WorldWideScience

Sample records for death toll mounts

  1. Uncovering the 2010 Haiti earthquake death toll

    Science.gov (United States)

    Daniell, J. E.; Khazai, B.; Wenzel, F.

    2013-05-01

    Casualties are estimated for the 12 January 2010 earthquake in Haiti using various reports calibrated by observed building damage states from satellite imagery and reconnaissance reports on the ground. By investigating various damage reports, casualty estimates and burial figures, for a one year period from 12 January 2010 until 12 January 2011, there is also strong evidence that the official government figures of 316 000 total dead and missing, reported to have been caused by the earthquake, are significantly overestimated. The authors have examined damage and casualties report to arrive at their estimation that the median death toll is less than half of this value (±137 000). The authors show through a study of historical earthquake death tolls, that overestimates of earthquake death tolls occur in many cases, and is not unique to Haiti. As death toll is one of the key elements for determining the amount of aid and reconstruction funds that will be mobilized, scientific means to estimate death tolls should be applied. Studies of international aid in recent natural disasters reveal that large distributions of aid which do not match the respective needs may cause oversupply of help, aggravate corruption and social disruption rather than reduce them, and lead to distrust within the donor community.

  2. Assembly of Oligomeric Death Domain Complexes during Toll Receptor Signaling*

    OpenAIRE

    Moncrieffe, Martin C.; Grossmann, J. Günter; Gay, Nicholas J.

    2008-01-01

    The Drosophila Toll receptor is activated by the endogenous protein ligand Spätzle in response to microbial stimuli in immunity and spatial cues during embryonic development. Downstream signaling is mediated by the adaptor proteins Tube, the kinase Pelle, and the Drosophila homologue of myeloid differentiation primary response protein (dMyD88). Here we have characterized heterodimeric (dMyD88-Tube) and heterotrimeric (dMyD88-Tube-Pelle) death domain complexes. We show ...

  3. Assembly of Oligomeric Death Domain Complexes during Toll Receptor Signaling*

    Science.gov (United States)

    Moncrieffe, Martin C.; Grossmann, J. Günter; Gay, Nicholas J.

    2008-01-01

    The Drosophila Toll receptor is activated by the endogenous protein ligand Spätzle in response to microbial stimuli in immunity and spatial cues during embryonic development. Downstream signaling is mediated by the adaptor proteins Tube, the kinase Pelle, and the Drosophila homologue of myeloid differentiation primary response protein (dMyD88). Here we have characterized heterodimeric (dMyD88-Tube) and heterotrimeric (dMyD88-Tube-Pelle) death domain complexes. We show that both the heterodimeric and heterotrimeric complexes form kidney-shaped structures and that Tube is bivalent and has separate high affinity binding sites for dMyD88 and Pelle. Additionally we found no interaction between the isolated death domains of Pelle and dMyD88. These results indicate that the mode of assembly of the heterotrimeric dMyD88-Tube-Pelle complex downstream of the activated Toll receptor is unique. The measured dissociation constants for the interaction between the death domains of dMyD88 and Tube and of Pelle and a preformed dMyD88-Tube complex are used to propose a model of the early postreceptor events in Drosophila Toll receptor signaling. PMID:18829464

  4. Assembly of oligomeric death domain complexes during Toll receptor signaling.

    Science.gov (United States)

    Moncrieffe, Martin C; Grossmann, J Günter; Gay, Nicholas J

    2008-11-28

    The Drosophila Toll receptor is activated by the endogenous protein ligand Spätzle in response to microbial stimuli in immunity and spatial cues during embryonic development. Downstream signaling is mediated by the adaptor proteins Tube, the kinase Pelle, and the Drosophila homologue of myeloid differentiation primary response protein (dMyD88). Here we have characterized heterodimeric (dMyD88-Tube) and heterotrimeric (dMyD88-Tube-Pelle) death domain complexes. We show that both the heterodimeric and heterotrimeric complexes form kidney-shaped structures and that Tube is bivalent and has separate high affinity binding sites for dMyD88 and Pelle. Additionally we found no interaction between the isolated death domains of Pelle and dMyD88. These results indicate that the mode of assembly of the heterotrimeric dMyD88-Tube-Pelle complex downstream of the activated Toll receptor is unique. The measured dissociation constants for the interaction between the death domains of dMyD88 and Tube and of Pelle and a preformed dMyD88-Tube complex are used to propose a model of the early postreceptor events in Drosophila Toll receptor signaling.

  5. Correlations and forecast of death tolls in the Syrian conflict.

    Science.gov (United States)

    Fujita, Kazuki; Shinomoto, Shigeru; Rocha, Luis E C

    2017-11-16

    The Syrian armed conflict has been ongoing since 2011 and has already caused thousands of deaths. The analysis of death tolls helps to understand the dynamics of the conflict and to better allocate resources and aid to the affected areas. In this article, we use information on the daily number of deaths to study temporal and spatial correlations in the data, and exploit this information to forecast events of deaths. We found that the number of violent deaths per day in Syria varies more widely than that in England in which non-violent deaths dominate. We have identified strong positive auto-correlations in Syrian cities and non-trivial cross-correlations across some of them. The results indicate synchronization in the number of deaths at different times and locations, suggesting respectively that local attacks are followed by more attacks at subsequent days and that coordinated attacks may also take place across different locations. Thus the analysis of high temporal resolution data across multiple cities makes it possible to infer attack strategies, warn potential occurrence of future events, and hopefully avoid further deaths.

  6. A Method for Estimation of Death Tolls in Disastrous Earthquake

    Science.gov (United States)

    Pai, C.; Tien, Y.; Teng, T.

    2004-12-01

    Fatality tolls caused by the disastrous earthquake are the one of the most important items among the earthquake damage and losses. If we can precisely estimate the potential tolls and distribution of fatality in individual districts as soon as the earthquake occurrences, it not only make emergency programs and disaster management more effective but also supply critical information to plan and manage the disaster and the allotments of disaster rescue manpower and medicine resources in a timely manner. In this study, we intend to reach the estimation of death tolls caused by the Chi-Chi earthquake in individual districts based on the Attributive Database of Victims, population data, digital maps and Geographic Information Systems. In general, there were involved many factors including the characteristics of ground motions, geological conditions, types and usage habits of buildings, distribution of population and social-economic situations etc., all are related to the damage and losses induced by the disastrous earthquake. The density of seismic stations in Taiwan is the greatest in the world at present. In the meantime, it is easy to get complete seismic data by earthquake rapid-reporting systems from the Central Weather Bureau: mostly within about a minute or less after the earthquake happened. Therefore, it becomes possible to estimate death tolls caused by the earthquake in Taiwan based on the preliminary information. Firstly, we form the arithmetic mean of the three components of the Peak Ground Acceleration (PGA) to give the PGA Index for each individual seismic station, according to the mainshock data of the Chi-Chi earthquake. To supply the distribution of Iso-seismic Intensity Contours in any districts and resolve the problems for which there are no seismic station within partial districts through the PGA Index and geographical coordinates in individual seismic station, the Kriging Interpolation Method and the GIS software, The population density depends on

  7. Combined Prediction Model of Death Toll for Road Traffic Accidents Based on Independent and Dependent Variables

    Directory of Open Access Journals (Sweden)

    Feng Zhong-xiang

    2014-01-01

    Full Text Available In order to build a combined model which can meet the variation rule of death toll data for road traffic accidents and can reflect the influence of multiple factors on traffic accidents and improve prediction accuracy for accidents, the Verhulst model was built based on the number of death tolls for road traffic accidents in China from 2002 to 2011; and car ownership, population, GDP, highway freight volume, highway passenger transportation volume, and highway mileage were chosen as the factors to build the death toll multivariate linear regression model. Then the two models were combined to be a combined prediction model which has weight coefficient. Shapley value method was applied to calculate the weight coefficient by assessing contributions. Finally, the combined model was used to recalculate the number of death tolls from 2002 to 2011, and the combined model was compared with the Verhulst and multivariate linear regression models. The results showed that the new model could not only characterize the death toll data characteristics but also quantify the degree of influence to the death toll by each influencing factor and had high accuracy as well as strong practicability.

  8. Combined prediction model of death toll for road traffic accidents based on independent and dependent variables.

    Science.gov (United States)

    Feng, Zhong-xiang; Lu, Shi-sheng; Zhang, Wei-hua; Zhang, Nan-nan

    2014-01-01

    In order to build a combined model which can meet the variation rule of death toll data for road traffic accidents and can reflect the influence of multiple factors on traffic accidents and improve prediction accuracy for accidents, the Verhulst model was built based on the number of death tolls for road traffic accidents in China from 2002 to 2011; and car ownership, population, GDP, highway freight volume, highway passenger transportation volume, and highway mileage were chosen as the factors to build the death toll multivariate linear regression model. Then the two models were combined to be a combined prediction model which has weight coefficient. Shapley value method was applied to calculate the weight coefficient by assessing contributions. Finally, the combined model was used to recalculate the number of death tolls from 2002 to 2011, and the combined model was compared with the Verhulst and multivariate linear regression models. The results showed that the new model could not only characterize the death toll data characteristics but also quantify the degree of influence to the death toll by each influencing factor and had high accuracy as well as strong practicability.

  9. Mangroves protected villages and reduced death toll during Indian super cyclone.

    Science.gov (United States)

    Das, Saudamini; Vincent, Jeffrey R

    2009-05-05

    Protection against coastal disasters has been identified as an important service of mangrove ecosystems. Empirical studies on this service have been criticized, however, for using small samples and inadequately controlling for confounding factors. We used data on several hundred villages to test the impact of mangroves on human deaths during a 1999 super cyclone that struck Orissa, India. We found that villages with wider mangroves between them and the coast experienced significantly fewer deaths than ones with narrower or no mangroves. This finding was robust to the inclusion of a wide range of other variables to our statistical model, including controls for the historical extent of mangroves. Although mangroves evidently saved fewer lives than an early warning issued by the government, the retention of remaining mangroves in Orissa is economically justified even without considering the many benefits they provide to human society besides storm-protection services.

  10. Formation and biochemical characterization of tube/pelle death domain complexes: critical regulators of postreceptor signaling by the Drosophila toll receptor.

    Science.gov (United States)

    Schiffmann, D A; White, J H; Cooper, A; Nutley, M A; Harding, S E; Jumel, K; Solari, R; Ray, K P; Gay, N J

    1999-09-07

    In Drosophila, the Toll receptor signaling pathway is required for embryonic dorso-ventral patterning and at later developmental stages for innate immune responses. It is thought that dimerization of the receptor by binding of the ligand spätzle causes the formation of a postreceptor activation complex at the cytoplasmic surface of the membrane. Two components of this complex are the adaptor tube and protein kinase pelle. These proteins both have "death domains", protein interaction motifs found in a number of signaling pathways, particularly those involved in apoptotic cell death. It is thought that pelle is bound by tube during formation of the activation complexes, and that this interaction is mediated by the death domains. In this paper, we show using the yeast two-hybrid system that the wild-type tube and pelle death domains bind together. Mutant tube proteins which do not support signaling in the embryo are also unable to bind pelle in the 2-hybrid assay. We have purified proteins corresponding to the death domains of tube and pelle and show that these form corresponding heterodimeric complexes in vitro. Partial proteolysis reveals a smaller core consisting of the minimal death domain sequences. We have studied the tube/pelle interaction with the techniques of surface plasmon resonance, analytical ultracentrifugation and isothermal titration calorimetry. These measurements produce a value of K(d) for the complex of about 0.5 microM.

  11. Crosstalk between complement and Toll-like receptor activation in relation to donor brain death and renal ischemia-reperfusion injury.

    Science.gov (United States)

    Damman, Jeffrey; Daha, Mohamed R; van Son, Willem J; Leuvenink, Henri G; Ploeg, Rutger J; Seelen, Marc A

    2011-04-01

    Two central pathways of innate immunity, complement and Toll-like receptors (TLRs), play an important role in the pathogenesis of renal injury inherent to kidney transplantation. Recent findings indicate close crosstalk between complement and TLR signaling pathways. It is suggested that mitogen activated protein kinases (MAPKs) might be the key molecules linking both the complement and TLR pathways together. Complement and TLRs are important mediators of renal ischemia-reperfusion injury (IRI). Besides IRI, complement C3 can also be upregulated and activated in the kidney before transplantation as a direct result of brain death (BD) in the donor. This local upregulation and activation of complement in the donor kidney has been proven to be detrimental for renal allograft outcome. Also TLR4 and several of its major ligands are upregulated by donor BD compared to living donors. Important and in line with the observations above, kidney transplant recipients have a benefit when receiving a kidney from a TLR4 Asp299Gly/Thr399Ile genotypic donor. The role of complement and TLRs and crosstalk between these two innate immune systems in relation to renal injury during donor BD and ischemia-reperfusion are focus of this review. Future strategies to target complement and TLR activation in kidney transplantation are considered. ©2011 The Authors Journal compilation©2011 The American Society of Transplantation and the American Society of Transplant Surgeons.

  12. Fibrinogen cleavage products and Toll-like receptor 4 promote the generation of programmed cell death 1 ligand 2-positive dendritic cells in allergic asthma.

    Science.gov (United States)

    Cho, Minkyoung; Lee, Jeong-Eun; Lim, Hoyong; Shin, Hyun-Woo; Khalmuratova, Roza; Choi, Garam; Kim, Hyuk Soon; Choi, Wahn Soo; Park, Young-Jun; Shim, Inbo; Kim, Byung-Seok; Kang, Chang-Yuil; Kim, Jae-Ouk; Tanaka, Shinya; Kubo, Masato; Chung, Yeonseok

    2017-10-14

    Inhaled protease allergens preferentially trigger T H 2-mediated inflammation in allergic asthma. The role of dendritic cells (DCs) on induction of T H 2 cell responses in allergic asthma has been well documented; however, the mechanism by which protease allergens induce T H 2-favorable DCs in the airway remains unclear. We sought to determine a subset of DCs responsible for T H 2 cell responses in allergic asthma and the mechanism by which protease allergens induce the DC subset in the airway. Mice were challenged intranasally with protease allergens or fibrinogen cleavage products (FCPs) to induce allergic airway inflammation. DCs isolated from mediastinal lymph nodes were analyzed for surface phenotype and T-cell stimulatory function. Anti-Thy1.2 and Mas-TRECK mice were used to deplete innate lymphoid cells and mast cells, respectively. Adoptive cell transfer, bone marrow DC culture, anti-IL-13, and Toll-like receptor (TLR) 4-deficient mice were used for further mechanistic studies. Protease allergens induced a remarkable accumulation of T H 2-favorable programmed cell death 1 ligand 2 (PD-L2) + DCs in mediastinal lymph nodes, which was significantly abolished in mice depleted of mast cells and, to a lesser extent, innate lymphoid cells. Mechanistically, FCPs generated by protease allergens triggered IL-13 production from wild-type mast cells but not from TLR4-deficient mast cells, which resulted in an increase in the number of PD-L2 + DCs. Intranasal administration of FCPs induced an increase in numbers of PD-L2 + DCs in the airway, which was significantly abolished in TLR4- and mast cell-deficient mice. Injection of IL-13 restored the PD-L2 + DC population in mice lacking mast cells. Our findings unveil the "protease-FCP-TLR4-mast cell-IL-13" axis as a molecular mechanism for generation of T H 2-favorable PD-L2 + DCs in allergic asthma and suggest that targeting the PD-L2 + DC pathway might be effective in suppressing allergic T-cell responses in the airway

  13. Absence of Toll-Like Receptor 4 Signaling Results in Delayed Yersinia enterocolitica YopP-Induced Cell Death of Dendritic Cells

    Czech Academy of Sciences Publication Activity Database

    Gröbner, S.; Schulz, S.; Adkins, Irena; Gunst, D. S. J.; Waibel, M.; Wesselborg, S.; Borgmann, S.; Autenrieth, I. B.

    2007-01-01

    Roč. 75, č. 1 (2007), s. 512-517 ISSN 0019-9567 Institutional research plan: CEZ:AV0Z50200510 Keywords : yersinia enterocolitica * toll-like receptor 4 * dendritic cell s Subject RIV: EC - Immunology Impact factor: 3.996, year: 2007

  14. Crosstalk between Complement and Toll-like Receptor Activation in Relation to Donor Brain Death and Renal Ischemia-Reperfusion Injury

    NARCIS (Netherlands)

    Damman, Jeffrey; Daha, Mohamed R.; van Son, Willem J.; Leuvenink, Henri G.; Ploeg, Rutger J.; Seelen, Marc A.

    Two central pathways of innate immunity, complement and Toll-like receptors (TLRs), play an important role in the pathogenesis of renal injury inherent to kidney transplantation. Recent findings indicate close crosstalk between complement and TLR signaling pathways. It is suggested that mitogen

  15. Evaluating the extent of cell death in 3D high frequency ultrasound by registration with whole-mount tumor histopathology

    International Nuclear Information System (INIS)

    Vlad, Roxana M.; Kolios, Michael C.; Moseley, Joanne L.; Czarnota, Gregory J.; Brock, Kristy K.

    2010-01-01

    Purpose: High frequency ultrasound imaging, 10-30 MHz, has the capability to assess tumor response to radiotherapy in mouse tumors as early as 24 h after treatment administration. The advantage of this technique is that the image contrast is generated by changes in the physical properties of dying cells. Therefore, a subject can be imaged before and multiple times during the treatment without the requirement of injecting specialized contrast agents. This study is motivated by a need to provide metrics of comparison between the volume and localization of cell death, assessed from histology, with the volume and localization of cell death surrogate, assessed as regions with increased echogeneity from ultrasound images. Methods: The mice were exposed to radiation doses of 2, 4, and 8 Gy. Ultrasound images were collected from each tumor before and 24 h after exposure to radiation using a broadband 25 MHz center frequency transducer. After radiotherapy, tumors exhibited hyperechoic regions in ultrasound images that corresponded to areas of cell death in histology. The ultrasound and histological images were rigidly registered. The tumors and regions of cell death were manually outlined on histological images. Similarly, the tumors and hyperechoic regions were outlined on the ultrasound images. Each set of contours was converted to a volumetric mesh in order to compare the volumes and the localization of cell death in histological and ultrasound images. Results: A shrinkage factor of 17±2% was calculated from the difference in the tumor volumes evaluated from histological and ultrasound images. This was used to correct the tumor and cell death volumes assessed from histology. After this correction, the average absolute difference between the volume of cell death assessed from ultrasound and histological images was 11±14% and the volume overlap was 70±12%. Conclusions: The method provided metrics of comparison between the volume of cell death assessed from histology and

  16. Mystika Eckharta Tolle

    OpenAIRE

    Všetečka, Jan

    2014-01-01

    This work brings the mysticism of Eckhart Tolle, spiritual teacher who combines his teaching various spiritual movements and religions. Tolle 's non-denominational teachings addressed to anyone looking for a way to break free from the drawbacks that entails today's way of life . Includes biography Eckhart Tolle . There are Tolle explains the main concepts of mind as mind , consciousness , being, ego , emotional body ( pain ), presence , silence, space , acceptance , surrender, awakening and l...

  17. Executive report : toll roads, toll rates, and driver behavior.

    Science.gov (United States)

    2012-12-01

    State and federal research has examined toll roads and attempted to identify methods to make toll roads a more attractive option for drivers. Researchers examined various views of toll road transactions and concluded: : Truckers and trucking comp...

  18. Shadow Toll in Colombia

    OpenAIRE

    González Ruiz, Juan David; Botero Botero, Sergio; Arboleda, Carlos Alejandro; Duque Grisales, Eduardo Alexander

    2015-01-01

    The growing development in infrastructure projects in Colombia has been linked to legal adjustments and capital markets. These two last factors have provided important elements for project developers to design funding strategies. Based on the shadow toll scheme, this paper proposes a new financing strategy for funding highway projects. This strategy may be implemented in Colombia. Finally, the paper proposes future research on shadow toll schemes as a financial mechanism.

  19. Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia

    NARCIS (Netherlands)

    Scheffel, Joerg; Regen, Tommy; Van Rossum, Denise; Seifert, Stefanie; Ribes, Sandra; Nau, Roland; Parsa, Roham; Harris, Robert A.; Boddeke, Hendrikus W. G. M.; Chuang, Han-Ning; Pukrop, Tobias; Wessels, Johannes T.; Juergens, Tanja; Merkler, Doron; Brueck, Wolfgang; Schnaars, Mareike; Simons, Mikael; Kettenmann, Helmut; Hanisch, Uwe-Karsten

    2012-01-01

    The sentinel and immune functions of microglia require rapid and appropriate reactions to infection and damage. Their Toll-like receptors (TLRs) sense both as threats. However, whether activated microglia mount uniform responses or whether subsets conduct selective tasks is unknown. We demonstrate

  20. Toll Facilities in the United States

    Data.gov (United States)

    Department of Transportation — Biennial report containing selected information on toll facilities in the United States that has been provided to FHWA by the States and/or various toll authorities...

  1. Technology scan for electronic toll collection.

    Science.gov (United States)

    2008-06-01

    The purpose of this project was to identify and assess available technologies and methodologies for electronic toll collection (ETC) and to develop recommendations for the best way(s) to implement toll collection in the Louisville metropolitan area. ...

  2. PV module mounting method and mounting assembly

    Science.gov (United States)

    Lenox, Carl J.S.; Johnson, Kurt M.

    2013-04-23

    A method for mounting PV modules to a deck includes selecting PV module layout pattern so that adjacent PV module edges are spaced apart. PV mounting and support assemblies are secured to the deck according to the layout pattern using fasteners extending into the deck. The PV modules are placed on the PV mounting and support assemblies. Retaining elements are located over and secured against the upper peripheral edge surfaces of the PV modules so to secure them to the deck with the peripheral edges of the PV modules spaced apart from the deck. In some examples a PV module mounting assembly, for use on a shingled deck, comprises flashing, a base mountable on the flashing, a deck-penetrating fastener engageable with the base and securable to the deck so to secure the flashing and the base to the shingled deck, and PV module mounting hardware securable to the base.

  3. Magnetic core mounting system

    Science.gov (United States)

    Ronning, Jeffrey J.

    2002-01-01

    A mounting apparatus for an electromagnetic device such as a transformer of inductor includes a generally planar metallic plate as a first heat sink, and a metallic mounting cup as a second heat sink. The mounting cup includes a cavity configured to receive the electromagnetic device, the cavity being defined by a base, and an axially-extending annular sidewall extending from the base to a flange portion of the mounting cup. The mounting cup includes first and second passages for allowing the leads of first and second windings of the electromagnetic device to be routed out of the cavity. The cavity is filled with a polyurethane potting resin, and the mounting cup, including the potted electromagnetic device, is mounted to the plate heat sink using fasteners. The mounting cup, which surrounds the electromagnetic device, in combination with the potting resin provides improved thermal transfer to the plate heat sink, as well as providing resistance to vibration and shocks.

  4. Photovoltaic module mounting system

    Science.gov (United States)

    Miros, Robert H. J. [Fairfax, CA; Mittan, Margaret Birmingham [Oakland, CA; Seery, Martin N [San Rafael, CA; Holland, Rodney H [Novato, CA

    2012-04-17

    A solar array mounting system having unique installation, load distribution, and grounding features, and which is adaptable for mounting solar panels having no external frame. The solar array mounting system includes flexible, pedestal-style feet and structural links connected in a grid formation on the mounting surface. The photovoltaic modules are secured in place via the use of attachment clamps that grip the edge of the typically glass substrate. The panel mounting clamps are then held in place by tilt brackets and/or mid-link brackets that provide fixation for the clamps and align the solar panels at a tilt to the horizontal mounting surface. The tilt brackets are held in place atop the flexible feet and connected link members thus creating a complete mounting structure.

  5. Toll Facilities in the United States - Toll Facilities in the United States

    Data.gov (United States)

    Department of Transportation — Biennial report containing selected information on toll facilities in the United States that has been provided to FHWA by the States and/or various toll authorities...

  6. Liner mounting assembly

    Science.gov (United States)

    Halila, Ely E. (Inventor)

    1994-01-01

    A mounting assembly includes an annular supporting flange disposed coaxially about a centerline axis which has a plurality of circumferentially spaced apart supporting holes therethrough. An annular liner is disposed coaxially with the supporting flange and includes a plurality of circumferentially spaced apart mounting holes aligned with respective ones of the supporting holes. Each of a plurality of mounting pins includes a proximal end fixedly joined to the supporting flange through a respective one of the supporting holes, and a distal end disposed through a respective one of the liner mounting holes for supporting the liner to the supporting flange while unrestrained differential thermal movement of the liner relative to the supporting flange.

  7. Toll mediated infection response is altered by gravity and spaceflight in Drosophila.

    Directory of Open Access Journals (Sweden)

    Katherine Taylor

    Full Text Available Space travel presents unlimited opportunities for exploration and discovery, but requires better understanding of the biological consequences of long-term exposure to spaceflight. Immune function in particular is relevant for space travel. Human immune responses are weakened in space, with increased vulnerability to opportunistic infections and immune-related conditions. In addition, microorganisms can become more virulent in space, causing further challenges to health. To understand these issues better and to contribute to design of effective countermeasures, we used the Drosophila model of innate immunity to study immune responses in both hypergravity and spaceflight. Focusing on infections mediated through the conserved Toll and Imd signaling pathways, we found that hypergravity improves resistance to Toll-mediated fungal infections except in a known gravitaxis mutant of the yuri gagarin gene. These results led to the first spaceflight project on Drosophila immunity, in which flies that developed to adulthood in microgravity were assessed for immune responses by transcription profiling on return to Earth. Spaceflight alone altered transcription, producing activation of the heat shock stress system. Space flies subsequently infected by fungus failed to activate the Toll pathway. In contrast, bacterial infection produced normal activation of the Imd pathway. We speculate on possible linkage between functional Toll signaling and the heat shock chaperone system. Our major findings are that hypergravity and spaceflight have opposing effects, and that spaceflight produces stress-related transcriptional responses and results in a specific inability to mount a Toll-mediated infection response.

  8. Optoelectronic Mounting Structure

    Science.gov (United States)

    Anderson, Gene R.; Armendariz, Marcelino G.; Baca, Johnny R. F.; Bryan, Robert P.; Carson, Richard F.; Chu, Dahwey; Duckett, III, Edwin B.; McCormick, Frederick B.; Peterson, David W.; Peterson, Gary D.; Reber, Cathleen A.; Reysen, Bill H.

    2004-10-05

    An optoelectronic mounting structure is provided that may be used in conjunction with an optical transmitter, receiver or transceiver module. The mounting structure may be a flexible printed circuit board. Thermal vias or heat pipes in the head region may transmit heat from the mounting structure to the heat spreader. The heat spreader may provide mechanical rigidity or stiffness to the heat region. In another embodiment, an electrical contact and ground plane may pass along a surface of the head region so as to provide an electrical contact path to the optoelectronic devices and limit electromagnetic interference. In yet another embodiment, a window may be formed in the head region of the mounting structure so as to provide access to the heat spreader. Optoelectronic devices may be adapted to the heat spreader in such a manner that the devices are accessible through the window in the mounting structure.

  9. Death and Death Anxiety

    OpenAIRE

    Gonca Karakus; Zehra Ozturk; Lut Tamam

    2012-01-01

    Although death and life concepts seem so different from each other, some believe that death and life as a whole that death is accepted as the goal of life and death completes life. In different cultures, societies and disciplines, there have been very different definitions of death which changes according to personality, age, religion and cultural status of the individual. Attitudes towards death vary dramatically according to individuals. As for the death anxiety, it is a feeling which start...

  10. Internally Mounting Strain Gages

    Science.gov (United States)

    Jett, J. R., Jr.

    1984-01-01

    Technique for mounting strain gages inside bolt or cylinder simultaneously inserts gage, attached dowel segment, and length of expandable tubing. Expandable tubing holds gage in place while adhesive cures, assuring even distribution of pressure on gage and area gaged.

  11. Mounting for ceramic scroll

    Science.gov (United States)

    Petty, Jack D.

    1993-01-01

    A mounting for a ceramic scroll on a metal engine block of a gas turbine engine includes a first ceramic ring and a pair of cross key connections between the first ceramic ring, the ceramic scroll, and the engine block. The cross key connections support the scroll on the engine block independent of relative radial thermal growth and for bodily movement toward an annular mounting shoulder on the engine. The scroll has an uninterrupted annular shoulder facing the mounting shoulder on the engine block. A second ceramic ring is captured between mounting shoulder and the uninterrupted shoulder on the scroll when the latter is bodily shifted toward the mouting shoulder to define a gas seal between the scroll and the engine block.

  12. Occupational Noise Exposure among Toll Tellers at Toll Plaza in Malaysia

    Science.gov (United States)

    Azmi, Sharifah Nadya Syed; Dawal, Siti Zawiah Md; Ya, Tuan Mohammad Yusoff Shah Tuan; Saidin, Hamidi

    2010-10-01

    Toll tellers working at toll plaza have potential of exposure to high noise from the vehicles especially for the peak level of sound emitted by the heavy vehicles. However, occupational exposures in this workplace have not been adequately characterized and identified. Occupational noise exposure among toll tellers at toll plaza was assessed using Sound Level Meter, Noise Dosimeter and through questionnaire survey. These data were combined to estimate the work shift exposure level and health impacts to the toll tellers by using statistical analysis. Noise Dosimeter microphone was located at the hearing zone of the toll teller which working inside the toll booth and full-period measurements were collected for each work shift. The measurements were taken at 20 toll booths from 6.00 am to 2.00 pm for 5 days. 71 respondents participated in the survey to identify the symptoms of noise induced hearing loss and other health related problems among toll tellers. Results of this study indicated that occupational noise exposure among toll tellers for Mean Continuous Equivalent Level, Leq was 79.2±1.4 dB(A), Mean Maximum Level, Lmax was 107.8±3.6 dB(A) and Mean Peak Level, Lpeak was 136.6±9.9 dB. The Peak Level reported statistically significantly at 140 dB, the level of TLV recommended by ACGIH. The research findings indicated that the primary risk exposure to toll tellers comes from noise that emitted from heavy vehicles. Most of the toll tellers show symptoms of noise induced hearing loss and annoyed by the sources of noise at the toll plaza.

  13. Photovoltaic mounting/demounting unit

    DEFF Research Database (Denmark)

    2014-01-01

    The present invention relates to a photovoltaic arrangement comprising a photovoltaic assembly comprising a support structure defining a mounting surface onto which a photovoltaic module is detachably mounted; and a mounting/demounting unit comprising at least one mounting/demounting apparatus...... which when the mounting/demounting unit is moved along the mounting surface, causes the photovoltaic module to be mounted or demounted to the support structure; wherein the photovoltaic module comprises a carrier foil and wherein a total thickness of the photo voltaic module is below 500 muiotaeta....... The present invention further relates to an associated method for mounting/demounting photovoltaic modules....

  14. 47 CFR 42.6 - Retention of telephone toll records.

    Science.gov (United States)

    2010-10-01

    ... whether it is billing its own toll service customers for toll calls or billing customers for another... Section 42.6 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES... telephone toll records. Each carrier that offers or bills toll telephone service shall retain for a period...

  15. Simulation of investment returns of toll projects.

    Science.gov (United States)

    2013-08-01

    This research develops a methodological framework to illustrate key stages in applying the simulation of investment returns of toll projects, acting as an example process of helping agencies conduct numerical risk analysis by taking certain uncertain...

  16. Toll-like receptors in neonatal sepsis.

    LENUS (Irish Health Repository)

    O'Hare, Fiona M

    2013-06-01

    Toll-like receptors are vital transmembrane receptors that initiate the innate immune response to many micro-organisms. The discovery of these receptors has improved our understanding of host-pathogen interactions, and these receptors play an important role in the pathogenesis of multiple neonatal conditions such as sepsis and brain injury. Toll-like receptors, especially TLRs 2 and 4, are associated with necrotizing enterocolitis, periventricular leukomalacia and sepsis.

  17. DMPD: Toll-like receptor 3: a link between toll-like receptor, interferon and viruses. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15031527 Toll-like receptor 3: a link between toll-like receptor, interferon and virus... (.csml) Show Toll-like receptor 3: a link between toll-like receptor, interferon and viruses. PubmedID 1503...1527 Title Toll-like receptor 3: a link between toll-like receptor, interferon and virus

  18. Housing And Mounting Structure

    Science.gov (United States)

    Anderson, Gene R.; Armendariz, Marcelino G.; Baca, Johnny R.F.; Bryan, Robert P.; Carson, Richard F.; Duckett, III, Edwin B.; McCormick, Frederick B.; Miller, Gregory V.; Peterson, David W.; Smith, Terrance T.

    2005-03-08

    This invention relates to an optical transmitter, receiver or transceiver module, and more particularly, to an apparatus for connecting a first optical connector to a second optical connector. The apparatus comprises: (1) a housing having at least a first end and at least a second end, the first end of the housing capable of receiving the first optical connector, and the second end of the housing capable of receiving the second optical connector; (2) a longitudinal cavity extending from the first end of the housing to the second end of the housing; and (3) an electromagnetic shield comprising at least a portion of the housing. This invention also relates to an apparatus for housing a flexible printed circuit board, and this apparatus comprises: (1) a mounting structure having at least a first surface and a second surface; (2) alignment ridges along the first and second surfaces of the mounting structure, the alignment ridges functioning to align and secure a flexible printed circuit board that is wrapped around and attached to the first and second surfaces of the mounting structure; and (3) a series of heat sink ridges adapted to the mounting structure, the heat sink ridges functioning to dissipate heat that is generated from the flexible printed circuit board.

  19. Transducer-Mounting Fixture

    Science.gov (United States)

    Spiegel, Kirk W.

    1990-01-01

    Transducer-mounting fixture holds transducer securely against stud. Projects only slightly beyond stud after installation. Flanged transducer fits into fixture when hinged halves open. When halves reclosed, fixture tightened onto threaded stud until stud makes contact with transducer. Knurled area on fixture aids in tightening fixture on stud.

  20. Scintillation crystal mounting apparatus

    International Nuclear Information System (INIS)

    Engdahl, L.W.; Deans, A.J.

    1982-01-01

    An improved detector head for a gamma camera is disclosed. The detector head includes a housing and a detector assembly mounted within the housing. Components of the detector assembly include a crystal sub-assembly, a phototube array, and a light pipe between the phototube array and crystal sub-assembly. The invention provides a unique structure for maintaining the phototubes in optical relationship with the light pipe and preventing the application of forces that would cause the camera's crystal to crack

  1. Role of climate variability in the heatstroke death rates of Kanto region in Japan

    Science.gov (United States)

    Akihiko, Takaya; Morioka, Yushi; Behera, Swadhin K.

    2014-07-01

    The death toll by heatstroke in Japan, especially in Kanto region, has sharply increased since 1994 together with large interannual variability. The surface air temperature and humidity observed during boreal summers of 1980-2010 were examined to understand the role of climate in the death toll. The extremely hot days, when the daily maximum temperature exceeds 35°C, are more strongly associated with the death toll than the conventional Wet Bulb Globe Temperature index. The extremely hot days tend to be associated with El Niño/Southern Oscillation or the Indian Ocean Dipole, suggesting a potential link with tropical climate variability to the heatstroke related deaths. Also, the influence of these climate modes on the death toll has strengthened since 1994 probably related to global warming. It is possible to develop early warning systems based on seasonal climate predictions since recent climate models show excellent predictability skills for those climate modes.

  2. Characterization of Engine Mount Elastomers

    National Research Council Canada - National Science Library

    Szabo, Jeffrey P

    2005-01-01

    As part of a project to develop methods for modelling the performance of engine mounts, several oil resistant alternative materials were prepared, and compared to conventional materials from mounts...

  3. Neonatal Death

    Science.gov (United States)

    ... Home > Complications & Loss > Loss & grief > Neonatal death Neonatal death E-mail to a friend Please fill in ... cope with your baby’s death. What is neonatal death? Neonatal death is when a baby dies in ...

  4. Congestion Tolling for Mixed Urban Freight and Passenger Traffic

    Directory of Open Access Journals (Sweden)

    Xie Chaoda

    2017-01-01

    Full Text Available This paper investigates the welfare effects of optimal tolling on urban traffic congestion, in a bottleneck model, with mixed freight and passenger users. The users’ marginal utility of time is considered to be varying with time. Under both no-toll equilibrium and socially optimal tolling, the users are found to sort their arrival time according to the increasing rates of marginal utility at the destination. The optimal toll that maximizes social welfare does not change each user's indirect utilit y relative to the no-toll equilibrium, but completely removes the queue, which also removes the barrier of freight carriers to accept congestion pricing by relating their marginal utilities directly to the toll. When the toll is equally rebated, the proposed social optimal tolling is a Pareto improvement relative to the no-toll equilibrium. Those more productive users also suffer more in both no-toll equilibrium and optimal tolling, which indicates that a differentiated redistribution of toll revenues could be an incentive to improve productivity.

  5. A self-adaptive toll rate algorithm for high occupancy toll (HOT) lane operations.

    Science.gov (United States)

    2009-12-01

    Dramatically increasing travel demands and insufficient traffic facility supplies have resulted in severe : traffic congestion. High Occupancy Toll (HOT) lane operations have been proposed as one of the most : applicable and cost-effective countermea...

  6. Risk neutral second best toll pricing.

    Science.gov (United States)

    2011-08-01

    We propose a risk-neutral second best toll pricing scheme to account for the possible no uniqueness : of user equilibrium solutions. The scheme is designed to optimize for the expected objective value : as the UE solution varies within the solution s...

  7. Resilient mounting systems in buildings

    NARCIS (Netherlands)

    Breeuwer, R.; Tukker, J.C.

    1976-01-01

    The basic elements of resilient mounting systems are described and various measures for quantifying the effect of such systems defined. Using electrical analogue circuits, the calculation of these measures is illustrated. With special reference to resilient mounting systems in buildings, under

  8. Mount Rainier National Park

    Science.gov (United States)

    Hoffman, Robert; Woodward, Andrea; Haggerty, Patricia K.; Jenkins, Kurt J.; Griffin, Paul C.; Adams, Michael J.; Hagar, Joan; Cummings, Tonnie; Duriscoe, Dan; Kopper, Karen; Riedel, Jon; Samora, Barbara; Marin, Lelaina; Mauger, Guillaume S.; Bumbaco, Karen; Littell, Jeremy S.

    2014-01-01

    Natural Resource Condition Assessments (NRCAs) evaluate current conditions for a subset of natural resources and resource indicators in national parks. NRCAs also report on trends in resource condition (when possible), identify critical data gaps, and characterize a general level of confidence for study findings. The resources and indicators emphasized in a given project depend on the park’s resource setting, status of resource stewardship planning and science in identifying high-priority indicators, and availability of data and expertise to assess current conditions for a variety of potential study resources and indicators. Although the primary objective of NRCAs is to report on current conditions relative to logical forms of reference conditions and values, NRCAs also report on trends, when appropriate (i.e., when the underlying data and methods support such reporting), as well as influences on resource conditions. These influences may include past activities or conditions that provide a helpful context for understanding current conditions and present-day threats and stressors that are best interpreted at park, watershed, or landscape scales (though NRCAs do not report on condition status for land areas and natural resources beyond park boundaries). Intensive cause-andeffect analyses of threats and stressors, and development of detailed treatment options, are outside the scope of NRCAs. It is also important to note that NRCAs do not address resources that lack sufficient data for assessment. For Mount Rainier National Park, this includes most invertebrate species and many other animal species that are subject to significant stressors from climate change and other anthropogenic sources such as air pollutants and recreational use. In addition, we did not include an analysis of the physical hydrology associated with streams (such as riverine landforms, erosion and aggradation which is significant in MORA streams), due to a loss of staff expertise from the USGS

  9. 23 CFR 950.5 - Requirement to use electronic toll collection technology.

    Science.gov (United States)

    2010-04-01

    ... shall use an electronic toll collection system as the method for collecting tolls from vehicle operators... 23 Highways 1 2010-04-01 2010-04-01 false Requirement to use electronic toll collection technology... TRANSPORTATION SYSTEMS ELECTRONIC TOLL COLLECTION § 950.5 Requirement to use electronic toll collection...

  10. Carbon Monoxide Poisoning: Death on Mount McKinley,

    Science.gov (United States)

    1987-05-08

    Additionally, studies by Astrup(5) and Thomas(6) have reported decreased erythrocytic 2, 3- diphosphoglycerate (2, 3-DPG) concentrations with acute...Halebian, et al found no significant difference in measured 02 consumption or extraction between dogs subjected to CO poisoning vs nitrogen anoxia .(9...Astrup P: Intraerythrocytic 2,3- diphosphoglycerate and carbon monoxide exposure. Ann NY Acad Sci 1970;174:252-254. 6. Thomas MF, Penny DG: Hematologic

  11. Detector Mount Design for IGRINS

    Directory of Open Access Journals (Sweden)

    Jae Sok Oh

    2014-06-01

    Full Text Available The Immersion Grating Infrared Spectrometer (IGRINS is a near-infrared wide-band high-resolution spectrograph jointly developed by the Korea Astronomy and Space Science Institute and the University of Texas at Austin. IGRINS employs three HAWAII-2RG Focal Plane Array (H2RG FPA detectors. We present the design and fabrication of the detector mount for the H2RG detector. The detector mount consists of a detector housing, an ASIC housing, a Field Flattener Lens (FFL mount, and a support base frame. The detector and the ASIC housing should be kept at 65 K and the support base frame at 130 K. Therefore they are thermally isolated by the support made of GFRP material. The detector mount is designed so that it has features of fine adjusting the position of the detector surface in the optical axis and of fine adjusting yaw and pitch angles in order to utilize as an optical system alignment compensator. We optimized the structural stability and thermal characteristics of the mount design using computer-aided 3D modeling and finite element analysis. Based on the structural and thermal analysis, the designed detector mount meets an optical stability tolerance and system thermal requirements. Actual detector mount fabricated based on the design has been installed into the IGRINS cryostat and successfully passed a vacuum test and a cold test.

  12. The Theoretical and Applied Fundamentals of Management of Tolling Operations

    Directory of Open Access Journals (Sweden)

    Melnyk Olha H.

    2018-01-01

    Full Text Available The article is concerned with identification of the unified essence of tolling operations in the scientific terminological apparatus; substantiation of conceptual bases of balanced management of tolling operations; characterization of the current status and tendencies of development of tolling operations at domestic enterprises; allocation and analyzing of factors of influence on tolling operations, and also economic assessment of tolling operations of the processing enterprise. The concept of balanced management of tolling operations has been substantiated, on parity basis considering interests of the customer and executor of processing works. The most essential internal and external factors of influence on tolling operations have been identified and their influence has been interpreted by means of the developed correlation-regression dependencies. The complex model of economic diagnostics of tolling operations of processing enterprise has been improved, allowing to assess efficiency of their implementation both operatively and fundamentally. Prospect for further research is development of an instrumentarium of motivation of participants of tolling operations in order to increase motivation of employees to the efficient implementation of these operations.

  13. Death Cafe.

    Science.gov (United States)

    Miles, Lizzy; Corr, Charles A

    2017-06-01

    This article explains the meaning of the phrase Death Cafe and describes what typically occurs at a Death Cafe gathering. The article traces the history of the Death Cafe movement, explores some reasons why people take part in a Death Cafe gathering, and gives examples of what individuals think they might derive from their participation. In addition, this article notes similarities between the Death Cafe movement and three other developments in the field of death, dying, and bereavement. Finally, this article identifies two provisional lessons that can be drawn from Death Cafe gatherings and the Death Cafe movement itself.

  14. Characteristics of the auto users and non-users of central Texas toll roads.

    Science.gov (United States)

    2009-08-01

    As toll road usage increases to finance new road infrastructure or add capacity to existing road infrastructure, the : question of who does and does not use toll roads becomes increasingly important to toll road developers, financiers, : Traffic and ...

  15. DMPD: Toll like receptors and autoimmunity: a critical appraisal. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17959357 Toll like receptors and autoimmunity: a critical appraisal. Papadimitraki ...ml) Show Toll like receptors and autoimmunity: a critical appraisal. PubmedID 17959357 Title Toll like receptors and auto

  16. Mount Oku, Cameroon Volcanic Line

    African Journals Online (AJOL)

    and continental sectors especially for trace elements in basalts. ... continental sector of the trend is a complex .... values higher than those of HIMU but is within ...... (Mount Cameroon, Central Africa): petrogenetic implications. Miner. Petrol.,.

  17. Solar panel parallel mounting configuration

    Science.gov (United States)

    Mutschler, Jr., Edward Charles (Inventor)

    1998-01-01

    A spacecraft includes a plurality of solar panels interconnected with a power coupler and an electrically operated device to provide power to the device when the solar cells are insolated. The solar panels are subject to bending distortion when entering or leaving eclipse. Spacecraft attitude disturbances are reduced by mounting each of the solar panels to an elongated boom made from a material with a low coefficient of thermal expansion, so that the bending of one panel is not communicated to the next. The boom may be insulated to reduce its bending during changes in insolation. A particularly advantageous embodiment mounts each panel to the boom with a single mounting, which may be a hinge. The single mounting prevents transfer of bending moments from the panel to the boom.

  18. Toll-like receptorer, nye behandlingsstrategier?

    DEFF Research Database (Denmark)

    Pedersen, Claus Vinter Bødker; Østergaard, Lars; Mogensen, Trine

    2007-01-01

    Toll-like receptors (TLRs) comprise a group of recently discovered receptors which are essential molecular structures in the activation of immunity. The discovery of TLRs has provided a substantial increase in the knowledge of immunologic aspects of disease pathology and is presently giving rise...... to new treatment strategies. This review summarizes the current knowledge on TLRs functioning in infections, their possible roles in inflammatory bowl disease and the pivotal role for TLRs in endotoxic shock, an area which is currently subject to development of a new farmakon. Udgivelsesdato: 2007-Jun-4...

  19. Mounting clips for panel installation

    Science.gov (United States)

    Cavieres, Andres; Al-Haddad, Tristan; Goodman, Joseph

    2017-07-11

    A photovoltaic panel mounting clip comprising a base, central indexing tabs, flanges, lateral indexing tabs, and vertical indexing tabs. The mounting clip removably attaches one or more panels to a beam or the like structure, both mechanically and electrically. It provides secure locking of the panels in all directions, while providing guidance in all directions for accurate installation of the panels to the beam or the like structure.

  20. The head-mounted microscope.

    Science.gov (United States)

    Chen, Ting; Dailey, Seth H; Naze, Sawyer A; Jiang, Jack J

    2012-04-01

    Microsurgical equipment has greatly advanced since the inception of the microscope into the operating room. These advancements have allowed for superior surgical precision and better post-operative results. This study focuses on the use of the Leica HM500 head-mounted microscope for the operating phonosurgeon. The head-mounted microscope has an optical zoom from 2× to 9× and provides a working distance from 300 mm to 700 mm. The headpiece, with its articulated eyepieces, adjusts easily to head shape and circumference, and offers a focus function, which is either automatic or manually controlled. We performed five microlaryngoscopic operations utilizing the head-mounted microscope with successful results. By creating a more ergonomically favorable operating posture, a surgeon may be able to obtain greater precision and success in phonomicrosurgery. Phonomicrosurgery requires the precise manipulation of long-handled cantilevered instruments through the narrow bore of a laryngoscope. The head-mounted microscope shortens the working distance compared with a stand microscope, thereby increasing arm stability, which may improve surgical precision. Also, the head-mounted design permits flexibility in head position, enabling operator comfort, and delaying musculoskeletal fatigue. A head-mounted microscope decreases the working distance and provides better ergonomics in laryngoscopic microsurgery. These advances provide the potential to promote precision in phonomicrosurgery. Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.

  1. Mincle suppresses Toll-like receptor 4 activation.

    Science.gov (United States)

    Greco, Stephanie H; Mahmood, Syed Kashif; Vahle, Anne-Kristin; Ochi, Atsuo; Batel, Jennifer; Deutsch, Michael; Barilla, Rocky; Seifert, Lena; Pachter, H Leon; Daley, Donnele; Torres-Hernandez, Alejandro; Hundeyin, Mautin; Mani, Vishnu R; Miller, George

    2016-07-01

    Regulation of Toll-like receptor responses is critical for limiting tissue injury and autoimmunity in both sepsis and sterile inflammation. We found that Mincle, a C-type lectin receptor, regulates proinflammatory Toll-like receptor 4 signaling. Specifically, Mincle ligation diminishes Toll-like receptor 4-mediated inflammation, whereas Mincle deletion or knockdown results in marked hyperresponsiveness to lipopolysaccharide in vitro, as well as overwhelming lipopolysaccharide-mediated inflammation in vivo. Mechanistically, Mincle deletion does not up-regulate Toll-like receptor 4 expression or reduce interleukin 10 production after Toll-like receptor 4 ligation; however, Mincle deletion decreases production of the p38 mitogen-activated protein kinase-dependent inhibitory intermediate suppressor of cytokine signaling 1, A20, and ABIN3 and increases expression of the Toll-like receptor 4 coreceptor CD14. Blockade of CD14 mitigates the increased sensitivity of Mincle(-/-) leukocytes to Toll-like receptor 4 ligation. Collectively, we describe a major role for Mincle in suppressing Toll-like receptor 4 responses and implicate its importance in nonmycobacterial models of inflammation. © Society for Leukocyte Biology.

  2. Toll-like receptors in brain development and homeostasis

    DEFF Research Database (Denmark)

    Larsen, Peter H; Holm, Thomas Hellesøe; Owens, Trevor

    2007-01-01

    Toll-like receptors (TLRs) are best known as initiators of the innate immune response to pathogens. Recent reports now reveal intriguing roles for TLRs in the central nervous system (CNS). These include the regulation of neuroinflammation and of neurite outgrowth. The archetypal Toll protein in D...

