de las aguas alcanzó 0,5 m; en el periodo lluvioso llegó a 3,0 m. En los canales predomina la carga del lecho.

  15. Programa nacional de prevención y consejería genética del retinoblastoma mediante detección de mutaciones en el gen RB.

    Directory of Open Access Journals (Sweden)

    H. Frayle

    2001-07-01

    una la doble mutación inactivante del gen Rb, exclusivamente somática en los esporádicos y germinal más somática en los hereditarios. Esta investigacin tuvo como objetivo caracterizar las mutaciones en el gen Rb mediante secuenciación directa y evaluar su utilidad en la consejería genética.

  16. Global issues and opportunities for optimized retinoblastoma care.

    Science.gov (United States)

    Gallie, Brenda L; Zhao, Junyang; Vandezande, Kirk; White, Abigail; Chan, Helen S L

    2007-12-01

    The RB1 gene is important in all human cancers. Studies of human retinoblastoma point to a rare retinal cell with extreme dependency on RB1 for initiation but not progression to full malignancy. In developed countries, genetic testing within affected families can predict children at high risk of retinoblastoma before birth; chemotherapy with local therapy often saves eyes and vision; and mortality is 4%. In less developed countries where 92% of children with retinoblastoma are born, mortality reaches 90%. Global collaboration is building for the dramatic change in mortality that awareness, simple expertise and therapies could achieve in less developed countries. Copyright 2007 Wiley-Liss, Inc.

  17. Multifocal osteosarcoma as second tumor after childhood retinoblastoma

    International Nuclear Information System (INIS)

    Potepan, P.; Laffranchi, A.; Danesini, G.M.; Spagnoli, I.; Luksch, R.; Sozzi, G.; Testi, A.; Parafioriti, A.; Giardini, R.

    1999-01-01

    We present a case of multifocal osteosarcoma (MFOS) arising 11.5 years after successful treatment of bilateral retinoblastoma. The clinical, imaging and pathological findings at onset, after therapy, and during follow-up are described. Fluorescent in situ hybridization did not reveal a deletion of the RB-1 retinoblastoma gene, although the presence of an inactivating mutation invisible to this method cannot be ruled out. The MFOS may have been a second multifocal tumor associated with the original retinoblastoma or a post-irradiation sarcoma with extensive metastases. (orig.)

  18. Descripción histológica del ojo de Panaque nigrolineatus (Siluriformes: Loricariidae) y sus implicaciones ecomorfológicas Histological structure of the eye of Panaque nigrolineatus (Siluriformes: Loricariidae), ecomorphological implications

    OpenAIRE

    SHERYLL CORCHUELO; MARIA L CALDAS; RENATO PEÑA; HERNÁN HURTADO; MARIO O TOVAR

    2012-01-01

    La cucha real (Panaque nigrolineatus) es endémica de las cuencas del Orinoco y Amazonas. La información relacionada con el sistema visual de esta especie es muy escasa, a pesar de ser un sentido fundamental en la interacción del individuo con su ambiente. Los especímenes se clasificaron en dos grupos en base a su tamano corporal: pequenos (longitud estándar (media ± DE) de 5.92 ± 1.43 cm y peso promedio de 8.50 ± 6.8 g) y grandes (longitud estándar (media ± DE) de 15.9 ± 0.69 cm y peso promed...

  19. PERFIL DE RIESGO DE LAS COOPERATIVAS DE CRÉDITO ESPAÑOLAS: IMPLICACIONES EN EL COSTE DEL SEGURO DE DEPÓSITO / RISK PROFILE OF SPANISH CREDIT COOPERATIVES: IMPLICATIONS FOR THE COST OF DEPOSIT INSURANCE

    Directory of Open Access Journals (Sweden)

    Antonio PARTAL UREÑA

    2012-09-01

    Full Text Available La reforma propuesta por la Comisión Europea en julio de 2010, modificando el procedimiento para fijar las aportaciones que deben realizar las entidades de crédito a los sistemas de garantía de depósitos en función de su nivel de riesgo, supondrá cambios sustanciales en las cuotas que pagan actualmente. Este trabajo analiza el perfil de riesgo de las cooperativas españolas durante el período 2007-2010 y cuantifica su efecto sobre las contribuciones al Fondo de Garantía de Depósitos de Entidades de Crédito (FGDEC aplicando la metodología desarrollada por la Comisión. El estudio concluye con importantes evidencias sobre la evolución del perfil de riesgo del sector durante un periodo de recesión económica y el impacto de esta reforma, valorado a través del número de entidades que aumentarían su aportación y las variaciones en el coste del seguro respecto al sistema vigente. / The reform proposed by the European Commission in July 2010, modifying the procedure for determining the contributions which the banks must make to the deposit guarantee systems according to their level of risk will imply substantial changes in the fees currently paid. This paper analyzes the risk profile of Spanish cooperatives during 2007-2010 and quantifies their effect on contributions to the Deposit Guarantee Fund for Credit Institutions (FGDEC using the methodology proposed by the Commission. The study concludes with important evidence about the evolution of the risk profile of the sector in a period of economic recession and the impact of this reform, measured by means of the number of entities that would increase their input and variations in the cost of insurance in relation to the current system.

  20. Implicaciones de la asesoría de prensa para la definición del posicionamiento de marca/ Implications of the press office for the definition of branding

    Directory of Open Access Journals (Sweden)

    Paula ARRISCADO

    2015-07-01

    Full Text Available El presente trabajo pretende reflejar de qué forma la asesoría de prensa puede contribuir en el proceso de construcción de la identidad de las marcas y cuál es el rol que a través de las relaciones informativas desempeñan los profesionales del periodismo y los consumidores, en términos de definición del posicionamiento. Para ello se estudia, de un modo exploratorio, si las noticias publicadas a partir de la información facilitada por los gestores de comunicación de una marca del sector del automóvil para uno de sus productos, están en consonancia o en disonancia con el posicionamiento definido por la propia marca Los resultados parecen poner de manifiesto que, de un modo general, existe coincidencia y que los medios de comunicación de masas pueden contribuir en la activación de los atributos/ o beneficios del producto. Sin embargo, se verificó, también, que la narrativa periodística puede activar otros atributos de la identidad de marca, más allá de los pretendidos por los gestores de comunicación. This paper aims to reflect how the press office can contribute to the process of building the brand identity and what is the role through the reporting relationships play journalism professionals and consumers, in terms of definition positioning. To do this we study, an exploratory mode, if published since the information provided by the managers of communication of a brand of car for one of its products sector news are in line or at odds with the position defined by the own bran. The results seem to show that, in general, there is agreement that the mass media can contribute in activating the attributes / or benefits of the product. However, it was observed, too, that the journalistic narrative can activate other attributes of the brand identity, beyond those intended by the managers of communication.

  1. Ambiente do Centro Cirúrgico e os elementos que o integram: implicações para os cuidados de enfermagem Ambiente del quirófano y sus elementos: implicaciones para la atención de enfermería Surgical Center environment and its elements: implications for nursing care

    Directory of Open Access Journals (Sweden)

    Denise Conceição Silva

    2010-06-01

    Full Text Available Pesquisa qualitativa que objetivou caracterizar os elementos que integram o ambiente do Centro Cirúrgico e analisar suas implicações para a dinâmica de cuidar e de cuidados de enfermagem. Ancorou-se nos princípios da Teoria Ambientalista. Participaram 12 enfermeiras do centro cirúrgico de um Hospital Universitário do Rio de Janeiro. Os dados foram produzidos pela técnica de criatividade e sensibilidade "Mapa-Falante", entrevista semi-estruturada e observação participante; e analisados por categorias temáticas. Os resultados apontam que o cuidado ocorre direta e indiretamente, em prol da plena restauração do cliente, incluindo o ambiente que o integra, de modo a manter-se harmônico e equilibrado. As intervenções da enfermeira são no sentido de manter o ambiente em condições favoráveis de modo a torná-lo promotor de cuidados.Investigación cualitativa que objetivó caracterizar los elementos que integran el ambiente del quirófano y analizar sus implicaciones para la dinamica del cuidar y del cuidado de enfermería. Basada en los principios de la Teoría Ambientalista. Participaran 12 enfermeras del quirófano de un Hospital Universitario del Río de Janeiro. Los datos foran producidos por la técnica de creatividad y sensibilidad "Mapa-Hablante", entrevista semi estructurada y observación participante; y analizados por categorías temáticas. Los resultados apuntan que el cuidado ocurre directa e indirectamente, a favor de la plena restauración del cliente, incluyendo el ambiente que lo integra, de modo a mantenerse harmónico y equilibrado. Las intervenciones de la enfermera son en el sentido de mantener el ambiente en condiciones favorables de modo a tornalo promotor de los cuidados.The purpose of this qualitative research was to characterize the elements that constitute the environment of the Surgical Center and to analyze its implications for dynamic of care and nursing care. Based on the Environmental Theory

  2. La sostenibilidad en el currículo de las carreras de arquitectura: Implicaciones del concepto de sostenibilidad en el perfil profesional y el plan de estudios de las carreras de arquitectura en América Latina

    Directory of Open Access Journals (Sweden)

    Alexander González C.

    2012-06-01

    Full Text Available La formación y la práctica profesional de los arquitectos deben corresponder con las necesidades y tendencias sociales, económicas y ambientales de su contexto, a partir del desarrollo sostenible como marco de referencia. Esta condición es relevante en la comunidad latinoamericana, donde la formación en arquitectura es uno de los principales factores de oportunidad para la futura transformación del ambiente construido, mediante la definición de competencias científicas, técnicas y proyectuales orientadas al diseño sostenible. Un análisis del currículo oficial de 595 programas de arquitectura en 19 países de América Latina, permitió determinar el panorama actual de integración de la sostenibilidad en la formación profesional de los arquitectos. En el proceso se clasifican las carreras de arquitectura en cuatro categorías, de acuerdo con el nivel de integración de la sostenibilidad en su currículo oficial: integración nula, integración adicional, integración teórica e integración práctica en los talleres de proyecto. Los resultados muestran que sólo el 7% de los programas de arquitectura ofrecidos actualmente en América latina, declaran en su currículo oficial de forma explícita, la formación de competencias prácticas en diseño sostenible de sus egresados, 45% de los programas se orientan a la integración por contenidos teóricos y el 48% restante no declaran integrar la sostenibilidad en la formación de sus arquitectos.

  3. Estudio, en alumnos adolescentes, del uso de inferencias de razonamiento verbal que indican causalidad : implicaciones en la formación inicial de los profesores de Educación Secundaria

    OpenAIRE

    Macias Gómez, Escolástica

    1995-01-01

    En el aprendizaje escolar se utiliza esencialmente el lenguaje como herramienta de expresión, elaboración y valoración de los conocimientos. De aquí que en este trabajo de investigación se pretenda indagar sobre algunas situaciones en las que se ponga en evidencia la importancia que tiene en el aula el uso correcto de la lengua. Desde la consideración del razonamiento de los alumnos adolescentes en el uso que hacen de expresiones que conllevan a realizar inferencias de razonamiento deductivo,...

  4. IMPLICACIONES ÉTICAS Y SOCIALES DE LA INTRODUCCIÓN DE LA VACUNA CONTRA EL VIRUS DEL PAPILOMA HUMANO EN MÉXICO: REFLEXIONES SOBRE UNA PROPUESTA DE INTERVENCIÓN

    OpenAIRE

    Prieto de la Rosa,Alejandra; Gutiérrez Delgado,Cristina; Feinholz Klip,Dafna; Morales González,Gisela; Witlen,Renee

    2008-01-01

    El objetivo de este trabajo es identificar aspectos éticos y sociales relacionados con la introducción de la vacuna contra el virus del papiloma humano (VPH) en México para una decisión informada y justa que considere no sólo los aspectos financieros. De acuerdo con la información sobre eficiencia y costo de la vacuna, su introducción al sistema público mexicano puede acarrear consecuencias no previstas para las participantes y para toda la sociedad, por lo que debe examinarse en el contexto ...

  5. Distant metastatic retinoblastoma without central nervous system involvement

    Directory of Open Access Journals (Sweden)

    Mohammad Javed Ali

    2013-01-01

    Full Text Available Retinoblastoma is the most common intraocular malignancy in children, with a reported incidence ranging from 1 in 15,000 to 1 in 18,000 live births. Metastatic retinoblastoma is rare in developed countries, with a reported range from 4.8% in the United States to 5.8% in the United Kingdom. However, the frequency reported from developing countries varies from 9 to 11% at presentation. The mortality is very high owing to late presentations, delayed diagnosis compounded by socio-economic factors. The management of metastatic retinoblastoma is evolving, but it is still a challenge in pediatric oncology. We present a case of an extensive skeletal metastasis that initially presented as a massive orbital retinoblastoma.

  6. Molecular-genetic analysis of two cases with retinoblastoma ...

    Indian Academy of Sciences (India)

    Unknown

    Effective counselling and management of retinoblastoma families using genetic information is presently practised in many parts of ... to chromosomal deletion, single-nucleotide alteration, microdeletion, loss ... informed consent of the parent.

  7. A Técnica Esportiva como Construção Cultural: implicações para a pedagogia do esporte Sport Technique as a Cultural Construction: Implications to Sport Pedagogy La técnica deportiva como construcción cultural: implicaciones hacia la pedagogía del deporte

    Directory of Open Access Journals (Sweden)

    2008-03-01

    Full Text Available

    O texto discute a técnica esportiva a partir de alguns referenciais das ciências sociais e humanas, fazendo um contraponto ao conceito tradicional de técnica utilizado pela área de Educação Física e Esporte, cuja base teórica é composta primordialmente por contribuições das ciências da natureza. Considerando a técnica como o conjunto de modos de fazer e a tática como as razões do fazer, o texto trata das implicações para a pedagogia do esporte, propondo o ensino da cultura esportiva de forma mais democrática, singular e autoral, respeitando as especificidades culturais e as constantes ressignificações do esporte.

    PALAVRAS-CHAVE: esporte - cultura esportiva - pedagogia do esporte - técnica esportiva

    This text discusses technique in sport based on references from the social and human sciences and it questions the traditional concept of technique used in the field of physical education and sports, which is taken primarily from contributions of the natural sciences. By considering technique as a set of procedures to do something, and tactics as the reasons for doing something, the text discusses its possible implications for sport pedagogy and argues for a teaching of sport culture that is more democratic, singular, and authoral, with a respect for cultural specificities and for the constant resignifications of sports.


    Keywords: sport – sport culture – sport pedagogy – sport technique.

    El texto discute la técnica deportiva partiendo de algunos referenciales de las ciencias sociales y humanas, y hace un contrapunto al concepto tradicional de técnica utilizado por el área de Educación Física y Deporte, cuya base teórica se compone primordialmente por contribuciones de las ciencias naturales. Considerando la técnica como el conjunto de maneras de hacer, y la táctica como las razones de hacer, el texto trata de las implicaciones para la pedagogía deportiva, y propone la ense

  8. Dinámica estacional de la abundancia de piquituerto común Loxia curvirostra L., 1756 en dos localidades del Pirineo Navarro e implicaciones para su seguimiento mediante anillamiento.

    Directory of Open Access Journals (Sweden)

    Daniel Alonso

    2017-01-01

    Full Text Available Las estaciones de anillamiento de aves de esfuerzo constante realizan un papel clave en el seguimiento de poblaciones a largo plazo. El periodo de muestreo de este tipo de estaciones se ajusta a la época de nidificación de las especies más abundantes, en el caso de España entre los meses de abril-mayo y agosto. En consecuencia, aquellas especies cuya reproducción no coincida con la del grueso de especies quedan, invariablemente, poco o indebidamente representadas en este tipo de programas de seguimiento. Lo mismo ocurre con especies que, debido a su comportamiento, requieren de técnicas de muestreo especiales o específicas para su monitorización. Ejemplo de tales excepciones sería el piquituerto común Loxia curvirostra, L. 1758. En este artículo se describe el patrón estacional de la abundancia de piquituertos en dos localidades del Pirineo Navarro empleando datos de anillamiento obtenidos durante un periodo de 22 años. Los patrones observados fueron homogéneos entre ambos puntos de muestreo. Nuestros resultados sugieren que el promedio de capturas entre los meses de enero y abril podría utilizarse como un índice de la abundancia de individuos adultos durante el periodo de cría en el Pirineo Occidental.

  9. Craniospinal Irradiation for Trilateral Retinoblastoma Following Ocular Irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Marks, Lawrence B.; Bentel, Gunilla; Sherouse, George W.; Spencer, David P.; Light, Kim

    2015-01-15

    A case study is presented. Craniospinal radiotherapy and a three-field pineal boost for trilateral retinoblastoma were delivered to a patient previously irradiated for ocular retinoblastoma. The availability of CT-based three-dimensional treatment planning provided the capability of identifying the previously irradiated volume as a three-dimensional anatomic structure and of designing a highly customized set of treatment beams that minimized reirradiation of that volume.

  10. Scleral buckling for retinal detachment in patients with retinoblastoma

    International Nuclear Information System (INIS)

    Buzney, S.M.; Pruett, R.C.; Regan, C.D.; Walton, D.S.; Smith, T.R.

    1984-01-01

    Three children (two girls and one boy) with bilateral retinoblastoma each developed a presumed rhegmatogenous retinal detachment in one eye. All three eyes had previously received radiation and cryotherapy. In each case the retinal detachment responded promptly to conventional surgical methods via scleral buckling in the area of treated retinoblastoma and presumed retinal break. All three eyes have retained useful vision for follow-up periods of 3.5 to 12 years

  11. Scleral buckling for retinal detachment in patients with retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Buzney, S.M.; Pruett, R.C.; Regan, C.D.; Walton, D.S.; Smith, T.R.

    1984-10-15

    Three children (two girls and one boy) with bilateral retinoblastoma each developed a presumed rhegmatogenous retinal detachment in one eye. All three eyes had previously received radiation and cryotherapy. In each case the retinal detachment responded promptly to conventional surgical methods via scleral buckling in the area of treated retinoblastoma and presumed retinal break. All three eyes have retained useful vision for follow-up periods of 3.5 to 12 years.

  12. Travestis e transexuais profissionais do sexo: implicações da Psicologia Travestis y transexuales profesionales del sexo: implicaciones de la Psicología Sex profissional travestites and trans - sexuals: implications in Psychology

    Directory of Open Access Journals (Sweden)

    Carmem Regina Giongo

    2012-01-01

    Full Text Available Este trabalho teve como objetivo analisar e discutir as demandas de travestis e transexuais profissionais do sexo com relação à saúde mental. Participaram do estudo 10 travestis e 2 transexuais, e todas se declararam profissionais do sexo. A coleta de dados se deu por meio de grupos focais, sendo a análise dos dados qualitativa pautada na análise de conteúdo. Os resultados da pesquisa apontaram uma fragilidade na rede de apoio social e afetiva dos participantes, representada pelo sentimento de abandono e de solidão. Os resultados evidenciaram a necessidade de implementação de políticas públicas e de intervenções no âmbito da saúde mental.Este trabajo tuvo como objetivo analizar y discutir las demandas de travestis y transexuales profesionales del sexo con relación a la salud mental. Participaron del estudio 10 travestis y 2 transexuales, y todas se declararon profesionales del sexo. La recogida de datos se dio por medio de grupos focales, siendo el análisis de los datos cualitativo pautado en el análisis de contenido. Los resultados de la investigación apuntaron una fragilidad en la red de apoyo social y afectivo de los participantes, representada por el sentimiento de abandono y de soledad. Los resultados evidenciaron la necesidad de implementación de políticas públicas y de intervenciones en el ámbito de la salud mental.This work had as a goal to analyze and discuss the demands of sex professionals, as transvestites and trans-sexual in relation to mental health. Ten transvestites and two trans-sexuals participated in this study. All the participants declared themselves sex professionals. The collection of data happened through focal groups, being the qualitative analysis of the data ruled in the content analysis. The results of the survey pointed to a fragility in the social and affectionate support of the participants, represented by the feeling of desertion and solitude. The results showed the necessity of the

  13. Efectos del envejecimiento en las capacidades físicas: implicaciones en las recomendaciones de ejercicio físico en personas mayores. (Effects of aging on physical fitness: implications in the recommendations of physical activity for older adults.

    Directory of Open Access Journals (Sweden)

    Ana Carbonell Baeza

    2009-10-01

    Full Text Available Resumen El envejecimiento produce una involución de las capacidades físicas que origina un deterioro del estado físico y una reducción de la funcionalidad personal. Conforme avanza la edad se produce una pérdida de fuerza, un descenso de la capacidad aeróbica y una reducción progresiva no lineal y específica por articulación y movimiento articular de la flexibilidad. Además, los desórdenes de equilibrio son frecuentes en las personas mayores, por lo que el trabajo de flexibilidad y equilibrio, secundario en personas adultas, cobra especial protagonismo en las personas mayores. Asociada a la edad se producen modificaciones sustanciales de la composición corporal, con una disminución de la masa libre de grasa, que condiciona un descenso del gasto metabólico basal y un incremento de la masa grasa. La práctica de actividad física ha demostrado ser una herramienta eficaz para atenuar o retardar el envejecimiento, pero sólo si dicho ejercicio es practicado de forma regular y con la intensidad adecuada, contribuirá a mejorar la capacidad funcional global del organismo. Las diferentes recomendaciones de actividad física para personas mayores publicadas hasta la fecha, determinan dichos criterios mínimos de volumen e intensidad, por lo que se deben tener presentes a la hora de realizar una prescripción de ejercicio físico a una persona mayor.AbstractAging process is associated with progressive declines in physical fitness and functionality. Across age, there is a lost of strength, aerobic capacity (Vo2max and a progressive but not linear decreasing of specific joint mobility. Furthermore, balance disorders are common in older people. In addition, the flexibility and balance training, which is secondary in adult people, it is of special relevance in old people. Age-related changes occur in body composition: fat free mass decreases and it determines lower energy expenditure and consequent increase in fat mass. Physical activity has

  14. El concepto de materialidad: implicaciones para gerentes e inversionistas

    Directory of Open Access Journals (Sweden)

    Ahmad Hussein Juma’h

    2014-01-01

    Full Text Available Se discuten las implicaciones de la materialidad de la información financiera sobre “manejo de los ingresos”. Implica la descripción y el análisis del contenido de la Codificación de Normas Contables™. Las perspectivas profesionales fueron utilizadas para confirmar la ausencia de directrices de importancia relativa en los Principios de Contabilidad Generalmente Aceptados (en inglés, PCGA de los EE. UU. Los términos “materialidad”, “significancia” e “importancia” fueron usados para determinar la inclusión de materialidad en las codificaciones. Las principales conclusiones indican que, primero, los factores determinantes y las motivaciones internas y externas influyen en las prácticas de “manejos de ganancias” y, segundo, los PCGA de EE. UU. no cuentan con directrices bien definidas para aplicar la materialidad en la toma de decisiones.

  15. Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma.

    Science.gov (United States)

    Pritchard, Eleanor M; Dyer, Michael A; Guy, R Kiplin

    2016-01-01

    While mortality is low for intraocular retinoblastoma patients in the developed world who receive aggressive multimodal therapy, partial or full loss of vision occurs in approximately 50% of patients with advanced bilateral retinoblastoma. Therapies that preserve vision and reduce late effects are needed. Because clinical trials for retinoblastoma are difficult due to the young age of the patient population and relative rarity of the disease, robust preclinical testing of new therapies is critical. The last decade has seen advances towards identifying new therapies including the development of animal models of retinoblastoma for preclinical testing, progress in local drug delivery to reach intraocular targets, and improved understanding of the underlying biological mechanisms that give rise to retinoblastoma. This review discusses advances in these areas, with a focus on discovery and development of small molecules for the treatment of retinoblastoma, including novel targeted therapeutics such as inhibitors of the MDMX-p53 interaction (nutlin-3a), histone deacetylase (HDAC) inhibitors, and spleen tyrosine kinase (SYK) inhibitors.

  16. Retinoblastoma: concerning its initiation and treatment

    Directory of Open Access Journals (Sweden)

    Ying-Ping Deng

    2013-06-01

    Full Text Available Retinoblastoma (RB is the most common intraocular cancer of infancy and childhood. This cancer is initiated by mutation on RB1, the tumor suppressor gene that is responsible for the regulation of both cell cycle and gnome stability in retinal cells. Patients with a constitutional mutation on RB1 can be inherited. RB occurs approximately 1 in every 15 000-20 000 live births. The worldwide mortality for this cancer is about 5%-11%. However, this rate rises to about 40%-70% in developing countries due to a delay in diagnosis. A wide variety of options are available for the treatment, but often a combination of therapies is adopted to optimize individualized care.

  17. Cobalt60 plaques in recurrent retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Fass, D.; McCormick, B.; Abramson, D.; Ellsworth, R. (Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, NY, NY (USA))

    1991-08-01

    Cobalt60 plaque irradiation is one treatment option for patients with recurrent retinoblastoma following conventional external beam irradiation (ERT). Tumorocidal doses can be delivered without excessive risk of normal tissue injury. In patients not considered candidates for xenon arc or cryotherapy, 60Co is an alternative to enucleation. Between 1968 and 1987, 85 patients were treated with 60Co plaques, 72 of whom had failed prior ERT. Age at diagnosis ranged from 1 week to 4 years. There are 37 males and 35 females. Seventy-one patients had bilateral disease and one had unilateral. Three patients had both eyes plaqued. Prior ERT ranged from 30 to 70 Gy (mean 4200 Gy). Time from initial therapy to failure ranged from 13 to 60 months. Cobalt plaques of 10 mm, 15 mm, or 10 {times} 15 mm were used depending on tumor size and location. Dose prescribed to the apex of the tumor ranged from 30 to 50 Gy (median 40 Gy) given over 3 to 8 days. Twelve patients had two plaque applications; three patients had three plaque applications. All patients were followed with routine ophthalmoscopic examinations. Follow-up ranged from 2 to 22 years (mean 8.7). Seven patients died of metastatic disease; 10 patients developed non-ocular second tumors. Thirty patients required enucleation. Twenty-two patients had clear tumor progression, two patients had radiation complications, and six patients had a combination of tumor growth and complications. Cobalt60 can salvage eyes in retinoblastoma patients failing ERT. Currently, the authors are using I125 in an attempt to spare normal ocular tissue and reduce subsequent complications.

  18. Cobalt60 plaques in recurrent retinoblastoma

    International Nuclear Information System (INIS)

    Fass, D.; McCormick, B.; Abramson, D.; Ellsworth, R.

    1991-01-01

    Cobalt60 plaque irradiation is one treatment option for patients with recurrent retinoblastoma following conventional external beam irradiation (ERT). Tumorocidal doses can be delivered without excessive risk of normal tissue injury. In patients not considered candidates for xenon arc or cryotherapy, 60Co is an alternative to enucleation. Between 1968 and 1987, 85 patients were treated with 60Co plaques, 72 of whom had failed prior ERT. Age at diagnosis ranged from 1 week to 4 years. There are 37 males and 35 females. Seventy-one patients had bilateral disease and one had unilateral. Three patients had both eyes plaqued. Prior ERT ranged from 30 to 70 Gy (mean 4200 Gy). Time from initial therapy to failure ranged from 13 to 60 months. Cobalt plaques of 10 mm, 15 mm, or 10 x 15 mm were used depending on tumor size and location. Dose prescribed to the apex of the tumor ranged from 30 to 50 Gy (median 40 Gy) given over 3 to 8 days. Twelve patients had two plaque applications; three patients had three plaque applications. All patients were followed with routine ophthalmoscopic examinations. Follow-up ranged from 2 to 22 years (mean 8.7). Seven patients died of metastatic disease; 10 patients developed non-ocular second tumors. Thirty patients required enucleation. Twenty-two patients had clear tumor progression, two patients had radiation complications, and six patients had a combination of tumor growth and complications. Cobalt60 can salvage eyes in retinoblastoma patients failing ERT. Currently, the authors are using I125 in an attempt to spare normal ocular tissue and reduce subsequent complications

  19. Descripción histológica del ojo de Panaque nigrolineatus (Siluriformes: Loricariidae y sus implicaciones ecomorfológicas Histological structure of the eye of Panaque nigrolineatus (Siluriformes: Loricariidae, ecomorphological implications

    Directory of Open Access Journals (Sweden)

    SHERYLL CORCHUELO

    2012-06-01

    Full Text Available La cucha real (Panaque nigrolineatus es endémica de las cuencas del Orinoco y Amazonas. La información relacionada con el sistema visual de esta especie es muy escasa, a pesar de ser un sentido fundamental en la interacción del individuo con su ambiente. Los especímenes se clasificaron en dos grupos en base a su tamano corporal: pequenos (longitud estándar (media ± DE de 5.92 ± 1.43 cm y peso promedio de 8.50 ± 6.8 g y grandes (longitud estándar (media ± DE de 15.9 ± 0.69 cm y peso promedio de 142.48 ± 18.71 g. En los ejemplares pequenos, el ojo presentó una morfología redondeada, y en los de mayor tamano presentó una morfología ligeramente alargada. Se obtuvieron cortes histológicos de 7 μηι que fueron coloreados con las técnicas H&E y Orceína. El tamano relativo del ojo fue mayor en los ejemplares pequenos (6.46 % que en los de mayor tamano (4.55 %. El espesor de la córnea de los grupos evaluados, presentó variaciones morfométricas significativas, entre su espesor central y periférico. La esclera presentó tejido conectivo denso. Los individuos de mayor tamano corporal tienen una esclera significativamente más gruesa tanto en la región lateral como en la región posterior. Algo similar ocurre con el espesor del iris. La pupila presentó morfología omega. En el cristalino fueron evidenciadas interdigitaciones celulares ubicadas en las regiones laterales. La retina de P. nigrolineatus está compuesta por siete capas. No existen diferencias significativas entre el espesor de la retina de los dos grupos evaluados de P! nigrolineatus. Se observaron de 10 a 12 papilas del nervio óptico en la retina de P. nigrolineatus cuyo diámetro oscila entre 24.57 y 131.90 μηι. Teniendo en cuenta el análisis histológico y morfométrico del ojo de P. nigrolineatus, esta especie presenta adaptaciones orientadas a suplir los requerimientos visuales de organismos bentónicos que habitan ecosistemas con cuerpos de agua turbios, de

  20. ¿Cómo afecta la unidad espacial a la visualización y modelado del área de mercado con sistemas de información geográfica? Implicaciones para el geomarketing

    Directory of Open Access Journals (Sweden)

    Moreno Jiménez, Antonio

    2004-12-01

    Full Text Available In geomarketing, mapping and modelling market areas, using GIS and statistical techniques, are common tasks when approaching spatial decision problems by retail and service firms. To this end, concepts and data concerning to demand (e.g. penetration rate, market share, sales per customer, etc., referred to spatial units, are used. Based on previous evidence on the so-called modifiable spatial unit problem, in this paper it is explored how the cartographic representation and modelling of market area are affected when different spatial units are used. The conclusions allow to apprehend the scope of such effects, provide suggestions for a more thoughtful choice of spatial units when GIS are applied, and, lastly, help to improve decision making on new store location through the analog approach.

    Dentro del geomarketing, y en aras de solventar problemas de decisión espacial por parte de las empresas comerciales y de servicios a escala local, una de las tareas comunes estriba en cartografiar y modelar las áreas de mercado, combinando la tecnología SIG con técnicas estadísticas. A tal fin se parte de conceptos y datos relativos a la demanda (por ejemplo, tasa de penetración, cuota de mercado, gasto per cápita, etc. referidos a determinadas unidades espaciales. Ante las evidencias que estudios previos han obtenido sobre el llamado problema de la unidad espacial modificable (PUEM, en este trabajo se investiga cómo se ve afectada la representación y modelado del área mercado cuando se adoptan conjuntos distintos de unidades espaciales. Las conclusiones permiten valorar el alcance de dichos efectos, proporcionan recomendaciones para elegir de manera más atinada las unidades espaciales a la hora de aplicar los SIG y coadyuvan, en última instancia, a mejorar la toma de decisiones sobre localización de nuevos establecimientos mediante el método de la analogía.

  1. Influencia de la reacticivad cardiovascular sobre la discriminación del latido cardíaco: implicaciones en la detección precoz de síntomas

    Directory of Open Access Journals (Sweden)

    P. QUIRÓS

    2004-01-01

    Full Text Available Una respuesta metabólicamente exagerada en personas jóvenes ante situaciones de estrés es considerada como un marcador de riesgo de una futura hipertensión. Asimismo, los autores que investigan las diferencias individuales en la percepción de síntomas consideran que una mayor percepción visceral puede estar asociada con un mejor reconocimiento de síntomas en aquellas personas que padecen enfermedades crónicas con manifestaciones sutiles o vagas, como por ejemplo, la hipertensión esencial. En consecuencia, este estudio examina la relación entre reactividad cardiovascular y percepción del latido cardiaco. Una muestra de 42 sujetos participó en dos sesiones experimentales: en la primera de ellas realizaron una tarea evocadora de reactividad cardiovascular, en la segunda una tarea de discriminación del latido cardiaco mediante el método de los estímulos constantes. La reactividad cardiovascular fue definida como la diferencia en puntuación entre una condición de línea base y la condición de tarea. Las variables fisiológicas en las que se midió la reactividad cardiovascular fueron el periodo cardiaco (PC, la presión arterial sistólica (PAS y la presión arterial diastólica (PAD. Si bien en el total de la muestra se encontraron diferencias significativas en todas las variables fisiológicas entre la condición de línea base y la condición de tarea, el grupo que logró discriminar el latido cardiaco no mostró una reactividad cardiovascular más elevada que el grupo que no logró discriminarlo, al menos en cuanto al periodo cardiaco y a la presión arterial se refiere.

  2. Implications of the Central America-Dominican Republic-Free Trade Agreement for the nutrition transition in Central America Implicaciones del Tratado de Libre Comercio entre Centroamérica y República Dominicana sobre la transición alimentaria en Centroamérica

    Directory of Open Access Journals (Sweden)

    Corinna Hawkes

    2008-11-01

    relacionados con la transición alimentaria, la obesidad y las enfermedades crónicas asociadas con la alimentación. MÉTODOS: Se examinó el TLCCA-RD para identificar las medidas que podrían afectar a la disponibilidad de alimentos y los precios al consumidor. RESULTADOS: El TLCCA-RD contiene acuerdos sobre tarifas, cuotas arancelarias y regulaciones sanitarias y fitosanitarias con implicaciones directas sobre la disponibilidad y los precios de varios alimentos. Los acuerdos sobre inversión, servicios y derechos de propiedad intelectual son también importantes debido a que crean un ambiente de negocios más favorable a inversiones a largo plazo de empresas transnacionales de la industria alimentaria. La liberalización del comercio por el TLCCA-RD podría incrementar la disponibilidad y reducir los precios relativos de dos grupos de alimentos asociados con la transición alimentaria: las carnes y los alimentos procesados. Esto podría ser resultado directo del aumento en las importaciones desde los Estados Unidos de América y de la producción de las compañías estadounidenses basadas en Centroamérica, y resultado indirecto del aumento en la producción local de carne (por la mayor disponibilidad de alimentos más baratos para animales y el aumento en la producción de alimentos procesados por compañías locales (debido a un ambiente comercial más competitivo. CONCLUSIONES: El TLCCA-RD podría reforzar la transición alimentaria en Centroamérica al elevar el consumo de carne, alimentos muy procesados y alimentos nuevos no tradicionales. La comunidad de salud pública debe estar más atenta a las implicaciones de los acuerdos comerciales sobre la salud alimentaria. Los Gobiernos y las entidades relacionadas con el tema deben evaluar la coherencia entre los cambios propiciados por los acuerdos comerciales específicos y las políticas alimentarias y dietéticas nacionales.

  3. Alcohol consumption and burden of disease in the Americas: implications for alcohol policy El consumo de alcohol y la carga de morbilidad en el continente americano: implicaciones para las políticas de control del consumo de alcohol

    Directory of Open Access Journals (Sweden)

    Jürgen Rehm

    2005-11-01

    alcohol. MÉTODOS: Dos aspectos de la exposición al alcohol se abarcaron en este análisis de datos secundarios: el volumen promedio de alcohol consumido y los hábitos de consumo. Se establecieron dos parámetros de interés principales: la mortalidad (número de defunciones y los años de vida perdidos, calculados en función de la presencia de discapacidad (DALY (es decir, los años perdidos como resultado de una muerte temprana y de la presencia de discapacidad. Se hicieron cálculos separados en función del sexo, el grupo de edad y la región de la Organización Mundial de la Salud. RESULTADOS: A pesar de que se observan diferencias regionales, el consumo de alcohol en el continente americano fue, en promedio, más de 50% mayor que en el mundo en general. Se advirtió la tendencia a beber en exceso de manera errática. El consumo de alcohol explica una elevada fracción de la carga de morbilidad: 4,8% de todas las muertes y 9,7% de todos los DALYs perdidos en 2000 se atribuyeron al consumo de alcohol, y la mayor parte de esta carga de morbilidad se observó en países que no pertenecen a América del Norte. Traumatismos intencionados y no intencionados fueron causa de 59,8% de todas las defunciones relacionadas con el consumo de alcohol y de 38,4% de la carga de morbilidad correspondiente. De todos los factores de riesgo comparados en este trabajo, el alcohol aportó la mayor proporción del riesgo, seguido del tabaco. CONCLUSIONES: Se deben llevar a cabo intervenciones para reducir la elevada carga de morbilidad relacionada con el alcohol en el continente americano. Dada la estructura epidemiológica de esta carga, la prevención de traumatismos -no solo los provocados por accidentes de tránsito sino otros también-, así como la provisión de tratamientos adecuados, debe ser parte importante de todo plan general dirigido a reducir la carga sanitaria asociada con el consumo de alcohol.

  4. El distrés psicológico y abuso de drogas en pacientes en centros de tratamiento del gran Valparaíso - Chile: implicaciones para las políticas y los programas

    Directory of Open Access Journals (Sweden)

    Liliana Basso Musso

    2012-01-01

    Full Text Available El objetivo fue determinar la prevalencia de comorbilidad entre distrés psicológico y abuso/dependencia de drogas en pacientes en centros de tratamiento. Este estudio epidemiológico, multicéntrico, de corte transversal, realizado en 107 pacientes mayor es de 18 años, en tratamiento por abuso/dependencia de drogas, en centros de tratamiento de Valparaíso, Chile, mostró además otros factores involucrados como: aspectos sociodemográficos, funcionalidad familiar, características del consumo de drogas y aspectos de la atención otorgada. Para recolección de datos se usó el EULAC (Instrumento para diagnostico rápido de situación de tratamiento para problemas por consumo de drogas en el ámbito local el K 10 y Apgar familiar. Resultados: 48.6% presentaron distrés psicológico; 88.8% refirieron satisfacción por el tratamiento actual. 66.4% pertenece a una familia normo funcional. Los resultados obtenidos permitirán mejorar las intervenciones en pacientes que están en tratamiento y rehabilitación en los centros de tratamiento.

  5. Mortalidad evitable en los estados de la frontera del norte de México: posibles implicaciones sociales y para los servicios de salud / Avoidable mortality in the border states of northern Mexico: potential implications for social determinants and health services

    Directory of Open Access Journals (Sweden)

    Ana M. López J.

    2015-09-01

    Full Text Available RESUMEN Objetivo: analizar la mortalidad evitable en los estados de la frontera del norte de México entre 1998 y 2007 para indirectamente evaluar la calidad de los servicios de salud en la región. Metodología: se analizó la información sobre mortalidad del Sistema Nacional de Información en Salud (sinais. La unidad de análisis fue la causa básica de la defunción codificada según la décima revisión de la CIE. La mortalidad evitable fue clasificada según el catálogo de causas de muerte propuesto por Gómez. Se hizo un análisis exploratorio de la relación entre la mortalidad evitable y la derechohabiencia y el nivel socioeconómico de los municipios correspondientes a las muertes. Resultados: la tasa de mortalidad evitable global fue de 350,2 muertes por mil habitantes en la región. La mortalidad evitable por diagnóstico y tratamiento médico precoz, violencia y VIH/SIDA tuvo tasas de 223, 60 y 5 por mil habitantes, respectivamente, presentando variaciones de magnitud, sociodemográficas y por derechohabiencia entre estados. Discusión y conclusiones: las poblaciones de los estados de la frontera norte de México se caracterizan por tener una dinámica sociodemográfica y de los servicios de salud muy intensa. Los resultados sugieren que el sistema de salud está siendo rebasado en su respuesta a una alta frecuencia de enfermedades no transmisibles. En el aspecto social existen condiciones estructurales en México que favorecen la presencia de narcotráfico y su consecuente causa de violencia y consumo de drogas ilegales que podrían estar relacionadas con la frecuencia de muertes violentas y en forma subsidiaria con las causadas por el VIH/SIDA. / ABSTRACT Objective: to analyze avoidable mortality between 1998 and 2007 in the border states of Northern Mexico to evaluate, indirectly, the quality of the region's health care services. Methodology: the information on mortality provided by the National Health Information System

  6. Seguridad en el mar, algunas implicaciones de los códigos IGS y PBIB.

    Directory of Open Access Journals (Sweden)

    José Vicente Guzmán Escobar

    2007-12-01

    Full Text Available La expedición del Código Internacional de Gestión de la Seguridad Marítima (Código IGS y del Código de Protección de Buques e Instalaciones Portuarias (Código PBIB, en el contexto del Convenio SOLAS, tiene especiales implicaciones legales en diferentes figuras del derecho marítimo internacional, tales como la limitación de responsabilidad de los armadores de buques por reclamaciones marítimas, la limitación de responsabilidad de los armadores por contaminación por derrames de hidrocarburos, la limitación de responsabilidad del transportador marítimo de mercancías, la obligación del armador y del transportador marítimo en relación con la navegabilidad del buque, los contratos de fletamento y las coberturas de los Clubes de Protección e Indemnización. El presente artículo hace una descripción de las posibles consecuencias jurídicas que los citados códigos internacionales pueden tener respecto de cada una de estas instituciones y contratos.

  7. Seguridad en el mar, algunas implicaciones de los códigos IGS y PBIB.

    Directory of Open Access Journals (Sweden)

    José Vicente Guzmán Escobar

    2007-01-01

    Full Text Available La expedición del Código Internacional de Gestión de la Seguridad Marítima (Código IGS y del Código de Protección de Buques e Instalaciones Portuarias (Código PBIB, en el contexto del Convenio SOLAS, tiene especiales implicaciones legales en diferentes figuras del derecho marítimo internacional, tales como la limitación de responsabilidad de los armadores de buques por reclamaciones marítimas, la limitación de responsabilidad de los armadores por contaminación por derrames de hidrocarburos, la limitación de responsabilidad del transportador marítimo de mercancías, la obligación del armador y del transportador marítimo en relación con la navegabilidad del buque, los contratos de fletamento y las coberturas de los Clubes de Protección e Indemnización. El presente artículo hace una descripción de las posibles consecuencias jurídicas que los citados códigos internacionales pueden tener respecto de cada una de estas instituciones y contratos.

  8. A study on the toxicity of three radiosensitizers on retinoblastoma cells by MTT assay

    International Nuclear Information System (INIS)

    Yi Xianjin; Jin Yizun; Ding Li; Ni Zhou; Wang Wenji

    1994-01-01

    The toxicity of three radiosensitizers BSO, CM and RSU-1069 on retinoblastoma cells was determined and the efficiency of in vitro MTT assay on drug-screening for retinoblastoma was also evaluated. The results showed that the MTT assay is very useful. The toxicity of radiosensitizers on retinoblastoma cells is dependent on cell line characteristics, drug concentration and time of exposure to it

  9. Athletes and sports teams as complex adaptive system: A review of implications for learning design. [Atletas y equipos deportivos como sistemas adaptativos complejos: Una revision de las Implicaciones para el diseño del aprendizaje].

    Directory of Open Access Journals (Sweden)

    Keith Davids

    2015-01-01

    coordinación y la capacidad de utilizar affordances, que subyacen en el desempeño y el aprendizaje en deportes individuales y en equipo. La discusión se centra sobre cómo los principios fundamentales de la dinámica ecológica informan nuestra comprensión del aprendizaje y la transferencia, y su impacto en el diseño de tareas prácticas en los programas de desarrollo deportivo. Para apoyar este análisis, se presentan los datos de la investigación sobre el desempeño de los atletas de élite y de desarrollo en los deportes individuales y de equipo para destacar importantes principios de diseño de aprendizaje desde una perspectiva dinámica ecológica.

  10. Design and Implementation of the Retinoblastoma Collaborative Laboratory.

    Science.gov (United States)

    Qaiser, Seemi; Limo, Alice; Gichana, Josiah; Kimani, Kahaki; Githanga, Jessie; Waweru, Wairimu; Dimba, Elizabeth A O; Dimaras, Helen

    2017-01-01

    The purpose of this work was to describe the design and implementation of a digital pathology laboratory, the Retinoblastoma Collaborative Laboratory (RbCoLab) in Kenya. The RbCoLab is a central lab in Nairobi that receives retinoblastoma specimens from all over Kenya. Specimens were processed using evidence-based standard operating procedures. Images were produced by a digital scanner, and pathology reports were disseminated online. The lab implemented standard operating procedures aimed at improving the accuracy, completeness, and timeliness of pathology reports, enhancing the care of Kenyan retinoblastoma patients. Integration of digital technology to support pathology services supported knowledge transfer and skills transfer. A bidirectional educational network of local pathologists and other clinicians in the circle of care of the patients emerged and served to emphasize the clinical importance of cancer pathology at multiple levels of care. A 'Robin Hood' business model of health care service delivery was developed to support sustainability and scale-up of cancer pathology services. The application of evidence-based protocols, comprehensive training, and collaboration were essential to bring improvements to the care of retinoblastoma patients in Kenya. When embraced as an integrated component of retinoblastoma care, digital pathology offers the opportunity for frequent connection and consultation for development of expertise over time.

  11. Socioeconomic and psychological impact of treatment for unilateral intraocular retinoblastoma.

    Science.gov (United States)

    Soliman, S E; Dimaras, H; Souka, A A; Ashry, M H; Gallie, B L

    2015-06-01

    To identify the socioeconomic and psychosocial impacts of clinical treatment decisions for advanced unilateral intraocular retinoblastoma. Retrospective observational case series. institutional study at Alexandria Main University Hospital. records of 66 unilateral retinoblastoma cases treated from May 2005 to May 2013 were retrospectively reviewed. Sixty cases were eligible (International Intraocular Retinoblastoma Classification [IIRC] group C, D or E). two treatment groups were compared: enucleation vs. salvage treatment. Salvage treatment eyes were further subdivided based on IIRC group. Six socioeconomic parameters (financial burden, financial impact, psychological, social, medical and tumor impacts) were scored. Parameter scores ranged from 0 to 3, for overall score range 0 (no adverse impact) to 18 (severe adverse impact). derived Socioeconomic scores were correlated with treatment and outcomes. The enucleation group (28 eyes) had a median overall Socioeconomic score of 4/18, significantly lower than the salvage treatment group (32 eyes), median score 11/18 (PSocioeconomic score varied with IIRC group. Attempted eye salvage failed in 25 children, due to uncontrolled tumor (44%) and socioeconomic impact of cumulative therapies (56%). Treatment duration and Socioeconomic score were higher for the 5 children in the salvage treatment group who developed metastatic disease compared to those without metastasis (Psocioeconomic and psychosocial impacts of attempted ocular salvage for unilateral intraocular retinoblastoma are severe, in comparison to primary enucleation. Primary enucleation is a good treatment for unilateral retinoblastoma. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  12. Current Trends in the Management of Retinoblastoma

    Directory of Open Access Journals (Sweden)

    Hayyam Kıratlı

    2014-09-01

    Full Text Available Retinoblastoma is the most common primary intraocular malignant tumor of early childhood, and 95% of all cases are diagnosed before the age of 5 years. Tumors are evaluated and classified based on laterality, genetic features, the number, location and size of foci. Currently, systemic and intaarterial chemotherapy are the most commonly used management options worldwide. Group A tumors are treated with focal techniques including transpupillary thermotherapy, cryotherapy, or laser photocoagulation. Groups B and C tumors are managed with systemic chemotherapy and focal consolidation techniques. Group D lesions are best treated with systemic chemotherapy, subtenon carboplatin injection or external beam radiotherapy. Alternatively, groups B, C and D tumors can be primarily treated with intraarterial chemotherapy. Intravitreal melphalan injection can be an alternative treatment for eyes with recurrent or persistent vitreous seeding. Group E eyes are often enucleated, however, depending on the fellow eye, systemic or intraarterial chemotherapy may be administered. Systemic chemotherapy is also mandatory if high-risk histopathological features are found after enucleation. (Turk J Ophthalmol 2014; 44: Supplement 22-8

  13. Atraso diagnóstico do retinoblastoma Delayed diagnosis in retinoblastoma

    Directory of Open Access Journals (Sweden)

    Karla E. S. Rodrigues

    2004-12-01

    Full Text Available OBJETIVOS: Identificar os principais sinais e sintomas do retinoblastoma e determinar o tempo médio entre o início dos sintomas e o diagnóstico. MÉTODOS: Estudo retrospectivo, com revisão dos prontuários das crianças diagnosticadas com retinoblastoma entre janeiro de 1991 e junho de 2000 no Departamento de Pediatria do Hospital do Câncer de São Paulo. Análise estatística: teste t de Student, análise e variância, teste de Tukey-HSD (honest significant differences, teste de Levene, análise de regressão linear, curva ROC, regressão logística e análise de sobrevida pelo método de Kaplan-Meier. RESULTADOS: Foram revisados 327 prontuários, sendo 171 pacientes do sexo masculino. A idade média foi de 25 meses. Doença localizada foi verificada em 269 pacientes. Os sintomas mais freqüentes foram leucocoria (79%, estrabismo (10,7% e tumoração (3,4%. O tempo médio de queixa foi de 5,8 meses. Pacientes maiores de 2 anos de idade apresentaram maior tempo de queixa em relação aos lactentes (7,2 meses versus 4,7 meses; p = 0,001. Pacientes com estrabismo tiveram maior tempo de queixa (8,8 meses em comparação com pacientes com tumoração (2,3 meses ou leucocoria (5,6 meses (p = 0,014. Pacientes com doença metastática apresentaram maior tempo de queixa (10,6 meses; p OBJECTIVES: To identify the main symptoms of retinoblastoma and to determine the mean time between symptom onset and diagnosis (lag time. PATIENTS AND METHODS: We carried out a retrospective analysis of the patients diagnosed with retinoblastoma between January 1991 and June 2000, at the Pediatric Department of the Hospital do Câncer, São Paulo, Brazil. Statistical analyses performed were: Student's t test, ANOVA, Tukey-HSD test (honest significant differences, Levene's test, multiple regression, ROC curve, logistic regression, Kaplan-Meier, and log rank. RESULTS: 327 medical records (171 males were reviewed. The mean age was 25 months. Localized disease was

  14. Adenocarcinoma of the ethmoid following radiotherapy for bilateral retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Rowe, L.D.; Lane, R.; Snow, J.B. Jr.

