miR-958 inhibits Toll signaling and Drosomycin expression via direct targeting of Toll and Dif in Drosophila melanogaster.

Science.gov (United States)

Li, Shengjie; Li, Yao; Shen, Li; Jin, Ping; Chen, Liming; Ma, Fei

2017-02-01

Drosophila melanogaster is widely used as a model system to study innate immunity and signaling pathways related to innate immunity, including the Toll signaling pathway. Although this pathway is well studied, the precise mechanisms of posttranscriptional regulation of key components of the Toll signaling pathway by microRNAs (miRNAs) remain obscure. In this study, we used an in silico strategy in combination with the Gal80 ts -Gal4 driver system to identify microRNA-958 (miR-958) as a candidate Toll pathway regulating miRNA in Drosophila We report that overexpression of miR-958 significantly reduces the expression of Drosomycin, a key antimicrobial peptide involved in Toll signaling and the innate immune response. We further demonstrate in vitro and in vivo that miR-958 targets the Toll and Dif genes, key components of the Toll signaling pathway, to negatively regulate Drosomycin expression. In addition, a miR-958 sponge rescued the expression of Toll and Dif, resulting in increased expression of Drosomycin. These results, not only revealed a novel function and modulation pattern of miR-958, but also provided a new insight into the underlying molecular mechanisms of Toll signaling in regulation of innate immunity. Copyright © 2017 the American Physiological Society.

Toll Facilities in the United States

Data.gov (United States)

Department of Transportation — Biennial report containing selected information on toll facilities in the United States that has been provided to FHWA by the States and/or various toll authorities...

Shadow Toll in Colombia

OpenAIRE

González Ruiz, Juan David; Botero Botero, Sergio; Arboleda, Carlos Alejandro; Duque Grisales, Eduardo Alexander

2015-01-01

The growing development in infrastructure projects in Colombia has been linked to legal adjustments and capital markets. These two last factors have provided important elements for project developers to design funding strategies. Based on the shadow toll scheme, this paper proposes a new financing strategy for funding highway projects. This strategy may be implemented in Colombia. Finally, the paper proposes future research on shadow toll schemes as a financial mechanism.

47 CFR 42.6 - Retention of telephone toll records.

Science.gov (United States)

2010-10-01

... whether it is billing its own toll service customers for toll calls or billing customers for another... Section 42.6 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES... telephone toll records. Each carrier that offers or bills toll telephone service shall retain for a period...

Technology scan for electronic toll collection.

Science.gov (United States)

2008-06-01

The purpose of this project was to identify and assess available technologies and methodologies for electronic toll collection (ETC) and to develop recommendations for the best way(s) to implement toll collection in the Louisville metropolitan area. ...

The Theoretical and Applied Fundamentals of Management of Tolling Operations

Directory of Open Access Journals (Sweden)

Melnyk Olha H.

2018-01-01

Full Text Available The article is concerned with identification of the unified essence of tolling operations in the scientific terminological apparatus; substantiation of conceptual bases of balanced management of tolling operations; characterization of the current status and tendencies of development of tolling operations at domestic enterprises; allocation and analyzing of factors of influence on tolling operations, and also economic assessment of tolling operations of the processing enterprise. The concept of balanced management of tolling operations has been substantiated, on parity basis considering interests of the customer and executor of processing works. The most essential internal and external factors of influence on tolling operations have been identified and their influence has been interpreted by means of the developed correlation-regression dependencies. The complex model of economic diagnostics of tolling operations of processing enterprise has been improved, allowing to assess efficiency of their implementation both operatively and fundamentally. Prospect for further research is development of an instrumentarium of motivation of participants of tolling operations in order to increase motivation of employees to the efficient implementation of these operations.

23 CFR 950.5 - Requirement to use electronic toll collection technology.

Science.gov (United States)

2010-04-01

... shall use an electronic toll collection system as the method for collecting tolls from vehicle operators... 23 Highways 1 2010-04-01 2010-04-01 false Requirement to use electronic toll collection technology... TRANSPORTATION SYSTEMS ELECTRONIC TOLL COLLECTION § 950.5 Requirement to use electronic toll collection...

Disseminated cysticercosis: clinical spectrum, Toll-like receptor-4 gene polymorphisms and role of albendazole

Science.gov (United States)

Qavi, Abdul; Garg, Ravindra Kumar; Malhotra, Hardeep Singh; Jain, Amita; Kumar, Neeraj; Malhotra, Kiran Preet; Srivastava, Pradeep Kumar; Verma, Rajesh; Sharma, Praveen Kumar

2016-01-01

Abstract In this study, we describe clinical and imaging spectrum, and the natural course of patients with disseminated cysticercosis. How albendazole affects the course of disease has also been evaluated. We assessed the Toll-like receptor-4 gene polymorphisms, to know the reason for the apparently higher prevalence of disseminated cysticercosis in India. Sixty consecutive patients with disseminated cysticercosis were enrolled. Sixty age-and-sex-matched healthy controls were also enrolled for the purpose of genetic study. Twenty patients, who gave consent, were treated with albendazole along with corticosteroids. Forty patients did not give consent for antiparasitic therapy. Assessment for Toll-like receptor-4 gene polymorphisms (Asp299Gly and Thr399Ile genes) was done. Patients were followed for 6 months. We also performed a literature search of cases published in English language using PubMed electronic database and analyzed 56 cases thus available. There was an increased risk (6.63 fold and 4.61 fold) of disseminated cysticercosis in the presence of Asp299Gly and Thr399Ile polymorphisms in Toll-like receptor-4, respectively. The allelic frequency of Gly (11% vs. 3%, P = 0.024, odds ratio [OR] = 3.52) and Ile alleles (11% vs. 2%, P = 0.009, OR = 4.738) in disseminated cysticercosis was high. Albendazole resulted in complete disappearance of all cerebral lesions in 35% (7/20) patients and reduction in lesion load in remaining 65% (13/20) patients. No significant change in number of cysticercal lesion was noted in patients who did not receive albendazole. No major adverse reaction following antiparasitic treatment was noted. Three deaths were recorded in patients who did not receive antiparasitic treatment. Of the 56 cases reported in PubMed, 33 patients received antiparasitic treatment with follow-up data available for 31 patients. Most (24) of these patients received albendazole. A significant clinical and/or imaging improvements, on follow up, were observed in

Crosstalk between complement and Toll-like receptor activation in relation to donor brain death and renal ischemia-reperfusion injury.

Science.gov (United States)

Damman, Jeffrey; Daha, Mohamed R; van Son, Willem J; Leuvenink, Henri G; Ploeg, Rutger J; Seelen, Marc A

2011-04-01

Two central pathways of innate immunity, complement and Toll-like receptors (TLRs), play an important role in the pathogenesis of renal injury inherent to kidney transplantation. Recent findings indicate close crosstalk between complement and TLR signaling pathways. It is suggested that mitogen activated protein kinases (MAPKs) might be the key molecules linking both the complement and TLR pathways together. Complement and TLRs are important mediators of renal ischemia-reperfusion injury (IRI). Besides IRI, complement C3 can also be upregulated and activated in the kidney before transplantation as a direct result of brain death (BD) in the donor. This local upregulation and activation of complement in the donor kidney has been proven to be detrimental for renal allograft outcome. Also TLR4 and several of its major ligands are upregulated by donor BD compared to living donors. Important and in line with the observations above, kidney transplant recipients have a benefit when receiving a kidney from a TLR4 Asp299Gly/Thr399Ile genotypic donor. The role of complement and TLRs and crosstalk between these two innate immune systems in relation to renal injury during donor BD and ischemia-reperfusion are focus of this review. Future strategies to target complement and TLR activation in kidney transplantation are considered. ©2011 The Authors Journal compilation©2011 The American Society of Transplantation and the American Society of Transplant Surgeons.

Crosstalk between Complement and Toll-like Receptor Activation in Relation to Donor Brain Death and Renal Ischemia-Reperfusion Injury

NARCIS (Netherlands)

Damman, Jeffrey; Daha, Mohamed R.; van Son, Willem J.; Leuvenink, Henri G.; Ploeg, Rutger J.; Seelen, Marc A.

Two central pathways of innate immunity, complement and Toll-like receptors (TLRs), play an important role in the pathogenesis of renal injury inherent to kidney transplantation. Recent findings indicate close crosstalk between complement and TLR signaling pathways. It is suggested that mitogen

Absence of Toll-Like Receptor 4 Signaling Results in Delayed Yersinia enterocolitica YopP-Induced Cell Death of Dendritic Cells

Czech Academy of Sciences Publication Activity Database

Gröbner, S.; Schulz, S.; Adkins, Irena; Gunst, D. S. J.; Waibel, M.; Wesselborg, S.; Borgmann, S.; Autenrieth, I. B.

2007-01-01

Roč. 75, č. 1 (2007), s. 512-517 ISSN 0019-9567 Institutional research plan: CEZ:AV0Z50200510 Keywords : yersinia enterocolitica * toll-like receptor 4 * dendritic cell s Subject RIV: EC - Immunology Impact factor: 3.996, year: 2007

Toll-like receptors in neonatal sepsis.

LENUS (Irish Health Repository)

O'Hare, Fiona M

2013-06-01

Toll-like receptors are vital transmembrane receptors that initiate the innate immune response to many micro-organisms. The discovery of these receptors has improved our understanding of host-pathogen interactions, and these receptors play an important role in the pathogenesis of multiple neonatal conditions such as sepsis and brain injury. Toll-like receptors, especially TLRs 2 and 4, are associated with necrotizing enterocolitis, periventricular leukomalacia and sepsis.

Solution structure of the isolated Pelle death domain.

Science.gov (United States)

Moncrieffe, Martin C; Stott, Katherine M; Gay, Nicholas J

2005-07-18

The interaction between the death domains (DDs) of Tube and the protein kinase Pelle is an important component of the Toll pathway. Published crystallographic data suggests that the Pelle-Tube DD interface is plastic and implies that in addition to the two predominant Pelle-Tube interfaces, a third interaction is possible. We present the NMR solution structure of the isolated death domain of Pelle and a study of the interaction between the DDs of Pelle and Tube. Our data suggests the solution structure of the isolated Pelle DD is similar to that of Pelle DD in complex with Tube. Additionally, they suggest that the plasticity observed in the crystal structure may not be relevant in the functioning death domain complex.

Autophagic components contribute to hypersensitive cell death in Arabidopsis

DEFF Research Database (Denmark)

Hofius, Daniel; Schultz-Larsen, Torsten; Joensen, Jan

2009-01-01

Autophagy has been implicated as a prosurvival mechanism to restrict programmed cell death (PCD) associated with the pathogen-triggered hypersensitive response (HR) during plant innate immunity. This model is based on the observation that HR lesions spread in plants with reduced autophagy gene...... expression. Here, we examined receptor-mediated HR PCD responses in autophagy-deficient Arabidopsis knockout mutants (atg), and show that infection-induced lesions are contained in atg mutants. We also provide evidence that HR cell death initiated via Toll/Interleukin-1 (TIR)-type immune receptors through...... the defense regulator EDS1 is suppressed in atg mutants. Furthermore, we demonstrate that PCD triggered by coiled-coil (CC)-type immune receptors via NDR1 is either autophagy-independent or engages autophagic components with cathepsins and other unidentified cell death mediators. Thus, autophagic cell death...

DMPD: Translational mini-review series on Toll-like receptors: networks regulated byToll-like receptors mediate innate and adaptive immunity. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17223959 Translational mini-review series on Toll-like receptors: networks regulate...ol. 2007 Feb;147(2):199-207. (.png) (.svg) (.html) (.csml) Show Translational mini-review series on Toll-lik... immunity. PubmedID 17223959 Title Translational mini-review series on Toll-like receptors: networks regulat

Drosophila Ninjurin A induces nonapoptotic cell death.

Directory of Open Access Journals (Sweden)

Sarah Broderick

Full Text Available Ninjurins are conserved transmembrane proteins that are upregulated across species in response to injury and stress. Their biological functions are not understood, in part because there have been few in vivo studies of their function. We analyzed the expression and function of one of three Drosophila Ninjurins, NijA. We found that NijA protein is redistributed to the cell surface in larval immune tissues after septic injury and is upregulated by the Toll pathway. We generated a null mutant of NijA, which displayed no detectable phenotype. In ectopic expression studies, NijA induced cell death, as evidenced by cell loss and acridine orange staining. These dying cells did not display hallmarks of apoptotic cells including TUNEL staining and inhibition by p35, indicating that NijA induced nonapoptotic cell death. In cell culture, NijA also induced cell death, which appeared to be cell autonomous. These in vivo studies identify a new role for the Ninjurin family in inducing nonapoptotic cell death.

Toll-like receptors in brain development and homeostasis

DEFF Research Database (Denmark)

Larsen, Peter H; Holm, Thomas Hellesøe; Owens, Trevor

2007-01-01

Toll-like receptors (TLRs) are best known as initiators of the innate immune response to pathogens. Recent reports now reveal intriguing roles for TLRs in the central nervous system (CNS). These include the regulation of neuroinflammation and of neurite outgrowth. The archetypal Toll protein in D...

Operation Iraqi Freedom/Operation Enduring Freedom: exploring wartime death and bereavement.

Science.gov (United States)

Harrington Lamorie, Jill

2011-01-01

Military deaths are often sudden, unanticipated, traumatic, and/or violent in nature and involve the death of a young adult. More than 5,500 service members have died as a result of their service in the wars in Afghanistan (2001) and Iraq (2003) in combat- or non-combat- related incidences. As the death toll continues to rise, service members and their families struggle with the visible and invisible wounds of war. This article explores wartime death, trauma, and bereavement experienced by those survivors affected by service members who have died as a result of their military service in Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF). It recognizes the circumstantial and cultural factors of the death as well as the grief and trauma experiences of survivors. Resources and suggested interventions of support are highlighted.

A self-adaptive toll rate algorithm for high occupancy toll (HOT) lane operations.

Science.gov (United States)

2009-12-01

Dramatically increasing travel demands and insufficient traffic facility supplies have resulted in severe : traffic congestion. High Occupancy Toll (HOT) lane operations have been proposed as one of the most : applicable and cost-effective countermea...

Comparison of Different Toll Policies in the Dynamic Second-best Optimal Toll Design Problem : Case study on a Three-link network

NARCIS (Netherlands)

Sta?ková, K.; Olsder, J.J.; Bliemer, M.C.J.

2009-01-01

In this paper, the dynamic optimal toll design problem is considered as a one leader-many followers hierarchical non-cooperative game. On a given network the road authority as the leader tolls some links in order to reach its objective, while travelers as followers minimize their perceived travel

Cloning and Analysis of Gene Expression of Two Toll Receptors in Freshwater Pearl Mussel Hyriopsis cumingii

Directory of Open Access Journals (Sweden)

Ying Huang

2018-03-01

Full Text Available Toll receptors are involved in innate immunity of invertebrates. In this study, we identify and characterize two Toll genes (named HcToll4 and HcToll5 from triangle sail mussel Hyriopsis cumingii. HcToll4 has complete cDNA sequence of 3,162 bp and encodes a protein of 909 amino acids. HcToll5 cDNA is 4,501 bp in length and encodes a protein of 924 amino acids. Both deduced HcToll4 and HcToll5 protein contain signal peptide, extracellular leucine rich repeats (LRRs, and intracellular Toll/interleukin-1 (IL-1 receptor domains. Quantitative real-time PCR analysis revealed that HcToll4 and HcToll5 were largely distributed in the hepatopancreas and could be detected in the gills and mantle. HcToll4 and HcToll5 expression could respond to Staphylococcus aureus, Vibrio parahaemolyticus, White spot syndrome virus (WSSV or Poly I:C challenge. RNA interference by siRNA results showed that HcToll4 and HcToll5 were involved in the regulation of theromacin (HcThe and whey acidic protein (HcWAP expression. Based on these results, HcToll4 and HcToll5 might play pivotal function in H. cumingii innate immune response.

Determining the Toll and Capacity of a Highway to Be Constructed in Parallel with Subway

Directory of Open Access Journals (Sweden)

Wen-Xiang Wu

2014-01-01

Full Text Available This paper considers the problem of toll and capacity choice of a new highway with a bottleneck added onto an existing transit network under four ownership/tolling regimes: public fine toll, public flat toll, private fine toll, and private flat toll. Whenever fine toll and flat toll are imposed, in a competitive highway/transit network with constant returns to scale in road construction, an optimally designed and priced privately owned highway would produce positive net benefit justly equal to the total markup with respect to all autocommuters, whereas an optimally designed and priced publicly owned highway would lead to a deficit; that is, the toll revenues are insufficient to cover its all costs. The economic conditions to invest a new road are investigated under different ownership/tolling regimes.

DMPD: Translational mini-review series on Toll-like receptors: recent advances inunderstanding the role of Toll-like receptors in anti-viral immunity. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17223961 Translational mini-review series on Toll-like receptors: recent advances i...147(2):217-26. (.png) (.svg) (.html) (.csml) Show Translational mini-review series on Toll-like receptors: r...nity. PubmedID 17223961 Title Translational mini-review series on Toll-like receptors: recent advances inund

Mangroves protected villages and reduced death toll during Indian super cyclone.

Science.gov (United States)

Das, Saudamini; Vincent, Jeffrey R

2009-05-05

Protection against coastal disasters has been identified as an important service of mangrove ecosystems. Empirical studies on this service have been criticized, however, for using small samples and inadequately controlling for confounding factors. We used data on several hundred villages to test the impact of mangroves on human deaths during a 1999 super cyclone that struck Orissa, India. We found that villages with wider mangroves between them and the coast experienced significantly fewer deaths than ones with narrower or no mangroves. This finding was robust to the inclusion of a wide range of other variables to our statistical model, including controls for the historical extent of mangroves. Although mangroves evidently saved fewer lives than an early warning issued by the government, the retention of remaining mangroves in Orissa is economically justified even without considering the many benefits they provide to human society besides storm-protection services.

PV module mounting method and mounting assembly

Science.gov (United States)

Lenox, Carl J.S.; Johnson, Kurt M.

2013-04-23

A method for mounting PV modules to a deck includes selecting PV module layout pattern so that adjacent PV module edges are spaced apart. PV mounting and support assemblies are secured to the deck according to the layout pattern using fasteners extending into the deck. The PV modules are placed on the PV mounting and support assemblies. Retaining elements are located over and secured against the upper peripheral edge surfaces of the PV modules so to secure them to the deck with the peripheral edges of the PV modules spaced apart from the deck. In some examples a PV module mounting assembly, for use on a shingled deck, comprises flashing, a base mountable on the flashing, a deck-penetrating fastener engageable with the base and securable to the deck so to secure the flashing and the base to the shingled deck, and PV module mounting hardware securable to the base.

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

DEFF Research Database (Denmark)

Yabal, Monica; Müller, Nicole; Adler, Heiko

2014-01-01

of XIAP or deletion of its RING domain lead to excessive cell death and IL-1β secretion from dendritic cells triggered by diverse Toll-like receptor stimuli. Aberrant IL-1β secretion is TNF dependent and requires RIP3 but is independent of cIAP1/cIAP2. The observed cell death also requires TNF and RIP3...... but proceeds independently of caspase-1/caspase-11 or caspase-8 function. Loss of XIAP results in aberrantly elevated ubiquitylation of RIP1 outside of TNFR complex I. Virally infected Xiap(-/-) mice present with symptoms reminiscent of XLP-2. Our data show that XIAP controls RIP3-dependent cell death and IL-1...

DMPD: Viral recognition by Toll-like receptors. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17336545 Viral recognition by Toll-like receptors. Barton GM. Semin Immunol. 2007 F...eb;19(1):33-40. Epub 2007 Mar 2. (.png) (.svg) (.html) (.csml) Show Viral recognition by Toll-like receptors.... PubmedID 17336545 Title Viral recognition by Toll-like receptors. Authors Barton GM. Publication Semin Imm

Characteristics of the auto users and non-users of central Texas toll roads.

Science.gov (United States)

2009-08-01

As toll road usage increases to finance new road infrastructure or add capacity to existing road infrastructure, the : question of who does and does not use toll roads becomes increasingly important to toll road developers, financiers, : Traffic and ...

Cloning and characterisation of the SpToll gene from green mud crab, Scylla paramamosain.

Science.gov (United States)

Lin, Zhongyang; Qiao, Jie; Zhang, Yueling; Guo, Lingling; Huang, He; Yan, Fang; Li, Yuanyou; Wang, Xiuying

2012-05-01

Toll/Toll-like receptors (TLRs), one of the most important pattern recognition receptors (PRRs), play a crucial role in innate immune responses in both invertebrates and vertebrates. In this study, we cloned and characterised a Toll gene from Scylla paramamosain (SpToll). Bioinformatic analysis predicted that SpToll contained one open reading frame of 3018bp and encoded a single-pass transmembrane domain protein of 1005 amino acids. Further, SpToll could be clustered into one branch along with other arthropod Tolls in a phylogenetic tree. SpToll transcripts could be detected by RT-PCR from all tissues examined including the heart, gill, hepatopancreas, stomach, intestine, muscle, eyestalk and hemocytes. Infection by Vibrio parahemolyticus up-regulated SpToll mRNA expression in hemocytes after 48h. The profile of single nucleotide polymorphisms (SNPs) in the leucine-rich repeats (LRRs) domain of SpToll in three healthy crabs was then evaluated. Two hundred and twenty SNPs with a frequency of about 1.0-4.0% were identified in hemocyte DNA/cDNA. Surprisingly, the adenine to guanine transition at position 1372 (c.1372A>G) had a frequency of about 50%. Finally, the results showed that challenge with V. parahemolyticus stimulated the appearance of two sets of SNPs in crabs. More importantly, the c.1372A>G mutation could contribute to a low mortality after V. parahemolyticus infection and introduce variation of charge and secondary structure into the SpToll polypeptide. In summary, these studies suggested a novel Toll homologue in crab and identified a SNP with potential pathogen-resistant activities. The result will be important for the investigation of crab immune defense mechanisms. Copyright © 2011 Elsevier Ltd. All rights reserved.

DMPD: Endogenous ligands of Toll-like receptors. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 15178705 Endogenous ligands of Toll-like receptors. Tsan MF, Gao B. J Leukoc Biol. ...2004 Sep;76(3):514-9. Epub 2004 Jun 3. (.png) (.svg) (.html) (.csml) Show Endogenous ligands of Toll-like re...ceptors. PubmedID 15178705 Title Endogenous ligands of Toll-like receptors. Authors Tsan MF, Gao B. Publicat

Dynamically Determining the Toll Plaza Capacity by Monitoring Approaching Traffic Conditions in Real-Time

Directory of Open Access Journals (Sweden)

Cheolsun Kim

2016-03-01

Full Text Available This study presents an analytical method for dynamically adjusting toll plaza capacity to cope with a sudden shift in demand. The proposed method uses a proxy measure developed using discharge rate observed at toll plazas and segment travel times measured by probe vehicles. The effectiveness of the method has been evaluated by analyzing the empirical data obtained from toll plazas in the San Francisco Bay Area before and after toll plaza capacity changed. Findings indicate that the estimated number of vehicles stored near the upstream of toll plaza based on discharge rate and their travel times can be used as a proxy measure for predicting the effect of changes in toll plaza capacity. The proposed model can aid government agencies to dynamically adjust the toll plaza capacity in response to a sudden shift in demand due to various situations of failure.

DMPD: Toll like receptors and autoimmunity: a critical appraisal. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17959357 Toll like receptors and autoimmunity: a critical appraisal. Papadimitraki ...ml) Show Toll like receptors and autoimmunity: a critical appraisal. PubmedID 17959357 Title Toll like receptors and auto

Substantial-Motivational Mechanism for Substantiation of Tolling Operations in Conditions of the European Integration

OpenAIRE

Melnyk Olga G; Kots Iryna I.

2016-01-01

The article is concerned with conceptualization of substance, distinguishing characteristics and motives of the implementation of tolling operations in conditions of the European integration. The study, based on the systematization and analysis of existing scientific approaches to definition of essence of tolling and tolling operations, has disclosed the dominating poli-positionality and ambiguity in this area. Economical autonomy of tolling operations has been determined, t...

Deaths From Secondhand Smoke Exposure in the United States: Economic Implications

Science.gov (United States)

Sung, Hai-Yen; Shi, Yanling

2012-01-01

Objectives. We estimated the number of deaths attributable to secondhand smoke (SHS), years of potential life lost (YPLL), and value of lost productivity for different US racial/ethnic groups in 2006. Methods. We determined the number of SHS–related deaths among nonsmokers from 2 adult and 4 infant conditions using an epidemiological approach. We estimated adult SHS exposure using detectable serum cotinine. For each death, we determined the YPLL and the value of lost productivity. Results. SHS exposure resulted in more than 42 000 deaths: more than 41 000 adults and nearly 900 infants. Blacks accounted for 13% of all deaths but 24% to 36% of infant deaths. SHS–attributable deaths resulted in a loss of nearly 600 000 YPLL and $6.6 billion of lost productivity, or $158 000 per death. The value of lost productivity per death was highest among Blacks ($238 000) and Hispanics ($193 000). Conclusions. The economic toll of SHS exposure is substantial, with communities of color having the greatest losses. Interventions need to be designed to reduce the health and economic burden of smoking on smokers and nonsmokers alike and on particularly vulnerable groups. PMID:22994180

Infrared vision for the nondestructive inspection of the historic Dery Bridge toll panel

International Nuclear Information System (INIS)

Ibarra-Castanedo, C.; Cloutier, I.; Gagne, S.; Maldague, X.

2015-01-01

The Dery Gorge holds one of the first toll bridges in Quebec that was in effect from the construction of the bridge in 1804 to be finally abolished in 1910. The toll pricing was indicated on a wooden panel, which was originally installed on the bridge's toll keeper's house, In its present condition this panel shows the toll rates in French and English corresponding to the last period during which the toll was in operation (c.1860-1870), Nevertheless, some indications of older inscriptions can also be partially seen. The main goal of this work was to improve the visibility of the hidden inscriptions by exploring two infrared vision techniques: infrared reflectography and infrared thermography. (author)

Infrared vision for the nondestructive inspection of the historic Dery Bridge toll panel

Energy Technology Data Exchange (ETDEWEB)

Ibarra-Castanedo, C. [Laval Univ., Dept. of Electrical and Computer Engineering, Computer Vision and Systems Lab., Laval, Quebec (Canada); Cloutier, I.; Gagne, S. [Centre de conservation du Quebec, Quebec (Canada); Maldague, X. [Laval Univ., Dept. of Electrical and Computer Engineering, Computer Vision and Systems Lab., Laval, Quebec (Canada)

2015-03-15

The Dery Gorge holds one of the first toll bridges in Quebec that was in effect from the construction of the bridge in 1804 to be finally abolished in 1910. The toll pricing was indicated on a wooden panel, which was originally installed on the bridge's toll keeper's house, In its present condition this panel shows the toll rates in French and English corresponding to the last period during which the toll was in operation (c.1860-1870), Nevertheless, some indications of older inscriptions can also be partially seen. The main goal of this work was to improve the visibility of the hidden inscriptions by exploring two infrared vision techniques: infrared reflectography and infrared thermography. (author)

Photovoltaic mounting/demounting unit

DEFF Research Database (Denmark)

2014-01-01

The present invention relates to a photovoltaic arrangement comprising a photovoltaic assembly comprising a support structure defining a mounting surface onto which a photovoltaic module is detachably mounted; and a mounting/demounting unit comprising at least one mounting/demounting apparatus...... which when the mounting/demounting unit is moved along the mounting surface, causes the photovoltaic module to be mounted or demounted to the support structure; wherein the photovoltaic module comprises a carrier foil and wherein a total thickness of the photo voltaic module is below 500 muiotaeta....... The present invention further relates to an associated method for mounting/demounting photovoltaic modules....

Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis

Directory of Open Access Journals (Sweden)

Uddman Rolf

2005-09-01

Full Text Available Abstract Background Toll-like receptors enable the host to recognize a large number of pathogen-associated molecular patterns such as bacterial lipopolysaccharide, viral RNA, CpG-containing DNA and flagellin. Toll-like receptors have also been shown to play a pivotal role in both innate and adaptive immune responses. The role of Toll-like receptors as a primary part of our microbe defense system has been shown in several studies, but their possible function as mediators in allergy and asthma remains to be established. The present study was designed to examine the expression of Toll-like receptors 2, 3 and 4 in the nasal mucosa of patients with intermittent allergic rhinitis, focusing on changes induced by exposure to pollen. Methods 27 healthy controls and 42 patients with seasonal allergic rhinitis volunteered for the study. Nasal biopsies were obtained before and during pollen season as well as before and after allergen challenge. The seasonal material was used for mRNA quantification of Toll-like receptors 2, 3 and 4 with real-time polymerase chain reaction, whereas specimens achieved in conjunction with allergen challenge were used for immunohistochemical localization and quantification of corresponding proteins. Results mRNA and protein representing Toll-like receptors 2, 3 and 4 could be demonstrated in all specimens. An increase in protein expression for all three receptors could be seen following allergen challenge, whereas a significant increase of mRNA only could be obtained for Toll-like receptor 3 during pollen season. Conclusion The up-regulation of Toll-like receptors 2, 3 and 4 in the nasal mucosa of patients with symptomatic allergic rhinitis supports the idea of a role for Toll-like receptors in allergic airway inflammation.

Alcohol resistance in Drosophila is modulated by the Toll innate immune pathway.

Science.gov (United States)

Troutwine, B R; Ghezzi, A; Pietrzykowski, A Z; Atkinson, N S

2016-04-01

A growing body of evidence has shown that alcohol alters the activity of the innate immune system and that changes in innate immune system activity can influence alcohol-related behaviors. Here, we show that the Toll innate immune signaling pathway modulates the level of alcohol resistance in Drosophila. In humans, a low level of response to alcohol is correlated with increased risk of developing an alcohol use disorder. The Toll signaling pathway was originally discovered in, and has been extensively studied in Drosophila. The Toll pathway is a major regulator of innate immunity in Drosophila, and mammalian Toll-like receptor signaling has been implicated in alcohol responses. Here, we use Drosophila-specific genetic tools to test eight genes in the Toll signaling pathway for effects on the level of response to ethanol. We show that increasing the activity of the pathway increases ethanol resistance whereas decreasing the pathway activity reduces ethanol resistance. Furthermore, we show that gene products known to be outputs of innate immune signaling are rapidly induced following ethanol exposure. The interaction between the Toll signaling pathway and ethanol is rooted in the natural history of Drosophila melanogaster. © 2016 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.

Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

Science.gov (United States)

Dunne, Aisling; Ejdeback, Mikael; Ludidi, Phumzile L; O'Neill, Luke A J; Gay, Nicholas J

2003-10-17

The Toll/interleukin 1 receptor (TIR) domain is a region found in the cytoplasmic tails of members of the Toll-like receptor/interleukin-1 receptor superfamily. The domain is essential for signaling and is also found in the adaptor proteins Mal (MyD88 adaptor-like) and MyD88, which function to couple activation of the receptor to downstream signaling components. Experimental structures of two Toll/interleukin 1 receptor domains reveal a alpha-beta-fold similar to that of the bacterial chemotaxis protein CheY, and other evidence suggests that the adaptors can make heterotypic interactions with both the receptors and themselves. Here we show that the purified TIR domains of Mal and MyD88 can form stable heterodimers and also that Mal homodimers and oligomers are dissociated in the presence of ATP. To identify structural features that may contribute to the formation of signaling complexes, we produced models of the TIR domains from human Toll-like receptor 4 (TLR4), Mal, and MyD88. We found that although the overall fold is conserved the electrostatic surface potentials are quite distinct. Docking studies of the models suggest that Mal and MyD88 bind to different regions in TLRs 2 and 4, a finding consistent with a cooperative role of the two adaptors in signaling. Mal and MyD88 are predicted to interact at a third non-overlapping site, suggesting that the receptor and adaptors may form heterotetrameric complexes. The theoretical model of the interactions is supported by experimental data from glutathione S-transferase pull-downs and co-immunoprecipitations. Neither theoretical nor experimental data suggest a direct role for the conserved proline in the BB-loop in the association of TLR4, Mal, and MyD88. Finally we show a sequence relationship between the Drosophila protein Tube and Mal that may indicate a functional equivalence of these two adaptors in the Drosophila and vertebrate Toll pathways.

Simulation-Based Testbed Development for Analyzing Toll Impacts on Freeway Travel

Science.gov (United States)

2012-06-01

Traffic congestion has been a world-wide problem in metropolitan areas all over the world. Toll-based traffic management is one of the most applicable solutions against freeway congestion. This research chooses two toll roads, the SR-167 HOT Lane and...

DMPD: Modulation of Toll-interleukin 1 receptor mediated signaling. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 15662540 Modulation of Toll-interleukin 1 receptor mediated signaling. Li X, Qin J.... J Mol Med. 2005 Apr;83(4):258-66. Epub 2005 Jan 21. (.png) (.svg) (.html) (.csml) Show Modulation of Toll-i...nterleukin 1 receptor mediated signaling. PubmedID 15662540 Title Modulation of Toll-interleukin 1 receptor

Photovoltaic module mounting system

Science.gov (United States)

Miros, Robert H. J. [Fairfax, CA; Mittan, Margaret Birmingham [Oakland, CA; Seery, Martin N [San Rafael, CA; Holland, Rodney H [Novato, CA

2012-04-17

A solar array mounting system having unique installation, load distribution, and grounding features, and which is adaptable for mounting solar panels having no external frame. The solar array mounting system includes flexible, pedestal-style feet and structural links connected in a grid formation on the mounting surface. The photovoltaic modules are secured in place via the use of attachment clamps that grip the edge of the typically glass substrate. The panel mounting clamps are then held in place by tilt brackets and/or mid-link brackets that provide fixation for the clamps and align the solar panels at a tilt to the horizontal mounting surface. The tilt brackets are held in place atop the flexible feet and connected link members thus creating a complete mounting structure.

Magnetic core mounting system

Science.gov (United States)

Ronning, Jeffrey J.

2002-01-01

A mounting apparatus for an electromagnetic device such as a transformer of inductor includes a generally planar metallic plate as a first heat sink, and a metallic mounting cup as a second heat sink. The mounting cup includes a cavity configured to receive the electromagnetic device, the cavity being defined by a base, and an axially-extending annular sidewall extending from the base to a flange portion of the mounting cup. The mounting cup includes first and second passages for allowing the leads of first and second windings of the electromagnetic device to be routed out of the cavity. The cavity is filled with a polyurethane potting resin, and the mounting cup, including the potted electromagnetic device, is mounted to the plate heat sink using fasteners. The mounting cup, which surrounds the electromagnetic device, in combination with the potting resin provides improved thermal transfer to the plate heat sink, as well as providing resistance to vibration and shocks.

DMPD: Role of Toll-like receptor responses for sepsis pathogenesis. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 18086373 Role of Toll-like receptor responses for sepsis pathogenesis. Weighardt H,... of Toll-like receptor responses for sepsis pathogenesis. PubmedID 18086373 Title Role of Toll-like receptor... responses for sepsis pathogenesis. Authors Weighardt H, Holzmann B. Publication

GSK-3β Inhibition Attenuates LPS-Induced Death but Aggravates Radiation-Induced Death via Down-Regulation of IL-6

Directory of Open Access Journals (Sweden)

Bailong Li

2013-12-01

Full Text Available Background: Exposure of high dose ionizing radiation is lethal. Signal pathways involved in radiation biology reaction still remain illdefined. Lipopolysaccharides (LPS, the ligands of Toll-like receptor 4(TLR4, could elicit strong immune responses. Glycogen synthase kinase-3β(GSK-3β promotes the production of inflammatory molecules and cell migration. Inhibition of GSK-3β provides protection against inflammation in animal models. The aim of the study was to investigate role of GSK-3β in LPS shock and ionizing radiation. Methods: WT or IL-6-/-mice or cells were pretreated with SB216763, a GSK-3β inhibitor, and survival of the mice was determined. Cell viability was assayed by Cell Counting Kit. Apoptosis was assayed by Annexin V-PI double staining. Serum concentrations of IL-6 and TNF-α were determined by ELISA. Results: SB216763 attenuated LPS induced mice or cell death but aggravated radiation induced mice or cell death. SB216763 reduced IL-6, but not TNF-α levels in vivo. IL-6-/- mice were more resistant to LPS-induced death but less resistant to radiation-induced death than wild type mice. Conclusions: Inhibition of GSK-3β conferred resistance to LPS shock but fostered death induced by ionizing radiation. Inhibition of GSK-3β was effective by reducing IL-6.

Electronic Toll And Traffic Management Systems, National Cooperative Highway Research Program Synthesis

Science.gov (United States)

1993-01-01

ELECTRONIC TOLL COLLECTION OR ETC AND TRAFFIC MANAGEMENT OR ETTM, AUTOMATIC VEHICLE IDENTIFICATION OR AVI : ELECTRONIC TOLL COLLECTION AND TRAFFIC MANAGEMENT (ETTM) SYSTEMS ARE NOT A FUTURISTIC DREAM, THEY ARE OPERATING OR ARE BEING TESTED TODAY I...

A Cost Effective Security Technology Integrated with RFID Based Automated Toll Collection System

Directory of Open Access Journals (Sweden)

Rafiya Hossain

2017-09-01

Full Text Available Crime statistics and research on criminology show that under similar circumstances,crimes are more likely to occur in developing countries than in developed countries due to their lack ofsecurity measures. Transport crimes on highways and bridges are one of the most common crimes in the developing nations. Automation of various systems like the toll collection system is being introduced in the developing countries to avoid corruption in the collection of toll, decrease cost and increase operational efficiency. The goal of this research is to find an integrated solution that enhances security along with the advantage of automated toll collection. Inspired by the availability of many security systems, this research presents a system that can block a specific vehicle or a particular type of vehicles at the toll booths based on directives from the law enforcement agencies. The heart of the system is based on RFID (Radio Frequency Identification technology. In this system, by sending a text message the law enforcement agency or the authority that controls the toll booths can prevent the barrier from being liftedeven after deduction of the toll charge if the passing vehicle has a security issue. The designed system should help the effort of reducing transport crimes on highways and bridges of developing countries.

DMPD: Toll-like receptors regulation of viral infection and disease. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 18280610 Toll-like receptors regulation of viral infection and disease. Thompson JM...how Toll-like receptors regulation of viral infection and disease. PubmedID 18280610 Title Toll-like recepto...rs regulation of viral infection and disease. Authors Thompson JM, Iwasaki A. Pub

Risk neutral second best toll pricing.

