Ulysses directives in The Netherlands: opinions of psychiatrists and clients.

Science.gov (United States)

Varekamp, I

2004-12-01

In this article we present a study on the opinions of Dutch psychiatrists and clients on Ulysses directives. In-depth interviews were conducted with 18 clients and 17 psychiatrists. Most respondents were proponents of Ulysses directives. The most frequently mentioned objective of these directives was to secure timely admission to hospital, although a large minority was mainly interested in giving patients influence on treatment decisions. Psychiatrists differed on how much autonomy they preferred with regard to decisions about the moment of admission and kind of treatment. Clients also differed in this respect. Pressure from others to execute a Ulysses directive, and premature admission to the hospital were mentioned as risks of Ulysses directives. Crisis cards were seen as an alternative by many psychiatrists and some clients. Recommendations are made for a good functioning of Ulysses directives, and the appropriateness of crisis cards as an alternative for a number of patients is discussed.

The Ulysses mission: An introduction

International Nuclear Information System (INIS)

Marsden, R.G.

1996-01-01

On 30 September 1995, Ulysses completed its initial, highly successful, survey of the polar regions of the heliosphere in both southern and northern hemispheres, thereby fulfilling its prime mission. The results obtained to date are leading to a revision of many earlier ideas concerning the solar wind and the heliosphere. Now embarking on the second phase of the mission, Ulysses will continue along its out-of-ecliptic flight path for another complete orbit of the Sun. In contrast to the high-latitude phase of the prime mission, which occurred near solar minimum, the next polar passes (in 2000 and 2001) will take place when the Sun is at its most active

Low-Latitude Solar Wind During the Fall 1998 SOHO-Ulysses Quadrature

Science.gov (United States)

Poletto, G.; Suess, S. T.; Biesecker, D. A.; Esser, R.; Gloeckler, G.; Ko, Y.-K.; Zurbuchen, T. H.

2002-01-01

Solar and Heliospheric Observatory (SOH0)-Ulysses quadratures occur when the SOHO-Sun-Ulysses-included angle is 90 deg. These offer the opportunity to directly compare properties of plasma parcels, observed by SOHO [Dorningo et al.] in the low corona, with properties of the same parcels measured, in due time, in situ, by Ulysses [ Wenzel et al]. We refer the reader to Suess et al. for an extended discussion of SOHO-Ulysses quadrature geometry. Here it suffices to recall that there are two quadratures per year, as SOHO makes its one-year revolution around the Sun. This, because SOHO is at the L1 Lagrangian point, in essentially the same place as the Earth, while Ulysses is in a near-polar -5-year solar orbit with a perihelion of 1.34 AU and aphelion of 5.4 AU.

Ulysses arrangements in psychiatry: a matter of good care?

NARCIS (Netherlands)

Gremmen, I.; Widdershoven, G.A.M.; Beekman, A.T.F.; Zuijderhoudt, R.H.; Sevenhuijsen, S.

2008-01-01

This article concerns the issue of how an ethic of care perspective may contribute to both normative theory and mental health care policy discussions on so called Ulysses arrangements, a special type of advance directives in psychiatry. The debate on Ulysses arrangements has predominantly been waged

Ulysses Arrangements in psychiatry: A matter of good care?

NARCIS (Netherlands)

Gremmen, C.C.M.; Widdershoven, G.G; Beekman, A; Zuijderhoudt, R.; Sevenhuijsen, S.

2008-01-01

This article concerns the issue of how an ethic of care perspective may contribute to both normative theory and mental health care policy discussions on so called Ulysses arrangements, a special type of advance directives in psychiatry. The debate on Ulysses arrangements has predominantly been waged

EXPLORING THE POSSIBILITY OF O AND Ne CONTAMINATION IN ULYSSES OBSERVATIONS OF INTERSTELLAR HELIUM

International Nuclear Information System (INIS)

Wood, Brian E.; Müller, Hans-Reinhard; Bzowski, Maciej; Sokół, Justyna M.; Möbius, Eberhard; Witte, Manfred; McComas, David J.

2015-01-01

We explore the possibility that interstellar O and Ne may be contributing to the particle signal from the GAS instrument on Ulysses, which is generally assumed to be entirely He. Motivating this study is the recognition that an interstellar temperature higher than any previously estimated from Ulysses data could potentially resolve a discrepancy between Ulysses He measurements and those from the Interstellar Boundary Explorer (IBEX). Contamination by O and Ne could lead to Ulysses temperature measurements that are too low. We estimate the degree of O and Ne contamination necessary to increase the inferred Ulysses temperature to 8500 K, which would be consistent with both the Ulysses and IBEX data given the same interstellar flow speed. We find that producing the desired effect requires a heavy element contamination level of ∼9% of the total Ulysses/GAS signal. However, this degree of heavy element contribution is about an order of magnitude higher than expected based on our best estimates of detection efficiencies, ISM abundances, and heliospheric survival probabilities, making it unlikely that heavy element contamination is significantly affecting temperatures derived from Ulysses data

EXPLORING THE POSSIBILITY OF O AND Ne CONTAMINATION IN ULYSSES OBSERVATIONS OF INTERSTELLAR HELIUM

Energy Technology Data Exchange (ETDEWEB)

Wood, Brian E. [Naval Research Laboratory, Space Science Division, Washington, DC 20375 (United States); Müller, Hans-Reinhard [Department of Physics and Astronomy, Dartmouth College, Hanover, NH 03755 (United States); Bzowski, Maciej; Sokół, Justyna M. [Space Research Centre of the Polish Academy of Sciences, Ul. Bartycka 18 A, 00-716 Warsaw (Poland); Möbius, Eberhard [Space Science Center and Department of Physics, University of New Hampshire, Durham, NH 03824 (United States); Witte, Manfred [Max-Planck-Institute for Solar System Research, Katlenburg-Lindau (Germany); McComas, David J., E-mail: brian.wood@nrl.navy.mil [Southwest Research Institute, San Antonio, TX 78228 (United States)

2015-10-15

We explore the possibility that interstellar O and Ne may be contributing to the particle signal from the GAS instrument on Ulysses, which is generally assumed to be entirely He. Motivating this study is the recognition that an interstellar temperature higher than any previously estimated from Ulysses data could potentially resolve a discrepancy between Ulysses He measurements and those from the Interstellar Boundary Explorer (IBEX). Contamination by O and Ne could lead to Ulysses temperature measurements that are too low. We estimate the degree of O and Ne contamination necessary to increase the inferred Ulysses temperature to 8500 K, which would be consistent with both the Ulysses and IBEX data given the same interstellar flow speed. We find that producing the desired effect requires a heavy element contamination level of ∼9% of the total Ulysses/GAS signal. However, this degree of heavy element contribution is about an order of magnitude higher than expected based on our best estimates of detection efficiencies, ISM abundances, and heliospheric survival probabilities, making it unlikely that heavy element contamination is significantly affecting temperatures derived from Ulysses data.

A Ulysses Detection of Secondary Helium Neutrals

Science.gov (United States)

Wood, Brian E.; Müller, Hans-Reinhard; Witte, Manfred

2017-12-01

The Interstellar Boundary EXplorer (IBEX) mission has recently studied the flow of interstellar neutral He atoms through the solar system and discovered the existence of a secondary He flow that likely originates in the outer heliosheath. We find evidence for this secondary component in Ulysses data. By coadding hundreds of Ulysses He beam maps together to maximize signal-to-noise ratio, we identify a weak signal that is credibly associated with the secondary component. Assuming a laminar flow from infinity, we infer the following He flow parameters: V=12.8+/- 1.9 km s-1, λ =74\\buildrel{\\circ}\\over{.} 4+/- 1\\buildrel{\\circ}\\over{.} 8, β =-10\\buildrel{\\circ}\\over{.} 5+/- 4\\buildrel{\\circ}\\over{.} 1, and T=3000+/- 1100 K; where λ and β are the ecliptic longitude and latitude direction in J2000 coordinates. The secondary component has a density that is 4.9 ± 0.9% that of the primary component. These measurements are reasonably consistent with measurements from IBEX, with the exception of temperature, where our temperature is much lower than IBEX’s T = 9500 K. Even the higher IBEX temperature is suspiciously low compared to expectactions for the outer heliosheath source region. The implausibly low temperatures are due to the incorrect assumption of a laminar flow instead of a diverging one, given that the flow in the outer heliosheath source region will be deflecting around the heliopause. As for why the IBEX and Ulysses T values are different, difficulties with background subtraction in the Ulysses data are a potential source of concern, but the discrepancy may also be another effect of the improper laminar flow assumption, which could affect the IBEX and Ulysses analyses differently.

Making a clean break: addiction and Ulysses contracts.

Science.gov (United States)

Andreou, Chrisoula

2008-01-01

I examine current models of self-destructive addictive behaviour, and argue that there is an important place for Ulysses contracts in coping with addictive behaviour that stems from certain problematic preference structures. Given the relevant preference structures, interference based on a Ulysses contract need not involve questionably favouring an agent's past preferences over her current preferences, but can actually be justified in terms of the agent's current concerns and commitments.

Ulysses directives in The Netherlands: opinions of psychiatrists and clients

NARCIS (Netherlands)

Varekamp, I.

2004-01-01

In this article we present a study on the opinions of Dutch psychiatrists and clients on Ulysses directives. In-depth interviews were conducted with 18 clients and 17 psychiatrists. Most respondents were proponents of Ulysses directives. The most frequently mentioned objective of these directives

Ulysses transposable element of Drosophila shows high structural similarities to functional domains of retroviruses.

Science.gov (United States)

Evgen'ev, M B; Corces, V G; Lankenau, D H

1992-06-05

We have determined the DNA structure of the Ulysses transposable element of Drosophila virilis and found that this transposon is 10,653 bp and is flanked by two unusually large direct repeats 2136 bp long. Ulysses shows the characteristic organization of LTR-containing retrotransposons, with matrix and capsid protein domains encoded in the first open reading frame. In addition, Ulysses contains protease, reverse transcriptase, RNase H and integrase domains encoded in the second open reading frame. Ulysses lacks a third open reading frame present in some retrotransposons that could encode an env-like protein. A dendrogram analysis based on multiple alignments of the protease, reverse transcriptase, RNase H, integrase and tRNA primer binding site of all known Drosophila LTR-containing retrotransposon sequences establishes a phylogenetic relationship of Ulysses to other retrotransposons and suggests that Ulysses belongs to a new family of this type of elements.

James Joyce's Ulysses: The Search for Value

Directory of Open Access Journals (Sweden)

Aouda Aljohani

2014-01-01

Full Text Available Two chapters, "Scylla and Charybdis" and "Penelope," in James Joyce's Ulysses are crucial to an understanding of the novel as a whole. "Scylla and Charybdis" stands midway in the novel, the ninth of eighteen chapters, and is designed to serve as a kind of exegesis of the writer's methods and intentions. An analysis of that chapter helps to explain the meaning of the controversial final chapter, "Penelope," and to clarify its thematic and stylistic relation to the text as a whole. Ulysses is the story of a quest, actually of many quests that all coalesce into a single goal: the search for value in a modern world that is somehow diminished and constructed in comparison with the Homeric world where mortals strode the universe in company with gods and goddesses. How, in this dwarfed setting, can men and women redefine heroism in secular humanistic terms relevant to twentieth-century life? Almost by definition a quest narrative culminates in the attainment of the goal or in the potential for its attainment; Joyce's Ulysses affirms this possibility in "Penelope."

Preliminary Results from Coordinated UVCS-CDS-Ulysses Observations

Science.gov (United States)

Parenti, S.; Bromage, B. J.; Poletto, G.; Suess, S. T.; Raymond, J. C.; Noci, G.; Bromage, G. E.; Rose, M. Franklin (Technical Monitor)

2001-01-01

The June 2000 quadrature between the Sun, Earth, and Ulysses took place with Ulysses at a distance of 3.35 AU from the Sun and at heliocentric latitude 58.2 deg south, in the southeast quadrant. This provided an opportunity to observe the corona close to the Sun with Coronal Diagnostic Spectrometer (CDS) and Ultraviolet Coronograph Spectrometer (UVCS) and, subsequently, to sample the same plasma when it reached Ulysses. Here we focus on simultaneous observations of UVCS and CDS made on June 12, 13, 16 and 17. The UVCS data were acquired at heliocentric altitudes ranging from 1.6 to 2.2 solar radii, using different grating positions, in order to get a wide wavelength range. CDS data consisted of Normal Incidence Spectrometer (NIS) full wavelength rasters of 120" x 150" centered at altitudes up to 1.18 solar radii, together with Grazing Incidence Spectrometer (GIS) 4" x 4" rasters within the same field of view, out to 1.2 solar radii. The radial direction to Ulysses passed through a high latitude streamer, throughout the 4 days of observations, Analysis of the spectra taken by UVCS shows a variation of the element abundances in the streamer over our observing interval: however, because the observations were in slightly different parts of the streamer on different days, the variation could be ascribed either to a temporal or spatial effect. The oxygen abundance, however, seems to increase at the edge of the streamer, as indicated by previous analyses. This suggests the variation may be a function of position within the streamer, rather than a temporal effect. Oxygen abundances measured by SWICS on Ulysses are compared with the CDS and UVCS results to see whether changes measured in situ follow the same pattern.

[Ulysses retrotransposon aspartate proteinase (Drosophila virilis)].

Science.gov (United States)

Volkov, D A; Savvateeva, L V; Dergousova, N I; Rumsh, L D

2002-01-01

Retrotransposones are mobile genetic elements occurring in genomes of bacteria, plants or animals. Retrotransposones were found to contain nucleotide sequences encoding proteins which are homological to retroviral aspartic proteinases. Our research has been focused on Ulysses which is mobile genetic element found in Drosophila virilis. We suggested a primary structure of Ulysses proteinase using comparative analysis of amino acid sequences of retroviral proteinases and proteinases from retrotransposones. The appropriate cDNA fragment has been cloned and expressed in E. coli. The purification of recombinant protein (12 kD) has been carried out by affinity chromatography using pepstatine-agarose. The obtained protein has proteolytic activity at optimum pH 5.5 like the majority of aspartic proteinases.

Ulysses(*) reaches the South Pole of the Sun

Science.gov (United States)

1994-08-01

One of the many investigations being carried out is a search for the Sun's south magnetic pole. As in the case of the Earth, the magnetic pole is offset from the rotation axis, and at some time in September it should sweep directly into line with Ulysses. Just as the polar regions of the Earth were the last to be explored, so it is with the Sun. For more than thirty years spacecraft have investigated the stream of electric particles know as the solar wind. Ulysses, developed by ESA, built by European Industry and flown in collaboration with NASA, is the first to fly through the solar wind coming from the poles. As Ulysses reaches its highest solar latitude of 80.2 degrees on 13 September, European and American researchers will gather at the ESA/ESTEC, the European Space Research and Technology Centre in Noordwijk, the Netherlands, for a scientific workshop at which they will assess the results from the nine experiments carried by the spacecraft. For the week of the workshop, the ESA/ESTEC conference centre will be transformed into a busy scientific laboratory. The large meeting rooms will be divided into 24 working areas, where the Ulysses experiment teams will take up temporary residence. Bringing a variety of computing equipment with them, the scientists will be able to retrieve the latest data from the spacecraft and perform detailed analyses. The emphasis will be on informality, with exchange of scientific ideas - and data - the key ingredient, leading ultimately to a better understanding of the fascinating information being gathered by Ulysses on its unique exploratory journey. Presentations to the media at ESA/ESTEC will start at 10h00 on 16 September. Media representatives wishing to attend are kindly requested to fill out the attached form and return it - preferably by fax (+33.1.42.73.76.90) - to : ESA Public Relations Division, 8/10, rue Mario Nikis - 75015-PARIS. Note to Television Editors : A video index, containing extensive background material on the

Ulysses Patera

Science.gov (United States)

2002-01-01

[figure removed for brevity, see original site] (Released 18 July 2002) It is helpful to look at the context for this THEMIS image, which covers a large area over the summit of Ulysses Patera. Ulysses Patera is one of the many volcanoes that make up the giant Tharsis volcanic province, although Ulysses itself is fairly small in comparison to the other volcanoes in this area. In the context image, there are 3 circular features near the top of the volcano. The large, central feature is called a 'caldera', and is the result of volcanic activity at Ulysses. The other two circular features are impact craters. The THEMIS image primarily spans across the central caldera, but also covers a portion of the northernmost impact crater. We know that the large central caldera must have formed earlier than the two craters, because its circular form has been cut by the smaller crater rims. In the THEMIS image, there are stair-stepping plateaus in the northern portion of the image. These are part of the rim of the northern crater, and are caused by collapse or subsidence after the impact event. Just to the south of this crater, 'rayed' patterns can be seen on part of the caldera floor. The rayed pattern is most likely due to a landslide of material down the crater rim slope. Another possibility is that the impact that formed the northern crater caused material to be ejected radially, and then parts of the ejecta have either been buried or eroded away. Other signs of mass movement events in this image are dark streaks, caused by dust avalanches, visible in the caldera's northern wall. In the central portion of the image, there are two lobe-shaped features-one overlaps the other-that appear to have flowed westward. It is likely that these features are ejecta lobes, because they are located adjacent to the southeastern crater (see context image). The fluidized appearance of these ejecta lobes is probably due to a significant amount of ice or water being present in the soil at the time

Gamma-ray burst observations with the Compton/Ulysses/Pioneer-Venus network

International Nuclear Information System (INIS)

Cline, T.L.; Hurley, K.C.; Sommer, M.; Boer, M.; Niel, M.; Fishman, G.J.; Kouveliotou, C.; Meegan, C.A.; Paciesas, W.S.; Wilson, R.B.; Fenimore, E.E.; Laros, J.G.; Klebesadel, R.W.

1993-01-01

The third and latest interplanetary network for the precise directional analysis of gamma ray bursts consists of the Burst and Transient Source Experiment in Compton Gamma Ray Observatory and instruments on Pioneer-Venus Orbiter and the deep-space mission Ulysses. The unsurpassed resolution of the BATSE instrument, the use of refined analysis techniques, and Ulysses' distance of up to 6 AU all contribute to a potential for greater precision than had been achieved with former networks. Also, the departure of Ulysses from the ecliptic plane in 1992 avoids any positional alignment of the three instruments that would lessen the source directional accuracy

A Detection of the Same Hot Plasma in the Corona: During a CME and Later at Ulysses

Science.gov (United States)

Suess, S. T.; Poletto, G.

2004-01-01

We show direct evidence for the same very hot plasma being detected remotely from SOHO in the corona and subsequently, at Ulysses in the solar wind. This is, to our knowledge, the first time that such an unambiguous identification has been made in the case of hot plasma. This detection complements studies correlating other plasma and field properties observed to the properties measured at the source in the corona. This observation takes advantage of a SOHO-Sun-Ulysses quadrature, during which the Sun-Ulysses included angle is $90^\\circ$ and it is possible to observe with Ulysses instruments the same plasma that has previously been remotely observed with SOHO instruments in the corona on the limb of the Sun. The identification builds on an existing base of separate SOHO and interplanetary detections of hot plasma. SOHO/UVCS has found evidence for very hot coronal plasma in current sheets in the aftermath of CMEs in the [Fe XVIII] $\\lambda$ \\AA\\ line, implying a temperature on the order of $6\\times 10(exp 6)$ K. This temperature is unusually high even for active regions, but is compatible with the high temperature predicted in current sheets. In the solar wind, ACE data from early 1998 to middle 2000 revealed high frozen-in Fe charge state in many cases to be present in interplanetary plasma.

SOHO-Ulysses Coordinated Studies During the Two Extended Quadratures and the Radial Alignment of 2007-2008

Science.gov (United States)

Suess, S. T.; Poletto, G.

2007-01-01

During quadrature, plasma seen on the limb of the Sun, along the radi al direction to Ulysses, by SOHO or STEREO can be sampled in situ as lt later passes Ulysses. A figure shows a coronagraph image, the rad ial towards Ulysses at 58 deg. S. and the SOHO/UVCS slit positions d uring one set of observations. A CME subsequently occurred and passed Ulysses (at 3/4 AU) 15 days later.

The solar wind neon abundance observed with ACE/SWICS and ULYSSES/SWICS

International Nuclear Information System (INIS)

Shearer, Paul; Raines, Jim M.; Lepri, Susan T.; Thomas, Jonathan W.; Gilbert, Jason A.; Landi, Enrico; Zurbuchen, Thomas H.; Von Steiger, Rudolf

2014-01-01

Using in situ ion spectrometry data from ACE/SWICS, we determine the solar wind Ne/O elemental abundance ratio and examine its dependence on wind speed and evolution with the solar cycle. We find that Ne/O is inversely correlated with wind speed, is nearly constant in the fast wind, and correlates strongly with solar activity in the slow wind. In fast wind streams with speeds above 600 km s –1 , we find Ne/O = 0.10 ± 0.02, in good agreement with the extensive polar observations by Ulysses/SWICS. In slow wind streams with speeds below 400 km s –1 , Ne/O ranges from a low of 0.12 ± 0.02 at solar maximum to a high of 0.17 ± 0.03 at solar minimum. These measurements place new and significant empirical constraints on the fractionation mechanisms governing solar wind composition and have implications for the coronal and photospheric abundances of neon and oxygen. The results are made possible by a new data analysis method that robustly identifies rare elements in the measured ion spectra. The method is also applied to Ulysses/SWICS data, which confirms the ACE observations and extends our view of solar wind neon into the three-dimensional heliosphere.

The solar wind neon abundance observed with ACE/SWICS and ULYSSES/SWICS

Energy Technology Data Exchange (ETDEWEB)

Shearer, Paul; Raines, Jim M.; Lepri, Susan T.; Thomas, Jonathan W.; Gilbert, Jason A.; Landi, Enrico; Zurbuchen, Thomas H. [Department of Atmospheric, Oceanic, and Space Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Von Steiger, Rudolf [International Space Science Institute, Hallerstrasse 6, CH-3012 Bern (Switzerland)

2014-07-01

Using in situ ion spectrometry data from ACE/SWICS, we determine the solar wind Ne/O elemental abundance ratio and examine its dependence on wind speed and evolution with the solar cycle. We find that Ne/O is inversely correlated with wind speed, is nearly constant in the fast wind, and correlates strongly with solar activity in the slow wind. In fast wind streams with speeds above 600 km s{sup –1}, we find Ne/O = 0.10 ± 0.02, in good agreement with the extensive polar observations by Ulysses/SWICS. In slow wind streams with speeds below 400 km s{sup –1}, Ne/O ranges from a low of 0.12 ± 0.02 at solar maximum to a high of 0.17 ± 0.03 at solar minimum. These measurements place new and significant empirical constraints on the fractionation mechanisms governing solar wind composition and have implications for the coronal and photospheric abundances of neon and oxygen. The results are made possible by a new data analysis method that robustly identifies rare elements in the measured ion spectra. The method is also applied to Ulysses/SWICS data, which confirms the ACE observations and extends our view of solar wind neon into the three-dimensional heliosphere.

Menstruation in Ulysses.

Science.gov (United States)

Mullin, Katherine

2008-01-01

This article investigates James Joyce's fascination with a wide variety of medical texts, sexual folklores, religious beliefs, and persistent superstitions about menstruation. That fascination finds its way into Ulysses, which draws upon a number of intertexts to inform a curiosity about the female body most strikingly articulated by Bloom, Molly, and Gerty MacDowell. These intertexts are not simply imported into the novel but are dismantled and interrogated, as Joyce exposes, rather than endorses, clichés of essential femininity.

The hot plasma environment at jupiter: ulysses results.

Science.gov (United States)

Lanzerotti, L J; Armstrong, T P; Gold, R E; Anderson, K A; Krimigis, S M; Lin, R P; Pick, M; Roelof, E C; Sarris, E T; Simnett, G M; Maclennan, C G; Choo, H T; Tappin, S J

1992-09-11

Measurements of the hot plasma environment during the Ulysses flyby of Jupiter have revealed several new discoveries related to this large rotating astrophysical system. The Jovian magnetosphere was found by Ulysses to be very extended, with the day-side magnetopause located at approximately 105 Jupiter radii. The heavy ion (sulfur, oxygen, and sodium) population in the day-side magnetosphere increased sharply at approximately 86 Jupiter radii. This is somewhat more extended than the "inner" magnetosphere boundary region identified by the Voyager hot plasma measurements. In the day-side magnetosphere, the ion fluxes have the anisotropy direction expected for corotation with the planet, with the magnitude of the anisotropy increasing when the spacecraft becomes more immersed in the hot plasma sheet. The relative abundances of sulfur, oxygen, and sodium to helium decreased somewhat with decreasing radial distance from the planet on the day-side, which suggests that the abundances of the Jupiter-derived species are dependent on latitude. In the dusk-side, high-latitude region, intense fluxes of counter-streaming ions and electrons were discovered from the edge of the plasma sheet to the dusk-side magnetopause. These beams of electrons and ions were found to be very tightly aligned with the magnetic field and to be superimposed on a time- and space-variable isotropic hot plasma background. The currents carried by the measured hot plasma particles are typically approximately 1.6 x 10(-4) microamperes per square meter or approximately 8 x 10(5) amperes per squared Jupiter radius throughout the high-latitude magnetosphere volume. It is likely that the intense particle beams discovered at high Jovian latitudes produce auroras in the polar caps of the planet.

Omnidirectional light absorption of disordered nano-hole structure inspired from Papilio ulysses.

Science.gov (United States)

Wang, Wanlin; Zhang, Wang; Fang, Xiaotian; Huang, Yiqiao; Liu, Qinglei; Bai, Mingwen; Zhang, Di

2014-07-15

Butterflies routinely produce nanostructured surfaces with useful properties. Here, we report a disordered nano-hole structure with ridges inspired by Papilio ulysses that produce omnidirectional light absorption compared with the common ordered structure. The result shows that the omnidirectional light absorption is affected by polarization, the incident angle, and the wavelength. Using the finite-difference time-domain (FDTD) method, the stable omnidirectional light absorption is achieved in the structure inspired from the Papilio ulysses over a wide incident angle range and with various wavelengths. This explains some of the mysteries of the structure of the Papilio ulysses butterfly. These conclusions can guide the design of omnidirectional absorption materials.

Ulysses S. Grant and Reconstruction.

Science.gov (United States)

Wilson, David L.

1989-01-01

Discusses the role played by Ulysses S. Grant during the four years of Reconstruction before he became President of the United States. Describes the dynamics of the relationship between Grant and Andrew Johnson. Points out that Grant's attitude of service to the laws created by Congress submerged his desire to create a new South. (KO)

Nationalism in James Joyce's Ulysses

Directory of Open Access Journals (Sweden)

Bahee Hadaegh

2016-03-01

Full Text Available In the present article, the role of nationalism and postcolonialism in James Joyce's Ulysses is explored. The novel is used to reveal the political and postcolonial layers of Joyce's work and represent how colonization works through politics. This helps the readers to realize more about political Joyce and to apprehend his political views as a fresh reading of his oeuvre. The significance of this article is to depict how an author from a colonized society is influenced by the colonizing forces and cultural invasions and to scrutinize the very psychology of a colonized nation. This task is done through Attridge and Howes's methodology as the theoretical framework containing key roles in analyzing the main discussion. Through analyzing Ulysses, this article clearly shows that Joyce was a part of nationalistic movements such as the Irish Revival; however he had major conflicts with some individuals and movements that claimed to be nationalists. Therefore, Joyce is concluded to be a 'semicolonial' writer who has his own specific mode of nationalism.

The Ulysses Project. Integrating the Curriculum.

Science.gov (United States)

Smith, Susan Swenton

2001-01-01

Offers a project developed as an outgrowth of sixth-grade students' study of ancient Greece in history, English, drama, and art classes. Explains that the students created sculptures inspired by Greek sculpture that represented student perceptions of the activities and emotions found in the Ulysses myth. (CMK)

Observations of recurrent cosmic ray decreases during solar cycles 22 and 23

International Nuclear Information System (INIS)

Dunzlaff, P.; Heber, B.; Kopp, A.; Rother, O.; Mueller-Mellin, R.; Klassen, A.; Gomez-Herrero, R.; Wimmer-Schweingruber, R.

2008-01-01

During solar cycle 22, the modulation of several hundred MeV galactic cosmic rays (GCRs) by recurrent and transient cosmic ray decreases was observed by the Ulysses spacecraft on its descent towards the solar south pole. In solar cycle 23, Ulysses repeated this trajectory segment during a similar phase of the solar cycle, but with opposite heliospheric magnetic field polarity. Since cosmic ray propagation in the heliosphere should depend on drift effects, we determine in this study the latitudinal distribution of the amplitude of recurrent cosmic ray decreases in solar cycles 22 and 23. As long as we measure the recurrent plasma structures in situ, we find that these decreases behave nearly the same in both cycles. Measurements in the fast solar wind, however, show differences: in cycle 22 (A>0) the recurrent cosmic ray decreases show a clear maximum near 25 and are still present beyond 40 , whereas we see in cycle 23 (A<0) neither such a pronounced maximum nor significant decreases above 40 . In other words: the periodicity in the cosmic ray intensity, which can be clearly seen in the slow solar wind, appears to vanish there. Theoretical models for drift effects, however, predict quite the opposite behaviour for the two solar cycles. To closer investigate this apparent contradiction, we first put the visual inspection of the data onto a more solid basis by performing a detailed Lomb (spectral) analysis. The next step consists of an analysis of the resulting periodicities at 1 AU in order to distinguish between spatial and temporal variations, so that we can obtain statements about the question in how far there is a correlation between the in-situ data at 1 AU and those measured by Ulysses at larger latitudes. We find a good correlation being present during cycle 22, but not for cycle 23. As one potential explanation for this behaviour, we suggest the difference in the coronal hole structures between the cycles 22 and 23 due to a large, stable coronal hole

Children’s understanding of the Ulysses conflict

Science.gov (United States)

Choe, Katherine S.; Keil, Frank C.; Bloom, Paul

2011-01-01

Two studies explored children’s understanding of how the presence of conflicting mental states in a single mind can lead people to act so as to subvert their own desires. Study 1 analyzed explanations by children (4–7 years) and adults of behaviors arising from this sort of ‘Ulysses conflict’ and compared them with their understanding of conflicting desires in different minds, as well as with changes of mind within an individual across time. The data revealed that only the adults were able to adequately explain the Ulysses conflict. Study 2 asked children (4–7 years) and adults to choose among three explicitly presented competing explanations for self-subverting behaviors. The results suggest that an understanding of the influence of conflicting mental states on behaviors does not occur until at least 7 years of age. PMID:16048510

Ulysses dust measurements near Jupiter.

Science.gov (United States)

Grün, E; Zook, H A; Baguhl, M; Fechtig, H; Hanner, M S; Kissel, J; Lindblad, B A; Linkert, D; Linkert, G; Mann, I B

1992-09-11

Submicrometer- to micrometer-sized particles were recorded by the Ulysses dust detector within 40 days of the Jupiter flyby. Nine impacts were recorded within 50 Jupiter radii with most of them recorded after closest approach. Three of these impacts are consistent with particles on prograde orbits around Jupiter and the rest are believed to have resulted from gravitationally focused interplanetary dust. From the ratio of the impact rate before the Jupiter flyby to the impact rate after the Jupiter flyby it is concluded that interplanetary dust particles at the distance of Jupiter move on mostly retrograde orbits. On 10 March 1992, Ulysses passed through an intense dust stream. The dust detector recorded 126 impacts within 26 hours. The stream particles were moving on highly inclined and apparently hyperbolic orbits with perihelion distances of >5 astronomical units. Interplanetary dust is lost rather quickly from the solar system through collisions and other mechanisms and must be almost continuously replenished to maintain observed abundances. Dust flux measurements, therefore, give evidence of the recent rates of production from sources such as comets, asteroids, and moons, as well as the possible presence of interstellar grains.

ULYSSES IN THE DIVINE COMEDY – HELL – A COMPARISON OF THE HERO IN DANTE, HOMER AND VIRGIL

Directory of Open Access Journals (Sweden)

Alysson Ramos Artuso

2016-07-01

Full Text Available Ulysses is a constant character in Western literature and Dante Alighieri was an author that rework him. In the Divine Comedy, Ulysses is in Hell, in the eighth ditch of the eighth circle, corresponding to the fraudsters. In the construction of this character, Dante recovered Ulysses characteristics from Greek and Latin tradition, which is analyzed and compared in this article with the Homer’s and Virgil’s characters. At the end, Ulysses and Dantes - author and character of Comedy – are related.

Preliminary spatial analysis of combined BATSE/Ulysses gamma-ray burst locations

International Nuclear Information System (INIS)

Kippen, R. Marc; Hurley, Kevin; Pendleton, Geoffrey N.

1998-01-01

We present the preliminary spatial analysis of 278 bursts that have been localized by BATSE and the two-spacecraft Compton/Ulysses Interplanetary Network. The large number and superior accuracy of the combined BATSE/Ulysses locations provides improved sensitivity to small-angle source properties. We find that the locations are consistent with large- and small-scale isotropy, with no significant small-angle clustering. We constrain the fraction of sources in clusters and discuss the implications for burst repetition

Spectral analysis of Jupiter kilometric radio emissions during the Ulysses flyby

Science.gov (United States)

Echer, M. P. D. S.; Echer, E.; Gonzalez, W.; Magalães, F. P.

2016-12-01

In this work we analyze Ulysses URAP kilometric radio data during Ulysses Jupiter flyby. The interval selected for analysis was from October 1991 to February 1992. URAP 10-min averages of auroral (bkom) and torus (nkom) radio data are used. The wavelet and iterative regression spectral analyses techniques are employed on both data set. The results obtained will enable us to determine the major frequencies present in the auroral and torus data and study their similar and different periodicities.

On fitting the full spectrum of luminous red galaxies by using ULySS and STARLIGHT

International Nuclear Information System (INIS)

Liu Gao-Chao; Lu You-Jun; Chen Xue-Lei; Du Wei; Zhao Yong-Heng

2013-01-01

We select a sample of quiescent luminous red galaxies (LRGs) from the Sloan Digital Sky Survey Data Release 7 with a high signal-to-noise ratio (S/N) to study the consistency of fitting the full spectrum by using different packages, mainly, ULySS and STARLIGHT. The spectrum of each galaxy in the sample is fitted by the full spectrum fitting packages ULySS and STARLIGHT. We find: (1) for spectra with higher S/Ns, the ages of stellar populations obtained from ULySS are slightly older than those from STARLIGHT, and metallicities derived from ULySS are slightly richer than those from STARLIGHT. In general, both packages can give roughly consistent fitting results. (2) For low S/N spectra, it is possible that the fitting by ULySS can become trapped at some local minimum in the parameter space during execution and thus may give unreliable results, but STARLIGHT can still give reliable results. Based on the fitting results of LRGs, we further analyze their star formation history and the relation between their age and velocity dispersion, and find that they agree well with conclusions from previous works

Children's Understanding of the Ulysses Conflict

Science.gov (United States)

Choe, Katherine S.; Keil, Frank C.; Bloom, Paul

2005-01-01

Two studies explored children's understanding of how the presence of conflicting mental states in a single mind can lead people to act so as to subvert their own desires. Study 1 analyzed explanations by children (4-7 years) and adults of behaviors arising from this sort of "Ulysses conflict" and compared them with their understanding of…

Galileo and Ulysses missions safety analysis and launch readiness status

International Nuclear Information System (INIS)

Cork, M.J.; Turi, J.A.

1989-01-01

The Galileo spacecraft will explore the Jupiter system and Ulysses will fly by Jupiter en route to a polar orbit of the sun. Both spacecraft are powered by general purpose heat source radioisotope thermoelectric generators (RTGs). As a result of the Challenger accident and subsequent mission reprogramming, the Galileo and Ulysses missions' safety analysis had to be repeated. In addition to presenting an overview of the safety analysis status for the missions, this paper presents a brief review of the missions' objectives and design approaches, RTG design characteristics and development history, and a description of the safety analysis process. (author)

Evolution of cosmic ray fluxes during the rising phase of solar cycle 23: ULYSSES EPAC and COSPIN/KET observations

International Nuclear Information System (INIS)

Heber, B.; Keppler, E.; Blake, J.B.; Fraenz, M.; Kunow, H.

2000-01-01

Galactic cosmic rays are entering the heliosphere from the interstellar medium, while anomalous cosmic rays are believed to be pickup ions accelerated at the heliospheric termination shock. Both particle species are modulated by the solar wind and the heliospheric magnetic field. Since 1997 solar activity increased and as a consequence the flux of galactic and anomalous cosmic ray decreased. In this paper we will discuss the variation of low energy anomalous cosmic rays as measured by the Ulysses Energetic Particle Composition Experiment (EPAC) and the Kiel Electron Telescope (KET) on board Ulysses. Specifically we are addressing the question: Are there differences in the modulation of galactic and anomalous cosmic rays and what are possible implication for the modulation of cosmic rays in the heliosphere?

SOHO-Ulysses Coordinated Studies During the Two Extended Quadratures and the Alignment of 2007-2008

Science.gov (United States)

Suess, S. T.; Poletto, G.

2007-01-01

During SOHO-Sun-Ulysses quadratures the geometry of the configuration makes it possible to sample "in situ" the plasma parcels that are remotely observed in the corona. Although the quadrature position occurs at a well defined instant in time, we typically take data while Ulysses is within +/- 5 degrees of the limb, with the understanding that plasma sampled by Ulysses over this time interval can all be traced to its source in the corona. The relative positions of SOHO and Ulysses in winter 2007 (19 Dec 2006-28 May 2007) are unusual: the SOHO-Sun-Ulysses included angle is always between 85 and 95 degrees - the quadrature lasts for 5 months! This provides an opportunity for extended observations of specific observing objectives. In addition, in summer 2007, Ulysses (at 1.34 AU) is in near-radial alignment with Earth/ACE/Wind and SOHO, allowing us to analyze radial gradients and propagation in the solar wind and inner heliosphere. Our own quadrature campaigns rely heavily on LASCO and UVCS coronal observations: LASCO giving the overall context above 2 solar radii while the UVCS spectrograph acquired data from - 1.5 to, typically, 4-5 solar radii. In the past, coronal parameters have been derived from data acquired by these two experiments and compared with "in situ" data of Ulysses' SWOOPS and SWICS. Data from other experiments like EIT, CDS, SUMER, Sac Peak Fe XIV maps, magnetic field maps from the Wilcox solar magnetograph, MLSO, from MDI, and from the Ulysses magnetograph experiment have been, and will be, used to complement LASCO/UVCS/SWOOPS and SWICS data. We anticipate that observations by ACE/WIND/STEREO/Hinode and other missions will be relevant as well. During the IHY campaigns, Ulysses will be 52-80 degrees south in winter 2007, near sunspot minimum. Hence, our own scientific objective will be to sample high speed wind or regions of transition between slow and fast wind. This might be a very interesting situation - not met in previous quadratures - allowing

Neutral interstellar helium parameters based on Ulysses/GAS and IBEX-LO observations: What are the reasons for the differences?

International Nuclear Information System (INIS)

Katushkina, O. A.; Izmodenov, V. V.; Wood, B. E.; McMullin, D. R.

2014-01-01

Recent analysis of the interstellar helium fluxes measured in 2009-2010 at Earth's orbit by the Interstellar Boundary Explorer (IBEX) has suggested that the interstellar velocity (both direction and magnitude) is inconsistent with that derived previously from Ulysses/GAS observations made in the period from 1990 to 2002 at 1.5-5.5 AU from the Sun. Both results are model dependent, and models that were used in the analyses are different. In this paper, we perform an analysis of the Ulysses/GAS and IBEX-Lo data using our state-of-the-art three-dimensional time-dependent kinetic model of interstellar atoms in the heliosphere. For the first time, we analyze Ulysses/GAS data from year 2007, the closest available Ulysses/GAS observations in time to the IBEX observations. We show that the interstellar velocity derived from the Ulysses 2007 data is consistent with previous Ulysses results and does not agree with the velocity derived from IBEX. This conclusion is very robust since, as is shown in the paper, it does not depend on the ionization rates adopted in theoretical models. We conclude that Ulysses data are not consistent with the new local interstellar medium (LISM) velocity vector from IBEX. In contrast, IBEX data, in principle, could be explained with the LISM velocity vector derived from the Ulysses data. This is possible for the models where the interstellar temperature increased from 6300 K to 9000 K. There is a need to perform further studies of possible reasons for the broadening of the helium signal core measured by IBEX, which could be an instrumental effect or could be due to unconsidered physical processes.

Neutral interstellar helium parameters based on Ulysses/GAS and IBEX-LO observations: What are the reasons for the differences?

Energy Technology Data Exchange (ETDEWEB)

Katushkina, O. A.; Izmodenov, V. V. [Space Research Institute, Russian Academy of Sciences, Moscow (Russian Federation); Wood, B. E. [Naval Research Laboratory, Space Science Division, Washington, DC 20375 (United States); McMullin, D. R., E-mail: okat@iki.rssi.ru [Space Systems Research Corporation, Alexandria, VA 22314 (United States)

2014-07-01

Recent analysis of the interstellar helium fluxes measured in 2009-2010 at Earth's orbit by the Interstellar Boundary Explorer (IBEX) has suggested that the interstellar velocity (both direction and magnitude) is inconsistent with that derived previously from Ulysses/GAS observations made in the period from 1990 to 2002 at 1.5-5.5 AU from the Sun. Both results are model dependent, and models that were used in the analyses are different. In this paper, we perform an analysis of the Ulysses/GAS and IBEX-Lo data using our state-of-the-art three-dimensional time-dependent kinetic model of interstellar atoms in the heliosphere. For the first time, we analyze Ulysses/GAS data from year 2007, the closest available Ulysses/GAS observations in time to the IBEX observations. We show that the interstellar velocity derived from the Ulysses 2007 data is consistent with previous Ulysses results and does not agree with the velocity derived from IBEX. This conclusion is very robust since, as is shown in the paper, it does not depend on the ionization rates adopted in theoretical models. We conclude that Ulysses data are not consistent with the new local interstellar medium (LISM) velocity vector from IBEX. In contrast, IBEX data, in principle, could be explained with the LISM velocity vector derived from the Ulysses data. This is possible for the models where the interstellar temperature increased from 6300 K to 9000 K. There is a need to perform further studies of possible reasons for the broadening of the helium signal core measured by IBEX, which could be an instrumental effect or could be due to unconsidered physical processes.

Half Sinful Words: Disguised Grief in "Ulysses."

Science.gov (United States)

Hobbs, Michael

As a shrewd technician of the language, A. L. Tennyson rightly understood that words are not controllable; they do not always obey rules. As Tennyson said, words "half reveal and half conceal the soul within." In "Ulysses," the title character's speech to his fellow mariners--where he attempts to explain why he has decided to…

Nuclear risk analysis of the Ulysses mission

International Nuclear Information System (INIS)

Bartram, B.W.; Vaughan, F.R.; Englehart, D.R.W.

1991-01-01

The use of a radioisotope thermoelectric generator fueled with plutonium-238 dioxide on the Space Shuttle-launched Ulysses mission implies some level of risk due to potential accidents. This paper describes the method used to quantify risks in the Ulysses mission Final Safety Analysis Report prepared for the U.S. Department of Energy. The starting point for the analysis described herein is following input of source term probability distributions from the General Electric Company. A Monte Carlo technique is used to develop probability distributions of radiological consequences for a range of accident scenarios thoughout the mission. Factors affecting radiological consequences are identified, the probability distribution of the effect of each factor determined, and the functional relationship among all the factors established. The probability distributions of all the factor effects are then combined using a Monte Carlo technique. The results of the analysis are presented in terms of complementary cumulative distribution functions (CCDF) by mission sub-phase, phase, and the overall mission. The CCDFs show the total probability that consequences (calculated health effects) would be equal to or greater than a given value

Qualification of GPHS-RTG for the Galileo and Ulysses missions

International Nuclear Information System (INIS)

Cockfield, R.D.

1986-01-01

The General Purpose Heat Source - Radioisotope Thermoelectric Generator (GPHS-RTG)- was designed and built by General Electric under the sponsorship of the Department of Energy, Office of Special Nuclear Projects, to power both the Galileo and Ulysses spacecraft. Separate STS launches of these two spacecraft were planned for May, l986, but have now been delayed. Galileo will carry two RTGs, providing over 5l0 watts of electrical power at the end of a 4.2 year mission, and Ulysses' single RTG will provide over 250 watts of electrical power at the end of a 4.7 year mission. These power levels and mission durations may differ for delayed launch schedules. To ensure that the GPHS-RTG is qualified for the Galileo and Ulysses missions, a formal program, consisting of extensive analyses, inspections, demonstrations, and tests, was conducted. Requirements for qualification included such categories as electrical performance, life characteristics, dynamic capability, thermal characteristics, active cooling system performance, magnetic properties, nuclear criticality, gas management provisions, electrostatic cleanliness, mass properties, neutron emission rate, and micrometeoroid survivability. This paper addresses selected topics from this list and presents data to show that anticipated performance will meet or exceed design requirements as specified for a May, l986 launch

Combined Ulysses Solar Wind and SOHO Coronal Observations of Several West Limb Coronal Mass Ejections. Appendix 8

Science.gov (United States)

Funsten, H. O.; Gosling, J. T.; Riley, P.; St.Cyr, O. C.; Forsyth, R. J.; Howard, R. A.; Schwenn, R.

2001-01-01

From October 1996 to January 1997, Ulysses was situated roughly above the west limb of the Sun as observed from Earth at a heliocentric distance of about 4.6 AU and a latitude of about 25 deg. This presents the first opportunity to compare Solar and Heliospheric Observatory (SOHO) limb observations of coronal mass ejections (CMEs) directly with their solar wind counterparts far from the Sun using the Ulysses data. During this interval, large eruptive events were observed above the west limb of the Sun by the Large Angle Spectrometric Coronagraph (LASCO) on SOHO on October 5, November 28, and December 21-25, 1996. Using the combined plasma and magnetic field data from Ulysses, the October 5 event was clearly identified by several distinguishing signatures as a CME. The November 28 event was also identified as a CME that trailed fast ambient solar wind, although it was identified only by an extended interval of counterstreaming suprathermal electrons. The December 21 event was apparently characterized by a six-day interval of nearly radial field and a plasma rarefaction. For the numerous eruptive events observed by the LASCO coronagraph during December 23-25, Ulysses showed no distinct, CMEs, perhaps because of intermingling of two or more of the eruptive events. By mapping the Ulysses observations back in time to the Sun assuming a constant flow speed, we have identified intervals of plasma that were accelerated or decelerated between the LASCO and Ulysses observations.

The HUS solar flare and cosmic gamma-ray burst detector aboard the Ulysses spacecraft

International Nuclear Information System (INIS)

Boer, M.; Sommer, M.; Hurley, K.

1990-02-01

An overview of the instruments and of the scientific objectives of the Ulysses spacecraft is given. The experiment consists of two detectors: Two Si sensors operating in the range 5-20 keV, and two CsI (Tl) scintillators for the range 15-200 keV. The bit rate of the HUS experiment in the Ulysses telemetry is 40 bits/seconds and the time resolution is up to 4 s for the Si sensors and up to 8 ms for the scintillators. The total mass is 2.02 kg. The scientific objectives of the Ulysses mission are investigations on the physics of solar flares, such as their impulsive energy release, the heating and particle acceleration, the storage and the energy transport. The experiment will take place during the next solar maximum of 1991. (orig./HM)

Jupiter's Magnetosphere: Plasma Description from the Ulysses Flyby.

Science.gov (United States)

Bame, S J; Barraclough, B L; Feldman, W C; Gisler, G R; Gosling, J T; McComas, D J; Phillips, J L; Thomsen, M F; Goldstein, B E; Neugebauer, M

1992-09-11

Plasma observations at Jupiter show that the outer regions of the Jovian magnetosphere are remarkably similar to those of Earth. Bow-shock precursor electrons and ions were detected in the upstream solar wind, as at Earth. Plasma changes across the bow shock and properties of the magnetosheath electrons were much like those at Earth, indicating that similar processes are operating. A boundary layer populated by a varying mixture of solar wind and magnetospheric plasmas was found inside the magnetopause, again as at Earth. In the middle magnetosphere, large electron density excursions were detected with a 10-hour periodicity as planetary rotation carried the tilted plasma sheet past Ulysses. Deep in the magnetosphere, Ulysses crossed a region, tentatively described as magnetically connected to the Jovian polar cap on one end and to the interplanetary magnetic field on the other. In the inner magnetosphere and lo torus, where corotation plays a dominant role, measurements could not be made because of extreme background rates from penetrating radiation belt particles.

De Anima: Or, Ulysses and the Theological Turn in Modernist Studies

Directory of Open Access Journals (Sweden)

David Ayers

2017-08-01

Full Text Available Focusing on Joyce’s use of Aristotle’s De Anima, and on Aquinas’s response to Aristotle, this essay takes, as its starting point, the recourse to two areas of enquiry in recent work on modernism: animal studies and phenomenology. In this essay we examine the intersection within Ulysses of the concept of the soul in Aristotle and Aquinas, show how this relates to questions of animality, and open the way to asking what implication the theological reflection on the soul at the centre of Ulysses might have for a process of uncovering theological contents in the concept of “life” in modernist studies more generally.

Open solar flux estimates from near-Earth measurements of the interplanetary magnetic field: comparison of the first two perihelion passes of the Ulysses spacecraft

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M. Lockwood

2004-04-01

Full Text Available Results from all phases of the orbits of the Ulysses spacecraft have shown that the magnitude of the radial component of the heliospheric field is approximately independent of heliographic latitude. This result allows the use of near-Earth observations to compute the total open flux of the Sun. For example, using satellite observations of the interplanetary magnetic field, the average open solar flux was shown to have risen by 29% between 1963 and 1987 and using the aa geomagnetic index it was found to have doubled during the 20th century. It is therefore important to assess fully the accuracy of the result and to check that it applies to all phases of the solar cycle. The first perihelion pass of the Ulysses spacecraft was close to sunspot minimum, and recent data from the second perihelion pass show that the result also holds at solar maximum. The high level of correlation between the open flux derived from the various methods strongly supports the Ulysses discovery that the radial field component is independent of latitude. We show here that the errors introduced into open solar flux estimates by assuming that the heliospheric field's radial component is independent of latitude are similar for the two passes and are of order 25% for daily values, falling to 5% for averaging timescales of 27 days or greater. We compare here the results of four methods for estimating the open solar flux with results from the first and second perehelion passes by Ulysses. We find that the errors are lowest (1–5% for averages over the entire perehelion passes lasting near 320 days, for near-Earth methods, based on either interplanetary magnetic field observations or the aa geomagnetic activity index. The corresponding errors for the Solanki et al. (2000 model are of the order of 9–15% and for the PFSS method, based on solar magnetograms, are of the order of 13–47%. The model of Solanki et al. is based on the continuity equation of open flux, and uses the

Imaging Obsearvations of Jupiter's Sodium Magneto-Nebula During the Ulysses Encounter.

Science.gov (United States)

Mendillo, M; Flynn, B; Baumgardner, J

1992-09-11

Jupiter's great sodium nebula represents the largest visible structure traversed by the Ulysses spacecraft during its encounter with the planet in February 1992. Ground-based imaging conducted on Mount Haleakala, Hawaii, revealed a nebula that extended to at least +/-300 Jovian radii (spanning approximately 50 million kilometers); it was somewhat smaller in scale and less bright than previously observed. Analysis of observations and results of modeling studies suggest reduced volcanic activity on the moon lo, higher ion temperatures in the plasma torus, lower total plasma content in the torus, and fast neutral atomic clouds along the Ulysses inbound trajectory through the magnetosphere. Far fewer neutrals were encountered by the spacecraft along its postencounter, out-of-ecliptic trajectory.

Faults and ridges - Historical development in Tempe Terra and Ulysses Patera regions of Mars

International Nuclear Information System (INIS)

Scott, D.H.; Dohm, J.M.

1990-01-01

Tempe Terra and the area north of Ulysses Patera are selected to demonstrate the various stages of faulting and ridge development in local areas. This work is accomplished by using Viking photomosaics to determine crosscutting relations of structures as well as their morphology and trend orientations. Results show that from the Early Noachian through the Early Amazonian Epochs, at least eight episodes of faulting occurred at Tempe Terra and six at Ulysses Patera. Tectonic activity at Tempe Terra was expressed mainly by densely spaced faults along the northeast extension of the Tharsis rise; faulting culminated in the Middle and Late Noachian and was superseded by transverse fault systems from the Alba Patera region during the Hesperian. Ridge formation, however, was most active in the Early Hesperian. At Ulysses Patera, an early history of tectonism is recorded by complex arrays of faults in a relatively small area of Noachian rocks. 14 refs

Conduct and results of the Interagency Nuclear Safety Review Panel's evaluation of the Ulysses space mission

International Nuclear Information System (INIS)

Sholtis, J.A. Jr.; Gray, L.B.; Huff, D.A.; Klug, N.P.; Winchester, R.O.

1991-01-01

The recent 6 October 1990 launch and deployment of the nuclear-powered Ulysses spacecraft from the Space Shuttle Discovery culminated an extensive safety review and evaluation effort by the Interagency Nuclear Safety Review Panel (INSRP). After more than a year of detailed independent review, study, and analysis, the INSRP prepared a Safety Evaluation Report (SER) on the Ulysses mission, in accordance with Presidential Directive-National Security Council memorandum 25. The SER, which included a review of the Ulysses Final Safety Analysis Report (FSAR) and an independent characterization of the mission risks, was used by the National Aeronautics and Space Administration (NASA) in its decision to request launch approval as well as by the Executive Office of the President in arriving at a launch decision based on risk-benefit considerations. This paper provides an overview of the Ulysses mission and the conduct as well as the results of the INSRP evaluation. While the mission risk determined by the INSRP in the SER was higher than that characterized by the Ulysses project in the FSAR, both reports indicated that the radiological risks were relatively small. In the final analysis, the SER proved to be supportive of a positive launch decision. The INSRP evaluation process has demonstrated its effectiveness numerous times since the 1960s. In every case, it has provided the essential ingredients and perspective to permit an informed launch decision at the highest level of our Government

Ulysses observations of a 'density hole' in the high-speed solar wind

International Nuclear Information System (INIS)

Riley, P.; Gosling, J.T.; McComas, D.J.; Forsyth, R.J.

1998-01-01

Ulysses observations at mid and high heliographic latitudes have revealed a solar wind devoid of the large variations in density, temperature, and speed that are commonly observed at low latitudes. One event, however, observed on May 1, 1996, while Ulysses was located at ∼3.7AU and 38.5 degree, stands out in the plasma data set. The structure, which is unique in the Ulysses high-latitude data set, is seen as a drop in proton density of almost an order of magnitude and a comparable rise in proton temperature. The event lasts ∼3(1)/(2) hours giving the structure a size of ∼9.6x10 6 km (0.06 AU) along the spacecraft trajectory. Minimum variance analysis of this interval indicates that the angle between the average magnetic field direction and the minimum variance direction is ∼92 degree, suggesting that the 'density hole' may be approximated by a series of planar slabs separated by several tangential discontinuities. We discuss several possible explanations for the origin of this structure, but ultimately the origin of the density hole remains unknown. copyright 1998 American Geophysical Union

Ulysses and the Signature of Things

OpenAIRE

Dukes, Hunter

2017-01-01

James Joyce’s depiction of autographic signatures resembles the “doctrine of signatures” — a pre-modern system of correspondence between medicinal plants and parts of the body. Certain aspects of this episteme reappear in the late nineteenth century. This recurrence is due, in large part, to developments in the technology of writing that threaten what Friedrich Kittler calls the “surrogate sensuality of handwriting.” Reading the “Nausicaa” episode of Ulysses against fin-de-siècle ideas about ...

Ulysses Observations of Nonlinear Wave-wave Interactions in the ...

Indian Academy of Sciences (India)

tribpo

The Ulysses Unified Radio and Plasma Wave Experiment. (URAP) has observed Langmuir, ... gesting that strong turbulence processes, such as modulational instability and soliton formation, often coexist ... Solar and interplanetary type III radio bursts, which occur at the fundamental and the second harmonic of the electron ...

New aspartic proteinase of Ulysses retrotransposon from Drosophila virilis.

Science.gov (United States)

Volkov, D A; Dergousova, N I; Rumsh, L D

2004-06-01

This work is focused on the investigation of a proteinase of Ulysses mobile genetic element from Drosophila virilis. The primary structure of this proteinase is suggested based on comparative analysis of amino acid sequences of aspartic proteinases from retroviruses and retrotransposons. The corresponding cDNA fragment has been cloned and expressed in E. coli. The protein accumulated in inclusion bodies. The recombinant protein (12 kD) was subjected to refolding and purified by affinity chromatography on pepstatin-agarose. Proteolytic activity of the protein was determined using oligopeptide substrates melittin and insulin B-chain. It was found that the maximum of the proteolytic activity is displayed at pH 5.5 as for the majority of aspartic proteinases. We observed that hydrolysis of B-chain of insulin was totally inhibited by pepstatin A in the micromolar concentration range. The molecular weight of the monomer of the Ulysses proteinase was determined by MALDI-TOF mass-spectrometry.

SPATIALLY DEPENDENT HEATING AND IONIZATION IN AN ICME OBSERVED BY BOTH ACE AND ULYSSES

Energy Technology Data Exchange (ETDEWEB)

Lepri, Susan T. [Department of Atmospheric, Oceanic and Space Sciences, University of Michigan, Ann Arbor, MI 48109-2143 (United States); Laming, J. Martin; Rakowski, Cara E. [Space Science Division, Naval Research Laboratory, Code 7674L, Washington, DC 20375-5321 (United States); Von Steiger, Rudolf [International Space Science Institute, Bern CH-3012 (Switzerland)

2012-12-01

The 2005 January 21 interplanetary coronal mass ejection (ICME) observed by multiple spacecraft at L1 was also observed from January 21-February 4 at Ulysses (5.3 AU). Previous studies of this ICME have found evidence suggesting that the flanks of a magnetic cloud like structure associated with this ICME were observed at L1 while a more central cut through the associated magnetic cloud was observed at Ulysses. This event allows us to study spatial variation across the ICME and relate it to the eruption at the Sun. In order to examine the spatial dependence of the heating in this ICME, we present an analysis and comparison of the heavy ion composition observed during the passage of the ICME at L1 and at Ulysses. Using SWICS, we compare the heavy ion composition across the two different observation cuts through the ICME and compare it with predictions for heating during the eruption based on models of the time-dependent ionization balance throughout the event.

Did Ulysses have porphyria?

Science.gov (United States)

Pierach, Claus A

2004-07-01

Although the biosynthetic pathway to heme has been well elucidated and errors along that route have been identified and firmly connected to specific diseases, the porphyrias, slight but nonspecific abnormalities, are occasionally invoked as proof of porphyria or in support of other diagnoses. An errant patient with a conundrum of symptoms but without an explanation for them might have to take iatrogenic detours only to learn after what are at times ulyssean vagaries that the initial diagnosis of porphyria is in the end untenable. Thus the porphyrias are superb examples of the interface between laboratory and clinical medicine, in which the occurrence of the Ulysses syndrome can be curtailed through the careful ordering of tests and cogent interpretation of their results.

Flight performance of Galileo and Ulysses RTGs

International Nuclear Information System (INIS)

Hemler, R.J.; Kelly, C.E.

1993-01-01

Flight performance data of the GPHS-RTGs (General Purpose Heat Source---Radioisotope Thermoelectric Generators) on the Galileo and Ulysses spacecraft are reported. Comparison of the flight data with analytical predictions is preformed. Differences between actual flight telemetry data and analytical predictions are addressed including the degree of uncertainty associated with the telemetry data. End of mission power level predictions are included for both missions with an overall assessment of RTG mission performances

DO PASTICHE SOBRE SI: ESTILO E ANTROPOMORFISMO NO “NAUSICA”, DE ULYSSES

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Fabio Akcelrud Durão

2014-05-01

Full Text Available Este trabalho parte da ideia apresentada por Kenner de que o Ulysses de Joyce é constituído por duas vozes narrativas que cumprem funções divesas em sua estrutura. A partir da verificação de certas inconsistências na caracterização da protagonista de “Nausicaa”, é defendida então a hipótese de que o episódio seria um caso limite da violência paródica de Ulysses, onde o romance se volta contra sua própria dinâmica básica de funcionamento, trazendo consequências variadas para seus processos de constituição de sentido.

James Joyce’s Trojan Hobby-Horse: The Iliad and the Collective Unconscious Ulysses

Directory of Open Access Journals (Sweden)

Dieter Fuchs

2013-12-01

Full Text Available James Joyce’s Ulysses rewrites the Homeric Odyssey in such a way that the ancient myth provides a structural pattern, which gives order and meaning to a seemingly chaotic and meaningless contemporary world – an aspect which T. S. Eliot called the “mythical method”. As the characters of Ulysses are ignorant of this ordering device, they function as Jungian archetypes rather than individuals: Their deeds correspond to a mythical framework which is not actively remembered but provides a collective unconsciousness that guides their lives as a principle of order and continuity. What they do is meaningful although they consider themselves as insignificant agents thrown into a seemingly chaotic world. Whereas scholars have focused on Homer’s Odyssey as an archetypal (i.e. collective unconscious key to the cultural memory of the mythical roots of Western culture, they have turned a comparatively blind eye to the fact that Homer’s corresponding work of the Iliad has a similar function for the mythopoetic design of Ulysses. This paper is going to reconstruct Joyce’s neglected intertextual dialogue with the Iliad as an archetypal key to the cultural memory of the roots of Western civilisation.

Directives in anorexia nervosa: use of the "Ulysses Agreement".

Science.gov (United States)

Davidson, H; Birmingham, C L

2003-09-01

The course of anorexia nervosa frequently has episodes of exacerbation during which motivation and insight are reduced, cognition is impaired and treatment resistance is increased. Formalizing a directive to be used during these episodes when the patient has greater motivation and insight is one way of reducing treatment resistance. We describe a form of directive, called the "Ulysses Agreement".

Ulysses radio and plasma wave observations at high southern heliographic latitudes.

Science.gov (United States)

Stone, R G; Macdowall, R J; Fainberg, J; Kaiser, M L; Desch, M D; Goldstein, M L; Hoang, S; Bougeret, J L; Harvey, C C; Manning, R; Steinberg, J L; Kellogg, P J; Lin, N; Goetz, K; Osherovich, V A; Reiner, M J; Canu, P; Cornilleau-Wehrlin, N; Lengyel-Frey, D; Thejappa, G

1995-05-19

Ulysses spacecraft radio and plasma wave observations indicate that some variations in the intensity and occurrence rate of electric and magnetic wave events are functions of heliographic latitude, distance from the sun, and phase of the solar cycle. At high heliographic latitudes, solartype Ill radio emissions did not descend to the local plasma frequency, in contrast to the emission frequencies of some bursts observed in the ecliptic. Short-duration bursts of electrostatic and electromagnetic waves were often found in association with depressions in magnetic field amplitude, known as magnetic holes. Extensive wave activity observed in magnetic clouds may exist because of unusually large electron-ion temperature ratios. The lower number of intense in situ wave events at high latitudes was likely due to the decreased variability of the high- latitude solar wind.

On the development of the power sources for the Ulysses and Galileo missions

International Nuclear Information System (INIS)

Bennett, G.L.; Whitmore, C.W.; Amos, W.R.

1989-01-01

The development of the Radioisotope Thermoelectric Generator (RTG) to be used on the Ulysses and Galileo missions is described. This RTG, designed to provide a minimum of 285 We at the beginning of the mission, builds upon the successful thermoelectric technology developed for the RTGs now in operation on the Voyager 1 and 2 spacecraft. A total of four flight RTGs, one ground qualification RTG, and one engineering unit have been built and tested for the Galileo and Ulysses missions. The tests have included measurements of functional performance, vibration response, magnetic signature, mass properties, nuclear radiation, and vacuum performance. The RTGs are fully flight qualified for both missions and are ready for launch

Modelling cosmic ray intensities along the Ulysses trajectory

Directory of Open Access Journals (Sweden)

D. C. Ndiitwani

2005-03-01

Full Text Available Time dependent cosmic ray modulation in the inner heliosphere is studied by comparing results from a 2-D, time-dependent cosmic ray transport model with Ulysses observations. A compound approach, which combines the effects of the global changes in the heliospheric magnetic field magnitude with drifts to establish a realistic time-dependence, in the diffusion and drift coefficients, are used. We show that this model results in realistic cosmic ray modulation from the Ulysses launch (1990 until recently (2004 when compared to 2.5-GV electron and proton and 1.2-GV electron and Helium observations from this spacecraft. This approach is also applied to compute radial gradients present in 2.5-GV cosmic ray electron and protons in the inner heliosphere. The observed latitude dependence for both positive and negative charged particles during both the fast latitude scan periods, corresponding to different solar activity conditions, could also be realistically computed. For this an additional reduction in particle drifts (compared to diffusion toward solar maximum is needed. This results in a realistic charge-sign dependent modulation at solar maximum and the model is also applied to predict charge-sign dependent modulation up to the next expected solar minimum.

Suprathermal electron loss cone distributions in the solar wind: Ulysses observations

International Nuclear Information System (INIS)

Phillips, J. L.; Feldman, W. C.; Gosling, J. T.; Hammond, C. M.; Forsyth, R. J.

1996-01-01

We present observations by the Ulysses solar wind plasma experiment of a new class of suprathermal electron signatures. At low solar latitudes and heliocentric distances beyond 3.37 AU Ulysses encountered seven intervals, ranging in duration from 1 hour to 22 hours, in which the suprathermal distributions included an antisunward field-aligned beam and a return population with a flux dropout typically spanning ±60 deg. from the sunward field-aligned direction. All events occurred between the forward and reverse shocks or waves bounding corotating interaction regions (CIRs). The observations support a scenario in which the sunward-moving electrons result from reflection of the prevailing antisunward field-aligned beam at magnetic field compressions downstream from the spacecraft, with wide loss cones caused by the relatively weak mirror ratio. This hypothesis requires that the field magnitude within the CIRs actually increased locally with increasing field-aligned distance from the Sun

Wide and Narrow CMEs and Their Source Explosions Observed at the Spring 2003 SOHO-Sun-Ulysses Quadrature

Science.gov (United States)

Suess, Steven; Corti, G.; Poletto, G.; Sterling, A.; Moore, R.

2006-01-01

At the time of the spring 2003 Ulysses-SOHO-Sun quadrature, Ulysses was off the East limb of the Sun at 14.5 degrees north latitude and 4.91 AU. LASCO/C2 images show small transient events that originated from near the limb on May 25, 26 and 27 in the north-east quadrant, along with a large Coronal Mass Ejection (CME) that originated from an active region near disk center on May 26. Ulysses data bear clear signatures of the large CME, specifically including an enhanced abundance of highly ionized Fe. SOHO/UVCS spectra at 1.75 solar radii, near the radial direction to Ulysses, give no evidence of emission from high temperature lines, even for the large CME: instead, for the small events, occasional transient high emission in cool lines was observed, such as the CIII 977 Angstrom line usually absent at coronal levels. Each of these events lasted ca. 1 hour or less and never affected lines from ions forming above ca. 106K. Compact eruptions in Helium 304 Angstrom EIT images, related to the small UVCS transients, were observed at the limb of the Sun over the same period. At least one of these surge events produced a narrow CME observed in LASCO/C2. Most probably all these events are compact magnetic explosions (surges/jets, from around a small island of included polarity) which ejected cool material from lower levels. Ulysses data have been analyzed to find evidence of the cool, narrow CME events, but none or little was found. This puzzling scenario, where events seen by UVCS have no in situ counterparts and vice versa, can be partially explained once the region where the large CME originated is recognized as being at the center of the solar disk so that the CME material was actually much further from the Sun than the 1.7 Rsun height of the UVCS slit off the limb. Conversely, the narrow events may simply have missed Ulysses or been too brief for reliable signatures in composition and ionization state. A basic feature demonstrated by these observations is that large

Diversive Narrative Possibilities within the Presumppositional Gestalt of Ulysses

OpenAIRE

Taira, Katsuaki; 平良, 勝明

2010-01-01

Joyce の Ulysses においてその内面、そして外面事象というのは絶えず変化し続けている、といっていいほど極度な disjunctivity（断続性・非連続性）に支配されている。すべてが意識の流れを中心に構築されている世界なので突然の統語論的、ないしは叙述意味論的断続性というのは予想される現象ではあるが、この論文では特に Ulysses の narrative 全体と個々の事象との間に見られる意味論的整合性・非整合性という観点から登場人物、特に Bloom、を介した意識世界に迫ってみた。...

Ulysses spacecraft control and monitoring system

Science.gov (United States)

Hamer, P. A.; Snowden, P. J.

1991-01-01

The baseline Ulysses spacecraft control and monitoring system (SCMS) concepts and the converted SCMS, residing on a DEC/VAX 8350 hardware, are considered. The main functions of the system include monitoring and displaying spacecraft telemetry, preparing spacecraft commands, producing hard copies of experimental data, and archiving spacecraft telemetry. The SCMS system comprises over 20 subsystems ranging from low-level utility routines to the major monitoring and control software. These in total consist of approximately 55,000 lines of FORTRAN source code and 100 VMS command files. The SCMS major software facilities are described, including database files, telemetry processing, telecommanding, archiving of data, and display of telemetry.

How to justify enforcing a Ulysses contract when Ulysses is competent to refuse.

Science.gov (United States)

Davis, John K

2008-03-01

Sometimes the mentally ill have sufficient mental capacity to refuse treatment competently, and others have a moral duty to respect their refusal. However, those with episodic mental disorders may wish to precommit themselves to treatment, using Ulysses contracts known as "mental health advance directives." How can health care providers justify enforcing such contracts over an agent's current, competent refusal? I argue that providers respect an agent's autonomy not retrospectively--by reference to his or her past wishes-and not merely synchronically--so that the agent gets what he or she wants right now-but diachronically and prospectively, acting so that the agent can shape his or her circumstances as the agent wishes over time, for the agent will experience the consequences of providers' actions over time. Mental health directives accomplish this, so they are a way of respecting the agent's autonomy even when providers override the agent's current competent refusal.

Ulysses at jupiter: an overview of the encounter.

Science.gov (United States)

Smith, E J; Wenzel, K P; Page, D E

1992-09-11

In February 1992, the Ulysses spacecraft flew through the giant magnetosphere of Jupiter. The primary objective of the encounter was to use the gravity field of Jupiter to redirect the spacecraft to the sun's polar regions, which will now be traversed in 1994 and 1995. However, the Ulysses scientific investigations were well suited to observations of the Jovian magnetosphere, and the encounter has resulted in a major contribution to our understanding of this complex and dynamic plasma environment. Among the more exciting results are (i) possible entry into the polar cap, (ii) the identification of magnetospheric ions originating from Jupiter's ionosphere, lo, and the solar wind, (iii) observation of longitudinal asymmetries in density and discrete wave-emitting regions of the lo plasma torus, (iv) the presence of counter-streaming ions and electrons, field-aligned currents, and energetic electron and radio bursts in the dusk sector on high-latitude magnetic field lines, and (v) the identification of the direction of the magnetic field in the dusk sector, which is indicative of tailward convection. This overview serves as an introduction to the accompanying reports that present the preliminary scientific findings. Aspects of the encounter that are common to all of the investigations, such as spacecraft capabilities, the flight path past Jupiter, and unique aspects of the encounter, are presented herein.

Electron Heat Flux in Pressure Balance Structures at Ulysses

Science.gov (United States)

Yamauchi, Yohei; Suess, Steven T.; Sakurai, Takashi; Whitaker, Ann F. (Technical Monitor)

2001-01-01

Pressure balance structures (PBSs) are a common feature in the high-latitude solar wind near solar minimum. Rom previous studies, PBSs are believed to be remnants of coronal plumes and be related to network activity such as magnetic reconnection in the photosphere. We investigated the magnetic structures of the PBSs, applying a minimum variance analysis to Ulysses/Magnetometer data. At 2001 AGU Spring meeting, we reported that PBSs have structures like current sheets or plasmoids, and suggested that they are associated with network activity at the base of polar plumes. In this paper, we have analyzed high-energy electron data at Ulysses/SWOOPS to see whether bi-directional electron flow exists and confirm the conclusions more precisely. As a result, although most events show a typical flux directed away from the Sun, we have obtained evidence that some PBSs show bi-directional electron flux and others show an isotropic distribution of electron pitch angles. The evidence shows that plasmoids are flowing away from the Sun, changing their flow direction dynamically in a way not caused by Alfven waves. From this, we have concluded that PBSs are generated due to network activity at the base of polar plumes and their magnetic structures axe current sheets or plasmoids.

Ulysses Data Analysis: Magnetic Topology of Heliospheric Structures

Science.gov (United States)

Crooker, Nancy

2001-01-01

In this final technical report on research funded by a NASA grant, a project overview is given by way of summaries on nine published papers. Research has included: 1) Using suprathermal electron data to study heliospheric magnetic structures; 2) Analysis of magnetic clouds, coronal mass ejections (CME), and the heliospheric current sheet (HCS); 3) Analysis of the corotating interaction region (CIR) which develop from interactions between solar wind streams of different velocities; 4) Use of Ulysses data in the interpretation of heliospheric events and phenomena.

Robinson Crusoe: the fate of the British Ulysses.

Science.gov (United States)

Pimentel, Juan

2010-03-01

If travel has been one of the leitmotifs of Western imagination, Robinson Crusoe has certainly been one of its foremost incarnations. This British Ulysses foretold the global village, but also its problems. He predicted the end of distance, but also the triumph of isolation and anaesthetized loneliness. This paper provides an overview of the connections between Defoe's narrative and the new science and explores two versions of the story by two contemporary writers, Julio Cortazar and John Maxwell Coetzee. 2009 Elsevier Ltd. All rights reserved.

Settling Ulysses: An Adapted Research Agenda for Refugee Mental Health.