    1980-01-01

    Adenocarcinoma of the ethmoid sinus is rare, representing only 4 to 8% of malignancies of the paranasal sinuses. An extraordinary case of papillary adenocarcinoma of the ethmoid sinus arising 30 years following high-dose radiotherapy for bilateral retinoblastoma is presented. Second fatal mesenchymal and epithelial primaries have been described in 8.5% of patients with bilateral retinoblastomas previously treated with radiotherapy; however, papillary adenocarcinoma arising within the paranasal sinuses has not been reported. Aggressive treatment including partial maxillectomy, radical pansinusectomy, radical neck dissection followed by regional radiotherapy and systemic chemotherapy failed to prevent the development of fatal hepatic metastases. The high incidence of second fatal primary neoplasms in patients with bilateral retinoblastomas receiving radiation suggests an innate susceptibility that may add to the risk of radiotherapy.

  15. Adenocarcinoma of the ethmoid following radiotherapy for bilateral retinoblastoma

    International Nuclear Information System (INIS)

    Rowe, L.D.; Lane, R.; Snow, J.B. Jr.

    1980-01-01

    Adenocarcinoma of the ethmoid sinus is rare, representing only 4 to 8% of malignancies of the paranasal sinuses. An extraordinary case of papillary adenocarcinoma of the ethmoid sinus arising 30 years following high-dose radiotherapy for bilateral retinoblastoma is presented. Second fatal mesenchymal and epithelial primaries have been described in 8.5% of patients with bilateral retinoblastomas previously treated with radiotherapy; however, papillary adenocarcinoma arising within the paranasal sinuses has not been reported. Aggressive treatment including partial maxillectomy, radical pansinusectomy, radical neck dissection followed by regional radiotherapy and systemic chemotherapy failed to prevent the development of fatal hepatic metastases. The high incidence of second fatal primary neoplasms in patients with bilateral retinoblastomas receiving radiation suggests an innate susceptibility that may add to the risk of radiotherapy

  16. Implicações do plano de desenvolvimento da educação para a formação de professores Implicaciones del plan de desarrollo de la educación para la formación de profesores Implications of the development plan of education for teacher training

    Directory of Open Access Journals (Sweden)

    Gisele Masson

    2012-03-01

    Full Text Available O artigo analisa as principais implicações do Plano de Desenvolvimento da Educação (PDE para a formação de professores. A pesquisa utilizou fontes bibliográficas e documentais e foi fundamentada na concepção materialista histórica e dialética. A proposta para a formação de professores presente no PDE é neopragmatista, pois reforça a importância da busca de instrumentos úteis para as demandas imediatas da prática profissional e não contribui para o desenvolvimento de uma sólida e ampla formação. A prioridade dada à formação de professores como solução para os resultados negativos obtidos pelo Índice de Desenvolvimento da Educação Básica (Ideb, em vez de um investimento financeiro adequado, revela a prioridade dada às condições subjetivas na resolução dos problemas educacionais.Este trabajo analiza las principales implicaciones del Plan de Desarrollo de la Educación (PDE, Brasil, para la formación continuada de profesores. La investigación utilizó fuentes bibliográficas y documentales y se basó en la concepción materialista histórica y dialéctica. La propuesta para la formación de profesores presente en el PDE es neopragmatista, pues corrobora la importancia de la búsqueda de instrumentos provechosos para las demandas inmediatas de la práctica profesional y no contribuye para el desarrollo de una sólida y amplia formación. La prioridad dada a la formación de profesores como solución de los resultados negativos del Índice de Desarrollo de la Educación Básica (Ideb en vez de un inversión financiera adecuada pone de manifiesto la prioridad dada a las condiciones subjetivas en la solución de los problemas educacionales.This paper analyzes the main implications of the Development Plan of Education (DPE for teacher training. The research used bibliographic and documentary sources and was based on historical and dialectical materialism concepts. The teacher training education proposal presented by

  17. Implicaciones metabólicas del consumo exesivo de fructosa

    OpenAIRE

    Esquivel-Solís, Viviana; Gómez-Salas, Georgina

    2007-01-01

    En los últimos años se ha dado un auge importante en la producción de alimentos endulzados con edulcorantes distintos a la sacarosa o azúcar de mesa, que por aportar menos calorías, son utilizados ya sea para perder peso o para mantener un peso saludable, o bien, para ofrecer opciones alimenticias a individuos que padecen de diabetes o intolerancia a la glucosa. Uno de los edulcorantes de mayor utilización es el jarabe de maíz alto en fructosa, el cual, en comparación con la sacarosa, tiene u...

  18. Competencias emocionales del alumnado de Magisterio: posibles implicaciones profesionales

    OpenAIRE

    Peñalva Vélez, Alicia; López-Goñi, José Javier; Landa González, Natalia

    2013-01-01

    El objetivo de este trabajo es explorar las competencias emocionales de alumnos de primer curso de Magisterio para posteriormente clasificarlos en función de diferentes perfiles competenciales. La muestra se compone de 110 alumnos que se agrupan mediante dos análisis de clúster. En el primero de ellos se los agrupa en función de sus competencias emocionales personales y en el segundo en función de sus competencias emocionales sociales. Los grupos obtenidos en cada modelo se comparan entre sí ...

  19. [Pathological profiles of retinoblastoma in Senegal].

    Science.gov (United States)

    Dial, C; Doh, K; Thiam, I; Ndoye Roth, P; Moreira, C; Woto-Gaye, G

    2016-11-01

    Describe the macroscopic and microscopic profiles of retinoblastoma (RB) in Senegal and correlate histological criteria with progression to establish severity factors. We realized a retrospective study over 10 years (January 2005-December 2014). Only patients (n=67) who underwent histological analysis of the enucleation specimen (n=68) were followed until the end of the study. The tumor measured an average of 3.8cm (2/4.5). Endophytic tumor development was observed in 55 cases (80.8%), exophytic in 6 cases (8.9%) and mixed in 7 cases (10.3%). Retinal detachment was present in 13 cases (19.2%). The RB was well differentiated in 11 cases (16.2%), moderately differentiated in 31 cases (45.6%) and undifferentiated in 26 cases. Optic nerve (ON) invasion was present in 18 cases (26.5%). The tumor was extraretinal in 37 cases (54.4%). The anterior chamber was invaded in 6 cases (8.8%). The global survival at 2 years was 84% and 70% at 5 years. On multivariate analysis, well differentiated tumors and stage pT1 were associated with remission. Retrolaminar ON invasion, massive choroidal invasion and stage pT3 were risk factors for recurrence. Poor tumor differentiation, invasion of the ON resection margin, tumor invasion through the sclera, and stage pT4 were predictive of death. The pathologist is a principal actor in the management of RB because his account guide the post-surgical management strategy. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  20. Presenting signs of retinoblastoma at a tertiary level teaching ...

    African Journals Online (AJOL)

    The commonest presenting sign was proptosis 22(53.7%) followed by leucocorea nine (22%),ocular inflammation four (9.0 %), strabismus three (7.3%), glaucoma one (2.4%), loss of vision one (2.4%)and hyphemaone (2.4%). Conclusion: The commonest presenting signs of retinoblastoma in our set up were Proptosis ...

  1. Discharge and infection in retinoblastoma post-enucleation sockets

    NARCIS (Netherlands)

    Mourits, Daphne L.; Hartong, Dyonne T.; Budding, Andries E.; Bosscha, Machteld I.; Tan, H. Stevie; Moll, Annette C.

    2017-01-01

    To investigate the causes and treatment options for socket discharge and infection in patients enucleated for retinoblastoma (Rb). A questionnaire was filled out by (parents of) ocular prosthesis-wearing patients with a history of enucleation as treatment for Rb. We collected data on patients'

  2. Multiple malignancies in a patient with bilateral retinoblastoma

    NARCIS (Netherlands)

    Ceha, H. M.; Balm, A. J.; de Jong, D.; van 't Veer, L. J.

    1998-01-01

    A case is presented of a patient with bilateral retinoblastoma, treated at infancy with surgery, chemotherapy and radiotherapy, who subsequently developed at least four additional histologically distinct malignancies: a Ewing sarcoma of the left fibula, two extraskeletal osteosarcomas of the left

  3. RB1 mutations and second primary malignancies after hereditary retinoblastoma

    NARCIS (Netherlands)

    Dommering, Charlotte J.; Marees, Tamara; van der Hout, Annemarie H.; Imhof, Saskia M.; Meijers-Heijboer, Hanne; Ringens, Peter J.; van Leeuwen, Flora E.; Moll, Annette C.

    2012-01-01

    Survivors of hereditary retinoblastoma have a high risk of second primary malignancies, but it has not been investigated whether specific RB1 germline mutations are associated with greater risk of second primary malignancies in a large cohort. We conducted a retrospective cohort study of 199

  4. Retinoblastoma in Adolescence: Report of an Unusual Presentation

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Khalili

    2010-04-01

    Full Text Available Herein, we report the clinical, pathologic and photographic findings of a 16year-old girl who presented with gradual enlargement of a vascularized, hemorrhagicperipapillary mass that eventually led to vitreous hemorrhage and rubeosis iridis.Histopathological findings after enucleation were positive for retinoblastoma. Thepatient did not have any metastasis during her 20 months of follow up.

  5. RB1 mutations and second primary malignancies after hereditary retinoblastoma

    NARCIS (Netherlands)

    Dommering, Charlotte J.; Marees, Tamara; van der Hout, Annemarie H.; Imhof, Saskia M.; Meijers-Heijboer, Hanne; Ringens, Peter J.; van Leeuwen, Flora E.; Moll, Annette C.

    Survivors of hereditary retinoblastoma have a high risk of second primary malignancies, but it has not been investigated whether specific RB1 germline mutations are associated with greater risk of second primary malignancies in a large cohort. We conducted a retrospective cohort study of 199

  6. Optimized lens-sparing treatment of retinoblastoma with electron beams

    NARCIS (Netherlands)

    Steenbakkers, RJHM; Altschuler, MD; DAngio, GJ; Goldwein, JW; Kassaee, A

    1997-01-01

    Purpose: The ideal lens-sparing radiotherapy technique for retinoblastoma calls for 100% dose to the entire retina including the ora serrata and zero dose to the lens, Published techniques, most of which use photons, have not accomplished this ideal treatment. We describe here a technique that

  7. Presentation of retinoblastoma at a paediatric eye clinic in Ghana ...

    African Journals Online (AJOL)

    Background: Retinobalstoma, the commonest childhood malignant intraocular tumour, is usually diagnosed early with over 90% survival rate in developed countries. In developing countries, the diagnosis is late resulting in less than 50% survival. Objective: To determine retinoblastoma stages at presentation and patients¡¦ ...

  8. Implicaciones teóricas y empíricas de la nueva definición de desempleo en Colombia.

    Directory of Open Access Journals (Sweden)

    Juan Carlos Guataqui

    2010-05-01

    Full Text Available En junio de 2000 Colombia adoptó una nueva definición de desempleo siguiendo los estándares de la OIT. Este cambio implicó una reducción de la tasa de desempleo del orden de dos puntos porcentuales. En este documento contrastamos el caso Colombiano con las experiencias de otros países en términos de la transformación metodológica y sus implicaciones empíricas. Posteriormente, evaluamos el soporte empírico del cambio de metodología. Nuestros resultados sugieren implicaciones específicas sobre el desempleo estructural y su relación con el perfil educativo de los desempleados; por lo tanto, cuestionan la aplicación práctica de la definición estándar de desempleo de la OIT al caso colombiano.

  9. Proton Radiation Therapy for the Treatment of Retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Mouw, Kent W. [Harvard Radiation Oncology Program, Boston, Massachusetts (United States); Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Sethi, Roshan V.; Yeap, Beow Y.; MacDonald, Shannon M.; Chen, Yen-Lin E.; Tarbell, Nancy J.; Yock, Torunn I.; Munzenrider, John E.; Adams, Judith [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Grabowski, Eric [Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts (United States); Mukai, Shizuo [Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts (United States); Shih, Helen A., E-mail: hshih@partners.org [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)

    2014-11-15

    Purpose: To investigate long-term disease and toxicity outcomes for pediatric retinoblastoma patients treated with proton radiation therapy (PRT). Methods and Materials: This is a retrospective analysis of 49 retinoblastoma patients (60 eyes) treated with PRT between 1986 and 2012. Results: The majority (84%) of patients had bilateral disease, and nearly half (45%) had received prior chemotherapy. At a median follow-up of 8 years (range, 1-24 years), no patients died of retinoblastoma or developed metastatic disease. The post-PRT enucleation rate was low (18%), especially in patients with early-stage disease (11% for patients with International Classification for Intraocular Retinoblastoma [ICIR] stage A-B disease vs 23% for patients with ICIR stage C-D disease). Post-PRT ophthalmologic follow-up was available for 61% of the preserved eyes (30 of 49): 14 of 30 eyes (47%) had 20/40 visual acuity or better, 7 of 30 (23%) had moderate visual acuity (20/40-20/600), and 9 of 30 (30%) had little or no useful vision (worse than 20/600). Twelve of 60 treated eyes (20%) experienced a post-PRT event requiring intervention, with cataracts the most common (4 eyes). No patients developed an in-field second malignancy. Conclusions: Long-term follow-up of retinoblastoma patients treated with PRT demonstrates that PRT can achieve high local control rates, even in advanced cases, and many patients retain useful vision in the treated eye. Treatment-related ocular side effects were uncommon, and no radiation-associated malignancies were observed.

  10. Can preoperative MR imaging predict optic nerve invasion of retinoblastoma?

    International Nuclear Information System (INIS)

    Song, Kyoung Doo; Eo, Hong; Kim, Ji Hye; Yoo, So-Young; Jeon, Tae Yeon

    2012-01-01

    Purpose: To evaluate the accuracy of pre-operative MRI for the detection of optic nerve invasion in retinoblastoma. Materials and methods: Institutional review board approval and informed consent were waived for this retrospective study. A total of 41 patients were included. Inclusion criteria were histologically proven retinoblastoma, availability of diagnostic-quality preoperative MR images acquired during the 4 weeks before surgery, unilateral retinoblastoma, and normal-sized optic nerve. Two radiologists retrospectively reviewed the MR images independently. Five imaging findings (diffuse mild optic nerve enhancement, focal strong optic nerve enhancement, optic sheath enhancement, tumor location, and tumor size) were evaluated against optic nerve invasion of retinoblastoma. The predictive performance of all MR imaging findings for optic nerve invasion was also evaluated by the receiver operating characteristic curve analysis. Results: Optic nerve invasion was histopathologically confirmed in 24% of study population (10/41). The differences in diffuse mild enhancement, focal strong enhancement, optic sheath enhancement, and tumor location between patients with optic nerve invasion and patients without optic nerve invasion were not significant. Tumor sizes were 16.1 mm (SD: 2.2 mm) and 14.9 mm (SD: 3.6 mm) in patients with and without optic nerve involvement, respectively (P = 0.444). P-Values from binary logistic regression indicated that all five imaging findings were not significant predictors of tumor invasion of optic nerve. The AUC values of all MR imaging findings for the prediction of optic nerve invasion were 0.689 (95% confidence interval: 0.499–0.879) and 0.653 (95% confidence interval: 0.445–0.861) for observer 1 and observer 2, respectively. Conclusion: Findings of MRI in patients with normal-sized optic nerves have limited usefulness in preoperatively predicting the presence of optic nerve invasion in retinoblastoma.

  11. Can preoperative MR imaging predict optic nerve invasion of retinoblastoma?

    Energy Technology Data Exchange (ETDEWEB)

    Song, Kyoung Doo, E-mail: kdsong0308@gmail.com [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-Dong, Kangnam-Ku, Seoul 135-710 (Korea, Republic of); Eo, Hong, E-mail: rtombow@gmail.com [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-Dong, Kangnam-Ku, Seoul 135-710 (Korea, Republic of); Kim, Ji Hye, E-mail: jhkate.kim@samsung.com [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-Dong, Kangnam-Ku, Seoul 135-710 (Korea, Republic of); Yoo, So-Young, E-mail: sy1131.yoo@samsung.com [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-Dong, Kangnam-Ku, Seoul 135-710 (Korea, Republic of); Jeon, Tae Yeon, E-mail: hathor97.jeon@samsung.com [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-Dong, Kangnam-Ku, Seoul 135-710 (Korea, Republic of)

    2012-12-15

    Purpose: To evaluate the accuracy of pre-operative MRI for the detection of optic nerve invasion in retinoblastoma. Materials and methods: Institutional review board approval and informed consent were waived for this retrospective study. A total of 41 patients were included. Inclusion criteria were histologically proven retinoblastoma, availability of diagnostic-quality preoperative MR images acquired during the 4 weeks before surgery, unilateral retinoblastoma, and normal-sized optic nerve. Two radiologists retrospectively reviewed the MR images independently. Five imaging findings (diffuse mild optic nerve enhancement, focal strong optic nerve enhancement, optic sheath enhancement, tumor location, and tumor size) were evaluated against optic nerve invasion of retinoblastoma. The predictive performance of all MR imaging findings for optic nerve invasion was also evaluated by the receiver operating characteristic curve analysis. Results: Optic nerve invasion was histopathologically confirmed in 24% of study population (10/41). The differences in diffuse mild enhancement, focal strong enhancement, optic sheath enhancement, and tumor location between patients with optic nerve invasion and patients without optic nerve invasion were not significant. Tumor sizes were 16.1 mm (SD: 2.2 mm) and 14.9 mm (SD: 3.6 mm) in patients with and without optic nerve involvement, respectively (P = 0.444). P-Values from binary logistic regression indicated that all five imaging findings were not significant predictors of tumor invasion of optic nerve. The AUC values of all MR imaging findings for the prediction of optic nerve invasion were 0.689 (95% confidence interval: 0.499–0.879) and 0.653 (95% confidence interval: 0.445–0.861) for observer 1 and observer 2, respectively. Conclusion: Findings of MRI in patients with normal-sized optic nerves have limited usefulness in preoperatively predicting the presence of optic nerve invasion in retinoblastoma.

  12. Retinoblastoma atípico: a propósito de un caso Atypic retinoblastoma: apropos of a case

    Directory of Open Access Journals (Sweden)

    Beatriz N. Rodríguez Rodríguez

    2003-06-01

    Full Text Available En una niña de 11 años de edad se presentó un caso atípico de retinoblastoma unilateral y se consultó inicialmente por una hemorragia vítrea. El ultrasonido no orientó diagnóstico. Posteriormente apareció un hifema total espontáneo con hipertensión ocular incontrolable que decidió la enucleación. El estudio anátomo-patológico concluyó un retinoblastoma poco diferenciado con extensa área de necrosis y hemorragia intratumoral.An atypic case of unilateral retinoblastoma was reported in an 11-year-old girl that was seen due to a vitreal hemorrhage at first. The ultrasound did not help to make a diagnosis. Later on, a total spontaneous hyphema with uncontrollable ocular hypertension appeared that led surgeons to perform enucleation. By the anatomopathological study, it was concluded that it was a little differentiated retinoblastoma with an extensive area of necrosis and intratumoral hemorrhage.

  13. El desarrollo turístico en la isla de Lanzarote: las implicaciones económicas y ecológicas

    Directory of Open Access Journals (Sweden)

    Alejandro González Morales

    2013-11-01

    Full Text Available El presente trabajo versa sobre las implicaciones medioambientales del desarrollo turístico en la isla de Lanzarote. En este sentido hemos comprobado como su crecimiento afecta al resto de las actividades y ha terciarizado de forma considerable la economía insular.The present article is on turist's develop of Lanzarote Island (Lanary Island. The agriculture is going down, whole than the tourist is over. The economy of island is very third.

  14. Neoadjuvant/adjuvant treatment of high-risk retinoblastoma: a report from the German Retinoblastoma Referral Centre.

    Science.gov (United States)

    Künkele, Annette; Wilm, Josephine; Holdt, Markus; Lohmann, Dietmar; Bornfeld, Norbert; Eggert, Angelika; Temming, Petra; Schulte, Johannes H

    2015-07-01

    Retinoblastoma can extend beyond the structures of the eye, where cells can enter the bloodstream and cause metastases. Various types of protocols for adjuvant treatment risk-adapted according to histopathological risk factors are used worldwide. Between 1997 and 2009, 420 children were diagnosed with retinoblastoma at the German Retinoblastoma Referral Centre and risk factors were assessed. Patients with post-laminar optic nerve infiltration or choroid or minor scleral invasion received six courses of adjuvant chemotherapy using vincristine, etoposide, carboplatin and cyclophosphamide (group 1). Patients with microscopic extension beyond the sclera to the resection margin of the optic nerve or potential spread due to vitrectomy received chemotherapy plus orbital radiotherapy (group 2). Neoadjuvant chemotherapy was performed in patients with local extraocular invasion detected on MRI. Following this protocol, 42 of the 420 patients and 21 referred from other centres showed high-risk histopathological factors qualifying for adjuvant therapy (57 in group 1 and 6 in group 2). Seven of the 63 patients received neoadjuvant and adjuvant treatment. During a mean follow-up of 5.8 (range 0.4-15.4) years, one of six patients in group 2 developed metastases and died. No patients died from toxicity. The 5-year overall survival was 100% for group 1 and 80% for group 2. This retrospective single-site study reveals a 10% incidence of high-risk features in children with retinoblastoma diagnosed at the German Retinoblastoma Referral Centre. Overall survival rates of 98.3% underline the safety of this adjuvant chemotherapy protocol and its efficiency in preventing metastasis. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  15. Implicaciones jurídicas de los alimentos transgénicos en Colombia

    Directory of Open Access Journals (Sweden)

    Mario Ernesto García Martínez

    2003-01-01

    Full Text Available Las implicaciones juridicas de los alimentos transgénicos en Colombia demuestra que es necesario que se establezca un marco legal de Bioseguridad sólido. Es imperativo que la autoridad medioambiental, entendiendo por éstá no sólo el Ministerio del Medio Ambiente sino también, el Ministerio de Salud, el Ministerio de Agricultura, el lCA y ellNVlMA, desarrollen una política integral de Bioseguridad y Biotecnología, y como consecuencia de ello presenten cuanto antes un proyecto de Ley Marco que se encargue de regular la Biotecnología en Colombia

  16. La comprensión de las organizaciones empresariales y su ambiente como sistemas de complejidad creciente: rasgos e implicaciones

    Directory of Open Access Journals (Sweden)

    Luz Esperanza Bohórquez

    2016-10-01

    Método: en el documento se revisan las características de los sistemas de complejidad creciente y se identifican los elementos que explican su capacidad de auto-organización. A partir de esta revisión se plantean las implicaciones de comprender a las organizaciones como sistemas de complejidad creciente, las cuales se articulan con recientes investigaciones que en ingeniería organizacional y gestión buscan incrementar la capacidad de adaptación del sistema. Resultados: se desarrolla una apreciación sobre las implicaciones en la ingeniería organizacional de diseñar organizaciones empresariales con mayor capacidad para auto-organizarse y de manera amplia de aprovechar la complejidad creciente del entorno. Conclusiones: la comprensión de las organizaciones empresariales como sistemas de complejidad creciente ofrece una perspectiva notoriamente distinta al paradigma tradicional el cual se han caracterizado por el enfoque reduccionista. A la fecha la investigación al respecto se encuentra en etapas tempranas y no existen modelos o evidencias empíricas que permitan corroborar de manera amplia y completa la fuerza de tales ideas. Sin embargo, los altos niveles de agilidad, flexibilidad y robustez que exhiben los sistemas auto-organizados permiten proyectar importantes campos de investigación alrededor del diseño de estructuras organizacionales flexibles, formas de gobernanza, toma decisiones en ausencia de controlador central, etc.

  17. Implicaciones ambientales de las tecnologías de energía renovable

    Directory of Open Access Journals (Sweden)

    Jan Mahirt-Smith

    2011-12-01

    Full Text Available Las tecnologías de energía renovable como la eólica, la solar y la biomasa, hacen un uso del suelo más intenso que las de combustibles fósiles tradicionales y, geográficamente, sus implicaciones ambientales son más heterogéneas, por lo que presentan un gran desafío para las técnicas de evaluación de su ciclo de vida. Este trabajo presenta los resultados de una investigación bibliográfica alrededor de los siguientes temas: 1 cambios en el uso del suelo debido a la mayor producción de energía renovable; 2 impactos del uso de suelo; 3 variabilidad geográfica en el inventario de datos; y 4 efectos de la distribución de energía. Además, se revisa el grado de investigación que actualmente se aplica acerca de las tecnologías de energía renovable en campos como el eólico, el solar y la bioenergía y en la evaluación del ciclo de vida en general.

  18. Naturally death-resistant precursor cells revealed as the origin of retinoblastoma

    DEFF Research Database (Denmark)

    Trinh, Emmanuelle; Lazzerini Denchi, Eros; Helin, Kristian

    2004-01-01

    The molecular mechanisms and the cell-of-origin leading to retinoblastoma are not well defined. In this issue of Cancer Cell, Bremner and colleagues describe the first inheritable model of retinoblastoma, revealing that loss of the pocket proteins pRb and p107 deregulates cell cycle exit in retinal...... precursors. The authors show that a subset of these precursors contain an inherent resistance to apoptosis, and that while most terminally differentiate, some are likely to acquire additional mutations, leading to tumor formation. Thus, this work defines the cell-of-origin of retinoblastoma and suggests...... that mutations giving increased proliferative capacity are required for retinoblastoma development....

  19. MicroRNAs-449a and -449b exhibit tumor suppressive effects in retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Alissa [Division of Hematology, Oncology, and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611 (United States); Jones, Aunica [Cancer Biology and Epigenomics Program, Ann and Robert H. Lurie Children’s Hospital of Chicago Research Center, Chicago, IL 60611 (United States); Bryar, Paul J. [Departments of Ophthalmology and Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 (United States); Mets, Marilyn [Division of Ophthalmology, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611 (United States); Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 (United States); Weinstein, Joanna [Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 (United States); Division of Hematology, Oncology, and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611 (United States); Zhang, Gang [Biostatistics Research Core, Ann and Robert H. Lurie Children’s Hospital of Chicago Research Center, Chicago, IL 60611 (United States); Laurie, Nikia A., E-mail: n-laurie@northwestern.edu [Cancer Biology and Epigenomics Program, Ann and Robert H. Lurie Children’s Hospital of Chicago Research Center, Chicago, IL 60611 (United States); Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 (United States)

    2013-11-01

    Highlights: •We validate miR-449a/b expression in primary human retinoblastomas and cell lines. •Exogenous miRs-449a/b inhibited proliferation in retinoblastoma cell lines. •Exogenous miRs-449a/b increased apoptosis in retinoblastoma cell lines. •miRs-449a/b could serve as viable therapeutic targets for retinoblastoma treatment. -- Abstract: Retinoblastoma is the most common pediatric cancer of the eye. Currently, the chemotherapeutic treatments for retinoblastoma are broad-based drugs such as vincristine, carboplatin, or etoposide. However, therapies targeted directly to aberrant signaling pathways may provide more effective therapy for this disease. The purpose of our study is to illustrate the relationship between the expressions of miRs-449a and -449b to retinoblastoma proliferation and apoptosis. We are the first to confirm an inhibitory effect of miR-449a and -449b in retinoblastoma by demonstrating significantly impaired proliferation and increased apoptosis of tumor cells when these miRNAs are overexpressed. This study suggests that these miRNAs could serve as viable therapeutic targets for retinoblastoma treatment.

  20. Evaluación multicriterio del proyecto minero "Cobre las Cruces", Gerena (Sevilla) : análisis de riesgos para los recursos hídricos

    OpenAIRE

    Beltrán Muñoz, María Jesús

    2008-01-01

    El objetivo de este trabajo es el análisis de las posibles implicaciones sobre los recursos hídricos de una explotación minera. Concretamente, se analizarán estas implicaciones en el estudio de caso del proyecto minero Cobre Las Cruces, propiedad de la empresa canadiense Inmet Mining Corporation.

  1. Radiation management of bilateral retinoblastoma: the need to preserve vision

    International Nuclear Information System (INIS)

    Gagnon, J.D.; Ware, C.M.; Moss, W.T.; Stevens, K.R.

    1980-01-01

    Thirty-four patients with retinoblastoma were treated in the Radiation Therapy Department of the University of Oregon Health Sciences Center from 1944 to 1978. Twenty-five of these patients had bilateral disease. Most patients were treated with megavoltage equipment and received doses of 5000 rad in 5 weeks. According to the lifetable method, five year survival was 67.6%; it increased to 85.7% if patients who were treated with orthovoltage equipment were excluded. Seventy-one percent of evaluable patients had useful vision at 5 years; an additional two patients had useful vision for two years after radiation therapy. The value of even limited vision during this critical time of sensorimotor and psychological development is discussed. Orthovoltage equipment should not be used to irradiate patients with retinoblastoma

  2. Aspiration of radiation cataract in children of retinoblastoma

    International Nuclear Information System (INIS)

    Kawashima, Hidetoshi; Minoda, Kensei.

    1985-01-01

    We operated on the radiation cataracts of 12 retinoblastoma patients who had been treated by conservative therapeutic means including radiation, cryoapplication, photocoagulation, and cytostatic agents. Before the surgery, we checked that the tumor had disappeared or scarred by means of CT-scan, Ultrasonography, X-ray, and so on. Visual acuity of 1.0 or more was retained in two eyes (17 %). Four eyes (33 %) retained visual acuity of 0.6-0.4, one eye (8 %) retained 0.1 and the remaining five eyes (42 %) had visual acuity of less than 0.1. We experienced no serious complications during or after the surgeries. The reason for poorer visual acuity was either macular involvement of the tumor or radiation retinopathy due to larger dosis of radiation. Therefore, we conclude that aspiration of radiation cataract is an effective treatment of retinoblastoma patients after the tumor has disappeared or scarred. (author)

  3. Causes, outcome and prevention of abandonment in retinoblastoma in India.

    Science.gov (United States)

    Kumar, Archana; Moulik, Nirmalya Roy; Mishra, Ravi Krishna; Kumar, Dipak

    2013-05-01

    The high-cure rates of 90% in retinoblastoma are not replicated in developing countries due to late presentation and poor compliance to treatment. The present study takes a closer look at causes of abandonment of therapy and effectiveness of counselling in reducing abandonment. A retrospective study of children with retinoblastoma registered at our centre from March 2008 through August 2011. Fifty (49.50%) of 101 children registered for treatment abandoned therapy. Abandonment rates were significantly higher in rural as compared to urban children (P = 0.02). There was no significant difference in rate of abandonment between stages or laterality of disease and other socio-demographic factors. Telephone calls were more effective than letters in tracing patients (31.2% vs. 2.4%). Major reasons cited behind abandonment were financial problems (30%) and unwillingness to enucleate (20%). Of the 12 children who returned and were retreated 6 (50%) died of progressive disease. Nineteen (73%) of those who did not return died at home. Abandonment rates steadily declined from 71.42% in 2008 to 16.66% in 2011 (P = 0.01) due to effective pre-abandonment counselling by a support team under the National Retinoblastoma Registry of India from 2009. Abandonment rates for children with retinoblastoma continue to be unacceptably high. Rural background, financial constraints and hesitancy to enucleate were important causes behind abandonment. Outcome of patients who abandoned treatment was uniformly dismal. Inclusion of support team and intensified initial counselling helped in improving compliance. Copyright © 2013 Wiley Periodicals, Inc.

  4. {sup 106}Ruthenium Plaque Therapy (RPT) for Retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Murakami, Naoya, E-mail: namuraka@ncc.go.jp [Department of Radiation Oncology, National Cancer Center Hospital, Tokyo (Japan); Suzuki, Shigenobu [Department of Ophthalmic Oncology, National Cancer Center Hospital, Tokyo (Japan); Ito, Yoshinori [Department of Radiation Oncology, National Cancer Center Hospital, Tokyo (Japan); Yoshimura, Ryoichi [Department of Diagnostic Radiology and Oncology, Head and Neck Reconstruction Division, Graduate School, Tokyo Medical and Dental University, Tokyo (Japan); Inaba, Koji; Kuroda, Yuki; Morota, Madoka; Mayahara, Hiroshi; Sakudo, Mototake; Wakita, Akihisa; Okamoto, Hiroyuki; Sumi, Minako; Kagami, Yoshikazu [Department of Radiation Oncology, National Cancer Center Hospital, Tokyo (Japan); Nakagawa, Keiichi; Ohtomo, Kuni [Department of Radiology, University of Tokyo Hospital, Tokyo (Japan); Itami, Jun [Department of Radiation Oncology, National Cancer Center Hospital, Tokyo (Japan)

    2012-09-01

    Purpose: To evaluate the effectiveness of episcleral {sup 106}ruthenium plaque therapy (RPT) in the management of retinoblastoma. Methods and Materials: One hundred one RPTs were retrospectively analyzed that were performed in 90 eyes of 85 patients with retinoblastoma at National Cancer Center Hospital between 1998 and 2008. Each RPT had a corresponding tumor and 101 tumors were considered in the analysis of local control. Median follow-up length was 72.8 months. Median patient age at the RPT was 28 months. Median prescribed doses at reference depth and outer surface of the sclera were 47.4 Gy and 162.3 Gy, respectively. Results: Local control rate (LCR) and ocular retention rate (ORR) at 2 years were 33.7% and 58.7%, respectively. Unilateral disease, International Classification of Retinoblastoma group C or more advanced at the first presentation or at the time of RPT, vitreous and/or subretinal seeding, tumor size greater than 5 disc diameter (DD), reference depth greater than 5 mm, dose rate at reference depth lower than 0.7 Gy/hour, dose at the reference depth lower than 35 Gy, and (biologically effective dose with an {alpha}/{beta} ratio of 10 Gy) at the reference depth lower than 40 Gy{sub 10} were associated with unfavorable LCR. Two patients died of metastatic disease. Radiation complications included retinal detachment in 12 eyes (13.3%), proliferative retinopathy in 6 (6.7%), rubeosis iris in 2 (2.2%), and posterior subcapsular cataract in 23 (25.6%). Conclusion: RPT is an effective eye-preserving treatment for retinoblastoma.

  5. Thermography in the diagnosis of retinoblastoma in children

    International Nuclear Information System (INIS)

    Bogdasarov, Yu.B.; Lenskaya, O.P.; Belkina, B.M.

    1985-01-01

    The authors presented the results of thermographic examination in combination with echography and computerized tomography were presented in children with suspected retinoblastoma (30 primary examined patients and 30 patients examined to assess therapeutic efficacy). The results of the examination showed the relationship of the hyperthermia zone with tumor stage. All the patients recieved remote gamma-therapy and polychemotherapy. The usefulness of the thermographic method for efficacy assessment was shown

  6. Postradiation leiomyosarcoma of the orbit complicating bilateral retinoblastoma

    International Nuclear Information System (INIS)

    Font, R.L.; Jurco, S.; Brechner, R.J.

    1983-01-01

    A 31-year-old woman had bilateral retinoblastoma diagnosed in early childhood. The right eye was enucleated at the age of 1 year, and the left eye was treated with radiation therapy (a total dose of 16,000 rad). Twenty-three years later, in 1975, a subcutaneous mass was noted in the left periorbital region. A biopsy specimen of the mass was taken and a diagnosis of pleomorphic postradiation sarcoma was made. Electron microscopic studies of the periorbital mass confirmed the diagnosis of leiomyosarcoma. After additional radiation therapy, the residual mass was surgically excised. Five years later, a right renal mass, which histologically proved to be a renal cell carcinoma, was discovered. She was treated with nephrectomy, radiation, and chemotherapy. A recent follow-up examination disclosed that the patient is alive and apparently without any evidence of metastatic disease, 30 years after the diagnosis of bilateral retinoblastoma was made. The literature is reviewed regarding postradiation sarcomas and the occurrence of second malignant neoplasms in patients with retinoblastoma

  7. Postradiation leiomyosarcoma of the orbit complicating bilateral retinoblastoma.

    Science.gov (United States)

    Font, R L; Jurco, S; Brechner, R J

    1983-10-01

    A 31-year-old woman had bilateral retinoblastoma diagnosed in early childhood. The right eye was enucleated at the age of 1 year, and the left eye was treated with radiation therapy (a total dose of 16,000 rad). Twenty-three years later, in 1975, a subcutaneous mass was noted in the left periorbital region. A biopsy specimen of the mass was taken and a diagnosis of pleomorphic postradiation sarcoma was made. Electron microscopic studies of the periorbital mass confirmed the diagnosis of leiomyosarcoma. After additional radiation therapy, the residual mass was surgically excised. Five years later, a right renal mass, which histologically proved to be a renal cell carcinoma, was discovered. She was treated with nephrectomy, radiation, and chemotherapy. A recent follow-up examination disclosed that the patient is alive and apparently without any evidence of metastatic disease, 30 years after the diagnosis of bilateral retinoblastoma was made. The literature is reviewed regarding postradiation sarcomas and the occurrence of second malignant neoplasms in patients with retinoblastoma.

  8. CT and MR findings in retinoblastoma : correlation with histopathologic examination

    International Nuclear Information System (INIS)

    Park, Son Won; Han, Moon Hee; Chi, Je G.; Yu, Young Suk; Kim, Yeon Mee; Chung, Jin Haeng; Yu, In Kyu; Chang, Kee Hyun; Yeon, Kyung Mo

    1997-01-01

    To evaluate histopathologic correlation of the component of the lesion on CT and MR of retinoblastomas. Gross pathologic findings of 24 enucleated eyeballs in 24 patients with retinoblastomas were compared with preoperative CT (n=19) and MR (n=5) findings. In eight eyeballs, in which there were findings other than mass, histopathologic findings were reviewed and correlated with image findings. Retinal detachment and subretinal hemorrhage which were not detected on CT were demonstrated in two of eight eyeballs on histopathologic examination. In one eyeball, retinal detachment and subretinal effusion were detected on both CT and in a pathologic specimen. In two eyeballs with peripheral heterogeneous MR enhancement of the masses, tumor necrosis and calcification were demonstrated in the central non-emhancing portion of the mass, In two eveballs, linear soft tissue along the retina apart from the main mass were revealed as tumor spread along the retinal surface. In one patient, retinal thickening on MR was presumed to be an MR artifact and no lesion was found in the gross specimen. On CT, retinal detachment and subretinal hemorrhage associated with retinoblastoma can mimic mass, and tumor spread along the retinal surface can be seen as a linear retinal lesion. On MR, tumor necrosis and calcification can be a cause of heterogeneous enhancement

  9. Decreased expression of MEG3 contributes to retinoblastoma progression and affects retinoblastoma cell growth by regulating the activity of Wnt/β-catenin pathway.

    Science.gov (United States)

    Gao, Yali; Lu, Xiaohe

    2016-02-01

    The aberrant expression of MEG3 has been found in some types of cancers; however, little is known concerning the function of MEG3 in retinoblastoma. To elucidate the roles of MEG3 in retinoblastoma, MEG3 expression was quantified in 63 retinoblastoma samples and corresponding nontumor tissues in this work. Moreover, retinoblastoma cell lines were transfected with pcDNA3.1-MEG3 or si-MEG3, after which proliferation, apoptosis, and expression of β-catenin were assayed. TOP-Flash reporter assay was also used to investigate the activity of the Wnt/β-catenin pathway. The results showed that MEG3 was downregulated in retinoblastoma tissues, and the level of MEG3 was negatively associated with IIRC stages and nodal or distant metastasis. More importantly, Kaplan-Meier survival analysis demonstrated that patients with low MEG3 expression had poorer survival and multivariate Cox regression analysis revealed that MEG3 was an independent prognostic factor in retinoblastoma patients. We also observed that MEG3 expression can be modulated by DNA methylation by using 5-aza-CdR treatment. In addition, overexpression of MEG3 suppressed proliferation, promoted apoptosis, and influences the activity of the Wnt/β-catenin pathway in retinoblastoma cell lines. Furthermore, we found that Wnt/β-catenin pathway activator rescued the anticancer effect of MEG3 in retinoblastoma. In conclusion, our study for the first time demonstrated that MEG3 was a tumor suppressor by negatively regulating the activity of the Wnt/β-catenin pathway in the progression of retinoblastoma and might serve as a prognostic biomarker and molecular therapeutic target.

  10. La Representabilidad del Genocidio

    OpenAIRE

    Cardona González, Lorena

    2012-01-01

    El presente artículo intenta hacer una aproximación histórica y analítica al fenómeno del Genocidio, sus implicaciones sociales y culturales que dieron como resultado la reformulación analítica y conceptual de hechos que hasta entonces superaban el conocimiento y la moral humana. De este modo, se hace un trayecto histórico de la paulatina aparición del asesinato masivo como practica de Estado, enmarcado en las experiencias del genocidio armenio y el alemán. A su vez, se hace una mirada sobre ...

  11. World disparities in risk definition and management of retinoblastoma: a report from the International Retinoblastoma Staging Working Group.

    Science.gov (United States)

    Chantada, Guillermo L; Doz, François; Orjuela, Manuela; Qaddoumi, Ibrahim; Sitorus, Rita S; Kepak, Tomas; Furmanchuk, Anna; Castellanos, Mauricio; Sharma, Tarun; Chevez-Barrios, Patricia; Rodriguez-Galindo, Carlos

    2008-03-01

    Following from the publication of the International Retinoblastoma Staging System, an open internet discussion group was created at the www.cure4kids.org resource. The results of a survey distributed among participants are discussed. Although most patients with retinoblastoma were treated under prospective protocols, there was a wide variation in the definition of risk criteria and in the criteria for giving adjuvant chemotherapy following enucleation. Definition of high-risk histological features and the criteria for use of adjuvant therapy will be standardized in future studies. Internet meetings are a valuable mechanism for enabling participation from under-resourced countries in the development of cooperative studies. (c) 2007 Wiley-Liss, Inc.

  12. TRAUMA OCULAR CERRADO: MANIFESTACIONES, MANEJO E IMPLICACIONES EN EL BOXEO Y EL FÚTBOL

    Directory of Open Access Journals (Sweden)

    Álvaro Rodríguez González

    2014-12-01

    Full Text Available El trauma ocular cerrado según su grado puede ser ligero moderado o severo. En algunos casos permanece inadvertido o enmascarado y crea consecuencias por lo que debe ser investigado. El trauma tiene características y deja huellas, algunas evidentes y otras ocultas que pueden aparecer en la historia clínica o deben ser buscadas en el segmento anterior ocular en donde se pueden observar trastornos del reflejo pupilar, (incluye midriasis paralítica, laceraciones palpebrales, hemorragia orbitaria, hifema (hemorragia en cámara anterior y fracturas óseas, orbitaria o maxilofacial. En biomicroscopía, pueden observarse laceraciones corneanas, a veces sutiles, otras veces son cicatrices perforantes enmascaradas, acompañadas interiormente de sinequia anterior del iris a la cicatriz de la córnea. También, heridas corneanas recientes, diálisis del iris, a veces extensas en su base, con retroinserción angular de variable extensión y tunelización supracoroidea que inducen, bien a hipotonía ocular o a elevación de la tensión ocular y establecimiento de glaucomas. El trauma ocular cerrado es importante por haberse convertido en un problema de salud pública dadas sus implicaciones en niños, en trabajadores y en aficionados y profesionales en los deportes.

  13. sus implicaciones didácticas

    Directory of Open Access Journals (Sweden)

    Cristina Furió-Gómez

    2007-01-01

    Full Text Available En este trabajo se realiza una breve introducción histórica y epistemológica del nacimiento de la termodinámica como ciencia moderna. Se muestra, así mismo, como esta historia puede contribuir a mejorar la enseñanza de la termodinámica y a superar algunas dificultades de los estudiantes.

  14. Temperaturas extremas en verano. Implicaciones en salud

    Directory of Open Access Journals (Sweden)

    Julio Díaz Jiménez

    2005-12-01

    Full Text Available El incremento que se ha detectado en las temperaturas estivales en los últimos años, unido las tendencias que se esperan para el clima durante el próximo siglo, hacen prever un aumento en la frecuencia e intensidad de los eventos térmicos extremos, fundamentalmente olas de calor. La clara relación existente entre la temperatura y la mortalidad, hace necesaria una cuantificación para la caracterización de los efectos esperados de la temperatura sobre la mortalidad en las denominadas olas de calor.En este trabajo se presenta una descripción del estado del conocimiento de este problema, haciendo especial referencia a la ola de calor que asoló Europa en el verano de 2003, de cómo se han caracterizado las olas de calor y en base a ello de cuáles son las características que han de tener los planes de alerta y prevención encaminados a minimizar los efectos del calor sobre la salud de la población.

  15. Optical Coherence Tomography-Guided Decisions in Retinoblastoma Management.

    Science.gov (United States)

    Soliman, Sameh E; VandenHoven, Cynthia; MacKeen, Leslie D; Héon, Elise; Gallie, Brenda L

    2017-06-01

    Assess the role of handheld optical coherence tomography (OCT) in guiding management decisions during diagnosis, treatment, and follow-up of eyes affected by retinoblastoma. Retrospective, noncomparative, single-institution case series. All children newly diagnosed with retinoblastoma from January 2011 to December 2015 who had an OCT session during their active treatment at The Hospital for Sick Children (SickKids) in Toronto, Canada. The OCT sessions for fellow eyes of unilateral retinoblastoma without any suspicious lesion and those performed more than 6 months after the last treatment were excluded. Data collected included age at presentation, sex, family history, RB1 mutation status, 8th edition TNMH cancer staging and International Intraocular Retinoblastoma Classification (IIRC), and number of OCT sessions per eye. Details of each session were scored for indication-related details (informative or not) and assessed for guidance (directive or not), diagnosis (staging changed, new tumors found or excluded), treatment (modified, stopped, or modality shifted), or follow-up modified. Frequency of OCT-guided management decisions, stratified by indication and type of guidance (confirmatory vs. influential). Sixty-three eyes of 44 children had 339 OCT sessions over the course of clinical management (median number of OCT scans per eye, 5; range, 1-15). The age at presentation and presence of a heritable RB1 mutation significantly correlated with an increased number of OCT sessions. Indications included evaluation of post-treatment scar (55%) or fovea (16%), and posterior pole scanning for new tumors (11%). Of all sessions, 92% (312/339) were informative; 19 of 27 noninformative sessions had large, elevated lesions; of these, 14 of 19 were T2a or T2b (IIRC group C or D) eyes. In 94% (293/312) of the informative sessions, OCT directed treatment decisions (58%), diagnosis (16%), and follow-up (26%). Optical coherence tomography influenced and changed management from pre

  16. The N Terminus of the Retinoblastoma Protein Inhibits DNA Replication via a Bipartite Mechanism Disrupted in Partially Penetrant Retinoblastomas

    Science.gov (United States)

    Borysov, Sergiy I.; Nepon-Sixt, Brook S.

    2015-01-01

    The N-terminal domain of the retinoblastoma (Rb) tumor suppressor protein (RbN) harbors in-frame exon deletions in partially penetrant hereditary retinoblastomas and is known to impair cell growth and tumorigenesis. However, how such RbN deletions contribute to Rb tumor- and growth-suppressive functions is unknown. Here we establish that RbN directly inhibits DNA replication initiation and elongation using a bipartite mechanism involving N-terminal exons lost in cancer. Specifically, Rb exon 7 is necessary and sufficient to target and inhibit the replicative CMG helicase, resulting in the accumulation of inactive CMGs on chromatin. An independent N-terminal loop domain, which forms a projection, specifically blocks DNA polymerase α (Pol-α) and Ctf4 recruitment without affecting DNA polymerases ε and δ or the CMG helicase. Individual disruption of exon 7 or the projection in RbN or Rb, as occurs in inherited cancers, partially impairs the ability of Rb/RbN to inhibit DNA replication and block G1-to-S cell cycle transit. However, their combined loss abolishes these functions of Rb. Thus, Rb growth-suppressive functions include its ability to block replicative complexes via bipartite, independent, and additive N-terminal domains. The partial loss of replication, CMG, or Pol-α control provides a potential molecular explanation for how N-terminal Rb loss-of-function deletions contribute to the etiology of partially penetrant retinoblastomas. PMID:26711265

  17. Contexto e implicaciones en la vivencia de mujeres autoras de un delito violento ejercido hacia su pareja. Un estudio desde la perspectiva de género

    OpenAIRE

    Alvarado Sánchez, Patricia

    2012-01-01

    En este proyecto se analiza el contexto e implicaciones de mujeres cualificadas como sujeto activo de un delito violento contra su pareja. La problematización del fenómeno investigado se enmarca en un contexto jurídico-social. Comprende los objetivos sobre a) Visualizar la dinámica relacional entre la mujer (género femenino) y su compañero varón (género masculino) previa al delito, b) Comprender los significados atribuidos al episodio y a las circunstancias del delito hacia su pareja, c) Ente...

  18. El cigarrillo: implicaciones para la salud

    Directory of Open Access Journals (Sweden)

    Manuel Antonio Ballén

    2006-07-01

    Full Text Available Antecedentes. El consumo de cigarrillo, según cálculos de la Organización Mundial de la Salud (OMS, es la causa de por lo menos cuatro millones de muertes al año. Las consecuencias de fumar cigarrillo van desde cambios fisiopatológicos en los sistemas respiratorio, cardiovascular y digestivo, hasta trastornos mentales asociados a la dependencia a la nicotina. Objetivo. Realizar una revisión narrativa de la literatura médica mostrando los efectos del consumo de cigarrillo sobre la salud física y mental en los fumadores activos y pasivos. Material y métodos. El artículo se basa en la revisión de artículos a través de la base de datos del MEDLINE y de la biblioteca Virtual de la OMS. Se emplearon en la búsqueda las palabras clave "Cigarette Smoke", "Cancer AND smoke", "COPD AND smoke", "Nicotine Dependence". Se escogieron artículos y libros publicados en idioma inglés entre los años 1994 y 2006, realizando una lectura crítica (análisis de posibles conflictos de interés y errores de diseño. Conclusión. El humo del cigarrillo contiene partículas potencialmente peligrosas para la salud de quien está expuesto a ellas. De este modo, fumar cigarrillo se convierte en un factor etiológico común a muchos tipos de cáncer. Además los componentes del cigarrillo están relacionados con el desarrollo de otros estados patológicos (enfermedad cardiovascular y enfermedad pulmonar obstructiva crónica. La nicotina, uno de sus componentes, es un potente agente adictivo. Todo esto en su conjunto hace del cigarrillo un importante problema de salud pública.

  19. El ciclo de Isidro Parodi: Reinterpretación paródica del relato clásico

    Directory of Open Access Journals (Sweden)

    Héctor Fernando Vizcarra

    2013-02-01

    G.K. Chesterton. El presente texto demuestra cómo la recepción productiva del hipertexto latinoamericano modifica las implicaciones de un motivo literario propio de la ficción de detectives: la carta robada.