  3. Solar panel truss mounting systems and methods

    Energy Technology Data Exchange (ETDEWEB)

    Al-Haddad, Tristan Farris; Cavieres, Andres; Gentry, Russell; Goodman, Joseph; Nolan, Wade; Pitelka, Taylor; Rahimzadeh, Keyan; Brooks, Bradley; Lohr, Joshua; Crooks, Ryan; Porges, Jamie; Rubin, Daniel

    2016-06-28

    An exemplary embodiment of the present invention provides a solar panel truss mounting system comprising a base and a truss assembly coupled to the base. The truss assembly comprises a first panel rail mount, second panel rail mount parallel to the first panel rail mount, base rail mount parallel to the first and second panel rail mounts, and a plurality of support members. A first portion of the plurality of support members extends between the first and second panel rail mounts. A second portion of the plurality of support members extends between the first panel rail mount and the base rail mount. A third portion of the plurality of support members extends between the second panel rail mount and the base rail mount. The system can further comprise a plurality of connectors for coupling a plurality of photovoltaic solar panels to the truss assembly.

  4. Solar panel truss mounting systems and methods

    Energy Technology Data Exchange (ETDEWEB)

    Al-Haddad, Tristan Farris; Cavieres, Andres; Gentry, Russell; Goodman, Joseph; Nolan, Wade; Pitelka, Taylor; Rahimzadeh, Keyan; Brooks, Bradley; Lohr, Joshua; Crooks, Ryan; Porges, Jamie; Rubin, Daniel

    2018-01-30

    An exemplary embodiment of the present invention provides a solar panel truss mounting system comprising a base and a truss assembly coupled to the base. The truss assembly comprises a first panel rail mount, second panel rail mount parallel to the first panel rail mount, base rail mount parallel to the first and second panel rail mounts, and a plurality of support members. A first portion of the plurality of support members extends between the first and second panel rail mounts. A second portion of the plurality of support members extends between the first panel rail mount and the base rail mount. A third portion of the plurality of support members extends between the second panel rail mount and the base rail mount. The system can further comprise a plurality of connectors for coupling a plurality of photovoltaic solar panels to the truss assembly.

  5. Solar panel truss mounting systems and methods

    Science.gov (United States)

    Al-Haddad, Tristan Farris; Cavieres, Andres; Gentry, Russell; Goodman, Joseph; Nolan, Wade; Pitelka, Taylor; Rahimzadeh, Keyan; Brooks, Bradley; Lohr, Joshua; Crooks, Ryan; Porges, Jamie; Rubin, Daniel

    2015-10-20

    An exemplary embodiment of the present invention provides a solar panel truss mounting system comprising a base and a truss assembly coupled to the base. The truss assembly comprises a first panel rail mount, second panel rail mount parallel to the first panel rail mount, base rail mount parallel to the first and second panel rail mounts, and a plurality of support members. A first portion of the plurality of support members extends between the first and second panel rail mounts. A second portion of the plurality of support members extends between the first panel rail mount and the base rail mount. A third portion of the plurality of support members extends between the second panel rail mount and the base rail mount. The system can further comprise a plurality of connectors for coupling a plurality of photovoltaic solar panels to the truss assembly.

  6. Toll-like receptor 2 or toll-like receptor 4 deficiency does not modify lupus in MRLlpr mice.

    Directory of Open Access Journals (Sweden)

    Simon J Freeley

    Full Text Available Systemic lupus erythematosus is an autoimmune disease with a high morbidity and nephritis is a common manifestation. Previous studies in murine lupus models have suggest a role for Toll-like receptor 2 and 4. We examined the role of these molecules in MRL lpr mice which is one of the most established and robust murine models. We compared disease parameters in Toll-like receptor 2 or Toll-like receptor 4 deficient mice with their littermate controls. We found no difference in the severity of glomerulonephritis as assessed by histology, serum creatinine and albuminuria when Toll-like receptor 2 or Toll-like receptor 4 deficient MRLlpr mice were compared with Toll-like receptor sufficient controls. We also found similar levels of anti-dsDNA and anti-ssDNA antibodies. These results show that Toll-like receptor 2 and Toll-like receptor 4 do not play a significant role in MRLlpr mice, and therefore they may not be important in human lupus.

  7. miR-958 inhibits Toll signaling and Drosomycin expression via direct targeting of Toll and Dif in Drosophila melanogaster.

    Science.gov (United States)

    Li, Shengjie; Li, Yao; Shen, Li; Jin, Ping; Chen, Liming; Ma, Fei

    2017-02-01

    Drosophila melanogaster is widely used as a model system to study innate immunity and signaling pathways related to innate immunity, including the Toll signaling pathway. Although this pathway is well studied, the precise mechanisms of posttranscriptional regulation of key components of the Toll signaling pathway by microRNAs (miRNAs) remain obscure. In this study, we used an in silico strategy in combination with the Gal80 ts -Gal4 driver system to identify microRNA-958 (miR-958) as a candidate Toll pathway regulating miRNA in Drosophila We report that overexpression of miR-958 significantly reduces the expression of Drosomycin, a key antimicrobial peptide involved in Toll signaling and the innate immune response. We further demonstrate in vitro and in vivo that miR-958 targets the Toll and Dif genes, key components of the Toll signaling pathway, to negatively regulate Drosomycin expression. In addition, a miR-958 sponge rescued the expression of Toll and Dif, resulting in increased expression of Drosomycin. These results, not only revealed a novel function and modulation pattern of miR-958, but also provided a new insight into the underlying molecular mechanisms of Toll signaling in regulation of innate immunity. Copyright © 2017 the American Physiological Society.

  8. Deliberating death.

    Science.gov (United States)

    Landes, Scott D

    2010-01-01

    Utilizing a particular case study of a woman attempting to come to terms with her death, this article explores the difficult metaphors of death present within the Christian tradition. Tracing a Christian understanding of death back to the work of Augustine, the case study is utilized to highlight the difficulties presented by past and present theology embracing ideas of punishment within death. Following the trajectory of the case study, alternative understandings of death present in recent Christian theology and within Native American spirituality are presented in an attempt to find room for a fuller meaning of death post-reconciliation, but premortem.

  9. Cloning and Analysis of Gene Expression of Two Toll Receptors in Freshwater Pearl Mussel Hyriopsis cumingii

    Directory of Open Access Journals (Sweden)

    Ying Huang

    2018-03-01

    Full Text Available Toll receptors are involved in innate immunity of invertebrates. In this study, we identify and characterize two Toll genes (named HcToll4 and HcToll5 from triangle sail mussel Hyriopsis cumingii. HcToll4 has complete cDNA sequence of 3,162 bp and encodes a protein of 909 amino acids. HcToll5 cDNA is 4,501 bp in length and encodes a protein of 924 amino acids. Both deduced HcToll4 and HcToll5 protein contain signal peptide, extracellular leucine rich repeats (LRRs, and intracellular Toll/interleukin-1 (IL-1 receptor domains. Quantitative real-time PCR analysis revealed that HcToll4 and HcToll5 were largely distributed in the hepatopancreas and could be detected in the gills and mantle. HcToll4 and HcToll5 expression could respond to Staphylococcus aureus, Vibrio parahaemolyticus, White spot syndrome virus (WSSV or Poly I:C challenge. RNA interference by siRNA results showed that HcToll4 and HcToll5 were involved in the regulation of theromacin (HcThe and whey acidic protein (HcWAP expression. Based on these results, HcToll4 and HcToll5 might play pivotal function in H. cumingii innate immune response.

  10. Mounting clips for panel installation

    Science.gov (United States)

    Cavieres, Andres; Al-Haddad, Tristan; Goodman, Joseph; Valdes, Francisco

    2017-02-14

    An exemplary mounting clip for removably attaching panels to a supporting structure comprises a base, spring locking clips, a lateral flange, a lever flange, and a spring bonding pad. The spring locking clips extend upwardly from the base. The lateral flange extends upwardly from a first side of the base. The lateral flange comprises a slot having an opening configured to receive at least a portion of one of the one or more panels. The lever flange extends outwardly from the lateral flange. The spring bonding flange extends downwardly from the lever flange. At least a portion of the first spring bonding flange comprises a serrated edge for gouging at least a portion of the one or more panels when the one or more panels are attached to the mounting clip to electrically and mechanically couple the one or more panels to the mounting clip.

  11. Toll-Like Receptors and Myocardial Inflammation

    Directory of Open Access Journals (Sweden)

    Yan Feng

    2011-01-01

    Full Text Available Toll-like receptors (TLRs are a member of the innate immune system. TLRs detect invading pathogens through the pathogen-associated molecular patterns (PAMPs recognition and play an essential role in the host defense. TLRs can also sense a large number of endogenous molecules with the damage-associated molecular patterns (DAMPs that are produced under various injurious conditions. Animal studies of the last decade have demonstrated that TLR signaling contributes to the pathogenesis of the critical cardiac conditions, where myocardial inflammation plays a prominent role, such as ischemic myocardial injury, myocarditis, and septic cardiomyopathy. This paper reviews the animal data on (1 TLRs, TLR ligands, and the signal transduction system and (2 the important role of TLR signaling in these critical cardiac conditions.

  12. Redefining Death

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The results of 20 years of research on brain death will be released to the public, the Chinese Ministry of Health reported in early April. A special ministry team has drafted the criteria for brain death in Criteria for the Diagnosis of Brain Death in Adults (Revised Edition) and Technical Specifications for the Diagnosis

  13. Mounting power cables on SOLEIL

    CERN Multimedia

    Laurent Guiraud

    1999-01-01

    The power couplers are mounted on the SOLEIL cryomodule in a clean room. The cryomodule will allow superconducting technology to be used at SOLEIL, the French national synchrotron facility. This work is carried out as part of a collaboration between CERN and CEA Saclay, the French National Atomic Energy Commission.

  14. Shock Mounting for Heavy Machines

    Science.gov (United States)

    Thompson, A. R.

    1984-01-01

    Elastomeric bearings eliminate extraneous forces. Rocket thrust transmitted from motor to load cells via support that absorbs extraneous forces so they do not affect accuracy of thrust measurements. Adapter spoked cone fits over forward end of rocket motor. Shock mounting developed for rocket engines under test used as support for heavy machines, bridges, or towers.

  15. Mount St. Helens aerosol evolution

    Energy Technology Data Exchange (ETDEWEB)

    Oberbeck, V.R.; Farlow, N.H.

    1982-08-01

    Stratospheric aerosol samples were collected using a wire impactor during the year following the eruption of Mount St. Helens. Analysis of samples shows that aerosol volume increased for 6 months due to gas-to-particle conversion and then decreased to background levels in the following 6 months.

  16. Control of Wall Mounting Robot

    DEFF Research Database (Denmark)

    Sloth, Christoffer; Pedersen, Rasmus

    2017-01-01

    This paper presents a method for designing controllers for trajectory tracking with actuator constraints. In particular, we consider a joystick-controlled wall mounting robot called WallMo. In contrast to previous works, a model-free approach is taken to the control problem, where the path...

  17. Determining the Toll and Capacity of a Highway to Be Constructed in Parallel with Subway

    Directory of Open Access Journals (Sweden)

    Wen-Xiang Wu

    2014-01-01

    Full Text Available This paper considers the problem of toll and capacity choice of a new highway with a bottleneck added onto an existing transit network under four ownership/tolling regimes: public fine toll, public flat toll, private fine toll, and private flat toll. Whenever fine toll and flat toll are imposed, in a competitive highway/transit network with constant returns to scale in road construction, an optimally designed and priced privately owned highway would produce positive net benefit justly equal to the total markup with respect to all autocommuters, whereas an optimally designed and priced publicly owned highway would lead to a deficit; that is, the toll revenues are insufficient to cover its all costs. The economic conditions to invest a new road are investigated under different ownership/tolling regimes.

  18. Minnesota urban partnership agreement national evaluation : tolling test plan.

    Science.gov (United States)

    2009-11-17

    This report presents the test plan for collecting and analyzing toll data for the Minnesota Urban Partnership : Agreement (UPA) under the United States Department of Transportation (U.S. DOT) UPA Program. The : Minnesota UPA projects focus on reducin...

  19. Disseminated cysticercosis: clinical spectrum, Toll-like receptor-4 gene polymorphisms and role of albendazole

    Science.gov (United States)

    Qavi, Abdul; Garg, Ravindra Kumar; Malhotra, Hardeep Singh; Jain, Amita; Kumar, Neeraj; Malhotra, Kiran Preet; Srivastava, Pradeep Kumar; Verma, Rajesh; Sharma, Praveen Kumar

    2016-01-01

    Abstract In this study, we describe clinical and imaging spectrum, and the natural course of patients with disseminated cysticercosis. How albendazole affects the course of disease has also been evaluated. We assessed the Toll-like receptor-4 gene polymorphisms, to know the reason for the apparently higher prevalence of disseminated cysticercosis in India. Sixty consecutive patients with disseminated cysticercosis were enrolled. Sixty age-and-sex-matched healthy controls were also enrolled for the purpose of genetic study. Twenty patients, who gave consent, were treated with albendazole along with corticosteroids. Forty patients did not give consent for antiparasitic therapy. Assessment for Toll-like receptor-4 gene polymorphisms (Asp299Gly and Thr399Ile genes) was done. Patients were followed for 6 months. We also performed a literature search of cases published in English language using PubMed electronic database and analyzed 56 cases thus available. There was an increased risk (6.63 fold and 4.61 fold) of disseminated cysticercosis in the presence of Asp299Gly and Thr399Ile polymorphisms in Toll-like receptor-4, respectively. The allelic frequency of Gly (11% vs. 3%, P = 0.024, odds ratio [OR] = 3.52) and Ile alleles (11% vs. 2%, P = 0.009, OR = 4.738) in disseminated cysticercosis was high. Albendazole resulted in complete disappearance of all cerebral lesions in 35% (7/20) patients and reduction in lesion load in remaining 65% (13/20) patients. No significant change in number of cysticercal lesion was noted in patients who did not receive albendazole. No major adverse reaction following antiparasitic treatment was noted. Three deaths were recorded in patients who did not receive antiparasitic treatment. Of the 56 cases reported in PubMed, 33 patients received antiparasitic treatment with follow-up data available for 31 patients. Most (24) of these patients received albendazole. A significant clinical and/or imaging improvements, on follow up, were observed in

  20. Tension pneumocephalus: Mount Fuji sign

    Directory of Open Access Journals (Sweden)

    Pulastya Sanyal

    2015-01-01

    Full Text Available A 13-year-old male was operated for a space occupying lesion in the brain. A noncontrast computed tomography scan done in the late postoperative period showed massive subdural air collection causing compression of bilateral frontal lobes with widening of interhemispheric fissure and the frontal lobes acquiring a peak like configuration - causing tension pneumocephalus-"Mount Fuji sign." Tension pneumocephalus occurs when air enters the extradural or intradural spaces in sufficient volume to exert a mass or pressure effect on the brain, leading to brain herniation. Tension pneumocephalus is a surgical emergency, which needs immediate intervention in the form of decompression of the cranial cavity by a burr hole or needle aspiration. The Mount Fuji sign differentiates tension pneumocephalus from pneumocephalus.

  1. Toll-like receptors of deuterostome invertebrates

    Directory of Open Access Journals (Sweden)

    Honoo eSatake

    2012-02-01

    Full Text Available Defensive systems against pathogens are responsible not only for survival or lifetime of an individual but also for the evolution of a species. Innate immunity is expected to be more important for invertebrates than mammals, given that adaptive immunity has not been acquired in the former. Toll-like receptors (TLRs have been shown to play a crucial role in host defense of pathogenic microbes in innate immunity of mammals. Recent genome-wide analyses have suggested that TLR or their related genes are conserved in invertebrates. In particular, numerous TLR-related gene candidates were detected in deuterostome invertebrates including a sea urchin (222 TLR-related gene candidates and amphioxus (72 TLR-related gene candidates. Molecular phylogenetic analysis verified that most of sea urchin or amphioxus TLR candidates are paralogous, suggesting that these organisms expanded TLR-related genes in a species-specific manner. In contrast, another deuterostome invertebrate, an ascidian, Ciona intestinalis, was found to possess only two TLR genes. Moreover, Ciona TLRs, Ci-TLR1 and -2, were shown to possess hybrid functionality of mammalian TLRs. Such functionality of Ci-TLRs could not be predicted by sequence comparison with vertebrate TLRs, indicating the confounding evolutionary lineages of deuterostome invertebrate TLRs or their candidates. In this review article, we present recent advances in studies of TLRs or their candidates of deuterostome invertebrates, and provide insight into an evolutionary process of TLRs.

  2. DMPD: Translational mini-review series on Toll-like receptors: networks regulated byToll-like receptors mediate innate and adaptive immunity. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17223959 Translational mini-review series on Toll-like receptors: networks regulate...ol. 2007 Feb;147(2):199-207. (.png) (.svg) (.html) (.csml) Show Translational mini-review series on Toll-lik... immunity. PubmedID 17223959 Title Translational mini-review series on Toll-like receptors: networks regulat

  3. Mounting support for a photovoltaic module

    Science.gov (United States)

    Brandt, Gregory Michael; Barsun, Stephan K.; Coleman, Nathaniel T.; Zhou, Yin

    2013-03-26

    A mounting support for a photovoltaic module is described. The mounting support includes a foundation having an integrated wire-way ledge portion. A photovoltaic module support mechanism is coupled with the foundation.

  4. Flush Mounting Of Thin-Film Sensors

    Science.gov (United States)

    Moore, Thomas C., Sr.

    1992-01-01

    Technique developed for mounting thin-film sensors flush with surfaces like aerodynamic surfaces of aircraft, which often have compound curvatures. Sensor mounted in recess by use of vacuum pad and materials selected for specific application. Technique involves use of materials tailored to thermal properties of substrate in which sensor mounted. Together with customized materials, enables flush mounting of thin-film sensors in most situations in which recesses for sensors provided. Useful in both aircraft and automotive industries.

  5. Mounting Thin Samples For Electrical Measurements

    Science.gov (United States)

    Matus, L. G.; Summers, R. L.

    1988-01-01

    New method for mounting thin sample for electrical measurements involves use of vacuum chuck to hold a ceramic mounting plate, which holds sample. Contacts on mounting plate establish electrical connection to sample. Used to make electrical measurements over temperature range from 77 to 1,000 K and does not introduce distortions into magnetic field during Hall measurements.

  6. Pipelines update : new tolls and new opportunities in gas gathering

    International Nuclear Information System (INIS)

    Shelton, E.

    1999-01-01

    An overview of the new TransCanada energy transmission system was given. TransCanada has ownership interests in seven other North American natural gas pipelines and the integration of former NOVA Gas Transmission, TransCanada Energy Transmission and ANG Pipeline organizations into a single organization is nearing completion. Integration efforts have been driven by TransCanada's commitment to provide customers with lower costs and improved service levels. The service enhancements will include one-stop shopping, customer advisory councils, harmonized design criteria, optimized operations/maintenance, and consistent billing processes. The new toll design which will replace the current postage-stamp pricing regime offered by NGTL was also reviewed, emphasizing key features such as pricing, term linked tolls, interruptible/short term tolls, renewal incentive, risk/reward collar, transition period and new services

  7. Electronic Toll And Traffic Management Systems, National Cooperative Highway Research Program Synthesis

    Science.gov (United States)

    1993-01-01

    ELECTRONIC TOLL COLLECTION OR ETC AND TRAFFIC MANAGEMENT OR ETTM, AUTOMATIC VEHICLE IDENTIFICATION OR AVI : ELECTRONIC TOLL COLLECTION AND TRAFFIC MANAGEMENT (ETTM) SYSTEMS ARE NOT A FUTURISTIC DREAM, THEY ARE OPERATING OR ARE BEING TESTED TODAY I...

  8. A dynamic feedback-control toll pricing methodology : a case study on Interstate 95 managed lanes.

    Science.gov (United States)

    2013-06-01

    Recently, congestion pricing emerged as a cost-effective and efficient strategy to mitigate the congestion problem on freeways. This study develops a feedback-control based dynamic toll approach to formulate and solve for optimal tolls. The study com...

  9. How a fast lane may replace a congestion toll

    DEFF Research Database (Denmark)

    Fosgerau, Mogens

    2011-01-01

    This paper considers a congested bottleneck. A fast lane reserves a more than proportional share of capacity to a designated group of travellers. Travellers are otherwise identical and other travellers can use the reserved capacity when it would otherwise be idle. The paper shows that such a fast...... welfare improving when demand is elastic....... lane is always Pareto improving under Nash equilibrium in arrival times at the bottleneck and inelastic demand. It can replicate the arrival schedule and queueing outcomes of a toll that optimally charges a constant toll during part of the demand peak. Within some bounds, the fast lane scheme is still...

  10. How a fast lane may replace a congestion toll

    DEFF Research Database (Denmark)

    Fosgerau, Mogens

    This paper considers a congested bottleneck. A fast lane reserves a more than proportional share of capacity to a designated group of travellers. Travellers are otherwise identical and other travellers can use the reserved capacity when it would otherwise be idle. The paper shows that such a fast...... welfare improving when demand is elastic....... lane is always Pareto improving under Nash equilibrium in arrival times at the bottleneck and inelastic demand. It can replicate the arrival schedule and queueing outcomes of a toll that optimally charges a constant toll during part of the demand peak. Within some bounds, the fast lane scheme is still...

  11. The evaluation model of the design of toll

    Science.gov (United States)

    Feng, Shuting

    2018-04-01

    In recent years, the dramatic increase in traffic burden has highlighted the necessity of rational allocation of toll plaza. At the same time, the need to consider a lot of factors has enhanced the design requirements. In this background, we carry out research on this subject. We propose a reasonable assumption, and abstract the toll plaza into a model only related to B and L. By using the queuing theory and traffic flow theory, we define the throughput, cost and accident prevent with B and L to acquire the base model. By using the method of linear weighting in economics to calculate this model, the optimal B and L strategies are obtained.

  12. Local Community Entrepreneurship in Mount Agung Trekking

    Science.gov (United States)

    Mudana, I. G.; Sutama, I. K.; Widhari, C. I. S.

    2018-01-01

    Since its last major eruption in 1963, Mount Agung in Selat District, Karangasem Regency, the highest mountain in Bali Province began to be visited by tourists climbers. Because of the informal obligation that every climbing/trekking should be guided by local guides, since the 1990s, there have been initiatives from a number of local community members to serve climbing tourists who were keen to climb the volcano/mountain. This study was conducted to understand and describe the entrepreneurial practices which appeared in the local surrounding community. Specifically, Selat Village, in guiding the climbing/trekking. This study used qualitative data analysis and its theories were adapted to data needed in the field. The results of study showed that Mount Agung was considered attractive by climbing tourists not only because of the exotic beauty and challenges of difficulty (as well as the level of danger) to conquer it, but also because it kept certain myths from its status as a holy/sacred mountain to Balinese Hindus. In fact, a number of tourists who did the climbing/trekking without being guided very often got lost, harmed in an accident, or fell to their death. As a direct result, all climbing activities require guidance. Especially guides from local community organizations who really understand the intricacies of climbing and the curvature of the mountain. The entrepreneurial practices of Selat Village community had arisen not only to serve usual climbing activities, but also to preserve the environment of the mountain and the safety of the climbing tourists with the many taboos related to the climb. These facts could be seen clearly from descriptions of local experts and local climbing guides who have been doing their work for years. As a form of entrepreneurship, they basically did their work for the main purpose of seeking livelihoods (or making money) but their responsibility as local people made them commit to guarding the sanctity of the mountain. This was

  13. Surviving death

    DEFF Research Database (Denmark)

    Gerstroem, Anna

    2013-01-01

    such phases. The aim of this paper is to explore how an organization’s identity is re-constructed after organizational death. Based on interviews with members of a bankrupted bank who narrate their bankruptcy experiences, the paper explores how legacy organizational identity is constructed after...... organizational death. The paper shows how members draw on their legacy organizational identity to justify their past interpretations and responses to the intensifying bankruptcy threats. Members refer to their firm belief in the bank’s solid and robust identity claim when they explain how they disregarded...

  14. Substantial-Motivational Mechanism for Substantiation of Tolling Operations in Conditions of the European Integration

    OpenAIRE

    Melnyk Olga G; Kots Iryna I.

    2016-01-01

    The article is concerned with conceptualization of substance, distinguishing characteristics and motives of the implementation of tolling operations in conditions of the European integration. The study, based on the systematization and analysis of existing scientific approaches to definition of essence of tolling and tolling operations, has disclosed the dominating poli-positionality and ambiguity in this area. Economical autonomy of tolling operations has been determined, t...

  15. Ocean floor mounting of wave energy converters

    Science.gov (United States)

    Siegel, Stefan G

    2015-01-20

    A system for mounting a set of wave energy converters in the ocean includes a pole attached to a floor of an ocean and a slider mounted on the pole in a manner that permits the slider to move vertically along the pole and rotate about the pole. The wave energy converters can then be mounted on the slider to allow adjustment of the depth and orientation of the wave energy converters.

  16. Mounting and Alignment of IXO Mirror Segments

    Science.gov (United States)

    Chan, Kai-Wing; Zhang, William; Evans, Tyler; McClelland, Ryan; Hong, Melinda; Mazzarella, James; Saha, Timo; Jalota, Lalit; Olsen, Lawrence; Byron, Glenn

    2010-01-01

    A suspension-mounting scheme is developed for the IXO (International X-ray Observatory) mirror segments in which the figure of the mirror segment is preserved in each stage of mounting. The mirror, first fixed on a thermally compatible strongback, is subsequently transported, aligned and transferred onto its mirror housing. In this paper, we shall outline the requirement, approaches, and recent progress of the suspension mount processes.

  17. DMPD: Toll-like receptors regulation of viral infection and disease. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18280610 Toll-like receptors regulation of viral infection and disease. Thompson JM...how Toll-like receptors regulation of viral infection and disease. PubmedID 18280610 Title Toll-like recepto...rs regulation of viral infection and disease. Authors Thompson JM, Iwasaki A. Pub

  18. DMPD: The Toll-like receptors: analysis by forward genetic methods. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 16001129 The Toll-like receptors: analysis by forward genetic methods. Beutler B. I...mmunogenetics. 2005 Jul;57(6):385-92. (.png) (.svg) (.html) (.csml) Show The Toll-like receptors: analysis by forwar...d genetic methods. PubmedID 16001129 Title The Toll-like receptors: analysis by forward genetic meth

  19. DMPD: Viral recognition by Toll-like receptors. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17336545 Viral recognition by Toll-like receptors. Barton GM. Semin Immunol. 2007 F...eb;19(1):33-40. Epub 2007 Mar 2. (.png) (.svg) (.html) (.csml) Show Viral recognition by Toll-like receptors.... PubmedID 17336545 Title Viral recognition by Toll-like receptors. Authors Barton GM. Publication Semin Imm

  20. DMPD: All is not Toll: new pathways in DNA recognition. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 16446382 All is not Toll: new pathways in DNA recognition. Wagner H, Bauer S. J Exp... Med. 2006 Feb 20;203(2):265-8. Epub 2006 Jan 30. (.png) (.svg) (.html) (.csml) Show All is not Toll: new pathways in DNA recognition.... PubmedID 16446382 Title All is not Toll: new pathways in DNA recognition. Authors

  1. DMPD: Modulation of Toll-interleukin 1 receptor mediated signaling. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15662540 Modulation of Toll-interleukin 1 receptor mediated signaling. Li X, Qin J.... J Mol Med. 2005 Apr;83(4):258-66. Epub 2005 Jan 21. (.png) (.svg) (.html) (.csml) Show Modulation of Toll-i...nterleukin 1 receptor mediated signaling. PubmedID 15662540 Title Modulation of Toll-interleukin 1 receptor

  2. DMPD: Endogenous ligands of Toll-like receptors. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15178705 Endogenous ligands of Toll-like receptors. Tsan MF, Gao B. J Leukoc Biol. ...2004 Sep;76(3):514-9. Epub 2004 Jun 3. (.png) (.svg) (.html) (.csml) Show Endogenous ligands of Toll-like re...ceptors. PubmedID 15178705 Title Endogenous ligands of Toll-like receptors. Authors Tsan MF, Gao B. Publicat

  3. DMPD: Role of Toll-like receptor responses for sepsis pathogenesis. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18086373 Role of Toll-like receptor responses for sepsis pathogenesis. Weighardt H,... of Toll-like receptor responses for sepsis pathogenesis. PubmedID 18086373 Title Role of Toll-like receptor... responses for sepsis pathogenesis. Authors Weighardt H, Holzmann B. Publication

  4. Channel uranium-graphite reactor mounting

    International Nuclear Information System (INIS)

    Polushkin, K.K.; Kuznetsov, A.G.; Zheleznyakov, B.N.

    1981-01-01

    According to theoretical principles of general engineering technology the engineering experience of construction-mounting works at the NPP with channel uranium-graphite reactors is systematized. Main parameters and structural features of the 1000 MW channel uranium-graphite reactors are considered. The succession of mounting operations, premounting equipment and pipelines preparation and mounting works technique are described. The most efficient methods of fitting, welding and machining of reactor elements are recommended. Main problems of technical control service are discussed. A typical netted diagram of main equipment of channel uranium-graphite reactors mounting is given

  5. Death cap

    DEFF Research Database (Denmark)

    Rudbæk, Torsten R; Kofoed, Pernille Bouteloup; Bove, Jeppe

    2014-01-01

    Death cap (Amanita phalloides) is commonly found and is one of the five most toxic fungi in Denmark. Toxicity is due to amatoxin, and poisoning is a serious medical condition, causing organ failure with potential fatal outcome. Acknowledgement and clarification of exposure, symptomatic and focused...

  6. "Spectacular Death"

    DEFF Research Database (Denmark)

    Jacobsen, Michael Hviid

    2016-01-01

    be labelled ‘spectacular death’ in which death, dying and mourning have increasingly become spectacles. Moreover, the author proposes that what is currently happening in contemporary Western society can be interpreted as an expression of a ‘partial re-reversal’ of ‘forbidden death’ to some...

  7. Consumer Experiences Calling Toll-Free Corporate Hotlines.

    Science.gov (United States)

    Martin, Charles L.; Smart, Denise T.

    1994-01-01

    Finds that dimensions that contribute to caller satisfaction (of toll-free corporate hotlines) included operator characteristics such as knowledge, courtesy, and interest; specific behaviors such as apologizing for a problem, thanking the consumer for calling, and encouraging them to call again; and reducing time placed on "hold." (SR)

  8. Toll-like receptor-4 (TLR-4) expression on polymorphonuclear ...

    African Journals Online (AJOL)

    To establish a foundation for further researches on the improvement of polymorphonuclear neutrophil leukocytes (PMN) functions in dairy cow during perinatal period, the counting of PMN, as well as the mRNA and protein expression of toll-like receptor-4 (TLR-4) on PMN was studied during this critical period.

  9. 49 CFR 179.10 - Tank mounting.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Tank mounting. 179.10 Section 179.10 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... Design Requirements § 179.10 Tank mounting. (a) The manner in which tanks are attached to the car...

  10. Low-Thermal-Resistance Baseplate Mounting

    Science.gov (United States)

    Perreault, W. T.

    1984-01-01

    Low-thermal-resistance mounting achieved by preloading baseplate to slight convexity with screws threaded through beam. As mounting bolts around edge of base-place tightened, baseplate and cold plate contact first in center, with region of intimate contact spreading outward as bolts tightened.

  11. Mount Athos: Between autonomy and statehood

    Directory of Open Access Journals (Sweden)

    Avramović Dragutin

    2013-01-01

    Full Text Available Legal status of the Mount Athos is characterized by many special features that make it internationally unique legal regime. The author analyzes peculiarities of Mount Athos territorial status, legal position of residents and visitors, as well as organization of Mount Athos authorities. The author concludes that the Mount Athos is characterized by a kind of para-sovereignty. Its autonomy involves not only the internal organization, autonomous governance and religious autonomy, but it also includes many elements of secular life of their visitors. Mount Athos has its own, separate legislative, administrative and judicial powers, while the Statute of the Mount Athos has greater legal force than all the other laws of the Greek state, because the state can not unilaterally change its provisions. Having in mind that the wide self-government is vested in church authorities and that the monks have very specific way of living, the author takes a position that the Mount Athos represent 'monastic state', but without statehood. The author also states that the Mount Athos will be faced with many challenges in the context of spreading of an assimilating, universal conception of human rights.

  12. Dynamically Determining the Toll Plaza Capacity by Monitoring Approaching Traffic Conditions in Real-Time

    Directory of Open Access Journals (Sweden)

    Cheolsun Kim

    2016-03-01

    Full Text Available This study presents an analytical method for dynamically adjusting toll plaza capacity to cope with a sudden shift in demand. The proposed method uses a proxy measure developed using discharge rate observed at toll plazas and segment travel times measured by probe vehicles. The effectiveness of the method has been evaluated by analyzing the empirical data obtained from toll plazas in the San Francisco Bay Area before and after toll plaza capacity changed. Findings indicate that the estimated number of vehicles stored near the upstream of toll plaza based on discharge rate and their travel times can be used as a proxy measure for predicting the effect of changes in toll plaza capacity. The proposed model can aid government agencies to dynamically adjust the toll plaza capacity in response to a sudden shift in demand due to various situations of failure.

  13. For Whom Does Language Death Toll? Cautionary Notes from the Basque Case

    Science.gov (United States)

    Echeverria, Begona

    2010-01-01

    In this article, I show that despite a seemingly inclusive, language-based identity promoted in schools and pedagogical materials, Basque identity and language are embedded with social histories that exclude large swaths of the would-be Basque nation: women and second language learners of Basque. To the extent that these processes continue to…

  14. Drill cuttings mount formation study

    Science.gov (United States)

    Teh, Su Yean; Koh, Hock Lye

    2014-07-01

    Oil, Gas and Energy sector has been identified as an essential driving force in the Malaysian Economic Transformation Programs (ETP). Recently confirmed discovery of many offshore oil and gas deposits in Malaysian waters has ignited new confidence in this sector. However, this has also spurred intense interest on safeguarding the health and environment of coastal waters in Malaysia from adverse impact resulting from offshore oil and gas production operation. Offshore discharge of spent drilling mud and rock cuttings is the least expensive and simplest option to dispose of large volumes of drilling wastes. But this onsite offshore disposal may have adverse environmental impacts on the water column and the seabed. It may also pose occupational health hazards to the workers living in the offshore platforms. It is therefore important to model the transport and deposition of drilling mud and rock cuttings in the sea to enable proper assessment of their adverse impacts on the environment and the workers. Further, accumulation of drill particles on the seabed may impede proper operation of pipelines on the seabed. In this paper, we present an in-house application model TUNA-PT developed to cater to local oil and gas industry needs to simulate the dispersion and mount formation of drill cuttings by offshore oil and gas exploration and production platforms. Using available data on Malaysian coastal waters, simulation analyses project a pile formation on the seabed with a maximum height of about 1 m and pile radius of around 30 to 50 m. Simulated pile heights are not sensitive to the heights of release of the cuttings as the sensitivity has been mitigated by the depth of water.

  15. An improved loopless mounting method for cryocrystallography

    International Nuclear Information System (INIS)

    Jian-Xun, Qi; Fan, Jiang

    2010-01-01

    Based on a recent loopless mounting method, a simplified loopless and bufferless crystal mounting method is developed for macromolecular crystallography. This simplified crystal mounting system is composed of the following components: a home-made glass capillary, a brass seat for holding the glass capillary, a flow regulator, and a vacuum pump for evacuation. Compared with the currently prevalent loop mounting method, this simplified method has almost the same mounting procedure and thus is compatible with the current automated crystal mounting system. The advantages of this method include higher signal-to-noise ratio, more accurate measurement, more rapid flash cooling, less x-ray absorption and thus less radiation damage to the crystal. This method can be extended to the flash-freeing of a crystal without or with soaking it in a lower concentration of cryoprotectant, thus it may be the best option for data collection in the absence of suitable cryoprotectant. Therefore, it is suggested that this mounting method should be further improved and extensively applied to cryocrystallographic experiments. (general)

  16. An improved loopless mounting method for cryocrystallography

    Science.gov (United States)

    Qi, Jian-Xun; Jiang, Fan

    2010-01-01

    Based on a recent loopless mounting method, a simplified loopless and bufferless crystal mounting method is developed for macromolecular crystallography. This simplified crystal mounting system is composed of the following components: a home-made glass capillary, a brass seat for holding the glass capillary, a flow regulator, and a vacuum pump for evacuation. Compared with the currently prevalent loop mounting method, this simplified method has almost the same mounting procedure and thus is compatible with the current automated crystal mounting system. The advantages of this method include higher signal-to-noise ratio, more accurate measurement, more rapid flash cooling, less x-ray absorption and thus less radiation damage to the crystal. This method can be extended to the flash-freeing of a crystal without or with soaking it in a lower concentration of cryoprotectant, thus it may be the best option for data collection in the absence of suitable cryoprotectant. Therefore, it is suggested that this mounting method should be further improved and extensively applied to cryocrystallographic experiments.

  17. Flow distortion on boom mounted cup anemometers

    DEFF Research Database (Denmark)

    Lindelöw, Per Jonas Petter; Friis Pedersen, Troels; Gottschall, Julia

    In this report we investigate on wind direction dependent errors in the measurement of the horizontal wind speed by boom mounted cup anemometers. The boom mounting on the studied lattice tower is performed according to IEC standard design rules, yet, larger deviations than predicted by flow models...... are observed. The errors on the measurements are likely caused by an underestimation of the flow distortions around the tower. In this paper an experimental method for deriving a correction formula and an in-field calibration is suggested. The method is based on measurements with two cup anemometers mounted...

  18. Current Views of Toll-Like Receptor Signaling Pathways

    Directory of Open Access Journals (Sweden)

    Masahiro Yamamoto

    2010-01-01

    Full Text Available On microbial invasion, the host immediately evokes innate immune responses. Recent studies have demonstrated that Toll-like receptors (TLRs play crucial roles in innate responses that lead not only to the clearance of pathogens but also to the efficient establishment of acquired immunity by directly detecting molecules from microbes. In terms of intracellular TLR-mediated signaling pathways, cytoplasmic adaptor molecules containing Toll/IL-1R (TIR domains play important roles in inflammatory immune responses through the production of proinflammatory cytokines, nitric oxide, and type I interferon, and upregulation of costimulatory molecules. In this paper, we will describe our current understanding of the relationship between TLRs and their ligands derived from pathogens such as viruses, bacteria, fungi, and parasites. Moreover, we will review the historical and current literature to describe the mechanisms behind TLR-mediated activation of innate immune responses.

  19. Births and deaths including fetal deaths

    Data.gov (United States)

    U.S. Department of Health & Human Services — Access to a variety of United States birth and death files including fetal deaths: Birth Files, 1968-2009; 1995-2005; Fetal death file, 1982-2005; Mortality files,...

  20. Comparison of Different Toll Policies in the Dynamic Second-best Optimal Toll Design Problem : Case study on a Three-link network

    NARCIS (Netherlands)

    Sta?ková, K.; Olsder, J.J.; Bliemer, M.C.J.

    2009-01-01

    In this paper, the dynamic optimal toll design problem is considered as a one leader-many followers hierarchical non-cooperative game. On a given network the road authority as the leader tolls some links in order to reach its objective, while travelers as followers minimize their perceived travel

  1. Toll-Like Receptors in the Pathogenesis of Autoimmune Diseases

    OpenAIRE

    Mohammad Hosseini, Akbar; Majidi, Jafar; Baradaran, Behzad; Yousefi, Mehdi

    2015-01-01

    Human Toll-like receptors (TLRs) are a family of transmembrane receptors, which play a key role in both innate and adaptive immune responses. Beside of recognizing specific molecular patterns that associated with different types of pathogens, TLRs may also detect a number of self-proteins and endogenous nucleic acids. Activating TLRs lead to the heightened expression of various inflammatory genes, which have a protective role against infection. Data rising predominantly from human patients an...

  2. Substantiation of the road toll for heavy transport vehicles

    OpenAIRE

    Burmaka, N.; Chernykh, A.

    2010-01-01

    The existing and possible additional sources of developing state and local road funds of Ukraine have been considered. The formula for calculating monthly road toll for heavy transport vehicles has been proposed. This formula includes the payment rate per every kilometer of distance, the vehicle capacity utilization factor and the run with the load. The payment rate per every kilometer of distance for transport vehicles depending on the allowed total weight has been substantiated. The given r...

  3. The Aedes aegypti toll pathway controls dengue virus infection.

    Directory of Open Access Journals (Sweden)

    Zhiyong Xi

    2008-07-01

    Full Text Available Aedes aegypti, the mosquito vector of dengue viruses, utilizes its innate immune system to ward off a variety of pathogens, some of which can cause disease in humans. To date, the features of insects' innate immune defenses against viruses have mainly been studied in the fruit fly Drosophila melanogaster, which appears to utilize different immune pathways against different types of viruses, in addition to an RNA interference-based defense system. We have used the recently released whole-genome sequence of the Ae. aegypti mosquito, in combination with high-throughput gene expression and RNA interference (RNAi-based reverse genetic analyses, to characterize its response to dengue virus infection in different body compartments. We have further addressed the impact of the mosquito's endogenous microbial flora on virus infection. Our findings indicate a significant role for the Toll pathway in regulating resistance to dengue virus, as indicated by an infection-responsive regulation and functional assessment of several Toll pathway-associated genes. We have also shown that the mosquito's natural microbiota play a role in modulating the dengue virus infection, possibly through basal-level stimulation of the Toll immune pathway.

  4. Biodiversity of the flora of Mount Papa

    International Nuclear Information System (INIS)

    Yin-Yin-Kyi

    1995-07-01

    Even though Mount Papa is in the dry zone area, it is almost evergreen, due to its elevation of 4981 feet above the sea level and its fertile soil conditions. A has a rich biodiversity with vegetation of many types

  5. May 1980 Mount Saint Helens, USA Images

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — An earthquake occurred at 15 32 UT, only seconds before the explosion that began the eruption of Mount St. Helens volcano. This eruption and blast blew off the top...

  6. Photoelectric panel with equatorial mounting of drive

    Science.gov (United States)

    Kukhta, M. S.; Krauinsh, P. Y.; Krauinsh, D. P.; Sokolov, A. P.; Mainy, S. B.

    2018-03-01

    The relevance of the work is determined by the need to create effective models for sunny energy. The article considers a photoelectric panel equipped with a system for tracking the sun. Efficiency of the system is provided by equatorial mounting, which compensates for the rotation of the Earth by rotating the sunny panel in the plane of the celestial equator. The specificity of climatic and geographical conditions of Tomsk is estimated. The dynamics of power variations of photoelectric panels with equatorial mounting during seasonal fluctuations in Tomsk is calculated. A mobile photovoltaic panel with equatorial mounting of the drive has been developed. The methods of design strategy for placing photovoltaic panels in the architectural environment of the city are presented. Key words: sunny energy, photovoltaics, equatorial mounting, mechatronic model, wave reducer, electric drive.

  7. Isolation Mounting for Charge-Coupled Devices

    Science.gov (United States)

    Goss, W. C.; Salomon, P. M.

    1985-01-01

    CCD's suspended by wires under tension. Remote thermoelectric cooling of charge coupled device allows vibration isolating mounting of CCD assembly alone, without having to suspend entire mass and bulk of thermoelectric module. Mounting hardware simple and light. Developed for charge-coupled devices (CCD's) in infrared telescope support adaptable to sensors in variety of environments, e.g., sensors in nuclear reactors, engine exhausts and plasma chambers.

  8. "Split Cast Mounting: Review and New Technique".

    Science.gov (United States)

    Gundawar, S M; Pande, Neelam A; Jaiswal, Priti; Radke, U M

    2014-12-01

    For the fabrication of a prosthesis, the Prosthodontist meticulously performs all the steps. The laboratory technician then make every effort/strives to perform the remaining lab procedures. However when the processed dentures are remounted on the articulator, some changes are seen. These changes may be divided into two categories: Pre-insertion and post-insertion changes, which deal with the physical properties of the materials involved (Parker, J Prosthet Dent 31:335-342, 1974). Split cast mounting is the method of mounting casts on the articulator. It is essentially a maxillary cast constructed in two parts with a horizontal division. The procedure allows for the verification of the accuracy of the initial mounting and the ease of removal and replacement of the cast. This provides a precise means of correcting the changes in occlusion occurring as a result of the processing technique (Nogueira et al., J Prosthet Dent 91:386-388, 2004). Instability of the split mounting has always been a problem to the Prosthodontist thereby limiting its use. There are various materials mentioned in the literature. The new technique by using Dowel pins and twill thread is very easy, cheaper and simple way to stabilize the split mounting. It is useful and easy in day to day laboratory procedures. The article presents different methods of split cast mounting and the new procedure using easily available materials in prosthetic laboratory.

  9. Analysis of adjusting effects of mounting force on frequency conversion of mounted nonlinear optics.

    Science.gov (United States)

    Su, Ruifeng; Liu, Haitao; Liang, Yingchun; Lu, Lihua

    2014-01-10

    Motivated by the need to increase the second harmonic generation (SHG) efficiency of nonlinear optics with large apertures, a novel mounting configuration with active adjusting function on the SHG efficiency is proposed and mechanically and optically studied. The adjusting effects of the mounting force on the distortion and stress are analyzed by the finite element methods (FEM), as well as the contribution of the distortion and stress to the change in phase mismatch, and the SHG efficiency are theoretically stated. Further on, the SHG efficiency is calculated as a function of the mounting force. The changing trends of the distortion, stress, and the SHG efficiency with the varying mounting force are obtained, and the optimal ones are figured out. Moreover, the mechanism of the occurrence of the optimal values is studied and the adjusting strategy is put forward. Numerical results show the robust adjustment of the mounting force, as well as the effectiveness of the mounting configuration, in increasing the SHG efficiency.

  10. Autophagic components contribute to hypersensitive cell death in Arabidopsis

    DEFF Research Database (Denmark)

    Hofius, Daniel; Schultz-Larsen, Torsten; Joensen, Jan

    2009-01-01

    Autophagy has been implicated as a prosurvival mechanism to restrict programmed cell death (PCD) associated with the pathogen-triggered hypersensitive response (HR) during plant innate immunity. This model is based on the observation that HR lesions spread in plants with reduced autophagy gene...... expression. Here, we examined receptor-mediated HR PCD responses in autophagy-deficient Arabidopsis knockout mutants (atg), and show that infection-induced lesions are contained in atg mutants. We also provide evidence that HR cell death initiated via Toll/Interleukin-1 (TIR)-type immune receptors through...... the defense regulator EDS1 is suppressed in atg mutants. Furthermore, we demonstrate that PCD triggered by coiled-coil (CC)-type immune receptors via NDR1 is either autophagy-independent or engages autophagic components with cathepsins and other unidentified cell death mediators. Thus, autophagic cell death...

  11. Technical preparation of the Yuzhteploehnergomontazh trust for technological equipment mounting

    International Nuclear Information System (INIS)

    Zayats, A.I.

    1982-01-01

    Measures of technical preparation for equipment mounting at the Zaporozhe NPP developed with the Yuzhteploehnergomontazh trust experts are considered. These measures envisage the construction of mounting base of heat facilities, calculation of labour contents and determination of necessary quantity of mounters, development of optimal flowsheet of mounting control, improvement of mounting qualification and creation of stable collective body, improvement of technical level of mounting and welding works, organizational-technical measures on mounting logistics. Factors affecting negatively technical preparation quality of equipment mounting at the Zaporozhe NPP are discussed. The flowsheet of mounting control is presented

  12. Cloning and characterisation of the SpToll gene from green mud crab, Scylla paramamosain.

    Science.gov (United States)

    Lin, Zhongyang; Qiao, Jie; Zhang, Yueling; Guo, Lingling; Huang, He; Yan, Fang; Li, Yuanyou; Wang, Xiuying

    2012-05-01

    Toll/Toll-like receptors (TLRs), one of the most important pattern recognition receptors (PRRs), play a crucial role in innate immune responses in both invertebrates and vertebrates. In this study, we cloned and characterised a Toll gene from Scylla paramamosain (SpToll). Bioinformatic analysis predicted that SpToll contained one open reading frame of 3018bp and encoded a single-pass transmembrane domain protein of 1005 amino acids. Further, SpToll could be clustered into one branch along with other arthropod Tolls in a phylogenetic tree. SpToll transcripts could be detected by RT-PCR from all tissues examined including the heart, gill, hepatopancreas, stomach, intestine, muscle, eyestalk and hemocytes. Infection by Vibrio parahemolyticus up-regulated SpToll mRNA expression in hemocytes after 48h. The profile of single nucleotide polymorphisms (SNPs) in the leucine-rich repeats (LRRs) domain of SpToll in three healthy crabs was then evaluated. Two hundred and twenty SNPs with a frequency of about 1.0-4.0% were identified in hemocyte DNA/cDNA. Surprisingly, the adenine to guanine transition at position 1372 (c.1372A>G) had a frequency of about 50%. Finally, the results showed that challenge with V. parahemolyticus stimulated the appearance of two sets of SNPs in crabs. More importantly, the c.1372A>G mutation could contribute to a low mortality after V. parahemolyticus infection and introduce variation of charge and secondary structure into the SpToll polypeptide. In summary, these studies suggested a novel Toll homologue in crab and identified a SNP with potential pathogen-resistant activities. The result will be important for the investigation of crab immune defense mechanisms. Copyright © 2011 Elsevier Ltd. All rights reserved.