Science.gov (United States)

Namer, Yudit; Razum, Oliver

2017-11-08

Refugees and asylum seekers arriving in Europe during the 2015/2016 wave of migration have been exposed to war conditions in their country of origin, survived a dangerous journey, and often struggled with negative reception in transit and host countries. The mental health consequence of such forced migration experiences is named the Ulysses syndrome. Policies regarding the right to residency can play an important role in reducing mental health symptoms. We propose that facilitating a sense of belonging should be seen as one important preventive mental healthcare intervention. A refugee mental health agenda needs to take into account the interplay between refugees' and asylum seekers' mental health, feeling of belonging, and access to healthcare. We urge for policies to restore individuals' dignity, and recognize the right for homecoming to parallel the mythology of Ulysses. © 2018 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Refractive index dependence of Papilio Ulysses butterfly wings reflectance spectra

Science.gov (United States)

Isnaeni, Muslimin, Ahmad Novi; Birowosuto, Muhammad Danang

2016-02-01

We have observed and utilized butterfly wings of Papilio Ulysses for refractive index sensor. We noticed this butterfly wings have photonic crystal structure, which causes blue color appearance on the wings. The photonic crystal structure, which consists of cuticle and air void, is approximated as one dimensional photonic crystal structure. This photonic crystal structure opens potential to several optical devices application, such as refractive index sensor. We have utilized small piece of Papilio Ulysses butterfly wings to characterize refractive index of several liquid base on reflectance spectrum of butterfly wings in the presence of sample liquid. For comparison, we simulated reflectance spectrum of one dimensional photonic crystal structure having material parameter based on real structure of butterfly wings. We found that reflectance spectrum peaks shifted as refractive index of sample changes. Although there is a slight difference in reflectance spectrum peaks between measured spectrum and calculated spectrum, the trend of reflectance spectrum peaks as function of sample's refractive index is the similar. We assume that during the measurement, the air void that filled by sample liquid is expanded due to liquid pressure. This change of void shape causes non-similarity between measured spectrum and calculated spectrum.

Bilingual Obscenities : James Joyce, Ulysses, and the Linguistics of Taboo Words

NARCIS (Netherlands)

Kager, A.M.W.

2016-01-01

James Joyce’s Ulysses has been notorious as a “dirty book” from the moment of its appearance. It was banned on both sides of the Atlantic Ocean for its supposed obscenity and even Joyce’s experimental peers were shocked by its indecent language. Yet Joyce’s earlier works, Dubliners and A Portrait of

The General-Purpose Heat Source Radioisotope Thermoelectric Generator: Power for the Galileo and Ulysses missions

International Nuclear Information System (INIS)

Bennett, G.L.; Lombardo, J.J.; Hemler, R.J.; Peterson, J.R.

1986-01-01

Electrical power for NASA's Galileo mission to Jupiter and ESA's Ulysses mission to explore the polar regions of the Sun will be provided by General-Purpose Heat Source Radioisotope Thermo-electric Generators (GPHS-RTGs). Building upon the successful RTG technology used in the Voyager program, each GPHS-RTG will provide at least 285 W(e) at beginning-of-mission. The design concept has been proven through extensive tests of an electrically heated Engineering Unit and a nuclear-heated Qualification Unit. Four flight generators have been successfully assembled and tested for use on the Galileo and Ulysses spacecraft. All indications are that the GPHS-RTGs will meet or exceed the power requirement of the missions

Ulysses above the sun's south pole: an introduction.

Science.gov (United States)

Smith, E J; Marsden, R G; Page, D E

1995-05-19

Ulysses has explored the field and particle environment of the sun's polar region. The solar wind speed was fast and nearly constant above -50 degrees latitude. Compositional differences were observed in slow (low-latitude) solar wind and in fast (high-latitude) solar wind. The radial magnetic field did not change with latitude, implying that polar cap magnetic fields are transported toward the equator. The intensity of galactic cosmic rays was nearly independent of latitude. Their access to the polar region is opposed by outward-traveling, large amplitude waves in the magnetic field.

Scritto sul vento. Aspetti della questione retorica in Ulysses

Directory of Open Access Journals (Sweden)

Caroline Patey

2010-12-01

Full Text Available Nel capitolo in cui Joyce rilegge e riscrive l’incauta liberazione omerica dei venti contrari, foriera di ulteriori ostacoli al ritorno dei navigatori, il gioioso e scanzonato avvicendamento di tropi e figure – entimema e paranomasia, palindromo e metatesi – capovolge il segno negativo dell’ipotesto e invita a riconsiderare Ulysses alla luce di dialettiche e strategie testuali che ne moltiplicano i sensi e interrogano in modo impellente la forma stessa del genere.

Ulysses - An ESA/NASA cooperative programme

Science.gov (United States)

Meeks, W.; Eaton, D.

1990-01-01

Cooperation between ESA and NASA is discussed, noting that the Memorandum of Understanding lays the framework for this relationship, defining the responsibilities of ESA and NASA and providing for appointment of leadership and managers for the project. Members of NASA's Jet Propulsion Laboratory and ESA's ESTEC staff have been appointed to leadership positions within the project and ultimate control of the project rests with the Joint Working Group consisting of two project managers and two project scientists, equally representing both organizations. Coordination of time scales and overall mission design is discussed, including launch cooperation, public relations, and funding of scientific investigations such as Ulysses. Practical difficulties of managing an international project are discussed such as differing documentation requirements and communication techniques, and assurance of equality on projects.

SIXTEEN YEARS OF ULYSSES INTERSTELLAR DUST MEASUREMENTS IN THE SOLAR SYSTEM. II. FLUCTUATIONS IN THE DUST FLOW FROM THE DATA

International Nuclear Information System (INIS)

Strub, Peter; Krüger, Harald; Sterken, Veerle J.

2015-01-01

The Ulysses spacecraft provided the first opportunity to identify and study interstellar dust (ISD) in situ in the solar system between 1992 and 2007. Here we present the first comprehensive analysis of the ISD component in the entire Ulysses dust data set. We analyzed several parameters of the ISD flow in a time-resolved fashion: flux, flow direction, mass index, and flow width. The general picture is in agreement with a time-dependent focusing/defocusing of the charged dust particles due to long-term variations of the solar magnetic field throughout a solar magnetic cycle of 22 years. In addition, we confirm a shift in dust direction of 50° ± 7° in 2005, along with a steep, size-dependent increase in flux by a factor of 4 within 8 months. To date, this is difficult to interpret and has to be examined in more detail by new dynamical simulations. This work is part of a series of three papers. This paper concentrates on the time-dependent flux and direction of the ISD. In a companion paper we analyze the overall mass distribution of the ISD measured by Ulysses, and a third paper discusses the results of modeling the flow of the ISD as seen by Ulysses

SIXTEEN YEARS OF ULYSSES INTERSTELLAR DUST MEASUREMENTS IN THE SOLAR SYSTEM. II. FLUCTUATIONS IN THE DUST FLOW FROM THE DATA

Energy Technology Data Exchange (ETDEWEB)

Strub, Peter; Krüger, Harald [Max-Planck-Institut für Sonnensystemforschung, Justus-von-Liebig-Weg 3, D-37077 Göttingen (Germany); Sterken, Veerle J., E-mail: krueger@mps.mpg.de [International Space Science Institute, Hallerstrasse 6, 3012 Bern (Switzerland)

2015-10-20

The Ulysses spacecraft provided the first opportunity to identify and study interstellar dust (ISD) in situ in the solar system between 1992 and 2007. Here we present the first comprehensive analysis of the ISD component in the entire Ulysses dust data set. We analyzed several parameters of the ISD flow in a time-resolved fashion: flux, flow direction, mass index, and flow width. The general picture is in agreement with a time-dependent focusing/defocusing of the charged dust particles due to long-term variations of the solar magnetic field throughout a solar magnetic cycle of 22 years. In addition, we confirm a shift in dust direction of 50° ± 7° in 2005, along with a steep, size-dependent increase in flux by a factor of 4 within 8 months. To date, this is difficult to interpret and has to be examined in more detail by new dynamical simulations. This work is part of a series of three papers. This paper concentrates on the time-dependent flux and direction of the ISD. In a companion paper we analyze the overall mass distribution of the ISD measured by Ulysses, and a third paper discusses the results of modeling the flow of the ISD as seen by Ulysses.

THE NOVELS ULYSSES AND TUTUNAMAYANLAR IN POINT OF STREAM OF CONSCIOUSNESS TECHNIQUE / ULYSSES ve TUTUNAMAYANLAR’DA BİLİNÇ AKISI TEKNİĞİ

Directory of Open Access Journals (Sweden)

Dr. Serdar ODACI

2009-01-01

Full Text Available By the modernism in novel, to introduce the innerworld of characters, stream of consciousness is used as anew narration technique. James Joyce has used identicalexamples of stream of consciousness technique inUlysses. The novel Tutunamayanlar written by Oğuz Atayhas an important position for Turkish novel. This novelbelonged to the writer who had followed the way modernism in Turkish literature. In this study these twonovels are examined in point of stream of consciousnesstechnique.

Quid facundia posset / re patuit (Οu., Μet. XIII 382-383: the oratorical strategies of Ulysses in the Ovidian armorum iudicium

Directory of Open Access Journals (Sweden)

Eleonora Tola

2010-12-01

Full Text Available In book XIII of his Metamorphoses Ovid presents the contest for the arms of Achilles between Ajax and Ulysses. The speeches that they address to the assembly of Greek show a judicial process according to the norms of Roman rhetoric. Through his traditional facundia Ulysses persuades his public and gains victory after a confrontation that relates to a verbal fight. I will explore the construction of Ulysses’s discursive superiority focusing especially on two key-places of his speech, exordium (128-139 and peroratio (339-381. I will identify different syntactic, metrical and stylistic strategies with which Ulysses captivates his interlocutors. From a metapoetic perspective, Ovid’s tale establishes some resonances between the character’s Fama and its own textual mechanisms.

Solar Energetic Particle Composition over Two Solar Cycles as Observed by the Ulysses/HISCALE and ACE/EPAM Pulse Height Analyzers.

Science.gov (United States)

Patterson, J. D.; Madanian, H.; Manweiler, J. W.; Lanzerotti, L. J.

2017-12-01

We present the compositional variation in the Solar Energetic Particle (SEP) population in the inner heliosphere over two solar cycles using data from the Ulysses Heliospheric Instrument for Spectra, Composition, and Anisotropy at Low Energies (HISCALE) and Advanced Composition Explorer (ACE) Electron Proton Alpha Monitor (EPAM). The Ulysses mission was active from late 1990 to mid-2009 in a heliopolar orbit inclined by 80° with a perihelion of 1.3 AU and an aphelion of 5.4 AU. The ACE mission has been active since its launch in late 1997 and is in a halo orbit about L1. These two missions provide a total of 27 years of continuous observation in the inner heliosphere with twelve years of simultaneous observation. HISCALE and EPAM data provide species-resolved differential flux and density of SEP between 0.5-5 MeV/nuc. Several ion species (He, C, O, Ne, Si, Fe) are identified using the Pulse Height Analyzer (PHA) system of the Composition Aperture for both instruments. The He density shows a noticeable increase at high solar activity followed by a moderate drop at the quiet time of the solar minimum between cycles 23 and 24. The density of heavier ions (i.e. O and Fe) change minimally with respect to the F10.7 index variations however, certain energy-specific count rates decrease during solar minimum. With Ulysses and ACE observing in different regions of the inner heliosphere, there are significant latitudinal differences in how the O/He ratios vary with the solar cycle. At solar minimum, there is reasonable agreement between the observations from both instruments. At solar max 23, the differences in composition over the course of the solar cycle, and as observed at different heliospheric locations can provide insight to the origins of and acceleration processes differentially affecting solar energetic ions.

Can a subject consent to a 'Ulysses contract'?

Science.gov (United States)

1982-08-01

A case study is presented in which a schizophrenic consents to experimental drug treatment while competent and then refuses the treatment when in a psychotic state. Three commentaries consider the ethical and legal issues involved in permitting informed consent by the mentally ill by means of a "Ulysses contract," i.e., by agreeing at the time of consent that later refusal of treatment is to be ignored if the patient is no longer competent. The commentators see value in such agreements, provided that safeguards are included to ensure that the patient's legitimate wishes and interests are not ignored.

"Their pineal glands aglow": Theosophical physiology in Ulysses.

Science.gov (United States)

Morrisson, Mark S

2008-01-01

This article argues that Joyce's engagements with the Theosophy of the Dublin literary world amount to more than simple parody. In Ulysses, Joyce portrays Theosophy's efforts to offer an alternative understanding of physiology to that of the medical establishment as a form of boundary work, an adaptation of the discourse of modern medical research to fashion modern mysticism as a science. Ultimately, Joyce rejects Theosophical physiology and its evolutionary scientism because it provides an unsatisfactory rhetorical body, a failed attempt to renegotiate the boundaries between scientific materialism and spirituality in the awkward modernity of Dublin in 1904.

[Rethinking the challenges of Ulysses and Faust: health, the individual and history].

Science.gov (United States)

Melo-Filho, D A

1995-01-01

Concentrating on two historical synecdoches, Ulysses and Faust, this article takes up the etymology of the Latin term salute as a unit lying somewhere between "existential needs" and "especially human needs", leading to the challenge of satisfying the need for "conservation of life" and at the same time to "surpass it, go beyond it". Both meanings are present in Ulysses attitude of not succumbing to the siren s melody and in Faust s desire to rise above everyday life. Some aspects of the Marxist conception of the philosophy of history and Althusser s Structuralist Marxism are criticized. Also, in light of Marxist-Hellerian theory, the article analyzes the hypothesis that the target of the final reports of the VIII National Health Conference was "particular man" and not the individual, since health is treated only as "an existential need", and does not envisage the generic human. As a theoretical challenge, the text, in search of the unfolding individual, finally recommends the construction of "epistemological sutures" between nature and society, everyday life and universality, and the young and old Marx.

Electron Pitch-Angle Distribution in Pressure Balance Structures Measured by Ulysses/SWOOPS

Science.gov (United States)

Yamauchi, Yohei; Suess, Steven T.; Sakurai, Takashi; Six, N. Frank (Technical Monitor)

2002-01-01

Pressure balance structures (PBSs) are a common feature in the high-latitude solar wind near solar minimum. From previous studies, PBSs are believed to be remnants of coronal plumes. Yamauchi et al [2002] investigated the magnetic structures of the PBSs, applying a minimum variance analysis to Ulysses/Magnetometer data. They found that PBSs contain structures like current sheets or plasmoids, and suggested that PBSs are associated with network activity such as magnetic reconnection in the photosphere at the base of polar plumes. We have investigated energetic electron data from Ulysses/SWOOPS to see whether bi-directional electron flow exists and we have found evidence supporting the earlier conclusions. We find that 45 ot of 53 PBSs show local bi-directional or isotopic electron flux or flux associated with current-sheet structure. Only five events show the pitch-angle distribution expected for Alfvenic fluctuations. We conclude that PBSs do contain magnetic structures such as current sheets or plasmoids that are expected as a result of network activity at the base of polar plumes.

Ulysses: accurate detection of low-frequency structural variations in large insert-size sequencing libraries.

Science.gov (United States)

Gillet-Markowska, Alexandre; Richard, Hugues; Fischer, Gilles; Lafontaine, Ingrid

2015-03-15

The detection of structural variations (SVs) in short-range Paired-End (PE) libraries remains challenging because SV breakpoints can involve large dispersed repeated sequences, or carry inherent complexity, hardly resolvable with classical PE sequencing data. In contrast, large insert-size sequencing libraries (Mate-Pair libraries) provide higher physical coverage of the genome and give access to repeat-containing regions. They can thus theoretically overcome previous limitations as they are becoming routinely accessible. Nevertheless, broad insert size distributions and high rates of chimerical sequences are usually associated to this type of libraries, which makes the accurate annotation of SV challenging. Here, we present Ulysses, a tool that achieves drastically higher detection accuracy than existing tools, both on simulated and real mate-pair sequencing datasets from the 1000 Human Genome project. Ulysses achieves high specificity over the complete spectrum of variants by assessing, in a principled manner, the statistical significance of each possible variant (duplications, deletions, translocations, insertions and inversions) against an explicit model for the generation of experimental noise. This statistical model proves particularly useful for the detection of low frequency variants. SV detection performed on a large insert Mate-Pair library from a breast cancer sample revealed a high level of somatic duplications in the tumor and, to a lesser extent, in the blood sample as well. Altogether, these results show that Ulysses is a valuable tool for the characterization of somatic mosaicism in human tissues and in cancer genomes. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

[Ulysses contract in psychiatry].

Science.gov (United States)

Daverio, Andrea; Piazzi, Gioia; Saya, Anna

2017-01-01

Over the last twenty years we have witnessed a growing focus on the rights of the ill people. The debate on informed consent and a new redefinition of the therapeutic relationship is constantly evolving. With this article, we propose a critical literature review of the so-called "Ulysses contract" or "psychiatric advance directives". It refers to the will that a subject expresses in writing, or orally, about the treatments he or she wishes or does not wish to be subject to if the time comes when it may be impossible to express his/her consent. This can especially occur in those with psychiatric disorders with serious clinical involvement and remitting-relapse (typically bipolar disorder, but also chronic delusional disorders and schizophrenia). In this context, the question is whether during intercritical periods the patient may or may not leave instructions to their care-givers. This aspect opens up to a series of interdisciplinary problems. In this article, we want to show the complexity of this debate from a clinical, ethical, legal and psychodynamic point of view, emphasizing the strengths and the major criticisms of the psychiatric advance directives for each area.

Recurrent modulation of galactic cosmic ray electrons and protons: Ulysses COSPIN/KET observations

International Nuclear Information System (INIS)

Heber, B.; Blake, J.B.; Paizis, C.; Bothmer, V.; Kunow, H.; Wibberenz, G.; Burger, R.A.; Potgieter, M.S.

2000-01-01

Since measurements of space probes in the interplanetary space became available it has been known that associated with the occurrence of recurrent fast and slow solar wind streams, forming Corotating Interaction Regions, recurrent variations in the cosmic ray nuclei flux are observed. As pointed out recently by Jokipii and Kota (2) recurrent modulation for positively and negatively charged particles may be different. In the time interval extending from July 1992 to July 1994, Ulysses on its journey to high heliographic latitudes registered ∼20 stable and long-lasting Corotating Interaction Regions (CIRs). In this work we use data from the Cosmic Ray and Solar Particle Investigation Kiel Electron Telescope (COSPIN/KET) instrument on board Ulysses to study the recurrent variation of 2.5 GV electrons and protons. We find that 1) electrons are indeed periodically modulated, but that 2) the periodicity of ∼29 days is longer than the period of ∼26 days for protons, and that 3) the amplitude is larger than the one observed for protons

Medicine in the age of " Ulysses ": James Joyce's portrait of life, medicine, and disease on a Dublin day a century ago.

Science.gov (United States)

Shanahan, Fergus; Quigley, Eamonn M

2006-01-01

Over time, contemporary writing becomes part of the historical record. In medicine, it is an important learning tool, particularly for understanding the experience and context of disease and illness. Although a century has elapsed since the fictional events on a single day described in James Joyce's Ulysses, the work is still fresh with references and allusions to doctors, illnesses, and the human experience. Ulysses provides perspective on medical and social history and offers a biting commentary of continuing relevance to the doctor-patient relationship.

THREE-DIMENSIONAL FEATURES OF THE OUTER HELIOSPHERE DUE TO COUPLING BETWEEN THE INTERSTELLAR AND INTERPLANETARY MAGNETIC FIELDS. IV. SOLAR CYCLE MODEL BASED ON ULYSSES OBSERVATIONS

Energy Technology Data Exchange (ETDEWEB)

Pogorelov, N. V.; Zank, G. P. [Department of Physics, University of Alabama in Huntsville, Huntsville, AL 35899 (United States); Suess, S. T. [National Space Science and Technology Center, Huntsville, AL 35805 (United States); Borovikov, S. N. [Center for Space Plasma and Aeronomic Research, University of Alabama in Huntsville, 320 Sparkman Dr., Huntsville, AL 35805 (United States); Ebert, R. W.; McComas, D. J., E-mail: np0002@uah.edu [Southwest Research Institute, San Antonio, TX 78227 (United States)

2013-07-20

The solar cycle has a profound influence on the solar wind (SW) interaction with the local interstellar medium (LISM) on more than one timescales. Also, there are substantial differences in individual solar cycle lengths and SW behavior within them. The presence of a slow SW belt, with a variable latitudinal extent changing within each solar cycle from rather small angles to 90 Degree-Sign , separated from the fast wind that originates at coronal holes substantially affects plasma in the inner heliosheath (IHS)-the SW region between the termination shock (TS) and the heliopause (HP). The solar cycle may be the reason why the complicated flow structure is observed in the IHS by Voyager 1. In this paper, we show that a substantial decrease in the SW ram pressure observed by Ulysses between the TS crossings by Voyager 1 and 2 contributes significantly to the difference in the heliocentric distances at which these crossings occurred. The Ulysses spacecraft is the source of valuable information about the three-dimensional and time-dependent properties of the SW. Its unique fast latitudinal scans of the SW regions make it possible to create a solar cycle model based on the spacecraft in situ measurements. On the basis of our analysis of the Ulysses data over the entire life of the mission, we generated time-dependent boundary conditions at 10 AU from the Sun and applied our MHD-neutral model to perform a numerical simulation of the SW-LISM interaction. We analyzed the global variations in the interaction pattern, the excursions of the TS and the HP, and the details of the plasma and magnetic field distributions in the IHS. Numerical results are compared with Voyager data as functions of time in the spacecraft frame. We discuss solar cycle effects which may be reasons for the recent decrease in the TS particles (ions accelerated to anomalous cosmic-ray energies) flux observed by Voyager 1.

THREE-DIMENSIONAL FEATURES OF THE OUTER HELIOSPHERE DUE TO COUPLING BETWEEN THE INTERSTELLAR AND INTERPLANETARY MAGNETIC FIELDS. IV. SOLAR CYCLE MODEL BASED ON ULYSSES OBSERVATIONS

International Nuclear Information System (INIS)

Pogorelov, N. V.; Zank, G. P.; Suess, S. T.; Borovikov, S. N.; Ebert, R. W.; McComas, D. J.

2013-01-01

The solar cycle has a profound influence on the solar wind (SW) interaction with the local interstellar medium (LISM) on more than one timescales. Also, there are substantial differences in individual solar cycle lengths and SW behavior within them. The presence of a slow SW belt, with a variable latitudinal extent changing within each solar cycle from rather small angles to 90°, separated from the fast wind that originates at coronal holes substantially affects plasma in the inner heliosheath (IHS)—the SW region between the termination shock (TS) and the heliopause (HP). The solar cycle may be the reason why the complicated flow structure is observed in the IHS by Voyager 1. In this paper, we show that a substantial decrease in the SW ram pressure observed by Ulysses between the TS crossings by Voyager 1 and 2 contributes significantly to the difference in the heliocentric distances at which these crossings occurred. The Ulysses spacecraft is the source of valuable information about the three-dimensional and time-dependent properties of the SW. Its unique fast latitudinal scans of the SW regions make it possible to create a solar cycle model based on the spacecraft in situ measurements. On the basis of our analysis of the Ulysses data over the entire life of the mission, we generated time-dependent boundary conditions at 10 AU from the Sun and applied our MHD-neutral model to perform a numerical simulation of the SW-LISM interaction. We analyzed the global variations in the interaction pattern, the excursions of the TS and the HP, and the details of the plasma and magnetic field distributions in the IHS. Numerical results are compared with Voyager data as functions of time in the spacecraft frame. We discuss solar cycle effects which may be reasons for the recent decrease in the TS particles (ions accelerated to anomalous cosmic-ray energies) flux observed by Voyager 1.

Protection measurements on the Ulysse pile during its start-up

International Nuclear Information System (INIS)

Tattegrain, A.; Satge, H.

1963-01-01

The authors report measurements which aimed at verifying protection calculations made for the Ulysse atomic pile. They measured thermal, epithermal flows and the fast flow (when high enough to be measured). They also measured the gamma flow in some parts of the reactor. The authors describe the protections present on the different faces of the pile. These are made of baryte concrete and borated concrete. They indicate the detectors used to measure the different flows, and discuss the results obtained in the different channels

The Ulysses fast latitude scans: COSPIN/KET results

Directory of Open Access Journals (Sweden)

B. Heber

2003-06-01

Full Text Available Ulysses, launched in October 1990, began its second out-of-ecliptic orbit in December 1997, and its second fast latitude scan in September 2000. In contrast to the first fast latitude scan in 1994/1995, during the second fast latitude scan solar activity was close to maximum. The solar magnetic field reversed its polarity around July 2000. While the first latitude scan mainly gave a snapshot of the spatial distribution of galactic cosmic rays, the second one is dominated by temporal variations. Solar particle increases are observed at all heliographic latitudes, including events that produce >250 MeV protons and 50 MeV electrons. Using observations from the University of Chicago’s instrument on board IMP8 at Earth, we find that most solar particle events are observed at both high and low latitudes, indicating either acceleration of these particles over a broad latitude range or an efficient latitudinal transport. The latter is supported by "quiet time" variations in the MeV electron background, if interpreted as Jovian electrons. No latitudinal gradient was found for >106 MeV galactic cosmic ray protons, during the solar maximum fast latitude scan. The electron to proton ratio remains constant and has practically the same value as in the previous solar maximum. Both results indicate that drift is of minor importance. It was expected that, with the reversal of the solar magnetic field and in the declining phase of the solar cycle, this ratio should increase. This was, however, not observed, probably because the transition to the new magnetic cycle was not completely terminated within the heliosphere, as indicated by the Ulysses magnetic field and solar wind measurements. We argue that the new A<0-solar magnetic modulation epoch will establish itself once both polar coronal holes have developed.Key words. Interplanetary physics (cosmic rays; energetic particles; interplanetary magnetic fields

POSSIBLE EVIDENCE FOR A FISK-TYPE HELIOSPHERIC MAGNETIC FIELD. I. ANALYZING ULYSSES/KET ELECTRON OBSERVATIONS

International Nuclear Information System (INIS)

Sternal, O.; Heber, B.; Kopp, A.; Engelbrecht, N. E.; Burger, R. A.; Ferreira, S. E. S.; Potgieter, M. S.; Fichtner, H.; Scherer, K.

2011-01-01

The propagation of energetic charged particles in the heliospheric magnetic field is one of the fundamental problems in heliophysics. In particular, the structure of the heliospheric magnetic field remains an unsolved problem and is discussed as a controversial topic. The first successful analytic approach to the structure of the heliospheric magnetic field was the Parker field. However, the measurements of the Ulysses spacecraft at high latitudes revealed the possible need for refinements of the existing magnetic field model during solar minimum. Among other reasons, this led to the development of the Fisk field. This approach is highly debated and could not be ruled out with magnetic field measurements so far. A promising method to trace this magnetic field structure is to model the propagation of electrons in the energy range of a few MeV. Employing three-dimensional and time-dependent simulations of the propagation of energetic electrons, this work shows that the influence of a Fisk-type field on the particle transport in the heliosphere leads to characteristic variations of the electron intensities on the timescale of a solar rotation. For the first time it is shown that the Ulysses count rates of 2.5-7 MeV electrons contain the imprint of a Fisk-type heliospheric magnetic field structure. From a comparison of simulation results and the Ulysses count rates, realistic parameters for the Fisk theory are derived. Furthermore, these parameters are used to investigate the modeled relative amplitudes of protons and electrons, including the effects of drifts.

Inflight performance of the Ulysses reaction control system

Science.gov (United States)

McGarry, Andrew; Berry, William; Parker, David

1997-01-01

The Ulysses spacecraft has been exploring the heliosphere since October 1990 in a six-year polar orbit. Despite varying operational demands, the pressure-fed monopropellant hydrazine reaction control system (RCS) has experienced few problems. The observed anomalies, having minimal operational impact, include plume impingement effects, electrical power overload effects and hydrazine gas generation effects. These anomalies are presented and discussed, with emphasis on the first observation of gas in the hydrazine propellant. The relatively low gas generation rate is attributed to: the use of high purity hydrazine; the configuration of the spin-stabilized spacecraft; the extensive use of titanium alloys; and the efficiency of the thermal control of the propellant tank which maintains a temperature of 21 C.

Energetic particle measurements from the Ulysses/COSPIN/LET instrument obtained during the August/September 2005 events

International Nuclear Information System (INIS)

Malandraki, O.E.; Imperial Coll. of Science and Technology, London; National Observatory of Athens; Marsden, R.G.; Tranquille, C.; Forsyth, R.J.; Elliott, H.A.; Geranios, A.

2008-01-01

We report recent observations of energetic particles at energies 1-40 MeV/n made by the COSPIN/LET instrument onboard the Ulysses spacecraft during the period of intense solar activity in August/September 2005 during the declining phase of solar cycle 23. Ulysses, having started its climb to high southern latitudes for the third time, was located at ∝5 AU, at a helio-latitude of ∝30 degrees south. It detected the arrival of a solar wind compound stream resulting from the merging of a series of fast halo CMEs ejected from the Sun in late August and early September 2005 and their interaction with the pre-existing pattern of solar wind Stream Interaction Regions (SIRs) in the ambient medium through which they propagated. The heavy ion intensities are observed by COSPIN/LET to remain elevated for at least 20 days following the very intense X17.0/3B solar flare on 7 September and its associated very fast CME (plane of sky projected CME speed ∝2400 km s -1 ). We carry out an analysis of the composition of the particle increases observed at the location of the spacecraft. Although the composition signatures were predominantly Solar Energetic Particle (SEP)-like, after the passage of the compound stream over Ulysses, in association with a characteristic forward and reverse shock pair, the observations showed evidence of an enhanced He content. (orig.)

RTG performance on Galileo and Ulysses and Cassini test results

International Nuclear Information System (INIS)

Kelly, C. Edward; Klee, Paul M.

1997-01-01

Power output from telemetry for the two Galileo RTGs are shown from the 1989 launch to the recent Jupiter encounter. Comparisons of predicted, measured and required performance are shown. Similar comparisons are made for the RTG on the Ulysses spacecraft which completed its planned mission in 1995. Also presented are test results from small scale thermoelectric modules and full scale converters performed for the Cassini program. The Cassini mission to Saturn is scheduled for an October 1997 launch. Small scale module test results on thermoelectric couples from the qualification and flight production runs are shown. These tests have exceeded 19,000 hours are continuing to provide increased confidence in the predicted long term performance of the Cassini RTGs. Test results are presented for full scale units both ETGs (E-6, E-7) and RTGs (F-2, F-5) along with mission power predictions. F-5, fueled in 1985, served as a spare for the Galileo and Ulysses missions and plays the same role in the Cassini program. It has successfully completed all acceptance testing. The ten years storage between thermal vacuum tests is the longest ever experienced by an RTG. The data from this test are unique in providing the effects of long term low temperature storage on power output. All ETG and RTG test results to date indicate that the power requirements of the Cassini spacecraft will be met. BOM and EOM power margins of at least five percent are predicted

Gamma ray burst source locations with the Ulysses/Compton/PVO Network

International Nuclear Information System (INIS)

Cline, T.L.; Hurley, K.C.; Boer, M.; Sommer, M.; Niel, M.; Fishman, G.J.; Kouveliotou, C.; Meegan, C.A.; Paciesas, W.S.; Wilson, R.B.; Laros, J.G.; Klebesadel, R.W.

1991-01-01

The new interplanetary gamma-ray burst network will determine source fields with unprecedented accuracy. The baseline of the Ulysses mission and the locations of Pioneer-Venus Orbiter and of Mars Observer will ensure precision to a few tens of arc seconds. Combined with the event phenomenologies of the Burst and Transient Source Experiment on Compton Observatory, the source locations to be achieved with this network may provide a basic new understanding of the puzzle of gamma ray bursts

The "Ulysses syndrome": An eponym identifies a psychosomatic disorder in modern migrants.

Science.gov (United States)

Bianucci, Raffaella; Charlier, Philippe; Perciaccante, Antonio; Lippi, Donatella; Appenzeller, Otto

2017-06-01

Due to civil wars, violence and persecutions, between 2015 and 2016, more than 1.4 million people, from the Middle East and Africa, fled their counties and migrated to Europe. The vast majority of migrants, who have already experienced enormous level of stressors, are faced with dangerous, often lethal, migratory journeys. Those who survive are exposed to adaptation stressors such as different languages, isolation, lack of work opportunities, diminished social status and a sense of failure in the new countries of residence. These are stressors that go far beyond the usual adaptation stresses to new cultures and migrants experience permanent crises with an imminent risk of developing the "Ulysses syndrome". As a consequence, many individuals often develop symptoms such as irritability, nervousness, migraine, tension headache, insomnia, tiredness, fear, loss of appetite and generalized ill-defined discomfort. If left untreated these symptoms, originally described by Hofer in the 17th century, may degenerate into a severe psychosomatic disorder leading to reactive depression. Here we expand the concept of Ulysses' syndrome and illustrate new initiatives aimed at reducing the level of stressors in migrants and at promoting their successful integration in their new countries. Copyright © 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

Ulysses contracts for the doctor and for the patient.

Science.gov (United States)

Hansson, Mats G; Hakama, Matti

2010-05-01

Research subjects participating in randomised clinical trials have a right to drop out of a study without specifying any reason for this. However, leaving a trial may be contradictory to their own general interests in medical research since drop outs may lead to biased conclusions and loss of valuable medical information. We suggest in this paper that self-binding "Ulysses contracts" that are non-exploitative and based on autonomous decisions by research subjects as well as by investigating doctors should be implemented with stopping rules adjusted to the needs of different kinds of randomised clinical trials. Copyright (c) 2010 Elsevier Inc. All rights reserved.

Low-energy solar electrons and ions observed at Ulysses February-April, 1991 - The inner heliosphere as a particle reservoir

Science.gov (United States)

Roelof, E. C.; Gold, R. E.; Simnett, G. M.; Tappin, S. J.; Armstrong, T. P.; Lanzerotti, L. J.

1992-01-01

Ulysses observations at 2.5 AU of 38-315 keV electrons and 61-4752 keV ions during February-April 1991 suggest in several ways that, during periods of sustained high solar activity, the inner heliosphere serves as a 'reservoir' for low-energy solar particles. Particle increases were not associated one-to-one with large X-ray flares because of their poor magnetic connection, yet intensities in March-April remained well above their February levels. The rise phase of the particle event associated with the great flare of 2245UT March 22 lasted most of two days, while throughout the one-week decay phase, the lowest-energy ion fluxes were nearly equal at Ulysses and earth (IMP-8).

Ulysses: the effectiveness of a multidisciplinary cognitive behavioural pain management programme-an 8-year review.

Science.gov (United States)

Fullen, B M; Blake, C; Horan, S; Kelley, V; Spencer, O; Power, C K

2014-06-01

To characterise a cohort of patients with chronic pain registered to the Ulysses cognitive behavioural pain management programme (CBT-PMP) and to evaluate the effectiveness of the CBT-PMP 6 months post-discharge. A review of patients referred to the Ulysses CBT-PMP from 2002 to 2010 was undertaken. The profile of patients was established. Domains measured included pain, physical and psychological function. Relationships between these factors were explored. Clinically significant changes in outcome measures were established at the 6-month follow-up. In total 553 patients registered to the CBT-PMP, pre-post data were available for 91 % of patients and 52 % at 6 months. The majority of patients were female and aged between 40 and 50 years. Most patients had significant psychological morbidity (76 % depression, 84.5 % anxiety), moderate reports of pain [numerical rating scale, mean (SD) 6.0 (2.2)], and low levels of functional activity. At 6 months follow-up, statistically significant positive findings for physical and psychological outcome measures are supplemented by results showing their clinical significance. With regard to psychological function, a clinically significant change (depending on outcome measure) was shown between 1 in 2 and 1 in 10 patients. Improvements in physical function were lower with rates of 1 in 4 to 1 in 14 reporting significant gains. The effectiveness of the Ulysses CBT-PMP is established with measures of clinically significant change for physical and psychological outcomes contributing to the evidence for this novel approach of analysis. Future research determining benchmarks for CBT-PMP outcomes will assist clinicians in monitoring and enhancing patient's progress in clinical practice.

Pickup Protons: Comparisons using the Three-Dimensional MHD HHMS-PI model and Ulysses SWICS Measurements

Science.gov (United States)

Intriligator, Devrie S.; Detman, Thomas; Gloecker, George; Gloeckler, Christine; Dryer, Murray; Sun, Wei; Intriligator, James; Deehr, Charles

2012-01-01

We report the first comparisons of pickup proton simulation results with in situ measurements of pickup protons obtained by the SWICS instrument on Ulysses. Simulations were run using the three dimensional (3D) time-dependent Hybrid Heliospheric Modeling System with Pickup Protons (HHMS-PI). HHMS-PI is an MHD solar wind model, expanded to include the basic physics of pickup protons from neutral hydrogen that drifts into the heliosphere from the local interstellar medium. We use the same model and input data developed by Detman et al. (2011) to now investigate the pickup protons. The simulated interval of 82 days in 2003 2004, includes both quiet solar wind (SW) and also the October November 2003 solar events (the Halloween 2003 solar storms). The HHMS-PI pickup proton simulations generally agree with the SWICS measurements and the HHMS-PI simulated solar wind generally agrees with SWOOPS (also on Ulysses) measurements. Many specific features in the observations are well represented by the model. We simulated twenty specific solar events associated with the Halloween 2003 storm. We give the specific values of the solar input parameters for the HHMS-PI simulations that provide the best combined agreement in the times of arrival of the solar-generated shocks at both ACE and Ulysses. We show graphical comparisons of simulated and observed parameters, and we give quantitative measures of the agreement of simulated with observed parameters. We suggest that some of the variations in the pickup proton density during the Halloween 2003 solar events may be attributed to depletion of the inflowing local interstellar medium (LISM) neutral hydrogen (H) caused by its increased conversion to pickup protons in the immediately preceding shock.

Comparative time-series analysis of MeV electron data by Ulysses and Pioneer 10/11 in the Jovian magnetosphere

International Nuclear Information System (INIS)

Dunzlaff, P.; Kiel Univ.; Heber, B.; Kopp, A.; North-West Univ., Potchefstroom; Potgieter, M.S.

2013-01-01

The dynamics of the Jovian magnetosphere is dominated by the planet's fast rotation with a period of ∝ 10 h.Within the magnetosphere, this periodicity can in particular be seen in the temporal variation of the spectral index of MeV electrons: every ∝ 10 h the counting rates show a maximum (minimum), while the spectral index shows a minimum (maximum) known as the Jovian ''clock'' mechanism. In this study we re-analyse Ulysses and Pioneer 10/11 data and show that another periodic modulation in the MeV electrons can be identified, manifested by local maxima of the spectral index and local minima of the counting rates. For Ulysses, this modulation can be observed throughout the magnetosphere near the magnetic equator, suggesting an azimuthal asymmetric distribution of MeV electrons near the current sheet. This modulation is found to trail the ''clock'' mechanism by ∝ 3.25 h. The Pioneer 10 data, however, only show occasional evidence of the presence of these local maxima while there is no evidence of this modulation in the Pioneer 11 data. A comparison of the times of observed minor peaks and Ulysses' distance from the current sheet using a simple rigid disc model as well as the model of Khurana and Schwarzl (2005) is performed.

Chaos Theory and James Joyce's "ulysses": Leopold Bloom as a Human COMPLEX@SYSTEM^

Science.gov (United States)

Mackey, Peter Francis

1995-01-01

These four ideas apply as much to our lives as to the life of Leopold Bloom: (1) A trivial decision can wholly change a life. (2) A chance encounter can dramatically alter life's course. (3) A contingent nexus exists between consciousness and environment. (4) A structure of meaning helps us interpret life's chaos. These ideas also relate to a contemporary science called by some "chaos theory." The connection between Ulysses and chaos theory enhances our understanding of Bloom's day; it also suggests that this novel may be about the real process of life itself. The first chapter explains how Joyce's own essays and comments to friends compel attention to the links between Ulysses and chaos theory. His scientific contemporaries anticipated chaos theory, and their ideas seem to have rubbed off on him. We see this in his sense of trivial things and chance, his modernistic organizational impulses, and the contingent nature of Bloom's experience. The second chapter studies what chaos theory and Joyce's ideas tell us about "Ithaca," the episode which particularly implicates our processes of interpreting this text as well as life itself as we face their chaos. The third chapter examines Bloom's close feel for the aboriginal world, a contingency that clarifies his vulnerability to trivial changes. The fourth chapter studies how Bloom's stream of consciousness unfolds--from his chance encounters with trivial things. Beneath this stream's seeming chaos, Bloom's distinct personality endures, similar to how Joyce's schemas give Ulysses an imbedded, underlying order. The fifth chapter examines how trivial perturbations, such as Lyons' misunderstanding about "Throwaway," produce small crises for Bloom, exacerbating his seeming impotence before his lonely "fate.". The final chapter analyzes Bloom's views that fate and chance dictate his life. His views provide an opportunity to explore the implications chaos theory has for our understanding of free will and determinism. Ultimately

RTG performance on Galileo and Ulysses and Cassini test results

International Nuclear Information System (INIS)

Kelly, C.E.; Klee, P.M.

1997-01-01

Power output from telemetry for the two Galileo RTGs are shown from the 1989 launch to the recent Jupiter encounter. Comparisons of predicted, measured and required performance are shown. Similar comparisons are made for the RTG on the Ulysses spacecraft which completed its planned mission in 1995. Also presented are test results from small scale thermoelectric modules and full scale converters performed for the Cassini program. The Cassini mission to Saturn is scheduled for an October 1997 launch. Small scale module test results on thermoelectric couples from the qualification and flight production runs are shown. These tests have exceeded 19,000 hours are continuing to provide increased confidence in the predicted long term performance of the Cassini RTGs. Test results are presented for full scale units both ETGs (E-6, E-7) and RTGs (F-2, F-5) along with mission power predictions. F-5, fueled in 1985, served as a spare for the Galileo and Ulysses missions and plays the same role in the Cassini program. It has successfully completed all acceptance testing. The ten years storage between thermal vacuum tests is the longest ever experienced by an RTG. The data from this test are unique in providing the effects of long term low temperature storage on power output. All ETG and RTG test results to date indicate that the power requirements of the Cassini spacecraft will be met. BOM and EOM power margins of at least five percent are predicted. copyright 1997 American Institute of Physics

The northern edge of the band of solar wind variability: Ulysses at ∼4.5AU

International Nuclear Information System (INIS)

Gosling, J.T.; Bame, S.J.; Feldman, W.C.; McComas, D.J.; Riley, P.; Goldstein, B.E.; Neugebauer, M.

1997-01-01

Ulysses observations reveal that the northern edge of the low-latitude band of solar wind variability at ∼4.5AU was located at N30 degree in the latter part of 1996 when solar activity was at a minimum. This edge latitude is intermediate between edge latitudes found during previous encounters with the band edge along different portions of Ulysses close-quote polar orbit about the Sun. Corotating interaction regions, CIRs, near the northern edge of the band were tilted in such a manner that the forward and reverse shocks bounding the CIRs were propagating equatorward and poleward, respectively, providing definite confirmation that CIRs have opposed tilts in the opposite solar hemispheres. No shocks or coronal mass ejections, CMEs, were detected during the ∼1.5y traverse of the northern, high-latitude northern hemisphere; however, at the northern edge of the band of variability an expanding CME was observed that was driving a shock into the high-speed wind.copyright 1997 American Geophysical Union

Ulysses solar wind plasma observations at high southerly latitudes.

Science.gov (United States)

Phillips, J L; Bame, S J; Feldman, W C; Gosling, J T; Hammond, C M; McComas, D J; Goldstein, B E; Neugebauer, M; Scime, E E; Suess, S T

1995-05-19

Solar wind plasma observations made by the Ulysses spacecraft through -80.2 degrees solar latitude and continuing equatorward to -40.1 degrees are summarized. Recurrent high-speed streams and corotating interaction regions dominated at middle latitudes. The speed of the solar wind was typically 700 to 800 kilometers per second poleward of -35 degrees . Corotating reverse shocks persisted farther south than did forward shocks because of the tilt of the heliomagnetic streamer belt. Sporadic coronal mass ejections were seen as far south as -60.5 degrees . Proton temperature was higher and the electron strahl was broader at higher latitudes. The high-latitude wind contained compressional, pressure-balanced, and Alfvénic structures.

The Eyes of That Cow: Eating Animals and Theorizing Vegetarianism in James Joyce’s Ulysses

Directory of Open Access Journals (Sweden)

Peter Adkins

2017-07-01

Full Text Available At the end of the nineteenth century more than half of Ireland’s entire land surface was being used for the raising of livestock, most of which was transported through Dublin on its way to England to be slaughtered and eaten. The same period saw the development of a new social phenomena of vegetarianism amongst Ireland’s intellectuals and literary figures. This article focuses on James Joyce’s portrayal of livestock, meat and vegetarianism in Ulysses, examining how the novel engages with the politics of cattle raising, the emergence of industrialized animal slaughter and the ethics of meat eating at the turn of the twentieth century. Attending to the ways in which Joyce both historicizes and theorizes the lives of animals and the production of meat, this article places Ulysses in dialogue with recent writings on animal ethics by Jacques Derrida and J. M. Coetzee and the emergence of what is being termed “vegan studies” to suggest a vegetarian reading of Joyce’s novel.

Ulysses Observations of Tripolar Guide-Magnetic Field Perturbations Across Solar Wind Reconnection Exhausts

Science.gov (United States)

Eriksson, S.; Peng, B.; Markidis, S.; Gosling, J. T.; McComas, D. J.; Lapenta, G.; Newman, D. L.

2014-12-01

We report observations from 15 solar wind reconnection exhausts encountered along the Ulysses orbit beyond 4 AU in 1996-1999 and 2002-2005. The events, which lasted between 17 and 45 min, were found at heliospheric latitudes between -36o and 21o with one event detected as high as 58o. All events shared a common characteristic of a tripolar guide-magnetic field perturbation being detected across the observed exhausts. The signature consists of an enhanced guide field magnitude within the exhaust center and two regions of significantly depressed guide-fields adjacent to the center region. The events displayed magnetic field shear angles as low as 37o with a mean of 89o. This corresponds to a strong external guide field relative to the anti-parallel reconnecting component of the magnetic field with a mean ratio of 1.3 and a maximum ratio of 3.1. A 2-D kinetic reconnection simulation for realistic solar wind conditions reveals that tripolar guide fields form at current sheets in the presence of multiple X-lines as two magnetic islands interact with one another for such strong guide fields. The Ulysses observations are also compared with the results of a 3-D kinetic simulation of multiple flux ropes in a strong guide field.

Comparative time-series analysis of MeV electron data by Ulysses and Pioneer 10/11 in the Jovian magnetosphere

Energy Technology Data Exchange (ETDEWEB)

Dunzlaff, P. [North-West Univ., Potchefstroom (South Africa). Centre for Space Research; Kiel Univ. (Germany). Inst. fuer Experimentelle und Angewandte Physik; Heber, B. [Kiel Univ. (Germany). Inst. fuer Experimentelle und Angewandte Physik; Kopp, A. [Kiel Univ. (Germany). Inst. fuer Experimentelle und Angewandte Physik; North-West Univ., Potchefstroom (South Africa). Centre for Space Research; Potgieter, M.S. [North-West Univ., Potchefstroom (South Africa). Centre for Space Research

2013-11-01

The dynamics of the Jovian magnetosphere is dominated by the planet's fast rotation with a period of {proportional_to} 10 h.Within the magnetosphere, this periodicity can in particular be seen in the temporal variation of the spectral index of MeV electrons: every {proportional_to} 10 h the counting rates show a maximum (minimum), while the spectral index shows a minimum (maximum) known as the Jovian ''clock'' mechanism. In this study we re-analyse Ulysses and Pioneer 10/11 data and show that another periodic modulation in the MeV electrons can be identified, manifested by local maxima of the spectral index and local minima of the counting rates. For Ulysses, this modulation can be observed throughout the magnetosphere near the magnetic equator, suggesting an azimuthal asymmetric distribution of MeV electrons near the current sheet. This modulation is found to trail the ''clock'' mechanism by {proportional_to} 3.25 h. The Pioneer 10 data, however, only show occasional evidence of the presence of these local maxima while there is no evidence of this modulation in the Pioneer 11 data. A comparison of the times of observed minor peaks and Ulysses' distance from the current sheet using a simple rigid disc model as well as the model of Khurana and Schwarzl (2005) is performed.

Ulysses charged particle measurements between 1 and 5 AU from the sun.

Science.gov (United States)

Page, D E; Smith, E J; Wenzel, K P

1994-10-01

Proton fluxes obtained by two instruments carried on the ESA/NASA Ulysses spacecraft are reported for the period from launch in October 1990 till Jupiter encounter in February 1992. Proton energy ranges are 24-59, 71-99, 130-320, 320-2100 and > 2100 MeV. The Sun was very active during this period, the events of March 1991 being some of the largest of the solar cycle. The relationship between events on the Sun and the observed proton flux is discussed.

The Ulysses contract in obstetrics: a woman's choices before and during labour.

Science.gov (United States)

Burcher, Paul

2013-01-01

Women recognise that labour represents a mind-altering event that may affect their ability to make and communicate decisions and choices. For this reason, birth plans and other pre-labour directives can represent a form of Ulysses contract: an attempt to make binding choices before the sometimes overwhelming circumstances of labour. These choices need to be respected during labour, but despite the reduced decisional and communicative capacity of a labouring woman, her choices, when clear, should supersede decisions made before labour.

Gigas Meets Ulysses

Science.gov (United States)

2003-01-01

[figure removed for brevity, see original site] Released 9 July 2003Roughly halfway between the great volcanoes of Olympus Mons and Pavonis Mons, the graben (troughs) of Ulysses Fossae intersect with the furrows of Gigas (gigantic) Sulci. A clear time sequence is evident: first came the formation of the sulci terrain (to the left), which then was fractured by graben radial to Olympus Mons, followed by flooding of lava. All but the deepest graben are filled by lava in the topographic low between the two volcanic rises.Image information: VIS instrument. Latitude 11.8, Longitude 234.3 East (125.7 West). 19 meter/pixel resolution.Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time.NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.

A cylindrical current sheet over the South solar pole observed by Ulysses

Science.gov (United States)

Khabarova, Olga; Kislov, Roman; Malova, Helmi; Obridko, Vladimir

2016-04-01

We provide the first evidence for the existence of a quasi-stable cylindrical current sheet over the South solar pole as observed by Ulysses in 2006, near the solar minimum, when it reached maximal heliolatitude of 79.7 degrees at 2.4 AU. It took place inside a fast speed stream from the coronal hole, and the tube was presumably crossed rather far from the center within two degrees of heliolatitude and ~10 degrees of heliolongitude. During the spacecraft passage throughout the structure, the solar wind velocity was approximately twice as little, the solar wind density was 20 times lower than the surrounded plasma values, but the temperature was twice as large in the point closest to the pole. The interplanetary magnetic field (IMF) strongly decreased due to sharp variations in the IMF radial component (RTN) that changed its sign twice, but other components did not show changes out of usual stochastic behavior. Both the behavior of the IMF, rotation of the plasma flow direction and other features indicate the occurrence of cylindrical current sheet. We discuss its solar origin and present modeling that can explain the observations.

Magnetic topology of coronal mass ejection events out of the ecliptic: Ulysses/HI-SCALE energetic particle observations

Directory of Open Access Journals (Sweden)

O. E. Malandraki

2003-06-01

Full Text Available Solar energetic particle fluxes (Ee > 38 keV observed by the ULYSSES/HI-SCALE experiment are utilized as diagnostic tracers of the large-scale structure and topology of the Interplanetary Magnetic Field (IMF embedded within two well-identified Interplanetary Coronal Mass Ejections (ICMEs detected at 56° and 62° south heliolatitudes by ULYSSES during the solar maximum southern high-latitude pass. On the basis of the energetic solar particle observations it is concluded that: (A the high-latitude ICME magnetic structure observed in May 2000 causes a depression in the solar energetic electron intensities which can be accounted for by either a detached or an attached magnetic field topology for the ICME; (B during the traversal of the out-of-ecliptic ICME event observed in July 2000 energetic electrons injected at the Sun are channeled by the ICME and propagate freely along the ICME magnetic field lines to 62° S heliolatitude.Key words. Interplanetary physics (energetic particles; interplanetary magnetic fields

Detection of zero anisotropy at 5.2 AU during the November 1998 solar particle event: Ulysses Anisotropy Telescopes observations

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S. Dalla

Full Text Available For the first time during the mission, the Anisotropy Telescopes instrument on board the Ulysses spacecraft measured constant zero anisotropy of protons in the 1.3-2.2 MeV energy range, for a period lasting more than three days. This measurement was made during the energetic particle event taking place at Ulysses between 25 November and 15 December 1998, an event characterised by constant high proton fluxes within a region delimited by two interplanetary forward shocks, at a distance of 5.2 AU from the Sun and heliographic latitude of 17°S. We present the ATs results for this event and discuss their possible interpretation and their relevance to the issue of intercalibration of the two telescopes.

Key words: Interplanetary physics (energetic particles - Solar physics, astrophysics and astronomy (energetic particles - Space plasma physics (instruments and techniques

Ulysses' rapid crossing of the polar coronal hole boundary

International Nuclear Information System (INIS)

McComas, D.J.; Riley, P.; Gosling, J.T.; Balogh, A.; Forsyth, R.

1998-01-01

The Ulysses spacecraft crossed from the slow dense solar wind characteristic of the solar streamer belt into the fast, less dense flow from the northern polar coronal hole over a very short interval (several days) in late March 1995. The spacecraft, which was at 1.35 AU and ∼19 degree north heliographic latitude, moving northward in its orbit, remained in the fast solar wind from then through summer 1996. This boundary crossing is unique in that the combination of the spacecraft motion and rotation of the structure past the spacecraft caused Ulysses to move smoothly and completely from one regime into the other. In this study we examine this crossing in detail. The crossing is marked by a region of enhanced pressure, typical of stream interaction regions, which extends ∼2x10 7 km across. We find that the transition between the slow and fast regimes occurs on several temporal, and hence spatial, scales. On the shortest scale ( 4 km) the stream interface is a tangential discontinuity where the proton and core electron densities and ion and electron pressures all drop while the magnetic pressure jumps to maintain a rough pressure balance. The alpha to proton ratio also jumps across the stream interface to reach the comparatively constant polar hole value of ∼4.3%. On larger scales (a few x10 6 km) the proton and alpha temperatures rise to their high-speed wind values. Finally, on the largest scale (∼10 8 km) the solar wind speed ramps up from ∼400kms -1 to ∼750kms -1 , typical of polar hole flows. While it seems likely that the stream interface maps back to a sharp boundary near the Sun, the large region of increasing flow speed suggests that there is also an extended gradient in solar wind source speed close to the Sun. copyright 1998 American Geophysical Union

Coercion and pressure in psychiatry: lessons from Ulysses.

Science.gov (United States)

Widdershoven, Guy; Berghmans, Ron

2007-10-01

Coercion and pressure in mental healthcare raise moral questions. This article focuses on moral questions raised by the everyday practice of pressure and coercion in the care for the mentally ill. In view of an example from literature-the story of Ulysses and the Sirens-several ethical issues surrounding this practice of care are discussed. Care giver and patient should be able to express feelings such as frustration, fear and powerlessness, and attention must be paid to those feelings. In order to be able to evaluate the intervention, one has to be aware of the variety of goals the intervention can aim at. One also has to be aware of the variety of methods of intervention, each with its own benefits and drawbacks. Finally, an intervention requires a context of care and responsibility, along with good communication and fair treatment before, during and after the use of coercion and pressure.

Volcanic Activity on lo at the Time of the Ulysses Encounter.

Science.gov (United States)

Spencer, J R; Howell, R R; Clark, B E; Klassen, D R; O'connor, D

1992-09-11

The population of heavy ions in lo's torus is ultimately derived from lo volcanism. Groundbased infrared observations of lo between October 1991 and March 1992, contemporaneous with the 8 February 1992 Ulysses observations of the lo torus, show that volcanic thermal emission was at the low end of the normal range at all lo longitudes during this period. In particular, the dominant hot spot Loki was quiescent. Resolved images show that there were at least four hot spots on lo's Jupiter-facing hemisphere, including Loki and a long-lived spot on the leading hemisphere (Kanehekili), of comparable 3.5-micrometer brightness but higher temperature.

A Primary Source to Supplement High School History Textbooks in a Character Study of Ulysses S. Grant.

Science.gov (United States)

Beardsley, Donna A.

This paper discusses the use of General Horace Porter, President Ulysses S. Grant's personal friend and closest adviser through the latter stages of the U.S. Civil War and into Grant's presidency. During the Civil War, Porter made field observations, suggested strategy, and relayed orders among commanders. As adviser to the president, Porter wrote…

Magnetic topology of coronal mass ejection events out of the ecliptic: Ulysses/HI-SCALE energetic particle observations

Directory of Open Access Journals (Sweden)

O. E. Malandraki

Full Text Available Solar energetic particle fluxes (E_e > 38 keV observed by the ULYSSES/HI-SCALE experiment are utilized as diagnostic tracers of the large-scale structure and topology of the Interplanetary Magnetic Field (IMF embedded within two well-identified Interplanetary Coronal Mass Ejections (ICMEs detected at 56° and 62° south heliolatitudes by ULYSSES during the solar maximum southern high-latitude pass. On the basis of the energetic solar particle observations it is concluded that: (A the high-latitude ICME magnetic structure observed in May 2000 causes a depression in the solar energetic electron intensities which can be accounted for by either a detached or an attached magnetic field topology for the ICME; (B during the traversal of the out-of-ecliptic ICME event observed in July 2000 energetic electrons injected at the Sun are channeled by the ICME and propagate freely along the ICME magnetic field lines to 62° S heliolatitude.

Key words. Interplanetary physics (energetic particles; interplanetary magnetic fields

Interplanetary fast shock diagnosis with the radio receiver on Ulysses

Science.gov (United States)

Hoang, S.; Pantellini, F.; Harvey, C. C.; Lacombe, C.; Mangeney, A.; Meuer-Vernet, N.; Perche, C.; Steinberg, J.-L.; Lengyel-Frey, D.; Macdowall, R. J.

1992-01-01

The radio receiver on Ulysses records the quasi-thermal noise which allows a determination of the density and temperature of the cold (core) electrons of the solar wind. Seven interplanetary fast forward or reverse shocks are identified from the density and temperature profiles, together with the magnetic field profile from the Magnetometer experiment. Upstream of the three strongest shocks, bursts of nonthermal waves are observed at the electron plasma frequency f(peu). The more perpendicular the shock, the longer the time interval during which these upstream bursts are observed. For one of the strongest shocks we also observe two kinds of upstream electromagnetic radiation: radiation at 2 f(peu), and radiation at the downstream electron plasma frequency, which propagates into the less dense upstream regions.

Bloomsday: James Joyce's Ulysses Celebrated as Theatrical Event

Directory of Open Access Journals (Sweden)

Willmar Sauter

2009-12-01

Full Text Available James Joyce had decided that 16 June 1904 should be the one day in the life of Leopold Bloom, about which he wrote his 800 page novel Ulysses. In his book, Joyce actually followed Mr Bloom that entire day, from his getting up and having the nowadays famous kidney breakfast, to the late evening, when he had to break into his own house on 7 Eccle Street to have a drink with Stephen Dedalus, the other main figure of the novel. The centenary of that very day took, accordingly, place in 2004. I have borrowed the identity of Mr Bloom to describe some street scenes from the centennial celebrations of Bloomsday in Dublin. After this intro-ductory presentation, part two of this article will attempt to analyse Bloomsday in terms of a Theatrical Event, embedded in an unusual and striking playing culture. In a third part, Mr Bloom will once more be allowed to make some concluding comments.

The Ulysses supplement to the Granat/WATCH catalog of cosmic gamma-ray bursts

DEFF Research Database (Denmark)

Hurley, K.; Lund, Niels; Brandt, Søren Kristian

2000-01-01

We present third Interplanetary Network (IPN) localization data for 56 gamma-ray bursts in the Granat/WATCH catalog that occurred between 1990 November and 1994 September. These localizations are obtained by triangulation using various combinations of spacecraft and instruments in the IPN, which ...... consisted of Ulysses, BATSE, Pioneer Venus Orbiter, Mars Observer, WATCH, and PHEBUS. The intersections of the triangulation annuli with the WATCH error circles produce error boxes with areas as small as 16 arcmin(2), reducing the sizes of the error circles by factors of up to 800....

Status of Knowledge after Ulysses and SOHO: Session 2: Investigate the Links between the Solar Surface, Corona, and Inner Heliosphere.

Science.gov (United States)

Suess, Steven

2006-01-01

As spacecraft observations of the heliosphere have moved from exploration into studies of physical processes, we are learning about the linkages that exist between different parts of the system. The past fifteen years have led to new ideas for how the heliospheric magnetic field connects back to the Sun and to how that connection plays a role in the origin of the solar wind. A growing understanding these connections, in turn, has led to the ability to use composition, ionization state, the microscopic state of the in situ plasma, and energetic particles as tools to further analyze the linkages and the underlying physical processes. Many missions have contributed to these investigations of the heliosphere as an integrated system. Two of the most important are Ulysses and SOHO, because of the types of measurements they make, their specific orbits, and how they have worked to complement each other. I will review and summarize the status of knowledge about these linkages, with emphasis on results from the Ulysses and SOHO missions. Some of the topics will be the global heliosphere at sunspot maximum and minimum, the physics and morphology of coronal holes, the origin(s) of slow wind, SOHO-Ulysses quadrature observations, mysteries in the propagation of energetic particles, and the physics of eruptive events and their associated current sheets. These specific topics are selected because they point towards the investigations that will be carried out with Solar Orbiter (SO) and the opportunity will be used to illustrate how SO will uniquely contribute to our knowledge of the underlying physical processes.

Out-of-ecliptic quiet time MeV electron increases: Ulysses COSPIN/KET observations

International Nuclear Information System (INIS)

Heber, B.; Ferreira, S.E.S.; Potgieter, M.S.; Henize, V.K.; Moeketsi, D.M.; Fichtner, H.; Kissmann, R.

2004-01-01

The propagation of cosmic rays in turbulent magnetic fields can be studied in detail by way of in-situ measurements of energetic particles in the three-dimensional heliosphere. Measurements of 3-20 MeV electrons from 1990 to 2003 have been made by the Kiel Electron Telescope (KET) onboard the Ulysses spacecraft during varying solar conditions. In order to interpret these measurements, it is necessary to distinguish between solar, galactic and Jovian electrons and to investigate their propagation, by using sophisticated particle propagation models. The solar contribution to the MeV electron intensities can be excluded by analyzing the electron energy spectra and the nuclei time histories. The residual electron intensities can be reasonably described by modulation models taking into account galactic cosmic rays as well as Jovian electrons using different diffusion coefficients for solar minimum and maximum. The way in which the relative contribution of Jovian (point source in the ecliptic) and galactic electrons (isotropic source) varies along the Ulysses orbit is strongly dependent on the choice of these coefficients. Since the 1970's quiet time electron increases have been observed in the ecliptic and interpreted as Jovian electron increases. Therefore, the occurrence of such quiet time electron increases is an indicator for a dominant Jovian contribution to the measured MeV electron intensities. At solar minimum and maximum such events have been observed up to ∼30 deg. and ∼45 deg. These observations are crucial for a determination of the diffusion parameters. At solar maximum a more efficient latitude transport is needed to account for the electron intensity variations

Victoria Ocampo and Alfonso Reyes: Ulysses's Malady

Directory of Open Access Journals (Sweden)

Doris Meyer

2000-06-01

Full Text Available Ocampo (Argentina, 1890-1979 and Reyes (Mexico, 1889-1959 were arguably Latin America's most influential writers and cultural catalysts in the first half of the twentieth century. They met in Argentina in 1927 and their friendship and correspondence lasted until Reyes's death. Over three decades of private and public discourse, they articulated a similar vision of Latin American identity and its future potential. Because they were both internationally known—Ocampo as founder and director of the literary review SUR, and Reyes as a diplomat and intellectual leader—their ideas found resonance in the Americas and Europe. Two dramatic works they wrote before meeting, Ifigenia cruel (Reyes and La laguna de los nenúfares (Ocampo, prefigure their approach to the Latin American condition through the themes of displacement and self-renovation. Ocampo and Reyes believed that it would be the task of an educated elite to lead Latin America toward a transnational cultural synthesis and renewal. Ulysses's malady was their metaphor for the postcolonial condition that enabled Latin American minds to be open to exploration and dialogue in search of an authentic identity.

The Ulysses Reference Mission (URM); Proceedings of the EUROAVIA Design Workshop, Friedrichshafen, Federal Republic of Germany, Apr. 8-19, 1991

Science.gov (United States)

The present design symposium on the Ulysses Reference Mission (URM) provides data on the feasibility of the URM with particular attention given to reference data for Ulysses in the ecliptic plane as it passes the southern and northern pole areas of the sun. Specific issues addressed during the design workshop include the scientific objectives of the URM, the elements of the URM payload, the configuration and structural elements of the spacecraft, thermal control requirements and considerations, a system-engineering analysis, and the scientific subsystems of the URM. Also examined are the solar array and battery package, power control and distribution, technology considerations for the transmission of telemetric data, and a functional analysis of the URM on-board data-handling equipment. The description of the workshop concludes by noting that design studies are required to establish the moment of inertia and center of gravity of the URM spacecraft as well as specific mission parameters.

Lessons learned from the Galileo and Ulysses flight safety review experience

International Nuclear Information System (INIS)

Bennett, Gary L.

1998-01-01

In preparation for the launches of the Galileo and Ulysses spacecraft, a very comprehensive aerospace nuclear safety program and flight safety review were conducted. A review of this work has highlighted a number of important lessons which should be considered in the safety analysis and review of future space nuclear systems. These lessons have been grouped into six general categories: (1) establishment of the purpose, objectives and scope of the safety process; (2) establishment of charters defining the roles of the various participants; (3) provision of adequate resources; (4) provision of timely peer-reviewed information to support the safety program; (5) establishment of general ground rules for the safety review; and (6) agreement on the kinds of information to be provided from the safety review process

Former Us President Ulysses Grant’s Turkey Visit under the Shadow of San Stefano Treaty

OpenAIRE

SÖNMEZ, Ali

2013-01-01

Ottoman-US relations began at the last quarter of the 18th century and continued amicably for about a century during which the Ottomans pursued a policy to ensure the US support or at least neutrality concerning their problems with European states. During this phase of Ottoman-American relations, former US president Ulysses Simpson Grant (President between 1869-1877) visited the Ottoman capital between 1-6 March 1878. The visit coincided with gloomy days shortly after the Ottoman defeat in th...

Cassini RTG acceptance test results and RTG performance on Galileo and Ulysses

International Nuclear Information System (INIS)

Kelly, C.E.; Klee, P.M.

1997-01-01

Flight acceptance testing has been completed for the RTGs to be used on the Cassini spacecraft which is scheduled for an October 6, 1997 launch to Saturn. The acceptance test program includes vibration tests, magnetic field measurements, properties (weight and c.g.) and thermal vacuum test. This paper presents The thermal vacuum test results. Three RTGs are to be used, F-2, F-6, and F-7. F-5 is tile back-up RTG, as it was for the Galileo and Ulysses missions launched in 1989 and 1990, respectively. RTG performance measured during the thermal vacuum tests carried out at die Mound Laboratory facility met all specification requirements. Beginning of mission (BOM) and end of mission (EOM) power predictions have been made based on than tests results. BOM power is predicted to be 888 watts compared to the minimum requirement of 826 watts. Degradation models predict the EOM power after 16 years is to be 640 watts compared to a minimum requirement of 596 watts. Results of small scale module tests are also showing. The modules contain couples from the qualification and flight production runs. The tests have exceeded 28,000 hours (3.2 years) and are continuing to provide increased confidence in the predicted long term performance of the Cassini RTGs. All test results indicate that the power requirements of the Cassini spacecraft will be met. BOM and EOM power margins of over five percent are predicted. Power output from telemetry for the two Galileo RTGs are shown from the 1989 launch to the recent Jupiter encounter. Comparisons of predicted, measured and required performance are shown. Telemetry data are also shown for the RTG on the Ulysses spacecraft which completed its planned mission in 1995 and is now in the extended mission

Cassini RTG acceptance test results and RTG performance on Galileo and Ulysses

International Nuclear Information System (INIS)

Kelly, C.E.; Klee, P.M.

1997-01-01

Flight acceptance testing has been completed for the RTGs to be used on the Cassini spacecraft which is scheduled for an October 6, 1997 launch to Saturn. The acceptance test program includes vibration tests, magnetic field measurements, mass properties (weight and c.g.) and thermal vacuum test. This paper presents the thermal vacuum test results. Three RTGs are to be used, F-2, F-6, and F-7. F-5 is the backup RTG, as it was for the Galileo and Ulysses missions launched in 1989 and 1990, respectively. RTG performance measured during the thermal vacuum tests carried out at the Mound Laboratory facility met all specification requirements. Beginning of mission (BOM) and end of mission (EOM) power predictions have been made based on these tests results. BOM power is predicted to be 888 watts compared to the minimum requirement of 826 watts. Degradation models predict the EOM power after 16 years is to be 640 watts compared to a minimum requirement of 596 watts. Results of small scale module tests are also shown. The modules contain couples from the qualification and flight production runs. The tests have exceeded 28,000 hours (3.2 years) and are continuing to provide increased confidence in the predicted long term performance of the Cassini RTGs. All test results indicate that the power requirements of the Cassini spacecraft will be met. BOM and EOM power margins of over 5% are predicted. Power output from telemetry for the two Galileo RTGs are shown from the 1989 launch to the recent Jupiter encounter. Comparisons of predicted, measured and required performance are shown. Telemetry data are also shown for the RTG on the Ulysses spacecraft which completed its planned mission in 1995 and is now in the extended mission

RADIAL EVOLUTION OF SOLAR WIND TURBULENCE DURING EARTH AND ULYSSES ALIGNMENT OF 2007 AUGUST

International Nuclear Information System (INIS)

D'Amicis, R.; Bruno, R.; Pallocchia, G.; Bavassano, B.; Telloni, D.; Carbone, V.; Balogh, A.

2010-01-01

At the end of 2007 August, during the minimum of solar cycle 23, a lineup of Earth and Ulysses occurred, giving the opportunity to analyze, for the first time, the same plasma sample at different observation points, namely at 1 and 1.4 AU. In particular, it allowed us to study the radial evolution of solar wind turbulence typical of fast wind streams as proposed in a Coordinated Investigation Programme for the International Heliophysical Year. This paper describes both the macrostructure and the fluctuations at small scales of this event. We find that soon after detecting the same fast stream, the Advanced Composition Explorer (ACE) observed a change of magnetic polarity being the interplanetary current sheet located between the orbits of the two spacecraft. Moreover, we observe that the compression region formed in front of the fast stream detected at ACE's location evolves in a fast forward shock at Ulysses' orbit. On the other hand, small-scale analysis shows that turbulence is evolving. The presence of a shift of the frequency break separating the injection range from the inertial range toward lower frequencies while distance increases is a clear indication that nonlinear interactions are at work. Moreover, we observe that intermittency, as measured by the flatness factor, increases with distance. This study confirms previous analyses performed using Helios observations of the same fast wind streams at different heliocentric distances, allowing us to relax about the hypothesis of the stationarity of the source regions adopted in previous studies. Consequently, any difference noticed in the solar wind parameters would be ascribed to radial (time) evolution.

Inner Source Pickup Ions Observed by Ulysses

Science.gov (United States)

Gloeckler, G.

2016-12-01

The existence of an inner source of pickup ions close to the Sun was proposed in order to explain the unexpected discovery of C+ in the high-speed polar solar wind. Here I report on detailed analyses of the composition and the radial and latitudinal variations of inner source pickup ions measured with the Solar Wind Ion Composition Spectrometer on Ulysses from 1991 to 1998, approaching and during solar minimum. We find that the C+ intensity drops off with radial distance R as R-1.53, peaks at mid latitudes and drops to its lowest value in the ecliptic. Not only was C+ observed, but also N+, O+, Ne+, Na+, Mg+, Ar+, S+, K+, CH+, NH+, OH+, H2O+, H3O+, MgH+, HCN+, C2H4+, SO+ and many other singly-charged heavy ions and molecular ions. The measured velocity distributions of inner source pickup C+ and O+ indicate that these inner source pickup ions are most likely produced by charge exchange, photoionization and electron impact ionization of neutrals close to the Sun (within 10 to 30 solar radii). Possible causes for the unexpected latitudinal variations and the neutral source(s) producing the inner source pickup ions as well as plausible production mechanisms for inner source pickup ions will be discussed.

OBSERVATION OF UNIVERSALITY IN THE GENERALIZED SIMILARITY OF EVOLVING SOLAR WIND TURBULENCE AS SEEN BY ULYSSES

International Nuclear Information System (INIS)

Chapman, S. C.; Nicol, R. M.; Leonardis, E.; Kiyani, K.; Carbone, V.

2009-01-01

We perform statistical analysis of the fluctuating magnetic field observed in-situ by the Ulysses spacecraft, from the perspective of quantitative characterization of the evolving magnetohydrodynamic (MHD) turbulence. We focus on two successive polar passes around solar minimum which provide extended intervals of quiet, fast solar wind at a range of radial distances and latitudes: the south polar pass of 1994 and the north polar pass of 1995. Fully developed inertial range turbulence has a characteristic statistical similarity property of quantities that characterize the flow, such as the magnetic field components B k (t), so that the pth moment of fluctuations has power-law dependence on scale τ such that k (t + τ) - B k (t)| p > ∼ τ ζ(p) . We instead find a generalized similarity k (t + τ) - B k (t)| p > ∼ g(τ/τ 0 ) ζ(p) consistent with extended self-similarity; and in particular all of these Ulysses observations, from both polar passes, share the same single function g(τ/τ 0 ). If these observations are indeed characteristic of MHD turbulence evolving in-situ, then this quantifies for the first time a key aspect of the universal nature of evolving MHD turbulence in a system of finite size, with implications both for theoretical development, and for our understanding of the evolving solar wind.