  20. Web 3.0: implicaciones educativas

    OpenAIRE

    Grupo TACE. Tecnologías Aplicadas a las Ciencias de la Educación

    2012-01-01

    La Web 3.0 se considera la etapa que sigue a la Web 2.0 o Web social. Todavía no es un término unívoco y suele aparecer unido con la web semántica. Es una extensión del World Wide Web, que permite expresar el lenguaje natural y también utilizar un lenguaje que se puede entender, interpretar y utilizar por agentes software, permitiendo encontrar, compartir e integrar la información más fácilmente. Se trata de un nuevo ciclo en el que la inteligencia artificial se combina con la capacidad de l...

  1. Aspectos biológicos e fisiológicos do envelhecimento humano e suas implicações na saúde do idoso Biological and physiological aspects of aging and its implications in the health of the elderly Aspectos biologicos y fisiologicos del envejecimiento humano u sus implicaciones en la saude del idoso

    Directory of Open Access Journals (Sweden)

    2006-11-01

    Full Text Available Trata o presente texto de uma discussão acerca dos principais aspectos biológicos e fisiológicos do corpo humano, vivenciados a partir da idade adulta e principalmente na terceira idade, os quais apresentam-se com maior fragilidade no que se refere aos padrões normais obtidos durante as fases infantil e adultas do indivíduo. O tema desperta a ênfase para as práticas regulares das atividades físicas (exercícios, esportes, danças, lutas, etc. como uma das formas saudáveis para contrapor e atenuar as causas e os efeitos do envelhecimento corporal, que acomete todas as pessoas na terceira idade. PALAVRAS-CHAVE: Envelhecimento Biológico – Capacidades Funcionais – Exercícios – Terceira Idade. This text deals with a discussion on the main biological and physiological aspects of the human body that are experienced in adulthood, especially among the elderly, who are more fragile regarding the regular standards obtained during childhood and earlier adulthood. This text emphasizes regular physical activity (exercise, sports, dance, martial arts, etc as one of the healthy ways to oppose and ease the causes and effects of bodily aging that affect the elderly. KEY WORDS: Biological aging - Ffunctional capacities -Eexercise - Elderly,Tthird age Trata el presente texto de una discusión acerca de los principales aspectos biológicos y fisiológicos del cuerpo humano, vivenciados a partir de la edad adulta y principalmente en la tercera edad, los cuales se presentan con mayor fragilidad en lo que se refiere a los modelos normales obtenidos durante las fases infantil y adultas del individuo. El tema despierta el énfasis para las prácticas regulares de las actividades físicas (ejercicios, deportes, danzas, luchas, etc. como una de las formas saludables para contraponer y atenuar las causas y los efectos del envejecimiento corporal, que acomete todas las personas en la tercera edad. PALABRAS CLAVES: Envejecimiento Biológico

  2. BTG interacts with retinoblastoma to control cell fate in Dictyostelium.

    Directory of Open Access Journals (Sweden)

    Daniele Conte

    Full Text Available BACKGROUND: In the genesis of many tissues, a phase of cell proliferation is followed by cell cycle exit and terminal differentiation. The latter two processes overlap: genes involved in the cessation of growth may also be important in triggering differentiation. Though conceptually distinct, they are often causally related and functional interactions between the cell cycle machinery and cell fate control networks are fundamental to coordinate growth and differentiation. A switch from proliferation to differentiation may also be important in the life cycle of single-celled organisms, and genes which arose as regulators of microbial differentiation may be conserved in higher organisms. Studies in microorganisms may thus contribute to understanding the molecular links between cell cycle machinery and the determination of cell fate choice networks. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that in the amoebozoan D. discoideum, an ortholog of the metazoan antiproliferative gene btg controls cell fate, and that this function is dependent on the presence of a second tumor suppressor ortholog, the retinoblastoma-like gene product. Specifically, we find that btg-overexpressing cells preferentially adopt a stalk cell (and, more particularly, an Anterior-Like Cell fate. No btg-dependent preference for ALC fate is observed in cells in which the retinoblastoma-like gene has been genetically inactivated. Dictyostelium btg is the only example of non-metazoan member of the BTG family characterized so far, suggesting that a genetic interaction between btg and Rb predated the divergence between dictyostelids and metazoa. CONCLUSIONS/SIGNIFICANCE: While the requirement for retinoblastoma function for BTG antiproliferative activity in metazoans is known, an interaction of these genes in the control of cell fate has not been previously documented. Involvement of a single pathway in the control of mutually exclusive processes may have relevant implication in the

  3. Intravitreal chemotherapy in retinoblastoma: expanded use beyond intravitreal seeds.

    Science.gov (United States)

    Abramson, David H; Ji, Xunda; Francis, Jasmine H; Catalanotti, Federica; Brodie, Scott E; Habib, Larissa

    2018-06-06

    Ophthalmic artery chemosurgery (OAC) has changed the face of retinoblastoma treatment and led to a higher rate of globe salvage. The introduction of intravitreal chemotherapy (IVitC) has further enhanced globe salvage with increased success in treatment of intravitreal seeds. Our group has seen success at treating non-vitreous disease that is refractory to OAC using IVitC. This study was undertaken to quantify and report on this success. A retrospective review was used to identify patients treated with IVitC for indications other than vitreous seeds from two centres. The indication, prior and concurrent treatment, response time and duration of treatment were documented. Kaplan-Meier estimates were used to evaluate ocular and recurrence-free survival. Ocular toxicity was evaluated using the 30 Hz flicker electroretinogram (ERG). Continuous and categorical variables were compared with Student's t-test and χ 2 test, respectively. Fifty-six eyes from 52 retinoblastoma patients were identified. There were no disease-related or treatment-related deaths. One patient developed a second primary malignancy (pinealoblastoma) and subsequent leptomeningeal spread. Ninety-eight per cent of the eyes showed clinical regression. Recurrence was seen in 14.3%. Of the recurrences, five occurred in retinal tumours and three in subretinal seeds. The Kaplan-Meier estimated risk of recurrence in all patients treated was 83.5% (95% CI 7.9 to 14.1) at 10 months. The mean change in ERG over treatment course was -17.7 μV. Intravitreal chemotherapy is successful for the treatment of subretinal seeds and recurrent retinal tumours and could be considered as adjunctive therapy in globe-sparing treatment of retinoblastoma. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  4. Update on Intra-Arterial Chemotherapy for Retinoblastoma

    Directory of Open Access Journals (Sweden)

    Mario Zanaty

    2014-01-01

    Full Text Available The tools for managing retinoblastoma have been increasing in the past decade. While globe-salvage still relies heavily on intravenous chemotherapy, tumors in advanced stage that failed chemotherapy are now referred for intra-arterial chemotherapy (IAC to avoid enucleation. However, IAC still has many obstacles to overcome. We present an update on the indications, complications, limitations, success, and technical aspects of IAC. Given its safety and high efficacy, it is expected that IAC will replace conventional strategies and will become a first-line option even for tumors that are amenable for other strategies.

  5. In vitro Rb-1 gene transfer to retinoblastoma cell lines

    International Nuclear Information System (INIS)

    Choi, Sang Wook; Ham, Yong Hoh; Kim, Mee Heui

    1994-04-01

    After transfection of Rb-vector to packaging cell line (CRIP) by Ca-P precipitation method, we could select nineteen colonies of G-418 resistant clone by ring cloning. Each colony was transduced to NIH3T3 cells to select the one which produces high titer virus. After NIH3T3 cells transduction, we could get 28 colony counts for the high, 127 for the middle, and 6 for the low viral titer. With the supernatant of the high viral titer colony (CRIPRb 2-5). We transduct retinoblastoma cell lines. 5 figs, 11 refs. (Author)

  6. New research progress of microRNAs in retinoblastoma

    Directory of Open Access Journals (Sweden)

    Jing Zeng

    2014-11-01

    Full Text Available Retinoblastoma(RBis the most common intraocular malignancy of children with extremely poor prognosis. MicroRNAs are small non-coding single-stranded RNAs in eukaryotic cells, which regulate the expression of gene by mRNA degradation or translation inhibition. MicroRNAs, acting as oncogenes or tumor suppressor genes, are associated with the occurrence and development of RB directly, which is vital for the early diagnosis and clinical targeted therapy of RB. This review summarized the expression of microRNAs in RB and the related mechanism.

  7. Retinoblastoma in the Democratic Republic of Congo: 20-Year Review from a Tertiary Hospital in Kinshasa

    Directory of Open Access Journals (Sweden)

    Aimé Kazadi Lukusa

    2012-01-01

    Full Text Available Background. To determine clinical profile and management of retinoblastoma among children at Kinshasa in Democratic Republic of Congo. Patients and methods. The medical records of patients with a diagnosis of retinoblastoma seen at the University Hospital of Kinshasa from January 1985 till December 2005 were retrospectively reviewed. Demographic profile, clinical data, modes of treatment and outcome were analysed. Results. A total of 49 children, of whom 40 had adequate data on record were identified as retinoblastoma (28 males and 12 females. Nine cases had bilateral disease. The median age at the first symptoms was 9 months (range, 1 month to 6 years for unilateral retinoblastoma and 18 months (range, 1 month to 3.5 years for bilateral retinoblastoma. The median age at the first oncology consultation was 2.4 years (range, 6 months to 6 years for unilateral retinoblastoma and 2.4years (range, 9 months to 4 years for bilateral disease. Leukokoria was present in 67.5% of subjects. Seventy-five percent abandoned the treatment. The mortality was 92.5%. Conclusion. In Democratic Republic of Congo, retinoblastoma remains a life threatening disease characterized by late referral to a specialized unit and affordability of chemotherapy; all leading to an extension of the disease and high mortality.

  8. The toxic effects, GSH depletion and radiosensitivity by BSO on retinoblastoma

    International Nuclear Information System (INIS)

    Xianjin Yi; Li Ding; Yizun Jin; Chuo Ni; Wenji Wang

    1994-01-01

    Retinoblastoma is the most common intraocular malignant tumor in children. Previous investigations have reported that buthionine sulfoximine (BSO) can deplete intracellular glutathione (GSH) by specific inhibition and increase cellular radiosensitivity. The toxic effects, GSH depletion and radiosensitivity effects of BSO on retinoblastoma cells are reported in this paper. GSH content of retinoblastoma cell lines Y-79, So-Rb50 and retinoblastoma xenograft is 2.7 ± 1.3 X 1.0 -12 mmol/cell, 1.4 ± 0.2 X 1.0 -12 mmol/cell, and 2.8 ± 1.2 μmol/g, respectively. The ID 50 of BSO on Y-79 and So-Rb50 in air for 3 h exposure is 2.5 mM and 0.2 mM, respectively. GSH depletion by 0.1 mM BSO for 24 h on Y-79 cells and 0.01 mM BSO for 24 h on So-Rb50 cells is 16.35%, and 4.7% of control. GSH depletion in tumor and other organ tissues in retinoblastoma-bearing nude mice after BSO administration is differential. GSH depletion after BSO exposure in Y-79 cells in vitro decreases the Do value of retinoblastoma cells. The SER of 0.01 mM and 0.05 mM BSO for 24 h under hypoxic conditions is 1.21 and 1.36, respectively. Based on these observations, the authors conclude that BSO toxicity on retinoblastoma cells depends on the characteristics of the cell line and that BSO can increase hypoxic retinoblastoma cells' radiosensitivity in vitro. Further study of BSO radiosensitization on retinoblastoma in vivo using nude mouse xenografts is needed. 25 refs., 3 figs., 3 tabs

  9. The toxic effects, GSH depletion and radiosensitivity by BSO on retinoblastoma

    International Nuclear Information System (INIS)

    Yi Xianjin; Ni Chuo; Wang Wengi; Li Ding; Jin Yizun

    1993-01-01

    Retinoblastoma is the most common intraocular malignant tumor in children. Previous investigations have reported that buthionine sulfoximine (BSO) can deplete intracellular glutathione (GSH) by the specific inhibition and increase cellular radiosensitivity. The toxic effects, GSH depletion and radiosensitivity of BSO on retinoblastoma were reported. GSH content of retinoblastoma cell lines Y-79, So-Rb50 and retinoblastoma xenograft is (2.7 +- 1.3) x 10 -12 mmol/cell, (1.4 +- 0.2) x 10 -12 mmol/cell, and 2.8 +- 1.2 μmol/g respectively. The ID50 of BSO on Y-79 and So-Rb50 in air for 3h exposure is 2.5 mM and 0.2 mM respectively. GSH depletion by 0.1 mM BSO for 24h on Y-79 cells and 0.01 mM BSO for 24 h on So-Rb50 cells is 16.35%, and 4.7% of control. GSH depletion in tumor and other organ tissues in retinoblastoma bearing nude mice after BSO administration is differential. BSH depletion after BSO exposure in Y-79 cells in vitro decrease the D 0 value of retinoblastoma cells. The SER of 0.01 mM and 0.05 mM BSO for 24 h under the hypoxic condition is 1.21 and 1.36 respectively. Based on these observations, the authors conclude that BSO toxicity on retinoblastoma cells depends on the characteristics of cell line and BSO can increase hypoxic retinoblastoma cells radiosensitivity in vitro. Further study of BSO radiosensitization on retinoblastoma in vivo using nude mouse xenograft is needed

  10. Retinoblastoma incidence patterns in the US Surveillance, Epidemiology, and End Results program.

    Science.gov (United States)

    Wong, Jeannette R; Tucker, Margaret A; Kleinerman, Ruth A; Devesa, Susan S

    2014-04-01

    IMPORTANCE Several studies have found no temporal or demographic differences in the incidence of retinoblastoma except for age at diagnosis, whereas other studies have reported variations in incidence by sex and race/ethnicity. OBJECTIVE To examine updated US retinoblastoma incidence patterns by sex, age at diagnosis, laterality, race/ethnicity, and year of diagnosis. DESIGN, SETTING, AND PARTICIPANTS The Surveillance, Epidemiology, and End Results (SEER) databases were examined for retinoblastoma incidence patterns by demographic and tumor characteristics. We studied 721 children in SEER 18 registries, 659 in SEER 13 registries, and 675 in SEER 9 registries. MAIN OUTCOMES AND MEASURES Incidence rates, incidence rate ratios (IRRs), and annual percent changes in rates. RESULTS During 2000-2009 in SEER 18, there was a significant excess of total retinoblastoma among boys compared with girls (IRR, 1.18; 95% CI, 1.02 to 1.36), in contrast to earlier reports of a female predominance. Bilateral retinoblastoma among white Hispanic boys was significantly elevated relative to white non-Hispanic boys (IRR, 1.81; 95% CI, 1.22 to 2.79) and white Hispanic girls (IRR, 1.75; 95% CI, 1.11 to 2.91) because of less rapid decreases in bilateral rates since the 1990s among white Hispanic boys than among the other groups. Retinoblastoma rates among white non-Hispanics decreased significantly since 1992 among those younger than 1 year and since 1998 among those with bilateral disease. CONCLUSIONS AND RELEVANCE Although changes in the availability of prenatal screening practices for retinoblastoma may have contributed to these incidence patterns, further research is necessary to determine their actual effect on the changing incidence of retinoblastoma in the US population. In addition, consistent with other cancers, an excess of retinoblastoma diagnosed in boys suggests a potential effect of sex on cancer origin.

  11. Dosimetric Study of Current Treatment Options for Radiotherapy in Retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Eldebawy, Eman [Department of Radiation Oncology, McGill University Health Centre, Montreal, Quebec (Canada); Department of Radiation Oncology, Children' s Cancer Hospital, Cairo (Egypt); Parker, William, E-mail: william.parker@mcgill.ca [Department of Medical Physics, McGill University Health Centre, Montreal, Quebec (Canada); Abdel Rahman, Wamied [Department of Medical Physics, McGill University Health Centre, Montreal, Quebec (Canada); Freeman, Carolyn R. [Department of Radiation Oncology, McGill University Health Centre, Montreal, Quebec (Canada)

    2012-03-01

    Purpose: To determine the best treatment technique for patients with retinoblastoma requiring radiotherapy to the whole eye. Methods and Materials: Treatment plans for 3 patients with retinoblastoma were developed using 10 radiotherapy techniques including electron beams, photon beam wedge pair (WP), photon beam three-dimensional conformal radiotherapy (3D-CRT), fixed gantry intensity-modulated radiotherapy (IMRT), photon volumetric arc therapy (VMAT), fractionated stereotactic radiotherapy, and helical tomotherapy (HT). Dose-volume analyses were carried out for each technique. Results: All techniques provided similar target coverage; conformity was highest for VMAT, nine-field (9F) IMRT, and HT (conformity index [CI] = 1.3) and lowest for the WP and two electron techniques (CI = 1.8). The electron techniques had the highest planning target volume dose gradient (131% of maximum dose received [D{sub max}]), and the CRT techniques had the lowest (103% D{sub max}) gradient. The volume receiving at least 20 Gy (V{sub 20Gy}) for the ipsilateral bony orbit was lowest for the VMAT and HT techniques (56%) and highest for the CRT techniques (90%). Generally, the electron beam techniques were superior in terms of brain sparing and delivered approximately one-third of the integral dose of the photon techniques. Conclusions: Inverse planned image-guided radiotherapy delivered using HT or VMAT gives better conformity index, improved orbital bone and brain sparing, and a lower integral dose than other techniques.

  12. The success of primary chemotherapy for group D heritable retinoblastoma.

    Science.gov (United States)

    Cohen, V M L; Kingston, J; Hungerford, J L

    2009-07-01

    To report the ocular survival and event-free survival following primary multiagent chemotherapy for group D, heritable bilateral retinoblastoma (RB). The RB database was used to identify children with heritable, bilateral RB treated with primary chemotherapy (six cycles of vincristine, etoposide and carboplatin). Only Group D eyes with more than 12 months' follow-up were analysed. The timing, number and type of salvage treatments were recorded. Kaplan-Meier estimates for the ocular survival and event-free survival (percentage of eyes that avoided external beam radiotherapy and/or enucleation) were performed as a function of time. Of 18 group D eyes, two (11%) were treated successfully with chemotherapy alone, nine (50%) underwent successful salvage treatment, and seven (39%) were enucleated. The median time from completing chemotherapy to enucleation was 9 months (range 4 to 25 months). Ocular survival was 67% at 2 years. External beam radiotherapy proved successful salvage treatment in five of nine eyes, so the event-free survival was 34% at 2 years. Multiagent chemotherapy alone is rarely sufficient for the preservation of group D eyes. External beam radiotherapy and plaque radiotherapy remain important salvage treatments for advanced, heritable retinoblastoma.

  13. Chemotherapy as an adjuvant to Radiotherapy in treatment of Retinoblastoma

    International Nuclear Information System (INIS)

    Ahmed, A.H.M.

    2015-01-01

    Retinoblastoma is the most common primary intraocular malignancy of childhood. A potentially curable cancer, its treatment has improved significantly over the last few decades. Various studies show that while enucleation remains the standard of care for advanced intraocular tumours, conservative modalities that can result in globe salvage and preservation of useful vision are being increasingly employed. Such modalities include systemic chemotherapy, focal consolidation with transpupillary thermo therapy, laser photocoagulation and cryotherapy, plaque brachytherapy, and delivery of local chemotherapy using subconjunctival, sub-tenon, or intra-arterial routes. When used alone or in combination, these treatment modalities can help in avoidance of external beam radiotherapy or enucleation, thus reducing the potential for long-term side effects, while salvaging useful vision. Radioactive plaque brachytherapy has an established role in selected patients with intraocular retinoblastoma. Local injections of chemotherapeutic agents via the sub-tenon or sub-conjunctival route have been used with varying degrees of success, usually as an adjunct to systemic chemotherapy. Intra-arterial ophthalmic artery delivery of melphalan has shown promising results.

  14. Policonsumo simultáneo de drogas en estudiantes de facultades de ciencias de la salud/ciencias médicas en siete universidades de cinco países de América Latina y un país del Caribe: implicaciones de género, legales y sociales

    Directory of Open Access Journals (Sweden)

    Andrés Herrera Rodríguez

    2012-01-01

    Full Text Available El objetivo de este estudio fue comprender los patrones de policonsumo simultáneo de sustancias psicoactivas y sus implicaciones de género, legales y sociales, en estudiantes de primer y segundo año de las facultades de ciencias de la salud/ciencias médicas, en siete universidades de cinco países latinoamericanos, Colombia, Nicaragua, Chile, Brasil y El Salvador, y un país caribeño, Jamaica. El diseño fue un corte transversal. Las combinaciones de alcohol + tabaco y de alcohol + marihuana fueron las mas reportadas en todas las universidades, a excepción de alcohol + tabaco en Jamaica. Los factores asociados al policonsumo más referidos fueron "tener relaciones sexuales inesperada" en la universidad de Brasil, "tener relaciones sexuales sin protección" en las universidades de Chile, Colombia y Nicaragua, "tener problemas con su pareja sentimental" en la universidad de Jamaica, y "ausentarse de clases" en la universidad de El Salvador. Tres entornos se relacionaron, de manera positiva o negativa, con el policonsumo simultáneo de sustancias psicoactivas: estudiantil, familiar y de comportamiento sexual.

  15. The modality and results of complex treatment of extended retinoblastoma in children

    International Nuclear Information System (INIS)

    Belkina, B.M.; Durnov, L.A.; Polyakov, V.G.; Goldobenko, G.V.; Glekov, I.V.; Ushakova, T.L.

    1997-01-01

    Analysis of the results of combined treatment of retinoblastoma in children according to the program developed in the Scientific and Research Institute of Pediatric Oncology and Hematology is performed. The treatment program permits to avoid in many cases the unjustified removal of eye. Combination of treatment methods (surgery, radiotherapy and chemotherapy) and their sequence depends on the classification by stages of retinoblastoma development according to the TNM system. Five year survival in case of monoretinoblastoma with surgical operation at the first stage and without is 92% and 82% corresponding while in case of double retinoblastoma - 83% and 84%

  16. Sobre las implicaciones normativas de la neurociencia social

    OpenAIRE

    Salles, Arleen

    2013-01-01

    En las últimas décadas, la neurociencia y la psicología cognitiva nos ha permitido comenzar a entender la relación entre procesos psicológicos diversos y hasta sobre las bases neurológicas de las creencias, las emociones, los juicios y las decisiones morales. Pese a la aceptada distinción entre el carácter descriptivo de la ciencia y el normativo de la moralidad, algunos autores afirman que los resultados de los estudios neurocientíficos tienen implicaciones normativas. No es c...

  17. Novel function of the retinoblastoma protein in fat: regulation of white versus brown adipocyte differentiation

    DEFF Research Database (Denmark)

    Hansen, Jacob B; te Riele, Hein; Kristiansen, Karsten

    2004-01-01

    the major energy store and brown adipocytes being potent energy-dissipaters through thermogenesis. Yet, little is known about factors differentially regulating the formation of white and brown fat cells. Members of the retinoblastoma protein family (pRB, p107, p130) have been implicated in the regulation...... of adipocyte differentiation, and expression and phosphorylation of the three retinoblastoma family proteins oscillate in a characteristic manner during differentiation of the white preadipocyte cell line 3T3-L1. We have recently demonstrated a surprising function of the retinoblastoma protein...... in the regulation of white versus brown adipocyte differentiation in vitro and possibly in vivo. Here we summarize the current knowledge on the retinoblastoma protein in fat cells, with particular emphasis on its potential role in adipocyte lineage commitment and differentiation....

  18. La mecánica cuántica de David Bohm: formalismo matemático e implicaciones epistemológicas

    Directory of Open Access Journals (Sweden)

    Rodrigo Siqueira-Batista

    2014-11-01

    Full Text Available La interpretación bohmiana de la Mecánica Cuántica representa una de las principales alternativas al modelo hegemónico propuesto por la Escuela de Copenhague, permitiendo una descripción determinista de los eventos ocurridos a nivel cuántico. El objetivo del presente artículo es presentar sucintamente sus principales aspectos matemáticos y conceptuales —y sus respectivas implicaciones epistemológicas.

  19. Tratamento conservador em retinoblastoma intra-ocular Conservative treatment for intraocular retinoblastoma

    Directory of Open Access Journals (Sweden)

    Clélia Maria Erwenne

    2003-12-01

    bilaterais foram conservados 48,9% dos olhos tratados. Entre os unilaterais, para os mesmos estádios obteve-se: I 0/0; II 2/2 (100,0%; III 1/3 (33,3%; IV 1/3 (33,3%; V 0/7 (0%. Considerando-se o total de unilaterais foram conservados 26,6% dos olhos. Não se observou nefro ou ototoxicidade às drogas neste grupo.PURPOSE: To report the results of conservation of the ocular globe after treatment with carboplatin and laser; with or without the use of other forms of local treatment or radiotherapy, if necessary. METHODS: All eyes, initially untreated, were evaluated using indirect ophthalmology under inhalation anesthesia in an outpatient clinic treatment setting. They were categorized according to the Reese-Ellsworth system; thereafter, the patients were evaluated clinically by a pediatric oncologist. The patients received the first cycle of chemotherapy consisting of intravenous carboplatin 200 mg/m², vincristine 1.5 mg/m² and etoposide 150 mg/m², for three days. This was followed by other cycles with intervals of between 21 and 28 days. From 7 to 15 days after the end of the chemotherapy cycle, another indirect ophthalmoscopy under inhalation anesthesia was performed, with documentation of the findings and laser hyperthermia application, using a Diode laser, 810 nm, continuous pulse with a large spot size. The procedure (chemotherapy and laser was repeated until complete cicatrization of all lesions was observed, or until the need for another treatment modality such as radiotherapy or enucleation became apparent. Follow-up examinations every two months during the first year and three months thereafter were done for review and for treatment of recurrent or new lesions. Pediatric oncology follow-up was also done throughout the entire initial assessment and follow-up period. RESULTS: We treated a total of 62 patients with retinoblastoma, of whom 32 were male and 30 female. Fifteen were unilateral and 47 were bilateral with a total of 107 eyes. The mean age was 16.9 months (2

  20. Breaking down barriers to communicating complex retinoblastoma information: can graphics be the solution?

    Science.gov (United States)

    Chiu, Hannah H; Dimaras, Helen; Downie, Rob; Gallie, Brenda

    2015-06-01

    To investigate the impact of a graphical timeline summarizing bilateral retinoblastoma disease and treatment outcomes on parents' understanding of complex medical information. Cross-sectional survey. Parents of children with retinoblastoma who were being actively managed at The Hospital for Sick Children were recruited. Forty-five parents from 42 families participated. After a standardized presentation on retinoblastoma and visual tool named Disease-Specific electronic Patient Illustrated Clinical Timeline (DePICT), parents completed a 19-item questionnaire designed to assess their understanding of treatment choices for 2 eyes in bilateral retinoblastoma as communicated using DePICT. SPSS was used to perform statistical analysis. Forty-five parents from 42 families participated (65% female). Median age of participants was 34 years. Median level of participant education was completion of college/trade school. The median level of annual income was $40,000 to $70,000 CDN. Median time since diagnosis of retinoblastoma in their child was 13.5 months. Twenty-three (51%) participants were parents of children with unilateral retinoblastoma, and 22 (49%) were parents of children with bilateral retinoblastoma. Median number of correct answers was 15 of 19, and mean score was 77%. Normal distribution of scores was noted. English as a first language was significantly associated with score (p = 0.01). No significant association was observed between other variables and score in all analyses. This study builds on the validation of DePICT by demonstrating that parents can achieve good comprehension even when considering choices for treatment for 2 eyes with bilateral retinoblastoma. Clinical application of this tool can enhance the consent process. Copyright © 2015 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

  1. burnout y estrategias de inteligencia emocional en profesores universitarios: implicaciones en la salud laboral educativa

    Directory of Open Access Journals (Sweden)

    Betsy Ilaja

    2016-01-01

    Full Text Available Diversos estudios sitúan a la docencia universitaria como una de las profesiones con mayor riesgo a experimentar inestabilidad y estrés laboral. La presente investigación exploró el ni- vel de burnout y las habilidades en inteligencia emocional en una muestra de 60 profesores universitarios de tiempo completo de la Pontificia Universidad Católica del Ecuador, sede Ambato. Se realizaron análisis de mediación múltiple y se encontró que: a las tareas de in- vestigación y vinculación se asocian significativamente a burnout, y la tarea de docencia es percibida como desempeño óptimo, b la salud actúa como variable mediadora entre estrés laboral y burnout, y el género solo se relaciona con burnout, y c la regulación emocional media la relación entre desempeño docente y satisfacción laboral. Se discuten las implicaciones de estos hallazgos en la salud laboral de docentes universitarios.

  2. Sister chromatid exchange induced by X-irradiation of retinoblastoma lymphocytes

    International Nuclear Information System (INIS)

    Abramovsky-Kaplan, I.; Jones, I.S.

    1984-01-01

    Lymphocyte cultures were employed to assess the degree of spontaneous and induced chromosomal fragility in retinoblastoma. Sister chromatid exchange (SCEs) were scored in metaphases. Three unilateral, three bilateral, eleven family members and controls were studied. Retinoblastoma (RB) lymphocytes did not exhibit increased spontaneous fragility. X-irradiation (25-200 rad) did not significantly increase SCE in unilateral retinoblastoma lymphocytes when compared with controls (P greater than 0.50). However, bilaterally affected subjects and three unaffected relatives demonstrated a statistically significant increase in SCE (P less than 0.01). In conclusion, hereditary retinoblastoma lymphocytes appear more radiosensitive than sporadic retinoblastoma, perhaps, reflecting the increased second malignancies in germinal mutation retinoblastoma. In addition, the analysis of radiation-induced SCE in peripheral blood lymphocytes of RB patients and family members may provide a valuable tool increasing the accuracy of genetic counseling for this disorder. Additional studies of RB patients and families are needed to assess the relevance of this approach to genetic counseling

  3. Radiation regression patterns after cobalt plaque insertion for retinoblastoma

    International Nuclear Information System (INIS)

    Buys, R.J.; Abramson, D.H.; Ellsworth, R.M.; Haik, B.

    1983-01-01

    An analysis of 31 eyes of 30 patients who had been treated with cobalt plaques for retinoblastoma disclosed that a type I radiation regression pattern developed in 15 patients; type II, in one patient, and type III, in five patients. Nine patients had a regression pattern characterized by complete destruction of the tumor, the surrounding choroid, and all of the vessels in the area into which the plaque was inserted. This resulting white scar, corresponding to the sclerae only, was classified as a type IV radiation regression pattern. There was no evidence of tumor recurrence in patients with type IV regression patterns, with an average follow-up of 6.5 years, after receiving cobalt plaque therapy. Twenty-nine of these 30 patients had been unsuccessfully treated with at least one other modality (ie, light coagulation, cryotherapy, external beam radiation, or chemotherapy)

  4. Radiation regression patterns after cobalt plaque insertion for retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Buys, R.J.; Abramson, D.H.; Ellsworth, R.M.; Haik, B.

    1983-08-01

    An analysis of 31 eyes of 30 patients who had been treated with cobalt plaques for retinoblastoma disclosed that a type I radiation regression pattern developed in 15 patients; type II, in one patient, and type III, in five patients. Nine patients had a regression pattern characterized by complete destruction of the tumor, the surrounding choroid, and all of the vessels in the area into which the plaque was inserted. This resulting white scar, corresponding to the sclerae only, was classified as a type IV radiation regression pattern. There was no evidence of tumor recurrence in patients with type IV regression patterns, with an average follow-up of 6.5 years, after receiving cobalt plaque therapy. Twenty-nine of these 30 patients had been unsuccessfully treated with at least one other modality (ie, light coagulation, cryotherapy, external beam radiation, or chemotherapy).

  5. A pilot study of hyperfractionated radiotherapy for infants with retinoblastoma

    International Nuclear Information System (INIS)

    Harris, Eleanor E.R.; Meadows, Anna T.; Shields, Jerry; D'Angio, Giulio J.; Goldwein, Joel W.

    1996-01-01

    Purpose: This study was undertaken to assess the use of twice daily fractionated radiotherapy using low doses per fraction in the treatment of intraocular retinoblastoma in infants in terms of local control, ocular complications and bony growth disturbances. Methods: Children were irradiated using standard techniques including en face electrons (3 patients) or opposed lateral photon fields to one or both orbits (7 patients). Patients were treated with 100 cGy twice daily with an inter fraction interval of 4 or more hours to total doses of 43 to 45 Gy. No patients received chemotherapy. Results: Ten children under the age of 13 months were entered onto the twice daily radiation protocol from 4/87 through 6/90. Nine patients presented with nonfamilial bilateral retinoblastoma; one later failed in the pineal region representing trilateral retinoblastoma. The tenth patient had advanced unilateral disease. Of 19 eyes involved with tumor, 13 were group V and all patients had at least one eye with advanced disease (group III-V). Two patients underwent enucleation of the more advanced eye up front and received radiation to the intact eye only. Overall survival was 8 of 10 patients with a median follow-up of 28 months (range 12-47 months). Two patients died of distant metastases, one with local recurrence and one with trilateral disease but local control. Local recurrence after initial external beam radiation therapy only was seen in 8 of 19 eyes (42%). Failures occurred in 6 of 13 group V eyes, 1 of 2 group IV eyes and 1 of 2 group III eyes. Further local therapy included plaque therapy in 3 eyes, cryotherapy in 3 eyes and enucleation in one eye. Surgery was refused for one patient with bilateral recurrences. Ultimate local control after external beam irradiation plus additional local therapies was 16 of 19 eyes (84%). Post-irradiation ocular loss occurred in 5 of 19 eyes. Therefore, overall local control with ocular preservation was achieved in 14 of 19 eyes (74%). Vision

  6. Treatment of retinoblastoma by precision megavoltage radiation therapy

    International Nuclear Information System (INIS)

    Schipper, J.; Peperzeel, H.A. van; Tan, K.E.W.P.

    1985-01-01

    The principal treatment concept in the Utrecht Retinoblastoma Centre is megavoltage irradiation, followed by light coagulation and/or cryotherapy if there is any doubt as to whether the residual tumour is still active. Radiation therapy is administered by means of a simple but highly accurate temporal beam technique. A standardized dose of 45 Gy is given in 15 fractions of 3 Gy at 3 fractions per week. From 1971 to 1982, 39 children with retinoblastoma have been irradiated in at least one eye. Of the 73 affected eyes, 18 were primarily enucleated, one received light coagulation only, and 54 received radiation therapy. Of the 54 irradiated eyes, 32 were additionally treated by light coagulation and/or cryotherapy for suspicious residual tumour (in 29 eyes), recurrent tumour (in 1 eye), and/or new tumour (in 3 eyes) and 10 were ultimately enucleated. Two eyes also received hyperthermia. The percentages of cure of the irradiated eyes with a minimum follow-up of 2 years were 100% (14/14), 100% (9/9,) 83% (10/12), 79% (11/14) and 0% (0/5) in the Reese-Ellsworth groups I to V-A, respectively. Of the saved eyes 95% achieved useful vision. Eighteen eyes developed a clinically detectable radiation cataract; in five of these the lens was aspirated. Cataracts developed exclusively in those lenses of which a posterior portion of more than 1 mm had to be included in the treatment field. The likelihood and the degree of cataract formation was found to be directly related to the dose of radiation to the germinative zone of the lens epithelium. The minimum cataractogenic dose found in this series was 8 Gy. (Auth.)

  7. Treatment of retinoblastoma by precision megavoltage radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Schipper, J.; Peperzeel, H.A. van (Rijksuniversiteit Utrecht (Netherlands). Academisch Ziekenhuis); Tan, K.E.W.P. (Royal Dutch Eye Hospital, Utrecht, Netherlands)

    1985-02-01

    The principal treatment concept in the Utrecht Retinoblastoma Centre is megavoltage irradiation, followed by light coagulation and/or cryotherapy if there is any doubt as to whether the residual tumour is still active. Radiation therapy is administered by means of a simple but highly accurate temporal beam technique. A standardized dose of 45 Gy is given in 15 fractions of 3 Gy at 3 fractions per week. From 1971 to 1982, 39 children with retinoblastoma have been irradiated in at least one eye. Of the 73 affected eyes, 18 were primarily enucleated, one received light coagulation only, and 54 received radiation therapy. Of the 54 irradiated eyes, 32 were additionally treated by light coagulation and/or cryotherapy for suspicious residual tumour (in 29 eyes), recurrent tumour (in 1 eye), and/or new tumour (in 3 eyes) and 10 were ultimately enucleated. Two eyes also received hyperthermia. The percentages of cure of the irradiated eyes with a minimum follow-up of 2 years were 100% (14/14), 100% (9/9), 83% (10/12), 79% (11/14) and 0% (0/5) in the Reese-Ellsworth groups I to V-A, respectively. Of the saved eyes 95% achieved useful vision. Eighteen eyes developed a clinically detectable radiation cataract; in five of these the lens was aspirated. Cataracts developed exclusively in those lenses of which a posterior portion of more than 1 mm had to be included in the treatment field. The likelihood and the degree of cataract formation was found to be directly related to the dose of radiation to the germinative zone of the lens epithelium. The minimum cataractogenic dose found in this series was 8 Gy.

  8. Optimized lens-sparing treatment of retinoblastoma with electron beams

    International Nuclear Information System (INIS)

    Steenbakkers, Roel J.H.M.; Altschuler, Martin D.; D'Angio, Giulio J.; Goldwein, Joel W.; Kassaee, Alireza

    1997-01-01

    Purpose: The ideal lens-sparing radiotherapy technique for retinoblastoma calls for 100% dose to the entire retina including the ora serrata and zero dose to the lens. Published techniques, most of which use photons, have not accomplished this ideal treatment. We describe here a technique that approaches this ideal configuration using electron beam therapy. Methods and Materials: Dose-modeling calculations were made using a computer program built around a proprietary algorithm. This program calculates 3D dose distribution for electrons and photons and uses the Cimmino feasibility method for the inverse problem of beam weighting to achieve the prescribed dose. The algorithm has been verified in the ocular region by measurements in a RANDO phantom. To search for an ideal lens-sparing beam setup, a stylized phantom of an 8-month-old infant was generated with built-in inhomogeneities, and a phantom of a 5-year-old child was generated from a patient CT series. Results: Of more than 100 different beam setups tested, two 9 MeV electron beams at gantry angles plus and minus 26 degrees from the optic nerve axis achieved the best distribution. Both fields have a lens block and an isocenter between the globe and origin of the optic nerve. When equal doses are given to both fields, the entire extent of the retina (including ora serrata) received 100%, while the lens received 10% or less. Conclusion: The two-oblique-electron-beam technique here described appears to meet most of the stringent dosimetry needed to treat retinoblastoma. It is suitable for a range of ages, from infancy to early childhood years

  9. LA NECESIDAD DE REACTIVACIÓN DEL CRECIMIENTO DE LAS SOCIEDADES LABORALES Y LA REFORMA DE SU LEGISLACIÓN: ANÁLISIS ECONÓMICO-FINANCIERO DE SUS PRINCIPALES IMPLICACIONES / THE NECESSITY OF REACTIVATION OF THE GROWTH OF THE LABOR MANAGED FIRMS AND THE LAW REFORM: ANALYSIS OF ECONOMIC AND FINANCIAL MAIN IMPLICATIONS

    Directory of Open Access Journals (Sweden)

    Sonia MARTÍN LÓPEZ

    2010-04-01

    Full Text Available La crisis económica actual ha debilitado el tejido empresarial español reduciéndose el número de nuevas iniciativas empresariales que se ponen en marcha. Las Sociedades Laborales, no han sido ajenas a los efectos de la citada crisis, y por tanto, también han visto ralentizado el ritmo de nuevas constituciones. No obstante, en el caso de las Sociedades Laborales no sólo es importante analizar la incidencia de la crisis económica, sino que existen otra serie de factores ajenos a la misma que precipitaron su declive antes de que los efectos de la crisis tuvieran su reflejo en la economía española. A lo largo de este trabajo se pretende, una vez estudiados los factores expuestos anteriormente y su incidencia en la evolución y constitución de nuevas sociedades, analizar las implicaciones económicas y financieras más relevantes que podrían tener tanto en las propias Sociedades Laborales y en su evolución futura, como en sus trabajadores, socios y no socios, con contrato indefinido, las principales propuestas elaboradas por CONFESAL (Confederación Empresarial de Sociedades Anónimas Laborales de España de cara a la próxima reforma de su legislación./ The current economic crisis has affected the Spanish enterprises, and the number of new enterprise initiatives that start up has reduced. The Labour Managed Firms have seen slowed down the rate of new constitutions. However, in the case of the Labour Managed Firms not only it is important to analyze the incidence of the economic crisis, but another factors which precipitated their declivity before the arrival of crisis effects. Throughout this work it is tried, once studied the set out factors previously and their incidence in the evolution and constitution of new societies, to analyze the economic and financial implications more important in the own Labour Managed Firms and their future evolution, like in their workers, partners and nonpartners, with indefinite contract, the main

  10. Clinical presentation of retinoblastoma in Alexandria: A step toward earlier diagnosis.

    Science.gov (United States)

    Soliman, Sameh E; Eldomiaty, Wesam; Goweida, Mohamed B; Dowidar, Amgad

    2017-01-01

    To evaluate the clinical presentation of retinoblastoma in Alexandria, Egypt, correlate the timing of accurate diagnosis with the presence of advanced disease and identify causes of delayed presentation. Retrospective noncomparative single institution study reviews demographic and clinical data of all new children with retinoblastoma presenting to Alexandria Main University ocular oncology clinic (OOC) from January 2012 to June 2014. Diagnosis time was from initial parental complaint to retinoblastoma diagnosis and referral time was from retinoblastoma diagnosis to presentation to the Alexandria OCC. Delayed Diagnosis and referral were counted if >2 weeks. Advanced presentation is defined as clinical TNMH (8th edition) staging of cT2 or cT3 (international intraocular retinoblastoma classification group D or E) in at least one eye or the presence of extra-ocular disease (cT4). Seventy eyes of 47 children were eligible: 52% unilateral, 7% with family history and 96% presented with leukocorea. Sixty-four percent of children had advanced intraocular disease and none had extra-ocular disease. Delayed presentation occurred in 58% of children and was significantly associated with advanced disease in both unilaterally and bilaterally affected children (p = 0.003, 0.002 respectively). The delay in diagnosis was more in unilateral cases while the delay in referral was more in bilateral cases. The main cause of delayed presentation in unilateral retinoblastoma was misdiagnosis (30%) while parental shopping for second medical opinion (30%) was the main cause in bilateral children. Delayed diagnosis is a problem affecting retinoblastoma management. Better medical education and training, health education and earlier screening are recommended to achieve earlier diagnosis.

  11. Colorimetric and longitudinal analysis of leukocoria in recreational photographs of children with retinoblastoma.

    Directory of Open Access Journals (Sweden)

    Alireza Abdolvahabi

    Full Text Available Retinoblastoma is the most common primary intraocular tumor in children. The first sign that is often reported by parents is the appearance of recurrent leukocoria (i.e., "white eye" in recreational photographs. A quantitative definition or scale of leukocoria--as it appears during recreational photography--has not been established, and the amount of clinical information contained in a leukocoric image (collected by a parent remains unknown. Moreover, the hypothesis that photographic leukocoria can be a sign of early stage retinoblastoma has not been tested for even a single patient. This study used commercially available software (Adobe Photoshop® and standard color space conversion algorithms (operable in Microsoft Excel® to quantify leukocoria in actual "baby pictures" of 9 children with retinoblastoma (that were collected by parents during recreational activities i.e., in nonclinical settings. One particular patient with bilateral retinoblastoma ("Patient Zero" was photographed >7, 000 times by his parents (who are authors of this study over three years: from birth, through diagnosis, treatment, and remission. This large set of photographs allowed us to determine the longitudinal and lateral frequency of leukocoria throughout the patient's life. This study establishes: (i that leukocoria can emerge at a low frequency in early-stage retinoblastoma and increase in frequency during disease progression, but decrease upon disease regression, (ii that Hue, Saturation and Value (i.e., HSV color space are suitable metrics for quantifying the intensity of retinoblastoma-linked leukocoria; (iii that different sets of intraocular retinoblastoma tumors can produce distinct leukocoric reflections; and (iv the Saturation-Value plane of HSV color space represents a convenient scale for quantifying and classifying pupillary reflections as they appear during recreational photography.

  12. La formación integral en Dios como fundamento del desarrollo personal y social

    OpenAIRE

    Flórez Luna, Carlos Alberto

    2015-01-01

    Este texto pretende mostrar la importancia de una formación integral basada en principios morales y espirituales que orienten al individuo hacia el desarrollo armonioso del ser, teniendo en cuenta las diferentes dimensiones del ser humano. Por lo tanto, se abordan de manera directa el concepto de formación integral y sus implicaciones en el contexto social.

  13. Violencia de Pareja en Mujeres Hispanas: Implicaciones para la Investigación y la Práctica

    Science.gov (United States)

    Gonzalez-Guarda, Rosa Maria; Becerra, Maria Mercedes

    2012-01-01

    Las investigaciones sobre la violencia entre parejas sugieren que las mujeres hispanas están siendo afectadas desproporcionadamente por la ocurrencia y consecuencias de este problema de salud pública. El objetivo del presente artículo es dar a conocer el estado del arte en relación a la epidemiologia, consecuencias y factores de riesgo para VP entre mujeres Hispanas, discutiendo las implicaciones para la investigación y la práctica. Investigaciones han demostrado una fuerte asociación del status socioeconómico, abuso de droga y el alcohol, la salud mental, aculturación, inmigración, comportamientos sexuales riesgosos e historia de abuso con la violencia entre parejas. Sin embargo, más estudios se deben llevar a cabo para identificar otros factores de riesgos y de protección a poblaciones hispanas no clínicas. Mientras que el conocimiento sobre la etiología de la VP entre mujeres Hispanas se expanda, enfermeras y otros profesionales de la salud deben desarrollar, implementar y evaluar estrategias culturalmente adecuadas para la prevención primaria y secundaria de la violencia entre pareja. PMID:26166938

  14. Reforma, cultura democrática y transversalidad Implicaciones en la relación universidad-sociedad

    Directory of Open Access Journals (Sweden)

    Suleima Bustamante Uzcátegui

    2007-05-01

    Full Text Available El propósito de este estudio es analizar los procesos de:reforma, diversidad, cultura democrática y transversalidad, y sus implicaciones en la relación universidad y sociedad. Estudio que se realiza bajo la modalidad del paradigma crítico reflexivo, en tanto que el nuevo ordenamiento social hace de las universidades, entidades más complejas, de variadas funciones, de mayor consumo de recursos, diluyendo su identidad en nuevas perspectivas. Se evidencia al currículo como el eje central del proceso de reforma, centrado en valores, el cual abre la posibilidad de abordar aspectos vitales tanto individual como grupal, transferibles a la sociedad en su conjunto. La reforma implica la diversidad y la transversalidad, reflejada en la concreción de un conjunto de medidas y de acciones, que reconoce la heterogeneidad de los grupos, de los valores, de la solidaridad, la tolerancia y el respeto a lo individual. La discusión revela el compromiso de las universidades para desarrollar un profundo trabajo epistemológico de investigación y redefinición de su actuar, como mecanismo para conectar los saberes a la complejidad del tejido de una realidad impregnada por los cambios, la complementariedad y la multiculturalidad.

  15. Efectos musculares y hematológicos del uso de rHuEpo en combinación con el entrenamiento físico. Implicaciones de la demospresina y la hipoxia en el dopaje sanguineo. Estudios in vivo e in vitro.

    OpenAIRE

    Martínez Bello, Vladimir Essau

    2011-01-01

    En la presente Tesis Doctoral hemos querido estudiar, en primer lugar, el efecto que tendría el incremento artificial de la capacidad de transporte de oxígeno, a través del tratamiento con rHuEpo, sobre distintos parámetros musculares así como su implicación en la mejora del rendimiento físico. Son muchos los autores que, tanto en el ámbito clínico (Winearls, Oliver y cols. 1986; Bommer, Muller-Buhl y cols. 1987) como en el ámbito deportivo (Berglund y Ekblom 1991; Lundby, Robach y cols. 2008...

  16. Símbolos, fórmulas, imágenes y palabras: sus implicaciones en la enseñanza y el aprendizaje de la estequiometria: estudio de caso en grado x de la Institución Educativa Barrio Santa Margarita del Municipio de Medellín

    OpenAIRE

    Alvarez, Gustavo Adolfo

    2011-01-01

    Este proyecto presenta una alternativa viable y aplicable para el desarrollo y la mejora del proceso enseñanza-aprendizaje de la estequiometria de 10º grado de educación básica; que mejoraría el desarrollo mental, estimulando el pensamiento crítico en los educandos, en la búsqueda de presentar propuestas para solucionar problemas cotidianos y éticos presentes en la realidad social del educando. Con el presente trabajo se pretende ayudar a mejorar el proceso enseñanza aprendizaje de la este...