Science.gov (United States)

2011-08-01

We propose a risk-neutral second best toll pricing scheme to account for the possible no uniqueness : of user equilibrium solutions. The scheme is designed to optimize for the expected objective value : as the UE solution varies within the solution s...

Pipelines update : new tolls and new opportunities in gas gathering

International Nuclear Information System (INIS)

Shelton, E.

1999-01-01

An overview of the new TransCanada energy transmission system was given. TransCanada has ownership interests in seven other North American natural gas pipelines and the integration of former NOVA Gas Transmission, TransCanada Energy Transmission and ANG Pipeline organizations into a single organization is nearing completion. Integration efforts have been driven by TransCanada's commitment to provide customers with lower costs and improved service levels. The service enhancements will include one-stop shopping, customer advisory councils, harmonized design criteria, optimized operations/maintenance, and consistent billing processes. The new toll design which will replace the current postage-stamp pricing regime offered by NGTL was also reviewed, emphasizing key features such as pricing, term linked tolls, interruptible/short term tolls, renewal incentive, risk/reward collar, transition period and new services

Natural Disasters, Corpses and the Risk of Infectious Diseases

Directory of Open Access Journals (Sweden)

JM Conly

2005-01-01

Full Text Available The recent occurrence of the category 4 Hurricane Katrina devastated the United States? Gulf Coast. The hurricane caused widespread destruction and flooding, and left hundreds of thousands of people homeless. The mounting death toll was reported at almost 300 deaths as of September 8, 2005 (1,2. The unfolding events and high death toll have left an unusual situation in which there are many decomposing corpses either lying on the streets or floating in the flood waters. The presence of these corpses in open settings, such as in public places and in the water that has inundated much of the city of New Orleans, naturally raises concerns about the occurrence of infectious disease epidemics (3. In the aftermath of large natural disasters, instinctive uncertainties arise among workers and the general population with respect to the appropriate handling and disposal of dead bodies and human remains. Given the recent occurrence of Hurricane Katrina as a large natural disaster and the unprecedented setting of the numerous corpses requiring disposal, it was considered timely to review the infectious disease risks associated with the handling of dead bodies.

DMPD: The Toll-like receptors: analysis by forward genetic methods. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 16001129 The Toll-like receptors: analysis by forward genetic methods. Beutler B. I...mmunogenetics. 2005 Jul;57(6):385-92. (.png) (.svg) (.html) (.csml) Show The Toll-like receptors: analysis by forwar...d genetic methods. PubmedID 16001129 Title The Toll-like receptors: analysis by forward genetic meth

Optoelectronic Mounting Structure

Science.gov (United States)

Anderson, Gene R.; Armendariz, Marcelino G.; Baca, Johnny R. F.; Bryan, Robert P.; Carson, Richard F.; Chu, Dahwey; Duckett, III, Edwin B.; McCormick, Frederick B.; Peterson, David W.; Peterson, Gary D.; Reber, Cathleen A.; Reysen, Bill H.

2004-10-05

An optoelectronic mounting structure is provided that may be used in conjunction with an optical transmitter, receiver or transceiver module. The mounting structure may be a flexible printed circuit board. Thermal vias or heat pipes in the head region may transmit heat from the mounting structure to the heat spreader. The heat spreader may provide mechanical rigidity or stiffness to the heat region. In another embodiment, an electrical contact and ground plane may pass along a surface of the head region so as to provide an electrical contact path to the optoelectronic devices and limit electromagnetic interference. In yet another embodiment, a window may be formed in the head region of the mounting structure so as to provide access to the heat spreader. Optoelectronic devices may be adapted to the heat spreader in such a manner that the devices are accessible through the window in the mounting structure.

Expressions of toll-like receptors 2 and 4, and relative cellular ...

African Journals Online (AJOL)

Purpose: To investigate the expressions of toll-like receptor 2 (TLR2), toll-like receptor 4 (TLR4), tumor necrosis factor alpha (TNF-α), IFN-γ (IFN- gamma), interleukin 2 (IL-2), interleukin 6 (IL-6) and interleukin 10 (IL-10) in human immunodeficiency virus (HIV) patients with tuberculosis (TB) infection. Methods: Two groups of ...

FLOW PATTERNS OF VEHICULAR TRAFFIC ALONG HIGHWAY TOLL PLAZA IN OGUN STATE

Directory of Open Access Journals (Sweden)

Bashiru A. Raji

2009-06-01

Full Text Available Congestion on our highways, freeways and arterials are increasing at an alarming rate. This occurs because there is an increase in vehicular growth without a corresponding increase in road size, and this has made free flow of traffic a preponderant problem in our highways. Toll plaza causes delay on our highways and results are formation of queue. This paper examined how simple queuing model can be used to determine traffic intensity and the flow pattern of car traffic at a toll plaza. The study was carried out with twelve field assistants at Ogere toll plaza in Ogun State. Findings show a significant variation in the degree of hourly traffic intensities at the four pay points for cars at the toll plaza. However, variation in the daily traffic intensities at the four pay points for cars showed no significant variation. The study also revealed that bumps constructed to check vehicles speed, hawker’s trading activities are among other factors that constitute hindrance to free flow of traffic other than service time and inter-arrival time of cars at the toll plaza. It is therefore recommended that appropriate authority should look into these factors and take necessary steps towards ensuring free flow of traffic at the plaza.

DMPD: Proximal effects of Toll-like receptor activation in dendritic cells. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17142025 Proximal effects of Toll-like receptor activation in dendritic cells. Watt...) (.svg) (.html) (.csml) Show Proximal effects of Toll-like receptor activation in dendritic cells. PubmedID... 17142025 Title Proximal effects of Toll-like receptor activation in dendritic ce

Liner mounting assembly

Science.gov (United States)

Halila, Ely E. (Inventor)

1994-01-01

A mounting assembly includes an annular supporting flange disposed coaxially about a centerline axis which has a plurality of circumferentially spaced apart supporting holes therethrough. An annular liner is disposed coaxially with the supporting flange and includes a plurality of circumferentially spaced apart mounting holes aligned with respective ones of the supporting holes. Each of a plurality of mounting pins includes a proximal end fixedly joined to the supporting flange through a respective one of the supporting holes, and a distal end disposed through a respective one of the liner mounting holes for supporting the liner to the supporting flange while unrestrained differential thermal movement of the liner relative to the supporting flange.

DMPD: All is not Toll: new pathways in DNA recognition. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 16446382 All is not Toll: new pathways in DNA recognition. Wagner H, Bauer S. J Exp... Med. 2006 Feb 20;203(2):265-8. Epub 2006 Jan 30. (.png) (.svg) (.html) (.csml) Show All is not Toll: new pathways in DNA recognition.... PubmedID 16446382 Title All is not Toll: new pathways in DNA recognition. Authors

DMPD: The negative regulation of Toll-like receptor and associated pathways. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17621314 The negative regulation of Toll-like receptor and associated pathways. Lan...) Show The negative regulation of Toll-like receptor and associated pathways. PubmedID 17621314 Title The ne...gative regulation of Toll-like receptor and associated pathways. Authors Lang T,

Increased Male-Male Mounting Behaviour in Desert Locusts during Infection with an Entomopathogenic Fungus.

Science.gov (United States)

Clancy, Lisa M; Cooper, Amy L; Griffith, Gareth W; Santer, Roger D

2017-07-18

Same-sex sexual behaviour occurs across diverse animal taxa, but adaptive explanations can be difficult to determine. Here we investigate male-male mounting (MMM) behaviour in female-deprived desert locust males infected with the entomopathogenic fungus Metarhizium acridum. Over a four-week period, infected locusts performed more MMM behaviours than healthy controls. Among infected locusts, the probability of MMM, and the duration of time spent MMM, significantly increased with the mounting locust's proximity to death. In experimental trials, infected locusts were also significantly more likely than controls to attempt to mount healthy males. Therefore, we demonstrate that MMM is more frequent among infected than healthy male locusts, and propose that this may be explained by terminal reproductive effort and a lowered mate acceptance threshold in infected males. However, during experimental trials mounting attempts were more likely to be successful if the mounted locusts were experimentally manipulated to have a reduced capacity to escape. Thus, reduced escape capability resulting from infection may also contribute to the higher frequency of MMM among infected male locusts. Our data demonstrate that pathogen infection can affect same-sex sexual behaviour, and suggest that the impact of such behaviours on host and pathogen fitness will be a novel focus for future research.

Simultaneous Optimization of Road Tolls and Tradable Credits in Public-private Mixed Networks

Directory of Open Access Journals (Sweden)

Nan Jiang

2017-12-01

Full Text Available This paper investigates a hybrid management policy of road tolls and tradable credits in mixed road networks with both public and private roads. In the public sub-network, a tradable credit scheme is applied to mitigate traffic congestion. In the private sub-network, tolls are collected by the private company, but the toll levels and toll locations are determined by the government. The purpose of toll charge is two-fold: on the one hand, the government uses it as a tool for mitigating congestion; on the other hand, a threshold of revenue should be guaranteed for the profitability of the private company. A bi-level programming model is formulated to minimize the total travel time in the network by taking into account the user equilibrium travel behaviour and the revenue requirement of private firms. To obtain a  global optimum solution, the bi-level model is transformed into an equivalent single-level mixed integer linear program that can be easily solved with commercial software. Numerical examples are provided to demonstrate the effectiveness of the developed model and the efficiency of the proposed algorithm. It is shown that the mixed management schemes can achieve favourable targets, namely, joint implementation of road tolls and tradable credits can effectively mitigate traffic congestion and meanwhile maintain reasonable revenue for the private company.

Developing Road Infrastructure Route Planning: Increasing Feasibility of Toll Road Project

Directory of Open Access Journals (Sweden)

Mohammed Ali Berawi

2016-12-01

Full Text Available Indonesian government attempts to improve connectivity and to increase regional activities in SumateraIsland through the development of Trans Sumatera Toll Road (TSTR.However, despite its benefits to local economic development in Sumatera, the project shows low feasibility due to a low amount of investment. It can be attributed from the lack of planning in the initial phase to produce a comprehensive route that considers the various potentials of the regions. Thus, this research aims to investigate alternative routeplanning of Trans Sumatera Toll Road particularly in this paper for Central Sumatera by studying Gross Regional Domestic Product (GRDP, population and other significant factors. This research exposes cities and districts in Riau, West Sumatera, and Jambi which potentially contribute to the regional economy. Each selected towns and districts will be integrated with the intermodal system and connected to other functions to establish the Trans Sumatera Toll Roadproject in Central Sumatera. Compared to existing estimation of investment from public records, this alternative route has generated a competitive cost of investment which is estimated around 118,053,400,074,696 rupiahs. The research findings are expected to become the basis to improve other similar infrastructure toll road project development.

Simulation of investment returns of toll projects.

Science.gov (United States)

2013-08-01

This research develops a methodological framework to illustrate key stages in applying the simulation of investment returns of toll projects, acting as an example process of helping agencies conduct numerical risk analysis by taking certain uncertain...

The evaluation model of the design of toll

Science.gov (United States)

Feng, Shuting

2018-04-01

In recent years, the dramatic increase in traffic burden has highlighted the necessity of rational allocation of toll plaza. At the same time, the need to consider a lot of factors has enhanced the design requirements. In this background, we carry out research on this subject. We propose a reasonable assumption, and abstract the toll plaza into a model only related to B and L. By using the queuing theory and traffic flow theory, we define the throughput, cost and accident prevent with B and L to acquire the base model. By using the method of linear weighting in economics to calculate this model, the optimal B and L strategies are obtained.

DMPD: Toll-like receptors and Type I interferons. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available m. 2007 May 25;282(21):15319-23. Epub 2007 Mar 29. (.png) (.svg) (.html) (.csml) Show Toll-like receptors and Type I interferons. Pub...medID 17395581 Title Toll-like receptors and Type I interferons. Authors Uematsu S,

DMPD: Toll-like receptors: novel pharmacological targets for the treatment ofneurological diseases. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17974478 Toll-like receptors: novel pharmacological targets for the treatment ofneu...png) (.svg) (.html) (.csml) Show Toll-like receptors: novel pharmacological targets for the treatment ofneur...ological diseases. PubmedID 17974478 Title Toll-like receptors: novel pharmacological target

DMPD: Innate immunity and toll-like receptors: clinical implications of basic scienceresearch. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 15069387 Innate immunity and toll-like receptors: clinical implications of basic science...te immunity and toll-like receptors: clinical implications of basic scienceresearch. PubmedID 15069387 Title... Innate immunity and toll-like receptors: clinical implications of basic sciencer

Commentary: Pursuing justice in death penalty trials.

Science.gov (United States)

Watson, Clarence; Eth, Spencer; Leong, Gregory B

2012-01-01

The capital trial, by its nature, is fraught with emotionally disturbing elements that jurors must face when deciding the ultimate fate of a guilty defendant. A confluence of mitigating and aggravating factors influences a capital jury's decision to impose a sentence of death. The presence or absence of defendant remorse in these cases may make all the difference in whether a capital defendant's life is spared. This commentary examines the onerous emotional toll encountered by capital jurors in light of the findings of Corwin and colleagues regarding defendant remorse and juror's need for affect. The commentary also presents practical and ethics-related considerations that should be kept in mind when reflecting on their study.

The Emotional Toll of Long-Term Unemployment: Examining the Interaction Effects of Gender and Marital Status

Directory of Open Access Journals (Sweden)

Gokce Basbug

2017-04-01

Full Text Available Prior research shows that long-term unemployment (LTU generates a negative emotional toll but leaves unexplored how such toll varies by gender and marital status. Using a mixed-methods approach we examine how the negative emotional toll of LTU is shaped by the interaction of gender and marital status. Our qualitative findings suggest that more unemployed married men than women experience marital tensions that exacerbate the emotional toll of unemployment. Our analysis of survey data show that while marriages improve the well-being of both unemployed men and women, for married men but not women such benefits disappear once we control for household income. These findings contribute to the existing literature by deepening our understanding of how gender and marital status mediate the emotional toll of LTU.

The relationship between emotional labor status and workplace violence among toll collectors.

Science.gov (United States)

Joo, Yosub; Rhie, Jeongbae

2017-01-01

This study aimed to identify the emotional labor and workplace violence status among toll collectors by assessing and comparing the same with that in workers in other service occupation. It also aimed to analyze the relationship between emotional labor and workplace violence. This study examined emotional labor and workplace violence status in 264 female toll collectors from August 20 to September 4, 2015. The emotional labor was assessed using the Korean Emotional Labor Scale (K-ELS), and a questionnaire was used to examine the presence or absence, and type and frequency of workplace violence experienced by the subjects. A linear regression analysis was also performed to analyze the relationship between workplace violence and emotional labor. The scores on "emotional demanding and regulation ( p  workplace violence, whereas they were "normal" of emotional labor in those who did not. Even after being adjusted in the linear regression analysis, the emotional labor scores for the above 4 sub-categories were still significantly high in those who experienced workplace violence. On comparing the present scores with 13 other service occupations, it was found that toll collectors had the highest level in "emotional disharmony and hurt," "organizational surveillance and monitoring," and "organizational supportive and protective system". This study found that the toll collectors engaged in a high level of emotional labor. Additionally, there was a significant relationship between emotional labor and the experience of workplace violence among the toll collectors.

The Aedes aegypti toll pathway controls dengue virus infection.

Directory of Open Access Journals (Sweden)

Zhiyong Xi

2008-07-01

Full Text Available Aedes aegypti, the mosquito vector of dengue viruses, utilizes its innate immune system to ward off a variety of pathogens, some of which can cause disease in humans. To date, the features of insects' innate immune defenses against viruses have mainly been studied in the fruit fly Drosophila melanogaster, which appears to utilize different immune pathways against different types of viruses, in addition to an RNA interference-based defense system. We have used the recently released whole-genome sequence of the Ae. aegypti mosquito, in combination with high-throughput gene expression and RNA interference (RNAi-based reverse genetic analyses, to characterize its response to dengue virus infection in different body compartments. We have further addressed the impact of the mosquito's endogenous microbial flora on virus infection. Our findings indicate a significant role for the Toll pathway in regulating resistance to dengue virus, as indicated by an infection-responsive regulation and functional assessment of several Toll pathway-associated genes. We have also shown that the mosquito's natural microbiota play a role in modulating the dengue virus infection, possibly through basal-level stimulation of the Toll immune pathway.

Shoulder-Mounted Robot for MRI-guided arthrography: Accuracy and mounting study.

Science.gov (United States)

Monfaredi, R; Wilson, E; Sze, R; Sharma, K; Azizi, B; Iordachita, I; Cleary, K

2015-08-01

A new version of our compact and lightweight patient-mounted MRI-compatible 4 degree-of-freedom (DOF) robot for MRI-guided arthrography procedures is introduced. This robot could convert the traditional two-stage arthrography procedure (fluoroscopy-guided needle insertion followed by a diagnostic MRI scan) to a one-stage procedure, all in the MRI suite. The results of a recent accuracy study are reported. A new mounting technique is proposed and the mounting stability is investigated using optical and electromagnetic tracking on an anthropomorphic phantom. Five volunteer subjects including 2 radiologists were asked to conduct needle insertion in 4 different random positions and orientations within the robot's workspace and the displacement of the base of the robot was investigated during robot motion and needle insertion. Experimental results show that the proposed mounting method is stable and promising for clinical application.

DMPD: Toll-like receptors: paving the path to T cell-driven autoimmunity? [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17888644 Toll-like receptors: paving the path to T cell-driven autoimmunity? Marsla... Toll-like receptors: paving the path to T cell-driven autoimmunity? PubmedID 17888644 Title Toll-like recep...tors: paving the path to T cell-driven autoimmunity? Authors Marsland BJ, Kopf M.

How a fast lane may replace a congestion toll

DEFF Research Database (Denmark)

Fosgerau, Mogens

2011-01-01

This paper considers a congested bottleneck. A fast lane reserves a more than proportional share of capacity to a designated group of travellers. Travellers are otherwise identical and other travellers can use the reserved capacity when it would otherwise be idle. The paper shows that such a fast...... welfare improving when demand is elastic....... lane is always Pareto improving under Nash equilibrium in arrival times at the bottleneck and inelastic demand. It can replicate the arrival schedule and queueing outcomes of a toll that optimally charges a constant toll during part of the demand peak. Within some bounds, the fast lane scheme is still...

How a fast lane may replace a congestion toll

DEFF Research Database (Denmark)

Fosgerau, Mogens

This paper considers a congested bottleneck. A fast lane reserves a more than proportional share of capacity to a designated group of travellers. Travellers are otherwise identical and other travellers can use the reserved capacity when it would otherwise be idle. The paper shows that such a fast...... welfare improving when demand is elastic....... lane is always Pareto improving under Nash equilibrium in arrival times at the bottleneck and inelastic demand. It can replicate the arrival schedule and queueing outcomes of a toll that optimally charges a constant toll during part of the demand peak. Within some bounds, the fast lane scheme is still...

Stimulation of the innate immune system of carp: role of Toll-like receptors

NARCIS (Netherlands)

Pietretti, D.

2013-01-01

Toll-like receptors (TLRs), named after the Toll gene identified in fruit flies, are a family of evolutionary conserved proteins that play a key role in the innate immune system. TLRs are found inside or on the surface of immune cells of virtually all-living animals and recognize integral parts

Disseminated cysticercosis: clinical spectrum, Toll-like receptor-4 gene polymorphisms and role of albendazole: A prospective follow-up of 60 cases with a review of 56 published cases.

Science.gov (United States)

Qavi, Abdul; Garg, Ravindra Kumar; Malhotra, Hardeep Singh; Jain, Amita; Kumar, Neeraj; Malhotra, Kiran Preet; Srivastava, Pradeep Kumar; Verma, Rajesh; Sharma, Praveen Kumar

2016-09-01

In this study, we describe clinical and imaging spectrum, and the natural course of patients with disseminated cysticercosis. How albendazole affects the course of disease has also been evaluated. We assessed the Toll-like receptor-4 gene polymorphisms, to know the reason for the apparently higher prevalence of disseminated cysticercosis in India.Sixty consecutive patients with disseminated cysticercosis were enrolled. Sixty age-and-sex-matched healthy controls were also enrolled for the purpose of genetic study. Twenty patients, who gave consent, were treated with albendazole along with corticosteroids. Forty patients did not give consent for antiparasitic therapy. Assessment for Toll-like receptor-4 gene polymorphisms (Asp299Gly and Thr399Ile genes) was done. Patients were followed for 6 months. We also performed a literature search of cases published in English language using PubMed electronic database and analyzed 56 cases thus available.There was an increased risk (6.63 fold and 4.61 fold) of disseminated cysticercosis in the presence of Asp299Gly and Thr399Ile polymorphisms in Toll-like receptor-4, respectively. The allelic frequency of Gly (11% vs. 3%, P = 0.024, odds ratio [OR] = 3.52) and Ile alleles (11% vs. 2%, P = 0.009, OR = 4.738) in disseminated cysticercosis was high. Albendazole resulted in complete disappearance of all cerebral lesions in 35% (7/20) patients and reduction in lesion load in remaining 65% (13/20) patients. No significant change in number of cysticercal lesion was noted in patients who did not receive albendazole. No major adverse reaction following antiparasitic treatment was noted. Three deaths were recorded in patients who did not receive antiparasitic treatment.Of the 56 cases reported in PubMed, 33 patients received antiparasitic treatment with follow-up data available for 31 patients. Most (24) of these patients received albendazole. A significant clinical and/or imaging improvements, on follow up, were observed in 27 patients

Analysis of adjusting effects of mounting force on frequency conversion of mounted nonlinear optics.

Science.gov (United States)

Su, Ruifeng; Liu, Haitao; Liang, Yingchun; Lu, Lihua

2014-01-10

Motivated by the need to increase the second harmonic generation (SHG) efficiency of nonlinear optics with large apertures, a novel mounting configuration with active adjusting function on the SHG efficiency is proposed and mechanically and optically studied. The adjusting effects of the mounting force on the distortion and stress are analyzed by the finite element methods (FEM), as well as the contribution of the distortion and stress to the change in phase mismatch, and the SHG efficiency are theoretically stated. Further on, the SHG efficiency is calculated as a function of the mounting force. The changing trends of the distortion, stress, and the SHG efficiency with the varying mounting force are obtained, and the optimal ones are figured out. Moreover, the mechanism of the occurrence of the optimal values is studied and the adjusting strategy is put forward. Numerical results show the robust adjustment of the mounting force, as well as the effectiveness of the mounting configuration, in increasing the SHG efficiency.

DMPD: Toll-like receptor 9 in murine lupus: more friend than foe! [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 18241699 Toll-like receptor 9 in murine lupus: more friend than foe! Yu P, Musette ...us: more friend than foe! PubmedID 18241699 Title Toll-like receptor 9 in murine lupus...P, Peng SL. Immunobiology. 2008;213(2):151-7. Epub 2007 Sep 21. (.png) (.svg) (.html) (.csml) Show Toll-like receptor 9 in murine lup

Classification of busses and lorries in an automatic road toll system

OpenAIRE

Jarl, Adam

2003-01-01

An automatic road toll system enables the passing vehicles to change lanes and no stop is needed for payment. Because of different weight of personal cars, busses, lorries (trucks) and other vehicles, they affect the road in different ways. It is of interest to categorize the vehicles into different classes depending of their weight so that the right fee can be set. An automatic road toll system developed by Combitech Traffic Systems AB (now Kapsch TrafficCom AB), Joenkoping, Sweden, classifi...

DMPD: Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17667936 Structure, function and regulation of the Toll/IL-1 receptor adaptor prote... (.svg) (.html) (.csml) Show Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins. ...PubmedID 17667936 Title Structure, function and regulation of the Toll/IL-1 recep

DMPD: The role of Toll-like receptors and Nod proteins in bacterial infection. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 15476921 The role of Toll-like receptors and Nod proteins in bacterial infection. P...of Toll-like receptors and Nod proteins in bacterial infection. PubmedID 15476921 Title The role of Toll-like receptors and Nod prote...ins in bacterial infection. Authors Philpott DJ, Girardi

Consumer Experiences Calling Toll-Free Corporate Hotlines.

Science.gov (United States)

Martin, Charles L.; Smart, Denise T.

1994-01-01

Finds that dimensions that contribute to caller satisfaction (of toll-free corporate hotlines) included operator characteristics such as knowledge, courtesy, and interest; specific behaviors such as apologizing for a problem, thanking the consumer for calling, and encouraging them to call again; and reducing time placed on "hold." (SR)

Nuclear DAMP complex-mediated RAGE-dependent macrophage cell death

Energy Technology Data Exchange (ETDEWEB)

Chen, Ruochan [Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213 (United States); Department of Infectious Diseases and State Key Lab of Viral Hepatitis, Xiangya Hospital, Central South University, Changsha, Hunan 410008 (China); Fu, Sha; Fan, Xue-Gong [Department of Infectious Diseases and State Key Lab of Viral Hepatitis, Xiangya Hospital, Central South University, Changsha, Hunan 410008 (China); Lotze, Michael T.; Zeh, Herbert J. [Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213 (United States); Tang, Daolin, E-mail: tangd2@upmc.edu [Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213 (United States); Kang, Rui, E-mail: kangr@upmc.edu [Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213 (United States)

2015-03-13

High mobility group box 1 (HMGB1), histone, and DNA are essential nuclear components involved in the regulation of chromosome structure and function. In addition to their nuclear function, these molecules act as damage-associated molecular patterns (DAMPs) alone or together when released extracellularly. The synergistic effect of these nuclear DNA-HMGB1-histone complexes as DAMP complexes (nDCs) on immune cells remains largely unexplored. Here, we demonstrate that nDCs limit survival of macrophages (e.g., RAW264.7 and peritoneal macrophages) but not cancer cells (e.g., HCT116, HepG2 and Hepa1-6). nDCs promote production of inflammatory tumor necrosis factor α (TNFα) release, triggering reactive oxygen species-dependent apoptosis and necrosis. Moreover, the receptor for advanced glycation end products (RAGE), but not toll-like receptor (TLR)-4 and TLR-2, was required for Akt-dependent TNFα release and subsequent cell death following treatment with nDCs. Genetic depletion of RAGE by RNAi, antioxidant N-Acetyl-L-cysteine, and TNFα neutralizing antibody significantly attenuated nDC-induced cell death. These findings provide evidence supporting novel signaling mechanisms linking nDCs and inflammation in macrophage cell death. - Highlights: • Nuclear DAMP complexes (nDCs) selectively induce cell death in macrophages, but not cancer cells. • TNFα-mediated oxidative stress is required for nDC-induced death. • RAGE-mediated Akt activation is required for nDC-induced TNFα release. • Blocking RAGE and TNFα inhibits nDC-induced macrophage cell death.

A dynamic feedback-control toll pricing methodology : a case study on Interstate 95 managed lanes.

Science.gov (United States)

2013-06-01

Recently, congestion pricing emerged as a cost-effective and efficient strategy to mitigate the congestion problem on freeways. This study develops a feedback-control based dynamic toll approach to formulate and solve for optimal tolls. The study com...

Energetics of Endotoxin Recognition in the Toll-Like Receptor 4 Innate Immune Response.

Science.gov (United States)

Paramo, Teresa; Tomasio, Susana M; Irvine, Kate L; Bryant, Clare E; Bond, Peter J

2015-12-09

Bacterial outer membrane lipopolysaccharide (LPS) potently stimulates the mammalian innate immune system, and can lead to sepsis, the primary cause of death from infections. LPS is sensed by Toll-like receptor 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variations in LPS can profoundly modulate the response. To better understand the mechanism of LPS-induced stimulation and bacterial evasion, we have calculated the binding affinity to MD-2 of agonistic and antagonistic LPS variants including lipid A, lipid IVa, and synthetic antagonist Eritoran, and provide evidence that the coreceptor is a molecular switch that undergoes ligand-induced conformational changes to appropriately activate or inhibit the receptor complex. The plasticity of the coreceptor binding cavity is shown to be essential for distinguishing between ligands, whilst similar calculations for a model bacterial LPS bilayer reveal the "membrane-like" nature of the protein cavity. The ability to predict the activity of LPS variants should facilitate the rational design of TLR4 therapeutics.

Mounting for ceramic scroll

Science.gov (United States)

Petty, Jack D.

1993-01-01

A mounting for a ceramic scroll on a metal engine block of a gas turbine engine includes a first ceramic ring and a pair of cross key connections between the first ceramic ring, the ceramic scroll, and the engine block. The cross key connections support the scroll on the engine block independent of relative radial thermal growth and for bodily movement toward an annular mounting shoulder on the engine. The scroll has an uninterrupted annular shoulder facing the mounting shoulder on the engine block. A second ceramic ring is captured between mounting shoulder and the uninterrupted shoulder on the scroll when the latter is bodily shifted toward the mouting shoulder to define a gas seal between the scroll and the engine block.

Solar panel truss mounting systems and methods

Energy Technology Data Exchange (ETDEWEB)

Al-Haddad, Tristan Farris; Cavieres, Andres; Gentry, Russell; Goodman, Joseph; Nolan, Wade; Pitelka, Taylor; Rahimzadeh, Keyan; Brooks, Bradley; Lohr, Joshua; Crooks, Ryan; Porges, Jamie; Rubin, Daniel

2016-06-28

An exemplary embodiment of the present invention provides a solar panel truss mounting system comprising a base and a truss assembly coupled to the base. The truss assembly comprises a first panel rail mount, second panel rail mount parallel to the first panel rail mount, base rail mount parallel to the first and second panel rail mounts, and a plurality of support members. A first portion of the plurality of support members extends between the first and second panel rail mounts. A second portion of the plurality of support members extends between the first panel rail mount and the base rail mount. A third portion of the plurality of support members extends between the second panel rail mount and the base rail mount. The system can further comprise a plurality of connectors for coupling a plurality of photovoltaic solar panels to the truss assembly.

Solar panel truss mounting systems and methods

Energy Technology Data Exchange (ETDEWEB)

Al-Haddad, Tristan Farris; Cavieres, Andres; Gentry, Russell; Goodman, Joseph; Nolan, Wade; Pitelka, Taylor; Rahimzadeh, Keyan; Brooks, Bradley; Lohr, Joshua; Crooks, Ryan; Porges, Jamie; Rubin, Daniel

2018-01-30

An exemplary embodiment of the present invention provides a solar panel truss mounting system comprising a base and a truss assembly coupled to the base. The truss assembly comprises a first panel rail mount, second panel rail mount parallel to the first panel rail mount, base rail mount parallel to the first and second panel rail mounts, and a plurality of support members. A first portion of the plurality of support members extends between the first and second panel rail mounts. A second portion of the plurality of support members extends between the first panel rail mount and the base rail mount. A third portion of the plurality of support members extends between the second panel rail mount and the base rail mount. The system can further comprise a plurality of connectors for coupling a plurality of photovoltaic solar panels to the truss assembly.

Solar panel truss mounting systems and methods

Science.gov (United States)

Al-Haddad, Tristan Farris; Cavieres, Andres; Gentry, Russell; Goodman, Joseph; Nolan, Wade; Pitelka, Taylor; Rahimzadeh, Keyan; Brooks, Bradley; Lohr, Joshua; Crooks, Ryan; Porges, Jamie; Rubin, Daniel

2015-10-20

An exemplary embodiment of the present invention provides a solar panel truss mounting system comprising a base and a truss assembly coupled to the base. The truss assembly comprises a first panel rail mount, second panel rail mount parallel to the first panel rail mount, base rail mount parallel to the first and second panel rail mounts, and a plurality of support members. A first portion of the plurality of support members extends between the first and second panel rail mounts. A second portion of the plurality of support members extends between the first panel rail mount and the base rail mount. A third portion of the plurality of support members extends between the second panel rail mount and the base rail mount. The system can further comprise a plurality of connectors for coupling a plurality of photovoltaic solar panels to the truss assembly.

Current Views of Toll-Like Receptor Signaling Pathways

Directory of Open Access Journals (Sweden)

Masahiro Yamamoto

2010-01-01

Full Text Available On microbial invasion, the host immediately evokes innate immune responses. Recent studies have demonstrated that Toll-like receptors (TLRs play crucial roles in innate responses that lead not only to the clearance of pathogens but also to the efficient establishment of acquired immunity by directly detecting molecules from microbes. In terms of intracellular TLR-mediated signaling pathways, cytoplasmic adaptor molecules containing Toll/IL-1R (TIR domains play important roles in inflammatory immune responses through the production of proinflammatory cytokines, nitric oxide, and type I interferon, and upregulation of costimulatory molecules. In this paper, we will describe our current understanding of the relationship between TLRs and their ligands derived from pathogens such as viruses, bacteria, fungi, and parasites. Moreover, we will review the historical and current literature to describe the mechanisms behind TLR-mediated activation of innate immune responses.

PcToll2 positively regulates the expression of antimicrobial peptides by promoting PcATF4 translocation into the nucleus.

Science.gov (United States)

Lan, Jiang-Feng; Zhao, Li-Juan; Wei, Shun; Wang, Yuan; Lin, Li; Li, Xin-Cang

2016-11-01

Drosophila Toll and mammalian Toll-like receptors (TLRs) are a family of evolutionarily conserved immune receptors that play a crucial role in the first-line defense against intruded pathogens. Activating transcription factor 4 (ATF4), a member of the ATF/CREB transcription factor family, is an important factor that participates in TLR signaling and other physiological processes. However, in crustaceans, whether ATF4 homologs were involved in TLR signaling remains unclear. In the current study, we identified a Toll homolog PcToll2 and a novel ATF4 homolog PcATF4 from Procambarus clarkii, and analyzed the likely regulatory activity of PcATF4 in PcToll2 signaling. The complete cDNA sequence of PcToll2 was 4175 bp long containing an open reading frame of 2820 bp encoding a 939-amino acid protein, and the cDNA sequence of PcATF4 was 2027 bp long with an open reading frame of 1296 bp encoding a 431-amino acid protein. PcToll2 and human TLR4 shared the high identity and they were grouped into a cluster. Furthermore, PcToll2 had a close relationship with other shrimp TLRs that possessed potential antibacterial activity. PcToll2 was highly expressed in the hemocytes, heart and gills, while PcATF4 mainly distributed in gills. Upon challenge with Vibrio parahemolyticus, PcToll2 and PcATF4 together with the antimicrobial peptides of ALF1 and ALF2 were significantly up-regulated in the hemocytes, and the PcATF4 was translocated into the nucleus. After PcToll2 silencing and challenge with Vibrio, the translocation of PcATF4 into the nucleus was inhibited and the expression of ALF1 and ALF2 was reduced, but the expression of PcDorsal and PcSTAT was not affected. Furthermore, after PcATF4 knockdown and challenge with or without Vibrio, the expression of ALF1 and ALF2 was also decreased while the expression of PcToll2 was upregulated. These results suggested that PcToll2 might regulate the expression of ALF1 and ALF2 by promoting the import of PcATF4, instead of the routine

The head-mounted microscope.

Science.gov (United States)

Chen, Ting; Dailey, Seth H; Naze, Sawyer A; Jiang, Jack J

2012-04-01

Microsurgical equipment has greatly advanced since the inception of the microscope into the operating room. These advancements have allowed for superior surgical precision and better post-operative results. This study focuses on the use of the Leica HM500 head-mounted microscope for the operating phonosurgeon. The head-mounted microscope has an optical zoom from 2× to 9× and provides a working distance from 300 mm to 700 mm. The headpiece, with its articulated eyepieces, adjusts easily to head shape and circumference, and offers a focus function, which is either automatic or manually controlled. We performed five microlaryngoscopic operations utilizing the head-mounted microscope with successful results. By creating a more ergonomically favorable operating posture, a surgeon may be able to obtain greater precision and success in phonomicrosurgery. Phonomicrosurgery requires the precise manipulation of long-handled cantilevered instruments through the narrow bore of a laryngoscope. The head-mounted microscope shortens the working distance compared with a stand microscope, thereby increasing arm stability, which may improve surgical precision. Also, the head-mounted design permits flexibility in head position, enabling operator comfort, and delaying musculoskeletal fatigue. A head-mounted microscope decreases the working distance and provides better ergonomics in laryngoscopic microsurgery. These advances provide the potential to promote precision in phonomicrosurgery. Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.

Channel uranium-graphite reactor mounting

International Nuclear Information System (INIS)

Polushkin, K.K.; Kuznetsov, A.G.; Zheleznyakov, B.N.

1981-01-01

According to theoretical principles of general engineering technology the engineering experience of construction-mounting works at the NPP with channel uranium-graphite reactors is systematized. Main parameters and structural features of the 1000 MW channel uranium-graphite reactors are considered. The succession of mounting operations, premounting equipment and pipelines preparation and mounting works technique are described. The most efficient methods of fitting, welding and machining of reactor elements are recommended. Main problems of technical control service are discussed. A typical netted diagram of main equipment of channel uranium-graphite reactors mounting is given

Toll-Like Receptor-3 and Geographic Atrophy in Age-Related Macular Degeneration

Science.gov (United States)

Yang, Zhenglin; Stratton, Charity; Francis, Peter J.; Kleinman, Mark E.; Tan, Perciliz L.; Gibbs, Daniel; Tong, Zongzhong; Chen, Haoyu; Constantine, Ryan; Yang, Xian; Chen, Yuhong; Zeng, Jiexi; Davey, Lisa; Ma, Xiang; Hau, Vincent S.; Wang, Chi; Harmon, Jennifer; Buehler, Jeanette; Pearson, Erik; Patel, Shrena; Kaminoh, Yuuki; Watkins, Scott; Luo, Ling; Zabriskie, Norman A.; Bernstein, Paul S.; Cho, Wongil; Schwager, Andrea; Hinton, David R; Klein, Michael L; Hamon, Sara C.; Simmons, Emily; Yu, Beifeng; Campochiaro, Betsy; Sunness, Janet S.; Campochiaro, Peter; Jorde, Lynn; Parmigiani, Giovanni; Zack, Donald J.; Katsanis, Nicholas; Ambati, Jayakrishna; Zhang, Kang

2008-01-01

BACKGROUND Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment in the developed world. Advanced AMD is comprised of geographic atrophy (GA) and choroidal neovascularization (CNV). Specific genetic variants that predispose for GA are largely unknown. METHODS We tested (i) for association between the functional toll-like receptor-3 (TLR3) variant rs3775291 (L412F) and AMD in European Americans and (ii) the effect of TLR3 L and F variants on the viability of human retinal pigment epithelium (RPE) cells in vitro and on RPE cell apoptosis in wildtype and Tlr3−/− mice. RESULTS The F variant (or T allele at single nucleotide polymorphism at rs3775291) was associated with protection against GA (P=0.005); this association was replicated in two independent GA case-control series (P=5.43×10−4 and P=0.002, respectively. We observed no association between TLR3 variants and CNV. The rs377291 variant is probably critical to the function of TLR3, because a prototypic TLR3 ligand induced cell death and apoptosis in human RPE cells with the LL genotype to a greater extent than it did RPE cells with the LF genotype. Moreover, the ligand induced more RPE cell death and apoptosis in wild-type than in Tlr3−/− mice. CONCLUSIONS The TLR3 412F variant confers protection against GA, probably by suppressing RPE cell death. Given that double stranded RNA can activate TLR3-mediated apoptosis, our results suggest a possible role for viral dsRNA transcripts in the development of GA and raise awareness of potential toxicity induced by short interfering RNA (siRNA) therapeutics in the eye. PMID:18753640

The relationship between emotional labor status and workplace violence among toll collectors

OpenAIRE

Joo, Yosub; Rhie, Jeongbae

2017-01-01

Background This study aimed to identify the emotional labor and workplace violence status among toll collectors by assessing and comparing the same with that in workers in other service occupation. It also aimed to analyze the relationship between emotional labor and workplace violence. Methods This study examined emotional labor and workplace violence status in 264 female toll collectors from August 20 to September 4, 2015. The emotional labor was assessed using the Korean Emotional Labor Sc...