The Jovian and galactic electrons in the heliosphere as seen by the KET experiment on board the spacecraft named ULYSSE

International Nuclear Information System (INIS)

Rastoin, Cecile

1995-01-01

The KET electron telescope onboard the Ulysse spacecraft flawlessly provides measurements of electrons, protons and alphas of energies above some MeV. This present work focuses on the electron data analysis and interpretation from the Ulysse's launch in 90 to the beginning of 95. The first stage of the odyssey was the Jovian encounter in February 92. The MeV electrons are here used as markers of the magnetic field global structure. We specially study the complex and highly dynamic outer magnetosphere. With reference of previous fly-by, the KET observations permit to characterize the 10-hour modulation of the Jovian electron flux and spectrum and suggest a mechanism involving the rotation of the north low-latitude polar cap. The boundary layers are seen as thick regions with transitions from magnetosheath to magnetospheric particle populations and field properties. The electron anisotropy and flux discontinuities are investigated with support of field data and provide the first evidence of magnetic reconnection occurring around the Jovian magnetopause. Taking advantage of the gravity assistance of the giant planet, Ulysse dipped towards the south heliospheric regions. Along its trajectory KET has detected Jovian electrons in interplanetary space. The first type of events is non-diffusive, with rapid increases discovered by KET at less than 1 AU from the magnetosphere: Jovian electrons have probably escaped through reconnection process which preserves their spectrum modulation and anisotropy characteristics. The events of second category are diffusive, observed since launch up to 30 degrees south. This work highlights the roles of interplanetary shocks and of the heliospheric current sheet in the propagation. A 3D transport model including adiabatic deceleration is presented here and accounts for the Jovian electron flux detected along the Ulysse's trajectory. New estimates of the 3D diffusion coefficients are performed for MeV electrons: K(perpendicular) = 8 * 10

Looking at Animals without Seeing Them: Havelock Ellis in the “Circe” Episode of Ulysses

Directory of Open Access Journals (Sweden)

Ronan Crowley

2017-09-01

Full Text Available Taking wing from Joyce’s reading of Havelock Ellis’s Studies in the Psychology of Sex, in which the Irish writer found an account of cross-species sexual contact, this essay explores Leopold Bloom’s animal metamorphosis in the “Circe” episode of Ulysses. It argues that this encounter with the nonhuman animal is subordinated to the cause of working through barriers of human difference. In the process, the animal that enables this reconciliation disappears. Unable to represent animal interiority, “Circe” settles for merely probing their interiors.

Indication, from Pioneer 10/11, Galileo, and Ulysses Data, of an Apparent Anomalous, Weak, Long-Range Acceleration

International Nuclear Information System (INIS)

Anderson, J.D.; Lau, E.L.; Turyshev, S.G.; Laing, P.A.; Liu, A.S.; Nieto, M.M.

1998-01-01

Radio metric data from the Pioneer 10/11, Galileo, and Ulysses spacecraft indicate an apparent anomalous, constant, acceleration acting on the spacecraft with a magnitude ∼8.5x10 -8 cm/s 2 , directed towards the Sun. Two independent codes and physical strategies have been used to analyze the data. A number of potential causes have been ruled out. We discuss future kinematic tests and possible origins of the signal. copyright 1998 The American Physical Society

An Overview of Energetic Particle Measurements in the Jovian Magnetosphere with the EPAC Sensor on Ulysses.

Science.gov (United States)

Keppler, E; Blake, J B; Fränz, M; Korth, A; Krupp, N; Quenby, J J; Witte, M; Woch, J

1992-09-11

Observations of ions and electrons of probable Jovian origin upstream of Jupiter were observed after a corotating interplanetary particle event. During the passage of Ulysses through the Jovian bow shock, magnetopause, and outer magnetosphere, the fluxes of energetic particles were surprisingly low. During the passage through the "middle magnetosphere," corotating fluxes were observed within the current sheet near the jovimagnetic equato. During the outbound pass, fluxes were variably directed; in the later part of the flyby, they were probably related to high-latitude phenomena.

Ulysses Observations of the Magnetic Connectivity between CMEs and the Sun

Science.gov (United States)

Riley, Pete; Gosling, J. T.; Crooker, N. U.

2004-01-01

We have investigated the magnetic connectivity of coronal mass ejections (CMEs) to the Sun using Ulysses observations of suprathermal electrons at various distances between 1 AU and 5.2 AU. Drawing on ideas concerning the eruption and evolution of CMEs, we had anticipated that there might be a tendency for CMEs to contain progressively more open field lines, as reconnection back at the Sun either opened or completely disconnected previously closed field lines threading the CMEs. Our results, however, did not yield any discernible trend. By combining the potential contribution of CMEs to the heliospheric flux with the observed build-up of flux during the course of the solar cycle we also derive a lower limit for the reconnection rate of CMEs that is sufficient to avoid the "flux catastrophe" paradox. This rate is well below our threshold of detectability.

Gamma-Ray Burst Arrival Time Localizations: Simultaneous Observations by Pioneer Venus Orbiter, Compton Gamma-Ray Observatory, and Ulysses

International Nuclear Information System (INIS)

Laros, J.G.; Hurley, K.C.; Fenimore, E.E.; Klebesadel, R.W.; Briggs, M.S.; Kouveliotou, C.; McCollough, M.L.; Fishman, G.J.; Meegan, C.A.; Cline, T.L.; Boer, M.; Niel, M.

1998-01-01

Between the Compton Gamma Ray Observatory (CGRO) launch in 1991 April and the Pioneer Venus Orbiter (PVO) demise in 1992 October, concurrent coverage by CGRO, PVO, and Ulysses was obtained for several hundred gamma-ray bursts (GRBs). Although most of these were below the PVO and Ulysses thresholds, 37 were positively detected by all three spacecraft, with data quality adequate for quantitative localization analysis. All were localized independently to ∼2 degree accuracy by the CGRO Burst and Transient Source Experiment (BATSE), and three were also localized by COMPTEL. We computed arrival-time error boxes, whose larger dimensions range from about 2' to several degrees and whose smaller dimensions are in the arcminute range. Twelve have areas less than 10 arcmin 2 , and only four have areas greater than 1 deg 2 . The area of the smallest box is 0.44 arcmin 2 . We find that the overall BATSE localization accuracy for these events is consistent with the most recent stated uncertainties. This work indicates that the ROSAT soft X-ray source found within a preliminary IPN error box for GB920501 (Trig 1576) (Hurley et al.) is less likely to be the GRB counterpart than previously reported. copyright copyright 1998. The American Astronomical Society

(abstract) ARGOS: a System to Monitor Ulysses Nutation and Thruster Firings from Variations of the Spacecraft Radio Signal

Science.gov (United States)

McElrath, T. P.; Cangahuala, L. A.; Miller, K. J.; Stravert, L. R.; Garcia-Perez, Raul

1995-01-01

Ulysses is a spin-stabilized spacecraft that experienced significant nutation after its launch in October 1990. This was due to the Sun-spacecraft-Earth geometry, and a study of the phenomenon predicted that the nutation would again be a problem during 1994-95. The difficulty of obtaining nutation estimates in real time from the spacecraft telemetry forced the ESA/NASA Ulysses Team to explore alternative information sources. The work performed by the ESA Operations Team provided a model for a system that uses the radio signal strength measurements to monitor the spacecraft dynamics. These measurements (referred to as AGC) are provided once per second by the tracking stations of the DSN. The system was named ARGOS (Attitude Reckoning from Ground Observable Signals) after the ever-vigilant, hundred-eyed giant of Greek Mythology. The ARGOS design also included Doppler processing, because Doppler shifts indicate thruster firings commanded by the active nutation control carried out onboard the spacecraft. While there is some visibility into thruster activity from telemetry, careful processing of the high-sample-rate Doppler data provides an accurate means of detecting the presence and time of thruster firings. DSN Doppler measurements are available at a ten-per-second rate in the same tracking data block as the AGC data.

Empirical models of the Solar Wind : Extrapolations from the Helios & Ulysses observations back to the corona

Science.gov (United States)

Maksimovic, M.; Zaslavsky, A.

2017-12-01

We will present extrapolation of the HELIOS & Ulysses proton density, temperature & bulk velocities back to the corona. Using simple mass flux conservations we show a very good agreement between these extrapolations and the current state knowledge of these parameters in the corona, based on SOHO mesurements. These simple extrapolations could potentially be very useful for the science planning of both the Parker Solar Probe and Solar Orbiter missions. Finally will also present some modelling considerations, based on simple energy balance equations which arise from these empirical observationnal models.

[Emigration in hard conditions: the Immigrant Syndrome with chronic and multiple stress (Ulysses' Syndrome)].

Science.gov (United States)

Achotegui, Joseba

2005-01-01

During the latest years, immigrant populations have been living in very hard conditions. To million people, migration is becoming a process with a high level of stress surpassing the human being capacity of adaptation. This people are prone to suffer the Immigrant Syndrome with chronic and multiple stress and the so called Ulysses Syndrome, what is becoming a serious health problem in the countries that receive the immigrants. This situation is the by-product of the unjust globalization and of the worsening of the living and health conditions of those undergoing such a displacement. In this article, the author postulates a relationship between the high level of stress suffered by the immigrants and their presentation of psychopathological symptoms.

Ulysses arrangements in psychiatric treatment: towards proposals for their use based on 'sharing' legal capacity.

Science.gov (United States)

Bielby, Phil

2014-06-01

A 'Ulysses arrangement' (UA) is an agreement where a patient may arrange for psychiatric treatment or non-treatment to occur at a later stage when she expects to change her mind. In this article, I focus on 'competence-insensitive' UAs, which raise the question of the permissibility of overriding the patient's subsequent decisionally competent change of mind on the authority of the patient's own prior agreement. In "The Ethical Justification for Ulysses Arrangements", I consider sceptical and supportive arguments concerning competence-insensitive UAs, and argue that there are compelling reasons to give such UAs serious consideration. In "Decisional Competence and Legal Capacity in UAs", I examine the nature of decisional competence and legal capacity as they arise in UAs, an issue neglected by previous research. Using the distinctions which emerge, I then identify the legal structure of a competence-insensitive UA in terms of the types of legal capacity it embodies and go on to explain how types of legal capacity might be shared between the patient and a trusted other to offer support to the patient in the creation and implementation of a competence-insensitive UA. This is significant because it suggests possibilities for building patient support mechanisms into models of legal UAs, which has not addressed in the literature to date. Drawing on this, in "Using Insights from the Competence/Capacity Distinction to Enhance Patient Support in UAs", I offer two possible models to operationalize competence-insensitive UAs in law that allow for varying degrees of patient support through the involvement of a trusted other. Finally, I outline some potential obstacles implementing these models would face and highlight areas for further research.

Correlations decrease with propagation of spiking activity in the mouse barrel cortex

Directory of Open Access Journals (Sweden)

Gayathri Nattar Ranganathan

2011-05-01

Full Text Available Propagation of suprathreshold spiking activity through neuronal populations is important for the function of the central nervous system. Neural correlations have an impact on cortical function particularly on the signaling of information and propagation of spiking activity. Therefore we measured the change in correlations as suprathreshold spiking activity propagated between recurrent neuronal networks of the mammalian cerebral cortex. Using optical methods we recorded spiking activity from large samples of neurons from two neural populations simultaneously. The results indicate that correlations decreased as spiking activity propagated from layer 4 to layer 2/3 in the rodent barrel cortex.

Management experience of an international venture in space The Ulysses mission

Science.gov (United States)

Yoshida, Ronald Y.; Meeks, Willis G.

1986-01-01

The management of the Ulysses project, a probe which will fly a solar polar orbit, is described. The 5-yr mission will feature a flyby of Jupiter to deflect the spacecraft into a high-inclination orbit. Data on the solar corona, solar wind, the sun-wind interface, the heliospheric magnetic field, solar and nonsolar cosmic rays, etc., will be gathered as a function of the solar latitude. NASA will track and control the probe with the Deep Space Network. JPL provides project management for NASA while the Directorate of Scientific Programs performs ESA management functions. The DOE will provide a radioisotope thermoelectric generator while NASA and ESA each supply half the scientific payload. A NASA-ESA Joint Working Group meets about twice per year to monitor the project and discuss the technical and scientific requirements. Safety issues and measures which are being addressed due to the presence of the Pu-238 heat source for the RTG are discussed.

Ulysses Radio Occultation Observations of the lo Plasma Torus During the Jupiter Encounter.

Science.gov (United States)

Bird, M K; Asmar, S W; Brenkle, J P; Edenhofer, P; Funke, O; Pätzold, M; Volland, H

1992-09-11

Radio signals from Ulysses were used to probe the lo plasma torus (IPT) shortly after the spacecraft's closest approach to Jupiter. The frequencies of the two downlinks at S-band (2.3 gigahertz) and X-band (8.4 gigahertz) were recorded, differenced, and integrated in order to derive the columnar electron density of the IPT. The measurements agree qualitatively with contemporary models of the IPT based on Voyager data, but significant differences are apparent as well. The overall level of the IPT electron density is approximately the same as the prediction, implying that the amount of gas (or plasma) injected from lo is similar to that observed during the Voyager era. On the other hand, the IPT seems to be less extended out of the centrifugal equator, implying a smaller plasma temperature than predicted.

Interagency Nuclear Safety Review Panel Power System Subpanel review for the Ulysses mission

International Nuclear Information System (INIS)

McCulloch, W.H.

1991-01-01

As part of the Interagency Nuclear Safety Review Panel's assessment of the nuclear safety of NASA's Ulysses Mission to investigate properties of the sun, the Power System Subpanel has reviewed the safety analyses and risk evaluations done for the General Purpose Heat Source-Radioisotope Thermoelectric Generator which provides on-board electrical power for the spacecraft. This paper summarizes the activities and results of that review. In general, the approach taken in the primary analysis, executed by the General Electric Company under contract to the Department of Energy, and the resulting conclusions were confirmed by the review. However, the Subpanel took some exceptions and modified the calculations accordingly, producing an independent evaluation of potential releases of radioactive fuel in launch and reentry accidents. Some of the more important of these exceptions are described briefly

Occurrence of high-beta superthermal plasma events in the close environment of Jupiter's bow shock as observed by Ulysses

International Nuclear Information System (INIS)

Marhavilas, P. K.; Sarris, E. T.; Anagnostopoulos, G. C.

2011-01-01

The ratio of the plasma pressure to the magnetic field pressure (or of their energy densities) which is known as the plasma parameter 'beta'(β) has important implications to the propagation of energetic particles and the interaction of the solar wind with planetary magnetospheres. Although in the scientific literature the contribution of the superthermal particles to the plasma pressure is generally assumed negligible, we deduced, by analyzing energetic particles and magnetic field measurements recorded by the Ulysses spacecraft, that in a series of events, the energy density contained in the superthermal tail of the particle distribution is comparable to or even higher than the energy density of the magnetic field, creating conditions of high-beta plasma. More explicitly, in this paper we analyze Ulysses/HI-SCALE measurements of the energy density ratio (parameter β ep ) of the energetic ions'(20 keV to ∼5 MeV) to the magnetic field's in order to find occurrences of high-beta (β ep >1) superthermal plasma conditions in the environment of the Jovian magnetosphere, which is an interesting plasma laboratory and an important source of emissions in our solar system. In particular, we examine high-beta ion events close to Jupiter's bow shock, which are produced by two processes: (a) bow shock ion acceleration and (b) ion leakage from the magnetosphere.

Listing of 502 Times When the Ulysses Magnetic Fields Instrument Observed Waves Due to Newborn Interstellar Pickup Protons

International Nuclear Information System (INIS)

Cannon, Bradford E.; Smith, Charles W.; Isenberg, Philip A.; Vasquez, Bernard J.; Joyce, Colin J.; Murphy, Neil; Nuno, Raquel G.

2017-01-01

In two earlier publications we analyzed 502 intervals of magnetic waves excited by newborn interstellar pickup protons that were observed by the Ulysses spacecraft. Due to the considerable effort required in identifying these events, we provide a list of the times for the 502 wave event intervals previously identified. In the process, we provide a brief description of how the waves were found and what their properties are. We also remind the reader of the conditions that permit the waves to reach observable levels and explain why the waves are not seen more often.

Listing of 502 Times When the Ulysses Magnetic Fields Instrument Observed Waves Due to Newborn Interstellar Pickup Protons

Energy Technology Data Exchange (ETDEWEB)

Cannon, Bradford E. [Physics Department, Florida State University, Tallahassee, Florida (United States); Smith, Charles W.; Isenberg, Philip A.; Vasquez, Bernard J.; Joyce, Colin J. [Physics Department and Space Science Center, Institute for the Study of Earth, Oceans, and Space, University of New Hampshire, Durham, New Hampshire (United States); Murphy, Neil [Jet Propulsion Laboratory, Mail Stop 180-600, 4800 Oak Grove Drive, Pasadena, California (United States); Nuno, Raquel G., E-mail: bc13h@my.fsu.edu, E-mail: Charles.Smith@unh.edu, E-mail: Phil.Isenberg@unh.edu, E-mail: Bernie.Vasquez@unh.edu, E-mail: Colin.Joyce@unh.edu, E-mail: Neil.Murphy@jpl.nasa.gov, E-mail: rgnuno@ucla.edu [Department of Earth, Planetary, and Space Sciences, University of California, Los Angeles, Los Angeles, CA (United States)

2017-05-01

In two earlier publications we analyzed 502 intervals of magnetic waves excited by newborn interstellar pickup protons that were observed by the Ulysses spacecraft. Due to the considerable effort required in identifying these events, we provide a list of the times for the 502 wave event intervals previously identified. In the process, we provide a brief description of how the waves were found and what their properties are. We also remind the reader of the conditions that permit the waves to reach observable levels and explain why the waves are not seen more often.

Deliberated opinion of the Environment Authority concerning the dismantling of the Ulysse reactor (CEA Saclay)

International Nuclear Information System (INIS)

2010-01-01

As the Ulysse reactor of Saclay is about to be dismantled, this report discusses the content of a request made by the CEA to definitely stop and dismantle this reactor. After having recalled the origin of this dismantling project and its regulatory framework, it describes the actual works which are planned, and outlines the main challenges to be faced. It discusses the content of the environmental report or impact study, notably the analysis of the initial condition, the analysis of direct and indirect effects of the project on the environment and health, and of the envisaged measures (waste management, liquid and gaseous effluent management, risk management, radiological exposure of workers in charge of this dismantling, and transports). Recommendations are formulated for a rewriting of the provided documents

Encounter of the Ulysses Spacecraft with the Ion Tail of Comet McNaught

Science.gov (United States)

Neugebauer, M.; Gloeckler, G.; Gosling, J. T.; Rees, A.; Skoug, R.; Goldstein, B. E.; Armstrong, T. P.; Combi, M. R.; Makinen, T.; McComas, D. J.;

ULYSSES OBSERVATIONS OF THE MAGNETIC CONNECTIVITY BETWEEN CORONAL, MASS EJECTIONS AND THE SUN

Science.gov (United States)

Riley, Pete; Goslin, J. T.; Crooker, . U.

2004-01-01

We have investigated the magnetic connectivity of coronal mass ejections (CMEs) to the Sun using Ulysses observations of suprathermal electrons at various distances between 1 and 5.2 AU. Drawing on ideas concerning the eruption and evolution of CMEs, we had anticipated that there might be a tendency for CMEs to contain progressively more open field lines, as reconnection back at the Sun either opened or completely disconnected previously closed field lines threading the CMEs. Our results, however, did not yield any discernible trend. By combining the potential contribution of CMEs to the heliospheric flux with the observed buildup of flux during the course of the solar cycle, we also derive a lower limit for the reconnection rate of CMEs that is sufficient to avoid the "flux catastrophe" paradox. This rate is well below our threshold of detectability. Subject headings: solar wind - Sun: activity - Sun: corona - Sun: coronal mass ejections (CMEs) - On-line material: color figure Sun: magnetic fields

Study of the precision of the gamma-ray burst source locations obtained with the Ulysses/PVO/CGRO network

International Nuclear Information System (INIS)

Cline, T.L.; Hurley, K.C.; Sommer, M.; Boer, M.; Niel, M.; Fishman, G.; Kouveliotou, C.; Meegan, C.; Paciesas, W.S.; Wilson, R.B.; Laros, J.G.; Klebesadel, R.W.

1994-01-01

The interplanetary gamma-ray burst network of the Ulysses, Compton-GRO, and Pioneer-Venus Orbiter missions has made source localizations with fractional-arc-minute precision for a number of events, and with auxiliary data, will provide useful annular-segment loci for many more. These studies have, thus far, yielded one possible counterpart, a Rosat x-ray association with the 92 May 1 burst. Similar to the historic 1978 November 19 burst/Einstein association, this possibility gives hope that network studies will provide a fundamental source clue for 'classical' bursts, just as a second supernova remnant in a network-defined source field has done for sgr events

The Influence of Pickup Protons, from Interstellar Neutral Hydrogen, on the Propagation of Interplanetary Shocks from the Halloween 2003 Solar Events to ACE and Ulysses: A 3-D MHD Modeling Study

Science.gov (United States)

Detman, T. R.; Intriligator, D. S.; Dryer, M.; Sun, W.; Deehr, C. S.; Intriligator, J.

2012-01-01

We describe our 3-D, time ]dependent, MHD solar wind model that we recently modified to include the physics of pickup protons from interstellar neutral hydrogen. The model has a time-dependent lower boundary condition, at 0.1 AU, that is driven by source surface map files through an empirical interface module. We describe the empirical interface and its parameter tuning to maximize model agreement with background (quiet) solar wind observations at ACE. We then give results of a simulation study of the famous Halloween 2003 series of solar events. We began with shock inputs from the Fearless Forecast real ]time shock arrival prediction study, and then we iteratively adjusted input shock speeds to obtain agreement between observed and simulated shock arrival times at ACE. We then extended the model grid to 5.5 AU and compared those simulation results with Ulysses observations at 5.2 AU. Next we undertook the more difficult tuning of shock speeds and locations to get matching shock arrival times at both ACE and Ulysses. Then we ran this last case again with neutral hydrogen density set to zero, to identify the effect of pickup ions. We show that the speed of interplanetary shocks propagating from the Sun to Ulysses is reduced by the effects of pickup protons. We plan to make further improvements to the model as we continue our benchmarking process to 10 AU, comparing our results with Cassini observations, and eventually on to 100 AU, comparing our results with Voyager 1 and 2 observations.

Potential health risks from postulated accidents involving the Pu-238 RTG on the Ulysses solar exploration mission

International Nuclear Information System (INIS)

Goldman, M.; Nelson, R.C.; Bollinger, L.; Hoover, M.D.; Templeton, W.; Anspaugh, L.

1991-01-01

Potential radiation impacts from launch of the Ulysses solar exploration experiment were evaluated using eight postulated accident scenarios. Lifetime individual dose estimates rarely exceeded 1 mrem. Most of the potential health effects would come from inhalation exposures immediately after an accident, rather than from ingestion of contaminated food or water, or from inhalation of resuspended plutonium from contaminated ground. For local Florida accidents (that is, during the first minute after launch), an average source term accident was estimated to cause a total added cancer risk of up to 0.2 deaths. For accidents at later times after launch, a worldwide cancer risk of up to three cases was calculated (with a four in a million probability). Upper bound estimates were calculated to be about 10 times higher

Decreased Left Putamen and Thalamus Volume Correlates with Delusions in First-Episode Schizophrenia Patients

Directory of Open Access Journals (Sweden)

Xiaojun Huang

2017-11-01

Full Text Available BackgroundDelusional thinking is one of the hallmark symptoms of schizophrenia. However, the underlying neural substrate for delusions in schizophrenia remains unknown. In an attempt to further our understanding of the neural basis of delusions, we explored gray matter deficits and their clinical associations in first-episode schizophrenia patients with and without delusions.MethodsTwenty-four first-episode schizophrenia patients with delusions and 18 without delusions as well as 26 healthy controls (HC underwent clinical assessment and whole-brain structural imaging which were acquired a 3.0 T scanner. Voxel-based morphometry was used to explore inter-group differences in gray matter volume using analysis of covariance, and Spearman correlation coefficients (rho between the Scale for the Assessment of Positive Symptoms (SAPS-delusion scores and mean regional brain volumes was obtained.ResultsPatients with delusions showed decreased brain gray matter volumes in the left putamen, thalamus, and caudate regions compared with HC. Patients with delusions also showed decreased regional volume in the left putamen and thalamus compared with patients without delusions. SAPS-delusion scores were negatively correlated with the gray matter volumes of the left putamen and thalamus.DiscussionLeft putamen and thalamus volume loss may be biological correlates of delusions in schizophrenia.

MODELING THE SOLAR WIND AT THE ULYSSES , VOYAGER , AND NEW HORIZONS SPACECRAFT

Energy Technology Data Exchange (ETDEWEB)

Kim, T. K.; Pogorelov, N. V.; Zank, G. P. [Center for Space Plasma and Aeronomic Research, University of Alabama in Huntsville, Huntsville, AL 35805 (United States); Elliott, H. A.; McComas, D. J. [Southwest Research Institute, San Antonio, TX 78238 (United States)

2016-11-20

The outer heliosphere is a dynamic region shaped largely by the interaction between the solar wind and the interstellar medium. While interplanetary magnetic field and plasma observations by the Voyager spacecraft have significantly improved our understanding of this vast region, modeling the outer heliosphere still remains a challenge. We simulate the three-dimensional, time-dependent solar wind flow from 1 to 80 astronomical units (au), where the solar wind is assumed to be supersonic, using a two-fluid model in which protons and interstellar neutral hydrogen atoms are treated as separate fluids. We use 1 day averages of the solar wind parameters from the OMNI data set as inner boundary conditions to reproduce time-dependent effects in a simplified manner which involves interpolation in both space and time. Our model generally agrees with Ulysses data in the inner heliosphere and Voyager data in the outer heliosphere. Ultimately, we present the model solar wind parameters extracted along the trajectory of the New Horizons spacecraft. We compare our results with in situ plasma data taken between 11 and 33 au and at the closest approach to Pluto on 2015 July 14.

Modeling the Solar Wind at the Ulysses, Voyager, and New Horizons Spacecraft

Science.gov (United States)

Kim, T. K.; Pogorelov, N. V.; Zank, G. P.; Elliott, H. A.; McComas, D. J.

2016-11-01

The outer heliosphere is a dynamic region shaped largely by the interaction between the solar wind and the interstellar medium. While interplanetary magnetic field and plasma observations by the Voyager spacecraft have significantly improved our understanding of this vast region, modeling the outer heliosphere still remains a challenge. We simulate the three-dimensional, time-dependent solar wind flow from 1 to 80 astronomical units (au), where the solar wind is assumed to be supersonic, using a two-fluid model in which protons and interstellar neutral hydrogen atoms are treated as separate fluids. We use 1 day averages of the solar wind parameters from the OMNI data set as inner boundary conditions to reproduce time-dependent effects in a simplified manner which involves interpolation in both space and time. Our model generally agrees with Ulysses data in the inner heliosphere and Voyager data in the outer heliosphere. Ultimately, we present the model solar wind parameters extracted along the trajectory of the New Horizons spacecraft. We compare our results with in situ plasma data taken between 11 and 33 au and at the closest approach to Pluto on 2015 July 14.

MODELING THE SOLAR WIND AT THE ULYSSES , VOYAGER , AND NEW HORIZONS SPACECRAFT

International Nuclear Information System (INIS)

Kim, T. K.; Pogorelov, N. V.; Zank, G. P.; Elliott, H. A.; McComas, D. J.

2016-01-01

The outer heliosphere is a dynamic region shaped largely by the interaction between the solar wind and the interstellar medium. While interplanetary magnetic field and plasma observations by the Voyager spacecraft have significantly improved our understanding of this vast region, modeling the outer heliosphere still remains a challenge. We simulate the three-dimensional, time-dependent solar wind flow from 1 to 80 astronomical units (au), where the solar wind is assumed to be supersonic, using a two-fluid model in which protons and interstellar neutral hydrogen atoms are treated as separate fluids. We use 1 day averages of the solar wind parameters from the OMNI data set as inner boundary conditions to reproduce time-dependent effects in a simplified manner which involves interpolation in both space and time. Our model generally agrees with Ulysses data in the inner heliosphere and Voyager data in the outer heliosphere. Ultimately, we present the model solar wind parameters extracted along the trajectory of the New Horizons spacecraft. We compare our results with in situ plasma data taken between 11 and 33 au and at the closest approach to Pluto on 2015 July 14.

Preliminary analysis of a CME observed by SOHO and Ulysses Experiments

Science.gov (United States)

Bemporad, A.; Poletto, G.; Romoli, M.; Suess, S. T.

2003-01-01

Over the last week of November 2002 SOHO/LASCO observed several Coronal Mass Ejections, most of which occurring in the NW quadrant. At that time SOHO/UVCS was involved in a SOHO-Sun-Ulysses quadrature campaign, making observations off the west limb of the Sun, at a northern latitude of 27 deg. Here we focus on data taken at 1.7 solar radii, over a time interval of approx. 7 hours, on 26/27 November 2002, when a large streamer disruption was imaged by LASCO C2 and C3 coronagraphs. UVCS spectra revealed the presence of lines from both high and low ionization ions, such as C III, O VI, Si VIII, IX, and XII, Fe X and XVIII, which brighten at different times, with a different time scale and at different positions and are apparently related to different phenomena. In particular, the intensity increase and fast disappearance of the C III 977 Angstrom line represents the passage through the UVCS slit of cold material released in a jet imaged by EIT in the He II 304 Angstrom line. The persistent presence of the Fe XVIII 974 Angstrom line is not easily related to any special feature crossing the UVCS slit. We suggest to interpret this behavior in terms of the reconnection events which lead to the formation of loops observed in the EIT He II 304 Angstrom line.

Decreased RECQL5 correlated with disease progression of osteosarcoma

International Nuclear Information System (INIS)

Wu, Junlong; Zhi, Liqiang; Dai, Xin; Cai, Qingchun; Ma, Wei

2015-01-01

Human RecQ helicase family, consisting of RECQL, RECQL4, RECQL5, BLM and WRN, has critical roles in genetic stability and tumorigenesis. Although RECQL5 has been reported to correlate with the susceptibility to malignances including osteosarcoma, the specific effect on tumor genesis and progression is not yet clarified. Here we focused on the relationship between RECQL5 expression and osteosarcoma disease progression, and further investigated the function of RECQL5 on MG-63 cell proliferation and apoptosis. By immunohistochemical analysis, qRT-PCR and western blot, we found that RECQL5 expression was downregulated in osteosarcoma tissues and cells. Patients with advanced tumor stage and low grade expressed lower RECQL5. To construct a stable RECQL5 overexpression osteosarcoma cell line (MG-63-RECQL5), RECQL5 gene was inserted into the human AAVS1 safe harbor by CRISPR/Cas9 system. The overexpression of RECQL5 was verified by qRT-PCR and western blot. Cell proliferation, cell cycle and apoptosis assay revealed that RECQL5 overexpression inhibited proliferation, induced G1-phase arrest and promoted apoptosis in MG-63 cells. Collectively, our results suggested RECQL5 as a tumor suppressor in osteosarcoma and may be a potential therapeutic target for osteosarcoma treatment. - Highlights: • The expression of RECQL5 was downregulated in osteosarcoma tissues and cells. • Decreased RECQL5 correlated with osteosarcoma Enneking surgical classification. • We constructed a stable RECQL5 overexpression cell line by CRISPR/Cas9 system. • RECQL5 overexpression inhibited proliferation of MG-63 cells. • RECQL5 overexpression promoted apoptosis of MG-63 cells.

Decreased RECQL5 correlated with disease progression of osteosarcoma

Energy Technology Data Exchange (ETDEWEB)

Wu, Junlong; Zhi, Liqiang; Dai, Xin; Cai, Qingchun; Ma, Wei, E-mail: doctormawei@163.com

2015-11-27

Human RecQ helicase family, consisting of RECQL, RECQL4, RECQL5, BLM and WRN, has critical roles in genetic stability and tumorigenesis. Although RECQL5 has been reported to correlate with the susceptibility to malignances including osteosarcoma, the specific effect on tumor genesis and progression is not yet clarified. Here we focused on the relationship between RECQL5 expression and osteosarcoma disease progression, and further investigated the function of RECQL5 on MG-63 cell proliferation and apoptosis. By immunohistochemical analysis, qRT-PCR and western blot, we found that RECQL5 expression was downregulated in osteosarcoma tissues and cells. Patients with advanced tumor stage and low grade expressed lower RECQL5. To construct a stable RECQL5 overexpression osteosarcoma cell line (MG-63-RECQL5), RECQL5 gene was inserted into the human AAVS1 safe harbor by CRISPR/Cas9 system. The overexpression of RECQL5 was verified by qRT-PCR and western blot. Cell proliferation, cell cycle and apoptosis assay revealed that RECQL5 overexpression inhibited proliferation, induced G1-phase arrest and promoted apoptosis in MG-63 cells. Collectively, our results suggested RECQL5 as a tumor suppressor in osteosarcoma and may be a potential therapeutic target for osteosarcoma treatment. - Highlights: • The expression of RECQL5 was downregulated in osteosarcoma tissues and cells. • Decreased RECQL5 correlated with osteosarcoma Enneking surgical classification. • We constructed a stable RECQL5 overexpression cell line by CRISPR/Cas9 system. • RECQL5 overexpression inhibited proliferation of MG-63 cells. • RECQL5 overexpression promoted apoptosis of MG-63 cells.

Validation for Global Solar Wind Prediction Using Ulysses Comparison: Multiple Coronal and Heliospheric Models Installed at the Community Coordinated Modeling Center

Science.gov (United States)

Jian, L. K.; MacNeice, P. J.; Mays, M. L.; Taktakishvili, A.; Odstrcil, D.; Jackson, B.; Yu, H.-S.; Riley, P.; Sokolov, I. V.

2016-01-01

The prediction of the background global solar wind is a necessary part of space weather forecasting. Several coronal and heliospheric models have been installed and/or recently upgraded at the Community Coordinated Modeling Center (CCMC), including the Wang-Sheely-Arge (WSA)-Enlil model, MHD-Around-a-Sphere (MAS)-Enlil model, Space Weather Modeling Framework (SWMF), and Heliospheric tomography using interplanetary scintillation data. Ulysses recorded the last fast latitudinal scan from southern to northern poles in 2007. By comparing the modeling results with Ulysses observations over seven Carrington rotations, we have extended our third-party validation from the previous near-Earth solar wind to middle to high latitudes, in the same late declining phase of solar cycle 23. Besides visual comparison, wehave quantitatively assessed the models capabilities in reproducing the time series, statistics, and latitudinal variations of solar wind parameters for a specific range of model parameter settings, inputs, and grid configurations available at CCMC. The WSA-Enlil model results vary with three different magnetogram inputs.The MAS-Enlil model captures the solar wind parameters well, despite its underestimation of the speed at middle to high latitudes. The new version of SWMF misses many solar wind variations probably because it uses lower grid resolution than other models. The interplanetary scintillation-tomography cannot capture the latitudinal variations of solar wind well yet. Because the model performance varies with parameter settings which are optimized for different epochs or flow states, the performance metric study provided here can serve as a template that researchers can use to validate the models for the time periods and conditions of interest to them.

Validation for global solar wind prediction using Ulysses comparison: Multiple coronal and heliospheric models installed at the Community Coordinated Modeling Center

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Jian, L. K.; MacNeice, P. J.; Mays, M. L.; Taktakishvili, A.; Odstrcil, D.; Jackson, B.; Yu, H.-S.; Riley, P.; Sokolov, I. V.

2016-08-01

The prediction of the background global solar wind is a necessary part of space weather forecasting. Several coronal and heliospheric models have been installed and/or recently upgraded at the Community Coordinated Modeling Center (CCMC), including the Wang-Sheely-Arge (WSA)-Enlil model, MHD-Around-a-Sphere (MAS)-Enlil model, Space Weather Modeling Framework (SWMF), and heliospheric tomography using interplanetary scintillation data. Ulysses recorded the last fast latitudinal scan from southern to northern poles in 2007. By comparing the modeling results with Ulysses observations over seven Carrington rotations, we have extended our third-party validation from the previous near-Earth solar wind to middle to high latitudes, in the same late declining phase of solar cycle 23. Besides visual comparison, we have quantitatively assessed the models' capabilities in reproducing the time series, statistics, and latitudinal variations of solar wind parameters for a specific range of model parameter settings, inputs, and grid configurations available at CCMC. The WSA-Enlil model results vary with three different magnetogram inputs. The MAS-Enlil model captures the solar wind parameters well, despite its underestimation of the speed at middle to high latitudes. The new version of SWMF misses many solar wind variations probably because it uses lower grid resolution than other models. The interplanetary scintillation-tomography cannot capture the latitudinal variations of solar wind well yet. Because the model performance varies with parameter settings which are optimized for different epochs or flow states, the performance metric study provided here can serve as a template that researchers can use to validate the models for the time periods and conditions of interest to them.

Effect of current sheets on the solar wind magnetic field power spectrum from the Ulysses observation: from Kraichnan to Kolmogorov scaling.

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Li, G; Miao, B; Hu, Q; Qin, G

2011-03-25

The MHD turbulence theory developed by Iroshnikov and Kraichnan predicts a k(-1.5) power spectrum. Solar wind observations, however, often show a k(-5/3) Kolmogorov scaling. Based on 3 years worth of Ulysses magnetic field data where over 28,000 current sheets are identified, we propose that the current sheet is the cause of the Kolmogorov scaling. We show that for 5 longest current-sheet-free periods the magnetic field power spectra are all described by the Iroshnikov-Kraichnan scaling. In comparison, for 5 periods that have the most number of current sheets, the power spectra all exhibit Kolmogorov scaling. The implication of our results is discussed.

Decreased serum hepcidin concentration correlates with brain iron deposition in patients with HBV-related cirrhosis.

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Dong Lin

Full Text Available PURPOSE: Excessive brain iron accumulation contributes to cognitive impairments in hepatitis B virus (HBV-related cirrhotic patients. The underlying mechanism remains unclear. Hepcidin, a liver-produced, 25-aminoacid peptide, is the major regulator of systemic iron metabolism. Abnormal hepcidin level is a key factor in some body iron accumulation or deficiency disorders, especially in those associated with liver diseases. Our study was aimed to explore the relationship between brain iron content in patients with HBV-related cirrhosis and serum hepcidin level. METHODS: Seventy HBV-related cirrhotic patients and forty age- sex-matched healthy controls were enrolled. Brain iron content was quantified by susceptibility weighted phase imaging technique. Serum hepcidin as well as serum iron, serum transferrin, ferritin, soluble transferrin receptor, total iron binding capacity, and transferrin saturation were tested in thirty cirrhotic patients and nineteen healthy controls. Pearson correlation analysis was performed to investigate correlation between brain iron concentrations and serum hepcidin, or other iron parameters. RESULTS: Cirrhotic patients had increased brain iron accumulation compared to controls in the left red nuclear, the bilateral substantia nigra, the bilateral thalamus, the right caudate, and the right putamen. Cirrhotic patients had significantly decreased serum hepcidin concentration, as well as lower serum transferring level, lower total iron binding capacity and higher transferrin saturation, compared to controls. Serum hepcidin level negatively correlated with the iron content in the right caudate, while serum ferritin level positively correlated with the iron content in the bilateral putamen in cirrhotic patients. CONCLUSIONS: Decreased serum hepcidin level correlated with excessive iron accumulation in the basal ganglia in HBV-related cirrhotic patients. Our results indicated that systemic iron overload underlined regional

HEMISPHERIC ASYMMETRIES IN THE POLAR SOLAR WIND OBSERVED BY ULYSSES NEAR THE MINIMA OF SOLAR CYCLES 22 AND 23

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Ebert, R. W.; Dayeh, M. A.; Desai, M. I.; McComas, D. J. [Southwest Research Institute, P.O. Drawer 28510, San Antonio, TX 78228 (United States); Pogorelov, N. V. [Physics Department, University of Alabama in Huntsville, Huntsville, AL 35899 (United States)

2013-05-10

We examined solar wind plasma and interplanetary magnetic field (IMF) observations from Ulysses' first and third orbits to study hemispheric differences in the properties of the solar wind and IMF originating from the Sun's large polar coronal holes (PCHs) during the declining and minimum phase of solar cycles 22 and 23. We identified hemispheric asymmetries in several parameters, most notably {approx}15%-30% south-to-north differences in averages for the solar wind density, mass flux, dynamic pressure, and energy flux and the radial and total IMF magnitudes. These differences were driven by relatively larger, more variable solar wind density and radial IMF between {approx}36 Degree-Sign S-60 Degree-Sign S during the declining phase of solar cycles 22 and 23. These observations indicate either a hemispheric asymmetry in the PCH output during the declining and minimum phase of solar cycles 22 and 23 with the southern hemisphere being more active than its northern counterpart, or a solar cycle effect where the PCH output in both hemispheres is enhanced during periods of higher solar activity. We also report a strong linear correlation between these solar wind and IMF parameters, including the periods of enhanced PCH output, that highlight the connection between the solar wind mass and energy output and the Sun's magnetic field. That these enhancements were not matched by similar sized variations in solar wind speed points to the mass and energy responsible for these increases being added to the solar wind while its flow was subsonic.

HEMISPHERIC ASYMMETRIES IN THE POLAR SOLAR WIND OBSERVED BY ULYSSES NEAR THE MINIMA OF SOLAR CYCLES 22 AND 23

International Nuclear Information System (INIS)

Ebert, R. W.; Dayeh, M. A.; Desai, M. I.; McComas, D. J.; Pogorelov, N. V.

2013-01-01

We examined solar wind plasma and interplanetary magnetic field (IMF) observations from Ulysses' first and third orbits to study hemispheric differences in the properties of the solar wind and IMF originating from the Sun's large polar coronal holes (PCHs) during the declining and minimum phase of solar cycles 22 and 23. We identified hemispheric asymmetries in several parameters, most notably ∼15%-30% south-to-north differences in averages for the solar wind density, mass flux, dynamic pressure, and energy flux and the radial and total IMF magnitudes. These differences were driven by relatively larger, more variable solar wind density and radial IMF between ∼36°S-60°S during the declining phase of solar cycles 22 and 23. These observations indicate either a hemispheric asymmetry in the PCH output during the declining and minimum phase of solar cycles 22 and 23 with the southern hemisphere being more active than its northern counterpart, or a solar cycle effect where the PCH output in both hemispheres is enhanced during periods of higher solar activity. We also report a strong linear correlation between these solar wind and IMF parameters, including the periods of enhanced PCH output, that highlight the connection between the solar wind mass and energy output and the Sun's magnetic field. That these enhancements were not matched by similar sized variations in solar wind speed points to the mass and energy responsible for these increases being added to the solar wind while its flow was subsonic.

Correlates and geographic patterns of knowledge that physical activity decreases cancer risk.

Science.gov (United States)

Ramírez, A Susana; Finney Rutten, Lila J; Vanderpool, Robin C; Moser, Richard P; Hesse, Bradford W

2013-04-01

While many lifestyle-related cancer risk factors including tobacco use, poor diet, and sun exposure are well recognized by the general public, the role of physical activity in decreasing cancer risk is less recognized. Studies have demonstrated gender-, race/ethnicity-, and age-based disparities in cancer risk factor knowledge; however, beliefs and geographic factors that may be related to knowledge are under-examined. In this study, we analyzed data from the 2008 Health Information National Trends Survey to determine correlates of knowledge of the relationship between physical activity and reduced cancer risk in the adult US population. We generated geographic information system maps to examine the geographic distribution of this knowledge. Results revealed that there is confusion among US adults about the relationship between physical activity and cancer risk: Respondents who believed that cancer is not preventable had significantly lower odds of knowing that physical activity reduces cancer risk (p physical activity reduces cancer risk (p physical activity guidelines were also significantly more likely to know that physical activity reduces cancer risk (p physical inactivity. Correlates of cancer risk factor knowledge point to opportunities for targeted interventions.

Correlated cone noise decreases rod signal contributions to the post-receptoral pathways.

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Hathibelagal, Amithavikram R; Feigl, Beatrix; Zele, Andrew J

2018-04-01

This study investigated how invisible extrinsic temporal white noise that correlates with the activity of one of the three [magnocellular (MC), parvocellular (PC), or koniocellular (KC)] post-receptoral pathways alters mesopic rod signaling. A four-primary photostimulator provided independent control of the rod and three cone photoreceptor excitations. The rod contributions to the three post-receptoral pathways were estimated by perceptually matching a 20% contrast rod pulse by independently varying the LMS (MC pathway), +L-M (PC pathway), and S-cone (KC pathway) excitations. We show that extrinsic cone noise caused a predominant decrease in the overall magnitude and ratio of the rod contributions to each pathway. Thus, the relative cone activity in the post-receptoral pathways determines the relative mesopic rod inputs to each pathway.

Latitudinal and radial variation of >2 GeV/n protons and alpha-particles at solar maximum: ULYSSES COSPIN/KET and neutron monitor network observations

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A. V. Belov

2003-06-01

Full Text Available Ulysses, launched in October 1990, began its second out-of-ecliptic orbit in September 1997. In 2000/2001 the spacecraft passed from the south to the north polar regions of the Sun in the inner heliosphere. In contrast to the first rapid pole to pole passage in 1994/1995 close to solar minimum, Ulysses experiences now solar maximum conditions. The Kiel Electron Telescope (KET measures also protons and alpha-particles in the energy range from 5 MeV/n to >2 GeV/n. To derive radial and latitudinal gradients for >2 GeV/n protons and alpha-particles, data from the Chicago instrument on board IMP-8 and the neutron monitor network have been used to determine the corresponding time profiles at Earth. We obtain a spatial distribution at solar maximum which differs greatly from the solar minimum distribution. A steady-state approximation, which was characterized by a small radial and significant latitudinal gradient at solar minimum, was interchanged with a highly variable one with a large radial and a small – consistent with zero – latitudinal gradient. A significant deviation from a spherically symmetric cosmic ray distribution following the reversal of the solar magnetic field in 2000/2001 has not been observed yet. A small deviation has only been observed at northern polar regions, showing an excess of particles instead of the expected depression. This indicates that the reconfiguration of the heliospheric magnetic field, caused by the reappearance of the northern polar coronal hole, starts dominating the modulation of galactic cosmic rays already at solar maximum.Key words. Interplanetary physics (cosmic rays; energetic particles – Space plasma physics (charged particle motion and acceleration

Cerebral hyperperfusion and decreased cerebrovascular reactivity correlate with neurologic disease severity in MELAS.

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Rodan, L H; Poublanc, J; Fisher, J A; Sobczyk, O; Wong, T; Hlasny, E; Mikulis, D; Tein, I

2015-05-01

To study the mechanisms underlying stroke-like episodes (SLEs) in MELAS syndrome. We performed a case control study in 3 siblings with MELAS syndrome (m.3243A>G tRNA(Leu(UUR))) with variable % mutant mtDNA in blood (35 to 59%) to evaluate regional cerebral blood flow (CBF) and arterial cerebrovascular reactivity (CVR) compared to age- and sex-matched healthy study controls and a healthy control population. Subjects were studied at 3T MRI using arterial spin labeling (ASL) to measure CBF; CVR was measured as a change in % Blood Oxygen Level Dependent signal (as a surrogate of CBF) to repeated 10 mmHg step increase in arterial partial pressure of CO2 (PaCO2). MELAS siblings had decreased CVR (p ≤ 0.002) and increased CBF (p MELAS disease severity and mutation load were inversely correlated with Interictal CVR and directly correlated with frontal CBF. These metrics offer further insight into the cerebrovascular hemodynamics in MELAS syndrome and may serve as noninvasive prognostic markers to stratify risk for SLEs. Class III. Copyright © 2015 © Elsevier B.V. and Mitochondria Research Society. Published by Elsevier B.V. All rights reserved.

Joyce and Ulysses: integrated and user-friendly tools for the parameterization of intramolecular force fields from quantum mechanical data.

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Barone, Vincenzo; Cacelli, Ivo; De Mitri, Nicola; Licari, Daniele; Monti, Susanna; Prampolini, Giacomo

2013-03-21

The Joyce program is augmented with several new features, including the user friendly Ulysses GUI, the possibility of complete excited state parameterization and a more flexible treatment of the force field electrostatic terms. A first validation is achieved by successfully comparing results obtained with Joyce2.0 to literature ones, obtained for the same set of benchmark molecules. The parameterization protocol is also applied to two other larger molecules, namely nicotine and a coumarin based dye. In the former case, the parameterized force field is employed in molecular dynamics simulations of solvated nicotine, and the solute conformational distribution at room temperature is discussed. Force fields parameterized with Joyce2.0, for both the dye's ground and first excited electronic states, are validated through the calculation of absorption and emission vertical energies with molecular mechanics optimized structures. Finally, the newly implemented procedure to handle polarizable force fields is discussed and applied to the pyrimidine molecule as a test case.

Energetic Charged-Particle Phenomena in the Jovian Magnetosphere: First Results from the Ulysses COSPIN Collaboration.

Science.gov (United States)

Simpson, J A; Anglin, J D; Balogh, A; Burrows, J R; Cowley, S W; Ferrando, P; Heber, B; Hynds, R J; Kunow, H; Marsden, R G; McKibben, R B; Müller-Mellin, R; Page, D E; Raviart, A; Sanderson, T R; Staines, K; Wenzel, K P; Wilson, M D; Zhang, M

1992-09-11

The Ulysses spacecraft made the first exploration of the region of Jupiter's magnetosphere at high Jovigraphic latitudes ( approximately 37 degrees south) on the dusk side and reached higher magnetic latitudes ( approximately 49 degrees north) on the day side than any previous mission to Jupiter. The cosmic and solar particle investigations (COSPIN) instrumentation achieved a remarkably well integrated set of observations of energetic charged particles in the energy ranges of approximately 1 to 170 megaelectron volts for electrons and 0.3 to 20 megaelectron volts for protons and heavier nuclei. The new findings include (i) an apparent polar cap region in the northern hemisphere in which energetic charged particles following Jovian magnetic field lines may have direct access to the interplanetary medium, (ii) high-energy electron bursts (rise times approximately 17 megaelectron volts) on the dusk side that are apparently associated with field-aligned currents and radio burst emissions, (iii) persistence of the global 10-hour relativistic electron "clock" phenomenon throughout Jupiter's magnetosphere, (iv) on the basis of charged-particle measurements, apparent dragging of magnetic field lines at large radii in the dusk sector toward the tail, and (v) consistent outflow of megaelectron volt electrons and large-scale departures from corotation for nucleons.

Fatigue correlates with the decrease in parasympathetic sinus modulation induced by a cognitive challenge

Science.gov (United States)

2014-01-01

Background It is known that enhancement of sympathetic nerve activity based on a decrease in parasympathetic nerve activity is associated with fatigue induced by mental tasks lasting more than 30 min. However, to measure autonomic nerve function and assess fatigue levels in both clinical and industrial settings, shorter experimental durations and more sensitive measurement methods are needed. The aim of the present study was to establish an improved method for inducing fatigue and evaluating the association between it and autonomic nerve activity. Methods Twenty-eight healthy female college students participated in the study. We used a kana pick-out test (KPT) as a brief verbal cognitive task and recorded electrocardiography (ECG) to measure autonomic nerve activity. The experimental design consisted of a 16-min period of ECG: A pre-task resting state with eyes open for 3 min and eyes closed for 3 min, the 4-min KPT, and a post-task resting state with eyes open for 3 min and eyes closed for 3 min. Results Baseline fatigue sensation, measured by a visual analogue scale before the experiment, was associated with the decrease in parasympathetic sinus modulation, as indicated the by ratio of low-frequency component power (LF) to high-frequency component power (HF), during the KPT. The LF/HF ratio during the post-KPT rest with eyes open tended to be greater than the ratio during the KPT and correlated with fatigue sensation. Fatigue sensation was correlated negatively with log-transformed HF, which is an index of parasympathetic sinus modulation, during the post-KPT rest with eyes open. Conclusions The methods described here are useful for assessing the association between fatigue sensation and autonomic nerve activity using a brief cognitive test in healthy females. PMID:25069864

Decreasing fertility rate correlates with the chronological increase and geographical variation in incidence of Kawasaki disease in Japan.

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Yoshiro Nagao

Full Text Available BACKGROUND: Kawasaki disease (KD is a common cause of acquired paediatric heart disease in developed countries. KD was first identified in the 1960s in Japan, and has been steadily increasing since it was first reported. The aetiology of KD has not been defined, but is assumed to be infection-related. The present study sought to identify the factor(s that mediate the geographical variation and chronological increase of KD in Japan. METHODS AND FINDINGS: Based upon data reported between 1979 and 2010 from all 47 prefectures in Japan, the incidence and mean patient age at the onset of KD were estimated. Using spatial and time-series analyses, incidence and mean age were regressed against climatic/socioeconomic variables. Both incidence and mean age of KD were inversely correlated with the total fertility rate (TFR; i.e., the number of children that would be born to one woman. The extrapolation of a time-series regressive model suggested that KD emerged in the 1960s because of a dramatic decrease in TFR in the 1940s through the 1950s. CONCLUSIONS: Mean patient age is an inverse surrogate for the hazard of contracting the aetiologic agent. Therefore, the observed negative correlation between mean patient age and TFR suggests that a higher TFR is associated with KD transmission. This relationship may be because a higher TFR facilitates sibling-to-sibling transmission. Additionally, the observed inverse correlation between incidence and TFR implies a paradoxical "negative" correlation between the incidence and the hazard of contracting the aetiologic agent. It was hypothesized that a decreasing TFR resulted in a reduced hazard of contracting the agent for KD, thereby increasing KD incidence.

Ulysses observations of magnetic waves due to newborn interstellar pickup ions. I. New observations and linear analysis

Energy Technology Data Exchange (ETDEWEB)

Cannon, Bradford E. [Physics Department, Florida State University, Tallahassee, FL (United States); Smith, Charles W.; Isenberg, Philip A.; Vasquez, Bernard J. [Physics Department and Space Science Center, Institute for the Study of Earth, Oceans, and Space, University of New Hampshire, Durham, NH (United States); Murphy, Neil [Jet Propulsion Laboratory, Mail Stop 180-600, 4800 Oak Grove Drive, Pasadena, CA (United States); Nuno, Raquel G., E-mail: bc13h@my.fsu.edu, E-mail: Charles.Smith@unh.edu, E-mail: Phil.Isenberg@unh.edu, E-mail: Bernie.Vasquez@unh.edu, E-mail: Neil.Murphy@jpl.nasa.gov, E-mail: raquel.nuno@asu.edu [School of Earth and Space Exploration, Arizona State University, Tempe, AZ (United States)

2014-04-01

We have examined Ulysses magnetic field data using dynamic spectrogram techniques that compute wave amplitude, polarization, and direction of propagation over a broad range of frequencies and time. Events were identified that showed a strong polarization signature and an enhancement of power above the local proton gyrofrequency. We perform a statistical study of 502 wave events in an effort to determine when, where, and why they are observed. Most notably, we find that waves arising from newborn interstellar pickup ions are relatively rare and difficult to find. The quantities normally employed in theories of wave growth are neutral atom density and quantities related to their ionization and the subsequent dynamics such as wind speed, solar wind flux, and magnetic field orientation. We find the observations of waves to be largely uncorrelated to these quantities except for mean field direction where quasi-radial magnetic fields are favored and solar wind proton flux where wave observations appear to be favored by low flux conditions which runs contrary to theoretical expectations of wave generation. It would appear that an explanation based on source physics and instability growth rates alone is not adequate to account for the times when these waves are seen.

Interspecific correlates of plasticity in relative growth rate following a decrease in nitrogen availability.

Science.gov (United States)

Useche, Antonio; Shipley, Bill

2010-02-01

Nitrogen availability varies greatly over short time scales. This requires that a well-adapted plant modify its phenotype by an appropriate amount and at a certain speed in order to maximize growth and fitness. To determine how plastic ontogenetic changes in each trait interact and whether or not these changes are likely to maximize growth, ontogenetic changes in relative growth rate (RGR), net assimilation rate (NAR), specific leaf area (SLA) and root weight ratio (RWR), before and after a decrease in nitrogen supply, were studied in 14 herbaceous species. Forty-four plants of each species were grown in hydroponic culture under controlled conditions in a control treatment where the supply of nitrogen remained constant at 1 mm, and in a stress treatment where the nitrogen supply was abruptly decreased from 1 to 0.01 mm during the growth period. In the treatment series, and in comparison with the control, NAR and RGR decreased, RWR increased, and SLA did not change except for the timing of ontogenetic change. Species having greater increases in the maximum rate of change in RWR also had smaller reductions in RGR; plasticity in RWR is therefore adaptive. In contrast, species which showed a greater decrease in NAR showed stronger reductions in RGR; plasticity in NAR is therefore not adaptive. Plasticity in RGR was not related to plasticity in SLA. There were no significant relationships among the plasticities in NAR, RWR or SLA. Potentially fast-growing species experienced larger reductions in RGR following the nitrogen reduction. These results suggest that competitive responses to interspecific competition for nitrogen might be positively correlated with the plasticity in the maximum rate of change in RWR in response to a reduction in nitrogen supply.

Characterization of radioactive graphite and concrete of the reactor ULYSSE/INSTN at CEA/Saclay to be dismantled

International Nuclear Information System (INIS)

Van Lauwe, Aymeric; Ridikas, Danas; Damoy, Francois; Blideanu, Valentin; Fajardo, Christophe; Aubert, Marie-Cecile; Foulon, Francois

2006-01-01

Decommissioning and dismantling of nuclear installations after their service life are connected with the necessity of the disassembling, handling and disposing of a large amount of radioactive material. In order to optimize the disassembling operations, to reduce the undesirable volume to the minimum and to successfully plan the dismantling and disposal of radioactive materials to storage facilities, the radiological characterisation of the material present in the reactor and around its environment should be accurately evaluated. The present work has been done in the framework of the decommissioning and dismantling of the experimental reactor ULYSSE that is presently operating in INSTN/Saclay and will be closed in the middle of 2006. A methodology, already successfully used for another research reactor, is proposed for determining accurately the long-term induced activity of the materials present in the active reactor core and its surroundings. The comparison of theoretical predictions, based on Monte Carlo technique, with experimental values validated the approach and the methodology used in the present study. The goal is to plan efficiently the disassembling and dismantling of the system and to optimise the mass flow going to different waste repositories. We show that this approach might reduce substantially the total cost of decommissioning. (authors)

Spatial gradients of GCR protons in the inner heliosphere derived from Ulysses COSPIN/KET and PAMELA measurements

Science.gov (United States)

Gieseler, J.; Heber, B.

2016-05-01

Context. During the transition from solar cycle 23 to 24 from 2006 to 2009, the Sun was in an unusual solar minimum with very low activity over a long period. These exceptional conditions included a very low interplanetary magnetic field (IMF) strength and a high tilt angle, which both play an important role in the modulation of galactic cosmic rays (GCR) in the heliosphere. Thus, the radial and latitudinal gradients of GCRs are very much expected to depend not only on the solar magnetic epoch, but also on the overall modulation level. Aims: We determine the non-local radial and the latitudinal gradients of protons in the rigidity range from ~0.45 to 2 GV. Methods: This was accomplished by using data from the satellite-borne experiment Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics (PAMELA) at Earth and the Kiel Electron Telescope (KET) onboard Ulysses on its highly inclined Keplerian orbit around the Sun with the aphelion at Jupiter's orbit. Results: In comparison to the previous A> 0 solar magnetic epoch, we find that the absolute value of the latitudinal gradient is lower at higher and higher at lower rigidities. This energy dependence is therefore a crucial test for models that describe the cosmic ray transport in the inner heliosphere.

Decreased expression of Beclin 1 correlates closely with Bcl-xL expression and poor prognosis of ovarian carcinoma.

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Huan-Xin Lin

Full Text Available It has been suggested that autophagy-related Beclin 1 plays a critical role in the regulation of tumor development and/or progression, but its prognostic significance and relationship with Bcl-xL expression in ovarian carcinoma are unclear.In the present study, the methods of Western blotting and immunohistochemistry (IHC were utilized to investigate the expression status of Beclin 1 and Bcl-xL in fresh ovarian tissues and paraffin-embedded epithelial ovarian tumor tissues. Decreased expression of Beclin 1 was examined by IHC in 8.3% of normal ovaries, in 15.4% of cystadenomas, in 20.0% of borderline tumors, and in 55.6% of ovarian carcinomas, respectively. In ovarian carcinomas, decreased expression of Beclin 1 was correlated closely with ascending histological grade, later pT/pN/pM status and/or advanced clinical stage (P<0.05. In univariate survival analysis, a highly significant association between low-expressed Beclin 1 and shortened patient survival was evaluated in ovarian carcinoma patients (P<0.01, and Beclin 1 expression was an independent prognostic factor as evidenced by multivariate analysis (P = 0.013. In addition, decreased expression of Beclin 1 was inversely correlated with altered expression of Bcl-xL in ovarian carcinoma cohort, and combined analysis further showed that the low Beclin 1/high Bcl-xL group had the lowest survival rate.Our findings suggest that Beclin 1 expression, as examined by IHC, could be served as an additional tool in identifying ovarian carcinoma patients at risk of tumor progression, and predicting patient survival in ovarian carcinomas with increased expression of Bcl-xL.

Radial Variations of Outward and Inward Alfvénic Fluctuations Based on Ulysses Observations

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Yang, L.; Lee, L. C.; Li, J. P.; Luo, Q. Y.; Kuo, C. L.; Shi, J. K.; Wu, D. J.

2017-12-01

Ulysses magnetic and plasma data are used to study hourly scale Alfvénic fluctuations in the solar polar wind. The calculated energy ratio {R}{vA}2(cal) of inward to outward Alfvén waves is obtained from the observed Walén slope through an analytical expression, and the observed {R}{vA}2(obs) is based on a direct decomposition of original Alfvénic fluctuations into outward- and inward-propagating Alfvén waves. The radial variation of {R}{vA}2(cal) shows a monotonically increasing trend with heliocentric distance r, implying the increasing local generation or contribution of inward Alfvén waves. The contribution is also shown by the radial increase in the occurrence of dominant inward fluctuations. We further pointed out a higher occurrence (˜ 83 % of a day in average) of dominant outward Alfvénic fluctuations in the solar wind than previously estimated. Since {R}{vA}2(cal) is more accurate than {R}{vA}2(obs) in the measurement of the energy ratio for dominant outward fluctuations, the values of {R}{vA}2(cal) in our results are likely more realistic in the solar wind than those previously estimated as well as {R}{vA}2(obs) in our results. The duration ratio R T of dominant inward to all Alfvénic fluctuations increases monotonically with r, and is about two or more times that from Voyager 2 observations at r≥slant 4 {au}. These results reveal new qualitative and quantitative features of Alfvénic fluctuations therein compared with previous studies and put constraints on modeling the variation of solar wind fluctuations.

The cosmic ray and solar flare isotope experiments in the CRRES, NOAA-I and ''Ulysses'' satellites

International Nuclear Information System (INIS)

Garcia-Munoz, M.

1990-01-01

The ONR-604 instrument has been designed to measure the energy spectra and the isotopic composition at 1 AU of the elements Hydrogen to Nickel in the energy range 40--500 MeV/n and will be carried by the Combined Release and Radiation Effects Satellite (CRRES) to be launched July, 1990 in a highly eccentric orbit between a low perigee and a synchronous orbit point. It will measure galactic cosmic rays, solar energetic particles, and trapped and pseudo-trapped particles in the Earth magnetosphere. Also at 1 AU, the Energetic Heavy Ion Composition (EHIC) instrument, designed to study mainly the elemental and isotopic composition of solar energetic particles over the charge range H to Ni, in the energy range 0.5 to 200 MeV/n, will be placed in a Sun-synchronous circular polar orbit of 833 or 870 km altitude by a NOAA-I satellite scheduled to be launched late 1990 or early 1991. The University of Chicago High Energy Telescope (HET) experiment which is part of the COSPIN consortium on the ''Ulysses'' mission will measure the energy spectra and the isotopic composition of the elments Hydrogen to Nickel in the energy interval 20--450 MeV/n in the heliosphere, both the ecliptic plane and at high heliographic latitudes in an orbit around the Sun that will have an aphelion near a Jupiter orbit point and a perhelion of about 1.4 AU. It will be launched October 1990

Decrease in plasma high-density lipoprotein cholesterol levels at puberty in boys with delayed adolescence: correlation with plasma testosterone levels

International Nuclear Information System (INIS)

Kirkland, R.T.; Keenan, B.S.; Probstfield, J.L.; Patsch, W.; Lin, T.L.; Clayton, G.W.; Insull, W. Jr.

1987-01-01

A three-phase study tested the hypothesis that the decrease in the high-density lipoprotein cholesterol (HDL-C) level observed in boys at puberty is related to an increase in the plasma testosterone concentration. In phase I, 57 boys aged 10 to 17 years were categorized into four pubertal stages based on clinical parameters and plasma testosterone levels. These four groups showed increasing plasma testosterone values and decreasing HDL-C levels. In phase II, 14 boys with delayed adolescence were treated with testosterone enanthate. Plasma testosterone levels during therapy were in the adult male range. Levels of HDL-C decreased by a mean of 7.4 mg/dL (0.20 mmol/L) and 13.7 mg/dL (0.35 mmol/L), respectively, after the first two doses. In phase III, 13 boys with delayed adolescence demonstrated increasing plasma testosterone levels and decreasing HDL-C levels during spontaneous puberty. Levels of HDL-C and apolipoprotein A-1 were correlated during induced and spontaneous puberty. Testosterone should be considered a significant determinant of plasma HDL-C levels during pubertal development

Decreased plasma levels of factor II + VII + X correlate with increased levels of soluble cytokine receptors in patients with malaria and meningococcal infections

DEFF Research Database (Denmark)

Bygbjerg, I C; Hansen, M B; Rønn, A M

1997-01-01

The levels of coagulation factors II + VII + X and of blood platelets (thrombocytes) as well as of cytokines and soluble cytokine receptors were studied in the patients with malaria or meningococcal infections. The coagulation factors were decreased particularly in the meningococcal patients, while...... thrombocytes were lowest in the Plasmodium falciparum malaria patients. There was no correlation between factors II + VII + X and thrombocytes, but plasma levels of coagulation factors II + VII + X were found to correlate inversely with levels of soluble interleukin-2 receptor (sIL-2R) and soluble tumour...... necrosis factor-I (sTNF-RI) in patients with malaria and meningococcal infections. Elevated sIL-2R and sTNF-RI levels and decreased coagulation factors reverted to normal within 3-5 days after initiation of therapy in P. falciparum patients followed consecutively. Estimation of coagulation factors may...

Correlation of Magnetic Fields with Solar Wind Plasma Parameters at 1AU

Science.gov (United States)

Shen, F.

2017-12-01

The physical parameters of the solar wind observed in-situ near 1AU have been studied for several decades, and relationships between them, such as the positive correlation between the solar wind plasma temperature T and velocity V, and the negative correlation between density N and velocity V, are well known. However, the magnetic field intensity does not appear to be well correlated with any individual plasma parameter. In this paper, we discuss previously under-reported correlations between B and the combined plasma parameters √NV2 as well as between B and √NT. These two correlations are strong during the periods of corotating interaction regions and high speed streams, moderate during intervals of slow solar wind, and rather poor during the passage of interplanetary coronal mass ejections. The results indicate that the magnetic pressure in the solar wind is well correlated both with the plasma dynamic pressure and the thermal pressure. Then, we employ a 3D MHD model to simulate the formation of the relationships between the magnetic strength B and √NV2 as well as √NT observed at 1AU. The inner boundary condition is derived by empirical models, with the magnetic field and density are optional. Five kinds of boundary conditions at the inner boundary of heliosphere are tested. In the cases that the magnetic field is related to speed at the inner boundary, the correlation coefficients between B and √NV2 as well as between B and √NT are even higher than that in the observational results. At 1AU the simulated radial magnetic field shows little latitude dependence, which matches the observation of Ulysses. Most of the modeled characters in these cases are closer to observation than others. This inner boundary condition may more accurately characterize Sun's magnetic influence on the heliosphere. The new input may be able to improve the simulation of CME propagation in the inner heliosphere and the space weather forecasting.

Prion protein is decreased in Alzheimer's brain and inversely correlates with BACE1 activity, amyloid-β levels and Braak stage.

Directory of Open Access Journals (Sweden)

Isobel J Whitehouse

Full Text Available The cellular prion protein (PrP(C has been implicated in the development of Alzheimer's disease (AD. PrP(C decreases amyloid-β (Aβ production, which is involved in AD pathogenesis, by inhibiting β-secretase (BACE1 activity. Contactin 5 (CNTN5 has also been implicated in the development of AD by a genome-wide association study. Here we measured PrP(C and CNTN5 in frontal cortex samples from 24 sporadic AD and 24 age-matched control brains and correlated the expression of these proteins with markers of AD. PrP(C was decreased in sporadic AD compared to controls (by 49%, p = 0.014 but there was no difference in CNTN5 between sporadic AD and controls (p = 0.217. PrP(C significantly inversely correlated with BACE1 activity (rs = -0.358, p = 0.006, Aβ load (rs = -0.456, p = 0.001, soluble Aβ (rs = -0.283, p = 0.026 and insoluble Aβ (rs = -0.353, p = 0.007 and PrP(C also significantly inversely correlated with the stage of disease, as indicated by Braak tangle stage (rs = -0.377, p = 0.007. CNTN5 did not correlate with Aβ load (rs = 0.040, p = 0.393, soluble Aβ (rs = 0.113, p = 0.223 or insoluble Aβ (rs = 0.169, p = 0.125. PrP(C was also measured in frontal cortex samples from 9 Down's syndrome (DS and 8 age-matched control brains. In contrast to sporadic AD, there was no difference in PrP(C in the DS brains compared to controls (p = 0.625. These data are consistent with a role for PrP(C in regulating Aβ production and indicate that brain PrP(C level may be important in influencing the onset and progression of sporadic AD.

Ulysses observations of magnetic waves due to newborn interstellar pickup ions. II. Application of turbulence concepts to limiting wave energy and observability

Energy Technology Data Exchange (ETDEWEB)

Cannon, Bradford E. [Physics Department, Florida State University, Tallahassee, FL 32306 (United States); Smith, Charles W.; Isenberg, Philip A.; Vasquez, Bernard J.; Joyce, Colin J. [Physics Department and Space Science Center, Institute for the Study of Earth, Oceans, and Space, University of New Hampshire, Durham, NH 03824 (United States); Murphy, Neil [Jet Propulsion Laboratory, Mail Stop 180-600, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Nuno, Raquel G., E-mail: bc13h@my.fsu.edu, E-mail: Charles.Smith@unh.edu, E-mail: Phil.Isenberg@unh.edu, E-mail: Bernie.Vasquez@unh.edu, E-mail: cjl46@wildcats.unh.edu, E-mail: Neil.Murphy@jpl.nasa.gov, E-mail: raquel.nuno@asu.edu [School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287 (United States)

2014-06-01

The low-frequency magnetic waves that arise from the isotropization of newborn interstellar pickup ions (PUIs) are reasonably well described by linear and quasi-linear kinetic theory in so far as those theories predict the wave frequency and polarization in the spacecraft frame. Those theories fail to describe the scarce observability of the waves. Quasilinear theory predicts that the wave power should accumulate over long periods of time as the relatively weak kinetic instability slowly adds power to the observed spectrum. At the same time it has been argued that the same wave energy must serve as a secondary source of thermal ion heating in the outer heliosphere once the initial turbulence is depleted. To the extent that turbulent transport of the wave energy acts against the spectrally confined accumulation of wave energy, turbulence should be a limiting factor in observability. We argue that turbulence does limit the observability of the waves and we use turbulence theory to predict the observed wave energy. We compare this prediction against a database of 502 wave observations attributed to newborn interstellar PUIs observed by the Ulysses spacecraft.

Ulysses observations of magnetic waves due to newborn interstellar pickup ions. II. Application of turbulence concepts to limiting wave energy and observability

International Nuclear Information System (INIS)

Cannon, Bradford E.; Smith, Charles W.; Isenberg, Philip A.; Vasquez, Bernard J.; Joyce, Colin J.; Murphy, Neil; Nuno, Raquel G.

2014-01-01

The low-frequency magnetic waves that arise from the isotropization of newborn interstellar pickup ions (PUIs) are reasonably well described by linear and quasi-linear kinetic theory in so far as those theories predict the wave frequency and polarization in the spacecraft frame. Those theories fail to describe the scarce observability of the waves. Quasilinear theory predicts that the wave power should accumulate over long periods of time as the relatively weak kinetic instability slowly adds power to the observed spectrum. At the same time it has been argued that the same wave energy must serve as a secondary source of thermal ion heating in the outer heliosphere once the initial turbulence is depleted. To the extent that turbulent transport of the wave energy acts against the spectrally confined accumulation of wave energy, turbulence should be a limiting factor in observability. We argue that turbulence does limit the observability of the waves and we use turbulence theory to predict the observed wave energy. We compare this prediction against a database of 502 wave observations attributed to newborn interstellar PUIs observed by the Ulysses spacecraft.

Decreased NAA in gray matter is correlated with decreased availability of acetate in white matter in postmortem multiple sclerosis cortex.

Science.gov (United States)

Li, S; Clements, R; Sulak, M; Gregory, R; Freeman, E; McDonough, J

2013-11-01

Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system (CNS) which leads to progressive neurological disability. Our previous studies have demonstrated mitochondrial involvement in MS cortical pathology and others have documented decreased levels of the neuronal mitochondrial metabolite N-acetyl aspartate (NAA) in the MS brain. While NAA is synthesized in neurons, it is broken down in oligodendrocytes into aspartate and acetate. The resulting acetate is incorporated into myelin lipids, linking neuronal mitochondrial function to oligodendrocyte-mediated elaboration of myelin lipids in the CNS. In the present study we show that treating human SH-SY5Y neuroblastoma cells with the electron transport chain inhibitor antimycin A decreased levels of NAA as measured by HPLC. To better understand the significance of the relationship between mitochondrial function and levels of NAA and its breakdown product acetate on MS pathology we then quantitated the levels of NAA and acetate in MS and control postmortem tissue blocks. Regardless of lesion status, we observed that levels of NAA were decreased 25 and 32 % in gray matter from parietal and motor cortex in MS, respectively, compared to controls. Acetate levels in adjacent white matter mirrored these decreases as evidenced by the 36 and 45 % reduction in acetate obtained from parietal and motor cortices. These data suggest a novel mechanism whereby mitochondrial dysfunction and reduced NAA levels in neurons may result in compromised myelination by oligodendrocytes due to decreased availability of acetate necessary for the synthesis of myelin lipids.

STATISTICAL STUDY ON THE DECAY PHASE OF SOLAR NEAR-RELATIVISTIC ELECTRON EVENTS

International Nuclear Information System (INIS)

Lario, D.