  17. La problematica de la demarcacion entre ciencia y pseudociencia y sus implicaciones en la educacion cientifica

    Science.gov (United States)

    Jimenez Tolentino, Dinorah

    2011-12-01

    En la sociedad prevalece una tendencia generalizada hacia la inclusion de creencias y practicas pseudocientificas. Esta investigacion responde a la necesidad de analizar como la proliferacion de las pseudociencias afecta la vision que tienen los estudiantes universitarios sobre las ciencias naturales. A tales efectos, la investigadora describe las concepciones epistemologicas que tienen los estudiantes sobre las ciencias y las pseudociencias e identifica los criterios de demarcacion, entre un area y otra, que se derivan de estas concepciones. De igual modo, esta identifica las creencias y practicas pseudocientificas de mayor arraigo entre los estudiantes, destacando, a su vez, la razon de ser de las mismas. Por ultimo, la investigadora analiza las implicaciones educativas de la problematica de la demarcacion entre ciencia y pseudociencia. La investigacion es de naturaleza mixta, enmarcada en los paradigmas empirico- analitico y cualitativo. El proceso investigativo se llevo a cabo mediante la administracion del cuestionario Criterios para la demarcacion entre ciencia y pseudociencia. La parte cualitativa estuvo enmarcada en el diseno de estudio de caso, recopilando informacion mediante entrevistas semiestructuradas en dos grupos focales. La poblacion de estudio estuvo constituida por estudiantes universitarios del nivel subgraduado de la Universidad Central de Bayamon. Los resultados del estudio reflejaron las concepciones erroneas de los estudiantes sobre la naturaleza de las ciencias y las pseudociencias. Con respecto a la demarcacion entre ciencia y pseudociencia, el criterio imperante entre los universitarios es el de la verificabilidad, considerando la aplicacion del metodo cientifico como el metodo para demostrar la veracidad de las teorias cientificas. Las creencias y practicas pseudocientificas no son muy frecuentes entre los universitarios. Estos atribuyen las mismas a la prevalencia de elementos supersticiosos y al engano a que es sometida la poblacion

  18. Epidemiologic Study of Retinoblastoma in Recife, Pernambuco - Brazil: January 1985 - July 1997 Estudo Epidemiológico do Retinoblastoma no Recife - Pernambuco - Brasil: janeiro 1985 - julho 1997

    Directory of Open Access Journals (Sweden)

    Armando Anderson Abreu

    1999-10-01

    Full Text Available Background: Retinoblastoma is by far the most frequent malignant intraocular tumor of childhood. This study was performed to characterize the clinical, diagnostic, treatment and prognostic aspects in patients with retinoblastoma in three reference centers for this pathology in the city of Recife, Pernambuco - Brazil. Methods: A consecutive series of 85 patients with retinoblastoma was reviewed. The authors selected 66 patients (77.6% that fulfilled the inclusion criteria for these study. Results: Of a total of 66 patients with retinoblastoma, 4.5% had a previous history of the disease in the family. Males were more affected than females at a ratio (male/female of 1.12. The mean age of appearance of the first symptoms was 23.8 months, with leukocoria and ocular hyperemia being the most frequent. The mean age at time of diagnosis was 31.7 months and for surgical treatment 32.8 months. The right eye was affected in 42.4% of the cases and the left was involved in 37.9% of cases. The tumor was unilateral in 80.3% and bilateral in 19.7% of the cases. There was extraocular involvement in 62.1%, and it was intraocular in 37.9% of the patients. Treatment was surgery combined with chemotherapy in 47.0% of the patients. 27.3% of the patients died and 19.7% abandoned the treatment. Conclusions: The data on the epidemiology of retinoblastoma found in our city resembles that of other developing countries, concerning the epidemioloy of retinoblastoma.Objetivo: O retinoblastoma é o tumor maligno intraocular mais freqüente da infância. O objetivo deste estudo foi avaliar aspectos clínicos, de diagnóstico, tratamento e prognóstico em pacientes portadores de retinoblastoma atendidos em três centros de referência para esta patologia na cidade do Recife - PE. Métodos: Revisamos 85 prontuários de portadores de retinoblastoma e apresentamos o resultado da análise de 66 destes pacientes, atendidos durante o período de janeiro de 1985 a julho de 1997

  19. Postenucleation orbits in retinoblastoma: treatment with 125I brachytherapy

    International Nuclear Information System (INIS)

    Stannard, Clare; Sealy, Ross; Hering, Egbert; Hough, Jan; Knowles, Ruth; Lecuona, Karin; Reddi, V. Bala

    2002-01-01

    Purpose: Children with retinoblastoma that extends into or through the choroid, sclera, or optic nerve are at risk of developing orbital disease, as well as metastases. Previously, these enucleated orbits were treated with external beam radiotherapy in addition to chemotherapy. 125 I brachytherapy for tumors in and around the eye was pioneered by Sealy in Cape Town, South Africa, in 1974. In 1983, he developed a technique to irradiate the contents of the orbit while limiting the dose to the bony orbit and eyelids. Methods and Materials: Six nylon tubes containing 125 I seeds were implanted through the eyelids around the periphery of the orbit. Each contained a metal gutter that screens the outer part of the seeds from the bony orbit. A seventh unscreened tube was placed in the center, and a metal disc with 125 I seeds on its posterior surface was secured beneath the eyelids. Between 1983 and 2000, 57 orbits were treated in 56 children with retinoblastoma. Thirty-six were treated prophylactically and 21, with tumor at the resection line of the nerve, extrascleral tumor, or metastases, were treated therapeutically. They received a median dose of 34 Gy in 70 h; 30 also received chemotherapy. Children with tumor at the resection line of the nerve also received treatment to the craniospinal axis. Results: The median follow-up of the 35 patients treated prophylactically was 35 months (range 0-187). Seven patients died, 6 of metastases, at a median of 10 months (range 4-29) after the implant. Eight of the 13 patients with microscopic extraocular tumor survived a median of 29 months (range 5-156). None of the 8 patients presenting with orbital tumor or metastases survived. No orbital recurrences developed in any of the patients. Cosmesis was considerably improved compared with previous forms of irradiation. Conclusion: Orbital brachytherapy is an effective method of irradiating the orbit to prevent recurrent tumor, the treatment time is short, and the cosmesis is much more

  20. Psychosocial factors influencing parental decision to allow or refuse potentially lifesaving enucleation in children with retinoblastoma

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    Rolando Enrique D. Domingo

    2017-01-01

    Full Text Available Objective: Retinoblastoma is the most common malignancy of the eye and ocular adnexa in the Philippines. It is curable when treated early, but delay in enucleation is common due to the parental refusal of surgery for varied reasons. The aim of this study is to identify the psychosocial barriers and facilitating factors for accepting versus refusing enucleation as treatment for retinoblastoma. Methods: This is a cross-sectional descriptive study utilizing structured interviews and a questionnaire. It was conducted at the Retinoblastoma Clinic of the Philippine General Hospital. A questionnaire using the Likert scale was constructed after performing key informant interviews and focus group discussions. It was pretested and revised before parents of patients with retinoblastoma were invited to participate in the study. Descriptive statistics, quantitative item analyses using inter-item correlations and item-total correlations was performed. Results: Factors that correlate with refusal to enucleate are the beliefs that cancer is a fatal illness, the fear of unacceptable esthetic outcome of the surgery, and the cost of treatment. Favorable factors include value of life, high regard for the opinion of medical practitioners, and appreciation of the efficacy of treatment. Conclusions: There are several favorable factors and barriers that health practitioners must consider in facilitating parental decision-making toward enucleation for retinoblastoma.

  1. EL PARADIGMA ENERGÉTICO DE LOS BIOCOMBUSTIBLES Y SUS IMPLICACIONES: PANORAMA MUNDIAL Y EL CASO COLOMBIANO

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    CASTIBLANCO ROZO CARMENZA

    2012-12-01

    Full Text Available Normal 0 21 false false false ES-CO X-NONE X-NONE MicrosoftInternetExplorer4 Ante la necesidad mundial por encontrar fuentes de energía alternativas, los biocombustibles se han constituido en la última década como una posible respuesta. Su creciente demanda se ha visto reflejada en la expansión de los cultivos utilizados como materias primas, lo cual tiene implicaciones en varios frentes: los cambios de uso de la tierra, servicios ecosistémicos relacionados con el recurso hídrico, las emisiones de Gases Efecto Invernadero (GEI, la seguridad alimentaria y la propiedad de la tierra. El presente artículo tiene como objetivo presentar un análisis crítico de estos temas a partir de la revisión de la literatura internacional y abordar el caso colombiano, en particular la expansión de los cultivos de palma africana y sus implicaciones sociales. Los principales resultados dejan ver que la expansión de los cultivos se direccionará hacia los países del trópico, lo cual genera  impactos negativos al intensificar la competencia por el agua y la tierra en regiones caracterizadas por su alta vulnerabilidad ecosistémica y social. Adicionalmente se observa la necesidad de mejorar los sistemas de información y de refinar metodologías y modelos que permitan evaluar con mayor precisión los impactos de la producción de biocombustibles sobre el bienestar humano.

  2. Texturas de los minerales del grupo de la sílice de la manifestación epitermal El Rifle-Hato Viejo, región de Moa: clasificación, descripción e implicaciones genéticas

    Directory of Open Access Journals (Sweden)

    Leduar Ramayo-Cortés

    2001-03-01

    Full Text Available En el marco de la región de Moa, Cuba oriental, se localizan varias manifestaciones hidrotermales. Se trata de sistemas vetiformes y brechas hidrotermales con contenidos significativos de metales nobles. La manifestación hidrotermal El Rifle-Hato Viejo se destaca por su extensión, y está formada por brechas y vetas de cuarzo mineralizadas, vinculadas preferentemente a fracturas correspondientes al sistema de fallas NW-SE y se hospeda en rocas sedimentarias del Campaniense Tardío-Daniense. El estudio textural de los minerales del grupo de la sílice permitió el reconocimiento de varias texturas, las cuales fueron clasificadas en tres grupos: 1 texturas de crecimiento primario (calcedonia maciza, costriforme, en peine, cristales zonados, y maciza, 2 texturas de recristalización (mosaico, plumosa y llameante, y 3 texturas de reemplazo (en enrejado, paralelo y radiado. Sobre la base de este análisis se estableció la secuencia deposicional de los diferentes minerales del grupo de la sílice y se reveló la presencia de la paragénesis de alteración adularia-sericita, lo cual indicaría el desarrollo de un sistema epitermal de baja sulfuración. Estas texturas también se usaron para indicar el nivel de emplazamiento dentro del sistema epitermal; en este caso, el emplazamiento de la manifestación El Rifle-Hato Viejo se corresponde con el nivel intermedio o coloiforme-costriforme, el cual se encuentra por encima de la zona propicia para la deposición del oro, por lo que podría esperarse la presencia de contenidos más elevados en profundidad.

  3. LA LIBRE COMPETENCIA ECONÓMICA EN EL DERECHO COLOMBIANO: UNA REVISIÓN DESDE LA ECONOMÍA SOCIAL DE MERCADO Y SUS IMPLICACIONES NORMATIVAS

    Directory of Open Access Journals (Sweden)

    Andrea Alarcón Peña

    2016-01-01

    Full Text Available El artículo consigna un ejercicio de revisión jurídica sobre las características del modelo de economía social de mercado, reconocido como modelo económico por la Corte Constitucional, dentro del subsistema constitucional económico colombiano. l a primera parte del escrito de - talla las particularidades e implicaciones de este modelo y las consecuencias que su estructura supone para la libre competencia económica, habida consideración del marco normativo de protección. Posteriormente, se describen las generalidades de los sistemas de protección del derecho a la competencia anglosajón y europeo tomando como referencia las normas más importantes en cada uno de ellos, con el fin de comprender el impacto que dichos sistemas tuvieron en el modelo colombiano. Por último se presentan las propiedades más relevantes del régimen de protección de competencia en Colombia a partir de un bosquejo general del marco normativo existente.

  4. The genetic alteration of retinoblastoma gene in esophageal cancer

    International Nuclear Information System (INIS)

    Cho, Jae Il; Shim, Yung Mok; Kim, Chang Min

    1994-12-01

    Retinoblastoma(RB) gene is the prototype of tumor suppressor gene and it's alteration have been frequently observed in a large number of human tumors. To investigate the role of RB in esophageal cancer, we studied 36 esophageal cancer tissues with Southern blot analysis to detect gross LOH and PCR-SSCP method to find minute LOH and mutation, if any. In the cases with abnormalities, the nucleotide sequence analysis was performed. Allelic loss of chromosome 13q14 occurred in 20 out of 32 informative cases (62.5%) by Southern analysis. Furthermore, PCR-LOH added three positive cases. Mobility shift by PCR-SSCP was observed in one case at exon 22, which showed 1 bp deletion in codon 771 of RB gene resulting in frame shift mutation. Besides, nine PCR-band alteration in tumor tissue compared with normal tissue were observed in exon 14 and 22, but mutation was not found on sequencing analysis suggesting the epigenetic alteration in tumor tissue. Analysis of the clinical data did not show any difference depending upon RB alteration. However, the total incidence of RB gene may play an important role in the development of esophageal cancer. The main genetic alteration of RB gene was deletion detected by Southern blot and one bp deletion leading to frame shift was also observed. 8 figs, 5 tabs. (Author)

  5. [Eyeball salvage treatment or enucleation for advanced retinoblastoma].

    Science.gov (United States)

    Qian, J; Xue, K

    2016-10-11

    The management of retinoblastoma (RB) has dramatically changed over the past two decades. The introduction of chemotherapy has transformed treatment algorithms completely. Chemotherapy is currently used as a first line approach for children with RB and can be delivered by intravenous, intra-arterial and intravitreal routes. However, there still remains some controversy on the treatment of advanced RB, especially in eyeball salvage. This article described domestic and international approaches to eyeball salvage treatment. We would like to further discuss our opinion on the management of advanced RB based on our clinical experience for attracting more clinical concern on this issue. Many factors should be considered when choosing the appropriate conservative therapy. The choice of eyeball salvage treatment not only depends upon the tumor staging and laterality but also upon compliance and economic factors. Doctors and parents should not blindly pursue eye saving. However, there are still cases where enucleation is definitely the treatment of choice. (Chin J Ophthalmol, 2016, 52: 728-732) .

  6. Retinoblastoma: Achieving new standards with methods of chemotherapy

    Directory of Open Access Journals (Sweden)

    Swathi Kaliki

    2015-01-01

    Full Text Available The management of retinoblastoma (RB has dramatically changed over the past two decades from previous radiotherapy methods to current chemotherapy strategies. RB is a remarkably chemotherapy-sensitive tumor. Chemotherapy is currently used as a first-line approach for children with this malignancy and can be delivered by intravenous, intra-arterial, periocular, and intravitreal routes. The choice of route for chemotherapy administration depends upon the tumor laterality and tumor staging. Intravenous chemotherapy (IVC is used most often in bilateral cases, orbital RB, and as an adjuvant treatment in high-risk RB. Intra-arterial chemotherapy (IAC is used in cases with group C or D RB and selected cases of group E tumor. Periocular chemotherapy is used as an adjunct treatment in eyes with group D and E RB and those with persistent/recurrent vitreous seeds. Intravitreal chemotherapy is reserved for eyes with persistent/recurrent vitreous seeds. In this review, we describe the various forms of chemotherapy used in the management of RB. A database search was performed on PubMed, using the terms "RB," and "treatment," "chemotherapy," "systemic chemotherapy," "IVC," "IAC," "periocular chemotherapy," or "intravitreal chemotherapy." Relevant English language articles were extracted, reviewed, and referenced appropriately.

  7. Expression and clinical significance of Pax6 gene in retinoblastoma

    Directory of Open Access Journals (Sweden)

    Hai-Dong Huang

    2013-07-01

    Full Text Available AIM: To discuss the expression and clinical significance of Pax6 gene in retinoblastoma(Rb. METHODS: Totally 15 cases of fresh Rb organizations were selected as observation group and 15 normal retinal organizations as control group. Western-Blot and reverse transcriptase polymerase chain reaction(RT-PCRmethods were used to detect Pax6 protein and Pax6 mRNA expressions of the normal retina organizations and Rb organizations. At the same time, Western Blot method was used to detect the Pax6 gene downstream MATH5 and BRN3b differentiation gene protein level expression. After the comparison between two groups, the expression and clinical significance of Pax6 gene in Rb were discussed. RESULTS: In the observation group, average value of mRNA expression of Pax6 gene was 0.99±0.03; average value of Pax6 gene protein expression was 2.07±0.15; average value of BRN3b protein expression was 0.195±0.016; average value of MATH5 protein expression was 0.190±0.031. They were significantly higher than the control group, and the differences were statistically significant(PCONCLUSION: Abnormal expression of Pax6 gene is likely to accelerate the occurrence of Rb.

  8. The genetic alteration of retinoblastoma gene in esophageal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Jae Il; Shim, Yung Mok; Kim, Chang Min [Korea Cancer Center Hospital of Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1994-12-01

    Retinoblastoma(RB) gene is the prototype of tumor suppressor gene and it`s alteration have been frequently observed in a large number of human tumors. To investigate the role of RB in esophageal cancer, we studied 36 esophageal cancer tissues with Southern blot analysis to detect gross LOH and PCR-SSCP method to find minute LOH and mutation, if any. In the cases with abnormalities, the nucleotide sequence analysis was performed. Allelic loss of chromosome 13q14 occurred in 20 out of 32 informative cases (62.5%) by Southern analysis. Furthermore, PCR-LOH added three positive cases. Mobility shift by PCR-SSCP was observed in one case at exon 22, which showed 1 bp deletion in codon 771 of RB gene resulting in frame shift mutation. Besides, nine PCR-band alteration in tumor tissue compared with normal tissue were observed in exon 14 and 22, but mutation was not found on sequencing analysis suggesting the epigenetic alteration in tumor tissue. Analysis of the clinical data did not show any difference depending upon RB alteration. However, the total incidence of RB gene may play an important role in the development of esophageal cancer. The main genetic alteration of RB gene was deletion detected by Southern blot and one bp deletion leading to frame shift was also observed. 8 figs, 5 tabs. (Author).

  9. Dosimetric intercomparison between protons and electrons therapies applied to retinoblastoma

    International Nuclear Information System (INIS)

    Braga, Flavia Vieira

    2008-01-01

    In this work we propose a construction of a simple human eye model in order to simulate the dosimetric response for a treatment with protons and electrons in a retinoblastoma cancer. The computational tool used in this simulation was the Geant4 code, in the version 4.9.1, all these package are free and permit simulate the interaction of radiation with matter. In our simulation we use a box with 4 cm side, with water, for represent the human eye. The simulation was performed considering mono energetics beams of protons and electrons with energy range between 50 and 70 MeV for protons and 2 and 10 MeV for electrons. The simulation was based on the advanced hadron therapy example of the Geant 4 code. In these example the phantom is divided in voxels with 0.2 mm side and it is generated the energy deposited in each voxel. The simulation results show the energy deliver in each voxel, with these energie we can calculate the dose deposited in that region. We can see the dose profile of, proton and electron, and we can see in both cases that for protons the position of delivered dose is well know, that happen in the position where the proton stop, for electrons the energies is delivered along the way and pass the desired position for high dose deposition. (author)

  10. Retinoblastoma loss modulates DNA damage response favoring tumor progression.

    Directory of Open Access Journals (Sweden)

    Marcos Seoane

    Full Text Available Senescence is one of the main barriers against tumor progression. Oncogenic signals in primary cells result in oncogene-induced senescence (OIS, crucial for protection against cancer development. It has been described in premalignant lesions that OIS requires DNA damage response (DDR activation, safeguard of the integrity of the genome. Here we demonstrate how the cellular mechanisms involved in oncogenic transformation in a model of glioma uncouple OIS and DDR. We use this tumor type as a paradigm of oncogenic transformation. In human gliomas most of the genetic alterations that have been previously identified result in abnormal activation of cell growth signaling pathways and deregulation of cell cycle, features recapitulated in our model by oncogenic Ras expression and retinoblastoma (Rb inactivation respectively. In this scenario, the absence of pRb confers a proliferative advantage and activates DDR to a greater extent in a DNA lesion-independent fashion than cells that express only HRas(V12. Moreover, Rb loss inactivates the stress kinase DDR-associated p38MAPK by specific Wip1-dependent dephosphorylation. Thus, Rb loss acts as a switch mediating the transition between premalignant lesions and cancer through DDR modulation. These findings may have important implications for the understanding the biology of gliomas and anticipate a new target, Wip1 phosphatase, for novel therapeutic strategies.

  11. Autologous fat graft in irradiated orbit postenucleation for retinoblastoma.

    Science.gov (United States)

    Klinger, Francesco; Maione, Luca; Vinci, Valeriano; Lisa, Andrea; Barbera, Federico; Balia, Laura; Caviggioli, Fabio; Di Maria, Alessandra

    2018-01-05

    Autologous fat grafting has been extensively and successfully adopted in a number of pathologic conditions in regenerative surgery especially on irradiated fields in order to improve pain symptoms and tissue trophism promoting scar release. In the present study, we report our experience with autologous fat grafting for the treatment of postirradiation fibrosis and pain on three consecutive patients undergoing orbital enucleation for locally advanced retinoblastoma (RB) and subsequent radiotherapy. We selected three consecutive patients who underwent orbital enucleation for locally advanced RB and subsequent local radiotherapy showing severe reduction in orbital volume and eyelid length and retraction due to fibrosis, spontaneous local pain exacerbated after digital pressure with no possibility to place an ocular implant. They underwent autologous fat grafting in the orbital cavity and results were evaluated by clinical examination at 5 and 14 days, and 1, 3, 6 months, and 1 year after surgery. A significant release of scar retraction, reduction of fibrosis and orbital rim contraction together with an important improvement of pain symptoms was observed in all patients. The local changes observed enabled an ease placement of an ocular prosthetic implant (implant). No local or systemic complication occurred. Fat grafting is a promising treatment for patients showing radiotherapy related complication in the orbital area and it should be adopted by all oculoplastic surgeon in order to improve pain syndrome creating the ideal local conditions for the placement of an ocular prosthetic implant.

  12. Structure and expression of the Xenopus retinoblastoma gene.

    Science.gov (United States)

    Destrée, O H; Lam, K T; Peterson-Maduro, L J; Eizema, K; Diller, L; Gryka, M A; Frebourg, T; Shibuya, E; Friend, S H

    1992-09-01

    We have cloned a Xenopus homology (XRb1) of the human retinoblastoma susceptibility gene. DNA sequence analysis shows that the XRb1 gene product is highly conserved in many regions. The leucine repeat motif and many of the potential cdc2 phosphorylation sites, as well as potential sites for other kinases, are retained. The region of the protein homologous to the SV40 T antigen binding site and the basic region directly C-terminal to the E1A binding site are all conserved. XRb1 gene expression at the RNA level was studied by Northern blot analysis. Transcripts of 4.2 and 10-kb are present as maternal RNA stores in the oocyte. While the 4.2-kb product is stable until at least the mid-blastula stage, the 10-kb transcript is selectively degraded. Between stages 11 and 13 the 10-kb transcript reappears and also a minor product of approximately 11 kb becomes apparent. Both the 4.2- and the 10-kb transcripts remain present until later stages of development and are also present in all adult tissues examined, although at differing levels. Antibodies raised against human p105Rb which recognize the protein product of the XRb1 gene, pXRb1, detect the Xenopus 99-kDa protein prior to the mid-blastula stage, but at lower levels than at later stages in development.

  13. LAS COMUNICACIONES INTEGRADAS DE MARKETING (CIM COMO PILAR DE LA ESTRATEGIA DE MARKETING VERDE Y SUS IMPLICACIONES EN LA GESTIÓN AMBIENTAL

    Directory of Open Access Journals (Sweden)

    NELCY ROCÍO ESCOBAR MORENO

    2012-01-01

    Full Text Available Este documento examina el constructo de Comunicaciones Integradas de Marketing (CIM, desde su definición hasta su aplicación a partir de la perspectiva del mercadeo verde en la estrategia organizacional. El texto presenta tres grandes discusiones, primero, una reflexión particular sobre los aportes e implicaciones más importantes de las Comunicaciones Integradas de Marketing y de cada uno de sus instrumentos a la estrategia de gestión ambiental de las organizaciones. Luego, una caracterización general del consumidor verde y de otros stakeholders de la organización, en particular, de su papel en el proceso estratégico de la comunicación verde. Finalmente, como conclusión de este trabajo, se plantean algunas consideraciones sobre la necesaria aplicación de este concepto en la propuesta de gestión ambiental organizacional en la actualidad.

  14. Estudio comparativo de las decisiones de los magistrados del Tribunal Supremo español y los resultados de estudios empíricos sobre las implicaciones psicológicas en menores en situación de guarda y custodia compartida

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    Marta Marín

    2017-01-01

    Full Text Available Se toma como referencia la modificación de la Ley 15/2005 en el Código Civil español, donde se introduce el concepto de guarda y custodia compartida por primera vez en España. El objetivo del presente trabajo es establecer si existe una relación entre los resultados de las investigaciones con base empírica y las decisiones judiciales acerca de los efectos que producen en menores la guarda y custodia compartidas. Para ello se ha realizado un análisis cualitativo de las investigaciones relativas a las consecuencias de la custodia compartida, tanto a nivel nacional como internacional. Posteriormente, se han comparado los resultados de las investigaciones con las decisiones de los magistrados, obtenidas tras realizar un análisis de la jurisprudencia de las sentencias del Tribunal Supremo desde el año 2005 hasta el año 2015.

  15. Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma.

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    Justina McEvoy

    Full Text Available Retinoblastoma is a childhood cancer of the developing retina that begins in utero and is diagnosed in the first years of life. Biallelic RB1 gene inactivation is the initiating genetic lesion in retinoblastoma. The p53 gene is intact in human retinoblastoma but the pathway is believed to be suppressed by increased expression of MDM4 (MDMX and MDM2. Here we quantify the expression of MDM4 and MDM2 mRNA and protein in human fetal retinae, primary retinoblastomas, retinoblastoma cell lines and several independent orthotopic retinoblastoma xenografts. We found that MDM4 is the major p53 antagonist expressed in retinoblastoma and in the developing human retina. We also discovered that MDM4 protein steady state levels are much higher in retinoblastoma than in human fetal retinae. This increase would not have been predicted based on the mRNA levels. We explored several possible post-transcriptional mechanisms that may contribute to the elevated levels of MDM4 protein. A proportion of MDM4 transcripts are alternatively spliced to produce protein products that are reported to be more stable and oncogenic. We also discovered that a microRNA predicted to target MDM4 (miR191 was downregulated in retinoblastoma relative to human fetal retinae and a subset of samples had somatic mutations that eliminated the miR-191 binding site in the MDM4 mRNA. Taken together, these data suggest that post-transcriptional mechanisms may contribute to stabilization of the MDM4 protein in retinoblastoma.

  16. Repair and replication of DNA in hereditary (bilateral) retinoblastoma cells after X-irradiation

    International Nuclear Information System (INIS)

    Cleaver, J.E.; Char, D.; Charles, W.C.; Rand, N.

    1982-01-01

    Fibroblasts from patients with hereditary retinoblastoma reportedly exhibit increased sensitivity to killing by X-rays. Although some human syndromes with similar or greater hypersensitivity to DNA-damaging agents (e.g., X-rays, ultraviolet light, and chemical carcinogens), such as xeroderma pigmentosum, are deficient in DNA repair, most do not have such clearly demonstrable defects in repair. Retinoblastoma cells appear to be normal in repairing single-strand breaks and performing repair replication after X-irradiation and also in synthesizing poly(adenosine diphosphoribose). Semiconservative DNA replication in these cells, however, is slightly more resistant than normal after X-irradiation, suggesting that continued replication of damaged parental DNA could contribute to the pathogenesis of the disease. This effect is small, however, and may be a consequence rather than a cause of the fundamental enzymatic abnormality in retinoblastoma that causes the tumorigenesis

  17. Multicultura e interculturalidad: implicaciones de una ausencia en la educación

    Directory of Open Access Journals (Sweden)

    Fernando Carlos Aguero-Contreras

    2016-06-01

    Full Text Available Resumen Reflexión teórica desde las perspectivas sociológica – antropológica de la educación, sustentada en los enfoques de la multicultura e interculturalidad. Se parte de varios estudios realizados en la residencia estudiantil de la Universidad de Cienfuegos, al centro - sur de Cuba. Estos han combinados análisis cuantitativos y cualitativos, considerando variables e indicadores socio demográficos, relacionados con la satisfacción en el acceso a la cultura, la salud, las relaciones y dinámicas sociales, mediadas por una estructura social clasista y sociocultural que distingue especificidades en la biografía cultural de individuos y grupos. Se concedió importancia a la significación dada a la residencia como escenario relevante de la vida educacional, las percepciones de las relaciones múltiples y diversas entre los grupos que tienen presencia en ella, así como los niveles de diálogos en los ámbitos académicos, científicos y sociales. Se analizaron varios documentos, y se realizaron observaciones, entrevistas estructuradas y en profundidad. Desde este contexto se muestran las implicaciones del déficit teórico en la gestión formativa en la residencia universitaria, limitando el alcance del proyecto educativo como concreción curricular, para el desarrollo de procesos socializadores más coherentes. Se concluye que la ausencia de estas perspectivas teóricas en la educación superior posibilitaron que la visión política ocupara la primera interpretación del proceso, expresada en la acción solidaria y aun cuando se muestran resultados concretos de importancia en cuanto al número de alumnos graduados, el proceso formativo fue limitado en el diálogo profundo, la socialización cultural para la lograr la unidad en la diversidad.

  18. Los valores éticos y sus implicaciones en la gestión administrativa

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    Edith Rodriguez

    2016-11-01

    Full Text Available El objetivo de esta investigación es determinar los valores éticos que poseen los estudiantes de cuarto curso de Administración de Empresas de la Universidad de Guayaquil y sus implicaciones en la Gestión Administrativa. El problema se genera a partir de las observaciones realizadas por la autora de este artículo, a los estudiantes de la Carrera de Gestión Empresarial de la Facultad de Ciencias Administrativas de la Universidad de Guayaquil en los procesos de clase. La metodología utilizada corresponde a un estudio de campo de tipo descriptivo y explicativo, se utilizó un instrumento de recolección de datos tipo encuesta fue aplicado a una población constituida por 120 estudiantes de la carrera de gestión empresarial. Los resultados del estudio  evidenciaron un bajo nivel en el cumplimiento de los códigos de ética por parte de los estudiantes, la relación entre las variables de investigación resultó ser positiva muy débil, lo que significa que mientras el estudiante mejore el cumplimiento de la ética en su actividad áulica, se evidenciará en estos un mejor  desempeño profesional. La investigación concluye proponiendo una serie de estrategias a fin de proporcionar al estudiante la posibilidad de participación a cursos de capacitación, talleres o charlas donde se compartan conocimientos entre los integrantes de la universidad, planificados y organizados por la carrera.

  19. Regional and temporal differences in gene expression of LH(BETA)T(AG) retinoblastoma tumors.

    Science.gov (United States)

    Houston, Samuel K; Pina, Yolanda; Clarke, Jennifer; Koru-Sengul, Tulay; Scott, William K; Nathanson, Lubov; Schefler, Amy C; Murray, Timothy G

    2011-07-23

    The purpose of this study was to evaluate by microarray the hypothesis that LH(BETA)T(AG) retinoblastoma tumors exhibit regional and temporal variations in gene expression. LH(BETA)T(AG) mice aged 12, 16, and 20 weeks were euthanatized (n = 9). Specimens were taken from five tumor areas (apex, anterior lateral, center, base, and posterior lateral). Samples were hybridized to gene microarrays. The data were preprocessed and analyzed, and genes with a P 2.5 were considered to be differentially expressed. Differentially expressed genes were analyzed for overlap with known networks by using pathway analysis tools. There were significant temporal (P regional differences in gene expression for LH(BETA)T(AG) retinoblastoma tumors. At P 2.5, there were significant changes in gene expression of 190 genes apically, 84 genes anterolaterally, 126 genes posteriorly, 56 genes centrally, and 134 genes at the base. Differentially expressed genes overlapped with known networks, with significant involvement in regulation of cellular proliferation and growth, response to oxygen levels and hypoxia, regulation of cellular processes, cellular signaling cascades, and angiogenesis. There are significant temporal and regional variations in the LH(BETA)T(AG) retinoblastoma model. Differentially expressed genes overlap with key pathways that may play pivotal roles in murine retinoblastoma development. These findings suggest the mechanisms involved in tumor growth and progression in murine retinoblastoma tumors and identify pathways for analysis at a functional level, to determine significance in human retinoblastoma. Microarray analysis of LH(BETA)T(AG) retinal tumors showed significant regional and temporal variations in gene expression, including dysregulation of genes involved in hypoxic responses and angiogenesis.

  20. Rhegmatogenous retinal detachment in an eye of retinoblastoma treated by radiation and cryocoagulation

    International Nuclear Information System (INIS)

    Inoue, Makoto; Tanaka, Yasuhiko; Kawai, Masataka; Nii, Seiji; Katsura, Hiroshi; Kaneko, Akihiro

    1999-01-01

    A 4-month-old female infant was diagnosed as bilateral retinoblastoma. The left eye was treated by enucleation and the right by radiation. The right eye received repeated thermochemotherapy, cryocoagulation and photocoagulation for recurrence. Total retinal detachment was detected after surgery for complicated cataract at the age of 2 years 9 months. Vitreous surgery led to the detection of posterior vitreous detachment and retinal breaks in the coagulated scar areas with vitreoretinal adhesion around the calcified tumor. During the following one year, the retina has been attached with no reoccurrence of the tumor. This case illustrates that rhegmatogenous retinal detachment is a possibility in retinoblastoma treated by radiation or retinal coagulations. (author)

  1. Retinoblastoma: experience of a referral center in the North Region of Portugal

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    Rocha-Bastos R

    2014-05-01

    Full Text Available RA da Rocha-Bastos,1 JR Araújo,1 RS Silva,2 MJ Gil-da-Costa,2 E Brandão,1 NJ Farinha,2,3 F Falcão-Reis,1,4 T Dinah-Bragança1 1Department of Ophthalmology, Hospital São João, 2Hematology and Oncology Unit, Pediatric Hospital, Hospital São João, 3Pediatrics Department, Faculty of Medicine, University of Porto, 4Department of Sense Organs, Faculty of Medicine, University of Porto, Porto, Portugal Purpose: To describe the experience of the Ophthalmology Department of Hospital São João (HSJ, a tertiary health care center in North Region, Portugal, in terms of the diagnosis, treatment, and follow-up of retinoblastoma. Methods: This was a retrospective study of patients diagnosed with retinoblastoma in Hospital São João, between 1978 and 2012. Results: Fifty patients with retinoblastoma were evaluated in our institution between 1978 and 2012. Four patients were excluded due to loss of follow-up. Among the 46 retinoblastoma cases, 33 (71.7% were unilateral and 13 (28.3% bilateral, with a mean age at diagnosis of 22.19 months and 6.92 months, respectively (P<0.001. Leukocoria was the most common presenting sign (36.9%, followed by strabismus (19.6%, a combination of leukocoria and strabismus (8.7%, and buphthalmia (2.2%. Between 1978 and 1992, nine retinoblastoma cases were referred to our hospital, all of them unilateral, and, in each case, enucleation was performed, with or without salvage therapy. Between 1993 and 2012, 18 eyes with retinoblastoma were successfully managed with conservative treatment. Conclusion: Demographic results were generally coincident with previous reports. It is crucial to screen leukocoria in pediatric practice, even in asymptomatic children. The outcome of retinoblastoma treatment in our hospital is similar to other series in developed countries. Keywords: retinoblastoma, leukocoria, strabismus, enucleation, pediatric cancer

  2. Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis

    DEFF Research Database (Denmark)

    Tort, F.; Bartkova, J.; Sehested, M.

    2006-01-01

    culture models with differential defects of retinoblastoma pathway components, as overexpression of cyclin D1 or lack of p16(Ink4a), either alone or combined, did not elicit detectable DDR. In contrast, inactivation of pRb, the key component of the pathway, activated the DDR in cultured human or mouse...... with their hierarchical positions along the retinoblastoma pathway. Our data provide new insights into oncogene-evoked DDR in human tumorigenesis, with potential implications for individualized management of tumors with elevated cyclin D1 versus cyclin E, due to their distinct clinical variables and biological behavior....

  3. Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation

    DEFF Research Database (Denmark)

    Hansen, Jacob B; Jørgensen, Claus; Petersen, Rasmus K

    2004-01-01

    Adipocyte precursor cells give raise to two major cell populations with different physiological roles: white and brown adipocytes. Here we demonstrate that the retinoblastoma protein (pRB) regulates white vs. brown adipocyte differentiation. Functional inactivation of pRB in wild-type mouse embryo...... fibroblasts (MEFs) and white preadipocytes by expression of simian virus 40 large T antigen results in the expression of the brown fat-specific uncoupling protein 1 (UCP-1) in the adipose state. Retinoblastoma gene-deficient (Rb-/-) MEFs and stem cells, but not the corresponding wild-type cells, differentiate...

  4. Schedule-Dependent Antiangiogenic and Cytotoxic Effects of Chemotherapy on Vascular Endothelial and Retinoblastoma Cells.

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    Ursula Winter

    Full Text Available Current treatment of retinoblastoma involves using the maximum dose of chemotherapy that induces tumor control and is tolerated by patients. The impact of dose and schedule on the cytotoxicity of chemotherapy has not been studied. Our aim was to gain insight into the cytotoxic and antiangiogenic effect of the treatment scheme of chemotherapy used in retinoblastoma by means of different in vitro models and to evaluate potential effects on multi-drug resistance proteins. Two commercial and two patient-derived retinoblastoma cell types and two human vascular endothelial cell types were exposed to increasing concentrations of melphalan or topotecan in a conventional (single exposure or metronomic (7-day continuous exposure treatment scheme. The concentration of chemotherapy causing a 50% decrease in cell proliferation (IC50 was determined by MTT and induction of apoptosis was evaluated by flow cytometry. Expression of ABCB1, ABCG2 and ABCC1 after conventional or metronomic treatments was assessed by RT-qPCR. We also evaluated the in vivo response to conventional (0.6 mg/kg once a week for 2 weeks and metronomic (5 days a week for 2 weeks topotecan in a retinoblastoma xenograft model. Melphalan and topotecan were cytotoxic to both retinoblastoma and endothelial cells after conventional and metronomic treatments. A significant decrease in the IC50 (median, 13-fold; range: 3-23 was observed following metronomic chemotherapy treatment in retinoblastoma and endothelial cell types compared to conventional treatment (p0.05. In mice, continuous topotecan lead to significantly lower tumor volumes compared to conventional treatment after 14 days of treatment (p<0.05. Continuous exposure to melphalan or topotecan increased the chemosensitivity of retinoblastoma and endothelial cells to both chemotherapy agents with lower IC50 values compared to short-term treatment. These findings were validated in an in vivo model. None of the dosing modalities induced

  5. [Treatment modalities and results of comprehensive therapy for extended retinoblastoma in children].

    Science.gov (United States)

    Belkina, B M; Durnov, L A; Poliakov, V G; Goldobenko, G V; Glekov, I V; Ushakova, T L

    1997-01-01

    New procedures of laser therapy and chemotherapy have extended the scope of application of organ-saving treatment at advanced stages of retinoblastoma in childhood, thus making it possible to preserve the eye fully functional or cosmetic. Not having to perform such mutilating procedures as ophthalmectomy or eye socket exenteration contributes to psychological and physical rehabilitation. At the same time, as a comparison of the results of surgery carried out at initial stages and surgery-free treatment showed that palliative therapy is characterized by impressive rates of 5-year survival. New vistas have opened of in the management of pediatric retinoblastoma, particularly in cases of stage III tumor and bilateral involvement.

  6. Diversidad genética de Plasmodium falciparum y sus implicaciones en la epidemiología de la malaria.

    Directory of Open Access Journals (Sweden)

    Judy Natalia Jiménez

    2005-12-01

    Full Text Available La diversidad genética le confiere a Plasmodium falciparum la capacidad de evadir la respuesta inmune del hospedero y producir variantes resistentes a medicamentos y a vacunas, aspectos que juegan un papel importante en el establecimiento de medidas de control contra la malaria. Diferentes autores han documentado la existencia de diversas cepas o clones de P. falciparum, cuya diversidad genética se ha confirmado a través de distintos ensayos de PCR (reacción en cadena de la polimerasa. Numerosas investigaciones realizadas en poblaciones con diferente grado de transmisión de malaria han mostrado la relación existente entre la estructura de la población de P. falciparum y la epidemiología de la enfermedad. En este artículo se describen las fases del ciclo de vida en las que los eventos de recombinación originan la diversidad genética de P. falciparum, se revisan los estudios realizados sobre este aspecto en regiones con diferentes grados de endemicidad, así como sobre sus implicaciones en la adquisición de inmunidad y en el desarrollo de medidas de control.

  7. Teoría de los marcos relacionales: algunas implicaciones para la psicopatología y la psicoterapia

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    Serafín Gómez-Martín

    2007-01-01

    Full Text Available El objetivo de este estudio teórico es destacar las posibilidades aplicadas de la Teoría de los Marcos Relacionales (RFT en el ámbito clínico. En primer lugar, describiremos de manera muy breve algunos de los principales conceptos técnicos de la teoría (por ejemplo, los conceptos de transformación de funciones y de operante generalizada. Posteriormente, propondremos cuatro causas por las cuales se generan los problemas psicológicos derivadas de una aproximación a la psicopatología humana generada desde la RFT. Dichas causas tienen que ver con los contextos verbales de la literalidad, la formación de categorías y por consiguiente la evaluación y comparación, el contexto de la búsqueda de coherencia y de dar razones y finalmente con el control de los eventos privados. Por último, se expondrán las amplias implicaciones clínicas de los conceptos de contexto relacional y contexto funcional, usando ejemplos clínicos relevantes y clasificando diferentes terapias en función de cual es su objetivo principal: la alteración del contexto funcional o del contexto relacional de redes relacionales.

  8. Implicaciones del VIH/SIDA en la biografía de varones con prácticas homoeróticas en la Ciudad de México Implications of AIDS on the biography of men with homoerotics practices in Mexico City

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    Gabriel Gallego-Montes

    2010-04-01

    Full Text Available OBJETIVO: Determinar los cambios en la configuración biográfica de un conjunto de varones con prácticas homoeróticas en la era del sida. MATERIAL Y MÉTODOS: Se aplicó una encuesta retrospectiva durante el primer semestre de 2006 a una muestra intencional de 250 varones en la Ciudad de México. Con ellos fue posible reconstruir 633 historias de pareja ocurridas en diferentes momentos del tiempo. Por otro lado, tomando como base el comportamiento epidemiológico del VIH/SIDA en México, se construyeron tres cohortes de emparejamiento: "antes del sida" 1970-1984; 1985-1995 o periodo de "crecimiento exponencial" y 1996-2005 o de "estabilización" de la epidemia. RESULTADOS: Durante el periodo en estudio se encontró una menor exclusividad sexual y una menor duración en las relaciones de pareja, entre cohortes de emparejamientos. Este proceso ha sido documentado en otros lugares y se le ha llamado de "distensión sexual". CONCLUSIONES: El estudio aporta elementos para una historia social de la epidemia y el mejoramiento de políticas públicas de prevención en torno al VIH/SIDA.OBJECTIVE: To determine the changes in the biography of men with homoerotic practices in the times of AIDS. MATERIAL AND METHODS: A retrospective (biographical survey was administered during the first semester of 2006 to 250 gay/homosexual men in Mexico City. Based on this survey, 633 couple stories, taking place in different time periods, were reconstructed. In addition, taking into account the epidemiologic behavior of HIV-AIDS in Mexico, three couple cohorts were defined as: "before AIDS" 1970-1984; period of "exponential growth" 1985-1995; and "stabilization period" 1996-2005. The 633 stories are distributed along these time-frames, taking the starting date of each relationship as the criterion. RESULTS: During the period of this study, less sexual exclusivity and shorter duration of sexual relationships were found among couple cohorts. The latter process has been

  9. Análise do comportamento e sociedade: implicações para uma ciência dos valores Análisis del comportamiento y sociedad: implicaciones para una ciencia de los valores Behavior analysis and society: implications for a science of values

    Directory of Open Access Journals (Sweden)

    Anne Carolynne Bogo

    2012-01-01

    Full Text Available O behaviorismo radical tem sido alvo de muitas críticas, principalmente no que se refere às questões éticas. A despeito dessas críticas, Skinner considera a análise do comportamento uma ciência dos valores, discutindo a moralidade em termos de comportamento moral. Entretanto, a afirmação de que a análise do comportamento é uma ciência dos valores pode ter consequências sociais distintas a depender do modelo de ciência adotado como pressuposto. O debate científico contemporâneo trata da crise do modelo moderno de ciência e do surgimento de outro: o modelo pós-moderno. Uma das diferenças entre essas duas propostas científicas refere-se à relação entre ciência e sociedade. Considerando esses aspectos, o objetivo deste trabalho é discutir qual modelo de ciência, moderno ou pós-moderno, norteia a assertiva skinneriana que declara a análise do comportamento uma ciência dos valores. Para tanto, serão apresentadas, inicialmente, algumas concepções tradicionais de explicação do comportamento moral e as principais críticas que Skinner dirige a elas. Em seguida, o sistema ético skinneriano será analisado, juntamente às questões sociais envolvidas na prática do analista do comportamento. E, por fim, discutir-se-á como cada modelo de ciência pode subsidiar práticas de intervenção diferentes, com consequências sociais igualmente distintas.El behaviorismo radical ha sido objetivo de muchas críticas, principalmente en lo que se refiere a las cuestiones éticas. Al respeto de esas críticas, Skinner considera el análisis del comportamiento una ciencia de los valores, discutiendo la moralidad en términos de comportamiento moral. No obstante, la afirmación de que el análisis del comportamiento es una ciencia de los valores puede tener consecuencias sociales distintas dependiendo del modelo de ciencia adoptado como supuesto. El debate científico contemporáneo trata la crisis del modelo moderno de ciencia y del

  10. Discharge and infection in retinoblastoma post-enucleation sockets.

    Science.gov (United States)

    Mourits, Daphne L; Hartong, Dyonne T; Budding, Andries E; Bosscha, Machteld I; Tan, H Stevie; Moll, Annette C

    2017-01-01

    To investigate the causes and treatment options for socket discharge and infection in patients enucleated for retinoblastoma (Rb). A questionnaire was filled out by (parents of) ocular prosthesis-wearing patients with a history of enucleation as treatment for Rb. We collected data on patients' characteristics, cleaning habits of the prosthesis, frequency of socket irritation, discharge, and infection, and use of antibiotics. With ordinal logistic regression analysis, factors related to the outcome parameters (frequency of irritation, mucoid and purulent discharge) were identified. In a subset of young asymptomatic and symptomatic patients, a swab culture of the socket was performed to determine the presence of microorganisms. A total of 186 patients or their parents (mean age of the patients: 17.3 years, ranging from 0.8 to 88.3 years) filled out the questionnaire. Irritation, mucoid discharge, and purulent discharge were frequently (once a month or more often) experienced in 75 (39.5%), 127 (66.8%), and 15 (13.2%) sockets, respectively. Younger age was associated with a higher frequency of mucoid and purulent discharge. Radiation therapy, chemotherapy, gender, age at surgery, cleaning frequency, and nocturnal wear were not associated with the outcome parameters. In a subgroup of 26 patients, the sockets were swabbed and cultured. All symptomatic patients had a positive bacterial culture versus 15% (2/13) of the asymptomatic patients ( P socket infection. These complaints were found to decrease with increasing age, but did not seem to be influenced by cleaning or wearing habits. Symptomatic sockets, with and without discharge, were correlated with the presence of pathogenic bacteria for which local antibiotic treatment seemed effective in most cases.

  11. Cell size checkpoint control by the retinoblastoma tumor suppressor pathway.

    Science.gov (United States)

    Fang, Su-Chiung; de los Reyes, Chris; Umen, James G

    2006-10-13

    Size control is essential for all proliferating cells, and is thought to be regulated by checkpoints that couple cell size to cell cycle progression. The aberrant cell-size phenotypes caused by mutations in the retinoblastoma (RB) tumor suppressor pathway are consistent with a role in size checkpoint control, but indirect effects on size caused by altered cell cycle kinetics are difficult to rule out. The multiple fission cell cycle of the unicellular alga Chlamydomonas reinhardtii uncouples growth from division, allowing direct assessment of the relationship between size phenotypes and checkpoint function. Mutations in the C. reinhardtii RB homolog encoded by MAT3 cause supernumerous cell divisions and small cells, suggesting a role for MAT3 in size control. We identified suppressors of an mat3 null allele that had recessive mutations in DP1 or dominant mutations in E2F1, loci encoding homologs of a heterodimeric transcription factor that is targeted by RB-related proteins. Significantly, we determined that the dp1 and e2f1 phenotypes were caused by defects in size checkpoint control and were not due to a lengthened cell cycle. Despite their cell division defects, mat3, dp1, and e2f1 mutants showed almost no changes in periodic transcription of genes induced during S phase and mitosis, many of which are conserved targets of the RB pathway. Conversely, we found that regulation of cell size was unaffected when S phase and mitotic transcription were inhibited. Our data provide direct evidence that the RB pathway mediates cell size checkpoint control and suggest that such control is not directly coupled to the magnitude of periodic cell cycle transcription.

  12. Quality of life of adult retinoblastoma survivors in the Netherlands

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    Cohen-Kettenis Peggy T

    2007-06-01

    Full Text Available Abstract Background To assess the quality of life (QoL and predictors thereof in Dutch adult hereditary and non-hereditary retinoblastoma (RB survivors. Methods In this population-based cross-sectional study, a generic QoL questionnaire (SF-36 and a disease-specific interview were administered to 87 adult RB survivors aged 18 to 35 years. Their QoL data were compared with those of a Dutch healthy reference group. Among the RB hereditary/non-hereditary survivors, the QoL was compared and predictors for QoL were identified by linear multiple regression analyses. Results As a group, RB survivors scored significantly lower than the reference group on the SF-36 subscale 'mental health' (t = -27, df = 86, p Conclusion In this exploratory study, it appears that the group of adult RB survivors experience a relatively good overall but slightly decreased QoL compared with the reference group. However, they report more problems with regard to their mental health (anxiety, feelings of depression, and loss of control. Hereditary RB survivors differ significantly from non-hereditary RB survivors only in 'general health'. Bullying in childhood and subjective experience of impairment are the main predictors of a worse QoL. In order to prevent worsening of QoL, or perhaps to improve it, clinicians should make an inventory of these issues at an early stage. We recommend further research to assess the specific psychological factors that may lead to mental health problems in this population.

  13. Intra-arterial chemotherapy for retinoblastoma: First Indian report

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    Pukhraj Rishi

    2015-01-01

    Full Text Available Aim: To describe treatment outcomes and complications of selective intra-arterial chemotherapy (IAC for retinoblastoma (RB in Indian eyes. Materials and Methods: Single center, retrospective interventional case series of 6 eyes with RB who underwent IAC using Melphalan (3 mg/5 mg/7.5 mg and topetecan (1 mg (n = 4 or melphalan (3 mg/5 mg/7.5 mg alone (n = 2 between December 2013 and June 2014. In all, 17 IAC procedures were performed using selective ophthalmic artery cannulation. Treatment outcomes were evaluated in terms of tumor control, vitreous and subretinal seeds control and globe salvage rates. Results: IAC was employed as primary (n = 1 or secondary (n = 5 modality of treatment. Each eye received mean 3 IAC sessions (median: 3; range: 1-4 sessions. Eyes were classified according to international classification of RB as Group B (n = 1, C (n = 1, D (n = 2 and E (n = 2. Following IAC, complete regression of the main tumor was seen in 3 cases (50%, partial regression in 2 (33%, while 1 case (15% showed no response. Of 4 eyes with subretinal seeds, 1 (25% eye had complete regression while 3 (75% eyes had partial regression. Of 5 eyes with vitreous seeds, 2 (40% eyes had complete regression while 3 (60% eyes had a partial response. Globe salvage was achieved in 5 of 6 eyes (83%. Diffuse choroidal atrophy and vitreous hemorrhage were observed in 1 (17% eye, each. No hematologic toxicity or cerebro-vascular events were observed. Mean follow-up period was 5.5 months (median: 6 months, range: 1-6 months. Conclusion: IAC is an effective therapy for globe preservation in eyes with RB. Larger studies with longer follow-up are required to validate these results.