  13. Toll-Like Receptor-3 and Geographic Atrophy in Age-Related Macular Degeneration

    Science.gov (United States)

    Yang, Zhenglin; Stratton, Charity; Francis, Peter J.; Kleinman, Mark E.; Tan, Perciliz L.; Gibbs, Daniel; Tong, Zongzhong; Chen, Haoyu; Constantine, Ryan; Yang, Xian; Chen, Yuhong; Zeng, Jiexi; Davey, Lisa; Ma, Xiang; Hau, Vincent S.; Wang, Chi; Harmon, Jennifer; Buehler, Jeanette; Pearson, Erik; Patel, Shrena; Kaminoh, Yuuki; Watkins, Scott; Luo, Ling; Zabriskie, Norman A.; Bernstein, Paul S.; Cho, Wongil; Schwager, Andrea; Hinton, David R; Klein, Michael L; Hamon, Sara C.; Simmons, Emily; Yu, Beifeng; Campochiaro, Betsy; Sunness, Janet S.; Campochiaro, Peter; Jorde, Lynn; Parmigiani, Giovanni; Zack, Donald J.; Katsanis, Nicholas; Ambati, Jayakrishna; Zhang, Kang

    2008-01-01

    BACKGROUND Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment in the developed world. Advanced AMD is comprised of geographic atrophy (GA) and choroidal neovascularization (CNV). Specific genetic variants that predispose for GA are largely unknown. METHODS We tested (i) for association between the functional toll-like receptor-3 (TLR3) variant rs3775291 (L412F) and AMD in European Americans and (ii) the effect of TLR3 L and F variants on the viability of human retinal pigment epithelium (RPE) cells in vitro and on RPE cell apoptosis in wildtype and Tlr3−/− mice. RESULTS The F variant (or T allele at single nucleotide polymorphism at rs3775291) was associated with protection against GA (P=0.005); this association was replicated in two independent GA case-control series (P=5.43×10−4 and P=0.002, respectively. We observed no association between TLR3 variants and CNV. The rs377291 variant is probably critical to the function of TLR3, because a prototypic TLR3 ligand induced cell death and apoptosis in human RPE cells with the LL genotype to a greater extent than it did RPE cells with the LF genotype. Moreover, the ligand induced more RPE cell death and apoptosis in wild-type than in Tlr3−/− mice. CONCLUSIONS The TLR3 412F variant confers protection against GA, probably by suppressing RPE cell death. Given that double stranded RNA can activate TLR3-mediated apoptosis, our results suggest a possible role for viral dsRNA transcripts in the development of GA and raise awareness of potential toxicity induced by short interfering RNA (siRNA) therapeutics in the eye. PMID:18753640

  14. Drosophila Ninjurin A induces nonapoptotic cell death.

    Directory of Open Access Journals (Sweden)

    Sarah Broderick

    Full Text Available Ninjurins are conserved transmembrane proteins that are upregulated across species in response to injury and stress. Their biological functions are not understood, in part because there have been few in vivo studies of their function. We analyzed the expression and function of one of three Drosophila Ninjurins, NijA. We found that NijA protein is redistributed to the cell surface in larval immune tissues after septic injury and is upregulated by the Toll pathway. We generated a null mutant of NijA, which displayed no detectable phenotype. In ectopic expression studies, NijA induced cell death, as evidenced by cell loss and acridine orange staining. These dying cells did not display hallmarks of apoptotic cells including TUNEL staining and inhibition by p35, indicating that NijA induced nonapoptotic cell death. In cell culture, NijA also induced cell death, which appeared to be cell autonomous. These in vivo studies identify a new role for the Ninjurin family in inducing nonapoptotic cell death.

  15. 76 FR 76689 - Cibola National Forest, Mount Taylor Ranger District, NM, Mount Taylor Combined Exploratory Drilling

    Science.gov (United States)

    2011-12-08

    ... National Forest, Mount Taylor Ranger District, NM, Mount Taylor Combined Exploratory Drilling AGENCY... proposed action is to approve two Plans of Operations for exploratory uranium drilling on the Cibola... San Mateo. In total, there are up to 279 drill holes that would be drilled over a period not to exceed...

  16. Ball mounting fixture for a roundness gage

    Science.gov (United States)

    Gauler, Allen L.; Pasieka, Donald F.

    1983-01-01

    A ball mounting fixture for a roundness gage is disclosed. The fixture includes a pair of chuck assemblies oriented substantially transversely with respect to one another and mounted on a common base. Each chuck assembly preferably includes a rotary stage and a wobble plate affixed thereto. A ball chuck affixed to each wobble plate is operable to selectively support a ball to be measured for roundness, with the wobble plate permitting the ball chuck to be tilted to center the ball on the axis of rotation of the rotary stage. In a preferred embodiment, each chuck assembly includes a vacuum chuck operable to selectively support the ball to be measured for roundness. The mounting fixture enables a series of roundness measurements to be taken with a conventional rotating gagehead roundness instrument, which measurements can be utilized to determine the sphericity of the ball.

  17. Mounting system for optical frequency reference cavities

    Science.gov (United States)

    Notcutt, Mark (Inventor); Hall, John L. (Inventor); Ma, Long-Sheng (Inventor)

    2008-01-01

    A technique for reducing the vibration sensitivity of laser-stabilizing optical reference cavities is based upon an improved design and mounting method for the cavity, wherein the cavity is mounted vertically. It is suspended at one plane, around the spacer cylinder, equidistant from the mirror ends of the cavity. The suspension element is a collar of an extremely low thermal expansion coefficient material, which surrounds the spacer cylinder and contacts it uniformly. Once the collar has been properly located, it is cemented in place so that the spacer cylinder is uniformly supported and does not have to be squeezed at all. The collar also includes a number of cavities partially bored into its lower flat surface, around the axial bore. These cavities are support points, into which mounting base pins will be inserted. Hence the collar is supported at a minimum of three points.

  18. 14 CFR 33.23 - Engine mounting attachments and structure.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Engine mounting attachments and structure... mounting attachments and structure. (a) The maximum allowable limit and ultimate loads for engine mounting attachments and related engine structure must be specified. (b) The engine mounting attachments and related...

  19. Robotic mounting of ATLAS barrel SCT modules

    International Nuclear Information System (INIS)

    Nickerson, R.B.; Viehhauser, G.; Wastie, R.; Terada, S.; Unno, Y.; Kohriki, T.; Ikegami, Y.; Hara, K.; Kobayashi, H.; Barbier, G.; Clark, A.G.; Perrin, E.; Carter, A.A.; Mistry, J.; Morris, J.

    2006-01-01

    The 2112 silicon detector modules of the barrel part of the ATLAS SemiConductor Tracker (SCT) have been mounted on their carbon fibre support structure. Module insertion, placement and fixing were performed by robotic assembly tooling. We report on our experience with this assembly method. Part of the mounting sequence involves a partial survey of elements of the support structure which is needed to align the modules properly during insertion. An analysis of these data is used to estimate the positional accuracy of the robots

  20. Sensor mount assemblies and sensor assemblies

    Science.gov (United States)

    Miller, David H [Redondo Beach, CA

    2012-04-10

    Sensor mount assemblies and sensor assemblies are provided. In an embodiment, by way of example only, a sensor mount assembly includes a busbar, a main body, a backing surface, and a first finger. The busbar has a first end and a second end. The main body is overmolded onto the busbar. The backing surface extends radially outwardly relative to the main body. The first finger extends axially from the backing surface, and the first finger has a first end, a second end, and a tooth. The first end of the first finger is disposed on the backing surface, and the tooth is formed on the second end of the first finger.

  1. Commentary: Pursuing justice in death penalty trials.

    Science.gov (United States)

    Watson, Clarence; Eth, Spencer; Leong, Gregory B

    2012-01-01

    The capital trial, by its nature, is fraught with emotionally disturbing elements that jurors must face when deciding the ultimate fate of a guilty defendant. A confluence of mitigating and aggravating factors influences a capital jury's decision to impose a sentence of death. The presence or absence of defendant remorse in these cases may make all the difference in whether a capital defendant's life is spared. This commentary examines the onerous emotional toll encountered by capital jurors in light of the findings of Corwin and colleagues regarding defendant remorse and juror's need for affect. The commentary also presents practical and ethics-related considerations that should be kept in mind when reflecting on their study.

  2. Increased Male-Male Mounting Behaviour in Desert Locusts during Infection with an Entomopathogenic Fungus.

    Science.gov (United States)

    Clancy, Lisa M; Cooper, Amy L; Griffith, Gareth W; Santer, Roger D

    2017-07-18

    Same-sex sexual behaviour occurs across diverse animal taxa, but adaptive explanations can be difficult to determine. Here we investigate male-male mounting (MMM) behaviour in female-deprived desert locust males infected with the entomopathogenic fungus Metarhizium acridum. Over a four-week period, infected locusts performed more MMM behaviours than healthy controls. Among infected locusts, the probability of MMM, and the duration of time spent MMM, significantly increased with the mounting locust's proximity to death. In experimental trials, infected locusts were also significantly more likely than controls to attempt to mount healthy males. Therefore, we demonstrate that MMM is more frequent among infected than healthy male locusts, and propose that this may be explained by terminal reproductive effort and a lowered mate acceptance threshold in infected males. However, during experimental trials mounting attempts were more likely to be successful if the mounted locusts were experimentally manipulated to have a reduced capacity to escape. Thus, reduced escape capability resulting from infection may also contribute to the higher frequency of MMM among infected male locusts. Our data demonstrate that pathogen infection can affect same-sex sexual behaviour, and suggest that the impact of such behaviours on host and pathogen fitness will be a novel focus for future research.

  3. Energetics of Endotoxin Recognition in the Toll-Like Receptor 4 Innate Immune Response.

    Science.gov (United States)

    Paramo, Teresa; Tomasio, Susana M; Irvine, Kate L; Bryant, Clare E; Bond, Peter J

    2015-12-09

    Bacterial outer membrane lipopolysaccharide (LPS) potently stimulates the mammalian innate immune system, and can lead to sepsis, the primary cause of death from infections. LPS is sensed by Toll-like receptor 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variations in LPS can profoundly modulate the response. To better understand the mechanism of LPS-induced stimulation and bacterial evasion, we have calculated the binding affinity to MD-2 of agonistic and antagonistic LPS variants including lipid A, lipid IVa, and synthetic antagonist Eritoran, and provide evidence that the coreceptor is a molecular switch that undergoes ligand-induced conformational changes to appropriately activate or inhibit the receptor complex. The plasticity of the coreceptor binding cavity is shown to be essential for distinguishing between ligands, whilst similar calculations for a model bacterial LPS bilayer reveal the "membrane-like" nature of the protein cavity. The ability to predict the activity of LPS variants should facilitate the rational design of TLR4 therapeutics.

  4. Placental Trophoblast Responses to Porphyromonas gingivalis Mediated by Toll-like Receptor-2 and -4

    Directory of Open Access Journals (Sweden)

    Banun Kusumawardani

    2013-09-01

    Full Text Available Trophoblast participates in preventing allorecognition and controlling pathogens that compromise fetal wellbeing. Toll-like receptors recognize conserved sequences on the pathogens surface and trigger effector cell functions. Porphyromonas gingivalis is thought to spread to the umbilical cord and cause fetal growth restriction. Objective: To characterize expression and function of TLR-2 and TLR-4 in trophoblast cells from Porphyromonas gingivalisinfected pregnant rats. Methods: Live Porphyromonas gingivalis were challenged into the maxillary first molar subgingival sulcus of female rats before and/or during pregnancy and sacrified on gestational day (GD 14 and 20. Porphyromonas gingivalis was detected by API-ZYM system in the maternal blood of the retro-orbital venous plexus and the umbilical cord. TLR-2 and TLR-4 expressions in trophoblast cells was detected by immunohistochemistry. Results: Porphyromonas gingivalis was first detected in the maternal blood and finally spread to the umbilical cord. Syncytiotrophoblast, spongitrophoblast and trophoblastic giant cell in treated groups had significantly higher expression of TLR-2 and TLR-4 than control group (p<0.05. Conclusion: Syncytiotrophoblast, spongitrophoblast and trophoblastic giant cell are able to recognize Porphyromonas gingivalis through TLR-2 and TLR-4 expression. The ligation of TLR-2 and TLR-4 promoted cytokine production and induced trophoblast cell death. These findings strengthen links between periodontal disease and fetal growth restriction.DOI: 10.14693/jdi.v20i2.150

  5. An electrochemical lipopolysaccharide sensor based on an immobilized Toll-Like Receptor-4.

    Science.gov (United States)

    Mayall, R M; Renaud-Young, M; Chan, N W C; Birss, V I

    2017-01-15

    Infections affect millions of people each year and yet methods to ascertain their cause can take more than 24h to be effective. This delay between the presentation with symptoms and the ability to make an informed decision about treatment can have adverse consequences, including death in severe cases. Additionally, pathogen identification is a concern for public safety amid the growing threat of bioterrorism. Developing a detection system based on the immune system offers the advantage of broad specificity, while still remaining pertinent to human health. In this work, human Toll-Like Receptor-4 (TLR-4), a protein responsible for detecting lipopolysaccharide (LPS) of Gram-negative bacteria, was immobilized on both a large area and micro gold electrode via the tethering interaction of a modified Self-Assembled Monolayer (mSAM). In response to varying concentrations of its target, the protein-electrode combination showed a logarithmically proportional increased resistance to charge transfer from a solution-based redox probe, due to the formation of TLR-4 protein dimers. It also demonstrated excellent sensitivity to trace levels of Gram-negative bacteria, while remaining insensitive to both Gram-positive and viral challenges. Further characterization of our mSAM revealed that maintaining the appropriate receptor orientation on the electrode surface, mimicking TLR-4's role in a cellular context, was essential in producing a responsive sensor. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. DMPD: Nuclear factor-kappaB: activation and regulation during toll-like receptorsignaling. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17349209 Nuclear factor-kappaB: activation and regulation during toll-like receptorsignaling. Carmody...uclear factor-kappaB: activation and regulation during toll-like receptorsignaling. Authors Carmody

  7. Simulation-Based Testbed Development for Analyzing Toll Impacts on Freeway Travel

    Science.gov (United States)

    2012-06-01

    Traffic congestion has been a world-wide problem in metropolitan areas all over the world. Toll-based traffic management is one of the most applicable solutions against freeway congestion. This research chooses two toll roads, the SR-167 HOT Lane and...

  8. Expressions of toll-like receptors 2 and 4, and relative cellular ...

    African Journals Online (AJOL)

    Purpose: To investigate the expressions of toll-like receptor 2 (TLR2), toll-like receptor 4 (TLR4), tumor necrosis factor alpha (TNF-α), IFN-γ (IFN- gamma), interleukin 2 (IL-2), interleukin 6 (IL-6) and interleukin 10 (IL-10) in human immunodeficiency virus (HIV) patients with tuberculosis (TB) infection. Methods: Two groups of ...

  9. Stimulation of the innate immune system of carp: role of Toll-like receptors

    NARCIS (Netherlands)

    Pietretti, D.

    2013-01-01

    Toll-like receptors (TLRs), named after the Toll gene identified in fruit flies, are a family of evolutionary conserved proteins that play a key role in the innate immune system. TLRs are found inside or on the surface of immune cells of virtually all-living animals and recognize integral parts

  10. DMPD: Toll-like receptors and Type I interferons. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available m. 2007 May 25;282(21):15319-23. Epub 2007 Mar 29. (.png) (.svg) (.html) (.csml) Show Toll-like receptors and Type I interferons. Pub...medID 17395581 Title Toll-like receptors and Type I interferons. Authors Uematsu S,

  11. DMPD: Interferon gene regulation: not all roads lead to Tolls. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 16095970 Interferon gene regulation: not all roads lead to Tolls. Jefferies CA, Fit...zgerald KA. Trends Mol Med. 2005 Sep;11(9):403-11. (.png) (.svg) (.html) (.csml) Show Interferon gene regulation: not all roads... lead to Tolls. PubmedID 16095970 Title Interferon gene regulation: not all roads lead to

  12. Fixture For Mounting A Pressure Sensor

    Science.gov (United States)

    Cagle, Christopher M.

    1995-01-01

    Fixture for mounting pressure sensor in aerodynamic model simplifies task of removal and replacement of sensor in event sensor becomes damaged. Makes it unnecessary to dismantle model. Also minimizes any change in aerodynamic characteristics of model in event of replacement. Removable pressure sensor installed in fixture in wall of model. Wires from sensor pass through channel under surface.

  13. Creating Gaze Annotations in Head Mounted Displays

    DEFF Research Database (Denmark)

    Mardanbeigi, Diako; Qvarfordt, Pernilla

    2015-01-01

    To facilitate distributed communication in mobile settings, we developed GazeNote for creating and sharing gaze annotations in head mounted displays (HMDs). With gaze annotations it possible to point out objects of interest within an image and add a verbal description. To create an annota- tion...

  14. Flush-mounting technique for composite beams

    Science.gov (United States)

    Harman, T. C.; Kay, B. F.

    1980-01-01

    Procedure permits mounting of heavy parts to surface of composite beams without appreciably weakening beam web. Web is split and held apart in region where attachment is to be made by lightweight precast foam filler. Bolt hole penetrates foam rather than web, and is secured by barrelnut in transverse bushing through web.

  15. Bearing-Mounting Concept Accommodates Thermal Expansion

    Science.gov (United States)

    Nespodzany, Robert; Davis, Toren S.

    1995-01-01

    Pins or splines allow radial expansion without slippage. Design concept for mounting rotary bearing accommodates differential thermal expansion between bearing and any structure(s) to which bearing connected. Prevents buildup of thermal stresses by allowing thermal expansion to occur freely but accommodating expansion in such way not to introduce looseness. Pin-in-slot configuration also maintains concentricity.

  16. Motion planning for gantry mounted manipulators

    DEFF Research Database (Denmark)

    Olsen, Anders Lau; Petersen, Henrik Gordon

    2007-01-01

    We present a roadmap based planner for finding robot motions for gantry mounted manipulators for a line welding application at Odense Steel Shipyard (OSS). The robot motions are planned subject to constraints on when the gantry may be moved. We show that random sampling of gantry configurations...

  17. Photovoltaic module mounting clip with integral grounding

    Science.gov (United States)

    Lenox, Carl J.

    2010-08-24

    An electrically conductive mounting/grounding clip, usable with a photovoltaic (PV) assembly of the type having an electrically conductive frame, comprises an electrically conductive body. The body has a central portion and first and second spaced-apart arms extending from the central portion. Each arm has first and second outer portions with frame surface-disrupting element at the outer portions.

  18. Mounting LHCb hadron calorimeter scintillating tiles

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    Scintillating tiles are carefully mounted in the hadronic calorimeter for the LHCb detector. These calorimeters measure the energy of particles that interact via the strong force, called hadrons. The detectors are made in a sandwich-like structure where these scintillator tiles are placed between metal sheets.

  19. Solidly Mounted Resonator with Optimized Acoustic Reflector

    NARCIS (Netherlands)

    Jose, Sumy; Jansman, Andreas; Hueting, Raymond Josephus Engelbart

    2009-01-01

    The quality factor (Q) of the Solidly Mounted Resonator is limited by acoustic losses caused by waves leaking through the mirror stack. Traditionally employed acoustic mirror reflects only longitudinal waves and not shear waves. Starting with the stop-band theory and the principle of spacer layers

  20. Dynamic characteristics of mirrors' kinematic mount

    International Nuclear Information System (INIS)

    Wu Wenkai; Du Qiang; Li Jingze; Chen Gang; Chen Xiaojuan; Xu Yuanli

    2002-01-01

    Applying exact constrain design principles, kinematic mount for precision positioning large aperture mirrors is designed; theoretical method is introduced to analyze its dynamic characteristics and the result of the experiment for mirrors, stability; accordingly, the methods to improve design are put forward

  1. Making sense of Mount St. Helens

    Science.gov (United States)

    Steve Nash

    2010-01-01

    The eruption of Mount St. Helens in 1980 resulted in "a grand experiment that you could never have gotten anybody to fund," says Forest Service ecologist Charles Crisafulli. "Everything's new. It's a new landform." Unlike most misbehaving volcanoes, this one provided an accessible laboratory right along the Interstate-5 corridor, with the...

  2. June 1992 Mount Spurr, USA Images

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Following 39 years of inactivity, Crater Peak vent on the south flank of Mount Spurr volcano burst into eruption at 7:04 a.m. Alaska daylight time (ADT) on June 27,...

  3. 49 CFR 587.19 - Mounting.

    Science.gov (United States)

    2010-10-01

    ... Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) DEFORMABLE BARRIERS Offset Deformable Barrier § 587.19 Mounting. (a) The deformable face is rigidly attached to the edge of the fixed rigid barrier or to some rigid...

  4. DMPD: Translational mini-review series on Toll-like receptors: recent advances inunderstanding the role of Toll-like receptors in anti-viral immunity. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17223961 Translational mini-review series on Toll-like receptors: recent advances i...147(2):217-26. (.png) (.svg) (.html) (.csml) Show Translational mini-review series on Toll-like receptors: r...nity. PubmedID 17223961 Title Translational mini-review series on Toll-like receptors: recent advances inund

  5. Solution structure of the isolated Pelle death domain.

    Science.gov (United States)

    Moncrieffe, Martin C; Stott, Katherine M; Gay, Nicholas J

    2005-07-18

    The interaction between the death domains (DDs) of Tube and the protein kinase Pelle is an important component of the Toll pathway. Published crystallographic data suggests that the Pelle-Tube DD interface is plastic and implies that in addition to the two predominant Pelle-Tube interfaces, a third interaction is possible. We present the NMR solution structure of the isolated death domain of Pelle and a study of the interaction between the DDs of Pelle and Tube. Our data suggests the solution structure of the isolated Pelle DD is similar to that of Pelle DD in complex with Tube. Additionally, they suggest that the plasticity observed in the crystal structure may not be relevant in the functioning death domain complex.

  6. Infrared vision for the nondestructive inspection of the historic Dery Bridge toll panel

    International Nuclear Information System (INIS)

    Ibarra-Castanedo, C.; Cloutier, I.; Gagne, S.; Maldague, X.

    2015-01-01

    The Dery Gorge holds one of the first toll bridges in Quebec that was in effect from the construction of the bridge in 1804 to be finally abolished in 1910. The toll pricing was indicated on a wooden panel, which was originally installed on the bridge's toll keeper's house, In its present condition this panel shows the toll rates in French and English corresponding to the last period during which the toll was in operation (c.1860-1870), Nevertheless, some indications of older inscriptions can also be partially seen. The main goal of this work was to improve the visibility of the hidden inscriptions by exploring two infrared vision techniques: infrared reflectography and infrared thermography. (author)

  7. Infrared vision for the nondestructive inspection of the historic Dery Bridge toll panel

    Energy Technology Data Exchange (ETDEWEB)

    Ibarra-Castanedo, C. [Laval Univ., Dept. of Electrical and Computer Engineering, Computer Vision and Systems Lab., Laval, Quebec (Canada); Cloutier, I.; Gagne, S. [Centre de conservation du Quebec, Quebec (Canada); Maldague, X. [Laval Univ., Dept. of Electrical and Computer Engineering, Computer Vision and Systems Lab., Laval, Quebec (Canada)

    2015-03-15

    The Dery Gorge holds one of the first toll bridges in Quebec that was in effect from the construction of the bridge in 1804 to be finally abolished in 1910. The toll pricing was indicated on a wooden panel, which was originally installed on the bridge's toll keeper's house, In its present condition this panel shows the toll rates in French and English corresponding to the last period during which the toll was in operation (c.1860-1870), Nevertheless, some indications of older inscriptions can also be partially seen. The main goal of this work was to improve the visibility of the hidden inscriptions by exploring two infrared vision techniques: infrared reflectography and infrared thermography. (author)

  8. DMPD: Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17667936 Structure, function and regulation of the Toll/IL-1 receptor adaptor prote... (.svg) (.html) (.csml) Show Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins. ...PubmedID 17667936 Title Structure, function and regulation of the Toll/IL-1 recep

  9. DMPD: The negative regulation of Toll-like receptor and associated pathways. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17621314 The negative regulation of Toll-like receptor and associated pathways. Lan...) Show The negative regulation of Toll-like receptor and associated pathways. PubmedID 17621314 Title The ne...gative regulation of Toll-like receptor and associated pathways. Authors Lang T,

  10. DMPD: Toll-like receptors: novel pharmacological targets for the treatment ofneurological diseases. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17974478 Toll-like receptors: novel pharmacological targets for the treatment ofneu...png) (.svg) (.html) (.csml) Show Toll-like receptors: novel pharmacological targets for the treatment ofneur...ological diseases. PubmedID 17974478 Title Toll-like receptors: novel pharmacological target

  11. DMPD: The role of Toll-like receptors and Nod proteins in bacterial infection. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15476921 The role of Toll-like receptors and Nod proteins in bacterial infection. P...of Toll-like receptors and Nod proteins in bacterial infection. PubmedID 15476921 Title The role of Toll-like receptors and Nod prote...ins in bacterial infection. Authors Philpott DJ, Girardi

  12. DMPD: Proximal effects of Toll-like receptor activation in dendritic cells. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17142025 Proximal effects of Toll-like receptor activation in dendritic cells. Watt...) (.svg) (.html) (.csml) Show Proximal effects of Toll-like receptor activation in dendritic cells. PubmedID... 17142025 Title Proximal effects of Toll-like receptor activation in dendritic ce

  13. DMPD: Innate immunity and toll-like receptors: clinical implications of basic scienceresearch. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15069387 Innate immunity and toll-like receptors: clinical implications of basic science...te immunity and toll-like receptors: clinical implications of basic scienceresearch. PubmedID 15069387 Title... Innate immunity and toll-like receptors: clinical implications of basic sciencer

  14. DMPD: Toll-like receptors: paving the path to T cell-driven autoimmunity? [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17888644 Toll-like receptors: paving the path to T cell-driven autoimmunity? Marsla... Toll-like receptors: paving the path to T cell-driven autoimmunity? PubmedID 17888644 Title Toll-like recep...tors: paving the path to T cell-driven autoimmunity? Authors Marsland BJ, Kopf M.

  15. Shoulder-Mounted Robot for MRI-guided arthrography: Accuracy and mounting study.

    Science.gov (United States)

    Monfaredi, R; Wilson, E; Sze, R; Sharma, K; Azizi, B; Iordachita, I; Cleary, K

    2015-08-01

    A new version of our compact and lightweight patient-mounted MRI-compatible 4 degree-of-freedom (DOF) robot for MRI-guided arthrography procedures is introduced. This robot could convert the traditional two-stage arthrography procedure (fluoroscopy-guided needle insertion followed by a diagnostic MRI scan) to a one-stage procedure, all in the MRI suite. The results of a recent accuracy study are reported. A new mounting technique is proposed and the mounting stability is investigated using optical and electromagnetic tracking on an anthropomorphic phantom. Five volunteer subjects including 2 radiologists were asked to conduct needle insertion in 4 different random positions and orientations within the robot's workspace and the displacement of the base of the robot was investigated during robot motion and needle insertion. Experimental results show that the proposed mounting method is stable and promising for clinical application.

  16. Systems and methods for mirror mounting with minimized distortion

    Science.gov (United States)

    Antonille, Scott R. (Inventor); Wallace, Thomas E. (Inventor); Content, David A. (Inventor); Wake, Shane W. (Inventor)

    2012-01-01

    A method for mounting a mirror for use in a telescope includes attaching the mirror to a plurality of adjustable mounts; determining a distortion in the mirror caused by the plurality adjustable mounts, and, if the distortion is determined to be above a predetermined level: adjusting one or more of the adjustable mounts; and determining the distortion in the mirror caused by the adjustable mounts; and in the event the determined distortion is determined to be at or below the predetermined level, rigidizing the adjustable mounts.

  17. Increased earthquake safety through optimised mounting concept

    International Nuclear Information System (INIS)

    Kollmann, Dieter; Senechal, Holger

    2013-01-01

    Since Fukushima, there has been intensive work on earthquake safety in all nuclear power plants. A large part of these efforts aim at the earthquake safety of safety-relevant pipeline systems. The problem with earthquake safety here is not the pipeline system itself but rather its mountings and connections to components. This is precisely the topic that the KAE dealt with in years of research and development work. It has developed an algorithm that determines the optimal mounting concept with a few iteration steps depending on arbitrary combinations of loading conditions whilst maintaining compliance with relevant regulations for any pipeline systems. With this tool at hand, we are now in a position to plan and realise remedial measures accurately with minimum time and hardware expenditure, and so distinctly improve the earthquake safety of safety-relevant systems. (orig.)

  18. Micro-inverter solar panel mounting

    Science.gov (United States)

    Morris, John; Gilchrist, Phillip Charles

    2016-02-02

    Processes, systems, devices, and articles of manufacture are provided. Each may include adapting micro-inverters initially configured for frame-mounting to mounting on a frameless solar panel. This securement may include using an adaptive clamp or several adaptive clamps secured to a micro-inverter or its components, and using compressive forces applied directly to the solar panel to secure the adaptive clamp and the components to the solar panel. The clamps can also include compressive spacers and safeties for managing the compressive forces exerted on the solar panels. Friction zones may also be used for managing slipping between the clamp and the solar panel during or after installation. Adjustments to the clamps may be carried out through various means and by changing the physical size of the clamps themselves.

  19. Toll-Like Receptors in the Pathogenesis of Autoimmune Diseases

    Science.gov (United States)

    Mohammad Hosseini, Akbar; Majidi, Jafar; Baradaran, Behzad; Yousefi, Mehdi

    2015-01-01

    Human Toll-like receptors (TLRs) are a family of transmembrane receptors, which play a key role in both innate and adaptive immune responses. Beside of recognizing specific molecular patterns that associated with different types of pathogens, TLRs may also detect a number of self-proteins and endogenous nucleic acids. Activating TLRs lead to the heightened expression of various inflammatory genes, which have a protective role against infection. Data rising predominantly from human patients and animal models of autoimmune disease indicate that, inappropriate triggering of TLR pathways by exogenous or endogenous ligands may cause the initiation and/or perpetuation of autoimmune reactions and tissue damage. Given their important role in infectious and non-infectious disease process, TLRs and its signaling pathways emerge as appealing targets for therapeutics. In this review, we demonstrate how TLRs pathways could be involved in autoimmune disorders and their therapeutic application. PMID:26793605

  20. Toll-like receptors as targets for immune disorders.

    LENUS (Irish Health Repository)

    Keogh, Brian

    2012-02-01

    Since the identification of the first Toll-like receptor (TLR) in humans in 1997, understanding of the molecular basis for innate immunity has increased significantly. The TLR family and downstream signalling pathways have been extensively characterised, There is now significant evidence suggesting a role for TLRs in human inflammatory and immune diseases such as rheumatoid arthritis, diabetes, allergy\\/asthma and atherosclerosis. Various approaches have been taken to identify novel therapeutic agents targeting TLRs including biologics, small molecules and nucleic acid-based drugs. Several are now being evaluated in the clinic and showing promise against various diseases. This review paper outlines the recent advances in the understanding of TLR biology and highlights novel TLR agonists and antagonists in development for the treatment of immune diseases.

  1. Novel drugs targeting Toll-like receptors for antiviral therapy.

    Science.gov (United States)

    Patel, Mira C; Shirey, Kari Ann; Pletneva, Lioubov M; Boukhvalova, Marina S; Garzino-Demo, Alfredo; Vogel, Stefanie N; Blanco, Jorge Cg

    2014-09-01

    Toll-like receptors (TLRs) are sentinel receptors of the host innate immune system that recognize conserved 'pathogen-associated molecular patterns' of invading microbes, including viruses. The activation of TLRs establishes antiviral innate immune responses and coordinates the development of long-lasting adaptive immunity in order to control viral pathogenesis. However, microbe-induced damage to host tissues may release 'danger-associated molecular patterns' that also activate TLRs, leading to an overexuberant inflammatory response and, ultimately, to tissue damage. Thus, TLRs have proven to be promising targets as therapeutics for the treatment of viral infections that result in inflammatory damage or as adjuvants in order to enhance the efficacy of vaccines. Here, we explore recent advances in TLR biology with a focus on novel drugs that target TLRs (agonists and antagonists) for antiviral therapy.

  2. Managing change : natural gas transportation to the eastern toll zone

    International Nuclear Information System (INIS)

    Valiante, U.

    2001-01-01

    The Cogenerators Alliance includes Ontario's largest end-use natural gas consumers, Tractebel Power, Westcoast Power, Lake Superior Power, TransAlta Energy, Cardinal Power of Canada and Whitby Cogeneration. Together, they represent 157,798 GJ/day contracted volume. This paper focused on the changing face of the natural gas industry in North America with closer economic ties between Canada, the United States and Mexico in a competitive energy market. The role of Alliance Pipeline in transporting natural gas to markets and the implication of regulation and toll increases were also discussed. It was noted that there is a need for regulatory changes to provide existing pipelines with the appropriate tools needed to ensure the competitive environment will function effectively. tabs., figs

  3. Cannabinoids and Innate Immunity: Taking a Toll on Neuroinflammation

    Directory of Open Access Journals (Sweden)

    Eric J. Downer

    2011-01-01

    Full Text Available The biologically active components of cannabis have therapeutic potential in neuroinflammatory disorders due to their anti-inflammatory propensity. Cannabinoids influence immune function in both the peripheral and the central nervous system (CNS, and the components of the cannabinoid system, the cannabinoid receptors and their endogenous ligands (endocannabinoids, have been detected on immune cells as well as in brain glia. Neuroinflammation is the complex innate immune response of neural tissue to control infection and eliminate pathogens, and Toll-like receptors (TLRs, a major family of pattern recognition receptors (PRRs that mediate innate immunity, have emerged as players in the neuroinflammatory processes underpinning various CNS diseases. This review will highlight evidence that cannabinoids interact with the immune system by impacting TLR-mediated signaling events, which may provide cues for devising novel therapeutic approaches for cannabinoid ligands.

  4. Toll-Like Receptors: Role in Dermatological Disease

    Directory of Open Access Journals (Sweden)

    Aswin Hari

    2010-01-01

    Full Text Available Toll-like receptors (TLRs are a class of conserved receptors that recognize pathogen-associated molecular patterns (PAMPs present in microbes. In humans, at least ten TLRs have been identified, and their recognition targets range from bacterial endotoxins to lipopeptides, DNA, dsRNA, ssRNA, fungal products, and several host factors. Of dermatological interest, these receptors are expressed on several skin cells including keratinocytes, melanocytes, and Langerhans cells. TLRs are essential in identifying microbial products and are known to link the innate and adaptive immune systems. Over the years, there have been significant advances in our understanding of TLRs in skin inflammation, cutaneous malignancies, and defence mechanisms. In this paper, we will describe the association between TLRs and various skin pathologies and discuss proposed TLR therapeutics.

  5. Toll-like receptors as therapeutic targets in cystic fibrosis.

    LENUS (Irish Health Repository)

    Greene, Catherine M

    2008-12-01

    Background: Toll-like receptors (TLRs) are pattern recognition receptors that act as a first-line of defence in the innate immune response by recognising and responding to conserved molecular patterns in microbial factors and endogenous danger signals. Cystic fibrosis (CF)-affected airways represent a milieu potentially rich in TLR agonists and the chronic inflammatory phenotype evident in CF airway epithelial cells is probably due in large part to activation of TLRs. Objective\\/methods: To examine the prospects of developing novel therapies for CF by targeting TLRs. We outline the expression and function of TLRs and explore the therapeutic potential of naturally-occurring and synthetic TLR inhibitors for CF. Results\\/conclusion: Modulation of TLRs has therapeutic potential for the inflammatory lung manifestations of CF.

  6. Mapping the Spread of Mounted Warfare

    Directory of Open Access Journals (Sweden)

    Peter Turchin

    2016-12-01

    Full Text Available Military technology is one of the most important factors affecting the evolution of complex societies. In particular, mounted warfare, the use of horse-riders in military operations, revolutionized war as it spread to different parts of Eurasia and Africa during the Ancient and Medieval eras, and to the Americas during the Early Modern period. Here we use a variety of sources to map this spread.

  7. New mounting improves solar-cell efficiency

    Science.gov (United States)

    Shepard, N. F., Jr.

    1980-01-01

    Method boosts output by about 20 percent by trapping and redirecting solar radiation without increasing module depth. Mounted solar-cell array is covered with internally reflecting plate. Plate is attached to each cell by transparent adhesive, and space between cells is covered with layer of diffusely reflecting material. Solar energy falling on space between cells is diffused and reflected internally by plate until it is reflected onto solar cell.

  8. Customer Satisfaction Level in Mount Sherpa Restaurant

    OpenAIRE

    Shrestha, Sameer

    2015-01-01

    Customer satisfaction is the key to every successful business in the sense of profit motive, as well as in the long run. It is the desire of every business to be able to understand their customers’ need. Many businesses, especially related with the service industry, carry out different surveys and conduct research in order to know what their customers really want. This research was carried out to measure the customer satisfaction level in Mount Sherpa restaurant. The results and findings ...

  9. Conceptual design for PSP mounting bracket

    Energy Technology Data Exchange (ETDEWEB)

    Ransom, G.; Stein, R. [Martin Marietta Energy Systems, Inc., Piketon, OH (United States)

    1991-12-31

    Protective structural packages (PSP`s or overpacks) used to ship 2 1/2-ton UF{sub 6} product cylinders are bolted to truck trailers. All bolts penetrate two longitudinal rows of wooden planks. Removal and replacement is required at various intervals for maintenance and routine testing. A conceptual design is presented for mounting brackets which would securely attach PSP`s to trailer frames, reduce removal and replacement time, and minimize risk of personnel injury.

  10. Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Uddman Rolf

    2005-09-01

    Full Text Available Abstract Background Toll-like receptors enable the host to recognize a large number of pathogen-associated molecular patterns such as bacterial lipopolysaccharide, viral RNA, CpG-containing DNA and flagellin. Toll-like receptors have also been shown to play a pivotal role in both innate and adaptive immune responses. The role of Toll-like receptors as a primary part of our microbe defense system has been shown in several studies, but their possible function as mediators in allergy and asthma remains to be established. The present study was designed to examine the expression of Toll-like receptors 2, 3 and 4 in the nasal mucosa of patients with intermittent allergic rhinitis, focusing on changes induced by exposure to pollen. Methods 27 healthy controls and 42 patients with seasonal allergic rhinitis volunteered for the study. Nasal biopsies were obtained before and during pollen season as well as before and after allergen challenge. The seasonal material was used for mRNA quantification of Toll-like receptors 2, 3 and 4 with real-time polymerase chain reaction, whereas specimens achieved in conjunction with allergen challenge were used for immunohistochemical localization and quantification of corresponding proteins. Results mRNA and protein representing Toll-like receptors 2, 3 and 4 could be demonstrated in all specimens. An increase in protein expression for all three receptors could be seen following allergen challenge, whereas a significant increase of mRNA only could be obtained for Toll-like receptor 3 during pollen season. Conclusion The up-regulation of Toll-like receptors 2, 3 and 4 in the nasal mucosa of patients with symptomatic allergic rhinitis supports the idea of a role for Toll-like receptors in allergic airway inflammation.

  11. Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells

    DEFF Research Database (Denmark)

    Chen, R; Alvero, A B; Silasi, D-A

    2008-01-01

    proliferation, would also be key factors in regulating and enhancing cancer progression. The TLR pathways, which play a critical role in tissue repair, are also key regulators in cancer progression as well as chemoresistance. TLRs serve as cell surface sensors that can initiate pathways leading to proliferation......Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore, it would not be surprising that factors that function in the tissue repair process, such as cytokines, chemokines, growth factors and Toll-like receptor (TLR) ligands, as well as growth signals for compensatory...... and chemoresistance; as well as mediators that are able to regulate the infiltrating immune cells to provide further support for cancer progression....

  12. Mounting apparatus for a nozzle guide vane assembly

    Science.gov (United States)

    Boyd, Gary L.; Shaffer, James E.

    1995-01-01

    The present invention provides a ceramic nozzle guide assembly with an apparatus for mounting it to a metal nozzle case that includes an intermediate ceramic mounting ring. The mounting ring includes a plurality of projections that are received within a plurality of receptacles formed in the nozzle case. The projections of the mounting ring are secured within the receptacles by a ceramic retainer that allows contact between the two components only along arcuate surfaces thus eliminating sliding contact between the components.

  13. 46 CFR 61.05-15 - Boiler mountings and attachments.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Boiler mountings and attachments. 61.05-15 Section 61.05... TESTS AND INSPECTIONS Tests and Inspections of Boilers § 61.05-15 Boiler mountings and attachments. (a....05-10. (b) Each stud or bolt for each boiler mounting that paragraph (c) of this section requires to...

  14. Organization and processes of the BN-600 reactor mounting

    International Nuclear Information System (INIS)

    Dubrovin, E.Z.; Karpenko, V.N.; Takhtaulov, V.M.

    1982-01-01

    Structural peculiarities of the BN-600 reactor plant are considered. Experience of metal structure mounting inside the reactor vessel has been analysed. Recommendations on the improvements on the organization of the thermal mechanical equipment mounting are given. It is concluded that the consideration of these recommendations will permit to reduce expenditures of labour by 10-40% for the mounting

  15. [The controversy of routine articulator mounting in orthodontics].

    Science.gov (United States)

    Wang, Li; Han, Xianglong; Bai, Ding

    2013-06-01

    Articulators have been widely used by clinicians of dentistry. But routine articulator mounting is still controversial in orthodontics. Orthodontists oriented by gnathology approve routine articulator mounting while nongnathologic orthodontists disapprove it. This article reviews the thoughts of orthodontist that they agree or disagree with routine articulator mounting based on the considerations of biting, temporomandibular disorder (TMD), periodontitis, and so on.

  16. 49 CFR 571.212 - Standard No. 212; Windshield mounting.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Standard No. 212; Windshield mounting. 571.212... Motor Vehicle Safety Standards § 571.212 Standard No. 212; Windshield mounting. S1. Scope. This standard..., under the conditions of S6, the windshield mounting of the vehicle shall retain not less than the...

  17. Combat vehicle crew helmet-mounted display: next generation high-resolution head-mounted display

    Science.gov (United States)

    Nelson, Scott A.

    1994-06-01

    The Combat Vehicle Crew Head-Mounted Display (CVC HMD) program is an ARPA-funded, US Army Natick Research, Development, and Engineering Center monitored effort to develop a high resolution, flat panel HMD for the M1 A2 Abrams main battle tank. CVC HMD is part of the ARPA High Definition Systems (HDS) thrust to develop and integrate small (24 micrometers square pels), high resolution (1280 X 1024 X 6-bit grey scale at 60 frame/sec) active matrix electroluminescent (AMEL) and active matrix liquid crystal displays (AMLCD) for head mounted and projection applications. The Honeywell designed CVC HMD is a next generation head-mounted display system that includes advanced flat panel image sources, advanced digital display driver electronics, high speed (> 1 Gbps) digital interconnect electronics, and light weight, high performance optical and mechanical designs. The resulting dramatic improvements in size, weight, power, and cost have already led to program spin offs for both military and commercial applications.

  18. ATST telescope mount: telescope of machine tool

    Science.gov (United States)

    Jeffers, Paul; Stolz, Günter; Bonomi, Giovanni; Dreyer, Oliver; Kärcher, Hans

    2012-09-01

    The Advanced Technology Solar Telescope (ATST) will be the largest solar telescope in the world, and will be able to provide the sharpest views ever taken of the solar surface. The telescope has a 4m aperture primary mirror, however due to the off axis nature of the optical layout, the telescope mount has proportions similar to an 8 meter class telescope. The technology normally used in this class of telescope is well understood in the telescope community and has been successfully implemented in numerous projects. The world of large machine tools has developed in a separate realm with similar levels of performance requirement but different boundary conditions. In addition the competitive nature of private industry has encouraged development and usage of more cost effective solutions both in initial capital cost and thru-life operating cost. Telescope mounts move relatively slowly with requirements for high stability under external environmental influences such as wind buffeting. Large machine tools operate under high speed requirements coupled with high application of force through the machine but with little or no external environmental influences. The benefits of these parallel development paths and the ATST system requirements are being combined in the ATST Telescope Mount Assembly (TMA). The process of balancing the system requirements with new technologies is based on the experience of the ATST project team, Ingersoll Machine Tools who are the main contractor for the TMA and MT Mechatronics who are their design subcontractors. This paper highlights a number of these proven technologies from the commercially driven machine tool world that are being introduced to the TMA design. Also the challenges of integrating and ensuring that the differences in application requirements are accounted for in the design are discussed.

  19. Ligands, cell-based models, and readouts required for Toll-like receptor action.

    LENUS (Irish Health Repository)

    Dellacasagrande, Jerome

    2012-02-01

    This chapter details the tools that are available to study Toll-like receptor (TLR) biology in vitro. This includes ligands, host cells, and readouts. The use of modified TLRs to circumvent some technical problems is also discussed.

  20. Role of toll like receptors in bacterial and viral diseases – A ...

    African Journals Online (AJOL)

    Avishek Das

    2017-05-20

    May 20, 2017 ... Cellular Immunology Laboratory, Department of Zoology, University of North ... Background: Toll like receptors are key-receptors of the innate immune ...... Triggering TLR7 in mice induces immune activation and lymphoid.

  1. Modeling Single Occupant Vehicle Behavior in High-Occupancy Toll (HOT) Facilities

    Science.gov (United States)

    2009-12-14

    High-occupancy toll (HOT) lanes are in operation, under construction, and planned for in several major metropolitan areas. The premise behind HOT lanes is to allow single occupant vehicles (SOVs) to access high occupancy vehicle (HOV) lanes (and theo...

  2. Investigation of the feasibility of toll and transit agency equity sharing : white paper.

    Science.gov (United States)

    2010-04-12

    This research project frames the institutional constraints and opportunities for equity sharing that currently exist in the highway, transit and toll agency realms and identifies statutory, regulatory and/or policy changes that may be requried. It al...

  3. Operation Iraqi Freedom/Operation Enduring Freedom: exploring wartime death and bereavement.

    Science.gov (United States)

    Harrington Lamorie, Jill

    2011-01-01

    Military deaths are often sudden, unanticipated, traumatic, and/or violent in nature and involve the death of a young adult. More than 5,500 service members have died as a result of their service in the wars in Afghanistan (2001) and Iraq (2003) in combat- or non-combat- related incidences. As the death toll continues to rise, service members and their families struggle with the visible and invisible wounds of war. This article explores wartime death, trauma, and bereavement experienced by those survivors affected by service members who have died as a result of their military service in Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF). It recognizes the circumstantial and cultural factors of the death as well as the grief and trauma experiences of survivors. Resources and suggested interventions of support are highlighted.

  4. A trolley mounted magazine for reactor maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Brennan, P.J.; Madani, M.; Ridgway, G.H. [GE Hitachi Nuclear Energy Canada, Peterborough, Ontario (Canada)], E-mail: patrick1.brennan@ge.com, mehdi.madani@ge.com, guy.ridgway@ge.com; Lundy, E.; Knight, D. [IM and CS (Inspection, Maintenance and Commerical Services), Ontario Power Generation, Ajax, Ontario (Canada)], E-mail: erroll.lundy@opg.com, david.knight@opg.com

    2009-03-15

    This paper describes the design of a mechanism incorporating a rotary magazine to be mounted on a fuelling machine transport trolley for use at a Darlington reactor during a feeder replacement or maintenance outage. The magazine stores reactor channel maintenance components, such as channel isolation plugs and vented closure plugs, in twelve available magazine channels. Use of the magazine rather than a fuelling machine reduces the time required to transfer such components between the Central Service Area and reactor channels. Component transfers are accomplished by locking the fuelling machine onto one of the magazine channels and using a local controller to execute commands received from the fuel handling control system. (author)

  5. A trolley mounted magazine for reactor maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Brennan, P.J.; Madani, M.; Ridgway, G.H., E-mail: patrick1.brennan@ge.com, E-mail: mehdi.madani@ge.com, E-mail: guy.ridgway@ge.com [GE Hitachi Nuclear Energy Canada, Peterborough, Ontario (Canada); Lundy, E.; Knight, D., E-mail: erroll.lundy@opg.com, E-mail: david.knight@opg.com [Ontario Power Generation, Inspection, Maintenance and Commercial Services, Ajax, Ontario (Canada)

    2008-07-01

    This paper describes the design of a mechanism incorporating a rotary magazine to be mounted on a fuelling machine transport trolley for use at a Darlington reactor during a feeder replacement or maintenance outage. The magazine stores reactor channel maintenance components, such as channel isolation plugs and vented closure plugs, in twelve available magazine channels. Use of the magazine rather than a fuelling machine reduces the time required to transfer such components between the Central Service Area and reactor channels. Component transfers are accomplished by locking the fuelling machine onto one of the magazine channels and using a local controller to execute commands received from the fuel handling control system. (author)

  6. A trolley mounted magazine for reactor maintenance

    International Nuclear Information System (INIS)

    Brennan, P.J.; Madani, M.; Ridgway, G.H.; Lundy, E.; Knight, D.

    2009-01-01

    This paper describes the design of a mechanism incorporating a rotary magazine to be mounted on a fuelling machine transport trolley for use at a Darlington reactor during a feeder replacement or maintenance outage. The magazine stores reactor channel maintenance components, such as channel isolation plugs and vented closure plugs, in twelve available magazine channels. Use of the magazine rather than a fuelling machine reduces the time required to transfer such components between the Central Service Area and reactor channels. Component transfers are accomplished by locking the fuelling machine onto one of the magazine channels and using a local controller to execute commands received from the fuel handling control system. (author)

  7. Mount Zirkel Wilderness and vicinity, Colorado

    International Nuclear Information System (INIS)

    Snyder, G.L.; Patten, L.L.