2010-01-01

We study the decay phase of solar near-relativistic (53-315 keV) electron events as observed by the Advanced Composition Explorer (ACE) and the Ulysses spacecraft during solar cycle 23. By fitting an exponential function (exp - t/τ) to the time-intensity profile in the late phase of selected solar near-relativistic electron events, we examine the dependence of τ on electron energy, electron intensity spectra, event peak intensity, event fluence, and solar wind velocity, as well as heliocentric radial distance, heliolatitude, and heliolongitude of the spacecraft with respect to the parent solar event. The decay rates are found to be either independent or slightly decrease with the electron energy. No clear dependence is found between τ and the heliolongitude of the parent solar event, with the exception of well-connected events for which low values of τ are more commonly observed than for poorly-connected events. For those events concurrently observed by ACE and Ulysses, decay rates increase at distances >3 AU. Events with similar decay rates at ACE and Ulysses were observed mainly when Ulysses was at high heliographic latitudes. We discuss the basic physical mechanisms that control the decay phase of the electron events and conclude that both solar wind convection and adiabatic deceleration effects influence the final shape of the decay phase of solar energetic particle events, but not as expressed by the models based on diffusive transport acting on an isotropic particle population.

Effects of cosmic ray decreases on cloud microphysics

DEFF Research Database (Denmark)

Svensmark, J.; Enghoff, M. B.; Svensmark, H.

2012-01-01

Using cloud data from MODIS we investigate the response of cloud microphysics to sudden decreases in galactic cosmic radiation – Forbush decreases – and find responses in effective emissivity, cloud fraction, liquid water content, and optical thickness above the 2–3 sigma level 6–9 days after...... the minimum in atmospheric ionization and less significant responses for effective radius and cloud condensation nuclei (... of the signal of 3.1 sigma. We also see a correlation between total solar irradiance and strong Forbush decreases but a clear mechanism connecting this to cloud properties is lacking. There is no signal in the UV radiation. The responses of the parameters correlate linearly with the reduction in the cosmic ray...

On the modernist elements of ‘Ithaca’ chapter in Joyce’s Ulysses: Engaging students in class discussion

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Roohollah Datli Beigi

2012-01-01

Full Text Available   James Joyce's Ulysses is one of the hall-marks of modernism in the realm of the novel. In this novel, Joyce breaks away from old patterns, employs new techniques, and presents the modern state of man as well as his soul-lacking indeterminate communication with others. Freud's theories on the unique and private quality of man's mode of consciousness and the meddling of the past with present, stressed the twentieth-century man's ill-condition and his position among his fellow beings. Joyce portrays the modern man in his favorite chapter, ‘Ithaca,’ which has certain features that make the narrative structure in complete step with Joyce's themes regarding the modern man. This paper is an attempt to show how the human race is perceived by Joyce, revealing how the employed elements depict a modern picture of the modern man. This chapter contains many questions and answers that can be discussed in class and students can be engaged in novel-based dialogues and class discussion as an EFL practice.

Decreased blood riboflavin levels are correlated with defective expression of RFT2 gene in gastric cancer

Science.gov (United States)

Eli, Maynur; Li, De-Sheng; Zhang, Wei-Wei; Kong, Bing; Du, Chen-Song; Wumar, Maimaitiaili; Mamtimin, Batur; Sheyhidin, Ilyar; Hasim, Ayshamgul

2012-01-01

AIM: To investigate the relationship between blood riboflavin levels and riboflavin transporter 2 (RFT2) gene expression in gastric carcinoma (GC) development. METHODS: High-performance liquid chromatography was used to detect blood riboflavin levels in patients with GC. Real-time fluorogenic quantitative polymerase chain reaction and immunohistochemistry were used to analyze the expression of RFT2 mRNA and protein in samples from 60 GC patients consisting of both tumor and normal tissue. RESULTS: A significant decrease in the RFT2 mRNA levels was detected in GC samples compared with those in the normal mucous membrane (0.398 ± 0.149 vs 1.479 ± 0.587; P = 0.040). Tumors exhibited low RFT2 protein expression (75%, 16.7%, 8.3% and 0% for no RFT2 staining, weak staining, medium staining and strong staining, respectively), which was significantly lower than that in the normal mucous membrane (10%, 16.7%, 26.7% and 46.7% for no RFT2 staining, weak staining, medium staining and strong staining, respectively; P riboflavin levels were reverse correlated with development of GC (1.2000 ± 0.97 569 ng/mL in high tumor stage patients vs 2.5980 ± 1.31 129 ng/mL in low tumor stage patients; P riboflavin levels with defective expression of RFT2 protein was found in GC patients (χ2 = 2.619; P = 0.019). CONCLUSION: Defective expression of RFT2 is associated with the development of GC and this may represent a mechanism underlying the decreased plasma riboflavin levels in GC. PMID:22791947

Effects of cosmic ray decreases on cloud microphysics

DEFF Research Database (Denmark)

Svensmark, J.; Enghoff, M. B.; Svensmark, H.

2012-01-01

the minimum in atmospheric ionization and less significant responses for effective radius and cloud condensation nuclei (total significance...... of the signal of 3.1 sigma. We also see a correlation between total solar irradiance and strong Forbush decreases but a clear mechanism connecting this to cloud properties is lacking. There is no signal in the UV radiation. The responses of the parameters correlate linearly with the reduction in the cosmic ray......Using cloud data from MODIS we investigate the response of cloud microphysics to sudden decreases in galactic cosmic radiation – Forbush decreases – and find responses in effective emissivity, cloud fraction, liquid water content, and optical thickness above the 2–3 sigma level 6–9 days after...

Decreased Cerebellar-Orbitofrontal Connectivity Correlates with Stuttering Severity: Whole-Brain Functional and Structural Connectivity Associations with Persistent Developmental Stuttering.

Science.gov (United States)

Sitek, Kevin R; Cai, Shanqing; Beal, Deryk S; Perkell, Joseph S; Guenther, Frank H; Ghosh, Satrajit S

2016-01-01

Persistent developmental stuttering is characterized by speech production disfluency and affects 1% of adults. The degree of impairment varies widely across individuals and the neural mechanisms underlying the disorder and this variability remain poorly understood. Here we elucidate compensatory mechanisms related to this variability in impairment using whole-brain functional and white matter connectivity analyses in persistent developmental stuttering. We found that people who stutter had stronger functional connectivity between cerebellum and thalamus than people with fluent speech, while stutterers with the least severe symptoms had greater functional connectivity between left cerebellum and left orbitofrontal cortex (OFC). Additionally, people who stutter had decreased functional and white matter connectivity among the perisylvian auditory, motor, and speech planning regions compared to typical speakers, but greater functional connectivity between the right basal ganglia and bilateral temporal auditory regions. Structurally, disfluency ratings were negatively correlated with white matter connections to left perisylvian regions and to the brain stem. Overall, we found increased connectivity among subcortical and reward network structures in people who stutter compared to controls. These connections were negatively correlated with stuttering severity, suggesting the involvement of cerebellum and OFC may underlie successful compensatory mechanisms by more fluent stutterers.

Decreased Cerebellar-Orbitofrontal Connectivity Correlates with Stuttering Severity: Whole-Brain Functional and Structural Connectivity Associations with Persistent Developmental Stuttering

Science.gov (United States)

Sitek, Kevin R.; Cai, Shanqing; Beal, Deryk S.; Perkell, Joseph S.; Guenther, Frank H.; Ghosh, Satrajit S.

2016-01-01

Persistent developmental stuttering is characterized by speech production disfluency and affects 1% of adults. The degree of impairment varies widely across individuals and the neural mechanisms underlying the disorder and this variability remain poorly understood. Here we elucidate compensatory mechanisms related to this variability in impairment using whole-brain functional and white matter connectivity analyses in persistent developmental stuttering. We found that people who stutter had stronger functional connectivity between cerebellum and thalamus than people with fluent speech, while stutterers with the least severe symptoms had greater functional connectivity between left cerebellum and left orbitofrontal cortex (OFC). Additionally, people who stutter had decreased functional and white matter connectivity among the perisylvian auditory, motor, and speech planning regions compared to typical speakers, but greater functional connectivity between the right basal ganglia and bilateral temporal auditory regions. Structurally, disfluency ratings were negatively correlated with white matter connections to left perisylvian regions and to the brain stem. Overall, we found increased connectivity among subcortical and reward network structures in people who stutter compared to controls. These connections were negatively correlated with stuttering severity, suggesting the involvement of cerebellum and OFC may underlie successful compensatory mechanisms by more fluent stutterers. PMID:27199712

Decreased cerebellar-orbitofrontal connectivity correlates with stuttering severity: Whole-brain functional and structural connectivity associations with persistent developmental stuttering

Directory of Open Access Journals (Sweden)

Kevin Richard Sitek

2016-05-01

Full Text Available Persistent developmental stuttering is characterized by speech production disfluency and affects 1% of adults. The degree of impairment varies widely across individuals and the neural mechanisms underlying the disorder and this variability remain poorly understood. Here, we elucidate compensatory mechanisms related to this variability in impairment using whole-brain functional and white matter connectivity analyses in persistent developmental stuttering. We found that people who stutter had stronger functional connectivity between cerebellum and thalamus than people with fluent speech, while stutterers with the least severe symptoms had greater functional connectivity between left cerebellum and left orbitofrontal cortex. Additionally, people who stutter had decreased functional and white matter connectivity among the perisylvian auditory, motor, and speech planning regions compared to typical speakers, but greater functional connectivity between the right basal ganglia and bilateral temporal auditory regions. Structurally, disfluency ratings were negatively correlated with white matter connections to left perisylvian regions and to the brain stem. Overall, we found increased connectivity among subcortical and reward network structures in people who stutter compared to controls. These connections were negatively correlated with stuttering severity, suggesting the involvement of cerebellum and orbitofrontal cortex may underlie successful compensatory mechanisms by more fluent stutterers.

Observations of Low-Frequency Magnetic Waves due to Newborn Interstellar Pickup Ions Using ACE, Ulysses, and Voyager Data

Science.gov (United States)

Smith, Charles W.; Aggarwal, Poornima; Argall, Matthew R.; Burlaga, Leonard F.; Bzowski, Maciej; Cannon, Bradford E.; Gary, S. Peter; Fisher, Meghan K.; Gilbert, Jason A.; Hollick, Sophia J.; Isenberg, Philip A.; Joyce, Colin J.; Murphy, Neil; Nuno, Raquel G.; Pine, Zackary B.; Richardson, John D.; Schwadron, Nathan A.; Skoug, Ruth M.; Sokół, Justyna M.; Taylor, David K.; Vasquez, Bernard J.

2017-09-01

Wave excitation by newborn interstellar pickup ions (PUIs) plays a significant role in theories that attempt to describe IBEX and Voyager observations in the solar wind and heliosheath. The same dynamic processes can be far-reaching and extend into the inner heliosphere to at least 1AU and likely to smaller heliocentric distances. While the high-resolution magnetic field measurements required to study these waves are not yet available in the heliosheath, we have studied a range of available observations and found evidence of waves due to interstellar PUIs using ACE (1998-2015 at 1 AU), Ulysses (1996-2006 at 2 to 5 AU, high and low latitudes) and Voyager (1978-1979 and 2 to 6 AU) observations. Efforts to extend the Voyager observations to 35 AU are ongoing. We have examined these data sets and report on observations of low-frequency waves that result from newborn interstellar pickup H+ and He+ ions. Although not as common as theory originally predicted, we presently have identified 524 independent occurrences. Our conclusion from studying these waves is that they are seen only when the ambient turbulence is sufficiently weak. The instability that generates these waves requires a slow accumulation of wave energy over several to tens of hours to achieve observable wave amplitudes. In regions where the turbulence is moderate to strong, the turbulence absorbs the wave energy before it can reach observable levels and transports the energy to the dissipation scales where it heats the background thermal particles. Only intervals with the weakest turbulence will permit energy accumulation over this time scale. These conditions are most often, but not exclusively, achieved in solar wind rarefaction regions.

Decreased expression of Sprouty2 in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder: a correlation with BDNF expression.

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Anilkumar Pillai

Full Text Available BACKGROUND: Current theories on the pathophysiology of schizophrenia suggest altered brain plasticity such as decreased neural proliferation and migration, delayed myelination, and abnormal synaptic modeling, in the brain of subjects with schizophrenia. Though functional alterations in BDNF, which plays important role in neuroplasticity, are implicated in many abnormalities found in schizophrenia, the regulatory mechanism(s involved in the abnormal signaling of BDNF in schizophrenia is not clear. The present study investigated whether Sprouty2, a regulator of growth factor signaling, is abnormally expressed in schizophrenia, and is associated with the changes in BDNF mRNA in this disorder. The potential effect of antipsychotic drugs on Sprouty2 expression was tested in adult rats. METHODS AND FINDINGS: Sprouty2 and BDNF gene expression were analyzed in dorsolateral prefrontal cortex samples from the Stanley Array Collection. Quantitative real-time PCR analysis of RNA in 100 individuals (35 with schizophrenia, 31 with bipolar disorder, and 34 psychiatrically normal controls showed significantly decreased expression of Sprouty2 and BDNF in both schizophrenia and bipolar disorder. Moreover, a significant correlation between these two genes existed in control, schizophrenia and bipolar subjects. Long-term treatment with antipsychotic drugs, haloperidol and olanzapine, showed differential effects on both Sprouty2 and BDNF mRNA and protein levels in the frontal cortex of rats. CONCLUSION: These findings demonstrating decreased expression of Sprouty2 associated with changes in BDNF, suggest the possibility that these decreases are secondary to treatment rather than to factors that are significant in the disease process of either schizophrenia and/or bipolar disorder. Further exploration of Sprouty2-related signal transduction pathways may be helpful to design novel treatment strategies for these disorders.

Decreased expression of GST pi is correlated with a poor prognosis in human esophageal squamous carcinoma

International Nuclear Information System (INIS)

Wang, Zhihui; He, Wei; Yang, Guanrui; Wang, Junsheng; Wang, Zhong; Nesland, Jahn M; Holm, Ruth; Suo, Zhenhe

2010-01-01

Glutathione S-transferase pi (GST pi) is a subgroup of GST family, which provides cellular protection against free radical and carcinogenic compounds due to its detoxifying function. Expression patterns of GST pi have been studied in several carcinomas and its down-regulation was implicated to be involved in malignant transformation in patients with Barrett's esophagus. However, neither the exact role of GST pi in the pathogenesis nor its prognostic impact in squamous esophageal carcinoma is fully characterized. Immunohistochemistry was used to investigate GST pi expression on 153 archival squamous esophageal carcinoma specimens with a GST pi monoclonal antibody. Statistic analyses were performed to explore its association with clinicopathological factors and clinical outcome. The GST pi expression was greatly reduced in tissues of esophageal carcinomas compared to adjacent normal tissues and residual benign tissues. Absent of GST pi protein expression in cytoplasm, nuclear and cytoplasm/nucleus was found in 51%, 64.7% and 48% of all the carcinoma cases, respectively. GST pi deficiency in cytoplasm, nucleus and cytoplasm/nucleus was significantly correlated to poor differentiation (p < 0.001, p < 0.001 and p < 0.001, respectively). UICC stage and T stage were found significantly correlated to negative expression of GST pi in cytoplasm (p < 0.001 and p = 0.004, respectively) and cytoplasm/nucleus (p = 0.017 and p = 0.031, respectively). In univariate analysis, absent of GST pi protein expression in cytoplasm, nucleus and cytoplasm/nucleus was significantly associated with a shorter overall survival (p < 0.001, p < 0.001 and p < 0.001, respectively), whereas only GST pi cytoplasmic staining retained an independent prognostic significance (p < 0.001) in multivariate analysis. Our results show that GST pi expression is down regulated in the squamous esophageal carcinoma, and that the lack of GST pi expression is associated with poor prognosis. Therefore

Uveitic secondary glaucoma: influence in James Joyce's (1882-1941) last works.

Science.gov (United States)

Ascaso, Francisco J; Bosch, Jordi

2010-02-01

James Joyce, considered one of the pre-eminent novelists of the 20th century, attained international renown with his work Ulysses. Its lack of standard punctuation makes it difficult to read. An example would be the famous non-punctuated 'Molly Bloom soliloquy' in the last chapter of Ulysses. Why is Joyce considered so difficult to read? He wrote and proofread Ulysses and Finnegans wake, his last works, during his battle against glaucoma, when his vision was seriously blurred. The distracting and confusing diacritical marks might be explained by Joyce's reduced visual acuity. Could Ulysses and Finnegans wake have been different if Joyce's visual problems had begun in the second rather than the first half of 20th century?

Delay in solar energetic particle onsets at high heliographic latitudes

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S. Dalla

2003-06-01

Full Text Available Ulysses observations have shown that solar energetic particles (SEPs can easily reach high heliographic latitudes. To obtain information on the release and propagation of SEPs prior to their arrival at Ulysses, we analyse the onsets of nine large high-latitude particle events. We measure the onset times in several energy channels, and plot them versus inverse particle speed. This allows us to derive an experimental path length and time of release from the solar atmosphere. We repeat the procedure for near-Earth observations by Wind and SOHO. We find that the derived path lengths at Ulysses are 1.06 to 2.45 times the length of a Parker spiral magnetic field line connecting the spacecraft to the Sun. The time of particle release from the Sun is between 100 and 350 min later than the release time derived from in-ecliptic measurements. We find no evidence of correlation between the delay in release and the inverse of the speed of the CME associated with the event, or the inverse of the speed of the corresponding interplanetary shock. The main parameter determining the magnitude of the delay appears to be the difference in latitude between the flare and the footpoint of the spacecraft.Key words. Interplanetary physics (energetic particles – Solar physics, astrophysics and astronomy (energetic particles, flares and mass ejections

Magnetic clouds seen at different locations in the heliosphere

Directory of Open Access Journals (Sweden)

L. Rodriguez

2008-02-01

Full Text Available We analyze two magnetic clouds (MCs observed in different points of the heliosphere. The main aim of the present study is to provide a link between the different aspects of this phenomenon, starting with information on the origins of the MCs at the Sun and following by the analysis of in-situ observations at 1 AU and at Ulysses. The candidate source regions were identified in SOHO/EIT and SOHO/MDI observations. They were correlated with H-α images that were obtained from ground-based observatories. Hints on the internal magnetic field configuration of the associated coronal mass ejections are obtained from LASCO C2 images. In interplanetary space, magnetic and plasma moments of the distribution function of plasma species (ACE/Ulysses were analyzed together with information on the plasma composition, and the results were compared between both spacecraft in order to understand how these structures interact and evolve in their cruise from the Sun to 5 AU. Additionally, estimates of global magnitudes of magnetic fluxes and helicity were obtained from magnetic field models applied to the data in interplanetary space. We have found that these magnetic characteristics were well kept from their solar source, up to 5 AU where Ulysses provided valuable information which, together with that obtained from ACE, can help to reinforce the correct matching of solar events and their interplanetary counterparts.

In-medium meson properties and screening correlators

International Nuclear Information System (INIS)

Bazavov, A; Karsch, F; Mukherjee, Swagato; Petreczky, P; Maezawa, Y

2014-01-01

We study spatial meson correlation functions consisting of strange quarks, strange and charm quarks and charm quarks in (2 + 1)-flavor QCD using the highly improved staggered quark action. We find that the in-medium modification of the meson correlators decreases with increasing charm quark content and decreasing size. In particular, we find strong in-medium modification of φ and D s meson correlators around the chiral transition temperature T c , while J/ψ and η c correlators show strong in-medium modification only at temperatures of 1.4T c .

Statins Decrease Oxidative Stress and ICD Therapies

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Heather L. Bloom

2010-01-01

Full Text Available Recent studies demonstrate that statins decrease ventricular arrhythmias in internal cardioverter defibrillator (ICD patients. The mechanism is unknown, but evidence links increased inflammatory and oxidative states with increased arrhythmias. We hypothesized that statin use decreases oxidation. Methods. 304 subjects with ICDs were surveyed for ventricular arrhythmia. Blood was analyzed for derivatives of reactive oxygen species (DROMs and interleukin-6 (IL-6. Results. Subjects included 252 (83% men, 58% on statins, 20% had ventricular arrhythmias. Average age was 63 years and ejection fraction (EF 20%. ICD implant duration was 29 ± 27 months. Use of statins correlated with lower ICD events (r=0.12, P=.02. Subjects on statins had lower hsCRP (5.2 versus 6.3; P=.05 and DROM levels (373 versus 397; P=.03. Other factors, including IL-6 and EF did not differ between statin and nonstatin use, nor did beta-blocker or antiarrhythmic use. Multivariate cross-correlation analysis demonstrated that DROMs, statins, IL-6 and EF were strongly associated with ICD events. Multivariate regression shows DROMs to be the dominant predictor. Conclusion. ICD event rate correlates with DROMs, a measure of lipid peroxides. Use of statins is associated with reduced DROMs and fewer ICD events, suggesting that statins exert their effect through reducing oxidation.

Radial correlation length measurements on ASDEX Upgrade using correlation Doppler reflectometry

International Nuclear Information System (INIS)

Schirmer, J; Conway, G D; Holzhauer, E; Suttrop, W; Zohm, H

2007-01-01

The technique of correlation Doppler reflectometry for providing radial correlation length L r measurements is explored in this paper. Experimental L r measurements are obtained using the recently installed dual channel Doppler reflectometer system on ASDEX Upgrade. The experimental measurements agree well with theory and with L r measured on other fusion devices using different diagnostic techniques. A strong link between L r and plasma confinement could be observed. From the L- to the H-mode, an increase in the absolute value of E r shear was detected at the same plasma edge region where a decrease in L r was measured. This observation is in agreement with theoretical models which predict that an increase in the absolute shear suppresses turbulent fluctuations in the plasma, leading to a reduction in L r . Furthermore, L r decreases from the plasma core to the edge and decreases with increasing plasma triangularity δ. The experimental results have been extensively modelled using a 2-dimensional finite difference time domain code. The simulations confirm that Doppler reflectometry provides robust radial correlation lengths of the turbulence with high resolution and suggests that L r is independent of the turbulence wavenumber k p erpendicular and its fluctuation level

A study of magnetic fluctuations and their anomalous scaling in the solar wind: the Ulysses fast-latitude scan

Directory of Open Access Journals (Sweden)

c. Pagel

2001-01-01

Full Text Available The solar wind is a highly turbulent and intermittent medium at frequencies between 10-4 and 10-1 Hz. Power spectra are used to look at fluctuations in the components of the magnetic field at high frequencies over a wide range of latitudes. Results show steady turbulence in the polar regions of the Sun and a more varied environment in the equatorial region. The magnetic field fluctuations exhibit anomalous scaling at high frequencies. Various models have been proposed in an attempt to better understand the scaling nature of such fluctuations in neutral fluid turbulence. We have used the Ulysses fast latitude scan data to perform a wide ranging comparison of three such models on the solar wind magnetic field data: the well-known P model, in both its Kolmogorov and Kraichnan forms, the lognormal cascade model and a model adapted from atmospheric physics, the G infinity model. They were tested by using fits to graphs of the structure function exponents g(q, by making a comparison with a non-linear measure of the deviation of g(q from the non-intermittent straight line, and by using extended self similarity technique, over a large range of helio-latitudes. Tests of all three models indicated a high level of intermittency in the fast solar wind, and showed a varied structure in the slow wind, with regions of apparently little intermittency next to regions of high intermittency, implying that the slow wind has no uniform origin. All but one of the models performed well, with the lognormal and Kolmogorov P model performing the best over all the tests, indicating that inhomogeneous energy transfer in the cascade is a good description. The Kraichnan model performed relatively poorly, and the overall results show that the Kraichnan model of turbulence is not well supported over the frequency and distance ranges of our data set. The G infinity model fitted the results surprisingly well and showed that there may very well be important universal geometrical

Use of research reactors for training and teaching nuclear sciences

International Nuclear Information System (INIS)

Safieh, J.; Gless, B.

2002-01-01

Training activities on reactors are organized by Cea on 2 specially dedicated reactors Ulysse (Saclay) and Siloette (Grenoble) and 2 research reactors Minerve (Cadarache) and Azur (Cadarache, facility managed by Technicatome). About 4000 students have been trained on Ulysse since its commissioning more than 40 years ago. The concept that led to the design of Ulysse was to build a true reactor dedicated to teaching and training activities and that was able to operate with great flexibility and under high conditions of safety, this reactor is inspired from the Argonaut-type reactor. The main specificities of Ulysse are: a nominal power of 100 kW, a maximal thermal neutron flux of 1.4 10 12 n.cm -2 .s -1 , a 90 % enriched fuel, a graphite reflector, the use of water as coolant and moderator, and 6 cadmium plates as control rods. Ulysse allows students to get practical experience on a large range of topics: approach to criticality, effect of the starting neutron source, calibration of control rods, distribution of the neutron flux in the thermal column, temperature coefficient, radiation detectors, neutron activation analysis, and radioprotection. (A.C.)

Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjogren's syndrome patients

DEFF Research Database (Denmark)

Castro, Isabel; Aguilera, Sergio; Brockhausen, Inka

2012-01-01

To determine the expression and enzymatic activities of sulphotransferases involved in mucin hyposulphation in labial salivary glands (LSGs) from SS patients and to correlate sulphotransferase activity with clinical parameters such as secretion, inflammation and serology....

Hyldest til almindeligheden

DEFF Research Database (Denmark)

Bøss, Michael

2005-01-01

James Joyces roman "Ulysses" handler om helt almindelige mennesker og har et demokratisk og humanistisk budskab af universel karakter. Udgivelsesdato: 19. august......James Joyces roman "Ulysses" handler om helt almindelige mennesker og har et demokratisk og humanistisk budskab af universel karakter. Udgivelsesdato: 19. august...

Characterization of SEP events at high heliographic latitudes

International Nuclear Information System (INIS)

Dalla, S.; Balogh, A.; Krucker, S.; Posner, A.; Mueller-Mellin, R.; Anglin, J.D.; Hofer, M.Y.; Marsden, R.G.; Sanderson, T.R.; Heber, B.; Zhang, M.; McKibben, R.B.

2003-01-01

Between February 2000 and May 2002, the Ulysses spacecraft made the first ever measurements of solar energetic particles (SEPs) at high heliographic latitudes. Nine large gradual SEP events were detected at latitudes greater than 45 deg., their signatures being clearest at high particle energies, i.e. protons >30 MeV and electrons >0.1 MeV. In this paper we measure the onset times of Ulysses high latitude events in several energy channels, and plot them versus inverse particle speed. We repeat the procedure for near Earth observations by Wind and SOHO. Velocity dispersion is observed in all the events near Earth and in most of them at Ulysses. The plots of onset times versus inverse speed allow to derive an experimental path length and time of release from the solar atmosphere. We find that the derived path lengths at Ulysses are longer than the length of a Parker spiral magnetic field line connecting it to the Sun, by a factor between 1.2-2.7. The time of particle release from the Sun is typically between 100 and 200 mins later than the release time derived from in-ecliptic measurements. Unlike near Earth observations, Ulysses measurements are therefore not compatible with scatter-free propagation from the Sun to the spacecraft

The solar wind in the third dimension

International Nuclear Information System (INIS)

Neugebauer, M.

1996-01-01

For many years, solar-wind physicists have been using plasma and field data acquired near the ecliptic plane together with data on the scintillation of radio sources and remote sensing of structures in the solar corona to estimate the properties of the high-latitude solar wind. Because of the highly successful Ulysses mission, the moment of truth is now here. This paper summarizes the principal agreements and differences between the Ulysses observations and expectations. The speed of the high-latitude solar wind was even greater than anticipated. The strength of the radial component of the interplanetary magnetic field was found to be independent of latitude. The tilt of the heliospheric current sheet caused reverse corotating shocks to be observed to higher latitudes than forward corotating shocks. The energetic particles accelerated in these shocks were detected well poleward of the latitudes at which Ulysses observed the interaction regions themselves. As anticipated, there was a strong flux of outward propagating Alfven waves throughout the polar flow. Those waves were probably largely responsible for the smaller-than-anticipated increase of galactic cosmic rays with increasing latitude. As expected, the charge state or ionization temperature of heavy ions was lower in the polar flow than in low-latitude interstream flows. What was not anticipated was the correlation of elemental abundances with ionization temperatures; the Ulysses data revealed a connection between the first ionization time in the upper chromosphere and the final ionization state in the corona. As expected, transient events were detected to ∼60 deg. latitude, but the properties of those high latitude transient flows held some surprises. At high latitudes, the speeds of the transient interplanetary plasma clouds were approximately the same as the speed of the ambient plasma and the expansion of the clouds drove forward and reverse shock pairs that had never been seen at low latitudes. At high

Congruent, decreasing trends of gentoo penguins and Crozet shags ...

African Journals Online (AJOL)

Numbers of gentoo penguins Pygoscelis papua and Crozet shags Phalacrocorax [atriceps] melanogenis breeding annually at Marion Island, one of South Africa's Prince Edward Islands in the South-West Indian Ocean, were strongly correlated over 19 split-years from 1994/1995 to 2012/2013. Both species decreased ...

Decreased medial prefrontal cortex activation during self-referential processing in bipolar mania.

Science.gov (United States)

Herold, Dorrit; Usnich, Tatiana; Spengler, Stephanie; Sajonz, Bastian; Bauer, Michael; Bermpohl, Felix

2017-09-01

Patients with bipolar disorder in mania exhibit symptoms pointing towards altered self-referential processing, such as decreased self-focus, flight of ideas and high distractibility. In depression, the opposite pattern of symptoms has been connected to increased activation of medial prefrontal cortex (mPFC) during self-referential processing. In this study, we hypothesized that (1) patients with mania will exhibit decreased activation in the mPFC during self-referential processing and (2) will be more alexithymic and that levels of alexithymia will correlate negatively with mPFC activation. The neural response to standardized pictures was compared in 14 patients with bipolar I disorder in mania to 14 healthy controls using blood oxygen level dependent contrast magnetic resonance imaging. Participants were asked to indicate with button press during the scanning session for each picture whether the pictures personally related to them or not. Toronto alexithymia scale (TAS) scores were recorded from all participants. In the group analysis, patients with mania exhibited decreased activation in a predefined region of interest in the mPFC during self-referential processing compared to healthy controls. Patients with mania showed significantly higher levels of alexithymia, attributable to difficulties in identifying and describing emotions. Activation in the mPFC correlated negatively with levels of alexithymia. Results presented here should be replicated in a larger group, potentially including unmedicated patients. The finding of decreased mPFC activation during self-referential processing in mania may reflect decreased self-focus and high distractibility. Support for this view comes from the negative correlation between higher alexithymia scores and decreased mPFC activation. These findings represent an opposite clinical and neuroimaging pattern to findings in depression. Copyright © 2017. Published by Elsevier B.V.

Defected red blood cell membranes and direct correlation with the uraemic milieu: the connection with the decreased red blood cell lifespan observed in haemodialysis patients

International Nuclear Information System (INIS)

Stamopoulos, D; Manios, E; Gogola, V; Grapsa, E; Bakirtzi, N

2012-01-01

Together with impaired production of erythropoietin and iron deficiency, the decreased lifespan of red blood cells (RBCs) is a main factor contributing to the chronic anaemia observed in haemodialysis (HD) patients. Atomic force microscopy is employed in this work to thoroughly survey the membrane of intact RBCs (iRBCs) of HD patients in comparison to those of healthy donors, aiming to obtain direct information on the structural status of RBCs that can be related to their decreased lifespan. We observed that the iRBC membrane of the HD patients is overpopulated with extended circular defects, termed ‘orifices’, that have typical dimension ranging between 0.2 and 1.0 μm. The ‘orifice’ index—that is, the mean population of ‘orifices’ per top membrane surface—exhibits a pronounced relative increase of order 54 ± 12% for the HD patients as compared to healthy donors. Interestingly, for the HD patients, the ‘orifice’ index, which relates to the structural status of the RBC membrane, correlates strongly with urea concentration, which is a basic index of the uraemic milieu. Thus, these results indicate that the uraemic milieu downgrades the structural status of the RBC membrane, possibly triggering biochemical processes that result in their premature elimination from the circulation. This process could decrease the lifespan of RBCs, as observed in HD patients. (paper)

Decreased expression of GST pi is correlated with a poor prognosis in human esophageal squamous carcinoma

Directory of Open Access Journals (Sweden)

Wang Junsheng

2010-07-01

Full Text Available Abstract Background Glutathione S-transferase pi (GST pi is a subgroup of GST family, which provides cellular protection against free radical and carcinogenic compounds due to its detoxifying function. Expression patterns of GST pi have been studied in several carcinomas and its down-regulation was implicated to be involved in malignant transformation in patients with Barrett's esophagus. However, neither the exact role of GST pi in the pathogenesis nor its prognostic impact in squamous esophageal carcinoma is fully characterized. Methods Immunohistochemistry was used to investigate GST pi expression on 153 archival squamous esophageal carcinoma specimens with a GST pi monoclonal antibody. Statistic analyses were performed to explore its association with clinicopathological factors and clinical outcome. Results The GST pi expression was greatly reduced in tissues of esophageal carcinomas compared to adjacent normal tissues and residual benign tissues. Absent of GST pi protein expression in cytoplasm, nuclear and cytoplasm/nucleus was found in 51%, 64.7% and 48% of all the carcinoma cases, respectively. GST pi deficiency in cytoplasm, nucleus and cytoplasm/nucleus was significantly correlated to poor differentiation (p p p p p = 0.004, respectively and cytoplasm/nucleus (p = 0.017 and p = 0.031, respectively. In univariate analysis, absent of GST pi protein expression in cytoplasm, nucleus and cytoplasm/nucleus was significantly associated with a shorter overall survival (p p p p Conclusions Our results show that GST pi expression is down regulated in the squamous esophageal carcinoma, and that the lack of GST pi expression is associated with poor prognosis. Therefore, deficiency of GST pi protein expression may be an important mechanism involved in the carcinogenesis and progression of the squamous esophageal carcinoma, and the underlying mechanisms leading to decreased GST pi expression deserve further investigation.

Correlation of angina pectoris and perfusion decrease by collateral circulation in single-vessel coronary chronic total occlusion using myocardial perfusion single-photon emssion computed tomography

Energy Technology Data Exchange (ETDEWEB)

Cho, Sang Geon; Park, Ki Seong; Kang, Sae Ryung [Chonnam National University Hospital, Gwangju (Korea, Republic of); and others

2016-03-15

To evaluate the perfusion decrease in donor myocardium by collateral circulation and its correlation with angina pectoris in patients with chronic total occlusion (CTO) using myocardial perfusion single-photon emission computed tomography (MPS). Thirty-six patients with single-vessel CTO without any other stenosis were included. All patients underwent MPS and coronary angiography (CAG) within 2 months. Total 72 donor arteries were evaluated for the grades of collaterals to the CTO artery using the Rentrop grading system on CAG. Perfusion defects and perfusion scores in donor and CTO territories were analyzed on MPS. Myocardial perfusion of donor and CTO territories were evaluated according to the presence of angina pectoris and the grades of collateral circulation. When the CTO territory was ischemic, symptomatic patients showed higher summed difference scores in the CTO territory compared to asymptomatic patients (3.5 ± 2.4 vs. 1.5 ± 0.8 for symptomatic and asymptomatic groups respectively; p = 0.034). However, when the CTO territory was nonischemic, symptomatic patients showed higher summed stress scores (SSS, 4.3 ± 2.9 vs. 1.6 ± 1.2; p = 0.032) and summed rest scores (SRS, 4.2 ± 2.5 vs. 1.5 ± 1.1; p = 0.003) in the donor territories. On the per-vessel analysis, perfusion defects in donor territories were more frequent (0 % vs. 53 % vs. 86 % for Rentrop 0, Rentrop 1–2 and Rentrop 3, respectively; p < 0.001) and showed higher SSS (0.0 ± 0.0, 1.3 ± 1.6 and 2.1 ± 1.1 for Rentrop 0, Rentrop 1–2 and Rentrop 3, respectively; p = 0.001) and SRS (0.0 ± 0.0, 1.0 ± 1.4 and 1.7 ± 1.2; p = 0.003) at higher Rentrop grades, but their patterns were variable. Angina pectoris was related to either ischemia of the myocardium beyond CTO or a perfusion decrease in the donor myocardium. The perfusion decrease in donor myocardium positively correlated with the collateral grades.

Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D-Deficient Women with PCOS: A Randomized Placebo-Controlled Trial.

Science.gov (United States)

Irani, Mohamad; Seifer, David B; Grazi, Richard V; Irani, Sara; Rosenwaks, Zev; Tal, Reshef

2017-03-28

Vascular endothelial growth factor (VEGF) has been suggested to play a role in the pathophysiology of polycystic ovary syndrome (PCOS) and may contribute to increased risk of ovarian hyperstimulation syndrome (OHSS) in affected individuals. Vitamin D (VitD) supplementation improves multiple clinical parameters in VitD-deficient women with PCOS and decreases VEGF levels in several other pathologic conditions. Unveiling the basic mechanisms underlying the beneficial effects of vitamin D on PCOS may enhance our understanding of the pathophysiology of this syndrome. It may also suggest a new treatment for PCOS that can improve it through the same mechanism as vitamin D and can be given regardless of vitamin D levels. Therefore, we aimed to explore the effect of VitD supplementation on serum VEGF levels and assess whether changes in VEGF correlate with an improvement in characteristic clinical abnormalities of PCOS. This is a randomized placebo-controlled trial conducted between October 2013 and March 2015. Sixty-eight VitD-deficient women with PCOS were recruited. Women received either 50,000 IU of oral VitD3 or placebo once weekly for 8 weeks. There was a significant decrease in serum VEGF levels (1106.4 ± 36.5 to 965.3 ± 42.7 pg·mL -1 ; p PCOS. This is a novel molecular explanation for the beneficial effects of VitD treatment. It also suggests the need to investigate a potential role of VitD treatment in reducing the incidence or severity of OHSS in VitD-deficient women with PCOS.

First Person Past: American Autobiographies, volume 1

DEFF Research Database (Denmark)

United States, literature, Benjamin Franklin, Olaudah Equino, Davy Crockett, Black Hawk, Harriet Robinson, Frederick Douglass, Harriet Jacobs, Elizabeth Cady Stanton, Ulysses S. Grant, Tunis Gulic Campbell......United States, literature, Benjamin Franklin, Olaudah Equino, Davy Crockett, Black Hawk, Harriet Robinson, Frederick Douglass, Harriet Jacobs, Elizabeth Cady Stanton, Ulysses S. Grant, Tunis Gulic Campbell...

Pairing correlations in N ∝Z pf-shell nuclei

International Nuclear Information System (INIS)

Langanke, K.; Dean, D.J.; Koonin, S.E.; Radha, P.B.

1997-01-01

We perform shell model Monte Carlo calculations to study pair correlations in the ground states of N=Z nuclei with masses A=48-60. We find that T=1, J π =0 + proton-neutron correlations play an important, and even dominant role, in the ground states of odd-odd N=Z nuclei, in agreement with experiment. By studying pairing in the ground states of 52-58 Fe, we observe that the isovector proton-neutron correlations decrease rapidly with increasing neutron excess. In contrast, both the proton, and trivially the neutron correlations increase as neutrons are added. We also study the thermal properties and the temperature dependence of pair correlations for 50 Mn and 52 Fe as exemplars of odd-odd and even-even N=Z nuclei. While for 52 Fe results are similar to those obtained for other even-even nuclei in this mass range, the properties of 50 Mn at low temperatures are strongly influenced by isovector neutron-proton pairing. In coexistence with these isovector pair correlations, our calculations also indicate an excess of isoscalar proton-neutron pairing over the mean-field values. The isovector neutron-proton correlations rapidly decrease with temperatures and vanish for temperatures above T=700 keV, while the isovector correlations among like-nucleons persist to higher temperatures. Related to the quenching of the isovector proton-neutron correlations, the average isospin decreases from 1, appropriate for the ground state, to 0 as the temperature increases. (orig.)

Imprints from the solar cycle on the helium atom and helium pickup ion distributions

Directory of Open Access Journals (Sweden)

D. Rucinski

Full Text Available Neutral interstellar helium atoms penetrate into the solar system almost unaffected by gas–plasma interactions in the heliospheric interface region, and thus can be considered as carriers of original information on the basic parameters (like density, temperature, bulk velocity of the Very Local Interstellar Medium (VLISM. Such information can nowadays be derived from analysis of data obtained from different experimental methods: in situ measurements of He atoms (Ulysses, observations of the solar backscattered He 584 A radiation (EUVE, in situ measurements of He + pickup ions (AMPTE, Ulysses, Wind, SOHO, ACE. In view of the current coordinated international ISSI campaign devoted to the study of the helium focusing cone structure and its evolution, we analyze expected variations of neutral He density, of He + pickup fluxes and of their phase space distributions at various phases of the solar activity cycle based on a realistic time-dependent modelling of the neutral helium and He + pickup ion distributions, which reflect solar cycle-induced variations of the photoionization rate. We show that the neutral helium density values are generally anticorrelated with the solar activity phase and in extreme cases (near the downwind axis the maximum-to-minimum density ratio may even exceed factors of ~ 3 at 1 AU. We also demonstrate that in the upwind hemisphere (at 1 AU and beyond the He + fluxes are correlated with the solar cycle activity, whereas on the downwind side the maximum of the expected flux up to distances of ~ 3 AU occurs around solar minimum epoch, and only further away does the correlation with solar activity become positive. Finally, we present the response of the phase space distribution spectra of He + pickup ions (in the solar wind frame for different epochs of the solar cycle and heliocentric distances from 1 to 5 AU covering the range of Ulysses, Wind and ACE observations.

Key words. Solar physics, astrophysics and astronomy

Imprints from the solar cycle on the helium atom and helium pickup ion distributions

Directory of Open Access Journals (Sweden)

D. Rucinski

2003-06-01

Full Text Available Neutral interstellar helium atoms penetrate into the solar system almost unaffected by gas–plasma interactions in the heliospheric interface region, and thus can be considered as carriers of original information on the basic parameters (like density, temperature, bulk velocity of the Very Local Interstellar Medium (VLISM. Such information can nowadays be derived from analysis of data obtained from different experimental methods: in situ measurements of He atoms (Ulysses, observations of the solar backscattered He 584 A radiation (EUVE, in situ measurements of He + pickup ions (AMPTE, Ulysses, Wind, SOHO, ACE. In view of the current coordinated international ISSI campaign devoted to the study of the helium focusing cone structure and its evolution, we analyze expected variations of neutral He density, of He + pickup fluxes and of their phase space distributions at various phases of the solar activity cycle based on a realistic time-dependent modelling of the neutral helium and He + pickup ion distributions, which reflect solar cycle-induced variations of the photoionization rate. We show that the neutral helium density values are generally anticorrelated with the solar activity phase and in extreme cases (near the downwind axis the maximum-to-minimum density ratio may even exceed factors of ~ 3 at 1 AU. We also demonstrate that in the upwind hemisphere (at 1 AU and beyond the He + fluxes are correlated with the solar cycle activity, whereas on the downwind side the maximum of the expected flux up to distances of ~ 3 AU occurs around solar minimum epoch, and only further away does the correlation with solar activity become positive. Finally, we present the response of the phase space distribution spectra of He + pickup ions (in the solar wind frame for different epochs of the solar cycle and heliocentric distances from 1 to 5 AU covering the range of Ulysses, Wind and ACE observations.Key words. Solar physics, astrophysics and astronomy

High accurate volume holographic correlator with 4000 parallel correlation channels

Science.gov (United States)

Ni, Kai; Qu, Zongyao; Cao, Liangcai; Su, Ping; He, Qingsheng; Jin, Guofan

2008-03-01

Volume holographic correlator allows simultaneously calculate the two-dimensional inner product between the input image and each stored image. We have recently experimentally implemented in VHC 4000 parallel correlation channels with better than 98% output accuracy in a single location in a crystal. The speckle modulation is used to suppress the sidelobes of the correlation patterns, allowing more correlation spots to be contained in the output plane. A modified exposure schedule is designed to ensure the hologram in each channel with unity diffraction efficiency. In this schedule, a restricted coefficient was introduced into the original exposure schedule to solve the problem that the sensitivity and time constant of the crystal will change as a time function when in high-capacity storage. An interleaving method is proposed to improve the output accuracy. By unifying the distribution of the input and stored image patterns without changing the inner products between them, this method could eliminate the impact of correlation pattern variety on calculated inner product values. Moreover, by using this method, the maximum correlation spot size is reduced, which decreases the required minimum safe clearance between neighboring spots in the output plane, allowing more spots to be parallely detected without crosstalk. The experimental results are given and analyzed.

The decrease of mineralcorticoid receptor drives angiogenic pathways in colorectal cancer.

Directory of Open Access Journals (Sweden)

Laura Tiberio

Full Text Available Angiogenesis plays a crucial role in tumor growth and progression. Low expression of mineralocorticoid receptor (MR in several malignant tumors correlates with disease recurrence and overall survival. Previous studies have shown that MR expression is decreased in colorectal cancer (CRC. Here we hypothesize that decreased MR expression can contribute to angiogenesis and poor patient survival in colorectal malignancies. In a cohort of CRC patients, we analyzed tumor MR expression, its correlation with tumor microvascular density and its impact on survival. Subsequently, we interrogated the role of MR in angiogenesis in an in vitro model, based on the colon cancer cell line HCT116, ingenierized to re-express a physiologically controlled MR. In CRC, decreased MR expression was associated with increased microvascular density and poor patient survival. In pchMR transfected HCT116, aldosterone or natural serum steroids largely inhibited mRNA expression levels of both VEGFA and its receptor 2/KDR. In CRC, MR activation may significantly decrease angiogenesis by directly inhibiting dysregulated VEGFA and hypoxia-induced VEGFA mRNA expression. In addition, MR activation attenuates the expression of the VEGF receptor 2/KDR, possibly dampening the activation of a VEGFA/KDR dependent signaling pathway important for the survival of tumor cells under hypoxic conditions.

Plasma prolactin and homovanillic acid as markers for psychopathology and abnormal movements after neuroleptic dose decrease.

Science.gov (United States)

Newcomer, J W; Riney, S J; Vinogradov, S; Csernansky, J G

1992-01-01

Plasma prolactin concentration (pPRL), plasma homovanillic acid concentration (pHVA), and symptomatology were measured in 24 male subjects with schizophrenia during maintenance haloperidol treatment. Fourteen subjects subsequently underwent 50 percent dose decreases under placebo-controlled, double-blind conditions. At baseline, a significant inverse correlation was found between pPRL and both tardive dyskinesia (TD) and "thinking disorder"; pPRL was directly correlated with negative symptoms. No such relationship was found with pHVA. In the patients who underwent a dose decrease, no relationship was found between baseline pPRL or pHVA and any clinical variable after the decrease. These data do not support the use of baseline pPRL or pHVA as markers of central dopamine function subsequent to a neuroleptic dose decrease.

Solar winds along curved magnetic field lines

OpenAIRE

Li, Bo; Xia, Li-Dong; Chen, Yao

2011-01-01

Both remote-sensing measurements using the interplanetary scintillation (IPS) technique and in situ measurements by the Ulysses spacecraft show a bimodal structure for the solar wind at solar minimum conditions. At present what makes the fast wind fast and the slow wind slow still remains to be answered. While a robust empirical correlation exists between the coronal expansion rate $f_c$ of the flow tubes and the speeds $v$ measured in situ, further data analysis suggests that $v$ depends on ...

Observations from 1 to 6 AU of Low-Frequency Magnetic Waves due to Newborn Interstellar Pickup Ions Using Ulysses, Voyager and ACE Data

Science.gov (United States)

Smith, C. W.; Aggarwal, P.; Argall, M. R.; Burlaga, L. F.; Bzowski, M.; Cannon, B. E.; Gary, S. P.; Fisher, M. K.; Gilbert, J. A.; Hollick, S. J.; Isenberg, P. A.; Joyce, C. J.; Murphy, N.; Nuno, R. G.; Pine, Z. B.; Richardson, J. D.; Schwadron, N.; Skoug, R. M.; Sokol, J. M.; Taylor, D. K.; Vasquez, B. J.; Zurbuchen, T.

2016-12-01

Wave excitation by newborn interstellar pickup ions (PUIs) play a significant role in theories that attempt to describe IBEX and Voyager observations in the heliosheath as well as solar wind heating. The same dynamic processes can be far-reaching and extend into the inner heliosphere to at least 1AU and likely to smaller heliocentric distances. While the high-resolution magnetic field measurements required to study these waves are not yet available in the heliosheath, we have studied a range of available observations and found evidence of waves due to interstellar PUIs using ACE (1998-2015 at 1 AU), Ulysses (1996-2006 at 2 to 5 AU, high and low latitudes) and Voyager (1978-1979 and 2 to 6 AU) observations. Efforts to extend the Voyager observations to 35 AU are ongoing. We have examined these data sets and report on observations of low-frequency waves that result from newborn interstellar pickup H+ and He+ ions. Although not as common as theory once predicted, we presently have identified 524 independent occurrences. Our conclusion from studying these waves is that they are seen only when the ambient turbulence is sufficiently weak. The instability that leads to the generation of these waves requires a slow accumulation of wave energy over several to tens of hours to achieve the observed wave amplitudes. In regions where the turbulence is moderate to strong, the turbulence consumes the wave energy before it can reach observable levels and transports the energy to the dissipation scales where it heats the background thermal particles. Only intervals with the weakest turbulence will permit energy accumulation over this time scale. These conditions are most often, but not exclusively, achieved in solar wind rarefaction regions.

Interference Correlations of Hyperons in Neutron-Carbon Interactions

CERN Document Server

Aleev, A N; Balandin, V P; Bulekov, O V; Eremin, S V; Geshkov, I M; Goudzovski, E A; Grigalashvili, T S; Guriev D K; Ivanchenko, I M; Ivanchenko, Z M; Kekelidze, V D; Khristov, P Z; Kopadze, M V; Kosarev, I G; Kozhenkova, Z I; Kuzmin, N A; Kvatadze, R A; Ljubimov, A L; Loktionov, A A; Lomidze, N L; Madigozhin, D T; Maznyj, V G; Mitsyn, V V; Molokanova, N A; Morozov, A N; Pismenyj, R E; Polenkevich, I A; Ponosov, A K; Ponta, T; Potrebenikov, Yu K; Sergeev, F M; Slepets, L A; Spaskov, V N; Zinchenko, A I

2003-01-01

The interference correlations of \\Lambda-hyperon pairs produced on the carbon target by 20-70 GeV neutrons have been investigated with the EXCHARM spectrometer. Destructive correlations at low relative 4-momenta are observed for \\Lambda\\Lambda-pairs. No correlations of this type are observed for \\Lambda\\bar{\\Lambda}. Comparison with the corresponding data on meson correlations shows a decrease of production area sizes with an increase of particle masses.

Cerebral hematocrit decreases with hemodynamic compromise in carotid artery occlusion: a PET study.

Science.gov (United States)

Yamauchi, H; Fukuyama, H; Nagahama, Y; Katsumi, Y; Okazawa, H

1998-01-01

This study investigated whether in patients with internal carotid artery occlusion the regional cerebral hematocrit correlates with cerebral hemodynamics or metabolic state and, if so, how the regional cerebral hematocrit changes in the hemodynamically compromised region. We used positron emission tomography to study seven patients with unilateral internal carotid artery occlusion and no cortical infarction in the chronic stage. The distributions of red blood cell and plasma volumes were assessed using oxygen-15-labeled carbon monoxide and copper-62-labeled human serum albumin-dithiosemicarbazone tracers, respectively. The calculated hematocrit value was compared with the hemodynamic and metabolic parameters measured with the oxygen-15 steady-state technique. In the cerebral cortex, the value of the cerebral hematocrit varied but was correlated with the hemodynamic and metabolic status. Stepwise regression analysis revealed that the large vessel hematocrit, the cerebral metabolic rate of oxygen, and the cerebral blood flow or the oxygen extraction fraction accounted for a significant proportion of variance of the cerebral hematocrit. The oxygen extraction fraction and the cerebral metabolic rate of oxygen negatively correlated with the cerebral hematocrit, whereas the cerebral blood flow correlated positively: patients with reduced blood supply relative to metabolic demand (decreased blood flow with increased oxygen extraction fraction) showed low hematocrit values. In carotid artery occlusion in the chronic stage, regional cerebral hematocrit may vary according to cerebral hemodynamics and metabolic status. Regional cerebral hematocrit may decrease with hemodynamic compromise unless oxygen metabolism concomitantly decreases.

Squeezed fermions and back-to-back correlations

International Nuclear Information System (INIS)

Panda, P.K.; Krein, G.; Padula, S.S.; Csoergoe, T.; Hama, Y.

2001-01-01

Back-to-back correlations of asymptotic fermion pairs appear if in-medium interactions lead to mass modifications of fermion states in a thermalized medium. The back-to-back correlations of protons and anti-protons will be experimentally observable in ultrarelativistic heavy ion collisions. The strength of back-to-back correlations of fermions can be unlimitedly large, diverging as the momentum of the pair increases and the net baryon density decreases. (author)

Squeezed fermions and back-to-back correlations

Energy Technology Data Exchange (ETDEWEB)

Panda, P.K.; Krein, G.; Padula, S.S. [Instituto de Fisica Teorica (IFT), Sao Paulo, SP (Brazil); Csoergoe, T. [Hungarian Academy of Sciences, Budapest (Hungary). Research Institute for Particle and Nuclear Physics (RMKI, KFKI); Hama, Y. [Sao Paulo Univ., SP (Brazil). Inst. de Fisica

2001-07-01

Back-to-back correlations of asymptotic fermion pairs appear if in-medium interactions lead to mass modifications of fermion states in a thermalized medium. The back-to-back correlations of protons and anti-protons will be experimentally observable in ultrarelativistic heavy ion collisions. The strength of back-to-back correlations of fermions can be unlimitedly large, diverging as the momentum of the pair increases and the net baryon density decreases. (author)

Study of morphological changes in scattering and optically anisotropic medium through correlation images

Science.gov (United States)

Jain, Neha; Shukla, Prashant; Singh, Jai

2018-05-01

Correlation images are very useful in determining the morphological changes. We have investigated the correlation image analysis on depolarization and retardance matrices of polystyrene and gelatine samples respectively. We observed that that correlation images have a potential to show a significant variation with change in the concentration of samples (polystyrene and gelatine). For polystyrene microspheres the correlation value decreases with increasing scattering coefficient. In gelatine samples the correlation also decreases with sample concentration. This variation in correlation for retardance shows the change in a birefringence property of gelatine solution.

Detrended cross-correlation analysis of electroencephalogram

International Nuclear Information System (INIS)

Wang Jun; Zhao Da-Qing

2012-01-01

In the paper we use detrended cross-correlation analysis (DCCA) to study the electroencephalograms of healthy young subjects and healthy old subjects. It is found that the cross-correlation between different leads of a healthy young subject is larger than that of a healthy old subject. It was shown that the cross-correlation relationship decreases with the aging process and the phenomenon can help to diagnose whether the subject's brain function is healthy or not. (interdisciplinary physics and related areas of science and technology)

Two-proton correlation functions in nuclear reactions

International Nuclear Information System (INIS)

Verde, G.

2001-01-01

Full text: Proton-proton correlation functions can be used to study the space-time characteristics of nuclear reactions. For very short-lived sources, the maximum value of the correlation at 20 MeV/c, due to the attractive nature of the S-wave phase shift, provides a unique measure of the size of the emitting source. For long-lived sources, the height of this maximum depends, in addition, on the life time of the source. In this talk, we investigate the common reaction scenario involving both fast dynamical as well as slower emissions from evaporation and/or secondary decays of heavy fragments. We show that the maximum at 20 MeV/c depends both on the source dimension and on the fraction of coincident proton pairs produced in the early stage of the reaction, dominated by fast dynamical preequilibrium emission. The width of the peak at 20 MeV/c, on the other hand, is uniquely correlated to the size of the source. Hence, the size of the emitting source must be extracted from the width or, even better, from the entire shape of the correlation peak, and not from the height. By numerically inverting the measured correlation function, we show that existing data determine only the shape of the fast dynamical source and that its size changes little with proton momenta, contrary to previous analyses with Gaussian sources of zero-lifetime. We further show that the well documented dramatic decrease in the correlation maximum with decreasing total proton momentum reflects directly a corresponding decrease in the fraction of contributing proton pairs from preequilibrium emissions. This provides a powerful method to decompose the proton spectrum into a fraction that originates from fast dynamical emission and a complimentary fraction that originates from slower evaporative emission or secondary decays. We discuss also the comparison of such correlations to transport theories and the generalizations of these techniques to correlations between composite particles. Such studies can

Intershell correlations in photoionization of outer shells

Energy Technology Data Exchange (ETDEWEB)

Amusia, M.Ya. [The Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel); A.F. Ioffe Physical-Technical Institute, St. Petersburg 194021 (Russian Federation); Chernysheva, L.V. [A.F. Ioffe Physical-Technical Institute, St. Petersburg 194021 (Russian Federation); Drukarev, E.G. [National Research Center “Kurchatov Institute”, Konstantinov Petersburg Nuclear Physics Institute, St. Petersburg 188300 (Russian Federation)

2016-02-15

We demonstrate that the cross sections for photoionization of the outer shells are noticeably modified at the photon energies close to the thresholds of ionization of the inner shells due to correlations with the latter. The correlations may lead to increase or to decrease of the cross sections just above the ionization thresholds.

Intershell correlations in photoionization of outer shells

International Nuclear Information System (INIS)

Amusia, M.Ya.; Chernysheva, L.V.; Drukarev, E.G.

2016-01-01

We demonstrate that the cross sections for photoionization of the outer shells are noticeably modified at the photon energies close to the thresholds of ionization of the inner shells due to correlations with the latter. The correlations may lead to increase or to decrease of the cross sections just above the ionization thresholds.

Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid.

Science.gov (United States)

Ju, Yo-El S; Finn, Mary Beth; Sutphen, Courtney L; Herries, Elizabeth M; Jerome, Gina M; Ladenson, Jack H; Crimmins, Daniel L; Fagan, Anne M; Holtzman, David M

2016-07-01

We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and increased amyloid-β. Polysomnography and lumbar puncture were performed in OSA and control groups. SWA negatively correlated with cerebrospinal fluid (CSF) amyloid-β-40 among controls and was decreased in the OSA group. Unexpectedly, amyloid-β-40 was decreased in the OSA group. Other neuronally derived proteins, but not total protein, were also decreased in the OSA group, suggesting that OSA may affect the interaction between interstitial and cerebrospinal fluid. Ann Neurol 2016;80:154-159. © 2016 American Neurological Association.

MODULATION OF GALACTIC COSMIC RAYS OBSERVED AT L1 IN SOLAR CYCLE 23

Energy Technology Data Exchange (ETDEWEB)

Fludra, A., E-mail: Andrzej.Fludra@stfc.ac.uk [RAL Space, STFC Rutherford Appleton Laboratory, Harwell, Didcot OX11 0QX (United Kingdom)

2015-01-20

We analyze a unique 15 yr record of galactic cosmic-ray (GCR) measurements made by the SOHO Coronal Diagnostic Spectrometer NIS detectors, recording integrated GCR numbers with energies above 1.0 GeV between 1996 July and 2011 June. We are able to closely reproduce the main features of the SOHO/CDS GCR record using the modulation potential calculated from neutron monitor data by Usoskin et al. The GCR numbers show a clear solar cycle modulation: they decrease by 50% from the 1997 minimum to the 2000 maximum of the solar cycle, then return to the 1997 level in 2007 and continue to rise, in 2009 December reaching a level 25% higher than in 1997. This 25% increase is in contrast with the behavior of Ulysses/KET GCR protons extrapolated to 1 AU in the ecliptic plane, showing the same level in 2008-2009 as in 1997. The GCR numbers are inversely correlated with the tilt angle of the heliospheric current sheet. In particular, the continued increase of SOHO/CDS GCRs from 2007 until 2009 is correlated with the decrease of the minimum tilt angle from 30° in mid-2008 to 5° in late 2009. The GCR level then drops sharply from 2010 January, again consistent with a rapid increase of the tilt angle to over 35°. This shows that the extended 2008 solar minimum was different from the 1997 minimum in terms of the structure of the heliospheric current sheet.

Relationship between cognitive function and prevalence of decrease in intrinsic academic motivation in adolescents

Science.gov (United States)

2011-01-01

Background Decrease in intrinsic motivation is a common complaint among elementary and junior high school students, and is related to poor academic performance. Since grade-dependent development of cognitive functions also influences academic performance by these students, we examined whether cognitive functions are related to the prevalence of decrease in intrinsic academic motivation. Methods The study group consisted of 134 elementary school students from 4th to 6th grades and 133 junior high school students from 7th to 9th grades. Participants completed a questionnaire on intrinsic academic motivation. They also performed paper-and-pencil and computerized cognitive tests to measure abilities in motor processing, spatial construction, semantic fluency, immediate memory, short-term memory, delayed memory, spatial working memory, and selective, alternative, and divided attention. Results In multivariate logistic regression analyses adjusted for grade and gender, scores of none of the cognitive tests were correlated with the prevalence of decrease in intrinsic academic motivation in elementary school students. However, low digit span forward test score and score for comprehension of the story in the kana pick-out test were positively correlated with the prevalence of decrease in intrinsic academic motivation in junior high school students. Conclusions The present findings suggest that decrease in capacity for verbal memory is associated with the prevalence of decrease in intrinsic academic motivation among junior high school students. PMID:21235802

Relationship between cognitive function and prevalence of decrease in intrinsic academic motivation in adolescents

Directory of Open Access Journals (Sweden)

Fukuda Sanae

2011-01-01

Full Text Available Abstract Background Decrease in intrinsic motivation is a common complaint among elementary and junior high school students, and is related to poor academic performance. Since grade-dependent development of cognitive functions also influences academic performance by these students, we examined whether cognitive functions are related to the prevalence of decrease in intrinsic academic motivation. Methods The study group consisted of 134 elementary school students from 4th to 6th grades and 133 junior high school students from 7th to 9th grades. Participants completed a questionnaire on intrinsic academic motivation. They also performed paper-and-pencil and computerized cognitive tests to measure abilities in motor processing, spatial construction, semantic fluency, immediate memory, short-term memory, delayed memory, spatial working memory, and selective, alternative, and divided attention. Results In multivariate logistic regression analyses adjusted for grade and gender, scores of none of the cognitive tests were correlated with the prevalence of decrease in intrinsic academic motivation in elementary school students. However, low digit span forward test score and score for comprehension of the story in the kana pick-out test were positively correlated with the prevalence of decrease in intrinsic academic motivation in junior high school students. Conclusions The present findings suggest that decrease in capacity for verbal memory is associated with the prevalence of decrease in intrinsic academic motivation among junior high school students.

Relationship between cognitive function and prevalence of decrease in intrinsic academic motivation in adolescents.

Science.gov (United States)

Mizuno, Kei; Tanaka, Masaaki; Fukuda, Sanae; Imai-Matsumura, Kyoko; Watanabe, Yasuyoshi

2011-01-14

Decrease in intrinsic motivation is a common complaint among elementary and junior high school students, and is related to poor academic performance. Since grade-dependent development of cognitive functions also influences academic performance by these students, we examined whether cognitive functions are related to the prevalence of decrease in intrinsic academic motivation. The study group consisted of 134 elementary school students from 4th to 6th grades and 133 junior high school students from 7th to 9th grades. Participants completed a questionnaire on intrinsic academic motivation. They also performed paper-and-pencil and computerized cognitive tests to measure abilities in motor processing, spatial construction, semantic fluency, immediate memory, short-term memory, delayed memory, spatial working memory, and selective, alternative, and divided attention. In multivariate logistic regression analyses adjusted for grade and gender, scores of none of the cognitive tests were correlated with the prevalence of decrease in intrinsic academic motivation in elementary school students. However, low digit span forward test score and score for comprehension of the story in the kana pick-out test were positively correlated with the prevalence of decrease in intrinsic academic motivation in junior high school students. The present findings suggest that decrease in capacity for verbal memory is associated with the prevalence of decrease in intrinsic academic motivation among junior high school students.

Decreased ADAMTS 13 Activity is Associated With Disease Severity and Outcome in Pediatric Severe Sepsis

Science.gov (United States)

Lin, Jainn-Jim; Chan, Oi-Wa; Hsiao, Hsiang-Ju; Wang, Yu; Hsia, Shao-Hsuan; Chiu, Cheng-Hsun

2016-01-01

Abstract Decreased ADAMTS 13 activity has been reported in severe sepsis and in sepsis-induced disseminated intravascular coagulation. This study aimed to investigate the role of ADAMTS 13 in different pediatric sepsis syndromes and evaluate its relationship with disease severity and outcome. We prospectively collected cases of sepsis treated in a pediatric intensive care unit, between July 2012 and June 2014 in Chang Gung Children's Hospital in Taoyuan, Taiwan. Clinical characteristics and ADAMTS-13 activity were analyzed. All sepsis syndromes had decreased ADAMTS 13 activity on days 1 and 3 of admission compared to healthy controls. Patients with septic shock had significantly decreased ADAMTS 13 activity on days 1 and 3 compared to those with sepsis and severe sepsis. There was a significant negative correlation between ADAMTS 13 activity on day 1 and day 1 PRISM-II, PELOD, P-MOD, and DIC scores. Patients with mortality had significantly decreased ADAMTS 13 activity on day 1 than survivors, but not on day 3. Different pediatric sepsis syndromes have varying degrees of decreased ADAMTS 13 activity. ADAMTS 13 activity is strongly negatively correlated with disease severity of pediatric sepsis syndrome, whereas decreased ADAMTS 13 activity on day 1 is associated with increased risk of mortality. PMID:27100422

Decreased cerebral blood flow in renal transplant recipients

International Nuclear Information System (INIS)

Kamano, Chisako; Komaba, Yuichi; Sakayori, Osamu; Iino, Yasuhiko; Katayama, Yasuo

2002-01-01

We performed single-photon emission computed tomography (SPECT) to investigate the influence of renal transplantation on cerebral blood flow (CBF). Fifteen renal transplant recipients and twelve normal subjects underwent cerebral SPECT with N-isopropyl-p-[ 123 I] iodoamphetamine ( 123 I-IMP). All transplant recipients received prednisolone and cyclosporine (CyA). Regional CBF (rCBF) was measured by defining regions of interest in the cerebral cortex, deep white matter, striatum, thalamus, and cerebellum. In transplant recipients, correlations to the mean overall cortical CBF were assessed using the interval from transplantation to measurement of SPECT, as well as the serum creatinine concentration. Moreover, to investigate the influence of CyA on CBF, the correlation between mean overall cortical CBF and CyA trough concentrations was assessed. In all regions, CBF in renal transplant recipients was significantly lower than in normal subjects. No significant correlation was seen between serum creatinine, interval from transplantation, or CyA trough concentrations and mean overall cortical CBF. Renal transplant recipients demonstrated a decrease in CBF, that can have an associated secondary pathology. Therefore, renal transplant recipients may benefit from post-operative MRI or CT. (author)

BFKL jets: search for Higgs boson and graviton at the LHC

International Nuclear Information System (INIS)

Kim, V.T.; Evstyukhin, S.V.; Gavrilov, V.B.; Krokhotin, A.A.; Murzin, V.A.; Oreshkin, V.A.; Pivovarov, G.B.; Safronov, G.B.

2010-01-01

Monte Carlo event simulation with BFKL evolution is discussed. We report current status of a Monte Carlo event generator ULYSSES with BFKL evolution implemented. The ULYSSES, based on Pythia Monte Carlo generator, would help to reveal BFKL effects at LHC energies. In particular, such an observable as dijet K-factor can serve as a source of BFKL dynamics at the LHC, and it would also help to search for new physics.

Astrocytosis measured by 11C-deprenyl PET correlates with decrease in gray matter density in the parahippocampus of prodromal Alzheimer's patients

International Nuclear Information System (INIS)

Choo, IL Han; Carter, Stephen F.; Schoell, Michael L.; Nordberg, Agneta

2014-01-01

The Alzheimer's disease (AD) pathology is characterized by fibrillar amyloid deposits and neurofibrillary tangles, as well as the activation of astrocytosis, microglia activation, atrophy, dysfunctional synapse, and cognitive impairments. The aim of this study was to test the hypothesis that astrocytosis is correlated with reduced gray matter density in prodromal AD. Twenty patients with AD or mild cognitive impairment (MCI) underwent multi-tracer positron emission tomography (PET) studies with 11 C-Pittsburgh compound B ( 11 C-PIB), 18 F-Fluorodeoxyglucose ( 18 F-FDG), and 11 C-deuterium-L-deprenyl ( 11 C-DED) PET imaging, as well as magnetic resonance imaging (MRI) scanning, cerebrospinal fluid (CSF) biomarker analysis, and neuropsychological assessments. The parahippocampus was selected as a region of interest, and each value was calculated for four different imaging modalities. Correlation analysis was applied between DED slope values and gray matter (GM) densities by MRI. To further explore possible relationships, correlation analyses were performed between the different variables, including the CSF biomarker. A significant negative correlation was obtained between DED slope values and GM density in the parahippocampus in PIB-positive (PIB + ve) MCI patients (p = 0.025) (prodromal AD). Furthermore, in exploratory analyses, a positive correlation was observed between PIB-PET retention and DED binding in AD patients (p = 0.014), and a negative correlation was observed between PIB retention and CSF Aβ42 levels in MCI patients (p = 0.021), while the GM density and CSF total tau levels were negatively correlated in both PIB + ve MCI (p = 0.002) and MCI patients (p = 0.001). No significant correlation was observed with FDG-PET and with any of the other PET, MRI, or CSF biomarkers. High astrocytosis levels in the parahippocampus of PIB + ve MCI (prodromal AD) patients suggest an early preclinical influence on cellular tissue loss. The lack of correlation between

Recurrent variations of anomalous oxygen in association with a corotating interaction region

Directory of Open Access Journals (Sweden)

M. K. Reuss

Full Text Available The fluxes of anomalous oxygen (E ranging from 3.5-6.8 MeV/amu, as measured by the EPAC instrument on ULYSSES, show a recurrent variation with the solar rotation period, which is anticorrelated with the fluxes of particles accelerated at the shocks of a corotating interaction region (CIR, and correlated with the fluxes of galactic cosmic rays known to be modulated by the CIR. The amplitude of this variation is much higher than expected for galactic cosmic rays of the same rigidity.

Localization in a one-dimensional spatially correlated random potential

International Nuclear Information System (INIS)

Kasner, M.; Weller, W.

1986-01-01

The motion of an electron in a random one-dimensional spatially correlated potential is investigated. The spatial correlation is generated by a Markov chain. It is shown that the influence of the spatial correlation can be described by means of oscillating vertices usually neglected in the Berezinskii diagram technique. Correlation mainly leads to an increase of the localization length in comparison with an uncorrelated potential. However, there is a region of the parameter, where the localization decreases. (author)

Ion-neutral gas reactions in a collision/reaction cell in inductively coupled plasma mass spectrometry: Correlation of ion signal decrease to kinetic rate constants

Energy Technology Data Exchange (ETDEWEB)

Gray, Patrick J. [Trace Element Research Laboratory, School of Earth Sciences, The Ohio State University, 125 S. Oval Mall, Columbus, OH 43210 (United States); Department of Chemistry, The Ohio State University, 120 18th Avenue, Columbus, OH 43210 (United States); Olesik, John W., E-mail: olesik.2@osu.edu [Trace Element Research Laboratory, School of Earth Sciences, The Ohio State University, 125 S. Oval Mall, Columbus, OH 43210 (United States)

2015-03-01

Reaction gas flow rate dependent Ar{sub 2}{sup +} and Ar{sup +} signals are correlated to fundamental kinetic rate coefficients. A simple calculation, assuming that gas exits the reaction cell due only to effusion, is described to estimate the gas pressure in the reaction cell. The value of the product of the kinetic rate constant and the ion residence time in the reaction cell can be determined from experimental measurement of the decrease in an ion signal as a function of reaction gas flow rate. New kinetic rate constants are determined for the reaction of CH{sub 3}F with Ar{sup +} and Ar{sub 2}{sup +}. - Highlights: • How to determine pressure and the product of the kinetic rate constant times the ion residence time in reaction cell • Relate measured ICP-DRC-MS signals versus gas flow rate to kinetic rate constants measured previously using SIFT-MS • Describe how to determine previously unmeasured kinetic rate constants using ICP-DRC-MS.

Pathologic correlation to internal echogenicity of atypical breast fibroadenoma

International Nuclear Information System (INIS)

Cho, Nariya; Oh, Ki Keun; Kwon, Ryang; Han, Jae Ho; Jung, Woo Hee; Lee, Hy De

1998-01-01

To understand the cause of a typical sonographic findings by analyzing their pathologic correlation to internal echogenicity of breast fibroadenoma. Materials and Methods : Between January 1995 and April 1997, the presence of 91 fibroadenomas in 81 patients was histopathologically proven. These mass lesions were sonographically interpreted and their descriptive criteria-internal echo content (both strength and homogeneity),the presence of septum, bilateral shadowing, and posterior echo pattern-were tabulated. A pathologist reviewed each case and independently recorded the following data : cell type, the presence of septum, duct dilatation,calcification, fibrosis, hyalinization, and vascularity. We analyzed the correlation of sonographic with pathologic findings. Results : There was significant correlation between increased vascularity and increased internal echo strength and between increased fibrosis and decreased internal echo strength. There was no significant correlation between internal echo homogeneity or posterior shadowing and vascularity or stromal fibrosis, nor between hyalinization or cell type and internal echo strength, homogeneity or posterior shadowing.There was correlation between absent or thin capsule and the absence of bilateral shadowing. Conclusion :Increased vascularity or decreased stromal fibrosis might be the cause of atypical fibroadenoma

Pathologic correlation to internal echogenicity of atypical breast fibroadenoma

Energy Technology Data Exchange (ETDEWEB)

Cho, Nariya; Oh, Ki Keun; Kwon, Ryang; Han, Jae Ho; Jung, Woo Hee; Lee, Hy De [Yonsei Univ. College of Medicine, Seoul (Korea, Republic of)

1998-07-01

To understand the cause of a typical sonographic findings by analyzing their pathologic correlation to internal echogenicity of breast fibroadenoma. Materials and Methods : Between January 1995 and April 1997, the presence of 91 fibroadenomas in 81 patients was histopathologically proven. These mass lesions were sonographically interpreted and their descriptive criteria-internal echo content (both strength and homogeneity),the presence of septum, bilateral shadowing, and posterior echo pattern-were tabulated. A pathologist reviewed each case and independently recorded the following data : cell type, the presence of septum, duct dilatation,calcification, fibrosis, hyalinization, and vascularity. We analyzed the correlation of sonographic with pathologic findings. Results : There was significant correlation between increased vascularity and increased internal echo strength and between increased fibrosis and decreased internal echo strength. There was no significant correlation between internal echo homogeneity or posterior shadowing and vascularity or stromal fibrosis, nor between hyalinization or cell type and internal echo strength, homogeneity or posterior shadowing.There was correlation between absent or thin capsule and the absence of bilateral shadowing. Conclusion :Increased vascularity or decreased stromal fibrosis might be the cause of atypical fibroadenoma.