  14. Risco de vida e natureza do SAMU: demanda não pertinente e implicações para a enfermagem Riesgo de vida y naturaleza del SAMU: perspectivas de los usuarios e implicaciones para la enfermería Life risk and nature of SAMU: users' perspectives and implications for nursing

    Directory of Open Access Journals (Sweden)

    Andréa Márian Veronese

    2012-12-01

    Full Text Available O artigo faz um recorte na análise realizada em um estudo qualitativo, desenvolvido em 2009, cujo objetivo foi investigar a demanda de pedidos de socorro ao Serviço de Atendimento Móvel de Urgência/Porto Alegre (SAMU, por ele classificada como não pertinente. As informações foram obtidas em 16 entrevistas semiestruturadas, realizadas com os solicitantes desta demanda, utilizando-se, como orientação metodológica, a Teoria Fundamentada nos Dados. O artigo aborda o conteúdo da subcategoria "Entrando em conflito com a regulação do SAMU na avaliação do risco de vida", enfocando as divergências entre a regulação e a percepção dos usuários sobre o funcionamento do serviço e significado de "risco de vida", fatores implicados na construção da demanda não pertinente. A importância da Enfermagem, neste cenário, está na sua competência para realizar ações de educação em primeiros socorros e para participar de projetos intersetoriais capazes de intervir em situações geradoras de vulnerabilidade.El artículo hace un corte del análisis en un estudio cualitativo desarrollado en 2009 cuyo objetivo fue investigar la demanda de pedidos de socorro al Servicio de Atendimiento Móvil de Urgencia/Porto Alegre (SAMU que la clasificó como no pertinente. Las informaciones resultaron de 16 entrevistas semiestructuradas con los sujetos de esta demanda, utilizándose como orientación metodológica la Teoría Fundamentada. El artículo aborda el contenido de la subcategoría "Entrando en conflicto con la regulación del SAMU en la evaluación del riesgo de vida", enfocando las divergencias entre la regulación y la percepción de los usuarios acerca del funcionamiento del servicio y significado de "riesgo de vida", factores implicados en la construcción de la demanda no pertinente. La Enfermería se destaca en este escenario por su competencia en realizar acciones de educación sobre primeros socorros y participar de proyectos

  15. Implicaciones educativas de los símbolos deportivos

    OpenAIRE

    Osúa Quintana, Jordi

    2010-01-01

    El món de l’esport va més enllà de la seva pràctica. Al voltant dels esdeveniments esportius existeix un univers simbòlic carregat de significat. Els clubs, els escuts, la indumentària dels equips, els estadis i els objectes de record generen emocions entre els aficionats i fan possible la seva adscripció als valors del grup social representat per l’equip. Davant d’aquest fet els educadors es troben davant d’un doble repte. Primer, poden aprofitar la significació dels símbols esportius per mi...

  16. A pp32-retinoblastoma protein complex modulates androgen receptor-mediated transcription and associates with components of the splicing machinery

    International Nuclear Information System (INIS)

    Adegbola, Onikepe; Pasternack, Gary R.

    2005-01-01

    We have previously shown pp32 and the retinoblastoma protein interact. pp32 and the retinoblastoma protein are nuclear receptor transcriptional coregulators: the retinoblastoma protein is a coactivator for androgen receptor, the major regulator of prostate cancer growth, while pp32, which is highly expressed in prostate cancer, is a corepressor of the estrogen receptor. We now show pp32 increases androgen receptor-mediated transcription and the retinoblastoma protein modulates this activity. Using affinity purification and mass spectrometry, we identify members of the pp32-retinoblastoma protein complex as PSF and nonO/p54nrb, proteins implicated in coordinate regulation of nuclear receptor-mediated transcription and splicing. We show that the pp32-retinoblastoma protein complex is modulated during TPA-induced K562 differentiation. Present evidence suggests that nuclear receptors assemble multiprotein complexes to coordinately regulate transcription and mRNA processing. Our results suggest that pp32 and the retinoblastoma protein may be part of a multiprotein complex that coordinately regulates nuclear receptor-mediated transcription and mRNA processing

  17. Downregulation of HDAC9 inhibits cell proliferation and tumor formation by inducing cell cycle arrest in retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yiting; Wu, Dan; Xia, Fengjie; Xian, Hongyu; Zhu, Xinyue [Medical School of Nanjing University, Department of Ophthalmology, Jinling Hospital, Nanjing, 210002 (China); Cui, Hongjuan, E-mail: hcui@swu.edu.cn [State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Chongqing, 400716 (China); Huang, Zhenping, E-mail: huangzhenping19633@163.com [Medical School of Nanjing University, Department of Ophthalmology, Jinling Hospital, Nanjing, 210002 (China)

    2016-04-29

    Histone deacetylase 9 (HDAC9) is a member of class II HDACs, which regulates a wide variety of normal and abnormal physiological functions. Recently, HDAC9 has been found to be overexpressed in some types of human cancers. However, the role of HDAC9 in retinoblastoma remains unclear. In this study, we found that HDAC9 was commonly expressed in retinoblastoma tissues and HDAC9 was overexpressed in prognostically poor retinoblastoma patients. Through knocking down HDAC9 in Y79 and WERI-Rb-1 cells, the expression level of HDAC9 was found to be positively related to cell proliferation in vitro. Further investigation indicated that knockdown HDAC9 could significantly induce cell cycle arrest at G1 phase in retinoblastoma cells. Western blot assay showed downregulation of HDAC9 could significantly decrease cyclin E2 and CDK2 expression. Lastly, xenograft study in nude mice showed that downregulation of HDAC9 inhibited tumor growth and development in vivo. Therefore, our results suggest that HDAC9 could serve as a novel potential therapeutic target in the treatment of retinoblastoma. - Highlights: • High expression of HDAC9 correlates with poor patient prognosis. • Downregulation of HDAC9 inhibits cell proliferation in retinoblastoma cells. • Downregulation of HDAC9 induces cell cycle arrest at G1 phase in retinoblastoma cells. • Downregulation of HDAC9 suppresses tumor growth in nude mice.

  18. El concepto de «racismo» en Michel Foucault y Frantz Fanon: ¿teorizar desde la zona del ser o desde la zona del no-ser?

    Directory of Open Access Journals (Sweden)

    Ramón Grosfoguel

    2012-01-01

    Full Text Available Este artículo trata acerca de la emergencia histórica del racismo en el sistema-mundo y la definición del concepto de racismo. El mismo discute como contrapunteo la visión del racismo en Michel Foucault y la de Frantz Fanon. Este escrito provee una discusión acerca de las implicaciones epistémicas descoloniales de la teoría de Fanon acerca del racismo.

  19. Crisis en Costa de Marfil: antecedentes internos e implicaciones internacionales

    Directory of Open Access Journals (Sweden)

    Florent Frasson-Quenoz

    2011-11-01

    Full Text Available Tras la crisis electoral del 2010-2011, este artículo presenta de manera sintética una genealogía política de esta situación y las consecuencias que va a tener ese fin del conflicto armado tanto para el Estado marfileño como para la sociedad internacional.

  20. Skin fibroblasts from a D-deletion type retinoblastoma patient are abnormally X-ray sensitive

    International Nuclear Information System (INIS)

    Weichselbaum, R.R.; Nove, J.; Little, J.B.

    1977-01-01

    Retinoblastoma is a rare malignant eye tumour that appears either spontaneously or in genetically predisposed persons. The latter group is composed of persons who inherit the tumour with a dominant mode of transmission (the familial type) and those who have a deletion in the long arm of chromosome 13 referred to as the D-deletion type. When this deletion is present it is observed in many somatic cells and is often associated with structural defects. Survivors of the genetic forms of retinoblastoma have an increased risk of the development of cancers at other sites. A single genetic locus is unlikely to predispose many somatic cells to tumour formation unless a fundamental molecular defect, possibly related to DNA repair, is present. In order to investigate this hypothesis a study was made of the in vitro X-ray sensitivity of skin fibroblasts derived from three retinoblastoma patients, comprising a pair of twins with the familial type accompanied by no gross chromosome abnormalities, and a patient with the D-deletion type. It was found that fibroblasts derived from the D-deletion patient were significantly more radiosensitive than those from the other two patients. X-ray survival curves are shown. It is concluded that skin fibroblasts derived from a patient with the D-deletion variant of retinoblastoma are abnormally radiosensitive. Future investigations may indicate a specific defect in molecular repair of DNA that will explain the predisposition of these patients to the development of other tumours. (U.K.)

  1. A longitudinal investigation of parenting stress in caregivers of children with retinoblastoma.

    Science.gov (United States)

    Willard, Victoria W; Qaddoumi, Ibrahim; Zhang, Hui; Huang, Lu; Russell, Kathryn M; Brennan, Rachel; Wilson, Matthew W; Rodriguez-Galindo, Carlos; Phipps, Sean

    2017-04-01

    Retinoblastoma is typically diagnosed in young children and may present unique parenting challenges. Qualitative research suggests that parents experience distress related to the initial diagnosis and treatment that subsequently resolves. The objectives were to systematically assess parenting stress over time in parents of young children with retinoblastoma and to examine associations between parenting stress and child outcomes. Parents of children with retinoblastoma completed the Parenting Stress Index (PSI) during serial psychological assessments scheduled based on the child's age (6 months to 5 years). Caregivers of 92 patients (85.9% mothers) completed the assessments. Child outcomes included developmental functioning and parent-reported adaptive functioning. At baseline and age 5, all subscales on the PSI were within normal limits, and most were significantly below normative means (i.e., demonstrating low levels of stress). All domains remained relatively stable over time. Associations between parenting stress and child outcomes were much stronger at age 5 than at baseline. Child-directed parenting stress was a small but significant contributor to declines in child functioning over time. Parents of children with retinoblastoma report normal levels of parenting stress while their children are young. However, baseline parenting stress appears to contribute to changes in child functioning over time. Future studies should assess illness-related aspects of adjustment to further understand the parenting experience of young children with cancer and/or having a visually impaired child. © 2016 Wiley Periodicals, Inc.

  2. The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation

    DEFF Research Database (Denmark)

    Fajas, Lluis; Egler, Viviane; Reiter, Raphael

    2002-01-01

    The retinoblastoma protein (RB) has previously been shown to facilitate adipocyte differentiation by inducing cell cycle arrest and enhancing the transactivation by the adipogenic CCAAT/enhancer binding proteins (C/EBP). We show here that the peroxisome proliferator-activated receptor gamma...

  3. Characterization of the retinoblastoma binding proteins RBP1 and RBP2

    DEFF Research Database (Denmark)

    Fattaey, A R; Helin, K; Dembski, M S

    1993-01-01

    The retinoblastoma gene product, pRB, regulates cell proliferation by binding to and inhibiting the activity of key growth promoting proteins. Several cellular proteins have been shown to bind directly to pRB and the genes encoding a number of them have been isolated. The protein product of one...

  4. Total retinal detachments due to retinoblastoma: Outcomes following intra-arterial chemotherapy/ophthalmic artery chemosurgery.

    Directory of Open Access Journals (Sweden)

    Megan A Rowlands

    Full Text Available To report on the rate and timing of retinal reattachment and outcomes for retinoblastoma children who have total retinal detachments at presentation to our center and were treated with intra-arterial chemotherapy (ophthalmic artery chemosurgery, OAC.Single-center retrospective review of retinoblastoma patients who presented with total retinal detachments and were subsequently treated with OAC at MSKCC between May 2006 and July 2016. Endpoints were retinal detachment resolution, visual function, ERG amplitude, ocular survival, and patient survival from metastases.87 eyes of 84 retinoblastoma patients were included. Using a survival multistate model, by 36 months of follow-up, there was a 54% cumulative probability of complete retinal reattachment and a 76% probability of partial reattachment. 24% of eyes that completely reattached received only OAC without any prior or adjuvant treatments. Eyes that completely reattached were significantly more likely to have been diagnosed at a younger age (p<0.0001 and to have greater initial ERG values (p = 0.006. At final follow-up, 14% of eyes had gained at least 25 μV of ERG activity, and 8.0% had achieved hand motion vision or better, including one to 20/60. 13% of eyes were enucleated. No patient died from metastatic disease, and only one developed metastases.OAC can successfully treat previously considered "non-salvageable" retinoblastoma eyes with total retinal detachments, promote retinal reattachment in the majority of eyes, and preserve ocular and patient survival.

  5. Retinoblastoma - MR appearance using a surface coil in comparison with histopathological results

    Energy Technology Data Exchange (ETDEWEB)

    Lemke, Arne-Joern; Kazi, Iris; Mergner, Ulrike; Senfft von Pilsach, Marie-Isabell; Felix, Roland [Campus Virchow-Klinikum, Charite, Universitaetsmedizin Berlin, Berlin (Germany); Foerster, Paul I. [Universitaetsaugenklinik, Klinikum der Universitaet Muenchen-Innenstadt, Muenchen (Germany); Heimann, Heinrich; Bechrakis, Nikolaos; Foerster, Michael [Campus Benjamin-Franklin, Charite, Universitaetsmedizin Berlin, Berlin (Germany); Schueler, Andreas [Universitaetsaugenklinik Essen, Essen (Germany); Hosten, Norbert [Institut fuer Diagnostische Radiologie und Neuroradiologie, Klinikum der Ernst-Moritz-Arndt-Universitaets Greifswald, Greifswald (Germany)

    2007-01-15

    The purpose of this work was to evaluate the characteristic appearance of untreated retinoblastoma on a large sample in comparison to the histological findings after therapeutical enucleation. In a prospective clinical trial 46 children with retinoblastoma in 63 affected untreated eyes were examined under general anesthesia on MRI using a 1.5-T system. The examinations were performed with a special surface coil applying an examination protocol including fast T2- and T1-weighted spin echo sequences and additional fast T1-WI after intravenous injection of Gd-DTPA in different planes. The imaging results were compared to the histopathological findings in 29 patients with 30 affected eyes. Comparing MRI findings and histopathological results, optic nerve infiltration was detected with a sensitivity of 53.8% and a specificity of 82.3% on MRI, infiltration of the choroid with a sensitivity of 75.0% and a specificity of 100.0%, and the degree of tumor calcification with a sensitivity of 91.7% and a specificity of 88.9%. In this study the characteristic MR appearance of untreated retinoblastoma was evaluated. MRI was helpful in relevant aspects of pretherapeutical retinoblastoma staging, deficits remain regarding optic nerve infiltration. (orig.)

  6. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein

    DEFF Research Database (Denmark)

    Helin, K; Harlow, E; Fattaey, A

    1993-01-01

    Loss of a functional retinoblastoma tumor suppressor gene product, pRB, is a key step in the development of many human tumors. pRB is a negative regulator of cell proliferation and appears to participate in control of entry into the S phase of the cell cycle. The recent demonstration that pRB binds...

  7. Deregulated MAPK activity prevents adipocyte differentiation of fibroblasts lacking the retinoblastoma protein

    DEFF Research Database (Denmark)

    Hansen, Jacob B; Petersen, Rasmus K; Jørgensen, Claus

    2002-01-01

    A functional retinoblastoma protein (pRB) is required for adipose conversion of preadipocyte cell lines and primary mouse embryo fibroblasts (MEFs) in response to treatment with standard adipogenic inducers. Interestingly, lack of functional pRB in MEFs was recently linked to elevated Ras activity...

  8. Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice

    NARCIS (Netherlands)

    Boesten, L.S.M.; Zadelaar, A.S.M.; Nieuwkoop, A. van; Hu, L.; Jonkers, J.; Water, B. van de; Gijbels, M.J.J.; Made, I. van der; Winther, M.P.J. de; Havekes, L.M.; Vlijmen, B.J.M. van

    2006-01-01

    The cellular composition of an atherosclerotic lesion is determined by cell infiltration, proliferation, and apoptosis. The tumor suppressor gene retinoblastoma (Rb) has been shown to regulate both cell proliferation and cell death in many cell types. To study the role of macrophage Rb in the

  9. Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience.

    Science.gov (United States)

    Gobin, Y Pierre; Dunkel, Ira J; Marr, Brian P; Brodie, Scott E; Abramson, David H

    2011-06-01

    To determine whether intra-arterial chemotherapy is safe and effective in advanced intraocular retinoblastoma. Retinoblastoma often presents with advanced intraocular disease and, despite conventional treatment with intravenous chemotherapy and external beam radiation therapy, may still require enucleation. Single-arm, prospective registry from May 30, 2006, to May 30, 2010, at an ophthalmic oncology referral center with ambulatory care. A total of 95 eyes of 78 patients with unilateral or bilateral retinoblastoma were treated. The intervention was selective catheterization of the ophthalmic artery and injection of chemotherapy, usually melphalan with or without topotecan. Drug dosage was determined by age and angioanatomy. The main outcome measures were procedural success, event-free (enucleation or radiotherapy) ocular survival, and ocular and extraocular complications. Catheterization succeeded in 98.5% of procedures. There were 289 chemotherapy injections (median, 3 per eye). The Kaplan-Meier estimates of ocular event-free survival rates at 2 years were 70.0% (95% confidence interval, 57.9%-82.2%) for all eyes, 81.7% (95% confidence interval, 66.8%-96.6%) for eyes that received intra-arterial chemotherapy as primary treatment, and 58.4% (95% confidence interval, 39.5%-77.2%) for eyes that had previous treatment failure with intravenous chemotherapy and/or external beam radiation therapy. There were no permanent extraocular complications. Our experience suggests that intra-arterial chemotherapy is safe and effective in the treatment of advanced intraocular retinoblastoma.

  10. Restrictions in daily life after retinoblastoma from the perspective of the survivors

    NARCIS (Netherlands)

    van Dijk, J.; Oostrom, K.J.; Huisman, J.; Moll, A.C.; Cohen-Kettenis, P.T.; Ringens, P.J.; Imhof, S.M.

    2010-01-01

    Background. Little is known about the impact of retinoblastoma (RB) on the health status of survivors in terms of disabilities and worries, both of which may restrict participation in activities of daily life. Methods. In this population-based cross-sectional study, content analysis was used to

  11. RB1 mutation spectrum in a comprehensive nationwide cohort of retinoblastoma patients

    NARCIS (Netherlands)

    Dommering, Charlotte J.; Mol, Berber M.; Moll, Annette C.; Burton, Margaret; Cloos, Jacqueline; Dorsman, Josephine C.; Meijers-Heijboer, Hanne; van der Hout, Annemarie H.

    Background Retinoblastoma (Rb) is a childhood cancer of the retina, commonly initiated by biallelic inactivation of the RB1 gene. Knowledge of the presence of a heritable RB1 mutation can help in risk management and reproductive decision making. We report here on RB1 mutation scanning in a unique

  12. Radiation-induced fibrosarcoma of the mandible following treatment for bilateral retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Ferlito, A; Recher, G [Padua Univ. (Italy); Tomazzoli, L

    1979-10-01

    A case of fibrosarcoma of the mandible following radiotherapy for bilateral retinoblastoma and occurring in an 11-year-old female child is described. After a clinical description of the case, reported with histological documentation, problems connected with the pathogenesis of the malignancies are dealt with. Besides irradiation, genetic mutation as a carcinogenetic co-factor is taken into consideration. (author).

  13. 3D diagnostic imaging of retinoblastoma with a novel optical coherence tomography clinical system

    NARCIS (Netherlands)

    Nadyarnykh, O.; Moll, Annette C; De Boer, Johannes F.

    Purpose : Reliable in-vivo differentiation between the vital tumor / benign masses, and side effects is the main challenge for retinoblastoma, a retinal malignancy occurring in infancy. We have started an observational clinical study using our novel swept source OCT imaging system operating at

  14. Alteration of plant meristem function by manipulation of the Retinoblastoma-like plant RRB gene

    Science.gov (United States)

    Durfee, Tim [Madison, WI; Feiler, Heidi [Albany, CA; Gruissem, Wilhelm [Forch, CH; Jenkins, Susan [Martinez, CA; Roe, Judith [Manhattan, KS; Zambryski, Patricia [Berkeley, CA

    2007-01-16

    This invention provides methods and compositions for altering the growth, organization, and differentiation of plant tissues. The invention is based on the discovery that, in plants, genetically altering the levels of Retinoblastoma-related gene (RRB) activity produces dramatic effects on the growth, proliferation, organization, and differentiation of plant meristem.

  15. Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes

    NARCIS (Netherlands)

    Beijersbergen, R.L.; Carlée, L.; Kerkhoven, R.M.; Bernards, R.A.

    1995-01-01

    The orderly progression through the cell cycle is mediated by the sequential activation of several cyclin/cyclin-dependent kinase (cdk) complexes. These kinases phosphorylate a number of cellular substrates, among which is the product of the retinoblastoma gene, pRb. Phosphorylation of pRb in late

  16. Irradiation sequels of retinoblastomas. Sequelles de l'irradiation externe des retinoblastomes

    Energy Technology Data Exchange (ETDEWEB)

    Benk, V; Habrand, J L; Bloch Michel, E; Soussaline, M; Sarrazin, D [Centre de Lutte Contre le Cancer Gustave-Roussy, 94 - Villejuif (France)

    1993-01-01

    From 1975 to 1985, 34 children with a non-metastatic retinoblastoma were irradiated at the Institut Gustave-Roussy. After enucleation, 19 bilateral tumors were irradiated by two lateral opposed fields and 15 unilateral tumors by one lateral and anterior field, in the case of optic nerve being histologically positive. Dose was 45 Gy, 1.8 Gy per fraction. The 10-year-survival rate for unilateral and bilateral retinoblastomas was 79%. Long term sequels were available for 25 patients: 88% retained one functional eye. Three children with bilateral retinoblastomas developed a cataract in the residual eye between 2 and 5 years after irradiation, none with unilateral tumor. Nine patients (36%), seven with unilateral and two with bilateral tumor developed a cosmetical problem that required multiple surgical rehabilitation between 3 and 14 years after irradiation. Nine children (36%), five with unilateral and four with bilateral tumors developed growth hormone deficit between 2 and 8 years after irradiation that required hormone replacement. Their pituitary gland received 22 to 40 Gy. No osteosarcoma occurred in this population. Among long-term sequels, following irradiation for retinoblastoma, cosmetical deformities represent disabling sequels that could justify new approaches in radiotherapy, as protontherapy combined with 3-D-treatment planning.

  17. The murine retinoblastoma homolog maps to chromosome 14 near Es-10

    NARCIS (Netherlands)

    Stone, J.C.; Crosby, J.J.; Kozak, C.A.; Schievella, A.R.; Bernards, R.A.; Nadeau, J.H.

    1989-01-01

    Restriction fragment length variants have been exploited to map genetically Rb-1, the murine homolog of the human retinoblastoma gene. Rb-1 localized to mouse chromosome 14 on the basis of results from analysis of somatic cell hybrids. In an interspecific backcross involving Mus spretus, Rb-1 and

  18. RNA-Sequencing of Primary Retinoblastoma Tumors Provides New Insights and Challenges Into Tumor Development

    Directory of Open Access Journals (Sweden)

    Sailaja V. Elchuri

    2018-05-01

    Full Text Available Retinoblastoma is rare tumor of the retina caused by the homozygous loss of the Retinoblastoma 1 tumor suppressor gene (RB1. Loss of the RB1 protein, pRB, results in de-regulated activity of the E2F transcription factors, chromatin changes and developmental defects leading to tumor development. Extensive microarray profiles of these tumors have enabled the identification of genes sensitive to pRB disruption, however, this technology has a number of limitations in the RNA profiles that they generate. The advent of RNA-sequencing has enabled the global profiling of all of the RNA within the cell including both coding and non-coding features and the detection of aberrant RNA processing events. In this perspective, we focus on discussing how RNA-sequencing of rare Retinoblastoma tumors will build on existing data and open up new area’s to improve our understanding of the biology of these tumors. In particular, we discuss how the RB-research field may be to use this data to determine how RB1 loss results in the expression of; non-coding RNAs, causes aberrant RNA processing events and how a deeper analysis of metabolic RNA changes can be utilized to model tumor specific shifts in metabolism. Each section discusses new opportunities and challenges associated with these types of analyses and aims to provide an honest assessment of how understanding these different processes may contribute to the treatment of Retinoblastoma.

  19. Patrones biogeográficos de los tenebriónidos epigeos (Coleoptera: Tenebrionidae del Área Natural Protegida Península Valdés, Argentina: implicaciones para su conservación Biogeographic patterns of epigean tenebrionids (Coleoptera: Tenebrionidae from Protected Natural Area Península Valdés, Argentina: implications for its conservation

    Directory of Open Access Journals (Sweden)

    Rodolfo Carrara

    2011-12-01

    Full Text Available Se realizó un estudio sobre los patrones biogeográficos de los tenebriónidos epigeos (Coleoptera: Tenebrionidae que habitan el Área Natural Protegida Península Valdés (Chubut, Argentina, basado en datos de colecciones y material recolectado en viajes a la zona. Se presenta una lista exhaustiva de las especies en la que se consigna el grado de adaptación a la aridez de cada una de ellas; un análisis de la calidad del inventario y la estimación de la riqueza total de especies; una evaluación de los patrones de distribución y riqueza, y la identificación de áreas de significativa mayor riqueza o hotspots. Los resultados indicaron que 25 especies con diferente grado de adaptación a la aridez habitan la península, aunque se estima que la riqueza total del área debería ser de 27. Además, se reconoció que los rangos de distribución de los tenebriónidos siguen una distribución log-normal y que sólo 3 especies son endémicas. Espacialmente, la riqueza se distribuyó de forma agregada en la península y se determinaron 10 hotspots. Finalmente, considerando que en la península Valdés están permitidas actividades productivas que originan una importante degradación del hábitat, se examina la implicancia de los resultados para la conservación de los tenebriónidos epigeos.We conducted a study of the biogeographic patterns of epigean tenebrionids (Coleoptera: Tenebrionidae that inhabit the Protected Natural Area Península Valdés (Chubut, Argentina, based on data obtained from collections and collecting trips. We present a comprehensive species list, where we detail the degree of adaptation to aridity shown by each species, an analysis of the quality of the inventory, an estimation of total species richness, and an evaluation of distribution and richness patterns, with the identification of areas of significantly greater richness or "hotspots". The results indicated that 25 species with different degrees of adaptation to aridity

  20. Vulnerabilidade do lugar vs. vulnerabilidade sociodemográfica: implicações metodológicas de uma velha questão Vulnerabilidad del lugar vs. vulnerabilidad sociodemográfica: implicaciones metodológicas de una vieja cuestión Place vulnerability vs. sociodemographic vulnerability: methodological implications of a very old issue

    Directory of Open Access Journals (Sweden)

    Eduardo Marandola Jr.

    2009-12-01

    uma orientação geográfica na construção de um diálogo mais estreito entre Geografia e os estudos populacionais, a partir do campo População e Ambiente.La pregunta "¿vulnerabilidad a qué?" es primaria en los estudios sobre riesgos y peligros. En los estudios poblacionales, esta pregunta se dirige a grupos demográficos que están sujetos a determinados peligros, que pueden estar relacionados a las características de la dinámica demográfica o a su situación socioeconómica, ligadas al ciclo vital, a la estructura familiar o a las características migratorias del grupo. El campo de población y ambiente aumentó la dimensión espacial a la problemática, considerando la posición y la situación (relacionales y relativas componentes de los elementos que generan peligros o que suministran condiciones para enfrentarlos. Se advierten, por un lado, la influencia de un abordaje ecológico, que entiende al medio como un conjunto físico-social que influencia y es influenciado por la población, y por otro, la presencia de postulados materialistas, que concibe la relación sociedad-naturaleza como un devenir histórico-social que está pautado por la producción contradictoria y desigual del espacio y de la sociedad. En ambientes fuertemente modificados por lo hombre, como las grandes ciudades, la matriz causal de riesgos y de elementos que pueden interferir en la vulnerabilidad es considerablemente mayor, tornando difícil aprehender relaciones de causalidad entre determinados peligros y ciertas características del grupo demográfico. En vista de ello, mirar hacia los peligros y hacia la vulnerabilidad del lugar es una estrategia que permite, en micro-escala, captar los elementos que interfieren en la producción, aceptación y mitigación de los riesgos. La dimensión ecológica es re-significada al incorporar la dimensión existencial y fenoménica del lugar, entendiendo los grupos demográficos en su relación de involucramiento y pertenencia a su espacio

  1. Demandas do trabalho e controle: implicações em unidades de terapia intensiva pediátrica e neonatal Demandas y control del trabajo: implicaciones en las unidades de tratamiento intensivo pediatrico y neonatal Demands and control of work: implications in pediatric and neonatal intensive care units

    Directory of Open Access Journals (Sweden)

    Monalisa de Cássia Fogaça

    2010-08-01

    Full Text Available Comparar a demanda e o controle sobre trabalho de médicos e enfermeiros que trabalham em unidades de tratamento intensivo pediátrica e neonatal. Estudo transversal com 37 médicos e 20 enfermeiros. Utilizou-se o Job Content Questionnarie. Médicos da UTI Neonatal diferem em suporte social recebido do supervisor (p=0,01 em relação aos da UTI Pediátrica. Enfermeiros da UTI Neonatal apresentam insegurança no trabalho (p=0,05. Médicos e enfermeiros da UTI Pediátrica diferem em controle sobre o trabalho; demanda psicológica do trabalho; esforço físico e suporte do supervisor (pComparación de la demanda y control sobre el trabajo de los médicos y enfermeras que trabajan en las unidades de tratamiento intensivo pediátrico y neonatal. Estudio transversal con 37 médicos y 20 enfermeras. Se utilizó el Job Content Questionnarie. Los médicos de la UCI Neonatal difieren en el apoyo social recibido desde el supervisor (p= 0,01 en comparacion com la UCI Pediátrica. Enfermeras de la UCI Neonatal actualmente la inseguridad en el empleo (p = 0,05. Los médicos y enfermeras de la UCI Pediátrica difieren em el control sobre el trabajo, las exigencias psicológicas del trabajo, esfuerzo físico y el apoyo del supervisor (pTo compare the demand and control over work of physicians and nurses working in pediatric and neonatal critical care units. Cross-sectional study with 37 doctors and 20 nurses. We used the Job Content Questionnarie. Physicians from the ICU Neonatal differ in social support received from the supervisor (p= 0.01 compared to the ICU Pediatric. ICU nurses of the Neonatal present job insecurity (p= 0.05. Physicians and nurses from the ICU Pediatric differ in control over the work, psychological demands of work, physical effort and support of the supervisor (p <0.05. Physicians and nurses from the ICU Neonatal show statistical differences in control over the work, physical effort and support of the supervisor (p<0.05. The work

  2. Folate Decorated Nanomicelles Loaded with a Potent Curcumin Analogue for Targeting Retinoblastoma

    Directory of Open Access Journals (Sweden)

    Hashem Alsaab

    2017-04-01

    Full Text Available The aim of this study was to develop a novel folate receptor-targeted drug delivery system for retinoblastoma cells using a promising anticancer agent, curcumin-difluorinated (CDF, loaded in polymeric micelles. Folic acid was used as a targeting moiety to enhance the targeting and bioavailability of CDF. For this purpose, amphiphilic poly(styrene-co-maleic acid-conjugated-folic acid (SMA-FA was synthesized and utilized to improve the aqueous solubility of a highly hydrophobic, but very potent anticancer compound, CDF, and its targeted delivery to folate overexpressing cancers. The SMA-FA conjugate was first synthesized and characterized by 1H NMR, FTIR and DSC. Furthermore, the chromatographic condition (HPLC for estimating CDF was determined and validated. The formulation was optimized to achieve maximum entrapment of CDF. The particle size of the micelles was measured and confirmed by dynamic light scattering (DLS and transmission electron microscopy (TEM. Cytotoxicity studies were conducted on (Y-79 and WERI-RB retinoblastoma cells. Results showed that the solubility of CDF could be increased with the newly-synthesized polymer, and the entrapment efficiency was >85%. The drug-loaded nanomicelles exhibited an appropriate size of <200 nm and a narrow size distribution. The formulation did not show any adverse cytotoxicity on a human retinal pigment epithelial cell (ARPE-19, indicating its safety. However, it showed significant cell killing activity in both Y-79 and WERI-RB retinoblastoma cell lines, indicating its potency in killing cancer cells. In conclusion, the folic acid-conjugated SMA loaded with CDF showed promising potential with high safety and pronounced anticancer activity on the tested retinoblastoma cell lines. The newly-formulated targeted nanomicelles thus could be a viable option as an alternative approach to current retinoblastoma therapies.

  3. Characterization, treatment and prognosis of retinoblastoma with central nervous system metastasis.

    Science.gov (United States)

    Hu, Huimin; Zhang, Weiling; Wang, Yizhuo; Huang, Dongsheng; Shi, Jitong; Li, Bin; Zhang, Yi; Zhou, Yan

    2018-04-23

    Retinoblastoma is the most common primary intraocular tumor and more and more attention has been paid to the developing countries. This study was aimed to evaluate the clinical features, treatment, and prognosis of retinoblastoma patients with central nervous system (CNS) metastasis in Beijing Tongren Hospital, one of the largest tertiary eye centers in China. Clinical data of 31 consecutive retinoblastoma patients with CNS metastases, who were diagnosed at the Department of Pediatrics in Beijing Tongren Hospital between September 2005 and December 2015, were retrospective analyzed. The median age at presentation was 29 months (range from 5 to 108 months). Magnetic resonance imaging (MRI) results indicated that 16 patients (56.6%, 16/31) presented with meningeal involvement, 12 (38.7%, 12/31) presented with intracranial mass, 11 (35.5%, 11/31) presented with thickened optic nerve, and 5 (16.1%, 5/31) presented with concurrent meningeal and spinal cord membrane involvement. Retinoblastoma cells were detected in the cerebrospinal fluid (CSF) of 12 patients (44.4%, 12/27). Laboratory examinations on the blood and CSF were performed for 11 patients who had received six cycles of systemic chemotherapy, indicated that the serum level of neurone-specific enolase (NSE) after chemotherapy was significantly lower than that before chemotherapy (P < 0.05). At the end of the follow-up, 25 patients were dead with a median survival time of 6 months (1 d - 21 months), and 6 cases were alive and continued to receive treatment. Our results were basically consistent with previous reports in the developing countries, and it could be guidance for clinical treatment, prognosis and prevention of CNS metastases in retinoblastoma.

  4. A 10-year experience of outcome in chemotherapy-treated hereditary retinoblastoma.

    Science.gov (United States)

    Bartuma, Katarina; Pal, Niklas; Kosek, Sonja; Holm, Stefan; All-Ericsson, Charlotta

    2014-08-01

    The aim is to report the 10-year retrospective experience of systemic chemotherapy for a population-based group of patients with hereditary retinoblastoma at a national referral centre. The outcomes include control rates, treatment side-effects, adjuvant therapy, failure rate, survival, secondary cancers and visual acuity. All patients (n = 24, 46 eyes) diagnosed with retinoblastoma and treated with systemic chemotherapy at a national referral centre during 2001-2011 were included. Data were extracted from medical records. The patients were followed for a mean of 60 months (range 13-144). Four-six cycles of VEC was administered to all newly diagnosed group B/C/D/E eyes with bilateral disease and 83% (38 of 46) responded to the treatment. None of the patients discontinued chemotherapy because of adverse reactions. Altogether 26% (12 of 46) of the eyes received second-line therapy (other than thermotherapy, cryotherapy and chemotherapy). The failure rate was 35% (16 of 46) and mortality rate 0%. None of the patients developed CNS manifestations (metastases or trilateral retinoblastoma). One of the patients developed a second primary tumour (osteosarcoma) 4 years following retinoblastoma diagnosis. Altogether 17% (4 of 24) patients received radiation therapy, 28% (13 of 46) of the eyes had to be enucleated, and one patient underwent bilateral enucleation. The age-correlated visual acuity was mean of 73% of expected visual acuity. Group A/B retinoblastomas have a distinct chemotherapy response, while group C/D/E tumours do not respond as well. The success rate was 65%; while patients have a good prognosis for life, approximately one-third of all hereditary cases received radiation therapy or underwent enucleation. © 2013 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

  5. Entrenamiento funcional del core: eje del entrenamiento inteligente

    Directory of Open Access Journals (Sweden)

    Iván Dario Pinzón Ríos

    2015-06-01

    Full Text Available Antecedentes: La evolución del entrenamiento físico busca la optimización de la salud y el bienestar, como piedra angular de todo programa de ejercicio. El Entrenamiento Funcional (EF es recomendable para optimizar el control postural del core, mejorando el balance y la ejecución de actividades de la vida diaria.  Objetivo: Revisar la definición, elementos constitutivos, características e implicaciones del EF del core en el movimiento corporal humano (MCH y la salud desde la perspectiva del fisioterapeuta. Metodología: Se incluyeron artículos en inglés y español de las bases Pubmed, Scielo y Ebsco; adicionalmente se incluyeron fuentes electrónicas e impresas y libros. Resultados: 56 documentos cumplieron los criterios de inclusión. La definición más adoptada de EF fue entrenar con un propósito buscando obtener un efecto positivo en la aptitud física. Las implicaciones del EF en el MCH, se relacionan con la ganancia y mejoría de la estabilidad. La propuesta de EF enfocada a las actividades de la vida diaria incluye fases que permiten adquirir la estabilidad hasta lograr el desarrollo de movimiento que demanden más agilidad. En la planificación del EF se deben estructurar los procesos a ejecutar considerando el criterio de funcionalidad. Para organizar la sesión del EF, el fisioterapeuta cuenta con tres maneras de planificar la sesión: globales, por hemisferios y por grupos musculares. Conclusión: La fundamentación teórica sobre el EF permite al fisioterapeuta comprender y determinar cómo esta modalidad de intervención repercute de manera positiva sobre el desempeño funcional y calidad de vida de los sujetos.

  6. Mudanças tecnológicas e suas implicações na política de formação do professor Cambios tecnológicos y sus implicaciones en la política de formación del profesor Technological changes and it implications on the teachers formation policy

    Directory of Open Access Journals (Sweden)

    Alda Maria Duarte Araújo Castro

    2005-12-01

    Full Text Available O artigo discute as transformações ocorridas no mundo do trabalho, provocadas pela globalização da economia, pelas inovações tecnológicas e pela reestruturação produtiva, procurando evidenciar o impacto dessas transformações no perfil dos trabalhadores e, conseqüentemente, nos processos formativos. Em especial, o artigo enfoca a influência dessa nova lógica do mercado na política de formação de professores da educação básica. Para tanto, tomou-se, como referência, os documentos oficiais, entre eles, Referenciais para Formação de Professores, elaborado pelo Ministério da Educação e Cultura e o Parecer nº 09/2001, do Conselho Nacional de Educação, que trata das Diretrizes Curriculares Nacionais para a Formação de Professores da Educação Básica, nos quais fica evidente a necessidade de mudar os modelos tradicionais de formação para se ajustar às novas demandas do mercado, utilizando, para isso, modelos formativos mais modernos e flexíveis. Na análise dos documentos, privilegiam-se dois eixos considerados fundamentais para a formação do professor nesse novo cenário: a formação reflexiva e a formação por competência, os mesmos estão articulados com as exigências empresariais e dos organismos internacionais, que acreditam em uma formação mais prática e instrumental capaz de promover a melhoria da qualidade da educação básica.El artículo trata de los cambios ocurridos em el mundo laboral, provocados por la globalización de la economía, por las innovaciones tecnológicas y por la reestructuración productiva, buscando evidenciar el impacto de esas transformaciones en el perfil de los trabajadores y, consecuentemente, los procesos formativos. En especial, el artículo enfoca la influencia de esa nueva lógica del mercado en la política de formación de profesores de educación básica. Para eso, se tomó, como referencia, los documentos oficiales, entre ellos, Referencias para la Formación de

  7. Duración y valoración en la expresión del pasado: implicaciones para la clase de español como segunda lengua (Duration and Judgments in Discussing the Past: Implications for the Spanish as a Second Language Classroom

    Directory of Open Access Journals (Sweden)

    Asunción Martínez-Arbelaiz

    2016-09-01

    Full Text Available En este estudio se analiza el uso del imperfecto en las narraciones de un grupo de estudiantes universitarios, antes y después de un curso de español en situación de inmersión. Aunque la cantidad de errores de imperfecto disminuye en las categorías observadas, se muestra que, a pesar de la instrucción recibida y de la exposición natural al input, persisten ciertos tipos de error en las narraciones, en particular los errores de uso de imperfecto relacionados con los conceptos de duración y valoración. In this study the use of the imperfect tense is analyzed in the compositions of a group of college students, before and after a Spanish course received in an immersion setting. Although the number of errors of the imperfect diminishes in the categories observed, it was shown that, despite the instruction received and the natural exposure to input, several types of errors are still present in the narratives. Errors in the use of imperfect related to the concepts of duration and judgment are particularly persistent.

  8. Discharge and infection in retinoblastoma post-enucleation sockets

    Directory of Open Access Journals (Sweden)

    Mourits DL

    2017-03-01

    Full Text Available Daphne L Mourits,1 Dyonne T Hartong,1 Andries E Budding,2 Machteld I Bosscha,1 H Stevie Tan,1 Annette C Moll1 1Department of Ophthalmology, VU University Medical Center, 2Department of Microbiology, Academic Medical Center, Amsterdam, the Netherlands Purpose: To investigate the causes and treatment options for socket discharge and infection in patients enucleated for retinoblastoma (Rb. Methods: A questionnaire was filled out by (parents of ocular prosthesis-wearing patients with a history of enucleation as treatment for Rb. We collected data on patients’ characteristics, cleaning habits of the prosthesis, frequency of socket irritation, discharge, and infection, and use of antibiotics. With ordinal logistic regression analysis, factors related to the outcome parameters (frequency of irritation, mucoid and purulent discharge were identified. In a subset of young asymptomatic and symptomatic patients, a swab culture of the socket was performed to determine the presence of microorganisms. Results: A total of 186 patients or their parents (mean age of the patients: 17.3 years, ranging from 0.8 to 88.3 years filled out the questionnaire. Irritation, mucoid discharge, and purulent discharge were frequently (once a month or more often experienced in 75 (39.5%, 127 (66.8%, and 15 (13.2% sockets, respectively. Younger age was associated with a higher frequency of mucoid and purulent discharge. Radiation therapy, chemotherapy, gender, age at surgery, cleaning frequency, and nocturnal wear were not associated with the outcome parameters. In a subgroup of 26 patients, the sockets were swabbed and cultured. All symptomatic patients had a positive bacterial culture versus 15% (2/13 of the asymptomatic patients (P<0.001. Common cold was correlated with both symptoms and presence of bacteria. Haemophilus influenzae and Staphylococcus aureus were the species most frequently cultured. Conclusion: Ocular prosthesis-wearing patients often experienced mucoid

  9. La Técnica del Incidente Crítico y sus implicaciones en el desarrollo de la investigación en enfermería The critical incident technique and its implications in the development of the nursing research

    Directory of Open Access Journals (Sweden)

    Ana Lucía Noreña Peña

    2008-03-01

    Full Text Available En este artículo pretende describir, a manera introductoria, la aplicabilidad que tiene la técnica del incidente crítico, como herramienta de investigación cualitativa. A su vez explora el valor que desde sus inicios diversas disciplinas le han atribuido a la técnica para recolectar y analizar datos cualitativos. Su reconocimiento actual está basado en que la técnica permite comprender algunos componentes que pueden estar siendo valorados como "críticos" dentro de una actividad determinada. Se ha considerado que la técnica posee a nivel metodológico propiedades tales como practicidad, flexibilidad, versatilidad y efectividad en su aplicación. En esta breve disertación sobre la técnica, se describen las características generales de la técnica, sus atributos, aplicaciones y los aportes potenciales y reales que su utilización tiene en la investigación científica y el conocimento disciplinar de enfermería.This article describes, in an introductory way, the applicability that the critical incident technique has, as a qualitative research tool. It also explores the value that has been attributed to the technique by diverse disciplines to recollect and analyze qualitative data. Its current acknowledgment is based on the fact that the technique allows to understand some components that can been valued as "critical" among a given activity. It’s been considered that the technique has in the methodological level properties such as practicability, flexibility, versatility, and effectiveness in its application. In this brief dissertation about the technique, it’s described the general characteristics of the technique, its attributes, applications, and the potential and real contributions that its use has in the scientific research and the disciplinary knowledge of nursery.

  10. Psychological and psychopathological reactions in Honduras following Hurricane Mitch: implications for service planning Reacciones psicológicas y psicopatológicas en Honduras después del huracán Mitch: implicaciones para la planificación de los servicios

    Directory of Open Access Journals (Sweden)

    Robert Kohn

    2005-11-01

    los trastornos por estrés postraumático (TSP y otras afecciones piscopatológicas mediante muestras basadas en la comunidad. El presente estudio explora varias reacciones psicopatológicas y sus respectivos factores de riesgo dos meses después de que el huracán Mitch azotó Honduras en octubre de 1998. MÉTODOS: En Tegucigalpa, capital de Honduras, se seleccionó a 800 personas de 15 años de edad o más que vivían en áreas residenciales consideradas de estatus socioeconómico alto, medio o bajo y que habían sufrido los devastadores efectos del huracán en mayor o en menor medida. Para diagnosticar los casos de TSP se utilizó la Entrevista Diagnóstica Internacional Compuesta. La depresión, el abuso de alcohol y la reacción de dolor se evaluaron mediante encuestas de tamizaje, mientras que para la desmoralización se empleó el Cuestionario de Síntomas. Se aplicó la Escala de Impacto de Eventos para establecer la gravedad de la reacción postraumática. RESULTADOS: Se encontró TSP en 10,6% de la muestra. Los encuestados de las áreas residenciales más afectadas estaban más angustiados, tuvieron una mayor puntuación en la evaluación de sufrimiento, y presentaron síntomas de TSP de mayor gravedad. También presentaron mayores tasas de prevalencia de depresión mayor, alcoholismo y problemas emocionales previos. El mejor modelo explicativo del riesgo de sufrir TSP tomó en cuenta el grado de exposición según los eventos traumáticos informados y el incremento de la desmoralización asociada con ellos. Entre las personas con TSP, los factores pronóstico de la gravedad de los trastornos fueron el pertenecer al sexo femenino y el grado de exposición a los eventos traumáticos relacionados con el huracán. CONCLUSIONES: Se calcula que del total de 3,3 millones de adultos (de 15 años de edad o más habitantes de Honduras, más de 492 000 han sufrido TSP debido al huracán Mitch. Para contar con una adecuada preparación sanitaria y ofrecer una apropiada

  11. Dissecting functions of the retinoblastoma tumor suppressor and the related pocket proteins by integrating genetic, cell biology, and electrophoretic techniques

    DEFF Research Database (Denmark)

    Hansen, Klaus; Lukas, J; Holm, K

    1999-01-01

    The members of the 'pocket protein' family, comprising the retinoblastoma tumor suppressor (pRB) and its relatives, p107 and p130, negatively regulate cell proliferation and modulate fundamental biological processes including embryonic development, differentiation, homeostatic tissue renewal...

  12. Control of cell proliferation, endoreduplication, cell size, and cell death by the retinoblastoma-related pathway in maize endosperm

    KAUST Repository

    Sabelli, Paolo A.; Liu, Yan; Dante, Ricardo Augusto; Lizarraga, Lucina E.; Nguyen, Hong N.; Brown, Sara W.; Klingler, John; Yu, Jingjuan; LaBrant, Evan; Layton, Tracy M.; Feldman, Max; Larkins, Brian A.

    2013-01-01

    , and programmed cell death. Although manipulation of these processes could maximize grain yield, how they are regulated and integrated is poorly understood. We show that the Retinoblastoma-related (RBR) pathway controls key aspects of endosperm development

  13. ORIENTACIÓN DE META DE LOS ENTRENADORES Y METODOLOGÍA DE ENTRENAMIENTO: IMPLICACIONES MOTIVACIONALES

    Directory of Open Access Journals (Sweden)

    J.F. Guzmán

    2010-09-01

    Full Text Available

     

    RESUMEN

    En el presente estudio administramos a 34 entrenadores de balonmano un cuestionario de medida de los criterios de éxito deportivo (POSQ y otro de la importancia otorgada a diferentes variables de la metodología de entrenamiento con el fin de analizar el papel predictor de la orientación de meta de los entrenadores sobre la valoración de aspectos determinantes del entrenamiento. Los resultados de los Análisis de Regresión indicaron que la orientación a la tarea se correspondía con la concesión de importancia a: La especificidad del entrenamiento; la agrupación de los jugadores según su nivel de destreza; el control y anotación de los progresos de los jugadores; la libertad del jugador para ejecutar y decidir; y la consideración de la competición como un medio y no como un fin. La orientación al ego predijo positivamente la concesión de importancia a la variedad de ejercicios y la comunicación con los padres para resolver problemas y negativamente la concesión de importancia a la libertad del jugador para ejecutar y decidir. Las implicaciones motivacionales de estos resultados se analizan a la luz de la teoría de la motivación de logro (Nicholls, 1984a,b y la teoría de la autodeterminación (Deci y Ryan, 1985, 1991.
    PALABRAS CLAVE: Motivación de logro, autodeterminación, metodología de entrenamiento.

    ABSTRACT

    In this study 34 handball coaches were administered a questionnaire to measure their criteria of sport success (POSQ and another to measure the importance each placed on different variables of training methodology. The purpose was to analyse the predictor role of coaches' motivational orientation on given importance to determinants of training. Regression analysis results showed

  14. Roturas tendinosas y musculares en el hombro del deportista

    OpenAIRE

    Sanchis, V.; Gastaldi Orquín, Enrique; Ferrando, F.; Diago, T.; Deltoro López, A.

    1991-01-01

    El complejo articular del hombro está sometido a solicitaciones mecánicas en la mayoría de las modalidades deportivas; así el 10-15% de los traumatismos sufridos por los atletas afectan a esta articulación (1). La "patología reina" del hombro del deportista es la inestabilidad, por su frecuencia, importantes implicaciones funcionales y tratamiento problemático. Por el contrario, las roturas musculares y tendinosas del hombro son lesiones poco frecuentes en el dep...

  15. Migración irregular de haitianos hacia república dominicana y sus implicaciones socio-económicas en el desarrollo de ambas naciones

    OpenAIRE

    Ovalles Mejía, José Manuel; Uribe Mendoza, Cristhian José

    2017-01-01

    84 páginas : gráficos. Esta investigación analiza la migración irregular de haitianos hacia la República Dominicana y sus implicaciones socio-económicas en el desarrollo de ambas naciones durante el período 2010-2015. Este tema reviste gran importancia en el entendido de que los dos países analizados, con condiciones económicas, políticas, sociales y culturales con marcadas diferencias, hoy día comparten y conviven en una misma isla a causa del fenómeno de la migración. Se hace una des...