DMPD: Signaling to NF-kappaB by Toll-like receptors. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available l Med. 2007 Nov;13(11):460-9. Epub 2007 Oct 29. (.png) (.svg) (.html) (.csml) Show Signaling to NF-kappaB by Toll-like receptors. Pub...medID 18029230 Title Signaling to NF-kappaB by Toll-like receptors. Authors Kawai T

Detector Mount Design for IGRINS

Directory of Open Access Journals (Sweden)

Jae Sok Oh

2014-06-01

Full Text Available The Immersion Grating Infrared Spectrometer (IGRINS is a near-infrared wide-band high-resolution spectrograph jointly developed by the Korea Astronomy and Space Science Institute and the University of Texas at Austin. IGRINS employs three HAWAII-2RG Focal Plane Array (H2RG FPA detectors. We present the design and fabrication of the detector mount for the H2RG detector. The detector mount consists of a detector housing, an ASIC housing, a Field Flattener Lens (FFL mount, and a support base frame. The detector and the ASIC housing should be kept at 65 K and the support base frame at 130 K. Therefore they are thermally isolated by the support made of GFRP material. The detector mount is designed so that it has features of fine adjusting the position of the detector surface in the optical axis and of fine adjusting yaw and pitch angles in order to utilize as an optical system alignment compensator. We optimized the structural stability and thermal characteristics of the mount design using computer-aided 3D modeling and finite element analysis. Based on the structural and thermal analysis, the designed detector mount meets an optical stability tolerance and system thermal requirements. Actual detector mount fabricated based on the design has been installed into the IGRINS cryostat and successfully passed a vacuum test and a cold test.

DMPD: Nuclear factor-kappaB: activation and regulation during toll-like receptorsignaling. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17349209 Nuclear factor-kappaB: activation and regulation during toll-like receptorsignaling. Carmody...uclear factor-kappaB: activation and regulation during toll-like receptorsignaling. Authors Carmody

Mount Athos: Between autonomy and statehood

Directory of Open Access Journals (Sweden)

Avramović Dragutin

2013-01-01

Full Text Available Legal status of the Mount Athos is characterized by many special features that make it internationally unique legal regime. The author analyzes peculiarities of Mount Athos territorial status, legal position of residents and visitors, as well as organization of Mount Athos authorities. The author concludes that the Mount Athos is characterized by a kind of para-sovereignty. Its autonomy involves not only the internal organization, autonomous governance and religious autonomy, but it also includes many elements of secular life of their visitors. Mount Athos has its own, separate legislative, administrative and judicial powers, while the Statute of the Mount Athos has greater legal force than all the other laws of the Greek state, because the state can not unilaterally change its provisions. Having in mind that the wide self-government is vested in church authorities and that the monks have very specific way of living, the author takes a position that the Mount Athos represent 'monastic state', but without statehood. The author also states that the Mount Athos will be faced with many challenges in the context of spreading of an assimilating, universal conception of human rights.

DMPD: Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways inmacrophage activation. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17502339 Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways inmacrophage...May 14. (.png) (.svg) (.html) (.csml) Show Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways inmacrophage...T, Toll-like receptor, and ITAM-dependent pathways inmacrophage activation. Authors Hu X, Chen J, Wang L, Iv

PcToll3 was involved in anti-Vibrio response by regulating the expression of antimicrobial peptides in red swamp crayfish, Procambarus clarkii.

Science.gov (United States)

Lan, Jiang-Feng; Wei, Shun; Wang, Yu-Qing; Dai, Yun-Jia; Tu, Jia-Gang; Zhao, Li-Juan; Li, Xin-Cang; Qin, Qi-Wei; Chen, Nan; Lin, Li

2016-10-01

Tolls and Toll-like receptors (TLRs) play an important role in host immune defenses by regulating the expression of antimicrobial peptides (AMPs) and cytokines, but the functional differences of crustacean Tolls from Drosophila Tolls or Mammal TLRs are largely unknown. A novel Toll receptor, named PcToll3, was identified from red swamp crayfish, Procambarus clarkii. It was widely expressed in all detected tissues, and its transcript in hemocytes was up-regulated at 12 h after Vibrio parahemolyticus (Vibrio) injection or at 24 h post white spot syndrome virus (WSSV) challenge. After knockdown of PcToll3, the activity of bacterial clearance was inhibited, and the expression levels of AMPs including Crustin1 (Cru1), Anti-lippopolysaccharide factor 1 (ALF1), and Lysozymes1 (Lys1), which could be up-regulated by Vibrio, were all affected. Meanwhile, PcToll3 silencing influenced the expression of myeloid differentiation factor 88 (PcMyd88), tumor necrosis factor-associated factor 6 (PcTRAF6), and PcDorsal, which were the counterparts of Drosophila Toll signaling pathway. Interestingly, PcToll3 silencing inhibited translocation of PcDorsal from cytoplasm to nucleus. Furthermore, the knockdown of PcDorsal also impaired the expression of AMPs after Vibrio challenge. Hence, we concluded that, besides participating in antiviral immunity, PcToll3 might also regulate the expression of Cru1 and Lys1 to participate in anti-Vibrio immune responses by promoting PcDorsal translocation into nucleus. Copyright © 2016 Elsevier Ltd. All rights reserved.

Toll-like receptor activation in the pathogenesis of lupus nephritis.

Science.gov (United States)

Lorenz, Georg; Lech, Maciej; Anders, Hans-Joachim

2017-12-01

The pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis is complex but no longer enigmatic. Much progress has been made to on the polygenetic origin of lupus in identifying gene variants that permit the loss of tolerance against nuclear autoantigens. Along the same line in about 50% of lupus patients additional genetic weaknesses promote immune complex glomerulonephritis and filtration barrier dysfunction. Here we briefly summarize the pathogenesis of SLE with a focus on loss of tolerance and the role of toll-like receptors in the "pseudo"-antiviral immunity concept of systemic lupus. In addition, we discuss the local role of Toll-like receptors in intrarenal inflammation and kidney remodeling. Copyright © 2016 Elsevier Inc. All rights reserved.

Ruiz Volcano: Preliminary report

Science.gov (United States)

Ruiz Volcano, Colombia (4.88°N, 75.32°W). All times are local (= GMT -5 hours).An explosive eruption on November 13, 1985, melted ice and snow in the summit area, generating lahars that flowed tens of kilometers down flank river valleys, killing more than 20,000 people. This is history's fourth largest single-eruption death toll, behind only Tambora in 1815 (92,000), Krakatau in 1883 (36,000), and Mount Pelée in May 1902 (28,000). The following briefly summarizes the very preliminary and inevitably conflicting information that had been received by press time.

Can generalized distribution factors lead to ''objective'' transmission toll allocations? Some lessons from the recent Chilean experience

International Nuclear Information System (INIS)

Galetovic, Alexander; Palma-Behnke, Rodrigo

2008-01-01

How to charge for transmission lines in a liberalized electricity market is still a conceptually unresolved issue and the literature offers many methods to determine who ''uses'' a given line and how to allocate tolls among users. But there seems to be some agreement that once a given method is chosen, calculating use and toll allocations is a mere technical matter. We suggest, by contrast that this belief is not warranted. We apply one power flow identification method - generalized load distribution factors - to allocate transmission tolls among the users of the Chilean transmission system and show that almost any allocation of tolls can be achieved by suitably choosing parameter values. Essentially, the method affords many degrees of freedom to the person responsible for setting the parameters needed to apply it. We argue that this suggests that setting parameter values is a central feature of transmission regulation. Moreover, our results suggest that an allocation method cannot answer the key unresolved question in the literature: what is the structure of tolls that gives economically adequate expansion incentives. (author)

Toll-like receptorer, nye behandlingsstrategier?

DEFF Research Database (Denmark)

Pedersen, Claus Vinter Bødker; Østergaard, Lars; Mogensen, Trine

2007-01-01

Toll-like receptors (TLRs) comprise a group of recently discovered receptors which are essential molecular structures in the activation of immunity. The discovery of TLRs has provided a substantial increase in the knowledge of immunologic aspects of disease pathology and is presently giving rise...... to new treatment strategies. This review summarizes the current knowledge on TLRs functioning in infections, their possible roles in inflammatory bowl disease and the pivotal role for TLRs in endotoxic shock, an area which is currently subject to development of a new farmakon. Udgivelsesdato: 2007-Jun-4...

Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent.

Directory of Open Access Journals (Sweden)

Carmen M Dickinson-Copeland

Full Text Available Plasmodium falciparum infection can cause microvascular dysfunction, cerebral encephalopathy and death if untreated. We have previously shown that high concentrations of free heme, and C-X-C motif chemokine 10 (CXCL10 in sera of malaria patients induce apoptosis in microvascular endothelial and neuronal cells contributing to vascular dysfunction, blood-brain barrier (BBB damage and mortality. Endothelial progenitor cells (EPC are microvascular endothelial cell precursors partly responsible for repair and regeneration of damaged BBB endothelium. Studies have shown that EPC's are depleted in severe malaria patients, but the mechanisms mediating this phenomenon are unknown. Toll-like receptors recognize a wide variety of pathogen-associated molecular patterns generated by pathogens such as bacteria and parasites. We tested the hypothesis that EPC depletion during malaria pathogenesis is a function of heme-induced apoptosis mediated by CXCL10 induction and toll-like receptor (TLR activation. Heme and CXCL10 concentrations in plasma obtained from malaria patients were elevated compared with non-malaria subjects. EPC numbers were significantly decreased in malaria patients (P < 0.02 and TLR4 expression was significantly elevated in vivo. These findings were confirmed in EPC precursors in vitro; where it was determined that heme-induced apoptosis and CXCL10 expression was TLR4-mediated. We conclude that increased serum heme mediates depletion of EPC during malaria pathogenesis.

DMPD: Interferon gene regulation: not all roads lead to Tolls. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 16095970 Interferon gene regulation: not all roads lead to Tolls. Jefferies CA, Fit...zgerald KA. Trends Mol Med. 2005 Sep;11(9):403-11. (.png) (.svg) (.html) (.csml) Show Interferon gene regulation: not all roads... lead to Tolls. PubmedID 16095970 Title Interferon gene regulation: not all roads lead to

Minnesota urban partnership agreement national evaluation : tolling test plan.

Science.gov (United States)

2009-11-17

This report presents the test plan for collecting and analyzing toll data for the Minnesota Urban Partnership : Agreement (UPA) under the United States Department of Transportation (U.S. DOT) UPA Program. The : Minnesota UPA projects focus on reducin...

Flush Mounting Of Thin-Film Sensors

Science.gov (United States)

Moore, Thomas C., Sr.

1992-01-01

Technique developed for mounting thin-film sensors flush with surfaces like aerodynamic surfaces of aircraft, which often have compound curvatures. Sensor mounted in recess by use of vacuum pad and materials selected for specific application. Technique involves use of materials tailored to thermal properties of substrate in which sensor mounted. Together with customized materials, enables flush mounting of thin-film sensors in most situations in which recesses for sensors provided. Useful in both aircraft and automotive industries.

Electronic Toll Collection Systems and their Interoperability: The State of Art

Energy Technology Data Exchange (ETDEWEB)

Heras Molina, J. de la; Gomez Sanchez, J.; Vassallo Magro, J.M.

2016-07-01

The European Electronic Toll Service (EETS) was created in 2004 with the aim of ensuring interoperability among the existing electronic toll collection (ETC) systems in Europe. However, the lack of cooperation between groups of stakeholders has not made possible to achieve this goal ten years later. The purpose of this research is to determine the better way to achieve interoperability among the different ETC systems in Europe. Our study develops a review of the six main ETC systems available worldwide: Automatic Number Plate Recognition (ANPR), Dedicated Short-Range Communications (DSRC), Radio Frequency Identification (RFID), Satellite systems (GNSS), Tachograph, and Mobile communications tolling systems. The research also provides some insight on different emerging technologies. By focusing on different operational and strategic aspects offered by each technology, we identify their main strengths, weaknesses, opportunities and threats and makes different recommendations to improve the current framework. The research concludes that given the diversity of advantages and inconveniences offered by each system, the selection of a certain ETC technology should also take into account its potential to overcome the weaknesses in the current ETC framework. In this line, different policy recommendations are proposed to improve the present ETC strategy at the EU. (Author)

Measuring the Capacity and Transaction Time of Cash and Electronic Toll Collection Systems

Directory of Open Access Journals (Sweden)

Rudy Hermawan Karsaman

2014-07-01

Full Text Available A long queue can occur at tollgates due to the amount of transaction time required to perform ticket payment and toll fee collection. This problem can be addressed by the use of an electronic toll collection (ETC system. A case study conducted on the Jakarta Intra Urban, Cikupa-Merak, and Cawang Pluit Toll Roads suggests that the queueing at the tollgates when modelled followed a Poisson distribution. The average cash transaction time was approximately 5 to 6 seconds, while the ETC transaction time was only 4 seconds. Furthermore, the capacity of the cash system gate was 550 to 620 vehicles/hour (which is above the minimum service standard of 450 vehicles/hour,whereas the electronic gate capacity was 770 to 870 vehicles/hour. This study demonstrates that the ETC system is more effective than the cash system in terms of reducing the number of queueing vehicles.

Characterization of Engine Mount Elastomers

National Research Council Canada - National Science Library

Szabo, Jeffrey P

2005-01-01

As part of a project to develop methods for modelling the performance of engine mounts, several oil resistant alternative materials were prepared, and compared to conventional materials from mounts...

Toll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium.

Directory of Open Access Journals (Sweden)

Idir Akhouayri

2011-10-01

Full Text Available Barrier epithelia that are persistently exposed to microbes have evolved potent immune tools to eliminate such pathogens. If mechanisms that control Drosophila systemic responses are well-characterized, the epithelial immune responses remain poorly understood. Here, we performed a genetic dissection of the cascades activated during the immune response of the Drosophila airway epithelium i.e. trachea. We present evidence that bacteria induced-antimicrobial peptide (AMP production in the trachea is controlled by two signalling cascades. AMP gene transcription is activated by the inducible IMD pathway that acts non-cell autonomously in trachea. This IMD-dependent AMP activation is antagonized by a constitutively active signalling module involving the receptor Toll-8/Tollo, the ligand Spätzle2/DNT1 and Ect-4, the Drosophila ortholog of the human Sterile alpha and HEAT/ARMadillo motif (SARM. Our data show that, in addition to Toll-1 whose function is essential during the systemic immune response, Drosophila relies on another Toll family member to control the immune response in the respiratory epithelium.

Analysis of potential diverted of passenger car to the new toll road (case study: Cileunyi - Sumedang, West Java)

Science.gov (United States)

Prahara, Eduardi; Suangga, Made; Lutfi Ansori, Ahmad

2017-12-01

This study aims to determine of potential of passenger car divert from national road to on-construction Cisumdawu Toll Road. The study was conducted by traffic count survey and followed by a roadside interview survey. Stated Preference method was used in order to analyse trip forecasting value. Mode choice model of new trip mode plans (Cisumdawu Toll Road) and current intercity road for Cileunyi - Sumedang is (UJT -UJR ) = 0.1079-0.507726x 1-0.8953764x 2, while Sumedang - Cileunyi is (UJT -UJR ) = 0.0790-0.301341x 1-0.548446x 2. Multiple linear regression analysis was used to obtain the forecasting of private vehicle that diverts to the new toll road (Cisumdawu Toll Road). Trip characteristics such as trip origin and destination, types of trips, occupations, salary, and others become a motive for respondents to choose a new trip mode. Results of the new trip mode forecasting that prefer to divert to the toll road in terms of the value of cost and time for Cileunyi - Sumedang are 74.11% and 86.62% respectively, while for Sumedang - Cileunyi are 69.60% and 76.48% respectively. These results are relatively high compare to toll planning document. The impact of this results can be determined such as lower overall fuel consumption, lower pollution and more important is the maintenance cost of national road will be decrease.

Solar panel parallel mounting configuration

Science.gov (United States)

Mutschler, Jr., Edward Charles (Inventor)

1998-01-01

A spacecraft includes a plurality of solar panels interconnected with a power coupler and an electrically operated device to provide power to the device when the solar cells are insolated. The solar panels are subject to bending distortion when entering or leaving eclipse. Spacecraft attitude disturbances are reduced by mounting each of the solar panels to an elongated boom made from a material with a low coefficient of thermal expansion, so that the bending of one panel is not communicated to the next. The boom may be insulated to reduce its bending during changes in insolation. A particularly advantageous embodiment mounts each panel to the boom with a single mounting, which may be a hinge. The single mounting prevents transfer of bending moments from the panel to the boom.

DMPD: Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation inrespiratory disease. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 18031251 Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation inrespiratory...l) (.csml) Show Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation inrespiratory dis...utrophilic inflammation inrespiratory disease. Authors Sabroe I, Whyte MK. Publication Biochem Soc Trans. 20

76 FR 46897 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

Science.gov (United States)

2011-08-03

... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Panel Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted....C. App. (1988) that an open meeting of the Taxpayer Advocacy Panel Small Business/Self Employed...

76 FR 6190 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

Science.gov (United States)

2011-02-03

... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Panel Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted....C. App. (1988) that an open meeting of the Taxpayer Advocacy Panel Small Business/Self Employed...

76 FR 37893 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

Science.gov (United States)

2011-06-28

... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Panel Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted....C. App. (1988) that an open meeting of the Taxpayer Advocacy Panel Small Business/Self Employed...

76 FR 10942 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

Science.gov (United States)

2011-02-28

... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Panel Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted....C. App. (1988) that an open meeting of the Taxpayer Advocacy Panel Small Business/Self Employed...

DMPD: Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs andCTRPs. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17681884 Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs an...ng) (.svg) (.html) (.csml) Show Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs andC...TRPs. PubmedID 17681884 Title Adipose tissue as an immunological organ: Toll-like

Low-dose radiation induces drosophila innate immunity through toll pathway activation

International Nuclear Information System (INIS)

Seong, Ki Moon; Kim, Cha Soon; Lee, Byung-Sub; Nam, Seon Young; Yang, Kwang Hee; Kim, Ji-Young; Jin, Young-Woo; Park, Joong-Jean; Min, Kyung-Jin

2012-01-01

Numerous studies report that exposing certain organisms to low-dose radiation induces beneficial effects on lifespan, tumorigenesis, and immunity. By analyzing survival after bacterial infection and antimicrobial peptide gene expression in irradiated flies, we demonstrate that low-dose irradiation of Drosophila enhances innate immunity. Low-dose irradiation of flies significantly increased resistance against gram-positive and gram-negative bacterial infections, as well as expression of several antimicrobial peptide genes. Additionally, low-dose irradiation also resulted in a specific increase in expression of key proteins of the Toll signaling pathway and phosphorylated forms of p38 and N-terminal kinase (JNK). These results indicate that innate immunity is activated after low-dose irradiation through Toll signaling pathway in Drosophila. (author)

Mounting Thin Samples For Electrical Measurements

Science.gov (United States)

Matus, L. G.; Summers, R. L.

1988-01-01

New method for mounting thin sample for electrical measurements involves use of vacuum chuck to hold a ceramic mounting plate, which holds sample. Contacts on mounting plate establish electrical connection to sample. Used to make electrical measurements over temperature range from 77 to 1,000 K and does not introduce distortions into magnetic field during Hall measurements.

Resilient mounting systems in buildings

NARCIS (Netherlands)

Breeuwer, R.; Tukker, J.C.

1976-01-01

The basic elements of resilient mounting systems are described and various measures for quantifying the effect of such systems defined. Using electrical analogue circuits, the calculation of these measures is illustrated. With special reference to resilient mounting systems in buildings, under

76 FR 17996 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

Science.gov (United States)

2011-03-31

... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted. The... Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer Advocacy Panel Small Business/Self...

76 FR 22170 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

Science.gov (United States)

2011-04-20

... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted. The... hereby given pursuant to Section 10(a)(2) of the Federal Advisory Committee Act, 5 U.S.C. App. (1988...

The politics of death in Mexico: dislocating human rights and asylum law through hybrid agents.

Directory of Open Access Journals (Sweden)

Ariadna Estévez

2013-12-01

Full Text Available In 2006 Mexico’s then-president Felipe Calderón declared war on drug trafficking. The human toll was devastating with the loss of over 95,000 lives and the forced disappearance of more than 27,000 people. In addition, two percent of the Mexican population was displaced with families forced to flee their homes in the face of criminal violence. This article offers an explanation of how death, forced disappearances, persecution and exile are in essence the specific effects of governmentalization of the Mexican state. This govern­mentalization includes the shared use, by criminals and authorities, of techniques for dominating the population and controlling the conduct of citizens through the practices of death, that is, by employing the politics of death (necropolitics. The article goes on to discuss how the objectives, rationality and governmentalization of the State serve to dislocate human rights discourse in such a way that its truth politics excludes people suffering serious human rights violations, such as Mexican asylum seekers. This is accompanied by a new mode of subjectivity produced by Mexico's politics of death – the Endriago subject – which operates as a hybrid perpetrator of human rights violations.

Low-Thermal-Resistance Baseplate Mounting

Science.gov (United States)

Perreault, W. T.

1984-01-01

Low-thermal-resistance mounting achieved by preloading baseplate to slight convexity with screws threaded through beam. As mounting bolts around edge of base-place tightened, baseplate and cold plate contact first in center, with region of intimate contact spreading outward as bolts tightened.

An improved loopless mounting method for cryocrystallography

International Nuclear Information System (INIS)

Jian-Xun, Qi; Fan, Jiang

2010-01-01

Based on a recent loopless mounting method, a simplified loopless and bufferless crystal mounting method is developed for macromolecular crystallography. This simplified crystal mounting system is composed of the following components: a home-made glass capillary, a brass seat for holding the glass capillary, a flow regulator, and a vacuum pump for evacuation. Compared with the currently prevalent loop mounting method, this simplified method has almost the same mounting procedure and thus is compatible with the current automated crystal mounting system. The advantages of this method include higher signal-to-noise ratio, more accurate measurement, more rapid flash cooling, less x-ray absorption and thus less radiation damage to the crystal. This method can be extended to the flash-freeing of a crystal without or with soaking it in a lower concentration of cryoprotectant, thus it may be the best option for data collection in the absence of suitable cryoprotectant. Therefore, it is suggested that this mounting method should be further improved and extensively applied to cryocrystallographic experiments. (general)

An improved loopless mounting method for cryocrystallography

Science.gov (United States)

Qi, Jian-Xun; Jiang, Fan

2010-01-01

Based on a recent loopless mounting method, a simplified loopless and bufferless crystal mounting method is developed for macromolecular crystallography. This simplified crystal mounting system is composed of the following components: a home-made glass capillary, a brass seat for holding the glass capillary, a flow regulator, and a vacuum pump for evacuation. Compared with the currently prevalent loop mounting method, this simplified method has almost the same mounting procedure and thus is compatible with the current automated crystal mounting system. The advantages of this method include higher signal-to-noise ratio, more accurate measurement, more rapid flash cooling, less x-ray absorption and thus less radiation damage to the crystal. This method can be extended to the flash-freeing of a crystal without or with soaking it in a lower concentration of cryoprotectant, thus it may be the best option for data collection in the absence of suitable cryoprotectant. Therefore, it is suggested that this mounting method should be further improved and extensively applied to cryocrystallographic experiments.

For Whom the Bell Tolls (and Nods): Spit-acular Saliva

Czech Academy of Sciences Publication Activity Database

Shaw, D.K.; Kotsyfakis, Michalis; Pedra, J. H. F.

2016-01-01

Roč. 3, č. 2 (2016), s. 40-50 E-ISSN 2196-3045 Institutional support: RVO:60077344 Keywords : tick-borne diseases * tick saliva * innate immune signaling * toll-like receptor (TLR) * nod-like receptor (NLR) Subject RIV: EC - Immunology

76 FR 56880 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

Science.gov (United States)

2011-09-14

... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted. The...: Notice is hereby given pursuant to Section 10(a)(2) of the Federal Advisory Committee Act, 5 U.S.C. App...

76 FR 63716 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

Science.gov (United States)

2011-10-13

... Small Business/Self Employed Correspondence Exam Toll Free Project Committee AGENCY: Internal Revenue... Small Business/ Self Employed Correspondence Exam Toll Free Project Committee will be conducted. The...: Notice is hereby given pursuant to Section 10(a)(2) of the Federal Advisory Committee Act, 5 U.S.C. App...

76 FR 2196 - Open Meeting of the Taxpayer Advocacy Panel Small Business/Self Employed Correspondence Exam Toll...

Science.gov (United States)

2011-01-12

... Small Business/Self Employed Correspondence Exam Toll Free AGENCY: Internal Revenue Service (IRS.../ Self Employed Correspondence Exam Toll Free will be conducted. The Taxpayer Advocacy Panel is... pursuant to Section 10(a)(2) of the Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open...

Evaluation of implementation viability gap funding (VGF) policy on toll road investment in Indonesia

Science.gov (United States)

Mahani, Iris; Tamin, Rizal Z.; Pribadi, Krishna S.; Wibowo, Andreas

2017-11-01

VGF policy for toll road investment in Indonesia must be reviewed. Since 2012 the Government of Indonesia (GOI) has issued viability gap funding (VGF) policy for PPP infrastructure project through ministry of finance decision (PMK) No.223/2012. One of VGF purpose is to improve the financial feasibility. In the toll road investment in Indonesia, the implementation of this policy has some problems. This study aimed to evaluate the policy by seeking implementation constraints so can be given an alternative. This research was conducted qualitatively, included aspects of implementation process VGF policy. The analysis process is based on literature study and in-depth interviews to related parties include business entity, ministry of finance, and the ministry of public works, Indonesia Toll Road Authority (BPJT) and professional societies. The literature review conducted by reviewing existing policies and best practices in countries that already practice VGF. The conclusion of this study are 1) There is a conflict of regulation in viability gap funding (VGF) for toll road investment in Indonesia; 2) If Government of Indonesia (GOI) want implement construction grant as VGF, so the regulation must improve in time limited for submission and clearly define limited given in regulation; 3) If GOI want implement partial construction as VGF, so the regulation must be improve in guideline for submission and given.

Logit and probit model in toll sensitivity analysis of Solo-Ngawi, Kartasura-Palang Joglo segment based on Willingness to Pay (WTP)

Science.gov (United States)

Handayani, Dewi; Cahyaning Putri, Hera; Mahmudah, AMH

2017-12-01

Solo-Ngawi toll road project is part of the mega project of the Trans Java toll road development initiated by the government and is still under construction until now. PT Solo Ngawi Jaya (SNJ) as the Solo-Ngawi toll management company needs to determine the toll fare that is in accordance with the business plan. The determination of appropriate toll rates will affect progress in regional economic sustainability and decrease the traffic congestion. These policy instruments is crucial for achieving environmentally sustainable transport. Therefore, the objective of this research is to find out how the toll fare sensitivity of Solo-Ngawi toll road based on Willingness To Pay (WTP). Primary data was obtained by distributing stated preference questionnaires to four wheeled vehicle users in Kartasura-Palang Joglo artery road segment. Further data obtained will be analysed with logit and probit model. Based on the analysis, it is found that the effect of fare change on the amount of WTP on the binomial logit model is more sensitive than the probit model on the same travel conditions. The range of tariff change against values of WTP on the binomial logit model is 20% greater than the range of values in the probit model . On the other hand, the probability results of the binomial logit model and the binary probit have no significant difference (less than 1%).

Multi-Mounted X-Ray Computed Tomography.

Science.gov (United States)

Fu, Jian; Liu, Zhenzhong; Wang, Jingzheng

2016-01-01

Most existing X-ray computed tomography (CT) techniques work in single-mounted mode and need to scan the inspected objects one by one. It is time-consuming and not acceptable for the inspection in a large scale. In this paper, we report a multi-mounted CT method and its first engineering implementation. It consists of a multi-mounted scanning geometry and the corresponding algebraic iterative reconstruction algorithm. This approach permits the CT rotation scanning of multiple objects simultaneously without the increase of penetration thickness and the signal crosstalk. Compared with the conventional single-mounted methods, it has the potential to improve the imaging efficiency and suppress the artifacts from the beam hardening and the scatter. This work comprises a numerical study of the method and its experimental verification using a dataset measured with a developed multi-mounted X-ray CT prototype system. We believe that this technique is of particular interest for pushing the engineering applications of X-ray CT.

DMPD: Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 15051069 Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Miy...ake K. Trends Microbiol. 2004 Apr;12(4):186-92. (.png) (.svg) (.html) (.csml) Show Innate recognition of lip...opolysaccharide by Toll-like receptor 4-MD-2. PubmedID 15051069 Title Innate recognition of lipopolysacchari

Housing And Mounting Structure

Science.gov (United States)

Anderson, Gene R.; Armendariz, Marcelino G.; Baca, Johnny R.F.; Bryan, Robert P.; Carson, Richard F.; Duckett, III, Edwin B.; McCormick, Frederick B.; Miller, Gregory V.; Peterson, David W.; Smith, Terrance T.

2005-03-08

This invention relates to an optical transmitter, receiver or transceiver module, and more particularly, to an apparatus for connecting a first optical connector to a second optical connector. The apparatus comprises: (1) a housing having at least a first end and at least a second end, the first end of the housing capable of receiving the first optical connector, and the second end of the housing capable of receiving the second optical connector; (2) a longitudinal cavity extending from the first end of the housing to the second end of the housing; and (3) an electromagnetic shield comprising at least a portion of the housing. This invention also relates to an apparatus for housing a flexible printed circuit board, and this apparatus comprises: (1) a mounting structure having at least a first surface and a second surface; (2) alignment ridges along the first and second surfaces of the mounting structure, the alignment ridges functioning to align and secure a flexible printed circuit board that is wrapped around and attached to the first and second surfaces of the mounting structure; and (3) a series of heat sink ridges adapted to the mounting structure, the heat sink ridges functioning to dissipate heat that is generated from the flexible printed circuit board.

Toll-like receptor-4 (TLR-4) expression on polymorphonuclear ...

African Journals Online (AJOL)

To establish a foundation for further researches on the improvement of polymorphonuclear neutrophil leukocytes (PMN) functions in dairy cow during perinatal period, the counting of PMN, as well as the mRNA and protein expression of toll-like receptor-4 (TLR-4) on PMN was studied during this critical period.

23 CFR 661.49 - Can IRRBP funds be spent on Interstate, State Highway, and Toll Road IRR bridges?

Science.gov (United States)

2010-04-01

..., and Toll Road IRR bridges? 661.49 Section 661.49 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.49 Can IRRBP funds be spent on Interstate, State Highway, and Toll Road IRR bridges? Yes. Interstate...

PECULIARITIES OF ASSIGNMENT OF ROLLING BEARING MOUNTING AND PARAMETERS OF GEOMETRIC ACCURACY OF MOUNTING SURFACES OF SHAFTS AND FRAMES

Directory of Open Access Journals (Sweden)

Adamenko Yu. І.

2017-04-01

Full Text Available The standards and methods concerning assignment of rolling bearing fit with shafts and frames via example of bearing 6-208 are analyzed. We set certain differences of recommendations according to GOST 3325-85, "Rolling bearings. Tolerance zones and technical requirements to mounting surfaces of shafts and frames. Attachment" and by reference of rolling bearing manufacturers. The following factors should be taken into consideration when assigning the mounting with the tension the internal ring of the bearing with shaft and mounting with a gap in the outer ring with a housing bore. The methods of achieving accuracy of mounting surfaces of shafts and frames via form tolerance assignment: roundness tolerance, profile of longitudinal cut, cross section, cylindricity and others. It is possible to limit the bearing rings in different ways, for example appointing the cylindrical mounting surfaces and bead end surfaces the appropriate tolerances, namely: coaxiality tolerance or full radial beat of mounting surfaces, and also perpendicularity tolerance, butt beats and full butt beats of mounting end surfaces. We suggest to expand methods of achieving the accuracy of shafts and frames depending on seriation of production and production operations metrology support.

Effectiveness of the toll-free line for public insurance programs.

Science.gov (United States)

Saunders, Cynthia M

2005-03-01

Toll-free lines for public insurance programs are a major point of entry to inquire about information. More than 1 million Californians are eligible for public insurance programs based on income but not yet enrolled. In 2000 and 2002, a "mystery-shopper" survey was conducted to ascertain overall effectiveness and interlanguage variation for information provided in Armenian, Cantonese, English, Farsi, Hmong, Khmer, Korean, Russian, Spanish, and Vietnamese. Although the 2002 study showed statistically significant improvements from 2000, many constructs remained problematic. In 2002, for example, statistically significant interlanguage variation was identified in discussing and checking eligibility for the program. Specifically, Spanish and Armenian callers were less likely than other language callers to have eligibility checked or deemed eligible. Removing barriers to enrollment in public insurance programs often requires political solutions, but improving customer service for the toll-free line necessitates efficiency and a focus on continuous quality improvement.

DMPD: Toll-like receptors and the host defense against microbial pathogens: bringingspecificity to the innate-immune system. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 15075354 Toll-like receptors and the host defense against microbial pathogens: brin...oc Biol. 2004 May;75(5):749-55. Epub 2004 Jan 14. (.png) (.svg) (.html) (.csml) Show Toll-like receptors and the host defense again...immune system. PubmedID 15075354 Title Toll-like receptors and the host defense against microbial pathogens:

The TIR domain of TIR-NB-LRR resistance proteins is a signaling domain involved in cell death induction.

Science.gov (United States)

Swiderski, Michal R; Birker, Doris; Jones, Jonathan D G

2009-02-01

In plants, the TIR (toll interleukin 1 receptor) domain is found almost exclusively in nucleotide-binding (NB) leucine-rich repeat resistance proteins and their truncated homologs, and has been proposed to play a signaling role during resistance responses mediated by TIR containing R proteins. Transient expression in Nicotiana benthamiana leaves of "TIR + 80", the RPS4 truncation without the NB-ARC domain, leads to EDS1-, SGT1-, and HSP90-dependent cell death. Transgenic Arabidopsis plants expressing the RPS4 TIR+80 from either dexamethasone or estradiol-inducible promoters display inducer-dependent cell death. Cell death is also elicited by transient expression of similarly truncated constructs from two other R proteins, RPP1A and At4g19530, but is not elicited by similar constructs representing RPP2A and RPP2B proteins. Site-directed mutagenesis of the RPS4 TIR domain identified many loss-of-function mutations but also revealed several gain-of function substitutions. Lack of cell death induction by the E160A substitution suggests that amino acids outside of the TIR domain contribute to cell death signaling in addition to the TIR domain itself. This is consistent with previous observations that the TIR domain itself is insufficient to induce cell death upon transient expression.

Mounting support for a photovoltaic module

Science.gov (United States)

Brandt, Gregory Michael; Barsun, Stephan K.; Coleman, Nathaniel T.; Zhou, Yin

2013-03-26

A mounting support for a photovoltaic module is described. The mounting support includes a foundation having an integrated wire-way ledge portion. A photovoltaic module support mechanism is coupled with the foundation.

Structure-based drug design approach to target toll-like receptor ...

African Journals Online (AJOL)

Toll-like receptor (TLR) signaling pathways are the first line of defence against many microbial organisms. The question of how TLRs recognize endogenous ligands remains controversial. Several studies have shown that TLRs are implicated in the pathogenesis of autoimmune diseases such as systemic lupus ...

DMPD: MyDths and un-TOLLed truths: sensor, instructive and effector immunity totuberculosis. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 18191460 MyDths and un-TOLLed truths: sensor, instructive and effector immunity totuberculosis...g) (.svg) (.html) (.csml) Show MyDths and un-TOLLed truths: sensor, instructive and effector immunity totuberculosis...e and effector immunity totuberculosis. Authors Reiling N, Ehlers S, Holscher C. Publication Immunol Lett. 2

DMPD: The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17449723 The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. Sh...Show The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. PubmedID 17449723 Title The Tro...ll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. Authors Sheedy F

Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells

DEFF Research Database (Denmark)

Chen, R; Alvero, A B; Silasi, D-A

2008-01-01

proliferation, would also be key factors in regulating and enhancing cancer progression. The TLR pathways, which play a critical role in tissue repair, are also key regulators in cancer progression as well as chemoresistance. TLRs serve as cell surface sensors that can initiate pathways leading to proliferation......Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore, it would not be surprising that factors that function in the tissue repair process, such as cytokines, chemokines, growth factors and Toll-like receptor (TLR) ligands, as well as growth signals for compensatory...... and chemoresistance; as well as mediators that are able to regulate the infiltrating immune cells to provide further support for cancer progression....