    1984-01-01

    Several areas of metallic and nonmetallic mineralization have been identified from surface occurrences within the Mount Zirkel Wilderness and vicinity, Colorado. Three areas of probable copper-lead-zinc-silver-gold resource potential, two areas of probable chrome-platinum resource potential, four areas of probable uranium-thorium resource potential, two areas of probable molybdenum resource potential, and one area of probable fluorspar potential were identified by studies in 1965-1973 by the USGS and USBM. No potential for fossil fuel or geothermal resources was identified

  8. A trolley mounted magazine for reactor maintenance

    International Nuclear Information System (INIS)

    Brennan, P.J.; Madani, M.; Ridgway, G.H.; Lundy, E.; Knight, D.

    2008-01-01

    This paper describes the design of a mechanism incorporating a rotary magazine to be mounted on a fuelling machine transport trolley for use at a Darlington reactor during a feeder replacement or maintenance outage. The magazine stores reactor channel maintenance components, such as channel isolation plugs and vented closure plugs, in twelve available magazine channels. Use of the magazine rather than a fuelling machine reduces the time required to transfer such components between the Central Service Area and reactor channels. Component transfers are accomplished by locking the fuelling machine onto one of the magazine channels and using a local controller to execute commands received from the fuel handling control system. (author)

  9. Bovine lactoferrin counteracts Toll-like receptor mediated activation signals in antigen presenting cells.

    Directory of Open Access Journals (Sweden)

    Patrizia Puddu

    Full Text Available Lactoferrin (LF, a key element in mammalian immune system, plays pivotal roles in host defence against infection and excessive inflammation. Its protective effects range from direct antimicrobial activities against a large panel of microbes, including bacteria, viruses, fungi and parasites, to antinflammatory and anticancer activities. In this study, we show that monocyte-derived dendritic cells (MD-DCs generated in the presence of bovine LF (bLF fail to undergo activation by up-modulating CD83, co-stimulatory and major histocompatibility complex molecules, and cytokine/chemokine secretion. Moreover, these cells are weak activators of T cell proliferation and retain antigen uptake activity. Consistent with an impaired maturation, bLF-MD-DC primed T lymphocytes exhibit a functional unresponsiveness characterized by reduced expression of CD154 and impaired expression of IFN-γ and IL-2. The observed imunosuppressive effects correlate with an increased expression of molecules with negative regulatory functions (i.e. immunoglobulin-like transcript 3 and programmed death ligand 1, indoleamine 2,3-dioxygenase, and suppressor of cytokine signaling-3. Interestingly, bLF-MD-DCs produce IL-6 and exhibit constitutive signal transducer and activator of transcription 3 activation. Conversely, bLF exposure of already differentiated MD-DCs completely fails to induce IL-6, and partially inhibits Toll-like receptor (TLR agonist-induced activation. Cell-specific differences in bLF internalization likely account for the distinct response elicited by bLF in monocytes versus immature DCs, providing a mechanistic base for its multiple effects. These results indicate that bLF exerts a potent anti-inflammatory activity by skewing monocyte differentiation into DCs with impaired capacity to undergo activation and to promote Th1 responses. Overall, these bLF-mediated effects may represent a strategy to block excessive DC activation upon TLR-induced inflammation, adding

  10. Colorectal irradiation induced immune response: 'toll like receptors' therapeutic manipulation

    International Nuclear Information System (INIS)

    Lacave-Lapalun, Jean-Victor

    2013-01-01

    Exposure of the abdomino-pelvic sphere to ionizing radiation is associated with a high incidence of complications. Radiation therapy may cause short and / or long-term harmful effects. In the most severe cases and in the absence of heavy treatments, the appearance of ulcers may induce the death of patients. Clinical trials are being conducted with Mesenchymal Stem Cells (MSC) to cure theses complications. Others studies indicate that the injection of bacterial motifs limits the radiotoxicity in the intestine. They stimulate receptors (Toll-Like- Receptors (TLR)) located on the surface of epithelial and intestinal immune cells. The first aim of this doctoral work is to characterize the effects of TLR stimulation on immunity and tissue repair using a model of localized colorectal irradiation at 20 Gy (acute effects of radiotherapy) on a rat. The thesis then aims to potentiate the effects of the MSC treatment when adding TLR ligands upon localized colorectal irradiation at 27 Gy (accidental complications). This work, using a 20 Gy exposure, show that TLR stimulation improves homeostasis (normalization of T cells, induction of regulatory T cells (Treg) and macrophages 'anti-inflammatory' M2). On the 27 Gy colorectal model, the injection of TLR ligand before CSM transplant improves the immune climate by reducing pro-inflammatory cytokines and inducting Treg and M2 cells. These modulations could contribute to improving the implantation and effectiveness of CSM. The observations have all shown that the stimulation of immunity is an approach to minimize radiation-induced lesions. (author) [fr

  11. Classification of busses and lorries in an automatic road toll system

    OpenAIRE

    Jarl, Adam

    2003-01-01

    An automatic road toll system enables the passing vehicles to change lanes and no stop is needed for payment. Because of different weight of personal cars, busses, lorries (trucks) and other vehicles, they affect the road in different ways. It is of interest to categorize the vehicles into different classes depending of their weight so that the right fee can be set. An automatic road toll system developed by Combitech Traffic Systems AB (now Kapsch TrafficCom AB), Joenkoping, Sweden, classifi...

  12. The relationship between emotional labor status and workplace violence among toll collectors

    OpenAIRE

    Joo, Yosub; Rhie, Jeongbae

    2017-01-01

    Background This study aimed to identify the emotional labor and workplace violence status among toll collectors by assessing and comparing the same with that in workers in other service occupation. It also aimed to analyze the relationship between emotional labor and workplace violence. Methods This study examined emotional labor and workplace violence status in 264 female toll collectors from August 20 to September 4, 2015. The emotional labor was assessed using the Korean Emotional Labor Sc...

  13. Roles of Toll-like receptors in allogeneic islet transplantation.

    Science.gov (United States)

    Ro, Han; Hong, Juho; Kim, Beom Seok; Lee, Eun Won; Kim, Myung-Gyu; Han, Kyu Hyun; Yeom, Hye-Jung; Lee, Eun Mi; Jeong, Jong Cheol; Oh, Kook-Hwan; Ahn, Curie; Yang, Jaeseok

    2012-11-27

    Toll-like receptors (TLRs) are involved in the rejection of solid organ allografts. However, the roles of TLRs in islets are still controversial. We investigated the roles of TLRs in donor islets together with those in recipients in allogeneic islet transplantation. To assess the roles of TLRs in either donor islets or recipients, allogeneic islet transplantation was performed using myeloid differentiation factor 88 (MyD88)-knockout (KO), TLR4-KO, or Toll/interleukin-1 receptor domain-containing adaptor-inducing interferon-β (TRIF)-KO mice. Both polyriboinosinic polyribocytidylic acid and lipopolysaccharide (LPS) stimulation induced the mRNA expression of regulated and normal T cell expressed and secreted, interferon-γ-inducible protein-10, monocyte chemotactic protein-1, interleukin-8, and inducible nitric oxide synthase in murine islets, whereas the induction was attenuated in TRIF-KO, interferon-β promoter stimulator-1-KO, and TLR4-KO mice. When islets from MyD88-KO, TLR4-KO, or TRIF-KO C57BL/6 mice were transplanted to BALB/c recipients, graft survival was not better than that of wild-type (WT) islets. However, the survival of the MyD88-KO islet allograft was significantly prolonged when combined with anti-CD40L. In parallel, LPS stimulation in donor islets interfered with anti-CD40L blockade-mediated long-term survival of islet allografts in TLR4-KO recipients. LPS stimulation increased the perigraft infiltration of both T cells and macrophages. Then again, when islets from WT BALB/c mice were transplanted to MyD88-KO, TRIF-KO, or WT C57BL/6 mice, there was no difference in graft survival, although some of the MyD88-KO recipients obtained long-term graft survival. However, anti-CD40L prolonged graft survival significantly in MyD88-KO recipients. The absence of MyD88 in either donors or recipients decreased the perigraft infiltration of inflammatory cells when combined with anti-CD40L. TLRs in both donor islets and recipients are involved in islet allograft

  14. Research on LQR optimal control method of active engine mount

    Science.gov (United States)

    Huan, Xie; Yu, Duan

    2018-04-01

    In this paper, the LQR control method is applied to the active mount of the engine, and a six-cylinder engine excitation model is established. Through the joint simulation of AMESim and MATLAB, the vibration isolation performance of the active mount system and the passive mount system is analyzed. Excited by the multi-engine operation, the simulation results of the vertical displacement, acceleration and dynamic deflection of the vehicle body show that the vibration isolation capability of the active mount system is superior to that of the passive mount system. It shows that compared with the passive mount, LQR active mount can greatly improve the vibration isolation performance, which proves the feasibility and effectiveness of the LQR control method.

  15. A Cost Effective Security Technology Integrated with RFID Based Automated Toll Collection System

    Directory of Open Access Journals (Sweden)

    Rafiya Hossain

    2017-09-01

    Full Text Available Crime statistics and research on criminology show that under similar circumstances,crimes are more likely to occur in developing countries than in developed countries due to their lack ofsecurity measures. Transport crimes on highways and bridges are one of the most common crimes in the developing nations. Automation of various systems like the toll collection system is being introduced in the developing countries to avoid corruption in the collection of toll, decrease cost and increase operational efficiency. The goal of this research is to find an integrated solution that enhances security along with the advantage of automated toll collection. Inspired by the availability of many security systems, this research presents a system that can block a specific vehicle or a particular type of vehicles at the toll booths based on directives from the law enforcement agencies. The heart of the system is based on RFID (Radio Frequency Identification technology. In this system, by sending a text message the law enforcement agency or the authority that controls the toll booths can prevent the barrier from being liftedeven after deduction of the toll charge if the passing vehicle has a security issue. The designed system should help the effort of reducing transport crimes on highways and bridges of developing countries.

  16. Alcohol resistance in Drosophila is modulated by the Toll innate immune pathway.

    Science.gov (United States)

    Troutwine, B R; Ghezzi, A; Pietrzykowski, A Z; Atkinson, N S

    2016-04-01

    A growing body of evidence has shown that alcohol alters the activity of the innate immune system and that changes in innate immune system activity can influence alcohol-related behaviors. Here, we show that the Toll innate immune signaling pathway modulates the level of alcohol resistance in Drosophila. In humans, a low level of response to alcohol is correlated with increased risk of developing an alcohol use disorder. The Toll signaling pathway was originally discovered in, and has been extensively studied in Drosophila. The Toll pathway is a major regulator of innate immunity in Drosophila, and mammalian Toll-like receptor signaling has been implicated in alcohol responses. Here, we use Drosophila-specific genetic tools to test eight genes in the Toll signaling pathway for effects on the level of response to ethanol. We show that increasing the activity of the pathway increases ethanol resistance whereas decreasing the pathway activity reduces ethanol resistance. Furthermore, we show that gene products known to be outputs of innate immune signaling are rapidly induced following ethanol exposure. The interaction between the Toll signaling pathway and ethanol is rooted in the natural history of Drosophila melanogaster. © 2016 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.

  17. National Death Index

    Data.gov (United States)

    U.S. Department of Health & Human Services — The National Death Index (NDI) is a centralized database of death record information on file in state vital statistics offices. Working with these state offices, the...

  18. God's dominion over death.

    Science.gov (United States)

    Schulling, Sharon

    2012-01-01

    This article briefly overviews the criteria for and physiological process of death, contrasting physical death with biblical passages revealing how God interceded in this universal process when Jesus was on earth.

  19. Evaluation of shear mounted elastomeric damper

    Science.gov (United States)

    Zorzi, E.; Walton, J.

    1982-01-01

    Viton-70 elastomeric shear mounted damper was built and tested on a T-55 power turbine spool in the rotor's high speed balancing rig. This application of a shear mounted elastomeric damper demonstrated for the first time, the feasibility of using elastomers as the primary rotor damping source in production turbine engine hardware. The shear damper design was selected because it was compatible with actual gas turbine engine radial space constraints, could accommodate both the radial and axial thrust loads present in gas turbine engines, and was capable of controlled axial preload. The shear damper was interchangeable with the production T-55 power turbine roller bearing support so that a direct comparison between the shear damper and the production support structure could be made. Test results show that the Viton-70 elastomer damper operated successfully and provided excellent control of both synchronous and nonsynchronous vibrations through all phases of testing up to the maximum rotor speed of 16,000 rpm. Excellent correlation between the predicted and experienced critical speeds, mode shapes and log decrements for the power turbine rotor and elastomer damper assembly was also achieved.

  20. Experience with HEP analysis on mounted filesystems

    International Nuclear Information System (INIS)

    Fuhrmann, Patrick; Gasthuber, Martin; Kemp, Yves; Ozerov, Dmitry

    2012-01-01

    We present results on different approaches on mounted filesystems in use or under investigation at DESY. dCache, established since long as a storage system for physics data has implemented the NFS v4.1/pNFS protocol. New performance results will be shown with the most current version of the dCache server. In addition to the native usage of the mounted filesystem in a LAN environment, the results are given for the performance of the dCache NFS v4.1/pNFS in WAN case. Several commercial vendors are currently in alpha or beta phase of adding the NFS v4.1/pNFS protocol to their storage appliances. We will test some of these vendor solutions for their readiness for HEP analysis. DESY has recently purchased an IBM Sonas system. We will present the result of a thorough performance evaluation using the native protocols NFS (v3 or v4) and GPFS. As the emphasis is on the usability for end user analysis, we will use latest ROOT versions and current end user analysis code for benchmark scenarios.

  1. Identity after Death

    DEFF Research Database (Denmark)

    Gerstrøm, Anna

    2015-01-01

    Purpose: The purpose of this paper is to explore how legacy organizational identity and death relate to each other and, thereby, contribute to closing the gap in knowledge on organizational identity constructions in times of death. Design/methodology/approach: The paper opted for an exploratory....../value: This paper addresses an apparent gap in the literature on identity and death; exploring identity narratives in a bankrupted bank, the paper considers constructions of legacy organizational identities in times of disruptive death....

  2. Sudden death victims

    NARCIS (Netherlands)

    Ceelen, Manon; van der Werf, Christian; Hendrix, Anneke; Naujocks, Tatjana; Woonink, Frits; de Vries, Philip; van der Wal, Allard; Das, Kees

    2015-01-01

    The goal of this study was to ascertain accordance between cause of death established by the forensic physician and autopsy results in young sudden death victims in the Netherlands. Sudden death victims aged 1-45 years examined by forensic physicians operating in the participating regions which also

  3. Death and Grief

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Death and Grief KidsHealth / For Teens / Death and Grief What's in this article? What Is ... the reaction we have in response to a death or loss. Grief can affect our body, mind, ...

  4. Toll-Like Receptor Pathways in Autoimmune Diseases.

    Science.gov (United States)

    Chen, Ji-Qing; Szodoray, Peter; Zeher, Margit

    2016-02-01

    Autoimmune diseases are a family of chronic systemic inflammatory disorders, characterized by the dysregulation of the immune system which finally results in the break of tolerance to self-antigen. Several studies suggest that Toll-like receptors (TLRs) play an essential role in the pathogenesis of autoimmune diseases. TLRs belong to the family of pattern recognition receptors (PRRs) that recognize a wide range of pathogen-associated molecular patterns (PAMPs). TLRs are type I transmembrane proteins and located on various cellular membranes. Two main groups have been classified based on their location; the extracelluar group referred to the ones located on the plasma membrane while the intracellular group all located in endosomal compartments responsible for the recognition of nucleic acids. They are released by the host cells and trigger various intracellular pathways which results in the production of proinflammatory cytokines, chemokines, as well as the expression of co-stimulatory molecules to protect against invading microorganisms. In particular, TLR pathway-associated proteins, such as IRAK, TRAF, and SOCS, are often dysregulated in this group of diseases. TLR-associated gene expression profile analysis together with single nucleotide polymorphism (SNP) assessment could be important to explain the pathomechanism driving autoimmune diseases. In this review, we summarize recent findings on TLR pathway regulation in various autoimmune diseases, including Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), multiple sclerosis (MS), rheumatoid arthritis (RA), systemic sclerosis (SSc), and psoriasis.

  5. Intervention on toll-like receptors in pancreatic cancer.

    Science.gov (United States)

    Vaz, Juan; Andersson, Roland

    2014-05-21

    Pancreatic ductal adenocarcinoma (PDA) is a devastating disease with pronounced morbidity and a high mortality rate. Currently available treatments lack convincing cost-efficiency determinations and are in most cases not associated with relevant success rate. Experimental stimulation of the immune system in murine PDA models has revealed some promising results. Toll-like receptors (TLRs) are pillars of the immune system that have been linked to several forms of malignancy, including lung, breast and colon cancer. In humans, TLRs are expressed in the pancreatic cancer tissue and in several cancer cell lines, whereas they are not expressed in the normal pancreas. In the present review, we explore the current knowledge concerning the role of different TLRs associated to PDA. Even if almost all known TLRs are expressed in the pancreatic cancer microenvironment, there are only five TLRs suggested as possible therapeutic targets. Most data points at TLR2 and TLR9 as effective tumor markers and agonists could potentially be used as e.g. future adjuvant therapies. The elucidation of the role of TLR3 in PDA is only in its initial phase. The inhibition/blockage of TLR4-related pathways has shown some promising effects, but there are still many steps left before TLR4 inhibitors can be considered as possible therapeutic agents. Finally, TLR7 antagonists seem to be potential candidates for therapy. Independent of their potential in immunotherapies, all existing data indicate that TLRs are strongly involved in the pathophysiology and development of PDA.

  6. Toll-like receptors and their role in animal reproduction.

    Science.gov (United States)

    Kannaki, T R; Shanmugam, M; Verma, P C

    2011-05-01

    Toll-like receptors (TLRs) are evolutionarily conserved innate immune receptors that recognize pathogen specific molecular pattern (PAMPs) in an efficient, non-self-reactive manner and initiate specific immune signaling that culminates in triggering antigen-specific adaptive responses. Different TLR genes in domestic animal species have been characterized and accumulating evidence from recent studies indicates an extended role for TLR signaling in reproductive physiology. In females, TLRs have been implicated in the regulation of ovulation, fertilization, gestation and parturition, as well as in pathological conditions such as endometritis and mastitis. In males, TLRs play a role in steroidogenesis and spermatogenesis. Use of TLR agonists has also been shown to be effective in the treatment of certain reproductive tract infections. Moreover, gene polymorphisms in TLRs have been associated with mastitis providing evidence that TLRs can potentially be exploited as markers in future breeding programs. The aim of this review is to provide a comprehensive treatise on role of TLRs in male and female reproductive physiology and associated pathology in domestic livestock. Copyright © 2011. Published by Elsevier B.V.

  7. Toll-like receptors as targets for allergen immunotherapy.

    Science.gov (United States)

    Aryan, Zahra; Rezaei, Nima

    2015-12-01

    Toll-like receptors (TLRs) are novel and promising targets for allergen immunotherapy. Bench studies suggest that TLR agonists reduce Th2 responses and ameliorate airway hyper-responsiveness. In addition, clinical trials are at initial phases to evaluate the safety and efficacy of TLR agonists for the allergen immunotherapy of patients with allergic rhinitis and asthma. (Figure is included in full-text article.) To date, two allergy vaccine-containing TLR agonists have been investigated in clinical trials; Pollinex Quattro and AIC. The former contains monophosphoryl lipid, a TLR4 agonist and the latter contains, CpG motifs activating the TLR9 cascade. Preseasonal subcutaneous injection of both of these allergy vaccines has been safe and efficacious in control of nasal symptoms of patients with allergic rhinitis. CRX-675 (a TLR4 agonist), AZD8848 (a TLR7 agonist), VTX-1463 (a TLR8 agonist) and 1018 ISS and QbG10 (TLR9 agonists) are currently in clinical development for allergic rhinitis and asthma. TLR agonists herald promising results for allergen immunotherapy of patients with allergic rhinitis and asthma. Future research should be directed at utilizing these agents for immunotherapy of food allergy (for instance, peanut allergy) as well.

  8. Toll-Like Receptors, Inflammation, and Calcific Aortic Valve Disease

    Directory of Open Access Journals (Sweden)

    Carmen García-Rodríguez

    2018-03-01

    Full Text Available Inflammation, the primary response of innate immunity, is essential to initiate the calcification process underlying calcific aortic valve disease (CAVD, the most prevalent valvulopathy in Western countries. The pathogenesis of CAVD is multifactorial and includes inflammation, hemodynamic factors, fibrosis, and active calcification. In the development of CAVD, both innate and adaptive immune responses are activated, and accumulating evidences show the central role of inflammation in the initiation and propagation phases of the disease, being the function of Toll-like receptors (TLR particularly relevant. These receptors act as sentinels of the innate immune system by recognizing pattern molecules from both pathogens and host-derived molecules released after tissue damage. TLR mediate inflammation via NF-κB routes within and beyond the immune system, and play a crucial role in the control of infection and the maintenance of tissue homeostasis. This review outlines the current notions about the association between TLR signaling and the ensuing development of inflammation and fibrocalcific remodeling in the pathogenesis of CAVD. Recent data provide new insights into the inflammatory and osteogenic responses underlying the disease and further support the hypothesis that inflammation plays a mechanistic role in the initiation and progression of CAVD. These findings make TLR signaling a potential target for therapeutic intervention in CAVD.

  9. Cathepsins are required for Toll-like receptor 9 responses

    International Nuclear Information System (INIS)

    Matsumoto, Fumi; Saitoh, Shin-ichiroh; Fukui, Ryutaroh; Kobayashi, Toshihiko; Tanimura, Natsuko; Konno, Kazunori; Kusumoto, Yutaka; Akashi-Takamura, Sachiko; Miyake, Kensuke

    2008-01-01

    Toll-like receptors (TLR) recognize a variety of microbial products and activate defense responses. Pathogen sensing by TLR2/4 requires accessory molecules, whereas little is known about a molecule required for DNA recognition by TLR9. After endocytosis of microbes, microbial DNA is exposed and recognized by TLR9 in lysosomes. We here show that cathepsins, lysosomal cysteine proteases, are required for TLR9 responses. A cell line Ba/F3 was found to be defective in TLR9 responses despite enforced TLR9 expression. Functional cloning with Ba/F3 identified cathepsin B/L as a molecule required for TLR9 responses. The protease activity was essential for the complementing effect. TLR9 responses were also conferred by cathepsin S or F, but not by cathepsin H. TLR9-dependent B cell proliferation and CD86 upregulation were apparently downregulated by cathepsin B/L inhibitors. Cathepsin B inhibitor downregulated interaction of CpG-B with TLR9 in 293T cells. These results suggest roles for cathepsins in DNA recognition by TLR9

  10. The Role of Toll Like Receptors in Pregnancy

    Directory of Open Access Journals (Sweden)

    Elham Amirchaghmaghi

    2013-09-01

    Full Text Available For many years, the innate immunity was of less interest than the adaptive immunity because it was perceived to have secondary importance in the functionality of the immune system. During the past decades, with the advancement of knowledge about innate immune system, interest in innate immunity has grown dramatically and thus its function has been extensively studied. Innate immunity plays fundamental roles in the initiation and induction of adaptive immune responses. It consists of several cells and receptors including natural killer (NK cells, macrophages (MQs, dendritic cells (DCs and pattern recognition receptors (PRRs. Two decades ago, Toll like receptors (TLRs family was known as one of the important PRRs with unique functions especially in protection against invading pathogens. Since the female reproductive tract has access to the outside environment and has a unique interaction with different pathogens whether invading microorganisms or normal flora, allogenic sperm and semi allogenic fetus, it has an essential need for effective immune responses. It has therefore been suggested that TLRs may play important roles in the immune regulation of the female reproductive tract. In addition, it has been demonstrated that immune disturbance may be responsible for some adverse pregnancy outcomes such as preeclampsia (PE, recurrent spontaneous abortion (RSA and intrauterine growth restriction (IUGR. Our focus in this review is to show the importance of TLRs in pregnancy with emphasis on the expression of these receptors in different tissues related to pregnancy.

  11. Simulation of tunneling construction methods of the Cisumdawu toll road

    Science.gov (United States)

    Abduh, Muhamad; Sukardi, Sapto Nugroho; Ola, Muhammad Rusdian La; Ariesty, Anita; Wirahadikusumah, Reini D.

    2017-11-01

    Simulation can be used as a tool for planning and analysis of a construction method. Using simulation technique, a contractor could design optimally resources associated with a construction method and compare to other methods based on several criteria, such as productivity, waste, and cost. This paper discusses the use of simulation using Norwegian Method of Tunneling (NMT) for a 472-meter tunneling work in the Cisumdawu Toll Road project. Primary and secondary data were collected to provide useful information for simulation as well as problems that may be faced by the contractor. The method was modelled using the CYCLONE and then simulated using the WebCYCLONE. The simulation could show the duration of the project from the duration model of each work tasks which based on literature review, machine productivity, and several assumptions. The results of simulation could also show the total cost of the project that was modeled based on journal construction & building unit cost and online websites of local and international suppliers. The analysis of the advantages and disadvantages of the method was conducted based on its, wastes, and cost. The simulation concluded the total cost of this operation is about Rp. 900,437,004,599 and the total duration of the tunneling operation is 653 days. The results of the simulation will be used for a recommendation to the contractor before the implementation of the already selected tunneling operation.

  12. Trial Watch: Toll-like receptor agonists for cancer therapy.

    Science.gov (United States)

    Vacchelli, Erika; Eggermont, Alexander; Sautès-Fridman, Catherine; Galon, Jérôme; Zitvogel, Laurence; Kroemer, Guido; Galluzzi, Lorenzo

    2013-08-01

    Toll-like receptors (TLRs) have long been known for their ability to initiate innate immune responses upon exposure to conserved microbial components such as lipopolysaccharide (LPS) and double-stranded RNA. More recently, this family of pattern recognition receptors has been attributed a critical role in the elicitation of anticancer immune responses, raising interest in the development of immunochemotherapeutic regimens based on natural or synthetic TLR agonists. In spite of such an intense wave of preclinical and clinical investigation, only three TLR agonists are currently licensed by FDA for use in cancer patients: bacillus Calmette-Guérin (BCG), an attenuated strain of Mycobacterium bovis that operates as a mixed TLR2/TLR4 agonist; monophosphoryl lipid A (MPL), a derivative of Salmonella minnesota that functions as a potent agonist of TLR4; and imiquimod, a synthetic imidazoquinoline that activates TLR7. One year ago, in the August and September issues of OncoImmunology , we described the main biological features of TLRs and discussed the progress of clinical studies evaluating the safety and therapeutic potential of TLR agonists in cancer patients. Here, we summarize the latest developments in this exciting area of research, focusing on preclinical studies that have been published during the last 13 mo and clinical trials launched in the same period to investigate the antineoplastic activity of TLR agonists.

  13. Trial Watch: Toll-like receptor agonists in oncological indications.

    Science.gov (United States)

    Aranda, Fernando; Vacchelli, Erika; Obrist, Florine; Eggermont, Alexander; Galon, Jérôme; Sautès-Fridman, Catherine; Cremer, Isabelle; Henrik Ter Meulen, Jan; Zitvogel, Laurence; Kroemer, Guido; Galluzzi, Lorenzo

    2014-01-01

    Toll-like receptors (TLRs) are an evolutionarily conserved group of enzymatically inactive, single membrane-spanning proteins that recognize a wide panel of exogenous and endogenous danger signals. Besides constituting a crucial component of the innate immune response to bacterial and viral pathogens, TLRs appear to play a major role in anticancer immunosurveillance. In line with this notion, several natural and synthetic TLR ligands have been intensively investigated for their ability to boost tumor-targeting immune responses elicited by a variety of immunotherapeutic and chemotherapeutic interventions. Three of these agents are currently approved by the US Food and Drug Administration (FDA) or equivalent regulatory agencies for use in cancer patients: the so-called bacillus Calmette-Guérin, monophosphoryl lipid A, and imiquimod. However, the number of clinical trials testing the therapeutic potential of both FDA-approved and experimental TLR agonists in cancer patients is stably decreasing, suggesting that drug developers and oncologists are refocusing their interest on alternative immunostimulatory agents. Here, we summarize recent findings on the use of TLR agonists in cancer patients and discuss how the clinical evaluation of FDA-approved and experimental TLR ligands has evolved since the publication of our first Trial Watch dealing with this topic.

  14. The Role of Toll Like Receptors in Hematopoietic Malignancies

    Directory of Open Access Journals (Sweden)

    Darlene Monlish

    2016-09-01

    Full Text Available Toll-like receptors (TLRs are a family of pattern recognition receptors (PRRs that shape the innate immune system by identifying pathogen-associated molecular patterns (PAMPS and host-derived damage associated molecular patterns (DAMPS. TLRs are widely expressed on both immune cells and non-immune cells, including hematopoietic stem and progenitor cells, effector immune cell populations, and endothelial cells. In addition to their well-known role in the innate immune response to acute infection or injury, accumulating evidence supports a role for TLRs in the development of hematopoietic and other malignancies. Several hematopoietic disorders, including lymphoproliferative disorders and myelodysplastic syndromes, which possess a high risk of transformation to leukemia, have been linked to aberrant TLR signaling. Furthermore, activation of TLRs leads to the induction of a number of pro-inflammatory cytokines and chemokines, which can promote tumorigenesis by driving cell proliferation and migration and providing a favorable microenvironment for tumor cells. Beyond hematopoietic malignancies, the upregulation of a number of TLRs has been linked to promoting tumor cell survival, proliferation, and metastasis in a variety of cancers, including those of the colon, breast, and lung. This review focuses on the contribution of TLRs to hematopoietic malignancies, highlighting the known direct and indirect effects of TLR signaling on tumor cells and their microenvironment. In addition, the utility of TLR agonists and antagonists as potential therapeutics in the treatment of hematopoietic malignancies is discussed.

  15. Tyrosine Phosphorylation in Toll-Like Receptor Signaling

    Science.gov (United States)

    Chattopadhyay, Saurabh; Sen, Ganes C.

    2014-01-01

    There is a wealth of knowledge about how different Ser/Thr protein kinases participate in Toll-like receptor (TLR) signaling. In many cases, we know the identities of the Ser/Thr residues of various components of the TLR-signaling pathways that are phosphorylated, the functional consequences of the phosphorylation and the responsible protein kinases. In contrast, the analysis of Tyr-phosphorylation of TLRs and their signaling proteins is currently incomplete, because several existing analyses are not systematic or they do not rely on robust experimental data. Nevertheless, it is clear that many TLRs require, for signaling, ligand-dependent phosphorylation of specific Tyr residues in their cytoplasmic domains; the list includes TLR2, TLR3, TLR4, TLR5, TLR8 and TLR9. In this article, we discuss the current status of knowledge on the effect of Tyr-phosphorylation of TLRs and their signaling proteins on their biochemical and biological functions, the possible identities of the relevant protein tyrosine kinases (PTKs) and the nature of regulations of PTK-mediated activation of TLR signaling pathways. PMID:25022196

  16. Negative regulation of Toll-like receptor signalling 

    Directory of Open Access Journals (Sweden)

    Halina Antosz

    2013-04-01

    Full Text Available The mechanism of innate immunity is based on the pattern recognition receptors (PRR that recognize molecular patterns associated with pathogens (PAMPs. Among PRR receptors Toll-like receptors (TLR are distinguished. As a result of contact with pathogens, TLRs activate specific intracellular signaling pathways. It happens through proteins such as adaptor molecules, e.g. MyD88, TIRAP, TRIF, TRAM, and IPS-1, which participate in the cascade activation of kinases (IKK, MAP, RIP-1, TBK-1 as well as transcription factors (NF-κB, AP-1 and regulatory factor (IRF3. The result of this activation is the production of active proinflammatory cytokines, chemokines, interferons and enzymes. The PRR pathways are controlled by extra – and intracellular molecules to prevent overexpression of PRR. They include soluble receptors (sTLR, transmembrane proteins (ST2, SIGIRR, RP105, TRAIL-R and intracellular inhibitors (SOCS-1, SOCS-3, sMyD88, TOLLIP, IRAK-M, SARM, A20, β-arrestin, CYLD, SHP. These molecules maintain the balance between activation and inhibition and ensure balancing of the beneficial and adverse effects of antigen recognition.

  17. The TRIPS (Toll-like receptors in immuno-inflammatory pathogenesis) Hypothesis: a novel postulate to understand schizophrenia.

    Science.gov (United States)

    Venkatasubramanian, Ganesan; Debnath, Monojit

    2013-07-01

    Mounting evidence indicates that immune activation and/or immuno-inflammatory reactions during neurodevelopment apparently contribute to the pathogenesis and progression of schizophrenia. One of the important environmental factors that is known to trigger immune activation/inflammatory responses during early pregnancy is prenatal infection. Recent understanding from animal studies suggests that prenatal infection induced maternal immune activation (MIA)/inflammation in congruence with oxidative/nitrosative stress can lead to neurodevelopmental damage and behavioral abnormalities in the offspring. Although the underlying precise mechanistic processes of MIA/inflammation are yet to be completely elucidated, it is being increasingly recognized that Toll-like receptors (TLRs) that form the first line of defense against invading microorganisms could participate in the prenatal infection induced immune insults. Interestingly, some of the TLRs, especially TLR3 and TLR4 that modulate neurodevelopment, neuronal survival and neuronal plasticity by regulating the neuro-immune cross-talk in the developing and adult brain could also be affected by prenatal infection. Importantly, sustained activation of TLR3/TLR4 due to environmental factors including infection and stress has been found to generate excessive reactive oxygen species (ROS)/reactive nitrogen species (RNS) as well as pro-inflammatory mediators during embryogenesis, which result into neuronal damage by necrosis/apoptosis. In recent times, ROS/RNS and immuno-inflammatory mediators are being increasingly linked to progressive brain changes in schizophrenia. Although a significant role of TLR3/TLR4 in neurodegeneration is gaining certainty, their importance in establishing a causal link between prenatal infection and immuno-inflammatory, oxidative and nitrosative stress (IO&NS) responses and influence on adult presentation of schizophrenia is yet to be ascertained. We review here the current knowledge generated from

  18. Improved resolution by mounting of tissue sections for laser microdissection.

    Science.gov (United States)

    van Dijk, M C R F; Rombout, P D M; Dijkman, H B P M; Ruiter, D J; Bernsen, M R

    2003-08-01

    Laser microbeam microdissection has greatly facilitated the procurement of specific cell populations from tissue sections. However, the fact that a coverslip is not used means that the morphology of the tissue sections is often poor. To develop a mounting method that greatly improves the morphological quality of tissue sections for laser microbeam microdissection purposes so that the identification of target cells can be facilitated. Fresh frozen tissue and formalin fixed, paraffin wax embedded tissue specimens were used to test the morphological quality of mounted and unmounted tissue. The mounting solution consisted of an adhesive gum and blue ink diluted in water. Interference of the mounting solution with DNA quality was analysed by the polymerase chain reaction using 10-2000 cells isolated by microdissection from mounted and unmounted tissue. The mounting solution greatly improved the morphology of tissue sections for laser microdissection purposes and had no detrimental effects on the isolation and efficiency of amplification of DNA. One disadvantage was that the mounting solution reduced the cutting efficiency of the ultraviolet laser. To minimise this effect, the mounting solution should be diluted as much as possible. Furthermore, the addition of blue ink to the mounting medium restores the cutting efficiency of the laser. The mounting solution is easy to prepare and apply and can be combined with various staining methods without compromising the quality of the DNA extracted.

  19. Eyelid closure at death

    Directory of Open Access Journals (Sweden)

    A D Macleod

    2009-01-01

    Full Text Available Aim: To observe the incidence of full or partial eyelid closure at death. Materials and Methods: The presence of ptosis was recorded in 100 consecutive hospice patient deaths. Results: Majority (63% of the patients died with their eyes fully closed, however, 37% had bilateral ptosis at death, with incomplete eye closure. In this study, central nervous system tumor involvement and/or acute hepatic encephalopathy appeared to be pre-mortem risk factors of bilateral ptosis at death. Conclusion: Organicity and not psychogenicity is, therefore, the likely etiology of failure of full eyelid closure at death.

  20. Eruptive history of Mount Katmai, Alaska

    Science.gov (United States)

    Hildreth, Edward; Fierstein, Judith

    2012-01-01

    Mount Katmai has long been recognized for its caldera collapse during the great pyroclastic eruption of 1912 (which vented 10 km away at Novarupta in the Valley of Ten Thousand Smokes), but little has previously been reported about the geology of the remote ice-clad stratovolcano itself. Over several seasons, we reconnoitered all parts of the edifice and sampled most of the lava flows exposed on its flanks and caldera rim. The precipitous inner walls of the 1912 caldera remain too unstable for systematic sampling; so we provide instead a photographic and interpretive record of the wall sequences exposed. In contrast to the several andesite-dacite stratovolcanoes nearby, products of Mount Katmai range from basalt to rhyolite. Before collapse in 1912, there were two overlapping cones with separate vent complexes and craters; their products are here divided into eight sequences of lava flows, agglutinates, and phreatomagmatic ejecta. Latest Pleistocene and Holocene eruptive units include rhyodacite and rhyolite lava flows along the south rim; a major 22.8-ka rhyolitic plinian fall and ignimbrite deposit; a dacite-andesite zoned scoria fall; a thick sheet of dacite agglutinate that filled a paleocrater and draped the west side of the edifice; unglaciated leveed dacite lava flows on the southeast slope; and the Horseshoe Island dacite dome that extruded on the caldera floor after collapse. Pre-collapse volume of the glaciated Katmai edifice was ∼30 km3, and eruptive volume is estimated to have been 57±13 km3. The latter figure includes ∼40±6 km3 for the edifice, 5±2 km3 for off-edifice dacite pyroclastic deposits, and 12±5 km3 for the 22.8-ka rhyolitic pyroclastic deposits. To these can be added 13.5 km3 of magma that erupted at Novarupta in 1912, all or much of which is inferred to have been withdrawn from beneath Mount Katmai. The oldest part of the edifice exposed is a basaltic cone, which gave a 40Ar/39Ar plateau age of 89 ± 25 ka.

  1. Rack assembly for mounting solar modules

    Science.gov (United States)

    Plaisted, Joshua Reed; West, Brian

    2010-12-28

    A rack assembly is provided for mounting solar modules over an underlying body. The rack assembly may include a plurality of rail structures that are arrangeable over the underlying body to form an overall perimeter for the rack assembly. One or more retention structures may be provided with the plurality of rail structures, where each retention structure is configured to support one or more solar modules at a given height above the underlying body. At least some of the plurality of rail structures are adapted to enable individual rail structures o be sealed over the underlying body so as to constrain air flow underneath the solar modules. Additionally, at least one of (i) one or more of the rail structures, or (ii) the one or more retention structures are adjustable so as to adapt the rack assembly to accommodate solar modules of varying forms or dimensions.

  2. Article mounting and position adjustment stage

    Science.gov (United States)

    Cutburth, Ronald W.; Silva, Leonard L.

    1988-01-01

    An improved adjustment and mounting stage of the type used for the detection of laser beams is disclosed. A ring sensor holder has locating pins on a first side thereof which are positioned within a linear keyway in a surrounding housing for permitting reciprocal movement of the ring along the keyway. A rotatable ring gear is positioned within the housing on the other side of the ring from the linear keyway and includes an oval keyway which drives the ring along the linear keyway upon rotation of the gear. Motor-driven single-stage and dual (x, y) stage adjustment systems are disclosed which are of compact construction and include a large laser transmission hole.

  3. MOUNT HOOD WILDERNESS AND ADJACENT AREAS, OREGON.

    Science.gov (United States)

    Keith, T.E.C.; Causey, J.D.

    1984-01-01

    A mineral survey of the Mount Hood Wilderness, Oregon, was conducted. Geochemical data indicate two areas of substantiated mineral-resource potential containing weak epithermal mineralization: an area of the north side of Zigzag Mountain where vein-type lead-zinc-silver deposits occur and an area of the south side of Zigzag Mountain, where the upper part of a quartz diorite pluton has propylitic alteration associated with mineralization of copper, gold, silver, lead, and zinc in discontinuous veins. Geothermal-resource potential for low- to intermediate-temperature (less than 248 degree F) hot-water systems in the wilderness is probable in these areas. Part of the wilderness is classified as a Known Geothermal Resource Area (KGRA), which is considered to have probable geothermal-resource potential, and two parts of the wilderness have been included in geothermal lease areas.

  4. Photovoltaic array mounting apparatus, systems, and methods

    Science.gov (United States)

    West, John Raymond; Atchley, Brian; Hudson, Tyrus Hawkes; Johansen, Emil

    2014-12-02

    An apparatus for mounting a photovoltaic (PV) module on a surface, including a support with an upper surface, a lower surface, tabs, one or more openings, and a clip comprising an arm and a notch, where the apparatus resists wind forces and seismic forces and creates a grounding electrical bond between the PV module, support, and clip. The invention further includes a method for installing PV modules on a surface that includes arranging supports in rows along an X axis and in columns along a Y axis on a surface such that in each row the distance between two neighboring supports does not exceed the length of the longest side of a PV module and in each column the distance between two neighboring supports does not exceed the length of the shortest side of a PV module.

  5. Insectivore Plants Nepenthes sp. at Mount Merbabu

    Directory of Open Access Journals (Sweden)

    AHMAD DWI SETYAWAN

    2000-07-01

    Full Text Available The aims of the research were to know the existence of the Nepenthes at mount Merbabu, variations of its morphology, associated plants, and ecological conditions. Nepenthes are one of plants that were categorized as conserved plant by Indonesian government as indicated in PPRI No. 7/1999. Many researchers attracted to study this unique plant since it’s distinct feature and the way to get nutrient by trapping insects at its sac. Samples were taken randomly along the path for climbing from Selo, Boyolali to the top of the mountain between April to May 2000. The results show that the plants were found at the altitude of around 1500 to 2000 tsl. There were two forms of the sacs, long and short at the same individual plants. The plants grow coiling on Myristica trees and shrubs of Thunbergia fragrans Roxb., and also could grow at the stoned-soil.

  6. Robotized Surface Mounting of Permanent Magnets

    Directory of Open Access Journals (Sweden)

    Erik Hultman

    2014-10-01

    Full Text Available Using permanent magnets on a rotor can both simplify the design and increase the efficiency of electric machines compared to using electromagnets. A drawback, however, is the lack of existing automated assembly methods for large machines. This paper presents and motivates a method for robotized surface mounting of permanent magnets on electric machine rotors. The translator of the Uppsala University Wave Energy Converter generator is used as an example of a rotor. The robot cell layout, equipment design and assembly process are presented and validated through computer simulations and experiments with prototype equipment. A comparison with manual assembly indicates substantial cost savings and an improved work environment. By using the flexibility of industrial robots and a scalable equipment design, it is possible for this assembly method to be adjusted for other rotor geometries and sizes. Finally, there is a discussion on the work that remains to be done on improving and integrating the robot cell into a production line.

  7. MOUNT PELE, AN ECOCLIMATIC GRADIENT GENERATOR

    Directory of Open Access Journals (Sweden)

    PHILIPPE JOSEPH

    2013-05-01

    Full Text Available Generally, mountains determine the characteristics of particular areas, because of the island phenomenon they cause. However, the geological origins of mountains are multiple and they are located in different climatic regions. Nevertheless, in all aspects they reflect the basic elements of the local biologic unit. The shapes, climates, diverse water resources, biocenoses and the generated soils are the different components that determine, through their dynamic interaction, the “Mountain” ecosystem. Tectonic subduction processes lead to the development of islands such as Martinique, whose basic structure consists of a series of mountains (among them Mount Pele. Like the topographic divisions, the local micro-climates, water courses, different soils (themselves the consequences of the presence of the mountain itself and successive volcanic eruptions determine, over time, the organization of the diverse vegetal entities.

  8. DMPD: Toll-like receptor 9 in murine lupus: more friend than foe! [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18241699 Toll-like receptor 9 in murine lupus: more friend than foe! Yu P, Musette ...us: more friend than foe! PubmedID 18241699 Title Toll-like receptor 9 in murine lupus...P, Peng SL. Immunobiology. 2008;213(2):151-7. Epub 2007 Sep 21. (.png) (.svg) (.html) (.csml) Show Toll-like receptor 9 in murine lup

  9. Signaling flux redistribution at toll-like receptor pathway junctions.

    Directory of Open Access Journals (Sweden)

    Kumar Selvarajoo

    Full Text Available Various receptors on cell surface recognize specific extracellular molecules and trigger signal transduction altering gene expression in the nucleus. Gain or loss-of-function mutations of one molecule have shown to affect alternative signaling pathways with a poorly understood mechanism. In Toll-like receptor (TLR 4 signaling, which branches into MyD88- and TRAM-dependent pathways upon lipopolysaccharide (LPS stimulation, we investigated the gain or loss-of-function mutations of MyD88. We predict, using a computational model built on the perturbation-response approach and the law of mass conservation, that removal and addition of MyD88 in TLR4 activation, enhances and impairs, respectively, the alternative TRAM-dependent pathway through signaling flux redistribution (SFR at pathway branches. To verify SFR, we treated MyD88-deficient macrophages with LPS and observed enhancement of TRAM-dependent pathway based on increased IRF3 phosphorylation and induction of Cxcl10 and Ifit2. Furthermore, increasing the amount of MyD88 in cultured cells showed decreased TRAM binding to TLR4. Investigating another TLR4 pathway junction, from TRIF to TRAF6, RIP1 and TBK1, the removal of MyD88-dependent TRAF6 increased expression of TRAM-dependent Cxcl10 and Ifit2. Thus, we demonstrate that SFR is a novel mechanism for enhanced activation of alternative pathways when molecules at pathway junctions are removed. Our data suggest that SFR may enlighten hitherto unexplainable intracellular signaling alterations in genetic diseases where gain or loss-of-function mutations are observed.

  10. Toll-like receptor polymorphisms in malaria-endemic populations

    Directory of Open Access Journals (Sweden)

    Zimmerman Peter A

    2009-03-01

    Full Text Available Abstract Background Toll-like receptors (TLR and related downstream signaling pathways of innate immunity have been implicated in the pathogenesis of Plasmodium falciparum malaria. Because of their potential role in malaria pathogenesis, polymorphisms in these genes may be under selective pressure in populations where this infectious disease is endemic. Methods A post-PCR Ligation Detection Reaction-Fluorescent Microsphere Assay (LDR-FMA was developed to determine the frequencies of TLR2, TLR4, TLR9, MyD88-Adaptor Like Protein (MAL single nucleotide polymorphisms (SNPs, and TLR2 length polymorphisms in 170 residents of two regions of Kenya where malaria transmission is stable and high (holoendemic or episodic and low, 346 residents of a malaria holoendemic region of Papua New Guinea, and 261 residents of North America of self-identified ethnicity. Results The difference in historical malaria exposure between the two Kenyan sites has significantly increased the frequency of malaria protective alleles glucose-6-phoshpate dehydrogenase (G6PD and Hemoglobin S (HbS in the holoendemic site compared to the episodic transmission site. However, this study detected no such difference in the TLR2, TLR4, TLR9, and MAL allele frequencies between the two study sites. All polymorphisms were in Hardy Weinberg Equilibrium in the Kenyan and Papua New Guinean populations. TLR9 SNPs and length polymorphisms within the TLR2 5' untranslated region were the only mutant alleles present at a frequency greater than 10% in all populations. Conclusion Similar frequencies of TLR2, TLR4, TLR9, and MAL genetic polymorphisms in populations with different histories of malaria exposure suggest that these innate immune pathways have not been under strong selective pressure by malaria. Genotype frequencies are consistent with Hardy-Weinberg Equilibrium and the Neutral Theory, suggesting that genetic drift has influenced allele frequencies to a greater extent than selective

  11. Toll-like receptor 9 mediated responses in cardiac fibroblasts.

    Directory of Open Access Journals (Sweden)

    Ingrid Kristine Ohm

    Full Text Available Altered cardiac Toll-like receptor 9 (TLR9 signaling is important in several experimental cardiovascular disorders. These studies have predominantly focused on cardiac myocytes or the heart as a whole. Cardiac fibroblasts have recently been attributed increasing significance in mediating inflammatory signaling. However, putative TLR9-signaling through cardiac fibroblasts remains non-investigated. Thus, our aim was to explore TLR9-signaling in cardiac fibroblasts and investigate the consequence of such receptor activity on classical cardiac fibroblast cellular functions. Cultivated murine cardiac fibroblasts were stimulated with different TLR9 agonists (CpG A, B and C and assayed for the secretion of inflammatory cytokines (tumor necrosis factor α [TNFα], CXCL2 and interferon α/β. Expression of functional cardiac fibroblast TLR9 was proven as stimulation with CpG B and -C caused significant CXCL2 and TNFα-release. These responses were TLR9-specific as complete inhibition of receptor-stimulated responses was achieved by co-treatment with a TLR9-antagonist (ODN 2088 or chloroquine diphosphate. TLR9-stimulated responses were also found more potent in cardiac fibroblasts when compared with classical innate immune cells. Stimulation of cardiac fibroblasts TLR9 was also found to attenuate migration and proliferation, but did not influence myofibroblast differentiation in vitro. Finally, results from in vivo TLR9-stimulation with subsequent fractionation of specific cardiac cell-types (cardiac myocytes, CD45+ cells, CD31+ cells and cardiac fibroblast-enriched cell-fractions corroborated our in vitro data and provided evidence of differentiated cell-specific cardiac responses. Thus, we conclude that cardiac fibroblast may constitute a significant TLR9 responder cell within the myocardium and, further, that such receptor activity may impact important cardiac fibroblast cellular functions.