  16. Rapid response to a case of mumps: implications for preventing transmission at a medical research facility Respuesta rápida a un caso de paperas: implicaciones para la prevención del contagio en una instalación de investigación biomédica

    Directory of Open Access Journals (Sweden)

    Gabriela Salmón-Mulanovich

    2009-02-01

    Full Text Available OBJECTIVE: To prevent transmission among the staff and potentially among the non-human primate (NHP colony at the U.S. Naval Medical Research Center Detachment in Peru, where an active case of mumps was discovered in a senior laboratory technician in Sep 03, 2007. MATERIAL AND METHODS: Subjects at the research facility were interviewed and potentially susceptible contacts were tested for mumps IgG. RESULTS: In total, 81 out of 106 staff members (76% had close contact with the case. Only 6/81 (7% had MMR, 33 (41% reported having had mumps, and 8 of 45 (18% of the potentially susceptible individuals did not have immunity (IgG > 20.0. All the susceptible, exposed individuals received MMR vaccine. There were no secondary cases and access to the NHP colony was restricted. DISCUSSION: Immediate and thorough investigation and occupational health response were imperative in preventing secondary cases of mumps among humans and NHP.OBJETIVO: Prevenir el contagio de parotiditis al personal y potencialmente a la colonia de primates no humanos (PNH, tras detectarse un caso en el personal técnico de laboratorio en el Centro de Investigación de Enfermedades de la Marina de los EUA (NMRCD. MATERIAL Y MÉTODOS: El personal fue entrevistado y se hizo una prueba de IgG para parotiditis a los contactos potencialmente susceptibles. RESULTADOS: En total, 81 de 106 miembros del personal tuvo contacto cercano con el caso. Sólo 6/81 (7% tenían vacuna y 33 (41% reportaron haber tenido parotiditis, y 8 de 45 (18% de los susceptibles potenciales no tenían inmunidad (IgG > 20.0. Todos los susceptibles expuestos fueron vacunados y no hubo casos secundarios. Se restringió el acceso a la colonia de PNH. CONCLUSIÓN: La investigación inmediata y la respuesta de salud ocupacional fue imperativa para prevenir casos secundarios de parotiditis en el personal y los NHP.

  17. Vertebrados marinos del neógeno del suroeste de la Península Ibérica

    OpenAIRE

    Toscano Grande, Antonio

    2016-01-01

    Esta Tesis Doctoral aborda el estudio de los vertebrados marinos presentes en las formaciones del Mioceno y Plioceno del SO de la Cuenca del Guadalquivir en la provincia de Huelva, sus aspectos evolutivos e implicaciones paleoecológicas. Los resultados obtenidos permiten definir con mayor resolución la evolución de los ecosistemas litorales y marinos del SO de la Península Ibérica durante el Neógeno superior. Durante esta época, las dos principales vías de comunicación entre el océano Atlánti...

  18. Los tipos de contratación laboral y sus implicaciones en el contrato psicológico

    Directory of Open Access Journals (Sweden)

    Juan Javier Vesga Rodríguez

    2011-01-01

    Full Text Available En el presente artículo se presentan algunas reflexiones, con bases teóricas y empíricas, acerca de las implicaciones que están teniendo lugar en la conformación de los contratos psicológicos de los trabajadores que se encuentran vinculados mediante empleo y formas contemporáneas de contratación, como el outsourcing y las cooperativas de trabajo asociado. Estudios recientes muestran cómo estas otras formas de contratación afectan aspectos psicosociales de los trabajadores, impactando de manera negativa la gestión de las organizaciones. El artículo finaliza con una serie de interrogantes acerca de la confluencia entre los efectos negativos en el contrato psicológico de las formas de tercerización de la fuerza de trabajo, y tendencias actuales de gestión como los equipos de alto desempeño y la gestión del conocimiento.

  19. Trayectorias de persistencia y abandono de estudiantes universitarios no convencionales: implicaciones para la orientación

    Directory of Open Access Journals (Sweden)

    Pilar Figuera Gazo

    2015-01-01

    Full Text Available Uno de los objetivos de la política universitaria a nivel nacional e internacional ha sido la diversificación de las vías de entrada a la universidad para favorecer el acceso más generalizado a la educación superior. Sin embargo, el establecimiento de políticas de acceso debe ir acompañado de medidas para garantizar la permanencia en el sistema. La orientación es uno de los instrumentos más significativos. El artículo presenta los resultados de una investigación longitudinal sobre los procesos de transición y persistencia de una cohorte de estudiantes de ADE y Pedagogía de la Universidad de Barcelona que iniciaron los estudios en el año 2010. Los datos confirman que las situaciones de retraso académico, fracaso y abandono son significativamente superiores entre los estudiantes que accedieron a través de las vías no convencionales (específicamente aquellos procedentes de las vías CFGS, mayores de 25 años y 45 años. A partir de los resultados procedentes de las bases de datos institucionales y de los cuestionarios de seguimiento, se discute las implicaciones para el establecimiento de acciones de orientación y tutoría que contribuyan a la verdadera equidad del sistema.

  20. Implicaciones de la teoría motivacional de la Autodeterminación en el ámbito laboral

    Directory of Open Access Journals (Sweden)

    Juan Alberto Vargas Téllez

    2012-01-01

    Full Text Available Dada su importancia y pertinencia para la motivación en el trabajo, se aborda la Teoría de la Autodeterminación (TAD en relación con el ámbito laboral. Se argumenta sobre las implicaciones positivas que puede tener para esclarecer algunas controversias que generaron los con ceptos de motivación extrínseca e intrínseca, así como para abordar ciertos temas fundamentales de la organización contemporánea: los sistemas de incentivos, la cultura organizacional, el aprendizaje organizacional y la gestión del conocimiento; se concluy e que estos procesos organizacionales contribuirán más a la productividad en la medida que sean congruentes con un cultura laboral que favorezca la satisfacción de tres necesidades psicológicas básicas relacionadas con el trabajo: la autonomía, la competen cia y la socialización o relación, conceptos que postula la Teoría de la Autodeterminación.

  1. Cabeza hacia adelante: una mirada desde la biomecánica y sus implicaciones sobre el movimiento corporal humano

    Directory of Open Access Journals (Sweden)

    Iván Darío Pinzón Ríos

    2015-04-01

    Full Text Available Las condiciones ergonómicas de mobiliario y de equipos, como también la postura incorrecta al estar en posición sedente, de pie o cargando algún peso pueden generar dolores o complicaciones osteomusculares. Dentro de estas, la cabeza hacia adelante es una alteración común detectada en la evaluación postural realizada por los fisioterapeutas. Esta suele asociarse a cambios mecánicos del cuello y columna vertebral, los cuales alteran la funcionalidad de los individuos, causándole discapacidad pues compromete el movimiento de hombros, la movilidad de la articulación temporomandibular, la mecánica respiratoria, desarrollando imbalances musculares, mareos, disfunción vestibular, aumenta el riesgo de fracturas y se asocia con procesos dolorosos como la cervicalgia, dorsalgia y lumbalgia. Por tanto el siguiente artículo tiene por objetivo revisar la fisiopatogénia de la cabeza hacia adelante, desde una perspectiva biomecánica, analizando las implicaciones de esta alteración postural sobre el movimiento corporal humano, proporcionando así herramientas de análisis para el abordaje fisioterapéutico.

  2. e implicaciones de política pública

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    Luis Miguel Galindo

    2006-01-01

    Full Text Available El principal objetivo de este estudio es identificar la existencia del fenómeno del tráfico inducido en México. Los resultados obtenidos indican que la ampliación de las vialidades en México origina un aumento de los viajes y de los kilómetros recorridos como consecuencia de una disminución del tiempo de traslado. Esto es, la demanda de viajes puede modelarse como una función de demanda tradicional en donde una disminución de los costos por transporte, que incluyen tanto costos monetarios directos como de tiempo, se traduce en un aumento de la cantidad o longitud de los viajes. Las estimaciones realizadas indican que la elasticidad de las vialidades al consumo de gasolina es de 0.15, confirmando la presencia del tráfico inducido. Asimismo se presentan algunos ejercicios preliminares sobre posibles estimaciones del tráfico inducido para vialidades específicas, aunque debe reconocerse que los valores estimados para el país no necesariamente se aplican al caso de la Ciudad de México. El conjunto de resultados obtenidos indica que la ampliación de la infraestructura vial viene asociada a un aumento menos que proporcional del tráfico, pues se disminuye momentáneamente la razón de uso de las vialidades que, paulatinamente, se va incrementando. De este modo la ampliación vial genera en el corto plazo una mejora en el servicio que tiende a deteriorarse con el tiempo. Esta mejora en el servicio debe sin embargo evaluarse con referencia a los costos que implica en el largo plazo una opción de desarrollo urbano que privilegia el uso del automóvil como medio de transporte en contraposición a otras alternativas.

  3. Sporadic Retinoblastoma and Parental Smoking and Alcohol Consumption before and after Conception: A Report from the Children's Oncology Group.

    Directory of Open Access Journals (Sweden)

    Saeedeh Azary

    Full Text Available Retinoblastoma is the most frequent tumor of the eye in children and very little is known about the etiology of non-familial (sporadic retinoblastoma. In this study we examined whether parental tobacco smoking or alcohol consumption (pre- or post-conception contribute to the two phenotypes (bilateral or unilateral of sporadic retinoblastoma.Two large multicenter case-control studies identified 488 cases through eye referral centers in the United States and Canada or through the Children's Oncology Group. Controls (n = 424 were selected from among friends and relatives of cases and matched by age. Risk factor information was obtained via telephone interview. We employed multivariable logistic regression to estimate the effects of parental tobacco smoking and alcohol consumption on retinoblastoma.Maternal smoking before and during pregnancy contributed to unilateral retinoblastoma risk in the child: year before pregnancy conditional Odds Ratio (OR, 8.9; 95% confidence interval (CI 1.5-51, and unconditional OR, 2.4; 95% CI, 1.3-4.7; month before or during pregnancy, conditional OR, 3.3; 95% CI, 0.5-20.8, and unconditional OR, 2.8; 95% CI, 1.1-7.0. No association was found for maternal or paternal alcohol consumption.The results of this study indicate that maternal active smoking during pregnancy may be a risk factor for sporadic retinoblastoma. Our study supports a role for tobacco exposures in embryonal tumors.

  4. Precipitaciones extremas y sus implicaciones en procesos de remoción en masa en la planificación urbana de Tampico, México

    Directory of Open Access Journals (Sweden)

    Diego Sánchez González

    2011-01-01

    Full Text Available La investigación analiza la peligrosidad y exposición de las precipitaciones extremas y sus implicaciones en la evaluación y zonificación de los procesos de remoción en masa en la ciudad de Tampico, localizada en la cuenca baja del río Pánuco, México. La metodología emplea un Sistema de Información Geográfica para la agregación de los datos hidrometeorológicos y geomorfológicos, posibilitando el análisis de las variaciones espacio-temporales de las precipitaciones extremas, y sus implicaciones en la evaluación y zonificación de los procesos de remoción en masa, necesarios para la planificación urbana de Tampico. Los resultados indican que la distribución de las precipitaciones extremas favorece la alta agresividad climática, determinante de los procesos de erosión del suelo y de los peligros geomorfológicos, como desprendimientos y flujos de detritos, en el área de estudio. Asimismo, en los próximos años se prevé el aumento de los procesos de remoción en masa asociados a factores ambientales, por un incremento de la ocurrencia e intensidad de las precipitaciones extremas, y a factores antrópicos, por el crecimiento de la población y viviendas expuestas a áreas inestables.

  5. Radiation therapy for retinoblastoma: a retrospective review of 120 patients

    International Nuclear Information System (INIS)

    Pradhan, Deepak G.; Sandridge, Amy L.; Mullaney, Paul; Abboud, Emad; Karcioglu, Zeynel A.; Kandil, Alaa; Mustafa, Mahmoud M.; Gray, Alan J.

    1997-01-01

    Purpose: To characterize the patient population and treatment outcomes in patients with Retinoblastoma (RB) referred for External Beam Orbital Radiotherapy (EBORT) to King Faisal Specialist Hospital and Research Centre (KFSH and RC), Riyadh, Saudi Arabia from 1976 to 1993. Methods and Materials: A retrospective study of 120 patients with RB affecting a total of 192 eyes. Patients were divided into three groups. Group A are 60 patients (64 eyes) treated with EBORT to the intact eye to preserve vision. Reese-Ellsworth (RE) Staging was: 1: 12%; 2: 10%; 3: 12%; 4: 23%; and 5: 43%. Twenty-eight patients (47%) also received Vincristine, Adriamycin, and Cyclophosphamide chemotherapy (C/T). Mean follow-up, per patient, was 48.5 months. Standard treatment until 1992 was 45 Gy in 12 fractions of 3.75 Gy, three times weekly over 18 days. Assuming the α/β ratio for early effects and tumor control at 10, Tk = 21 days, T pot = 5 days, then the Biological Equivalent Dose (BED) was 62 Gy 10 for early effects, and 101 Gy 3 for late effects. Group B are 28 patients (28 eyes) treated for curative intent with EBORT to the orbit for locally advanced disease, usually after enucleation (24 eyes). Nineteen patients (83%) also had C/T. Mean follow-up was 22.6 months. Group C are 37 patients with advanced disease treated with radiotherapy for palliation. Seventeen (46%) also received C/T. Mean follow-up was 11.7 months. Results: Group A-following EBORT useful vision was retained in RE Stage 1 to 5: 7 of 7, 6 of 6, 4 of 8, 10 of 15, and 7 of 28 eyes, respectively. There was no significant difference between patients who received adjuvant chemotherapy and those who did not. Complications included cataract (27%), retinopathy (25%), vitreous hemorrhage (19%), and orbital deformities (11%). In Group B the local control rate was 71%. In Group C, 10 (27%) of the 37 patients were alive at last contact, and 27 (73%) were either terminal or dead of disease. None of Group A or B patients had

  6. Implicaciones de la Intoxicación por Mercurio.

    OpenAIRE

    Myriam Gutiérrez de Salazar

    2004-01-01

    Generalidades

    El mercurio puede encontrarse en diversidad de minerales, yacimientos y en una gran variedad de estados físicos y químicos, cada uno de ellos tiene toxicidad diferente y sus aplicaciones en la industria, la agricultura y la medicina requiere de distintas evaluaciones. En Colombia es de gran importancia su estudio por el uso indiscriminado que se hace del mercurio metálico durante los procesos de “amalgamación” del oro durante la actividad minera de e...

  7. Post-radiation retinal infiltrates simulating recurrent retinoblastoma: a clinical and pathologic case report

    International Nuclear Information System (INIS)

    Judisch, G.F.; Folberg, R.

    1987-01-01

    An 8-month-old boy was found to have a sporadic unilateral stage IIa retinoblastoma, extending inferiorly and temporally from the right fovea. Within 5 weeks of diagnosis the tumor was treated with 4500 rads fractionated over 20 treatments. Examination under anesthesia (EUA) 1 month later revealed unequivocal clinical and echographic evidence of tumor regression. EUA 3 months after completion of radiation therapy revealed continued tumor regression with no evidence of new tumor formation. The third EUA, performed 6 months after radiation treatment, showed that multiple discreet gray-white retinal infiltrates had developed, predominantly in the area immediately below the regressed tumor. Because of concern that these lesions represented viable retinoblastoma, the eye was enucleated. Pathologic examination of these lesions revealed them to be collections of foamy cells containing melanin granules suggestive of pigment epithelial origin

  8. A TaqI RFLP identified at the retinoblastoma locus on chromosome 13

    Energy Technology Data Exchange (ETDEWEB)

    Shiang, R; Murray, J C [Univ. of Iowa, Iowa City (USA); Wiggs, J; Dryja, T [Massachusetts Eye and Ear Infirmary, Boston (USA)

    1988-09-26

    Probe D95HS0.5 is a 0.6 kb fragment subcloned into Bluescribe a pUC19 derivative from a bacterio phage library isolated by a cDNA probe of the retinoblastoma gene. The fragment is released with the enzymes HindIII and SaII. TaqI identifies a 2 allele polymorphism with a band at 2.1 kb and 1.8 kb with a frequency of 0.97 and 0.03 respectively. There are no constant bands. The probe was assigned to chromosome 13 using a linkage analysis with retinoblastoma. Co-dominant inheritance was shown in 3 CEPH pedigrees.

  9. Increased incidence and disparity of diagnosis of retinoblastoma patients in Guatemala

    Science.gov (United States)

    Bendfeldt, Giovana; Lou, Hong; Giron, Veronica; Garrido, Claudia; Valverde, Patricia; Barnoya, Margarita; Castellanos, Mauricio

    2014-01-01

    Analysis of 327 consecutive cases at a pediatric referral hospital of Guatemala reveals that retinoblastoma accounts for 9.4% of all cancers and the estimated incidence is 7.0 cases/million children, higher than the United States or Europe. The number of familial cases is low, and there is a striking disparity in indigenous children due to late diagnosis, advanced disease, rapid progression and elevated mortality. Nine germline mutations in 18 patients were found; two known and five new mutations. Hypermethylation of RB1 was identified in 13% of the tumors. An early diagnosis program could identify cases at an earlier age and improve outcome of retinoblastoma in this diverse population. PMID:24814393

  10. A palliative approach for rehabilitation of a pediatric patient with retinoblastoma

    Directory of Open Access Journals (Sweden)

    Himanshi Aggarwal

    2013-01-01

    Full Text Available Retinoblastoma is a highly malignant neoplasm. Most of the cases are usually far advanced at the time of detection, requiring enucleation to salvage the child′s life. However, the cosmetic rehabilitation of these patients should always be an integral part of their treatment, which helps in their re-integration in the society. This paper presents a case of 5-year-old patient who had undergone enucleation of her left eye due to retinoblastoma. A multidisciplinary approach, including ophthalmologist, psychotherapist, and a prosthodontist, was adopted to meet her physical, psychological, functional, emotional, social, and cosmetic demands. The patient was rehabilitated cosmetically with precisely fabricated ocular prosthesis. An ocular prosthesis is a highly positive and non-invasive approach to improve the cosmetic appearance and psychological well-being of patient.

  11. Isolated lower extremity metastases, 9 years after initial diagnosis of retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Mulligan, M.E.; Smith, S.E. [University of Maryland, Department of Radiology, Medical School, Baltimore, MD (United States); McCarthy, E.F. [Johns Hopkins Hospital, Department of Pathology, Baltimore, MD (United States)

    2006-10-15

    We report the development of isolated lower extremity metastases, in a child, 9 years after her initial diagnosis and treatment of bilateral infantile retinoblastomas. The radiographic, scintigraphic, computed tomographic, and magnetic resonance imaging findings are discussed. The dominant metastatic focus was blastic, involving the medial cuneiform. Additional occult lesions were found in the base of the second metatarsal, middle cuneiform, navicular and tibial diaphysis. An open biopsy confirmed the diagnosis. The occurrence of late distant metastases is rare in the USA. (orig.)

  12. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein

    DEFF Research Database (Denmark)

    Zhu, L; van den Heuvel, S; Helin, K

    1993-01-01

    The cellular protein p107 shares many structural and biochemical features with the retinoblastoma gene product, pRB. We have isolated a full-length cDNA for human p107 and have used this clone to study the function of p107. We show that, like pRB, p107 is a potent inhibitor of E2F-mediated trans...

  13. Calidad del sueño en una población adulta expuesta al ruido del Aeropuerto El Dorado, Bogotá, 2012

    Directory of Open Access Journals (Sweden)

    Lina María Callejas

    2015-08-01

    Conclusiones. Los habitantes de la localidad presentaron mala calidad del sueño por exposición al ruido, siendo la operación aeroportuaria una de las principales fuentes generadoras. Es necesario revisar las estrategias de mitigación de ruido en la localidad y considerar las implicaciones de la ampliación del Aeropuerto El Dorado para la salud pública.

  14. Clinical presentation of intraocular retinoblastoma; 5-year hospital-based registry in Egypt

    International Nuclear Information System (INIS)

    El Zomor, H.; Nour, R.; Alieldin, A.; Taha, H.; Montasr, M.M.; Moussa, E.; El Nadi, E.; Alfaar, A.S.; Alfaar, A.S.; El Zomor, H.; Taha, H.; Alieldin, A.; Montasr, M.M.; Moussa, E.; El Nadi, E.; Ezzat, S.

    2015-01-01

    Purpose: To study the presenting signs of Retinoblastoma in Egypt at Egypt’s main pediatric oncology referral center. Methods: This is a prospective descriptive study (hospital-based registry) conducted at Children’s Cancer Hospital Egypt between July 2007 and December 2012. Results: Out of 262 patients diagnosed with retinoblastoma, 244 were suffering from intra-ocular disease at presentation. One hundred thirty-nine (57%) patients presented with unilateral disease, while 105 (43%) suffered bilateral disease. The mean age at presentation was 20.6 ± 17 months, averaging 18.87 ± 11.76 months for bilateral and 25.72 ± 18.78 months for unilateral disease. The most common clinical presentation was leukocoria in 180 (73.8%) patients, strabismus in 32 (13.1%) patients and decreased visual acuity in 12 (4.9%) patients. Group D and E disease represented 62% of all affected eyes. Patients with advanced disease (Group C–E) had longer duration of symptoms.Conclusion: In Egypt, retinoblastoma patients present more frequently with advanced disease. There is an ever-increasing need to develop a national team dedicated to studying disease significance and formulating a national awareness program.

  15. Quantification of lacrimal function after D-shaped field irradiation for retinoblastoma

    International Nuclear Information System (INIS)

    Imhof, S.M.; Tan, K.E.W.P.; Hofman, P.

    1993-01-01

    To study the quantitative effects of mega-voltage external beam irradiation in a D-shaped field in patients with retinoblastoma, biomicroscopy was performed in 61 patients and tear function tests (Schirmer-lactoferrin and lysozyme tests) on 45 eyes in 34 irradiated patients. The results were compared with those obtained in 25 non-irradiated control eyes. The Schirmer test was significantly diminished in irradiated eyes, as were the lactoferrin and lysozyme values. A mild to severe keratitis was found in 17 of the 61 patients (28%). A significant correlation (p<0.005) was found between the severe keratitis and the mean Schirmer values; the mean lactoferrin and lysozyme values were diminished in all patients but did not correlate significantly with the corneal abnormalities. These quantitative data, obtained in patients treated for retinoblastoma, affirm the qualitative data found in patients irradiated for other reasons such as orbital or sinus tumours. Irradiation for retinoblastoma is not a harmless treatment and serious late side effects have to be considered. (Author)

  16. Insights on ornithine decarboxylase silencing as a potential strategy for targeting retinoblastoma.

    Science.gov (United States)

    Muthukumaran, Sivashanmugam; Bhuvanasundar, Renganathan; Umashankar, Vetrivel; Sulochana, K N

    2018-02-01

    Ornithine Decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and is reported to be up regulated in several cancers. However, the effect of ODC gene silencing in retinoblastoma is to be understood for utilization in therapeutic applications. Hence, in this study, a novel siRNA (small interference RNA) targeting ODC was designed and validated in Human Y79 retinoblastoma cells for its effects on intracellular polyamine levels, Matrix Metalloproteinase 2 & 9 activity and Cell cycle. The designed siRNA showed efficient silencing of ODC mRNA expression and protein levels in Y79 cells. It also showed significant reduction of intracellular polyamine levels and altered levels of oncogenic LIN28b expression. By this study, a regulatory loop is proposed, wherein, ODC silencing in Y79 cells to result in decreased polyamine levels, thereby, leading to altered protein levels of Lin28b, MMP-2 and MMP-9, which falls in line with earlier studies in neuroblastoma. Thus, by this study, we propose ODC silencing as a prospective strategy for targeting retinoblastoma. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  17. Long non-coding RNA H19 suppresses retinoblastoma progression via counteracting miR-17-92 cluster.

    Science.gov (United States)

    Zhang, Aihui; Shang, Weiwei; Nie, Qiaoli; Li, Ting; Li, Suhui

    2018-04-01

    Long non-coding RNAs (lncRNAs) are frequently dysregulated and play important roles in many cancers. lncRNA H19 is one of the earliest discovered lncRNAs which has diverse roles in different cancers. However, the expression, roles, and action mechanisms of H19 in retinoblastoma are still largely unknown. In this study, we found that H19 is downregulated in retinoblastoma tissues and cell lines. Gain-of-function and loss-of-function assays showed that H19 inhibits retinoblastoma cell proliferation, induces retinoblastoma cell cycle arrest and cell apoptosis. Mechanistically, we identified seven miR-17-92 cluster binding sites on H19, and found that H19 directly bound to miR-17-92 cluster via these seven binding sites. Through binding to miR-17-92 cluster, H19 relieves the suppressing roles of miR-17-92 cluster on p21. Furthermore, H19 represses STAT3 activation induced by miR-17-92 cluster. Hence, our results revealed that H19 upregulates p21 expression, inhibits STAT3 phosphorylation, and downregulates the expression of STAT3 target genes BCL2, BCL2L1, and BIRC5. In addition, functional assays demonstrated that the mutation of miR-17-92 cluster binding sites on H19 abolished the proliferation inhibiting, cell cycle arrest and cell apoptosis inducing roles of H19 in retinoblastoma. In conclusion, our data suggested that H19 inhibits retinoblastoma progression via counteracting the roles of miR-17-92 cluster, and implied that enhancing the action of H19 may be a promising therapeutic strategy for retinoblastoma. © 2017 Wiley Periodicals, Inc.

  18. Profiling safety of intravitreal injections for retinoblastoma using an anti-reflux procedure and sterilisation of the needle track.

    Science.gov (United States)

    Munier, Francis L; Soliman, Sameh; Moulin, Alexandre P; Gaillard, Marie-Claire; Balmer, Aubin; Beck-Popovic, Maja

    2012-08-01

    The preservation of globe integrity has always been a major concern during the treatment of retinoblastoma for fear of extraocular or metastatic spread. Intravitreal chemotherapy has been attempted as a desperate salvage therapy only for eyes with refractory retinoblastoma. Published data on the safety and efficacy of this route are, however, limited. A modified technique of intravitreal injection in eyes with retinoblastoma is described. All children with retinoblastoma who received one or more intravitreal injections using this technique were retrospectively reviewed concerning ocular complications of the injection procedure as well as clinical or histopathological evidence of tumour spread. 30 eyes of 30 children with retinoblastoma received a total of 135 intravitreal injections, with a median follw-up duration of 13.5 months. No extraocular spread was seen on clinical follow-up in any patients and there was no tumour contamination of the retrieved entry sites histopathologically analysed among the five enucleated eyes. No significant ocular side effects were observed except transient localised vitreous haemorrhage (3/135). This technique is potentially safe and effective at a low cost and may play a promising role, especially in the treatment of recurrent and/or resistant vitreous disease in retinoblastoma, as an alternative to enucleation and/or external beam radiotherapy. However, this treatment should not replace the primary standard of care of retinoblastoma and should not be considered in group E eyes. Its application should be approved by an ophthalmological-oncological team and it should be performed by an experienced eye surgeon in a tertiary referral centre after careful selection of a tumour-free injection site.

  19. Outcome of Retinoblastoma Following Limited Sessions of Intra-Arterial Chemotherapy in Iran

    International Nuclear Information System (INIS)

    Ghassemi, Fariba; Ghanaati, Hossein; Karkhaneh, Reza; Boujabadi, Leila; Tabatabaie, Seied Zia; Rajabi, Mohammad Taher

    2014-01-01

    The management of retinoblastoma remains a challenge to the multidisciplinary team, particularly as treatment affects not only visual outcomes, but also ocular retention and morbidity. Management of retinoblastoma has evolved over the past two decades. To report the result of intra-ophthalmic artery chemotherapy (IAC) for the treatment of refractory and advanced retinoblastoma tumors. All patients who had failed to respond adequately to previous treatments and six naive patients with advanced retinoblastoma, receiving IAC between 2009 and 2012, were included in this institutional interventional case series. The patients received 1-2 treatments of IAC given 4-8 weeks apart. Complete response was defined as regressed tumor and complete disappearance of seeding clinically and partial response was defined as partial regression of the tumor with live parts of the tumor and/or lessening of seeds, but not complete disappearance of them clinically. A total of 24 eyes of 24 patients were treated with IAC during the study period. The mean age at the time of IAC was 38.9 months (14-120 months), and the mean follow-up was 16.8 months (3-36 months) after IAC. Tumor control was achieved in 14 eyes (58.3%). Type 3 (combined fleshy and calcified remnants) was the most common type of regression (37.5%). Complications included vitreous hemorrhage in nine eyes (37.5%), arterial occlusion in two (8.3%), cyclitic membrane possibly secondary to ischemia and tractional retinal detachment in one patient (4.2%), chorioretinal atrophy in three (12.5%) patients, and neovascular glaucoma in one eye (4.2%). In eight (33.3%) patients, no complication happened. Globe salvage was achieved in 62.5% of the cases. The success rate for naive patients was 84%. Sixty-seven percent of the cases received transpupillary thermotherapy and cryotherapy before IAC. Intra-ophthalmic artery melphalan is an effective treatment for advanced cases of retinoblastoma, with a reasonable level of success. In the short

  20. Implicaciones de la crianza en la regulación del estrés

    Directory of Open Access Journals (Sweden)

    María Cristina García

    2011-10-01

    Full Text Available The purpose of this article is to revise evidence from human and animal research around the stressregulation pathway. The data from research studies are based on the hypothalamus-pituitary-adrenal gland system andon the way stress early experiences can condition the circuit reactivity. The role of sensible rearing practices to promote the development of adequate self-regulatory systems. Te risk of negligent experiences as well as chronic stress on early childhood.Finally base on existing evidence we propose activities to prevent chronic stress on early childhood.

  1. Accesibilidad y profundidad del sistema financiero : algunas implicaciones para los objetivos de desarrollo y las microfinanzas

    OpenAIRE

    Gutiérrez Goira, Jorge; Unceta Satrustegui, Koldo

    2010-01-01

    Las deficiencias de muchos sistemas financieros locales los hacen excluyentes para amplias capas de población, suponiendo una importante limitación para los procesos de desarrollo. Esta situación ha motivado iniciativas como los programas de microfinanzas, que tratan de ampliar la cobertura de servicios financieros -especilamente el crédito- y avanzar en la lucha contra la pobreza. Sin embargo, la definición de las variables claves que determinan la accesibilidad y los objetivos de desarrollo...

  2. El debate del aborto y sus implicaciones en las legislaciones mundiales

    Directory of Open Access Journals (Sweden)

    Neus Sánchez Expósito

    2010-12-01

    Full Text Available El aborto ha sido siempre un tema complejo que, en la actualidad, sigue suscitando intensos debates desde planteamientos muy dispares y posturas irreconciliables. Detrás de las diferentes líneas argumentativas para legitimar o no la interrupción voluntaria de la gestación existe un análisis de salud sexual y reproductiva desde una óptica moral con una concepción determinada de la “maternidad” que condiciona la jurisprudencia de los diferentes países. Muchas legislaciones permiten el aborto por cuestiones de salud, pero la defensa de la libertad de las mujeres lo reivindica como un derecho humano. Abortion has been always a complex subject still carries on causing heated discussions from very disparate criteria and irreconcilable positions. Behind the different argumentative lines to legitimate, or not, the voluntary termination of pregnancy, there is an analysis on sexual and reproductive health from a moral viewpoint with a certain conception of “motherhood” that conditions all countries’ jurisprudence. Many legislations authorize abortion on heath matters, but the defense of the women’s freedom demands it as a human right.

  3. Demandas y control del trabajo: implicaciones en las unidades de tratamiento intensivo pediatrico y neonatal

    OpenAIRE

    Fogaça, Monalisa de Cássia [UNIFESP; Carvalho, Werther Brunow de [UNIFESP; Nogueira-Martins, Luiz Antonio [UNIFESP

    2010-01-01

    Comparar a demanda e o controle sobre trabalho de médicos e enfermeiros que trabalham em unidades de tratamento intensivo pediátrica e neonatal. Estudo transversal com 37 médicos e 20 enfermeiros. Utilizou-se o Job Content Questionnarie. Médicos da UTI Neonatal diferem em suporte social recebido do supervisor (p=0,01) em relação aos da UTI Pediátrica. Enfermeiros da UTI Neonatal apresentam insegurança no trabalho (p=0,05). Médicos e enfermeiros da UTI Pediátrica diferem em controle sobre o tr...

  4. Implicaciones de la firma del Tratado de Libre Comercio entre Colombia y los Estados Unidos.

    Directory of Open Access Journals (Sweden)

    Olivier Guyottot

    2010-05-01

    Full Text Available At first sight, the Free Trade Agreement between Colombia and the United States of America seems nothing more than a classic commercial treaty involving a regional South American power and the largest economy in the world. In fact, the real extent of such an agreement goes far beyond economic interest for both countries. In an international context more and more unfriendly towards North American domination, Colombia remains a key political ally in this part of the world for the United States, and a strong support in its crusade against terrorism. On the other hand, the amount of money given by the United States remains vital to the financial and logistical cost of Colombia’s war against drug ‘cartels’ and paramilitary organizations. But if the Colombian government clearly can’t afford to lose such a support, it can’t either let this Free Trade Agreement casts doubts over Colombia’s involvement into the existing process of economic and political integration in South America.

  5. La Resonancia J/$\\psi$ y Sus Implicaciones Para La Masa Del W

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez-Hernandez, Alberto [Mexico, ESFM

    1995-01-01

    Es un placer agradecer a mi asesor el doctor Heriberto Castilla Valdez por brindarme sus conocimientos, experiencia y paciencia en el desarrollo de esta tesis; tambien quiero agradecer al profesor H.E. Fisk, por su apoyo econemico en mi estancia en Fermilab. De igual forma agradezco a los doctores Arturo Fernandez Telles, Miguel Angel Perez Angen y Rebeca Juarez Wisozka quienes me introdujeron al campo de la fisica experimental de altas energfas. Agradezco tambien a Maribel Rios Cruz, Ruben Flores Mendieta, Juan Morales Corona, Fabiola Vazquez Valencia, Salvador Carrillo Moreno y Cecilia Uribe Estrada por su amistad y compaiierismo durante el desarrollo de mi maestria. Un especial agradecimiento a Ian Adam y Kina Denisenko por su valiosa ayuda, comentarios y discusiones durante mi estancia en Fermilab. Por ultimo quisiera agradecer a mis profesores, amigos y familiares quienes siempre me apoyaron y alentaron y al Consejo N acional de Ciencia y Tecnologfa asf como al Departamento de Fisica de Cinvestav por su apoyo econemlco.

  6. Implicaciones del consumo de sustancias psicoactivas sobre la salud de hombres privados de libertad

    Directory of Open Access Journals (Sweden)

    Francisco Caravaca-Sánchez

    2015-07-01

    Conclusiones: La victimización y el consumo de sustancias en prisión son una realidad, y se encuentra una asociación estadísticamente significativa entre ambos fenómenos. Resulta necesario su estudio para el planteamiento de medidas preventivas y mejorar la vida en prisión.

  7. La democracia del futuro

    Directory of Open Access Journals (Sweden)

    Rodrigo Borja

    2015-01-01

    Full Text Available El desarrollo logrado por la informática, la microelectrónica y en general las nuevas tecnologías de la información, hace que del zoon politikon aristotélico se pase al homo digitalis posmoderno, de una "democracia restringida" a una telecracia: en el siglo XXI. El autor vaticina que el voto se hará vía computadores desde casa a través de éstos, los gobernantes podrán tener una relación directa con los gobernados, las consultas populares serán más frecuentes, las implicaciones para los regímenes democráticos serán enormes y es en torno a ellas que reflexiona el autor

  8. Abnormalities in structure and expression of the retinoblastoma gene in small cell lung cancer cell lines and xenografts in nude mice

    DEFF Research Database (Denmark)

    Rygaard, K; Sorenson, G D; Pettengill, O S

    1990-01-01

    The putative retinoblastoma gene (Rb) is a tumor suppressor gene which is believed to cause retinoblastomas when both alleles are inactivated, leading to lack of the encoded Mr 110,000-116,000 phosphoprotein. Inactivation of the Rb gene has also been found in several other tumor types, including...

  9. Leiomyosarcoma of the bladder in a 16-year-old girl with a history of cyclophosphamide therapy for bilateral retinoblastoma during infancy

    International Nuclear Information System (INIS)

    Al-Zahrani, Ali A.; Kamal, Baher A.; Eldarawani, Hamed M.; Hashim, Tariq M.

    2006-01-01

    A 16-year-old female with bladder leiomyosarcoma had a history of bilateral retinoblastoma at 6 months of life. She received cyclophosphamide chemotherapy after surgical enucleation. In this report, we discussed the possible role of retinoblastoma or cyclophosphamide as a target for development of bladder leiomyosarcoma. (author)

  10. La experiencia del proyecto EMILIA en Barcelona. El usuario como experto: concepto, modalidades y experiencia desde el Proyecto Emilia.

    OpenAIRE

    Paz Flores; Carmen Masferrer; Eithne Leahy; Roser Izquierdo; Eduard Palomer

    2010-01-01

    Se relata la experiencia del proyecto EMILIA y se ofrece una visión global de qué se entiende por “usuario experto” y “implicación de los usuarios” en salud mental. Se discuten sus implicaciones para los profesionales, usuarios y el sistema sanitario.

  11. Implicaciones sociales de los sistemas de computadoras telecomunicaciones

    OpenAIRE

    Edwin Parker

    2015-01-01

    La crisis económica de mediados de la década del 70 es un síntoma de una transición social importante. La causa principal es el cambio de las sociedades industrializadas a sociedades post-industrializadas y la introducción resultante, de elementos post-industriales en los procesos de industrialización en los países menos desarrollados. Estamos en medio de una transición, de una sociedad industrial a una sociedad de información; se está ingresando en una era en la cual la actividad predominant...

  12. La categorización y sus implicaciones educativas

    Directory of Open Access Journals (Sweden)

    P. CANOVAS LEONHARDT

    2009-11-01

    Full Text Available Nuestro objetivo en este estudio es explicitar las directrices que enmarcan el relevante proceso de categorización, considerado como uno de los procesos básicos que utiliza el sujeto en el procesamiento de la información. En efecto, clasificamos o categorizamos objetos, acontecimientos, acciones, percepciones, emociones, entidades abstractas y, por supuesto, también realizamos categorizaciones sociales. Ciertamente, sin el concurso de los mencionados procesos no podríamos efectuar, ni enfrentarnos tanto a las solicitaciones y exigencias procedentes del mundo físico, como a aquellas otras elicitaciones suscitadas por la realidad social.

  13. Ad infinitum: implicaciones de lo sublime en la contemporaneidad

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Gaete Cáceres

    2014-12-01

    Full Text Available El presente texto es un estudio que ofrece una revisión crítica al concepto de lo sublime basándose en la teorización clásica de esta idea, es decir, la adjudicada a Longino, Edmund Burke e Immanuel Kant. A partir de aquí, se intentará descubrir la presencia de lo sublime como un factor relevante en la configuración cultural del mundo contemporáneo, pasando por su presencia innegable en el arte de las vanguardias o en la concepción de la Naturaleza y el entorno. Finalmente, el objetivo central de este escrito es demostrar como lo sublime ofrece también una alternativa para comprender el problema de "lo infinito" y "lo ilimitado" en el marco de las tecnologías, la eclosión de las grandes ciudades y su filtración en el sustrato retórico del capitalismo, ofreciendo así una vía diferente en el estudio de este tema clásico de la estética.

  14. Novel retinoblastoma treatment avoids chemotherapy: the effect of optimally timed combination therapy with angiogenic and glycolytic inhibitors on LHBETATAG retinoblastoma tumors

    Directory of Open Access Journals (Sweden)

    Samuel K Houston

    2011-01-01

    Full Text Available Samuel K Houston1, Yolanda Piña1, Timothy G Murray1, Hinda Boutrid1, Colleen Cebulla2, Amy C Schefler1, Wei Shi1, Magda Celdran1, William Feuer1, Jaime Merchan3, Ted J Lampidis41Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; 2Department of Ophthalmology, The Ohio State University, Columbus, OH, USA; 3Division of Hematology/Oncology, Department of Medicine, 4Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL, USAPurpose: The purpose of this study was to evaluate the effect of optimally timed combination treatment with angiogenic and glycolytic inhibitors on tumor burden, hypoxia, and angiogenesis in advanced retinoblastoma tumors.Methods: LHBETATAG mice (n = 30 were evaluated. Mice were divided into 5 groups (n = 6 and received injections at 16 weeks of age (advanced tumors with a saline, b anecortave acetate (AA, c 2-deoxyglucose (2-DG, d AA + 2-DG (1 day post-AA treatment, or e AA + 2-DG (1 week post-AA treatment. Eyes were enucleated at 21 weeks and tumor sections were analyzed for hypoxia, angiogenesis, and tumor burden.Results: Eyes treated with 2-DG 1 day post-AA injection showed a 23% (P = 0.03 reduction in tumor burden compared with 2-DG alone and a 61% (P < 0.001 reduction compared with saline-treated eyes. Eyes treated with 2-DG 1 week post-AA injection showed no significant decrease in tumor burden compared with 2-DG alone (P = 0.21 and a 56% (P < 0.001 decrease in comparison with saline-treated eyes. 2-DG significantly reduced the total density of new blood vessels in tumors by 44% compared to saline controls (P < 0.001, but did not affect the density of mature vasculature.Conclusions: Combination therapy with angiogenic and glycolytic inhibitors significantly enhanced tumor control. Synergistic effects were shown to be dependent on the temporal course of treatment

  15. ¿Fue Wittgenstein un conductista? La necesidad de criterios públicos para el juego de lenguaje de lo ?interno? y sus implicaciones para la Psicología

    Directory of Open Access Journals (Sweden)

    Antonio Crego Díaz

    2004-11-01

    Full Text Available Se argumenta a favor de una interpretación conductista de Wittgenstein, caracterizando esta postura como ?conductismo epistemológico? ?referido a juegos de lenguaje-, que no niega ?en el plano ontológico- la existencia de lo mental, que interpreta la conducta en sentido amplio y que tiene un marcado carácter social. En la base de este conductismo se encuentra la idea de que para establecer el juego de lenguaje de lo interno se precisa de criterios públicos, intersubjetivos. Se explora la posibilidad de elaborar una epistemología sociopsicológica naturalizada a partir del análisis lingüístico skinneriano y en consonancia con las observaciones de Wittgenstein. Se comentan las implicaciones del conductismo epistemológico para el lenguaje de los términos psicológicos.

  16. Transcriptional regulatory program in wild-type and retinoblastoma gene-deficient mouse embryonic fibroblasts during adipocyte differentiation

    DEFF Research Database (Denmark)

    Hakim-Weber, Robab; Krogsdam, Anne-M; Jørgensen, Claus

    2011-01-01

    Although many molecular regulators of adipogenesis have been identified a comprehensive catalogue of components is still missing. Recent studies showed that the retinoblastoma protein (pRb) was expressed in the cell cycle and late cellular differentiation phase during adipogenesis. To investigate...... this dual role of pRb in the early and late stages of adipogenesis we used microarrays to perform a comprehensive systems-level analysis of the common transcriptional program of the classic 3T3-L1 preadipocyte cell line, wild-type mouse embryonic fibroblasts (MEFs), and retinoblastoma gene-deficient MEFs...... of experimental data and computational analyses pinpointed a feedback-loop between Pparg and Foxo1.To analyze the effects of the retinoblastoma protein at the transcriptional level we chose a perturbated system (Rb-/- MEFs) for comparison to the transcriptional program of wild-type MEFs. Gene ontology analysis...

  17. Implicaciones de la Intoxicación por Mercurio.

    Directory of Open Access Journals (Sweden)

    Myriam Gutiérrez de Salazar

    2004-06-01

    Full Text Available

    Generalidades

    El mercurio puede encontrarse en diversidad de minerales, yacimientos y en una gran variedad de estados físicos y químicos, cada uno de ellos tiene toxicidad diferente y sus aplicaciones en la industria, la agricultura y la medicina requiere de distintas evaluaciones. En Colombia es de gran importancia su estudio por el uso indiscriminado que se hace del mercurio metálico durante los procesos de “amalgamación” del oro durante la actividad minera de extracción de oro en varias zonas de nuestro país, constituyendo un riesgo tóxico para los seres humanos y todos los ecosistemas terrestres y acuáticos. Estados del mercurio

    • Mercurio metálico o elemental, es usado en la extracción de oro y plata, en amalgamas dentales y en una gran variedad de elementos de medición de temperatura y presión en medicina y en la industria.

    • Mercurio inorgánico o Sales de Mercurio son utilizadas como antiséptico en quemaduras, y fueron alguna vez utilizadas como diuréticos.

    • Organomercuriales, han sido utilizados como fungicidas y antisépticos. El más importante desde el punto de vista tóxico es el metilmercurio, el cual puede acumularse en las especies acuáticas debido a la contaminación ambiental. En los años cincuenta una planta química cercana a la Bahía de Minamata (Japón descargó alta cantidad de residuos mercuriales en el mar, lo cual contaminó el plancton y el pescado que fue consumido posteriormente por los habitantes locales, originando una intoxicación masiva de características catastróficas, con 121 afectados, 46 muertos y muchos niños con daños severos en el sistema nervioso central...

  18. Estudo do raspado de conjuntiva de pacientes tratados de retinoblastoma: Etapa II -- citologia Study of conjunctival scrape smears in patients treated for retinoblastoma: Phase II - cytology

    Directory of Open Access Journals (Sweden)

    Maria Carmen Menezes Santos

    2002-06-01

    Full Text Available Objetivo: A citologia da conjuntiva humana tem sido amplamente estu-dada. A falta de dados sobre as características do raspado ocular em pacientes tratados de retinoblastoma submetidos à enucleação e radioterapia foi o que motivou este estudo. Métodos: Foram examinadas 114 órbitas de 58 pacientes. Este trabalho apresenta os resultados da citologia conjuntival, em 4 condições, com e sem enucleação, com e sem radioterapia. Resultados: No infiltrado leucocitário das órbitas com bulbo ocular predominaram os linfócitos e nas demais, os polimorfonucleares neutrófilos. De maneira geral, as alterações das células epiteliais mais encontradas nas lâminas dos esfregaços conjuntivais de órbitas irradiadas foram: células com núcleo aumentado e nucléolo proeminente e com hialinização do citoplasma. Conclusão: Os achados citológicos do raspado conjuntival não indicaram perfil característico e distinto para cada grupo.Purpose: Human conjunctival cytology has been extensively studied. Lack of data about the characteristics of conjunctival smears in patients treated for retinoblastoma who underwent enucleation and radiotherapy motivated this study. Methods: A previously studied group of 114 orbits of 58 patients was examined. The authors present the results of conjunctival cytology in 4 different situations, with and without enucleation, with and without radiotherapy. Results: In the leukocytic infiltrate in orbits with ocular bulbi predominated the lymphocyte, while in the others predominated the polymorphonuclear neutrophil. In general, the majority of epithelial cell alterations seen in the conjunctival smears of irradiated orbits were: cell with large nuclei, prominent nucleoli, and cytoplasmatic hyalinization. Conclusion: The cytological findings of the conjunctival smears do not indicate a characteristic and distinct pattern for each group.

  19. Worldwide enucleation techniques and materials for treatment of retinoblastoma: an international survey.

    Directory of Open Access Journals (Sweden)

    Daphne L Mourits

    Full Text Available To investigate the current practice of enucleation with or without orbital implant for retinoblastoma in countries across the world.A digital survey identifying operation techniques and material used for orbital implants after enucleation in patients with retinoblastoma.We received a response of 58 surgeons in 32 different countries. A primary artificial implant is routinely inserted by 42 (72.4% surgeons. Ten (17.2% surgeons leave the socket empty, three (5.2% decide per case. Other surgeons insert a dermis fat graft as a standard primary implant (n=1, or fill the socket in a standard secondary procedure (n=2; one uses dermis fat grafts and one artificial implants. The choice for porous implants was more frequent than for non-porous implants: 27 (58.7% and 15 (32.6%, respectively. Both porous and non-porous implant types are used by 4 (8.7% surgeons. Twenty-five surgeons (54.3% insert bare implants, 11 (23.9% use separate wrappings, eight (17.4% use implants with prefab wrapping and two insert implants with and without wrapping depending on type of implant. Attachment of the muscles to the wrapping or implant (at various locations is done by 31 (53.4% surgeons. Eleven (19.0% use a myoconjunctival technique, nine (15.5% suture the muscles to each other and seven (12.1% do not reattach the muscles. Measures to improve volume are implant exchange at an older age (n=4, the use of Restylane SQ (n=1 and osmotic expanders (n=1. Pegging is done by two surgeons.No (worldwide consensus exists about the use of material and techniques for enucleation for the treatment of retinoblastoma. Considerations for the use of different techniques are discussed.

  20. A retinoblastoma orthologue is required for the sensing of a chalone in Dictyostelium discoideum.

    Science.gov (United States)

    Bakthavatsalam, Deenadayalan; White, Michael J V; Herlihy, Sarah E; Phillips, Jonathan E; Gomer, Richard H

    2014-03-01

    Retinoblastoma-like proteins regulate cell differentiation and inhibit cell proliferation. The Dictyostelium discoideum retinoblastoma orthologue RblA affects the differentiation of cells during multicellular development, but it is unclear whether RblA has a significant effect on Dictyostelium cell proliferation, which is inhibited by the secreted proteins AprA and CfaD. We found that rblA⁻ cells in shaking culture proliferate to a higher density, die faster after reaching stationary density, and, after starvation, have a lower spore viability than wild-type cells, possibly because in shaking culture, rblA⁻ cells have both increased cytokinesis and lower extracellular accumulation of CfaD. However, rblA⁻ cells have abnormally slow proliferation on bacterial lawns. Recombinant AprA inhibits the proliferation of wild-type cells but not that of rblA⁻ cells, whereas CfaD inhibits the proliferation of both wild-type cells and rblA⁻ cells. Similar to aprA⁻ cells, rblA⁻ cells have a normal mass and protein accumulation rate on a per-nucleus basis, indicating that RblA affects cell proliferation but not cell growth. AprA also functions as a chemorepellent, and RblA is required for proper AprA chemorepellent activity despite the fact that RblA does not affect cell speed. Together, our data indicate that an autocrine proliferation-inhibiting factor acts through RblA to regulate cell density in Dictyostelium, suggesting that such factors may signal through retinoblastoma-like proteins to control the sizes of structures such as developing organs or tumors.

  1. A retrospective review of visual outcome and complications in the treatment of retinoblastoma.

    LENUS (Irish Health Repository)

    O'Doherty, M

    2005-01-01

    The aim of this study was to look at the visual outcome and treatment complications of children diagnosed with Retinoblastoma during the years 1985-2003 inclusive. A retrospective review of all patients records was performed. Patient characteristics, treatment methods and complications were recorded. Twenty eight children presented to Temple street Hospital between 1985-2003. Six of these infants had bilateral tumours. The mean age at presentation was 23.7 months. Sixty-nine percent presented with Leucocoria, of these 33% also had a squint. The mean duration of symptoms was only known in 58% and this figure was approximately 19.8 months. Enucleation was performed in 24 eyes of 24 patients. Three patients required adjuvant chemotherapy post enucleation. Two eyes was treated with external beam radiation and one eye with plaque radiotherapy. One eye (second eye) was treated with systemic chemotherapy and radiation. Five eyes of three patients were treated with systemic chemotherapy followed by adjuvant Argon laser, cryotherapy and diode laser to each eye.The complications of each treatment group was recorded. The visual outcome in the salvaged eyes was favourable. There were no deaths recorded. Though chemotherapy with adjuvant local treatments provide adequate treatment for early tumours, enucleation still plays a major role in the treatment of Retinoblastoma. The total eye salvage rate in this study was 29% with an enucleation rate of 90% in unilateral cases and 33% in bilateral cases. Sixty-six percent of bilateral eyes affected were salvaged. Seventy-one percent of tumours were diagnosed after a parent noticed a gross abnormality of the eye. This highlights the possible need for screening for retinoblastoma in the infant population.