DMPD: Toll-like receptors: from the discovery of NFkappaB to new insights intotranscriptional regulations in innate immunity. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 16930560 Toll-like receptors: from the discovery of NFkappaB to new insights intotr...2-13. Epub 2006 Aug 22. (.png) (.svg) (.html) (.csml) Show Toll-like receptors: from the discovery of NFkapp...6930560 Title Toll-like receptors: from the discovery of NFkappaB to new insights intotranscriptional regula

Design and operation of a high-heat flux, flush-mounted ‘rail’ Langmuir probe array on Alcator C-Mod

Directory of Open Access Journals (Sweden)

A.Q. Kuang

2017-08-01

Full Text Available A poloidal array of toroidally-extended, flush-mounted ‘rail’ Langmuir probes was recently installed on Alcator C-Mod's vertical target plate divertor. The aim was to investigate if a Langmuir probe array could be designed to survive reactor-level heat fluxes and have the ability to make measurements that could be reliably interpreted under reactor-level plasma densities, neutral densities and magnetic fields. Langmuir probes are typically built to have incident field-line angles >10° to avoid interpretation issues associated with sheath expansion. However, at the high parallel heat fluxes experienced in reactor-relevant conditions such a probe would quickly overheat and melt. To mitigate both the issues of extreme heat flux and sheath expansion, each probe was designed to be flush with the divertor surface, toroidally-extended and field-aligned, giving it a ‘rail’ geometry. The flush mounted probes have proven to be exceptionally robust surviving the 2015–2016 campaign – a first for a C-Mod probe system. Examination of the probe current-voltage (I-V characteristics reveals that they are immune to sheath expansion at incident field angles down to ∼0.5°. Comparison of the flush probes to traditional proud probes shows that both measure the same electron pressure across the divertor plate. However, there are significant and systematic differences in the density, temperature and floating potential. This suggests that there is important physics, perhaps unique to conditions in a vertical-target plate divertor with small field-line attack angles, that affects the I-V characteristics and is not currently included in probe data analyses. Finally, the probe response is examined in the ‘death-ray’ regime, just near detachment. Previous work using proud probes has suggested that the ‘death-ray’ is an artefact of the probe bias. However, on flush mounted probes the ‘death-ray’ manifests itself under different conditions, which

Systems and methods for mirror mounting with minimized distortion

Science.gov (United States)

Antonille, Scott R. (Inventor); Wallace, Thomas E. (Inventor); Content, David A. (Inventor); Wake, Shane W. (Inventor)

2012-01-01

A method for mounting a mirror for use in a telescope includes attaching the mirror to a plurality of adjustable mounts; determining a distortion in the mirror caused by the plurality adjustable mounts, and, if the distortion is determined to be above a predetermined level: adjusting one or more of the adjustable mounts; and determining the distortion in the mirror caused by the adjustable mounts; and in the event the determined distortion is determined to be at or below the predetermined level, rigidizing the adjustable mounts.

Toll-like receptor and associated regulators in pneumonia and sepsis

NARCIS (Netherlands)

Blok, D.C.

2015-01-01

Humanity struggles against micro-organism invasion on a daily basis. Innate immunity is part of the first line of defense when it comes to preventing infection, signaling a perceived health threat and eliminating microbes before they can cause harm. Toll-like receptors (TLRs) and other pattern

Technical preparation of the Yuzhteploehnergomontazh trust for technological equipment mounting

International Nuclear Information System (INIS)

Zayats, A.I.

1982-01-01

Measures of technical preparation for equipment mounting at the Zaporozhe NPP developed with the Yuzhteploehnergomontazh trust experts are considered. These measures envisage the construction of mounting base of heat facilities, calculation of labour contents and determination of necessary quantity of mounters, development of optimal flowsheet of mounting control, improvement of mounting qualification and creation of stable collective body, improvement of technical level of mounting and welding works, organizational-technical measures on mounting logistics. Factors affecting negatively technical preparation quality of equipment mounting at the Zaporozhe NPP are discussed. The flowsheet of mounting control is presented

Combat vehicle crew helmet-mounted display: next generation high-resolution head-mounted display

Science.gov (United States)

Nelson, Scott A.

1994-06-01

The Combat Vehicle Crew Head-Mounted Display (CVC HMD) program is an ARPA-funded, US Army Natick Research, Development, and Engineering Center monitored effort to develop a high resolution, flat panel HMD for the M1 A2 Abrams main battle tank. CVC HMD is part of the ARPA High Definition Systems (HDS) thrust to develop and integrate small (24 micrometers square pels), high resolution (1280 X 1024 X 6-bit grey scale at 60 frame/sec) active matrix electroluminescent (AMEL) and active matrix liquid crystal displays (AMLCD) for head mounted and projection applications. The Honeywell designed CVC HMD is a next generation head-mounted display system that includes advanced flat panel image sources, advanced digital display driver electronics, high speed (> 1 Gbps) digital interconnect electronics, and light weight, high performance optical and mechanical designs. The resulting dramatic improvements in size, weight, power, and cost have already led to program spin offs for both military and commercial applications.

Toll-like receptor 3 blockade in rhinovirus-induced experimental asthma exacerbations

DEFF Research Database (Denmark)

Silkoff, Philip E; Flavin, Susan; Gordon, Robert

2017-01-01

BACKGROUND: Human rhinoviruses (HRVs) commonly precipitate asthma exacerbations. Toll-like receptor 3, an innate pattern recognition receptor, is triggered by HRV, driving inflammation that can worsen asthma. OBJECTIVE: We sought to evaluate an inhibitory mAb to Toll-like receptor 3, CNTO3157......, respectively, and were then inoculated with HRV-16 within 72 hours. All subjects were monitored for respiratory symptoms, lung function, and nasal viral load. The primary end point was maximal decrease in FEV1 during 10 days after inoculation. RESULTS: In asthmatic patients (n = 63) CNTO3157 provided......: In summary, CNTO3157 was ineffective in attenuating the effect of HRV-16 challenge on lung function, asthma control, and symptoms in asthmatic patients but suppressed cold symptoms in healthy subjects. Other approaches, including blockade of multiple pathways or antiviral agents, need to be sought...

Modeling Single Occupant Vehicle Behavior in High-Occupancy Toll (HOT) Facilities

Science.gov (United States)

2009-12-14

High-occupancy toll (HOT) lanes are in operation, under construction, and planned for in several major metropolitan areas. The premise behind HOT lanes is to allow single occupant vehicles (SOVs) to access high occupancy vehicle (HOV) lanes (and theo...

Defining Toll Fee of Wheeling Renewable with Reference to a Gas Pipeline in Indonesia

Science.gov (United States)

Hakim, Amrullah

2017-07-01

Indonesia has a huge number of renewable energy sources (RE) however; the utilization of these is currently very low. The main challenge of power production is its alignment with consumption levels; supply should equal demand at all times. There is a strong initiative from corporations with high energy demand, compared to other sectors, to apply a renewable portfolio standard for their energy input, e.g. 15% of their energy consumption requirement must come from a renewable energy source. To support this initiative, the utilization of power wheeling will help large factories on industrial estates to source firm and steady renewables from remote sites. The wheeling renewable via PLN’s transmission line has been regulated under the Ministry Decree in 2015 however; the tariff or toll fee has not yet been defined. The potential project to apply wheeling renewable will obtain power supply from a geothermal power plant, with power demand from the scattered factories under one company. This is the concept driving the application of power wheeling in the effort to push the growth of renewable energy in Indonesia. Given that the capacity of PLN’s transmission line are normally large and less congested compared to distribution line, the wheeling renewable can accommodate the scattered factories locations which then results in the cheaper toll fee of the wheeling renewable. Defining the best toll fee is the main topic of this paper with comparison of the toll fee of the gas pipeline infrastructure in Indonesia, so that it can be applied massively to achieve COP21’s commitment.

DMPD: Innate immune sensing of pathogens and danger signals by cell surface Toll-likereceptors. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17275324 Innate immune sensing of pathogens and danger signals by cell surface Toll... Show Innate immune sensing of pathogens and danger signals by cell surface Toll-likereceptors. PubmedID 172...75324 Title Innate immune sensing of pathogens and danger signals by cell surface

Mounting and Alignment of IXO Mirror Segments

Science.gov (United States)

Chan, Kai-Wing; Zhang, William; Evans, Tyler; McClelland, Ryan; Hong, Melinda; Mazzarella, James; Saha, Timo; Jalota, Lalit; Olsen, Lawrence; Byron, Glenn

2010-01-01

A suspension-mounting scheme is developed for the IXO (International X-ray Observatory) mirror segments in which the figure of the mirror segment is preserved in each stage of mounting. The mirror, first fixed on a thermally compatible strongback, is subsequently transported, aligned and transferred onto its mirror housing. In this paper, we shall outline the requirement, approaches, and recent progress of the suspension mount processes.

14 CFR 33.23 - Engine mounting attachments and structure.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Engine mounting attachments and structure... mounting attachments and structure. (a) The maximum allowable limit and ultimate loads for engine mounting attachments and related engine structure must be specified. (b) The engine mounting attachments and related...

The TRIPS (Toll-like receptors in immuno-inflammatory pathogenesis) Hypothesis: a novel postulate to understand schizophrenia.

Science.gov (United States)

Venkatasubramanian, Ganesan; Debnath, Monojit

2013-07-01

Mounting evidence indicates that immune activation and/or immuno-inflammatory reactions during neurodevelopment apparently contribute to the pathogenesis and progression of schizophrenia. One of the important environmental factors that is known to trigger immune activation/inflammatory responses during early pregnancy is prenatal infection. Recent understanding from animal studies suggests that prenatal infection induced maternal immune activation (MIA)/inflammation in congruence with oxidative/nitrosative stress can lead to neurodevelopmental damage and behavioral abnormalities in the offspring. Although the underlying precise mechanistic processes of MIA/inflammation are yet to be completely elucidated, it is being increasingly recognized that Toll-like receptors (TLRs) that form the first line of defense against invading microorganisms could participate in the prenatal infection induced immune insults. Interestingly, some of the TLRs, especially TLR3 and TLR4 that modulate neurodevelopment, neuronal survival and neuronal plasticity by regulating the neuro-immune cross-talk in the developing and adult brain could also be affected by prenatal infection. Importantly, sustained activation of TLR3/TLR4 due to environmental factors including infection and stress has been found to generate excessive reactive oxygen species (ROS)/reactive nitrogen species (RNS) as well as pro-inflammatory mediators during embryogenesis, which result into neuronal damage by necrosis/apoptosis. In recent times, ROS/RNS and immuno-inflammatory mediators are being increasingly linked to progressive brain changes in schizophrenia. Although a significant role of TLR3/TLR4 in neurodegeneration is gaining certainty, their importance in establishing a causal link between prenatal infection and immuno-inflammatory, oxidative and nitrosative stress (IO&NS) responses and influence on adult presentation of schizophrenia is yet to be ascertained. We review here the current knowledge generated from

76 FR 76689 - Cibola National Forest, Mount Taylor Ranger District, NM, Mount Taylor Combined Exploratory Drilling

Science.gov (United States)

2011-12-08

... National Forest, Mount Taylor Ranger District, NM, Mount Taylor Combined Exploratory Drilling AGENCY... proposed action is to approve two Plans of Operations for exploratory uranium drilling on the Cibola... San Mateo. In total, there are up to 279 drill holes that would be drilled over a period not to exceed...

Fibrinogen cleavage products and Toll-like receptor 4 promote the generation of programmed cell death 1 ligand 2-positive dendritic cells in allergic asthma.

Science.gov (United States)

Cho, Minkyoung; Lee, Jeong-Eun; Lim, Hoyong; Shin, Hyun-Woo; Khalmuratova, Roza; Choi, Garam; Kim, Hyuk Soon; Choi, Wahn Soo; Park, Young-Jun; Shim, Inbo; Kim, Byung-Seok; Kang, Chang-Yuil; Kim, Jae-Ouk; Tanaka, Shinya; Kubo, Masato; Chung, Yeonseok

2017-10-14

Inhaled protease allergens preferentially trigger T H 2-mediated inflammation in allergic asthma. The role of dendritic cells (DCs) on induction of T H 2 cell responses in allergic asthma has been well documented; however, the mechanism by which protease allergens induce T H 2-favorable DCs in the airway remains unclear. We sought to determine a subset of DCs responsible for T H 2 cell responses in allergic asthma and the mechanism by which protease allergens induce the DC subset in the airway. Mice were challenged intranasally with protease allergens or fibrinogen cleavage products (FCPs) to induce allergic airway inflammation. DCs isolated from mediastinal lymph nodes were analyzed for surface phenotype and T-cell stimulatory function. Anti-Thy1.2 and Mas-TRECK mice were used to deplete innate lymphoid cells and mast cells, respectively. Adoptive cell transfer, bone marrow DC culture, anti-IL-13, and Toll-like receptor (TLR) 4-deficient mice were used for further mechanistic studies. Protease allergens induced a remarkable accumulation of T H 2-favorable programmed cell death 1 ligand 2 (PD-L2) + DCs in mediastinal lymph nodes, which was significantly abolished in mice depleted of mast cells and, to a lesser extent, innate lymphoid cells. Mechanistically, FCPs generated by protease allergens triggered IL-13 production from wild-type mast cells but not from TLR4-deficient mast cells, which resulted in an increase in the number of PD-L2 + DCs. Intranasal administration of FCPs induced an increase in numbers of PD-L2 + DCs in the airway, which was significantly abolished in TLR4- and mast cell-deficient mice. Injection of IL-13 restored the PD-L2 + DC population in mice lacking mast cells. Our findings unveil the "protease-FCP-TLR4-mast cell-IL-13" axis as a molecular mechanism for generation of T H 2-favorable PD-L2 + DCs in allergic asthma and suggest that targeting the PD-L2 + DC pathway might be effective in suppressing allergic T-cell responses in the airway

DMPD: Glucocorticoids and the innate immune system: crosstalk with the toll-likereceptor signaling network. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17576036 Glucocorticoids and the innate immune system: crosstalk with the toll-like...07 May 13. (.png) (.svg) (.html) (.csml) Show Glucocorticoids and the innate immune system: crosstalk with t...nd the innate immune system: crosstalk with the toll-likereceptor signaling network. Authors Chinenov Y, Rog

Evaluating the extent of cell death in 3D high frequency ultrasound by registration with whole-mount tumor histopathology

International Nuclear Information System (INIS)

Vlad, Roxana M.; Kolios, Michael C.; Moseley, Joanne L.; Czarnota, Gregory J.; Brock, Kristy K.

2010-01-01

Purpose: High frequency ultrasound imaging, 10-30 MHz, has the capability to assess tumor response to radiotherapy in mouse tumors as early as 24 h after treatment administration. The advantage of this technique is that the image contrast is generated by changes in the physical properties of dying cells. Therefore, a subject can be imaged before and multiple times during the treatment without the requirement of injecting specialized contrast agents. This study is motivated by a need to provide metrics of comparison between the volume and localization of cell death, assessed from histology, with the volume and localization of cell death surrogate, assessed as regions with increased echogeneity from ultrasound images. Methods: The mice were exposed to radiation doses of 2, 4, and 8 Gy. Ultrasound images were collected from each tumor before and 24 h after exposure to radiation using a broadband 25 MHz center frequency transducer. After radiotherapy, tumors exhibited hyperechoic regions in ultrasound images that corresponded to areas of cell death in histology. The ultrasound and histological images were rigidly registered. The tumors and regions of cell death were manually outlined on histological images. Similarly, the tumors and hyperechoic regions were outlined on the ultrasound images. Each set of contours was converted to a volumetric mesh in order to compare the volumes and the localization of cell death in histological and ultrasound images. Results: A shrinkage factor of 17±2% was calculated from the difference in the tumor volumes evaluated from histological and ultrasound images. This was used to correct the tumor and cell death volumes assessed from histology. After this correction, the average absolute difference between the volume of cell death assessed from ultrasound and histological images was 11±14% and the volume overlap was 70±12%. Conclusions: The method provided metrics of comparison between the volume of cell death assessed from histology and

The Toll pathway underlies host sexual dimorphism in resistance to both Gram-negative and Gram-positive bacteria in mated Drosophila.

Science.gov (United States)

Duneau, David F; Kondolf, Hannah C; Im, Joo Hyun; Ortiz, Gerardo A; Chow, Christopher; Fox, Michael A; Eugénio, Ana T; Revah, J; Buchon, Nicolas; Lazzaro, Brian P

2017-12-21

Host sexual dimorphism is being increasingly recognized to generate strong differences in the outcome of infectious disease, but the mechanisms underlying immunological differences between males and females remain poorly characterized. Here, we used Drosophila melanogaster to assess and dissect sexual dimorphism in the innate response to systemic bacterial infection. We demonstrated sexual dimorphism in susceptibility to infection by a broad spectrum of Gram-positive and Gram-negative bacteria. We found that both virgin and mated females are more susceptible than mated males to most, but not all, infections. We investigated in more detail the lower resistance of females to infection with Providencia rettgeri, a Gram-negative bacterium that naturally infects D. melanogaster. We found that females have a higher number of phagocytes than males and that ablation of hemocytes does not eliminate the dimorphism in resistance to P. rettgeri, so the observed dimorphism does not stem from differences in the cellular response. The Imd pathway is critical for the production of antimicrobial peptides in response to Gram-negative bacteria, but mutants for Imd signaling continued to exhibit dimorphism even though both sexes showed strongly reduced resistance. Instead, we found that the Toll pathway is responsible for the dimorphism in resistance. The Toll pathway is dimorphic in genome-wide constitutive gene expression and in induced response to infection. Toll signaling is dimorphic in both constitutive signaling and in induced activation in response to P. rettgeri infection. The dimorphism in pathway activation can be specifically attributed to Persephone-mediated immune stimulation, by which the Toll pathway is triggered in response to pathogen-derived virulence factors. We additionally found that, in absence of Toll signaling, males become more susceptible than females to the Gram-positive Enterococcus faecalis. This reversal in susceptibility between male and female Toll

Mounting apparatus for a nozzle guide vane assembly

Science.gov (United States)

Boyd, Gary L.; Shaffer, James E.

1995-01-01

The present invention provides a ceramic nozzle guide assembly with an apparatus for mounting it to a metal nozzle case that includes an intermediate ceramic mounting ring. The mounting ring includes a plurality of projections that are received within a plurality of receptacles formed in the nozzle case. The projections of the mounting ring are secured within the receptacles by a ceramic retainer that allows contact between the two components only along arcuate surfaces thus eliminating sliding contact between the components.

Mounting clips for panel installation

Science.gov (United States)

Cavieres, Andres; Al-Haddad, Tristan; Goodman, Joseph

2017-07-11

A photovoltaic panel mounting clip comprising a base, central indexing tabs, flanges, lateral indexing tabs, and vertical indexing tabs. The mounting clip removably attaches one or more panels to a beam or the like structure, both mechanically and electrically. It provides secure locking of the panels in all directions, while providing guidance in all directions for accurate installation of the panels to the beam or the like structure.

49 CFR 179.10 - Tank mounting.

Science.gov (United States)

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Tank mounting. 179.10 Section 179.10 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... Design Requirements § 179.10 Tank mounting. (a) The manner in which tanks are attached to the car...

Ocean floor mounting of wave energy converters

Science.gov (United States)

Siegel, Stefan G

2015-01-20

A system for mounting a set of wave energy converters in the ocean includes a pole attached to a floor of an ocean and a slider mounted on the pole in a manner that permits the slider to move vertically along the pole and rotate about the pole. The wave energy converters can then be mounted on the slider to allow adjustment of the depth and orientation of the wave energy converters.

Toll-like receptors in the pathogenesis of human B cell malignancies

NARCIS (Netherlands)

Isaza-Correa, Johana M.; Liang, Zheng; van den Berg, Anke; Diepstra, Arjan; Visser, Lydia

2014-01-01

Toll-like receptors (TLRs) are important players in B-cell activation, maturation and memory and may be involved in the pathogenesis of B-cell lymphomas. Accumulating studies show differential expression in this heterogeneous group of cancers. Stimulation with TLR specific ligands, or agonists of

On the Effects of Central Japan Expressway's Commuter Toll Discount Policy in Nagoya Area

Institute of Scientific and Technical Information of China (English)

YING Jiangqian; Ryosuke Ando

2007-01-01

Road pricing policies have two equally important objectives that have to be considered: the optimal use of the road network and the fiscal sustainability for the management of the network. The aim of this work is to examine the effects on these two objectives of a recent pricing policy implemented in Japan's expressway networks. Recently the Nippon (Japan) Expressway Companies (NEXCO, operators of Japan's nation wide expressway network) have implemented several toll discount policies for users equipped with electronic toll collectors (ETCs). One of the policies is the commuter discount policy that discounts 50% for a journey on the NEXCO expressway no longer than 100 km during the commuting peak hours. This paper examines its effect on congestion reduction in the road network of Nagoya area and its influence on the use of expressways operated by another major local public expressway company in Nagoya. The congestion easing effect of this policy is compared with a potential marginal cost pricing scheme. These observations suggest that policy coordination regarding toll levels is needed for expressway corporations and transportation authorities for improving transportation efficiency of utilization of the whole network.

Human Milk Components Modulate Toll-Like Receptor–Mediated Inflammation12

Science.gov (United States)

He, YingYing; Lawlor, Nathan T

2016-01-01

Toll-like receptor (TLR) signaling is central to innate immunity. Aberrant expression of TLRs is found in neonatal inflammatory diseases. Several bioactive components of human milk modulate TLR expression and signaling pathways, including soluble toll-like receptors (sTLRs), soluble cluster of differentiation (sCD) 14, glycoproteins, small peptides, and oligosaccharides. Some milk components, such as sialyl (α2,3) lactose and lacto-N-fucopentaose III, are reported to increase TLR signaling; under some circumstances this might contribute toward immunologic balance. Human milk on the whole is strongly anti-inflammatory, and contains abundant components that depress TLR signaling pathways: sTLR2 and sCD14 inhibit TLR2 signaling; sCD14, lactadherin, lactoferrin, and 2′-fucosyllactose attenuate TLR4 signaling; 3′-galactosyllactose inhibits TLR3 signaling, and β-defensin 2 inhibits TLR7 signaling. Feeding human milk to neonates decreases their risk of sepsis and necrotizing enterocolitis. Thus, the TLR regulatory components found in human milk hold promise as benign oral prophylactic and therapeutic treatments for the many gastrointestinal inflammatory disorders mediated by abnormal TLR signaling. PMID:26773018

Ligands, cell-based models, and readouts required for Toll-like receptor action.

LENUS (Irish Health Repository)

Dellacasagrande, Jerome

2012-02-01

This chapter details the tools that are available to study Toll-like receptor (TLR) biology in vitro. This includes ligands, host cells, and readouts. The use of modified TLRs to circumvent some technical problems is also discussed.

"Split Cast Mounting: Review and New Technique".

Science.gov (United States)

Gundawar, S M; Pande, Neelam A; Jaiswal, Priti; Radke, U M

2014-12-01

For the fabrication of a prosthesis, the Prosthodontist meticulously performs all the steps. The laboratory technician then make every effort/strives to perform the remaining lab procedures. However when the processed dentures are remounted on the articulator, some changes are seen. These changes may be divided into two categories: Pre-insertion and post-insertion changes, which deal with the physical properties of the materials involved (Parker, J Prosthet Dent 31:335-342, 1974). Split cast mounting is the method of mounting casts on the articulator. It is essentially a maxillary cast constructed in two parts with a horizontal division. The procedure allows for the verification of the accuracy of the initial mounting and the ease of removal and replacement of the cast. This provides a precise means of correcting the changes in occlusion occurring as a result of the processing technique (Nogueira et al., J Prosthet Dent 91:386-388, 2004). Instability of the split mounting has always been a problem to the Prosthodontist thereby limiting its use. There are various materials mentioned in the literature. The new technique by using Dowel pins and twill thread is very easy, cheaper and simple way to stabilize the split mounting. It is useful and easy in day to day laboratory procedures. The article presents different methods of split cast mounting and the new procedure using easily available materials in prosthetic laboratory.

Research on LQR optimal control method of active engine mount

Science.gov (United States)

Huan, Xie; Yu, Duan

2018-04-01

In this paper, the LQR control method is applied to the active mount of the engine, and a six-cylinder engine excitation model is established. Through the joint simulation of AMESim and MATLAB, the vibration isolation performance of the active mount system and the passive mount system is analyzed. Excited by the multi-engine operation, the simulation results of the vertical displacement, acceleration and dynamic deflection of the vehicle body show that the vibration isolation capability of the active mount system is superior to that of the passive mount system. It shows that compared with the passive mount, LQR active mount can greatly improve the vibration isolation performance, which proves the feasibility and effectiveness of the LQR control method.

Mounting clips for panel installation

Science.gov (United States)

Cavieres, Andres; Al-Haddad, Tristan; Goodman, Joseph; Valdes, Francisco

2017-02-14

An exemplary mounting clip for removably attaching panels to a supporting structure comprises a base, spring locking clips, a lateral flange, a lever flange, and a spring bonding pad. The spring locking clips extend upwardly from the base. The lateral flange extends upwardly from a first side of the base. The lateral flange comprises a slot having an opening configured to receive at least a portion of one of the one or more panels. The lever flange extends outwardly from the lateral flange. The spring bonding flange extends downwardly from the lever flange. At least a portion of the first spring bonding flange comprises a serrated edge for gouging at least a portion of the one or more panels when the one or more panels are attached to the mounting clip to electrically and mechanically couple the one or more panels to the mounting clip.

[Significance of Toll-like receptors in the pathophysiology of surgical sepsis].

LENUS (Irish Health Repository)

Romics, Laszlo Jr

2012-02-03

The discovery of Toll-like receptors has substantially changed our knowledge of pathogen recognition. 11 Toll-like receptors have so far been described in humans. These recognize distinct pathogen associated molecular patterns, as well as endogenous ligands and small molecular synthetic compounds. TLRs have a multifunctional role in pathogen-triggered immune responses and represent an important connection between the "innate" and "adaptive" immunity. The role of the TLRs in the recognition of pathogens renders them a key figure in the activation of the immune response during surgical sepsis. However, emerging evidence points to a fundamental role in tumorigenesis, transplantation, wound healing, atherogenesis and inflammatory bowel disease. The aim hence was to review experimental data pertaining to the activation of TLR signalling pathways in conditions associated with surgical sepsis. A systematic review of the literature was undertaken by searching the MEDLINE database for the period 1966-2004 without language restriction. The paper also analyses the possible therapeutic utilization of the TLR signalling pathways in surgical sepsis.

Photoelectric panel with equatorial mounting of drive

Science.gov (United States)

Kukhta, M. S.; Krauinsh, P. Y.; Krauinsh, D. P.; Sokolov, A. P.; Mainy, S. B.

2018-03-01

The relevance of the work is determined by the need to create effective models for sunny energy. The article considers a photoelectric panel equipped with a system for tracking the sun. Efficiency of the system is provided by equatorial mounting, which compensates for the rotation of the Earth by rotating the sunny panel in the plane of the celestial equator. The specificity of climatic and geographical conditions of Tomsk is estimated. The dynamics of power variations of photoelectric panels with equatorial mounting during seasonal fluctuations in Tomsk is calculated. A mobile photovoltaic panel with equatorial mounting of the drive has been developed. The methods of design strategy for placing photovoltaic panels in the architectural environment of the city are presented. Key words: sunny energy, photovoltaics, equatorial mounting, mechatronic model, wave reducer, electric drive.

DMPD: When signaling pathways collide: positive and negative regulation of toll-likereceptor signal transduction. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 18631453 When signaling pathways collide: positive and negative regulation of toll-...uction. PubmedID 18631453 Title When signaling pathways collide: positive and neg...l) Show When signaling pathways collide: positive and negative regulation of toll-likereceptor signal transd...likereceptor signal transduction. O'Neill LA. Immunity. 2008 Jul 18;29(1):12-20. (.png) (.svg) (.html) (.csm

Sound Toll Registers Online and the eighteenth century Baltic coffee commerce

NARCIS (Netherlands)

Veluwenkamp, Jan; Draper, Maarten

2014-01-01

The ‘Sound Toll Registers Online’ project of the University of Groningen is the subject of this article. Jan Willem Veluwenkamp and Maarten Draper discuss the history, aims and achievements of the project. The possibilities and prospects of this new source are illustrated by a case study on Baltic

[The controversy of routine articulator mounting in orthodontics].

Science.gov (United States)

Wang, Li; Han, Xianglong; Bai, Ding

2013-06-01

Articulators have been widely used by clinicians of dentistry. But routine articulator mounting is still controversial in orthodontics. Orthodontists oriented by gnathology approve routine articulator mounting while nongnathologic orthodontists disapprove it. This article reviews the thoughts of orthodontist that they agree or disagree with routine articulator mounting based on the considerations of biting, temporomandibular disorder (TMD), periodontitis, and so on.

A lesson from Argentina: Setting transmission tolls in a competitive auction is much better than regulating them

Energy Technology Data Exchange (ETDEWEB)

Galetovic, Alexander [Facultad de Ciencias Economicas y Empresariales, Av. San Carlos de Apoquindo 2200, Santiago (Chile); Inostroza, Juan Ricardo [AES Gener S.A., Sanchez Fontecilla 310, piso 3, Santiago (Chile)

2008-07-15

There are at least two procedures for setting the tolls paid by power line users. One consists of regulating them in a standard process. The other, which is used in Argentina, involves auctioning the lines to the lowest toll. In this paper we show that an auction yields higher expected social welfare if n {>=} 2 bid. Expected social welfare is even higher if, as in Argentina, those who benefit from the line can also bid and build. Moreover, when the social welfare is utilitarian, an auction beats regulation even when the regulator can perfectly audit costs ex post. We describe and examine the auction of the fourth Comahue transmission line in Argentina. Assuming that the regulator's information about costs is similar to the information held by the industry, the model suggests that had tolls been regulated, they would have been at least 61% higher. (author)

An electrochemical lipopolysaccharide sensor based on an immobilized Toll-Like Receptor-4.

Science.gov (United States)

Mayall, R M; Renaud-Young, M; Chan, N W C; Birss, V I

2017-01-15

Infections affect millions of people each year and yet methods to ascertain their cause can take more than 24h to be effective. This delay between the presentation with symptoms and the ability to make an informed decision about treatment can have adverse consequences, including death in severe cases. Additionally, pathogen identification is a concern for public safety amid the growing threat of bioterrorism. Developing a detection system based on the immune system offers the advantage of broad specificity, while still remaining pertinent to human health. In this work, human Toll-Like Receptor-4 (TLR-4), a protein responsible for detecting lipopolysaccharide (LPS) of Gram-negative bacteria, was immobilized on both a large area and micro gold electrode via the tethering interaction of a modified Self-Assembled Monolayer (mSAM). In response to varying concentrations of its target, the protein-electrode combination showed a logarithmically proportional increased resistance to charge transfer from a solution-based redox probe, due to the formation of TLR-4 protein dimers. It also demonstrated excellent sensitivity to trace levels of Gram-negative bacteria, while remaining insensitive to both Gram-positive and viral challenges. Further characterization of our mSAM revealed that maintaining the appropriate receptor orientation on the electrode surface, mimicking TLR-4's role in a cellular context, was essential in producing a responsive sensor. Copyright © 2016 Elsevier B.V. All rights reserved.

Development of a Double Glass Mounting Method Using Formaldehyde Alcohol Azocarmine Lactophenol (FAAL) and its Evaluation for Permanent Mounting of Small Nematodes.

Science.gov (United States)

Zahabiun, Farzaneh; Sadjjadi, Seyed Mahmoud; Esfandiari, Farideh

2015-01-01

Permanent slide preparation of nematodes especially small ones is time consuming, difficult and they become scarious margins. Regarding this problem, a modified double glass mounting method was developed and compared with classic method. A total of 209 nematode samples from human and animal origin were fixed and stained with Formaldehyde Alcohol Azocarmine Lactophenol (FAAL) followed by double glass mounting and classic dehydration method using Canada balsam as their mounting media. The slides were evaluated in different dates and times, more than four years. Different photos were made with different magnification during the evaluation time. The double glass mounting method was stable during this time and comparable with classic method. There were no changes in morphologic structures of nematodes using double glass mounting method with well-defined and clear differentiation between different organs of nematodes in this method. Using this method is cost effective and fast for mounting of small nematodes comparing to classic method.

MECHANISMS OF ANTIINFECTIOUS FUNCTIONS OF INNATE IMMUNITY: ROLE OF TOLL-LIKE RECEPTORS

Directory of Open Access Journals (Sweden)

S. I. Suskov

2012-01-01

Full Text Available This review describes the main role of toll-like receptors of innate immunity for pathogen recognition; signaling; production of inflammatory response. Also Interrelation of innate and adaptive Immunity in conditions of pathology and organ transplantation were considered. 

Trial Watch: Immunogenic cell death inducers for anticancer chemotherapy.

Science.gov (United States)

Pol, Jonathan; Vacchelli, Erika; Aranda, Fernando; Castoldi, Francesca; Eggermont, Alexander; Cremer, Isabelle; Sautès-Fridman, Catherine; Fucikova, Jitka; Galon, Jérôme; Spisek, Radek; Tartour, Eric; Zitvogel, Laurence; Kroemer, Guido; Galluzzi, Lorenzo

2015-04-01

The term "immunogenic cell death" (ICD) is now employed to indicate a functionally peculiar form of apoptosis that is sufficient for immunocompetent hosts to mount an adaptive immune response against dead cell-associated antigens. Several drugs have been ascribed with the ability to provoke ICD when employed as standalone therapeutic interventions. These include various chemotherapeutics routinely employed in the clinic (e.g., doxorubicin, epirubicin, idarubicin, mitoxantrone, bleomycin, bortezomib, cyclophosphamide and oxaliplatin) as well as some anticancer agents that are still under preclinical or clinical development (e.g., some microtubular inhibitors of the epothilone family). In addition, a few drugs are able to convert otherwise non-immunogenic instances of cell death into bona fide ICD, and may therefore be employed as chemotherapeutic adjuvants within combinatorial regimens. This is the case of cardiac glycosides, like digoxin and digitoxin, and zoledronic acid. Here, we discuss recent developments on anticancer chemotherapy based on ICD inducers.

Combating Drug Abuse by Targeting Toll-Like Receptor 4 (TLR)

Science.gov (United States)

2015-12-01

the treatment of addiction . 2. Keywords Drug reward Addiction Opioid Morphine Heroine Cocaine Dopamine Mesolimbic dopamine pathway...there is some other less selective explanation for this phenomenon. Current pharmacological treatments for opioid addiction /abuse tend to be only...toll like receptor 4 in both opioid and cocaine reward / reinforcement. In addition it has successfully documented the potential of (+)naltrexone (a

Improved resolution by mounting of tissue sections for laser microdissection.

Science.gov (United States)

van Dijk, M C R F; Rombout, P D M; Dijkman, H B P M; Ruiter, D J; Bernsen, M R

2003-08-01

Laser microbeam microdissection has greatly facilitated the procurement of specific cell populations from tissue sections. However, the fact that a coverslip is not used means that the morphology of the tissue sections is often poor. To develop a mounting method that greatly improves the morphological quality of tissue sections for laser microbeam microdissection purposes so that the identification of target cells can be facilitated. Fresh frozen tissue and formalin fixed, paraffin wax embedded tissue specimens were used to test the morphological quality of mounted and unmounted tissue. The mounting solution consisted of an adhesive gum and blue ink diluted in water. Interference of the mounting solution with DNA quality was analysed by the polymerase chain reaction using 10-2000 cells isolated by microdissection from mounted and unmounted tissue. The mounting solution greatly improved the morphology of tissue sections for laser microdissection purposes and had no detrimental effects on the isolation and efficiency of amplification of DNA. One disadvantage was that the mounting solution reduced the cutting efficiency of the ultraviolet laser. To minimise this effect, the mounting solution should be diluted as much as possible. Furthermore, the addition of blue ink to the mounting medium restores the cutting efficiency of the laser. The mounting solution is easy to prepare and apply and can be combined with various staining methods without compromising the quality of the DNA extracted.

Reptile Toll-like receptor 5 unveils adaptive evolution of bacterial flagellin recognition

NARCIS (Netherlands)

Voogdt, Carlos G P|info:eu-repo/dai/nl/413535169; Bouwman, Lieneke I|info:eu-repo/dai/nl/341590797; Kik, Marja J L|info:eu-repo/dai/nl/080432565; Wagenaar, Jaap A|info:eu-repo/dai/nl/126613354; van Putten, Jos P M|info:eu-repo/dai/nl/069916527

2016-01-01

Toll-like receptors (TLR) are ancient innate immune receptors crucial for immune homeostasis and protection against infection. TLRs are present in mammals, birds, amphibians and fish but have not been functionally characterized in reptiles despite the central position of this animal class in

Exploitation of the Toll-like receptor system in cancer: a doubled-edged sword?

LENUS (Irish Health Repository)

Killeen, S D

2012-02-03

The toll-like receptor (TLR) system constitutes a pylogenetically ancient, evolutionary conserved, archetypal pattern recognition system, which underpins pathogen recognition by and activation of the immune system. Toll-like receptor agonists have long been used as immunoadjuvants in anti cancer immunotherapy. However, TLRs are increasingly implicated in human disease pathogenesis and an expanding body of both clinical and experimental evidence suggests that the neoplastic process may subvert TLR signalling pathways to advance cancer progression. Recent discoveries in the TLR system open a multitude of potential therapeutic avenues. Extrapolation of such TLR system manipulations to a clinical oncological setting demands care to prevent potentially deleterious activation of TLR-mediated survival pathways. Thus, the TLR system is a double-edge sword, which needs to be carefully wielded in the setting of neoplastic disease.

Toll-Like Receptors in the Pathogenesis of Autoimmune Diseases

OpenAIRE

Mohammad Hosseini, Akbar; Majidi, Jafar; Baradaran, Behzad; Yousefi, Mehdi

2015-01-01

Human Toll-like receptors (TLRs) are a family of transmembrane receptors, which play a key role in both innate and adaptive immune responses. Beside of recognizing specific molecular patterns that associated with different types of pathogens, TLRs may also detect a number of self-proteins and endogenous nucleic acids. Activating TLRs lead to the heightened expression of various inflammatory genes, which have a protective role against infection. Data rising predominantly from human patients an...

Opioid prescriptions for pain and epidemic of overdose death: can the dramatic reduction in anesthesia mortality serve as an example?

Directory of Open Access Journals (Sweden)

Kissin I

2016-06-01

Full Text Available Igor Kissin Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA Abstract: The annual number of US deaths from prescription-opioid overdose quadrupled between 1999 and 2010 and in 2010 alone reached 16,651. Deaths from opioid overdose have now surpassed the historic death toll from another drug-related epidemic – anesthesia mortality. In 1954, Beecher and Todd published reliable data on anesthesia-related mortality in the US, estimating the annual number of deaths to be nearly 5,000. Presently anesthesia/anesthetics are reported as the underlying cause in approximately 34 deaths in the US annually. This spectacular decline in anesthesia-related mortality could serve as an example for attempts to curb the epidemic of opioid overdose death. The main reason that led to the dramatic decline in anesthesia-related mortality is the context in which anesthetics are used. It includes training of the anesthesia providers, the introduction of specific standards of patient safety, and anesthesia monitoring. I suggest that the introduction of a similar multifactorial proper context for the use of opioids in the treatment of chronic nonmalignant pain might be the same “game changer” it was for safety in anesthesia. Keywords: chronic pain, addiction, opioid-use disorder, treatment compliance, apprenticeship, metrics of opioid effectiveness, aberrant opioid-related behavior

Isolation Mounting for Charge-Coupled Devices

Science.gov (United States)

Goss, W. C.; Salomon, P. M.