  12. Hall Current Plasma Source Having a Center-Mounted or a Surface-Mounted Cathode

    Science.gov (United States)

    Martinez, Rafael A. (Inventor); Williams, John D. (Inventor); Moritz, Jr., Joel A. (Inventor); Farnell, Casey C. (Inventor)

    2018-01-01

    A miniature Hall current plasma source apparatus having magnetic shielding of the walls from ionized plasma, an integrated discharge channel and gas distributor, an instant-start hollow cathode mounted to the plasma source, and an externally mounted keeper, is described. The apparatus offers advantages over other Hall current plasma sources having similar power levels, including: lower mass, longer lifetime, lower part count including fewer power supplies, and the ability to be continuously adjustable to lower average power levels using pulsed operation and adjustment of the pulse duty cycle. The Hall current plasma source can provide propulsion for small spacecraft that either do not have sufficient power to accommodate a propulsion system or do not have available volume to incorporate the larger propulsion systems currently available. The present low-power Hall current plasma source can be used to provide energetic ions to assist the deposition of thin films in plasma processing applications.

  13. Galvanic coupling effects for module-mounting elements of ground-mounted photovoltaic power station

    Directory of Open Access Journals (Sweden)

    Pierozynski Boguslaw

    2017-12-01

    Full Text Available This communication reports on the concerns associated with possible generation of galvanic coupling effects for construction materials that are used to manufacture mounting assemblies for ground-mounted photovoltaic (PV power stations. For this purpose, six macro-corrosion galvanic cells were assembled, including: hot-dip Zn/Magnelis®-coated steel/Al and stainless steel (SS/Al cells. Corrosion experiments involved continuous, ca. three-month exposure of these couplings in 3 wt.% NaCl solution, conducted at room temperature for a stable pH value of around 8. All corrosion cells were subjected to regular assessment of galvanic current-density and potential parameters, where special consideration was given to compare the corrosion behaviour of Zn-coated steel samples with that of Magnelis®-coated electrodes. Characterization of surface condition and elemental composition for examined materials was carried-out by means of SEM and EDX spectroscopy techniques.

  14. Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent.

    Directory of Open Access Journals (Sweden)

    Carmen M Dickinson-Copeland

    Full Text Available Plasmodium falciparum infection can cause microvascular dysfunction, cerebral encephalopathy and death if untreated. We have previously shown that high concentrations of free heme, and C-X-C motif chemokine 10 (CXCL10 in sera of malaria patients induce apoptosis in microvascular endothelial and neuronal cells contributing to vascular dysfunction, blood-brain barrier (BBB damage and mortality. Endothelial progenitor cells (EPC are microvascular endothelial cell precursors partly responsible for repair and regeneration of damaged BBB endothelium. Studies have shown that EPC's are depleted in severe malaria patients, but the mechanisms mediating this phenomenon are unknown. Toll-like receptors recognize a wide variety of pathogen-associated molecular patterns generated by pathogens such as bacteria and parasites. We tested the hypothesis that EPC depletion during malaria pathogenesis is a function of heme-induced apoptosis mediated by CXCL10 induction and toll-like receptor (TLR activation. Heme and CXCL10 concentrations in plasma obtained from malaria patients were elevated compared with non-malaria subjects. EPC numbers were significantly decreased in malaria patients (P < 0.02 and TLR4 expression was significantly elevated in vivo. These findings were confirmed in EPC precursors in vitro; where it was determined that heme-induced apoptosis and CXCL10 expression was TLR4-mediated. We conclude that increased serum heme mediates depletion of EPC during malaria pathogenesis.

  15. Existential Concerns About Death

    DEFF Research Database (Denmark)

    Moestrup, Lene; Hansen, Helle Ploug

    2015-01-01

    psychology or Kübler-Ross’ theory about death stages. The complex concerns might be explained using Martin Heidegger’s phenomenological thinking. We aimed to illuminate dying patients´ existential concerns about the impending death through a descriptive analysis of semi-structured interviews with 17 cancer...... patients in Danish hospices. The main findings demonstrated how the patients faced the forthcoming death without being anxious of death but sorrowful about leaving life. Furthermore, patients expressed that they avoided thinking about death. However, some had reconstructed specific and positive ideas about...... afterlife and made accurate decisions for practical aspects of their death. The patients wished to focus on positive aspects in their daily life at hospice. It hereby seems important to have ongoing reflections and to include different theoretical perspectives when providing existential support to dying...

  16. The relationship between emotional labor status and workplace violence among toll collectors.

    Science.gov (United States)

    Joo, Yosub; Rhie, Jeongbae

    2017-01-01

    This study aimed to identify the emotional labor and workplace violence status among toll collectors by assessing and comparing the same with that in workers in other service occupation. It also aimed to analyze the relationship between emotional labor and workplace violence. This study examined emotional labor and workplace violence status in 264 female toll collectors from August 20 to September 4, 2015. The emotional labor was assessed using the Korean Emotional Labor Scale (K-ELS), and a questionnaire was used to examine the presence or absence, and type and frequency of workplace violence experienced by the subjects. A linear regression analysis was also performed to analyze the relationship between workplace violence and emotional labor. The scores on "emotional demanding and regulation ( p  workplace violence, whereas they were "normal" of emotional labor in those who did not. Even after being adjusted in the linear regression analysis, the emotional labor scores for the above 4 sub-categories were still significantly high in those who experienced workplace violence. On comparing the present scores with 13 other service occupations, it was found that toll collectors had the highest level in "emotional disharmony and hurt," "organizational surveillance and monitoring," and "organizational supportive and protective system". This study found that the toll collectors engaged in a high level of emotional labor. Additionally, there was a significant relationship between emotional labor and the experience of workplace violence among the toll collectors.

  17. FLOW PATTERNS OF VEHICULAR TRAFFIC ALONG HIGHWAY TOLL PLAZA IN OGUN STATE

    Directory of Open Access Journals (Sweden)

    Bashiru A. Raji

    2009-06-01

    Full Text Available Congestion on our highways, freeways and arterials are increasing at an alarming rate. This occurs because there is an increase in vehicular growth without a corresponding increase in road size, and this has made free flow of traffic a preponderant problem in our highways. Toll plaza causes delay on our highways and results are formation of queue. This paper examined how simple queuing model can be used to determine traffic intensity and the flow pattern of car traffic at a toll plaza. The study was carried out with twelve field assistants at Ogere toll plaza in Ogun State. Findings show a significant variation in the degree of hourly traffic intensities at the four pay points for cars at the toll plaza. However, variation in the daily traffic intensities at the four pay points for cars showed no significant variation. The study also revealed that bumps constructed to check vehicles speed, hawker’s trading activities are among other factors that constitute hindrance to free flow of traffic other than service time and inter-arrival time of cars at the toll plaza. It is therefore recommended that appropriate authority should look into these factors and take necessary steps towards ensuring free flow of traffic at the plaza.

  18. Sudden Infant Death Syndrome (SIDS)

    Science.gov (United States)

    Sudden infant death syndrome (SIDS) Overview Sudden infant death syndrome (SIDS) is the unexplained death, usually during sleep, of a seemingly healthy baby ... year old. SIDS is sometimes known as crib death because the infants often die in their cribs. ...

  19. Flush mounting of thin film sensors

    Science.gov (United States)

    Moore, Thomas C., Sr. (Inventor)

    1992-01-01

    Flush mounting of a sensor on a surface is provided by first forming a recessed area on the surface. Next, an adhesive bonding mixture is introduced into the recessed area. The adhesive bonding mixture is chosen to provide thermal expansion matching with the surface surrounding the recessed area. A strip of high performance polymeric tape is provided, with the sensor attached to the underside thereof, and the tape is positioned over the recessed area so that it acts as a carrier of the sensor. A shim having flexibility so that it will conform to the surface surrounding the recessed area is placed over the tape, and a vacuum pad is placed over the shim. The area above the surface is then evacuated while holding the sensor flush with the surface during curing of the adhesive bonding mixture. After such curing, the pad, shim, and tape are removed from the sensor, electrical connections for the sensor are provided, after which the remaining space in the recessed area is filled with a polymeric foam.

  20. Virtual sine arm kinematic mount system

    International Nuclear Information System (INIS)

    Xu, Z.; Randall, K.J.

    1997-01-01

    A novel kinematic mount system for a vertical focusing mirror of the soft x-ray spectroscopy beamline at the Advanced Photon Source is described. The system contains three points in a horizontal plane. Each point consists of two horizontal linear precision stages, a spherical ball bearing, and a vertical precision stage. The horizontal linear stages are aligned orthogonally and are conjoined by a spherical ball bearing, supported by the vertical linear stage at each point. The position of each confined horizontal stage is controlled by a motorized micrometer head by spring-loading the flat tip of the micrometer head onto a tooling ball fixing on the carriage of the stage. A virtual sine arm is formed by tilting the upstream horizontal stage down and the two downstream horizontal stages up by a small angle. The fine pitch motion is achieved by adjusting the upstream stage. This supporting structure is extremely steady due to a relatively large span across the supporting points and yields extremely high resolution on the pitch motion. With a one degree tilt and a microstepping motor, the authors achieved a 0.4 nanoradian resolution on the mirror pitch motion

  1. Deaths From Secondhand Smoke Exposure in the United States: Economic Implications

    Science.gov (United States)

    Sung, Hai-Yen; Shi, Yanling

    2012-01-01

    Objectives. We estimated the number of deaths attributable to secondhand smoke (SHS), years of potential life lost (YPLL), and value of lost productivity for different US racial/ethnic groups in 2006. Methods. We determined the number of SHS–related deaths among nonsmokers from 2 adult and 4 infant conditions using an epidemiological approach. We estimated adult SHS exposure using detectable serum cotinine. For each death, we determined the YPLL and the value of lost productivity. Results. SHS exposure resulted in more than 42 000 deaths: more than 41 000 adults and nearly 900 infants. Blacks accounted for 13% of all deaths but 24% to 36% of infant deaths. SHS–attributable deaths resulted in a loss of nearly 600 000 YPLL and $6.6 billion of lost productivity, or $158 000 per death. The value of lost productivity per death was highest among Blacks ($238 000) and Hispanics ($193 000). Conclusions. The economic toll of SHS exposure is substantial, with communities of color having the greatest losses. Interventions need to be designed to reduce the health and economic burden of smoking on smokers and nonsmokers alike and on particularly vulnerable groups. PMID:22994180

  2. Measuring the Capacity and Transaction Time of Cash and Electronic Toll Collection Systems

    Directory of Open Access Journals (Sweden)

    Rudy Hermawan Karsaman

    2014-07-01

    Full Text Available A long queue can occur at tollgates due to the amount of transaction time required to perform ticket payment and toll fee collection. This problem can be addressed by the use of an electronic toll collection (ETC system. A case study conducted on the Jakarta Intra Urban, Cikupa-Merak, and Cawang Pluit Toll Roads suggests that the queueing at the tollgates when modelled followed a Poisson distribution. The average cash transaction time was approximately 5 to 6 seconds, while the ETC transaction time was only 4 seconds. Furthermore, the capacity of the cash system gate was 550 to 620 vehicles/hour (which is above the minimum service standard of 450 vehicles/hour,whereas the electronic gate capacity was 770 to 870 vehicles/hour. This study demonstrates that the ETC system is more effective than the cash system in terms of reducing the number of queueing vehicles.

  3. Alternative mounting media for preservation of some protozoa.

    Science.gov (United States)

    Criado-Fornelio, A; Heredero-Bermejo, I; Pérez-Serrano, J

    2014-10-01

    Protozoa resistant stages are disintegrated when mounted in toluene-based media. To overcome such problem, three toluene-free mountants were tested on preserve Acanthamoeba spp and gregarines. Two commercial glues based on cyanoacrylate or trimethoxysilane were suitable for preserving both cysts and trophozoites. Hoyer's medium showed good results for mounting gregarine oocysts. Copyright © 2014 Elsevier B.V. All rights reserved.

  4. Hole-thru-laminate mounting supports for photovoltaic modules

    Science.gov (United States)

    Wexler, Jason; Botkin, Jonathan; Culligan, Matthew; Detrick, Adam

    2015-02-17

    A mounting support for a photovoltaic module is described. The mounting support includes a pedestal having a surface adaptable to receive a flat side of a photovoltaic module laminate. A hole is disposed in the pedestal, the hole adaptable to receive a bolt or a pin used to couple the pedestal to the flat side of the photovoltaic module laminate.

  5. Solar electricity potentials and optimal angles for mounting solar ...

    African Journals Online (AJOL)

    The need for harnessing solar energy using solar panels mounted at optimal inclination angles in the six geopolitical zones of Nigeria is presented. The optimal angle for mounting solar panels as presented by Photovoltaic Geographic Information System (PVGIS) ranges from 11º to 14º in the Southern zone and 13º to 16º ...

  6. Wind instrument mountings for above-the-cab lookout exposure

    Science.gov (United States)

    Owen P. Cramer; Ralph H. Moltzau

    1968-01-01

    The lookout tower offers a ready-made platform from which the speed of true unobstructed wind can be measured, then reduced to equivalent of 20-foot wind. Tower-mounted instruments must meet the requirements of a lightning conductor system, but should also be easily installed and removed for storage and maintenance. Lightweight aluminum mountings for catwalk or flat-...

  7. The alpine flora of Mount Wilhelm (New Guinea)

    NARCIS (Netherlands)

    Hoogland, R.D.

    1958-01-01

    The flora of the higher mountains of New Guinea has been the object of several extensive collecting trips in the past forty years. Until quite recently, however, a serious gap in our knowledge was the very scanty information available from the area between Mount Wilhelmina in the West and Mount

  8. Programmed cell death

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The purpose of this conference to provide a multidisciplinary forum for exchange of state-of-the-art information on the role programmed cell death plays in normal development and homeostasis of many organisms. This volume contains abstracts of papers in the following areas: invertebrate development; immunology/neurology; bcl-2 family; biochemistry; programmed cell death in viruses; oncogenesis; vertebrate development; and diseases.

  9. BRAIN DEATH DIAGNOSIS

    Directory of Open Access Journals (Sweden)

    Calixto Machado

    2009-10-01

    Full Text Available Brain death (BD diagnosis should be established based on the following set of principles, i.e. excluding major confusing factors, identifying the cause of coma, determining irreversibility, and precisely testing brainstem reflexes at all levels of the brainstem. Nonetheless, most criteria for BD diagnosis do not mention that this is not the only way of diagnosing death. The Cuban Commission for the Determination of Death has emphasized the aforesaid three possible situations for diagnosing death: a outside intensive care environment (without life support physicians apply the cardio-circulatory and respiratory criteria; b in forensic medicine circumstances, physicians utilize cadaveric signs (they do not even need a stethoscope; c in the intensive care environment (with life support when cardiorespiratory arrest occurs physicians utilize the cardio-circulatory and respiratory criteria. This methodology of diagnosing death, based on finding any of the death signs, is not related to the concept that there are different types of death. The irreversible loss of cardio-circulatory and respiratory functions can only cause death when ischemia and anoxia are prolonged enough to produce an irreversible destruction of the brain. The sign of irreversible loss of brain functions, that is to say BD diagnosis, is fully reviewed.

  10. Simultaneous Optimization of Road Tolls and Tradable Credits in Public-private Mixed Networks

    Directory of Open Access Journals (Sweden)

    Nan Jiang

    2017-12-01

    Full Text Available This paper investigates a hybrid management policy of road tolls and tradable credits in mixed road networks with both public and private roads. In the public sub-network, a tradable credit scheme is applied to mitigate traffic congestion. In the private sub-network, tolls are collected by the private company, but the toll levels and toll locations are determined by the government. The purpose of toll charge is two-fold: on the one hand, the government uses it as a tool for mitigating congestion; on the other hand, a threshold of revenue should be guaranteed for the profitability of the private company. A bi-level programming model is formulated to minimize the total travel time in the network by taking into account the user equilibrium travel behaviour and the revenue requirement of private firms. To obtain a  global optimum solution, the bi-level model is transformed into an equivalent single-level mixed integer linear program that can be easily solved with commercial software. Numerical examples are provided to demonstrate the effectiveness of the developed model and the efficiency of the proposed algorithm. It is shown that the mixed management schemes can achieve favourable targets, namely, joint implementation of road tolls and tradable credits can effectively mitigate traffic congestion and meanwhile maintain reasonable revenue for the private company.

  11. Sudden cardiac death

    Directory of Open Access Journals (Sweden)

    Neeraj Parakh

    2015-01-01

    Full Text Available Sudden cardiac death is one of the most common cause of mortality worldwide. Despite significant advances in the medical science, there is little improvement in the sudden cardiac death related mortality. Coronary artery disease is the most common etiology behind sudden cardiac death, in the above 40 years population. Even in the apparently healthy population, there is a small percentage of patients dying from sudden cardiac death. Given the large denominator, this small percentage contributes to the largest burden of sudden cardiac death. Identification of this at risk group among the apparently healthy individual is a great challenge for the medical fraternity. This article looks into the causes and methods of preventing SCD and at some of the Indian data. Details of Brugada syndrome, Long QT syndrome, Genetics of SCD are discussed. Recent guidelines on many of these causes are summarised.

  12. Death with dignity

    Science.gov (United States)

    Allmark, P.

    2002-01-01

    The purpose of this article is to develop a conception of death with dignity and to examine whether it is vulnerable to the sort of criticisms that have been made of other conceptions. In this conception "death" is taken to apply to the process of dying; "dignity" is taken to be something that attaches to people because of their personal qualities. In particular, someone lives with dignity if they live well (in accordance with reason, as Aristotle would see it). It follows that health care professionals cannot confer on patients either dignity or death with dignity. They can, however, attempt to ensure that the patient dies without indignity. Indignities are affronts to human dignity, and include such things as serious pain and the exclusion of patients from involvement in decisions about their lives and deaths. This fairly modest conception of death with dignity avoids the traps of being overly subjective or of viewing the sick and helpless as "undignified". PMID:12161582

  13. Optimization of Classical Hydraulic Engine Mounts Based on RMS Method

    Directory of Open Access Journals (Sweden)

    J. Christopherson

    2005-01-01

    Full Text Available Based on RMS averaging of the frequency response functions of the absolute acceleration and relative displacement transmissibility, optimal parameters describing the hydraulic engine mount are determined to explain the internal mount geometry. More specifically, it is shown that a line of minima exists to define a relationship between the absolute acceleration and relative displacement transmissibility of a sprung mass using a hydraulic mount as a means of suspension. This line of minima is used to determine several optimal systems developed on the basis of different clearance requirements, hence different relative displacement requirements, and compare them by means of their respective acceleration and displacement transmissibility functions. In addition, the transient response of the mount to a step input is also investigated to show the effects of the optimization upon the time domain response of the hydraulic mount.

  14. Stimulation of Toll-like receptor-1/2 combined with Velcade increases cytotoxicity to human multiple myeloma cells

    International Nuclear Information System (INIS)

    Abdi, J; Mutis, T; Garssen, J; Redegeld, F

    2013-01-01

    An increasing body of evidence supports the important role of adhesion to bone marrow microenvironment components for survival and drug resistance of multiple myeloma (MM) cells. Previous studies suggested that stimulation of Toll-like receptors by endogenous ligands released during inflammation and tissue damage may be pro-tumorigenic, but no studies have been performed in relation to modulation of cell adhesion and drug cytotoxicity. Here, we investigated the effect of TLR1/2 activation on adhesion of human myeloma cells to fibronectin, and their sensitivity to the proteasome inhibitor Velcade. It was found that TLR1/2 activation with Pam3CSK4 increased the cytotoxicity of Velcade in L363, OPM-2 and U266 human myeloma cells. This effect was not related to a decreased adhesion of the cells to fibronectin, but TLR1/2 activation stimulated the caspase-3 activity in Velcade-treated myeloma cells, which may be responsible for the enhanced cell death. Inhibitors of NF-κB and MAPK reduced the stimulatory effect. These findings indicate that TLR activation of MM cells could bypass protective effects of cell adhesion and suggest that TLR signaling may also have antitumorigenic potential

  15. Mycobacterium avium MAV2052 protein induces apoptosis in murine macrophage cells through Toll-like receptor 4.

    Science.gov (United States)

    Lee, Kang-In; Choi, Han-Gyu; Son, Yeo-Jin; Whang, Jake; Kim, Kwangwook; Jeon, Heat Sal; Park, Hye-Soo; Back, Yong Woo; Choi, Seunga; Kim, Seong-Woo; Choi, Chul Hee; Kim, Hwa-Jung

    2016-04-01

    Mycobacterium avium and its sonic extracts induce apoptosis in macrophages. However, little is known about the M. avium components regulating macrophage apoptosis. In this study, using multidimensional fractionation, we identified MAV2052 protein, which induced macrophage apoptosis in M. avium culture filtrates. The recombinant MAV2052 induced macrophage apoptosis in a caspase-dependent manner. The loss of mitochondrial transmembrane potential (ΔΨm), mitochondrial translocation of Bax, and release of cytochrome c from mitochondria were observed in macrophages treated with MAV2052. Further, reactive oxygen species (ROS) production was required for the apoptosis induced by MAV2052. In addition, ROS and mitogen-activated protein kinases were involved in MAV2052-mediated TNF-α and IL-6 production. ROS-mediated activation of apoptosis signal-regulating kinase 1 (ASK1)-JNK pathway was a major signaling pathway for MAV2052-induced apoptosis. Moreover, MAV2052 bound to Toll-like receptor (TLR) 4 molecule and MAV2052-induced ROS production, ΔΨm loss, and apoptosis were all significantly reduced in TLR4(-/-) macrophages. Altogether, our results suggest that MAV2052 induces apoptotic cell death through TLR4 dependent ROS production and JNK pathway in murine macrophages.

  16. 23 CFR 661.49 - Can IRRBP funds be spent on Interstate, State Highway, and Toll Road IRR bridges?

    Science.gov (United States)

    2010-04-01

    ..., and Toll Road IRR bridges? 661.49 Section 661.49 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.49 Can IRRBP funds be spent on Interstate, State Highway, and Toll Road IRR bridges? Yes. Interstate...

  17. DMPD: Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15051069 Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Miy...ake K. Trends Microbiol. 2004 Apr;12(4):186-92. (.png) (.svg) (.html) (.csml) Show Innate recognition of lip...opolysaccharide by Toll-like receptor 4-MD-2. PubmedID 15051069 Title Innate recognition of lipopolysacchari

  18. 76 FR 46897 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

    Science.gov (United States)

    2011-08-03

    ... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Panel Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted....C. App. (1988) that an open meeting of the Taxpayer Advocacy Panel Small Business/Self Employed...

  19. 76 FR 6190 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

    Science.gov (United States)

    2011-02-03

    ... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Panel Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted....C. App. (1988) that an open meeting of the Taxpayer Advocacy Panel Small Business/Self Employed...

  20. 76 FR 37893 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

    Science.gov (United States)

    2011-06-28

    ... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Panel Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted....C. App. (1988) that an open meeting of the Taxpayer Advocacy Panel Small Business/Self Employed...

  1. 76 FR 17996 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

    Science.gov (United States)

    2011-03-31

    ... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted. The... Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer Advocacy Panel Small Business/Self...

  2. 76 FR 56880 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

    Science.gov (United States)

    2011-09-14

    ... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted. The...: Notice is hereby given pursuant to Section 10(a)(2) of the Federal Advisory Committee Act, 5 U.S.C. App...

  3. 76 FR 10942 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

    Science.gov (United States)

    2011-02-28

    ... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Panel Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted....C. App. (1988) that an open meeting of the Taxpayer Advocacy Panel Small Business/Self Employed...

  4. 76 FR 63716 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

    Science.gov (United States)

    2011-10-13

    ... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted. The...: Notice is hereby given pursuant to Section 10(a)(2) of the Federal Advisory Committee Act, 5 U.S.C. App...

  5. 76 FR 22170 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

    Science.gov (United States)

    2011-04-20

    ... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted. The... hereby given pursuant to Section 10(a)(2) of the Federal Advisory Committee Act, 5 U.S.C. App. (1988...

  6. 76 FR 2196 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

    Science.gov (United States)

    2011-01-12

    ... Small Business/Self Employed Correspondence Exam Toll Free AGENCY: Internal Revenue Service (IRS.../ Self Employed Correspondence Exam Toll Free will be conducted. The Taxpayer Advocacy Panel is... pursuant to Section 10(a)(2) of the Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open...

  7. DMPD: Glucocorticoids and the innate immune system: crosstalk with the toll-likereceptor signaling network. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17576036 Glucocorticoids and the innate immune system: crosstalk with the toll-like...07 May 13. (.png) (.svg) (.html) (.csml) Show Glucocorticoids and the innate immune system: crosstalk with t...nd the innate immune system: crosstalk with the toll-likereceptor signaling network. Authors Chinenov Y, Rog

  8. DMPD: Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation inrespiratory disease. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18031251 Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation inrespiratory...l) (.csml) Show Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation inrespiratory dis...utrophilic inflammation inrespiratory disease. Authors Sabroe I, Whyte MK. Publication Biochem Soc Trans. 20

  9. DMPD: MyDths and un-TOLLed truths: sensor, instructive and effector immunity totuberculosis. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18191460 MyDths and un-TOLLed truths: sensor, instructive and effector immunity totuberculosis...g) (.svg) (.html) (.csml) Show MyDths and un-TOLLed truths: sensor, instructive and effector immunity totuberculosis...e and effector immunity totuberculosis. Authors Reiling N, Ehlers S, Holscher C. Publication Immunol Lett. 2

  10. DMPD: Signaling to NF-kappaB by Toll-like receptors. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available l Med. 2007 Nov;13(11):460-9. Epub 2007 Oct 29. (.png) (.svg) (.html) (.csml) Show Signaling to NF-kappaB by Toll-like receptors. Pub...medID 18029230 Title Signaling to NF-kappaB by Toll-like receptors. Authors Kawai T

  11. DMPD: Innate immune sensing of pathogens and danger signals by cell surface Toll-likereceptors. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17275324 Innate immune sensing of pathogens and danger signals by cell surface Toll... Show Innate immune sensing of pathogens and danger signals by cell surface Toll-likereceptors. PubmedID 172...75324 Title Innate immune sensing of pathogens and danger signals by cell surface

  12. Perspective with Landsat Overlay, Mount Kilimanjaro, Tanzania

    Science.gov (United States)

    2002-01-01

    Mount Kilimanjaro (Kilima Njaro or 'shining mountain' in Swahili), the highest point in Africa, reaches 5,895 meters (19,340 feet) above sea level, tall enough to maintain a permanent snow cap despite being just 330 kilometers (210 miles) south of the equator. It is the tallest free-standing mountain on the Earth's land surface world, rising about 4,600 meters (15,000 feet) above the surrounding plain. Kilimanjaro is a triple volcano (has three peaks) that last erupted perhaps more than 100,000 years ago but still exudes volcanic gases. It is accompanied by about 20 other nearby volcanoes, some of which are seen to the west (left) in this view, prominently including Mount Meru, which last erupted only about a century ago. The volcanic mountain slopes are commonly fertile and support thick forests, while the much drier grasslands of the plains are home to elephants, lions, and other savanna wildlife.This 3-D perspective view was generated using topographic data from the Shuttle Radar Topography Mission (SRTM), a Landsat 7 satellite image, and a false sky. Topographic expression is vertically exaggerated two times.Landsat has been providing visible and infrared views of the Earth since 1972. SRTM elevation data matches the 30-meter (98-foot) resolution of most Landsat images and will substantially help in analyzing the large and growing Landsat image archive, managed by the U.S. Geological Survey (USGS).Elevation data used in this image was acquired by the Shuttle Radar Topography Mission (SRTM) aboard the Space Shuttle Endeavour, launched on Feb. 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect 3-D measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter (approximately 200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and

  13. Banner clouds observed at Mount Zugspitze

    Directory of Open Access Journals (Sweden)

    V. Wirth

    2012-04-01

    Full Text Available Systematic observations of banner clouds at Mount Zugspitze in the Bavarian Alps are presented and discussed. One set of observations draws on daily time lapse movies, which were taken over several years at this mountain. Identifying banner clouds with the help of these movies and using simultaneous observations of standard variables at the summit of the mountain provides climatological information regarding the banner clouds. In addition, a week-long measurement campaign with an entire suite of instruments was carried through yielding a comprehensive set of data for two specific banner cloud events.

    The duration of banner cloud events has a long-tailed distribution with a mean of about 40 min. The probability of occurrence has both a distinct diurnal and a distinct seasonal cycle, with a maximum in the afternoon and in the warm season, respectively. These cycles appear to correspond closely to analogous cycles of relative humidity, which maximize in the late afternoon and during the warm season. In addition, the dependence of banner cloud occurrence on wind speed is weak. Both results suggest that moisture conditions are a key factor for banner cloud occurrence. The distribution of wind direction during banner cloud events slightly deviates from climatology, suggesting an influence from the specific Zugspitz orography.

    The two banner cloud events during the campaign have a number of common features: the windward and the leeward side are characterized by different wind regimes, however, with mean upward flow on both sides; the leeward air is both moister and warmer than the windward air; the background atmosphere has an inversion just above the summit of Mt. Zugspitze; the lifting condensation level increases with altitude. The results are discussed, and it is argued that they are consistent with previous Large Eddy Simulations using idealized orography.

  14. Gravity Probe B Detector Mount Assembly

    Science.gov (United States)

    2004-01-01

    In this photo, the Gravity Probe B (GP-B) detector mount assembly is shown in comparison to the size of a dime. The assembly is used to detect exactly how much starlight is coming through different beams from the beam splitter in the telescope. The measurements from the tiny chips inside are what keeps GP-B aimed at the guide star. The GP-B is the relativity experiment developed at Stanford University to test two extraordinary predictions of Albert Einstein's general theory of relativity. The experiment will measure, very precisely, the expected tiny changes in the direction of the spin axes of four gyroscopes contained in an Earth-orbiting satellite at a 400-mile altitude. So free are the gyroscopes from disturbance that they will provide an almost perfect space-time reference system. They will measure how space and time are very slightly warped by the presence of the Earth, and, more profoundly, how the Earth's rotation very slightly drags space-time around with it. These effects, though small for the Earth, have far-reaching implications for the nature of matter and the structure of the Universe. GP-B is among the most thoroughly researched programs ever undertaken by NASA. This is the story of a scientific quest in which physicists and engineers have collaborated closely over many years. Inspired by their quest, they have invented a whole range of technologies that are already enlivening other branches of science and engineering. Launched April 20, 2004 , the GP-B program was managed for NASA by the Marshall Space Flight Center. Development of the GP-B is the responsibility of Stanford University along with major subcontractor Lockheed Martin Corporation. (Image credit to Paul Ehrensberger, Stanford University.)

  15. Installation of a Roof Mounted Photovoltaic System

    Science.gov (United States)

    Lam, M.

    2015-12-01

    In order to create a safe and comfortable environment for students to learn, a lot of electricity, which is generated from coal fired power plants, is used. Therefore, ISF Academy, a school in Hong Kong with approximately 1,500 students, will be installing a rooftop photovoltaic (PV) system with 302 solar panels. Not only will these panels be used to power a classroom, they will also serve as an educational opportunity for students to learn about the importance of renewable energy technology and its uses. There were four different options for the installation of the solar panels, and the final choice was made based on the loading capacity of the roof, considering the fact that overstressing the roof could prove to be a safety hazard. Moreover, due to consideration of the risk of typhoons in Hong Kong, the solar panel PV system will include concrete plinths as counterweights - but not so much that the roof would be severely overstressed. During and after the installation of the PV system, students involved would be able to do multiple calculations, such as determining the reduction of the school's carbon footprint. This can allow students to learn about the impact renewable energy can have on the environment. Another project students can participate in includes measuring the efficiency of the solar panels and how much power can be produced per year, which in turn can help with calculate the amount of money saved per year and when we will achieve economic parity. In short, the installation of the roof mounted PV system will not only be able to help save money for the school but also provide learning opportunities for students studying at the ISF Academy.

  16. Quasi-optical grill mounted in hyperguide

    International Nuclear Information System (INIS)

    Preinhaelter, J.

    1995-04-01

    A proposal is given of a new launcher of lower hybrid waves for the current drive in future big thermonuclear facilities operating in the 10 GHz frequency range. The principle has been combined of the quasi-optical grill with the concepts of the hyperguide and the multiinjection grill. As an example, a six rod structure model was optimized mounted in a oversized waveguide and irradiated by the oblique plane wave emerging in the form of a higher mode from an auxiliary oversized waveguide. The rods of the optimum structure have the elongated form of the cross-section with the resonant length in the direction of wave propagation equal to a multiple of the half-wavelength of the fundamental mode of the hyperguide. This row of rods forms a multiinjection grill with zero phase shift between waveguides. The second row of rods supporting the constructive superposition of the incident and doubly reflected waves enhances the efficiency of the structure. The optimum structure has a power spectrum with narrow peaks (the main N || =-2.15 and the parasitic N || =3.15), low power reflection (R tot =15%), high coupled power directivity (δ CP =70%), reasonable N || -weighted directivity (|δ CD w |=35%) and the peaking factor on the electric field equal to 3. Based on the optimization it is possible to design parameters of a big structure with tens of rods. The number of the construction elements of the structure can be reduced 20 times compared with the standard multijunction array. (author) 14 figs., 22 refs

  17. The Emotional Toll of Long-Term Unemployment: Examining the Interaction Effects of Gender and Marital Status

    Directory of Open Access Journals (Sweden)

    Gokce Basbug

    2017-04-01

    Full Text Available Prior research shows that long-term unemployment (LTU generates a negative emotional toll but leaves unexplored how such toll varies by gender and marital status. Using a mixed-methods approach we examine how the negative emotional toll of LTU is shaped by the interaction of gender and marital status. Our qualitative findings suggest that more unemployed married men than women experience marital tensions that exacerbate the emotional toll of unemployment. Our analysis of survey data show that while marriages improve the well-being of both unemployed men and women, for married men but not women such benefits disappear once we control for household income. These findings contribute to the existing literature by deepening our understanding of how gender and marital status mediate the emotional toll of LTU.

  18. DMPD: Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways inmacrophage activation. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17502339 Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways inmacrophage...May 14. (.png) (.svg) (.html) (.csml) Show Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways inmacrophage...T, Toll-like receptor, and ITAM-dependent pathways inmacrophage activation. Authors Hu X, Chen J, Wang L, Iv

  19. DMPD: Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs andCTRPs. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17681884 Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs an...ng) (.svg) (.html) (.csml) Show Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs andC...TRPs. PubmedID 17681884 Title Adipose tissue as an immunological organ: Toll-like

  20. DMPD: Toll-like receptors: from the discovery of NFkappaB to new insights intotranscriptional regulations in innate immunity. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 16930560 Toll-like receptors: from the discovery of NFkappaB to new insights intotr...2-13. Epub 2006 Aug 22. (.png) (.svg) (.html) (.csml) Show Toll-like receptors: from the discovery of NFkapp...6930560 Title Toll-like receptors: from the discovery of NFkappaB to new insights intotranscriptional regula

  1. DMPD: Toll-like receptors and the host defense against microbial pathogens: bringingspecificity to the innate-immune system. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15075354 Toll-like receptors and the host defense against microbial pathogens: brin...oc Biol. 2004 May;75(5):749-55. Epub 2004 Jan 14. (.png) (.svg) (.html) (.csml) Show Toll-like receptors and the host defense again...immune system. PubmedID 15075354 Title Toll-like receptors and the host defense against microbial pathogens:

  2. Suicide on Death Row.

    Science.gov (United States)

    Tartaro, Christine; Lester, David

    2016-11-01

    Despite the level of supervision of inmates on death row, their suicide rate is higher than both the male prison population in the United States and the population of males over the age of 14 in free society. This study presents suicide data for death row inmates from 1978 through 2010. For the years 1978 through 2010, suicide rates on death row were higher than that for the general population of males over the age of 15 and for state prisons for all but 2 years. © 2016 American Academy of Forensic Sciences.

  3. Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

    Science.gov (United States)

    Dunne, Aisling; Ejdeback, Mikael; Ludidi, Phumzile L; O'Neill, Luke A J; Gay, Nicholas J

    2003-10-17

    The Toll/interleukin 1 receptor (TIR) domain is a region found in the cytoplasmic tails of members of the Toll-like receptor/interleukin-1 receptor superfamily. The domain is essential for signaling and is also found in the adaptor proteins Mal (MyD88 adaptor-like) and MyD88, which function to couple activation of the receptor to downstream signaling components. Experimental structures of two Toll/interleukin 1 receptor domains reveal a alpha-beta-fold similar to that of the bacterial chemotaxis protein CheY, and other evidence suggests that the adaptors can make heterotypic interactions with both the receptors and themselves. Here we show that the purified TIR domains of Mal and MyD88 can form stable heterodimers and also that Mal homodimers and oligomers are dissociated in the presence of ATP. To identify structural features that may contribute to the formation of signaling complexes, we produced models of the TIR domains from human Toll-like receptor 4 (TLR4), Mal, and MyD88. We found that although the overall fold is conserved the electrostatic surface potentials are quite distinct. Docking studies of the models suggest that Mal and MyD88 bind to different regions in TLRs 2 and 4, a finding consistent with a cooperative role of the two adaptors in signaling. Mal and MyD88 are predicted to interact at a third non-overlapping site, suggesting that the receptor and adaptors may form heterotetrameric complexes. The theoretical model of the interactions is supported by experimental data from glutathione S-transferase pull-downs and co-immunoprecipitations. Neither theoretical nor experimental data suggest a direct role for the conserved proline in the BB-loop in the association of TLR4, Mal, and MyD88. Finally we show a sequence relationship between the Drosophila protein Tube and Mal that may indicate a functional equivalence of these two adaptors in the Drosophila and vertebrate Toll pathways.

  4. Apparent Brecciation Gradient, Mount Desert Island, Maine

    Science.gov (United States)

    Hawkins, A. T.; Johnson, S. E.

    2004-05-01

    Mount Desert Island, Maine, comprises a shallow level, Siluro-Devonian igneous complex surrounded by a distinctive breccia zone ("shatter zone" of Gilman and Chapman, 1988). The zone is very well exposed on the southern and eastern shores of the island and provides a unique opportunity to examine subvolcanic processes. The breccia of the Shatter Zone shows wide variation in percent matrix and clast, and may represent a spatial and temporal gradient in breccia formation due to a single eruptive or other catastrophic volcanic event. The shatter zone was divided into five developmental stages based on the extent of brecciation: Bar Harbor Formation, Sols Cliffs breccia, Seeley Road breccia, Dubois breccia, and Great Head breccia. A digital camera was employed to capture scale images of representative outcrops using a 0.5 m square Plexiglas frame. Individual images were joined in Adobe Photoshop to create a composite image of each outcrop. The composite photo was then exported to Adobe Illustrator, which was used to outline the clasts and produce a digital map of the outcrop for analysis. The fractal dimension (Fd) of each clast was calculated using NIH Image and a Euclidean distance mapping method described by Bérubé and Jébrak (1999) to quantify the morphology of the fragments, or the complexity of the outline. The more complex the fragment outline, the higher the fractal dimension, indicating that the fragment is less "mature" or has had less exposure to erosional processes, such as the injection of an igneous matrix. Sols Cliffs breccia has an average Fd of 1.125, whereas Great Head breccia has an average Fd of 1.040, with the stages between having intermediate values. The more complex clasts of the Sols Cliffs breccia with a small amount (26.38%) of matrix material suggests that it is the first stage in a sequence of brecciation ending at the more mature, matrix-supported (71.37%) breccia of Great Head. The results of this study will be used to guide isotopic

  5. Hitler's Death Camps.

    Science.gov (United States)

    Wieser, Paul

    1995-01-01

    Presents a high school lesson on Hitler's death camps and the widespread policy of brutality and oppression against European Jews. Includes student objectives, instructional procedures, and a chart listing the value of used clothing taken from the Jews. (CFR)

  6. Complications and Deaths - State

    Data.gov (United States)

    U.S. Department of Health & Human Services — Complications and deaths - state data. This data set includes state-level data for the hip/knee complication measure, the Agency for Healthcare Research and Quality...

  7. Eighth Amendment & Death Penalty.

    Science.gov (United States)

    Shortall, Joseph M.; Merrill, Denise W.

    1987-01-01

    Presents a lesson on capital punishment for juveniles based on three hypothetical cases. The goal of the lesson is to have students understand the complexities of decisions regarding the death penalty for juveniles. (JDH)

  8. Sudden Cardiac Death

    DEFF Research Database (Denmark)

    Risgaard, Bjarke; Winkel, Bo Gregers; Jabbari, Reza

    2017-01-01

    Objectives This study sought to describe the use of pharmacotherapy in a nationwide cohort of young patients with sudden cardiac death (SCD). Background Several drugs have been associated with an increased risk of SCD and sudden arrhythmic death syndrome (SADS). It remains unclear how...... pharmacotherapy may contribute to the overall burden of SCD in the general population. Methods This was a nationwide study that included all deaths that occurred between 2000 and 2009 and between 2007 and 2009 in people age 1 to 35 years and 36 to 49 years, respectively. Two physicians identified all SCDs through...... review of death certificates. Autopsy reports were collected. Pharmacotherapy prescribed within 90 days before SCD was identified in the Danish Registry of Medicinal Product Statistics. Results We identified 1,363 SCDs; median age was 38 years (interquartile range: 29 to 45 years), and 72% (n = 975) were men...

  9. Complications and Deaths - State

    Data.gov (United States)

    U.S. Department of Health & Human Services — Complications and deaths - state data. This data set includes state-level data for the hip/knee complication measure, the CMS Patient Safety Indicators, and 30-day...

  10. Orchestrating an Exceptional Death

    DEFF Research Database (Denmark)

    Jensen, Anja Marie Bornø

    processes of facing brain death and deciding about organ donation. This study suggests that organ donation should be understood as a ‘strange figure’ challenging traditions and attitudes regarding the boundaries between life and death and the practices surrounding dead human bodies. Simultaneously, organ...... donation can be comforting and furthermore enable some families to make sense of a sudden tragic death. Throughout the thesis, the concept of ‘orchestration’ serves as the overall theoretical framework to understand how families, hospital staff and, on a larger scale, Danish society attempt to perform......, reinterpret and translate death and organ donation into something culturally acceptable and sense making. With chapters focusing analytically on the performance of trust, the transformative practices of hope, the aesthetization of ambiguous bodies, the sociality of exchangeable organs and the organ donation...

  11. Existential concerns about death

    DEFF Research Database (Denmark)

    Moestrup, Lene

    2014-01-01

    Background Research suggests that addressing dying patients’ existential concerns can help improve their quality of life. Common existential conditions, such as a search for meaning and considerations about faith, are probably intensified in a palliative setting and existential concerns about death...... are likewise intensified when patients face their impending death. Knowledge of modern, secular existential concerns about death is under-researched, and therefore, it is difficult to develop and implement specifically targeted support to dying patients. Aim The aim of this paper is to present the results from...... a qualitative field study illuminating the variety of dying patients´ existential concerns about their impending death. Method Data was generated through ethnographic fieldwork comprising 17 semi-structured interviews with dying patients and 38 days of participant observation at three Danish hospices. Results...

  12. Life not death

    DEFF Research Database (Denmark)

    Milner, George R.; Boldsen, Jesper L.

    2017-01-01

    Analytically sophisticated paleoepidemiology is a relatively new development in the characterization of past life experiences. It is based on sound paleopathological observations, accurate age-at-death estimates, an explicit engagement with the nature of mortality samples, and analytical procedures...

  13. Complications and Deaths - Hospital

    Data.gov (United States)

    U.S. Department of Health & Human Services — Complications and deaths - provider data. This data set includes provider data for the hip/knee complication measure, CMS Patient Safety Indicators of serious...

  14. Complications and Deaths - National

    Data.gov (United States)

    U.S. Department of Health & Human Services — Complications and deaths - national data. This data set includes national-level data for the hip/knee complication measure, the CMS Patient Safety Indicators, and...

  15. Methods and apparatus for radially compliant component mounting

    Science.gov (United States)

    Bulman, David Edward [Cincinnati, OH; Darkins, Jr., Toby George; Stumpf, James Anthony [Columbus, IN; Schroder, Mark S [Greenville, SC; Lipinski, John Joseph [Simpsonville, SC

    2012-03-27

    Methods and apparatus for a mounting assembly for a liner of a gas turbine engine combustor are provided. The combustor includes a combustor liner and a radially outer annular flow sleeve. The mounting assembly includes an inner ring surrounding a radially outer surface of the liner and including a plurality of axially extending fingers. The mounting assembly also includes a radially outer ring coupled to the inner ring through a plurality of spacers that extend radially from a radially outer surface of the inner ring to the outer ring.

  16. Evaluation of implementation viability gap funding (VGF) policy on toll road investment in Indonesia

    Science.gov (United States)

    Mahani, Iris; Tamin, Rizal Z.; Pribadi, Krishna S.; Wibowo, Andreas

    2017-11-01

    VGF policy for toll road investment in Indonesia must be reviewed. Since 2012 the Government of Indonesia (GOI) has issued viability gap funding (VGF) policy for PPP infrastructure project through ministry of finance decision (PMK) No.223/2012. One of VGF purpose is to improve the financial feasibility. In the toll road investment in Indonesia, the implementation of this policy has some problems. This study aimed to evaluate the policy by seeking implementation constraints so can be given an alternative. This research was conducted qualitatively, included aspects of implementation process VGF policy. The analysis process is based on literature study and in-depth interviews to related parties include business entity, ministry of finance, and the ministry of public works, Indonesia Toll Road Authority (BPJT) and professional societies. The literature review conducted by reviewing existing policies and best practices in countries that already practice VGF. The conclusion of this study are 1) There is a conflict of regulation in viability gap funding (VGF) for toll road investment in Indonesia; 2) If Government of Indonesia (GOI) want implement construction grant as VGF, so the regulation must improve in time limited for submission and clearly define limited given in regulation; 3) If GOI want implement partial construction as VGF, so the regulation must be improve in guideline for submission and given.

  17. Sound Toll Registers Online and the eighteenth century Baltic coffee commerce

    NARCIS (Netherlands)

    Veluwenkamp, Jan; Draper, Maarten

    2014-01-01

    The ‘Sound Toll Registers Online’ project of the University of Groningen is the subject of this article. Jan Willem Veluwenkamp and Maarten Draper discuss the history, aims and achievements of the project. The possibilities and prospects of this new source are illustrated by a case study on Baltic

  18. Reptile Toll-like receptor 5 unveils adaptive evolution of bacterial flagellin recognition

    NARCIS (Netherlands)

    Voogdt, Carlos G.P.; Bouwman, Lieneke I.; Kik, Marja J.L.; Wagenaar, Jaap A.; Putten, Van Jos P.M.

    2016-01-01

    Toll-like receptors (TLR) are ancient innate immune receptors crucial for immune homeostasis and protection against infection. TLRs are present in mammals, birds, amphibians and fish but have not been functionally characterized in reptiles despite the central position of this animal class in

  19. Reptile Toll-like receptor 5 unveils adaptive evolution of bacterial flagellin recognition

    NARCIS (Netherlands)

    Voogdt, Carlos G P|info:eu-repo/dai/nl/413535169; Bouwman, Lieneke I|info:eu-repo/dai/nl/341590797; Kik, Marja J L|info:eu-repo/dai/nl/080432565; Wagenaar, Jaap A|info:eu-repo/dai/nl/126613354; van Putten, Jos P M|info:eu-repo/dai/nl/069916527

    2016-01-01

    Toll-like receptors (TLR) are ancient innate immune receptors crucial for immune homeostasis and protection against infection. TLRs are present in mammals, birds, amphibians and fish but have not been functionally characterized in reptiles despite the central position of this animal class in

  20. Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

    Science.gov (United States)

    Chronic low-grade inflammation is a hallmark of obesity and thought to contribute to the development of obesity-related insulin resistance. Toll-like receptor 4 (Tlr4) is a key mediator of pro-inflammatory responses. Mice lacking Tlr4s are protected from diet-induced insulin resistance and inflammat...

  1. First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds

    Czech Academy of Sciences Publication Activity Database

    Bainová, H.; Králová, Tereza; Bryjová, Anna; Albrecht, Tomáš; Bryja, Josef; Vinkler, M.

    2014-01-01

    Roč. 45, č. 1 (2014), s. 151-155 ISSN 0145-305X R&D Projects: GA ČR GAP505/10/1871 Institutional support: RVO:68081766 Keywords : Birds * Expression * Innate immunity * Toll-like receptor 5 * Pseudogene * Flagellin Subject RIV: EG - Zoology Impact factor: 2.815, year: 2014

  2. Combating Drug Abuse by Targeting Toll-Like Receptor 4 (TLR)

    Science.gov (United States)

    2015-12-01

    the treatment of addiction . 2. Keywords Drug reward Addiction Opioid Morphine Heroine Cocaine Dopamine Mesolimbic dopamine pathway...there is some other less selective explanation for this phenomenon. Current pharmacological treatments for opioid addiction /abuse tend to be only...toll like receptor 4 in both opioid and cocaine reward / reinforcement. In addition it has successfully documented the potential of (+)naltrexone (a

  3. Developing Road Infrastructure Route Planning: Increasing Feasibility of Toll Road Project

    Directory of Open Access Journals (Sweden)

    Mohammed Ali Berawi

    2016-12-01

    Full Text Available Indonesian government attempts to improve connectivity and to increase regional activities in SumateraIsland through the development of Trans Sumatera Toll Road (TSTR.However, despite its benefits to local economic development in Sumatera, the project shows low feasibility due to a low amount of investment. It can be attributed from the lack of planning in the initial phase to produce a comprehensive route that considers the various potentials of the regions. Thus, this research aims to investigate alternative routeplanning of Trans Sumatera Toll Road particularly in this paper for Central Sumatera by studying Gross Regional Domestic Product (GRDP, population and other significant factors. This research exposes cities and districts in Riau, West Sumatera, and Jambi which potentially contribute to the regional economy. Each selected towns and districts will be integrated with the intermodal system and connected to other functions to establish the Trans Sumatera Toll Roadproject in Central Sumatera. Compared to existing estimation of investment from public records, this alternative route has generated a competitive cost of investment which is estimated around 118,053,400,074,696 rupiahs. The research findings are expected to become the basis to improve other similar infrastructure toll road project development.