  2. Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes.

    Directory of Open Access Journals (Sweden)

    Xiaoyun Wu

    Full Text Available The retinoblastoma (Rb tumor suppressor acts with a number of chromatin cofactors in a wide range of species to suppress cell proliferation. The Caenorhabditis elegans retinoblastoma gene and many of these cofactors, called synMuv B genes, were identified in genetic screens for cell lineage defects caused by growth factor misexpression. Mutations in many synMuv B genes, including lin-35/Rb, also cause somatic misexpression of the germline RNA processing P granules and enhanced RNAi. We show here that multiple small RNA components, including a set of germline-specific Argonaute genes, are misexpressed in the soma of many synMuv B mutant animals, revealing one node for enhanced RNAi. Distinct classes of synMuv B mutants differ in the subcellular architecture of their misexpressed P granules, their profile of misexpressed small RNA and P granule genes, as well as their enhancement of RNAi and the related silencing of transgenes. These differences define three classes of synMuv B genes, representing three chromatin complexes: a LIN-35/Rb-containing DRM core complex, a SUMO-recruited Mec complex, and a synMuv B heterochromatin complex, suggesting that intersecting chromatin pathways regulate the repression of small RNA and P granule genes in the soma and the potency of RNAi. Consistent with this, the DRM complex and the synMuv B heterochromatin complex were genetically additive and displayed distinct antagonistic interactions with the MES-4 histone methyltransferase and the MRG-1 chromodomain protein, two germline chromatin regulators required for the synMuv phenotype and the somatic misexpression of P granule components. Thus intersecting synMuv B chromatin pathways conspire with synMuv B suppressor chromatin factors to regulate the expression of small RNA pathway genes, which enables heightened RNAi response. Regulation of small RNA pathway genes by human retinoblastoma may also underlie its role as a tumor suppressor gene.

  3. O uso da quimioterapia no tratamento do retinoblastoma: avaliação retrospectiva The use of chemotherapy in the treatment of retinoblastoma: retrospective analysis

    Directory of Open Access Journals (Sweden)

    Fernando Leite Kronbauer

    2000-12-01

    Full Text Available Objetivo:Análise retrospectiva de pacientes com retinoblastoma considerando: 1 - estadiamento e apresentação tumoral à tomografia, 2 - proporção de pacientes com margens comprometidas (nervo óptico no exame anatomopatológico dos olhos enucleados e 3-tratamento com quimioterapia. Métodos: Revisados os prontuários de 11 pacientes consecutivos com diagnóstico de retinoblastoma entre fevereiro/98 e setembro/99, tratados conjuntamente no setor de Oncologia Pediátrica e Serviço de Oftalmologia. Foram selecionados aqueles submetidos à quimioterapia com vincristina, etoposida e carboplatina (VEC num total de 7 pacientes. Foram avaliados: apresentação tumoral (estadiamento, resposta à quimioterapia e sobrevida destes pacientes. Resultados: Os 7 pacientes estudados foram diagnosticados entre 15 e 38 meses de idade (média=25,7 meses, sendo 3 unilaterais, 3 bilaterais e 1 trilateral (pinealoblastoma. Todos pacientes foram tratados com quimioterapia (VEC administrados em 2 a 5 ciclos e divididos em 2 grupos: Grupo 1 - Pacientes tratados com quimioterapia primária visando redução tumoral e preservação de 1 dos olhos (5 pacientes; Grupo 2 - Pacientes tratados com quimioterapia agressiva para doença extra-ocular (2 pacientes. Dos 5 pacientes tratados com quimioterapia primária (4 submetidos a enucleação devido ao grande volume tumoral, 4 obtiveram redução tumoral, 2 responderam apenas inicialmente indo à óbito em 10 meses de média e 1 apresentou-se quimiorresistente. Pacientes com tumor bilateral foram submetidos a radioterapia (EBTR no olho menos acometido. O tempo médio de seguimento após quimioterapia primária foi 12,4 meses. Os dois pacientes submetidos à enucleação e quimioterapia adjuvante, apresentavam metástase cerebral e foram a óbito em média 4/5 meses após início do tratamento. Conclusão: Esse estudo revelou que: 1-os casos de retinoblastoma são diagnosticados tardiamente em nosso meio. 2 - A porcentagem

  4. Tendencias de especialización maquiladora: implicaciones de la configuración socio-técnica en Nogales, Sonora

    Directory of Open Access Journals (Sweden)

    Araceli Almaraz Alvarado

    1998-01-01

    Full Text Available En este trabajo se discute la posibilidad de incluir en el análisis de la industria maquiladora de exportación (I M E , las implicaciones de la movilidad espacial de las empresas en el proceso de especialización. Partiendo de la importancia del proceso de configuración socio-técnica en la I M E, se busca identificar su correspondencia con el proceso de interacción y expansión de las plantas, a través de las particularidades locales y diferencias entre los tipos de firmas de la I M E concentrada en la ciudad de Nogales, Sonora. A lo largo del artículo se desarrolla la idea de que debe existir una diferenciación entre localidades y / o regiones donde la IME se ha venido desenvolviendo, la cual, finalmente, deberá responder a la urgencia de presentar tipologías de trayectorias industriales que reflejen las tendencias de organización de la producción local y regional, y sus conexiones al ámbito de las cadenas globales.

  5. Induction of growth stimulation in skin fibroblasts from retinoblastoma donors after ionizing radiation

    International Nuclear Information System (INIS)

    Diatloff-Zito, C.; Macieira-Coelho, A.; Turleau, C.; Cabanis, M.O.; Grouchy, J. de

    1983-01-01

    Skin fibroblasts from normal children and two children with a 13q14 deletion retinoblastoma (Rb) were submitted to fractionated doses of γ radiations. Irradiation reduced the population doublings in normal fibroblasts and the decline was inversely related to the dose. An increase in population doublings was obtained with one of the Rb cell lines. Foci appeared in the irradiated culture of the other Rb donor. It is suggested that fibroblasts from patients with Rb are able to express some phenotypical properties of transformed cells, perhaps related to factors rendering them more susceptible to carcinogens [fr

  6. Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma

    DEFF Research Database (Denmark)

    Helin, K; Holm, K; Niebuhr, A

    1997-01-01

    107, or p130 leads to growth arrest in the G1 phase of the cell cycle, and this arrest is abolished by complex formation with the adenovirus E1A, human papilloma virus E7, or simian virus 40 T oncoproteins. Inactivation of pRB by gross structural alterations or point mutations in the RB-1 gene has...... been described in a variety of human tumors, including retinoblastomas, osteosarcomas, and small cell lung carcinomas. Despite the structural and functional similarity between pRB, p107, and p130, alterations in the latter two proteins have not been identified in human tumors. We have screened a panel...

  7. A delayed diagnosis of unsuspected retinoblastoma in an in vitro fertilisation infant with retinopathy of prematurity

    Institute of Scientific and Technical Information of China (English)

    Tian Tian; Xun-Da Ji; Qi Zhang; Jie Peng; Pei-Quan Zhao

    2016-01-01

    Dear Editor,Iam Dr.Tian Tian,from the Department of Ophthalmology,Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China.I write to present a rare case report of a delayed diagnosis of unsuspected retinoblastoma(RB)in an in vitro fertilisation(IVF)infant with retinopathy of prematurity.The simultaneous presentation of RB and prematurity of retinopathy(ROP)in an IVF infant is very rare.The relationship between RB and IVF is still indeterminate and mechanisms that lead to ocular or systemic abnormalities

  8. Danish retinoblastoma patients 1943-2013 - genetic testing and clinical implications

    DEFF Research Database (Denmark)

    Gregersen, Pernille A; Urbak, Steen F; Funding, Mikkel

    2015-01-01

    , the rate has been stable around 1 per 14 000 live births with 95% of the patients surviving their retinoblastoma. Stratifying data on the time of diagnosis and status of genetic testing, the number of screened patients gradually increased from 5% in the beginning of the period to 96% in the last five...... to offspring and elevated risk of second primary cancers, we recommend information and access to genetic counseling and RB1 screening. This has ethical, psychological and possible economic consequences, and should be handled with caution...

  9. Long-term visual results in eyes cured for retinoblastoma by radiation

    International Nuclear Information System (INIS)

    Holbek, S.; Ehlers, N.

    1989-01-01

    Twenty-four eyes from 18 patients cured for retinoblastoma by radiation on an average 12 years previously, were re-examined with respect to visual performance. The macular functions, i.e. visual acuity, colour vision and contrast sensitivity demonstrated performances predictable from tumour localization and radiation dose to the macula. The rod functions, i.e. visual field and dark adaptation were found to be relatively resistant to the radiation treatment. A special problem encountered in two-eyed patients was the unavoidable amblyopia dut to unequal handicaps in the two eyes at the vulnerable age. (author)

  10. Long-term visual results in eyes cured for retinoblastoma by radiation

    Energy Technology Data Exchange (ETDEWEB)

    Holbek, S.; Ehlers, N. (Department of Ophthalmology, Aarhus University Hospital, Aarhus (Denmark))

    1989-01-01

    Twenty-four eyes from 18 patients cured for retinoblastoma by radiation on an average 12 years previously, were re-examined with respect to visual performance. The macular functions, i.e. visual acuity, colour vision and contrast sensitivity demonstrated performances predictable from tumour localization and radiation dose to the macula. The rod functions, i.e. visual field and dark adaptation were found to be relatively resistant to the radiation treatment. A special problem encountered in two-eyed patients was the unavoidable amblyopia dut to unequal handicaps in the two eyes at the vulnerable age. (author).

  11. Recent decreasing frequency of enucleation for intraocular retinoblastoma in Upper Egypt

    International Nuclear Information System (INIS)

    Abdallh, A.M.

    2006-01-01

    To evaluate the efficacy of combined systematic chemotherapy (chemoreduction) and local ophthalmic therapy (LT) is preventing or delaying external beam radiotherapy (EBRT) and enucleation in patients with intraocular retinoblastoma. This was a prospective, nonrandomized, single-institution, clinical study. Twenty-eight patients (37 eyes) with newly diagnosed intraocular retinoblastoma were included in this study. Primary enucleation was performed for 7 eyes with advanced intraocular retinoblastoma at presentation before starting chemoreduction. Using Reese-Ellsworth (RE) staging for RB, the remaining 30 eyes were as follows: Two in group I, 3 in group II, 8 in group III, 7 in group IV, and 9 in group V. All the 30 eyes were initially treated with 6 cycles of chemoredution using vincristine, etoposide and carboplatin, repeated every three weeks. After total of 6 cycles, each tumor was re-evaluated decide on the next mode of therapy. In cases where the tumor was reduced enough, LT (Thermotherapy, or cryotherapy, but plaque radiotherapy was unavailable) was applied. In cases where the tumor was reduced but insufficient for LT, we added another 3 cycles of same regimen in some patients; or we performed chemotherapy (CTT) for others, according to size of the residual tumor. Eyes failed to respond to tochemorduction and LT, received EBRT or were enucleated. Following 6 cycles of chemoreduction, all tumors showed an initial regression, and all vitreous and subretinal seeds showed calcification or disappearance of most of them. Among the 30 eyes, 12 eyes achieved complete response (CR), and 18 eyes achieved partial response (PR). Only 7 eyes (stage I to III) showed sufficient reduction of tumor size for the LT to be applied for, for which, TTT (4 eyes), and cryotherapy (3 eyes) were performed. Chemotherapy (CTT) was performed for 9 patients (13 eyes, 15 tumors). At the end of follow-up period, 14 of the total 30 eyes (46.7%) could not be salvaged with chemoreduction and LT

  12. X-ray sensitivity of fibroblasts from patients with hereditary retinoblastoma and their families.

    OpenAIRE

    Pledger, J. V.; Craft, A. W.; Bartlett, K.; Long, D. R.

    1987-01-01

    The in vitro response to X-irradiation of cultured human fibroblasts was studied using a colony forming assay. A comprehensive reference range was established, giving a median D0 value of 98.5 cGy with an interquartile range of 86.5-110.5 cGy. Cells from 3 retinoblastoma family pedigrees were studied and the cell survival after exposure to X-rays was compared between affected (11 samples) and unaffected (26 samples) family members. No significant differences in response to ionising radiation ...

  13. Efficacy and safety of aflibercept in in vitro and in vivo models of retinoblastoma

    Directory of Open Access Journals (Sweden)

    Dong Yoon Kim

    2016-11-01

    Full Text Available Abstract Background To evaluate the inhibitory effects of aflibercept on the growth and subretinal invasion of retinoblastoma. Methods Xenotransplantation and orthotopic mouse models were created by injecting Y-79 cells subcutaneously and intravitreally, respectively. After induction of retinoblastoma, animals were intraperitoneally injected with aflibercept (25 mg/kg body weight or saline twice a week for 3 weeks. Tumor size was measured weekly and compared between the two groups. At 4 weeks, animals were sacrificed and an immunohistochemical examination was conducted to compare the microvascular density and degree of apoptosis between groups. In addition, the degree of choroidal invasion was also analyzed in the orthotopic xenotransplantation model. A co-culture system of Y-79 or WERI-Rb-1 cells and human umbilical vein endothelial cells (HUVECs was used for in vitro experiments, and the anti-angiogenic effect of aflibercept was evaluated by analyzing cell numbers. Results In the Y-79 xenotransplantation model, aflibercept treatment significantly inhibited tumor growth at 4 weeks versus baseline compared with saline-injected mice (188.53 ± 118.53 mm3 vs. 747.87 ± 118.83 mm3, respectively, P < 0.001. Tumors isolated from aflibercept-treated mice contained fewer blood vessels (8.59 % ± 7.60 % vs. 14.91 % ± 4.53 %, respectively, P < 0.05 and an increased number of apoptotic cells (15.10 ± 9.13 vs. 4.44 ± 2.24, respectively, P < 0.05. In the orthotopic model, the degree of subretinal invasion of tumor cells was significantly reduced after aflibercept treatment (0.07 ± 0.06 vs. 0.15 ± 0.10, P < 0.05. And addition of aflibercept to co-cultures of HUVECs and Y-79, WERI-Rb-1 cells significantly reduced HUVEC proliferation. Conclusions Aflibercept reduced retinoblastoma angiogenesis in association with a significant reduction in tumor growth and invasion. These findings suggest that

  14. Efectos del miedo en los trabajadores y la organización

    Directory of Open Access Journals (Sweden)

    Cristian Bedoya Dorado

    2016-01-01

    Full Text Available A partir de la propuesta de Deming sobre erradicar el miedo en el lugar de trabajo, diferentes investigaciones han encontrado que esta emoción es negativa para los trabajadores y las organizaciones. Este artículo tiene como objetivo identificar los efectos que el miedo genera en los trabajadores y en las organizaciones. Para ello, se realizó una revisión bibliográfica sobre los estudios del miedo en la organización y sus implicaciones en el trabajo. De este modo se agruparon los efectos del miedo en el trabajador y en la organización y se analizaron sus implicaciones, a partir de lo cual se encontró que identificar los efectos que tiene el miedo en la organización contribuye a la comprensión del papel que tienen las subjetividades en el contexto organizacional y el funcionamiento de estas.

  15. Implicaciones sociales de los sistemas de computadoras telecomunicaciones

    Directory of Open Access Journals (Sweden)

    Edwin Parker

    2015-05-01

    Full Text Available La crisis económica de mediados de la década del 70 es un síntoma de una transición social importante. La causa principal es el cambio de las sociedades industrializadas a sociedades post-industrializadas y la introducción resultante, de elementos post-industriales en los procesos de industrialización en los países menos desarrollados. Estamos en medio de una transición, de una sociedad industrial a una sociedad de información; se está ingresando en una era en la cual la actividad predominante es el procesamiento de la información y no la producción industrial. El adelanto de las computadoras, las comunicaciones y otras técnicas de información en los últimos 25 años, ha sido llamado, con razón, "la segunda revolución industrial".

  16. comportamiento del consumidor

    Directory of Open Access Journals (Sweden)

    Erico Rentería Pérez

    2006-01-01

    Full Text Available En este artículo se analiza el posicionamiento exitoso de los profesionales, particularmente los jóvenes, a partir de las nuevas realidades del mundo y del mercado laboral, así como la empleabilidad como constructo, estrategias posibles y, finalmente, una discusión sobre falacias y realidades de discursos sobre mercado de trabajo profesional. La reflexión se liga a dos investigaciones, y a redes de discusión en Brasil y Colombia, que reflexionan sobre las implicaciones y requerimientos estratégicos que marcan el ingreso o permanencia en el mercado de trabajo de profesionales jóvenes, y se reconoce que esto afecta a otros tipos de profesionales. La investigación de Rentería (2006ª sobre Empleabilidad arroja información sobre las dos primeras partes. La de Enríquez y Rentería (2006 sobre Estrategias de aprendizaje y empleabilidad informa sobre la tercera. Apoyan la discusión elementos de psicología y comportamiento del consumidor. Se discute la inclusión social y calidad de vida por el trabajo.

  17. COMPLICACIONES PSIQUIÁTRICAS DEL ABORTO

    OpenAIRE

    Manuel Gurpegui; Dolores Jurado

    2009-01-01

    Introducción: Las consecuencias psiquiátricas del aborto inducido siguen siendo objeto de controversia. Las reacciones de cualquier mujer al descubrir que ha concebido pueden ser muy variables. El embarazo, inicialmente intencionado o no deseado, puede provocar estrés; y el aborto espontáneo puede acarrear sentimientos de pérdida y reacciones de duelo, por lo que no es de extrañar que el aborto inducido, con las implicaciones emocionales añadidas (sentimientos de alivio, vergüenza y culpa), s...

  18. Sonic hedgehog initiates cochlear hair cell regeneration through downregulation of retinoblastoma protein

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Na [Otology Skull Base Surgery Department, Hearing Research Institute, Eye and ENT Hospital of Shanghai Medical School, Fudan University, Shanghai 200031 (China); Department of Otolaryngology and Program in Neuroscience, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 (United States); Chen, Yan [Central Laboratory, Hearing Research Institute, Eye and ENT Hospital of Shanghai Medical School, Fudan University, Shanghai 200031 (China); Wang, Zhengmin [Otology Skull Base Surgery Department, Hearing Research Institute, Eye and ENT Hospital of Shanghai Medical School, Fudan University, Shanghai 200031 (China); Institute of Biomedical Sciences, Fudan University, Shanghai 200032 (China); Chen, Guoling [Otology Skull Base Surgery Department, Hearing Research Institute, Eye and ENT Hospital of Shanghai Medical School, Fudan University, Shanghai 200031 (China); Lin, Qin [Otology Skull Base Surgery Department, Hearing Research Institute, Eye and ENT Hospital of Shanghai Medical School, Fudan University, Shanghai 200031 (China); Department of Otolaryngology, First Affiliated Hospital of Fujian Medical University, Otolaryngology Institute of Fujian Province, Fuzhou (China); Chen, Zheng-Yi, E-mail: Zheng-yi_chen@meei.harvard.edu [Department of Otolaryngology and Program in Neuroscience, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 (United States); Li, Huawei, E-mail: hwli@shmu.edu.cn [Otology Skull Base Surgery Department, Hearing Research Institute, Eye and ENT Hospital of Shanghai Medical School, Fudan University, Shanghai 200031 (China); Institute of Biomedical Sciences, Fudan University, Shanghai 200032 (China)

    2013-01-11

    Highlights: Black-Right-Pointing-Pointer Shh activation in neonatal cochleae enhances sensory cell proliferation. Black-Right-Pointing-Pointer Proliferating supporting cells can transdifferentiate into hair cells. Black-Right-Pointing-Pointer Shh promotes proliferation by transiently modulating pRb activity. Black-Right-Pointing-Pointer Shh inhibits pRb by inhibiting transcription and increasing phosphorylation of pRb. -- Abstract: Cell cycle re-entry by cochlear supporting cells and/or hair cells is considered one of the best approaches for restoring hearing loss as a result of hair cell damage. To identify mechanisms that can be modulated to initiate cell cycle re-entry and hair cell regeneration, we studied the effect of activating the sonic hedgehog (Shh) pathway. We show that Shh signaling in postnatal rat cochleae damaged by neomycin leads to renewed proliferation of supporting cells and hair cells. Further, proliferating supporting cells are likely to transdifferentiate into hair cells. Shh treatment leads to inhibition of retinoblastoma protein (pRb) by increasing phosphorylated pRb and reducing retinoblastoma gene transcription. This results in upregulation of cyclins B1, D2, and D3, and CDK1. These results suggest that Shh signaling induces cell cycle re-entry in cochlear sensory epithelium and the production of new hair cells, in part by attenuating pRb function. This study provides an additional route to modulate pRb function with important implications in mammalian hair cell regeneration.

  19. Salvage/Adjuvant Brachytherapy After Ophthalmic Artery Chemosurgery for Intraocular Retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Francis, Jasmine H., E-mail: francij1@mskcc.org [Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Barker, Christopher A.; Wolden, Suzanne L.; McCormick, Beryl; Segal, Kira; Cohen, Gil [Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Gobin, Y. Pierre; Marr, Brian P. [Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Weill-Cornell Medical College, New York-Presbyterian Hospital, New York, New York (United States); Brodie, Scott E. [Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Mount Sinai School of Medicine, New York, New York (United States); Dunkel, Ira J.; Abramson, David H. [Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Weill-Cornell Medical College, New York-Presbyterian Hospital, New York, New York (United States)

    2013-11-01

    Purpose: To evaluate the efficacy and toxicity of brachytherapy after ophthalmic artery chemosurgery (OAC) for retinoblastoma. Methods and Materials: This was a single-arm, retrospective study of 15 eyes in 15 patients treated with OAC followed by brachytherapy at (blinded institution) between May 1, 2006, and December 31, 2012, with a median 19 months' follow-up from plaque insertion. Outcome measurements included patient and ocular survival, visual function, and retinal toxicity measured by electroretinogram (ERG). Results: Brachytherapy was used as adjuvant treatment in 2 eyes and as salvage therapy in 13 eyes of which 12 had localized vitreous seeding. No patients developed metastasis or died of retinoblastoma. The Kaplan-Meier estimate of ocular survival was 79.4% (95% confidence interval 48.7%-92.8%) at 18 months. Three eyes were enucleated, and an additional 6 eyes developed out-of-target volume recurrences, which were controlled with additional treatments. Patients with an ocular complication had a mean interval between last OAC and plaque of 2.5 months (SD 2.3 months), which was statistically less (P=.045) than patients without ocular complication who had a mean interval between last OAC and plaque of 6.5 months (SD 4.4 months). ERG responses from pre- versus postplaque were unchanged or improved in more than half the eyes. Conclusions: Brachytherapy following OAC is effective, even in the presence of vitreous seeding; the majority of eyes maintained stable or improved retinal function following treatment, as assessed by ERG.

  20. Comparison of the diagnostic value of MR imaging and ophthalmoscopy for the staging of retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Khurana, Aman; Wan, Wenshuai; Yeom, Kristen [Stanford University, Department of Radiology, Stanford, CA (United States); Eisenhut, Christina A. [Technical University of Munich, Department of Radiology, Munich (Germany); Ebrahimi, Katayoon B. [Johns Hopkins University, Department of Ocular Oncology, Baltimore, MD (United States); Patel, Chirag [University of California Davis, Department of Radiology, Davis, CA (United States); O' Brien, Joan M. [University of Pennsylvania, Department of Ophthalmology, Philadelphia, PA (United States); Daldrup-Link, Heike E. [Stanford University, Department of Radiology, Stanford, CA (United States); Stanford University, Department of Radiology, Pediatric Radiology Section, Lucile Packard Children' s Hospital, Stanford, CA (United States)

    2013-05-15

    To compare the diagnostic value of magnetic resonance (MR) imaging and ophthalmoscopy for staging of retinoblastoma. MR and ophthalmoscopic images of 36 patients who underwent enucleation were evaluated retrospectively following institutional review board approval. Histopathology being the standard of reference, the sensitivity and specificity of both diagnostic modalities were compared regarding growth pattern, iris neoangiogenesis, retinal detachment, vitreous seeds and optic nerve invasion. Data were analysed via McNemar's test. Both investigations showed no significant difference in accuracy for the detection of different tumour growth patterns (P = 0.80). Vitreous seeding detection was superior by ophthalmoscopy (P < 0.001). For prelaminar optic nerve invasion, MR imaging showed similar sensitivity as ophthalmoscopy but increased specificity of 40 % (CI 0.12-0.74) vs. 20 % (0.03-0.56). MR detected optic nerve involvement past the lamina cribrosa with a sensitivity of 80 % (0.28-0.99) and a specificity of 74 % (0.55-0.88). The absence of optic nerve enhancement excluded histopathological infiltration, but the presence of optic nerve enhancement included a high number of false positives (22-24 %). Ophthalmoscopy remains the method of choice for determining extent within the globe while MR imaging is useful for evaluating extraocular tumour extension. Thus, both have their own strengths and contribute uniquely to the staging of retinoblastoma. (orig.)

  1. Managing the consequences of aggressive conservative treatment for refractory retinoblastoma with vitreous seeding

    Directory of Open Access Journals (Sweden)

    Aubrey Brink

    2014-08-01

    Full Text Available A 4 year-old girl with bilateral, non-familial retinoblastoma (RB was referred to our care after primary enucleation OS and active tumor OD refractory to multiple therapies (intravenous chemotherapy, laser/cryotherapy, and I-125 plaque radiotherapy. Vitreous seeding OD, initially controlled by several sessions of Ophthalmic Artery Infusion Chemotherapy (OAIC and periocular chemotherapy, recurred shortly thereafter. The patient underwent intravitreal (IVit Melphalan injections achieving tumor control despite the concurrent development of keratopathy, pupillary synechiae, cataract, and necrosis of the inferior fornix and the adjacent orbital fat, all secondary to the treatments administered. Repeated amniotic membrane implants and tarsorrhaphy were performed to alleviate the symptoms. Despite being tumor free for 6 months, a poor fundus view and treatment-related complications prompted us to consider enucleation, but parents declined. Following recent negative magnetic resonance imaging (MRI, her cataract was removed. She was then found to have tumor recurrence. Her eye was enucleated 12 months ago and she recovered well from the surgery. As ocular oncology embarks in eye-preserving treatments for retinoblastoma, it is important to address the cumulative effects and associated impact of such treatments and the possibility of failure.

  2. Success of intra-arterial chemotherapy (chemosurgery) for retinoblastoma: effect of orbitovascular anatomy.

    Science.gov (United States)

    Marr, Brian P; Hung, Crystal; Gobin, Yves P; Dunkel, Ira J; Brodie, Scott E; Abramson, David H

    2012-02-01

    To review results of orbital angiography performed during intra-arterial chemotherapy (chemosurgery) for treatment of retinoblastoma to assess the association of angiographic variability in orbitovascular anatomy with tumor response and outcomes. Medical records and 64 orbital angiograms were reviewed for 56 pediatric patients with retinoblastoma undergoing chemosurgery using a combination of melphalan hydrochloride, topotecan hydrochloride, or carboplatin. The major orbital arteries and capillary blush patterns were graded, and tumor response and recurrence were compared using the log-rank and Fisher exact tests. Statistically significant variables for tumor response were lacrimal artery prominence (P = .001), previous treatment (P = .003), and lacrimal blush (P = .004). The only statistically significant variable for vitreous seed response was ciliary body blush (P = .03). Statistically significant variables influencing time to recurrence and time to enucleation were choroidal blush absence (P = .01) and lacrimal artery presence (P = .03), respectively. The success of intra-arterial chemotherapy is dependent on delivery of drug to the target tumor within the eye via the ophthalmic artery. Because of the small volume of drug used (0.50-1.25 mL per treatment) and the selectivity of catheterization, variables affecting orbital blood flow greatly influence drug delivery and the success of chemosurgery.

  3. X-ray sensitivity of fibroblasts from patients with hereditary retinoblastoma and their families

    International Nuclear Information System (INIS)

    Pledger, J.V.; Craft, A.W.; Bartlett, K.; Long, D.R.

    1987-01-01

    The in vitro response to X-irradiation of cultured human fibroblasts was studied using a colony forming assay. A comprehensive reference range was established, giving a median Dsub(0) value of 98.5 cGy with an interquartile range of 86.5-110.5 cGy. Cells from 3 retinoblastoma family pedigrees were studied and the cell survival after exposure to X-rays was compared between affected (11 samples) and unaffected (26 samples) family members. No significant differences in response to ionising radiation were found between the controls, the affected and the unaffected members of the 3 families. The affected members had a median Dsub(0) of 97.5 cGy (interquartile range 87.5-107.5 cGy) and the unaffected members had a median Dsub(0) of 102 cGy (interquartile range 93-111 cGy). Thus radiosensitivity is not a useful marker for the detection of the retinoblastoma gene. (author)

  4. Sonic Hedgehog Initiates Cochlear Hair Cell Regeneration through Downregulation of Retinoblastoma Protein

    Science.gov (United States)

    Lu, Na; Chen, Yan; Wang, Zhengmin; Chen, Guoling; Lin, Qin; Chen, Zheng-Yi; Li, Huawei

    2013-01-01

    Cell cycle re-entry by cochlear supporting cells and/or hair cells is considered one of the best approaches for restoring hearing loss as a result of hair cell damage. To identify mechanisms that can be modulated to initiate cell cycle re-entry and hair cell regeneration, we studied the effect of activating the sonic hedgehog (Shh) pathway. We show that Shh signaling in postnatal rat cochleae damaged by neomycin leads to renewed proliferation of supporting cells and hair cells. Further, proliferating supporting cells are likely to transdifferentiate into hair cells. Shh treatment leads to inhibition of retinoblastoma protein (pRb) by increasing phosphorylated pRb and reducing retinoblastoma gene transcription. This results in upregulation of cyclins B1, D2, and D3, and CDK1. These results suggest that Shh signaling induces cell cycle re-entry in cochlear sensory epithelium and the production of new hair cells, in part by attenuating pRb function. This study provides an additional route to modulate pRb function with important implications in mammalian hair cell regeneration. PMID:23211596

  5. Salvage/Adjuvant Brachytherapy After Ophthalmic Artery Chemosurgery for Intraocular Retinoblastoma

    International Nuclear Information System (INIS)

    Francis, Jasmine H.; Barker, Christopher A.; Wolden, Suzanne L.; McCormick, Beryl; Segal, Kira; Cohen, Gil; Gobin, Y. Pierre; Marr, Brian P.; Brodie, Scott E.; Dunkel, Ira J.; Abramson, David H.

    2013-01-01

    Purpose: To evaluate the efficacy and toxicity of brachytherapy after ophthalmic artery chemosurgery (OAC) for retinoblastoma. Methods and Materials: This was a single-arm, retrospective study of 15 eyes in 15 patients treated with OAC followed by brachytherapy at (blinded institution) between May 1, 2006, and December 31, 2012, with a median 19 months' follow-up from plaque insertion. Outcome measurements included patient and ocular survival, visual function, and retinal toxicity measured by electroretinogram (ERG). Results: Brachytherapy was used as adjuvant treatment in 2 eyes and as salvage therapy in 13 eyes of which 12 had localized vitreous seeding. No patients developed metastasis or died of retinoblastoma. The Kaplan-Meier estimate of ocular survival was 79.4% (95% confidence interval 48.7%-92.8%) at 18 months. Three eyes were enucleated, and an additional 6 eyes developed out-of-target volume recurrences, which were controlled with additional treatments. Patients with an ocular complication had a mean interval between last OAC and plaque of 2.5 months (SD 2.3 months), which was statistically less (P=.045) than patients without ocular complication who had a mean interval between last OAC and plaque of 6.5 months (SD 4.4 months). ERG responses from pre- versus postplaque were unchanged or improved in more than half the eyes. Conclusions: Brachytherapy following OAC is effective, even in the presence of vitreous seeding; the majority of eyes maintained stable or improved retinal function following treatment, as assessed by ERG

  6. Sonic hedgehog initiates cochlear hair cell regeneration through downregulation of retinoblastoma protein

    International Nuclear Information System (INIS)

    Lu, Na; Chen, Yan; Wang, Zhengmin; Chen, Guoling; Lin, Qin; Chen, Zheng-Yi; Li, Huawei

    2013-01-01

    Highlights: ► Shh activation in neonatal cochleae enhances sensory cell proliferation. ► Proliferating supporting cells can transdifferentiate into hair cells. ► Shh promotes proliferation by transiently modulating pRb activity. ► Shh inhibits pRb by inhibiting transcription and increasing phosphorylation of pRb. -- Abstract: Cell cycle re-entry by cochlear supporting cells and/or hair cells is considered one of the best approaches for restoring hearing loss as a result of hair cell damage. To identify mechanisms that can be modulated to initiate cell cycle re-entry and hair cell regeneration, we studied the effect of activating the sonic hedgehog (Shh) pathway. We show that Shh signaling in postnatal rat cochleae damaged by neomycin leads to renewed proliferation of supporting cells and hair cells. Further, proliferating supporting cells are likely to transdifferentiate into hair cells. Shh treatment leads to inhibition of retinoblastoma protein (pRb) by increasing phosphorylated pRb and reducing retinoblastoma gene transcription. This results in upregulation of cyclins B1, D2, and D3, and CDK1. These results suggest that Shh signaling induces cell cycle re-entry in cochlear sensory epithelium and the production of new hair cells, in part by attenuating pRb function. This study provides an additional route to modulate pRb function with important implications in mammalian hair cell regeneration.

  7. Retinoblastoma protein expression is an independent predictor of both radiation response and survival in muscle invasive bladder cancer

    DEFF Research Database (Denmark)

    Agerbæk, Mads; Alsner, Jan; Marcussen, Niels

    2003-01-01

    The objective of the study was to investigate the predictive value of various clinical, biochemical, and histopathological parameters, with special emphasis on the expression of the retinoblastoma protein (pRB), on the radiation response in bladder cancer. In order to obtain a truly objective...

  8. Analysis of the RB1 gene in children with retinoblastoma having residential connections to West Cumbria, England

    Energy Technology Data Exchange (ETDEWEB)

    Cowell, J K [Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263 (United States); Morris, J A [Department of Pathology, Royal Lancaster Infirmary, Lancaster LA1 4RP (United Kingdom); Tawn, E J [Westlakes Research Institute, Moor Row, Cumbria CA24 3JY (United Kingdom)

    2005-03-01

    Six of eight cases of retinoblastoma previously identified as having a residential association with West Cumbria, England, in which the Sellafield nuclear installation is situated, were examined for the presence of a constitutional RB1 mutation. No mutations were detected, thus providing strong evidence against an environmental or occupational genotoxic effect causing germline mutations in the parents of these children. (note)

  9. Stage of presentation and visual outcome of patients screened for familial retinoblastoma: nationwide registration in the Netherlands

    NARCIS (Netherlands)

    Imhof, S. M.; Moll, A. C.; Schouten-van Meeteren, A. Y. N.

    2006-01-01

    In the Netherlands a comprehensive programme for screening just after birth for familial retinoblastoma is taking place. In this report the stage of the disease at the time of detection, by way of screening, and the long term visual outcome in these patients was evaluated. A nationwide,

  10. Activation of peroxisome proliferator-activated receptor gamma bypasses the function of the retinoblastoma protein in adipocyte differentiation

    DEFF Research Database (Denmark)

    Hansen, Jacob B.; Petersen, R K; Larsen, B M

    1999-01-01

    The retinoblastoma protein (pRB) is an important regulator of development, proliferation, and cellular differentiation. pRB was recently shown to play a pivotal role in adipocyte differentiation, to interact physically with adipogenic CCAAT/enhancer-binding proteins (C/EBPs), and to positively...

  11. External beam radiation for retinoblastoma: Results, patterns of failure, and a proposal for treatment guidelines

    International Nuclear Information System (INIS)

    Hernandez, J. Carlos; Brady, Luther W.; Shields, Jerry A.; Shields, Carol L.; Potter, Patrick de; Karlsson, Ulf L.; Markoe, Arnold M.; Amendola, Beatriz E.; Singh, Arun

    1996-01-01

    Purpose: To analyze treatment results and patterns of failure following external beam radiation for retinoblastoma and propose treatment guidelines according to specific clinical variables. Methods and Materials: We analyzed 27 patients (34 eyes) with retinoblastoma who received external beam radiation as initial treatment at Hahnemann University Hospital from October 1980 to December 1991 and have been followed for at least 1 year. Of the 34 eyes, 14 were Groups I-II (Reese-Ellsworth classification), 7 were Group III, and 13 were Groups IV-V. Doses ranged from 34.5-49.5 Gy (mean 44.3 Gy, median 45 Gy) in 1.5-2.0 Gy fractions generally delivered through anterior and lateral wedged pair fields. Results: At a mean follow up of 35.2 months (range 12-93 months), local tumor control was obtained in 44% (15 out of 34) of eyes with external beam radiation alone. Salvage therapy (plaque brachytherapy, cryotherapy, and/or photocoagulation) controlled an additional 10 eyes (29.5%), so that overall ocular survival has been 73.5%. Local tumor control with external beam radiotherapy alone was obtained in 78.5% (11 out of 14) of eyes in Groups I-II, but in only 20% (4 out of 20) of eyes in Groups III-V. A total of 67 existing tumors were identified prior to treatment in the 34 treated eyes and local control with external beam radiation alone was obtained in 87% (46 out of 53) of tumors measuring 15 mm or less and in 50% (7 out of 14) of tumors measuring more than 15 mm. When analyzing patterns of failure in the 19 eyes that relapsed, a total of 28 failure sites were identified and consisted of progression of vitreous seeds in seven instances (25% of failure sites) recurrences from previously existing tumors in 10 instances (36% of failure sites) and development of new tumors in previously uninvolved retina in 11 instances (39% of failure sites). Conclusions: 1) We find that external beam radiation to a dose of 45 Gy in fractions of 1.5 to 2.0 Gy provides adequate tumor control

  12. Responsabilidad internacional del individuo y responsabilidad internacional del Estado: Encuentros y desencuentros en torno a la figura de los `crímenes de derecho internacional´

    OpenAIRE

    Chinchón Álvarez, Javier

    2009-01-01

    Lo que nos va a ocupar en la presente contribución es la necesidad de una clara distinción entre lo propio de la responsabilidad internacional del Estado y lo relativo a la responsabilidad internacional del individuo; en un ámbito singular como es el de los conocidos como "crímenes de derecho internacional". Cuestión que, a nadie escapa, tiene unas implicaciones esenciales para no naufragar en los procelosos mares del Derecho internacional contemporáneo

  13. La Legitimación de Capitales y sus implicaciones económicas. Una aproximación a la conceptualización de este delito

    Directory of Open Access Journals (Sweden)

    Yosman Valderrama

    2015-09-01

    Full Text Available La legitimación de capitales es un fenómeno criminal de dimensiones internacionales, cristaliza el esfuerzo de la delincuencia organizada por darle apariencia legal a un dinero obtenido por actividades ilícitas. Con el propósito de conocer este fenómeno, la presente investigación tuvo como objetivo estudiar la legitimación de capitales y sus implicaciones económicas, tomando en consideración los constructos teóricos establecidos por los autores Cano y Lugo (2010, Perotti (2009, y Del Cid (2007. Metodológicamente, el estudio es una revisión documental y como instrumento de recolección de datos se acudió al uso del resumen analítico y el análisis crítico. Entre las consideraciones finales, este quebrantamiento normativo presenta efectos adversos sobre la economía de una nación, que pueden variar de acuerdo a las características particulares de cada país, dentro de las consecuencias más resaltantes destacan: incide en la volatilidad de la economía, repercute en el establecimiento de las políticas económicas, así como en la capacidad productiva nacional, promueve la competencia desleal, genera insatisfacción entre los sectores productivos, disminuye la credibilidad de las instituciones, desmejora la libre oferta y demanda de los productos de consumo masivo. No obstante, puede representar ficticiamente soluciones a problemas económicos, como la generación de empleo, el aumento en la aplicación de nueva tecnología en la producción agrícola, crecimiento de la construcción de infraestructuras, y hace visible un desarrollo económico del país que la sufre.

  14. Growth patterns of survivors of retinoblastoma treated with ophthalmic artery chemosurgery.

    Directory of Open Access Journals (Sweden)

    Sruti S Akella

    Full Text Available Although studies from pediatric cancers (largely acute lymphoblastic leukemia have shown that patients undergoing systemic chemotherapy may experience decreased growth velocity during the treatment phase, no such data exist for retinoblastoma patients treated with systemic chemotherapy or ophthalmic artery chemosurgery (OAC. The purpose of this study is to report growth patterns of our retinoblastoma (Rb population who were treated with OAC in a retrospective, single center (Memorial Sloan Kettering Cancer Center review of 341 patients treated between 2006 and 2016. Children who only received OAC were classified as naive; those who were treated initially with systemic chemotherapy and subsequently presented to our center for OAC were termed secondary; and a small group of patients who received single-agent systemic chemotherapy prior to OAC were labeled bridge. For all patients, height and weight were recorded at monthly intervals during OAC (short-term and then annually during a follow-up period (long-term up to 3 years after treatment. Excluded from this study were children who received external radiation therapy and those with genetic syndromes, which are independently associated with growth derangements. During OAC, there was no significant difference in growth velocity between the naïve and secondary groups. In either group, number of treatments also did not affect growth rate. Three years after the end of OAC, naïve patients were in the 68th percentile by height (95% CI 61.30, 74.63 compared to secondary patients in the 61st percentile (95% CI 51.1, 71.47. Both groups were in the same weight percentiles during the first two years of follow-up but at the three-year follow-up period, naïve patients were in the 63rd percentile (95% CI 57.4, 69.4 and secondary patients were in the 60th percentile (95% CI 50.4, 69.7. OAC for retinoblastoma does not appear to impact short-term growth velocity, weight gain during the treatment period or after

  15. Dosimetric intercomparison between protons and electrons therapies applied to retinoblastoma; Intercomparacao dosimetrica entre terapias de protons e eletrons aplicada ao retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Braga, Flavia Vieira

    2008-07-01

    In this work we propose a construction of a simple human eye model in order to simulate the dosimetric response for a treatment with protons and electrons in a retinoblastoma cancer. The computational tool used in this simulation was the Geant4 code, in the version 4.9.1, all these package are free and permit simulate the interaction of radiation with matter. In our simulation we use a box with 4 cm side, with water, for represent the human eye. The simulation was performed considering mono energetics beams of protons and electrons with energy range between 50 and 70 MeV for protons and 2 and 10 MeV for electrons. The simulation was based on the advanced hadron therapy example of the Geant 4 code. In these example the phantom is divided in voxels with 0.2 mm side and it is generated the energy deposited in each voxel. The simulation results show the energy deliver in each voxel, with these energie we can calculate the dose deposited in that region. We can see the dose profile of, proton and electron, and we can see in both cases that for protons the position of delivered dose is well know, that happen in the position where the proton stop, for electrons the energies is delivered along the way and pass the desired position for high dose deposition. (author)

  16. La importancia del <del consumidor de productos horticolas

    OpenAIRE

    Guerrero, Jose Felipe; Abad, Juan Carlos; Aguera, Emilia Del

    2010-01-01

    La percepcion sobre el pais de origen de un producto es uno de los principales determinates de la evaluacion y eleccion de dicho producto, sobre todo en los mercados foraneos. En la literatura de marketing existen multiples trabajos que han analizado este aspecto, si bien la amyor parte de ellos se han centrado en productos duraderos de alta implicacion. Este trabajo analiza la importancia que el atributo pais de origen tiene en el proceso de evaluacion del consumidor para el caso de la compr...

  17. Generación y recreación de contenidos digitales por los jóvenes: implicaciones para la alfabetización mediática

    OpenAIRE

    Soep, Elisabeth

    2012-01-01

    La era digital ha reconfigurado las relaciones entre productores y usuarios. Las acciones en red son potencialmente reinterpretadas por otros usuarios. La intención de los productores mediáticos adquiere su sentido en este contexto que denominamos «el más allá digital». En este artículo analizamos cómo ha influido este fenómeno en las implicaciones de los medios y los jóvenes. El estudio se lleva a cabo a través del análisis etnográfico de las actividades llevadas a cabo por un grupo de jóven...

  18. La suavidad de la carne: implicaciones físicas y bioquímicas asociadas al manejo y proceso agroindustrial

    Directory of Open Access Journals (Sweden)

    Alejandro Chac\\u00F3n

    2004-01-01

    Full Text Available La suavidad de la carne: implicaciones físicas y bioquímicas asociadas al manejo y proceso agroindustrial. Actualmente, el problema de la suavidad de la carne representa una gran preocupación entre los productores, dado que esta variable ha demostrado ser el principal criterio con base al cual los consumidores juzgan la calidad de la carne. El problema es especialmente importante si se considera que una de cada cuatro degustaciones de la carne resultan insatisfactorias para el consumidor. Este trabajo abordó los principales aspectos asociados con la suavidad de la carne tales como la estructura y composición de la carne, el fenómeno de la contracción muscular, los cambios bioquímicos post mortem como el rigor mortis y la maduración, y el efecto general debido a las operaciones del procesamiento industrial como la cocción y el congelamiento. Métodos generales para el mejoramiento de la suavidad son discutidos, así como la actividad bioquímica e importancia de las enzimas CALPAINAS (calcium ion dependent papain like cisteine proteases.

  19. ATRIBUTOS DEL PROBLEMA DINÁMICO DE CONTROL OPERACIONAL DE AGVS EN LA DISTRIBUCIÓN DE MATERIALES

    Directory of Open Access Journals (Sweden)

    Isidro Ramos Torres

    2016-06-01

    Full Text Available En este trabajo se estudian los atributos del problema dinámico del control operacional de AGVs. Se discuten las implicaciones del uso de la información on-line como el principal elemento del carácter dinámico de los problemas. Se utiliza la taxonomía de Psaraftis para identificar los atributos (evolución, calidad, disponibiliad, y procesamiento de la información utilizada. Se obtuvieron resultados parciales sobre las tendencias de los estudios dinámicos y sus características.

  20. Various ocular MR imaging in a mouse implanted with a new cell line of retinoblastoma and the correlation with the pathology: preliminary study

    International Nuclear Information System (INIS)

    Kim, Dong Hun; Kim, Il Joong; Yang, Jae Han; Byun, Joo Nam; Lee, Bong Jae; Kim, Jeong Hun; Yu, Young Suk

    2007-01-01

    We wanted to show various MR and correlated pathologic images of retinoblastoma in nude mouse with a new human retinoblastoma cell line (SNUOT-Rb1), which was inoculated into the intravitreous cavity. The established cell line was inoculated into the intravitreous cavity of 36 eyeballs of 18 mice and the transplanted retinoblastoma was examined for 3 months. The T1-weighted (T1WI), T2-weighted (T2WI), and contrast enhanced (Gd-DTPA) T1-weighted images were obtained with using a small loop coil. After scanning, the mice's eyeballs were extracted and the hematoxylin and eosin stained specimens were examined with a microscope. We compared the MR imagings with pathologic findings and evaluated the character of the tumors. The innoculated cells in the eyeballs of the mice grew into retinoblastoma (23/36, 64%). The eyeballs with retinoblastoma protruded externally and showed focal hemorrhage. Most tumors showed iso-signal intensity on TIWI (13/23, 57%), high signal intensity on T2WI (17/23, 74%), and good enhancement (21/23, 91%) with contrast. Almost all of the tumors (n = 21) were located in the retina and three extraretinal tumors were confirmed by pathology. Involvement of the optic nerve was suspected on MRI and this was confirmed by pathology in 6 cases and 5 cases, respectively. We could demonstrate various MR imagings of transplanted retinoblastoma by using the new tumor cell line in vivo

  1. Various ocular MR imaging in a mouse implanted with a new cell line of retinoblastoma and the correlation with the pathology: preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dong Hun; Kim, Il Joong; Yang, Jae Han; Byun, Joo Nam; Lee, Bong Jae [Chosun University, College of Medicine, Gwangju (Korea, Republic of); Kim, Jeong Hun; Yu, Young Suk [Seoul National University, College of Medicine, Seoul (Korea, Republic of)

    2007-05-15

    We wanted to show various MR and correlated pathologic images of retinoblastoma in nude mouse with a new human retinoblastoma cell line (SNUOT-Rb1), which was inoculated into the intravitreous cavity. The established cell line was inoculated into the intravitreous cavity of 36 eyeballs of 18 mice and the transplanted retinoblastoma was examined for 3 months. The T1-weighted (T1WI), T2-weighted (T2WI), and contrast enhanced (Gd-DTPA) T1-weighted images were obtained with using a small loop coil. After scanning, the mice's eyeballs were extracted and the hematoxylin and eosin stained specimens were examined with a microscope. We compared the MR imagings with pathologic findings and evaluated the character of the tumors. The innoculated cells in the eyeballs of the mice grew into retinoblastoma (23/36, 64%). The eyeballs with retinoblastoma protruded externally and showed focal hemorrhage. Most tumors showed iso-signal intensity on TIWI (13/23, 57%), high signal intensity on T2WI (17/23, 74%), and good enhancement (21/23, 91%) with contrast. Almost all of the tumors (n = 21) were located in the retina and three extraretinal tumors were confirmed by pathology. Involvement of the optic nerve was suspected on MRI and this was confirmed by pathology in 6 cases and 5 cases, respectively. We could demonstrate various MR imagings of transplanted retinoblastoma by using the new tumor cell line in vivo.

  2. Retinoblastoma protein co-purifies with proteasomal insulin-degrading enzyme: Implications for cell proliferation control

    Energy Technology Data Exchange (ETDEWEB)

    Radulescu, Razvan T., E-mail: ratura@gmx.net [Molecular Concepts Research (MCR), Muenster (Germany); Duckworth, William C. [Department of Medicine, Phoenix VA Health Care System, Phoenix, AZ (United States); Levy, Jennifer L. [Research Service, Phoenix VA Health Care System, Phoenix, AZ (United States); Fawcett, Janet, E-mail: janet.fawcett@va.gov [Research Service, Phoenix VA Health Care System, Phoenix, AZ (United States)

    2010-04-30

    Previous investigations on proteasomal preparations containing insulin-degrading enzyme (IDE; EC 3.4.24.56) have invariably yielded a co-purifying protein with a molecular weight of about 110 kDa. We have now found both in MCF-7 breast cancer and HepG2 hepatoma cells that this associated molecule is the retinoblastoma tumor suppressor protein (RB). Interestingly, the amount of RB in this protein complex seemed to be lower in HepG2 vs. MCF-7 cells, indicating a higher (cytoplasmic) protein turnover in the former vs. the latter cells. Moreover, immunofluorescence showed increased nuclear localization of RB in HepG2 vs. MCF-7 cells. Beyond these subtle differences between these distinct tumor cell types, our present study more generally suggests an interplay between RB and IDE within the proteasome that may have important growth-regulatory consequences.