1985-01-01

CCD's suspended by wires under tension. Remote thermoelectric cooling of charge coupled device allows vibration isolating mounting of CCD assembly alone, without having to suspend entire mass and bulk of thermoelectric module. Mounting hardware simple and light. Developed for charge-coupled devices (CCD's) in infrared telescope support adaptable to sensors in variety of environments, e.g., sensors in nuclear reactors, engine exhausts and plasma chambers.

Flow distortion on boom mounted cup anemometers

DEFF Research Database (Denmark)

Lindelöw, Per Jonas Petter; Friis Pedersen, Troels; Gottschall, Julia

In this report we investigate on wind direction dependent errors in the measurement of the horizontal wind speed by boom mounted cup anemometers. The boom mounting on the studied lattice tower is performed according to IEC standard design rules, yet, larger deviations than predicted by flow models...... are observed. The errors on the measurements are likely caused by an underestimation of the flow distortions around the tower. In this paper an experimental method for deriving a correction formula and an in-field calibration is suggested. The method is based on measurements with two cup anemometers mounted...

Toll-Like Receptors and Myocardial Inflammation

Directory of Open Access Journals (Sweden)

Yan Feng

2011-01-01

Full Text Available Toll-like receptors (TLRs are a member of the innate immune system. TLRs detect invading pathogens through the pathogen-associated molecular patterns (PAMPs recognition and play an essential role in the host defense. TLRs can also sense a large number of endogenous molecules with the damage-associated molecular patterns (DAMPs that are produced under various injurious conditions. Animal studies of the last decade have demonstrated that TLR signaling contributes to the pathogenesis of the critical cardiac conditions, where myocardial inflammation plays a prominent role, such as ischemic myocardial injury, myocarditis, and septic cardiomyopathy. This paper reviews the animal data on (1 TLRs, TLR ligands, and the signal transduction system and (2 the important role of TLR signaling in these critical cardiac conditions.

Reptile Toll-like receptor 5 unveils adaptive evolution of bacterial flagellin recognition

NARCIS (Netherlands)

Voogdt, Carlos G.P.; Bouwman, Lieneke I.; Kik, Marja J.L.; Wagenaar, Jaap A.; Putten, Van Jos P.M.

2016-01-01

Toll-like receptors (TLR) are ancient innate immune receptors crucial for immune homeostasis and protection against infection. TLRs are present in mammals, birds, amphibians and fish but have not been functionally characterized in reptiles despite the central position of this animal class in

Investigation of the feasibility of toll and transit agency equity sharing : white paper.

Science.gov (United States)

2010-04-12

This research project frames the institutional constraints and opportunities for equity sharing that currently exist in the highway, transit and toll agency realms and identifies statutory, regulatory and/or policy changes that may be requried. It al...

Transducer-Mounting Fixture

Science.gov (United States)

Spiegel, Kirk W.

1990-01-01

Transducer-mounting fixture holds transducer securely against stud. Projects only slightly beyond stud after installation. Flanged transducer fits into fixture when hinged halves open. When halves reclosed, fixture tightened onto threaded stud until stud makes contact with transducer. Knurled area on fixture aids in tightening fixture on stud.

Identification of potential pathway mediation targets in Toll-like receptor signaling.

Directory of Open Access Journals (Sweden)

Fan Li

2009-02-01

Full Text Available Recent advances in reconstruction and analytical methods for signaling networks have spurred the development of large-scale models that incorporate fully functional and biologically relevant features. An extended reconstruction of the human Toll-like receptor signaling network is presented herein. This reconstruction contains an extensive complement of kinases, phosphatases, and other associated proteins that mediate the signaling cascade along with a delineation of their associated chemical reactions. A computational framework based on the methods of large-scale convex analysis was developed and applied to this network to characterize input-output relationships. The input-output relationships enabled significant modularization of the network into ten pathways. The analysis identified potential candidates for inhibitory mediation of TLR signaling with respect to their specificity and potency. Subsequently, we were able to identify eight novel inhibition targets through constraint-based modeling methods. The results of this study are expected to yield meaningful avenues for further research in the task of mediating the Toll-like receptor signaling network and its effects.

Death and Death Anxiety

OpenAIRE

Gonca Karakus; Zehra Ozturk; Lut Tamam

2012-01-01

Although death and life concepts seem so different from each other, some believe that death and life as a whole that death is accepted as the goal of life and death completes life. In different cultures, societies and disciplines, there have been very different definitions of death which changes according to personality, age, religion and cultural status of the individual. Attitudes towards death vary dramatically according to individuals. As for the death anxiety, it is a feeling which start...

Substantiation of the road toll for heavy transport vehicles

OpenAIRE

Burmaka, N.; Chernykh, A.

2010-01-01

The existing and possible additional sources of developing state and local road funds of Ukraine have been considered. The formula for calculating monthly road toll for heavy transport vehicles has been proposed. This formula includes the payment rate per every kilometer of distance, the vehicle capacity utilization factor and the run with the load. The payment rate per every kilometer of distance for transport vehicles depending on the allowed total weight has been substantiated. The given r...

49 CFR 571.212 - Standard No. 212; Windshield mounting.

Science.gov (United States)

2010-10-01

... 49 Transportation 6 2010-10-01 2010-10-01 false Standard No. 212; Windshield mounting. 571.212... Motor Vehicle Safety Standards § 571.212 Standard No. 212; Windshield mounting. S1. Scope. This standard..., under the conditions of S6, the windshield mounting of the vehicle shall retain not less than the...

47 CFR 43.53 - Reports regarding division of international toll communication charges.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Reports regarding division of international... AFFILIATES § 43.53 Reports regarding division of international toll communication charges. (a) Each... between the continental United States and any foreign country (other than one to which the domestic word...

New active machine tool drive mounting on the frame

Directory of Open Access Journals (Sweden)

Švéda J.

2007-10-01

Full Text Available The paper deals with the new active mounting of the machine tool drives. The commonly used machine tools are at this time mainly equipped with fix-mounting of the feed drives. This structure causes full transmission of the force shocks to the machine bed and thereby restricts the dynamic properties of the motion axis and the whole machine. The spring-mounting of the feed drives is one of the possibilities how to partially suppress the vibrations. The force that reacts to the machine tool bed is transformed thereby the vibrations are lightly reduced. Unfortunately the transformation is not fully controlled. The new active mounting of the machine tool drives allows to fully control the force behaviour that react to the machine body. Thereby the number of excited frequencies on the machine tool bed is significantly reduced. The active variant of the feed drive mounting is characterized by the synergistic cooperation between two series-connected actuators (“motor on motor”. The paper briefly describes design, control techniques and optimization of the feed drives with the new active mounting conception.

Activation of toll-like receptors 2 and 4 by gram-negative periodontal bacteria

NARCIS (Netherlands)

Kikkert, R.; Laine, M. L.; Aarden, L. A.; van Winkelhoff, A. J.

2007-01-01

BACKGROUND/AIMS: Periodontitis is a chronic infectious disease associated with a gram-negative subgingival microflora. Bacterial components stimulate, among other receptors, Toll-like receptor (TLR) 2 and/or TLR4. Accumulating evidence indicates that both qualitatively and quantitatively distinct

Local Community Entrepreneurship in Mount Agung Trekking

Science.gov (United States)

Mudana, I. G.; Sutama, I. K.; Widhari, C. I. S.

2018-01-01

Since its last major eruption in 1963, Mount Agung in Selat District, Karangasem Regency, the highest mountain in Bali Province began to be visited by tourists climbers. Because of the informal obligation that every climbing/trekking should be guided by local guides, since the 1990s, there have been initiatives from a number of local community members to serve climbing tourists who were keen to climb the volcano/mountain. This study was conducted to understand and describe the entrepreneurial practices which appeared in the local surrounding community. Specifically, Selat Village, in guiding the climbing/trekking. This study used qualitative data analysis and its theories were adapted to data needed in the field. The results of study showed that Mount Agung was considered attractive by climbing tourists not only because of the exotic beauty and challenges of difficulty (as well as the level of danger) to conquer it, but also because it kept certain myths from its status as a holy/sacred mountain to Balinese Hindus. In fact, a number of tourists who did the climbing/trekking without being guided very often got lost, harmed in an accident, or fell to their death. As a direct result, all climbing activities require guidance. Especially guides from local community organizations who really understand the intricacies of climbing and the curvature of the mountain. The entrepreneurial practices of Selat Village community had arisen not only to serve usual climbing activities, but also to preserve the environment of the mountain and the safety of the climbing tourists with the many taboos related to the climb. These facts could be seen clearly from descriptions of local experts and local climbing guides who have been doing their work for years. As a form of entrepreneurship, they basically did their work for the main purpose of seeking livelihoods (or making money) but their responsibility as local people made them commit to guarding the sanctity of the mountain. This was

Mycobacterium avium MAV2052 protein induces apoptosis in murine macrophage cells through Toll-like receptor 4.

Science.gov (United States)

Lee, Kang-In; Choi, Han-Gyu; Son, Yeo-Jin; Whang, Jake; Kim, Kwangwook; Jeon, Heat Sal; Park, Hye-Soo; Back, Yong Woo; Choi, Seunga; Kim, Seong-Woo; Choi, Chul Hee; Kim, Hwa-Jung

2016-04-01

Mycobacterium avium and its sonic extracts induce apoptosis in macrophages. However, little is known about the M. avium components regulating macrophage apoptosis. In this study, using multidimensional fractionation, we identified MAV2052 protein, which induced macrophage apoptosis in M. avium culture filtrates. The recombinant MAV2052 induced macrophage apoptosis in a caspase-dependent manner. The loss of mitochondrial transmembrane potential (ΔΨm), mitochondrial translocation of Bax, and release of cytochrome c from mitochondria were observed in macrophages treated with MAV2052. Further, reactive oxygen species (ROS) production was required for the apoptosis induced by MAV2052. In addition, ROS and mitogen-activated protein kinases were involved in MAV2052-mediated TNF-α and IL-6 production. ROS-mediated activation of apoptosis signal-regulating kinase 1 (ASK1)-JNK pathway was a major signaling pathway for MAV2052-induced apoptosis. Moreover, MAV2052 bound to Toll-like receptor (TLR) 4 molecule and MAV2052-induced ROS production, ΔΨm loss, and apoptosis were all significantly reduced in TLR4(-/-) macrophages. Altogether, our results suggest that MAV2052 induces apoptotic cell death through TLR4 dependent ROS production and JNK pathway in murine macrophages.

Organization and processes of the BN-600 reactor mounting

International Nuclear Information System (INIS)

Dubrovin, E.Z.; Karpenko, V.N.; Takhtaulov, V.M.

1982-01-01

Structural peculiarities of the BN-600 reactor plant are considered. Experience of metal structure mounting inside the reactor vessel has been analysed. Recommendations on the improvements on the organization of the thermal mechanical equipment mounting are given. It is concluded that the consideration of these recommendations will permit to reduce expenditures of labour by 10-40% for the mounting

46 CFR 61.05-15 - Boiler mountings and attachments.

Science.gov (United States)

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Boiler mountings and attachments. 61.05-15 Section 61.05... TESTS AND INSPECTIONS Tests and Inspections of Boilers § 61.05-15 Boiler mountings and attachments. (a....05-10. (b) Each stud or bolt for each boiler mounting that paragraph (c) of this section requires to...

Global earthquake fatalities and population

Science.gov (United States)

Holzer, Thomas L.; Savage, James C.

2013-01-01

Modern global earthquake fatalities can be separated into two components: (1) fatalities from an approximately constant annual background rate that is independent of world population growth and (2) fatalities caused by earthquakes with large human death tolls, the frequency of which is dependent on world population. Earthquakes with death tolls greater than 100,000 (and 50,000) have increased with world population and obey a nonstationary Poisson distribution with rate proportional to population. We predict that the number of earthquakes with death tolls greater than 100,000 (50,000) will increase in the 21st century to 8.7±3.3 (20.5±4.3) from 4 (7) observed in the 20th century if world population reaches 10.1 billion in 2100. Combining fatalities caused by the background rate with fatalities caused by catastrophic earthquakes (>100,000 fatalities) indicates global fatalities in the 21st century will be 2.57±0.64 million if the average post-1900 death toll for catastrophic earthquakes (193,000) is assumed.

Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

Science.gov (United States)

Chronic low-grade inflammation is a hallmark of obesity and thought to contribute to the development of obesity-related insulin resistance. Toll-like receptor 4 (Tlr4) is a key mediator of pro-inflammatory responses. Mice lacking Tlr4s are protected from diet-induced insulin resistance and inflammat...

Role of toll like receptors in bacterial and viral diseases – A ...

African Journals Online (AJOL)

Avishek Das

2017-05-20

May 20, 2017 ... Cellular Immunology Laboratory, Department of Zoology, University of North ... Background: Toll like receptors are key-receptors of the innate immune ...... Triggering TLR7 in mice induces immune activation and lymphoid.

Linear and/or curvilinear rail mount system

Science.gov (United States)

Thomas, Jackie D. (Inventor); Harris, Lawanna L. (Inventor)

2012-01-01

One or more linear and/or curvilinear mounting rails are coupled to a structure. Each mounting rail defines a channel and at least one cartridge assembly is engaged in the channel. Each cartridge assembly includes a housing that slides within the channel. The housing defines a curvilinearly-shaped recess longitudinally aligned with the channel when the housing is in engagement therewith. The cartridge assembly also includes a cleat fitted in the recess for sliding engagement therealong. The cleat can be coupled to a fastener that passes through the mounting rail and the housing when the housing is so-engaged in the channel. The cleat is positioned in the recess by a position of the fastener.

Methods and apparatus for radially compliant component mounting

Science.gov (United States)

Bulman, David Edward [Cincinnati, OH; Darkins, Jr., Toby George; Stumpf, James Anthony [Columbus, IN; Schroder, Mark S [Greenville, SC; Lipinski, John Joseph [Simpsonville, SC

2012-03-27

Methods and apparatus for a mounting assembly for a liner of a gas turbine engine combustor are provided. The combustor includes a combustor liner and a radially outer annular flow sleeve. The mounting assembly includes an inner ring surrounding a radially outer surface of the liner and including a plurality of axially extending fingers. The mounting assembly also includes a radially outer ring coupled to the inner ring through a plurality of spacers that extend radially from a radially outer surface of the inner ring to the outer ring.

Antecedents Varıables of Intentıon to Use Servıce Innovatıon: An Empırıcal Study of E-Toll Card

Directory of Open Access Journals (Sweden)

Aldio Pramudya Gunadi

2015-09-01

Full Text Available Lack of consumer willingness to adopt electronic toll card in Jakarta triger the congestion at the toll gates. This congestion has been one of the critical factors that needs to be more focused by PT Jasa Marga as  highway toll service company. The fact shows that only 5.88% of all the total transactions in the toll gates applied E-toll card facility. These facts provide evidence about the lack of consumer willingness to adopt E-Toll card. Therefore, the understanding of consumer behavior to adopt sevice innovation is necessary to solve these lack of consumer unwillingness. This study was developed by replicated the research of Lee (2012 that reveal the antecedents factors that affect the consumer intention to adopt service innovation. Respondents of this research were 217 students from a private university in Tangerang. Respondent were collected by using judgemental sampling based on their experience in using E-toll card. The survey instrument employed demographic background, consumer attitude, perceived ease of use, perceived price fairness, satisfaction with existing service, fashion consciousness, risk averseness and consumer intention to adopt service innovation. Structural equation modeling (SEM was applied to analyze the data. Result indicated that consumer attitude, perceived ease of use, satisfaction with existing service, risk averseness, and fashion consciousness are the predictors of consumer intention to adopt service innovation. This research also provides the theoretical implication, managerial implication, and suggestion for future research.

Vertical repositioning accuracy of magnetic mounting systems on 4 articulator models.

Science.gov (United States)

Lee, Wonsup; Kwon, Ho-Beom

2018-03-01

Research of the ability of a cast mounted on an articulator on maintaining the identical position of a cast mounted on an articulator after repeated repositioning is lacking, despite the possible effects this may have on the occlusion of a mounted cast. The purpose of this in vitro study was to verify and compare the vertical repositioning accuracy of 4 different, commercially available articulator magnetic mounting plate systems. Four articulators and their associated magnetic mounting plates were selected for the study. These were the Artex AR articulator (Amann Girrbach AG), the Denar Mark II articulator (Whip Mix Corp), the Kavo Protar Evo articulator (Kavo Dental GmbH), and the SAM3 articulator (SAM Präzisionstechnik GmbH). Three new magnetic mounting plates were prepared for each articulator system. The repositioning accuracy of each mounting plate was evaluated by comparing the standard deviation of the vertical distances measured between the mounting plate and a laser displacement sensor. The lower arm of the articulator was secured, and the vertical distance was measured by positioning the laser displacement sensor positioned vertically above the mounting plate. Once the vertical distance was measured, the mounting plate was detached from the articulator and reattached manually to prepare for the next measurement. This procedure was repeated 30 times for each of the 3 magnetic mounting plates. Data were analyzed by ANOVA for 2-stage nested design and the Levene test (α=.05). Significant differences were detected among articulator systems and between magnetic mounting plates of the same type. The standard deviations of the measurements made with the Artex AR articulator, Denar Mark II articulator, Kavo Protar Evo articulator, and SAM3 articulator were 0.0027, 0.0308, 0.0214, and 0.0215 mm, respectively. Thus, the repositioning accuracy could be ranked in the order as follows: Artex AR, Kavo Protar Evo, SAM3, and Denar Mark II. The position of the

Internally Mounting Strain Gages

Science.gov (United States)

Jett, J. R., Jr.

1984-01-01

Technique for mounting strain gages inside bolt or cylinder simultaneously inserts gage, attached dowel segment, and length of expandable tubing. Expandable tubing holds gage in place while adhesive cures, assuring even distribution of pressure on gage and area gaged.

Application of Evolutionary Computation in Automotive Powertrain Mount Tuning

Directory of Open Access Journals (Sweden)

Anab Akanda

2006-01-01

Full Text Available Engine mount tuning is a multi-disciplinary exercise since it affects Idle-shake, Road-shake and power-train noise response. Engine inertia is often used as a tuned absorber for controlling suspension resonance related road-shake issues. Last but not least, vehicle ride and handling may also be affected by mount tuning. In this work, Torque-Roll-Axis (TRA decoupling of the rigid powertrain was used as a starting point for mount tuning. Nodal point of flexible powertrain bending was used to define the envelop for transmission mount locations. The frequency corresponding to the decoupled roll mode of the rigid powertrain was then adjusted for idle-shake and road-shake response management.

Sleep deprivation and divergent toll-like receptor-4 activation of cellular inflammation in aging.

Science.gov (United States)

Carroll, Judith E; Carrillo, Carmen; Olmstead, Richard; Witarama, Tuff; Breen, Elizabeth C; Yokomizo, Megumi; Seeman, Teresa; Irwin, Michael R

2015-02-01

Sleep disturbance and aging are associated with increases in inflammation, as well as increased risk of infectious disease. However, there is limited understanding of the role of sleep loss on age-related differences in immune responses. This study examines the effects of sleep deprivation on toll-like receptor activation of monocytic inflammation in younger compared to older adults. Community-dwelling adults (n = 70) who were categorized as younger (25-39 y old, n = 21) and older (60-84 y old, n = 49) participants, underwent a sleep laboratory-based experimental partial sleep deprivation (PSD) protocol including adaptation, an uninterrupted night of sleep, sleep deprivation (sleep restricted to 03:00-07:00), and recovery. Blood samples were obtained each morning to measure toll-like receptor-4 activation of monocyte intracellular production of the inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Partial sleep deprivation induced a significant increase in the production of IL-6 and/or TNF-α that persisted after a night of recovery sleep (F(2,121.2) = 3.8, P sleep loss, such that younger adults had an increase in inflammatory cytokine production that was not present in older adults (F(2,121.2) = 4.0, P sleep loss. Whereas sleep loss increases cellular inflammation in younger adults and may contribute to inflammatory disorders, blunted toll-like receptor activation in older adults may increase the risk of infectious disease seen with aging. © 2015 Associated Professional Sleep Societies, LLC.

Flat mount preparation for observation and analysis of zebrafish embryo specimens stained by whole mount in situ hybridization.

Science.gov (United States)

Cheng, Christina N; Li, Yue; Marra, Amanda N; Verdun, Valerie; Wingert, Rebecca A

2014-07-17

The zebrafish embryo is now commonly used for basic and biomedical research to investigate the genetic control of developmental processes and to model congenital abnormalities. During the first day of life, the zebrafish embryo progresses through many developmental stages including fertilization, cleavage, gastrulation, segmentation, and the organogenesis of structures such as the kidney, heart, and central nervous system. The anatomy of a young zebrafish embryo presents several challenges for the visualization and analysis of the tissues involved in many of these events because the embryo develops in association with a round yolk mass. Thus, for accurate analysis and imaging of experimental phenotypes in fixed embryonic specimens between the tailbud and 20 somite stage (10 and 19 hours post fertilization (hpf), respectively), such as those stained using whole mount in situ hybridization (WISH), it is often desirable to remove the embryo from the yolk ball and to position it flat on a glass slide. However, performing a flat mount procedure can be tedious. Therefore, successful and efficient flat mount preparation is greatly facilitated through the visual demonstration of the dissection technique, and also helped by using reagents that assist in optimal tissue handling. Here, we provide our WISH protocol for one or two-color detection of gene expression in the zebrafish embryo, and demonstrate how the flat mounting procedure can be performed on this example of a stained fixed specimen. This flat mounting protocol is broadly applicable to the study of many embryonic structures that emerge during early zebrafish development, and can be implemented in conjunction with other staining methods performed on fixed embryo samples.

Stimulation of Toll-like receptor-1/2 combined with Velcade increases cytotoxicity to human multiple myeloma cells

International Nuclear Information System (INIS)

Abdi, J; Mutis, T; Garssen, J; Redegeld, F

2013-01-01

An increasing body of evidence supports the important role of adhesion to bone marrow microenvironment components for survival and drug resistance of multiple myeloma (MM) cells. Previous studies suggested that stimulation of Toll-like receptors by endogenous ligands released during inflammation and tissue damage may be pro-tumorigenic, but no studies have been performed in relation to modulation of cell adhesion and drug cytotoxicity. Here, we investigated the effect of TLR1/2 activation on adhesion of human myeloma cells to fibronectin, and their sensitivity to the proteasome inhibitor Velcade. It was found that TLR1/2 activation with Pam3CSK4 increased the cytotoxicity of Velcade in L363, OPM-2 and U266 human myeloma cells. This effect was not related to a decreased adhesion of the cells to fibronectin, but TLR1/2 activation stimulated the caspase-3 activity in Velcade-treated myeloma cells, which may be responsible for the enhanced cell death. Inhibitors of NF-κB and MAPK reduced the stimulatory effect. These findings indicate that TLR activation of MM cells could bypass protective effects of cell adhesion and suggest that TLR signaling may also have antitumorigenic potential

Synthesis and evaluation of peptide and nucleic acid based Toll-like receptor ligands

NARCIS (Netherlands)

Weterings, Josephus Johannes

2008-01-01

Toll-like receptors (TLRs) are receptors that continuously scour their direct surroundings for pathogen associated molecular patterns (PAMPs) of bacterial, viral or fungal origin. TLRs can be found at cells that play a role in the immune system. Binding of the TLR with its corresponding ligand

UHV mirror mounts for photophysics beamline at Indus-I

International Nuclear Information System (INIS)

Meenakshi Raja Rao, P.; Bhattacharya, S.S.; Das, N.C.; Rajasekhar, B.N.; Roy, A.P.

1995-01-01

Photophysics beamline makes use of a combination of two toroidal mirrors and one meter Seya-Namioka Monochromator in its fore optics. The fore optics monochromatises and steers the synchrotron radiation source (SRS) beam from its tangent point to the sample situated at a distance of about five meters. Slit widths of the monochromator are of the order of 100μ and the sample size is one mm 2 . Hence it is essential to impart precision rotational and translational movements of the same order of magnitude to the mirrors with the use of appropriate mirror mounts. Since Indus-1 operates at a pressure -9 mbar, the mirror mounts should be UHV compatible and the movements should be actuated under UHV. The mirrors along with the mirror mounts are enclosed in UHV chambers. The mirror chambers have been fabricated at Centre for Advanced Technology (CAT) workshops and tested up to a pressure of 10 -9 mbar. The mirror mounts are designed, fabricated and leak checked (He leak rate -10 std cc/s) The precision movements are achieved with the help of bellow sealed shaft mechanism and adjustable screws provided with the kinematic mount of the mirror frame. The performance of the mirror mount was tested at atmospheric pressure by using a laser beam and found to be good. The minimum displacement of the laser beam at slit and sample positions is ∼ 70μ which is quite adequate for optical alignment. The performance of the mirror mount under UHV conditions is being evaluated. (author). 4 refs., 3 figs

Placental Trophoblast Responses to Porphyromonas gingivalis Mediated by Toll-like Receptor-2 and -4

Directory of Open Access Journals (Sweden)

Banun Kusumawardani

2013-09-01

Full Text Available Trophoblast participates in preventing allorecognition and controlling pathogens that compromise fetal wellbeing. Toll-like receptors recognize conserved sequences on the pathogens surface and trigger effector cell functions. Porphyromonas gingivalis is thought to spread to the umbilical cord and cause fetal growth restriction. Objective: To characterize expression and function of TLR-2 and TLR-4 in trophoblast cells from Porphyromonas gingivalisinfected pregnant rats. Methods: Live Porphyromonas gingivalis were challenged into the maxillary first molar subgingival sulcus of female rats before and/or during pregnancy and sacrified on gestational day (GD 14 and 20. Porphyromonas gingivalis was detected by API-ZYM system in the maternal blood of the retro-orbital venous plexus and the umbilical cord. TLR-2 and TLR-4 expressions in trophoblast cells was detected by immunohistochemistry. Results: Porphyromonas gingivalis was first detected in the maternal blood and finally spread to the umbilical cord. Syncytiotrophoblast, spongitrophoblast and trophoblastic giant cell in treated groups had significantly higher expression of TLR-2 and TLR-4 than control group (p<0.05. Conclusion: Syncytiotrophoblast, spongitrophoblast and trophoblastic giant cell are able to recognize Porphyromonas gingivalis through TLR-2 and TLR-4 expression. The ligation of TLR-2 and TLR-4 promoted cytokine production and induced trophoblast cell death. These findings strengthen links between periodontal disease and fetal growth restriction.DOI: 10.14693/jdi.v20i2.150

First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds

Czech Academy of Sciences Publication Activity Database

Bainová, H.; Králová, Tereza; Bryjová, Anna; Albrecht, Tomáš; Bryja, Josef; Vinkler, M.

2014-01-01

Roč. 45, č. 1 (2014), s. 151-155 ISSN 0145-305X R&D Projects: GA ČR GAP505/10/1871 Institutional support: RVO:68081766 Keywords : Birds * Expression * Innate immunity * Toll-like receptor 5 * Pseudogene * Flagellin Subject RIV: EG - Zoology Impact factor: 2.815, year: 2014

DMPD: Critical role of toll-like receptors and nucleotide oligomerisation domain inthe regulation of health and disease. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available and nucleotide oligomerisation domain inthe regulation of health and disease. Pu...bmedID 17535871 Title Critical role of toll-like receptors and nucleotide oligomerisation domain inthe regulation of health...17535871 Critical role of toll-like receptors and nucleotide oligomerisation domain inthe regulation of heal...th and disease. Mitchell JA, Paul-Clark MJ, Clarke GW, McMaster SK, Cartwright N. J

Mortality and kidnapping estimates for the Yazidi population in the area of Mount Sinjar, Iraq, in August 2014: A retrospective household survey.

Science.gov (United States)

Cetorelli, Valeria; Sasson, Isaac; Shabila, Nazar; Burnham, Gilbert

2017-05-01

In August 2014, the so-called Islamic State of Iraq and Syria (ISIS) attacked the Yazidi religious minority living in the area of Mount Sinjar in Nineveh governorate, Iraq. We conducted a retrospective household survey to estimate the number and demographic profile of Yazidis killed and kidnapped. The survey covered the displaced Yazidi population from Sinjar residing in camps in the Kurdistan Region of Iraq. Fieldwork took place between 4 November and 25 December, 2015. A systematic random sample of 1,300 in-camp households were interviewed about the current household composition and any killings and kidnappings of household members by ISIS. Of the 1,300 interviewed households, 988 were Yazidi from Sinjar. Yazidi households contained 6,572 living residents at the time of the survey; 43 killings and 83 kidnappings of household members were reported. We calculated the probability of being killed and kidnapped by dividing the number of reported killings and kidnappings by the number of sampled Yazidis at risk, adjusting for sampling design. To obtain the overall toll of killings and kidnappings, those probabilities were multiplied by the total Yazidi population living in Sinjar at the time of the ISIS attack, estimated at roughly 400,000 by the United Nations and Kurdish officials. The demographic profile of those killed and kidnapped was examined, distinguishing between children and adults and females and males. We estimated that 2.5% of the Yazidi population was either killed or kidnapped over the course of a few days in August 2014, amounting to 9,900 (95% CI 7,000-13,900) people in total. An estimated 3,100 (95% CI 2,100-4,400) Yazidis were killed, with nearly half of them executed-either shot, beheaded, or burned alive-while the rest died on Mount Sinjar from starvation, dehydration, or injuries during the ISIS siege. The estimated number kidnapped is 6,800 (95% CI 4,200-10,800). Escapees recounted the abuses they had suffered, including forced religious

Mortality and kidnapping estimates for the Yazidi population in the area of Mount Sinjar, Iraq, in August 2014: A retrospective household survey.

Directory of Open Access Journals (Sweden)

Valeria Cetorelli

2017-05-01

Full Text Available In August 2014, the so-called Islamic State of Iraq and Syria (ISIS attacked the Yazidi religious minority living in the area of Mount Sinjar in Nineveh governorate, Iraq. We conducted a retrospective household survey to estimate the number and demographic profile of Yazidis killed and kidnapped.The survey covered the displaced Yazidi population from Sinjar residing in camps in the Kurdistan Region of Iraq. Fieldwork took place between 4 November and 25 December, 2015. A systematic random sample of 1,300 in-camp households were interviewed about the current household composition and any killings and kidnappings of household members by ISIS. Of the 1,300 interviewed households, 988 were Yazidi from Sinjar. Yazidi households contained 6,572 living residents at the time of the survey; 43 killings and 83 kidnappings of household members were reported. We calculated the probability of being killed and kidnapped by dividing the number of reported killings and kidnappings by the number of sampled Yazidis at risk, adjusting for sampling design. To obtain the overall toll of killings and kidnappings, those probabilities were multiplied by the total Yazidi population living in Sinjar at the time of the ISIS attack, estimated at roughly 400,000 by the United Nations and Kurdish officials. The demographic profile of those killed and kidnapped was examined, distinguishing between children and adults and females and males. We estimated that 2.5% of the Yazidi population was either killed or kidnapped over the course of a few days in August 2014, amounting to 9,900 (95% CI 7,000-13,900 people in total. An estimated 3,100 (95% CI 2,100-4,400 Yazidis were killed, with nearly half of them executed-either shot, beheaded, or burned alive-while the rest died on Mount Sinjar from starvation, dehydration, or injuries during the ISIS siege. The estimated number kidnapped is 6,800 (95% CI 4,200-10,800. Escapees recounted the abuses they had suffered, including forced

Hall Current Plasma Source Having a Center-Mounted or a Surface-Mounted Cathode

Science.gov (United States)

Martinez, Rafael A. (Inventor); Williams, John D. (Inventor); Moritz, Jr., Joel A. (Inventor); Farnell, Casey C. (Inventor)

2018-01-01

A miniature Hall current plasma source apparatus having magnetic shielding of the walls from ionized plasma, an integrated discharge channel and gas distributor, an instant-start hollow cathode mounted to the plasma source, and an externally mounted keeper, is described. The apparatus offers advantages over other Hall current plasma sources having similar power levels, including: lower mass, longer lifetime, lower part count including fewer power supplies, and the ability to be continuously adjustable to lower average power levels using pulsed operation and adjustment of the pulse duty cycle. The Hall current plasma source can provide propulsion for small spacecraft that either do not have sufficient power to accommodate a propulsion system or do not have available volume to incorporate the larger propulsion systems currently available. The present low-power Hall current plasma source can be used to provide energetic ions to assist the deposition of thin films in plasma processing applications.

Galvanic coupling effects for module-mounting elements of ground-mounted photovoltaic power station

Directory of Open Access Journals (Sweden)

Pierozynski Boguslaw

2017-12-01

Full Text Available This communication reports on the concerns associated with possible generation of galvanic coupling effects for construction materials that are used to manufacture mounting assemblies for ground-mounted photovoltaic (PV power stations. For this purpose, six macro-corrosion galvanic cells were assembled, including: hot-dip Zn/Magnelis®-coated steel/Al and stainless steel (SS/Al cells. Corrosion experiments involved continuous, ca. three-month exposure of these couplings in 3 wt.% NaCl solution, conducted at room temperature for a stable pH value of around 8. All corrosion cells were subjected to regular assessment of galvanic current-density and potential parameters, where special consideration was given to compare the corrosion behaviour of Zn-coated steel samples with that of Magnelis®-coated electrodes. Characterization of surface condition and elemental composition for examined materials was carried-out by means of SEM and EDX spectroscopy techniques.

The alpine flora of Mount Wilhelm (New Guinea)

NARCIS (Netherlands)

Hoogland, R.D.

1958-01-01

The flora of the higher mountains of New Guinea has been the object of several extensive collecting trips in the past forty years. Until quite recently, however, a serious gap in our knowledge was the very scanty information available from the area between Mount Wilhelmina in the West and Mount

Optimization of Classical Hydraulic Engine Mounts Based on RMS Method

Directory of Open Access Journals (Sweden)

J. Christopherson

2005-01-01

Full Text Available Based on RMS averaging of the frequency response functions of the absolute acceleration and relative displacement transmissibility, optimal parameters describing the hydraulic engine mount are determined to explain the internal mount geometry. More specifically, it is shown that a line of minima exists to define a relationship between the absolute acceleration and relative displacement transmissibility of a sprung mass using a hydraulic mount as a means of suspension. This line of minima is used to determine several optimal systems developed on the basis of different clearance requirements, hence different relative displacement requirements, and compare them by means of their respective acceleration and displacement transmissibility functions. In addition, the transient response of the mount to a step input is also investigated to show the effects of the optimization upon the time domain response of the hydraulic mount.

Mirror boxes and mirror mounts for photophysics beamline

International Nuclear Information System (INIS)

Raja Rao, P.M.; Raja Sekhar, B.N.; Das, N.C.; Khan, H.A.; Bhattacharya, S.S.; Roy, A.P.

1996-01-01

Photophysics beamline makes use of one metre Seya-Namioka monochromator and two toroidal mirrors in its fore optics. The first toroidal mirror (pre mirror) focuses light originating from the tangent point of the storage ring onto the entrance slit of the monochromator and second toroidal mirror (post mirror) collects light from the exit slit of the monochromator and focuses light onto the sample placed at a distance of about one metre away from the 2nd mirror. To steer light through monochromator and to focus it on the sample of 1mm x 1mm size require precision rotational and translational motion of the mirrors and this has been achieved with the help of precision mirror mounts. Since Indus-1 operates at pressures less than 10 -9 m.bar, the mirror mounts should be manipulated under similar ultra high vacuum conditions. Considering these requirements, two mirror boxes and two mirror mounts have been designed and fabricated. The coarse movements to the mirrors are imparted from outside the mirror chamber with the help of x-y tables and precision movements to the mirrors are achieved with the help of mirror mounts. The UHV compatibility and performance of the mirror mounts connected to mirror boxes under ultra high vacuum condition is evaluated. The details of the design, fabrication and performance evaluation are discussed in this report. 5 refs., 9 figs., 1 tab

Ball mounting fixture for a roundness gage

Science.gov (United States)

Gauler, Allen L.; Pasieka, Donald F.

1983-01-01

A ball mounting fixture for a roundness gage is disclosed. The fixture includes a pair of chuck assemblies oriented substantially transversely with respect to one another and mounted on a common base. Each chuck assembly preferably includes a rotary stage and a wobble plate affixed thereto. A ball chuck affixed to each wobble plate is operable to selectively support a ball to be measured for roundness, with the wobble plate permitting the ball chuck to be tilted to center the ball on the axis of rotation of the rotary stage. In a preferred embodiment, each chuck assembly includes a vacuum chuck operable to selectively support the ball to be measured for roundness. The mounting fixture enables a series of roundness measurements to be taken with a conventional rotating gagehead roundness instrument, which measurements can be utilized to determine the sphericity of the ball.

Tension pneumocephalus: Mount Fuji sign

Directory of Open Access Journals (Sweden)

Pulastya Sanyal

2015-01-01

Full Text Available A 13-year-old male was operated for a space occupying lesion in the brain. A noncontrast computed tomography scan done in the late postoperative period showed massive subdural air collection causing compression of bilateral frontal lobes with widening of interhemispheric fissure and the frontal lobes acquiring a peak like configuration - causing tension pneumocephalus-"Mount Fuji sign." Tension pneumocephalus occurs when air enters the extradural or intradural spaces in sufficient volume to exert a mass or pressure effect on the brain, leading to brain herniation. Tension pneumocephalus is a surgical emergency, which needs immediate intervention in the form of decompression of the cranial cavity by a burr hole or needle aspiration. The Mount Fuji sign differentiates tension pneumocephalus from pneumocephalus.

Taking Charge: Walter Sydney Adams and the Mount Wilson Observatory

Science.gov (United States)

Brashear, R.