Decreased expression of LATS1 is correlated with the progression and prognosis of glioma

Directory of Open Access Journals (Sweden)

Ji Tianhai

2012-08-01

Full Text Available Abstract Background LATS1 is a tumor suppressor genes implicated in the pathogenesis of certain types of tumors, but its role is not known in human glioma. Methods Using real-time PCR and immunohistochemistry, we detected the mRNA and protein expression of LATS1 in glioma. The effect of LATS1 on cell growth and invasion were investigated. Results We found that mRNA and protein of LATS1 expression is significantly downregulated in glioma compared with normal control brain tissues. Furthermore, reduced LATS1 expression was markedly negatively correlated with WHO grade and KPS (p Conclusion These results indicate that LATS1 is an important candidate tumor suppressor and its downregulated expression may contribute to glioma progression.

Decreased apparent diffusion coefficient in the pituitary and correlation with hypopituitarism in patients with traumatic brain injury.

Science.gov (United States)

Zheng, Ping; He, Bin; Guo, Yijun; Zeng, Jingsong; Tong, Wusong

2015-07-01

The relationship between microstructural abnormality in patients with traumatic brain injury (TBI) and hormone-secreting status remains unknown. In this study, the authors aimed to identify the role of the apparent diffusion coefficient (ADC) using a diffusion-weighted imaging (DWI) technique and to evaluate the association of such changes with hypopituitarism in patients with TBI. Diffusion-weighted images were obtained in 164 consecutive patients with TBI within 2 weeks after injury to generate the pituitary ADC as a measure of microstructural change. Patients with TBI were further grouped into those with and those without hypopituitarism based on the secretion status of pituitary hormones at 6 months postinjury. Thirty healthy individuals were enrolled in the study and underwent MRI examinations for comparison. Mean ADC values were compared between this control group, the patients with TBI and hypopituitarism, and the patients with TBI without hypopituitarism; correlational studies were also performed. Neurological outcome was assessed with the Glasgow Outcome Scale (GOS) for all TBI patients 6 months postinjury. In the TBI group, 84 patients had hypopituitarism and 80 had normal pituitary function. The pituitary ADC in TBI patients was significantly less than that in controls (1.83 ± 0.16 vs 4.13 ± 0.33, p correlated with neurological outcome at 6 months following TBI (r = 0.602, p correlated with hormone-secreting status in TBI patients. The authors suggest that pituitary ADC may be a useful biomarker to predict pituitary function in patients with TBI.

Status report on performance of radioisotope thermoelectric generators using silicon germanium thermoelectric elements

International Nuclear Information System (INIS)

Bennett, G.L.; Campbell, R.W.; Putnam, L.R.; Hemler, R.J.

1994-01-01

Three general-purpose heat source radioisotope thermoelectric generators (GPHS-RTGs) are currently in use in space: two on board the Galileo spacecraft on its way to Jupiter and one on the Ulysses spacecraft exploring the polar regions of the Sun. The GPHS-RTG was designed to provide at least 285 W(e) at the beginning of mission (BOM) within a mass constraint of 56 kg and an overall size envelope of 42.2 cm in diameter and 114 cm in length. The Galileo spacecraft, which as already sent back exciting scientific information on Venus, Earth, and the asteroids Gaspra and Ida, carries two GPHS-RTGs which operate at 30 V. The Ulysses spacecraft, which has already successfully swung past Jupiter on its way to the southern polar regions of the Sun, carries one GPHS-RTG which operates at 28 V. The analyses presented in the paper show that both Galileo and Ulysses will have sufficient power for the baseline missions and analyses are under way to determine the power available for an extended Ulysses mission out to the year 2002. Ten other silicon-germanium-based RTGs on the LES 8/9 and Voyager 1/2 spacecraft have completed their prime missions and are now successfully performing extended missions

Uncertain Dynamics, Correlation Effects, and Robust Investment Decisions

DEFF Research Database (Denmark)

Flor, Christian Riis; Hesel, Søren

2015-01-01

We analyze a firm's investment problem when the dynamics of project value and investment cost are uncertain. We provide an explicit solution using a robust method for an ambiguity averse firm taking this into account. Ambiguity aversion regarding a common risk factor impacts differently than...... ambiguity aversion regarding investment cost residual risk. Correlation between project value and investment cost matters; ambiguity aversion regarding common risk can decrease the investment probability only if correlation is positive. Ambiguity aversion regarding residual risk always increases...... the investment probability. When only project value is risky, volatility can monotonically decrease the investment threshold; this does not hold with the multiple prior method....

Decreased Expression of DREAM Promotes the Degeneration of Retinal Neurons

Science.gov (United States)

Chintala, Shravan; Cheng, Mei; Zhang, Xiao

2015-01-01

The intrinsic mechanisms that promote the degeneration of retinal ganglion cells (RGCs) following the activation of N-Methyl-D-aspartic acid-type glutamate receptors (NMDARs) are unclear. In this study, we have investigated the role of downstream regulatory element antagonist modulator (DREAM) in NMDA-mediated degeneration of the retina. NMDA, phosphate-buffered saline (PBS), and MK801 were injected into the vitreous humor of C57BL/6 mice. At 12, 24, and 48 hours after injection, expression of DREAM in the retina was determined by immunohistochemistry, western blot analysis, and electrophoretic mobility-shift assay (EMSA). Apoptotic death of cells in the retina was determined by terminal deoxynucleotidyl transferace dUTP nick end labeling (TUNEL) assays. Degeneration of RGCs in cross sections and in whole mount retinas was determined by using antibodies against Tuj1 and Brn3a respectively. Degeneration of amacrine cells and bipolar cells was determined by using antibodies against calretinin and protein kinase C (PKC)-alpha respectively. DREAM was expressed constitutively in RGCs, amacrine cells, bipolar cells, as well as in the inner plexiform layer (IPL). NMDA promoted a progressive decrease in DREAM levels in all three cell types over time, and at 48 h after NMDA-treatment very low DREAM levels were evident in the IPL only. DREAM expression in retinal nuclear proteins was decreased progressively after NMDA-treatment, and correlated with its decreased binding to the c-fos-DRE oligonucleotides. A decrease in DREAM expression correlated significantly with apoptotic death of RGCs, amacrine cells and bipolar cells. Treatment of eyes with NMDA antagonist MK801, restored DREAM expression to almost normal levels in the retina, and significantly decreased NMDA-mediated apoptotic death of RGCs, amacrine cells, and bipolar cells. Results presented in this study show for the first time that down-regulation of DREAM promotes the degeneration of RGCs, amacrine cells, and

Electron correlation energy in confined two-electron systems

Energy Technology Data Exchange (ETDEWEB)

Wilson, C.L. [Chemistry Program, Centre College, 600 West Walnut Street, Danville, KY 40422 (United States); Montgomery, H.E., E-mail: ed.montgomery@centre.ed [Chemistry Program, Centre College, 600 West Walnut Street, Danville, KY 40422 (United States); Sen, K.D. [School of Chemistry, University of Hyderabad, Hyderabad 500 046 (India); Thompson, D.C. [Chemistry Systems and High Performance Computing, Boehringer Ingelheim Pharamaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT 06877 (United States)

2010-09-27

Radial, angular and total correlation energies are calculated for four two-electron systems with atomic numbers Z=0-3 confined within an impenetrable sphere of radius R. We report accurate results for the non-relativistic, restricted Hartree-Fock and radial limit energies over a range of confinement radii from 0.05-10a{sub 0}. At small R, the correlation energies approach limiting values that are independent of Z while at intermediate R, systems with Z{>=}1 exhibit a characteristic maximum in the correlation energy resulting from an increase in the angular correlation energy which is offset by a decrease in the radial correlation energy.

Age-Related Decrease in Stress Responsiveness and Proactive Coping in Male Mice.

Science.gov (United States)

Oh, Hee-Jin; Song, Minah; Kim, Young Ki; Bae, Jae Ryong; Cha, Seung-Yun; Bae, Ji Young; Kim, Yeongmin; You, Minsu; Lee, Younpyo; Shim, Jieun; Maeng, Sungho

2018-01-01

Coping is a strategic approach to dealing with stressful situations. Those who use proactive coping strategies tend to accept changes and act before changes are expected. In contrast, those who use reactive coping are less flexible and more likely to act in response to changes. However, little research has assessed how coping style changes with age. This study investigated age-related changes in coping strategies and stress responsiveness and the influence of age on the processing of conditioned fear memory in 2-, 12- and 23-month-old male mice. Coping strategy was measured by comparing the escape latency in an active avoidance test and by comparing responses to a shock prod. The results showed that proactivity in coping response gradually decreased with age. Stress responsiveness, measured by stress-induced concentration of corticosterone, was also highest in 2-month-old mice and decreased with age. Consolidation of fear memory was highest in 12-month-old mice and was negatively correlated with the degree of stress responsiveness and proactivity in coping. Fear extinction did not differ among age groups and was not correlated with stress responsiveness or the proactivity of coping. However, the maintenance of extinct fear memory, which was best in 2-month-old mice and worst in 12-month-old mice, was negatively correlated with stress responsiveness but not with coping style. Age-dependent changes in the expression of glucocorticoid receptor (GR) and its regulatory co-chaperones, which are accepted mechanisms for stress hormone stimulation, were measured in the hippocampus. The expression of GR was increased at 12 months compared to other age groups. There were no differences in Hsp70 and BAG1 expression by age. These results can be summarized as follows: (1) stress responsiveness and proactivity in coping decreased with age class; (2) consolidation of fear memory was negatively correlated with both stress responsiveness and proactivity; however, maintenance of

Correlation Coefficients: Appropriate Use and Interpretation.

Science.gov (United States)

Schober, Patrick; Boer, Christa; Schwarte, Lothar A

2018-05-01

Correlation in the broadest sense is a measure of an association between variables. In correlated data, the change in the magnitude of 1 variable is associated with a change in the magnitude of another variable, either in the same (positive correlation) or in the opposite (negative correlation) direction. Most often, the term correlation is used in the context of a linear relationship between 2 continuous variables and expressed as Pearson product-moment correlation. The Pearson correlation coefficient is typically used for jointly normally distributed data (data that follow a bivariate normal distribution). For nonnormally distributed continuous data, for ordinal data, or for data with relevant outliers, a Spearman rank correlation can be used as a measure of a monotonic association. Both correlation coefficients are scaled such that they range from -1 to +1, where 0 indicates that there is no linear or monotonic association, and the relationship gets stronger and ultimately approaches a straight line (Pearson correlation) or a constantly increasing or decreasing curve (Spearman correlation) as the coefficient approaches an absolute value of 1. Hypothesis tests and confidence intervals can be used to address the statistical significance of the results and to estimate the strength of the relationship in the population from which the data were sampled. The aim of this tutorial is to guide researchers and clinicians in the appropriate use and interpretation of correlation coefficients.

Response of epiphytic lichen communities to decreasing ammonia air concentrations in a moderately polluted area of The Netherlands

International Nuclear Information System (INIS)

Sparrius, Laurens B.

2007-01-01

Decreasing local ammonia air concentrations in a moderately polluted area in The Netherlands were accompanied by a rapid increase in nitrogen-sensitive species (acidophytes) and a decline of nitrogen-tolerant macrolichens (nitrophytes). This paper presents data on the relationship between nitrophyte abundance and species abundance for three ecological groups of epiphytic lichens: nitrophytes (positively correlated with ammonia), acidophytes (negatively correlated) and neutrophytes (which have an optimum at medium concentrations) and suggests ammonia dependent optimum curves for these groups. In this study neutrophytes were found to die-off massively at sites with a decrease of the ammonia air concentration over the period 1996-2003. - Lichens can be used to detect both increasing and decreasing ammonia air concentrations

Clinical correlates of decreased anteroposterior metabolic gradients in positron emission tomography (PET) of schizophrenic patients

International Nuclear Information System (INIS)

DeLisi, L.E.; Buchsbaum, M.S.; Holcomb, H.H.

1985-01-01

The finding in schizophrenic patients of a reversal of the normal frontal to posterior pattern of brain metabolic activity with positron emission tomography (PET) is of interest, but its relevance to psychopathology is unknown. Using PET, the authors studied 21 patients with chronic schizophrenia and 21 age- and sex-matched control subjects. Although eight of the 21 patients and only one of the control subjects showed a relatively lower anteroposterior metabolic gradient, no clinical correlates of this finding were noted. In addition, cerebral atrophy, as determined by CAT scan, was not associated with this aberrant metabolic pattern

Ulysses of Embra

Directory of Open Access Journals (Sweden)

Johnston Paul

2017-06-01

Full Text Available A critical day in the life of Leonard Rose, an Edinburgh (Embra criminal with undertones of Homer’s Odysseus and James Joyce’s Leopold Bloom. He thinks of his son, Stevie, whom he has not seen for fifteen years. After his morning ablutions he attends the cremation service of a notable lawyer, who had ties to local crime kingpin, Big Sam. Leonard is shaken by visions of the people he murdered for Big Sam. Stevie is waiting outside, accompanied by two detectives. Leonard is told that his ex-wife, Penny, is setting up Glasgow gang boss Boy ‘The Boiler’ Boyle. Leonard takes the police to his bar, the End of the World, aware that Big Sam’s number two, Nessie, is following. After knocking the policemen out and overpowering Nessie and his men, Leonard and Stevie go to Big Sam’s palatial home. When he understands that Penny intended to betray Big Sam as well, Leonard deserts his son and goes home, free of emotional and professional ties. He decides to leave Edinburgh and go inland, where no one knows him. But before that he will knock on his female neighbour’s door, hoping she will give his attentions a positive reception.

Cinderella Meets Ulysses.

Science.gov (United States)

Mello, Robin

2001-01-01

Presents a study of boys' and girls' conversations about traditional folktales. Focuses on storytelling as a teaching method and explores how students learn from folktales, myths, and legends. Investigates how characters and gender roles in folktales and other traditional stories act as educational and developmental models, especially among…

Audit calculation and comments on a new CHF correlation

Energy Technology Data Exchange (ETDEWEB)

Auh, Geun Sun [Korea Institute of Nuclear Safety, Daejon (Korea, Republic of); Hwang, Dae Hyun [Korea Atomic Energy Research Institute, Daejon (Korea, Republic of)

2008-10-15

An audit calculation was conducted for a local parameter CHF correlation which was intended for the thermal hydraulic design calculations of a new type of fuel assembly, named 17x17 type ACE7. The proposed empirical correlation calculates the CHF as a function of local conditions in a rod bundle which were evaluated by the subchannel analysis code THINC. The CHF data base for this correlation consisted of 4 test bundles with a total of 295 data points. Independent audit calculation was performed in order to substantiate the analyses results for the proposed correlation. Total 295 calculations were performed with a subchannel code MATRA and the results were compared with the results of THINC calculations. A new feature of the proposed correlation is a correction factor for axially non uniform power shapes. The proposed correction factor model contends a decrease of upstream memory effect with a decrease of the grid spacing. The physical background as well as the CHF data base supporting the magnitude of the correction factor was closely investigated. From the results of the investigation, the applicability limitations such as 3.5% penalty factor on the DNBR and 17x17 type ACE7 fuel assembly application only were self imposed on the proposed correlation.

Severe geomagnetic storms and Forbush decreases: interplanetary relationships reexamined

Directory of Open Access Journals (Sweden)

R. P. Kane

2010-02-01

Full Text Available Severe storms (Dst and Forbush decreases (FD during cycle 23 showed that maximum negative Dst magnitudes usually occurred almost simultaneously with the maximum negative values of the Bz component of interplanetary magnetic field B, but the maximum magnitudes of negative Dst and Bz were poorly correlated (+0.28. A parameter Bz(CP was calculated (cumulative partial Bz as sum of the hourly negative values of Bz from the time of start to the maximum negative value. The correlation of negative Dst maximum with Bz(CP was higher (+0.59 as compared to that of Dst with Bz alone (+0.28. When the product of Bz with the solar wind speed V (at the hour of negative Bz maximum was considered, the correlation of negative Dst maximum with VBz was +0.59 and with VBz(CP, 0.71. Thus, including V improved the correlations. However, ground-based Dst values have a considerable contribution from magnetopause currents (several tens of nT, even exceeding 100 nT in very severe storms. When their contribution is subtracted from Dst(nT, the residue Dst* representing true ring current effect is much better correlated with Bz and Bz(CP, but not with VBz or VBz(CP, indicating that these are unimportant parameters and the effect of V is seen only through the solar wind ram pressure causing magnetopause currents. Maximum negative Dst (or Dst* did not occur at the same hour as maximum FD. The time evolutions of Dst and FD were very different. The correlations were almost zero. Basically, negative Dst (or Dst* and FDs are uncorrelated, indicating altogether different mechanism.

Le monde méditerranéen et la transposition caraïbe du mythe d'Ulysse The Mediterranean World and the Caribbean Transposition of the Myth of Ulysses El mundo mediterráneo y la transposición caribeña del mito de Ulises

Directory of Open Access Journals (Sweden)

Arnaud Dornon

1997-05-01

Full Text Available Cet article a pour vocation de faire apparaître la relation privilégiée qui existe entre Walcott, poète de Sainte Lucie, anglophone et créolophone, Prix Nobel de Littérature en 1992, et la culture du berceau méditerranéen. Rares sont en effet les poètes antillais d'origine africaine qui n'ont ni épousé les théories de Césaire et de Senghor sur la Négritude, ni revendiqué à haute voix comme Glissant leur Africanité ou insisté sur leur origine d'un regard tourné vers le continent noir. L'œuvre poétique de Walcott est un miroir de son évolution dont l'aboutissement correspond à l'affirmation d'une personnalité, d'un individu. Il balaie toute appartenance à une race, à une religion et réussit à faire apparaître une entité caraïbe sans revendication autre qu'une reconnaissance culturelle non « authentique » dans le sens traditionnel du terme mais originale car acceptant une triple paternité, un savant mélange - métissage dirait-on - d'Afrique, d'Europe et d'Amérique. La société des caraïbes a évolué, nous dit-il, la créolisation en est son image de marque. L'imaginaire européen a donc cours aux Antilles, imaginaire dans lequel s'insère bien évidemment le mythe d'Ulysse. Walcott l'exploite, l'illustre et l'adapte à son paysage régional, puis le débarrasse de son enveloppe européenne, de son contenu religieux, pour redonner à ce mythe la valeur universelle qui est sienne.The purpose of this paper is to reveal the privileged relationship between the culture of the Mediterranean birthplace and Walcott, a poet from Saint Lucia who speaks both Creole and English, and won the 1992 Nobel Prize for literature. Indeed, one can scarcely meet a Caribbean poet of African origin who does not adopt Césaire's and Senghor's theories on négritude, nor loudly claim, like Glissant, his African roots, insisting on his origins by turning his eyes towards the black continent. Walcott's poetical works mirror his

Neural correlates of skill acquisition: decreased cortical activity during a serial interception sequence learning task.

Science.gov (United States)

Gobel, Eric W; Parrish, Todd B; Reber, Paul J

2011-10-15

Learning of complex motor skills requires learning of component movements as well as the sequential structure of their order and timing. Using a Serial Interception Sequence Learning (SISL) task, participants learned a sequence of precisely timed interception responses through training with a repeating sequence. Following initial implicit learning of the repeating sequence, functional MRI data were collected during performance of that known sequence and compared with activity evoked during novel sequences of actions, novel timing patterns, or both. Reduced activity was observed during the practiced sequence in a distributed bilateral network including extrastriate occipital, parietal, and premotor cortical regions. These reductions in evoked activity likely reflect improved efficiency in visuospatial processing, spatio-motor integration, motor planning, and motor execution for the trained sequence, which is likely supported by nondeclarative skill learning. In addition, the practiced sequence evoked increased activity in the left ventral striatum and medial prefrontal cortex, while the posterior cingulate was more active during periods of better performance. Many prior studies of perceptual-motor skill learning have found increased activity in motor areas of the frontal cortex (e.g., motor and premotor cortex, SMA) and striatal areas (e.g., the putamen). The change in activity observed here (i.e., decreased activity across a cortical network) may reflect skill learning that is predominantly expressed through more accurate performance rather than decreased reaction time. Copyright © 2011 Elsevier Inc. All rights reserved.

Decreased Hepatocyte Growth Factor (HGF) and Gamma Aminobutyric Acid (GABA) in Individuals with Obsessive-Compulsive Disorder (OCD).

Science.gov (United States)

Russo, Anthony J; Pietsch, Stefanie C

2013-01-01

There is support for the role of gamma aminobutyric acid (GABA) in the etiology of mood disorders. Recent research has shown that hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility. This study was designed to determine and correlate plasma levels of HGF and GABA as well as symptom severity in individuals with obsessive-compulsive disorder (OCD). Plasma from 15 individuals with OCD (9 males, 6 females;, mean age 38.7 years) and 17 neurotypical controls (10 males, 7 females; mean age 35.2 years) was assessed for HGF, GABA, urokinase plasminogen activator (uPA), and urokinase plasminogen activator receptor (uPAR) concentration using enzyme-linked immunosorbest assays ELISAs. Symptom severity was assessed in these OCD individuals and compared with HGF and GABA concentrations. In this preliminary study, individuals with OCD had significantly decreased HGF levels, decreased plasma levels of GABA and decreased uPA. We found that both uPA and uPAR levels correlate with HGF. Both low uPA and low uPAR levels correlate with high symptom severity in individuals with OCD. Low GABA levels in OCD individuals also correlate with high symptom severity. These results demonstrate a preliminary association between HGF, GABA, uPA levels, and OCD and suggest that plasma GABA and uPA levels are related to symptom severity in individuals with OCD.

Decreased sexual motivation and heightened anxiety in male Long-Evans rats are correlated with the memory for a traumatic event.

Science.gov (United States)

Hawley, Wayne R; Grissom, Elin M; Belkin, Mark N; James, Thomas F; Dohanich, Gary P

2013-05-01

Individuals suffering from posttraumatic stress disorder (PTSD) frequently report disturbances in sexual functioning in addition to alterations in their affective behaviors. Notably, maladaptive cognitions and dysfunctional behaviors are perpetuated by the emergence of the intrusive thoughts that characterize the disorder. In rats, reminders of a traumatic event designed to simulate intrusive thoughts are associated with impairments in affective, social, and sexual behaviors. The current study examined the relationship between the memory for a traumatic event and changes in sexual and affective behaviors in male Long-Evans rats (N = 36). The trauma featured a combination stressor consisting of simultaneous exposure to a footshock and the odor of soiled cat litter. Memory for the trauma was reactivated by re-exposures to the context of the trauma in the absence of stressors and confirmed by assessing the percentage of time spent freezing. Following the second and final reminder, traumatized males exhibited reduced sexual motivation and increased anxiety, signified by longer latencies to achieve their first mount on a post-stress test of sexual behavior, and longer latencies to begin feeding in a novel environment, respectively. Correlational analyses revealed that decreased sexual motivation and heightened anxiety were predicted by the memory for the trauma as indicated by the time spent freezing during the re-exposures. The findings from the current study have implications for understanding the relationship between stress and sexual functioning and indicate that the impairments in sexual behavior that often occur in individuals with PTSD may be impacted by their memory for the trauma.

ENERGETIC PARTICLE OBSERVATIONS AND PROPAGATION IN THE THREE-DIMENSIONAL HELIOSPHERE DURING THE 2006 DECEMBER EVENTS

International Nuclear Information System (INIS)

Malandraki, O. E.; Marsden, R. G.; Tranquille, C.; Lario, D.; Heber, B.; Mewaldt, R. A.; Cohen, C. M. S.; Lanzerotti, L. J.; Forsyth, R. J.; Elliott, H. A.; Vogiatzis, I. I.; Geranios, A.

2009-01-01

We report observations of solar energetic particles obtained by the HI-SCALE and COSPIN/LET instruments onboard Ulysses during the period of isolated but intense solar activity in 2006 December, in the declining phase of the solar activity cycle. We present measurements of particle intensities and also discuss observations of particle anisotropies and composition in selected energy ranges. Active Region 10930 produced a series of major solar flares with the strongest one (X9.0) recorded on December 5 after it rotated into view on the solar east limb. Located over the South Pole of the Sun, at >72 0 S heliographic latitude and 2.8 AU radial distance, Ulysses provided unique measurements for assessing the nature of particle propagation to high latitudes under near-minimum solar activity conditions, in a relatively undisturbed heliosphere. The observations seem to exclude the possibility that magnetic field lines originating at low latitudes reached Ulysses, suggesting either that the energetic particles observed as large solar energetic particle (SEP) events over the South Pole of the Sun in 2006 December were released when propagating coronal waves reached high-latitude field lines connected to Ulysses, or underwent perpendicular diffusion. We also discuss comparisons with energetic particle data acquired by the STEREO and Advanced Composition Explorer in the ecliptic plane near 1 AU during this period.

Short-arc orbit determination using coherent X-band ranging data

Science.gov (United States)

Thurman, S. W.; Mcelrath, T. P.; Pollmeier, V. M.

1992-01-01

The use of X-band frequencies in ground-spacecraft and spacecraft-ground telecommunication links for current and future robotic interplanetary missions makes it possible to perform ranging measurements of greater accuracy than previously obtained. It is shown that ranging data of sufficient accuracy, when acquired from multiple stations, can sense the geocentric angular position of a distant spacecraft. The application of high-accuracy S/X-band and X-band ranging to orbit determination with relatively short data arcs is investigated in planetary approach and encounter scenarios. Actual trajectory solutions for the Ulysses spacecraft constructed from S/X-band ranging and Doppler data are presented; error covariance calculations are used to predict the performance of X-band ranging and Doppler data. The Ulysses trajectory solutions indicate that the aim point for the spacecraft's February 1992 Jupiter encounter was predicted to a geocentric accuracy of 0.20 to 0.23/microrad. Explicit modeling of range bias parameters for each station pass is shown to largely remove systematic ground system calibration errors and transmission media effects from the Ulysses range measurements, which would otherwise corrupt the angle finding capabilities of the data. The Ulysses solutions were found to be reasonably consistent with the theoretical results, which suggest that angular accuracies of 0.08 to 0.1/microrad are achievable with X-band ranging.

Inner heliosphere spatial gradients of GCR protons and alpha particles in the low GeV range

Science.gov (United States)

Gieseler, J.; Boezio, M.; Casolino, M.; De Simone, N.; Di Felice, V.; Heber, B.; Martucci, M.; Picozza, P.

2013-12-01

The spacecraft Ulysses was launched in October 1990 in the maximum phase of solar cycle 22, reached its final, highly inclined (80.2°) Keplerian orbit around the Sun in February 1992, and was finally switched off in June 2009. The Kiel Electron Telescope (KET) aboard Ulysses measures electrons from 3 MeV to a few GeV and protons and helium in the energy range from 6 MeV/nucleon to above 2 GeV/nucleon. In order to investigate the radial and latitudinal gradients of galactic cosmic rays (GCR), it is essential to know their intensity variations for a stationary observer in the heliosphere because the Ulysses measurements reflect not only the spatial but also the temporal variation of the energetic particle intensities. This was accomplished in the past with the Interplanetary Monitoring Platform-J (IMP 8) until it was lost in 2006. Fortunately, the satellite-borne experiment PAMELA (Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics) was launched in June 2006 and can be used as a reliable 1 AU baseline for measurements of the KET aboard Ulysses. With these tools at hand, we have the opportunity to determine the spatial gradients of GCR protons and alpha particles at about 0.1 to 1 GeV/n in the inner heliosphere during the extended minimum of solar cycle 23. We then compare these A0 cycle.

Properties of solar proton events at large heliocentric distances near ecliptic

International Nuclear Information System (INIS)

Khiber, B.; Struminskij, A.B.

2005-01-01

The absolute intensities, fluences and propagation times of the solar protons with the energy of 38-125 MeV, obtained on the basis of the observation data of the Kilskij electron telescope (KET ULYSSES) onboard the ULYSSES cosmic apparatus and GOES proton detector, are compared. The observation data on the solar cosmic rays at the heliocentric distances above 5 a.e. are analyzed for the first time. Certain characteristics of the proton events under consideration and their possible parent flares are presented [ru

Expiratory CT in cigarette smokers: correlation between areas of decreased lung attenuation, pulmonary function tests and smoking history

Energy Technology Data Exchange (ETDEWEB)

Verschakelen, J.A.; Scheinbaum, K.; Bogaert, J.; Baert, A.L. [Department of Radiology, University Hospitals, Leuven (Belgium); Demedts, M.; Lacquet, L.L. [Department of Pneumology, University Hospitals, Leuven (Belgium)

1998-10-01

The aim of this study was to determine the correlation between cigarette-smoke-related bronchial disease and air trapping as assessed by expiratory high-resolution CT (HRCT) scans. Thirty healthy subjects (11 non-smokers, 7 ex-smokers for > 2 years, 12 current smokers; age range 35-55 years) with a smoking history between 0 and 28.5 pack-years underwent pulmonary function tests (PFT) and HRCT in inspiration and expiration in supine and prone position. The extent of air trapping was scored in ventral and dorsal aspects of the upper, middle and lower lung portions. In 24 subjects (7 non-smokers, 7 ex-smokers, 10 current smokers) areas of focal air trapping were found, and were present significantly more often in dependent lung portions (p < 0.05) compared with non-dependent portions. No significant differences were found between apical and basal lung zones. Scores of focal air trapping were not significantly different between smokers and ex-smokers, but were significantly lower (p < 0.05) in non-smokers and showed a significant (p < 0.0005) correlation with pack-years. The degree of air trapping was also associated with several lung function tests, especially RV, DLCO, FRC, FEV1 and FEV1/VC. Air trapping is seen in smokers with normal PFT and correlates with the severity of the smoking history, independently of current smoking status. (orig.) (orig.) With 4 figs., 4 tabs., 59 refs.

A deletion within glycoprotein L of Marek's disease virus (MDV) field isolates correlates with a decrease in bivalent MDV vaccine efficacy in contact-exposed chickens.

Science.gov (United States)

Tavlarides-Hontz, Phaedra; Kumar, Pankaj M; Amortegui, Juliana Rojas; Osterrieder, Nikolaus; Parcells, Mark S

2009-06-01

We examined the functional role of a naturally occurring deletion within the glycoprotein L (gL) gene of Marek's disease virus (MDV) field isolates. We previously showed that this mutation incrementally increased the virulence of an MDV in contact-exposed SPF leghorn chickens, when chickens shedding this virus were co-infected with herpesvirus of turkeys (HVT). In our present study, we examined this mutation using two stocks of the very virulent plus (vv+)MDV strain TK, one of which harbored this deletion (TK1a) while the other did not (TK2a). We report that TK1a replicating in vaccinated chickens overcame bivalent (HVT/SB1) vaccine protection in contact-exposed chickens. Treatment groups exposed to vaccinated chickens inoculated with a 1:1 mix of TK1a and TK2a showed decreased bivalent vaccine efficacy, and this decrease correlated with the prevalence of the gL deletion indicative of TK1a. These results were also found using quadruplicate treatment groups and bivalently vaccinated chickens obtained from a commercial hatchery. As this deletion was found in 25 out of 25 recent field isolates from Delaware, Maryland, North Carolina, Pennsylvania, and Virginia, we concluded that there is a strong selection for this mutation, which appears to have evolved in HVT or bivalently vaccinated chickens. This is the first report of a mutation in a vv+MDV field strain for which a putative biological phenotype has been discerned. Moreover, this mutation in gL has apparently been selected in MDV field isolates through Marek's disease vaccination.

Detailed L3 measurements of Bose-Einstein correlations and a region of anti-correlations in hadronic $Z^0$ decays at LEP

CERN Document Server

Csorgo, T.; Kittel, W.; Novak, T.

2010-01-01

L3 preliminary data of two-particle Bose-Einstein correlations are reported for hadronic Z^0 decays in e+e- annihilation at LEP. The invariant relative momentum Q is identified as the eigenvariable of the measured correlation function. Significant anti-correlations are observed in the Bose-Einstein correlation function in a broad region of 0.5 - 1.6 GeV with a minimum at Q close to 0.8 GeV. Absence of Bose-Einstein correlations is demonstrated in the region above Q >= 1.6 GeV. The effective source size is found to decrease with increasing value of the transverse mass of the pair, similarly to hadron-hadron and heavy ion reactions. These feautes and our data are described well by the non-thermal tau-model, which is based on strong space-time momentum-correlations.

Adapted all-numerical correlator for face recognition applications

Science.gov (United States)

Elbouz, M.; Bouzidi, F.; Alfalou, A.; Brosseau, C.; Leonard, I.; Benkelfat, B.-E.

2013-03-01

In this study, we suggest and validate an all-numerical implementation of a VanderLugt correlator which is optimized for face recognition applications. The main goal of this implementation is to take advantage of the benefits (detection, localization, and identification of a target object within a scene) of correlation methods and exploit the reconfigurability of numerical approaches. This technique requires a numerical implementation of the optical Fourier transform. We pay special attention to adapt the correlation filter to this numerical implementation. One main goal of this work is to reduce the size of the filter in order to decrease the memory space required for real time applications. To fulfil this requirement, we code the reference images with 8 bits and study the effect of this coding on the performances of several composite filters (phase-only filter, binary phase-only filter). The saturation effect has for effect to decrease the performances of the correlator for making a decision when filters contain up to nine references. Further, an optimization is proposed based for an optimized segmented composite filter. Based on this approach, we present tests with different faces demonstrating that the above mentioned saturation effect is significantly reduced while minimizing the size of the learning data base.

Resistance to oxidative stress induced by paraquat correlates well with both decreased and increased lifespan in Drosophila melanogaster

NARCIS (Netherlands)

Vermeulen, CJ; Van De Zande, L; Bijlsma, R

2005-01-01

There is increasing support for the notion that genetic variation for lifespan, both within and between species, is correlated with variation in the efficiency of the free radical scavenging system and the ability to withstand oxidative stress. In Drosophila, resistance to dietary paraquat, a free

The impact of electrostatic correlations on Dielectrophoresis of Non-conducting Particles

Science.gov (United States)

Alidoosti, Elaheh; Zhao, Hui

2017-11-01

The dipole moment of a charged, dielectric, spherical particle under the influence of a uniform alternating electric field is computed theoretically and numerically by solving the modified continuum Poisson-Nernst-Planck (PNP) equations accounting for ion-ion electrostatic correlations that is important at concentrated electrolytes (Phys. Rev. Lett. 106, 2011). The dependence on the frequency, zeta potential, electrostatic correlation lengths, and double layer thickness is thoroughly investigated. In the limit of thin double layers, we carry out asymptotic analysis to develop simple models which are in good agreement with the modified PNP model. Our results suggest that the electrostatic correlations have a complicated impact on the dipole moment. As the electrostatic correlations length increases, the dipole moment decreases, initially, reach a minimum, and then increases since the surface conduction first decreases and then increases due to the ion-ion correlations. The modified PNP model can improve the theoretical predictions particularly at low frequencies where the simple model can't qualitatively predict the dipole moment. This work was supported, in part, by NIH R15GM116039.

Image scale measurement with correlation filters in a volume holographic optical correlator

Science.gov (United States)

Zheng, Tianxiang; Cao, Liangcai; He, Qingsheng; Jin, Guofan

2013-08-01

A search engine containing various target images or different part of a large scene area is of great use for many applications, including object detection, biometric recognition, and image registration. The input image captured in realtime is compared with all the template images in the search engine. A volume holographic correlator is one type of these search engines. It performs thousands of comparisons among the images at a super high speed, with the correlation task accomplishing mainly in optics. However, the inputted target image always contains scale variation to the filtering template images. At the time, the correlation values cannot properly reflect the similarity of the images. It is essential to estimate and eliminate the scale variation of the inputted target image. There are three domains for performing the scale measurement, as spatial, spectral and time domains. Most methods dealing with the scale factor are based on the spatial or the spectral domains. In this paper, a method with the time domain is proposed to measure the scale factor of the input image. It is called a time-sequential scaled method. The method utilizes the relationship between the scale variation and the correlation value of two images. It sends a few artificially scaled input images to compare with the template images. The correlation value increases and decreases with the increasing of the scale factor at the intervals of 0.8~1 and 1~1.2, respectively. The original scale of the input image can be measured by estimating the largest correlation value through correlating the artificially scaled input image with the template images. The measurement range for the scale can be 0.8~4.8. Scale factor beyond 1.2 is measured by scaling the input image at the factor of 1/2, 1/3 and 1/4, correlating the artificially scaled input image with the template images, and estimating the new corresponding scale factor inside 0.8~1.2.

Analytical pair correlations in ideal quantum gases: temperature-dependent bunching and antibunching.

Science.gov (United States)

Bosse, J; Pathak, K N; Singh, G S

2011-10-01

The fluctuation-dissipation theorem together with the exact density response spectrum for ideal quantum gases has been utilized to yield a new expression for the static structure factor, which we use to derive exact analytical expressions for the temperature-dependent pair distribution function g(r) of the ideal gases. The plots of bosonic and fermionic g(r) display "Bose pile" and "Fermi hole" typically akin to bunching and antibunching as observed experimentally for ultracold atomic gases. The behavior of spin-scaled pair correlation for fermions is almost featureless, but bosons show a rich structure including long-range correlations near T(c). The coherent state at T=0 shows no correlation at all, just like single-mode lasers. The depicted decreasing trend in correlation with decrease in temperature for T

Decreases in fasting leptin and insulin concentrations after acute energy restriction and subsequent compensation in food intake.

Science.gov (United States)

Mars, Monica; de Graaf, Cees; de Groot, Lisette C P G M; Kok, Frans J

2005-03-01

The decrease in leptin after energy restriction is a starvation signal to the brain. Several studies have found an association between this decrease and subjective appetite; however, no solid data are available on the acute decrease in fasting leptin concentration and subsequent caloric compensation. The objective was to assess the effect of acute decreases in fasting leptin concentrations, induced by energy restriction, on subsequent energy intake compensation. We hypothesized that men with a large decrease in fasting leptin concentrations would have larger ad libitum energy intakes than would men with a small decrease in leptin. Thirty-four male unrestrained eaters [age: 23 +/- 3 y; body mass index (in kg/m(2)): 22.3 +/- 1.6] participated in a semicontrolled intervention study. Fasting serum leptin and insulin concentrations were measured before and 2 d after 62% energy restriction. Energy intake was measured on the 2 following days on which food was provided ad libitum. During energy restriction, fasting leptin and insulin concentrations decreased by 27.2% (95% CI: -34.4%, -19.9%) and 30.7% (95% CI: -41.0%, -20.4%), respectively. Subjects consumed 143 +/- 27% of their estimated energy requirements (18.3 +/- 2.9 MJ) on the first day and 124 +/- 20% (16.0 +/- 2.6 MJ) on the second day of ad libitum intake. No significant correlations were observed between decreases in fasting leptin or insulin concentrations and subsequent ad libitum energy intake; however, decreases in insulin were correlated with an increase in carbohydrate intake (r=-0.49, P < 0.01). Although fasting leptin concentrations decreased significantly during energy restriction and subjects showed compensatory behavior during subsequent ad libitum food intake, no association was observed between the decrease in fasting leptin concentrations and caloric compensation.

Quantum Correlation in Matrix Product States of One-Dimensional Spin Chains

International Nuclear Information System (INIS)

Zhu Jing-Min

2015-01-01

For our proposed composite parity-conserved matrix product state (MPS), if only a spin block length is larger than 1, any two such spin blocks have correlation including classical correlation and quantum correlation. Both the total correlation and the classical correlation become larger than that in any subcomponent; while the quantum correlations of the two nearest-neighbor spin blocks and the two next-nearest-neighbor spin blocks become smaller and for other conditions the quantum correlation becomes larger, i.e., the increase or the production of the long-range quantum correlation is at the cost of reducing the short-range quantum correlation, which deserves to be investigated in the future; and the ration of the quantum correlation to the total correlation monotonically decreases to a steady value as the spacing spin length increasing. (paper)

Mean platelet volume is decreased in adults with active lupus disease

Directory of Open Access Journals (Sweden)

Guillermo Delgado-García

Full Text Available ABSTRACT Background: Only a few biomarkers are available for assessing disease activity in systemic lupus erythematosus (SLE. Mean platelet volume (MPV has been recently studied as an inflammatory biomarker. It is currently unclear whether MPV may also play a role as a biomarker of disease activity in adult patients with SLE. Objective: We investigated the association between MPV and disease activity in adult patients with SLE. Methods: In this retrospective study, we compared two groups of adult patients divided according to disease activity (36 per group. Subjects were age- and gender-matched. Results: MPV was significantly decreased with respect to those of inactive patients (7.16 ± 1.39 vs. 8.16 ± 1.50, p = 0.005. At a cutoff level of 8.32 fL, MPV has a sensitivity of 86% and a specificity of 41% for the detection of disease activity. A modest positive correlation was found between MPV and albumin (r = 0.407, p = 0.001, which in turn is inversely associated with disease activity. Conclusions: In summary, MPV is decreased in adult patients with active lupus disease, and positively correlated with albumin, another biomarker of disease activity. Prospective studies are needed to evaluate the prognostic value of this biomarker.

Mean platelet volume is decreased in adults with active lupus disease.

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Delgado-García, Guillermo; Galarza-Delgado, Dionicio Ángel; Colunga-Pedraza, Iris; Borjas-Almaguer, Omar David; Mandujano-Cruz, Ilse; Benavides-Salgado, Daniel; Martínez-Granados, Rolando Jacob; Atilano-Díaz, Alexandro

Only a few biomarkers are available for assessing disease activity in systemic lupus erythematosus (SLE). Mean platelet volume (MPV) has been recently studied as an inflammatory biomarker. It is currently unclear whether MPV may also play a role as a biomarker of disease activity in adult patients with SLE. We investigated the association between MPV and disease activity in adult patients with SLE. In this retrospective study, we compared two groups of adult patients divided according to disease activity (36 per group). Subjects were age- and gender-matched. MPV was significantly decreased with respect to those of inactive patients (7.16±1.39 vs. 8.16±1.50, p=0.005). At a cutoff level of 8.32fL, MPV has a sensitivity of 86% and a specificity of 41% for the detection of disease activity. A modest positive correlation was found between MPV and albumin (r=0.407, p=0.001), which in turn is inversely associated with disease activity. In summary, MPV is decreased in adult patients with active lupus disease, and positively correlated with albumin, another biomarker of disease activity. Prospective studies are needed to evaluate the prognostic value of this biomarker. Copyright © 2016 Elsevier Editora Ltda. All rights reserved.

Degeneracy and long-range correlation: A simulation study

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Marmelat Vivien

2011-12-01

Full Text Available We present in this paper a simulation study that aimed at evidencing a causal relationship between degeneracy and long-range correlations. Long-range correlations represent a very specific form of fluctuations that have been evidenced in the outcomes time series produced by a number of natural systems. Long-range correlations are supposed to sign the complexity, adaptability and flexibility of the system. Degeneracy is defined as the ability of elements that are structurally different to perform the same function, and is presented as a key feature for explaining the robustness of complex systems. We propose a model able to generate long-range correlated series, and including a parameter that account for degeneracy. Results show that a decrease in degeneracy tends to reduce the strength of long-range correlation in the series produced by the model.

Effects of degree correlation on scale-free gradient networks

International Nuclear Information System (INIS)

Pan Guijun; Yan Xiaoqing; Ma Weichuan; Luo Yihui; Huang Zhongbing

2010-01-01

We have studied the effects of degree correlation on congestion pressure in scale-free gradient networks. It is observed that the jamming coefficient J is insensitive to the degree correlation coefficient r for assortative and strongly disassortative scale-free networks, and J markedly decreases with an increase in r for weakly disassortative scale-free networks. We have also investigated the effects of degree correlation on the topology structure of scale-free gradient networks, and discussed the relation between the topology structure properties and transport efficiency of gradient networks.

The Telemachus mission: dynamics of the polar sun and heliosphere

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Roelof, E.

Telemachus in Greek mythology was the faithful son of Ulysses. The Telemachus mission is envisioned as the next logical step in the exploration of the polar regions of the Sun and heliosphere so excitingly initiated by the ESA/NASA Ulysses mission. Telemachus is a polar solar-heliospheric mission described in the current NASA Sun-Earth Connections Roadmap (2003-2028) that has successfully undergone two Team X studies by NASA/JPL. The pioneering observations from Ulysses transformed our perception of the structure and dynamics of these polar regions through which flow the solar wind, magnetic fields and energetic particles that eventually populate most of the volume of the heliosphere. Ulysses carried only fields and particles detectors. Telemachus, in addition to modern versions of such essential in situ instruments, will carry imagers that will give solar astronomers a new viewpoint on coronal mass ejections and solar flares, as well as their first purely polar views of the photospheric magnetic field, thereby providing new helioseismology to probe the interior of the Sun. Unlike the RTG-powered Ulysses, the power for Telemachus will come simply from solar panels. Gravity assist encounters with Venus and Earth (twice) will yield ˜5 years of continuous in-ecliptic cruise science between 0.7 AU and 3.3 AU that will powerfully complement other contemporary solar-heliospheric missions. The Jupiter gravity assist, followed by a perihelion burn ˜8 years after launch, will place Telemachus in a permanent ˜0.2 AU by 2.5 AU heliographic polar orbit (inclination >80 deg) whose period will be 1.5 years. Telemachus will then pass over the solar poles at ˜0.4 AU (compared to 1.4 AU for Ulysses) and spend ˜2 weeks above 60 deg on each polar pass (alternating perihelions between east and west limbs as viewed from Earth). In 14 polar passes during a 10.5 year solar cycle, Telemachus would accumulate over half a year of polar science data. During the remainder of the time, it

Solar cycle variations of the energetic H/He intensity ratio at high heliolatitudes and in the ecliptic plane

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D. Lario

Full Text Available We study the variability of the heliospheric energetic proton-to-helium abundance ratios during different phases of the solar cycle. We use energetic particle, solar wind, and magnetic field data from the Ulysses, ACE and IMP-8 spacecraft to compare the H/He intensity ratio at high heliographic latitudes and in the ecliptic plane. During the first out-of-ecliptic excursion of Ulysses (1992–1996, the HI-SCALE instrument measured corotating energetic particle intensity enhancements characterized by low values (< 10 of the 0.5–1.0 MeV nucleon^-1 H/He intensity ratio. During the second out-of-ecliptic excursion of Ulysses (1999–2002, the more frequent occurrence of solar energetic particle events resulted in almost continuously high (< 20 values of the H/He ratio, even at the highest heliolatitudes reached by Ulysses. Comparison with in-ecliptic measurements from an identical instrument on the ACE spacecraft showed similar H/He values at ACE and Ulysses, suggesting a remarkable uniformity of energetic particle intensities in the solar maximum heliosphere at high heliolatitudes and in the ecliptic plane. In-ecliptic observations of the H/He intensity ratio from the IMP-8 spacecraft show variations between solar maximum and solar minimum similar to those observed by Ulysses at high heliographic latitudes. We suggest that the variation of the H/He intensity ratio throughout the solar cycle is due to the different level of transient solar activity, as well as the different structure and duration that corotating solar wind structures have under solar maximum and solar minimum conditions. During solar minimum, the interactions between the two different types of solar wind streams (slow vs. fast are strong and long-lasting, allowing for a continuous and efficient acceleration of interstellar pickup He +. During solar maximum, transient events of solar origin (characterized by high values of the H/He ratio are able to globally

Background parenchymal enhancement in breast MRI before and after neoadjuvant chemotherapy: correlation with tumour response

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Preibsch, H.; Wanner, L.; Bahrs, S.D.; Wietek, B.M.; Nikolaou, K.; Wiesinger, B. [University Hospital Tuebingen, Diagnostic and Interventional Radiology, Tuebingen (Germany); Siegmann-Luz, K.C. [Diagnostic Center for Breast Cancer and Screening Mammography Brandenburg Ost, Koenigs Wusterhausen (Germany); Oberlecher, E.; Hahn, M. [University Hospital Tuebingen, Department of Gynecology and Obstetrics, Tuebingen (Germany); Staebler, A. [University Hospital Tuebingen, Institute of Pathology and Neuropathology, Tuebingen (Germany)

2016-06-15

To correlate the decrease in background parenchymal enhancement (BPE) and tumour response measured with MRI in breast cancer patients treated with neoadjuvant chemotherapy (NAC). One hundred and forty-six MRI examinations of 73 patients with 80 biopsy-proven breast cancers who underwent breast MRI before and after NAC were retrospectively analysed. All images were reviewed by two blinded readers, who classified BPE into categories (BEC; 1 = minimal, 2 = mild, 3 = moderate, 4 = marked) before and after NAC. Histopathological and morphological tumour responses were analysed and compared. The distribution of BEC 1/2/3/4 was 25/46/18/11 % before and 78/20/2/0 % after NAC. On average, BPE decreased by 0.87 BEC. Cohen's kappa showed substantial agreement (k = 0.73-0.77) before and moderate agreement (k = 0.43-0.60) after NAC and moderate agreement (k = 0.62-0.60) concerning the change in BEC. Correlating the change in BPE with tumour response, the average decrease in BEC was 1.3 in cases of complete remission, 0.83 in cases with partial response, 0.85 in cases with stable disease and 0.40 in cases with progressive disease. Correlation analysis showed a significant correlation between the decrease in BEC and tumour response (r = -0.24, p = 0.03). BPE decreased by, on average, 0.87 BEC following NAC for breast cancer. The degree of BPE reduction seemed to correlate with tumour response. (orig.)

Long-range correlation and market segmentation in bond market

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Wang, Zhongxing; Yan, Yan; Chen, Xiaosong

2017-09-01

This paper investigates the long-range auto-correlations and cross-correlations in bond market. Based on Detrended Moving Average (DMA) method, empirical results present a clear evidence of long-range persistence that exists in one year scale. The degree of long-range correlation related to maturities has an upward tendency with a peak in short term. These findings confirm the expectations of fractal market hypothesis (FMH). Furthermore, we have developed a method based on a complex network to study the long-range cross-correlation structure and applied it to our data, and found a clear pattern of market segmentation in the long run. We also detected the nature of long-range correlation in the sub-period 2007-2012 and 2011-2016. The result from our research shows that long-range auto-correlations are decreasing in the recent years while long-range cross-correlations are strengthening.

Quantum Correlations Evolution Asymmetry in Quantum Channels

International Nuclear Information System (INIS)

Li Meng; Huang Yun-Feng; Guo Guang-Can

2017-01-01

It was demonstrated that the entanglement evolution of a specially designed quantum state in the bistochastic channel is asymmetric. In this work, we generalize the study of the quantum correlations, including entanglement and quantum discord, evolution asymmetry to various quantum channels. We found that the asymmetry of entanglement and quantum discord only occurs in some special quantum channels, and the behavior of the entanglement evolution may be quite different from the behavior of the quantum discord evolution. To quantum entanglement, in some channels it decreases monotonously with the increase of the quantum channel intensity. In some other channels, when we increase the intensity of the quantum channel, it decreases at first, then keeps zero for some time, and then rises up. To quantum discord, the evolution becomes more complex and you may find that it evolutes unsmoothly at some points. These results illustrate the strong dependence of the quantum correlations evolution on the property of the quantum channels. (paper)

Decreasing Signs of Negative Affect and Correlated Self-Injury in an Individual with Mental Retardation and Mood Disturbances.

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Lindauer, Steven E.; DeLeon, Iser G.; Fisher, Wayne W.

1999-01-01

This study evaluated effects of an enriched environment, based on a paired-choice preference assessment, on rates of self-injurious behavior (SIB) and frequency of negative affect displayed by a woman with mental retardation and a mood disorder. Results suggested that SIB and negative affect were highly correlated and that the enriched environment…

Breastfeeding Is Associated with Decreased Childhood Maltreatment.

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Kremer, Kristen P; Kremer, Theodore R

Child maltreatment has serious implications for youth outcomes, yet its associations with early parenting practices are not fully understood. This study investigated whether breastfeeding practices are correlated with childhood maltreatment. Data were utilized from the National Longitudinal Study of Adolescent to Adult Health, a nationally representative and longitudinal study of adolescents. The analytic sample comprised 4,159 adolescents. The outcome variables included four subtypes of childhood maltreatment (neglect, inadequate supervision, physical abuse, and sexual abuse). The primary independent variable was breastfeeding duration. Covariates of the child, mother, and household were included in analyses. Logistic regression models were employed to predict odds of maltreatment subtypes from breastfeeding duration and covariates. Compared with adolescents never breastfed, adolescents breastfed 9 months or longer had a reduced odds of having experienced neglect (odds ratio [OR] = 0.54; 95% confidence interval [CI] = 0.35-0.83) and sexual abuse (OR = 0.47; 95% CI = 0.24-0.93) after controlling for covariates. Breastfeeding duration is significantly associated with decreased childhood neglect and sexual abuse. Breastfeeding practices should be explored as a consideration among clinicians when assessing maltreatment risk. Further research should examine whether a causal relationship exists between breastfeeding and decreased maltreatment.

The anisotropic Ising correlations as elliptic integrals: duality and differential equations

International Nuclear Information System (INIS)

McCoy, B M; Maillard, J-M

2016-01-01

We present the reduction of the correlation functions of the Ising model on the anisotropic square lattice to complete elliptic integrals of the first, second and third kind, the extension of Kramers–Wannier duality to anisotropic correlation functions, and the linear differential equations for these anisotropic correlations. More precisely, we show that the anisotropic correlation functions are homogeneous polynomials of the complete elliptic integrals of the first, second and third kind. We give the exact dual transformation matching the correlation functions and the dual correlation functions. We show that the linear differential operators annihilating the general two-point correlation functions are factorized in a very simple way, in operators of decreasing orders. (paper)

Serotonin Decreases the Gain of Visual Responses in Awake Macaque V1.

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Seillier, Lenka; Lorenz, Corinna; Kawaguchi, Katsuhisa; Ott, Torben; Nieder, Andreas; Pourriahi, Paria; Nienborg, Hendrikje

2017-11-22

Serotonin, an important neuromodulator in the brain, is implicated in affective and cognitive functions. However, its role even for basic cortical processes is controversial. For example, in the mammalian primary visual cortex (V1), heterogenous serotonergic modulation has been observed in anesthetized animals. Here, we combined extracellular single-unit recordings with iontophoresis in awake animals. We examined the role of serotonin on well-defined tuning properties (orientation, spatial frequency, contrast, and size) in V1 of two male macaque monkeys. We find that in the awake macaque the modulatory effect of serotonin is surprisingly uniform: it causes a mainly multiplicative decrease of the visual responses and a slight increase in the stimulus-selective response latency. Moreover, serotonin neither systematically changes the selectivity or variability of the response, nor the interneuronal correlation unexplained by the stimulus ("noise-correlation"). The modulation by serotonin has qualitative similarities with that for a decrease in stimulus contrast, but differs quantitatively from decreasing contrast. It can be captured by a simple additive change to a threshold-linear spiking nonlinearity. Together, our results show that serotonin is well suited to control the response gain of neurons in V1 depending on the animal's behavioral or motivational context, complementing other known state-dependent gain-control mechanisms. SIGNIFICANCE STATEMENT Serotonin is an important neuromodulator in the brain and a major target for drugs used to treat psychiatric disorders. Nonetheless, surprisingly little is known about how it shapes information processing in sensory areas. Here we examined the serotonergic modulation of visual processing in the primary visual cortex of awake behaving macaque monkeys. We found that serotonin mainly decreased the gain of the visual responses, without systematically changing their selectivity, variability, or covariability. This

Worse Neurological State During Acute Ischemic Stroke is Associated with a Decrease in Serum Albumin Levels.

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Bielewicz, Joanna; Kurzepa, Jacek; Czekajska-Chehab, Elżbieta; Kamieniak, Piotr; Daniluk, Beata; Bartosik-Psujek, Halina; Rejdak, Konrad

2016-04-01

High serum albumin levels during ischemic stroke (IS) decrease the risk of a poor outcome. This study aimed to determine whether serum albumin levels within the first days after IS correlate with radiological and biochemical markers of brain tissue damage. Fifty-six IS patients were enrolled into the study. Neurological examinations were based on the National Institute of Health Stroke Scale. Serum albumin levels and S100BB were evaluated using commercially available ELISA kits. The albumin decrease index (ADI) was calculated as the difference between serum albumin levels measured on days 1 and 10 of IS. All parameters were estimated on the 1st, 3rd, 5th, and 10th days of IS, and the volume of ischemic focus was measured on the 10th day. Mean serum albumin levels were decreased during acute IS. There were correlations between the ADI and mean S100BB serum levels (r = 0.36, p albumin levels during the acute phase of IS corresponds to a worse neurological state as a result of a large ischemic focus with intense catabolic processes.

Analysis of input variables of an artificial neural network using bivariate correlation and canonical correlation

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Costa, Valter Magalhaes; Pereira, Iraci Martinez, E-mail: valter.costa@usp.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

2011-07-01

The monitoring of variables and diagnosis of sensor fault in nuclear power plants or processes industries is very important because a previous diagnosis allows the correction of the fault and, like this, to prevent the production stopped, improving operator's security and it's not provoking economics losses. The objective of this work is to build a set, using bivariate correlation and canonical correlation, which will be the set of input variables of an artificial neural network to monitor the greater number of variables. This methodology was applied to the IEA-R1 Research Reactor at IPEN. Initially, for the input set of neural network we selected the variables: nuclear power, primary circuit flow rate, control/safety rod position and difference in pressure in the core of the reactor, because almost whole of monitoring variables have relation with the variables early described or its effect can be result of the interaction of two or more. The nuclear power is related to the increasing and decreasing of temperatures as well as the amount radiation due fission of the uranium; the rods are controls of power and influence in the amount of radiation and increasing and decreasing of temperatures; the primary circuit flow rate has the function of energy transport by removing the nucleus heat. An artificial neural network was trained and the results were satisfactory since the IEA-R1 Data Acquisition System reactor monitors 64 variables and, with a set of 9 input variables resulting from the correlation analysis, it was possible to monitor 51 variables. (author)

Analysis of input variables of an artificial neural network using bivariate correlation and canonical correlation

International Nuclear Information System (INIS)

Costa, Valter Magalhaes; Pereira, Iraci Martinez

2011-01-01

The monitoring of variables and diagnosis of sensor fault in nuclear power plants or processes industries is very important because a previous diagnosis allows the correction of the fault and, like this, to prevent the production stopped, improving operator's security and it's not provoking economics losses. The objective of this work is to build a set, using bivariate correlation and canonical correlation, which will be the set of input variables of an artificial neural network to monitor the greater number of variables. This methodology was applied to the IEA-R1 Research Reactor at IPEN. Initially, for the input set of neural network we selected the variables: nuclear power, primary circuit flow rate, control/safety rod position and difference in pressure in the core of the reactor, because almost whole of monitoring variables have relation with the variables early described or its effect can be result of the interaction of two or more. The nuclear power is related to the increasing and decreasing of temperatures as well as the amount radiation due fission of the uranium; the rods are controls of power and influence in the amount of radiation and increasing and decreasing of temperatures; the primary circuit flow rate has the function of energy transport by removing the nucleus heat. An artificial neural network was trained and the results were satisfactory since the IEA-R1 Data Acquisition System reactor monitors 64 variables and, with a set of 9 input variables resulting from the correlation analysis, it was possible to monitor 51 variables. (author)

A Transgressão Moderna e Pós-utópica de Ulisses

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Carolina Dônega Bernardes

2009-04-01

Full Text Available Always invoked by the literary tradition, the travel of Ulysses confirms, in some works,the ideal of the nostalgic hero bounded for home in order to achieve his nóstos, and, in other works, it reaffirms the impetus of the eternal sailor. Several are the representations of the last journey of Odyssey, including the Divine Comedy by Dante, Ulysses by Joyce and Odyssey by Nikos Kazantzakis. We intend in this article, to evaluate resumption of Homeric myth by Kazantzakis in the context of modernity and Haroldo de Campos in postmodernity.

Empagliflozin decreases remnant-like particle cholesterol in type 2 diabetes patients with insulin resistance.

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Hattori, Sachiko

2017-11-28

Remnant lipoproteins are thought to be atherogenic. Remnant-like particle cholesterol (RLP-C), which reflects the levels of various kinds of remnant lipoproteins in the blood, has a significant correlation with insulin resistance. In the present study, we measured the effect of empagliflozin (EMPA) on the levels of RLP-C, and investigated whether EMPA-mediated change in RLP-C is associated with a change in insulin resistance in type 2 diabetes patients who have insulin resistance. Patients were allocated to receive a placebo (n = 51) or EMPA (n = 58) as an add-on treatment. Fasting blood samples were collected before and 12 weeks after this intervention. EMPA significantly decreased glycated hemoglobin, bodyweight, systolic blood pressure, plasma triglycerides, liver transaminases and estimated glomerular filtration rate, and increased high-density lipoprotein cholesterol. Furthermore, EMPA decreased RLP-C and homeostatic model assessment of insulin resistance. In the placebo group, there were no significant changes in these factors except for slight increases in liver transaminases. Multiple regression analysis showed that the change in homeostatic model assessment of insulin resistance (P = 0.0102) and the change in alanine aminotransferase (P = 0.0301) were significantly associated with the change in RLP-C in the EMPA group. The change in RLP-C significantly correlated with the change in homeostatic model assessment of insulin resistance (Pearson correlation coefficient 0.503, 95% confidence interval 0.199-0.719; P = 0.00241). EMPA decreases RLP-C levels, which is closely associated with amelioration of insulin sensitivity in diabetes patients who have insulin resistance. © 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

Aging and loss decision making: increased risk aversion and decreased use of maximizing information, with correlated rationality and value maximization.

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Kurnianingsih, Yoanna A; Sim, Sam K Y; Chee, Michael W L; Mullette-Gillman, O'Dhaniel A

2015-01-01

We investigated how adult aging specifically alters economic decision-making, focusing on examining alterations in uncertainty preferences (willingness to gamble) and choice strategies (what gamble information influences choices) within both the gains and losses domains. Within each domain, participants chose between certain monetary outcomes and gambles with uncertain outcomes. We examined preferences by quantifying how uncertainty modulates choice behavior as if altering the subjective valuation of gambles. We explored age-related preferences for two types of uncertainty, risk, and ambiguity. Additionally, we explored how aging may alter what information participants utilize to make their choices by comparing the relative utilization of maximizing and satisficing information types through a choice strategy metric. Maximizing information was the ratio of the expected value of the two options, while satisficing information was the probability of winning. We found age-related alterations of economic preferences within the losses domain, but no alterations within the gains domain. Older adults (OA; 61-80 years old) were significantly more uncertainty averse for both risky and ambiguous choices. OA also exhibited choice strategies with decreased use of maximizing information. Within OA, we found a significant correlation between risk preferences and choice strategy. This linkage between preferences and strategy appears to derive from a convergence to risk neutrality driven by greater use of the effortful maximizing strategy. As utility maximization and value maximization intersect at risk neutrality, this result suggests that OA are exhibiting a relationship between enhanced rationality and enhanced value maximization. While there was variability in economic decision-making measures within OA, these individual differences were unrelated to variability within examined measures of cognitive ability. Our results demonstrate that aging alters economic decision-making for

Aging and loss decision making: increased risk aversion and decreased use of maximizing information, with correlated rationality and value maximization

Directory of Open Access Journals (Sweden)

Yoanna Arlina Kurnianingsih

2015-05-01

Full Text Available We investigated how adult aging specifically alters economic decision-making, focusing on examining alterations in uncertainty preferences (willingness to gamble and choice strategies (what gamble information influences choices within both the gains and losses domains. Within each domain, participants chose between certain monetary outcomes and gambles with uncertain outcomes. We examined preferences by quantifying how uncertainty modulates choice behavior as if altering the subjective valuation of gambles. We explored age-related preferences for two types of uncertainty, risk and ambiguity. Additionally, we explored how aging may alter what information participants utilize to make their choices by comparing the relative utilization of maximizing and satisficing information types through a choice strategy metric. Maximizing information was the ratio of the expected value of the two options, while satisficing information was the probability of winning.We found age-related alterations of economic preferences within the losses domain, but no alterations within the gains domain. Older adults (OA; 61 to 80 years old were significantly more uncertainty averse for both risky and ambiguous choices. OA also exhibited choice strategies with decreased use of maximizing information. Within OA, we found a significant correlation between risk preferences and choice strategy. This linkage between preferences and strategy appears to derive from a convergence to risk neutrality driven by greater use of the effortful maximizing strategy. As utility maximization and value maximization intersect at risk neutrality, this result suggests that OA are exhibiting a relationship between enhanced rationality and enhanced value maximization. While there was variability in economic decision-making measures within OA, these individual differences were unrelated to variability within examined measures of cognitive ability. Our results demonstrate that aging alters economic

Incident energy dependence of pt correlations at relativistic energies

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Adams, J; Ahammed, Z; Amonett, J; Anderson, B D; Arkhipkin, D; Averichev, G S; Badyal, S K; Bai, Y; Balewski, J; Barannikova, O; Barnby, L S; Baudot, J; Bekele, S; Belaga, V V; Bellingeri-Laurikainen, A; Bellwied, R; Berger, J; Bezverkhny, B I; Bharadwaj, S; Bhasin, A; Bhati, A K; Bhatia, V S; Bichsel, H; Bielcik, J; Bielcikova, J; Billmeier, A; Bland, L C; Blyth, C O; Bonner, B E; Botje, M; Boucham, A; Bouchet, J; Brandin, A V; Bravar, A; Bystersky, M; Cadman, R V; Cai, X Z; Caines, H; Calderón de la Barca-Sanchez, M; Castillo, J; Catu, O; Cebra, D; Chajecki, Z; Chaloupka, P; Chattopadhyay, S; Chen, H F; Chen, Y; Cheng, J; Cherney, M; Chikanian, A; Christie, W; Coffin, J P; Cormier, T M; Cramer, J G; Crawford, H J; Das, D; Das, S; Daugherity, M; De Moura, M M; Dedovich, T G; Derevshchikov, A A; Didenko, L; Dietel, T; Dogra, S M; Dong, W J; Dong, X; Draper, J E; Du, F; Dubey, A K; Dunin, V B; Dunlop, J C; Dutta, M R; Mazumdar; Eckardt, V; Edwards, W R; Efimov, L G; Emelianov, V; Engelage, J; Eppley, G; Erazmus, B; Estienne, M; Fachini, P; Faivre, J; Fatemi, R; Fedorisin, J; Filimonov, K; Filip, P; Finch, E; Fine, V; Fisyak, Yu; Fu, J; Gagliardi, C A; Gaillard, L; Gans, J; Ganti, M S; Geurts, F; Ghazikhanian, V; Ghosh, P; González, J E; Gos, H; Grachov, O; Grebenyuk, O; Grosnick, D P; Guertin, S M; Guo, Y; Sen-Gupta, A; Gutíerrez, T D; Hallman, T J; Hamed, A; Hardtke, D; Harris, J W; Heinz, M; Henry, T W; Hepplemann, S; Hippolyte, B; Hirsch, A; Hjort, E; Hoffmann, G W; Huang, H Z; Huang, S L; Hughes, E W; Humanic, T J; Igo, G; Ishihara, A; Jacobs, P; Jacobs, W W; Jedynak, M; Jiang, H; Jones, P G; Judd, E G; Kabana, S; Kang, K; Kaplan, M; Keane, D; Kechechyan, A; Khodyrev, V Yu; Kiryluk, J; Kisiel, A; Kislov, E M; Klay, J; Klein, S R; Koetke, D D; Kollegger, T; Kopytine, M; Kotchenda, L; Kowalik, K L; Krämer, M; Kravtsov, P; Kravtsov, V I; Krüger, K; Kuhn, C; Kulikov, A I; Kumar, A; Kutuev, R K; Kuznetsov, A A; Lamont, M A C; Landgraf, J M; Lange, S; Laue, F; Lauret, J; Lebedev, A; Lednicky, R; Lehocka, S; Le Vine, M J; Li, C; Li, Q; Li, Y; Lin, G; Lindenbaum, S J; Lisa, M A; Liu, F; Liu, H; Liu, L; Liu, Q J; Liu, Z; Ljubicic, T; Llope, W J; Long, H; Longacre, R S; López-Noriega, M; Love, W A; Lu, Y; Ludlam, T; Lynn, D; Ma, G L; Ma, J G; Ma, Y G; Magestro, D; Mahajan, S; Mahapatra, D P; Majka, R; Mangotra, L K; Manweiler, R; Margetis, S; Markert, C; Martin, L; Marx, J N; Matis, H S; Matulenko, Yu A; McClain, C J; McShane, T S; Meissner, F; Melnik, Yu M; Meschanin, A; Miller, M L; Minaev, N G; Mironov, C; Mischke, A; Mishra, D K; Mitchell, J; Mohanty, B; Molnár, L; Moore, C F; Morozov, D A; Munhoz, M G; Nandi, B K; Nayak, S K; Nayak, T K; Nelson, J M; Netrakanti, P K; Nikitin, V A; Nogach, L V; Nurushev, S B; Odyniec, Grazyna Janina; Ogawa, A; Okorokov, V; Oldenburg, M; Olson, D; Pal, S K; Panebratsev, Yu A; Panitkin, S Y; Pavlinov, A I; Pawlak, T; Peitzmann, T; Perevozchikov, V; Perkins, C; Peryt, W; Petrov, V A; Phatak, S C; Picha, R; Planinic, M; Pluta, J; Porile, N; Porter, J; Poskanzer, A M; Potekhin, M V; Potrebenikova, E V; Potukuchi, B V K S; Prindle, D; Pruneau, C A; Putschke, J; Rakness, G; Raniwala, R; Raniwala, S; Ravel, O; Ray, R L; Razin, S V; Reichhold, D M; Reid, J G; Reinnarth, J; Renault, G; Retière, F; Ridiger, A; Ritter, H G; Roberts, J B; Rogachevski, O V; Romero, J L; Rose, A; Roy, C; Ruan, L; Russcher, M; Sahoo, R; Sakrejda, I; Salur, S; Sandweiss, J; Sarsour, M; Savin, I; Sazhin, P S; Schambach, J; Scharenberg, R P; Schmitz, N; Schweda, K; Seger, J; Seyboth, P; Shahaliev, E; Shao, M; Shao, W; Sharma, M; Shen, W Q; Shestermanov, K E; Shimansky, S S; Sichtermann, E P; Simon, F; Singaraju, R N; Smirnov, N; Snellings, R; Sood, G; Sørensen, P; Sowinski, J; Speltz, J; Spinka, H M; Srivastava, B; Stadnik, A; Stanislaus, T D S; Stock, R; Stolpovsky, A; Strikhanov, M N; Stringfellow, B C; Suaide, A A P; Sugarbaker, E R; Suire, C; Sumbera, M; Surrow, B; Swanger, M; Symons, T J M; Szanto de Toledo, A; Tai, A; Takahashi, J; Tang, A H; Tarnowsky, T J; Thein, D; Thomas, J H; Timoshenko, S; Tokarev, M; Trentalange, S; Tribble, R E; Tsai, O D; Ulery, J; Ullrich, T; Underwood, D G; Van Buren, G; Van Leeuwen, M; Van der Molen, A M; Varma, R; Vasilevski, I M; Vasilev, A N; Vernet, R; Vigdor, S E; Viyogi, Y P; Vokal, S; Voloshin, S A; Waggoner, W T; Wang, F; Wang, G; Wang, X L; Wang, Y; Wang, Z M; Ward, H; Watson, J W; Webb, J C; Westfall, G D; Wetzler, A; Whitten, C; Wieman, H; Wissink, S W; Witt, R; Wood, J; Wu, J; Xu, N; Xu, Z; Xu, Z Z; Yamamoto, E; Yepes, P; Yurevich, V I; Zborovský, I; Zhang, H; Zhang, W M; Zhang, Y; Zhang, Z P; Zoulkarneev, R; Zoulkarneeva, Y; Zubarev, A N

2005-01-01

We present results for two-particle transverse momentum correlations, , as a function of event centrality for Au+Au collisions at sqrt(sNN) = 20, 62, 130, and 200 GeV at the Relativistic Heavy Ion Collider. We observe correlations decreasing with centrality that are similar at all four incident energies. The correlations multiplied by the multiplicity density increase with incident energy and the centrality dependence may show evidence of processes such as thermalization, minijet production, or the saturation of transverse flow. The square root of the correlations divided by the event-wise average transverse momentum per event shows little or no beam energy dependence and generally agrees with previous measurements at the Super Proton Synchrotron.

Effects of magnetic correlation on the electric properties in multiferroic materials

International Nuclear Information System (INIS)

Zhai, Liang-Jun; Wang, Huai-Yu

2015-01-01

The effects of magnetic correlation on the electric properties in the multiferroic materials are studied, where the phase transition temperature of the magnetic subsystem T m is lower than that of the electric subsystem T e . A Heisenberg-type Hamiltonian and a transverse Ising model are employed to describe the ferromagnetic and ferroelectric subsystems, respectively. We find that the magnetic correlation can influence the electric properties above the T m , and magnetic transverse and longitudinal correlations have opposite functions. In the curves of temperature dependence of polarization, kinks appear at T m which is dominated by the sharp change of decreasing rate of the magnetic correlation. The kinks can be eliminated by an external magnetic field. The magnetic transverse and longitudinal correlations play contrary roles on the manipulation of polarization by the external magnetic field. - Highlights: • Both magnetic longitudinal and transverse correlations can influence the electric subsystem through magnetoelectric (ME) coupling at any temperature. • The magnetic longitudinal and transverse correlations have contrary effects in influencing the phase transition temperature of electric subsystem. • The electric phase transition temperature decrease with the ME coupling strength, while it was not so by mean-field theory. • An external field can make the influence smoother around the transition point, and can enhance the electric polarization. • Magnetic longitudinal and transverse correlations have contrary effects on the manipulation of polarization by magnetic field at temperature above the magnetic phase transition point

Environmental enrichment decreases asphyxia-induced neurobehavioral developmental delay in neonatal rats.