  3. External radiotherapy for circumscribed choroidal haemangiomas using a modified retinoblastoma technique

    International Nuclear Information System (INIS)

    Eide, N.; Syrdalen, P.; Tausjoe, J.; Tveraa, K.

    1995-01-01

    This report describes two cases of circumscribed choroidal haemangiomas involving the fovea, complicated by serous retinal detachment. Laser photocoagulation, generally accepted as the treatment of choice for choroidal haemangioma, was considered either to be of no visual benefit or a risk for jeopardizing vision further due to the subfoveolar lesions. Fractionated radiotherapy using a lens-sparing, modified retinoblastoma technique, was given, using circular fields of 15 mm diameter. The dose was 24 Gy in 8 fractions. In both eyes the retina reattached completely. The visual acuity improved markedly in the first, and was restored to the prior level in the second. Normalization of a high intraocular pressure was also achieved in the second case. We believe this method to be a reasonable and effective therapy for some choroidal haemangiomas after careful individual consideration. (au) 17 refs

  4. Retinoblastoma and the Genetic Theory of Cancer: An Old Paradigm Trying to Survive to the Evidence

    International Nuclear Information System (INIS)

    Mastrangelo, D.; Lore, C.; Hadjistilianou, T.; De Francesco, S.

    2009-01-01

    Retinoblastoma (Rb) is considered to represent the prototype of cancer linked to the sequential loss or inactivation of both alleles of a so-called “tumor suppressor gene”, the Rb1 gene. The pathogenetic mechanism behind this tumor was first hypothesized by Knudson in 1971 and further confirmed by others who identified the Rb1 gene whose loss or inactivation was claimed to be responsible for the disease. However, after about four decades of continuous research in the field of molecular biology, the evidence behind the role of the Rb1 gene in Rb appears to be seriously flawed in the light of epidemiological, biological, and clinical evidences. This editorial summarizes the inconsistencies on this subject. Nevertheless, the molecular biology establishment still adheres to the biased view of the genetic origin of Rb and other cancers, and hardly any alternative explanations are taken into account.

  5. El lenguaje oficial en las instancias de participación local y algunas de sus implicaciones en la legitimación de la desigualdad política

    Directory of Open Access Journals (Sweden)

    César Augusto González Vélez

    2017-01-01

    En este panorama, la pregunta central es ¿qué implicaciones tiene la interiorización del lenguaje oficial en el mantenimiento de unas relaciones asimétricas entre los agentes de la participación política y las instituciones públicas?, este uno de los cuestionamientos que impulsó la investigación: “Organizaciones comunitarias e instancias de participación política de Engativá”, proyecto financiado en el 2014 por la III Convocatoria Interna de Investigación de la Universidad Minuto de Dios, sede principal y del cual se publicó el libro Los convidados de piedra de la participación local. En suma, la tesis que se defiende a lo largo del artículo es que si bien los agentes de la participación (especialmente los representantes populares conciben la interiorización del lenguaje oficial como una “ganancia”, en su proceso de reivindicación ante el Gobierno local, este mismo lenguaje limita la posibilidad instituyente de sus agencias y termina desvirtuando sus saberes, metodologías, intenciones y prácticas.

  6. Characterization and Expression Analysis of a Retinoblastoma-Related Gene from Chinese Wild Vitis pseudoreticulata.

    Science.gov (United States)

    Wen, Zhifeng; Gao, Min; Jiao, Chen; Wang, Qian; Xu, Hui; Walter, Monika; Xu, Weirong; Bassett, Carole; Wang, Xiping

    2012-01-01

    Retinoblastoma-related (RBR) genes, a conserved gene family in higher eukaryotes, play important roles in cell differentiation, development, and mammalian cell death; however, little is known of their function in plants. In this study, a RBR gene was isolated from the Chinese wild grape, Vitis pseudoreticulata W. T. Wang clone "Baihe-35-1", and designated as VpRBR . The cDNA sequence of VpRBR was 3,030 bp and contained an open reading frame of 3,024 bp. Conceptual translation of this gene indicated a composition of 1,007 amino acids with a predicted molecular mass of 117.3 kDa. The predicted protein showed a retinoblastoma-associated protein domain A from amino acid residues 416 to 579, and domain B from residues 726 to 855. The result of expression analysis indicated that VpRBR was expressed in tissues, leaves, stem, tendrils, flower, and grape skin at different expression levels. Further quantitative reverse transcription-PCR (qRT-PCR) data indicated that VpRBR levels were higher in Erysiphe necator-treated "Baihe-35-1" and "Baihe-13-1", two resistant clones of Chinese wild V. pseudoreticulata , than in E. necator-treated "Hunan-1", a susceptible clone of V. pseudoreticulata . Furthermore, the expression of VpRBR in response to salicylic acid (SA), methyl jasmonate (MeJA), and ethylene (Eth) in grape leaves was also investigated. Taken together, these data indicate that VpRBR may contribute to some aspect of powdery mildew resistance in grape.

  7. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.

    Science.gov (United States)

    Gray, Steven G; Iglesias, Antonio H; Lizcano, Fernando; Villanueva, Raul; Camelo, Sandra; Jingu, Hisaka; Teh, Bin T; Koibuchi, Noriyuki; Chin, William W; Kokkotou, Efi; Dangond, Fernando

    2005-08-05

    To effectively direct targeted repression, the class I histone deacetylases (HDACs) associate with many important regulatory proteins. In this paper we describe the molecular characterization of a member of the Jumonji domain 2 (JMJD2) family of proteins, and demonstrate its binding to both class I HDACs and the retinoblastoma protein (pRb). JMJD2 proteins are characterized by the presence of two leukemia-associated protein/plant homeodomain (LAP/PHD) zinc fingers, one JmjN, one JmjC (containing an internal retinoblastoma-binding protein 2 (RBBP2)-like sequence), and two Tudor domains. The first member of this group, JMJD2A, is widely expressed in human tissues and cell lines, and high endogenous expression of JMJD2A mRNA was found in several cell types, including human T-cell lymphotropic virus 1 (HTLV-1)-infected cell lines. JMJD2A and JMJD2B exhibit cell type-specific responses to the HDAC inhibitor trichostatin A. We show that the JMJD2A protein associates in vivo with pRb and class I HDACs, and mediates repression of E2F-regulated promoters. In HTLV-1 virus-infected cells, we find that JMJD2A binds to the viral Tax protein. Antibodies to JMJD2A recognize the native protein but also a half-sized protein fragment, the latter up-regulated in THP-1 cells during the G(2)/M phase of the cell cycle. The ability of JMJD2A to associate with pRb and HDACs and potentiate pRb-mediated repression of E2F-regulated promoters implies an important role for this protein in cell proliferation and oncogenesis.

  8. An international survey of classification and treatment choices for group D retinoblastoma

    Directory of Open Access Journals (Sweden)

    Jasmine H Francis

    2017-06-01

    Full Text Available AIM: To determine which IIRC scheme was used by retinoblastoma centers worldwide and the percentage of D eyes treated primarily with enucleation versus globe salvaging therapies as well as to correlate trends in treatment choice to IIRC version used and geographic region. METHODS: An anonymized electronic survey was offered to 115 physicians at 39 retinoblastoma centers worldwide asking about IIRC classification schemes and treatment patterns used between 2008 and 2012. Participants were asked to record which version of the IIRC was used for classification, how many group D eyes were diagnosed, and how many eyes were treated with enucleation versus globe salvaging therapies. Averages of eyes per treatment modality were calculated and stratified by both IIRC version and geographic region. Statistical significance was determined by Chi-square, ANOVA and Kruskal-Wallis tests using Prism. RESULTS: The survey was completed by 29% of physicians invited to participate. Totally 1807 D eyes were diagnosed. Regarding IIRC system, 27% of centers used the Children’s Hospital of Los Angeles (CHLA version, 33% used the Children’s Oncology Group (COG version, 23% used the Philadelphia version, and 17% were unsure. The rate for primary enucleation varied between 0 and 100% and the mean was 29%. By IIRC version, primary enucleation rates were: Philadelphia, 8%; COG, 34%; and CHLA, 37%. By geographic region, primary enucleation rates were: Latin America, 57%; Asia, 40%; Europe, 36%; Africa, 10%, US, 8%; and Middle East, 8%. However, systemic chemoreduction was used more often than enucleation in all regions except Latin America with a mean of 57% per center (P<0.0001. CONCLUSION: Worldwide there is no consensus on which IIRC version is used, systemic chemoreduction was the most frequently used initial treatment during the study period followed by enucleation and primary treatment modality, especially enucleation, varied greatly with regards to IIRC version

  9. Glycodendrimeric phenylporphyrins as new candidates for retinoblastoma PDT: blood carriers and photodynamic activity in cells.

    Science.gov (United States)

    Wang, Ze-Jian; Chauvin, Benoît; Maillard, Philippe; Hammerer, Fabien; Carez, Danièle; Croisy, Alain; Sandré, Catherine; Chollet-Martin, Sylvie; Prognon, Patrice; Paul, Jean-Louis; Blais, Jocelyne; Kasselouri, Athena

    2012-10-03

    Photodynamic therapy (PDT) has recently been proposed as a possible indication in the conservative treatment of hereditary retinoblastoma. In order to create photosensitizers with enhanced targeting ability toward retinoblastoma cells, meso-tetraphenylporphyrins bearing one glycodendrimeric moiety have been synthesized. The binding properties to plasma proteins and photodynamic activity of two monodendrimeric porphyrins bearing three mannose units via monoethylene glycol (1) or diethylene glycol (2) linkers have been compared to that of the non-dendrimeric tri-substituted derivative [TPP(p-Deg-O-α-ManOH)(3)]. The dendrimeric structure was found to highly increase the binding affinity to plasma proteins and to modify to some extent plasma distribution. HDL and to a lesser extent LDL have been shown to be the main carriers of dendrimeric and non-dendrimeric compounds. The phototoxicity observed for the two glycodendrimers (1) and (2) (LD(50)=0.5 μM) in Y79 cells is of the same order of magnitude that for TPP(p-Deg-O-α-ManOH)(3) (LD(50)=0.7 μM), with a similar cellular uptake level for (1) and a lower for (2). A serum content increase from 2% to 20% (v/v) in the incubation medium was found to inhibit both cellular uptake and photoactivity of dendrimeric derivatives, whereas those of TPP(p-Deg-O-α-ManOH)(3) remained little affected. Specificities of glycodendrimeric porphyrins, combining a lower cellular uptake together with a higher affinity toward plasma proteins, make these derivatives possible candidates for a vascular targeting PDT. Copyright © 2012 Elsevier B.V. All rights reserved.

  10. Origen, dispersión y diversidad del chirimoyo (Annona cherimola Mill.) en el continente americano

    OpenAIRE

    Larrañaga González, Nerea

    2017-01-01

    En este trabajo se ha profundizado en las razones que pueden explicar la distribución actual de la diversidad genética del chirimoyo (Annona cherimola Mill.), una especie frutal adaptada a climas subtropicales, con claras implicaciones para su uso y conservación. Gracias a un estudio de código de barras, se pudo comprobar el poder de discriminación del gen cloroplastídico maturasa K (matK) entre las especies con mayor importancia agronómica del género. Además, sobre los polimorfismos de nucle...

  11. Apuntes en torno al TLC Centroamérica /Estados Unidos y sus implicaciones para la educación superior

    Directory of Open Access Journals (Sweden)

    Muñoz Varela, Luis

    2005-03-01

    Full Text Available El presente artículo tiene como propósito realizar una breve aproximación analítica a los aspectos que, en el marco de la propuesta de Tratado de Libre Comercio entre Centroamérica y Estados Unidos, conciernen o implican a la educación superior y, en especial, a la educación superior pública. El artículo aborda dos ejes de análisis. El primero de ellos, está referido específicamente a los lineamientos y estipulaciones que involucra el texto del TLC Centroamérica/Estados Unidos, en lo relativo a las implicaciones que derivan de esa propuesta para las instituciones de educación superior y, en particular, para la educación superior pública. El segundo eje, por su parte, consiste en una breve revisión de trabajos elaborados por especialistas en torno a los alcances que, en su caso, presentan para la educación superior algunas de las estipulaciones contenidas en el Acuerdo General sobre Comercio de Servicios (AGCS, de la Organización Mundial del Comercio. This article intends to make a brief analysis about the repercussions of the Free Trade Agreement between Central America and The United States (CAFTA on the aspects concerning to the Higher education; especially, public higher education. There are two analysis approaches in this article. The first one deals specifically with the tendencies and regulations of the CAFTA in reference to its proposal to the high educational field. The second approach refers to a brief literary review about some specialists’ works related to the consequences to the higher education of some regulations contained in the Service Trade General Agreement by the World Commerce Organization.

  12. Reflexiones sobre la guerra y sus implicaciones en la salud humana

    Directory of Open Access Journals (Sweden)

    . Luis Angel Pérez Flerima

    2017-11-01

    Full Text Available El presente trabajo está dirigido a la reflexión de un fenómeno complejo y dramático para la vida de millones de seres humanos en el mundo como es la guerra, que con el avance científico- tecnológico ha hecho más terrible su impacto con la correspondiente secuela para la humanidad. Este artículo expresa sucintamente los orígenes de la guerra, el papel que los Estados Unidos desempeñan en los diferentes conflictos regionales como principal potencia imperialista. Por ello se valora el fenómeno de la guerra y sus implicaciones en la salud humana.

  13. Diffuse chorioretinal atrophy after a single standard low- dose intravitreal melphalan injection in a child with retinoblastoma: a case report.

    Science.gov (United States)

    Chao, An- Ning; Kao, Ling-Yuh; Liu, Laura; Wang, Nan-Kai

    2016-03-15

    Controlling retinoblastoma with seeding is challenging despite advances in treatment modalities. Intravitreal melphalan is an alternative to external beam radiation or enucleation for recurrent or refractory vitreous seeds. Significant ocular side effects following intravitreal melphalan injections are uncommon. Complications have been reported in eyes receiving higher concentrations of melphalan and repetitive injections. We report a case in which diffuse chorioretinal atrophy was developed at the injection site after a single, standard low-dose intravitreal melphalan injection. A 12-month-old female child without a family history of retinoblastoma presented with unilateral group C retinoblastoma in her right eye. A solitary tumour with retinal breaks on the tumour surface, and vitreous seeds overlying the tumour were observed at the 8 o'clock position of the retina. After two cycles of intra-arterial chemotherapy with melphalan, the main tumour displayed significant regression, but the vitreous seeds overlying the main tumour were still active. Because of the persistence of vitreous seeds and the inadequate response to intra-arterial melphalan treatment, intravitreal melphalan (8 μg in 0.05 mL) was injected using a 32-gauge needle 2.5 mm from the 5 o'clock position of the limbus, the meridian opposite to the vitreous seeds. After 1 month, the retina around the injection site demonstrated diffuse retinal pigment epithelium alterations with dense hard exudates. Although the main retinal mass, and vitreous seeds resolved, the hard exudates persisted for more than 2 years after the single low-dose melphalan injection. Intravitreal melphalan injections should be cautiously used for eyes with refractory seeds, particularly when multiple injections are required to control retinoblastoma seeds. Dose- related retinal toxicity could occur in pre-treated eyes even when a relatively low standard dose is used. Such patients should be followed up closely to monitor the

  14. Experimental Model to Study the Role of Retinoblastoma Gene Product (pRb) for Determination of Adipocyte Differentiation.

    Science.gov (United States)

    Popov, B V; Shilo, P S; Zhidkova, O V; Zaichik, A M; Petrov, N S

    2015-06-01

    Using stable constitutive expression of retinoblastoma gene product (pRb) in polypotent mesenchymal 10T1/2 cells we obtained stable cell lines hyperexpressing functionally active or inactive mutant pRb. The cells producing active exogenous pRb demonstrated high sensitivity to adipocyte differentiation inductors, whereas production of inactive form of the exogenous protein suppressed adipocyte differentiation. The obtained lines can serve as the experimental model for studying the role of pRb in determination of adipocyte differentiation.

  15. Cdh11 Acts as a Tumor Suppressor in a Murine Retinoblastoma Model by Facilitating Tumor Cell Death

    Science.gov (United States)

    Marchong, Mellone N.; Yurkowski, Christine; Ma, Clement; Spencer, Clarellen; Pajovic, Sanja; Gallie, Brenda L.

    2010-01-01

    CDH11 gene copy number and expression are frequently lost in human retinoblastomas and in retinoblastomas arising in TAg-RB mice. To determine the effect of Cdh11 loss in tumorigenesis, we crossed Cdh11 null mice with TAg-RB mice. Loss of Cdh11 had no gross morphological effect on the developing retina of Cdh11 knockout mice, but led to larger retinal volumes in mice crossed with TAg-RB mice (p = 0.01). Mice null for Cdh11 presented with fewer TAg-positive cells at postnatal day 8 (PND8) (p = 0.01) and had fewer multifocal tumors at PND28 (p = 0.016), compared to mice with normal Cdh11 alleles. However, tumor growth was faster in Cdh11-null mice between PND8 and PND84 (p = 0.003). In tumors of Cdh11-null mice, cell death was decreased 5- to 10-fold (p<0.03 for all markers), while proliferation in vivo remained unaffected (p = 0.121). Activated caspase-3 was significantly decreased and β-catenin expression increased in Cdh11 knockdown experiments in vitro. These data suggest that Cdh11 displays tumor suppressor properties in vivo and in vitro in murine retinoblastoma through promotion of cell death. PMID:20421947

  16. Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death.

    Directory of Open Access Journals (Sweden)

    Mellone N Marchong

    2010-04-01

    Full Text Available CDH11 gene copy number and expression are frequently lost in human retinoblastomas and in retinoblastomas arising in TAg-RB mice. To determine the effect of Cdh11 loss in tumorigenesis, we crossed Cdh11 null mice with TAg-RB mice. Loss of Cdh11 had no gross morphological effect on the developing retina of Cdh11 knockout mice, but led to larger retinal volumes in mice crossed with TAg-RB mice (p = 0.01. Mice null for Cdh11 presented with fewer TAg-positive cells at postnatal day 8 (PND8 (p = 0.01 and had fewer multifocal tumors at PND28 (p = 0.016, compared to mice with normal Cdh11 alleles. However, tumor growth was faster in Cdh11-null mice between PND8 and PND84 (p = 0.003. In tumors of Cdh11-null mice, cell death was decreased 5- to 10-fold (p<0.03 for all markers, while proliferation in vivo remained unaffected (p = 0.121. Activated caspase-3 was significantly decreased and beta-catenin expression increased in Cdh11 knockdown experiments in vitro. These data suggest that Cdh11 displays tumor suppressor properties in vivo and in vitro in murine retinoblastoma through promotion of cell death.

  17. El desarrollo de la identidad profesional del profesorado: el caso del especialista de música

    Directory of Open Access Journals (Sweden)

    José Luis Aróstegui Plaza

    2013-01-01

    Full Text Available En este artículo me propongo hacer una revisión del concepto de identidad social y de sus implicaciones para la formación del profesorado de música. Para ello hablaré, en primer lugar, de los conceptos de «identidad social» y de su variante, las «identidades sonoras», que forma parte de él. En segundo, se verá su implicación para la formación de la «identidad profesional» del profesorado de música. Finalmente, haré una reflexión de las consecuencias que pueden sacarse para toda la formación del profesorado. El caso del profesorado de música puede ser ilustrativo de cómo una concentración en contenidos o en competencias, las mismas para todo el mundo, nos lleva a un modelo de profesorado muy distinto a otro centrado en la comprensión del significado de las interacciones que se producen en el aula. Me propongo, pues, ofrecer datos que puedan ser interesantes para quienes estén interesados en la formación del profesorado de música, al tiempo que se aborda una cuestión relevante para la formación del profesorado en general.

  18. Construction and transformation of social representations of AIDS and implications for health care Construcción y transformación de las representaciones sociales del sida e implicaciones para los cuidados en salud Construção e transformação das representações sociais da aids e implicações para os cuidados de saúde

    Directory of Open Access Journals (Sweden)

    Denize Cristina de Oliveira

    2013-02-01

    Full Text Available OBJECTIVES: to analyze the process of the constitution and evolution of social representations and practices referent to aids, based on studies carried out in the last eleven years among health professionals. METHOD: a comparison of representational structures of aids in different decades was undertaken, accompanied by a study of the silent zone, involving health professionals. Data collection and analysis included techniques of free association, structural analysis, and study of the silent zone. RESULTS: the existence of a process of change was observed in the social representations of aids, with the introduction of the possibility of co-existence with the disease and the reduction of the importance of death. CONCLUSIONS: this process is presented as the result of a complex movement of symbolic constructions arising from human interactions, contributing to knowledge of ways of thinking associated with the syndrome and to professional practices in healthcare.OBJETIVOS: Discutir la constitución y evolución de las representaciones y de las prácticas sociales relativas al sida, a partir de los estudios desarrollados en los últimos once años, entre profesionales de la salud. MÉTODOS: Fue realizada una comparación de las estructuras representacionales del sida en diferentes décadas, acompañada de un estudio de zona muda, envolviendo profesionales de la salud. La recolecta y el análisis de los datos abarcó las técnicas de evocación libre, análisis estructural y estudio de zona muda. RESULTADOS: Se observó la existencia de un proceso de cambio en las representaciones sociales del sida, con la introducción de la posibilidad de convivencia con la enfermedad y la disminución de la importancia de la muerte. CONCLUSIONES: Este proceso se muestra como resultado de un proceso complejo de construcciones simbólicas que surgen de las interacciones humanas, lo que contribuye al conocimiento de las formas de pensamiento asociadas con el s

  19. IMPLICACIONES BIOÉTICAS Y BIOJURÍDICAS DE LA OBJECIÓN DE CONCIENCIA INSTITUCIONAL CON RELACIÓN AL ABORTO EN EL ORDENAMIENTO JURÍDICO COLOMBIANO

    Directory of Open Access Journals (Sweden)

    Amparo de Jesús Zárate Cuello

    2011-01-01

    Full Text Available El comienzo de la vida humana se encuentra en vilo en Colombia, ante la ratificación del Protocolo Facultativo sobre la eliminación de todas las formas de discriminación contra la mujer, adoptada por la Asamblea General de las Naciones Unidas de 1999, ratificada en el año de 2005. El tema se desarrolla en dos Sentencias, la primera, C-355 de 2006 despenaliza el aborto en tres situaciones excepcionales: Violación, enfermedad de la madre y malformación del feto. La segunda, T-388 de 2009 abarca la objeción de conciencia, que solamente es reconocida a las personas naturales; afirmando el máximo Tribunal Constitucional que no es un derecho del cual sean titulares las personas jurídicas o el Estado, limitando a las clínicas, hospitales y centros de salud que presenten objeción de conciencia para la no realización de la práctica del aborto. El no cumplimiento de esta declaración ha producido sanciones a las instituciones sanitarias privadas por el no acatamiento de los efectos erga ommes de las sentencias proferidas por la Corte Constitucional; estas instituciones reclaman objeción de conciencia institucional por su ideario y creencias religiosas. Estos criterios tienen implicaciones bioéticas y biojurídicas frente a la interpretación pluralista de orden filosófico, religioso y jurídico del artículo 18 de la Carta Política; el cual, garantiza la libertad de conciencia en nuestro Estado Social de Derecho y, es el legislador quien debe reasumir su competencia a través del bioderecho.

  20. Implicaciones de la zona Ossa-Morena y dominios equivalentes en el modelo geodinámico de la Cadena Hercinica europea

    Directory of Open Access Journals (Sweden)

    Castro, A.

    1987-08-01

    Full Text Available The Ossa-Morena zone (OMZ has some peculiar features clearly different from those of the other inner domains in the Iberic Hercynian chain. It is a continental domain (microcontinent ? attached, from Lower Paleozoic times, to the continental crust of the Central Iberian zone (CIZ. During the Hercynian collision (Upper Paleozoic the OMZ behaved in a way different form that of adjacent areas (CIZ due to the peculiar features (Iess thicknees and pre-Hercynian evolution (Ordovician rifting. The OMZ, and their equivalent domains in the Iberian peninsula as well as in European chain, can have strong implications on the evolution of the Hercynian orogene. Part of the OMZ crust (and equivalent domains, together with the oceanic crust developed within it during the Ordovician rifting, was obduced over the inner domains (CIZ in areas of frontal collision (e.g. NW Iberian peninsula and French Massif Central and strongly stretched in areas of oblique collision (e.g. OMZ of SW Iberian peninsula and North Armorican domains.La zona Ossa-Morena (ZOM del hercínico peninsular posee unas características peculiares que la diferencian netamente de los otros dominios internos de la Cadena. Se trata de un dominio cortical (microcontinente ? adosado a la corteza de la Zona Centro-Ibérica (ZCI desde el Paleozoico Inferior. Durante la colisión continental hercínica (Palezoico Superior la ZOM responde de diferente forma que las zonas adyacentes (ZCI debido a su diferente constitución (menor espesor y peculiar evolución prehercínica (rifting ordovícico. Esta zona y sus equivalentes en otros dominios del hercínico peninsular y europeo, tienen fuertes implicaciones en el desarrollo del orógeno hercínico. Parte de la corteza continental de la ZOM fue, junto con la corteza oceánica desarrollada localmente en su interior durante el rifting ordovícido, obducida sobre los dominios internos (ZCI en zonas de colisión frontal (e.g. NW peninsular y Macizo C

  1. Esteres metílicos de ácidos grasos como carburantes. Implicaciones económicas, ecológicas y energéticas

    Directory of Open Access Journals (Sweden)

    Gómez Herrera, Carlos

    1995-04-01

    Full Text Available Changes in the "Common Agricultural Policy" of the European Union have increased the rapeseed crops on "set-aside" lands remarkably. Rapeseed oils are transesterified with methanol to obtain fatty acid methyl esters. Blends of these esters with diesel oil are sold in petrol stations in different european countries like any other fuel.
    This informative article starts by reviewing basic characteristics of diesel fuel, and continues with an analysis of physical properties, chemical composition and present specifications for the rapeseed methyl esters. Subsequently several implications derived from the industrial development of this biofuel are discussed. These implications are economic (production, consumption, prices, subventions, tax exemptions, ecological (nearly zero emissions for whole cycle of carbon dioxide, other exhaust emissions from combustion, ecobalances, and energetic (complete evaluation of energy expenditure for production, energetic ratios.

    Los cambios en la "Common Agricultural Policy" de la Unión Europea han incrementado notablemente los cultivos de colza en los terrenos "setaside". El aceite de colza se transesterifica con metanol para obtener esteres metílicos de ácidos grasos del aceite de sus semillas. Mezclas de estos metilésteres con gasóleo se venden en gasolineras de diferentes países europeos como cualquier otro carburante.
    Este artículo de información comienza por una revisión de características básicas del gasóleo, seguida por un análisis de las propiedades físicas, la composición química y las especificaciones actuales de los metilésteres de colza. A continuación se discuten diversas implicaciones derivadas del desarrollo industrial de este biocombustible. Las mismas son económicas (producción, consumo, precios, subvenciones, exención de Impuestos, ecológicas (emisiones casi nulas para el ciclo completo del dióxido de carbono, otras emisiones procedentes de la combusti

  2. Accesibilidad universal: sentido normativo e implicaciones en la educación y la práctica profesional

    Directory of Open Access Journals (Sweden)

    Manuel Aparicio Payá

    2017-06-01

    Full Text Available En la Convención Internacional sobre los Derechos de las Personas con Discapacidad, aprobada por la ONU en 2006, se incluye el derecho a la accesibilidad universal y el diseño para todas las personas. En este trabajo nos ocupamos, en primer lugar, de clarificar el sentido normativo que tiene este derecho. Posteriormente, analizamos sus implicaciones en el ámbito de la ética de las profesiones, mostrando la responsabilidad de los profesionales en el diseño de un espacio social diverso y común. Finalmente, analizamos las implicaciones en la educación universitaria que ha de preparar a los profesionales para realizar tal diseño.

  3. Gestión empresarial orientada al valor del cliente como fuente de ventaja competitiva. Propuesta de un modelo explicativo

    Directory of Open Access Journals (Sweden)

    LESLIER VALENZUELA

    2008-01-01

    fi ables que han sido aplicados al sector turístico, específi camente, a las agencias de viajes en España. Los resultados revelan que existe una relación positiva y signifi cativa entre el grado de orientación al valor del cliente y las mejores decisiones estratégicas de marketing. Finalmente, el estudio presenta las conclusiones e implicaciones que estos resultados pudieran tener para la gestión empresarial.

  4. Proton and electron deep dose profiles for retinoblastoma based on GEANT 4 code

    International Nuclear Information System (INIS)

    Braga, Flavia V.; Campos, Tarcisio P.R. de; Ribeiro, Kilder L.

    2009-01-01

    Herein, the dosimetry responses to a retinoblastoma proton and electron radiation therapy were investigated. The computational tool applied to this simulation was the Geant4 code, version 4.9.1. The code allows simulating the charge particle interaction with eyeball tissue. In the present simulation, a box of 4 cm side water filled had represented the human eye. The simulation was performed considering mono energetic beams of protons and electrons with spectra of 57 to 70 MeV for protons and 2 to 8 MeV for electrons. The simulation was guide by the advanced hadron therapy example distributed with the Geant4 code. The phantom was divided in voxels with 0.2 mm side. The energy deposited in each voxel was evaluated taken the direct beam at one face. The simulation results show the delivery energy and therefore the dose deposited in each voxel. The deep dose profiles to proton and electron were plotted. The well known Bragg peak was reproduced for protons. The maximum delivered dose defined the position at the proton stopped. However, to electrons, the absorbed energies were delivered along its path producing a more continuous distribution following the water depth, but also being stopped in the end of its path. (author)

  5. PCR detection of retinoblastoma gene deletions in radiation-induced mouse lung adenocarcinomas

    International Nuclear Information System (INIS)

    Churchill, M.E.; Gemmell, M.A.; Woloschak, G.E.

    1994-01-01

    From 1971--1986, Argonne National Laboratory conducted a series of large-scale studies of tumor incidence in 40,000 BCF 1 mice irradiated with 60 Co γ-rays or JANUS fission-spectrum neutrons. Polymerase chain reaction (PCR) technique was used to detect deletions in the mouse retinoblastoma (mRb) gene. Six mRb gene exon fragments were amplified in a 40-cycle, 3-temperature PCR protocol. Absence of any of these fragments on a Southern blot indicated a deletion of that portion of the mRb gene. Tumors chosen for analysis were lung adenocarcinomas that were judged to be the cause of death in post-mortem analyses. Spontaneous tumors as well as those from irradiated mice were analyzed for mRb deletions. In all normal mouse tissues studies all six mRb exon fragments were present on Southern blots. Tumors in six neutron-irradiated mice also had no mRb deletions. However, 1 of 6 tumors from γ-irradiated mice and 6 of 18 spontaneous tumors from unirradiated mice showed a deletion in one or both mRb alleles. All deletions detected were in the 5' region of the mRb gene

  6. MiR-200c suppresses the migration of retinoblastoma cells by reversing epithelial mesenchymal transition

    Directory of Open Access Journals (Sweden)

    Xiao-Lei Shao

    2017-08-01

    Full Text Available AIM: To analyze the relationship between clinical features and epithelial mesenchymal transition (EMT in retinoblastoma (RB, further to investigate whether miR-200c regulates the EMT and migration of RB cells. METHODS: Expression of EMT-related markers and tumor-related factors were detected by immuno-histochemistry analysis in RB tissue from 29 cases. Correlations between their expression and clinical characteristics were analyzed. The regulation effects of miR-200c on EMT-related markers, tumor-related factors were observed in mRNA level and protein level by real-time polymerase chain reaction (PCR and Western blot, respectively, in Y79 and Weri-rb1 cells. Its effects on migration force of these RB cell lines were also detected with Transwell test. RESULTS: Lower expression of E-cadherin was present in the cases with malignant prognosis. MiR-200c promoted the expression of E-cadherin and decreased the expression of Vimentin and N-cadherin in Y79 and Weri-rb1 cells. Migration force of RB cells could be inhibited by miR-200c. CONCLUSION: EMT might be associated with bad prognosis in RB. MiR-200c suppresses the migration of retinoblastomatous cells by reverse EMT.

  7. RETINOBLASTOMA IN INDIA: Clinical Presentation and Outcome in 1,457 Patients (2,074 Eyes).

    Science.gov (United States)

    Kaliki, Swathi; Patel, Anamika; Iram, Sadiya; Ramappa, George; Mohamed, Ashik; Palkonda, Vijay A R

    2017-11-23

    To study the clinical presentation, treatment, and outcome of patients with retinoblastoma (RB) in India. Retrospective study of 1,457 patients with RB (2,074 eyes). The mean age at presentation of RB was 29 months (median, 24 months; range, presentation of RB in 57% (n = 834) and bilateral in 43% (n = 623). Familial RB was present in 4% (n = 55). The most common presenting complaints included leukocoria (n = 1,100; 75%), proptosis (n = 91; 6%), strabismus (n = 77; 5%), and red eye (n = 68; 5%). Most (n = 1,889; 91%) tumors were intraocular in location, and 185 (n = 185; 9%) had extraocular tumor extension at presentation. The most common modalities of primary treatment-included systemic chemotherapy (n = 1,171; 60%) and enucleation (n = 674; 35%). At a mean follow-up period of 44 months (median, 30 months; range, 3-234 months), 92% (n = 1,206) were alive, and 108 (8%) patients died because of RB. Based on Kaplan-Meier analysis, the survival at 1, 3, 5, and 10 years was 94%, 91%, 90%, and 89%, respectively. The most common presenting signs of RB in Asian Indian population are leukocoria and proptosis. With appropriate treatment, the survival rate is favorable at 92%.

  8. Interaction of fish aryl hydrocarbon receptor paralogs (AHR1 and AHR2) with the retinoblastoma protein

    Energy Technology Data Exchange (ETDEWEB)

    Merson, Rebeka R., E-mail: rmerson@ric.edu [Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543 (United States); Biology Department, Rhode Island College, 500 Mt. Pleasant Ave., Providence, RI 02908 (United States); Karchner, Sibel I.; Hahn, Mark E. [Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543 (United States)

    2009-08-13

    The aryl hydrocarbon receptor (AHR) mediates the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. In some mammalian cell lines, TCDD induces G1 cell cycle arrest, which depends on an interaction between the AHR and the retinoblastoma tumor suppressor (RB). Mammals possess one AHR, whereas fishes possess two or more AHR paralogs that differ in the domains important for AHR-RB interactions in mammals. To test the hypothesis that fish AHR paralogs differ in their ability to interact with RB, we cloned RB cDNA from Atlantic killifish, Fundulus heteroclitus, and studied the interactions of killifish RB protein with killifish AHR1 and AHR2. In coimmunoprecipitation experiments, in vitro-expressed killifish RB coprecipitated with both AHR1 and AHR2. Consistent with these results, both killifish AHR1 and AHR2 interacted with RB in mammalian two-hybrid assays. These results suggest that both fish AHR1 and AHR2 paralogs may have the potential to influence cell proliferation through interactions with RB.

  9. Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining

    Directory of Open Access Journals (Sweden)

    Rebecca Cook

    2015-03-01

    Full Text Available Deficiencies in DNA double-strand break (DSB repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1 is required for DNA DSB repair by canonical non-homologous end-joining (cNHEJ. Support of cNHEJ involves a mechanism independent of RB1’s cell-cycle function and depends on its amino terminal domain with which it binds to NHEJ components XRCC5 and XRCC6. Cells with engineered loss of RB family function as well as cancer-derived cells with mutational RB1 loss show substantially reduced levels of cNHEJ. RB1 variants disabled for the interaction with XRCC5 and XRCC6, including a cancer-associated variant, are unable to support cNHEJ despite being able to confer cell-cycle control. Our data identify RB1 loss as a candidate driver of structural genomic instability and a causative factor for cancer somatic heterogeneity and evolution.

  10. Expressions of matrix metalloproteinase-2 and extracellular matrix metalloproteinase inducer in retinoblastoma

    Directory of Open Access Journals (Sweden)

    Yu-Hong Cheng

    2015-07-01

    Full Text Available AIM: To investigate expressions of matrix metalloproteinase-2(MMP-2and extracellular matrix metalloproteinase inducer(EMMPRINin retinoblastoma(Rband the relationships between MMP-2, EMMPRIN and tumor development.METHODS:Immunohistochemical technique was used to detect expressions of MMP-2 and EMMPRIN in 39 cases of paraffin embedded Rb samples. Quantitative analysis of expressions of MMP-2 and EMMPRIN were assessed by measuring the mean gray scale of Rb tissue with LEICA IM50 Color Pathologic Analysis System. The differences of expressions of MMP-2 and EMMPRIN in each clinical and pathological stage were statistically analyzed, and the same step was also undertaken to study the relationship between Rb with MMP-2 positive expression and that with EMMPRIN positive expression.RESULTS: The positive expression rate of MMP-2 was 90%(Gray value: 109.64±14.52; 35/39, and that of EMMPRIN was 85%(Gray value: 108.01±13.60; 33/39. The expressions of MMP-2 and EMMPRIN were significantly higher in tumors of glaucomatous stage(Gray value: 108.21±11.47 and 107.56±14.32than those in intraocular stage(Gray value: 121.13±11.32 and 119.34±12.66; PPPPPPCONCLUSION: The positive expression levels of MMP-2 and EMMPRIN may correlate with tumor infiltration and metastasis.

  11. Proton and electron deep dose profiles for retinoblastoma based on GEANT 4 code

    Energy Technology Data Exchange (ETDEWEB)

    Braga, Flavia V., E-mail: flaviafisica@gmail.co [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Programa de Pos-graduacao em Ciencias e Tecnicas Nucleares; Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Campos, Tarcisio P.R. de [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Programa de Pos-graduacao em Ciencias e Tecnicas Nucleares; Ribeiro, Kilder L., E-mail: kilderlr@gmail.co [Universidade Estadual de Feira de Santana (UEFS), BA (Brazil). Dept. de Fisica

    2009-07-01

    Herein, the dosimetry responses to a retinoblastoma proton and electron radiation therapy were investigated. The computational tool applied to this simulation was the Geant4 code, version 4.9.1. The code allows simulating the charge particle interaction with eyeball tissue. In the present simulation, a box of 4 cm side water filled had represented the human eye. The simulation was performed considering mono energetic beams of protons and electrons with spectra of 57 to 70 MeV for protons and 2 to 8 MeV for electrons. The simulation was guide by the advanced hadron therapy example distributed with the Geant4 code. The phantom was divided in voxels with 0.2 mm side. The energy deposited in each voxel was evaluated taken the direct beam at one face. The simulation results show the delivery energy and therefore the dose deposited in each voxel. The deep dose profiles to proton and electron were plotted. The well known Bragg peak was reproduced for protons. The maximum delivered dose defined the position at the proton stopped. However, to electrons, the absorbed energies were delivered along its path producing a more continuous distribution following the water depth, but also being stopped in the end of its path. (author)

  12. The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours.

    Science.gov (United States)

    Varley, J M; Armour, J; Swallow, J E; Jeffreys, A J; Ponder, B A; T'Ang, A; Fung, Y K; Brammar, W J; Walker, R A

    1989-06-01

    We have analysed the organisation of the retinoblastoma (RB1) gene in 77 primary breast carcinomas, in metastatic tissue derived from 16 of those primary tumours, and in a variety of benign breast lesions. Expression of RB1 was also assessed in most samples by immunohistochemical detection of the RB1 protein in tissue sections. Structural abnormalities to RB1 were detected in DNA from 15/77 (19%) of primary breast carcinomas examined. Where DNA was available from metastatic tissue derived from such primary tumours, the same aberration could be detected. No alterations were seen in benign breast lesions. 16/56 (29%) of tumours examined for expression by immunohistochemical methods showed a proportion of tumour cells to be completely negative for the RB1 protein. All tumours in which a structural alteration to RB1 was detected had a proportion of negative cells, except for one case where all cells were positive. Several primary tumour samples were identified where there was no detectable structural change to the gene, but there was loss of expression in some tumour cells. The data presented here demonstrate that changes to the RB1 gene leading to loss of expression of both alleles are frequent in primary human breast tumours.

  13. Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family

    Energy Technology Data Exchange (ETDEWEB)

    Liban, Tyler J.; Medina, Edgar M.; Tripathi, Sarvind; Sengupta, Satyaki; Henry, R. William; Buchler, Nicolas E.; Rubin, Seth M. (UCSC); (Duke); (MSU)

    2017-04-24

    The retinoblastoma protein (Rb) and the homologous pocket proteins p107 and p130 negatively regulate cell proliferation by binding and inhibiting members of the E2F transcription factor family. The structural features that distinguish Rb from other pocket proteins have been unclear but are critical for understanding their functional diversity and determining why Rb has unique tumor suppressor activities. We describe here important differences in how the Rb and p107 C-terminal domains (CTDs) associate with the coiled-coil and marked-box domains (CMs) of E2Fs. We find that although CTD–CM binding is conserved across protein families, Rb and p107 CTDs show clear preferences for different E2Fs. A crystal structure of the p107 CTD bound to E2F5 and its dimer partner DP1 reveals the molecular basis for pocket protein–E2F binding specificity and how cyclin-dependent kinases differentially regulate pocket proteins through CTD phosphorylation. Our structural and biochemical data together with phylogenetic analyses of Rb and E2F proteins support the conclusion that Rb evolved specific structural motifs that confer its unique capacity to bind with high affinity those E2Fs that are the most potent activators of the cell cycle.

  14. Polymerase chain reaction detection of retinoblastoma gene deletions in paraffin-embedded mouse lung adenocarcinomas

    International Nuclear Information System (INIS)

    Churchill, M.E.; Gemmell, M.A.; Woloschak, G.E.

    1991-01-01

    A Polymerase chain reaction (PCR) technique was used to detect deletions in the mouse retinoblastoma (mRb) gene using microtomed sections from paraffin-embedded radiation-induced and spontaneous tumors as the DNA source. Six mRb gene exon fragments were amplified in a 40-cycle, 3-temperature PCR protocol. Absence of any of these fragments relative to control PCR products on a Southern blot indicated a deletion of that portion of the mRb gene. Tumors chosen for analysis were lung adenocarcinomas that were judged to be the cause of death. Spontaneous tumors as well as those from irradiated mice (569 cGy of 60 Co γ rays or 60 cGy of JANUS neutrons) were analyzed. Tumors in six neutron-irradiated mice also had no mRb deletions. However, one of six tumors from γ-irradiated mice and 6 of 18 spontaneous tumors from unirradiated mice showed a deletion in one or both mRb alleles. All deletions detected were in the 5' region of the mRb gene

  15. The LXCXE Retinoblastoma Protein-Binding Motif of FOG-2 Regulates Adipogenesis.

    Science.gov (United States)

    Goupille, Olivier; Penglong, Tipparat; Kadri, Zahra; Granger-Locatelli, Marine; Denis, Raphaël; Luquet, Serge; Badoual, Cécile; Fucharoen, Suthat; Maouche-Chrétien, Leila; Leboulch, Philippe; Chrétien, Stany

    2017-12-19

    GATA transcription factors and their FOG cofactors play a key role in tissue-specific development and differentiation, from worms to humans. Mammals have six GATA and two FOG factors. We recently demonstrated that interactions between retinoblastoma protein (pRb) and GATA-1 are crucial for erythroid proliferation and differentiation. We show here that the LXCXE pRb-binding site of FOG-2 is involved in adipogenesis. Unlike GATA-1, which inhibits cell division, FOG-2 promotes proliferation. Mice with a knockin of a Fog2 gene bearing a mutated LXCXE pRb-binding site are resistant to obesity and display higher rates of white-to-brown fat conversion. Thus, each component of the GATA/FOG complex (GATA-1 and FOG-2) is involved in pRb/E2F regulation, but these molecules have markedly different roles in the control of tissue homeostasis. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  16. Restrictions in daily life after retinoblastoma from the perspective of the survivors.

    Science.gov (United States)

    van Dijk, Jennifer; Oostrom, Kim J; Huisman, Jaap; Moll, Annette C; Cohen-Kettenis, Peggy T; Ringens, Peter J; Imhof, Saskia M

    2010-01-01

    Little is known about the impact of retinoblastoma (RB) on the health status of survivors in terms of disabilities and worries, both of which may restrict participation in activities of daily life. In this population-based cross-sectional study, content analysis was used to extract data on perceived restrictions and worries, from semi-structured interviews held with 156 RB survivors aged 8-35 years. The International Classification of Functioning Disabilities and Health (ICF) was used as a framework. Of all survivors, 55% perceive RB-related restrictions in daily life activities (school, professional career, mobility, self-care, intimate relationships). Young/adolescent survivors (6%) and adult survivors (15%) frequently report anxiety about developing a second primary tumor (SPT). Compared with the general population, RB survivors did not differ in rates of employment or marital status. However, special educational services were more frequently offered, and the level of completed education was lower. RB has influenced the lives of most survivors and, even though their prognosis was good, illness-related restrictions are common. Especially fear of developing SPT and of further loss of vision are important life-long problems, and many survivors had special education needs. The ICF might serve as a bridge between families and professionals, because this classification may facilitate early detection of problems. Copyright 2009 Wiley-Liss, Inc.

  17. A Bistable Circuit Involving SCARECROW-RETINOBLASTOMA Integrates Cues to Inform Asymmetric Stem Cell Division

    Science.gov (United States)

    Cruz-Ramírez, Alfredo; Díaz-Triviño, Sara; Blilou, Ikram; Grieneisen, Verônica A.; Sozzani, Rosangela; Zamioudis, Christos; Miskolczi, Pál; Nieuwland, Jeroen; Benjamins, René; Dhonukshe, Pankaj; Caballero-Pérez, Juan; Horvath, Beatrix; Long, Yuchen; Mähönen, Ari Pekka; Zhang, Hongtao; Xu, Jian; Murray, James A.H.; Benfey, Philip N.; Bako, Laszlo; Marée, Athanasius F.M.; Scheres, Ben

    2012-01-01

    SUMMARY In plants, where cells cannot migrate, asymmetric cell divisions (ACDs) must be confined to the appropriate spatial context. We investigate tissue-generating asymmetric divisions in a stem cell daughter within the Arabidopsis root. Spatial restriction of these divisions requires physical binding of the stem cell regulator SCARECROW (SCR) by the RETINOBLASTOMA-RELATED (RBR) protein. In the stem cell niche, SCR activity is counteracted by phosphorylation of RBR through a cyclinD6;1-CDK complex. This cyclin is itself under transcriptional control of SCR and its partner SHORT ROOT (SHR), creating a robust bistable circuit with either high or low SHR-SCR complex activity. Auxin biases this circuit by promoting CYCD6;1 transcription. Mathematical modeling shows that ACDs are only switched on after integration of radial and longitudinal information, determined by SHR and auxin distribution, respectively. Coupling of cell-cycle progression to protein degradation resets the circuit, resulting in a “flip flop” that constrains asymmetric cell division to the stem cell region. PMID:22921914

  18. Dosimetric evaluation in heterogeneous tissue of anterior electron beam irradiation for treatment of retinoblastoma

    International Nuclear Information System (INIS)

    Kirsner, S.M.; Hogstrom, K.R.; Kurup, R.G.; Moyers, M.F.

    1987-01-01

    A dosimetric study of anterior electron beam irradiation for treatment of retinoblastoma was performed to evaluate the influence of tissue heterogeneities on the dose distribution within the eye and the accuracy of the dose calculated by a pencil beam algorithm. Film measurements were made in a variety of polystyrene phantoms and in a removable polystyrene eye incorporated into a tissue substitute phantom constructed from a human skull. Measurements in polystyrene phantoms were used to demonstrate the algorithm's ability to predict the effect of a lens block placed in the beam, as well as the eye's irregular surface shape. The eye phantom was used to measure dose distributions within the eye in both the sagittal and transverse planes in order to test the algorithm's ability to predict the dose distribution when bony heterogeneities are present. Results show (1) that previous treatment planning conclusions based on flat, uniform phantoms for central-axis depth dose are adequate; (2) that a three-dimensional heterogeneity correction is required for accurate dose calculations; and (3) that if only a two-dimensional heterogeneity correction is used in calculating the dose, it is more accurate for the sagittal than the transverse plane

  19. Overview of recurrent chromosomal losses in retinoblastoma detected by low coverage next generation sequencing

    Science.gov (United States)

    García-Chequer, A.J.; Méndez-Tenorio, A.; Olguín-Ruiz, G.; Sánchez-Vallejo, C.; Isa, P.; Arias, C.F.; Torres, J.; Hernández-Angeles, A.; Ramírez-Ortiz, M.A.; Lara, C.; Cabrera-Muñoz, M.L.; Sadowinski-Pine, S.; Bravo-Ortiz, J.C.; Ramón-García, G.; Diegopérez-Ramírez, J.; Ramírez-Reyes, G.; Casarrubias-Islas, R.; Ramírez, J.; Orjuela, M.A.; Ponce-Castañeda, M.V.

    2016-01-01

    Genes are frequently lost or gained in malignant tumors and the analysis of these changes can be informative about the underlying tumor biology. Retinoblastoma is a pediatric intraocular malignancy, and since deletions in chromosome 13 have been described in this tumor, we performed genome wide sequencing with the Illumina platform to test whether recurrent losses could be detected in low coverage data from DNA pools of Rb cases. An in silico reference profile for each pool was created from the human genome sequence GRCh37p5; a chromosome integrity score and a graphics 40 Kb window analysis approach, allowed us to identify with high resolution previously reported non random recurrent losses in all chromosomes of these tumors. We also found a pattern of gains and losses associated to clear and dark cytogenetic bands respectively. We further analyze a pool of medulloblastoma and found a more stable genomic profile and previously reported losses in this tumor. This approach facilitates identification of recurrent deletions from many patients that may be biological relevant for tumor development. PMID:26883451

  20. Alteration of the retinoblastoma gene locus in radium-exposed individuals

    International Nuclear Information System (INIS)

    Hardwick, J.P.; Schlenker, R.; Huberman, E.

    1991-01-01

    This study was performed to determine if the retinoblastoma suppressor gene was altered in individuals exposed to radium. We analyzed the Rb gene in 30 individuals, 17 of whom were exposed to radium either occupationally or iatrogenically. In the kidney DNA from four of nine radium-exposed individuals, the Rb gene was deleted. Three of these alterations in the Rb gene were internal deletions, which resulted in the absence of Rb mRNA accumulation. These results imply that the Rb gene is susceptible to radium-induced damage and confirm previous showing that radiation preferentially causes genomic deletions. The pronounced alterations in the non-tumorigenic femurs from radium-exposed individuals suggests that in the many years of exposure there was a selection of cells with alterations, presumably because of their growth advantage. Also it implies that deletions of one of the Rb alleles can be one of the events (perhaps an initial one) in the progression of radium-induced sarcomas. 11 refs., 2 figs