2004-12-01

The growing preeminence of American observational astronomy in the first half of the 20th century is a well-known story and much credit is given to George Ellery Hale and his skill as an observatory-building entrepreneur. But a key figure who has yet to be discussed in great detail is Walter Sydney Adams (1876-1956), Hale's Assistant Director at Mount Wilson Observatory. Due to Hale's illnesses, Adams was Acting Director for much of Hale's tenure, and he became the second Director of Mount Wilson from 1923 to 1946. Behind his New England reserve Adams was instrumental in the growth of Mount Wilson and thus American astronomy in general. Adams was hand-picked by Hale to take charge of stellar spectroscopy work at Yerkes and Mount Wilson and the younger astronomer showed tremendous loyalty to Hale and Hale's vision throughout his career. As Adams assumed the leadership role at Mount Wilson he concentrated on making the observatory a place where researchers worked with great freedom but maintain a high level of cooperation. This paper will concentrate on Adams's early years and look at his growing relationship with Hale and how he came to be the central figure in the early history of Mount Wilson as both a solar and stellar observatory. His education, his years at Dartmouth and Yerkes (including his unfortunate encounter with epsilon Leonis), and his formative years on Mount Wilson are all important in learning how he shaped the direction of Mount Wilson and the development of American astronomy in the first half of the 20th century. This latter history cannot be complete until we bring Adams into better focus.

Colorectal irradiation induced immune response: 'toll like receptors' therapeutic manipulation

International Nuclear Information System (INIS)

Lacave-Lapalun, Jean-Victor

2013-01-01

Exposure of the abdomino-pelvic sphere to ionizing radiation is associated with a high incidence of complications. Radiation therapy may cause short and / or long-term harmful effects. In the most severe cases and in the absence of heavy treatments, the appearance of ulcers may induce the death of patients. Clinical trials are being conducted with Mesenchymal Stem Cells (MSC) to cure theses complications. Others studies indicate that the injection of bacterial motifs limits the radiotoxicity in the intestine. They stimulate receptors (Toll-Like- Receptors (TLR)) located on the surface of epithelial and intestinal immune cells. The first aim of this doctoral work is to characterize the effects of TLR stimulation on immunity and tissue repair using a model of localized colorectal irradiation at 20 Gy (acute effects of radiotherapy) on a rat. The thesis then aims to potentiate the effects of the MSC treatment when adding TLR ligands upon localized colorectal irradiation at 27 Gy (accidental complications). This work, using a 20 Gy exposure, show that TLR stimulation improves homeostasis (normalization of T cells, induction of regulatory T cells (Treg) and macrophages 'anti-inflammatory' M2). On the 27 Gy colorectal model, the injection of TLR ligand before CSM transplant improves the immune climate by reducing pro-inflammatory cytokines and inducting Treg and M2 cells. These modulations could contribute to improving the implantation and effectiveness of CSM. The observations have all shown that the stimulation of immunity is an approach to minimize radiation-induced lesions. (author) [fr

Digital Data for Volcano Hazards in the Mount Jefferson Region, Oregon

Science.gov (United States)

Schilling, S.P.; Doelger, S.; Walder, J.S.; Gardner, C.A.; Conrey, R.M.; Fisher, B.J.

2008-01-01

Mount Jefferson has erupted repeatedly for hundreds of thousands of years, with its last eruptive episode during the last major glaciation which culminated about 15,000 years ago. Geologic evidence shows that Mount Jefferson is capable of large explosive eruptions. The largest such eruption occurred between 35,000 and 100,000 years ago. If Mount Jefferson erupts again, areas close to the eruptive vent will be severely affected, and even areas tens of kilometers (tens of miles) downstream along river valleys or hundreds of kilometers (hundreds of miles) downwind may be at risk. Numerous small volcanoes occupy the area between Mount Jefferson and Mount Hood to the north, and between Mount Jefferson and the Three Sisters region to the south. These small volcanoes tend not to pose the far-reaching hazards associated with Mount Jefferson, but are nonetheless locally important. A concern at Mount Jefferson, but not at the smaller volcanoes, is the possibility that small-to-moderate sized landslides could occur even during periods of no volcanic activity. Such landslides may transform as they move into lahars (watery flows of rock, mud, and debris) that can inundate areas far downstream. The geographic information system (GIS) volcano hazard data layer used to produce the Mount Jefferson volcano hazard map in USGS Open-File Report 99-24 (Walder and others, 1999) is included in this data set. Both proximal and distal hazard zones were delineated by scientists at the Cascades Volcano Observatory and depict various volcano hazard areas around the mountain.

Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome

DEFF Research Database (Denmark)

Coenen, Marieke J H; Enevold, Christian; Barrera, Pilar

2010-01-01

Several studies point to a role of Toll-like receptors (TLRs) in the development of rheumatoid arthritis (RA). We investigated if genetic variants in TLR genes are associated with RA and response to tumour necrosis factor blocking (anti-TNF) medication.......Several studies point to a role of Toll-like receptors (TLRs) in the development of rheumatoid arthritis (RA). We investigated if genetic variants in TLR genes are associated with RA and response to tumour necrosis factor blocking (anti-TNF) medication....

A magneto-rheological fluid mount featuring squeeze mode: analysis and testing

International Nuclear Information System (INIS)

Chen, Peng; Bai, Xian-Xu; Qian, Li-Jun; Choi, Seung-Bok

2016-01-01

This paper presents a mathematical model for a new semi-active vehicle engine mount utilizing magneto-rheological (MR) fluids in squeeze mode (MR mount in short) and validates the model by comparing analysis results with experimental tests. The proposed MR mount is mainly comprised of a frame for installation, a main rubber, a squeeze plate and a bobbin for coil winding. When the magnetic fields on, MR effect occurs in the upper gap between the squeeze plate and the bobbin, and the dynamic stiffness can be controlled by tuning the applied currents. Employing Bingham model and flow properties between parallel plates of MR fluids, a mathematical model for the squeeze type of MR mount is formulated with consideration of the fluid inertia, MR effect and hysteresis property. The field-dependent dynamic stiffness of the MR mount is then analyzed using the established mathematical model. Subsequently, in order to validate the mathematical model, an appropriate size of MR mount is fabricated and tested. The field-dependent force and dynamic stiffness of the proposed MR mount are evaluated and compared between the model and experimental tests in both time and frequency domains to verify the model efficiency. In addition, it is shown that both the damping property and the stiffness property of the proposed MR mount can be simultaneously controlled. (paper)

Solar rotation measurements at Mount Wilson. Pt. 2

International Nuclear Information System (INIS)

Labonte, B.J.; Howard, R.; Carnegie Institution of Washington, Pasadena

1981-01-01

Possible sources of systematic error in solar Doppler rotational velocities are examined. Scattered light is shown to affect the Mount Wilson solar rotation results, but this effect is not enough to bring the spectroscopic results in coincidence with the sunspot rotation. Interference fringes at the spectrograph focus at Mount Wilson have in two intervals affected the rotation results. It has been possible to correlate this error with temperature and thus correct for it. A misalignment between the entrance and exit slits is a possible source of error, but for the Mount Wilson slit configuration the amplitude of this effect is negligibly small. Rapid scanning of the solar image also produces no measurable effect. (orig.)

Rapid mounting of adult Drosophila structures in Hoyer's medium.

Science.gov (United States)

Stern, David L; Sucena, Elio

2012-01-01

The Drosophila cuticle carries a rich array of morphological details. Thus, cuticle examination has had a central role in the history of genetics. This protocol describes a procedure for mounting adult cuticles in Hoyer's medium, a useful mountant for both larval and adult cuticles. The medium digests soft tissues rapidly, leaving the cuticle cleared for observation. In addition, samples can be transferred directly from water to Hoyer's medium. However, specimens mounted in Hoyer's medium degrade over time. For example, the fine denticles on the larval dorsum are best observed soon after mounting; they begin to fade after 1 week, and can disappear completely after several months. More robust features, such as the ventral denticle belts, will persist for a longer period of time. Because adults cannot profitably be mounted whole in Hoyer's medium, some dissection is necessary.

Mounting system for optical frequency reference cavities

Science.gov (United States)

Notcutt, Mark (Inventor); Hall, John L. (Inventor); Ma, Long-Sheng (Inventor)

2008-01-01

A technique for reducing the vibration sensitivity of laser-stabilizing optical reference cavities is based upon an improved design and mounting method for the cavity, wherein the cavity is mounted vertically. It is suspended at one plane, around the spacer cylinder, equidistant from the mirror ends of the cavity. The suspension element is a collar of an extremely low thermal expansion coefficient material, which surrounds the spacer cylinder and contacts it uniformly. Once the collar has been properly located, it is cemented in place so that the spacer cylinder is uniformly supported and does not have to be squeezed at all. The collar also includes a number of cavities partially bored into its lower flat surface, around the axial bore. These cavities are support points, into which mounting base pins will be inserted. Hence the collar is supported at a minimum of three points.

Exploring Virtual Worlds With Head-Mounted Displays

Science.gov (United States)

Chung, James C.; Harris, Mark R.; Brooks, Frederick P.; Fuchs, Henry; Kelley, Michael T.; Hughes, John W.; Ouh-Young, Ming; Cheung, Clement; Holloway, Richard L.; Pique, Michael

1989-09-01

For nearly a decade the University of North Carolina at Chapel Hill has been conducting research in the use of simple head-mounted displays in "real-world" applications. Such units provide the user with non-holographic true three-dimensional information, since the kinetic depth effect, stereoscopy, and other visual cues combine to immerse the user in a "virtual world" which behaves like the real world in some respects. UNC's head-mounted display was built inexpensively from commercially available off-the-shelf components. Tracking of the the user's head position and orientation is performed by a Polhemus Navigation Sciences' 3SPACE* tracker. The host computer uses the tracking information to generate updated images corresponding to the user's new left eye and right eye views. The images are broadcast to two liquid crystal television screens (220x320 pixels) mounted on a horizontal shelf at the user's forehead. The user views these color screens through half-silvered mirrors, enabling the computer-generated image to be superimposed upon the user's real physical environment. The head-mounted display has been incorporated into existing molecular modeling and architectural applications being developed at UNC. In molecular structure studies, chemists are presented with a room-sized molecule with which they can interact in a manner more intuitive than that provided by conventional two-dimensional displays and dial boxes. Walking around and through the large molecule may provide quicker understanding of its structure, and such problems as drug-enzyme docking may be approached with greater insight. In architecture, the head-mounted display enables clients to better appreciate three-dimensional designs, which may be misinterpreted in their conventional two-dimensional form by untrained eyes. The addition of a treadmill to the system provides additional kinesthetic input into the understanding of building size and scale.

Toll-Like Receptors: Role in Dermatological Disease

Directory of Open Access Journals (Sweden)

Aswin Hari

2010-01-01

Full Text Available Toll-like receptors (TLRs are a class of conserved receptors that recognize pathogen-associated molecular patterns (PAMPs present in microbes. In humans, at least ten TLRs have been identified, and their recognition targets range from bacterial endotoxins to lipopeptides, DNA, dsRNA, ssRNA, fungal products, and several host factors. Of dermatological interest, these receptors are expressed on several skin cells including keratinocytes, melanocytes, and Langerhans cells. TLRs are essential in identifying microbial products and are known to link the innate and adaptive immune systems. Over the years, there have been significant advances in our understanding of TLRs in skin inflammation, cutaneous malignancies, and defence mechanisms. In this paper, we will describe the association between TLRs and various skin pathologies and discuss proposed TLR therapeutics.

Mount Oku, Cameroon Volcanic Line

African Journals Online (AJOL)

and continental sectors especially for trace elements in basalts. ... continental sector of the trend is a complex .... values higher than those of HIMU but is within ...... (Mount Cameroon, Central Africa): petrogenetic implications. Miner. Petrol.,.

Micro-inverter solar panel mounting

Science.gov (United States)

Morris, John; Gilchrist, Phillip Charles

2016-02-02

Processes, systems, devices, and articles of manufacture are provided. Each may include adapting micro-inverters initially configured for frame-mounting to mounting on a frameless solar panel. This securement may include using an adaptive clamp or several adaptive clamps secured to a micro-inverter or its components, and using compressive forces applied directly to the solar panel to secure the adaptive clamp and the components to the solar panel. The clamps can also include compressive spacers and safeties for managing the compressive forces exerted on the solar panels. Friction zones may also be used for managing slipping between the clamp and the solar panel during or after installation. Adjustments to the clamps may be carried out through various means and by changing the physical size of the clamps themselves.

Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish.

NARCIS (Netherlands)

Meijer, A.H.; Krens, SF Gabby; Rodriguez, IA Medina; He, S; Bitter, W.; Snaar-Jagalska, B Ewa; Spaink, H.P.

2004-01-01

The zebrafish genomic sequence database was analysed for the presence of genes encoding members of the Toll-like receptors (TLR) and interleukin receptors (IL-R) and associated adaptor proteins containing a TIR domain. The resulting predictions show the presence of one or more counterparts for the

Role of toll like receptors in bacterial and viral diseases – A systemic ...

African Journals Online (AJOL)

Background: Toll like receptors are key-receptors of the innate immune system, but their role against bacterial and viral infections are yet to be understood. Aim: The present study is aimed to investigate the diversity and frequency distribution of 10 TLR genes among typhoid fever and HIV+ patients. In this study, 44 samples ...

Geology of the Ugashik-Mount Peulik Volcanic Center, Alaska

Science.gov (United States)

Miller, Thomas P.

2004-01-01

The Ugashik-Mount Peulik volcanic center, 550 km southwest of Anchorage on the Alaska Peninsula, consists of the late Quaternary 5-km-wide Ugashik caldera and the stratovolcano Mount Peulik built on the north flank of Ugashik. The center has been the site of explosive volcanism including a caldera-forming eruption and post-caldera dome-destructive activity. Mount Peulik has been formed entirely in Holocene time and erupted in 1814 and 1845. A large lava dome occupies the summit crater, which is breached to the west. A smaller dome is perched high on the southeast flank of the cone. Pyroclastic-flow deposits form aprons below both domes. One or more sector-collapse events occurred early in the formation of Mount Peulik volcano resulting in a large area of debris-avalanche deposits on the volcano's northwest flank. The Ugashik-Mount Peulik center is a calcalkaline suite of basalt, andesite, dacite, and rhyolite, ranging in SiO2 content from 51 to 72 percent. The Ugashik-Mount Peulik magmas appear to be co-genetic in a broad sense and their compositional variation has probably resulted from a combination of fractional crystallization and magma-mixing. The most likely scenario for a future eruption is that one or more of the summit domes on Mount Peulik are destroyed as new magma rises to the surface. Debris avalanches and pyroclastic flows may then move down the west and, less likely, east flanks of the volcano for distances of 10 km or more. A new lava dome or series of domes would be expected to form either during or within some few years after the explosive disruption of the previous dome. This cycle of dome disruption, pyroclastic flow generation, and new dome formation could be repeated several times in a single eruption. The volcano poses little direct threat to human population as the area is sparsely populated. The most serious hazard is the effect of airborne volcanic ash on aircraft since Mount Peulik sits astride heavily traveled air routes connecting the U

Mannose-Binding Lectin and Toll-Like Receptor Polymorphisms and Chagas Disease in Chile

Science.gov (United States)

Zulantay, Inés; Danquah, Ina; Hamann, Lutz; Schumann, Ralf R.; Apt, Werner; Mockenhaupt, Frank P.

2012-01-01

Mannose-binding lectin (MBL) and Toll-like receptor (TLR) polymorphisms may influence susceptibility and manifestation of Trypanosoma cruzi infection. In northern Chile, we examined 61 asymptomatic patients with chronic Chagas disease (CD), 64 patients with chronic Chagas cardiomyopathy (CCC), and 45 healthy individuals. Low-producer MBL2*B genotypes were more common in CD patients (48%) than healthy individuals (31%; adjusted odds ratio = 2.3, 95% confidence interval = 1.01–5.4, P = 0.047) but did not differ with manifestation. In contrast, the heterozygous Toll-like receptor 4 (TLR4)-deficiency genotype D299G/T399I occurred more frequently in asymptomatic (14.8%) than CCC patients (3.1%; P = 0.02). TLR1-I602S, TLR2-R753Q, TLR6-S249P, and MAL/TIRAP-S180L did not associate with CD or CCC. These findings support the complement system to be involved in defense against Trypanosoma cruzi infection and indicate that curbed TLR4 activation might be beneficial in preventing CCC. PMID:22302853

Alternative mounting media for preservation of some protozoa.

Science.gov (United States)

Criado-Fornelio, A; Heredero-Bermejo, I; Pérez-Serrano, J

2014-10-01

Protozoa resistant stages are disintegrated when mounted in toluene-based media. To overcome such problem, three toluene-free mountants were tested on preserve Acanthamoeba spp and gregarines. Two commercial glues based on cyanoacrylate or trimethoxysilane were suitable for preserving both cysts and trophozoites. Hoyer's medium showed good results for mounting gregarine oocysts. Copyright © 2014 Elsevier B.V. All rights reserved.

Hole-thru-laminate mounting supports for photovoltaic modules

Science.gov (United States)

Wexler, Jason; Botkin, Jonathan; Culligan, Matthew; Detrick, Adam

2015-02-17

A mounting support for a photovoltaic module is described. The mounting support includes a pedestal having a surface adaptable to receive a flat side of a photovoltaic module laminate. A hole is disposed in the pedestal, the hole adaptable to receive a bolt or a pin used to couple the pedestal to the flat side of the photovoltaic module laminate.

Three-dimensional repositioning accuracy of semiadjustable articulator cast mounting systems.

Science.gov (United States)

Tan, Ming Yi; Ung, Justina Youlin; Low, Ada Hui Yin; Tan, En En; Tan, Keson Beng Choon

2014-10-01

In spite of its importance in prosthesis precision and quality, the 3-dimensional repositioning accuracy of cast mounting systems has not been reported in detail. The purpose of this study was to quantify the 3-dimensional repositioning accuracy of 6 selected cast mounting systems. Five magnetic mounting systems were compared with a conventional screw-on system. Six systems on 3 semiadjustable articulators were evaluated: Denar Mark II with conventional screw-on mounting plates (DENSCR) and magnetic mounting system with converter plates (DENCON); Denar Mark 330 with in-built magnetic mounting system (DENMAG) and disposable mounting plates; and Artex CP with blue (ARTBLU), white (ARTWHI), and black (ARTBLA) magnetic mounting plates. Test casts with 3 high-precision ceramic ball bearings at the mandibular central incisor (Point I) and the right and left second molar (Point R; Point L) positions were mounted on 5 mounting plates (n=5) for all 6 systems. Each cast was repositioned 10 times by 4 operators in random order. Nine linear (Ix, Iy, Iz; Rx, Ry, Rz; Lx, Ly, Lz) and 3 angular (anteroposterior, mediolateral, twisting) displacements were measured with a coordinate measuring machine. The mean standard deviations of the linear and angular displacements defined repositioning accuracy. Anteroposterior linear repositioning accuracy ranged from 23.8 ±3.7 μm (DENCON) to 4.9 ±3.2 μm (DENSCR). Mediolateral linear repositioning accuracy ranged from 46.0 ±8.0 μm (DENCON) to 3.7 ±1.5 μm (ARTBLU), and vertical linear repositioning accuracy ranged from 7.2 ±9.6 μm (DENMAG) to 1.5 ±0.9 μm (ARTBLU). Anteroposterior angular repositioning accuracy ranged from 0.0084 ±0.0080 degrees (DENCON) to 0.0020 ±0.0006 degrees (ARTBLU), and mediolateral angular repositioning accuracy ranged from 0.0120 ±0.0111 degrees (ARTWHI) to 0.0027 ±0.0008 degrees (ARTBLU). Twisting angular repositioning accuracy ranged from 0.0419 ±0.0176 degrees (DENCON) to 0.0042 ±0.0038 degrees

Sensor mount assemblies and sensor assemblies

Science.gov (United States)

Miller, David H [Redondo Beach, CA

2012-04-10

Sensor mount assemblies and sensor assemblies are provided. In an embodiment, by way of example only, a sensor mount assembly includes a busbar, a main body, a backing surface, and a first finger. The busbar has a first end and a second end. The main body is overmolded onto the busbar. The backing surface extends radially outwardly relative to the main body. The first finger extends axially from the backing surface, and the first finger has a first end, a second end, and a tooth. The first end of the first finger is disposed on the backing surface, and the tooth is formed on the second end of the first finger.

Toll-like receptors and cancer: MYD88 mutation and inflammation

Directory of Open Access Journals (Sweden)

James Q Wang

2014-07-01

Full Text Available Pattern recognition receptors (PRRs expressed on immune cells are crucial for the early detection of invading pathogens, in initiating early innate immune response and in orchestrating the adaptive immune response. PRRs are activated by specific pathogen-associated molecular patterns (PAMPs that are present in pathogenic microbes or nucleic acids of viruses or bacteria. However, inappropriate activation of these PRRs, such as the Toll-like receptors (TLRs, due to genetic lesions or chronic inflammation has been demonstrated to be a major cause of many haematological malignancies. Gain-of-function mutations in the TLR adaptor protein MYD88 found in 39% of the activated B cell type of diffuse large B cell lymphomas (ABC-DLBCL and almost 100% of Waldenström’s macroglobulinemia (WM further highlight the involvement of TLRs in these malignancies. MYD88 mutations result in the chronic activation of TLR signalling pathways, thus the constitutive activation of the transcription factor NFκB to promote cell survival and proliferation. These recent insights into TLR pathway driven malignancies warrant the need for a better understanding of TLRs in cancers and the development of novel anti-cancer therapies targeting TLRs. This review focuses on Toll-like receptors function and signalling in normal or inflammatory conditions, and how mutations can also hijack the TLR signalling pathways to give rise to cancer. Lastly, we discuss how potential therapeutic agents could be used to restore normal responses to TLRs and have long lasting anti-tumour effects.

Toll-like receptor 4 plays a protective role in pulmonary tuberculosis in mice

NARCIS (Netherlands)

Branger, Judith; Leemans, Jaklien C.; Florquin, Sandrine; Weijer, Sebastiaan; Speelman, Peter; van der Poll, Tom

2004-01-01

Toll-like receptors (TLR) play an essential role in the innate recognition of microorganisms by the host. To determine the role of TLR4 in host defense against lung tuberculosis, TLR4 mutant (C3H/HeJ) and wild-type (C3H/HeN) mice were intranasally infected with live Mycobacterium tuberculosis. TLR4

The January 2006 Volcanic-Tectonic Earthquake Swarm at Mount Martin, Alaska

Science.gov (United States)

Dixon, James P.; Power, John A.

2009-01-01

On January 8, 2006, a swarm of volcanic-tectonic earthquakes began beneath Mount Martin at the southern end of the Katmai volcanic cluster. This was the first recorded swarm at Mount Martin since continuous seismic monitoring began in 1996. The number of located earthquakes increased during the next four days, reaching a peak on January 11. For the next two days, the seismic activity decreased, and on January 14, the number of events increased to twice the previous day's total. Following this increase in activity, seismicity declined, returning to background levels by the end of the month. The Alaska Volcano Observatory located 860 earthquakes near Mount Martin during January 2006. No additional signs of volcanic unrest were noted in association with this earthquake swarm. The earthquakes in the Mount Martin swarm, relocated using the double difference technique, formed an elongated cluster dipping to the southwest. Focal mechanisms beneath Mount Martin show a mix of normal, thrust, and strike-slip solutions, with normal focal mechanisms dominating. For earthquakes more than 1 km from Mount Martin, all focal mechanisms showed normal faulting. The calculated b-value for the Mount Martin swarm is 0.98 and showed no significant change before, during, or after the swarm. The triggering mechanism for the Mount Martin swarm is unknown. The time-history of earthquake occurrence is indicative of a volcanic cause; however, there were no low-frequency events or observations, such as increased steaming associated with the swarm. During the swarm, there was no change in the b-value, and the distribution and type of focal mechanisms were similar to those in the period before the anomalous activity. The short duration of the swarm, the similarity in observed focal mechanisms, and the lack of additional signs of unrest suggest this swarm did not result from a large influx of magma within the shallow crust beneath Mount Martin.

Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens

Science.gov (United States)

Martínez, Isidoro; Oliveros, Juan C.; Cuesta, Isabel; de la Barrera, Jorge; Ausina, Vicente; Casals, Cristina; de Lorenzo, Alba; García, Ernesto; García-Fojeda, Belén; Garmendia, Junkal; González-Nicolau, Mar; Lacoma, Alicia; Menéndez, Margarita; Moranta, David; Nieto, Amelia; Ortín, Juan; Pérez-González, Alicia; Prat, Cristina; Ramos-Sevillano, Elisa; Regueiro, Verónica; Rodriguez-Frandsen, Ariel; Solís, Dolores; Yuste, José; Bengoechea, José A.; Melero, José A.

2017-01-01

Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here. PMID:28298903

Low-stress mounting configuration design for large aperture laser transport mirror

Science.gov (United States)

Zhang, Zheng; Quan, Xusong; Yao, Chao; Wang, Hui

2016-10-01

TM1-6S1 large aperture laser transport mirror is a crucial optical unit of high power solid-state laser in the Inertial Confinement Fusion (ICF) facility. This article focuses on the low-stress and precise mounting method of large-aperture mirror. Based on the engineering practice of SG-III, the state-of-the-art and key problems of current mounting configuration are clarified firstly. Subsequently, a brand new low-stress mounting configuration with flexure supports is proposed. Opto-mechanical model of the mirror under mounting force is built up with elastic mechanics theory. Further, numerical methods and field tests are employed to verify the favorable load uniform capacity and load adjust capacity of flexure supports. With FEM, the relation between the mounting force from new configuration and the mirror surface distortion (wavefront error) is clarified. The novel mounting method of large aperture optics could be not only used on this laser transport mirror, but also on the other transmission optics and large crystals in ICF facilities.

Head-Mounted Display Technology for Low Vision Rehabilitation and Vision Enhancement

Science.gov (United States)

Ehrlich, Joshua R.; Ojeda, Lauro V.; Wicker, Donna; Day, Sherry; Howson, Ashley; Lakshminarayanan, Vasudevan; Moroi, Sayoko E.

2017-01-01

Purpose To describe the various types of head-mounted display technology, their optical and human factors considerations, and their potential for use in low vision rehabilitation and vision enhancement. Design Expert perspective. Methods An overview of head-mounted display technology by an interdisciplinary team of experts drawing on key literature in the field. Results Head-mounted display technologies can be classified based on their display type and optical design. See-through displays such as retinal projection devices have the greatest potential for use as low vision aids. Devices vary by their relationship to the user’s eyes, field of view, illumination, resolution, color, stereopsis, effect on head motion and user interface. These optical and human factors considerations are important when selecting head-mounted displays for specific applications and patient groups. Conclusions Head-mounted display technologies may offer advantages over conventional low vision aids. Future research should compare head-mounted displays to commonly prescribed low vision aids in order to compare their effectiveness in addressing the impairments and rehabilitation goals of diverse patient populations. PMID:28048975

Robotic mounting of ATLAS barrel SCT modules

International Nuclear Information System (INIS)

Nickerson, R.B.; Viehhauser, G.; Wastie, R.; Terada, S.; Unno, Y.; Kohriki, T.; Ikegami, Y.; Hara, K.; Kobayashi, H.; Barbier, G.; Clark, A.G.; Perrin, E.; Carter, A.A.; Mistry, J.; Morris, J.

2006-01-01

The 2112 silicon detector modules of the barrel part of the ATLAS SemiConductor Tracker (SCT) have been mounted on their carbon fibre support structure. Module insertion, placement and fixing were performed by robotic assembly tooling. We report on our experience with this assembly method. Part of the mounting sequence involves a partial survey of elements of the support structure which is needed to align the modules properly during insertion. An analysis of these data is used to estimate the positional accuracy of the robots

Hypothalamic neuronal toll-like receptor 2 protects against age-induced obesity

OpenAIRE

Shechter, Ravid; London, Anat; Kuperman, Yael; Ronen, Ayal; Rolls, Asya; Chen, Alon; Schwartz, Michal

2013-01-01

Toll-like receptors (TLRs) are traditionally associated with immune-mediated host defense. Here, we ascribe a novel extra-immune, hypothalamic-associated function to TLR2, a TLR-family member known to recognize lipid components, in the protection against obesity. We found that TLR2-deficient mice exhibited mature-onset obesity and susceptibility to high-fat diet (HFD)-induced weight gain, via modulation of food intake. Age-related obesity was still evident in chimeric mice, carrying comparabl...

National Ingition Facility subsystem design requirements optical mounts SSDR 1.4.4

International Nuclear Information System (INIS)

Richardson, M.

1996-01-01

This SSDR establishes the performance, design, development and test requirements for NIF Beam Transport Optomechanical Subsystems. optomechanical Subsystems includes the mounts for the beam transport mirrors, LMl - LM8, the polarizer mount, and the spatial filter lens mounts

Some technical solutions on organization and technology of reactor room component mounting

International Nuclear Information System (INIS)

Romanovskij, V.I.

1982-01-01

Design of the production equipment for mounting sites of heat facilities of the Zaporozhe NPP is considered. Plan of the production equipment for mounting sites of heat facilities and flowsheet of mounting of supporting truss of the reactor are presented

Polymethylmethacrylate-based luminescent solar concentrators with bottom-mounted solar cells

International Nuclear Information System (INIS)

Zhang, Yi; Sun, Song; Kang, Rui; Zhang, Jun; Zhang, Ningning; Yan, Wenhao; Xie, Wei; Ding, Jianjun; Bao, Jun; Gao, Chen

2015-01-01

Graphical abstract: - Highlights: • Bottom-mounted luminescent solar concentrators on dye-doped plates were studied. • The mechanism of transport process was proposed. • The fabricated luminescent solar concentrator achieved a gain of 1.38. • Power conversion efficiency of 5.03% was obtained with cell area coverage of 27%. • The lowest cost per watt of $1.89 was optimized with cell area coverage of 18%. - Abstract: Luminescent solar concentrators offer an attractive approach to concentrate sunlight economically without tracking, but the narrow absorption band of luminescent materials hinders their further development. This paper describes bottom-mounted luminescent solar concentrators on dye-doped polymethylmethacrylate plates that absorb not only the waveguided light but also the transmitted sunlight and partial fluorescent light in the escape cone. A series of bottom-mounted luminescent solar concentrators with size of 78 mm × 78 mm × 7 mm were fabricated and their gain and power conversion efficiency were investigated. The transport process of the waveguided light and the relationship between the bottom-mounted cells were studied to optimize the performance of the device. The bottom-mounted luminescent solar concentrator with cell area coverage of 9% displayed a cell gain of 1.38, to our best knowledge, which is the highest value for dye-doped polymethylmethacrylate plate luminescent solar concentrators. Power conversion efficiency as high as 5.03% was obtained with cell area coverage of 27%. Furthermore, the bottom-mounted luminescent solar concentrator was found to have a lowest cost per watt of $1.89 with cell area coverage of 18%. These results suggested that the fabricated bottom-mounted luminescent solar concentrator may have a potential in low-cost building integrated photovoltaic application

Differential expression of toll-like receptors in patients with irritable bowel syndrome.

LENUS (Irish Health Repository)

Brint, Elizabeth K

2011-02-01

The pathogenesis of irritable bowel syndrome (IBS) is poorly understood. One contributory factor may be low-grade mucosal inflammation, perhaps initiated by the microbiota. Toll-like receptors (TLRs) are a family of pathogen-recognition receptors of the innate immune system. The aim of this study was to evaluate the potential involvement of TLRs in IBS to further understand the involvement of the innate immune system in this complex disorder.

Activation of toll-like receptors and dendritic cells by a broad range of bacterial molecules

NARCIS (Netherlands)

Boele, L.C.L.; Bajramovic, J.J.; Vries, A.M.M.B.C. de; Voskamp-Visser, I.A.I.; Kaman, W.E.; Kleij, D. van der

2009-01-01

Activation of pattern recognition receptors such as Toll-like receptors (TLRs) by pathogens leads to activation and maturation of dendritic cells (DC), which orchestrate the development of the adaptive immune response. To create an overview of the effects of a broad range of pathogenic bacteria,

The Role of Toll-Like Receptor 2 in Inflammation and Fibrosis during Progressive Renal Injury

NARCIS (Netherlands)

Leemans, Jaklien C.; Butter, Loes M.; Pulskens, Wilco P. C.; Teske, Gwendoline J. D.; Claessen, Nike; van der Poll, Tom; Florquin, Sandrine

2009-01-01

Tissue fibrosis and chronic inflammation are common causes of progressive organ damage, including progressive renal disease, leading to loss of physiological functions. Recently, it was shown that Toll-like receptor 2 (TLR2) is expressed in the kidney and activated by endogenous danger signals. The

A new mount with moving-magnet type electromagnetic actuator for naval shipboard equipment

Directory of Open Access Journals (Sweden)

Yun-Ho Shin

2015-01-01

Full Text Available This study is proposed a new hybrid mount having a moving-magnet type electromagnetic actuator to reduce the vibration transmitted from naval shipboard equipment to the structure of the ship 's hull. Optimal design specifications are determined through experimental analysis. The detailed design of the hybrid mount is determined through several design steps with electromagnetic numerical analysis using Maxwell Software(S/W. The hybrid mount that combines a rubber mount and an electromagnetic actuator has a fail-safe function for shock resistance. The mount is fabricated and tested using a universal testing machine to evaluate the design specifications. Finally, numerical simulation of the hybrid mount is performed to confirm control performance and applicability.

Toll-like receptors as targets for immune disorders.

LENUS (Irish Health Repository)

Keogh, Brian

2012-02-01

Since the identification of the first Toll-like receptor (TLR) in humans in 1997, understanding of the molecular basis for innate immunity has increased significantly. The TLR family and downstream signalling pathways have been extensively characterised, There is now significant evidence suggesting a role for TLRs in human inflammatory and immune diseases such as rheumatoid arthritis, diabetes, allergy\\/asthma and atherosclerosis. Various approaches have been taken to identify novel therapeutic agents targeting TLRs including biologics, small molecules and nucleic acid-based drugs. Several are now being evaluated in the clinic and showing promise against various diseases. This review paper outlines the recent advances in the understanding of TLR biology and highlights novel TLR agonists and antagonists in development for the treatment of immune diseases.

49 CFR 587.19 - Mounting.

Science.gov (United States)

2010-10-01

... Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) DEFORMABLE BARRIERS Offset Deformable Barrier § 587.19 Mounting. (a) The deformable face is rigidly attached to the edge of the fixed rigid barrier or to some rigid...

Preparation of samples for leaf architecture studies, a method for mounting cleared leaves.

Science.gov (United States)

Vasco, Alejandra; Thadeo, Marcela; Conover, Margaret; Daly, Douglas C

2014-09-01

Several recent waves of interest in leaf architecture have shown an expanding range of approaches and applications across a number of disciplines. Despite this increased interest, examination of existing archives of cleared and mounted leaves shows that current methods for mounting, in particular, yield unsatisfactory results and deterioration of samples over relatively short periods. Although techniques for clearing and staining leaves are numerous, published techniques for mounting leaves are scarce. • Here we present a complete protocol and recommendations for clearing, staining, and imaging leaves, and, most importantly, a method to permanently mount cleared leaves. • The mounting protocol is faster than other methods, inexpensive, and straightforward; moreover, it yields clear and permanent samples that can easily be imaged, scanned, and stored. Specimens mounted with this method preserve well, with leaves that were mounted more than 35 years ago showing no signs of bubbling or discoloration.

Active Figure Control Effects on Mounting Strategy for X-Ray Optics

Science.gov (United States)

Kolodziejczak, Jeffery J.; Atkins, Carolyn; Roche, Jacqueline M.; ODell, Stephen L.; Ramsey, Brian D.; Elsner, Ronald F.; Weisskopf, Martin C.; Gubarev, Mikhail V.

2014-01-01

As part of ongoing development efforts at MSFC, we have begun to investigate mounting strategies for highly nested xray optics in both full-shell and segmented configurations. The analytical infrastructure for this effort also lends itself to investigation of active strategies. We expect that a consequence of active figure control on relatively thin substrates is that errors are propagated to the edges, where they might affect the effective precision of the mounting points. Based upon modeling, we describe parametrically, the conditions under which active mounts are preferred over fixed ones, and the effect of active figure corrections on the required number, locations, and kinematic characteristics of mounting points.

Smart Cards for Transit : Multi-Use Remotely Interrogated Stored-Data Cards for Fare and Toll Payment

Science.gov (United States)

1995-04-01

This project developed relevant information on existing and future, stored readable/writable data card technology for fare and toll payments. The project supports the FTA objective of developing a plan for a common standard card-based fare payment sy...

[Does the mounting of gastrointestinal biopsies on millipore filter contribute to an improved section quality?

DEFF Research Database (Denmark)

Asmussen, L.; Bernstein, I.; Matzen, P.

2009-01-01

orientation, GIB is occasionally mounted on millipore filter (MF) in an attempt to place the deep cut side onto the MF. The importance of this technique for section quality is evaluated in this study. MATERIAL AND METHOD: The material comprised three consecutive series of GIB (60 gastric, duodenal......, and colorectal GIB, respectively). Sections were grouped in MF-mounted versus non-mounted GIB, the proportion of fully acceptable sections among mounted versus non-mounted GIB was recorded. RESULTS: 77.2% of all GIBs were MF-mounted. 33.1% of mounted GIBs versus 48.8% of non-mounted GIBs were assessed as fully...... acceptable sections. The differences between these figures are not statistically significant. 41.7% of the mounted GIBs were placed with the mucosal surface facing the MF, which entails a risk of damaging the tissue. CONCLUSION: MF-mounting of GIB did not contribute to section quality. Since the handling...

Mount Protects Thin-Walled Glass or Ceramic Tubes from Large Thermal and Vibration Loads

Science.gov (United States)

Amato, Michael; Schmidt, Stephen; Marsh. James; Dahya, Kevin

2011-01-01

The design allows for the low-stress mounting of fragile objects, like thin walled glass, by using particular ways of compensating, isolating, or releasing the coefficient of thermal expansion (CTE) differences between the mounted object and the mount itself. This mount profile is lower than true full kinematic mounting. Also, this approach enables accurate positioning of the component for electrical and optical interfaces. It avoids the higher and unpredictable stress issues that often result from potting the object. The mount has been built and tested to space-flight specifications, and has been used for fiber-optic, optical, and electrical interfaces for a spaceflight mission. This mount design is often metal and is slightly larger than the object to be mounted. The objects are optical or optical/electrical, and optical and/or electrical interfaces are required from the top and bottom. This requires the mount to be open at both ends, and for the object s position to be controlled. Thin inside inserts at the top and bottom contact the housing at defined lips, or edges, and hold the fragile object in the mount. The inserts can be customized to mimic the outer surface of the object, which further reduces stress. The inserts have the opposite CTE of the housing material, partially compensating for the CTE difference that causes thermal stress. A spring washer is inserted at one end to compensate for more CTE difference and to hold the object against the location edge of the mount for any optical position requirements. The spring also ensures that any fiber-optic or optic interface, which often requires some pressure to ensure a good interface, does not overstress the fragile object. The insert thickness, material, and spring washer size can be traded against each other to optimize the mount and stresses for various thermal and vibration load ranges and other mounting requirements. The alternate design uses two separate, unique features to reduce stress and hold the

Toll-like receptors as targets for inflammation, development and repair in the central nervous system

NARCIS (Netherlands)

Noort, J.M. van

2007-01-01

Toll-like receptors (TLRs) that play key roles in inflammation are also widely expressed in the CNS. While they are well known to activate inflammatory responses to microbial products, TLRs fulfill additional roles in the absence of infection. Emerging evidence suggests that several TLRs play a role

Control of Wall Mounting Robot

DEFF Research Database (Denmark)

Sloth, Christoffer; Pedersen, Rasmus

2017-01-01

This paper presents a method for designing controllers for trajectory tracking with actuator constraints. In particular, we consider a joystick-controlled wall mounting robot called WallMo. In contrast to previous works, a model-free approach is taken to the control problem, where the path...