  4. Synthesis and evaluation of peptide and nucleic acid based Toll-like receptor ligands

    NARCIS (Netherlands)

    Weterings, Josephus Johannes

    2008-01-01

    Toll-like receptors (TLRs) are receptors that continuously scour their direct surroundings for pathogen associated molecular patterns (PAMPs) of bacterial, viral or fungal origin. TLRs can be found at cells that play a role in the immune system. Binding of the TLR with its corresponding ligand

  5. Structure-based drug design approach to target toll-like receptor ...

    African Journals Online (AJOL)

    Toll-like receptor (TLR) signaling pathways are the first line of defence against many microbial organisms. The question of how TLRs recognize endogenous ligands remains controversial. Several studies have shown that TLRs are implicated in the pathogenesis of autoimmune diseases such as systemic lupus ...

  6. Toll-like receptors in the pathogenesis of human B cell malignancies

    NARCIS (Netherlands)

    Isaza-Correa, Johana M.; Liang, Zheng; van den Berg, Anke; Diepstra, Arjan; Visser, Lydia

    2014-01-01

    Toll-like receptors (TLRs) are important players in B-cell activation, maturation and memory and may be involved in the pathogenesis of B-cell lymphomas. Accumulating studies show differential expression in this heterogeneous group of cancers. Stimulation with TLR specific ligands, or agonists of

  7. 47 CFR 43.53 - Reports regarding division of international toll communication charges.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Reports regarding division of international... AFFILIATES § 43.53 Reports regarding division of international toll communication charges. (a) Each... between the continental United States and any foreign country (other than one to which the domestic word...

  8. Toll-like receptor and associated regulators in pneumonia and sepsis

    NARCIS (Netherlands)

    Blok, D.C.

    2015-01-01

    Humanity struggles against micro-organism invasion on a daily basis. Innate immunity is part of the first line of defense when it comes to preventing infection, signaling a perceived health threat and eliminating microbes before they can cause harm. Toll-like receptors (TLRs) and other pattern

  9. Activation of toll-like receptors 2 and 4 by gram-negative periodontal bacteria

    NARCIS (Netherlands)

    Kikkert, R.; Laine, M. L.; Aarden, L. A.; van Winkelhoff, A. J.

    2007-01-01

    BACKGROUND/AIMS: Periodontitis is a chronic infectious disease associated with a gram-negative subgingival microflora. Bacterial components stimulate, among other receptors, Toll-like receptor (TLR) 2 and/or TLR4. Accumulating evidence indicates that both qualitatively and quantitatively distinct

  10. Toll-like receptors as targets for inflammation, development and repair in the central nervous system

    NARCIS (Netherlands)

    Noort, J.M. van

    2007-01-01

    Toll-like receptors (TLRs) that play key roles in inflammation are also widely expressed in the CNS. While they are well known to activate inflammatory responses to microbial products, TLRs fulfill additional roles in the absence of infection. Emerging evidence suggests that several TLRs play a role

  11. MECHANISMS OF ANTIINFECTIOUS FUNCTIONS OF INNATE IMMUNITY: ROLE OF TOLL-LIKE RECEPTORS

    Directory of Open Access Journals (Sweden)

    S. I. Suskov

    2012-01-01

    Full Text Available This review describes the main role of toll-like receptors of innate immunity for pathogen recognition; signaling; production of inflammatory response. Also Interrelation of innate and adaptive Immunity in conditions of pathology and organ transplantation were considered. 

  12. Role of toll like receptors in bacterial and viral diseases – A ...

    African Journals Online (AJOL)

    Avishek Das

    2017-05-20

    May 20, 2017 ... Background: Toll like receptors are key-receptors of the innate immune system, but their role against bacterial and viral infections are yet to be understood. Aim: The present study is aimed to investigate the diversity and frequency distribution of 10 TLR genes among typhoid fever and HIV+ patients. In this ...

  13. Activation of toll-like receptors and dendritic cells by a broad range of bacterial molecules

    NARCIS (Netherlands)

    Boele, L.C.L.; Bajramovic, J.J.; Vries, A.M.M.B.C. de; Voskamp-Visser, I.A.I.; Kaman, W.E.; Kleij, D. van der

    2009-01-01

    Activation of pattern recognition receptors such as Toll-like receptors (TLRs) by pathogens leads to activation and maturation of dendritic cells (DC), which orchestrate the development of the adaptive immune response. To create an overview of the effects of a broad range of pathogenic bacteria,

  14. For Whom the Bell Tolls (and Nods): Spit-acular Saliva

    Czech Academy of Sciences Publication Activity Database

    Shaw, D.K.; Kotsyfakis, Michalis; Pedra, J. H. F.

    2016-01-01

    Roč. 3, č. 2 (2016), s. 40-50 E-ISSN 2196-3045 Institutional support: RVO:60077344 Keywords : tick-borne diseases * tick saliva * innate immune signaling * toll-like receptor (TLR) * nod-like receptor (NLR) Subject RIV: EC - Immunology

  15. Online Education as a Toll Good: An Examination of the South Carolina Virtual School Program

    Science.gov (United States)

    Rauh, Jonathan

    2011-01-01

    Education has long been considered merit good; however, inequitable distribution has made it more akin to a toll good. This was most recently demonstrated by Henry, Fortner, and Thompson (2010). Choice requirements designed to remedy the inequitable distribution of education, have largely been confined to brick and mortar schools. Subsequently,…

  16. The Role of Toll-Like Receptor 2 in Inflammation and Fibrosis during Progressive Renal Injury

    NARCIS (Netherlands)

    Leemans, Jaklien C.; Butter, Loes M.; Pulskens, Wilco P. C.; Teske, Gwendoline J. D.; Claessen, Nike; van der Poll, Tom; Florquin, Sandrine

    2009-01-01

    Tissue fibrosis and chronic inflammation are common causes of progressive organ damage, including progressive renal disease, leading to loss of physiological functions. Recently, it was shown that Toll-like receptor 2 (TLR2) is expressed in the kidney and activated by endogenous danger signals. The

  17. Role of toll like receptors in bacterial and viral diseases – A systemic ...

    African Journals Online (AJOL)

    Background: Toll like receptors are key-receptors of the innate immune system, but their role against bacterial and viral infections are yet to be understood. Aim: The present study is aimed to investigate the diversity and frequency distribution of 10 TLR genes among typhoid fever and HIV+ patients. In this study, 44 samples ...

  18. Toll-like receptor 4 plays a protective role in pulmonary tuberculosis in mice

    NARCIS (Netherlands)

    Branger, Judith; Leemans, Jaklien C.; Florquin, Sandrine; Weijer, Sebastiaan; Speelman, Peter; van der Poll, Tom

    2004-01-01

    Toll-like receptors (TLR) play an essential role in the innate recognition of microorganisms by the host. To determine the role of TLR4 in host defense against lung tuberculosis, TLR4 mutant (C3H/HeJ) and wild-type (C3H/HeN) mice were intranasally infected with live Mycobacterium tuberculosis. TLR4

  19. Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish.

    NARCIS (Netherlands)

    Meijer, A.H.; Krens, SF Gabby; Rodriguez, IA Medina; He, S; Bitter, W.; Snaar-Jagalska, B Ewa; Spaink, H.P.

    2004-01-01

    The zebrafish genomic sequence database was analysed for the presence of genes encoding members of the Toll-like receptors (TLR) and interleukin receptors (IL-R) and associated adaptor proteins containing a TIR domain. The resulting predictions show the presence of one or more counterparts for the

  20. PECULIARITIES OF ASSIGNMENT OF ROLLING BEARING MOUNTING AND PARAMETERS OF GEOMETRIC ACCURACY OF MOUNTING SURFACES OF SHAFTS AND FRAMES

    Directory of Open Access Journals (Sweden)

    Adamenko Yu. І.

    2017-04-01

    Full Text Available The standards and methods concerning assignment of rolling bearing fit with shafts and frames via example of bearing 6-208 are analyzed. We set certain differences of recommendations according to GOST 3325-85, "Rolling bearings. Tolerance zones and technical requirements to mounting surfaces of shafts and frames. Attachment" and by reference of rolling bearing manufacturers. The following factors should be taken into consideration when assigning the mounting with the tension the internal ring of the bearing with shaft and mounting with a gap in the outer ring with a housing bore. The methods of achieving accuracy of mounting surfaces of shafts and frames via form tolerance assignment: roundness tolerance, profile of longitudinal cut, cross section, cylindricity and others. It is possible to limit the bearing rings in different ways, for example appointing the cylindrical mounting surfaces and bead end surfaces the appropriate tolerances, namely: coaxiality tolerance or full radial beat of mounting surfaces, and also perpendicularity tolerance, butt beats and full butt beats of mounting end surfaces. We suggest to expand methods of achieving the accuracy of shafts and frames depending on seriation of production and production operations metrology support.

  1. XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

    DEFF Research Database (Denmark)

    Yabal, Monica; Müller, Nicole; Adler, Heiko

    2014-01-01

    of XIAP or deletion of its RING domain lead to excessive cell death and IL-1β secretion from dendritic cells triggered by diverse Toll-like receptor stimuli. Aberrant IL-1β secretion is TNF dependent and requires RIP3 but is independent of cIAP1/cIAP2. The observed cell death also requires TNF and RIP3...... but proceeds independently of caspase-1/caspase-11 or caspase-8 function. Loss of XIAP results in aberrantly elevated ubiquitylation of RIP1 outside of TNFR complex I. Virally infected Xiap(-/-) mice present with symptoms reminiscent of XLP-2. Our data show that XIAP controls RIP3-dependent cell death and IL-1...

  2. CDC WONDER: Mortality - Infant Deaths

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Mortality - Infant Deaths (from Linked Birth / Infant Death Records) online databases on CDC WONDER provide counts and rates for deaths of children under 1 year...

  3. Mechanical Design of an Omni-Directional Sensor Mount

    National Research Council Canada - National Science Library

    Rosheim, Mark

    2002-01-01

    This effort has been directed to development and demonstration of a gimbal mount capable of 180 degree singularity- free pitch and yaw motion about a two-axis center, avoiding the common problem of gimbal lock...

  4. Rapid mounting of adult Drosophila structures in Hoyer's medium.

    Science.gov (United States)

    Stern, David L; Sucena, Elio

    2012-01-01

    The Drosophila cuticle carries a rich array of morphological details. Thus, cuticle examination has had a central role in the history of genetics. This protocol describes a procedure for mounting adult cuticles in Hoyer's medium, a useful mountant for both larval and adult cuticles. The medium digests soft tissues rapidly, leaving the cuticle cleared for observation. In addition, samples can be transferred directly from water to Hoyer's medium. However, specimens mounted in Hoyer's medium degrade over time. For example, the fine denticles on the larval dorsum are best observed soon after mounting; they begin to fade after 1 week, and can disappear completely after several months. More robust features, such as the ventral denticle belts, will persist for a longer period of time. Because adults cannot profitably be mounted whole in Hoyer's medium, some dissection is necessary.

  5. Application of Evolutionary Computation in Automotive Powertrain Mount Tuning

    Directory of Open Access Journals (Sweden)

    Anab Akanda

    2006-01-01

    Full Text Available Engine mount tuning is a multi-disciplinary exercise since it affects Idle-shake, Road-shake and power-train noise response. Engine inertia is often used as a tuned absorber for controlling suspension resonance related road-shake issues. Last but not least, vehicle ride and handling may also be affected by mount tuning. In this work, Torque-Roll-Axis (TRA decoupling of the rigid powertrain was used as a starting point for mount tuning. Nodal point of flexible powertrain bending was used to define the envelop for transmission mount locations. The frequency corresponding to the decoupled roll mode of the rigid powertrain was then adjusted for idle-shake and road-shake response management.

  6. A vehicle mounted scintillation ratemeter for environmental survey

    International Nuclear Information System (INIS)

    Cavell, I.W.

    1960-01-01

    An improved method of mounting an existing environmental gamma survey equipment in a vehicle is described. Performance data for the equipment is given and some typical radiometric traces obtained at A.E.E. Winfrith given. (author)

  7. Low radioactivity material for use in mounting radiation detectors

    Science.gov (United States)

    Fong, Marshall; Metzger, Albert E.; Fox, Richard L.

    1988-01-01

    Two materials, sapphire and synthetic quartz, have been found for use in Ge detector mounting assemblies. These materials combine desirable mechanical, thermal, and electrical properties with the radioactive cleanliness required to detect minimal amounts of K, Th, and U.

  8. How Mount Stromlo Observatory shed its imperial beginnings

    Science.gov (United States)

    Bhathal, Ragbir

    2014-12-01

    In the 90 years since its foundation in 1924, Mount Stromlo Observatory in Australia has changed from an outpost of empire to an international research institution. Ragbir Bhathal examines how the British influence waxed and waned.

  9. Fathead minnow whole-mount in situ hybridization (WISH)

    Data.gov (United States)

    U.S. Environmental Protection Agency — This study demonstrates the potential of whole-mount in situ hybridization (WISH), in conjunction with quantitative real-time polymerase chain reaction (QPCR)...

  10. A Surface-Mounted Rotor State Sensing System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — A surface-mounted instrumentation system for measuring rotor blade motions on rotorcraft, for use both in flight and in wind tunnel testing, is proposed for...

  11. [Deaths in hotels].

    Science.gov (United States)

    Risse, Manfred; Weilbächer, Nadine; Birngruber, Christoph; Verhoff, Marcel A

    2010-01-01

    There are no verified statistics about deaths occurring in hotels, and only a few cases have been described in the literature. A recent case induced us to conduct a systematic search for deaths in hotels in the autopsy reports of the Institute of Legal Medicine in Giessen for the period from 1968 to 2009. This search yielded 22 evaluable cases in which persons had been found dead or had died in hotels. Data evaluated in the study were sex and age of the deceased, reason for the stay in the hotel and cause of death. Among the deaths, 18 were males and 4 females and the average age was 41 and 40 years respectively. 6 of the male guests had died from a natural and 10 from a non-natural cause. In the remaining two cases, the cause of death could not be determined, but as there was no evidence that another party had been involved, the cases were not further investigated. Of the 4 female guests, 3 had died of a natural cause; in one case, the cause of death remained unclear even after morphological and toxicological investigations. Surprisingly, a third of the men were found to be temporarily living in hotels due to social circumstances. This was not true for any of the women. Our retrospective analysis is based on a comparatively small number of deaths in what were mostly hotels in small to medium-sized towns. Interestingly, the gender ratio of 18:4 for deceased men and women was significantly higher than the usual gender ratio of 2:1 found for forensic autopsies. To be able to draw further conclusions, a greater number of cases would have to be analysed, for example by recruiting additional case files from other institutes of legal medicine. This would also open up the option of investigating possible regional variations.

  12. Taking Charge: Walter Sydney Adams and the Mount Wilson Observatory

    Science.gov (United States)

    Brashear, R.

    2004-12-01

    The growing preeminence of American observational astronomy in the first half of the 20th century is a well-known story and much credit is given to George Ellery Hale and his skill as an observatory-building entrepreneur. But a key figure who has yet to be discussed in great detail is Walter Sydney Adams (1876-1956), Hale's Assistant Director at Mount Wilson Observatory. Due to Hale's illnesses, Adams was Acting Director for much of Hale's tenure, and he became the second Director of Mount Wilson from 1923 to 1946. Behind his New England reserve Adams was instrumental in the growth of Mount Wilson and thus American astronomy in general. Adams was hand-picked by Hale to take charge of stellar spectroscopy work at Yerkes and Mount Wilson and the younger astronomer showed tremendous loyalty to Hale and Hale's vision throughout his career. As Adams assumed the leadership role at Mount Wilson he concentrated on making the observatory a place where researchers worked with great freedom but maintain a high level of cooperation. This paper will concentrate on Adams's early years and look at his growing relationship with Hale and how he came to be the central figure in the early history of Mount Wilson as both a solar and stellar observatory. His education, his years at Dartmouth and Yerkes (including his unfortunate encounter with epsilon Leonis), and his formative years on Mount Wilson are all important in learning how he shaped the direction of Mount Wilson and the development of American astronomy in the first half of the 20th century. This latter history cannot be complete until we bring Adams into better focus.

  13. Some technical solutions on organization and technology of reactor room component mounting

    International Nuclear Information System (INIS)

    Romanovskij, V.I.

    1982-01-01

    Design of the production equipment for mounting sites of heat facilities of the Zaporozhe NPP is considered. Plan of the production equipment for mounting sites of heat facilities and flowsheet of mounting of supporting truss of the reactor are presented

  14. National Ingition Facility subsystem design requirements optical mounts SSDR 1.4.4

    International Nuclear Information System (INIS)

    Richardson, M.

    1996-01-01

    This SSDR establishes the performance, design, development and test requirements for NIF Beam Transport Optomechanical Subsystems. optomechanical Subsystems includes the mounts for the beam transport mirrors, LMl - LM8, the polarizer mount, and the spatial filter lens mounts

  15. New active machine tool drive mounting on the frame

    Directory of Open Access Journals (Sweden)

    Švéda J.

    2007-10-01

    Full Text Available The paper deals with the new active mounting of the machine tool drives. The commonly used machine tools are at this time mainly equipped with fix-mounting of the feed drives. This structure causes full transmission of the force shocks to the machine bed and thereby restricts the dynamic properties of the motion axis and the whole machine. The spring-mounting of the feed drives is one of the possibilities how to partially suppress the vibrations. The force that reacts to the machine tool bed is transformed thereby the vibrations are lightly reduced. Unfortunately the transformation is not fully controlled. The new active mounting of the machine tool drives allows to fully control the force behaviour that react to the machine body. Thereby the number of excited frequencies on the machine tool bed is significantly reduced. The active variant of the feed drive mounting is characterized by the synergistic cooperation between two series-connected actuators (“motor on motor”. The paper briefly describes design, control techniques and optimization of the feed drives with the new active mounting conception.

  16. Life and death.

    Science.gov (United States)

    Lloyd, J W

    1983-03-01

    In contrast with the other lectures given in the course on humanics and bioethics at the UOEH, which address the questions of life and death from the standpoint of the physician or the philosopher, this lecture considers these issues as seen by the cancer patient who has had a close encounter with death. The attitudes of Americans concerning abortion, the use of life-support systems, "mercy killings", suicide and the use of cancer chemotherapy are discussed with particular emphasis on restraints imposed by the courts, the churches and the family systems. An attempt is made to contrast the American and Japanese attitudes on these questions but this is difficult because of different cultural and religious backgrounds. The author describes his own experiences as a cancer patient who has approached death very closely and the changes in his own attitude toward life which results from the encounter with death. He also talks about the joy of being alive and describes his own experience with receiving cancer chemotherapy, the resulting discomfort and inconveniences and his feelings about a "tolerable" existence. Finally, the author considers the question of the "quality of life" for the cancer patient who has a violent reaction to certain forms of chemotherapy. This is a dilemma for the patient and the doctor who must consider the choice between death and a miserable existence.

  17. Malnutrition related deaths.

    Science.gov (United States)

    Sparre-Sørensen, Maja; Kristensen, Gustav N

    2016-10-01

    Studies have shown that malnutrition increases the risk of morbidity, mortality, the length of hospital stay, and costs in the elderly population. Approximately one third of all patients admitted to geriatric wards in Denmark are malnourished according to the Danish Geriatric database. The aim of this study is to describe and examine the sudden increase in deaths due to malnutrition in the elderly population in Denmark from 1999 and, similarly, the sudden decline in malnutrition related deaths in 2007. A descriptive epidemiologic study was performed. All Danes listed in the national death registry who died from malnutrition in the period from 1994 to 2012 are included. The number of deaths from malnutrition increased significantly during the period from 1999 to 2007, especially in the age group 70 years and over. Additionally, we document a surprising similarity between the development in excess mortality from malnutrition in the five Danish regions during the same period. During the period 1999-2007 malnutrition was the direct cause of 340 extra deaths, and probably ten times more registered under other diseases. This development in excess mortality runs parallel in all five Danish regions over time. Copyright © 2016 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.

  18. Concept of 'bad death'

    Directory of Open Access Journals (Sweden)

    Marija Vučković

    2016-02-01

    Full Text Available Following previous research on the linguistic concept of а 'bad death' which lexical expression is the word family of the verb ginuti, I focus my attention in this paper on the relationship between language conceptualization of а 'bad death' and the representation of а 'bad death' in traditional and contemporary culture. Diachronically based language corpus makes possible to trace the changes of referential frame and use of verb ginuti and its derivatives. In the traditional culture а 'bad death' is marked in action code by irregular way of burial and beliefs in demons stemming from the 'impure dead'. In the paper I explore the degree of synonymy of the symbols of all three codes: verbal code, action code and code of beliefs. In the contemporary culture the lack of individual control and choice is considered to be the key element of the concept of a 'bad death'. This change of conceptual content manifests itself in the use of its lexical expressions.

  19. Precisely Tracking Childhood Death.

    Science.gov (United States)

    Farag, Tamer H; Koplan, Jeffrey P; Breiman, Robert F; Madhi, Shabir A; Heaton, Penny M; Mundel, Trevor; Ordi, Jaume; Bassat, Quique; Menendez, Clara; Dowell, Scott F

    2017-07-01

    Little is known about the specific causes of neonatal and under-five childhood death in high-mortality geographic regions due to a lack of primary data and dependence on inaccurate tools, such as verbal autopsy. To meet the ambitious new Sustainable Development Goal 3.2 to eliminate preventable child mortality in every country, better approaches are needed to precisely determine specific causes of death so that prevention and treatment interventions can be strengthened and focused. Minimally invasive tissue sampling (MITS) is a technique that uses needle-based postmortem sampling, followed by advanced histopathology and microbiology to definitely determine cause of death. The Bill & Melinda Gates Foundation is supporting a new surveillance system called the Child Health and Mortality Prevention Surveillance network, which will determine cause of death using MITS in combination with other information, and yield cause-specific population-based mortality rates, eventually in up to 12-15 sites in sub-Saharan Africa and south Asia. However, the Gates Foundation funding alone is not enough. We call on governments, other funders, and international stakeholders to expand the use of pathology-based cause of death determination to provide the information needed to end preventable childhood mortality.

  20. [Reflections on prehospitalisation deaths].

    Science.gov (United States)

    Hugenschmitt, Delphine; Allonneau, Alexandre; Cesareo, Éric; Gueugniaud, Pierre-Yves; Lefort, Hugues

    2017-12-01

    In the past, death was a family and community affair, but today it is institutional and entrusted to healthcare personnel. Thanks to a questionnaire on their feelings about prehospitalisation deaths, the experience and training needs for healthcare personnel at a mobile emergency and intensive care service were analysed. The majority of these professionals had been confronted with difficulties when faced with prehospitalisation deaths. There is little understanding of religious rites, even though this is an important point in dealing with the situation. There is a strong desire for training. The pedagogical support offered in response to the needs expressed was recognised as being useful and should be more widespread. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  1. Amphetamine derivative related deaths.

    Science.gov (United States)

    Lora-Tamayo, C; Tena, T; Rodríguez, A

    1997-02-28

    Amphetamine its methylendioxy (methylendioxyamphetamine methylenedioxymethylamphetamine, methylenedioxyethylamphetamine) and methoxy derivatives (p-methoxyamphetamine and p-methoxymethylamphetamine) are widely abused in Spanish society. We present here the results of a systematic study of all cases of deaths brought to the attention of the Madrid department of the Instituto Nacional de Toxicologia from 1993 to 1995 in which some of these drugs have been found in the cadaveric blood. The cases were divided into three categories: amphetamine and derivatives, amphetamines and alcohol, amphetamines and other drugs. Data on age, sex, clinical symptoms, morphological findings, circumstances of death, when known, and concentration of amphetamine derivatives, alcohol and other drugs in blood are given for each group. The information provided here may prove to be useful for the forensic interpretation of deaths which are directly or indirectly related to abuse of amphetamine derivatives.

  2. Competing causes of death: a death certificate study

    NARCIS (Netherlands)

    Mackenbach, J. P.; Kunst, A. E.; Lautenbach, H.; Oei, Y. B.; Bijlsma, F.

    1997-01-01

    BACKGROUND: Despite the widespread interest in competing causes of death, empirical information on interrelationships between causes of death is scarce. We have used death certificate information to estimate the prevalence of competing causes of death at the moment of dying from specific underlying

  3. [Maternal death: unequal risks].

    Science.gov (United States)

    Defossez, A C; Fassin, D

    1989-01-01

    Nearly 99% of maternal deaths in the world each year occur in developing countries. New efforts have recently been undertaken to combat maternal mortality through research and action. The medical causes of such deaths are coming to be better understood, but the social mechanisms remain poorly grasped. Maternal mortality rates in developing countries are difficult to interpret because they tend to exclude all deaths not occurring in health care facilities. The countries of Europe and North America have an average maternal mortality rate of 30/100,000 live births, representing about 6000 deaths each year. The developing countries of Asia, Africa, and Latin America have rates of 270-640/100,000, representing some 492,000 deaths annually. For a true comparison of the risks of maternal mortality in different countries, the risk itself and the average number of children per woman must both be considered. A Nigerian woman has 375 times greater risk of maternal death than a Swedish woman, but since she has about 4 times more children, her lifetime risk of maternal death is over 1500 times greater than that of the Swedish woman. The principal medical causes of maternal death are known: hemorrhages due to placenta previa or retroplacental hematoma, mechanical dystocias responsible for uterine rupture, toxemia with eclampsia, septicemia, and malaria. The exact weight of abortion in maternal mortality is not known but is probably large. The possible measures for improving such rates are of 3 types: control of fertility to avoid early, late, or closely spaced pregnancies; effective medical surveillance of the pregnancy to reduce the risk of malaria, toxemia, and hemorrhage, and delivery in an obstetrical facility, especially for high-risk pregnancies. Differential access to high quality health care explains much of the difference between mortality rates in urban and rural, wealthy and impoverished areas of the same country. The social determinants of high maternal mortality

  4. Death with dignity

    OpenAIRE

    Allmark, P.

    2002-01-01

    The purpose of this article is to develop a conception of death with dignity and to examine whether it is vulnerable to the sort of criticisms that have been made of other conceptions. In this conception "death" is taken to apply to the process of dying; "dignity" is taken to be something that attaches to people because of their personal qualities. In particular, someone lives with dignity if they live well (in accordance with reason, as Aristotle would see it). It follows that health care pr...

  5. UHV mirror mounts for photophysics beamline at Indus-I

    International Nuclear Information System (INIS)

    Meenakshi Raja Rao, P.; Bhattacharya, S.S.; Das, N.C.; Rajasekhar, B.N.; Roy, A.P.

    1995-01-01

    Photophysics beamline makes use of a combination of two toroidal mirrors and one meter Seya-Namioka Monochromator in its fore optics. The fore optics monochromatises and steers the synchrotron radiation source (SRS) beam from its tangent point to the sample situated at a distance of about five meters. Slit widths of the monochromator are of the order of 100μ and the sample size is one mm 2 . Hence it is essential to impart precision rotational and translational movements of the same order of magnitude to the mirrors with the use of appropriate mirror mounts. Since Indus-1 operates at a pressure -9 mbar, the mirror mounts should be UHV compatible and the movements should be actuated under UHV. The mirrors along with the mirror mounts are enclosed in UHV chambers. The mirror chambers have been fabricated at Centre for Advanced Technology (CAT) workshops and tested up to a pressure of 10 -9 mbar. The mirror mounts are designed, fabricated and leak checked (He leak rate -10 std cc/s) The precision movements are achieved with the help of bellow sealed shaft mechanism and adjustable screws provided with the kinematic mount of the mirror frame. The performance of the mirror mount was tested at atmospheric pressure by using a laser beam and found to be good. The minimum displacement of the laser beam at slit and sample positions is ∼ 70μ which is quite adequate for optical alignment. The performance of the mirror mount under UHV conditions is being evaluated. (author). 4 refs., 3 figs

  6. Teaching about the Death Penalty.

    Science.gov (United States)

    Ryan, John Paul; Eden, John Michael

    1998-01-01

    Examines the reasons for the death penalty, the reasons why the death penalty attracts so much attention, whether the death penalty is applied consistently, and the evidence that the application of the death penalty may be racially biased. Provides an accompanying article on "Teaching Ideas" by Ronald A. Banaszak. (CMK)

  7. Digital Language Death

    Science.gov (United States)

    Kornai, András

    2013-01-01

    Of the approximately 7,000 languages spoken today, some 2,500 are generally considered endangered. Here we argue that this consensus figure vastly underestimates the danger of digital language death, in that less than 5% of all languages can still ascend to the digital realm. We present evidence of a massive die-off caused by the digital divide. PMID:24167559

  8. Digital language death.

    Directory of Open Access Journals (Sweden)

    András Kornai

    Full Text Available Of the approximately 7,000 languages spoken today, some 2,500 are generally considered endangered. Here we argue that this consensus figure vastly underestimates the danger of digital language death, in that less than 5% of all languages can still ascend to the digital realm. We present evidence of a massive die-off caused by the digital divide.

  9. Death Penalty in America.

    Science.gov (United States)

    Clifford, Amie L.

    1997-01-01

    Examines the legal and moral issues, controversies, and unique trial procedures involved with the death penalty. Discusses the 1972 landmark Supreme Court decision that resulted in many states abolishing this punishment, only to reintroduce it later with different provisions. Reviews the controversial case of Sam Sheppard. (MJP)

  10. The Death Penalty.

    Science.gov (United States)

    Crockett, Mark

    1990-01-01

    Provides a lesson plan on the Eighth Amendment to the U.S. Constitution and the imposition of the death penalty. Focuses on the controversy concerning capital punishment and stimulates critical thinking in an analysis and discussion of eight hypothetical situations. Includes suggestions for readings, videotapes, and writing assignments. (NL)

  11. Optimal Aging and Death

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Strulik, Holger

    2010-01-01

    This study introduces physiological aging into a simple model of optimal intertemporal consumption. In this endeavor we draw on the natural science literature on aging. According to the purposed theory, the speed of the aging process and the time of death are endogenously determined by optimal...

  12. Optimal Aging and Death

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan; Strulik, Holger

    the representative consumer is subject to physiological aging. In modeling aging we draw on recent research in the fields of biology and medicine. The speed of the aging process, and thus the time of death, are endogenously determined by optimal health investments. We calibrate the model to US data and proceed...

  13. Preventing the White Death

    DEFF Research Database (Denmark)

    Hansen, Casper Worm; Jensen, Peter S.; Madsen, Peter

    2017-01-01

    Tuberculosis (TB) is a leading cause of death worldwide and, while treatable by antibiotics since the 1940s, drug resistant strains have emerged. This paper estimates the effects of the establishment of a pre-antibiotic era public health institution, known as a TB dispensary, designed to prevent...

  14. Disparities in death

    DEFF Research Database (Denmark)

    Molitoris, Joseph John

    2017-01-01

    and accidents, (5) perinatal causes, and (6) unspecified causes. RESULTS The results show that class differentials in nearly all causes of death converged during the demographic transition. The only exception to this was the airborne infectious disease category, for which the gap between white collar...

  15. The Death of Shankar

    DEFF Research Database (Denmark)

    Seeberg, Jens

    2013-01-01

    ) in Bhubaneswar, the capital city of Orissa. The chapter explores the heterogeneous and hierarchical composition of the basti and unfolds the case of the social exclusion and ultimate death of a patient with tuberculosis who belonged to the poorest section of the basti, called Pradhan sahi. The case of both...

  16. Death in Flames

    DEFF Research Database (Denmark)

    Harvig, Lise Lock; Kveiborg, Jacob; Lynnerup, Niels

    2015-01-01

    This paper presents osteoarchaeological analyses of the human skeletal material from a burnt down house in Jutland, Denmark, dated to the first century bc. We describe how the osteological analyses of this complex site were approached and illustrate how we reconstructed the death of the human...

  17. Sudden cardiac death

    DEFF Research Database (Denmark)

    Hougen, H P; Valenzuela, Antonio Jesus Sanchez; Lachica, E

    1992-01-01

    case was inconclusive. After studying the circumstances of death, the number of discrepancies were reduced to 20, so that concordance was reached in 86% of all the cases. The results show that the combination of different methods leads to a diagnosis of myocardial infarction in far more cases than...

  18. Bee deaths need analysing

    NARCIS (Netherlands)

    Boonekamp, P.M.

    2011-01-01

    Alarm bells are ringing all over the world about the death of bee populations. Although it is not known exactly how severe the decline is, it is important to take the problem seriously. The signals are alarming and the bee is important, not just for natural ecosystems but also for the pollination of

  19. [Death of Napoleon Bonaparte].

    Science.gov (United States)

    Camici, M

    2003-06-01

    The causa mortis of Napoleon Bonaparte has been vexata quaestio for a long time. The author tries to outline a picture of Napoleon from a sanitary point of view. From the report of doctor Francesco Antonmarchi who performed the autopsy, the author tries to understans the cause of death: gastric perforation due to malignant ulcer and subsequent peritonitis with pulmonary tubercolosis.

  20. KAROSHI (WORK TO DEATH

    Directory of Open Access Journals (Sweden)

    Moh. Toriqul Chaer

    2017-05-01

    Full Text Available When the tide of unemployment hit the USA and Europe, in Japan the opposite phenomenon occurs. In 2002, in Japan deaths were recorded because of excessive works. In this country, the phenomenon of death because of excessive works is called Karoshi. Karoshi is common in Japan.  It becomes deadly syndrome as a consequence of long hours works. The debate about deaths from excessive work already sticking out in Japan since the 70s. The first official case of Karoshi was reported in 1969 when a 29-year-old male worker died because of stroke. It is estimated over ten thousand workers died each year due to death by brain and stroke caused by an overload work. Karoshi often happen to male workers dominantly. The main cause of karoshi is stress due to high pressure in the work environment, and work habits of exceeding a  standard of normal working time (8 hours. In addition, their extra time to work is imbalance with and the salary they earn. In its development, the phenomenon of karoshi contributes to the term salaryman and workaholic.

  1. Simulation of personalised haemodynamics by various mounting positions of a prosthetic valve using computational fluid dynamics.

    Science.gov (United States)

    Bongert, Markus; Geller, Marius; Pennekamp, Werner; Nicolas, Volkmar

    2018-03-03

    Diseases of the cardiovascular system account for nearly 42% of all deaths in the European Union. In Germany, approximately 12,000 patients receive surgical replacement of the aortic valve due to heart valve disease alone each year. A three-dimensional (3D) numerical model based on patient-specific anatomy derived from four-dimensional (4D) magnetic resonance imaging (MRI) data was developed to investigate preoperatively the flow-induced impact of mounting positions of aortic prosthetic valves to select the best orientation for individual patients. Systematic steady-state analysis of blood flow for different rotational mounting positions of the valve is only possible using a virtual patient model. A maximum velocity of 1 m/s was used as an inlet boundary condition, because the opening angle of the valve is at its largest at this velocity. For a comparative serial examination, it is important to define the standardised general requirements to avoid impacts other than the rotated implantation of the prosthetic aortic valve. In this study, a uniform velocity profile at the inlet for the inflow of the aortic valve and the real aortic anatomy were chosen for all simulations. An iterative process, with the weighted parameters flow resistance (1), shear stress (2) and velocity (3), was necessary to determine the best rotated orientation. Blood flow was optimal at a 45° rotation from the standard implantation orientation, which will offer a supply to the coronary arteries.

  2. A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity.

    Directory of Open Access Journals (Sweden)

    Nicholas D Leigh

    Full Text Available Toll-like receptor (TLR mediated recognition of pathogen associated molecular patterns allows the immune system to rapidly respond to a pathogenic insult. The "danger context" elicited by TLR agonists allows an initially non-immunogenic antigen to become immunogenic. This ability to alter environment is highly relevant in tumor immunity, since it is inherently difficult for the immune system to recognize host-derived tumors as immunogenic. However, immune cells may have encountered certain TLR ligands associated with tumor development, yet the endogenous stimulation is typically not sufficient to induce spontaneous tumor rejection. Of special interest are TLR5 agonists, because there are no endogenous ligands that bind TLR5. CBLB502 is a pharmacologically optimized TLR5 agonist derived from Salmonella enterica flagellin. We examined the effect of CBLB502 on tumor immunity using two syngeneic lymphoma models, both of which do not express TLR5, and thus do not directly respond to CBLB502. Upon challenge with the T-cell lymphoma RMAS, CBLB502 treatment after tumor inoculation protects C57BL/6 mice from death caused by tumor growth. This protective effect is both natural killer (NK cell- and perforin-dependent. In addition, CBLB502 stimulates clearance of the B-cell lymphoma A20 in BALB/c mice in a CD8(+ T cell-dependent fashion. Analysis on the cellular level via ImageStream flow cytometry reveals that CD11b(+ and CD11c(+ cells, but neither NK nor T cells, directly respond to CBLB502 as determined by NFκB nuclear translocation. Our findings demonstrate that CBLB502 stimulates a robust antitumor response by directly activating TLR5-expressing accessory immune cells, which in turn activate cytotoxic lymphocytes.

  3. Mounting ground sections of teeth: Cyanoacrylate adhesive versus Canada balsam.

    Science.gov (United States)

    Vangala, Manogna Rl; Rudraraju, Amrutha; Subramanyam, R V

    2016-01-01

    Hard tissues can be studied by either decalcification or by preparing ground sections. Various mounting media have been tried and used for ground sections of teeth. However, there are very few studies on the use of cyanoacrylate adhesive as a mounting medium. The aim of our study was to evaluate the efficacy of cyanoacrylate adhesive (Fevikwik™) as a mounting medium for ground sections of teeth and to compare these ground sections with those mounted with Canada balsam. Ground sections were prepared from twenty extracted teeth. Each section was divided into two halves and mounted on one slide, one with cyanoacrylate adhesive (Fevikwik™) and the other with Canada balsam. Scoring for various features in the ground sections was done by two independent observers. Statistical analysis using Student's t-test (unpaired) of average scores was performed for each feature observed. No statistically significant difference was found between the two for most of the features. However, cyanoacrylate was found to be better than Canada balsam for observing striae of Retzius (P < 0.0205), enamel lamellae (P < 0.036), dentinal tubules (P < 0.0057), interglobular dentin (P < 0.0001), sclerotic dentin - transmitted light (P < 0.00001), sclerotic dentin - polarized light (P < 0.0002) and Sharpey's fibers (P < 0.0004). This initial study shows that cyanoacrylate is better than Canada balsam for observing certain features of ground sections of teeth. However, it remains to be seen whether it will be useful for studying undecalcified sections of carious teeth and for soft tissue sections.

  4. Mirror boxes and mirror mounts for photophysics beamline

    International Nuclear Information System (INIS)

    Raja Rao, P.M.; Raja Sekhar, B.N.; Das, N.C.; Khan, H.A.; Bhattacharya, S.S.; Roy, A.P.

    1996-01-01

    Photophysics beamline makes use of one metre Seya-Namioka monochromator and two toroidal mirrors in its fore optics. The first toroidal mirror (pre mirror) focuses light originating from the tangent point of the storage ring onto the entrance slit of the monochromator and second toroidal mirror (post mirror) collects light from the exit slit of the monochromator and focuses light onto the sample placed at a distance of about one metre away from the 2nd mirror. To steer light through monochromator and to focus it on the sample of 1mm x 1mm size require precision rotational and translational motion of the mirrors and this has been achieved with the help of precision mirror mounts. Since Indus-1 operates at pressures less than 10 -9 m.bar, the mirror mounts should be manipulated under similar ultra high vacuum conditions. Considering these requirements, two mirror boxes and two mirror mounts have been designed and fabricated. The coarse movements to the mirrors are imparted from outside the mirror chamber with the help of x-y tables and precision movements to the mirrors are achieved with the help of mirror mounts. The UHV compatibility and performance of the mirror mounts connected to mirror boxes under ultra high vacuum condition is evaluated. The details of the design, fabrication and performance evaluation are discussed in this report. 5 refs., 9 figs., 1 tab

  5. Multi-Mounted X-Ray Computed Tomography.

    Science.gov (United States)

    Fu, Jian; Liu, Zhenzhong; Wang, Jingzheng

    2016-01-01

    Most existing X-ray computed tomography (CT) techniques work in single-mounted mode and need to scan the inspected objects one by one. It is time-consuming and not acceptable for the inspection in a large scale. In this paper, we report a multi-mounted CT method and its first engineering implementation. It consists of a multi-mounted scanning geometry and the corresponding algebraic iterative reconstruction algorithm. This approach permits the CT rotation scanning of multiple objects simultaneously without the increase of penetration thickness and the signal crosstalk. Compared with the conventional single-mounted methods, it has the potential to improve the imaging efficiency and suppress the artifacts from the beam hardening and the scatter. This work comprises a numerical study of the method and its experimental verification using a dataset measured with a developed multi-mounted X-ray CT prototype system. We believe that this technique is of particular interest for pushing the engineering applications of X-ray CT.

  6. Disseminated cysticercosis: clinical spectrum, Toll-like receptor-4 gene polymorphisms and role of albendazole: A prospective follow-up of 60 cases with a review of 56 published cases.

    Science.gov (United States)

    Qavi, Abdul; Garg, Ravindra Kumar; Malhotra, Hardeep Singh; Jain, Amita; Kumar, Neeraj; Malhotra, Kiran Preet; Srivastava, Pradeep Kumar; Verma, Rajesh; Sharma, Praveen Kumar

    2016-09-01

    In this study, we describe clinical and imaging spectrum, and the natural course of patients with disseminated cysticercosis. How albendazole affects the course of disease has also been evaluated. We assessed the Toll-like receptor-4 gene polymorphisms, to know the reason for the apparently higher prevalence of disseminated cysticercosis in India.Sixty consecutive patients with disseminated cysticercosis were enrolled. Sixty age-and-sex-matched healthy controls were also enrolled for the purpose of genetic study. Twenty patients, who gave consent, were treated with albendazole along with corticosteroids. Forty patients did not give consent for antiparasitic therapy. Assessment for Toll-like receptor-4 gene polymorphisms (Asp299Gly and Thr399Ile genes) was done. Patients were followed for 6 months. We also performed a literature search of cases published in English language using PubMed electronic database and analyzed 56 cases thus available.There was an increased risk (6.63 fold and 4.61 fold) of disseminated cysticercosis in the presence of Asp299Gly and Thr399Ile polymorphisms in Toll-like receptor-4, respectively. The allelic frequency of Gly (11% vs. 3%, P = 0.024, odds ratio [OR] = 3.52) and Ile alleles (11% vs. 2%, P = 0.009, OR = 4.738) in disseminated cysticercosis was high. Albendazole resulted in complete disappearance of all cerebral lesions in 35% (7/20) patients and reduction in lesion load in remaining 65% (13/20) patients. No significant change in number of cysticercal lesion was noted in patients who did not receive albendazole. No major adverse reaction following antiparasitic treatment was noted. Three deaths were recorded in patients who did not receive antiparasitic treatment.Of the 56 cases reported in PubMed, 33 patients received antiparasitic treatment with follow-up data available for 31 patients. Most (24) of these patients received albendazole. A significant clinical and/or imaging improvements, on follow up, were observed in 27 patients

  7. DMPD: When signaling pathways collide: positive and negative regulation of toll-likereceptor signal transduction. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18631453 When signaling pathways collide: positive and negative regulation of toll-...uction. PubmedID 18631453 Title When signaling pathways collide: positive and neg...l) Show When signaling pathways collide: positive and negative regulation of toll-likereceptor signal transd...likereceptor signal transduction. O'Neill LA. Immunity. 2008 Jul 18;29(1):12-20. (.png) (.svg) (.html) (.csm

  8. Low-dose radiation induces drosophila innate immunity through toll pathway activation

    International Nuclear Information System (INIS)

    Seong, Ki Moon; Kim, Cha Soon; Lee, Byung-Sub; Nam, Seon Young; Yang, Kwang Hee; Kim, Ji-Young; Jin, Young-Woo; Park, Joong-Jean; Min, Kyung-Jin

    2012-01-01

    Numerous studies report that exposing certain organisms to low-dose radiation induces beneficial effects on lifespan, tumorigenesis, and immunity. By analyzing survival after bacterial infection and antimicrobial peptide gene expression in irradiated flies, we demonstrate that low-dose irradiation of Drosophila enhances innate immunity. Low-dose irradiation of flies significantly increased resistance against gram-positive and gram-negative bacterial infections, as well as expression of several antimicrobial peptide genes. Additionally, low-dose irradiation also resulted in a specific increase in expression of key proteins of the Toll signaling pathway and phosphorylated forms of p38 and N-terminal kinase (JNK). These results indicate that innate immunity is activated after low-dose irradiation through Toll signaling pathway in Drosophila. (author)

  9. Exploitation of the Toll-like receptor system in cancer: a doubled-edged sword?

    LENUS (Irish Health Repository)

    Killeen, S D

    2012-02-03

    The toll-like receptor (TLR) system constitutes a pylogenetically ancient, evolutionary conserved, archetypal pattern recognition system, which underpins pathogen recognition by and activation of the immune system. Toll-like receptor agonists have long been used as immunoadjuvants in anti cancer immunotherapy. However, TLRs are increasingly implicated in human disease pathogenesis and an expanding body of both clinical and experimental evidence suggests that the neoplastic process may subvert TLR signalling pathways to advance cancer progression. Recent discoveries in the TLR system open a multitude of potential therapeutic avenues. Extrapolation of such TLR system manipulations to a clinical oncological setting demands care to prevent potentially deleterious activation of TLR-mediated survival pathways. Thus, the TLR system is a double-edge sword, which needs to be carefully wielded in the setting of neoplastic disease.

  10. Toll-like receptor 3 blockade in rhinovirus-induced experimental asthma exacerbations

    DEFF Research Database (Denmark)

    Silkoff, Philip E; Flavin, Susan; Gordon, Robert

    2017-01-01

    BACKGROUND: Human rhinoviruses (HRVs) commonly precipitate asthma exacerbations. Toll-like receptor 3, an innate pattern recognition receptor, is triggered by HRV, driving inflammation that can worsen asthma. OBJECTIVE: We sought to evaluate an inhibitory mAb to Toll-like receptor 3, CNTO3157......, respectively, and were then inoculated with HRV-16 within 72 hours. All subjects were monitored for respiratory symptoms, lung function, and nasal viral load. The primary end point was maximal decrease in FEV1 during 10 days after inoculation. RESULTS: In asthmatic patients (n = 63) CNTO3157 provided......: In summary, CNTO3157 was ineffective in attenuating the effect of HRV-16 challenge on lung function, asthma control, and symptoms in asthmatic patients but suppressed cold symptoms in healthy subjects. Other approaches, including blockade of multiple pathways or antiviral agents, need to be sought...

  11. Effectiveness of the toll-free line for public insurance programs.

    Science.gov (United States)

    Saunders, Cynthia M

    2005-03-01

    Toll-free lines for public insurance programs are a major point of entry to inquire about information. More than 1 million Californians are eligible for public insurance programs based on income but not yet enrolled. In 2000 and 2002, a "mystery-shopper" survey was conducted to ascertain overall effectiveness and interlanguage variation for information provided in Armenian, Cantonese, English, Farsi, Hmong, Khmer, Korean, Russian, Spanish, and Vietnamese. Although the 2002 study showed statistically significant improvements from 2000, many constructs remained problematic. In 2002, for example, statistically significant interlanguage variation was identified in discussing and checking eligibility for the program. Specifically, Spanish and Armenian callers were less likely than other language callers to have eligibility checked or deemed eligible. Removing barriers to enrollment in public insurance programs often requires political solutions, but improving customer service for the toll-free line necessitates efficiency and a focus on continuous quality improvement.

  12. Toll-like receptor activation in the pathogenesis of lupus nephritis.

    Science.gov (United States)

    Lorenz, Georg; Lech, Maciej; Anders, Hans-Joachim

    2017-12-01

    The pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis is complex but no longer enigmatic. Much progress has been made to on the polygenetic origin of lupus in identifying gene variants that permit the loss of tolerance against nuclear autoantigens. Along the same line in about 50% of lupus patients additional genetic weaknesses promote immune complex glomerulonephritis and filtration barrier dysfunction. Here we briefly summarize the pathogenesis of SLE with a focus on loss of tolerance and the role of toll-like receptors in the "pseudo"-antiviral immunity concept of systemic lupus. In addition, we discuss the local role of Toll-like receptors in intrarenal inflammation and kidney remodeling. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury

    OpenAIRE

    Fang, Huang; Wang, Peng-Fei; Zhou, Yu; Wang, Yan-Chun; Yang, Qing-Wu

    2013-01-01

    Intracerebral hemorrhage (ICH) is a common type of fatal stroke, accounting for about 15% to 20% of all strokes. Hemorrhagic strokes are associated with high mortality and morbidity, and increasing evidence shows that innate immune responses and inflammatory injury play a critical role in ICH-induced neurological deficits. However, the signaling pathways involved in ICH-induced inflammatory responses remain elusive. Toll-like receptor 4 (TLR4) belongs to a large family of pattern recognition ...