Science.gov (United States)

Kiss, Peter; Vadasz, Gyongyver; Kiss-Illes, Blanka; Horvath, Gabor; Tamas, Andrea; Reglodi, Dora; Koppan, Miklos

2013-11-13

Perinatal asphyxia during delivery produces long-term disability and represents a major problem in neonatal and pediatric care. Numerous neuroprotective approaches have been described to decrease the effects of perinatal asphyxia. Enriched environment is a popular strategy to counteract nervous system injuries. The aim of the present study was to investigate whether enriched environment is able to decrease the asphyxia-induced neurobehavioral developmental delay in neonatal rats. Asphyxia was induced in ready-to-deliver mothers by removing the pups by caesarian section after 15 min of asphyxia. Somatic and neurobehavioral development was tested daily and motor coordination weekly. Our results show that rats undergoing perinatal asphyxia had a marked developmental delay and worse performance in motor coordination tests. However, pups kept in enriched environment showed a decrease in the developmental delay observed in control asphyctic pups. Rats growing up in enriched environment did not show decrease in weight gain after the first week and the delay in reflex appearance was not as marked as in control rats. In addition, the development of motor coordination was not as strikingly delayed as in the control group. Short-term neurofunctional outcome are known to correlate with long-term deficits. Our results thus show that enriched environment could be a powerful strategy to decrease the deleterious developmental effects of perinatal asphyxia.

Analysis of input variables of an artificial neural network using bivariate correlation and canonical correlation

International Nuclear Information System (INIS)

Costa, Valter Magalhaes

2011-01-01

The monitoring of variables and diagnosis of sensor fault in nuclear power plants or processes industries is very important because an early diagnosis allows the correction of the fault and, like this, do not cause the production interruption, improving operator's security and it's not provoking economics losses. The objective of this work is, in the whole of all variables monitor of a nuclear power plant, to build a set, not necessary minimum, which will be the set of input variables of an artificial neural network and, like way, to monitor the biggest number of variables. This methodology was applied to the IEA-R1 Research Reactor at IPEN. For this, the variables Power, Rate of flow of primary circuit, Rod of control/security and Difference in pressure in the core of the reactor ( Δ P) was grouped, because, for hypothesis, almost whole of monitoring variables have relation with the variables early described or its effect can be result of the interaction of two or more. The Power is related to the increasing and decreasing of temperatures as well as the amount radiation due fission of the uranium; the Rods are controls of power and influence in the amount of radiation and increasing and decreasing of temperatures and the Rate of flow of primary circuit has function of the transport of energy by removing of heat of the nucleus Like this, labeling B= {Power, Rate of flow of Primary Circuit, Rod of Control/Security and Δ P} was computed the correlation between B and all another variables monitoring (coefficient of multiple correlation), that is, by the computer of the multiple correlation, that is tool of Theory of Canonical Correlations, was possible to computer how much the set B can predict each variable. Due the impossibility of a satisfactory approximation by B in the prediction of some variables, it was included one or more variables that have high correlation with this variable to improve the quality of prediction. In this work an artificial neural network

Patient-Reported Disability Measures Do Not Correlate with Electrodiagnostic Severity in Carpal Tunnel Syndrome

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Jacob E. Tulipan, MD

2017-08-01

Conclusions:. Electrodiagnostic severity grades do not correlate with patient-reported disability, including the DASH and MCS–12 surveys. There is a counterintuitive correlation between more-severe electrodiagnostic findings and decreased physical disability. These findings indicate that disability may not correlate with electrodiagnostic severity of median neuropathy in CTS.

Decreased 133Xe clearance in the proximal femur in acromegaly

International Nuclear Information System (INIS)

Kapitola, J.; Marek, J.; Jahoda, I.; Vilimovska, D.

1986-01-01

Using the 133 Xe tissue clearance method, the blood flow in the greater trochanter of the femur was studied in 30 patients with acromegaly. Both the washout rate constant (k 2 ) and blood flow (P 2 ) values are significantly decreased in acromegaly (p < 0.01). There is a significant negative correlation (r = -0.42, p < 0.05) between the flow values and mean daily concentrations of growth hormone in serum of acromegalic patients. The observation is presented as a preliminary evidence of a possible influence of growth hormone on the blood flow in bone. (author)

Decrease in gamma-band activity tracks sequence learning

Science.gov (United States)

Madhavan, Radhika; Millman, Daniel; Tang, Hanlin; Crone, Nathan E.; Lenz, Fredrick A.; Tierney, Travis S.; Madsen, Joseph R.; Kreiman, Gabriel; Anderson, William S.

2015-01-01

Learning novel sequences constitutes an example of declarative memory formation, involving conscious recall of temporal events. Performance in sequence learning tasks improves with repetition and involves forming temporal associations over scales of seconds to minutes. To further understand the neural circuits underlying declarative sequence learning over trials, we tracked changes in intracranial field potentials (IFPs) recorded from 1142 electrodes implanted throughout temporal and frontal cortical areas in 14 human subjects, while they learned the temporal-order of multiple sequences of images over trials through repeated recall. We observed an increase in power in the gamma frequency band (30–100 Hz) in the recall phase, particularly in areas within the temporal lobe including the parahippocampal gyrus. The degree of this gamma power enhancement decreased over trials with improved sequence recall. Modulation of gamma power was directly correlated with the improvement in recall performance. When presenting new sequences, gamma power was reset to high values and decreased again after learning. These observations suggest that signals in the gamma frequency band may play a more prominent role during the early steps of the learning process rather than during the maintenance of memory traces. PMID:25653598

Social contagions on correlated multiplex networks

Science.gov (United States)

Wang, Wei; Cai, Meng; Zheng, Muhua

2018-06-01

The existence of interlayer degree correlations has been disclosed by abundant multiplex network analysis. However, how they impose on the dynamics of social contagions are remain largely unknown. In this paper, we propose a non-Markovian social contagion model in multiplex networks with inter-layer degree correlations to delineate the behavior spreading, and develop an edge-based compartmental (EBC) theory to describe the model. We find that multiplex networks promote the final behavior adoption size. Remarkably, it can be observed that the growth pattern of the final behavior adoption size, versus the behavioral information transmission probability, changes from discontinuous to continuous once decreasing the behavior adoption threshold in one layer. We finally unravel that the inter-layer degree correlations play a role on the final behavior adoption size but have no effects on the growth pattern, which is coincidence with our prediction by using the suggested theory.

General correlation and partial correlation analysis in finding interactions: with Spearman rank correlation and proportion correlation as correlation measures

OpenAIRE

WenJun Zhang; Xin Li

2015-01-01

Between-taxon interactions can be detected by calculating the sampling data of taxon sample type. In present study, Spearman rank correlation and proportion correlation are chosen as the general correlation measures, and their partial correlations are calculated and compared. The results show that for Spearman rank correlation measure, in all predicted candidate direct interactions by partial correlation, about 16.77% (x, 0-45.4%) of them are not successfully detected by Spearman rank correla...

Groundwater travel time uncertainty analysis. Sensitivity of results to model geometry, and correlations and cross correlations among input parameters

International Nuclear Information System (INIS)

Clifton, P.M.

1985-03-01

This study examines the sensitivity of the travel time distribution predicted by a reference case model to (1) scale of representation of the model parameters, (2) size of the model domain, (3) correlation range of log-transmissivity, and (4) cross correlations between transmissivity and effective thickness. The basis for the reference model is the preliminary stochastic travel time model previously documented by the Basalt Waste Isolation Project. Results of this study show the following. The variability of the predicted travel times can be adequately represented when the ratio between the size of the zones used to represent the model parameters and the log-transmissivity correlation range is less than about one-fifth. The size of the model domain and the types of boundary conditions can have a strong impact on the distribution of travel times. Longer log-transmissivity correlation ranges cause larger variability in the predicted travel times. Positive cross correlation between transmissivity and effective thickness causes a decrease in the travel time variability. These results demonstrate the need for a sound conceptual model prior to conducting a stochastic travel time analysis

Ticagrelor Improves Endothelial Function by Decreasing Circulating Epidermal Growth Factor (EGF

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Francesco Vieceli Dalla Sega

2018-04-01

Full Text Available Ticagrelor is one of the most powerful P2Y12 inhibitor. We have recently reported that, in patients with concomitant Stable Coronary Artery Disease (SCAD and Chronic Obstructive Pulmonary Disease (COPD undergoing percutaneous coronary intervention (PCI, treatment with ticagrelor, as compared to clopidogrel, is associated with an improvement of the endothelial function (Clinical Trial NCT02519608. In the present study, we showed that, in the same population, after 1 month treatment with ticagrelor, but not with clopidogrel, there is a decrease of the circulating levels of epidermal growth factor (EGF and that these changes in circulating levels of EGF correlate with on-treatment platelet reactivity. Furthermore, in human umbilical vein endothelial cells (HUVEC incubated with sera of the patients treated with ticagrelor, but not with clopidogrel there is an increase of p-eNOS levels. Finally, analyzing the changes in EGF and p-eNOS levels after treatment, we observed an inverse correlation between p-eNOS and EGF changes only in the ticagrelor group. Causality between EGF and eNOS activation was assessed in vitro in HUVEC where we showed that EGF decreases eNOS activity in a dose dependent manner. Taken together our data indicate that ticagrelor improves endothelial function by lowering circulating EGF that results in the activation of eNOS in the vascular endothelium.

BACODINE/3rd Interplanetary Network burst localization

International Nuclear Information System (INIS)

Hurley, K.; Barthelmy, S.; Butterworth, P.; Cline, T.; Sommer, M.; Boer, M.; Niel, M.; Kouveliotou, C.; Fishman, G.; Meegan, C.

1996-01-01

Even with only two widely separated spacecraft (Ulysses and GRO), 3rd Interplanetary Network (IPN) localizations can reduce the areas of BATSE error circles by two orders of magnitude. Therefore it is useful to disseminate them as quickly as possible following BATSE bursts. We have implemented a system which transmits the light curves of BACODINE/BATSE bursts directly by e-mail to UC Berkeley immediately after detection. An automatic e-mail parser at Berkeley watches for these notices, determines the Ulysses crossing time window, and initiates a search for the burst data on the JPL computer as they are received. In ideal cases, it is possible to retrieve the Ulysses data within a few hours of a burst, generate an annulus of arrival directions, and e-mail it out to the astronomical community by local nightfall. Human operators remain in this loop, but we are developing a fully automated routine which should remove them, at least for intense events, and reduce turn-around times to an absolute minimum. We explain the current operations, the data types used, and the speed/accuracy tradeoffs

Prevention measures and socio-economic development result in a decrease in malaria in Hainan, China.

Science.gov (United States)

Wang, Shan-Qing; Li, Yu-Chun; Zhang, Zhi-Ming; Wang, Guang-Ze; Hu, Xi-Min; Qualls, Whitney A; Xue, Rui-De

2014-09-15

Historically, the incidence of malaria in the Hainan Province, China has been high. However, since 2001 the malaria incidence in Hainan has decreased due to large-scale, public educational, promotional campaigns and the adoption of preventative measures against malaria following the fast growth of socio-economic development. The present study analysed the correlation between prevention measures and social economic development on the incidence of malaria in Hainan from 2001 to 2013. The data of malaria preventative measures and socio-economic development were collected from various cities and counties in Hainan Province from 2001 to 2013 and analysed by the grey correlation analysis system. Seasonal preventive medication and local fiscal revenue increases are significantly related to the reduction of malaria incidence from 2001 to 2013 (R1 = 0.751677; R5 = 0.764795). Malaria prevention and control measures and local economic development in Hainan decreased malaria incidence from 2001 to 2013.

Nutlin-3a decreases male fertility via UQCRC2.

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Kamla Kant Shukla

Full Text Available Ubiquinol-cytochrome-c reductase core protein 2 (UQCRC2 is a component of ubiquinol-cytochrome c reductase complex that is known to correlate with male fertility via spermatogenesis. Simultaneously, nutlin-3a is a small molecule antagonist of mouse double minute 2 repressor (MDM2, activate p53 and induce apoptosis responsible for spermatogenesis. To date, however there are no known effects of nutlin-3a on reproduction. Therefore, present study was designed to investigate the effect of nutlin-3a on male fertility via UQCRC2. In this in vitro trial with mice spermatozoa, we utilized CASA, CTC staining, ATP assay, western blotting, and IVF to measure the main study outcome. The short-term exposure of spermatozoa in nutlin-3a decreases sperm motion kinematics, intracellular ATP production, capacitation, the acrosome reaction, UQCRC2, and tyrosine phosphorylation (TYP of sperm proteins in a dose-dependent manner. Notably, the decreased UQCRC2 and TYP were associated with reduced sperm kinematics, ATP production, and capacitation, which ultimately led to adverse effects on male fertility such as poor fertilization rates and embryo development. Thus, nutlin-3a may be considered as a potential male contraceptive agent due to its ability to decrease fertility secondary to changes in overall sperm physiology and embryonic development. However, the results of this preliminary study have to be confirmed by additional independent trial.

Magnetic flux density in the heliosphere through several solar cycles

Energy Technology Data Exchange (ETDEWEB)

Erdős, G. [Wigner Research Centre for Physics, Hungarian Academy of Sciences, P.O. Box 49, H-1525 Budapest (Hungary); Balogh, A., E-mail: erdos.geza@wigner.mta.hu [The Blackett Laboratory, Imperial College London, London SW7 2BZ (United Kingdom)

2014-01-20

We studied the magnetic flux density carried by solar wind to various locations in the heliosphere, covering a heliospheric distance range of 0.3-5.4 AU and a heliolatitudinal range from 80° south to 80° north. Distributions of the radial component of the magnetic field, B{sub R} , were determined over long intervals from the Helios, ACE, STEREO, and Ulysses missions, as well as from using the 1 AU OMNI data set. We show that at larger distances from the Sun, the fluctuations of the magnetic field around the average Parker field line distort the distribution of B{sub R} to such an extent that the determination of the unsigned, open solar magnetic flux density from the average (|B{sub R} |) is no longer justified. We analyze in detail two methods for reducing the effect of fluctuations. The two methods are tested using magnetic field and plasma velocity measurements in the OMNI database and in the Ulysses observations, normalized to 1 AU. It is shown that without such corrections for the fluctuations, the magnetic flux density measured by Ulysses around the aphelion phase of the orbit is significantly overestimated. However, the matching between the in-ecliptic magnetic flux density at 1 AU (OMNI data) and the off-ecliptic, more distant, normalized flux density by Ulysses is remarkably good if corrections are made for the fluctuations using either method. The main finding of the analysis is that the magnetic flux density in the heliosphere is fairly uniform, with no significant variations having been observed either in heliocentric distance or heliographic latitude.

THE PLASMA ENVIRONMENT IN COMETS OVER A WIDE RANGE OF HELIOCENTRIC DISTANCES: APPLICATION TO COMET C/2006 P1 (MCNAUGHT)

Energy Technology Data Exchange (ETDEWEB)

Shou, Y.; Combi, M.; Gombosi, T.; Toth, G. [Department of Atmospheric, Oceanic and Space Sciences, University of Michigan, Ann Arbor, MI (United States); Jia, Y.-D. [IGPP, and EPSS, University of California, Los Angeles, CA 90095 (United States); Rubin, M. [Physikalisches Institut, University of Bern, Sidlerstrasse. 5, CH-3012 Bern (Switzerland)

2015-08-20

On 2007 January 12, comet C/2006 P1 (McNaught) passed its perihelion at 0.17 AU. Abundant remote observations offer plenty of information on the neutral composition and neutral velocities within 1 million kilometers of the comet nucleus. In early February, the Ulysses spacecraft made an in situ measurement of the ion composition, plasma velocity, and magnetic field when passing through the distant ion tail and the ambient solar wind. The measurement by Ulysses was made when the comet was at around 0.8 AU. With the constraints provided by remote and in situ observations, we simulated the plasma environment of Comet C/2006 P1 (McNaught) using a multi-species comet MHD model over a wide range of heliocentric distances from 0.17 to 1.75 AU. The solar wind interaction of the comet at various locations is characterized and typical subsolar standoff distances of the bow shock and contact surface are presented and compared to analytic solutions. We find the variation in the bow shock standoff distances at different heliocentric distances is smaller than the contact surface. In addition, we modified the multi-species model for the case when the comet was at 0.7 AU and achieved comparable water group ion abundances, proton densities, plasma velocities, and plasma temperatures to the Ulysses/SWICS and SWOOPS observations. We discuss the dominating chemical reactions throughout the comet-solar wind interaction region and demonstrate the link between the ion composition near the comet and in the distant tail as measured by Ulysses.

THE PLASMA ENVIRONMENT IN COMETS OVER A WIDE RANGE OF HELIOCENTRIC DISTANCES: APPLICATION TO COMET C/2006 P1 (MCNAUGHT)

International Nuclear Information System (INIS)

Shou, Y.; Combi, M.; Gombosi, T.; Toth, G.; Jia, Y.-D.; Rubin, M.

2015-01-01

On 2007 January 12, comet C/2006 P1 (McNaught) passed its perihelion at 0.17 AU. Abundant remote observations offer plenty of information on the neutral composition and neutral velocities within 1 million kilometers of the comet nucleus. In early February, the Ulysses spacecraft made an in situ measurement of the ion composition, plasma velocity, and magnetic field when passing through the distant ion tail and the ambient solar wind. The measurement by Ulysses was made when the comet was at around 0.8 AU. With the constraints provided by remote and in situ observations, we simulated the plasma environment of Comet C/2006 P1 (McNaught) using a multi-species comet MHD model over a wide range of heliocentric distances from 0.17 to 1.75 AU. The solar wind interaction of the comet at various locations is characterized and typical subsolar standoff distances of the bow shock and contact surface are presented and compared to analytic solutions. We find the variation in the bow shock standoff distances at different heliocentric distances is smaller than the contact surface. In addition, we modified the multi-species model for the case when the comet was at 0.7 AU and achieved comparable water group ion abundances, proton densities, plasma velocities, and plasma temperatures to the Ulysses/SWICS and SWOOPS observations. We discuss the dominating chemical reactions throughout the comet-solar wind interaction region and demonstrate the link between the ion composition near the comet and in the distant tail as measured by Ulysses

Correlation between BMI and motor coordination in children.

Science.gov (United States)

Lopes, Vítor P; Stodden, David F; Bianchi, Mafalda M; Maia, Jose A R; Rodrigues, Luis P

2012-01-01

To analyze the association between motor coordination (MC) and body mass index (BMI) across childhood and early adolescence. This study is cross-sectional. Data were collected in 7175 children (boys n=3616, girls n=3559), ages 6-14 years. BMI was calculated from measured height and weight [body mass (kg)/height (m(2))]. Motor coordination was evaluated using Kiphard-Schilling's body coordination test (KTK). Spearman's rank correlation was used to study the association between BMI and MC. A Kruskal-Wallis test was used to analyze the differences in MC between children of normal weight, overweight and obese children. Correlations between MC and BMI were negative and varied between 0.05 and 0.49. The highest negative correlations for both boys and girls was at 11 years of age. There was a general pattern of increasing negative correlations in both genders from 6 to 11 years of age and then a decrease in correlation strengths through 14 years of age. In both boys (χ(2)((2))=324.01; p<0.001) and girls (χ(2)((2))=291.20; p<0.001) there were significant differences in MC between the three groups' weight status. Normal weight children of both sexes demonstrated significantly higher MC scores than overweight. Obese children in both sexes had the lowest MC scores among all three groups. Motor coordination demonstrated an inverse relationship with BMI across childhood and into early adolescence. The strength of the inverse relation increased during childhood, but decreased through early adolescence. Overweight and obese children of both sexes demonstrated significantly lower MC than normal weight children. Copyright © 2011 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

Correlation length estimation in a polycrystalline material model

International Nuclear Information System (INIS)

Simonovski, I.; Cizelj, L.

2005-01-01

This paper deals with the correlation length estimated from a mesoscopic model of a polycrystalline material. The correlation length can be used in some macroscopic material models as a material parameter that describes the internal length. It can be estimated directly from the strain and stress fields calculated from a finite-element model, which explicitly accounts for the selected mesoscopic features such as the random orientation, shape and size of the grains. A crystal plasticity material model was applied in the finite-element analysis. Different correlation lengths were obtained depending on the used set of crystallographic orientations. We determined that the different sets of crystallographic orientations affect the general level of the correlation length, however, as the external load is increased the behaviour of correlation length is similar in all the analyzed cases. The correlation lengths also changed with the macroscopic load. If the load is below the yield strength the correlation lengths are constant, and are slightly higher than the average grain size. The correlation length can therefore be considered as an indicator of first plastic deformations in the material. Increasing the load above the yield strength creates shear bands that temporarily increase the values of the correlation lengths calculated from the strain fields. With a further load increase the correlation lengths decrease slightly but stay above the average grain size. (author)

Does red noise increase or decrease extinction risk? Single extreme events versus series of unfavorable conditions.

Science.gov (United States)

Schwager, Monika; Johst, Karin; Jeltsch, Florian

2006-06-01

Recent theoretical studies have shown contrasting effects of temporal correlation of environmental fluctuations (red noise) on the risk of population extinction. It is still debated whether and under which conditions red noise increases or decreases extinction risk compared with uncorrelated (white) noise. Here, we explain the opposing effects by introducing two features of red noise time series. On the one hand, positive autocorrelation increases the probability of series of poor environmental conditions, implying increasing extinction risk. On the other hand, for a given time period, the probability of at least one extremely bad year ("catastrophe") is reduced compared with white noise, implying decreasing extinction risk. Which of these two features determines extinction risk depends on the strength of environmental fluctuations and the sensitivity of population dynamics to these fluctuations. If extreme (catastrophic) events can occur (strong noise) or sensitivity is high (overcompensatory density dependence), then temporal correlation decreases extinction risk; otherwise, it increases it. Thus, our results provide a simple explanation for the contrasting previous findings and are a crucial step toward a general understanding of the effect of noise color on extinction risk.

Astrocytosis measured by {sup 11}C-deprenyl PET correlates with decrease in gray matter density in the parahippocampus of prodromal Alzheimer's patients

Energy Technology Data Exchange (ETDEWEB)

Choo, IL Han [Karolinska Institutet, Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Stockholm (Sweden); Chosun University, Department of Neuropsychiatry, School of Medicine, Gwangju (Korea, Republic of); Carter, Stephen F. [Karolinska Institutet, Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Stockholm (Sweden); Manchester University, Wolfson Imaging Center, Manchester (United Kingdom); Schoell, Michael L. [Karolinska Institutet, Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Stockholm (Sweden); Gothenburg University, Med Tech West, Department of Neuroscience and Rehabilitation, Gothenburg (Sweden); Nordberg, Agneta [Karolinska Institutet, Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Stockholm (Sweden); Karolinska University Hospital Huddinge, Department of Geriatric Medicine, Stockholm (Sweden); Karolinska Institutet, Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Huddinge (Sweden)

2014-11-15

The Alzheimer's disease (AD) pathology is characterized by fibrillar amyloid deposits and neurofibrillary tangles, as well as the activation of astrocytosis, microglia activation, atrophy, dysfunctional synapse, and cognitive impairments. The aim of this study was to test the hypothesis that astrocytosis is correlated with reduced gray matter density in prodromal AD. Twenty patients with AD or mild cognitive impairment (MCI) underwent multi-tracer positron emission tomography (PET) studies with {sup 11}C-Pittsburgh compound B ({sup 11}C-PIB), {sup 18}F-Fluorodeoxyglucose ({sup 18}F-FDG), and {sup 11}C-deuterium-L-deprenyl ({sup 11}C-DED) PET imaging, as well as magnetic resonance imaging (MRI) scanning, cerebrospinal fluid (CSF) biomarker analysis, and neuropsychological assessments. The parahippocampus was selected as a region of interest, and each value was calculated for four different imaging modalities. Correlation analysis was applied between DED slope values and gray matter (GM) densities by MRI. To further explore possible relationships, correlation analyses were performed between the different variables, including the CSF biomarker. A significant negative correlation was obtained between DED slope values and GM density in the parahippocampus in PIB-positive (PIB + ve) MCI patients (p = 0.025) (prodromal AD). Furthermore, in exploratory analyses, a positive correlation was observed between PIB-PET retention and DED binding in AD patients (p = 0.014), and a negative correlation was observed between PIB retention and CSF Aβ42 levels in MCI patients (p = 0.021), while the GM density and CSF total tau levels were negatively correlated in both PIB + ve MCI (p = 0.002) and MCI patients (p = 0.001). No significant correlation was observed with FDG-PET and with any of the other PET, MRI, or CSF biomarkers. High astrocytosis levels in the parahippocampus of PIB + ve MCI (prodromal AD) patients suggest an early preclinical influence on cellular tissue loss. The

Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects

Directory of Open Access Journals (Sweden)

Giordano Elena

2011-01-01

Full Text Available Abstract We have previously shown that krill oil (KO, more efficiently than fish oil, was able to downregulate the endocannabinoid system in different tissues of obese zucker rats. We therefore aimed at investigating whether an intake of 2 g/d of either KO or menhaden oil (MO, which provides 309 mg/d of EPA/DHA 2:1 and 390 mg/d of EPA/DHA 1:1 respectively, or olive oil (OO for four weeks, is able to modify plasma endocannabinoids in overweight and obese subjects. The results confirmed data in the literature describing increased levels of endocannabinoids in overweight and obese with respect to normo-weight subjects. KO, but not MO or OO, was able to significantly decrease 2-arachidonoylglycerol (2-AG, although only in obese subjects. In addition, the decrease of 2-AG was correlated to the plasma n-6/n-3 phospholipid long chain polyunsaturated fatty acid (LCPUFA ratio. These data show for the first time in humans that relatively low doses of LCPUFA n-3 as KO can significantly decrease plasma 2-AG levels in obese subjects in relation to decrease of plasma phospholipid n-6/n-3 LCPUFA ratio. This effect is not linked to changes of metabolic syndrome parameters but is most likely due to a decrease of 2-AG biosynthesis caused by the replacement of 2-AG ultimate precursor, arachidonic acid, with n-3 PUFAs, as previously described in obese Zucker rats.

CORRELATION OF HARD X-RAY AND WHITE LIGHT EMISSION IN SOLAR FLARES

Energy Technology Data Exchange (ETDEWEB)

Kuhar, Matej; Krucker, Säm; Battaglia, Marina; Kleint, Lucia; Casadei, Diego [University of Applied Sciences and Arts Northwestern Switzerland, Bahnhofstrasse 6, 5210 Windisch (Switzerland); Oliveros, Juan Carlos Martinez; Hudson, Hugh S. [Space Sciences Laboratory, University of California, Berkeley, CA 94720-7450 (United States)

2016-01-01

A statistical study of the correlation between hard X-ray and white light emission in solar flares is performed in order to search for a link between flare-accelerated electrons and white light formation. We analyze 43 flares spanning GOES classes M and X using observations from the Reuven Ramaty High Energy Solar Spectroscopic Imager and Helioseismic and Magnetic Imager. We calculate X-ray fluxes at 30 keV and white light fluxes at 6173 Å summed over the hard X-ray flare ribbons with an integration time of 45 s around the peak hard-X ray time. We find a good correlation between hard X-ray fluxes and excess white light fluxes, with a highest correlation coefficient of 0.68 for photons with energy of 30 keV. Assuming the thick target model, a similar correlation is found between the deposited power by flare-accelerated electrons and the white light fluxes. The correlation coefficient is found to be largest for energy deposition by electrons above ∼50 keV. At higher electron energies the correlation decreases gradually while a rapid decrease is seen if the energy provided by low-energy electrons is added. This suggests that flare-accelerated electrons of energy ∼50 keV are the main source for white light production.

Prefrontal activity during response inhibition decreases over time in the postpartum period.

Science.gov (United States)

Bannbers, Elin; Gingnell, Malin; Engman, Jonas; Morell, Arvid; Sylvén, Sara; Skalkidou, Alkistis; Kask, Kristiina; Bäckström, Torbjörn; Wikström, Johan; Poromaa, Inger Sundström

2013-03-15

The postpartum period is characterized by complex hormonal changes, but human imaging studies in the postpartum period have thus far predominantly focused on the neural correlates of maternal behavior or postpartum depression, whereas longitudinal studies on neural correlates of cognitive function across the postpartum period in healthy women are lacking. The aim of this study was to longitudinally examine response inhibition, as a measure of executive function, during the postpartum period and its neural correlates in healthy postpartum women and non-postpartum controls. Thirteen healthy postpartum women underwent event-related functional magnetic resonance imaging while performing a Go/NoGo task. The first assessment was made within 48 h of delivery, and the second at 4-7 weeks postpartum. In addition, 13 healthy women examined twice during the menstrual cycle were included as non-postpartum controls. In postpartum women region of interest analyses revealed task-related decreased activations in the right inferior frontal gyrus, right anterior cingulate, and bilateral precentral gyri at the late postpartum assessment. Generally, postpartum women displayed lower activity during response inhibition in the bilateral inferior frontal gyri and precentral gyri compared to non-postpartum controls. No differences in performance on the Go/NoGo task were found between time-points or between groups. In conclusion, this study has discovered that brain activity in prefrontal areas during a response inhibition task decreases throughout the course of the first postpartum weeks and is lower than in non-postpartum controls. Further studies on the normal adaptive brain activity changes that occur during the postpartum period are warranted. Copyright © 2012 Elsevier B.V. All rights reserved.

Long-range correlations and asymmetry in the Bitcoin market

Science.gov (United States)

Alvarez-Ramirez, J.; Rodriguez, E.; Ibarra-Valdez, C.

2018-02-01

This work studies long-range correlations and informational efficiency of the Bitcoin market for the period from June 30, 2013 to June 3rd, 2017. To this end, the detrended fluctuation analysis (DFA) was implemented over sliding windows to estimate long-range correlations for price returns. It was found that the Bitcoin market exhibits periods of efficiency alternating with periods where the price dynamics are driven by anti-persistence. The pattern is replicated by prices samples at day, hour and second frequencies. The Bitcoin market also presents asymmetric correlations with respect to increasing and decreasing price trending, with the former trend linked to anti-persistence of returns dynamics.

Ulysses Fossae in Tharsis

Science.gov (United States)

2002-01-01

[figure removed for brevity, see original site] Extensional forces in the volcanic province of Tharsis have produced a fractured terrain that resembles wrinkled skin.Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time.NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.

Correlation of fracture index with BMD T score in postmenopausal females

International Nuclear Information System (INIS)

Chaudhary, U.J.; Osman, S.S.; Moazam, S.; Shah, S.I.A.

2004-01-01

Objective: To find the correlation between fracture index and BMD T-score so that fracture index can be used as a predictive tool for fracture risk estimation in post menopausal females. Design: A cross-sectional study was conducted on a sample of 396 women age 50 years and above. BMD T-score measurements using ultrasound and fracture index calculation based on the risk factor assessment were performed. Results: The study results showed that when fracture index increases BMD T-score decreased to osteoporotic range and correlation coefficient is -0.162. Conclusion: When fracture index increases, BMD T-score decreases therefore we can use fracture index as an assessment tool for predicting fracture risk in postmenopausal females. (author)

Decreases in beetle body size linked to climate change and warming temperatures.

Science.gov (United States)

Tseng, Michelle; Kaur, Katrina M; Soleimani Pari, Sina; Sarai, Karnjit; Chan, Denessa; Yao, Christine H; Porto, Paula; Toor, Anmol; Toor, Harpawantaj S; Fograscher, Katrina

2018-05-01

Body size is a fundamental ecological trait and is correlated with population dynamics, community structure and function, and ecosystem fluxes. Laboratory data from broad taxonomic groups suggest that a widespread response to a warming world may be an overall decrease in organism body size. However, given the myriad of biotic and abiotic factors that can also influence organism body size in the wild, it is unclear whether results from these laboratory assays hold in nature. Here we use datasets spanning 30 to 100 years to examine whether the body size of wild-caught beetles has changed over time, whether body size changes are correlated with increased temperatures, and we frame these results using predictions derived from a quantitative review of laboratory responses of 22 beetle species to temperature. We found that 95% of laboratory-reared beetles decreased in size with increased rearing temperature, with larger-bodied species shrinking disproportionately more than smaller-bodied beetles. In addition, the museum datasets revealed that larger-bodied beetle species have decreased in size over time, that mean beetle body size explains much of the interspecific variation in beetle responses to temperature, and that long-term beetle size changes are explained by increases in autumn temperature and decreases in spring temperature in this region. Our data demonstrate that the relationship between body size and temperature of wild-caught beetles matches relatively well with results from laboratory studies, and that variation in this relationship is largely explained by interspecific variation in mean beetle body size. This long-term beetle dataset is one of the most comprehensive arthropod body size datasets compiled to date, it improves predictions regarding the shrinking of organisms with global climate change, and together with the meta-analysis data, call for new hypotheses to explain why larger-bodied organisms may be more sensitive to temperature. © 2018 The

Decreased tongue pressure is associated with sarcopenia and sarcopenic dysphagia in the elderly.

Science.gov (United States)

Maeda, Keisuke; Akagi, Junji

2015-02-01

The aim of this study was to clarify the association between tongue pressure and factors related to sarcopenia such as aging, activities of daily living, nutritional state, and dysphagia. One-hundred-and-four patients without a history of treatment of stroke and without a diagnosis of neurodegenerative disease (36 men and 68 women), with a mean age of 84.1 ± 5.6 years, hospitalized from May 2013 to June 2013 were included in this study. Maximum voluntary tongue pressure against the palate (MTP) was measured by a device consisting of a disposable oral balloon probe. Nutritional and anthropometric parameters such as serum albumin concentration, Mini-Nutritional Assessment short form (MNA-SF), body mass index, arm muscle area (AMA), and others and presence of sarcopenia and dysphagia were analyzed to evaluate their relationships. Correlation analysis and univariate or multivariate analysis were performed. Simple correlation analysis showed that MTP correlated with Barthel index (BI), MNA-SF, serum albumin concentration, body mass index, and AMA. Univariate and multivariate analysis showed that sarcopenia, BI, MNA-SF, and age were the independent explanatory factors for decreased MTP, and the propensity score for dysphagia, including causes of primary or secondary sarcopenia, and the presence of sarcopenia were significantly associated with the presence of dysphagia. Decreased MTP and dysphagia were related to sarcopenia or the causes of sarcopenia in the studied population. Furthermore, the clinical condition of sarcopenic dysphagia may be partially interpreted as the presence of sarcopenia and causal factors for sarcopenia.

Using a spark-spread valuation to investigate the impact of corn-gasoline correlation on ethanol plant valuation

International Nuclear Information System (INIS)

Kirby, Natasha; Davison, Matt

2010-01-01

Corn ethanol plants have been criticized for a number of reasons in recent years. This paper provides another ground for criticizing these plants. Historical corn and gasoline prices are uncorrelated, but widespread adoption of corn ethanol production might reasonably lead to future correlation between these prices. We present a real options - like valuation of an ethanol plant as a spark spread between the corn price and the gasoline price. This analysis shows that the value of an ethanol plant monotonically decreases with increasing correlation and the optimal production schedule greatly depends on the correlation. Even relatively small new correlations can result in a significant proportional value decrease; a 50% correlation between corn and gasoline causes ethanol plants to lose 10% of their value. The limiting case of full correlation would lead to a 30% value loss. (author)

Apparent diffusion coefficient correlation with oesophageal tumour stroma and angiogenesis

Energy Technology Data Exchange (ETDEWEB)

Aoyagi, Tomoyoshi; Shuto, Kiyohiko; Okazumi, Shinichi; Hayano, Kohichi; Satoh, Asami; Saitoh, Hiroshige; Shimada, Hideaki; Nabeya, Yoshihiro; Matsubara, Hisahiro [Chiba University, Department of Frontier Surgery, Graduate School of Medicine, Chiba (Japan); Kazama, Toshiki [Chiba University, Department of Radiology, Graduate School of Medicine, Chiba (Japan)

2012-06-15

Because diffusion-weighted imaging (DWI) can predict the prognosis of patients with oesophageal squamous cell carcinoma (ESCC), we hypothesised that apparent diffusion coefficient (ADC) values might be correlated with the collagen content and tumour angiogenesis. The purpose of this study was to determine the correlation between ADC values of ESCC before treatment and oesophageal tumour stroma and angiogenesis. Seventeen patients with ESCC were enrolled. The ADC values were calculated from the DWI score. Seventeen patients who had undergone oesophagectomy were analysed for tumour stroma, vascular endothelial growth factor (VEGF) and CD34. Tissue collagen was stained with azocarmine and aniline blue to quantitatively analyse the extracellular matrix in cancer stroma. Tissues were stained with VEGF and CD34 to analyse the angiogenesis. The ADC values decreased with stromal collagen growth. We found a negative correlation between the tumour ADC and the amount of stromal collagen (r = -0.729, P = 0.001), i.e. the ADC values decreased with growth of VEGF. We also found a negative correlation between the ADC of the tumours and the amount of VEGF (r = 0.538, P = 0.026). Our results indicated that the ADC value may be a novel prognostic factor and contribute to the treatment of oesophageal cancer. circle Magnetic resonance apparent diffusion coefficient values inversely indicate tumour stromal collagen circle There is also negative correlation between ADCs and vascular endothelial growth factor circle ADC values may contribute to the treatment of oesophageal cancer. (orig.)

Apparent diffusion coefficient correlation with oesophageal tumour stroma and angiogenesis

International Nuclear Information System (INIS)

Aoyagi, Tomoyoshi; Shuto, Kiyohiko; Okazumi, Shinichi; Hayano, Kohichi; Satoh, Asami; Saitoh, Hiroshige; Shimada, Hideaki; Nabeya, Yoshihiro; Matsubara, Hisahiro; Kazama, Toshiki

2012-01-01

Because diffusion-weighted imaging (DWI) can predict the prognosis of patients with oesophageal squamous cell carcinoma (ESCC), we hypothesised that apparent diffusion coefficient (ADC) values might be correlated with the collagen content and tumour angiogenesis. The purpose of this study was to determine the correlation between ADC values of ESCC before treatment and oesophageal tumour stroma and angiogenesis. Seventeen patients with ESCC were enrolled. The ADC values were calculated from the DWI score. Seventeen patients who had undergone oesophagectomy were analysed for tumour stroma, vascular endothelial growth factor (VEGF) and CD34. Tissue collagen was stained with azocarmine and aniline blue to quantitatively analyse the extracellular matrix in cancer stroma. Tissues were stained with VEGF and CD34 to analyse the angiogenesis. The ADC values decreased with stromal collagen growth. We found a negative correlation between the tumour ADC and the amount of stromal collagen (r = -0.729, P = 0.001), i.e. the ADC values decreased with growth of VEGF. We also found a negative correlation between the ADC of the tumours and the amount of VEGF (r = 0.538, P = 0.026). Our results indicated that the ADC value may be a novel prognostic factor and contribute to the treatment of oesophageal cancer. circle Magnetic resonance apparent diffusion coefficient values inversely indicate tumour stromal collagen circle There is also negative correlation between ADCs and vascular endothelial growth factor circle ADC values may contribute to the treatment of oesophageal cancer. (orig.)

Why Southern Ocean uptake of anthropogenic CO2 may be decreasing

CSIR Research Space (South Africa)

Mongwe, P

2012-10-01

Full Text Available to the warm surface water and its influence on CO2 solubility (Figures 2 and 3). The decline is DIC with depth correlates with the decrease in temperature (Figures 2 and 3), as colder water holds more CO2. The Southern Ocean has particularly high DIC... southwards, upwelling is also expected move more southwards, which may result in more intense CO2 outgassing. The emitted CO2 contributes to green house gases, which alter the heat balance and result in increased average temperatures. REFERENCES Le...

Decreased microvascular cerebral blood flow assessed by diffuse correlation spectroscopy after repetitive concussions in mice.

Science.gov (United States)

Buckley, Erin M; Miller, Benjamin F; Golinski, Julianne M; Sadeghian, Homa; McAllister, Lauren M; Vangel, Mark; Ayata, Cenk; Meehan, William P; Franceschini, Maria Angela; Whalen, Michael J

2015-12-01

Repetitive concussions are associated with long-term cognitive dysfunction that can be attenuated by increasing the time intervals between concussions; however, biomarkers of the safest rest interval between injuries remain undefined. We hypothesize that deranged cerebral blood flow (CBF) is a candidate biomarker for vulnerability to repetitive concussions. Using a mouse model of human concussion, we examined the effect of single and repetitive concussions on cognition and on an index of CBF (CBFi) measured with diffuse correlation spectroscopy. After a single mild concussion, CBFi was reduced by 35±4% at 4 hours (Pconcussions spaced 1 day apart, CBFi was also reduced from preinjury levels 4 hours after each concussion but had returned to preinjury levels by 72 hours after the final concussion. Interestingly, in this repetitive concussion model, lower CBFi values measured both preinjury and 4 hours after the third concussion were associated with worse performance on the Morris water maze assessed 72 hours after the final concussion. We conclude that low CBFi measured either before or early on in the evolution of injury caused by repetitive concussions could be a useful predictor of cognitive outcome.

Correlated binomial models and correlation structures

International Nuclear Information System (INIS)

Hisakado, Masato; Kitsukawa, Kenji; Mori, Shintaro

2006-01-01

We discuss a general method to construct correlated binomial distributions by imposing several consistent relations on the joint probability function. We obtain self-consistency relations for the conditional correlations and conditional probabilities. The beta-binomial distribution is derived by a strong symmetric assumption on the conditional correlations. Our derivation clarifies the 'correlation' structure of the beta-binomial distribution. It is also possible to study the correlation structures of other probability distributions of exchangeable (homogeneous) correlated Bernoulli random variables. We study some distribution functions and discuss their behaviours in terms of their correlation structures

Alcoholic Hepatitis Markedly Decreases the Capacity for Urea Synthesis.

Directory of Open Access Journals (Sweden)

Emilie Glavind

Full Text Available Data on quantitative metabolic liver functions in the life-threatening disease alcoholic hepatitis are scarce. Urea synthesis is an essential metabolic liver function that plays a key regulatory role in nitrogen homeostasis. The urea synthesis capacity decreases in patients with compromised liver function, whereas it increases in patients with inflammation. Alcoholic hepatitis involves both mechanisms, but how these opposite effects are balanced remains unclear. Our aim was to investigate how alcoholic hepatitis affects the capacity for urea synthesis. We related these findings to another measure of metabolic liver function, the galactose elimination capacity (GEC, as well as to clinical disease severity.We included 20 patients with alcoholic hepatitis and 7 healthy controls. The urea synthesis capacity was quantified by the functional hepatic nitrogen clearance (FHNC, i.e., the slope of the linear relationship between the blood α-amino nitrogen concentration and urea nitrogen synthesis rate during alanine infusion. The GEC was determined using blood concentration decay curves after intravenous bolus injection of galactose. Clinical disease severity was assessed by the Glasgow Alcoholic Hepatitis Score and Model for End-Stage Liver Disease (MELD score.The FHNC was markedly decreased in the alcoholic hepatitis patients compared with the healthy controls (7.2±4.9 L/h vs. 37.4±6.8 L/h, P<0.01, and the largest decrease was observed in those with severe alcoholic hepatitis (4.9±3.6 L/h vs. 9.9±4.9 L/h, P<0.05. The GEC was less markedly reduced than the FHNC. A negative correlation was detected between the FHNC and MELD score (rho = -0.49, P<0.05.Alcoholic hepatitis markedly decreases the urea synthesis capacity. This decrease is associated with an increase in clinical disease severity. Thus, the metabolic failure in alcoholic hepatitis prevails such that the liver cannot adequately perform the metabolic up-regulation observed in other stressful

Spreading of correlations in the Falicov-Kimball model

Science.gov (United States)

Herrmann, Andreas J.; Antipov, Andrey E.; Werner, Philipp

2018-04-01

We study dynamical properties of the one- and two-dimensional Falicov-Kimball model using lattice Monte Carlo simulations. In particular, we calculate the spreading of charge correlations in the equilibrium model and after an interaction quench. The results show a reduction of the light-cone velocity with interaction strength at low temperature, while the phase velocity increases. At higher temperature, the initial spreading is determined by the Fermi velocity of the noninteracting system and the maximum range of the correlations decreases with increasing interaction strength. Charge order correlations in the disorder potential enhance the range of the correlations. We also use the numerically exact lattice Monte Carlo results to benchmark the accuracy of equilibrium and nonequilibrium dynamical cluster approximation calculations. It is shown that the bias introduced by the mapping to a periodized cluster is substantial, and that from a numerical point of view, it is more efficient to simulate the lattice model directly.

Role of correlations of lattice vibrations in channeling

International Nuclear Information System (INIS)

Barrett, J.H.; Jackson, D.P.

1980-01-01

Computer simulations of channeling have been done using correlated thermal displacements of the lattice atoms. For the channeling minimum yield and half angles, results are given as a function of temperature. For the surface yield, results are given as a function of angle from the axial direction to supplement earlier results as a function of temperature. In all quantities correlations cause effects qualitatively similar to a reduction in vibration amplitude, although the reduction varies from quantity to quantity. These variations are consistent with the idea that correlations will be most important for a trajectory aligned with the rows and of decreasing importance as the direction of a trajectory approaches a random direction. The largest effect occurs for the surface yield wherein there is a reduction of about 15% for the cases studied so far. (orig.)

Correlates of Suicidal Behavior in a Juvenile Detention Population.

Science.gov (United States)

Rohde, Paul; Seeley, John R.; Mace, David E.

1997-01-01

Identifies the correlates of current suicidal ideation and past suicide attempts among 555 adolescents. Results indicate that suicidal behavior in delinquent boys was associated with depression and decreased social connection, whereas suicidal behavior in delinquent girls was associated with impulsivity and instability. Current ideation was…

Pion production and particle correlations

International Nuclear Information System (INIS)

Kristiansson, P.

1985-10-01

Intermediate energy heavy ion collisions have been studied using the carbon-beam produced at the CERN SC-accelerator. Cross-sections for π + and π - have been measured over a wide range of large angles at 60, 75 and 86 MeV/nucleon. The yields and shapes are compared to a nucleon-nucleon scattering approach, which underestimates the yields by orders of magnitude. The π - /π + -ratio observed is close to unity for 12 C + 12 C, but the enhancement for 12 C + 208 Pb is much larger than expected from the neutron excess in 208 Pb. Large-angle light-particle correlations for 86 MeV/nucleon carbon induced reactions on different targets (C, Al, Cu, Au) have been studied. An excess of correlations is observed in the particle-particle scattering plane. The strength of this effect increases with observed particle mass and decreases with target mass. (author)

GOOD HOMOSEXUAL BEHAVIOUR DECREASE PREVALENCE OF SEXUAL TRANSMITTED DISSEASE

Directory of Open Access Journals (Sweden)

Purwaningsih Purwaningsih

2017-07-01

Full Text Available Introduction: The homosexual behaviour were become indicators of sexually transmitted diseases’s (STDs prevalencies. Prevalence of sexually transmitted diseases in homosexual community was very high but until recently study it was conducted sporadically. The objective of this study was to analyze the correlation of homosexual behaviour with prevalence of sexually transmitted diseases (STDs in Mobile Clinic Community Centre of IGAMA collaborating with Public Health Centre Sumberpucung of Malang Regency. Method:  Analytic design with cross sectional methode was used in this study. The population were all visitors of Mobile Clinic Community Centre of IGAMA collaborating with Public Health Centre Sumberpucung of Malang Regency (353 people. Sample were 40 people who met to the inclusion criteria. The independent variable was homosexual behaviour and the dependent variable was prevalence of sexually transmitted diseases (STDs. Data for homosexual behaviour were collected by using questionnaire and indhept interview with content analyze and data for prevalence of sexually transmitted diseases (STDs were collected by using laboratorium test for STDs. Result: The research result was presented in the form diagram, table of cross tabulation and analyzed by using Spearman Rho with significance level ρ=0.005. The result showed that there was correlation of homosexual knowledge (ρ=0.001, attitude (ρ=0.000 and  practice (ρ=0.000 with prevalence of STDs. Dsicussion:  It can be concluded that the better knowledge, attitude and practice of homosexual could be decrease prevalence of STDs. Futher studies are recomended to analyze the correlation between homosexual behaviour and prevalence of STDs with Health Believe approach.

The Radial Variation of the Solar Wind Temperature-Speed Relationship

Science.gov (United States)

Elliott, H. A.; McComas, D. J.

2010-12-01

Generally, the solar wind temperature (T) and speed (V) are well correlated except in Interplanetary Coronal Mass Ejections where this correlation breaks down. We have shown that at 1 AU the speed-temperature relationship is often well represented by a linear fit for a speed range spanning both the slow and fast wind. By examining all of the ACE and OMNI measurements, we found that when coronal holes are large the fast wind can have a different T-V relationship than the slow wind. The best example of this was in 2003 when there was a very large and long-lived outward polarity coronal hole at low latitudes. The long-lived nature of the hole made it possible to clearly distinguish that large holes can have a different T-V relationship. We found it to be rare that holes are large enough and last long enough to have enough data points to clearly demonstrate this effect. In this study we compare the 2003 coronal hole observations from ACE with the Ulysses polar coronal hole measurements. In an even earlier ACE study we found that both the compressions and rarefactions curves are linear, but the compression curve is shifted to higher temperatures. In this presentation we use Helios, Ulysses, and ACE measurements to examine how the T-V relationship varies with distance. The dynamic evolution of the solar wind parameters is revealed when we first separate compressions and rarefactions and then determine the radial profiles of the solar wind parameters. We find that T-V relationship varies with distance and in particular beyond 3 AU the differences between the compressions and rarefactions are quite important and at such distances a simple linear fit does not represent the T-V distribution very well.

The Alpha value decrease when the annual individual effective dose decreases?

International Nuclear Information System (INIS)

Sordi, Gian M.; Marchiusi, Thiago; Sousa, Jefferson de J.

2008-01-01

A recent IAEA publication tells that a few entities took different alpha values for maxima individual doses. Beyond to disregard the international agencies, that recommend only one alpha value for each country, the alpha values decreases when the individual doses decreases and the practice happens exactly the conversely as we will show in this paper. We will prove that the alpha value increase when the maximum individual doses decreases in a four different manner. The first one we call the theoretical conception and it is linked to the emergent of the ALARA policy and to the purpose that led to the 3/10 of the annual limits, for to decrease the individual doses as a first resort and a 1/10 as a last resort. The second prove will be based in a small mine example used in the ICRP publication number 55 concerning to the optimization and the quantitative decision-aiding techniques in radiological protection where we will determine the alpha value ranges in which each radiological protection options becomes the analytical solution. The third prove will be based in the determination of the optimized thickness example of a plane shielding for a radiation source exposed in the ICRP publication number 37. We will use, also, the numerical example provided there. Eventually, as four prove we will show that the alpha value dos not only increases with the maximum individual dose decrease, but also, with the shielding geometry. (author)

Correlation ECE diagnostic in Alcator C-Mod

International Nuclear Information System (INIS)

Sung, C.; Irby, J.; Leccacorvi, R.; Vieira, R.; Oi, C.; Rice, J.; Reinke, M.; Gao, C.; Ennever, P.; Porkolab, M.; Churchill, R.; Theiler, C.; Walk, J.; Hughes, J.; Hubbard, A.; Greenwald, M.

2015-01-01

Correlation ECE (CECE) is a diagnostic technique that allows measurement of small amplitude electron temperature, Te, fluctuations through standard cross-correlation analysis methods. In Alcator C-Mod, a new CECE diagnostic has been installed[Sung RSI 2012], and interesting phenomena have been observed in various plasma conditions. We find that local Te fluctuations near the edge (ρ ~ 0:8) decrease across the linearto- saturated ohmic confinement transition, with fluctuations decreasing with increasing plasma density [Sung NF 2013], which occurs simultaneously with rotation reversals [Rice NF 2011]. Te fluctuations are also reduced across core rotation reversals with an increase of plasma density in RF heated L-mode plasmas, which implies that the same physics related to the reduction of Te fluctuations may be applied to both ohmic and RF heated L-mode plasmas. In I-mode plasmas, we observe the reduction of core Te fluctuations, which indicates changes of turbulence occur not only in the pedestal region but also in the core across the L/I transition [White NF 2014]. The present CECE diagnostic system in C-Mod and these experimental results are described in this paper

OBSERVATIONS OF THE INTERPLANETARY HYDROGEN DURING SOLAR CYCLES 23 AND 24. WHAT CAN WE DEDUCE ABOUT THE LOCAL INTERSTELLAR MEDIUM?

International Nuclear Information System (INIS)

Vincent, Frédéric E.; Quémerais, Eric; Koutroumpa, Dimitra; Katushkina, Olga; Izmodenov, Vladislav; Ben-Jaffel, Lotfi; Harris, Walter M.; Clarke, John

2014-01-01

Observations of interstellar helium atoms by the Interstellar Boundary Explorer (IBEX) spacecraft in 2009 reported a local interstellar medium (LISM) velocity vector different from the results of the Ulysses spacecraft between 1991 and 2002. The interplanetary hydrogen (IPH), a population of neutrals that fills the space between planets inside the heliosphere, carries the signatures of the LISM and its interaction with the solar wind. More than 40 yr of space-based studies of the backscattered solar Lyα emission from the IPH provided limited access to the velocity distribution, with the first temporal evolution map of the IPH line-shift during solar cycle 23. This work presents the results of the latest IPH observations made by the Hubble Space Telescope's Space Telescope Imaging Spectrograph during solar cycle 24. These results have been compiled with previous measurements, including data from the Solar Wind Anisotropies instrument on the Solar and Heliospheric Observatory. The whole set has been compared to physically realistic models to test both sets of LISM physical parameters as measured by Ulysses and IBEX, respectively. This comparison shows that the LISM velocity vector has not changed significantly since Ulysses measurements

OBSERVATIONS OF THE INTERPLANETARY HYDROGEN DURING SOLAR CYCLES 23 AND 24. WHAT CAN WE DEDUCE ABOUT THE LOCAL INTERSTELLAR MEDIUM?

Energy Technology Data Exchange (ETDEWEB)

Vincent, Frédéric E.; Quémerais, Eric; Koutroumpa, Dimitra [Université Versailles St.-Quentin, Sorbonne Universités, UPMC Univ. Paris 06, CRNS/INSU, LATMOS-IPSL, 11 boulevard d' Alembert, 78280 Guyancourt (France); Katushkina, Olga; Izmodenov, Vladislav [Space Research Institute of Russian Academy of Sciences, Moscow (Russian Federation); Ben-Jaffel, Lotfi [UPMC Univ. Paris 06, UMR7095, Institut d' Astrophysique de Paris, F-75014, Paris (France); Harris, Walter M. [University of Arizona, Lunar and Planetary Laboratory, 1629 E. University Blvd., Tucson, AZ 85721 (United States); Clarke, John [Center for Space Physics, Boston University, 725 Commonwealth Avenue, Boston, MA 02215 (United States)

2014-06-20

Observations of interstellar helium atoms by the Interstellar Boundary Explorer (IBEX) spacecraft in 2009 reported a local interstellar medium (LISM) velocity vector different from the results of the Ulysses spacecraft between 1991 and 2002. The interplanetary hydrogen (IPH), a population of neutrals that fills the space between planets inside the heliosphere, carries the signatures of the LISM and its interaction with the solar wind. More than 40 yr of space-based studies of the backscattered solar Lyα emission from the IPH provided limited access to the velocity distribution, with the first temporal evolution map of the IPH line-shift during solar cycle 23. This work presents the results of the latest IPH observations made by the Hubble Space Telescope's Space Telescope Imaging Spectrograph during solar cycle 24. These results have been compiled with previous measurements, including data from the Solar Wind Anisotropies instrument on the Solar and Heliospheric Observatory. The whole set has been compared to physically realistic models to test both sets of LISM physical parameters as measured by Ulysses and IBEX, respectively. This comparison shows that the LISM velocity vector has not changed significantly since Ulysses measurements.

Projections of increased and decreased dengue incidence under climate change.

Science.gov (United States)

Williams, C R; Mincham, G; Faddy, H; Viennet, E; Ritchie, S A; Harley, D

2016-10-01

Dengue is the world's most prevalent mosquito-borne disease, with more than 200 million people each year becoming infected. We used a mechanistic virus transmission model to determine whether climate warming would change dengue transmission in Australia. Using two climate models each with two carbon emission scenarios, we calculated future dengue epidemic potential for the period 2046-2064. Using the ECHAM5 model, decreased dengue transmission was predicted under the A2 carbon emission scenario, whereas some increases are likely under the B1 scenario. Dengue epidemic potential may decrease under climate warming due to mosquito breeding sites becoming drier and mosquito survivorship declining. These results contradict most previous studies that use correlative models to show increased dengue transmission under climate warming. Dengue epidemiology is determined by a complex interplay between climatic, human host, and pathogen factors. It is therefore naive to assume a simple relationship between climate and incidence, and incorrect to state that climate warming will uniformly increase dengue transmission, although in general the health impacts of climate change will be negative.

Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance.

Science.gov (United States)

Du, Caiqi; Zhang, Cai; Wu, Wei; Liang, Yan; Wang, Anru; Wu, Shimin; Zhao, Yue; Hou, Ling; Ning, Qin; Luo, Xiaoping

2018-04-25

A novel bioactive peptide, mitochondrial-derived peptide (MOTS-c), has recently attracted attention as a potential prevention or therapeutic option for obesity and type 2 diabetes mellitus (T2DM). MOTS-c profiles have not yet been reported in human obesity and T2DM. We aimed to determine circulating MOTS-c levels in obesity and explore the association between MOTS-c levels and various metabolic parameters. In this case-control study, 40 obese children and adolescents (27 males) and 57 controls (40 males) were recruited in the Hubei Province of China in 2017. Circulating MOTS-c levels were measured, clinical data (e.g., glucose, insulin and lipid profile) were recorded, and anthropometric measurements were performed. Finally, we investigated correlations between MOTS-c levels and related variables. MOTS-c levels were significantly decreased in the obese group compared with the control group (472.61 ± 22.83 ng/mL vs. 561.64 ± 19.19 ng/mL, p c levels were significantly decreased in obese male children and adolescents compared to their counterparts (465.26 ± 24.53 ng/mL vs. 584.07 ± 21.18 ng/mL, p 0.05). Further, MOTS-c levels were negatively correlated with body mass index (BMI), BMI standard deviation score, waist circumference, waist-to-hip ratio, fasting insulin level, HOMA-IR, and HbA1c in the male cohort. Circulating MOTS-c levels were decreased in obese male children and adolescents and correlated with markers of insulin resistance and obesity. This article is protected by copyright. All rights reserved.

From micro-correlations to macro-correlations

International Nuclear Information System (INIS)

Eliazar, Iddo

2016-01-01

Random vectors with a symmetric correlation structure share a common value of pair-wise correlation between their different components. The symmetric correlation structure appears in a multitude of settings, e.g. mixture models. In a mixture model the components of the random vector are drawn independently from a general probability distribution that is determined by an underlying parameter, and the parameter itself is randomized. In this paper we study the overall correlation of high-dimensional random vectors with a symmetric correlation structure. Considering such a random vector, and terming its pair-wise correlation “micro-correlation”, we use an asymptotic analysis to derive the random vector’s “macro-correlation” : a score that takes values in the unit interval, and that quantifies the random vector’s overall correlation. The method of obtaining macro-correlations from micro-correlations is then applied to a diverse collection of frameworks that demonstrate the method’s wide applicability.

Forward-backward rapidity correlations in a two-step scenario

International Nuclear Information System (INIS)

Brogueira, P.; Dias de Deus, J.

2007-01-01

We argue that two-step models, like String and Glasma models, with creation first of sources extended in rapidity that after locally decay into particles, lead to long range forward-backward correlations due to fluctuations in the number or the colour of the sources, and to a similar expression for the F-B correlation parameter b. In the simplest String percolation scenario, b increases with centrality or the number of participating nucleons. However, asymptotically it decreases with energy. This is different from the Glasma model where b increases with both, centrality and energy

World currency exchange rate cross-correlations

Science.gov (United States)

Droå¼dż, S.; Górski, A. Z.; Kwapień, J.

2007-08-01

World currency network constitutes one of the most complex structures that is associated with the contemporary civilization. On a way towards quantifying its characteristics we study the cross correlations in changes of the daily foreign exchange rates within the basket of 60 currencies in the period December 1998 May 2005. Such a dynamics turns out to predominantly involve one outstanding eigenvalue of the correlation matrix. The magnitude of this eigenvalue depends however crucially on which currency is used as a base currency for the remaining ones. Most prominent it looks from the perspective of a peripheral currency. This largest eigenvalue is seen to systematically decrease and thus the structure of correlations becomes more heterogeneous, when more significant currencies are used as reference. An extreme case in this later respect is the USD in the period considered. Besides providing further insight into subtle nature of complexity, these observations point to a formal procedure that in general can be used for practical purposes of measuring the relative currencies significance on various time horizons.

Hjemliggørelse og fremmedgørelse

DEFF Research Database (Denmark)

Klitgård, Ida

2013-01-01

Denne artikel er den første, der analyserer den danske digter Jørgen Sonnes hidtil forholdsvis ukendte oversættelser af passager i den irske modernistiske forfatter James Joyces Ulysses (1922). Oversættelserne udkom i det danske tidsskrift for oversat litteratur Cavalcade og sammenlignes her med de......, hvorved de fremmede og anderledes elementer netop skal bibeholdes og fremstilles som fremmede, således at læseren bliver bragt til originaltekstens univers og ikke omvendt. Disse strategier er særlig vanskelige at forholde sig til i oversættelsen af Ulysses, der præges af et såkaldt hybridt sprog, hvor...

Bloomsday 100: the making of a literary legend.

Science.gov (United States)

Kaplan, Robert M

2004-06-01

As a background to the centenary of Bloomsday, to explore the circumstances in which James Joyce wrote "Ulysses", noting the autobiographical elements and unique style, including the stream-of-consciousness technique that depicted the inner life of the characters. Selected quotations are used to illustrate these points. Joyce wanted to show that the epic and the heroic is in our lives every day. "Ulysses" defined the literary consciousness of the 20th century. By basing the novel about a day in the life of three ordinary characters on Homer's epic account of an 18 year voyage, Joyce re-established the link between 20th century consciousness and classical times.

Onset of decreased heart work is correlated with increased heart rate and shortened QT interval in high-carbohydrate fed overweight rats.

Science.gov (United States)

Durak, Aysegul; Olgar, Yusuf; Tuncay, Erkan; Karaomerlioglu, Irem; Kayki Mutlu, Gizem; Arioglu Inan, Ebru; Altan, Vecdi Melih; Turan, Belma

2017-11-01

Mechanical activity of the heart is adversely affected in metabolic syndrome (MetS) characterized by increased body mass and marked insulin resistance. Herein, we examined the effects of high carbohydrate intake on cardiac function abnormalities by evaluating in situ heart work, heart rate, and electrocardiograms (ECGs) in rats. MetS was induced in male Wistar rats by adding 32% sucrose to drinking water for 22-24 weeks and was confirmed by insulin resistance, increased body weight, increased blood glucose and serum insulin, and increased systolic and diastolic blood pressures in addition to significant loss of left ventricular integrity and increased connective tissue around myofibrils. Analysis of in situ ECG recordings showed a markedly shortened QT interval and decreased QRS amplitude with increased heart rate. We also observed increased oxidative stress and decreased antioxidant defense characterized by decreases in serum total thiol level and attenuated paraoxonase and arylesterase activities. Our data indicate that increased heart rate and a shortened QT interval concomitant with higher left ventricular developed pressure in response to β-adrenoreceptor stimulation as a result of less cyclic AMP release could be regarded as a natural compensation mechanism in overweight rats with MetS. In addition to the persistent insulin resistance and obesity associated with MetS, one should consider the decreased heart work, increased heart rate, and shortened QT interval associated with high carbohydrate intake, which may have more deleterious effects on the mammalian heart.

[Correlation analysis on normalized difference vegetation index (NDVI) of different vegetations and climatic factors in Southwest China].

Science.gov (United States)

Zhang, Yuan-Dong; Zhang, Xiao-He; Liu, Shi-Rong

2011-02-01

Based on the 1982-2006 NDVI remote sensing data and meteorological data of Southwest China, and by using GIS technology, this paper interpolated and extracted the mean annual temperature, annual precipitation, and drought index in the region, and analyzed the correlations of the annual variation of NDVI in different vegetation types (marsh, shrub, bush, grassland, meadow, coniferous forest, broad-leaved forest, alpine vegetation, and cultural vegetation) with corresponding climatic factors. In 1982-2006, the NDVI, mean annual temperature, and annual precipitation had an overall increasing trend, and the drought index decreased. Particularly, the upward trend of mean annual temperature was statistically significant. Among the nine vegetation types, the NDVI of bush and mash decreased, and the downward trend was significant for bush. The NDVI of the other seven vegetation types increased, and the upward trend was significant for coniferous forest, meadow, and alpine vegetation, and extremely significant for shrub. The mean annual temperature in the areas with all the nine vegetation types increased significantly, while the annual precipitation had no significant change. The drought index in the areas with marsh, bush, and cultural vegetation presented an increasing trend, that in the areas with meadow and alpine vegetation decreased significantly, and this index in the areas with other four vegetation types had an unobvious decreasing trend. The NDVI of shrub and coniferous forest had a significantly positive correlation with mean annual temperature, and that of shrub and meadow had significantly negative correlation with drought index. Under the conditions of the other two climatic factors unchanged, the NDVI of coniferous forest, broad-leaved forest, and alpine vegetation showed the strongest correlation with mean annual temperature, that of grass showed the strongest correlation with annual precipitation, and the NDVI of mash, shrub, grass, meadow, and cultural

Appetite - decreased

Science.gov (United States)

Loss of appetite; Decreased appetite; Anorexia ... Any illness can reduce appetite. If the illness is treatable, the appetite should return when the condition is cured. Loss of appetite can cause weight ...

The effect of noise correlations in populations of diversely tuned neurons.

Science.gov (United States)

Ecker, Alexander S; Berens, Philipp; Tolias, Andreas S; Bethge, Matthias

2011-10-05

The amount of information encoded by networks of neurons critically depends on the correlation structure of their activity. Neurons with similar stimulus preferences tend to have higher noise correlations than others. In homogeneous populations of neurons, this limited range correlation structure is highly detrimental to the accuracy of a population code. Therefore, reduced spike count correlations under attention, after adaptation, or after learning have been interpreted as evidence for a more efficient population code. Here, we analyze the role of limited range correlations in more realistic, heterogeneous population models. We use Fisher information and maximum-likelihood decoding to show that reduced correlations do not necessarily improve encoding accuracy. In fact, in populations with more than a few hundred neurons, increasing the level of limited range correlations can substantially improve encoding accuracy. We found that this improvement results from a decrease in noise entropy that is associated with increasing correlations if the marginal distributions are unchanged. Surprisingly, for constant noise entropy and in the limit of large populations, the encoding accuracy is independent of both structure and magnitude of noise correlations.

Hypoxia Decreases Invasin-Mediated Yersinia enterocolitica Internalization into Caco-2 Cells.

Science.gov (United States)

Zeitouni, Nathalie E; Dersch, Petra; Naim, Hassan Y; von Köckritz-Blickwede, Maren

2016-01-01

Yersinia enterocolitica is a major cause of human yersiniosis, with enterocolitis being a typical manifestation. These bacteria can cross the intestinal mucosa, and invade eukaryotic cells by binding to host β1 integrins, a process mediated by the bacterial effector protein invasin. This study examines the role of hypoxia on the internalization of Y. enterocolitica into intestinal epithelial cells, since the gastrointestinal tract has been shown to be physiologically deficient in oxygen levels (hypoxic), especially in cases of infection and inflammation. We show that hypoxic pre-incubation of Caco-2 cells resulted in significantly decreased bacterial internalization compared to cells grown under normoxia. This phenotype was absent after functionally blocking host β1 integrins as well as upon infection with an invasin-deficient Y. enterocolitica strain. Furthermore, downstream phosphorylation of the focal adhesion kinase was also reduced under hypoxia after infection. In good correlation to these data, cells grown under hypoxia showed decreased protein levels of β1 integrins at the apical cell surface whereas the total protein level of the hypoxia inducible factor (HIF-1) alpha was elevated. Furthermore, treatment of cells with the HIF-1 α stabilizer dimethyloxalylglycine (DMOG) also reduced invasion and decreased β1 integrin protein levels compared to control cells, indicating a potential role for HIF-1α in this process. These results suggest that hypoxia decreases invasin-integrin-mediated internalization of Y. enterocolitica into intestinal epithelial cells by reducing cell surface localization of host β1 integrins.

Decreasing Asian summer monsoon intensity after 1860 AD in the global warming epoch

Energy Technology Data Exchange (ETDEWEB)

Xu, Hai [Institute of Earth Environment, Chinese Academy of Sciences, State Key Laboratory of Loess and Quaternary Geology, Xi' an, Shaanxi Province (China); Hong, Yetang; Hong, Bin [Institute of Geochemistry, Chinese Academy of Sciences, State Key Laboratory of Environmental Geochemistry, Guiyang (China)

2012-10-15

The trend of the Indian summer monsoon (ISM) intensity and its nature during the past 100 and 200 years still remain unclear. In this study we reconstructed the ISM intensity during the past 270 years from tree ring {delta}{sup 18}O at Hongyuan, eastern edge of the Tibet Plateau. The monsoon failures inferred from {delta}{sup 18}O{sub tree} {sub ring} correlate well with those recorded in ice cores, speleothem, and historical literature sources. 22.6, 59.0, and 110.9-years frequency components in the Hongyuan {delta}{sup 18}O{sub tree} {sub ring} series, which may be the responses to solar activities, synchronize well with those recorded in other ISM indices. A notable feature of the reconstructed ISM intensity is the gradually decreasing trend from about 1860 to the present, which is inversely related to the increasing temperature trend contemporaneously. Such ''decreasing ISM intensity-increasing temperature'' tendency can also be supported by ice core records and meteorological records over a wide geographic extension. The decrease in sea surface temperature gradient between tropical and north Indian Ocean, and the decrease in land-sea thermal contrast between tropical Indian Ocean and ''Indian sub-continent-western Himalaya'' are possibly responsible for the observed decreasing ISM trend. (orig.)

Elevated lead levels from e-waste exposure are linked to decreased olfactory memory in children.

Science.gov (United States)

Zhang, Bo; Huo, Xia; Xu, Long; Cheng, Zhiheng; Cong, Xiaowei; Lu, Xueling; Xu, Xijin

2017-12-01

Lead (Pb) is a developmental neurotoxicant and can cause abnormal development of the nervous system in children. Hence, the aim of this study was to investigate the effect of Pb exposure on child olfactory memory by correlating the blood Pb levels of children in Guiyu with olfactory memory tests. We recruited 61 preschool children, 4- to 7-years of age, from Guiyu and 57 children from Haojiang. The mean blood Pb level of Guiyu children was 9.40 μg/dL, significantly higher than the 5.04 μg/dL mean blood Pb level of Haojiang children. In addition, approximately 23% of Guiyu children had blood Pb levels exceeding 10.00 μg/dL. The correlation analysis showed that blood Pb levels in children highly correlated with e-waste contact (r s  = 0.393). Moreover, the mean concentration of serum BDNF in Guiyu children (35.91 ng/ml) was higher than for Haojiang (28.10 ng/ml) and was positively correlated with blood Pb levels. Both item and source olfactory memory tests at 15 min, 5 h and 24 h after odor exposure showed that scores were lower in Guiyu children indicative of reduced olfactory memory in Guiyu children. Olfactory memory tests scores negatively correlated with blood Pb and serum BDNF levels, but were positively associated with parental education levels. At the same time, scores of both tests on children in the high blood Pb level group (blood Pb levels > 5.00 μg/dL) were lower than those in the low blood Pb level group (blood Pb levels ≤ 5.00 μg/dL), implying that Pb exposure decreases olfactory memory in children. Our findings suggest that Pb exposure in e-waste recycling and dismantling areas could result in an increase in serum BDNF level and a decrease in child olfactory memory, in addition, BDNF might be involved in olfactory memory impairment. Copyright © 2017 Elsevier Ltd. All rights reserved.

Correlation of CT perfusion and CT volumetry in patients with Alzheimers disease

International Nuclear Information System (INIS)

Czarnecka, A.; Zimny, A.; Sasiadek, M.

2010-01-01

Background: Both brain atrophy and decrease of perfusion are observed in dementive diseases. The aim of the study was to correlate the results of brain perfusion CT (pCT) and CT volumetry in patients with Alzheimers disease (AD). Material/Methods: Forty-eight patients with AD (mean age of 71.3 years) underwent brain pCT and CT volumetry. The pCT was performed at the level of basal ganglia after the injection of contrast medium (50 ml, 4 ml/sec.) with serial scanning (delay 7 sec, 50 scans, 1 scan/sec). Volumetric measurements were carried out on the basis of source images, with the use of a dedicated CT software combined with manual outlining of the regions of interest in extracerebral and intraventricular CSF spaces. Perfusion parameters of the cerebral blood flow (CBF) and cerebral blood volume (CBV) from the grey matter of frontal and temporal as well as basal ganglia were compared statistically with the volumetric measurements of frontal and temporal cortical atrophy as well as subcortical atrophy. Results: A statistically significant positive correlation was found between the values of CBF and CBV in the basal ganglia and the volumes of the lateral and third ventricles. The comparison of CBF and CBV results with the volumetric measurements in the areas of the frontal and temporal lobes showed mostly negative correlations, but none of them was of statistical significance. Conclusions: In patients with AD, the degree of cortical atrophy is not correlated with the decrease of perfusion in the grey matter and subcortical atrophy is not correlated with the decrease of perfusion in the basal ganglia region. It suggests that functional and structural changes in AD are not related to each other. (authors)

Two-particle spatial correlations in superfluid nuclei

International Nuclear Information System (INIS)

Pillet, N.; Berger, J.-F.; Sandulescu, N.; Schuck, P.

2010-01-01

We discuss the effect of pairing on two-neutron space correlations in deformed nuclei. The spatial correlations are described by the pairing tensor in coordinate space calculated in the HFB approach. Calculations are done using the D1S Gogny force. We show that the pairing tensor has a rather small extension in the relative coordinate, a feature observed earlier in spherical nuclei. It is pointed out that in deformed nuclei the coherence length corresponding to the pairing tensor has a pattern similar to what we have found previously in spherical nuclei; that is, it is maximal in the interior of the nucleus and then it decreases rather rapidly in the surface region, where it reaches a minimal value of about 2 fm. This minimal value of the coherence length in the surface is essentially determined by the finite size properties of single-particle states in the vicinity of the chemical potential and has little to do with enhanced pairing correlations in the nuclear surface. It is shown that in nuclei the coherence length is not a good indicator of the intensity of pairing correlations. This feature is contrasted with the situation in infinite matter.

Psilocybin-Induced Decrease in Amygdala Reactivity Correlates with Enhanced Positive Mood in Healthy Volunteers.