Preparation of Samples for Leaf Architecture Studies, A Method for Mounting Cleared Leaves

Directory of Open Access Journals (Sweden)

Alejandra Vasco

2014-09-01

Full Text Available Premise of the study: Several recent waves of interest in leaf architecture have shown an expanding range of approaches and applications across a number of disciplines. Despite this increased interest, examination of existing archives of cleared and mounted leaves shows that current methods for mounting, in particular, yield unsatisfactory results and deterioration of samples over relatively short periods. Although techniques for clearing and staining leaves are numerous, published techniques for mounting leaves are scarce. Methods and Results: Here we present a complete protocol and recommendations for clearing, staining, and imaging leaves, and, most importantly, a method to permanently mount cleared leaves. Conclusions: The mounting protocol is faster than other methods, inexpensive, and straightforward; moreover, it yields clear and permanent samples that can easily be imaged, scanned, and stored. Specimens mounted with this method preserve well, with leaves that were mounted more than 35 years ago showing no signs of bubbling or discoloration.

Wildlife forensic entomology: determining time of death in two illegally killed black bear cubs.

Science.gov (United States)

Anderson, G S

1999-07-01

Forensic entomology is now commonly used to determine time of death in human death investigations. However, it can be equally applicable to wildlife crimes. This paper describes the use of entomology to determine time of death in the illegal killing of two young bear cubs in Manitoba, Canada. Two cubs were found shot, disemboweled, with their gall bladders removed. Natural Resource officers (Conservation Officers) and a Royal Canadian Mounted Police (R.C.M.P.) officer examined the remains, and the R.C.M.P. officer collected insect evidence. The only insects on the remains were adult blow flies coming to lay eggs and the blow fly eggs themselves (Diptera: Calliphoridae). The time of hatch was recorded and the insects were reared to adulthood. Time of hatch, together with species identification, macro and micro climate and lab developmental data were used to determine the time of death. The time was consistent with the time that the defendants were seen at the scene and was used in their conviction. This case illustrates that insect evidence can be equally as valuable in poaching cases as in homicide cases. However, in most cases Conservation Officers are unaware of this science. It is therefore, extremely important for more Conservation Officers to be educated about this field.

Role of toll like receptors in bacterial and viral diseases – A ...

African Journals Online (AJOL)

Avishek Das

2017-05-20

May 20, 2017 ... Background: Toll like receptors are key-receptors of the innate immune system, but their role against bacterial and viral infections are yet to be understood. Aim: The present study is aimed to investigate the diversity and frequency distribution of 10 TLR genes among typhoid fever and HIV+ patients. In this ...

CMS ECAL Endcap (EE) Dee Assembly - SC mounting on Dee 1

CERN Multimedia

Cockerill, D

2007-01-01

Protection panels on back of Dee 1, Completion of SC mounting, 03/10/2007: Completion of SC mounting (aart from the inner 3-2-1)on the first quadrant of Dee 1 and subsequent survey. 22-28/08/2007: The first supercrystals on Dee1, Dee1 in 867 with the first column of SCs ready for mounting, Dee1 with its protection panels over the laser monitoring fibre system

Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury

OpenAIRE

Fang, Huang; Wang, Peng-Fei; Zhou, Yu; Wang, Yan-Chun; Yang, Qing-Wu

2013-01-01

Intracerebral hemorrhage (ICH) is a common type of fatal stroke, accounting for about 15% to 20% of all strokes. Hemorrhagic strokes are associated with high mortality and morbidity, and increasing evidence shows that innate immune responses and inflammatory injury play a critical role in ICH-induced neurological deficits. However, the signaling pathways involved in ICH-induced inflammatory responses remain elusive. Toll-like receptor 4 (TLR4) belongs to a large family of pattern recognition ...

Solar electricity potentials and optimal angles for mounting solar ...

African Journals Online (AJOL)

The need for harnessing solar energy using solar panels mounted at optimal inclination angles in the six geopolitical zones of Nigeria is presented. The optimal angle for mounting solar panels as presented by Photovoltaic Geographic Information System (PVGIS) ranges from 11º to 14º in the Southern zone and 13º to 16º ...

Wind instrument mountings for above-the-cab lookout exposure

Science.gov (United States)

Owen P. Cramer; Ralph H. Moltzau

1968-01-01

The lookout tower offers a ready-made platform from which the speed of true unobstructed wind can be measured, then reduced to equivalent of 20-foot wind. Tower-mounted instruments must meet the requirements of a lightning conductor system, but should also be easily installed and removed for storage and maintenance. Lightweight aluminum mountings for catwalk or flat-...

Mount St. Helens aerosol evolution

Energy Technology Data Exchange (ETDEWEB)

Oberbeck, V.R.; Farlow, N.H.

1982-08-01

Stratospheric aerosol samples were collected using a wire impactor during the year following the eruption of Mount St. Helens. Analysis of samples shows that aerosol volume increased for 6 months due to gas-to-particle conversion and then decreased to background levels in the following 6 months.

Male-Male Mounting Behaviour in Free-Ranging Golden Snub-Nosed Monkeys (Rhinopithecus roxellana).

Science.gov (United States)

Fang, Gu; Dixson, Alan F; Qi, Xiao-Guang; Li, Bao-Guo

2018-01-01

An all-male band of golden snub-nosed monkeys (Rhinopithecus roxellana) was observed for 3 months in the Qinling Mountains of China, in order to collect data on the frequencies and contextual significance of male-male mounting behaviour. Mounts occurred in a variety of affiliative, dominance-related and sexual contexts, which differed depending upon the ages of the males involved. Mounting behaviour in this group was mainly initiated by adults. Juveniles mounted each other in affiliative contexts (during play and prior to grooming). Adult males mounted subadult and juvenile partners in a greater variety of sociosexual contexts (dominance/rank-related interactions; reconciliation following agonistic encounters, and sometimes as a prelude to receiving grooming). However, subadults and juveniles were never observed to mount adults. In one dyad, involving an adult male and a subadult partner, mounting was more frequent and prolonged, and included bouts of deep pelvic thrusting. Two mounts resulted in anal intromissions and, in 1 case, the subadult partner exhibited seminal emission. Given that the study took place during the annual mating peak period of R. roxellana, it is possible that this unusual male-male sexual activity was related to the absence of mating opportunities for those adults that were excluded from 1-male units. © 2018 S. Karger AG, Basel.

Two-sensor control in active vibration isolation using hard mounts

NARCIS (Netherlands)

Beijen, M.A.; Tjepkema, D.; van Dijk, J.

To isolate precision machines from floor vibrations, active vibration isolators are often applied. In this paper, a two-sensor control strategy, based on acceleration feedback and force feedback, is proposed for an active vibration isolator using a single-axis active hard mount. The hard mount

Two-sensor control in active vibration isolation using hard mounts

NARCIS (Netherlands)

Beijen, M.A.; Tjepkema, D.; van Dijk, Johannes

2014-01-01

To isolate precision machines from floor vibrations, active vibration isolators are often applied. In this paper, a two-sensor control strategy, based on acceleration feedback and force feedback, is proposed for an active vibration isolator using a single-axis active hard mount. The hard mount

Online Education as a Toll Good: An Examination of the South Carolina Virtual School Program

Science.gov (United States)

Rauh, Jonathan

2011-01-01

Education has long been considered merit good; however, inequitable distribution has made it more akin to a toll good. This was most recently demonstrated by Henry, Fortner, and Thompson (2010). Choice requirements designed to remedy the inequitable distribution of education, have largely been confined to brick and mortar schools. Subsequently,…

TOLL-LIKE RECEPTORS IN FAT BODY AND SALIVARY GLAND TISSUES IN THE CATTLE TICK Rhipicephalus microplus

Directory of Open Access Journals (Sweden)

Sabrina Rita da Fonseca Rezende

2016-11-01

Full Text Available ABSTRACT. Rezende S.deF., Fontenele M.R., Masuda C.A., de Oliveira P.L., Araujo H.M.M., Bittencourt V.R.E.P. & Leite M.de S. Toll-like receptors in fat body and salivary gland tissues in the cattle tick Rhipicephalus microplus. [Receptores Toll-like em corpo gorduroso e glândula salivar do carrapato bovino Rhipicephalus microplus]. Revista Brasileira de Medicina Veterinária, 38(supl. 3:47-53, 2016. Programa de Pós-Graduação em Ciências Veterinárias, Anexo 1, Instituto de Veterinária, Universidade Federal Rural do Estado do Rio de Janeiro, BR 465, KM 47, Seropédica, RJ 23890-000, Brasil. E-mail: milaneleite@ufrrj.br Toll-like receptors (TLRs play an important role in the recognition of pathogen components and subsequent activation of the innate immune response, which then leads to development of immune responses. In arthropods the fat body and salivary glands are important organs in the defense system against invading pathogens. In this study, we identified for the first time the presence of TLRs in fat body and salivary gland tissues of cattle tick Rhipicephalus microplus. Our results show that the expression of TLRs in fat body tissue are not found in all cells, but is specific to some cell types, in salivary glands TLRs protein expression occur in acini structure. We suggest that immune pathways are active in both fat body and salivary glands in the tick. The potential use of TLRs as a target for vaccine formulations against is discussed.

Nozzle Mounting Method Optimization Based on Robot Kinematic Analysis

Science.gov (United States)

Chen, Chaoyue; Liao, Hanlin; Montavon, Ghislain; Deng, Sihao

2016-08-01

Nowadays, the application of industrial robots in thermal spray is gaining more and more importance. A desired coating quality depends on factors such as a balanced robot performance, a uniform scanning trajectory and stable parameters (e.g. nozzle speed, scanning step, spray angle, standoff distance). These factors also affect the mass and heat transfer as well as the coating formation. Thus, the kinematic optimization of all these aspects plays a key role in order to obtain an optimal coating quality. In this study, the robot performance was optimized from the aspect of nozzle mounting on the robot. An optimized nozzle mounting for a type F4 nozzle was designed, based on the conventional mounting method from the point of view of robot kinematics validated on a virtual robot. Robot kinematic parameters were obtained from the simulation by offline programming software and analyzed by statistical methods. The energy consumptions of different nozzle mounting methods were also compared. The results showed that it was possible to reasonably assign the amount of robot motion to each axis during the process, so achieving a constant nozzle speed. Thus, it is possible optimize robot performance and to economize robot energy.

Impact of mounting methods in computerized axiography on assessment of condylar inclination.

Science.gov (United States)

Schierz, Oliver; Wagner, Philipp; Rauch, Angelika; Reissmann, Daniel R

2017-08-30

Valid and reliable recording is a key requirement for accurately simulating individual jaw movements. Horizontal condylar inclination (HCI) and Bennett's angle were measured using a digital jaw tracker (Cadiax® Compact 2) in 27 young adults. Three mounting methods (paraocclusal tray adapter, periocclusal tray adapter, and tray adapter with mandibular clamp) were tested. The mean values of the HCI differed by up to 10° between the mounting methods; however, the values for Bennett's angle did not differ substantially. While the intersession reliability of the Bennett's angle assessment did not depend on the mounting method, the reliability of the HCI assessment was only fair to good for the paraocclusal mounting method but poor for both periocclusal mounting methods. For attaching the tracing bow of jaw trackers to the mandible, a paraocclusal tray adapter should be applied, to achieve the most reliable results.

Calculating the mounting parameters for Taylor Spatial Frame correction using computed tomography.

Science.gov (United States)

Kucukkaya, Metin; Karakoyun, Ozgur; Armagan, Raffi; Kuzgun, Unal

2011-07-01

The Taylor Spatial Frame uses a computer program-based six-axis deformity analysis. However, there is often a residual deformity after the initial correction, especially in deformities with a rotational component. This problem can be resolved by recalculating the parameters and inputting all new deformity and mounting parameters. However, this may necessitate repeated x-rays and delay treatment. We believe that error in the mounting parameters is the main reason for most residual deformities. To prevent these problems, we describe a new calculation technique for determining the mounting parameters that uses computed tomography. This technique is especially advantageous for deformities with a rotational component. Using this technique, exact calculation of the mounting parameters is possible and the residual deformity and number of repeated x-rays can be minimized. This new technique is an alternative method to accurately calculating the mounting parameters.

Astrophotography on the go using short exposures with light mounts

CERN Document Server

Ashley, Joseph

2015-01-01

No longer are heavy, sturdy, expensive mounts and tripods required to photograph deep space. With today's advances in technology, all that is required is an entry-DSLR and an entry level GoTo telescope. Here is all of the information needed to start photographing the night sky without buying expensive tracking mounts. By using multiple short exposures and combining them with mostly ‘freeware’ computer programs, the effect of image rotation can be minimized to a point where it is undetectable in normal astrophotography, even for a deep-sky object such as a galaxy or nebula. All the processes, techniques, and equipment needed to use inexpensive, lightweight altazimuth and equatorial mounts and very short exposures photography to image deep space objects are explained, step-by-step, in full detail, supported by clear, easy to understand graphics and photographs.   Currently available lightweight mounts and tripods are identified and examined from an economic versus capability perspective to help users deter...

Mounting power cables on SOLEIL

CERN Multimedia

Laurent Guiraud

1999-01-01

The power couplers are mounted on the SOLEIL cryomodule in a clean room. The cryomodule will allow superconducting technology to be used at SOLEIL, the French national synchrotron facility. This work is carried out as part of a collaboration between CERN and CEA Saclay, the French National Atomic Energy Commission.

Design of tracking mount and controller for mobile satellite laser ranging system

Science.gov (United States)

Park, Cheol Hoon; Son, Young Su; Kim, Byung In; Ham, Sang Young; Lee, Sung Whee; Lim, Hyung Chul

2012-01-01

In this study, we have proposed and implemented a design for the tracking mount and controller of the ARGO-M (Accurate Ranging system for Geodetic Observation - Mobile) which is a mobile satellite laser ranging (SLR) system developed by the Korea Astronomy and Space Science Institute (KASI) and Korea Institute of Machinery and Materials (KIMM). The tracking mount comprises a few core components such as bearings, driving motors and encoders. These components were selected as per the technical specifications for the tracking mount of the ARGO-M. A three-dimensional model of the tracking mount was designed. The frequency analysis of the model predicted that the first natural frequency of the designed tracking mount was high enough. The tracking controller is simulated using MATLAB/xPC Target to achieve the required pointing and tracking accuracy. In order to evaluate the system repeatability and tracking accuracy of the tracking mount, a prototype of the ARGO-M was fabricated, and repeatability tests were carried out using a laser interferometer. Tracking tests were conducted using the trajectories of low earth orbit (LEO) and high earth orbit (HEO) satellites. Based on the test results, it was confirmed that the prototype of the tracking mount and controller of the ARGO-M could achieve the required repeatability along with a tracking accuracy of less than 1 arcsec.

A Versatile Mounting Method for Long Term Imaging of Zebrafish Development.

Science.gov (United States)

Hirsinger, Estelle; Steventon, Ben

2017-01-26

Zebrafish embryos offer an ideal experimental system to study complex morphogenetic processes due to their ease of accessibility and optical transparency. In particular, posterior body elongation is an essential process in embryonic development by which multiple tissue deformations act together to direct the formation of a large part of the body axis. In order to observe this process by long-term time-lapse imaging it is necessary to utilize a mounting technique that allows sufficient support to maintain samples in the correct orientation during transfer to the microscope and acquisition. In addition, the mounting must also provide sufficient freedom of movement for the outgrowth of the posterior body region without affecting its normal development. Finally, there must be a certain degree in versatility of the mounting method to allow imaging on diverse imaging set-ups. Here, we present a mounting technique for imaging the development of posterior body elongation in the zebrafish D. rerio. This technique involves mounting embryos such that the head and yolk sac regions are almost entirely included in agarose, while leaving out the posterior body region to elongate and develop normally. We will show how this can be adapted for upright, inverted and vertical light-sheet microscopy set-ups. While this protocol focuses on mounting embryos for imaging for the posterior body, it could easily be adapted for the live imaging of multiple aspects of zebrafish development.

Births and deaths including fetal deaths

Data.gov (United States)

U.S. Department of Health & Human Services — Access to a variety of United States birth and death files including fetal deaths: Birth Files, 1968-2009; 1995-2005; Fetal death file, 1982-2005; Mortality files,...

Staging Death, Translating Death, Rehearsing Death: A Photographer’s Apprenticeship in Dying

Directory of Open Access Journals (Sweden)

Daniela Fargione

2010-10-01

Full Text Available The preponderance of death imagery in the mass media and a recent interest of photography in the practice of death suggest the need to reevaluate our approach to death and dying, especially when violence is involved. This essay is a case study of History of Violence, Claudio Cravero's last photographic project. His collection of "portraits" reproduce apparent dead bodies, mostly attacked in their own domestic spheres, but neither the perpetrator of death (a mysterious murderer?, nor the weapon used (an omnipresent knife, should be considered as main focal points of the artist's inquiry. The undoubtful protagonist of these photographs, instead, is the light, that illuminates fear: not of death itself, rather of the obnoxious indifference to it, as the result of generalized death imagery saturation.     The staged apparent death displayed in Cravero's photographs serve both as a memento mori and as a strategy to come to terms with the idea of death. In short, it is an apprentship in dying through a domesticating translation practice. Eventually, Cravero's History of Violence offers a complex reflection on the interplay between each individual story and macrolevel social History, thus providing some hypotheses of where violence and death fit in that odd geometry of time and space that we call life.

Implications of Dynamic Pressure Transducer Mounting Variations on Measurements in Pyrotechnic Test Apparatus

Science.gov (United States)

Dibbern, Andreas; Crisafulli, Jeffrey; Hagopia, Michael; McDougle, Stephen H.; Saulsberry, Regor L.

2009-01-01

Accurate dynamic pressure measurements are often difficult to make within small pyrotechnic devices, and transducer mounting difficulties can cause data anomalies that lead to erroneous conclusions. Delayed initial pressure response followed by data ringing has been observed when using miniaturized pressure transducer mounting adapters required to interface transducers to small test chambers. This delayed pressure response and ringing, combined with a high data acquisition rate, has complicated data analysis. This paper compares the output signal characteristics from different pressure transducer mounting options, where the passage distance from the transducer face to the pyrotechnic chamber is varied in length and diameter. By analyzing the data and understating the associated system dynamics, a more realistic understanding of the actual dynamic pressure variations is achieved. Three pressure transducer mounting configurations (elongated, standard, and face/flush mount) were simultaneously tested using NASA standard initiators in closed volume pressure bombs. This paper also presents results of these pressure transducer mounting configurations as a result of a larger NASA Engineering and Safety Center pyrovalve test project. Results from these tests indicate the improved performance of using face/flush mounted pressure transducers in this application. This type of mounting improved initial pressure measurement response time by approximately 19 s over standard adapter mounting, eliminating most of the lag time; provided a near step-function type initial pressure increase; and greatly reduced data ringing in high data acquisition rate systems. The paper goes on to discuss other issues associated with the firing and instrumentation that are important for the tester to understand.

Inverse axial mounting stiffness design for lithographic projection lenses.

Science.gov (United States)

Wen-quan, Yuan; Hong-bo, Shang; Wei, Zhang

2014-09-01

In order to balance axial mounting stiffness of lithographic projection lenses and the image quality under dynamic working conditions, an easy inverse axial mounting stiffness design method is developed in this article. Imaging quality deterioration at the wafer under different axial vibration levels is analyzed. The desired image quality can be determined according to practical requirements, and axial vibrational tolerance of each lens is solved with the damped least-squares method. Based on adaptive interval adjustment, a binary search algorithm, and the finite element method, the axial mounting stiffness of each lens can be traveled in a large interval, and converges to a moderate numerical solution which makes the axial vibrational amplitude of the lens converge to its axial vibrational tolerance. Model simulation is carried out to validate the effectiveness of the method.

A Portable Shoulder-Mounted Camera System for Surgical Education in Spine Surgery.

Science.gov (United States)

Pham, Martin H; Ohiorhenuan, Ifije E; Patel, Neil N; Jakoi, Andre M; Hsieh, Patrick C; Acosta, Frank L; Wang, Jeffrey C; Liu, John C

2017-02-07

The past several years have demonstrated an increased recognition of operative videos as an important adjunct for resident education. Currently lacking, however, are effective methods to record video for the purposes of illustrating the techniques of minimally invasive (MIS) and complex spine surgery. We describe here our experiences developing and using a shoulder-mounted camera system for recording surgical video. Our requirements for an effective camera system included wireless portability to allow for movement around the operating room, camera mount location for comfort and loupes/headlight usage, battery life for long operative days, and sterile control of on/off recording. With this in mind, we created a shoulder-mounted camera system utilizing a GoPro™ HERO3+, its Smart Remote (GoPro, Inc., San Mateo, California), a high-capacity external battery pack, and a commercially available shoulder-mount harness. This shoulder-mounted system was more comfortable to wear for long periods of time in comparison to existing head-mounted and loupe-mounted systems. Without requiring any wired connections, the surgeon was free to move around the room as needed. Over the past several years, we have recorded numerous MIS and complex spine surgeries for the purposes of surgical video creation for resident education. Surgical videos serve as a platform to distribute important operative nuances in rich multimedia. Effective and practical camera system setups are needed to encourage the continued creation of videos to illustrate the surgical maneuvers in minimally invasive and complex spinal surgery. We describe here a novel portable shoulder-mounted camera system setup specifically designed to be worn and used for long periods of time in the operating room.

Semi-active engine mount design using auxiliary magneto-rheological fluid compliance chamber

Science.gov (United States)

Mansour, H.; Arzanpour, S.; Golnaraghi, M. F.; Parameswaran, A. M.

2011-03-01

Engine mounts are used in the automotive industry to isolate engine and chassis by reducing the noise and vibration imposed from one to the other. This paper describes modelling, simulation and design of a semi-active engine mount that is designed specifically to address the complicated vibration pattern of variable displacement engines (VDE). The ideal isolation for VDE requires the stiffness to be switchable upon cylinder activation/deactivation operating modes. In order to have a modular design, the same hydraulic engine mount components are maintained and a novel auxiliary magneto-rheological (MR) fluid chamber is developed and retrofitted inside the pumping chamber. The new compliance chamber is a controllable pressure regulator, which can effectively alter the dynamic performance of the mount. Switching between different modes happens by turning the electrical current to the MR chamber magnetic coil on and off. A model has been developed for the passive hydraulic mount and then it is extended to include the MR auxiliary chamber as well. A proof-of-concept prototype of the design has been fabricated which validates the mathematical model. The results demonstrate unique capability of the developed semi-active mount to be used for VDE application.

Leukocytic Toll-Like Receptor 2 Deficiency Preserves Cardiac Function And Reduces Fibrosis In Sustained Pressure Overload

NARCIS (Netherlands)

Wang, Jiong-Wei; Fontes, Magda S. C.; Wang, Xiaoyuan; Chong, Suet Yen; Kessler, Elise L.; Zhang, Ya-Nan; de Haan, Judith J.; Arslan, Fatih; de Jager, Saskia C. A.; Timmers, Leo; van Veen, Toon A. B.; Lam, Carolyn S. P.; de Kleijn, Dominique P. V.

2017-01-01

An involement of Toll-like receptor 2 (TLR2) has been established in cardiac dysfunction after acute myocardial infarction; however, its role in chronic pressure overload is unclear. We sought to evaluate the role of TLR2 in cardiac hypertrophy, fibrosis and dysfunction in sustained pressure

Vertically mounted bifacial photovoltaic modules: A global analysis

International Nuclear Information System (INIS)

Guo, Siyu; Walsh, Timothy Michael; Peters, Marius

2013-01-01

Bifacial PV (photovoltaic) modules have recently come to increasing attention and various system designs have been investigated. In this paper, a global comparison is made between vertically mounted bifacial modules facing East–West and conventionally mounted mono-facial modules. An analytical method is used to calculate the radiation received by these two module configurations. It is found that the answer to the question which of these two module configurations performs better strongly depends on three factors: (i) the latitude, (ii) the local diffuse fraction and (iii) the albedo. In a subsequent part of the paper, the minimum albedo required to result in a better performance for vertically mounted bifacial modules is calculated for every place in the world. The calculation is based on measured data of the diffuse light fraction and the results are shown in the form of a global map. Finally, the albedo requirements are compared with the measured global albedo distribution. The calculation allows a distinct decision which module configuration is more suitable for a certain place in the world. The result is also shown as a map defining the corresponding areas. - Highlights: • Vertically mounted bifacial module and conventionally monofacial module are compared. • The key factors affecting the performance of the two configurations are investigated. • Which module configuration is more suitable for each place is shown in a world map. • The minimum albedo for bifacial modules to have a better performance is calculated

A Study on quality improvement and application technology in pad-mounted transformers

Energy Technology Data Exchange (ETDEWEB)

Kim, Soon Tae; Mun, Kyung Hwa; Jung, Dong Won; Kim, Sang Jun; Lee, Nam Woo; Kang, Nae Kuk; Kim, Dong Mung [Korea Electric Power Corp. (KEPCO), Taejon (Korea, Republic of). Research Center; Kim, Kwang Ha; Kang, Young Sik; Lee, Woo Young; Lyu, Hee Suk; Sun, Jong Ho; Lyu, Hyung Ki; Kim, Yik Soo; Park, Sung Jae; Kim, Won Ho [Korea Electrotechnology Research Inst., Changwon (Korea, Republic of)

1995-12-31

In order to increase the reliability of pad-mounted transformers, the authors investigated operating condition of pad-mounted transformers and understood their failure mechanisms. The objective of their study was to improve quality and operating condition and install switches to be able to check and maintain transformers and optimise protection devices and increase cooling effect in pad-mounted transformers (author). 65 refs., 130 figs.

GENES, IN ADDITION TO TOLL-LIKE RECEPTOR 2, PLAY A ROLE IN ANTIBACTERIAL DEFENSE TO STREPTOCOCCAL PNEUMONIA

Science.gov (United States)

Streptococcus infection in human populations continues to be a major cause of morbidity and mortality. To evaluate the effect of genetic background and toll-like receptor 2 (TLR2) on antibacterial defense to streptococcal infection, eight genetically diverse strains of mic...

Preparation of samples for leaf architecture studies, a method for mounting cleared leaves1

Science.gov (United States)

Vasco, Alejandra; Thadeo, Marcela; Conover, Margaret; Daly, Douglas C.

2014-01-01

• Premise of the study: Several recent waves of interest in leaf architecture have shown an expanding range of approaches and applications across a number of disciplines. Despite this increased interest, examination of existing archives of cleared and mounted leaves shows that current methods for mounting, in particular, yield unsatisfactory results and deterioration of samples over relatively short periods. Although techniques for clearing and staining leaves are numerous, published techniques for mounting leaves are scarce. • Methods and Results: Here we present a complete protocol and recommendations for clearing, staining, and imaging leaves, and, most importantly, a method to permanently mount cleared leaves. • Conclusions: The mounting protocol is faster than other methods, inexpensive, and straightforward; moreover, it yields clear and permanent samples that can easily be imaged, scanned, and stored. Specimens mounted with this method preserve well, with leaves that were mounted more than 35 years ago showing no signs of bubbling or discoloration. PMID:25225627

Andrographolide suppresses TRIF-dependent signaling of toll-like receptors by targeting TBK1.

Science.gov (United States)

Kim, Ah-Yeon; Shim, Hyun-Jin; Shin, Hyeon-Myeong; Lee, Yoo Jung; Nam, Hyeonjeong; Kim, Su Yeon; Youn, Hyung-Sun

2018-04-01

Toll-like receptors (TLRs) play a crucial role in danger recognition and induction of innate immune response against bacterial and viral infections. The TLR adaptor molecule, toll-interleukin-1 receptor domain-containing adapter inducing interferon-β (TRIF), facilitates TLR3 and TLR4 signaling, leading to the activation of the transcription factor, NF-κB and interferon regulatory factor 3 (IRF3). Andrographolide, the active component of Andrographis paniculata, exerts anti-inflammatory effects; however, the principal molecular mechanisms remain unclear. The objective of this study was to investigate the role of andrographolide in TLR signaling pathways. Andrographolide suppressed NF-κB activation as well as COX-2 expression induced by TLR3 or TLR4 agonists. Andrographolide also suppressed the activation of IRF3 and the expression of interferon inducible protein-10 (IP-10) induced by TLR3 or TLR4 agonists. Andrographolide attenuated ligand-independent activation of IRF3 following overexpression of TRIF, TBK1, or IRF3. Furthermore, andrographolide inhibited TBK1 kinase activity in vitro. These results indicate that andrographolide modulates the TRIF-dependent pathway of TLRs by targeting TBK1 and represents a potential new anti-inflammatory candidate. Copyright © 2018 Elsevier B.V. All rights reserved.

Toll-like receptors and NOD-like receptors in rheumatic diseases.

LENUS (Irish Health Repository)

McCormack, William J

2012-02-01

The past 10 years have seen the description of families of receptors that drive proinflammatory cytokine production in infection and tissue injury. Two major classes have been examined in the context of inflammatory joint disease--the Toll-like receptors (TLRs) and NOD-like receptors (NLRs). TLRs such as TLR2 and TLR4 are being implicated in the pathology of rheumatoid arthritis, ankylosing spondylitis, lyme arthritis and osteoarthritis. Nalp3 has been identified as a key NLR for IL-1beta production and has been shown to have a particular role in gout. These findings present new therapeutic opportunities, possibly allowing for the replacement of biologics with small molecule inhibitors.

Shock Mounting for Heavy Machines

Science.gov (United States)

Thompson, A. R.

1984-01-01

Elastomeric bearings eliminate extraneous forces. Rocket thrust transmitted from motor to load cells via support that absorbs extraneous forces so they do not affect accuracy of thrust measurements. Adapter spoked cone fits over forward end of rocket motor. Shock mounting developed for rocket engines under test used as support for heavy machines, bridges, or towers.

Square Van Atta reflector with conducting mounting flame

DEFF Research Database (Denmark)

Nielsen, Erik Dragø

1970-01-01

A theoretical and numerical analysis of square Van Atta reflectors has been carried out with or without a conducting plate, used for mounting of the antenna elements. The Van Atta reflector investigated has antenna elements which are parallel half-wave dipoles interconnected in pairs by transmiss......A theoretical and numerical analysis of square Van Atta reflectors has been carried out with or without a conducting plate, used for mounting of the antenna elements. The Van Atta reflector investigated has antenna elements which are parallel half-wave dipoles interconnected in pairs...

The seed plant flora of the Mount Jinggangshan region, southeastern China.

Directory of Open Access Journals (Sweden)

Lei Wang

Full Text Available The Mount Jinggangshan region is located between Jiangxi and Hunan provinces in southeastern China in the central section of the Luoxiao Mountains. A detailed investigation of Mount Jinggangshan region shows that the seed plant flora comprises 2,958 species in 1,003 genera and 210 families (Engler's system adjusted according to Zhengyi Wu's concept. Among them, 23 species of gymnospermae belong to 17 genera and 9 families, and 2,935 species of angiosperms are in 986 genera and 201 families. Moreover, they can also be sorted into woody plants (350 genera and 1,295 species and herbaceous plants (653 genera and 1,663 species. The dominant families are mainly Fagaceae, Lauraceae, Theaceae, Hamamelidaceae, Magnoliaceae, Ericaceae, Styracaceae, Aquifoliaceae, Elaeocarpaceae, Aceraceae, Rosaceae, Corylaceae, Daphniphyllaceae, Symplocaceae, Euphorbiaceae, Pinaceae, Taxodiaceae, Cupressaceae and Taxaceae. Ancient and relic taxa include Ginkgo biloba, Fokieniahodginsii, Amentotaxusargotaenia, Disanthuscercidifolia subsp. longipes, Hamamelismollis, Manglietiafordiana, Magnoliaofficinalis, Tsoongiodendronodorum, Fortuneariasinensis, Cyclocaryapaliurus, Eucommiaulmoides, Sargentodoxacuneata, Bretschneiderasinensis, Camptothecaacuminata, Tapisciasinensis, etc. The flora of Mount Jinggangshan region includes 79 cosmopolitan genera and 924 non-cosmopolitan genera, which are 7.88% and 92.12% of all genera. The latter includes 452 tropical genera (48.92% and 472 temperate genera (51.08%. The temperate elements include 44 genera endemic to China, accounting for 4.76% of all genera. Among 1,003 genera, 465 have only a single species and 401 are oligotypic genera (with 2-5 species. These genera account for 86.34% of all genera. The floristic analysis indicates that the flora of Mount Jinggangshan region is closely related to the flora of Mount Wuyishan region in southeastern China. The flora of Mount Jinggangshan region also contains many elements of central and

A method of mounting multiple otoliths for beam-based microchemical analyses

Science.gov (United States)

Donohoe, C.J.; Zimmerman, C.E.

2010-01-01

Beam-based analytical methods are widely used to measure the concentrations of elements and isotopes in otoliths. These methods usually require that otoliths be individually mounted and prepared to properly expose the desired growth region to the analytical beam. Most analytical instruments, such as LA-ICPMS and ion and electron microprobes, have sample holders that will accept only one to six slides or mounts at a time. We describe a method of mounting otoliths that allows for easy transfer of many otoliths to a single mount after they have been prepared. Such an approach increases the number of otoliths that can be analyzed in a single session by reducing the need open the sample chamber to exchange slides-a particularly time consuming step on instruments that operate under vacuum. For ion and electron microprobes, the method also greatly reduces the number of slides that must be coated with an electrical conductor prior to analysis. In this method, a narrow strip of cover glass is first glued at one end to a standard microscope slide. The otolith is then mounted in thermoplastic resin on the opposite, free end of the strip. The otolith can then be ground and flipped, if needed, by reheating the mounting medium. After otolith preparation is complete, the cover glass is cut with a scribe to free the otolith and up to 20 small otoliths can be arranged on a single petrographic slide. ?? 2010 The Author(s).

Using wintergreen oil for mounting mosquito larvae: a safer alternative to xylene.

Science.gov (United States)

Koay, J B; Natasya, N N; Nashithatul, Mag; Ihsanuddin, R; Salleh, F M; Azil, A H

2016-01-01

Permanent mounting of fourth instar mosquito larvae is essential for identifying Aedes spp. This procedure requires extensive exposure to xylene, a clearing agent in the mounting process. We investigated wintergreen oil as a substitute for xylene. Five hundred larvae were mounted on slides to evaluate shrinkage or expansion of specimens after clearing using xylene or wintergreen oil. We examined the ventral brush and siphonal hair tufts for species identification and for preservation of morphological characteristics after clearing specimens in xylene or wintergreen oil. Shrinkage of the length of whole larvae and width of the head, thorax and abdomen after mounting was significantly greater after clearing with xylene than with wintergreen oil. The length of the comb scale nearest the ventral brush was similar for both clearing agents. The clarity of the specimens after mounting was improved by clearing with wintergreen oil, but the integrity of the ventral brush and siphonal hair tufts were similar for both clearing agents.

Toll-like receptors as therapeutic targets in cystic fibrosis.

LENUS (Irish Health Repository)

Greene, Catherine M

2008-12-01

Background: Toll-like receptors (TLRs) are pattern recognition receptors that act as a first-line of defence in the innate immune response by recognising and responding to conserved molecular patterns in microbial factors and endogenous danger signals. Cystic fibrosis (CF)-affected airways represent a milieu potentially rich in TLR agonists and the chronic inflammatory phenotype evident in CF airway epithelial cells is probably due in large part to activation of TLRs. Objective\\/methods: To examine the prospects of developing novel therapies for CF by targeting TLRs. We outline the expression and function of TLRs and explore the therapeutic potential of naturally-occurring and synthetic TLR inhibitors for CF. Results\\/conclusion: Modulation of TLRs has therapeutic potential for the inflammatory lung manifestations of CF.

Toll-Like Receptors 2 and 3 Agonists Differentially Affect Oligodendrocyte Survival, Differentiation, and Myelin Membrane Formation

NARCIS (Netherlands)

Bsibsi, Malika; Nomden, Anita; van Noort, Johannes M.; Baron, Wia

Toll-like receptors (TLRs) play a key role in controlling innate immune responses to a wide variety of pathogen-associated molecules as well as endogenous signals. In addition, TLR expression within nonimmune cells has been recognized as as modulator of cell behavior. In this study we have addressed

June 1992 Mount Spurr, USA Images

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Following 39 years of inactivity, Crater Peak vent on the south flank of Mount Spurr volcano burst into eruption at 7:04 a.m. Alaska daylight time (ADT) on June 27,...

Real-time electrocardiogram transmission from Mount Everest during continued ascent.

Science.gov (United States)

Kao, Wei-Fong; Huang, Jyh-How; Kuo, Terry B J; Chang, Po-Lun; Chang, Wen-Chen; Chan, Kuo-Hung; Liu, Wen-Hsiung; Wang, Shih-Hao; Su, Tzu-Yao; Chiang, Hsiu-chen; Chen, Jin-Jong

2013-01-01

The feasibility of a real-time electrocardiogram (ECG) transmission via satellite phone from Mount Everest to determine a climber's suitability for continued ascent was examined. Four Taiwanese climbers were enrolled in the 2009 Mount Everest summit program. Physiological measurements were taken at base camp (5300 m), camp 2 (6400 m), camp 3 (7100 m), and camp 4 (7950 m) 1 hour after arrival and following a 10 minute rest period. A total of 3 out of 4 climbers were able to summit Mount Everest successfully. Overall, ECG and global positioning system (GPS) coordinates of climbers were transmitted in real-time via satellite phone successfully from base camp, camp 2, camp 3, and camp 4. At each camp, Resting Heart Rate (RHR) was transmitted and recorded: base camp (54-113 bpm), camp 2 (94-130 bpm), camp 3 (98-115 bpm), and camp 4 (93-111 bpm). Real-time ECG and GPS coordinate transmission via satellite phone is feasible for climbers on Mount Everest. Real-time RHR data can be used to evaluate a climber's physiological capacity to continue an ascent and to summit.