  14. Function and mechanism of toll-like receptors in cerebral ischemic tolerance: from preconditioning to treatment

    OpenAIRE

    Wang, Peng-Fei; Xiong, Xiao-Yi; Chen, Jing; Wang, Yan-Chun; Duan, Wei; Yang, Qing-Wu

    2015-01-01

    Increasing evidence suggests that toll-like receptors (TLRs) play an important role in cerebral ischemia-reperfusion injury. The endogenous ligands released from ischemic neurons activate the TLR signaling pathway, resulting in the production of a large number of inflammatory cytokines, thereby causing secondary inflammation damage following cerebral ischemia. However, the preconditioning for minor cerebral ischemia or the preconditioning with TLR ligands can reduce cerebral ischemic injury b...

  15. Defining Toll Fee of Wheeling Renewable with Reference to a Gas Pipeline in Indonesia

    Science.gov (United States)

    Hakim, Amrullah

    2017-07-01

    Indonesia has a huge number of renewable energy sources (RE) however; the utilization of these is currently very low. The main challenge of power production is its alignment with consumption levels; supply should equal demand at all times. There is a strong initiative from corporations with high energy demand, compared to other sectors, to apply a renewable portfolio standard for their energy input, e.g. 15% of their energy consumption requirement must come from a renewable energy source. To support this initiative, the utilization of power wheeling will help large factories on industrial estates to source firm and steady renewables from remote sites. The wheeling renewable via PLN’s transmission line has been regulated under the Ministry Decree in 2015 however; the tariff or toll fee has not yet been defined. The potential project to apply wheeling renewable will obtain power supply from a geothermal power plant, with power demand from the scattered factories under one company. This is the concept driving the application of power wheeling in the effort to push the growth of renewable energy in Indonesia. Given that the capacity of PLN’s transmission line are normally large and less congested compared to distribution line, the wheeling renewable can accommodate the scattered factories locations which then results in the cheaper toll fee of the wheeling renewable. Defining the best toll fee is the main topic of this paper with comparison of the toll fee of the gas pipeline infrastructure in Indonesia, so that it can be applied massively to achieve COP21’s commitment.

  16. Differential expression of toll-like receptors in patients with irritable bowel syndrome.

    LENUS (Irish Health Repository)

    Brint, Elizabeth K

    2011-02-01

    The pathogenesis of irritable bowel syndrome (IBS) is poorly understood. One contributory factor may be low-grade mucosal inflammation, perhaps initiated by the microbiota. Toll-like receptors (TLRs) are a family of pathogen-recognition receptors of the innate immune system. The aim of this study was to evaluate the potential involvement of TLRs in IBS to further understand the involvement of the innate immune system in this complex disorder.

  17. Analysis of potential diverted of passenger car to the new toll road (case study: Cileunyi - Sumedang, West Java)

    Science.gov (United States)

    Prahara, Eduardi; Suangga, Made; Lutfi Ansori, Ahmad

    2017-12-01

    This study aims to determine of potential of passenger car divert from national road to on-construction Cisumdawu Toll Road. The study was conducted by traffic count survey and followed by a roadside interview survey. Stated Preference method was used in order to analyse trip forecasting value. Mode choice model of new trip mode plans (Cisumdawu Toll Road) and current intercity road for Cileunyi - Sumedang is (UJT -UJR ) = 0.1079-0.507726x 1-0.8953764x 2, while Sumedang - Cileunyi is (UJT -UJR ) = 0.0790-0.301341x 1-0.548446x 2. Multiple linear regression analysis was used to obtain the forecasting of private vehicle that diverts to the new toll road (Cisumdawu Toll Road). Trip characteristics such as trip origin and destination, types of trips, occupations, salary, and others become a motive for respondents to choose a new trip mode. Results of the new trip mode forecasting that prefer to divert to the toll road in terms of the value of cost and time for Cileunyi - Sumedang are 74.11% and 86.62% respectively, while for Sumedang - Cileunyi are 69.60% and 76.48% respectively. These results are relatively high compare to toll planning document. The impact of this results can be determined such as lower overall fuel consumption, lower pollution and more important is the maintenance cost of national road will be decrease.

  18. METHAPHYSICS OF DEATH PENALTY

    Directory of Open Access Journals (Sweden)

    V. E. Gromov

    2017-06-01

    Full Text Available Purpose. The paper studies the problem of death penalty justifiableness in terms of democratic society from the metaphysical viewpoint. Philosophical argumentation to justify death penalty is proposed as opposed to the common idea of inhuman and uncivilized nature of court practice of sentencing to death. The essence of the study is not to rehabilitate law-based murder but to explain dialectic relation of the degrees of moral responsibility of criminals and society nourishing evildoers. The author believes that refusal from death penalty under the pretence of rule of humanism is just a liberal façade, plausible excuse for defective moral state of the society which, rejecting its own guiltiness share as for current disregards of the law, does not grow but downgrades proper human dignity. Methodology. The author applies an approach of dialectic reflection being guided by the perception of unity, relativeness and complementarity of evil and good striving to determine efficient way of resolving their contradictions in the context of moral progress of the society. Originality. Proposing philosophic approach to a death penalty problem instead of legal one, the author is not going to discuss the role of horrification, control or cruelty of the measure of restraint; moreover, he does not consider the issue of its efficiency or inefficiency. The author also does not concern vexation of mind of a criminal sentenced to life imprisonment for “humanitarian” reasons. The purpose of the author is to demonstrate that aim of the punishment is to achieve justice which becomes spiritual challenge and moral recompense not only for the criminal but for the whole society. Conclusions. Crime is first of all a problem of a society; thus, criminal behaviour of certain individuals should only be considered through a prism of moral state of the whole community. Attitude to a death penalty is the problem of spirituality and its dramatic sophistication. The author

  19. On the Effects of Central Japan Expressway's Commuter Toll Discount Policy in Nagoya Area

    Institute of Scientific and Technical Information of China (English)

    YING Jiangqian; Ryosuke Ando

    2007-01-01

    Road pricing policies have two equally important objectives that have to be considered: the optimal use of the road network and the fiscal sustainability for the management of the network. The aim of this work is to examine the effects on these two objectives of a recent pricing policy implemented in Japan's expressway networks. Recently the Nippon (Japan) Expressway Companies (NEXCO, operators of Japan's nation wide expressway network) have implemented several toll discount policies for users equipped with electronic toll collectors (ETCs). One of the policies is the commuter discount policy that discounts 50% for a journey on the NEXCO expressway no longer than 100 km during the commuting peak hours. This paper examines its effect on congestion reduction in the road network of Nagoya area and its influence on the use of expressways operated by another major local public expressway company in Nagoya. The congestion easing effect of this policy is compared with a potential marginal cost pricing scheme. These observations suggest that policy coordination regarding toll levels is needed for expressway corporations and transportation authorities for improving transportation efficiency of utilization of the whole network.

  20. Toll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium.

    Directory of Open Access Journals (Sweden)

    Idir Akhouayri

    2011-10-01

    Full Text Available Barrier epithelia that are persistently exposed to microbes have evolved potent immune tools to eliminate such pathogens. If mechanisms that control Drosophila systemic responses are well-characterized, the epithelial immune responses remain poorly understood. Here, we performed a genetic dissection of the cascades activated during the immune response of the Drosophila airway epithelium i.e. trachea. We present evidence that bacteria induced-antimicrobial peptide (AMP production in the trachea is controlled by two signalling cascades. AMP gene transcription is activated by the inducible IMD pathway that acts non-cell autonomously in trachea. This IMD-dependent AMP activation is antagonized by a constitutively active signalling module involving the receptor Toll-8/Tollo, the ligand Spätzle2/DNT1 and Ect-4, the Drosophila ortholog of the human Sterile alpha and HEAT/ARMadillo motif (SARM. Our data show that, in addition to Toll-1 whose function is essential during the systemic immune response, Drosophila relies on another Toll family member to control the immune response in the respiratory epithelium.

  1. Electronic Toll Collection Systems and their Interoperability: The State of Art

    Energy Technology Data Exchange (ETDEWEB)

    Heras Molina, J. de la; Gomez Sanchez, J.; Vassallo Magro, J.M.

    2016-07-01

    The European Electronic Toll Service (EETS) was created in 2004 with the aim of ensuring interoperability among the existing electronic toll collection (ETC) systems in Europe. However, the lack of cooperation between groups of stakeholders has not made possible to achieve this goal ten years later. The purpose of this research is to determine the better way to achieve interoperability among the different ETC systems in Europe. Our study develops a review of the six main ETC systems available worldwide: Automatic Number Plate Recognition (ANPR), Dedicated Short-Range Communications (DSRC), Radio Frequency Identification (RFID), Satellite systems (GNSS), Tachograph, and Mobile communications tolling systems. The research also provides some insight on different emerging technologies. By focusing on different operational and strategic aspects offered by each technology, we identify their main strengths, weaknesses, opportunities and threats and makes different recommendations to improve the current framework. The research concludes that given the diversity of advantages and inconveniences offered by each system, the selection of a certain ETC technology should also take into account its potential to overcome the weaknesses in the current ETC framework. In this line, different policy recommendations are proposed to improve the present ETC strategy at the EU. (Author)

  2. GSK-3β Inhibition Attenuates LPS-Induced Death but Aggravates Radiation-Induced Death via Down-Regulation of IL-6

    Directory of Open Access Journals (Sweden)

    Bailong Li

    2013-12-01

    Full Text Available Background: Exposure of high dose ionizing radiation is lethal. Signal pathways involved in radiation biology reaction still remain illdefined. Lipopolysaccharides (LPS, the ligands of Toll-like receptor 4(TLR4, could elicit strong immune responses. Glycogen synthase kinase-3β(GSK-3β promotes the production of inflammatory molecules and cell migration. Inhibition of GSK-3β provides protection against inflammation in animal models. The aim of the study was to investigate role of GSK-3β in LPS shock and ionizing radiation. Methods: WT or IL-6-/-mice or cells were pretreated with SB216763, a GSK-3β inhibitor, and survival of the mice was determined. Cell viability was assayed by Cell Counting Kit. Apoptosis was assayed by Annexin V-PI double staining. Serum concentrations of IL-6 and TNF-α were determined by ELISA. Results: SB216763 attenuated LPS induced mice or cell death but aggravated radiation induced mice or cell death. SB216763 reduced IL-6, but not TNF-α levels in vivo. IL-6-/- mice were more resistant to LPS-induced death but less resistant to radiation-induced death than wild type mice. Conclusions: Inhibition of GSK-3β conferred resistance to LPS shock but fostered death induced by ionizing radiation. Inhibition of GSK-3β was effective by reducing IL-6.

  3. Inverse axial mounting stiffness design for lithographic projection lenses.

    Science.gov (United States)

    Wen-quan, Yuan; Hong-bo, Shang; Wei, Zhang

    2014-09-01

    In order to balance axial mounting stiffness of lithographic projection lenses and the image quality under dynamic working conditions, an easy inverse axial mounting stiffness design method is developed in this article. Imaging quality deterioration at the wafer under different axial vibration levels is analyzed. The desired image quality can be determined according to practical requirements, and axial vibrational tolerance of each lens is solved with the damped least-squares method. Based on adaptive interval adjustment, a binary search algorithm, and the finite element method, the axial mounting stiffness of each lens can be traveled in a large interval, and converges to a moderate numerical solution which makes the axial vibrational amplitude of the lens converge to its axial vibrational tolerance. Model simulation is carried out to validate the effectiveness of the method.

  4. Preparation and mounting of adult Drosophila structures in Canada balsam.

    Science.gov (United States)

    Stern, David L; Sucena, Elio

    2012-03-01

    The Drosophila cuticle carries a rich array of morphological details. Thus, cuticle examination has had a central role in the history of genetics. To prepare fine "museum-quality," permanent slides, it is best to mount specimens in Canada Balsam. It is difficult to give precise recipes for Canada Balsam, because every user seems to prefer a slightly different viscosity. Dilute solutions spread easily and do not dry too rapidly while mounting specimens. The disadvantage is that there is actually less Balsam in a "drop" of the solution, and when dried, it can contract from the sides of the coverslip, sometimes disturbing the specimen. Unfortunately, there is no substitute for experience when using Canada Balsam. This protocol describes a procedure for mounting adult cuticles in Canada Balsam.

  5. Solar rotation measurements at Mount Wilson. Pt. 2

    International Nuclear Information System (INIS)

    Labonte, B.J.; Howard, R.; Carnegie Institution of Washington, Pasadena

    1981-01-01

    Possible sources of systematic error in solar Doppler rotational velocities are examined. Scattered light is shown to affect the Mount Wilson solar rotation results, but this effect is not enough to bring the spectroscopic results in coincidence with the sunspot rotation. Interference fringes at the spectrograph focus at Mount Wilson have in two intervals affected the rotation results. It has been possible to correlate this error with temperature and thus correct for it. A misalignment between the entrance and exit slits is a possible source of error, but for the Mount Wilson slit configuration the amplitude of this effect is negligibly small. Rapid scanning of the solar image also produces no measurable effect. (orig.)

  6. Linear and/or curvilinear rail mount system

    Science.gov (United States)

    Thomas, Jackie D. (Inventor); Harris, Lawanna L. (Inventor)

    2012-01-01

    One or more linear and/or curvilinear mounting rails are coupled to a structure. Each mounting rail defines a channel and at least one cartridge assembly is engaged in the channel. Each cartridge assembly includes a housing that slides within the channel. The housing defines a curvilinearly-shaped recess longitudinally aligned with the channel when the housing is in engagement therewith. The cartridge assembly also includes a cleat fitted in the recess for sliding engagement therealong. The cleat can be coupled to a fastener that passes through the mounting rail and the housing when the housing is so-engaged in the channel. The cleat is positioned in the recess by a position of the fastener.

  7. Death from Nitrous Oxide.

    Science.gov (United States)

    Bäckström, Björn; Johansson, Bengt; Eriksson, Anders

    2015-11-01

    Nitrous oxide is an inflammable gas that gives no smell or taste. It has a history of abuse as long as its clinical use, and deaths, although rare, have been reported. We describe two cases of accidental deaths related to voluntary inhalation of nitrous oxide, both found dead with a gas mask covering the face. In an attempt to find an explanation to why the victims did not react properly to oncoming hypoxia, we performed experiments where a test person was allowed to breath in a closed system, with or without nitrous oxide added. Vital signs and gas concentrations as well as subjective symptoms were recorded. The experiments indicated that the explanation to the fact that neither of the descendents had reacted to oncoming hypoxia and hypercapnia was due to the inhalation of nitrous oxide. This study raises the question whether nitrous oxide really should be easily, commercially available. © 2015 American Academy of Forensic Sciences.

  8. [Karoshi, death by overwork].

    Science.gov (United States)

    Uehata, Tetsunojo

    2005-07-01

    Karoshi (death by overwork) is one of social medical terms, which used by survivors of victims who attacked with cardiovascular diseases such as stroke, myocardial infarction and sudden cardiac death. In Dec. 2000, Compensation Standard of cardiovascular diseases in Workers' Insurance was changed and admitted the relationship between chronic fatigue and cardiovascular attacks. As a result, compensation numbers of Karoshi attributed to three hundred and more from about 80 cases. The Ministry of Health, Labour and Welfare thinks that most of Karoshi caused by long working hours continuing for several months, especially without payment, so that the Labour Standard Inspector Office requests to decrease overtime work more than 45 hours per month to firm administrators.

  9. AN AUDIT OF MATERNAL DEATHS

    Directory of Open Access Journals (Sweden)

    Basavana Gowda

    2015-03-01

    Full Text Available OBJECTIVES: A study of maternal death conducted to evaluate various factors responsible for maternal deaths. To identify complications in pregnancy, a childbirth which result in maternal death, and to identify opportunities for preventive intervention and understand the events leading to death; so that improving maternal health and reducing maternal mortality rate significantly. To analyze the causes and epidemiological amounts maternal mortality e.g. age parity, socioeconomic status and literacy. In order to reduce maternal mortality and to implement safe motherhood program and complications of pregnancy and to find out safe motherhood program. METHODS: The data collected was a retrograde by a proforma containing particulars of the diseased, detailed history and relatives were interviewed for additional information. The data collected was analysed. RESULTS: Maternal mortality rate in our own institution is 200/ 100,000 live births. Among 30 maternal deaths, 56% deaths (17 were among low socio - economic status, groups 60% deaths among unbooked 53.5% deaths more along illiterates evidenced by direct and indirect deaths about 25% of deaths were preventable. CONCLUSION: Maternal death is a great tragedy in the family life. It is crusade to know not just the medical cause of the death but the circumstances what makes these continued tragic death even more unacceptable is that deaths are largely preventable

  10. Square Van Atta reflector with conducting mounting flame

    DEFF Research Database (Denmark)

    Nielsen, Erik Dragø

    1970-01-01

    A theoretical and numerical analysis of square Van Atta reflectors has been carried out with or without a conducting plate, used for mounting of the antenna elements. The Van Atta reflector investigated has antenna elements which are parallel half-wave dipoles interconnected in pairs by transmiss......A theoretical and numerical analysis of square Van Atta reflectors has been carried out with or without a conducting plate, used for mounting of the antenna elements. The Van Atta reflector investigated has antenna elements which are parallel half-wave dipoles interconnected in pairs...

  11. Experimental study of some mounting brackets to support fuel elements

    International Nuclear Information System (INIS)

    Aubert, M.; Poglia, S.; Roche, R.

    1958-09-01

    In an atomic pile with vertical channels, fuel elements are stacked on one another. According to a possible assembly, fuel element can be contained by a graphite sleeve and be supported by a mounting bracket in this sleeve. Sleeves are then stacked on one another. The authors report the investigation of different designs for these mounting brackets. They describe their mechanical role and their mechanical, aerodynamic, neutronic and test conditions. They report tests performed on brackets made in graphite and on brackets made in stainless steel and graphite, and discuss the obtained results

  12. Geology of the Ugashik-Mount Peulik Volcanic Center, Alaska

    Science.gov (United States)

    Miller, Thomas P.

    2004-01-01

    The Ugashik-Mount Peulik volcanic center, 550 km southwest of Anchorage on the Alaska Peninsula, consists of the late Quaternary 5-km-wide Ugashik caldera and the stratovolcano Mount Peulik built on the north flank of Ugashik. The center has been the site of explosive volcanism including a caldera-forming eruption and post-caldera dome-destructive activity. Mount Peulik has been formed entirely in Holocene time and erupted in 1814 and 1845. A large lava dome occupies the summit crater, which is breached to the west. A smaller dome is perched high on the southeast flank of the cone. Pyroclastic-flow deposits form aprons below both domes. One or more sector-collapse events occurred early in the formation of Mount Peulik volcano resulting in a large area of debris-avalanche deposits on the volcano's northwest flank. The Ugashik-Mount Peulik center is a calcalkaline suite of basalt, andesite, dacite, and rhyolite, ranging in SiO2 content from 51 to 72 percent. The Ugashik-Mount Peulik magmas appear to be co-genetic in a broad sense and their compositional variation has probably resulted from a combination of fractional crystallization and magma-mixing. The most likely scenario for a future eruption is that one or more of the summit domes on Mount Peulik are destroyed as new magma rises to the surface. Debris avalanches and pyroclastic flows may then move down the west and, less likely, east flanks of the volcano for distances of 10 km or more. A new lava dome or series of domes would be expected to form either during or within some few years after the explosive disruption of the previous dome. This cycle of dome disruption, pyroclastic flow generation, and new dome formation could be repeated several times in a single eruption. The volcano poses little direct threat to human population as the area is sparsely populated. The most serious hazard is the effect of airborne volcanic ash on aircraft since Mount Peulik sits astride heavily traveled air routes connecting the U

  13. Mount Sinai Hospital's approach to Ontario's Health System Funding Reform.

    Science.gov (United States)

    Chalk, Tyler; Lau, Davina; Morgan, Matthew; Dietrich, Sandra; Beduz, Mary Agnes; Bell, Chaim M

    2014-01-01

    In April 2012, the Ontario government introduced Health System Funding Reform (HSFR), a transformational shift in how hospitals are funded. Mount Sinai Hospital recognized that moving from global funding to a "patient-based" model would have substantial operational and clinical implications. Adjusting to the new funding environment was set as a top corporate priority, serving as the strategic basis for re-examining and redesigning operations to further improve both quality and efficiency. Two years into HSFR, this article outlines Mount Sinai Hospital's approach and highlights key lessons learned. Copyright © 2014 Longwoods Publishing.

  14. MRI of 'brain death'

    International Nuclear Information System (INIS)

    Nishino, Shigeki; Itoh, Takahiko; Tuchida, Shohei; Kinugasa, Kazushi; Asari, Shoji; Nishimoto, Akira; Sanou, Kazuo.

    1990-01-01

    Magnetic resonance imaging (MRI) was undertaken for two patients who suffered from severe cerebrovascular diseases and were clinically brain dead. The MRI system we used was Resona (Yokogawa Medical Systems, superconductive system 0.5 T) and the CT apparatus was Toshiba TCT-300. Initial CT and MRI were undertaken as soon as possible after admission, and repeated sequentially. After diagnosis of brain death, we performed angiography to determine cerebral circulatory arrest, and MRI obtained at the same time was compared with the angiogram and CT. Case 1 was a 77-year-old man who was admitted in an unconscious state. CT and MRI on the second day after hospitalization revealed cerebellar infarction. He was diagnosed as brain dead on day 4. Case 2 was a 35-year-old man. When he was transferred to our hospital, he was in cardiorespiratory arrested. Cardiac resuscitation was successful but no spontaneous respiration appeared. CT and MRI on admission revealed right intracerebral hemorrhage. Angiography revealed cessation of contrast medium in intracranial vessels in both of the patients. We found no 'flow signal void sign' in the bilateral internal carotid and basilar arteries on MRI images in both cases after brain death. MRI, showing us the anatomical changes of the brain, clearly revealed brain herniations, even though only nuclear findings of 'brain tamponade' were seen on CT. But in Case 1, we could not see the infarct lesions in the cerebellum on MR images obtained after brain death. This phenomenon was caused by the whole brain ischemia masking the initial ischemic lesions. We concluded that MRI was useful not only the anatomical display of lesions and brain herniation with high contrast resolution but for obtaining information on cerebral circulation of brain death. (author)

  15. [Sudden death from hypoglycemia].

    Science.gov (United States)

    Asmundo, A; Aragona, M; Gualniera, P; Aragona, F

    1995-12-01

    The sudden death by hypoglycemia is an aspect of the forensic pathology frequently neglected. Authors initially described the pathogenesis of different hypoglycemia forms, distinguishing the primary ones due to hyperinsulinism and the secondary ones due to functional insufficiency of other organs (hypophysis, thyroid, adrenal gland, liver); after that Authors described three cases of sudden death induced hypoglycemia by hyperinsulinism: two were unweaned with nesidioblastosis and one adolescent. In any form of hypoglycemia the central nervous system damage is present with evident neuronal degenerative-necrotic phenomena, widespread edema with microhemorrhage, swollen and dissociation of myelin sheath, glial cells hyperplasia. Death caused by primary hypoglycemia is histopathologically different from the secondary one because of the maintenance of hepatic glycogen content in the former, that increase in striated muscles, including the heart, in spite of the constant secretion of catecholamine from the adrenal medulla. Glycogen is depleted in secondary hypoglycemia. In the primary form, behind the adrenal medulla hyperfunction, the increased functional activity of the adrenal cortex is moderate, contrasting with the seriousness of the syndrome, due prevalently to inhibit the gluconeogenesis response conditioned by the persistence of stored glycogen in the liver, heart and striated muscles. The rare anoxic processes coming with resynthesis of hepatic glycogen have to be considered in the differential diagnosis. The primary hypoglycemic death, especially in unweaned, is frequently promoted by other processes inducing hypoxia (fetal asphyxia outcome, pneumonia, etc.) or worsening the hypoglycemia (hypothyroidism, etc.). The secondary hypoglycemias are characterized by the normality of exocrine pancreas and by organic alterations that cause glycogen depletion from the liver.

  16. Death and digital photography

    Directory of Open Access Journals (Sweden)

    Ennis, Helen

    2011-01-01

    Full Text Available This essay considers new possibilities for photographing the dying and dead in Australia that have been enabled by digital technologies. It argues that vernacular digital photographs demonstrate unprecedented degrees of control and privacy and further that they are purposefully withheld from public view, thus raising issues about visibility and secrecy.Some historical context is provided. Post mortem photographs were not uncommon in the nineteenth century but were in the domain of professional studio photographers. Commissioning post mortem portraits was rare for most of the twentieth century, due to changing attitudes to death and the transformation of the photographic industry. Photographing the deceased re-emerged in the 1980s, notably in the area of neonatal death.In the last five years death-related vernacular photographs have begun to proliferate. Unlike analogue processes, digital photography bypasses the involvement of others in processing and printing private images. Distribution to intimates can be achieved instantaneously via the internet, reinforcing social and familial connections.Vernacular digital photographs of the deceased do not address historical tradition but share their domestic and intimate contexts. Nor do they belong to a unified group, yet they have a common vocabulary which emphasises specificity and detail.

  17. Death and Digital Photography

    Directory of Open Access Journals (Sweden)

    Helen Ennis

    2011-03-01

    Full Text Available This essay considers new possibilities for photographing the dying and dead in Australia that have been enabled by digital technologies. It argues that vernacular digital photographs demonstrate unprecedented degrees of control and privacy and further that they are purposefully withheld from public view, thus raising issues about visibility and secrecy. Some historical context is provided. Post mortem photographs were not uncommon in the nineteenth century but were in the domain of professional studio photographers. Commissioning post mortem portraits was rare for most of the twentieth century, due to changing attitudes to death and the transformation of the photographic industry. Photographing the deceased re-emerged in the 1980s, notably in the area of neonatal death. In the last five years death-related vernacular photographs have begun to proliferate. Unlike analogue processes, digital photography bypasses the involvement of others in processing and printing private images. Distribution to intimates can be achieved instantaneously via the internet, reinforcing social and familial connections. Vernacular digital photographs of the deceased do not address historical tradition but share their domestic and intimate contexts. Nor do they belong to a unified group, yet they have a common vocabulary which emphasises specificity and detail.

  18. Fear of death.

    Science.gov (United States)

    Penson, Richard T; Partridge, Rosamund A; Shah, Muhammad A; Giansiracusa, David; Chabner, Bruce A; Lynch, Thomas J

    2005-02-01

    Shortly before his death in 1995, Kenneth B. Schwartz, a cancer patient at Massachusetts General Hospital (MGH) founded The Kenneth B. Schwartz Center at MGH. The Schwartz Center is a nonprofit organization dedicated to supporting and advancing compassionate health care delivery, which provides hope to the patient and support to caregivers and encourages the healing process. The center sponsors the Schwartz Center Rounds, a monthly multidisciplinary forum where caregivers reflect on important psychosocial issues faced by patients, their families, and their caregivers, and gain insight and support from fellow staff members. For many, cancer is synonymous with death. Fearing death is a rational response. For too long, medicine has ignored this primeval fear. Increasingly, clinicians recognize and address end-of-life issues, facing patients' and our own emotional vulnerabilities in order to connect and explore problems and fears. Listening and learning from the patient guides us as we acknowledge much of the mystery that still surrounds the dying process. Rarely is there a simple or right answer. An empathetic response to suffering patients is the best support. Support is vital in fostering the adjustment of patients. A silent presence may prove more helpful than well-meant counsel for many patients. Through an examination of eight caregiver narratives of their patients' experiences, the role of the health care provider in the dying process, particularly in regard to challenging fear, is reviewed.

  19. [Does the mounting of gastrointestinal biopsies on millipore filter contribute to an improved section quality?

    DEFF Research Database (Denmark)

    Asmussen, L.; Bernstein, I.; Matzen, P.

    2009-01-01

    orientation, GIB is occasionally mounted on millipore filter (MF) in an attempt to place the deep cut side onto the MF. The importance of this technique for section quality is evaluated in this study. MATERIAL AND METHOD: The material comprised three consecutive series of GIB (60 gastric, duodenal......, and colorectal GIB, respectively). Sections were grouped in MF-mounted versus non-mounted GIB, the proportion of fully acceptable sections among mounted versus non-mounted GIB was recorded. RESULTS: 77.2% of all GIBs were MF-mounted. 33.1% of mounted GIBs versus 48.8% of non-mounted GIBs were assessed as fully...... acceptable sections. The differences between these figures are not statistically significant. 41.7% of the mounted GIBs were placed with the mucosal surface facing the MF, which entails a risk of damaging the tissue. CONCLUSION: MF-mounting of GIB did not contribute to section quality. Since the handling...

  20. A Death in the Family: Death as a Zen Concept

    Science.gov (United States)

    Black, Helen K.; Rubinstein, Robert L.

    2013-01-01

    This study is based on original research that explored family reaction to the death of an elderly husband and father. We interviewed 34 families (a family included a widow and two adult biological children) approximately 6 to 10 months after the death. In one-on-one interviews, we discussed family members' initial reaction to the death, how the…

  1. DMPD: The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17449723 The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. Sh...Show The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. PubmedID 17449723 Title The Tro...ll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. Authors Sheedy F

  2. seasonal population dynamics of rodents of mount chilalo, arsi ...

    African Journals Online (AJOL)

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    ABSTRACT: A study on seasonal population dynamics of rodents was carried out on Mount. Chilalo from .... vegetation growth, availability of food and water, and ... vegetation (3,300–4,200 masl) (Alemayehu. Mengistu, 1975; APEDO and ABRDP, 2004). The mountain is one of the Afrotropical biodiversity hotspots areas.

  3. Vegetation types on Mount Akiki, Northern Luzon, Philippines

    NARCIS (Netherlands)

    Bout, I.E.

    2002-01-01

    Mount Akiki (16° 37’ N, 120° 53’ E, c. 2760 m alt.) is one of the highest mountain peaks in the Cordillera mountain range, Luzon Island, Philippines. It is situated in the municipality of Benguet, north-east of Baguio City (a world famous tourist city in the region) and is north-west of Mt Pulog,

  4. Kuidas koostada meeskonda - Mount Everesti ainetel / Marii Karell

    Index Scriptorium Estoniae

    Karell, Marii, 1980-

    2003-01-01

    Eesti meeskonna Mount Everesti tippu juhtinud Tõivo Sarmet selgitab toimunud ekspeditsiooni näitel, miks tema peab meeskonna komplekteerimisel oluliseimaks inimeste iseloomuomadusi. Ekstreemoludes hakkama saamiseks tuleb meeles pidada, et eesmärk on ühine ja kellegi ego ei tohi seda nurjata, rõhutab Sarmet. Kommenteerib Alar Sikk

  5. Nozzle Mounting Method Optimization Based on Robot Kinematic Analysis

    Science.gov (United States)

    Chen, Chaoyue; Liao, Hanlin; Montavon, Ghislain; Deng, Sihao

    2016-08-01

    Nowadays, the application of industrial robots in thermal spray is gaining more and more importance. A desired coating quality depends on factors such as a balanced robot performance, a uniform scanning trajectory and stable parameters (e.g. nozzle speed, scanning step, spray angle, standoff distance). These factors also affect the mass and heat transfer as well as the coating formation. Thus, the kinematic optimization of all these aspects plays a key role in order to obtain an optimal coating quality. In this study, the robot performance was optimized from the aspect of nozzle mounting on the robot. An optimized nozzle mounting for a type F4 nozzle was designed, based on the conventional mounting method from the point of view of robot kinematics validated on a virtual robot. Robot kinematic parameters were obtained from the simulation by offline programming software and analyzed by statistical methods. The energy consumptions of different nozzle mounting methods were also compared. The results showed that it was possible to reasonably assign the amount of robot motion to each axis during the process, so achieving a constant nozzle speed. Thus, it is possible optimize robot performance and to economize robot energy.

  6. Parallax error in the monocular head-mounted eye trackers

    DEFF Research Database (Denmark)

    Mardanbeigi, Diako; Witzner Hansen, Dan

    2012-01-01

    each parameter affects the error. The optimum distribution of the error (magnitude and direction) in the field of view varies for different applications. However, the results can be used for finding the optimum parameters that are needed for designing a head-mounted gaze tracker. It has been shown...

  7. Polynomial modal analysis of lamellar diffraction gratings in conical mounting.

    Science.gov (United States)

    Randriamihaja, Manjakavola Honore; Granet, Gérard; Edee, Kofi; Raniriharinosy, Karyl

    2016-09-01

    An efficient numerical modal method for modeling a lamellar grating in conical mounting is presented. Within each region of the grating, the electromagnetic field is expanded onto Legendre polynomials, which allows us to enforce in an exact manner the boundary conditions that determine the eigensolutions. Our code is successfully validated by comparison with results obtained with the analytical modal method.

  8. Evaluation of HOPG mounting possibilities for multiplexing spectrometers

    DEFF Research Database (Denmark)

    Groitl, Felix; Bartkowiak, Marek; Bergmann, Ryan M.

    2017-01-01

    Four different methods for mounting HOPG analyzer crystals on Si holders have been evaluated in the design process of the new multiplexing spectrometer CAMEA. Contrary to neutron optics used in standard spectrometers, the new instrument concept employs a series of analyzer segments behind each...

  9. Design of the GOES Telescope secondary mirror mounting

    Science.gov (United States)

    Hookman, Robert A.

    1989-01-01

    The GOES Telescope utilizes a flexure mounting system for the secondary mirror to minimize thermally induced distortions of the secondary mirror. The detailed design is presented along with a discussion of the microradian pointing requirements and how they were achieved. The methodology used to dynamically tune the flexure/secondary mirror assembly to minimize structural interactions will also be discussed.

  10. Adjustable bipod flexures for mounting mirrors in a space telescope.

    Science.gov (United States)

    Kihm, Hagyong; Yang, Ho-Soon; Moon, Il Kweon; Yeon, Jeong-Heum; Lee, Seung-Hoon; Lee, Yun-Woo

    2012-11-10

    A new mirror mounting technique applicable to the primary mirror in a space telescope is presented. This mounting technique replaces conventional bipod flexures with flexures having mechanical shims so that adjustments can be made to counter the effects of gravitational distortion of the mirror surface while being tested in the horizontal position. Astigmatic aberration due to the gravitational changes is effectively reduced by adjusting the shim thickness, and the relation between the astigmatism and the shim thickness is investigated. We tested the mirror interferometrically at the center of curvature using a null lens. Then we repeated the test after rotating the mirror about its optical axis by 180° in the horizontal setup, and searched for the minimum system error. With the proposed flexure mount, the gravitational stress at the adhesive coupling between the mirror and the mount is reduced by half that of a conventional bipod flexure for better mechanical safety under launch loads. Analytical results using finite element methods are compared with experimental results from the optical interferometer. Vibration tests verified the mechanical safety and optical stability, and qualified their use in space applications.

  11. Vertically mounted bifacial photovoltaic modules: A global analysis

    International Nuclear Information System (INIS)

    Guo, Siyu; Walsh, Timothy Michael; Peters, Marius

    2013-01-01

    Bifacial PV (photovoltaic) modules have recently come to increasing attention and various system designs have been investigated. In this paper, a global comparison is made between vertically mounted bifacial modules facing East–West and conventionally mounted mono-facial modules. An analytical method is used to calculate the radiation received by these two module configurations. It is found that the answer to the question which of these two module configurations performs better strongly depends on three factors: (i) the latitude, (ii) the local diffuse fraction and (iii) the albedo. In a subsequent part of the paper, the minimum albedo required to result in a better performance for vertically mounted bifacial modules is calculated for every place in the world. The calculation is based on measured data of the diffuse light fraction and the results are shown in the form of a global map. Finally, the albedo requirements are compared with the measured global albedo distribution. The calculation allows a distinct decision which module configuration is more suitable for a certain place in the world. The result is also shown as a map defining the corresponding areas. - Highlights: • Vertically mounted bifacial module and conventionally monofacial module are compared. • The key factors affecting the performance of the two configurations are investigated. • Which module configuration is more suitable for each place is shown in a world map. • The minimum albedo for bifacial modules to have a better performance is calculated

  12. Birds of Mount Kisingiri, Nyanza Province, including a preliminary ...

    African Journals Online (AJOL)

    Mount Kisingiri comprises a much overlooked highland massif in southern Nyanza. Province with a hitherto ..... This imbalance in relative species abundance within a defined ecological niche could .... Hills is unsuitable for foraging or breeding but there is extensive savanna grassland and suitable ..... Columba guinea nf.

  13. Biogeographic patterns of forest diversity at mount Kasigau, Kenya ...

    African Journals Online (AJOL)

    The study reports 140 species, 46 were measured in only one plot, and affinities for 75 species to the Somalia-Masai (43%), Afromontane (29%), and Zanzibar- Inhambane (Coastal, 28%) floristic regions. Cluster and Indicator Species Analyses identified eight community types. Mount Kasigau uniquely conserves much ...

  14. Light Field Rendering for Head Mounted Displays using Pixel Reprojection

    DEFF Research Database (Denmark)

    Hansen, Anne Juhler; Klein, Jákup; Kraus, Martin

    2017-01-01

    Light field displays have advantages over traditional stereoscopic head mounted displays, for example, because they can overcome the vergence-accommodation conflict. However, rendering light fields can be a heavy task for computers due to the number of images that have to be rendered. Since much ...

  15. Improved resolution by mounting of tissue sections for laser microdissection.

    NARCIS (Netherlands)

    Dijk, M.C.R.F. van; Rombout, P.D.M.; Dijkman, H.B.P.M.; Ruiter, D.J.; Bernsen, M.R.

    2003-01-01

    BACKGROUND: Laser microbeam microdissection has greatly facilitated the procurement of specific cell populations from tissue sections. However, the fact that a coverslip is not used means that the morphology of the tissue sections is often poor. AIMS: To develop a mounting method that greatly

  16. Rollin' in Style!: Students Design Bike Mounted Skateboard Racks

    Science.gov (United States)

    Massey, Rick

    2008-01-01

    Recognizing the increasing popularity of skateboarding, the author has found a project that teaches design and manufacturing concepts--and, of equal importance, really gets his students motivated. He challenges them to design and build a skateboard rack that mounts easily on a bicycle. The project benefits students by teaching creativity, the…

  17. The mount Cameroon height determined from ground gravity data ...

    African Journals Online (AJOL)

    Abstract This paper deals with the accurate determination of mount Cameroon orthometric height, by combining ground gravity data, global navigation satellite system (GNSS) observations and global geopotential models. The elevation of the highest point (Fako) is computed above the WGS84 reference ellipsoid.

  18. Volcano ecology: flourishing on the flanks of Mount St. Helens

    Science.gov (United States)

    Rhonda Mazza; Charlie Crisafulli

    2016-01-01

    Mount St. Helens’ explosive eruption on May 18, 1980, was a pivotal moment in the field of disturbance ecology. The subsequent sustained, integrated research effort has shaped the development of volcano ecology, an emerging field of focused research. Excessive heat, burial, and impact force are some of the disturbance mechanisms following an eruption. They are also...

  19. Mount St. Helens 30 years later: a landscape reconfigured.

    Science.gov (United States)

    Rhonda Mazza

    2010-01-01

    On May 18, 1980, after two months of tremors, Mount St. Helens erupted spectacularly and profoundly changed a vast area surrounding the volcano. The north slope of the mountain catastrophically failed, forming the largest landslide witnessed in modern times. The largest lobe of this debris avalanche raced 14 miles down the Toutle River...

  20. Mount St. Helens: Still erupting lessons 31 years later

    Science.gov (United States)

    Rhonda Mazza; Charlie Crisafulli; Fred Swanson

    2011-01-01

    The massive volcanic eruption of Mount St. Helens 31 years ago provided the perfect backdrop for studying the earliest stages of forest development. Immediately after the eruption, some areas of the blast area were devoid of life. On other parts of the volcanic landscape, many species survived, although their numbers were greatly reduced. Reassembly began at many...

  1. Assessing climate change impacts on water balance in the Mount

    Indian Academy of Sciences (India)

    A statistical downscaling known for producing station-scale climate information from GCM output was preferred to evaluate the impacts of climate change within the Mount Makiling forest watershed, Philippines. The lumped hydrologic BROOK90 model was utilized for the water balance assessment of climate change ...

  2. Ethnobotanical survey of \\'wild\\' woody plant resources at Mount ...

    African Journals Online (AJOL)

    This paper focuses on the naming and use of plants by Taita who live at Mount Kasigau in Kenya's Eastern Arc Mountains. Plant vouchers and ethnobotanical data were compiled from transects and within 55 ecological plots, and during participant observations, home surveys, and semi-structured interviews with residents.

  3. Forest Carbon Stocks in Woody Plants of Mount Zequalla Monastery ...

    African Journals Online (AJOL)

    Carbon sequestration through forestry has the potential to play a significant role in ameliorating global environmental problems such as atmospheric accumulation of GHG's and climate change.The present study was undertaken to estimate forest carbon stock along altitudinal gradient in Mount Zequalla Monastery forest.

  4. Astrophotography on the go using short exposures with light mounts

    CERN Document Server

    Ashley, Joseph

    2015-01-01

    No longer are heavy, sturdy, expensive mounts and tripods required to photograph deep space. With today's advances in technology, all that is required is an entry-DSLR and an entry level GoTo telescope. Here is all of the information needed to start photographing the night sky without buying expensive tracking mounts. By using multiple short exposures and combining them with mostly ‘freeware’ computer programs, the effect of image rotation can be minimized to a point where it is undetectable in normal astrophotography, even for a deep-sky object such as a galaxy or nebula. All the processes, techniques, and equipment needed to use inexpensive, lightweight altazimuth and equatorial mounts and very short exposures photography to image deep space objects are explained, step-by-step, in full detail, supported by clear, easy to understand graphics and photographs.   Currently available lightweight mounts and tripods are identified and examined from an economic versus capability perspective to help users deter...

  5. 25 years of ecological change at Mount St. Helens.

    Science.gov (United States)

    V.H. Dale; C.M. Crisafulli; F.J. Swanson

    2005-01-01

    18 May 2005 marks the 25th anniversary of the massive eruption of Mount St. Helens. This eruption involved diverse geological processes (1) that disturbed forests, meadows, lakes, an drivers (2) (see the figure). A huge landslide and searing flows of hot gases and pumic framents (pyroclastic flows) inundated 60 km2 of land, obliterating...

  6. Geologic Map of Mount Mazama and Crater Lake Caldera, Oregon

    Science.gov (United States)

    Bacon, Charles R.

    2008-01-01

    Crater Lake partly fills one of the most spectacular calderas of the world, an 8-by-10-km basin more than 1 km deep formed by collapse of the volcano known as Mount Mazama (fig. 1) during a rapid series of explosive eruptions about 7,700 years ago. Having a maximum depth of 594 m, Crater Lake is the deepest lake in the United States. Crater Lake National Park, dedicated in 1902, encompasses 645 km2 of pristine forested and alpine terrain, including the lake itself, virtually all of Mount Mazama, and most of the area of the geologic map. The geology of the area was first described in detail by Diller and Patton (1902) and later by Williams (1942), whose vivid account led to international recognition of Crater Lake as the classic collapse caldera. Because of excellent preservation and access, Mount Mazama, Crater Lake caldera, and the deposits formed by the climactic eruption constitute a natural laboratory for study of volcanic and magmatic processes. For example, the climactic ejecta are renowned among volcanologists as evidence for systematic compositional zonation within a subterranean magma chamber. Mount Mazama's climactic eruption also is important as the source of the widespread Mazama ash, a useful Holocene stratigraphic marker throughout the Pacific Northwest, adjacent Canada, and offshore. A detailed bathymetric survey of the floor of Crater Lake in 2000 (Bacon and others, 2002) provides a unique record of postcaldera eruptions, the interplay between volcanism and filling of the lake, and sediment transport within this closed basin. Knowledge of the geology and eruptive history of the Mount Mazama edifice, greatly enhanced by the caldera wall exposures, gives exceptional insight into how large volcanoes of magmatic arcs grow and evolve. Lastly, the many smaller volcanoes of the High Cascades beyond the limits of Mount Mazama are a source of information on the flux of mantle-derived magma through the region. General principles of magmatic and eruptive

  7. On social death: ostracism and the accessibility of death thoughts.

    Science.gov (United States)

    Steele, Caroline; Kidd, David C; Castano, Emanuele

    2015-01-01

    Being rejected, excluded, or simply ignored is a painful experience. Ostracism researchers have shown its powerful negative consequences (Williams, 2007), and sociologists have referred to such experiences as social death (Bauman, 1992). Is this is just a metaphor or does being ostracized make death more salient in people's minds? An experiment was conducted in which participants experienced ostracism or inclusion using the Cyberball manipulation, and the accessibility of death-related thoughts was measured via a word-stem completion puzzle. Results showed enhanced death-thought accessibility in the ostracism condition, as well as a negative effect of dispositional self-esteem on the accessibility of death-related thoughts.

  8. Exploring Virtual Worlds With Head-Mounted Displays

    Science.gov (United States)

    Chung, James C.; Harris, Mark R.; Brooks, Frederick P.; Fuchs, Henry; Kelley, Michael T.; Hughes, John W.; Ouh-Young, Ming; Cheung, Clement; Holloway, Richard L.; Pique, Michael

    1989-09-01

    For nearly a decade the University of North Carolina at Chapel Hill has been conducting research in the use of simple head-mounted displays in "real-world" applications. Such units provide the user with non-holographic true three-dimensional information, since the kinetic depth effect, stereoscopy, and other visual cues combine to immerse the user in a "virtual world" which behaves like the real world in some respects. UNC's head-mounted display was built inexpensively from commercially available off-the-shelf components. Tracking of the the user's head position and orientation is performed by a Polhemus Navigation Sciences' 3SPACE* tracker. The host computer uses the tracking information to generate updated images corresponding to the user's new left eye and right eye views. The images are broadcast to two liquid crystal television screens (220x320 pixels) mounted on a horizontal shelf at the user's forehead. The user views these color screens through half-silvered mirrors, enabling the computer-generated image to be superimposed upon the user's real physical environment. The head-mounted display has been incorporated into existing molecular modeling and architectural applications being developed at UNC. In molecular structure studies, chemists are presented with a room-sized molecule with which they can interact in a manner more intuitive than that provided by conventional two-dimensional displays and dial boxes. Walking around and through the large molecule may provide quicker understanding of its structure, and such problems as drug-enzyme docking may be approached with greater insight. In architecture, the head-mounted display enables clients to better appreciate three-dimensional designs, which may be misinterpreted in their conventional two-dimensional form by untrained eyes. The addition of a treadmill to the system provides additional kinesthetic input into the understanding of building size and scale.

  9. RIPPED TO DEATH

    OpenAIRE

    Weinlich, Ricardo; Dillon, Christopher P; Green, Douglas R

    2011-01-01

    An old puzzle in the field of cell death was recently solved: the mysterious embryonic lethality of animals deficient either in caspase-8 or FADD, proteins involved in a pathway of apoptosis. This lethality is caused by a failure to develop the yolk sac vasculature rather than a lack of apoptosis. Remarkably, development is rescued by ablation of either of two Receptor Interacting Protein Kinases (RIPKs). Despite being well-known cell killers, caspase-8 and FADD act together to block RIPK-med...

  10. Hypokalemia and sudden cardiac death

    DEFF Research Database (Denmark)

    Kjeldsen, Keld

    2010-01-01

    Worldwide, approximately three million people suffer sudden cardiac death annually. These deaths often emerge from a complex interplay of substrates and triggers. Disturbed potassium homeostasis among heart cells is an example of such a trigger. Thus, hypokalemia and, also, more transient...... of fatal arrhythmia and sudden cardiac death a patient is, the more attention should be given to the potassium homeostasis....

  11. Trial Watch: Immunogenic cell death inducers for anticancer chemotherapy.

    Science.gov (United States)

    Pol, Jonathan; Vacchelli, Erika; Aranda, Fernando; Castoldi, Francesca; Eggermont, Alexander; Cremer, Isabelle; Sautès-Fridman, Catherine; Fucikova, Jitka; Galon, Jérôme; Spisek, Radek; Tartour, Eric; Zitvogel, Laurence; Kroemer, Guido; Galluzzi, Lorenzo

    2015-04-01

    The term "immunogenic cell death" (ICD) is now employed to indicate a functionally peculiar form of apoptosis that is sufficient for immunocompetent hosts to mount an adaptive immune response against dead cell-associated antigens. Several drugs have been ascribed with the ability to provoke ICD when employed as standalone therapeutic interventions. These include various chemotherapeutics routinely employed in the clinic (e.g., doxorubicin, epirubicin, idarubicin, mitoxantrone, bleomycin, bortezomib, cyclophosphamide and oxaliplatin) as well as some anticancer agents that are still under preclinical or clinical development (e.g., some microtubular inhibitors of the epothilone family). In addition, a few drugs are able to convert otherwise non-immunogenic instances of cell death into bona fide ICD, and may therefore be employed as chemotherapeutic adjuvants within combinatorial regimens. This is the case of cardiac glycosides, like digoxin and digitoxin, and zoledronic acid. Here, we discuss recent developments on anticancer chemotherapy based on ICD inducers.

  12. Flat mount preparation for observation and analysis of zebrafish embryo specimens stained by whole mount in situ hybridization.