Science.gov (United States)

Kraehenmann, Rainer; Preller, Katrin H; Scheidegger, Milan; Pokorny, Thomas; Bosch, Oliver G; Seifritz, Erich; Vollenweider, Franz X

2015-10-15

The amygdala is a key structure in serotonergic emotion-processing circuits. In healthy volunteers, acute administration of the serotonin 1A/2A/2C receptor agonist psilocybin reduces neural responses to negative stimuli and induces mood changes toward positive states. However, it is little-known whether psilocybin reduces amygdala reactivity to negative stimuli and whether any change in amygdala reactivity is related to mood change. This study assessed the effects of acute administration of the hallucinogen psilocybin (.16 mg/kg) versus placebo on amygdala reactivity to negative stimuli in 25 healthy volunteers using blood oxygen level-dependent functional magnetic resonance imaging. Mood changes were assessed using the Positive and Negative Affect Schedule and the state portion of the State-Trait Anxiety Inventory. A double-blind, randomized, cross-over design was used with volunteers counterbalanced to receive psilocybin and placebo in two separate sessions at least 14 days apart. Amygdala reactivity to negative and neutral stimuli was lower after psilocybin administration than after placebo administration. The psilocybin-induced attenuation of right amygdala reactivity in response to negative stimuli was related to the psilocybin-induced increase in positive mood state. These results demonstrate that acute treatment with psilocybin decreased amygdala reactivity during emotion processing and that this was associated with an increase of positive mood in healthy volunteers. These findings may be relevant to the normalization of amygdala hyperactivity and negative mood states in patients with major depression. Copyright © 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

GC protein-derived macrophage-activating factor decreases ?-N-acetylgalactosaminidase levels in advanced cancer patients

OpenAIRE

Thyer, Lynda; Ward, Emma; Smith, Rodney; Branca, Jacopo JV; Morucci, Gabriele; Gulisano, Massimo; Noakes, David; Eslinger, Robert; Pacini, Stefania

2013-01-01

?-N-acetylgalactosaminidase (nagalase) accumulates in the serum of cancer patients and its activity correlates with tumor burden, aggressiveness and clinical disease progression. The administration of GC protein-derived macrophage-activating factor (GcMAF) to cancer patients with elevated levels of nagalase has been associated with a decrease of serum nagalase activity and with significant clinical benefits. Here, we report the results of the administration of GcMAF to a heterogeneous cohort ...

Decreased prostacyclin production in the infant of the diabetic mother

International Nuclear Information System (INIS)

Stuart, M.J.; Sunderji, S.G.; Allen, J.B.

1981-01-01

Maternal diabetes mellitus is recognized to be a predisposing factor to thrombosis in the neonate. In the adult with diabetes, abnormalities in the metabolism of AA by the platelet and vessel wall occur, which result in an increase in proaggregatory platelet thromboxane A2. A decrease in antiaggregatory vascular PGI2 has been demonstrated in the diabetic rat, although conclusive proof of a similar abnormality is lacking in humans. We evaluated vascular AA metabolism in 10 IDM (groups II and III comparison to 20 control neonates of gestational ages 32 to 40 weeks (group I). Mean uptakes of labeled AA into vascular tissue of both controls and IDM were similar. The conversion of [14C] AA to 6-keto-PGF1 alpha was not dependent on gestational age (r . 0.223) in the control neonates, with a mean value of 5.2% +- 1.3 (1 S.D.). A marked decrease (p less than 0.001) in 6-keto-PGF1 alpha formation to 1.7% +- 0.3 was found in the group II IDM of mothers with poor diabetic control (HbA1c . 9.3% +- 0.5). In the group III neonates whose mothers had normal HBA1c levels (6.1% +- 0.9), 6-keto-PGF1 alpha production was normal at 4.9% +- 0.8. Although no correlation between maternal fasting blood glucose and neonatal 6-keto-PGF1 alpha was demonstrable, a significant inverse correlation (r . 0.872; p less than 0.02) was observed between maternal HbA1c levels and the conversion of AA to 6-keto-PGF1 alpha in the vascular tissues of the IDM. It appear possible that abnormalities in platelet-vascular AA metabolism may play an etiologic role in the vascular complications present in some IDM

Correlation dimension of financial market

Science.gov (United States)

Nie, Chun-Xiao

2017-05-01

In this paper, correlation dimension is applied to financial data analysis. We calculate the correlation dimensions of some real market data and find that the dimensions are significantly smaller than those of the simulation data based on geometric Brownian motion. Based on the analysis of the Chinese and US stock market data, the main results are as follows. First, by calculating three data sets for the Chinese and US market, we find that large market volatility leads to a significant decrease in the dimensions. Second, based on 5-min stock price data, we find that the Chinese market dimension is significantly larger than the US market; this shows a significant difference between the two markets for high frequency data. Third, we randomly extract stocks from a stock set and calculate the correlation dimensions, and find that the average value of these dimensions is close to the dimension of the original set. In addition, we analyse the intuitional meaning of the relevant dimensions used in this paper, which are directly related to the average degree of the financial threshold network. The dimension measures the speed of the average degree that varies with the threshold value. A smaller dimension means that the rate of change is slower.

Invariant mass dependence of two-pion inclusive correlation functions

International Nuclear Information System (INIS)

Berger, E.L.; Singer, R.; Thomas, G.H.; Kafka, T.

1976-06-01

High energy two-particle inclusive correlations are studied as a function of the invariant mass M of the pair. Using data from 205 GeV/c pp interactions, one compares the correlation functions C(M) for (+-) and (--) pairs of produced pions. Strong positive correlations are observed in both distributions in the form of a broad threshold enhancement at small M. The decrease of C(M) as M increases is interpreted in the Mueller-Regge framework. From the M dependence of C +- one extracts an effective trajectory intercept of roughly α(0) approximately equal to 0.5 +- 0.1, consistent with the (rho,f) pair. For the exotic (--) system, one finds a low intercept, α(0) approximately equal to -0.5. A rho resonance signal is observed above background in C +- (M). Near threshold, effects suggestive of Bose symmetry are seen but are not conclusive. In an exclusive picture, one relates most of the correlation in the threshold region to resonances involving three or more pions. One also examines the joint correlations in M and the azimuthal angle phi

Keratin23 (KRT23 knockdown decreases proliferation and affects the DNA damage response of colon cancer cells.

Directory of Open Access Journals (Sweden)

Karin Birkenkamp-Demtröder

Full Text Available Keratin 23 (KRT23 is strongly expressed in colon adenocarcinomas but absent in normal colon mucosa. Array based methylation profiling of 40 colon samples showed that the promoter of KRT23 was methylated in normal colon mucosa, while hypomethylated in most adenocarcinomas. Promoter methylation correlated with absent expression, while increased KRT23 expression in tumor samples correlated with promoter hypomethylation, as confirmed by bisulfite sequencing. Demethylation induced KRT23 expression in vitro. Expression profiling of shRNA mediated stable KRT23 knockdown in colon cancer cell lines showed that KRT23 depletion affected molecules of the cell cycle and DNA replication, recombination and repair. In vitro analyses confirmed that KRT23 depletion significantly decreased the cellular proliferation of SW948 and LS1034 cells and markedly decreased the expression of genes involved in DNA damage response, mainly molecules of the double strand break repair homologous recombination pathway. KRT23 knockdown decreased the transcript and protein expression of key molecules as e.g. MRE11A, E2F1, RAD51 and BRCA1. Knockdown of KRT23 rendered colon cancer cells more sensitive to irradiation and reduced proliferation of the KRT23 depleted cells compared to irradiated control cells.

Decreased Polyunsaturated Fatty Acid Content Contributes to Increased Survival in Human Colon Cancer

Directory of Open Access Journals (Sweden)

Manuela Oraldi

2009-01-01

Full Text Available Among diet components, some fatty acids are known to affect several stages of colon carcinogenesis, whereas others are probably helpful in preventing tumors. In light of this, our aim was to determine the composition of fatty acids and the possible correlation with apoptosis in human colon carcinoma specimens at different Duke's stages and to evaluate the effect of enriching human colon cancer cell line with the possible reduced fatty acid(s. Specimens of carcinoma were compared with the corresponding non-neoplastic mucosa: a significant decrease of arachidonic acid, PPARα, Bad, and Bax and a significant increase of COX-2, Bcl-2, and pBad were found. The importance of arachidonic acid in apoptosis was demonstrated by enriching a Caco-2 cell line with this fatty acid. It induced apoptosis in a dose- and time-dependent manner via induction of PPARα that, in turn, decreased COX-2. In conclusion, the reduced content of arachidonic acid is likely related to carcinogenic process decreasing the susceptibility of cancer cells to apoptosis.

Brain regions associated with Anhedonia in healthy adults: a PET correlation study

International Nuclear Information System (INIS)

Jung, Young Chul; Chun, Ji Won; Kim, Jae Jin; Park, Hae Jeong; Lee, Jong Doo; Seok, Jeong Ho

2005-01-01

Anhedonia has been proposed to be the result of a basic neurophysiologic dysfunction and a vulnerability marker that precede and contribute to the liability of developing schizophrenia. We hypothesized that anhedonia, as a construct reflecting the decreased capacity to experience pleasure, should be associated with decreased positive hedonic affect trait. This study examined the relationship between anhedonia and positive hedonic affect trait and searched for the brain regions which correlate with anhedonia in normal subjects. Using 18 F-FDG PET scan, we investigated the brain activity of twenty one subjects during resting state. Questionnaires were administrated after the scan in order to assess the self-rated individual differences in physical/social anhedonia and positive/negative affect traits. Negative correlation between physical anhedonia score and positive affect trait score was significant (Pearson coefficient=-0.440, ρ <0.05). The subjects' physical and social anhedonia scores showed positive correlation with metabolic rates in the cerebellum and negative correlation with metabolic rates in the inferior temporal gyrus and middle frontal gyrus. In addition, the positive affect trait score positively correlated with various areas, most prominent with the inferior temporal gyrus. These results suggest that neural substrates, such as the inferior temporal gyrus and prefrontal-cerebellar circuit, which dysfunction has been proposed to be involved with the cognitive deficits of schizophrenia, may also play a significant role in the liability of affective deficits like anhedonia

Decreased Expression of Semaphorin3A/Neuropilin-1 Signaling Axis in Apical Periodontitis

Directory of Open Access Journals (Sweden)

Ying Lin

2017-01-01

Full Text Available Apical periodontitis (AP is a chronic infection of endodontic origin accompanied with bone destruction around the apical region. Semaphorin3A (Sema3A and neuropilin-1 (Nrp1 are regarded as a pair of immune regulators in bone metabolism. In this study, we firstly investigated the expression pattern of Sema3A/Nrp1 in apical periodontitis and its correlation with bone destruction. Using rat animal model, we analysed the level of mandibular bone destruction and the expression of Sema3A/Nrp1 on days 0, 7, 14, 21, 28, and 35 after pulp exposure. In addition, clinical samples from apical periodontitis patients were obtained to analyse the expression of Sema3A/Nrp1. These results indicated that the bone destruction level expanded from days 7 to 35. The number of positive cells and level of mRNA expression of Sema3A/Nrp1 were significantly decreased from days 7 to 35, with a negative correlation with bone destruction. Moreover, expression of Sema3A/Nrp1 in the AP group was reduced compared to the control group of clinical samples. In conclusion, decreased expression of Sema3A/Nrp1 was observed in periapical lesions and is potentially involved in the bone resorption of the periapical area, suggesting that Sema3A/Nrp1 may contribute to the pathological development of apical periodontitis.

Particle acceleration at corotating interaction regions in the three-dimensional heliosphere

International Nuclear Information System (INIS)

Desai, M.I.; Marsden, R.G.; Sanderson, T.R.; Balogh, A.; Forsyth, R.J.; Gosling, J.T.

1998-01-01

We have investigated the relationship between the energetic (∼1MeV) proton intensity (J) and the magnetic compression ratio (C) measured at the trailing edges of corotating interaction regions observed at Ulysses. In general, our results show that the proton intensity was well correlated with the compression ratio, provided that the seed intensity remained constant, consistent with predictions of the Fermi model. Specifically, our results indicate that particles were accelerated to above ∼1MeV in energy at or near the trailing edges of the compression regions observed in the midlatitude southern heliosphere, irrespective of whether the bounding reverse shocks were present or not. On the basis of this, we conclude that shock acceleration is probably not the only mechanism by which particles are accelerated to above ∼1MeV in energy at compression or interaction regions (CIRs). On the basis of magnetic field measurements obtained near the trailing edges of several midlatitude CIRs, we propose that particles could have been accelerated via the Fermi mechanism by being scattered back and forth across the trailing edges of the compression regions by large-amplitude Alfvacute en waves. Our results also show that the proton intensity was well correlated with the compression ratio during low solar activity periods but was essentially independent of C during periods of high solar activity. We suggest that the correlation between J and C was not observed during solar active periods because of significant variations in the seed intensity that result from sporadic contributions from transient solar events. In contrast, the correlation was observable during quiescent periods probably because contributions from transients had decreased dramatically, which allowed the CIRs to accelerate particles out of a seed population whose intensity remained relatively unperturbed. copyright 1998 American Geophysical Union

Force induced unzipping of DNA with long range correlated noise

International Nuclear Information System (INIS)

Lam, Pui-Man; Zhen, Yi

2011-01-01

We derive and solve a Fokker–Planck equation for the stationary distribution of the free energy, in a model of unzipping of double-stranded DNA under external force. The autocorrelation function of the random DNA sequence can be of a general form, including long range correlations. In the case of Ornstein–Uhlenbeck noise, characterized by a finite correlation length, our result reduces to the exact result of Allahverdyan et al, with the average number of unzipped base pairs going as (X) ∼ 1/f 2 in the white noise limit, where f is the deviation from the critical force. In the case of long range correlated noise, where the integrated autocorrelation is divergent, we find that (X) is finite at f = 0, with its value decreasing as the correlations become of longer range. This shows that long range correlations actually stabilize the DNA sequence against unzipping. Our result is also in agreement with the findings of Allahverdyan et al obtained using numerical generation of the long range correlated noise

Radiolarians decreased silicification as an evolutionary response to reduced Cenozoic ocean silica availability.

Science.gov (United States)

Lazarus, David B; Kotrc, Benjamin; Wulf, Gerwin; Schmidt, Daniela N

2009-06-09

It has been hypothesized that increased water column stratification has been an abiotic "universal driver" affecting average cell size in Cenozoic marine plankton. Gradually decreasing Cenozoic radiolarian shell weight, by contrast, suggests that competition for dissolved silica, a shared nutrient, resulted in biologic coevolution between radiolaria and marine diatoms, which expanded dramatically in the Cenozoic. We present data on the 2 components of shell weight change--size and silicification--of Cenozoic radiolarians. In low latitudes, increasing Cenozoic export of silica to deep waters by diatoms and decreasing nutrient upwelling from increased water column stratification have created modern silica-poor surface waters. Here, radiolarian silicification decreases significantly (r = 0.91, P stratification and abundance of diatoms. In high southern latitudes, Southern Ocean circulation, present since the late Eocene, maintains significant surface water silica availability. Here, radiolarian silicification decreased insignificantly (r = 0.58, P = 0.1), from approximately 0.13 at 35 Ma to 0.11 today. Trends in shell size in both time series are statistically insignificant and are not correlated with each other. We conclude that there is no universal driver changing cell size in Cenozoic marine plankton. Furthermore, biologic and physical factors have, in concert, by reducing silica availability in surface waters, forced macroevolutionary changes in Cenozoic low-latitude radiolarians.

Elite synchronized swimmers display decreased energy availability during intensified training.

Science.gov (United States)

Schaal, K; Tiollier, E; Le Meur, Y; Casazza, G; Hausswirth, C

2017-09-01

Elite synchronized swimmers follow high-volume training regimen that result in elevated rates of exercise energy expenditure (ExEE). While adequate energy intake (EI) is important to optimize recovery, a number of sport-specific constraints may lead to chronically low energy availability (EA = EI-ExEE). This study aimed to quantify changes in EA, endocrine markers of energy conservation, and perceived fatigue in synchronized swimmers, during a week of baseline training followed by 4 weeks of intensified training (IT). EI, ExEE, and body composition were measured in nine swimmers at Baseline, midpoint (IT WK 2 ), and end of IT (IT WK 4 ). Waking saliva samples were obtained to measure [leptin] s , [ghrelin] s , and [cortisol] s . Fatigue ratings were provided daily. ExEE increased by 27% during IT. Swimmers increased EI from Baseline to IT WK 2 , but decreased it significantly from IT WK 2 to IT WK 4 . EA, fat mass, and [leptin] s decreased from Baseline to IT WK 4 , while [ghrelin] s increased significantly. Fatigue at IT WK 4 was inversely correlated with Baseline EI and EA. The significant decrease in EA was accompanied by endocrine signs of energy conservation in elite swimmers. As perceived fatigue was associated with low EA, particular attention should be paid to these athletes' energy intake during phases of heavy training. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Stop signals decrease choices for palatable foods through decreased food evaluation

Science.gov (United States)

Veling, Harm; Aarts, Henk; Stroebe, Wolfgang

2013-01-01

The present study explores whether presenting specific palatable foods in close temporal proximity of stop signals in a go/no-go task decreases subsequent evaluations of such foods among participants with a relatively high appetite. Furthermore, we tested whether any decreased evaluations could mediate subsequent food choice. Participants first received a go/no-go task in which palatable foods were consistently linked to go cues or no-go cues within participants. Next, evaluation of the palatable foods was measured as well as food choice. Replicating previous work, results show that among participants with a relatively high appetite palatable foods associated with no-go cues are less often chosen as snacks compared to when these foods are associated with go cues, whereas this manipulation did not affect participants with a relatively low appetite. Moreover, this effect was completely mediated by decreased evaluation of the palatable foods that had been associated with the no-go cues, whereas evaluation of the foods associated with go cues did not mediate this effect. Results further showed that the devaluation effect of foods associated with no-go cues was independent of the amount of pairings (4 vs. 12 vs. 24) with the no-go cues. The current findings suggest that decreased food evaluation is a mechanism that explains effects of stop signals on food choice. PMID:24324451

Direct Targeting of Macrophages With Methylglyoxal-Bis-Guanylhydrazone Decreases SIV-Associated Cardiovascular Inflammation and Pathology.

Science.gov (United States)

Walker, Joshua A; Miller, Andrew D; Burdo, Tricia H; McGrath, Michael S; Williams, Kenneth C

2017-04-15

Despite effective combination antiretroviral therapy, HIV-infected individuals develop comorbidities, including cardiovascular disease, where activated macrophages play a key role. To date, few therapies target activated monocytes and macrophages. We evaluated a novel oral form of the polyamine biosynthesis inhibitor methylglyoxal-bis-guanylhydrazone (MGBG) on cardiovascular inflammation, carotid artery intima-media thickness (cIMT), and fibrosis in a simian immunodeficiency virus infection model of AIDS. Eleven simian immunodeficiency virus-infected animals received MGBG (30 mg/kg) once daily and 8 received a placebo control both beginning at 21 days postinfection (dpi). Animals were time sacrificed at 49 days post infection (dpi), when their matched placebo controls developed AIDS (63, 70, 77, 80), or at the study end-point (84 dpi). Aorta, carotid artery, and cardiac tissues were analyzed. Quantitative analyses of macrophage populations and T lymphocytes were done and correlated with cIMT and fibrosis. MGBG treatment resulted in 2.19-fold (CD163), 1.86-fold (CD68), 2.31-fold (CD206), and 2.12-fold (MAC387) decreases in macrophages in carotid arteries and significant 2.07-fold (CD163), 1.61-fold (CD68), 1.95-fold (MAC387), and 1.62-fold (CD206) decreases in macrophages in cardiac tissues. cIMT (1.49-fold) and fibrosis (2.05-fold) also were significantly decreased with MGBG treatment. Numbers of macrophage and the degree of fibrosis in treated animals were similar to uninfected animals. A positive correlation between decreased macrophage in the carotid artery and cIMT, and cardiac macrophages and fibrosis was found. These data demonstrate that directly targeting macrophages with MGBG can reduce cardiovascular inflammation, cIMT, and fibrosis. They suggest that therapies targeting macrophages with HIV could be used in conjunction with combination antiretroviral therapy.

Strong correlations in few-fermion systems

Energy Technology Data Exchange (ETDEWEB)

Bergschneider, Andrea

2017-07-26

In this thesis, I report on the deterministic preparation and the observation of strongly correlated few-fermion systems in single and double-well potentials. In a first experiment, we studied a system of one impurity interacting with a number of majority atoms which we prepared in a single potential well in the one-dimensional limit. With increasing number of majority particles, we observed a decrease in the quasi-particle residue which is in agreement with expectations from the Anderson orthogonality catastrophe. In a second experiment, we prepared two fermions in a double-well potential which represents the fundamental building block of the Fermi-Hubbard model. By increasing the repulsion between the two fermions, we observed the crossover into the antiferromagnetic Mott-insulator regime. Furthermore, I describe a new imaging technique, which allows spin-resolved single-atom detection both in in-situ and in time-of-flight. We use this technique to investigate the emergence of momentum correlations of two repulsive fermions in the ground state of the double well. With the methods developed in this thesis, we have established a framework for quantum simulation of strongly correlated many-body systems in tunable potentials.

GABA Levels Are Decreased After Stroke and GABA Changes During Rehabilitation Correlate With Motor Improvement

Science.gov (United States)

Blicher, Jakob Udby; Near, Jamie; Næss-Schmidt, Erhard; Stagg, Charlotte J.; Johansen-Berg, Heidi; Nielsen, Jørgen Feldbæk; Østergaard, Leif; Ho, Yi-Ching Lynn

2017-01-01

Background and Objective γ-Aminobutyric acid (GABA) is the dominant inhibitory neurotransmitter in the brain and is important in motor learning. We aimed to measure GABA content in primary motor cortex poststroke (using GABA-edited magnetic resonance spectroscopy [MRS]) and in relation to motor recovery during 2 weeks of constraint-induced movement therapy (CIMT). Methods Twenty-one patients (3-12 months poststroke) and 20 healthy subjects were recruited. Magnetic resonance imaging structural T1 and GABA-edited MRS were performed at baseline and after CIMT, and once in healthy subjects. GABA:creatine (GABA:Cr) ratio was measured by GABA-edited MRS. Motor function was measured using Wolf Motor Function Test (WMFT). Results Baseline comparison between stroke patients (n = 19) and healthy subjects showed a significantly lower GABA:Cr ratio in stroke patients (P GABA relative to N-acetylaspartic acid (NAA; P = .03). After 2 weeks of CIMT patients improved significantly on WMFT, but no consistent change across the group was observed for the GABA:Cr ratio (n = 17). However, the extent of improvement on WMFT correlated significantly with the magnitude of GABA:Cr changes (P GABA:Cr ratio being associated with better improvements in motor function. Conclusions In patients 3 to 12 months poststroke, GABA levels are lower in the primary motor cortex than in healthy subjects. The observed association between GABA and recovery warrants further studies on the potential use of GABA MRS as a biomarker in poststroke recovery. PMID:25055837

Decreased Nocturnal Movements in Patients with Facioscapulohumeral Muscular Dystrophy

Science.gov (United States)

Marca, Giacomo Della; Frusciante, Roberto; Dittoni, Serena; Vollono, Catello; Losurdo, Anna; Testani, Elisa; Scarano, Emanuele; Colicchio, Salvatore; Iannaccone, Elisabetta; Tonali, Pietro A.; Ricci, Enzo

2010-01-01

Study Objectives: Reduced mobility during sleep characterizes a variety of movement disorders and neuromuscular diseases. Facioscapulohumeral muscular dystrophy (FSHD) is the third most common form of muscular dystrophy in the general population, and people with FSHD have poor sleep quality. The aims of the present study were to evaluate nocturnal motor activity in patients with FSHD by means of videopolysomnography and to verify whether activity was associated with modifications in sleep structure. Methods: We enrolled 32 adult patients affected by genetically confirmed FSHD (18 women and 14 men, mean age 45.1 ± 13.4 years) and 32 matched control subjects, (18 women and 14 men, mean age 45.5 ± 11.4 years). Major body movements (MBM) were scored in videopolygraphic recordings in accordance with established criteria. An MBM index was calculated (number of MBM per hour of sleep). Results: The FSHD group showed a decrease in the MBM index (FSHD: 1.2 ± 1.1; control subjects: 2.3 ± 1.2, analysis of variance F = 13.672; p = 0.008). The sleep pattern of patients with FSHD, as compared with that of controls, was characterized by longer sleep latencies, shorter sleep durations, an increased percentage of wake during sleep, and a decreased percentage of rapid eye movement sleep. In the patient group, the MBM index was inversely correlated with severity of disease (Spearman test: r30 = −0.387; p Marca GD; Frusciante R; Dittoni S; Vollono C; Losurdo A; Testani E; Scarano E; Colicchio S; Iannaccone E; Tonali PA; Ricci E. Decreased nocturnal movements in patients with facioscapulohumeral muscular dystrophy. J Clin Sleep Med 2010;6(3):276-280. PMID:20572422

Decreased cerebral blood flow and prognosis of Alzheimer's disease. A multicenter HMPAO-SPECT study

International Nuclear Information System (INIS)

Nishimura, Tsunehiko; Hashikawa, Kazuo; Fukuyama, Hidenao

2007-01-01

The purpose of this study was to determine the usefulness of brain perfusion single photon emission computed tomography (SPECT) for evaluating the severity and progression of Alzheimer's disease (AD). Eighty-four AD patients were included. At entry, 99m Tc-HMPAO-SPECT, the Mini Mental State Examination (MMSE), Mental Function Impairment Scale (MENFIS), and the Raven Colored Progression Matrix (RCPM) were performed for all 84 patients. During the follow-up periods, two individual MMSE evaluations in 34 patients, two MENFIS evaluations in 30 patients, and two RCPM evaluations in 20 patients were performed. Based on the regions of decreased cerebral blood flow demonstrated on three-dimensional stereotactic surface projection (3D-SSP) images of SPECT, the cases were classified as type A (no decrease), type B (decreased blood flow in the parietal or temporal lobe), type C (decreased blood flow in the frontal lobe and parietal or temporal lobe), type Pc (decreased blood flow in posterior cingulate gyrus only), and ''other types''. The types of decreased blood flow, scores on neuropsychological evaluations, and symptom progression were analyzed. The MENFIS, MMSE, and RCPM scores were poorest in type C patients at entry. The degree of decrease of these scores during the follow-up periods was also greatest in type C. The greatest difference between patients with and without rapid progression in SPECT data of the mild AD patients (MMSE score≥24) was in the frontal lobe. Decreased blood flow in the frontal lobe of AD patients is correlated not only with reduced cognitive function at the time of the evaluation but with rapid progression in the subsequent clinical course. (author)

Doctors, disease and James Joyce.

Science.gov (United States)

Kaplan, Robert M

2008-08-01

The Irish author James Joyce is regarded as the greatest modernist writer of his time. His works, notably The Dead, A Portrait of the Artist as a Young Man, Ulysses and Finnegans Wake--are intensely autobiographic including meticulous descriptions of illness and states of health--no surprise in view of Joyce's medical history and hypochondria. The Dead revolves around the tragic love of a doomed tubercular youth. Ulysses has a graphic description of Mary Joyce-s death, a funeral and a birth; Stephen Dedalus, the character based on Joyce, attends a drinking session with medical students at the lying-in hospital just as Joyce had done as a student; references to syphilis, alcoholism and other illnesses abound.

26-Day Variations of 7 MeV Electrons at high Latitudes and their Implications on the Heliospheric Magnetic Field

Science.gov (United States)

Sternal, Oliver; Engelbrecht, Eugene; Burger, Renier; Dunzlaff, Phillip; Ferreira, Stefan; Fichtner, Horst; Heber, Bernd; Kopp, Andreas; Potgieter, Marius; Scherer, Klaus

The transport of energetic particles in the heliosphere is usually described by the Parker trans-port equation including the physical processes of diffusion, drift, convection and adiabatic energy changes. The Ulysses spacecraft provides unique insight into the flux of MeV electrons at high latitudes. In this contribution, we compare our model results for the Parker HMF model and the Fisk-type Schwadron-Parker HMF model to Ulysses measurements. The elec-tron flux at high latitudes has been used as a remote sensing method to investigate the imprint of a Fisk-type HMF. We show here for the first time that such an imprint exists and deduce a limitation on the Fisk HMF angle β.

Decreasing Relative Risk Premium

DEFF Research Database (Denmark)

Hansen, Frank

relative risk premium in the small implies decreasing relative risk premium in the large, and decreasing relative risk premium everywhere implies risk aversion. We finally show that preferences with decreasing relative risk premium may be equivalently expressed in terms of certain preferences on risky......We consider the risk premium demanded by a decision maker with wealth x in order to be indifferent between obtaining a new level of wealth y1 with certainty, or to participate in a lottery which either results in unchanged present wealth or a level of wealth y2 > y1. We define the relative risk...... premium as the quotient between the risk premium and the increase in wealth y1–x which the decision maker puts on the line by choosing the lottery in place of receiving y1 with certainty. We study preferences such that the relative risk premium is a decreasing function of present wealth, and we determine...

Depressed patients have decreased binding of tritiated imipramine to platelet serotonin ''transporter''

International Nuclear Information System (INIS)

Paul, S.M.; Rehavi, M.; Skolnick, P.; Ballenger, J.C.; Goodwin, F.K.

1981-01-01

The high-affinity tritiated (3H) imipramine binding sites are functionally (and perhaps structurally) associated with the presynaptic neuronal and platelet uptake sites for serotonin. Since there is an excellent correlation between the relative potencies of a series of antidepressants in displacing 3H-imipramine from binding sites in human brain and platelet, we have examined the binding of 3H-imipramine to platelets from 14 depressed patients and 28 age- and sex-matched controls. A highly significant decrease in the number of 3H-imipramine binding sites, with no significant change in the apparent affinity constants, was observed in platelets from the depressed patients compared with the controls. These results, coupled with previous studies showing a significant decrease in the maximal uptake of serotonin in platelets from depressed patients, suggest that an inherited or acquired deficiency of the serotonin transport protein or proteins may be involved in the pathogenesis of depression

Experimental Warming Decreases the Average Size and Nucleic Acid Content of Marine Bacterial Communities

KAUST Repository

Huete-Stauffer, Tamara M.

2016-05-23

Organism size reduction with increasing temperature has been suggested as a universal response to global warming. Since genome size is usually correlated to cell size, reduction of genome size in unicells could be a parallel outcome of warming at ecological and evolutionary time scales. In this study, the short-term response of cell size and nucleic acid content of coastal marine prokaryotic communities to temperature was studied over a full annual cycle at a NE Atlantic temperate site. We used flow cytometry and experimental warming incubations, spanning a 6°C range, to analyze the hypothesized reduction with temperature in the size of the widespread flow cytometric bacterial groups of high and low nucleic acid content (HNA and LNA bacteria, respectively). Our results showed decreases in size in response to experimental warming, which were more marked in 0.8 μm pre-filtered treatment rather than in the whole community treatment, thus excluding the role of protistan grazers in our findings. Interestingly, a significant effect of temperature on reducing the average nucleic acid content (NAC) of prokaryotic cells in the communities was also observed. Cell size and nucleic acid decrease with temperature were correlated, showing a common mean decrease of 0.4% per °C. The usually larger HNA bacteria consistently showed a greater reduction in cell and NAC compared with their LNA counterparts, especially during the spring phytoplankton bloom period associated to maximum bacterial growth rates in response to nutrient availability. Our results show that the already smallest planktonic microbes, yet with key roles in global biogeochemical cycling, are likely undergoing important structural shrinkage in response to rising temperatures.

Experimental Warming Decreases the Average Size and Nucleic Acid Content of Marine Bacterial Communities

KAUST Repository

Huete-Stauffer, Tamara M.; Arandia-Gorostidi, Nestor; Alonso-Sá ez, Laura; Moran, Xose Anxelu G.

2016-01-01

Organism size reduction with increasing temperature has been suggested as a universal response to global warming. Since genome size is usually correlated to cell size, reduction of genome size in unicells could be a parallel outcome of warming at ecological and evolutionary time scales. In this study, the short-term response of cell size and nucleic acid content of coastal marine prokaryotic communities to temperature was studied over a full annual cycle at a NE Atlantic temperate site. We used flow cytometry and experimental warming incubations, spanning a 6°C range, to analyze the hypothesized reduction with temperature in the size of the widespread flow cytometric bacterial groups of high and low nucleic acid content (HNA and LNA bacteria, respectively). Our results showed decreases in size in response to experimental warming, which were more marked in 0.8 μm pre-filtered treatment rather than in the whole community treatment, thus excluding the role of protistan grazers in our findings. Interestingly, a significant effect of temperature on reducing the average nucleic acid content (NAC) of prokaryotic cells in the communities was also observed. Cell size and nucleic acid decrease with temperature were correlated, showing a common mean decrease of 0.4% per °C. The usually larger HNA bacteria consistently showed a greater reduction in cell and NAC compared with their LNA counterparts, especially during the spring phytoplankton bloom period associated to maximum bacterial growth rates in response to nutrient availability. Our results show that the already smallest planktonic microbes, yet with key roles in global biogeochemical cycling, are likely undergoing important structural shrinkage in response to rising temperatures.

Elliptocytes and tailed poikilocytes correlate with severity of iron-deficiency anemia.

Science.gov (United States)

Rodgers, M S; Chang, C C; Kass, L

1999-05-01

This study examines the relationships between abnormal RBC morphology, RBC indices measured with an automated hematology analyzer, serum iron studies, and severity of anemia in patients with findings indicative of iron-deficiency anemia. Counts and morphologic classification of 1,000 RBCs from each of 22 patients were performed, and correlations were determined between parameters. The Student t test was used to determine the level of significance for correlations between parameters. Several significant relationships were found. As the percentage of elliptocytes increased, hemoglobin concentration, hematocrit, RBC concentration, and mean corpuscular hemoglobin level decreased (r = .48, .44, .40, and .49, respectively; P < .05). As the percentage of tailed poikilocytes increased, hemoglobin concentration, hematocrit, and RBC concentration decreased (r = .70, .77, and .71, respectively; P < .01) and RBC distribution width increased (r = .73; P < .01). Of significance, serum ferritin levels, long considered the best single indicator of iron deficiency, showed no correlation with the morphologic abnormalities assessed, severity of anemia, or any of the analyzer-generated indices. Our results indicate that microscopic evaluation of RBC morphology remains an important tool for the pathologist to evaluate the severity of anemia in patients with iron deficiency.

Decreased expression of fibulin-4 in aortic wall of aortic dissection.

Science.gov (United States)

Huawei, P; Qian, C; Chuan, T; Lei, L; Laing, W; Wenlong, X; Wenzhi, L

2014-02-01

In this research, we will examine the expression of Fibulin-4 in aortic wall to find out its role in aortic dissection development. The samples of aortic wall were obtained from 10 patients operated for acute ascending aortic dissection and five patients for chronic ascending aortic dissection. Another 15 pieces of samples from patients who had coronary artery bypass were as controls. The aortic samples were stained with aldehyde magenta dyeing to evaluate the arrangement of elastic fibers. The Fibulin-4 protein and mRNA expression were both determined by Western blot and realtime quantitative polymerase chain reaction. Compared with the control group, both in acute and chronic ascending aortic dissection, elastic fiber fragments increased and the expression of fibulin-4 protein significantly decreased (P= 0.045 < 0.05). The level of fibulin-4 mRNA decreased in acute ascending aortic dissection (P= 0.034 < 0.05), while it increased in chronic ascending aortic dissection (P=0.004 < 0.05). The increased amounts of elastic fiber fragments were negatively correlated with the expression of fibulin-4 mRNA in acute ascending aortic dissection. In conclusion, in aortic wall of ascending aortic dissection, the expression of fibulin-4 protein decreased and the expression of fibulin-4 mRNA was abnormal. Fibulin-4 may play an important role in the pathogenesis of aortic dissection.

Detecting Near-Earth Objects Using Cross-Correlation with a Point Spread Function

Science.gov (United States)

2009-03-01

impact in the Yucatan Peninsula caused the extinction of the dinosaurs in the Cretaceous Period [Fix, 1995]. Even the Moon is pot marked by many...the atmosphere that the light traverses. For this reason , it is typically better to be at higher elevations to decrease the amount of atmosphere the...detection on average for the Rayleigh sampling with cross-correlation of a PSF than the Rayleigh sampling without cross- correlation. For this reason

Airplane radiation dose decrease during a strong Forbush decrease

Czech Academy of Sciences Publication Activity Database

Spurný, František; Kudela, K.; Dachev, T.

2004-01-01

Roč. 2, S05001 (2004), s. 1-4 ISSN 1542-7390 Grant - others:EC project(XE) FIGM-CT2000-00068 Institutional research plan: CEZ:AV0Z1048901 Keywords : airplane dose * Forbush decrease * cosmic rays Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders

Brain regions associated with Anhedonia in healthy adults: a PET correlation study

Energy Technology Data Exchange (ETDEWEB)

Jung, Young Chul; Chun, Ji Won; Kim, Jae Jin; Park, Hae Jeong; Lee, Jong Doo [Yonsei University College of Medicine, Gwangju (Korea, Republic of); Seok, Jeong Ho [Hallym University Sacred Heart Hospital, Anyang (Korea, Republic of)

2005-10-15

Anhedonia has been proposed to be the result of a basic neurophysiologic dysfunction and a vulnerability marker that precede and contribute to the liability of developing schizophrenia. We hypothesized that anhedonia, as a construct reflecting the decreased capacity to experience pleasure, should be associated with decreased positive hedonic affect trait. This study examined the relationship between anhedonia and positive hedonic affect trait and searched for the brain regions which correlate with anhedonia in normal subjects. Using {sup 18}F-FDG PET scan, we investigated the brain activity of twenty one subjects during resting state. Questionnaires were administrated after the scan in order to assess the self-rated individual differences in physical/social anhedonia and positive/negative affect traits. Negative correlation between physical anhedonia score and positive affect trait score was significant (Pearson coefficient=-0.440, {rho} <0.05). The subjects' physical and social anhedonia scores showed positive correlation with metabolic rates in the cerebellum and negative correlation with metabolic rates in the inferior temporal gyrus and middle frontal gyrus. In addition, the positive affect trait score positively correlated with various areas, most prominent with the inferior temporal gyrus. These results suggest that neural substrates, such as the inferior temporal gyrus and prefrontal-cerebellar circuit, which dysfunction has been proposed to be involved with the cognitive deficits of schizophrenia, may also play a significant role in the liability of affective deficits like anhedonia.

Hiking strap force decreases during sustained upwind sailing

DEFF Research Database (Denmark)

Buchardt, R; Bay, Jonathan; Bojsen-Møller, Jens

2017-01-01

The hypothesis, that sailing upwind in wind speeds above 12 knots causes fatigue, which manifests as a reduction in exerted hiking strap force and/or maximal isometric voluntary contraction force (MVC) of the knee extensors, was evaluated. Additionally, it was investigated if a relationship exists...... between maximal exerted hiking force (hMVC) and sailing performance. In part 1 of the study, 12 national level athletes sailed upwind for 2 × 10 min while hiking strap forces were continuously acquired. Before, in between and after sailing periods, the MVC of the knee extensors was measured. In part 2...... of the study, hMVC was measured dry land in a hiking bench and correlated with the overall results at a national championship. Hiking strap force decreased from the first to the last minute in both 10 min sailing periods (430 ± 131 vs. 285 ± 130 N, P 

Decreased Self-Concept Clarity in People with Schizophrenia

Science.gov (United States)

Cicero, David C.; Martin, Elizabeth A; Becker, Theresa M.; Kerns, John G.

2015-01-01

Disturbances in the perception of self are thought to be central to the development of psychosis. Self-concept clarity (SCC) is the extent to which one’s beliefs about oneself are internally consistent, stable, and clear. Participants with schizophrenia (N = 54) and healthy controls (N = 32) completed the Me Not-Me Decision Task (MNMDT), in which they decided whether 60 adjectives (30 pairs of antonyms), did or did not describe themselves. SCC is conceptualized as the number of consistent responses. Participants also completed the Self-Concept Clarity Scale (SCCS). Compared to healthy controls, participants with schizophrenia scored lower on the MNMDT and SCCS, and scores were negatively correlated with positive and negative symptoms. In a simultaneous regression, SCCS scores were uniquely associated with positive symptoms, while MNMDT scores were uniquely associated with negative symptoms. This suggests that people with schizophrenia have decreased self-concept claritythat is related to positive and negative symptoms. PMID:26669980

Increased radial glia quiescence, decreased reactivation upon injury and unaltered neuroblast behavior underlie decreased neurogenesis in the aging zebrafish telencephalon.

Science.gov (United States)

Edelmann, Kathrin; Glashauser, Lena; Sprungala, Susanne; Hesl, Birgit; Fritschle, Maike; Ninkovic, Jovica; Godinho, Leanne; Chapouton, Prisca

2013-09-01

The zebrafish has recently become a source of new data on the mechanisms of neural stem cell (NSC) maintenance and ongoing neurogenesis in adult brains. In this vertebrate, neurogenesis occurs at high levels in all ventricular regions of the brain, and brain injuries recover successfully, owing to the recruitment of radial glia, which function as NSCs. This new vertebrate model of adult neurogenesis is thus advancing our knowledge of the molecular cues in use for the activation of NSCs and fate of their progeny. Because the regenerative potential of somatic stem cells generally weakens with increasing age, it is important to assess the extent to which zebrafish NSC potential decreases or remains unaltered with age. We found that neurogenesis in the ventricular zone, in the olfactory bulb, and in a newly identified parenchymal zone of the telencephalon indeed declines as the fish ages and that oligodendrogenesis also declines. In the ventricular zone, the radial glial cell population remains largely unaltered morphologically but enters less frequently into the cell cycle and hence produces fewer neuroblasts. The neuroblasts themselves do not change their behavior with age and produce the same number of postmitotic neurons. Thus, decreased neurogenesis in the physiologically aging zebrafish brain is correlated with an increasing quiescence of radial glia. After injuries, radial glia in aged brains are reactivated, and the percentage of cell cycle entry is increased in the radial glia population. However, this reaction is far less pronounced than in younger animals, pointing to irreversible changes in aging zebrafish radial glia. Copyright © 2013 Wiley Periodicals, Inc.

Decreasing burned children's pain behavior: impacting the trauma of hydrotherapy.

Science.gov (United States)

Kelley, M L; Jarvie, G J; Middlebrook, J L; McNeer, M F; Drabman, R S

1984-01-01

We evaluated the effects of cartoon viewing with the use of a star feedback chart on two burned children's pain behavior during their physical therapy sessions. In addition, the degree to which the observational data corresponded with physical therapists' and mothers' ratings of the children's pain, fear, and cooperativeness was examined. Using a reversal single-subject design, the results showed that the children's pain behavior substantially decreased during experimental treatment sessions compared to their baseline levels. The rating scale data indicated that the physical therapist's and mother's rating of pain, anxiety, and cooperativeness were all correlated significantly with the observational data (p less than .05). The contributions of respondent and operant conditioning to the occurrence and treatment of pain behavior in burned children are discussed. PMID:6735948

Wolfram syndrome: a clinicopathologic correlation.

Science.gov (United States)

Hilson, Justin B; Merchant, Saumil N; Adams, Joe C; Joseph, Jeffrey T

2009-09-01

Wolfram syndrome or DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy and deafness) is a neurodegenerative disorder characterized by diabetes mellitus and optic atrophy as well as diabetes insipidus and deafness in many cases. We report the post-mortem neuropathologic findings of a patient with Wolfram syndrome and correlate them with his clinical presentation. In the hypothalamus, neurons in the paraventricular and supraoptic nuclei were markedly decreased and minimal neurohypophyseal tissue remained in the pituitary. The pontine base and inferior olivary nucleus showed gross shrinkage and neuron loss, while the cerebellum was relatively unaffected. The visual system had moderate to marked loss of retinal ganglion neurons, commensurate loss of myelinated axons in the optic nerve, chiasm and tract, and neuron loss in the lateral geniculate nucleus but preservation of the primary visual cortex. The patient's inner ear showed loss of the organ of Corti in the basal turn of the cochleae and mild focal atrophy of the stria vascularis. These findings correlated well with the patient's high-frequency hearing loss. The pathologic findings correlated closely with the patient's clinical symptoms and further support the concept of Wolfram syndrome as a neurodegenerative disorder. Our findings extend prior neuropathologic reports of Wolfram syndrome by providing contributions to our understanding of eye, inner ear and olivopontine pathology in this disease.

Global study of quadrupole correlation effects

International Nuclear Information System (INIS)

Bender, M.; Bertsch, G.F.; Heenen, P.-H.

2006-01-01

We discuss the systematics of ground-state quadrupole correlations of binding energies and mean-square charge radii for all even-even nuclei, from 16 O up to the superheavies, for which data are available. To that aim we calculate their correlated J=0 ground state by means of the angular-momentum and particle-number projected generator coordinate method, using the axial mass quadrupole moment as the generator coordinate and self-consistent mean-field states restricted only by axial, parity, and time-reversal symmetries. The calculation is performed within the framework of a nonrelativistic self-consistent mean-field model by use of the same Skyrme interaction SLy4 and to a density-dependent pairing force to generate the mean-field configurations and to mix them. These are the main conclusions of our study: (i) The quadrupole correlation energy varies between a few 100 keV and about 5.5 MeV. It is affected by shell closures, but varies only slightly with mass and asymmetry. (ii) Projection on angular momentum J=0 provides the major part of the energy gain of up to about 4 MeV; all nuclei in the study, including doubly magic ones, gain energy by deformation. (iii) The mixing of projected states with different intrinsic axial deformations adds a few 100 keV up to 1.5 MeV to the correlation energy. (iv) Typically nuclei below mass A≤60 have a larger correlation energy than static deformation energy whereas the heavier deformed nuclei have larger static deformation energy than correlation energy. (v) Inclusion of the quadrupole correlation energy improves the description of mass systematics, particularly around shell closures, and of differential quantities, namely two-nucleon separation energies and two-nucleon gaps. The correlation energy provides an explanation of 'mutually enhanced magicity'. (vi) The correlation energy tends to decrease the shell effect on binding energies around magic numbers, but the magnitude of the suppression is not large enough to explain

Radiation-induced parotid gland changes in oral cancer patients. Correlation between parotid volume and saliva production

International Nuclear Information System (INIS)

Teshima, Keiko; Murakami, Ryuji; Tomitaka, Etsuji

2010-01-01

The objective of this study was to evaluate whether saliva production reflects the parotid volume during the course of radiation therapy (RT) in patients with head-and-neck cancer. Twenty patients with advanced oral squamous cell carcinomas, who were treated with preoperative chemo-RT, underwent morphological assessment with CT or MRI and functional assessment with the Saxon test. For the Saxon test, saliva production was measured by weighing a gauze pad before and 2 min after chewing without swallowing; the low-normal value is 2 g. Saliva production and parotid volumes before and 2 weeks after RT were compared with the paired t-test, the Spearman rank correlation test and the Fisher exact test. After 30 Gy irradiation, mean saliva production was decreased from 4.2 to 1.0 g (P 3 (P<0.01); the post-RT: pre-RT parotid volume ratio ranged from 54% to 85% (mean 71%). Although the initial parotid volume was correlated with initial saliva production (r=0.47, P=0.04), no significant correlation was noted after RT (r=0.08, P=0.71), and there were considerable individual variations. The parotid volume ratio was inversely correlated with the saliva-reduction amount (r=-0.79, P<0.01). There was a correlation between decreased parotid gland volume and decreased saliva production in patients with head-and-neck cancer undergoing RT. Parotid volume reduction may predict parotid gland function. (author)

Exceptional points and quantum correlations in precise measurements

International Nuclear Information System (INIS)

Thilagam, A

2012-01-01

We examine the physical manifestations of exceptional points and passage times in a two-level system which is subjected to quantum measurements and which admits a non-Hermitian description. Using an effective Hamiltonian acting in the two-dimensional space spanned by the evolving initial and final states, the effects of highly precise quantum measurements in which the monitoring device interferes significantly with the evolution dynamics of the monitored two-level system is analyzed. The dynamics of a multipartite system consisting of the two-level system, a source of external potential and the measurement device is examined using correlation measures such as entanglement and non-classical quantum correlations. Results show that the quantum correlations between the monitored (monitoring) systems is considerably decreased (increased) as the measurement precision nears the exceptional point, at which the passage time is half of the measurement duration. The results indicate that the underlying mechanism by which the non-classical correlations of quantum systems are transferred from one subsystem to another may be better revealed via use of geometric approaches. This article is part of a special issue of Journal of Physics A: Mathematical and Theoretical devoted to ‘Quantum physics with non-Hermitian operators’. (paper)

Correlation of Serum Ascorbic Acid with Serum Lipids in Healthy Subjects

OpenAIRE

藤野, 武彦; 村田, 晃; 金谷, 庄蔵; 森田, ケイ; 宇都宮, 弘子; 本多, 理恵

1985-01-01

The serum levels of ascorbic acid (ASA), total cholesterol, HDL cholesterol and triglyceride were estimated in 82 healthy persons who consisted of 41 men aged 18 to 69 and 41 women aged 32 to 69. None of fasting lipid profils correlated with the serum level of ASA in total subjects. In young men aged 18 to 23, however, there was significant negative correlation between ASA and total cholesterol. These findings suggest that ASA may be one of effective drug to decrease the level of cholesterol.

Neural correlates of the LSD experience revealed by multimodal neuroimaging.

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Carhart-Harris, Robin L; Muthukumaraswamy, Suresh; Roseman, Leor; Kaelen, Mendel; Droog, Wouter; Murphy, Kevin; Tagliazucchi, Enzo; Schenberg, Eduardo E; Nest, Timothy; Orban, Csaba; Leech, Robert; Williams, Luke T; Williams, Tim M; Bolstridge, Mark; Sessa, Ben; McGonigle, John; Sereno, Martin I; Nichols, David; Hellyer, Peter J; Hobden, Peter; Evans, John; Singh, Krish D; Wise, Richard G; Curran, H Valerie; Feilding, Amanda; Nutt, David J

2016-04-26

Lysergic acid diethylamide (LSD) is the prototypical psychedelic drug, but its effects on the human brain have never been studied before with modern neuroimaging. Here, three complementary neuroimaging techniques: arterial spin labeling (ASL), blood oxygen level-dependent (BOLD) measures, and magnetoencephalography (MEG), implemented during resting state conditions, revealed marked changes in brain activity after LSD that correlated strongly with its characteristic psychological effects. Increased visual cortex cerebral blood flow (CBF), decreased visual cortex alpha power, and a greatly expanded primary visual cortex (V1) functional connectivity profile correlated strongly with ratings of visual hallucinations, implying that intrinsic brain activity exerts greater influence on visual processing in the psychedelic state, thereby defining its hallucinatory quality. LSD's marked effects on the visual cortex did not significantly correlate with the drug's other characteristic effects on consciousness, however. Rather, decreased connectivity between the parahippocampus and retrosplenial cortex (RSC) correlated strongly with ratings of "ego-dissolution" and "altered meaning," implying the importance of this particular circuit for the maintenance of "self" or "ego" and its processing of "meaning." Strong relationships were also found between the different imaging metrics, enabling firmer inferences to be made about their functional significance. This uniquely comprehensive examination of the LSD state represents an important advance in scientific research with psychedelic drugs at a time of growing interest in their scientific and therapeutic value. The present results contribute important new insights into the characteristic hallucinatory and consciousness-altering properties of psychedelics that inform on how they can model certain pathological states and potentially treat others.

Decreasing trend in severe weather occurrence over China during the past 50 years

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Zhang, Qinghong; Ni, Xiang; Zhang, Fuqing

2017-04-01

Understanding the trend of localized severe weather under the changing climate is of great significance but remains challenging which is at least partially due to the lack of persistent and homogeneous severe weather observations at climate scales while the detailed physical processes of severe weather cannot be resolved in global climate models. Based on continuous and coherent severe weather reports from over 500 manned stations, for the first time, this study shows a significant decreasing trend in severe weather occurrence across China during the past five decades. The total number of severe weather days that have either thunderstorm, hail and/or damaging wind decrease about 50% from 1961 to 2010. It is further shown that the reduction in severe weather occurrences correlates strongly with the weakening of East Asian summer monsoon which is the primary source of moisture and dynamic forcing conducive for warm-season severe weather over China.

HYDROXYUREA TREATMENT DECREASES GLOMERULAR HYPERFILTRATION IN CHILDREN WITH SICKLE CELL ANEMIA

Science.gov (United States)

Aygun, Banu; Mortier, Nicole A.; Smeltzer, Matthew P.; Shulkin, Barry L.; Hankins, Jane S.; Ware, Russell E.

2015-01-01

Background Glomerular hyperfiltration and microalbuminuria/proteinuria are early manifestations of sickle nephropathy. The effects of hydroxyurea therapy on these renal manifestations of sickle cell anemia (SCA) are not well defined. Objective To investigate the effects of hydroxyurea on glomerular filtration rate (GFR) measured by 99mTc-DTPA clearance, and on microalbuminuria/proteinuria in children with SCA. Study Design Hydroxyurea Study of Long-Term Effects (HUSTLE) is a prospective study (NCT00305175) with the goal of describing the long-term cellular, molecular, and clinical effects of hydroxyurea therapy in SCA. Glomerular filtration rate, urine microalbumin, and serum cystatin C were measured before initiating hydroxyurea therapy and then repeated after 3 years. Baseline and Year 3 values for HUSTLE subjects were compared using the Wilcoxon Signed Rank test. Associations between continuous variables were evaluated using Spearman correlation coefficient. Results Twenty-three children with SCA (median age 7.5 years, range 2.5–14.0 years) received hydroxyurea at maximum tolerated dose (MTD, 24.4 ± 4.5 mg/kg/day, range 15.3–30.6 mg/kg/day). After three years of treatment, GFR measured by 99mTc-DTPA decreased significantly from 167 ± 46 mL/min/1.73m2 to 145 ± 27 mL/min/1.73m2 (p=0.016). This decrease in GFR was significantly associated with increase in fetal hemoglobin (p= 0.042) and decrease in lactate dehydrogenase levels (p=0.035). Urine microalbumin and cystatin C levels did not change significantly. Conclusions Hydroxyurea at MTD is associated with a decrease in hyperfiltration in young children with SCA. PMID:23255310

Decreased Circulating mtDNA Levels in Professional Male Volleyball Players.

Science.gov (United States)

Nasi, Milena; Cristani, Alessandro; Pinti, Marcello; Lamberti, Igor; Gibellini, Lara; De Biasi, Sara; Guazzaloca, Alessandro; Trenti, Tommaso; Cossarizza, Andrea

2016-01-01

Exercise exerts various effects on the immune system, and evidence is emerging on its anti-inflammatory effects; the mechanisms on the basis of these modifications are poorly understood. Mitochondrial DNA (mtDNA) released from damaged cells acts as a molecule containing the so-called damage-associated molecular patterns and can trigger sterile inflammation. Indeed, high plasma levels of mtDNA are associated to several inflammatory conditions and physiological aging and longevity. The authors evaluated plasma mtDNA in professional male volleyball players during seasonal training and the possible correlation between mtDNA levels and clinical parameters, body composition, and physical performance. Plasma mtDNA was quantified by real-time PCR every 2 mo in 12 professional volleyball players (PVPs) during 2 consecutive seasons. As comparison, 20 healthy nonathlete male volunteers (NAs) were analyzed. The authors found lower levels of mtDNA in plasma of PVPs than in NAs. However, PVPs showed a decrease of circulating mtDNA only in the first season, while no appreciable variations were observed during the second season. No correlation was observed among mtDNA, hematochemical, and anthropometric parameters. Regular physical activity appeared associated with lower levels of circulating mtDNA, further confirming the protective, anti-inflammatory effect of exercise.

ANALYSING THE LEVEL OF CORRELATION AMONG TURKEY AND EUROPEAN UNION MARKETS

Directory of Open Access Journals (Sweden)

HAKAN SARITAŞ

2013-06-01

Full Text Available International portfolio investments are growing rapidly as a result of the relaxation of capital controls in national markets. The most attractive aspect of international portfolio investments for investors is that investors are able to decrease the volatility of their investments through diversification. Although international portfolio investments provide tremendous diversification benefits, the level of correlation among the equity markets around the world has an important impact on diversification. If cross-country correlations are small, international diversification can provide investors with an attractive risk-return profile. However, investors may not be able to diversify away much domestic risk if the cross-country correlations are large. In this study, I analyzed the correlation between the Turkish equity market and equity markets of European Union (EU countries. The aim was to figure out the effects of developments emerged in the way of Turkey’s membership to EU on the level of correlation between the Turkish equity market and EU markets. The findings of the study indicate that mentioned developments increased the level of correlation between the Turkish equity market and EU markets.

Analysis of radiological parameters associated with decreased fractional anisotropy values on diffusion tensor imaging in patients with lumbar spinal stenosis.

Science.gov (United States)

Wang, Xiandi; Wang, Hongli; Sun, Chi; Zhou, Shuyi; Meng, Tao; Lv, Feizhou; Ma, Xiaosheng; Xia, Xinlei; Jiang, Jianyuan

2018-04-26

Previous studies have indicated that decreased fractional anisotropy (FA) values on diffusion tensor imaging (DTI) are well correlated with the symptoms of nerve root compression. The aim of our study is to determine primary radiological parameters associated with decreased FA values in patients with lumbar spinal stenosis involving single L5 nerve root. Patients confirmed with single L5 nerve root compression by transforaminal nerve root blocks were included in this study. FA values of L5 nerve roots on both symptomatic and asymptomatic side were obtained. Conventional radiological parameters, such as disc height, degenerative scoliosis, dural sac cross-sectional area (DSCSA), foraminal height (FH), hypertrophic facet joint degeneration (HFJD), sagittal rotation (SR), sedimentation sign, sagittal translation and traction spur were measured. Correlation and regression analyses were performed between the radiological parameters and FA values of the symptomatic L5 nerve roots. A predictive regression equation was established. Twenty-one patients were included in this study. FA values were significantly lower at the symptomatic side comparing to the asymptomatic side (0.263 ± 0.069 vs. 0.334 ± 0.080, P = 0.038). DSCSA, FH, HFJD, and SR were significantly correlated with the decreased FA values, with r = 0.518, 0.443, 0.472 and - 0.910, respectively (P values, and the regression equation is FA = - 0.012 × SR + 0.002 × DSCSA. DSCSA and SR were primary contributors to decreased FA values in LSS patients involving single L5 nerve root, indicating that central canal decompression and segmental stability should be the first considerations in preoperative planning of these patients. These slides can be retrieved under Electronic Supplementary Material.

Observations of copolar correlation coefficient through a bright band at vertical incidence

Science.gov (United States)

Zrnic, D. S.; Raghavan, R.; Chandrasekar, V.

1994-01-01

This paper discusses an application of polarimetric measurements at vertical incidence. In particular, the correlation coefficients between linear copolar components are examined, and measurements obtained with the National Severe Storms Laboratory (NSSL)'s and National Center for Atmospheric Research (NCAR)'s polarimetric radars are presented. The data are from two well-defined bright bands. A sharp decrease of the correlation coefficient, confined to a height interval of a few hundred meters, marks the bottom of the bright band.

Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease.

Science.gov (United States)

Peng, Ying; Qi, Yicheng; Huang, Fengjiao; Chen, Xinxin; Zhou, Yulin; Ye, Lei; Wang, Weiqing; Ning, Guang; Wang, Shu

2016-11-29

Resistin, belongs to cysteine-rich secretory protein, is mainly produced by circulating leukocytes, such as neutrophils monocytes and macrophages in humans. To date, few but controversial studies have reported about resistin concentrations in hyperthyroid patients, especially in Graves' disease (GD). We undertaked a controlled, prospective study to explore the serum resistin concentration in GD patients before and after -MMI treatment. In addition, we also investigated the main influencing factor on serum resistin level and discuessed the potential role of serum resistin plays in GD patients. 39 untreated GD (uGD) patients, including 8 males and 31 females, were enrolled in our investigation. All of these patients were prescribed with MMI treatment, in addition to 25 healthy controls. Anthropometric parameters and hormone assessment were measured. Enzyme-linked immunosorbent assay was used to detect serum resistin concentration in different stages of GD patients. Furthermore, neutrophil cell line NB4 with or without T3 treatment to detect the effect of thyroid hormones on resistin expression. The serum resistin level and neutrophil counts in untreated GD patients were significantly declined. And all of these parameters were recovered to normal after MMI treatment in ethyroid GD (eGD) and TRAb-negative conversion (nGD) patients. Resistin concentration exhibited a negative correlation with FT3 and FT4, but a positive correlation with absolute number of neutrophiles in uGD patients, whereas did not correlate with thyroid autoimmune antibodies and BMI. Neutrophile cell line, NB4, produced decreased expression of resistin when stimulated with T3. Our study showed a decrease of serum resistin level in GD patients and we suggested that the serum resistin might primarily secreted from circulating neutrophils and down-regulated by excessive thyroid hormones in GD patients.

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

International Nuclear Information System (INIS)

Mercado, Nicolas; Thimmulappa, Rajesh; Thomas, Catherine M.R.; Fenwick, Peter S.; Chana, Kirandeep K.; Donnelly, Louise E.; Biswal, Shyam; Ito, Kazuhiro; Barnes, Peter J.

2011-01-01

Research highlights: → Nrf2 anti-oxidant function is impaired when HDAC activity is inhibited. → HDAC inhibition decreases Nrf2 protein stability. → HDAC2 is involved in reduced Nrf2 stability and both correlate in COPD samples. → HDAC inhibition increases Nrf2 acetylation. -- Abstract: Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in cellular defence against oxidative stress by inducing the expression of multiple anti-oxidant genes. However, where high levels of oxidative stress are observed, such as chronic obstructive pulmonary disease (COPD), Nrf2 activity is reduced, although the molecular mechanism for this defect is uncertain. Here, we show that down-regulation of histone deacetylase (HDAC) 2 causes Nrf2 instability, resulting in reduced anti-oxidant gene expression and increase sensitivity to oxidative stress. Although Nrf2 protein was clearly stabilized after hydrogen peroxide (H 2 O 2 ) stimulation in a bronchial epithelial cell line (BEAS2B), Nrf2 stability was decreased and Nrf2 acetylation increased in the presence of an HDAC inhibitor, trichostatin A (TSA). TSA also reduced Nrf2-regulated heme-oxygenase-1 (HO-1) expression in these cells, and this was confirmed in acute cigarette-smoke exposed mice in vivo. HDAC2 knock-down by RNA interference resulted in reduced H 2 O 2 -induced Nrf2 protein stability and activity in BEAS2B cells, whereas HDAC1 knockdown had no effect. Furthermore, monocyte-derived macrophages obtained from healthy volunteers (non-smokers and smokers) and COPD patients showed a significant correlation between HDAC2 expression and Nrf2 expression (r = 0.92, p < 0.0001). Thus, reduced HDAC2 activity in COPD may account for increased Nrf2 acetylation, reduced Nrf2 stability and impaired anti oxidant defences.

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

Energy Technology Data Exchange (ETDEWEB)

Mercado, Nicolas [Airway Disease Section, National Heart and Lung Institute, Imperial College, London SW3 6LY (United Kingdom); Thimmulappa, Rajesh [Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (United States); Thomas, Catherine M.R.; Fenwick, Peter S.; Chana, Kirandeep K.; Donnelly, Louise E. [Airway Disease Section, National Heart and Lung Institute, Imperial College, London SW3 6LY (United Kingdom); Biswal, Shyam [Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (United States); Ito, Kazuhiro [Airway Disease Section, National Heart and Lung Institute, Imperial College, London SW3 6LY (United Kingdom); Barnes, Peter J., E-mail: p.j.barnes@imperial.ac.uk [Airway Disease Section, National Heart and Lung Institute, Imperial College, London SW3 6LY (United Kingdom)

2011-03-11

Research highlights: {yields} Nrf2 anti-oxidant function is impaired when HDAC activity is inhibited. {yields} HDAC inhibition decreases Nrf2 protein stability. {yields} HDAC2 is involved in reduced Nrf2 stability and both correlate in COPD samples. {yields} HDAC inhibition increases Nrf2 acetylation. -- Abstract: Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in cellular defence against oxidative stress by inducing the expression of multiple anti-oxidant genes. However, where high levels of oxidative stress are observed, such as chronic obstructive pulmonary disease (COPD), Nrf2 activity is reduced, although the molecular mechanism for this defect is uncertain. Here, we show that down-regulation of histone deacetylase (HDAC) 2 causes Nrf2 instability, resulting in reduced anti-oxidant gene expression and increase sensitivity to oxidative stress. Although Nrf2 protein was clearly stabilized after hydrogen peroxide (H{sub 2}O{sub 2}) stimulation in a bronchial epithelial cell line (BEAS2B), Nrf2 stability was decreased and Nrf2 acetylation increased in the presence of an HDAC inhibitor, trichostatin A (TSA). TSA also reduced Nrf2-regulated heme-oxygenase-1 (HO-1) expression in these cells, and this was confirmed in acute cigarette-smoke exposed mice in vivo. HDAC2 knock-down by RNA interference resulted in reduced H{sub 2}O{sub 2}-induced Nrf2 protein stability and activity in BEAS2B cells, whereas HDAC1 knockdown had no effect. Furthermore, monocyte-derived macrophages obtained from healthy volunteers (non-smokers and smokers) and COPD patients showed a significant correlation between HDAC2 expression and Nrf2 expression (r = 0.92, p < 0.0001). Thus, reduced HDAC2 activity in COPD may account for increased Nrf2 acetylation, reduced Nrf2 stability and impaired anti oxidant defences.

Correlation and network topologies in global and local stock indices

Science.gov (United States)

Nobi, Ashadun; Lee, Sungmin; Kim, Doo Hwan; Lee, Jae Woo

2014-07-01

We examined how the correlation and network structure of the global indices and local Korean indices have changed during years 2000-2012. The average correlations of the global indices increased with time, while the local indices showed a decreasing trend except for drastic changes during the crises. A significant change in the network topologies was observed due to the financial crises in both markets. The Jaccard similarities identified the change in the market state due to a crisis in both markets. The dynamic change of the Jaccard index can be used as an indicator of systemic risk or precursors of the crisis.

Inpatient Hematology-Oncology Rotation Is Associated With a Decreased Interest in Pursuing an Oncology Career Among Internal Medicine Residents.

Science.gov (United States)

McFarland, Daniel C; Holland, Jimmie; Holcombe, Randall F

2015-07-01

The demand for hematologists and oncologists is not being met. We hypothesized that an inpatient hematology-oncology ward rotation would increase residents' interest. Potential reasons mitigating interest were explored and included differences in physician distress, empathy, resilience, and patient death experiences. Agreement with the statement "I am interested in pursuing a career/fellowship in hematology and oncology" was rated by residents before and after a hematology-oncology rotation, with 0 = not true at all, 1 = rarely true, 2 = sometimes true, 3 = often true, and 4 = true nearly all the time. House staff rotating on a hematology-oncology service from November 2013 to October 2014 also received questionnaires before and after their rotations containing the Connors-Davidson Resilience Scale, the Impact of Events Scale-Revised, the Interpersonal Reactivity Index, demographic information, and number of dying patients cared for and if a sense of meaning was derived from that experience. Fifty-six residents completed both before- and after-rotation questionnaires (response rate, 58%). The mean interest score was 1.43 initially and decreased to 1.24 after the rotation (P = .301). Female residents' mean score was 1.13 initially and dropped to 0.81 after the rotation (P = .04). Male residents' mean score was 1.71 initially and 1.81 after the rotation (P = .65). Decreased hematology-oncology interest correlated with decreased empathy; male interest decrease correlated with decreased resilience. An inpatient hematology-oncology ward rotation does not lead to increased interest and, for some residents, may lead to decreased interest in the field. Encouraging outpatient hematology-oncology rotations and the cultivation of resilience, empathy, and meaning regarding death experiences may increase resident interest. Copyright © 2015 by American Society of Clinical Oncology.

Spatial correlation of atmospheric wind at scales relevant for large scale wind turbines

Science.gov (United States)

Bardal, L. M.; Sætran, L. R.

2016-09-01

Wind measurements a short distance upstream of a wind turbine can provide input for a feedforward wind turbine controller. Since the turbulent wind field will be different at the point/plane of measurement and the rotor plane the degree of correlation between wind speed at two points in space both in the longitudinal and lateral direction should be evaluated. This study uses a 2D array of mast mounted anemometers to evaluate cross-correlation of longitudinal wind speed. The degree of correlation is found to increase with height and decrease with atmospheric stability. The correlation is furthermore considerably larger for longitudinal separation than for lateral separation. The integral length scale of turbulence is also considered.

Statistical properties of cross-correlation in the Korean stock market

Science.gov (United States)

Oh, G.; Eom, C.; Wang, F.; Jung, W.-S.; Stanley, H. E.; Kim, S.

2011-01-01

We investigate the statistical properties of the cross-correlation matrix between individual stocks traded in the Korean stock market using the random matrix theory (RMT) and observe how these affect the portfolio weights in the Markowitz portfolio theory. We find that the distribution of the cross-correlation matrix is positively skewed and changes over time. We find that the eigenvalue distribution of original cross-correlation matrix deviates from the eigenvalues predicted by the RMT, and the largest eigenvalue is 52 times larger than the maximum value among the eigenvalues predicted by the RMT. The β_{473} coefficient, which reflect the largest eigenvalue property, is 0.8, while one of the eigenvalues in the RMT is approximately zero. Notably, we show that the entropy function E(σ) with the portfolio risk σ for the original and filtered cross-correlation matrices are consistent with a power-law function, E( σ) σ^{-γ}, with the exponent γ 2.92 and those for Asian currency crisis decreases significantly.

Correlation effects on spin-polarized electron-hole quantum bilayer

Energy Technology Data Exchange (ETDEWEB)

Saini, L. K., E-mail: drlalitsaini75@gmail.com; Sharma, R. O., E-mail: sharmarajesh0387@gmail.com [Department of Applied Physics, S. V. National Institute of Technology, Surat – 395 007 (India); Nayak, Mukesh G. [Department of Physics, Silvassa College (Silvassa Institute of Higher Learning), Silvassa 396 230 (India)

2016-05-06

We present a numerical calculation for the intra- and interlayer pair-correlation functions, g{sub ll’}(r), of spin-polarized electron-hole quantum bilayers at zero temperature. The calculations of g{sub ll’}(r) are performed by including electron correlations within the dynamical version of the self-consistent mean-field approximation of Singwi, Tosi, Land and Sjölander (qSTLS). Our study reveals that the critical layer density decreases (increases) due to the inclusion of finite width (mass-asymmetry) effect during the phase-transition from charge-density wave to Wigner crystal ground-state by yielding the pronounced oscillatory behavior ing{sub ll}(r). The results are compared with recent findings of spin-polarized electron-hole quantum bilayers with mass-symmetry and zero width effects. To highlight the importance of dynamical character of correlations, we have also compared our results with the STLS results.

Does acid-base equilibrium correlate with remnant liver volume during stepwise liver resection?

Science.gov (United States)

Golriz, Mohammad; Abbasi, Sepehr; Fathi, Parham; Majlesara, Ali; Brenner, Thorsten; Mehrabi, Arianeb

2017-10-01

Small for size and flow syndrome (SFSF) is one of the most challenging complications following extended hepatectomy (EH). After EH, hepatic artery flow decreases and portal vein flow increases per 100 g of remnant liver volume (RLV). This causes hypoxia followed by metabolic acidosis. A correlation between acidosis and posthepatectomy liver failure has been postulated but not studied systematically in a large animal model or clinical setting. In our study, we performed stepwise liver resections on nine pigs to defined SFSF limits as follows: step 1: segment II/III resection, step 2: segment IV resection, step 3: segment V/VIII resection (RLV: 75, 50, and 25%, respectively). Blood gas values were measured before and after each step using four catheters inserted into the carotid artery, internal jugular vein, hepatic artery, and portal vein. The pH, [Formula: see text], and base excess (BE) decreased, but [Formula: see text] values increased after 75% resection in the portal and jugular veins. EH correlated with reduced BE in the hepatic artery. Pco 2 values increased after 75% resection in the jugular vein. In contrast, arterial Po 2 increased after every resection, whereas the venous Po 2 decreased slightly. There were differences in venous [Formula: see text], BE in the hepatic artery, and Pco 2 in the jugular vein after 75% liver resection. Because 75% resection is the limit for SFSF, these noninvasive blood evaluations may be used to predict SFSF. Further studies with long-term follow-up are required to validate this correlation. NEW & NOTEWORTHY This is the first study to evaluate acid-base parameters in major central and hepatic vessels during stepwise liver resection. The pH, [Formula: see text], and base excess (BE) decreased, but [Formula: see text] values increased after 75% resection in the portal and jugular veins. Extended hepatectomy correlated with reduced BE in the hepatic artery. Because 75% resection is the limit for small for size and flow

African Burkitt lymphoma: age-specific risk and correlations with malaria biomarkers.

Science.gov (United States)

Emmanuel, Benjamin; Kawira, Esther; Ogwang, Martin D; Wabinga, Henry; Magatti, Josiah; Nkrumah, Francis; Neequaye, Janet; Bhatia, Kishor; Brubaker, Glen; Biggar, Robert J; Mbulaiteye, Sam M

2011-03-01

African Burkitt lymphoma is an aggressive B-cell, non-Hodgkin lymphoma linked to Plasmodium falciparum malaria. Malaria biomarkers related to onset of African Burkitt lymphoma are unknown. We correlated age-specific patterns of 2,602 cases of African Burkitt lymphoma (60% male, mean ± SD age = 7.1 ± 2.9 years) from Uganda, Ghana, and Tanzania with malaria biomarkers published from these countries. Age-specific patterns of this disease and mean multiplicity of P. falciparum malaria parasites, defined as the average number of distinct genotypes per positive blood sample based on the merozoite surface protein-2 assessed by polymerase chain reaction, were correlated and both peaked between 5 and 9 years. This pattern, which was strong and consistent across regions, contrasted parasite prevalence, which peaked at 2 years and decreased slightly, and geometric mean parasite density, which peaked between 2 and 3 years and decreased sharply. Our findings suggest that concurrent infection with multiple malaria genotypes may be related to onset of African Burkitt lymphoma.

Is decreased diameter of renal pelvis in prone position an indicator of successful pyeloplasty?