    Science.gov (United States)

    Cheng, Christina N; Li, Yue; Marra, Amanda N; Verdun, Valerie; Wingert, Rebecca A

    2014-07-17

    The zebrafish embryo is now commonly used for basic and biomedical research to investigate the genetic control of developmental processes and to model congenital abnormalities. During the first day of life, the zebrafish embryo progresses through many developmental stages including fertilization, cleavage, gastrulation, segmentation, and the organogenesis of structures such as the kidney, heart, and central nervous system. The anatomy of a young zebrafish embryo presents several challenges for the visualization and analysis of the tissues involved in many of these events because the embryo develops in association with a round yolk mass. Thus, for accurate analysis and imaging of experimental phenotypes in fixed embryonic specimens between the tailbud and 20 somite stage (10 and 19 hours post fertilization (hpf), respectively), such as those stained using whole mount in situ hybridization (WISH), it is often desirable to remove the embryo from the yolk ball and to position it flat on a glass slide. However, performing a flat mount procedure can be tedious. Therefore, successful and efficient flat mount preparation is greatly facilitated through the visual demonstration of the dissection technique, and also helped by using reagents that assist in optimal tissue handling. Here, we provide our WISH protocol for one or two-color detection of gene expression in the zebrafish embryo, and demonstrate how the flat mounting procedure can be performed on this example of a stained fixed specimen. This flat mounting protocol is broadly applicable to the study of many embryonic structures that emerge during early zebrafish development, and can be implemented in conjunction with other staining methods performed on fixed embryo samples.

  13. Can generalized distribution factors lead to ''objective'' transmission toll allocations? Some lessons from the recent Chilean experience

    International Nuclear Information System (INIS)

    Galetovic, Alexander; Palma-Behnke, Rodrigo

    2008-01-01

    How to charge for transmission lines in a liberalized electricity market is still a conceptually unresolved issue and the literature offers many methods to determine who ''uses'' a given line and how to allocate tolls among users. But there seems to be some agreement that once a given method is chosen, calculating use and toll allocations is a mere technical matter. We suggest, by contrast that this belief is not warranted. We apply one power flow identification method - generalized load distribution factors - to allocate transmission tolls among the users of the Chilean transmission system and show that almost any allocation of tolls can be achieved by suitably choosing parameter values. Essentially, the method affords many degrees of freedom to the person responsible for setting the parameters needed to apply it. We argue that this suggests that setting parameter values is a central feature of transmission regulation. Moreover, our results suggest that an allocation method cannot answer the key unresolved question in the literature: what is the structure of tolls that gives economically adequate expansion incentives. (author)

  14. Brain Death in Islamic Jurisprudence

    Directory of Open Access Journals (Sweden)

    A Nikzad

    2016-07-01

    Full Text Available BACKGROUND AND OBJECTIVE: In today's world, Islamic jurisprudence encounters  new issues. One of the areas where jurisprudence gets involved is the issues concerned with brain death, whether brain death in jurisprudence and Islamic law is considered the end of life. In this study, brain death was discussed from the Shiite jurisprudence perspective and also the opinions of the specialists are taken into account. METHODS: This study is designed based on library collection and review of the literature in the field of brain death. Also, Quranic verses, hadiths and fatwas (religious opinions of the scholars are used. Some of the articles which were centered around Islamic jurisprudence, particularly Shiite jurisprudence that explain and deal with brain death were given special consideration. FINDINGS: Brain death from religious and jurisprudence perspective is considered the termination of life and removing the vital organs from the body is not viewed as committing manslaughter. A person with brain death is not a normally known injured man who is still alive. The brain death patinets have no life and getting rid of the body does not constitute a case of manslaughter. Amputation of the organs of brain death patients for donation and transplantation amounts to the amputation of a dead body. If the life of a Muslim is subject to transplant of organs from the body of a brain death patient, it will be permissible. CONCLUSION: In principle, if the life of a Muslim entails transplant of organs of brain death patients, it will be permissible 

  15. Sleep deprivation and divergent toll-like receptor-4 activation of cellular inflammation in aging.

    Science.gov (United States)

    Carroll, Judith E; Carrillo, Carmen; Olmstead, Richard; Witarama, Tuff; Breen, Elizabeth C; Yokomizo, Megumi; Seeman, Teresa; Irwin, Michael R

    2015-02-01

    Sleep disturbance and aging are associated with increases in inflammation, as well as increased risk of infectious disease. However, there is limited understanding of the role of sleep loss on age-related differences in immune responses. This study examines the effects of sleep deprivation on toll-like receptor activation of monocytic inflammation in younger compared to older adults. Community-dwelling adults (n = 70) who were categorized as younger (25-39 y old, n = 21) and older (60-84 y old, n = 49) participants, underwent a sleep laboratory-based experimental partial sleep deprivation (PSD) protocol including adaptation, an uninterrupted night of sleep, sleep deprivation (sleep restricted to 03:00-07:00), and recovery. Blood samples were obtained each morning to measure toll-like receptor-4 activation of monocyte intracellular production of the inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Partial sleep deprivation induced a significant increase in the production of IL-6 and/or TNF-α that persisted after a night of recovery sleep (F(2,121.2) = 3.8, P sleep loss, such that younger adults had an increase in inflammatory cytokine production that was not present in older adults (F(2,121.2) = 4.0, P sleep loss. Whereas sleep loss increases cellular inflammation in younger adults and may contribute to inflammatory disorders, blunted toll-like receptor activation in older adults may increase the risk of infectious disease seen with aging. © 2015 Associated Professional Sleep Societies, LLC.

  16. Hypothalamic neuronal toll-like receptor 2 protects against age-induced obesity

    OpenAIRE

    Shechter, Ravid; London, Anat; Kuperman, Yael; Ronen, Ayal; Rolls, Asya; Chen, Alon; Schwartz, Michal

    2013-01-01

    Toll-like receptors (TLRs) are traditionally associated with immune-mediated host defense. Here, we ascribe a novel extra-immune, hypothalamic-associated function to TLR2, a TLR-family member known to recognize lipid components, in the protection against obesity. We found that TLR2-deficient mice exhibited mature-onset obesity and susceptibility to high-fat diet (HFD)-induced weight gain, via modulation of food intake. Age-related obesity was still evident in chimeric mice, carrying comparabl...

  17. Toll-Like Receptor-2 Mediates Diet and/or Pathogen Associated Atherosclerosis: Proteomic Findings

    OpenAIRE

    Madan, Monika; Amar, Salomon

    2008-01-01

    Accumulating evidence implicates a fundamental link between the immune system and atherosclerosis. Toll-like receptors are principal sensors of the innate immune system. Here we report an assessment of the role of the TLR2 pathway in atherosclerosis associated with a high-fat diet and/or bacteria in ApoE(+/-) mice.To explore the role of TLR2 in inflammation- and infection-associated atherosclerosis, 10 week-old ApoE(+/-)-TLR2(+/+), ApoE(+/-)-TLR2(+/-) and ApoE(+/-)-TLR2(-/-) mice were fed eit...

  18. Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators

    Directory of Open Access Journals (Sweden)

    Lucía Pérez-Regidor

    2016-09-01

    Full Text Available This review aims to summarize the latest efforts performed in the search for novel chemical entities such as Toll-like receptor (TLR modulators by means of virtual screening techniques. This is an emergent research field with only very recent (and successful contributions. Identification of drug-like molecules with potential therapeutic applications for the treatment of a variety of TLR-regulated diseases has attracted considerable interest due to the clinical potential. Additionally, the virtual screening databases and computational tools employed have been overviewed in a descriptive way, widening the scope for researchers interested in the field.

  19. Toll-like receptor activation by helminths or helminth products to alleviate inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    Song YanXia

    2011-09-01

    Full Text Available Abstract Helminth infection may modulate the expression of Toll like receptors (TLR in dendritic cells (DCs and modify the responsiveness of DCs to TLR ligands. This may regulate aberrant intestinal inflammation in humans with helminthes and may thus help alleviate inflammation associated with human inflammatory bowel disease (IBD. Epidemiological and experimental data provide further evidence that reducing helminth infections increases the incidence rate of such autoimmune diseases. Fine control of inflammation in the TLR pathway is highly desirable for effective host defense. Thus, the use of antagonists of TLR-signaling and agonists of their negative regulators from helminths or helminth products should be considered for the treatment of IBD.

  20. Toll-like receptors and NOD-like receptors in rheumatic diseases.

    LENUS (Irish Health Repository)

    McCormack, William J

    2012-02-01

    The past 10 years have seen the description of families of receptors that drive proinflammatory cytokine production in infection and tissue injury. Two major classes have been examined in the context of inflammatory joint disease--the Toll-like receptors (TLRs) and NOD-like receptors (NLRs). TLRs such as TLR2 and TLR4 are being implicated in the pathology of rheumatoid arthritis, ankylosing spondylitis, lyme arthritis and osteoarthritis. Nalp3 has been identified as a key NLR for IL-1beta production and has been shown to have a particular role in gout. These findings present new therapeutic opportunities, possibly allowing for the replacement of biologics with small molecule inhibitors.

  1. PcToll3 was involved in anti-Vibrio response by regulating the expression of antimicrobial peptides in red swamp crayfish, Procambarus clarkii.

    Science.gov (United States)

    Lan, Jiang-Feng; Wei, Shun; Wang, Yu-Qing; Dai, Yun-Jia; Tu, Jia-Gang; Zhao, Li-Juan; Li, Xin-Cang; Qin, Qi-Wei; Chen, Nan; Lin, Li

    2016-10-01

    Tolls and Toll-like receptors (TLRs) play an important role in host immune defenses by regulating the expression of antimicrobial peptides (AMPs) and cytokines, but the functional differences of crustacean Tolls from Drosophila Tolls or Mammal TLRs are largely unknown. A novel Toll receptor, named PcToll3, was identified from red swamp crayfish, Procambarus clarkii. It was widely expressed in all detected tissues, and its transcript in hemocytes was up-regulated at 12 h after Vibrio parahemolyticus (Vibrio) injection or at 24 h post white spot syndrome virus (WSSV) challenge. After knockdown of PcToll3, the activity of bacterial clearance was inhibited, and the expression levels of AMPs including Crustin1 (Cru1), Anti-lippopolysaccharide factor 1 (ALF1), and Lysozymes1 (Lys1), which could be up-regulated by Vibrio, were all affected. Meanwhile, PcToll3 silencing influenced the expression of myeloid differentiation factor 88 (PcMyd88), tumor necrosis factor-associated factor 6 (PcTRAF6), and PcDorsal, which were the counterparts of Drosophila Toll signaling pathway. Interestingly, PcToll3 silencing inhibited translocation of PcDorsal from cytoplasm to nucleus. Furthermore, the knockdown of PcDorsal also impaired the expression of AMPs after Vibrio challenge. Hence, we concluded that, besides participating in antiviral immunity, PcToll3 might also regulate the expression of Cru1 and Lys1 to participate in anti-Vibrio immune responses by promoting PcDorsal translocation into nucleus. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Optimal Aging and Death

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Strulik, Holger

    2010-01-01

    health investments. At the same time, physiological aspects of the aging process influence optimal savings and health investment. We calibrate the model for the average US male in 2000 and proceed to show that the calibrated model accounts well for the cross-country link between labor productivity......This study introduces physiological aging into a simple model of optimal intertemporal consumption. In this endeavor we draw on the natural science literature on aging. According to the purposed theory, the speed of the aging process and the time of death are endogenously determined by optimal...... and life expectancy in the same year ("the Preston curve"); cross-country income differences can explain differences in life expectancy at age 20 of up to a decade. Moreover, technological change in health care of about 1.1% per year can account for the observed shift in the Preston curve between 1980...

  3. Organ donations after death

    Directory of Open Access Journals (Sweden)

    Bernarda Logar

    2003-09-01

    Full Text Available The paper discusses public opinion on post-mortem organ donation, especially the difference between high support of public opinion to transplant activity, its general readiness to donate organs and the low number of signed organ donor cards. Through different approaches the article tries to point out possible factors relevant to the decision to donate organs. Early studies showed demographic variables and information as significant factors when deciding to donate organs after death. As there was not enough evidence that long-term effect through these factors is significant, the need for new investigation has grown. Social cognition theories helped understanding the difference mentioned above. It seems that the use of this approach might contribute to the understanding the problem and to delimit most useful factors when working with public.

  4. Mounting of Biomaterials for Use in Ophthalmic Cell Therapies.

    Science.gov (United States)

    Harkin, Damien G; Dunphy, Siobhan E; Shadforth, Audra M A; Dawson, Rebecca A; Walshe, Jennifer; Zakaria, Nadia

    2017-11-01

    When used as scaffolds for cell therapies, biomaterials often present basic handling and logistical problems for scientists and surgeons alike. The quest for an appropriate mounting device for biomaterials is therefore a significant and common problem. In this review, we provide a detailed overview of the factors to consider when choosing an appropriate mounting device including those experienced during cell culture, quality assurance, and surgery. By way of example, we draw upon our combined experience in developing epithelial cell therapies for the treatment of eye diseases. We discuss commercially available options for achieving required goals and provide a detailed analysis of 4 experimental designs developed within our respective laboratories in Australia, the United Kingdom, and Belgium.

  5. Apparatus for mounting photovoltaic power generating systems on buildings

    Science.gov (United States)

    Russell, Miles C [Lincoln, MA

    2009-08-18

    Rectangular photovoltaic (PV) modules are mounted on a building roof by mounting stands that are distributed in rows and columns. Each stand comprises a base plate and first and second different height brackets attached to opposite ends of the base plate. Each first and second bracket comprises two module-support members. One end of each module is pivotally attached to and supported by a first module-support member of a first bracket and a second module-support member of another first bracket. At its other end each module rests on but is connected by flexible tethers to module-support members of two different second brackets. The tethers are sized to allow the modules to pivot up away from the module-support members on which they rest to a substantially horizontal position in response to wind uplift forces.

  6. Whole mount nuclear fluorescent imaging: convenient documentation of embryo morphology.

    Science.gov (United States)

    Sandell, Lisa L; Kurosaka, Hiroshi; Trainor, Paul A

    2012-11-01

    Here, we describe a relatively inexpensive and easy method to produce high quality images that reveal fine topological details of vertebrate embryonic structures. The method relies on nuclear staining of whole mount embryos in combination with confocal microscopy or conventional wide field fluorescent microscopy. In cases where confocal microscopy is used in combination with whole mount nuclear staining, the resulting embryo images can rival the clarity and resolution of images produced by scanning electron microscopy (SEM). The fluorescent nuclear staining may be performed with a variety of cell permeable nuclear dyes, enabling the technique to be performed with multiple standard microscope/illumination or confocal/laser systems. The method may be used to document morphology of embryos of a variety of organisms, as well as individual organs and tissues. Nuclear stain imaging imposes minimal impact on embryonic specimens, enabling imaged specimens to be utilized for additional assays. Copyright © 2012 Wiley Periodicals, Inc.

  7. Siting study for small platform-mounted industrial energy reactors

    International Nuclear Information System (INIS)

    1975-07-01

    Utilizing an existing 313 MW(t) ship propulsion reactor design, a concept has been formulated for a floating platform-mounted nuclear plant and an evaluation has been made to determine reductions in construction time and cost achievable by repetitive platform construction in a shipyard. Concepts and estimates are presented for siting platform-mounted nuclear plants at the location of industrial facilities where the nuclear plants would furnish industrial process heat and/or electrical power. The representative industrial site designated for this study is considered typical of sites that might be used along the extensive network of navigable canals adjacent to the ocean and is similar to potential sites along the inland waterways of the United States

  8. Preparation of source mounts for 4π counting

    International Nuclear Information System (INIS)

    Johnson, E.P.

    1991-01-01

    The 4πβ/γ counter in the ANSTO radioisotope standards laboratory at Lucas Heights constitutes part of the Australian national standard for radioactivity. Sources to be measured in the counter must be mounted on a substrate which is strong enough to withstand careful handling and transport. The substrate must also be electrically conducting to minimise counting errors caused by charging of the source, and it must have very low superficial density so that little or none of the radiation is absorbed. The entire process of fabrication of VYNS films, coating them with gold/palladium and transferring them to source mount rings, as carried out in the radioisotope standards laboratory, is documented. 3 refs., 2 tabs., 6 figs

  9. Righteousness and identity formation in the Sermon on the Mount

    Directory of Open Access Journals (Sweden)

    Francois P. Viljoen

    2013-03-01

    Full Text Available Righteousness is an important term in the first gospel and has a significant concentration in the Sermon on the Mount. The argument in this article is that the first gospel has a community building function. Matthew intentionally uses the word ‘righteousness’ in the Sermon on the Mount as an instrument to define the identity of his community. Though righteousness can be used in a soteriological sense, it is argued that Matthew mainly uses it in an ethical sense. By righteousness Matthew refers to the proper behavioural norms and attitudes for his community. Commitment to Jesus forms the central focus of the community’s identity. Their discipleship is demonstrated by doing the will of God as defined and interpreted by Jesus. Doing the will of God in such a manner is what Matthew regards as the distinguishing mark of this community. Thus they would surpass the righteousness of the scribes and Pharisees.

  10. Longitudinally mounted light emitting plasma in a dielectric resonator

    Energy Technology Data Exchange (ETDEWEB)

    Gilliard, Richard; DeVincentis, Marc; Hafidi, Abdeslam; O' Hare, Daniel; Hollingsworth, Gregg [LUXIM Corporation, 1171 Borregas Avenue, Sunnyvale, CA 94089 (United States)

    2011-06-08

    Methods for coupling power from a dielectric resonator to a light-emitting plasma have been previously described (Gilliard et al IEEE Trans. Plasma Sci. at press). Inevitably, regardless of the efficiency of power transfer, much of the emitted light is absorbed in the resonator itself which physically surrounds much if not all of the radiating material. An investigation into a method is presented here for efficiently coupling power to a longitudinally mounted plasma vessel which is mounted on the surface of the dielectric material of the resonator, thereby eliminating significant absorption of light within the resonator structure. The topology of the resonator and its physical properties as well as those of the metal halide plasma are presented. Results of basic models of the field configuration and plasma are shown as well as a configuration suitable as a practical light source.

  11. Tsunamis generated by eruptions from mount st. Augustine volcano, alaska.

    Science.gov (United States)

    Kienle, J; Kowalik, Z; Murty, T S

    1987-06-12

    During an eruption of the Alaskan volcano Mount St. Augustine in the spring of 1986, there was concern about the possibility that a tsunami might be generated by the collapse of a portion of the volcano into the shallow water of Cook Inlet. A similar edifice collapse of the volcano and ensuing sea wave occurred during an eruption in 1883. Other sea waves resulting in great loss of life and property have been generated by the eruption of coastal volcanos around the world. Although Mount St. Augustine remained intact during this eruptive cycle, a possible recurrence of the 1883 events spurred a numerical simulation of the 1883 sea wave. This simulation, which yielded a forecast of potential wave heights and travel times, was based on a method that could be applied generally to other coastal volcanos.

  12. Ground mounted photovoltaic installations. Guide for an impact study

    International Nuclear Information System (INIS)

    2011-01-01

    Legally, an impact study must be performed for ground mounted photovoltaic installations with a power greater than 250 kW. This guide is aimed at helping the actors of the photovoltaic sector to perform impact studies. After the description of the characteristics of a photovoltaic installation (principles, technical characteristics of a ground mounted installation, impact of photovoltaic systems on climate) and a presentation of the legal framework (European commitments, Grenelle de l'Environnement, applicable procedures), this report present the objectives and approach of an impact study, describes how the environment is taken into account from the early stages of a project, how the impact study is to be prepared. The last part describes the different components of the impact study: legal content, project description, analysis of the site initial status and environment, analysis of the project effects, rationale for the choice of the project

  13. The auriferous placer at Mount Robert, Pietersburg Greenstone belt

    International Nuclear Information System (INIS)

    Saager, R.; Muff, R.

    1986-01-01

    The Mount Robert gold placer near Potgietersrus occurs in coarse, matrix-supported conglomerates of the Uitkyk Formation within the Pietersburg greenstone belt. Sedimentological and mineralogical investigations indicate that the conglomerates and the ore minerals were derived from a greenstone provenance, and that they were deposited in a braided river environment within a rapidly subsiding trough. Lack of sedimentological concentration of the heavy minerals is considered to be the main reason for the low and erratic gold grades encountered (usually below 1 g/t) and, thus, the failure of all past mining ventures. The mineralogical composition of the Mount Robert ore closely resembles that of the Witwatersrand deposits. However, uraninite is absent, probably as a result of its complete removal by weathering processes. Remaining small uranium concentrations can still be detected within the conglomerates where they occur associated with grains of carbonaceous matter, leucoxene aggregates, and secondary iron-hydroxides. U3O8 values found in the conglomerates are given

  14. Fluorescent visualization of macromolecules in Drosophila whole mounts.

    Science.gov (United States)

    Ramos, Ricardo Guelerman Pinheiro; Machado, Luciana Claudia Herculano; Moda, Livia Maria Rosatto

    2010-01-01

    The ability to determine the expression dynamics of individual genes "in situ" by visualizing the precise spatial and temporal distribution of their products in whole mounts by histochemical and immunocytochemical reactions has revolutionized our understanding of cellular processes. Drosophila developmental genetics was one of the fields that benefited most from these technologies, and a variety of fluorescent methods were specifically designed for investigating the localization of developmentally important proteins and cell markers during embryonic and post embryonic stages of this model organism. In this chapter we present detailed protocols for fluorescence immunocytochemistry of whole mount embryos, imaginal discs, pupal retinas, and salivary glands of Drosophila melanogaster, as well as methods for fluorescent visualization of specific subcellular structures in these tissues.

  15. A lesson from Argentina: Setting transmission tolls in a competitive auction is much better than regulating them

    Energy Technology Data Exchange (ETDEWEB)

    Galetovic, Alexander [Facultad de Ciencias Economicas y Empresariales, Av. San Carlos de Apoquindo 2200, Santiago (Chile); Inostroza, Juan Ricardo [AES Gener S.A., Sanchez Fontecilla 310, piso 3, Santiago (Chile)

    2008-07-15

    There are at least two procedures for setting the tolls paid by power line users. One consists of regulating them in a standard process. The other, which is used in Argentina, involves auctioning the lines to the lowest toll. In this paper we show that an auction yields higher expected social welfare if n {>=} 2 bid. Expected social welfare is even higher if, as in Argentina, those who benefit from the line can also bid and build. Moreover, when the social welfare is utilitarian, an auction beats regulation even when the regulator can perfectly audit costs ex post. We describe and examine the auction of the fourth Comahue transmission line in Argentina. Assuming that the regulator's information about costs is similar to the information held by the industry, the model suggests that had tolls been regulated, they would have been at least 61% higher. (author)

  16. Binocular Rivalry in Helmet-Mounted Display Applications

    Science.gov (United States)

    1975-06-01

    research apparatus. 31 ., simple magnifying ophthalmic lenses were used, mounted in eyeglass frames. These were 2. 5 diopter lenses for both eyes to...wear eyeglasses with 2. 5 diopter lenses. The focal length of these lenses was 15. 5 inches and the eye waa accommodated at infinity when objects were...HMD luminance is positively related to I-I•D visibility, while ambient scene luminance bears an inverse relation- ship to HMD visibility. Scene

  17. Method to mount defect fuel elements i transport casks

    International Nuclear Information System (INIS)

    Borgers, H.; Deleryd, R.

    1996-01-01

    Leaching or otherwise failed fuel elements are mounted in special containers that fit into specially designed chambers in a transportation cask for transport to reprocessing or long-time storage. The fuel elements are entered into the container under water in a pool. The interior of the container is dried before transfer to the cask. Before closing the cask, its interior, and the exterior of the container are dried. 2 figs

  18. Apollo telescope mount thermal systems unit thermal vacuum test

    Science.gov (United States)

    Trucks, H. F.; Hueter, U.; Wise, J. H.; Bachtel, F. D.

    1971-01-01

    The Apollo Telescope Mount's thermal systems unit was utilized to conduct a full-scale thermal vacuum test to verify the thermal design and the analytical techniques used to develop the thermal mathematical models. Thermal vacuum test philosophy, test objectives configuration, test monitoring, environment simulation, vehicle test performance, and data correlation are discussed. Emphasis is placed on planning and execution of the thermal vacuum test with particular attention on problems encountered in conducting a test of this maguitude.

  19. Quality assurance during construction and mounting of the Balakovo NPP

    International Nuclear Information System (INIS)

    Savkin, A.I.; Vorob'ev, N.G.; Kugrysheva, M.A.

    1984-01-01

    Measures directed at opportune comissioning of the first unit of Balakovo NPP with the caracity 1000 MW(el.) are briefly described. A high quality of construction and mounting works is achieved due to a high level of engeneering preparation in the industry, organization of daily control over the works implementation and quality of products and materials supplied, by the improvement of automation and introduction of progressive forms of organization and remuneration

  20. Eddy current testing system for bottom mounted instrumentation welds

    OpenAIRE

    Kobayashi Noriyasu; Ueno Souichi; Suganuma Naotaka; Oodake Tatsuya; Maehara Takeshi; Kasuya Takashi; Ichikawa Hiroya

    2015-01-01

    The capability of eddy current testing (ECT) for the bottom mounted instrumentation (BMI) weld area of reactor vessel in a pressurized water reactor was demonstrated by the developed ECT system and procedure. It is difficult to position and move the probe on the BMI weld area because the area has complexly curved surfaces. The space coordinates and the normal vectors at the scanning points were calculated as the scanning trajectory of probe based on the measured results of surface shape on th...

  1. Isogloss: language and legacy on Mount St. Helens

    Science.gov (United States)

    E. Dodd

    2012-01-01

    Nothing standing aboveground today was here thirty years ago. The ground itself wasn't here. Oh, there was ground, but much of it lay below the surface where my boot soles slip a little in the loose pebbles of pumice. Rolling on loose rock and big ideas, for a moment I lose my sense of balance, glancing first at the sky above, then at the nearby peak of Mount St...

  2. Psychometric Assessment of Stereoscopic Head-Mounted Displays

    Science.gov (United States)

    2016-06-29

    Journal Article 3. DATES COVERED (From – To) Jan 2015 - Dec 2015 4. TITLE AND SUBTITLE PSYCHOMETRIC ASSESSMENT OF STEREOSCOPIC HEAD- MOUNTED DISPLAYS...to render an immersive three-dimensional constructive environment. The purpose of this effort was to quantify the impact of aircrew vision on an...simulated tasks requiring precise depth discrimination. This work will provide an example validation method for future stereoscopic virtual immersive

  3. Deaths: Leading Causes for 2011.

    Science.gov (United States)

    Heron, Melonie

    2015-07-27

    This report presents final 2011 data on the 10 leading causes of death in the United States by age, sex, race, and Hispanic origin. Leading causes of infant, neonatal, and postneonatal death are also presented. This report supplements ‘‘Deaths: Final Data for 2011,’’ the National Center for Health Statistics’ annual report of final mortality statistics. Data in this report are based on information from all death certificates filed in the 50 states and the District of Columbia in 2011. Causes of death classified by the International Classification of Diseases, 10th Revision (ICD–10) are ranked according to the number of deaths assigned to rankable causes. Cause-of-death statistics are based on the underlying cause of death. In 2011, the 10 leading causes of death were, in rank order: Diseases of heart; Malignant neoplasms; Chronic lower respiratory diseases; Cerebrovascular diseases; Accidents (unintentional injuries); Alzheimer’s disease; Diabetes mellitus; Influenza and pneumonia; Nephritis, nephrotic syndrome and nephrosis; and Intentional self-harm (suicide). They accounted for 74% of all deaths occurring in the United States. Differences in the rankings are evident by age, sex, race, and Hispanic origin. Leading causes of infant death for 2011 were, in rank order: Congenital malformations, deformations and chromosomal abnormalities; Disorders related to short gestation and low birth weight, not elsewhere classified; Sudden infant death syndrome; Newborn affected by maternal complications of pregnancy; Accidents (unintentional injuries); Newborn affected by complications of placenta, cord and membranes; Bacterial sepsis of newborn; Respiratory distress of newborn; Diseases of the circulatory system; and Neonatal hemorrhage. Important variations in the leading causes of infant death are noted for the neonatal and postneonatal periods. All material appearing in this report is in the public domain and may be reproduced or copied without permission

  4. Deaths: Leading Causes for 2015.

    Science.gov (United States)

    Heron, Melonie

    2017-11-01

    Objectives-This report presents final 2015 data on the 10 leading causes of death in the United States by age, sex, race, and Hispanic origin. Leading causes of infant, neonatal, and postneonatal death are also presented. This report supplements "Deaths: Final Data for 2015," the National Center for Health Statistics' annual report of final mortality statistics. Methods-Data in this report are based on information from all death certificates filed in the 50 states and the District of Columbia in 2015. Causes of death classified by the International Classification of Diseases, Tenth Revision (ICD-10) are ranked according to the number of deaths assigned to rankable causes. Cause-of-death statistics are based on the underlying cause of death. Results-In 2015, the 10 leading causes of death were, in rank order: Diseases of heart; Malignant neoplasms; Chronic lower respiratory diseases; Accidents (unintentional injuries); Cerebrovascular diseases; Alzheimer's disease; Diabetes mellitus; Influenza and pneumonia; Nephritis, nephrotic syndrome and nephrosis; and Intentional self-harm (suicide). They accounted for 74% of all deaths occurring in the United States. Differences in the rankings are evident by age, sex, race, and Hispanic origin. Leading causes of infant death for 2015 were, in rank order: Congenital malformations, deformations and chromosomal abnormalities; Disorders related to short gestation and low birth weight, not elsewhere classified; Sudden infant death syndrome; Newborn affected by maternal complications of pregnancy; Accidents (unintentional injuries); Newborn affected by complications of placenta, cord and membranes; Bacterial sepsis of newborn; Respiratory distress of newborn; Diseases of the circulatory system; and Neonatal hemorrhage. Important variations in the leading causes of infant death are noted for the neonatal and postneonatal periods. All material appearing in this report is in the public domain and may be reproduced or copied without

  5. Deaths: Leading Causes for 2013.

    Science.gov (United States)

    Heron, Melonie

    2016-02-16

    This report presents final 2013 data on the 10 leading causes of death in the United States by age, sex, race, and Hispanic origin. Leading causes of infant, neonatal, and postneonatal death are also presented. This report supplements "Deaths: Final Data for 2013," the National Center for Health Statistics’ annual report of final mortality statistics. Data in this report are based on information from all death certificates filed in the 50 states and the District of Columbia in 2013. Causes of death classified by the International Classification of Diseases, Tenth Revision (ICD–10) are ranked according to the number of deaths assigned to rankable causes. Cause-of-death statistics are based on the underlying cause of death. In 2013, the 10 leading causes of death were, in rank order: Diseases of heart; Malignant neoplasms; Chronic lower respiratory diseases; Accidents (unintentional injuries); Cerebrovascular diseases; Alzheimer’s disease; Diabetes mellitus; Influenza and pneumonia; Nephritis, nephrotic syndrome and nephrosis; and Intentional self-harm (suicide). They accounted for 74% of all deaths occurring in the United States. Differences in the rankings are evident by age, sex, race, and Hispanic origin. Leading causes of infant death for 2013 were, in rank order: Congenital malformations, deformations and chromosomal abnormalities; Disorders related to short gestation and low birth weight, not elsewhere classified; Newborn affected by maternal complications of pregnancy; Sudden infant death syndrome; Accidents (unintentional injuries); Newborn affected by complications of placenta, cord and membranes; Bacterial sepsis of newborn; Respiratory distress of newborn; Diseases of the circulatory system; and Neonatal hemorrhage. Important variations in the leading causes of infant death are noted for the neonatal and postneonatal periods. All material appearing in this report is in the public domain and may be reproduced or copied without permission; citation as

  6. Deaths: Leading Causes for 2012.

    Science.gov (United States)

    Heron, Melonie

    2015-08-31

    This report presents final 2012 data on the 10 leading causes of death in the United States by age, sex, race, and Hispanic origin. Leading causes of infant, neonatal, and postneonatal death are also presented. This report supplements "Deaths: Final Data for 2012," the National Center for Health Statistics' annual report of final mortality statistics. Data in this report are based on information from all death certificates filed in the 50 states and the District of Columbia in 2012. Causes of death classified by the International Classification of Diseases, Tenth Revision (ICD-10) are ranked according to the number of deaths assigned to rankable causes. Cause-of-death statistics are based on the underlying cause of death. In 2012, the 10 leading causes of death were, in rank order: Diseases of heart; Malignant neoplasms; Chronic lower respiratory diseases; Cerebrovascular diseases; Accidents (unintentional injuries); Alzheimer's disease; Diabetes mellitus; Influenza and pneumonia; Nephritis, nephrotic syndrome and nephrosis; and Intentional self-harm (suicide). These causes accounted for 74% of all deaths occurring in the United States. Differences in the rankings are evident by age, sex, race, and Hispanic origin. Leading causes of infant death for 2012 were, in rank order: Congenital malformations, deformations and chromosomal abnormalities; Disorders related to short gestation and low birth weight, not elsewhere classified; Sudden infant death syndrome; Newborn affected by maternal complications of pregnancy; Accidents (unintentional injuries); Newborn affected by complications of placenta, cord and membranes; Bacterial sepsis of newborn; Respiratory distress of newborn; Diseases of the circulatory system; and Neonatal hemorrhage. Important variations in the leading causes of infant death are noted for the neonatal and postneonatal periods.

  7. Conceptual Design of Bottom-mounted Control Rod Drive Mechanism

    International Nuclear Information System (INIS)

    Lee, Jin Haeng; Kim, Sanghaun; Yoo, Yeonsik; Cho, Yeonggarp; Kim, Dongmin; Kim, Jong In

    2013-01-01

    The arrangement of the BMCRDMs and irradiation holes in the core is therefore easier than that of the top-mounted CRDM. Hence, many foreign research reactors, such as JRR-3M, JMTR, OPAL, and CARR, have adopted the BMCRDM concept. The purpose of this paper is to introduce the basic design concept on the BMCRDM. The major differences of the CRDMs between HANARO and KJRR are compared, and the design features and individual system of the BMCRDM for the KJRR are described. The Control Rod Drive Mechanism (CRDM) is a device to regulate the reactor power by changing the position of a Control Absorber Rod (CAR) and to shut down the reactor by fully inserting the CAR into the core within a specified time. The Bottom-Mounted CRDM (BMCRDM) for the KiJang Research Reactor (KJRR) is a quite different design concept compared to the top-mounted CRDM such as HANARO and JRTR. The main drive mechanism of the BMCRDM is located in a Reactivity Control Mechanism (RCM) room under the reactor pool bottom, which makes the interference with equipment in the reactor pool reduced

  8. A concept of active mount for space applications

    Science.gov (United States)

    Souleille, A.; Lampert, T.; Lafarga, V.; Hellegouarch, S.; Rondineau, A.; Rodrigues, G.; Collette, C.

    2018-06-01

    Sensitive payloads mounted on top of launchers are subjected to many sources of disturbances during the flight. The most severe dynamic loads arise from the ignition of the motors, gusts, pressure fluctuations in the booster and from the separation of the boosters. The transmission of these dynamic forces can be reduced by mounting payloads on passive isolators, which comes at the expense of harmful amplifications of the motion at low frequency due to suspension resonances. To bypass this shortcoming, this paper presents a novel concept of active mount for aerospace payloads, which is easy to install, and meets two objectives. The first one is a high damping authority on both suspension resonances and flexible resonances without compromising the isolation and large stability margins of the closed loop system due to the collocation of the actuator and the sensor. The second one is a broadband reduction of the dynamic force transmitted to the payload, which was achieved in terms of 16 dB. The concept is presented in the first part of the paper and studied numerically and experimentally on a single degree of freedom isolator. A commercial isolator has been chosen for the purpose of the demonstration. The second part of the paper is dedicated to experimental validations on multi-degree of freedom scaled test benches. It is shown that the force feedback allows damping of both suspension and flexible modes (first and second modes, respectively), and significantly reducing the force transmitted in some broad frequency ranges.

  9. On-field mounting position estimation of a lidar sensor

    Science.gov (United States)

    Khan, Owes; Bergelt, René; Hardt, Wolfram

    2017-10-01

    In order to retrieve a highly accurate view of their environment, autonomous cars are often equipped with LiDAR sensors. These sensors deliver a three dimensional point cloud in their own co-ordinate frame, where the origin is the sensor itself. However, the common co-ordinate system required by HAD (Highly Autonomous Driving) software systems has its origin at the center of the vehicle's rear axle. Thus, a transformation of the acquired point clouds to car co-ordinates is necessary, and thereby the determination of the exact mounting position of the LiDAR system in car coordinates is required. Unfortunately, directly measuring this position is a time-consuming and error-prone task. Therefore, different approaches have been suggested for its estimation which mostly require an exhaustive test-setup and are again time-consuming to prepare. When preparing a high number of LiDAR mounted test vehicles for data acquisition, most approaches fall short due to time or money constraints. In this paper we propose an approach for mounting position estimation which features an easy execution and setup, thus making it feasible for on-field calibration.

  10. Local Sabahans’ Satisfaction with Level of Access to Mount Kinabalu

    Directory of Open Access Journals (Sweden)

    Bidder Christy

    2014-01-01

    Full Text Available This study analyzes the local Sabahans’ satisfaction with the level of access to Mount Kinabalu in Sabah, Malaysian Borneo. Specifically, it examines the number of complaints by local Sabahans regarding access and their perception of changes in accessibility to the mountain. Interviews with Sabah Parks and Sutera Sanctuary Lodges were conducted and questionnaires were distributed to local residents to collect data. The results show that there were intense complaints regarding the climbing cost and extensive waiting time to secure a confirmed booking at the outset of price increases. However, the researchers could not locate any recently published complaints. Respondents who have previously climbed Mount Kinabalu perceive the mountain to be less accessible for local Sabahans now due to a less affordable cost and a longer waiting time. Those who have not climbed Mount Kinabalu also think the climbing cost has become less affordable for local Sabahans, but they do not perceive that to be causing the mountain less accessible for local Sabahans.

  11. A concept of active mount for space applications

    Science.gov (United States)

    Souleille, A.; Lampert, T.; Lafarga, V.; Hellegouarch, S.; Rondineau, A.; Rodrigues, G.; Collette, C.

    2017-10-01

    Sensitive payloads mounted on top of launchers are subjected to many sources of disturbances during the flight. The most severe dynamic loads arise from the ignition of the motors, gusts, pressure fluctuations in the booster and from the separation of the boosters. The transmission of these dynamic forces can be reduced by mounting payloads on passive isolators, which comes at the expense of harmful amplifications of the motion at low frequency due to suspension resonances. To bypass this shortcoming, this paper presents a novel concept of active mount for aerospace payloads, which is easy to install, and meets two objectives. The first one is a high damping authority on both suspension resonances and flexible resonances without compromising the isolation and large stability margins of the closed loop system due to the collocation of the actuator and the sensor. The second one is a broadband reduction of the dynamic force transmitted to the payload, which was achieved in terms of 16 dB. The concept is presented in the first part of the paper and studied numerically and experimentally on a single degree of freedom isolator. A commercial isolator has been chosen for the purpose of the demonstration. The second part of the paper is dedicated to experimental validations on multi-degree of freedom scaled test benches. It is shown that the force feedback allows damping of both suspension and flexible modes (first and second modes, respectively), and significantly reducing the force transmitted in some broad frequency ranges.

  12. Conceptual Design of Bottom-mounted Control Rod Drive Mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jin Haeng; Kim, Sanghaun; Yoo, Yeonsik; Cho, Yeonggarp; Kim, Dongmin; Kim, Jong In [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-05-15

    The arrangement of the BMCRDMs and irradiation holes in the core is therefore easier than that of the top-mounted CRDM. Hence, many foreign research reactors, such as JRR-3M, JMTR, OPAL, and CARR, have adopted the BMCRDM concept. The purpose of this paper is to introduce the basic design concept on the BMCRDM. The major differences of the CRDMs between HANARO and KJRR are compared, and the design features and individual system of the BMCRDM for the KJRR are described. The Control Rod Drive Mechanism (CRDM) is a device to regulate the reactor power by changing the position of a Control Absorber Rod (CAR) and to shut down the reactor by fully inserting the CAR into the core within a specified time. The Bottom-Mounted CRDM (BMCRDM) for the KiJang Research Reactor (KJRR) is a quite different design concept compared to the top-mounted CRDM such as HANARO and JRTR. The main drive mechanism of the BMCRDM is located in a Reactivity Control Mechanism (RCM) room under the reactor pool bottom, which makes the interference with equipment in the reactor pool reduced.

  13. Vibration aging of diesel-engine mounted electrical equipment

    International Nuclear Information System (INIS)

    Lee, B.J.; Morton, W.C.

    1994-01-01

    The Emergency Diesel Generator (EDG) in a Nuclear Power Plant is considered to be a component which is essential to safe plant operation. Failures of auxiliary equipment directly mounted on the EDG creates costly repairs, and compromises the engine's availability and reliability. Although IEEE-323 requires addressing of safety-related components due to mechanically induced vibration, very few guidelines exist in the nuclear industry to show how this may be accounted for. Most engine vendors rely on the empirical experience data as the basis of their evaluation for vibration. Upgrade of engine controls, addition of monitoring devices and other engine modifications require design and installation of new equipment to be mounted directly on the engine. This necessitates the evaluation for engine-induced vibration which is considered to be one of the most severe design parameters. This paper discusses the engine vibration characteristics, and the acquisition of extensive field vibration data on the diesel engine under operating conditions. The data is then used to develop life cycle vibration qualification test profiles that can be applied with confidence in a laboratory environment to qualify engine-mounted equipment. The intent is to validate a product's ability to survive under worst case, extended service on-engine conditions. This paper describes the procedures and approaches used to achieve those goals, and provides developed profile examples and test results

  14. The Observatory as Laboratory: Spectral Analysis at Mount Wilson Observatory

    Science.gov (United States)

    Brashear, Ronald

    2018-01-01

    This paper will discuss the seminal changes in astronomical research practices made at the Mount Wilson Observatory in the early twentieth century by George Ellery Hale and his staff. Hale’s desire to set the agenda for solar and stellar astronomical research is often described in terms of his new telescopes, primarily the solar tower observatories and the 60- and 100-inch telescopes on Mount Wilson. This paper will focus more on the ancillary but no less critical parts of Hale’s research mission: the establishment of associated “physical” laboratories as part of the observatory complex where observational spectral data could be quickly compared with spectra obtained using specialized laboratory equipment. Hale built a spectroscopic laboratory on the mountain and a more elaborate physical laboratory in Pasadena and staffed it with highly trained physicists, not classically trained astronomers. The success of Hale’s vision for an astronomical observatory quickly made the Carnegie Institution’s Mount Wilson Observatory one of the most important astrophysical research centers in the world.

  15. Design and functional tests of the Euclid grism mount

    Science.gov (United States)

    Rossin, Ch.; Grange, R.; Caillat, A.; Costille, A.; Sanchez, P.; Ceria, W.

    2017-11-01

    The Euclid mission selected by ESA in the Cosmic Vision program is dedicated to understand dark energy and dark matter. One of the probes based on detection of Baryonic Acoustic Oscillations required the redshift of millions of galaxies. This massive spectroscopic survey relies on the Near Infrared SpectroPhotometer (NISP) using grism in slitless mode. In this Euclid NISP context, we designed a cryogenic mount for the four grisms of the spectroscopic channel. This mount has to maintain optical performances and alignment at the cryogenic temperature of 120K and to survive launch vibrations. Due to a very small mass and volume budget allowed in the Grism Wheel Assembly our design relies on a weight relief Invar ring glued to the grism by tangential flexures. Tangential flexures have the advantage of small height but the drawback of less decoupling capabilities than bipods. We will present the design of the mount and the integration and functional tests to stay within the 60 nm RMS transmitted wavefront error budget allowed to the grism.

  16. Preventing the premature death of relationship marketing.

    Science.gov (United States)

    Fournier, S; Dobscha, S; Mick, D G

    1998-01-01

    Relationship marketing is in vogue. And why not? The new, increasingly efficient ways that companies have of understanding and responding to customers' needs and preferences seemingly allow them to build more meaningful connections with consumers than ever before. These connections promise to benefit the bottom line by reducing costs and increasing revenue. Unfortunately, a close look suggests that the relationships between companies and customers are troubled ones, at best. Companies may delight in learning more about their customers and in being able to provide features and services to please every possible palate. But customers delight in neither. In fact, customer satisfaction rates in the United States are at an all-time low, while complaints, boycotts, and other expressions of consumer discontent are on the rise. This mounting wave of unhappiness has yet to reach the bottom line. Sooner or later, however, corporate performance will suffer unless relationship marketing becomes what it is supposed to be--the epitome of customer orientation. Ironically, the very things that marketers are doing to build relationships with customers are often the things that are destroying those relationships. Relationship marketing is powerful in theory but troubled in practice. To prevent its premature death, marketers need to take the time to figure out how and why they are undermining their own best efforts, as well as how they can get things back on track.

  17. Let-7i attenuates human brain microvascular endothelial cell damage in oxygen glucose deprivation model by decreasing toll-like receptor 4 expression.

    Science.gov (United States)

    Xiang, Wei; Tian, Canhui; Peng, Shunli; Zhou, Liang; Pan, Suyue; Deng, Zhen

    2017-11-04

    The let-7 family of microRNAs (miRNAs) plays an important role on endothelial cell function. However, there have been few studies on their role under ischemic conditions. In this study, we demonstrate that let-7i, belonging to the let-7 family, rescues human brain microvascular endothelial cells (HBMECs) in an oxygen-glucose deprivation (OGD) model. Our data show that the expression of let-7 family miRNAs was downregulated after OGD. Overexpression of let-7i significantly alleviated cell death and improved survival of OGD-treated HBMECs. Let-7i also protected permeability in an in vitro blood brain barrier (BBB) model. Further, let-7i downregulated the expression of toll-like receptor 4 (TLR4), an inflammation trigger. Moreover, overexpression of let-7i decreased matrix metallopeptidase 9 (MMP9) and inducible nitric oxide synthase (iNOS) expression under OGD. Upon silencing TLR4 expression in HBMECs, the anti-inflammatory effect of let-7i was abolished. Our research suggests that let-7i promotes OGD-induced inflammation via downregulating TLR4 expression. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens

    Science.gov (United States)

    Martínez, Isidoro; Oliveros, Juan C.; Cuesta, Isabel; de la Barrera, Jorge; Ausina, Vicente; Casals, Cristina; de Lorenzo, Alba; García, Ernesto; García-Fojeda, Belén; Garmendia, Junkal; González-Nicolau, Mar; Lacoma, Alicia; Menéndez, Margarita; Moranta, David; Nieto, Amelia; Ortín, Juan; Pérez-González, Alicia; Prat, Cristina; Ramos-Sevillano, Elisa; Regueiro, Verónica; Rodriguez-Frandsen, Ariel; Solís, Dolores; Yuste, José; Bengoechea, José A.; Melero, José A.

    2017-01-01

    Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here. PMID:28298903

  19. Andrographolide suppresses TRIF-dependent signaling of toll-like receptors by targeting TBK1.

    Science.gov (United States)

    Kim, Ah-Yeon; Shim, Hyun-Jin; Shin, Hyeon-Myeong; Lee, Yoo Jung; Nam, Hyeonjeong; Kim, Su Yeon; Youn, Hyung-Sun

    2018-04-01

    Toll-like receptors (TLRs) play a crucial role in danger recognition and induction of innate immune response against bacterial and viral infections. The TLR adaptor molecule, toll-interleukin-1 receptor domain-containing adapter inducing interferon-β (TRIF), facilitates TLR3 and TLR4 signaling, leading to the activation of the transcription factor, NF-κB and interferon regulatory factor 3 (IRF3). Andrographolide, the active component of Andrographis paniculata, exerts anti-inflammatory effects; however, the principal molecular mechanisms remain unclear. The objective of this study was to investigate the role of andrographolide in TLR signaling pathways. Andrographolide suppressed NF-κB activation as well as COX-2 expression induced by TLR3 or TLR4 agonists. Andrographolide also suppressed the activation of IRF3 and the expression of interferon inducible protein-10 (IP-10) induced by TLR3 or TLR4 agonists. Andrographolide attenuated ligand-independent activation of IRF3 following overexpression of TRIF, TBK1, or IRF3. Furthermore, andrographolide inhibited TBK1 kinase activity in vitro. These results indicate that andrographolide modulates the TRIF-dependent pathway of TLRs by targeting TBK1 and represents a potential new anti-inflammatory candidate. Copyright © 2018 Elsevier B.V. All rights reserved.

  20. Challenges of raising road maintenance funds in developing countries: An analysis of road tolling in Zimbabwe

    Directory of Open Access Journals (Sweden)

    T. C. Mbara

    2010-11-01

    Full Text Available The condition of Zimbabwe's roads has been declining due to insufficient maintenance and rehabilitation. Year on year, budget allocations have compared unfavourably with funding considered adequate to maintain highway networks and conduct modest construction work. Road infrastructure shortcomings have manifested themselves in the form of high vehicle operating costs and rampant potholes, leading to a decline in road safety and a deterioration of service levels for those who use roads to deliver goods or connect to international markets. In order to try and stop this vicious cycle of decline, the Government of Zimbabwe, on 8 August 2009, introduced a new policy of road-user charges, which involved the setting-up of 22 toll gates on the trunk road network. The overall objective was to raise revenue in order to close the funding gap, blamed for declining road quality. Although alternative methods of financing road maintenance have been debated for years, a generally accepted understanding is that road users should pay costs for road provisioning. This paper assesses the implementation of a road tolling system in Zimbabwe and describes matters relating to, inter alia, implementation strategy, initial performance outcomes and sustainability.