International Nuclear Information System (INIS)

Sharma, Gyanendra; Sharma, Anshu; Leung, Vivian Yee-Fong; Chu, Winnie Chiu-Wing

2016-01-01

To evaluate patients who had undergone pyeloplasty for pelviureteric junction obstruction, by measuring the anteroposterior diameter (APD) of the renal pelvis in supine and prone positions, and determine whether a decrease in APD in prone position can exclude obstruction in dilated renal system. From January 2012 to December 2013, patients who had undergone pyeloplasty were evaluated by ultrasound in two centers. The difference of APD of the renal pelvis in supine and prone positions was obtained. Correlation was made with the pre- and post-pyeloplasty renal function by radionuclide renogram. There were 42 patients (31 males, 11 females; age range 5 months to 18 years). Residual hydronephrosis was detected in 41 patients of whom 35 patients (85%) showed decrease in APD by >10% in prone position. These patients and the one without hydronephrosis showed either no deterioration or improvement in renal function. Six patients (15%) showed either no change or increase in APD in prone position. Three patients (7.5%) were confirmed to have decrease in renal function indicating obstruction. Three patients (7.5%) showed no deterioration of renal function, but sluggish drainage on radionuclide renogram. Demonstration of decreased APD of renal pelvis in prone position by ultrasound is useful to differentiate obstructed from non-obstructed dilated renal system, and it correctly identified 85% candidates with successful pyeloplasty. In patients with no decrease or increase in APD at prone position, further follow-up is recommended to rule out obstruction

Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge.

Science.gov (United States)

Stokes, Paul R A; Egerton, Alice; Watson, Ben; Reid, Alistair; Breen, Gerome; Lingford-Hughes, Anne; Nutt, David J; Mehta, Mitul A

2010-10-01

Delta9-tetrahydrocannabinol (THC) increases prefrontal cortical dopamine release in animals, but this is yet to be examined in humans. In man, striatal dopamine release can be indexed using [11C]-raclopride positron emission tomography (PET), and recent reports suggest that cortical [11C]-raclopride binding may also be sensitive to dopaminergic challenges. Using an existing dataset we examined whether THC alters [11C]-raclopride binding potential (BP(ND)) in cortical regions. Thirteen healthy volunteers underwent two [11C]-raclopride PET scans following either oral 10 mg THC or placebo. Significant areas of decreased cortical [11C]-raclopride BP(ND) were identified using whole brain voxel-wise analysis and quantified using a region of interest (ROI) ratio analysis. Effect of blood flow on binding was estimated using a simplified reference tissue model analysis. Results were compared to [11C]-raclopride test-retest reliability in the ROIs identified using a separate cohort of volunteers. Voxel-wise analysis identified three significant clusters of decreased [11C]-raclopride BP(ND) after THC in the right middle frontal gyrus, left superior frontal gyrus and left superior temporal gyrus. Decreases in [11C]-raclopride BPND following THC were greater than test-retest variability in these ROIs. R1, an estimate of blood flow, significantly decreased in the left superior frontal gyrus in the THC condition but was unchanged in the other ROIs. Decreased frontal binding significantly correlated to catechol-o-methyl transferase (COMT) val108 status. We have demonstrated for the first time significant decreases in bilateral frontopolar cortical and left superior temporal gyrus [11C]-raclopride binding after THC. The interpretation of these findings in relation to prefrontal dopamine release is discussed. Copyright 2010 Elsevier Inc. All rights reserved.

Svrchovanost povrchu. O distribuci smyslu v jedné literární recenzi // The sovereignty of the surface

Directory of Open Access Journals (Sweden)

Jakub Blecha

2016-11-01

Full Text Available The article starts from an interpretation of the famous review of James Joyce’s Ulysses by Carl Gustav Jung called “Ulysses: A Monologue”. It focuses mainly on the comparison of the semiological assumptions of the two authors. Although both are aware of the principle of openness and fluidity of the text, it is evident, that their hypotheses, submitted to justify this view, do not have the same efficiency. The article can be also read as an attempt to articulate the so called „serial method“, i. e. the Deleuzian critique of the concept of representation from the Logic of Sense. From this point of view, the article could be considered a contribution to the poststructuralist discussion of the concept of sense.

Smoking decreases the level of circulating CD34+ progenitor cells in young healthy women - a pilot study

Directory of Open Access Journals (Sweden)

Baumann Gert

2010-05-01

Full Text Available Abstract Background Decreased levels of circulating bone marrow-derived progenitor cells have been associated with risk factors and cardiovascular diseases. Smoking is the most important modifiable risk factor for atherosclerosis in young women. The aim of this pilot study was to assess in healthy premenopausal women without other risk factors for cardiovascular disease the influence of nicotine abuse on the number of circulating progenitor cells in relation to endothelial function. Methods The number of endothelial progenitor cells, measured as colony-forming units in a cell-culture assay (EPC-CFU and the number of circulating CD34 + and CD34 + /CD133 + cells, measured by flow cytometry, was estimated in 32 women at the menstrual phase of the menstrual cycle. In addition, flow-mediated dilation (FMD was assessed as a marker for vascular function. In a subgroup of these women (n = 20, progenitor cells were also investigated at the mid-follicular and luteal phases of the menstrual cycle. Results Compared to non-smokers, the abundance of circulating CD34 + cells was significantly lower in smoking women in the menstrual, mid-luteal, and mid-follicular phases of the menstrual cycle. The number of CD34 + progenitor cells was revealed to have significant positive correlation with FMD in young healthy women, whereas CD34 + /CD133 + progenitor cells and EPC-CFU showed no significant correlation. Conclusion The number of CD34 + progenitor cells positively correlates with FMD in young healthy women and is decreased by smoking.

The Secant Rate of Corrosion: Correlating Observations of the USS Arizona Submerged in Pearl Harbor

Science.gov (United States)

Johnson, Donald L.; DeAngelis, Robert J.; Medlin, Dana J.; Johnson, Jon E.; Carr, James D.; Conlin, David L.

2018-03-01

Contrary to previous linear projections of steel corrosion in seawater, analysis of an inert marker embedded in USS Arizona concretion since the 7 December 1941 attack on Pearl Harbor reveals evidence that the effective corrosion rate decreases with time. The secant rate of corrosion, or SRC correlation, derived from this discovery could have a significant impact on failure analysis investigations for concreted shipwrecks or underwater structures. The correlation yields a lower rate of metal thinning than predicted. Development of the correlation is described.

High-dose vitamin B6 decreases homocysteine serum levels in patients with schizophrenia and schizoaffective disorders: a preliminary study.

Science.gov (United States)

Miodownik, Chanoch; Lerner, Vladimir; Vishne, Tali; Sela, Ben-Ami; Levine, Joseph

2007-01-01

Vitamin B6 plays an essential role in the normal functioning of the central nervous system. Normal homocysteine (Hcy) serum level is maintained by remethylation of Hcy to methionine by enzymes that require folic acid and vitamin B12 and by catabolism to cysteine by a vitamin B6-dependent enzyme. These findings may be consistent with the hypothesis that the vitamin B6 status may influence plasma Hcy levels. The aims of this preliminary study were (1) to determine whether a correlation exists between Hcy and vitamin B6 levels in patients with schizophrenia and schizoaffective disorders and (2) to investigate whether treatment with high-dose vitamin B6 may reduce Hcy levels in these patients. In this preliminary study, we enrolled 11 patients with schizophrenia or schizoaffective disorders (7 men and 4 women; mean age +/- SD, 50 +/- 12 years) receiving high doses of vitamin B6 treatment (1200 mg/d) for 12 weeks. Blood samples for the assessment of pyridoxal-5-phosphate and Hcy serum levels were obtained at baseline and after 12 weeks of treatment. Age was significantly positively correlated with Hcy levels at baseline (r = 0.392, P = 0.004). All other parameters, including diagnosis, disease duration, and pyridoxal-5-phosphate serum level, were not correlated with Hcy serum levels at baseline. After vitamin B6 treatment, Hcy serum levels significantly decreased (14.2 +/- 3.4 vs. 11.8 +/- 2.0 micromol/L, respectively, t = 2.679, P = 0.023); this decrease being statistically significant in men but not in women. High doses of vitamin B6 lead to a decrease in Hcy serum level in male patients with schizophrenia or schizoaffective disorder.

Pair correlation of super-deformed rotation band

International Nuclear Information System (INIS)

Shimizu, Yoshio

1989-01-01

The effect of pair correlation, one of the most important residual interactions associated with the super-deformed rotation band, is discussed in terms of the characteristics of the rotation band (its effect on the moment of inertia in particular), and the tunneling into an normal deformed state in relation to its effect on the angular momentum dependence of the potential energy plane as a function of the deformation. The characteristics of the rotation band is discussed in terms of the kinematic and dynamic momenta of inertia. It is shown that the pair correlation in a super-deformed rotation band acts to decrease the former and increase the latter momentum mainly due to dynamic pair correlation. A theoretical approach that takes this effect into account can provide results that are consistent with measured momenta, although large differences can occur in some cases. Major conflicts include a large measured kinetic momentum of inertia compared to the theoretical value, and the absence of the abnormality (shape increase) generally seen in low-spin experiments. The former seems likely to be associated with the method of measuring the angular momentum. (N.K.)

Voluntary running-wheel exercise decreases the threshold for rewarding intracranial self-stimulation.

Science.gov (United States)

Morris, Michael J; Na, Elisa S; Johnson, Alan Kim

2012-08-01

Physical exercise has mood-enhancing and antidepressant properties although the mechanisms underlying these effects are not known. The present experiment investigated the effects of prolonged access to a running wheel on electrical self-stimulation of the lateral hypothalamus (LHSS), a measure of hedonic state, in rats. Rats with continuous voluntary access to a running wheel for either 2 or 5 weeks exhibited dramatic leftward shifts in the effective current 50 (ECu50; current value that supports half of maximum responding) of their LHSS current-response functions compared to their baselines, indicating a decrease in reward threshold, whereas control rats current-response functions after 2 or 5 weeks were not significantly different from baseline. An inverse correlation existed between the change in ECu50 from baseline and the amount an animal had run in the day prior to LHSS testing, indicating that animals that exhibited higher levels of running showed a more robust decrease in LHSS threshold. We conclude that long-term voluntary exercise increases sensitivity to rewarding stimuli, which may contribute to its antidepressant properties.

Clinical correlates of first episode early onset psychosis in KwaZulu ...

African Journals Online (AJOL)

Background: The study of first episode early onset psychosis can yield many clues to understanding the early development of psychosis and guide interventions to decrease psychosis risk and improve outcome. The aim of the study was to investigate the socio-demographic profile and clinical correlates in early onset ...

Decreasing Serial Cost Sharing

DEFF Research Database (Denmark)

Hougaard, Jens Leth; Østerdal, Lars Peter

The increasing serial cost sharing rule of Moulin and Shenker [Econometrica 60 (1992) 1009] and the decreasing serial rule of de Frutos [Journal of Economic Theory 79 (1998) 245] have attracted attention due to their intuitive appeal and striking incentive properties. An axiomatic characterization...... of the increasing serial rule was provided by Moulin and Shenker [Journal of Economic Theory 64 (1994) 178]. This paper gives an axiomatic characterization of the decreasing serial rule...

Decreasing serial cost sharing

DEFF Research Database (Denmark)

Hougaard, Jens Leth; Østerdal, Lars Peter Raahave

2009-01-01

The increasing serial cost sharing rule of Moulin and Shenker (Econometrica 60:1009-1037, 1992) and the decreasing serial rule of de Frutos (J Econ Theory 79:245-275, 1998) are known by their intuitive appeal and striking incentive properties. An axiomatic characterization of the increasing serial...... rule was provided by Moulin and Shenker (J Econ Theory 64:178-201, 1994). This paper gives an axiomatic characterization of the decreasing serial rule....

Decreased surface albedo driven by denser vegetation on the Tibetan Plateau

International Nuclear Information System (INIS)

Tian, Li; Zhang, Yangjian; Zhu, Juntao

2014-01-01

The Tibetan Plateau (TP) has fundamental ecological and environmental significance to China and Asia through its influence on regional and continental climates. In recent years, climate warming has caused unprecedented changes to land surface processes on the TP, which would unavoidably undermine the ecological and environmental functions of the TP. Among the numerous land surface processes potentially impacted by climate warming, the effect of vegetation greenness on surface energy balance is one of the most critical, but has been long ignored. In this study, we investigated the spatial and temporal patterns of land surface albedo (LSA) on the TP and evaluated the vegetation greenness in relation to patterns of LSA. We found that LSA has been decreasing in most of the vegetated grasslands on the TP from 2000 to 2013, as compared to a flat trend for desert area. The regions where LSA has been decreasing were spatially correlated to areas of increased vegetation greenness. Along rising altitude, LSA decreasing rate exhibited an overall decreasing trend. Across the TP, elevated vegetation greenness in grasslands acted as a primary factor pulling down LSA. The driving effects of vegetation greenness on LSA vary with grassland types, as revealed by a more significant relationship between vegetation greenness and LSA for the sparsely vegetated zone (i.e. steppe) than the more densely vegetated zone (i.e. meadow). Furthermore, the driving effect of vegetation greenness on LSA exhibited an obvious dependence on altitude as effects with rising altitude were relatively strong up to 3000 m, then weakened from 3500 m to 5000 m, and then the effects again increased from 5000 to 6000 m. The growing season LSA trend revealed in this study emphasizes the need to give greater attention to the growing season LSA flux in future surface energy balance studies. (letter)

Atorvastatin correlates with decreased risk of esophageal cancer: A ...

African Journals Online (AJOL)

Objectives: The aim of this study was to explore the association between the use of statins and esophageal cancer in Taiwan. Methods: We designed a casecontrol study using database from the Taiwan National Health Insurance program. In all, 549 patients (cases) aged 20 years or older diagnosed recently with ...

Emotional and Intellectual Correlates of Unsuccessful Suicide Attempts in People with Epilepsy.

Science.gov (United States)

Batzel, Lawrence W.; Dodrill, Carl B.

1986-01-01

Evaluated emotional and intellectual correlates of unsuccessful suicide attempts in persons with seizure disorders. Minnesota Multiphasic Personality Inventory Scores demonstrated increased anxiety and decreased ego strength among those with histories of suicide attempts, while intellectual abilities as evaluated by the Wechsler Adult Intelligence…

Chronic stress and decreased physical exercise: impact on weight for African American women.

Science.gov (United States)

Moore-Greene, Gracie M; Gross, Susan M; Silver, Kristi D; Perrino, Carrol S

2012-01-01

African American women continue to have the highest prevalence of obesity in the United States and in the state of Maryland they are disproportionately affected by overweight and obesity. There are many contributing factors including chronic stress and the use of health behaviors such as physical exercise that play a role in increased weight for African American women. We examined the relationship of stress to weight and the role of physical exercise in African American paraprofessional women. Cross-sectional study African American paraprofessionals were asked about their perspectives regarding association with chronic stress and physical exercise. The three most salient stressors for the women were finances (33%), work (28%) and family/friends (19%). Ninety percent of the women were overweight or obese. Significant predictors of increased BMI were lack of physical exercise (P = .004) and health compared to others (P = .006). Ethnic discrimination was a form of chronic stress (r = .319) but was not correlated with BMI (r = .095). Decreased physical exercise (P = .02) mediated the relationship between chronic stress and BMI. Findings regarding finance and work stress suggest the need for employers to consider the impact of job strain when implementing employee health programs to decrease stress and improve health. A focus on decreased physical exercise, unhealthy eating habits and misperceptions regarding increased risk for obesity related diseases with health status may be helpful to include in intervention strategies to decrease obesity for this population.

Correlation Between Lumbopelvic and Sagittal Parameters and Health-Related Quality of Life in Adults With Lumbosacral Spondylolisthesis.

Science.gov (United States)

Gussous, Yazeed; Theologis, Alexander A; Demb, Joshua B; Tangtiphaiboontana, Jennifer; Berven, Sigurd

2018-02-01

Secondary analysis of prospective, multicenter data. To evaluate impact of sagittal parameters on health-related quality of life (HRQoL) in adults with lumbosacral spondylolisthesis. Adults with unoperated lumbosacral spondylolisthesis were identified in the Spinal Deformity Study Group database. Pearson's correlations were calculated between SF-12 (Short Form-12)/Scoliosis Research Society-30 (SRS-30) scores and radiographic parameters (C7 sagittal vertical axis [SVA] deviation, T1 pelvic angle, pelvic tilt [PT], pelvic incidence, sacral slope, slip angle, Meyerding slip grade, Labelle classification). Main effects linear regression models measured association between individual health status measures and individual radiographic predictor variables. Forty-five patients were analyzed (male, 15; female, 30; average age 40.5 ± 18.7 years; 14 low-grade, 31 high-grade). For low-grade slips, SVA had strong negative correlations with SF-12 mental component score (MCS), SRS-30 appearance, mental, and satisfaction domains ( r = -0.57, r = -0.60, r = -0.58, r = -0.53, respectively; P grade slips, slip angle had a moderate negative correlation with SF-12 MCS ( r = -0.36; P = .05) and SVA had strong negative correlations with SF-12 physical component score (PCS), SRS-30 appearance and activity domains ( r = -0.48, r = -0.48, r = -0.45; P point decrease in SRS appearance, 0.05-point decrease in SRS activity, 0.06-point decrease in SRS satisfaction, and 0.04-point decrease in SRS total score ( P grade slips. Improvement of sagittal parameters is an important goal of surgery for adults with lumbosacral spondylolisthesis.

Effect of disorder with long-range correlation on transport in graphene nanoribbon

International Nuclear Information System (INIS)

Zhang, G P; Gao, M; Shangguan, M H; Zhang, Y Y; Liu, N; Qin, Z J

2012-01-01

Transport in disordered armchair graphene nanoribbons (AGR) with long-range correlation between quantum wire contacts is investigated by a transfer matrix combined with Landauer’s formula. The metal-insulator transition is induced by disorder in neutral AGR. Therein, the conductance is one conductance quantum for the metallic phase and exponentially decays otherwise, when the length of AGR approaches infinity and far longer than its width. Similar to the case of long-range disorder, the conductance of neutral AGR first increases and then decreases while the conductance of doped AGR monotonically decreases, as the disorder strength increases. In the presence of strong disorder, the conductivity depends monotonically and non-monotonically on the aspect ratio for heavily doped and slightly doped AGR, respectively. For edge disordered graphene nanoribbon, the conductance increases with the disorder strength of long-range correlated disordered while no delocalization exists, since the edge disorder induces localization. (paper)

About long range pairing correlations in the Hubbard U-t-t' models

International Nuclear Information System (INIS)

Moreo, A.

1991-01-01

Using a quantum Monte Carlo method the authors measured pair correlation functions with different symmetries as a function of the filling, U/t and t'/t for the Hubbard and U-t-t' models. For the first time the Monte Carlo results are presented for U/t larger than the bandwidth 8t, away from half-filling. D-wave and extended S-wave pairing correlations are enhanced. D-wave pairing is stronger at half-filling but this behavior is reversed when the filling decreases. However, none of the eight pairing correlations that were studied increases as a function of lattice size, which makes the existence of long range superconducting order unlikely. (author). 10 refs.; 5 figs

Mitochondrial mass is inversely correlated to complete lipid oxidation in human myotubes

DEFF Research Database (Denmark)

Gaster, Michael

2011-01-01

Exercise increases while physical inactivity decrease mitochondrial content and oxidative capacity of skeletal muscles in vivo. It is unknown whether mitochondrial mass and substrate oxidation are related in non-contracting skeletal muscle. Mitochondrial mass, ATP, ADP, AMP, glucose and lipid......, basal glucose oxidation and incomplete lipid oxidation were significantly increased while complete lipid oxidation was lower. Mitochondrial mass was not correlated to glucose oxidation or incomplete lipid oxidation in human myotubes but inversely correlated to complete lipid oxidation. Thus within...... a stable energetic background, an increased mitochondrial mass in human myotubes was not positive correlated to an increased substrate oxidation as expected from skeletal muscles in vivo but surprisingly with a reduced complete lipid oxidation....

Correlation and network topologies in global and local stock indices

DEFF Research Database (Denmark)

Nobi, A.; Lee, S.; Kim, D. H.

2014-01-01

the crises. A significant change in the network topologies was observed due to the financial crises in both markets. The Jaccard similarities identified the change in the market state due to a crisis in both markets. The dynamic change of the Jaccard index can be used as an indicator of systemic risk......We examined how the correlation and network structure of the global indices and local Korean indices have changed during years 2000-2012. The average correlations of the global indices increased with time, while the local indices showed a decreasing trend except for drastic changes during...... or precursors of the crisis. (C) 2014 Elsevier B.V. All rights reserved....

Fishing in the Holy Waters.

Science.gov (United States)

Lipschultz, Geri

1986-01-01

Describes a teaching method that uses Molly Bloom's soliloquy from James Joyce's "Ulysses" to teach punctuation to freshman writing students. Argues that the assignment helps students discover their power as orderers. (EL)

Glacier albedo decrease in the European Alps: potential causes and links with mass balances

Science.gov (United States)

Di Mauro, Biagio; Julitta, Tommaso; Colombo, Roberto

2016-04-01

Both mountain glaciers and polar ice sheets are losing mass all over the Earth. They are highly sensitive to climate variation, and the widespread reduction of glaciers has been ascribed to the atmospheric temperature increase. Beside this driver, also ice albedo plays a fundamental role in defining mass balance of glaciers. In fact, dark ice absorbs more energy causing faster glacier melting, and this can drive to more negative balances. Previous studies showed that the albedo of Himalayan glaciers and the Greenland Ice Sheet is decreasing with important rates. In this contribution, we tested the hypothesis that also glaciers in the European Alps are getting darker. We analyzed 16-year time series of MODIS (MODerate resolution Imaging Spectrometer) snow albedo from Terra (MOD13A1, 2000-2015) and Aqua (MYD13A1, 2002-2015) satellites. These data feature a spatial resolution of 500m and a daily temporal resolution. We evaluated the existence of a negative linear and nonlinear trend of the summer albedo values both at pixel and at glacier level. We also calculated the correlation between MODIS summer albedo and glacier mass balances (from the World Glaciological Monitoring Service, WGMS database), for all the glaciers with available mass balance during the considered period. In order to estimate the percentage of the summer albedo that can be explained by atmospheric temperature, we correlated MODIS albedo and monthly air temperature extracted from the ERA-Interim reanalysis dataset. Results show that decreasing trends exist with a strong spatial variability in the whole Alpine chain. In large glaciers, such as the Aletch (Swiss Alps), the trend varies significantly also within the glacier, showing that the trend is higher in the area across the accumulation and ablation zone. Over the 17 glaciers with mass balance available in the WGMS data set, 11 gave significant relationship with the MODIS summer albedo. Moreover, the comparison between ERA-Interim temperature

Decreasing cloud cover drives the recent mass loss on the Greenland Ice Sheet.

Science.gov (United States)

Hofer, Stefan; Tedstone, Andrew J; Fettweis, Xavier; Bamber, Jonathan L

2017-06-01

The Greenland Ice Sheet (GrIS) has been losing mass at an accelerating rate since the mid-1990s. This has been due to both increased ice discharge into the ocean and melting at the surface, with the latter being the dominant contribution. This change in state has been attributed to rising temperatures and a decrease in surface albedo. We show, using satellite data and climate model output, that the abrupt reduction in surface mass balance since about 1995 can be attributed largely to a coincident trend of decreasing summer cloud cover enhancing the melt-albedo feedback. Satellite observations show that, from 1995 to 2009, summer cloud cover decreased by 0.9 ± 0.3% per year. Model output indicates that the GrIS summer melt increases by 27 ± 13 gigatons (Gt) per percent reduction in summer cloud cover, principally because of the impact of increased shortwave radiation over the low albedo ablation zone. The observed reduction in cloud cover is strongly correlated with a state shift in the North Atlantic Oscillation promoting anticyclonic conditions in summer and suggests that the enhanced surface mass loss from the GrIS is driven by synoptic-scale changes in Arctic-wide atmospheric circulation.

Combat Stress Decreases Memory of Warfighters in Action.

Science.gov (United States)

Delgado-Moreno, Rosa; Robles-Pérez, José Juan; Clemente-Suárez, Vicente Javier

2017-08-01

The present research aimed to analyze the effect of combat stress in the psychophysiological response and attention and memory of warfighters in a simulated combat situation. Variables of blood oxygen saturation, heart rate, blood glucose, blood lactate, body temperature, lower body muscular strength manifestation, cortical arousal, autonomic modulation, state anxiety and memory and attention through a postmission questionnaire were analyzed before and after a combat simulation in 20 male professional Spanish Army warfighters. The combat simulation produces a significant increase (p body temperature post, HF post/correct sound, body temperature post/glucose post, CFFTpre/lactate post, CFFT post/wrong sound, glucose post/AC pre, AC post/wrong fusil, AS post/SC post and SC post/wrong olfactory; and negative correlations: LF post/correct sound, body temperature post/lactate post and glucose post/lactate post. This data suggest that combat stress actives fight-flight system of soldiers. As conclusion, Combat stress produces an increased psychophysiological response that cause a selective decrease of memory, depending on the nature, dangerous or harmless of the objects.

CORRELATIONS OF DISK AND JET EMISSION DEVIATING FROM THE FUNDAMENTAL PLANE

Energy Technology Data Exchange (ETDEWEB)

Lin, Da-Bin; Mu, Hui-Jun; Lu, Zu-Jia; Liang, En-Wei [GXU-NAOC Center for Astrophysics and Space Sciences, Department of Physics, Guangxi University, Nanning 530004 (China); Gu, Wei-Min; Ma, Ren-Yi, E-mail: lindabin@gxu.edu.cn [Department of Astronomy and Institute of Theoretical Physics and Astrophysics, Xiamen University, Xiamen, Fujian 361005 (China)

2015-07-01

The variability of the accretion rate, which is believed to induce the aperiodic variability of X-ray emission from disks, may affect the energy injection into a jet. In this spirit, a correlation between disk emission and jet emission can be formed even if the mean luminosity of disk emission remains constant. In this work, these correlations are found in the situation in which the luminosity of disk emission is variable and kept at a constant mean value. The obtained correlations may be shallower than that of the fundamental plane of black hole activity. In addition, the slope of correlation may increase with increasing observed frequency of jet emission. For the luminosities spaced over three days, the slope of correlation decreases with increasing black hole mass. The deviation of our found correlations from that of the fundamental plane is related to the suppression of variability in the jet emission in comparison with that in the disk emission. This mechanism may work in some sources in which shallower correlations have been reported. Moreover, it implies that luminosities used to estimate the relation of the fundamental plane should cover an appropriate timescale, in which the variability of jet emission is not significantly suppressed.

Decreased expression of indolamine 2,3-dioxygenase in childhood allergic asthma and its inverse correlation with fractional concentration of exhaled nitric oxide.

Science.gov (United States)

Hu, Ying; Chen, Zhiqiang; Jin, Ling; Wang, Mei; Liao, Wei

2017-11-01

The tryptophan metabolic pathway mediated by indolamine 2,3-dioxygenase (IDO), a tryptophan-degrading enzyme, plays an important role in controlling the development of allergic inflammation. The fractional concentration of exhaled nitric oxide (FeNO) is closely associated with the allergic state and is extensively used for the clinical evaluation of airway allergic inflammation. Clinical trials have rarely assessed the expression of IDO in childhood allergic asthma and its correlation with FeNO. To evaluate the IDO level in children with childhood allergic asthma and the relation between IDO levels and FeNO. Thirty children older than 5 years who were diagnosed the first time with allergic asthma were selected from the pediatric outpatient department. Another 30 healthy children were selected as controls. The subjects were evaluated by complete medical history, pulmonary function test results, skin prick test reaction, FeNO concentration test result, eosinophil count, and a disease severity score. Peripheral venous blood and induced sputum were obtained to measure the concentrations of IDO metabolites (ie, tryptophan and kynurenine). The IDO levels in the peripheral blood and induced sputum were significantly lower in patients with childhood allergic asthma than in children in the control group. The IDO level was negatively correlated with FeNO but was not significantly correlated with age, sex, blood eosinophil count, or disease severity scale. The expression of IDO was significantly lower in childhood allergic asthma, particularly in children with high FeNO levels. There was no significant relation between IDO levels and asthma severity. Chinese Clinical Trial Register (www.chictr.org.cn) Identifier: ChiCTR-COC-15006080. Copyright © 2017 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Analysis of Current HT9 Creep Correlations and Modification

International Nuclear Information System (INIS)

Lee, Cheol Min; Sohn, Dongseong; Cheon, Jin Sik

2014-01-01

It has high thermal conductivity, high mechanical strength and low irradiation induced swelling. However high temperature creep of HT9 has always been a life limiting factor. Above 600 .deg. C, the dislocation density in HT9 is decreased and the M 23 C 6 precipitates coarsen, these processes are accelerated if there is irradiation. Finally microstructural changes at high temperature lead to lower creep strength and large creep strain. For HT9 to be used as a future cladding, creep behavior of the HT9 should be predicted accurately based on the physical understanding of the creep phenomenon. Most of the creep correlations are composed of irradiation creep and thermal creep terms. However, it is certain that in-pile thermal creep and out-of-pile thermal creep are different because of the microstructure changes induced from neutron irradiation. To explain creep behavior more accurately, thermal creep contributions other than neutron irradiation should be discriminated in a creep correlation. To perform this work, existing HT9 creep correlations are analyzed, and the results are used to develop more accurate thermal creep correlation. Then, the differences between in-pile thermal creep and out-of-pile thermal creep are examined

A decrease in cyclin B1 levels leads to polyploidization in DNA damage-induced senescence.

Science.gov (United States)

Kikuchi, Ikue; Nakayama, Yuji; Morinaga, Takao; Fukumoto, Yasunori; Yamaguchi, Naoto

2010-05-04

Adriamycin, an anthracycline antibiotic, has been used for the treatment of various types of tumours. Adriamycin induces at least two distinct types of growth repression, such as senescence and apoptosis, in a concentration-dependent manner. Cellular senescence is a condition in which cells are unable to proliferate further, and senescent cells frequently show polyploidy. Although abrogation of cell division is thought to correlate with polyploidization, the mechanisms underlying induction of polyploidization in senescent cells are largely unclear. We wished, therefore, to explore the role of cyclin B1 level in polyploidization of Adriamycin-induced senescent cells. A subcytotoxic concentration of Adriamycin induced polyploid cells having the features of senescence, such as flattened and enlarged cell shape and activated beta-galactosidase activity. In DNA damage-induced senescent cells, the levels of cyclin B1 were transiently increased and subsequently decreased. The decrease in cyclin B1 levels occurred in G2 cells during polyploidization upon treatment with a subcytotoxic concentration of Adriamycin. In contrast, neither polyploidy nor a decrease in cyclin B1 levels was induced by treatment with a cytotoxic concentration of Adriamycin. These results suggest that a decrease in cyclin B1 levels is induced by DNA damage, resulting in polyploidization in DNA damage-induced senescence.

Ignoring correlation in uncertainty and sensitivity analysis in life cycle assessment: what is the risk?

Energy Technology Data Exchange (ETDEWEB)

Groen, E.A., E-mail: Evelyne.Groen@gmail.com [Wageningen University, P.O. Box 338, Wageningen 6700 AH (Netherlands); Heijungs, R. [Vrije Universiteit Amsterdam, De Boelelaan 1105, Amsterdam 1081 HV (Netherlands); Leiden University, Einsteinweg 2, Leiden 2333 CC (Netherlands)

2017-01-15

Life cycle assessment (LCA) is an established tool to quantify the environmental impact of a product. A good assessment of uncertainty is important for making well-informed decisions in comparative LCA, as well as for correctly prioritising data collection efforts. Under- or overestimation of output uncertainty (e.g. output variance) will lead to incorrect decisions in such matters. The presence of correlations between input parameters during uncertainty propagation, can increase or decrease the the output variance. However, most LCA studies that include uncertainty analysis, ignore correlations between input parameters during uncertainty propagation, which may lead to incorrect conclusions. Two approaches to include correlations between input parameters during uncertainty propagation and global sensitivity analysis were studied: an analytical approach and a sampling approach. The use of both approaches is illustrated for an artificial case study of electricity production. Results demonstrate that both approaches yield approximately the same output variance and sensitivity indices for this specific case study. Furthermore, we demonstrate that the analytical approach can be used to quantify the risk of ignoring correlations between input parameters during uncertainty propagation in LCA. We demonstrate that: (1) we can predict if including correlations among input parameters in uncertainty propagation will increase or decrease output variance; (2) we can quantify the risk of ignoring correlations on the output variance and the global sensitivity indices. Moreover, this procedure requires only little data. - Highlights: • Ignoring correlation leads to under- or overestimation of the output variance. • We demonstrated that the risk of ignoring correlation can be quantified. • The procedure proposed is generally applicable in life cycle assessment. • In some cases, ignoring correlation has a minimal effect on decision-making tools.

Konec sluneční odyssey

Czech Academy of Sciences Publication Activity Database

Andréeová, K.; Švanda, Michal

2009-01-01

Roč. 15, č. 2 (2009), s. 30-33 ISSN 1211-0485 Institutional research plan: CEZ:AV0Z10030501 Keywords : solar wind * ulysses * interplanetary matter Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

Decrease of 5-Hydroxymethylcytosine in Rat Liver with Subchronic Exposure to Genotoxic Carcinogens Riddelliine and Aristolochic Acid

Science.gov (United States)

Lian, Christine Guo; Xu, Shuyun; Guo, Weimin; Yan, Jian; Frank, Maximilian Y M; Liu, Robert; Liu, Cynthia; Chen, Ying; Murphy, George F.; Chen, Tao

2018-01-01

The level of 5-hydroxymethylcytosine (5-hmC) converted by ten-eleven translocation (TET) family is decreased in cancers. However, whether 5-hmC level is perturbed in early stages of carcinogenesis caused by genotoxic carcinogens is not defined. 5-hmC levels and TET2 expression were measured in liver of rats treated with genotoxic carcinogens, riddelliine, or aristolochic acid. Levels of 5-hmC and TET2 expression decreased in the liver of the carcinogens-treated rats. Loss of 5-hmC correlates well with documented induction of genetic mutations by the carcinogens, suggesting that TET2-mediated 5-hydroxymethylation plays an epigenetic role in early state of carcinogenesis. PMID:25154389

Correlation-study about the ambient dose rate and the weather conditions

Science.gov (United States)

Furuya, Masato; Hatano, Yuko; Aoyama, Tomoo; Igarashi, Yasuhito; Kita, Kazuyuki; Ishizuka, Masahide

2016-04-01

The long-term radiation risks are believed to be heavily affected by the resuspension process. We therefore focus on the surface-atmosphere exchange process of released radioactive materials in this study. Radioactive materials were deposited on the soil and float in the air, and such complicated process are influenced by the weather conditions deeply. We need to reveal the correlation between the weather conditions and the ambient dose rate. In this study, we study the correlation between the weather conditions and the ambient dose rate with the correction of the decrease due to the radioactive decay. We found that there is a negative correlation between the ambient dose rate and the soil water content by the correlation coefficient. Using this result, we reconstruct the ambient dose rate from the weather conditions by the multiple regression analysis and found that the reconstructed data agree with the observation very well. Using Kalman filter, which can be sequentially updates the state estimate, we obtained such a good agreement.

Decreased integration and information capacity in stroke measured by whole brain models of resting state activity.

Science.gov (United States)

Adhikari, Mohit H; Hacker, Carl D; Siegel, Josh S; Griffa, Alessandra; Hagmann, Patric; Deco, Gustavo; Corbetta, Maurizio

2017-04-01

While several studies have shown that focal lesions affect the communication between structurally normal regions of the brain, and that these changes may correlate with behavioural deficits, their impact on brain's information processing capacity is currently unknown. Here we test the hypothesis that focal lesions decrease the brain's information processing capacity, of which changes in functional connectivity may be a measurable correlate. To measure processing capacity, we turned to whole brain computational modelling to estimate the integration and segregation of information in brain networks. First, we measured functional connectivity between different brain areas with resting state functional magnetic resonance imaging in healthy subjects (n = 26), and subjects who had suffered a cortical stroke (n = 36). We then used a whole-brain network model that coupled average excitatory activities of local regions via anatomical connectivity. Model parameters were optimized in each healthy or stroke participant to maximize correlation between model and empirical functional connectivity, so that the model's effective connectivity was a veridical representation of healthy or lesioned brain networks. Subsequently, we calculated two model-based measures: 'integration', a graph theoretical measure obtained from functional connectivity, which measures the connectedness of brain networks, and 'information capacity', an information theoretical measure that cannot be obtained empirically, representative of the segregative ability of brain networks to encode distinct stimuli. We found that both measures were decreased in stroke patients, as compared to healthy controls, particularly at the level of resting-state networks. Furthermore, we found that these measures, especially information capacity, correlate with measures of behavioural impairment and the segregation of resting-state networks empirically measured. This study shows that focal lesions affect the brain's ability to

Cluster-cluster correlations and constraints on the correlation hierarchy

Science.gov (United States)

Hamilton, A. J. S.; Gott, J. R., III

1988-01-01

The hypothesis that galaxies cluster around clusters at least as strongly as they cluster around galaxies imposes constraints on the hierarchy of correlation amplitudes in hierachical clustering models. The distributions which saturate these constraints are the Rayleigh-Levy random walk fractals proposed by Mandelbrot; for these fractal distributions cluster-cluster correlations are all identically equal to galaxy-galaxy correlations. If correlation amplitudes exceed the constraints, as is observed, then cluster-cluster correlations must exceed galaxy-galaxy correlations, as is observed.

Increase in salivary oxytocin and decrease in salivary cortisol after listening to relaxing slow-tempo and exciting fast-tempo music.

Directory of Open Access Journals (Sweden)

Yuuki Ooishi

Full Text Available Relaxation and excitation are components of the effects of music listening. The tempo of music is often considered a critical factor when determining these effects: listening to slow-tempo and fast-tempo music elicits relaxation and excitation, respectively. However, the chemical bases that underlie these relaxation and excitation effects remain unclear. Since parasympathetic and sympathetic nerve activities are facilitated by oxytocin and glucocorticoid, respectively, we hypothesized that listening to relaxing slow-tempo and exciting fast-tempo music is accompanied by increases in the oxytocin and cortisol levels, respectively. We evaluated the change in the salivary oxytocin and cortisol levels of participants listening to slow-tempo and fast-tempo music sequences. We measured the heart rate (HR and calculated the heart rate variability (HRV to evaluate the strength of autonomic nerve activity. After listening to a music sequence, the participants rated their arousal and valence levels. We found that both the salivary oxytocin concentration and the high frequency component of the HRV (HF increased and the HR decreased when a slow-tempo music sequence was presented. The salivary cortisol level decreased and the low frequency of the HRV (LF to HF ratio (LF/HF increased when a fast-tempo music sequence was presented. The ratio of the change in the oxytocin level was correlated with the change in HF, LF/HF and HR, whereas that in the cortisol level did not show any correlation with indices of autonomic nerve activity. There was no correlation between the change in oxytocin level and self-reported emotions, while the change in cortisol level correlated with the arousal level. These findings suggest that listening to slow-tempo and fast-tempo music is accompanied by an increase in the oxytocin level and a decrease in the cortisol level, respectively, and imply that such music listening-related changes in oxytocin and cortisol are involved in

Increase in salivary oxytocin and decrease in salivary cortisol after listening to relaxing slow-tempo and exciting fast-tempo music

Science.gov (United States)

Watanabe, Ken; Kawato, Suguru; Kashino, Makio

2017-01-01

Relaxation and excitation are components of the effects of music listening. The tempo of music is often considered a critical factor when determining these effects: listening to slow-tempo and fast-tempo music elicits relaxation and excitation, respectively. However, the chemical bases that underlie these relaxation and excitation effects remain unclear. Since parasympathetic and sympathetic nerve activities are facilitated by oxytocin and glucocorticoid, respectively, we hypothesized that listening to relaxing slow-tempo and exciting fast-tempo music is accompanied by increases in the oxytocin and cortisol levels, respectively. We evaluated the change in the salivary oxytocin and cortisol levels of participants listening to slow-tempo and fast-tempo music sequences. We measured the heart rate (HR) and calculated the heart rate variability (HRV) to evaluate the strength of autonomic nerve activity. After listening to a music sequence, the participants rated their arousal and valence levels. We found that both the salivary oxytocin concentration and the high frequency component of the HRV (HF) increased and the HR decreased when a slow-tempo music sequence was presented. The salivary cortisol level decreased and the low frequency of the HRV (LF) to HF ratio (LF/HF) increased when a fast-tempo music sequence was presented. The ratio of the change in the oxytocin level was correlated with the change in HF, LF/HF and HR, whereas that in the cortisol level did not show any correlation with indices of autonomic nerve activity. There was no correlation between the change in oxytocin level and self-reported emotions, while the change in cortisol level correlated with the arousal level. These findings suggest that listening to slow-tempo and fast-tempo music is accompanied by an increase in the oxytocin level and a decrease in the cortisol level, respectively, and imply that such music listening-related changes in oxytocin and cortisol are involved in physiological

Increase in salivary oxytocin and decrease in salivary cortisol after listening to relaxing slow-tempo and exciting fast-tempo music.

Science.gov (United States)

Ooishi, Yuuki; Mukai, Hideo; Watanabe, Ken; Kawato, Suguru; Kashino, Makio

2017-01-01

Relaxation and excitation are components of the effects of music listening. The tempo of music is often considered a critical factor when determining these effects: listening to slow-tempo and fast-tempo music elicits relaxation and excitation, respectively. However, the chemical bases that underlie these relaxation and excitation effects remain unclear. Since parasympathetic and sympathetic nerve activities are facilitated by oxytocin and glucocorticoid, respectively, we hypothesized that listening to relaxing slow-tempo and exciting fast-tempo music is accompanied by increases in the oxytocin and cortisol levels, respectively. We evaluated the change in the salivary oxytocin and cortisol levels of participants listening to slow-tempo and fast-tempo music sequences. We measured the heart rate (HR) and calculated the heart rate variability (HRV) to evaluate the strength of autonomic nerve activity. After listening to a music sequence, the participants rated their arousal and valence levels. We found that both the salivary oxytocin concentration and the high frequency component of the HRV (HF) increased and the HR decreased when a slow-tempo music sequence was presented. The salivary cortisol level decreased and the low frequency of the HRV (LF) to HF ratio (LF/HF) increased when a fast-tempo music sequence was presented. The ratio of the change in the oxytocin level was correlated with the change in HF, LF/HF and HR, whereas that in the cortisol level did not show any correlation with indices of autonomic nerve activity. There was no correlation between the change in oxytocin level and self-reported emotions, while the change in cortisol level correlated with the arousal level. These findings suggest that listening to slow-tempo and fast-tempo music is accompanied by an increase in the oxytocin level and a decrease in the cortisol level, respectively, and imply that such music listening-related changes in oxytocin and cortisol are involved in physiological

Dopaminreceptorscintigraphy in Parkinson's disease - Clinical correlation

International Nuclear Information System (INIS)

Riklund Aahlstroem, K.E.; Hietala, S.-O.; Johansson, F.

2002-01-01

Parkinson's disease is a severe, progressive neuro degenerative disorder which is characterised by a degeneration of the dopamine containing cells and loss of dopamine transporters (DA) in substantia nigra. Earlier 123 I-β-CIT SPECT studies have demonstrated this loss of DA content in Parkinson's disease. Recently a new radioligand 123 I-FP-CIT, with faster kinetics than b-CIT became available for imaging of the DA transporter. The applicability of this radioligand was tested in a large clinical material with early and advanced Parkinson's disease using a one day protocol. 123 I-FP-CIT uptake was decreased in patients with Parkinson's disease and this was seen three hours after injection of the radioligand. In the Parkinson's disease group the uptake in the putamen was reduced more than in the caudate nucleus. Specific to non-specific striatal uptake ratios correlated with the Hoehn and Yahr stage. It appeared that 123 I-FP-CIT SPECT allows a significant discrimination between patients with Parkinson's disease and other movement disorders. The scintigraphic observations were correlated to clinical findings. The results will be presented and discussed

Correlation in stimulated respiratory neural noise

Science.gov (United States)

Hoop, Bernard; Burton, Melvin D.; Kazemi, Homayoun; Liebovitch, Larry S.

1995-09-01

Noise in spontaneous respiratory neural activity of the neonatal rat isolated brainstem-spinal cord preparation stimulated with acetylcholine (ACh) exhibits positive correlation. Neural activity from the C4 (phrenic) ventral spinal rootlet, integrated and corrected for slowly changing trend, is interpreted as a fractal record in time by rescaled range, relative dispersional, and power spectral analyses. The Hurst exponent H measured from time series of 64 consecutive signal levels recorded at 2 s intervals during perfusion of the preparation with artificial cerebrospinal fluid containing ACh at concentrations 62.5 to 1000 μM increases to a maximum of 0.875±0.087 (SD) at 250 μM ACh and decreases with higher ACh concentration. Corrections for bias in measurement of H were made using two different kinds of simulated fractional Gaussian noise. Within limits of experimental procedure and short data series, we conclude that in the presence of added ACh of concentration 250 to 500 μM, noise which occurs in spontaneous respiratory-related neural activity in the isolated brainstem-spinal cord preparation observed at uniform time intervals exhibits positive correlation.

Spin-density correlations in the dynamic spin-fluctuation theory: Comparison with polarized neutron scattering experiments

Energy Technology Data Exchange (ETDEWEB)

Melnikov, N.B., E-mail: melnikov@cs.msu.su [Lomonosov Moscow State University, Moscow 119991 (Russian Federation); Reser, B.I., E-mail: reser@imp.uran.ru [Miheev Institute of Metal Physics, Ural Branch of Russian Academy of Sciences, Ekaterinburg 620990 (Russian Federation); Paradezhenko, G.V., E-mail: gparadezhenko@cs.msu.su [Lomonosov Moscow State University, Moscow 119991 (Russian Federation)

2016-08-01

To study the spin-density correlations in the ferromagnetic metals above the Curie temperature, we relate the spin correlator and neutron scattering cross-section. In the dynamic spin-fluctuation theory, we obtain explicit expressions for the effective and local magnetic moments and spatial spin-density correlator. Our theoretical results are demonstrated by the example of bcc Fe. The effective and local moments are found in good agreement with results of polarized neutron scattering experiment over a wide temperature range. The calculated short-range order is small (up to 4 Å) and slowly decreases with temperature.

High-latitude Conic Current Sheets in the Solar Wind

Energy Technology Data Exchange (ETDEWEB)

Khabarova, Olga V.; Obridko, Vladimir N.; Kharshiladze, Alexander F. [Pushkov Institute of Terrestrial Magnetism, Ionosphere and Radio Wave Propagation of the Russian Academy of Sciences (IZMIRAN), Moscow (Russian Federation); Malova, Helmi V. [Scobeltsyn Nuclear Physics Institute of Lomonosov Moscow State University, Moscow (Russian Federation); Kislov, Roman A.; Zelenyi, Lev M. [Space Research Centre of the Polish Academy of Sciences (CBK PAN), Warsaw (Poland); Tokumaru, Munetoshi; Fujiki, Ken’ichi [Institute for Space-Earth Environmental Research, Nagoya University (Japan); Sokół, Justyna M.; Grzedzielski, Stan [Space Research Centre of the Polish Academy of Sciences (CBK), Warsaw (Poland)

2017-02-10

We provide observational evidence for the existence of large-scale cylindrical (or conic-like) current sheets (CCSs) at high heliolatitudes. Long-lived CCSs were detected by Ulysses during its passages over the South Solar Pole in 1994 and 2007. The characteristic scale of these tornado-like structures is several times less than a typical width of coronal holes within which the CCSs are observed. CCS crossings are characterized by a dramatic decrease in the solar wind speed and plasma beta typical for predicted profiles of CCSs. Ulysses crossed the same CCS at different heliolatitudes at 2–3 au several times in 1994, as the CCS was declined from the rotation axis and corotated with the Sun. In 2007, a CCS was detected directly over the South Pole, and its structure was strongly highlighted by the interaction with comet McNaught. Restorations of solar coronal magnetic field lines reveal the occurrence of conic-like magnetic separators over the solar poles in both 1994 and 2007. Such separators exist only during solar minima. Interplanetary scintillation data analysis confirms the presence of long-lived low-speed regions surrounded by the typical polar high-speed solar wind in solar minima. Energetic particle flux enhancements up to several MeV/ nuc are observed at edges of the CCSs. We built simple MHD models of a CCS to illustrate its key features. The CCSs may be formed as a result of nonaxiality of the solar rotation axis and magnetic axis, as predicted by the Fisk–Parker hybrid heliospheric magnetic field model in the modification of Burger and coworkers.

Charged kaon femtoscopic correlations in pp collisions at $\\sqrt{s}=7$ TeV

CERN Document Server

Abelev, B; Adamova, D; Adare, A M; Aggarwal, M M; Aglieri Rinella, G; Agnello, M; Agocs, A G; Agostinelli, A; Ahammed, Z; Ahmad, N; Ahmad Masoodi, A; Ahn, S U; Ahn, S A; Ajaz, M; Akindinov, A; Aleksandrov, D; Alessandro, B; Alici, A; Alkin, A; Almaraz Avina, E; Alme, J; Alt, T; Altini, V; Altinpinar, S; Altsybeev, I; Andrei, C; Andronic, A; Anguelov, V; Anielski, J; Anson, C; Anticic, T; Antinori, F; Antonioli, P; Aphecetche, L; Appelshauser, H; Arbor, N; Arcelli, S; Arend, A; Armesto, N; Arnaldi, R; Aronsson, T; Arsene, I C; Arslandok, M; Asryan, A; Augustinus, A; Averbeck, R; Awes, T C; Aysto, J; Azmi, M D; Bach, M; Badala, A; Baek, Y W; Bailhache, R; Bala, R; Baldini Ferroli, R.; Baldisseri, A; Baltasar Dos Santos Pedrosa, F; Ban, J; Baral, R C; Barbera, R; Barile, F; Barnafoldi, G G; Barnby, L S; Barret, V; Bartke, J; Basile, M; Bastid, N; Basu, S; Bathen, B; Batigne, G; Batyunya, B; Baumann, C; Bearden, I G; Beck, H; Behera, N K; Belikov, I; Bellini, F; Bellwied, R; Belmont-Moreno, E; Bencedi, G; Beole, S; Berceanu, I; Bercuci, A; Berdnikov, Y; Berenyi, D; Bergognon, A A E; Berzano, D; Betev, L; Bhasin, A; Bhati, A K; Bhom, J; Bianchi, L; Bianchi, N; Bielcik, J; Bielcikova, J; Bilandzic, A; Bjelogrlic, S; Blanco, F; Blanco, F; Blau, D; Blume, C; Boccioli, M; Bottger, S; Bogdanov, A; Boggild, H; Bogolyubsky, M; Boldizsar, L; Bombara, M; Book, J; Borel, H; Borissov, A; Bossu, F; Botje, M; Botta, E; Braidot, E; Braun-Munzinger, P; Bregant, M; Breitner, T; Browning, T A; Broz, M; Brun, R; Bruna, E; Bruno, G E; Budnikov, D; Buesching, H; Bufalino, S; Buncic, P; Busch, O; Buthelezi, Z; Caballero Orduna, D.; Caffarri, D; Cai, X; Caines, H; Calvo Villar, E; Camerini, P; Canoa Roman, V; Cara Romeo, G; Carena, F; Carena, W; Carlin Filho, N; Carminati, F; Casanova Diaz, A; Castillo Castellanos, J; Castillo Hernandez, J F; Casula, E A R; Catanescu, V; Cavicchioli, C; Ceballos Sanchez, C; Cepila, J; Cerello, P; Chang, B; Chapeland, S; Charvet, J L; Chattopadhyay, S; Chattopadhyay, S; Chawla, I; Cherney, M; Cheshkov, C; Cheynis, B; Chibante Barroso, V; Chinellato, D D; Chochula, P; Chojnacki, M; Choudhury, S; Christakoglou, P; Christensen, C H; Christiansen, P; Chujo, T; Chung, S U; Cicalo, C; Cifarelli, L; Cindolo, F; Cleymans, J; Coccetti, F; Colamaria, F; Colella, D; Collu, A; Conesa Balbastre, G; Conesa del Valle, Z; Connors, M E; Contin, G; Contreras, J G; Cormier, T M; Corrales Morales, Y; Cortese, P; Cortes Maldonado, I; Cosentino, M R; Costa, F; Cotallo, M E; Crescio, E; Crochet, P; Cruz Alaniz, E; Cuautle, E; Cunqueiro, L; Dainese, A; Dalsgaard, H H; Danu, A; Das, S; Das, I; Das, D; Das, K; Dash, A; Dash, S; De, S; de Barros, G O V; De Caro, A; De Cataldo, G; de Cuveland, J; De Falco, A; De Gruttola, D; Delagrange, H; Deloff, A; De Marco, N; Denes, E; De Pasquale, S; Deppman, A; D'Erasmo, G; de Rooij, R; Diaz Corchero, M A; Di Bari, D; Dietel, T; Di Giglio, C; Di Liberto, S; Di Mauro, A; Di Nezza, P; Divia, R; Djuvsland, O; Dobrin, A; Dobrowolski, T; Donigus, B; Dordic, O; Driga, O; Dubey, A K; Dubla, A; Ducroux, L; Dupieux, P; Dutta Majumdar, A K; Dutta Majumdar, M R; Elia, D; Emschermann, D; Engel, H; Erazmus, B; Erdal, H A; Espagnon, B; Estienne, M; Esumi, S; Evans, D; Eyyubova, G; Fabris, D; Faivre, J; Falchieri, D; Fantoni, A; Fasel, M; Fearick, R; Fehlker, D; Feldkamp, L; Felea, D; Feliciello, A; Fenton-Olsen, B; Feofilov, G; Fernandez Tellez, A; Ferretti, A; Festanti, A; Figiel, J; Figueredo, M A S; Filchagin, S; Finogeev, D; Fionda, F M; Fiore, E M; Floratos, E; Floris, M; Foertsch, S; Foka, P; Fokin, S; Fragiacomo, E; Francescon, A; Frankenfeld, U; Fuchs, U; Furget, C; Fusco Girard, M; Gaardhoje, J J; Gagliardi, M; Gago, A; Gallio, M; Gangadharan, D R; Ganoti, P; Garabatos, C; Garcia-Solis, E; Garishvili, I; Gerhard, J; Germain, M; Geuna, C; Gheata, M; Gheata, A; Ghosh, P; Gianotti, P; Girard, M R; Giubellino, P; Gladysz-Dziadus, E; Glassel, P; Gomez, R; Ferreiro, E G; Gonzalez-Trueba, L H; Gonzalez-Zamora, P; Gorbunov, S; Goswami, A; Gotovac, S; Graczykowski, L K; Grajcarek, R; Grelli, A; Grigoras, C; Grigoras, A; Grigoriev, V; Grigoryan, S; Grigoryan, A; Grinyov, B; Grion, N; Gros, P; Grosse-Oetringhaus, J F; Grossiord, J Y; Grosso, R; Guber, F; Guernane, R; Guerzoni, B; Guilbaud, M; Gulbrandsen, K; Gulkanyan, H; Gunji, T; Gupta, A; Gupta, R; Haaland, O; Hadjidakis, C; Haiduc, M; Hamagaki, H; Hamar, G; Han, B H; Hanratty, L D; Hansen, A; Harmanova-Tothova, Z; Harris, J W; Hartig, M; Harton, A; Hasegan, D; Hatzifotiadou, D; Hayashi, S; Hayrapetyan, A; Heckel, S T; Heide, M; Helstrup, H; Herghelegiu, A; Herrera Corral, G; Herrmann, N; Hess, B A; Hetland, K F; Hicks, B; Hippolyte, B; Hori, Y; Hristov, P; Hrivnacova, I; Huang, M; Humanic, T J; Hwang, D S; Ichou, R; Ilkaev, R; Ilkiv, I; Inaba, M; Incani, E; Innocenti, G M; Innocenti, P G; Ippolitov, M; Irfan, M; Ivan, C; Ivanov, V; Ivanov, A; Ivanov, M; Ivanytskyi, O; Jacholkowski, A; Jacobs, P M; Jang, H J; Janik, M A; Janik, R; Jayarathna, P.H S Y; Jena, S; Jha, D M; Jimenez Bustamante, R T; Jones, P G; Jung, H; Jusko, A; Kaidalov, A B; Kalcher, S; Kalinak, P; Kalliokoski, T; Kalweit, A; Kang, J H; Kaplin, V; Karasu Uysal, A; Karavichev, O; Karavicheva, T; Karpechev, E; Kazantsev, A; Kebschull, U; Keidel, R; Khan, M M; Khan, P; Khan, K H; Khan, S A; Khanzadeev, A; Kharlov, Y; Kileng, B; Kim, S; Kim, M; Kim, M; Kim, J S; Kim, J H; Kim, D W; Kim, B; Kim, D J; Kim, T; Kirsch, S; Kisel, I; Kiselev, S; Kisiel, A; Klay, J L; Klein, J; Klein-Bosing, C; Kliemant, M; Kluge, A; Knichel, M L; Knospe, A G; Kohler, M K; Kollegger, T; Kolojvari, A; Kompaniets, M; Kondratiev, V; Kondratyeva, N; Konevskikh, A; Kour, R; Kovalenko, V; Kowalski, M; Kox, S; Koyithatta Meethaleveedu, G; Kral, J; Kralik, I; Kramer, F; Kravcakova, A; Krawutschke, T; Krelina, M; Kretz, M; Krivda, M; Krizek, F; Krus, M; Kryshen, E; Krzewicki, M; Kucheriaev, Y; Kugathasan, T; Kuhn, C; Kuijer, P G; Kulakov, I; Kumar, J; Kurashvili, P; Kurepin, A B; Kurepin, A; Kuryakin, A; Kushpil, V; Kushpil, S; Kvaerno, H; Kweon, M J; Kwon, Y; Ladron de Guevara, P; Lakomov, I; Langoy, R; La Pointe, S L; Lara, C; Lardeux, A; La Rocca, P; Lea, R; Lechman, M; Lee, G R; Lee, K S; Lee, S C; Legrand, I; Lehnert, J; Lenhardt, M; Lenti, V; Leon, H; Leon Monzon, I; Leon Vargas, H; Levai, P; Li, S; Lien, J; Lietava, R; Lindal, S; Lindenstruth, V; Lippmann, C; Lisa, M A; Ljunggren, H M; Loenne, P I; Loggins, V R; Loginov, V; Lohner, D; Loizides, C; Loo, K K; Lopez, X; Lopez Torres, E; Lovhoiden, G; Lu, X G; Luettig, P; Lunardon, M; Luo, J; Luparello, G; Luzzi, C; Ma, K; Ma, R; Madagodahettige-Don, D M; Maevskaya, A; Mager, M; Mahapatra, D P; Maire, A; Malaev, M; Maldonado Cervantes, I; Malinina, L; Mal'Kevich, D; Malzacher, P; Mamonov, A; Manceau, L; Mangotra, L; Manko, V; Manso, F; Manzari, V; Mao, Y; Marchisone, M; Mares, J; Margagliotti, G V; Margotti, A; Marin, A; Markert, C; Marquard, M; Martashvili, I; Martin, N A; Martinengo, P; Martinez, M I; Martinez Davalos, A; Martinez Garcia, G; Martynov, Y; Mas, A; Masciocchi, S; Masera, M; Masoni, A; Massacrier, L; Mastroserio, A; Matthews, Z L; Matyja, A; Mayer, C; Mazer, J; Mazzoni, M A; Meddi, F; Menchaca-Rocha, A; Mercado Perez, J; Meres, M; Miake, Y; Mikhailov, K; Milano, L; Milosevic, J; Mischke, A; Mishra, A N; Miskowiec, D; Mitu, C; Mizuno, S; Mlynarz, J; Mohanty, B; Molnar, L; Montano Zetina, L; Monteno, M; Montes, E; Moon, T; Morando, M; Moreira De Godoy, D A; Moretto, S; Morreale, A; Morsch, A; Muccifora, V; Mudnic, E; Muhuri, S; Mukherjee, M; Muller, H; Munhoz, M G; Musa, L; Musinsky, J; Musso, A; Nandi, B K; Nania, R; Nappi, E; Nattrass, C; Navin, S; Nayak, T K; Nazarenko, S; Nedosekin, A; Nicassio, M; Niculescu, M; Nielsen, B S; Niida, T; Nikolaev, S; Nikolic, V; Nikulin, S; Nikulin, V; Nilsen, B S; Nilsson, M S; Noferini, F; Nomokonov, P; Nooren, G; Novitzky, N; Nyanin, A; Nyatha, A; Nygaard, C; Nystrand, J; Ochirov, A; Oeschler, H; Oh, S K; Oh, S; Oleniacz, J; Oliveira Da Silva, A C; Oppedisano, C; Ortiz Velasquez, A; Oskarsson, A; 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Ramello, L; Ramirez Reyes, A; Raniwala, R; Raniwala, S; Rasanen, S S; Rascanu, B T; Rathee, D; Read, K F; Real, J S; Redlich, K; Reed, R J; Rehman, A; Reichelt, P; Reicher, M; Renfordt, R; Reolon, A R; Reshetin, A; Rettig, F; Revol, J P; Reygers, K; Riccati, L; Ricci, R A; Richert, T; Richter, M; Riedler, P; Riegler, W; Riggi, F; Rodriguez Cahuantzi, M; Rodriguez Manso, A; Roed, K; Rohr, D; Rohrich, D; Romita, R; Ronchetti, F; Rosnet, P; Rossegger, S; Rossi, A; Roy, P; Roy, C; Rubio Montero, A J; Rui, R; Russo, R; Ryabinkin, E; Rybicki, A; Sadovsky, S; Safarik, K; Sahoo, R; Sahu, P K; Saini, J; Sakaguchi, H; Sakai, S; Sakata, D; Salgado, C A; Salzwedel, J; Sambyal, S; Samsonov, V; Sanchez Castro, X; Sandor, L; Sandoval, A; Sano, M; Santagati, G; Santoro, R; Sarkamo, J; Scapparone, E; Scarlassara, F; Scharenberg, R P; Schiaua, C; Schicker, R; Schmidt, H R; Schmidt, C; Schuchmann, S; Schukraft, J; Schuster, T; Schutz, Y; Schwarz, K; Schweda, K; Scioli, G; Scomparin, E; Scott, P A; Scott, R; 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Yamaguchi, Y; Yang, H; Yang, S; Yasnopolskiy, S; Yi, J; Yin, Z; Yoo, I K; Yoon, J; Yu, W; Yuan, X; Yushmanov, I; Zaccolo, V; Zach, C; Zampolli, C; Zaporozhets, S; Zarochentsev, A; Zavada, P; Zaviyalov, N; Zbroszczyk, H; Zelnicek, P; Zgura, I S; Zhalov, M; Zhang, H; Zhang, X; Zhou, D; Zhou, Y; Zhou, F; Zhu, J; Zhu, H; Zhu, J; Zhu, X; Zichichi, A; Zimmermann, A; Zinovjev, G; Zoccarato, Y; Zynovyev, M; Zyzak, M

2013-01-01

Correlations of two charged identical kaons (K$^{ch}$ K$^{ch}$) are measured in pp collisions at $\\sqrt{s}$=7 TeV by the ALICE experiment at the Large Hadron Collider (LHC). One-dimensional K$^{ch}$ K$^{ch}$ correlation functions are constructed in three multiplicity and four transverse momentum ranges. The K$^{ch}$ K$^{ch}$ femtoscopic source parameters R and lambda are extracted. The K$^{ch}$ K$^{ch}$ correlations show a slight increase of femtoscopic radii with increasing multiplicity and a slight decrease of radii with increasing transverse momentum. These trends are similar to the ones observed for $\\pi\\pi$ and $K_s^0 K_s^0$ correlations in pp and heavy-ion collisions. However, the observed one dimensional correlation radii for charged kaons are larger at high multiplicities than those for pions in contrast to what was observed in heavy-ion collisions at RHIC.

Decreased serum level of HMGB1 and MyD88 during human aging progress in healthy individuals.

Science.gov (United States)

Fu, Guo-Xiang; Chen, Alex F; Zhong, Yuan; Zhao, Jian; Gu, Ying-Jia

2016-04-01

Previous studies have suggested that high mobility group box-1 protein (HMGB1) binds to the toll-like receptor 4 (TLR4) signaling mediates the progression of various inflammatory diseases. But the roles of HMGB1 and TLR4 in aging remain poorly unknown. In this study, we aimed to investigate the serum levels of HMGB1 and myeloid differentiation factor 88 (MyD88), which is one of TLR4's intracellular adaptor proteins during human aging process and their relevance with cathepsin B (CTSB). This research was conducted using the blood samples provided by healthy people (n = 90, 63 men and 27 women). Subjects were subdivided into groups with respect to age: young (about 25 years old, n = 30), middle age (about 40 years old, n = 30), and aged (above 65 years old, n = 30). Altered serum levels of HMGB1, MyD88 and CTSB were measured using an enzyme-linked immunosorbent assay. The serum levels of HMGB1 and MyD88 were significantly decreased in the aged group compared with those in the young group. Linear regression analysis showed that HMGB1 and MyD88 positively correlated with CTSB among the whole healthy people. A negative correlation was determined between MyD88 and age. The serum levels of HMGB1 and MyD88 significantly decreased with age. MyD88, but not HMGB1, was negatively correlated with age.

Decrease of NAA with aging outside the seizure focus in mesial temporal lobe epilepsy--a proton-MRS study at 3 Tesla.

Science.gov (United States)

Riederer, Franz; Bittsanský, Michal; Lehner-Baumgartner, Eva; Baumgartner, Christoph; Mlynárik, Vladimír; Gruber, Stephan; Moser, Ewald; Kaya, Marihan; Serles, Wolfgang

2007-11-07

There is evidence that chronic pharmacoresistant temporal lobe epilepsy (TLE) is a progressive disorder accompanied by mental deterioration. We investigated effects of aging on cerebral N-acetyl-aspartate (NAA) concentrations in the temporal lobe of 12 patients with pharmacoresistant mesial TLE (mTLE) and 22 healthy controls by means of proton-magnetic resonance spectroscopy ((1)H-MRS) at 3 T. Furthermore, we calculated correlations between NAA concentrations and measures of verbal and figural memory in patients. In mTLE patients but not in healthy controls the concentration of NAA in the lateral temporal lobe was negatively correlated with age. In patients with mTLE NAA in left lateral temporal voxels correlated with verbal memory. NAA in medial temporal voxels did not correlate with age or neuropsychological measures. Significant decrease of NAA with age in the lateral temporal lobe of patients with mTLE provides evidence for progressive neuronal dysfunction with aging. NAA is a marker of neuronal integrity since it correlates with verbal memory.

A statistical model for estimation of fish density including correlation in size, space, time and between species from research survey data.

Directory of Open Access Journals (Sweden)

J Rasmus Nielsen

Full Text Available Trawl survey data with high spatial and seasonal coverage were analysed using a variant of the Log Gaussian Cox Process (LGCP statistical model to estimate unbiased relative fish densities. The model estimates correlations between observations according to time, space, and fish size and includes zero observations and over-dispersion. The model utilises the fact the correlation between numbers of fish caught increases when the distance in space and time between the fish decreases, and the correlation between size groups in a haul increases when the difference in size decreases. Here the model is extended in two ways. Instead of assuming a natural scale size correlation, the model is further developed to allow for a transformed length scale. Furthermore, in the present application, the spatial- and size-dependent correlation between species was included. For cod (Gadus morhua and whiting (Merlangius merlangus, a common structured size correlation was fitted, and a separable structure between the time and space-size correlation was found for each species, whereas more complex structures were required to describe the correlation between species (and space-size. The within-species time correlation is strong, whereas the correlations between the species are weaker over time but strong within the year.

Correlations of light particles with the INDRA 4{pi} detector; Correlations de particules legeres avec le detector 4{pi} INDRA

Energy Technology Data Exchange (ETDEWEB)

Gourio, D.; Ardouin, D.; Reposeur, T.; Assenard, M.; Eudes, P.; Germain, M.; Lautridou, P.; Laville, J.L.; Lebrun, C.; Metivier, V.; Rahmani, A. [Laboratoire de Physique Subatomique et des Technologies Associees - SUBATECH, Centre National de la Recherche Scientifique, 44 - Nantes (France); INDRA Collaboration

1997-10-01

Light particle correlation functions have been measured with the INDRA multidetector. For the first time the study has been done using a 4 {pi} as a correlator and as an event filter. The combination of these two tools in the field of interferometry, is used for the first time here for the determination of the emission mean time of the light particles. The analysis was concentrated on the Xe + Sn system at 45 and 50 MeV/A. Due to the global event-by-event analysis it was possible to assign the origin of the particles to three emission zones: quasi-projectile, quasi-target and the intermediate zone. INDRA has also permitted to select the collision violence by using the total transverse energy of the light particles. The analysis of the proton-deuteron and deuteron-deuteron correlations indicates a decrease of the emission time with the increase of excitation energy. However in average the deuterons are emitted prior to the protons. Sequential decay of the excited fragments occurred in the additional structures at low relative momenta in the case of the proton-proton and proton-deuteron functions. These structures are evidenced particularly due to the adopted selections 3 refs.

Wavelet Correlation Coefficient of 'strongly correlated' financial time series

OpenAIRE

Razdan, Ashok

2003-01-01

In this paper we use wavelet concepts to show that correlation coefficient between two financial data's is not constant but varies with scale from high correlation value to strongly anti-correlation value This studies is important because correlation coefficient is used to quantify degree of independence between two variables. In econophysics correlation coefficient forms important input to evolve hierarchial tree and minimum spanning tree of financial data.

Methamphetamine decreases dentate gyrus stem cell self-renewal and shifts the differentiation towards neuronal fate

Directory of Open Access Journals (Sweden)

Sofia Baptista

2014-09-01

Full Text Available Methamphetamine (METH is a highly addictive psychostimulant drug of abuse that negatively interferes with neurogenesis. In fact, we have previously shown that METH triggers stem/progenitor cell death and decreases neuronal differentiation in the dentate gyrus (DG. Still, little is known regarding its effect on DG stem cell properties. Herein, we investigate the impact of METH on mice DG stem/progenitor cell self-renewal functions. METH (10 nM decreased DG stem cell self-renewal, while 1 nM delayed cell cycle in the G0/G1-to-S phase transition and increased the number of quiescent cells (G0 phase, which correlated with a decrease in cyclin E, pEGFR and pERK1/2 protein levels. Importantly, both drug concentrations (1 or 10 nM did not induce cell death. In accordance with the impairment of self-renewal capacity, METH (10 nM decreased Sox2+/Sox2+ while increased Sox2−/Sox2− pairs of daughter cells. This effect relied on N-methyl-d-aspartate (NMDA signaling, which was prevented by the NMDA receptor antagonist, MK-801 (10 μM. Moreover, METH (10 nM increased doublecortin (DCX protein levels consistent with neuronal differentiation. In conclusion, METH alters DG stem cell properties by delaying cell cycle and decreasing self-renewal capacities, mechanisms that may contribute to DG neurogenesis impairment followed by cognitive deficits verified in METH consumers.

Electronic interactions decreasing the activation barrier for the hydrogen electro-oxidation reaction

International Nuclear Information System (INIS)

Santos, Elizabeth; Schmickler, Wolfgang

2008-01-01

A unified model for electrochemical electron transfer reactions which explicitly accounts for the electronic structure of the electrode recently proposed by us is applied to the hydrogen oxidation reaction at different metal electrocatalysts. We focus on the changes produced in the transition state (saddle point) as a consequence of the interactions with d-bands. We discuss different empirical correlations between properties of the metal and catalytic activity proposed in the past. We show which role is played by the band structure of the different metals and its interaction with the molecule for decreasing the activation barrier. Finally, we demonstrate why some metals are better electrocatalysts for the hydrogen electro-oxidation reaction than others

Life history trade-offs and relaxed selection can decrease bacterial virulence in environmental reservoirs.

Directory of Open Access Journals (Sweden)

Lauri Mikonranta

Full Text Available Pathogen virulence is usually thought to evolve in reciprocal selection with the host. While this might be true for obligate pathogens, the life histories of opportunistic pathogens typically alternate between within-host and outside-host environments during the infection-transmission cycle. As a result, opportunistic pathogens are likely to experience conflicting selection pressures across different environments, and this could affect their virulence through life-history trait correlations. We studied these correlations experimentally by exposing an opportunistic bacterial pathogen Serratia marcescens to its natural protist predator Tetrahymena thermophila for 13 weeks, after which we measured changes in bacterial traits related to both anti-predator defence and virulence. We found that anti-predator adaptation (producing predator-resistant biofilm caused a correlative attenuation in virulence. Even though the direct mechanism was not found, reduction in virulence was most clearly connected to a predator-driven loss of a red bacterial pigment, prodigiosin. Moreover, life-history trait evolution was more divergent among replicate populations in the absence of predation, leading also to lowered virulence in some of the 'predator absent' selection lines. Together these findings suggest that the virulence of non-obligatory, opportunistic bacterial pathogens can decrease in environmental reservoirs through life history trade-offs, or random accumulation of mutations that impair virulence traits under relaxed selection.

Early anti-correlated BOLD signal changes of physiologic origin.

Science.gov (United States)

Bright, Molly G; Bianciardi, Marta; de Zwart, Jacco A; Murphy, Kevin; Duyn, Jeff H

2014-02-15

Negative BOLD signals that are synchronous with resting state fluctuations have been observed in large vessels in the cortical sulci and surrounding the ventricles. In this study, we investigated the origin of these negative BOLD signals by applying a Cued Deep Breathing (CDB) task to create transient hypocapnia and a resultant global fMRI signal decrease. We hypothesized that a global stimulus would amplify the effect in large vessels and that using a global negative (vasoconstrictive) stimulus would test whether these voxels exhibit either inherently negative or simply anti-correlated BOLD responses. Significantly anti-correlated, but positive, BOLD signal changes during respiratory challenges were identified in voxels primarily located near edges of brain spaces containing CSF. These positive BOLD responses occurred earlier than the negative CDB response across most of gray matter voxels. These findings confirm earlier suggestions that in some brain regions, local, fractional changes in CSF volume may overwhelm BOLD-related signal changes, leading to signal anti-correlation. We show that regions with CDB anti-correlated signals coincide with most, but not all, of the regions with negative BOLD signal changes observed during a visual and motor stimulus task. Thus, the addition of a physiological challenge to fMRI experiments can help identify which negative BOLD signals are passive physiological anti-correlations and which may have a putative neuronal origin. Published by Elsevier Inc.