75 FR 67388 - Credit Watch Termination Initiative; Termination of Direct Endorsement (DE) Approval

Science.gov (United States)

2010-11-02

... toll-free number). Persons with hearing or speech impairments may access that number through TTY by... Office Termination Mortgagee name address jurisdictions effective date Homeownership centers Freedom.... Freedom Mortgage Corp......... 907 Pleasant Valley Des Moines....... 10/4/10 Denver. Ave. Mount Laurel, NJ...

Design and vibration control of vehicle engine mount activated by MR fluid and piezoelectric actuator

Science.gov (United States)

Lee, D. Y.; Park, Y. K.; Choi, S. B.; Lee, H. G.

2009-07-01

An engine is one of the most dominant noise and vibration sources in vehicle systems. Therefore, in order to resolve noise and vibration problems due to engine, various types of engine mounts have been proposed. This work presents a new type of active engine mount system featuring a magneto-rheological (MR) fluid and a piezostack actuator. As a first step, six degrees-of freedom dynamic model of an in-line four-cylinder engine which has three points mounting system is derived by considering the dynamic behaviors of MR mount and piezostack mount. In the configuration of engine mount system, two MR mounts are installed for vibration control of roll mode motion whose energy is very high in low frequency range, while one piezostack mount is installed for vibration control of bounce and pitch mode motion whose energy is relatively high in high frequency range. As a second step, linear quadratic regulator (LQR) controller is synthesized to actively control the imposed vibration. In order to demonstrate the effectiveness of the proposed active engine mount, vibration control performances are evaluated under various engine operating speeds (wide frequency range).

Neonatal Death

Science.gov (United States)

... Home > Complications & Loss > Loss & grief > Neonatal death Neonatal death E-mail to a friend Please fill in ... cope with your baby’s death. What is neonatal death? Neonatal death is when a baby dies in ...

The machinery of Nod-like receptors: refining the paths to immunity and cell death.

Science.gov (United States)

Saleh, Maya

2011-09-01

One of the fundamental aspects of the innate immune system is its capacity to discriminate between self and non-self or altered self, and to quickly respond by eliciting effector mechanisms that act in concert to restore normalcy. This capacity is determined by a set of evolutionarily conserved pattern recognition receptors (PRRs) that sense the presence of microbial motifs or endogenous danger signals, including tissue damage, cellular transformation or metabolic perturbation, and orchestrate the nature, duration and intensity of the innate immune response. Nod-like receptors (NLRs), a group of intracellular PRRs, are particularly essential as evident by the high incidence of genetic variations in their genes in various diseases of homeostasis. Here, I overview the signaling mechanisms of NLRs and discuss the mounting evidence of evolutionary conservation between their pathways and the cell death machinery. I also describe their effector functions that link the sensing of danger to the induction of inflammation, autophagy or cell death. © 2011 John Wiley & Sons A/S.

Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro

Directory of Open Access Journals (Sweden)

Mei Yang

2017-10-01

Full Text Available Necrotic cell death is a hallmark feature of ischemic stroke and it may facilitate inflammation by releasing intracellular components after cell-membrane rupture. Previous studies reported that β-caryophyllene (BCP mitigates cerebral ischemia-reperfusion (I/R injury, but the underlying mechanism remains unclear. We explored whether BCP exerts a neuroprotective effect in cerebral I/R injury through inhibiting necroptotic cell death and inflammation. Primary neurons with and without BCP (0.2, 1, 5, 25 μM treatment were exposed to oxygen-glucose deprivation and re-oxygenation (OGD/R. Neuron damage, neuronal death type and mixed lineage kinase domain-like (MLKL protein expression were assessed 48 h after OGD/R. Furthermore, mice underwent I/R procedures with or without BCP (8, 24, 72 mg/kg, ip.. Neurologic dysfunction, cerebral infarct volumes, cell death, cytokine levels, necroptosis core molecules, and HMGB1-TLR4 signaling were determined at 48 h after I/R. BCP (5 μM significantly reduced necroptotic neurons and MLKL protein expression following OGD/R. BCP (24, 72 mg/kg, ip. reduced infarct volumes, neuronal necrosis, receptor-interaction protein kinase-1 (RIPK1, receptor-interaction protein kinase-3 (RIPK3 expression, and MLKL phosphorylation after I/R injury. BCP also decreased high-mobility group box 1 (HMGB1, toll-like receptor 4 (TLR4, interleukin-1β (IL-1β, and tumor necrosis factor-α (TNF-α levels. Thus, BCP alleviates ischemic brain damage potentially by inhibiting necroptotic neuronal death and inflammatory response. This study suggests a novel application for BCP as a neuroprotective agent.

Dynamic characteristics of mirrors' kinematic mount

International Nuclear Information System (INIS)

Wu Wenkai; Du Qiang; Li Jingze; Chen Gang; Chen Xiaojuan; Xu Yuanli

2002-01-01

Applying exact constrain design principles, kinematic mount for precision positioning large aperture mirrors is designed; theoretical method is introduced to analyze its dynamic characteristics and the result of the experiment for mirrors, stability; accordingly, the methods to improve design are put forward

Death Cafe.

Science.gov (United States)

Miles, Lizzy; Corr, Charles A

2017-06-01

This article explains the meaning of the phrase Death Cafe and describes what typically occurs at a Death Cafe gathering. The article traces the history of the Death Cafe movement, explores some reasons why people take part in a Death Cafe gathering, and gives examples of what individuals think they might derive from their participation. In addition, this article notes similarities between the Death Cafe movement and three other developments in the field of death, dying, and bereavement. Finally, this article identifies two provisional lessons that can be drawn from Death Cafe gatherings and the Death Cafe movement itself.

Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators

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Lucía Pérez-Regidor

2016-09-01

Full Text Available This review aims to summarize the latest efforts performed in the search for novel chemical entities such as Toll-like receptor (TLR modulators by means of virtual screening techniques. This is an emergent research field with only very recent (and successful contributions. Identification of drug-like molecules with potential therapeutic applications for the treatment of a variety of TLR-regulated diseases has attracted considerable interest due to the clinical potential. Additionally, the virtual screening databases and computational tools employed have been overviewed in a descriptive way, widening the scope for researchers interested in the field.

The preliminary results: Internal seismic velocity structure imaging beneath Mount Lokon

Energy Technology Data Exchange (ETDEWEB)

Firmansyah, Rizky, E-mail: rizkyfirmansyah@hotmail.com [Geophysical Engineering, Faculty of Mining and Petroleum Engineering, Institut Teknologi Bandung, Bandung, 40132 (Indonesia); Nugraha, Andri Dian, E-mail: nugraha@gf.itb.ac.id [Global Geophysical Group, Faculty of Mining and Petroleum Engineering, Institut Teknologi Bandung, Bandung, 40132 (Indonesia); Kristianto, E-mail: kris@vsi.esdm.go.id [Center for Volcanology and Geological Hazard Mitigation (CVGHM), Geological Agency, Bandung, 40122 (Indonesia)

2015-04-24

Historical records that before the 17{sup th} century, Mount Lokon had been dormant for approximately 400 years. In the years between 1350 and 1400, eruption ever recorded in Empung, came from Mount Lokon’s central crater. Subsequently, in 1750 to 1800, Mount Lokon continued to erupt again and caused soil damage and fall victim. After 1949, Mount Lokon dramatically increased in its frequency: the eruption interval varies between 1 – 5 years, with an average interval of 3 years and a rest interval ranged from 8 – 64 years. Then, on June 26{sup th}, 2011, standby alert set by the Center for Volcanology and Geological Hazard Mitigation. Peak activity happened on July 4{sup th}, 2011 that Mount Lokon erupted continuously until August 28{sup th}, 2011. In this study, we carefully analyzed micro-earthquakes waveform and determined hypocenter location of those events. We then conducted travel time seismic tomographic inversion using SIMULPS12 method to detemine Vp, Vs and Vp/Vs ratio structures beneath Lokon volcano in order to enhance our subsurface geological structure. During the tomographic inversion, we started from 1-D seismic velocities model obtained from VELEST33 method. Our preliminary results show low Vp, low Vs, and high Vp/Vs are observed beneath Mount Lokon-Empung which are may be associated with weak zone or hot material zones. However, in this study we used few station for recording of micro-earthquake events. So, we suggest in the future tomography study, the adding of some seismometers in order to improve ray coverage in the region is profoundly justified.

The influence of (toll-related) travel costs in residential location decisions of households : A stated choice approach

NARCIS (Netherlands)

Tillema, T.; van Wee, B.; Ettema, D.

2010-01-01

In this paper, we investigate the impact of travel costs, in particular toll costs, on the residential location choice of households, using a stated choice survey. Within the stated choice experiment, car drivers that frequently face traffic congestion, traded-off several trip-related (including

Design of a new engine mount for vertical and horizontal vibration control using magnetorheological fluid

International Nuclear Information System (INIS)

Phu, D X; Choi, S B; Lee, Y S; Han, M S

2014-01-01

This paper presents a new design of a magnetorheological fluid (MR) mount for vibration control considering both vertical forces and horizontal moments such as are met in various engine systems, including a medium high-speed engine of ship. The newly designed mount, called a MR brake mount, offers several salient benefits such as small size and relatively high load capacity compared with a conventional MR engine mount that can control vertical vibration only. The principal design parameters of the proposed mount are optimally determined to achieve maximum torque with geometric and spatial constraints. Subsequently, the proposed MR mount is designed and manufactured based on the optimized design parameters. It is shown from experimental testing that the proposed mount, which combines MR mount with MR brake, can produce the desired force and torque to reduce unwanted vibration of a medium high-speed engine system of ship subjected to both vertical and horizontal exciting motions. In addition, it is verified that there is no large difference between experiment results and simulation results that are obtained from an analytical model derived in this work. (technical note)

Uncertainty of power curve measurement with a two-beam nacelle-mounted lidar

DEFF Research Database (Denmark)

Wagner, Rozenn; Courtney, Michael Stephen; Friis Pedersen, Troels

2015-01-01

Nacelle lidars are attractive for offshore measurements since they can provide measurements of the free wind speed in front of the turbine rotor without erecting a met mast, which significantly reduces the cost of the measurements. Nacelle-mounted pulsed lidars with two lines of sight (LOS) have...... lies between 1 and 2% for the wind speed range between cut-in and rated wind speed. Finally, the lidar was mounted on the nacelle of a wind turbine in order to perform a power curve measurement. The wind speed was simultaneously measured with a mast-top mounted cup anemometer placed two rotor diameters...... lidar was less than 10% larger on average than that obtained with the mast mounted cup anemometer. Copyright © 2015 John Wiley & Sons, Ltd....

A new approach on seismic mortality estimations based on average population density

Science.gov (United States)

Zhu, Xiaoxin; Sun, Baiqing; Jin, Zhanyong

2016-12-01

This study examines a new methodology to predict the final seismic mortality from earthquakes in China. Most studies established the association between mortality estimation and seismic intensity without considering the population density. In China, however, the data are not always available, especially when it comes to the very urgent relief situation in the disaster. And the population density varies greatly from region to region. This motivates the development of empirical models that use historical death data to provide the path to analyze the death tolls for earthquakes. The present paper employs the average population density to predict the final death tolls in earthquakes using a case-based reasoning model from realistic perspective. To validate the forecasting results, historical data from 18 large-scale earthquakes occurred in China are used to estimate the seismic morality of each case. And a typical earthquake case occurred in the northwest of Sichuan Province is employed to demonstrate the estimation of final death toll. The strength of this paper is that it provides scientific methods with overall forecast errors lower than 20 %, and opens the door for conducting final death forecasts with a qualitative and quantitative approach. Limitations and future research are also analyzed and discussed in the conclusion.

Characterization of Multilayer Piezoelectric Actuators for Use in Active Isolation Mounts

Science.gov (United States)

Wise, Stephanie A.; Hooker, Matthew W.

1997-01-01

Active mounts are desirable for isolating spacecraft science instruments from on-board vibrational sources such as motors and release mechanisms. Such active isolation mounts typically employ multilayer piezoelectric actuators to cancel these vibrational disturbances. The actuators selected for spacecraft systems must consume minimal power while exhibiting displacements of 5 to 10 micron under load. This report describes a study that compares the power consumption, displacement, and load characteristics of four commercially available multilayer piezoelectric actuators. The results of this study indicate that commercially available actuators exist that meet or exceed the design requirements used in spacecraft isolation mounts.

Dynamic evolution of toll-like receptor multigene families in echinoderms

Directory of Open Access Journals (Sweden)

Katherine M Buckley

2012-06-01

Full Text Available The genome of the purple sea urchin, Strongylocentrotus purpuratus, was the first to be sequenced from a long-lived large invertebrate. Analysis of this genome uncovered a surprisingly complex immune system in which the moderately sized sets of pattern recognition receptors that form the core of vertebrate innate immunity are encoded in large multigene families. The sea urchin genome contains 253 Toll-like receptor (TLR genes, more than 200 Nod-like receptors and 1095 scavenger receptor cysteine-rich domains, a ten-fold expansion relative to vertebrates. Given their stereotypic structure and simple intron-exon architecture, the TLRs are the most tractable of these families for more detailed analysis. An immune defense role for these receptors is suggested by their sequence diversity and expression in immunologically active tissues, including phagocytes. This complexity of the sea urchin TLR multigene families largely derives from expansions that are independent of those in vertebrates and protostomes, although a small family of TLRs with structure similar to that of Drosophila Toll likely originated in an ancient eumetazoan ancestor. Several other invertebrate deuterostome genomes have been sequenced, including the cephalochordate, Branchiostoma floridae and the sea urchin Lytechinus variegatus, as well as partial sequences from two other sea urchin species. Here, we present an analysis of the invertebrate deuterostome TLRs with emphasis on the echinoderms. Representatives of most of the S. purpuratus TLR subfamilies and homologs of the protostome-like sequences are found in L. variegatus. The phylogeny of these genes within sea urchins highlights lineage-specific expansions at higher resolution than is evident at the phylum level. These analyses identify quickly evolving TLR subfamilies that are likely to have novel functions and other, more stable, subfamilies that may function similarly to those of vertebrates.

Preparation and mounting of adult Drosophila structures in Canada balsam.

Science.gov (United States)

Stern, David L; Sucena, Elio

2012-03-01

The Drosophila cuticle carries a rich array of morphological details. Thus, cuticle examination has had a central role in the history of genetics. To prepare fine "museum-quality," permanent slides, it is best to mount specimens in Canada Balsam. It is difficult to give precise recipes for Canada Balsam, because every user seems to prefer a slightly different viscosity. Dilute solutions spread easily and do not dry too rapidly while mounting specimens. The disadvantage is that there is actually less Balsam in a "drop" of the solution, and when dried, it can contract from the sides of the coverslip, sometimes disturbing the specimen. Unfortunately, there is no substitute for experience when using Canada Balsam. This protocol describes a procedure for mounting adult cuticles in Canada Balsam.

Mounting Systems for Structural Members, Fastening Assemblies Thereof, and Vibration Isolation Systems Including the Same

Science.gov (United States)

Young, Ken (Inventor); Hindle, Timothy (Inventor); Barber, Tim Daniel (Inventor)

2016-01-01

Mounting systems for structural members, fastening assemblies thereof, and vibration isolation systems including the same are provided. Mounting systems comprise a pair of mounting brackets, each clamped against a fastening assembly forming a mounting assembly. Fastening assemblies comprise a spherical rod end comprising a spherical member having a through opening and an integrally threaded shaft, first and second seating members on opposite sides of the spherical member and each having a through opening that is substantially coaxial with the spherical member through opening, and a partially threaded fastener that threadably engages each mounting bracket forming the mounting assembly. Structural members have axial end portions, each releasably coupled to a mounting bracket by the integrally threaded shaft. Axial end portions are threaded in opposite directions for permitting structural member rotation to adjust a length thereof to a substantially zero strain position. Structural members may be vibration isolator struts in vibration isolation systems.

Scintillation crystal mounting apparatus

International Nuclear Information System (INIS)

Engdahl, L.W.; Deans, A.J.

1982-01-01

An improved detector head for a gamma camera is disclosed. The detector head includes a housing and a detector assembly mounted within the housing. Components of the detector assembly include a crystal sub-assembly, a phototube array, and a light pipe between the phototube array and crystal sub-assembly. The invention provides a unique structure for maintaining the phototubes in optical relationship with the light pipe and preventing the application of forces that would cause the camera's crystal to crack

Let-7i attenuates human brain microvascular endothelial cell damage in oxygen glucose deprivation model by decreasing toll-like receptor 4 expression.

Science.gov (United States)

Xiang, Wei; Tian, Canhui; Peng, Shunli; Zhou, Liang; Pan, Suyue; Deng, Zhen

2017-11-04

The let-7 family of microRNAs (miRNAs) plays an important role on endothelial cell function. However, there have been few studies on their role under ischemic conditions. In this study, we demonstrate that let-7i, belonging to the let-7 family, rescues human brain microvascular endothelial cells (HBMECs) in an oxygen-glucose deprivation (OGD) model. Our data show that the expression of let-7 family miRNAs was downregulated after OGD. Overexpression of let-7i significantly alleviated cell death and improved survival of OGD-treated HBMECs. Let-7i also protected permeability in an in vitro blood brain barrier (BBB) model. Further, let-7i downregulated the expression of toll-like receptor 4 (TLR4), an inflammation trigger. Moreover, overexpression of let-7i decreased matrix metallopeptidase 9 (MMP9) and inducible nitric oxide synthase (iNOS) expression under OGD. Upon silencing TLR4 expression in HBMECs, the anti-inflammatory effect of let-7i was abolished. Our research suggests that let-7i promotes OGD-induced inflammation via downregulating TLR4 expression. Copyright © 2017 Elsevier Inc. All rights reserved.

Light Influences How the Fungal Toxin Deoxynivalenol Affects Plant Cell Death and Defense Responses

Directory of Open Access Journals (Sweden)

Khairul I. Ansari

2014-02-01

Full Text Available The Fusarium mycotoxin deoxynivalenol (DON can cause cell death in wheat (Triticum aestivum, but can also reduce the level of cell death caused by heat shock in Arabidopsis (Arabidopsis thaliana cell cultures. We show that 10 μg mL−1 DON does not cause cell death in Arabidopsis cell cultures, and its ability to retard heat-induced cell death is light dependent. Under dark conditions, it actually promoted heat-induced cell death. Wheat cultivars differ in their ability to resist this toxin, and we investigated if the ability of wheat to mount defense responses was light dependent. We found no evidence that light affected the transcription of defense genes in DON-treated roots of seedlings of two wheat cultivars, namely cultivar CM82036 that is resistant to DON-induced bleaching of spikelet tissue and cultivar Remus that is not. However, DON treatment of roots led to genotype-dependent and light-enhanced defense transcript accumulation in coleoptiles. Wheat transcripts encoding a phenylalanine ammonia lyase (PAL gene (previously associated with Fusarium resistance, non-expressor of pathogenesis-related genes-1 (NPR1 and a class III plant peroxidase (POX were DON-upregulated in coleoptiles of wheat cultivar CM82036 but not of cultivar Remus, and DON-upregulation of these transcripts in cultivar CM82036 was light enhanced. Light and genotype-dependent differences in the DON/DON derivative content of coleoptiles were also observed. These results, coupled with previous findings regarding the effect of DON on plants, show that light either directly or indirectly influences the plant defense responses to DON.

Competing causes of death: a death certificate study

NARCIS (Netherlands)

Mackenbach, J. P.; Kunst, A. E.; Lautenbach, H.; Oei, Y. B.; Bijlsma, F.

1997-01-01

BACKGROUND: Despite the widespread interest in competing causes of death, empirical information on interrelationships between causes of death is scarce. We have used death certificate information to estimate the prevalence of competing causes of death at the moment of dying from specific underlying

Roles of Toll-like receptors in allogeneic islet transplantation.

Science.gov (United States)

Ro, Han; Hong, Juho; Kim, Beom Seok; Lee, Eun Won; Kim, Myung-Gyu; Han, Kyu Hyun; Yeom, Hye-Jung; Lee, Eun Mi; Jeong, Jong Cheol; Oh, Kook-Hwan; Ahn, Curie; Yang, Jaeseok

2012-11-27

Toll-like receptors (TLRs) are involved in the rejection of solid organ allografts. However, the roles of TLRs in islets are still controversial. We investigated the roles of TLRs in donor islets together with those in recipients in allogeneic islet transplantation. To assess the roles of TLRs in either donor islets or recipients, allogeneic islet transplantation was performed using myeloid differentiation factor 88 (MyD88)-knockout (KO), TLR4-KO, or Toll/interleukin-1 receptor domain-containing adaptor-inducing interferon-β (TRIF)-KO mice. Both polyriboinosinic polyribocytidylic acid and lipopolysaccharide (LPS) stimulation induced the mRNA expression of regulated and normal T cell expressed and secreted, interferon-γ-inducible protein-10, monocyte chemotactic protein-1, interleukin-8, and inducible nitric oxide synthase in murine islets, whereas the induction was attenuated in TRIF-KO, interferon-β promoter stimulator-1-KO, and TLR4-KO mice. When islets from MyD88-KO, TLR4-KO, or TRIF-KO C57BL/6 mice were transplanted to BALB/c recipients, graft survival was not better than that of wild-type (WT) islets. However, the survival of the MyD88-KO islet allograft was significantly prolonged when combined with anti-CD40L. In parallel, LPS stimulation in donor islets interfered with anti-CD40L blockade-mediated long-term survival of islet allografts in TLR4-KO recipients. LPS stimulation increased the perigraft infiltration of both T cells and macrophages. Then again, when islets from WT BALB/c mice were transplanted to MyD88-KO, TRIF-KO, or WT C57BL/6 mice, there was no difference in graft survival, although some of the MyD88-KO recipients obtained long-term graft survival. However, anti-CD40L prolonged graft survival significantly in MyD88-KO recipients. The absence of MyD88 in either donors or recipients decreased the perigraft infiltration of inflammatory cells when combined with anti-CD40L. TLRs in both donor islets and recipients are involved in islet allograft

Apparatus and method for mounting photovoltaic power generating systems on buildings

Science.gov (United States)

Russell, Miles Clayton [Lincoln, MA

2008-10-14

Rectangular PV modules (6) are mounted on a building roof (4) by mounting stands that are distributed in rows and columns. Each stand comprises a base plate (10) that rests on the building roof (4) and first and second brackets (12, 14) of different height attached to opposite ends of the base plate (10). Each bracket (12, 14) has dual members for supporting two different PV modules (6), and each PV module (6) has a mounting pin (84) adjacent to each of its four corners. Each module (6) is supported by attachment of two of its mounting pins (84) to different first brackets (12), whereby the modules (6) and their supporting stands are able to resist uplift forces resulting from high velocity winds without the base plates (10) being physically attached to the supporting roof structure (4). Preferably the second brackets (14) have a telescoping construction that permits their effective height to vary from less than to substantially the same as that of the first brackets (12).

77 FR 19010 - Zone J Tolling Co., LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2012-03-29

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1301-000] Zone J Tolling Co., LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Zone J...

Simulation of personalised haemodynamics by various mounting positions of a prosthetic valve using computational fluid dynamics.

Science.gov (United States)

Bongert, Markus; Geller, Marius; Pennekamp, Werner; Nicolas, Volkmar

2018-03-03

Diseases of the cardiovascular system account for nearly 42% of all deaths in the European Union. In Germany, approximately 12,000 patients receive surgical replacement of the aortic valve due to heart valve disease alone each year. A three-dimensional (3D) numerical model based on patient-specific anatomy derived from four-dimensional (4D) magnetic resonance imaging (MRI) data was developed to investigate preoperatively the flow-induced impact of mounting positions of aortic prosthetic valves to select the best orientation for individual patients. Systematic steady-state analysis of blood flow for different rotational mounting positions of the valve is only possible using a virtual patient model. A maximum velocity of 1 m/s was used as an inlet boundary condition, because the opening angle of the valve is at its largest at this velocity. For a comparative serial examination, it is important to define the standardised general requirements to avoid impacts other than the rotated implantation of the prosthetic aortic valve. In this study, a uniform velocity profile at the inlet for the inflow of the aortic valve and the real aortic anatomy were chosen for all simulations. An iterative process, with the weighted parameters flow resistance (1), shear stress (2) and velocity (3), was necessary to determine the best rotated orientation. Blood flow was optimal at a 45° rotation from the standard implantation orientation, which will offer a supply to the coronary arteries.

Adjustable bipod flexures for mounting mirrors in a space telescope.

Science.gov (United States)

Kihm, Hagyong; Yang, Ho-Soon; Moon, Il Kweon; Yeon, Jeong-Heum; Lee, Seung-Hoon; Lee, Yun-Woo

2012-11-10

A new mirror mounting technique applicable to the primary mirror in a space telescope is presented. This mounting technique replaces conventional bipod flexures with flexures having mechanical shims so that adjustments can be made to counter the effects of gravitational distortion of the mirror surface while being tested in the horizontal position. Astigmatic aberration due to the gravitational changes is effectively reduced by adjusting the shim thickness, and the relation between the astigmatism and the shim thickness is investigated. We tested the mirror interferometrically at the center of curvature using a null lens. Then we repeated the test after rotating the mirror about its optical axis by 180° in the horizontal setup, and searched for the minimum system error. With the proposed flexure mount, the gravitational stress at the adhesive coupling between the mirror and the mount is reduced by half that of a conventional bipod flexure for better mechanical safety under launch loads. Analytical results using finite element methods are compared with experimental results from the optical interferometer. Vibration tests verified the mechanical safety and optical stability, and qualified their use in space applications.

Real-time electrocardiogram transmission from Mount Everest during continued ascent.

Directory of Open Access Journals (Sweden)

Wei-Fong Kao

Full Text Available The feasibility of a real-time electrocardiogram (ECG transmission via satellite phone from Mount Everest to determine a climber's suitability for continued ascent was examined. Four Taiwanese climbers were enrolled in the 2009 Mount Everest summit program. Physiological measurements were taken at base camp (5300 m, camp 2 (6400 m, camp 3 (7100 m, and camp 4 (7950 m 1 hour after arrival and following a 10 minute rest period. A total of 3 out of 4 climbers were able to summit Mount Everest successfully. Overall, ECG and global positioning system (GPS coordinates of climbers were transmitted in real-time via satellite phone successfully from base camp, camp 2, camp 3, and camp 4. At each camp, Resting Heart Rate (RHR was transmitted and recorded: base camp (54-113 bpm, camp 2 (94-130 bpm, camp 3 (98-115 bpm, and camp 4 (93-111 bpm. Real-time ECG and GPS coordinate transmission via satellite phone is feasible for climbers on Mount Everest. Real-time RHR data can be used to evaluate a climber's physiological capacity to continue an ascent and to summit.

Motion planning for gantry mounted manipulators

DEFF Research Database (Denmark)

Olsen, Anders Lau; Petersen, Henrik Gordon

2007-01-01

We present a roadmap based planner for finding robot motions for gantry mounted manipulators for a line welding application at Odense Steel Shipyard (OSS). The robot motions are planned subject to constraints on when the gantry may be moved. We show that random sampling of gantry configurations...

Mounting LHCb hadron calorimeter scintillating tiles

CERN Multimedia

Maximilien Brice

2004-01-01

Scintillating tiles are carefully mounted in the hadronic calorimeter for the LHCb detector. These calorimeters measure the energy of particles that interact via the strong force, called hadrons. The detectors are made in a sandwich-like structure where these scintillator tiles are placed between metal sheets.

Anti-tumor Activity of Toll-Like Receptor 7 Agonists

Directory of Open Access Journals (Sweden)

Huju Chi

2017-05-01

Full Text Available Toll-like receptors (TLRs are a class of pattern recognition receptors that play a bridging role in innate immunity and adaptive immunity. The activated TLRs not only induce inflammatory responses, but also elicit the development of antigen specific immunity. TLR7, a member of TLR family, is an intracellular receptor expressed on the membrane of endosomes. TLR7 can be triggered not only by ssRNA during viral infections, but also by immune modifiers that share a similar structure to nucleosides. Its powerful immune stimulatory action can be potentially used in the anti-tumor therapy. This article reviewed the anti-tumor activity and mechanism of TLR7 agonists that are frequently applied in preclinical and clinical investigations, and mainly focused on small synthetic molecules, including imiquimod, resiquimod, gardiquimod, and 852A, etc.

Novel drugs targeting Toll-like receptors for antiviral therapy.

Science.gov (United States)

Patel, Mira C; Shirey, Kari Ann; Pletneva, Lioubov M; Boukhvalova, Marina S; Garzino-Demo, Alfredo; Vogel, Stefanie N; Blanco, Jorge Cg

2014-09-01

Toll-like receptors (TLRs) are sentinel receptors of the host innate immune system that recognize conserved 'pathogen-associated molecular patterns' of invading microbes, including viruses. The activation of TLRs establishes antiviral innate immune responses and coordinates the development of long-lasting adaptive immunity in order to control viral pathogenesis. However, microbe-induced damage to host tissues may release 'danger-associated molecular patterns' that also activate TLRs, leading to an overexuberant inflammatory response and, ultimately, to tissue damage. Thus, TLRs have proven to be promising targets as therapeutics for the treatment of viral infections that result in inflammatory damage or as adjuvants in order to enhance the efficacy of vaccines. Here, we explore recent advances in TLR biology with a focus on novel drugs that target TLRs (agonists and antagonists) for antiviral therapy.

A structural comparison of female-male and female-female mounting in Japanese macaques (Macaca fuscata).

Science.gov (United States)

Ottenheimer Carrier, Lydia; Leca, Jean-Baptiste; Pellis, Sergio; Vasey, Paul L

2015-10-01

In certain populations, female Japanese macaques (Macaca fuscata) mount both males and females. Vasey (2007) proposed that female-female sexual mounting in Japanese macaques may be a neutral evolutionary by-product of a purported adaptation, namely, female-male mounting. In this study, we aim to further examine the proposed link between female-male and female-female mounting in Japanese macaques by comparing the structural characteristics that define both forms of mounting. We do so using Eshkol-Wachman Movement Notation (EWMN), a globographic reference system that can be used to describe the position of body segments. No significant differences were observed in the female mounters' positioning of eight different body segments (i.e., lower torso, mid-torso, upper torso, upper arm, lower arm, upper leg, lower leg, and foot) during female-male and female-female mounting. This finding lends support to the conclusion that female-female and female-male mounting are structurally, and thus, evolutionarily, related. Copyright © 2015 Elsevier B.V. All rights reserved.

Vibration control of a camera mount system for an unmanned aerial vehicle using piezostack actuators

International Nuclear Information System (INIS)

Oh, Jong-Seok; Choi, Seung-Bok; Han, Young-Min

2011-01-01

This work proposes an active mount for the camera systems of unmanned aerial vehicles (UAV) in order to control unwanted vibrations. An active actuator of the proposed mount is devised as an inertial type, in which a piezostack actuator is directly connected to the inertial mass. After evaluating the actuating force of the actuator, it is combined with the rubber element of the mount, whose natural frequency is determined based on the measured vibration characteristics of UAV. Based on the governing equations of motion of the active camera mount, a robust sliding mode controller (SMC) is then formulated with consideration of parameter uncertainties and hysteresis behavior of the actuator. Subsequently, vibration control performances of the proposed active mount are experimentally evaluated in the time and frequency domains. In addition, a full camera mount system of UAVs that is supported by four active mounts is considered and its vibration control performance is evaluated in the frequency domain using a hardware-in-the-loop simulation (HILS) method

Inducible cardiac ischaemia is related to a decrease in the whole-blood Toll-like receptor 2 and 4 response

NARCIS (Netherlands)

Elsenberg, Ellen H. A. M.; Versteeg, Dik; Sels, Jan-Willem; Vlaar, Pieter-Jan J.; Hobbelink, Monique G. G.; Cramer, Maarten-Jan M.; de Kleijn, Dominique P. V.; Tio, Rene A.; de Smet, Bart J. G. L.; Doevendans, Pieter A.; Hoefer, Imo E.; Pasterkamp, Gerard

TLR (Toll-like receptor) activation-induced inflammatory responses are important in the progression of atherosclerosis. We previously showed that TLR-dependent leucocyte responsiveness is acutely attenuated following percutaneous coronary intervention or vascular surgery. Furthermore, cytokine

Arterial blood gases and oxygen content in climbers on Mount Everest

NARCIS (Netherlands)

Grocott, Michael P. W.; Martin, Daniel S.; Levett, Denny Z. H.; McMorrow, Roger; Windsor, Jeremy; Montgomery, Hugh E.; Ahuja, V.; Aref-Adib, G.; Burnham, R.; Chisholm, A.; Clarke, K.; Coates, D.; Coates, M.; Cook, D.; Cox, M.; Dhillon, S.; Dougall, C.; Doyle, P.; Duncan, P.; Edsell, M.; Edwards, L.; Evans, L.; Gardiner, P.; Grocott, M.; Gunning, P.; Hart, N.; Harrington, J.; Harvey, J.; Holloway, C.; Howard, D.; Hurlbut, D.; Imray, C.; Ince, C.; Jonas, M.; van der Kaaij, J.; Khosravi, M.; Kolfschoten, N.; Levett, D.; Luery, H.; Luks, A.; Martin, D.; McMorrow, R.; Meale, P.; Mitchell, K.; Montgomery, H.; Morgan, G.; Morgan, J.; Murray, A.; Mythen, M.; Newman, S.

2009-01-01

BACKGROUND: The level of environmental hypobaric hypoxia that affects climbers at the summit of Mount Everest (8848 m [29,029 ft]) is close to the limit of tolerance by humans. We performed direct field measurements of arterial blood gases in climbers breathing ambient air on Mount Everest. METHODS:

Mounting ground sections of teeth: Cyanoacrylate adhesive versus Canada balsam.

Science.gov (United States)

Vangala, Manogna Rl; Rudraraju, Amrutha; Subramanyam, R V

2016-01-01

Hard tissues can be studied by either decalcification or by preparing ground sections. Various mounting media have been tried and used for ground sections of teeth. However, there are very few studies on the use of cyanoacrylate adhesive as a mounting medium. The aim of our study was to evaluate the efficacy of cyanoacrylate adhesive (Fevikwik™) as a mounting medium for ground sections of teeth and to compare these ground sections with those mounted with Canada balsam. Ground sections were prepared from twenty extracted teeth. Each section was divided into two halves and mounted on one slide, one with cyanoacrylate adhesive (Fevikwik™) and the other with Canada balsam. Scoring for various features in the ground sections was done by two independent observers. Statistical analysis using Student's t-test (unpaired) of average scores was performed for each feature observed. No statistically significant difference was found between the two for most of the features. However, cyanoacrylate was found to be better than Canada balsam for observing striae of Retzius (P < 0.0205), enamel lamellae (P < 0.036), dentinal tubules (P < 0.0057), interglobular dentin (P < 0.0001), sclerotic dentin - transmitted light (P < 0.00001), sclerotic dentin - polarized light (P < 0.0002) and Sharpey's fibers (P < 0.0004). This initial study shows that cyanoacrylate is better than Canada balsam for observing certain features of ground sections of teeth. However, it remains to be seen whether it will be useful for studying undecalcified sections of carious teeth and for soft tissue sections.

Tyrosine Phosphorylation in Toll-Like Receptor Signaling

Science.gov (United States)

Chattopadhyay, Saurabh; Sen, Ganes C.

2014-01-01

There is a wealth of knowledge about how different Ser/Thr protein kinases participate in Toll-like receptor (TLR) signaling. In many cases, we know the identities of the Ser/Thr residues of various components of the TLR-signaling pathways that are phosphorylated, the functional consequences of the phosphorylation and the responsible protein kinases. In contrast, the analysis of Tyr-phosphorylation of TLRs and their signaling proteins is currently incomplete, because several existing analyses are not systematic or they do not rely on robust experimental data. Nevertheless, it is clear that many TLRs require, for signaling, ligand-dependent phosphorylation of specific Tyr residues in their cytoplasmic domains; the list includes TLR2, TLR3, TLR4, TLR5, TLR8 and TLR9. In this article, we discuss the current status of knowledge on the effect of Tyr-phosphorylation of TLRs and their signaling proteins on their biochemical and biological functions, the possible identities of the relevant protein tyrosine kinases (PTKs) and the nature of regulations of PTK-mediated activation of TLR signaling pathways. PMID:25022196

Tracing shadows: How gendered power relations shape the impacts of maternal death on living children in sub Saharan Africa.

Science.gov (United States)

Yamin, Alicia Ely; Bazile, Junior; Knight, Lucia; Molla, Mitike; Maistrellis, Emily; Leaning, Jennifer

2015-06-01

Driven by the need to better understand the full and intergenerational toll of maternal mortality (MM), a mixed-methods study was conducted in four countries in sub-Saharan Africa to investigate the impacts of maternal death on families and children. The present analysis identifies gender as a fundamental driver not only of maternal, but also child health, through manifestations of gender inequity in household decision making, labor and caregiving, and social norms dictating the status of women. Focus group discussions were conducted with community members, and in depth qualitative interviews with key-informants and stakeholders, in Tanzania, Ethiopia, Malawi, and South Africa between April 2012 and October 2013. Findings highlight that socially constructed gender roles, which define mothers as caregivers and fathers as wage earners, and which limit women's agency regarding childcare decisions, among other things, create considerable gaps when it comes to meeting child nutrition, education, and health care needs following a maternal death. Additionally, our findings show that maternal deaths have differential effects on boy and girl children, and exacerbate specific risks for girl children, including early marriage, early pregnancy, and school drop-out. To combat both MM, and to mitigate impacts on children, investment in health services interventions should be complemented by broader interventions regarding social protection, as well as aimed at shifting social norms and opportunity structures regarding gendered divisions of labor and power at household, community, and society levels. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

CFRP platform and hexapod mount for the Array of MIcrowave Background Anisotropy (AMiBA)

Science.gov (United States)

Raffin, Philippe A.; Martin, Robert N.; Huang, Yau-De; Patt, Ferdinand; Romeo, Robert C.; Chen, Ming-Tang; Kingsley, Jeffrey S.

2004-09-01

AMiBA consists of a 90 GHz interferometric array telescope with dishes ranging in size from 0.3 to 2.4 meter in diameter, mounted on a 6-meter fully steerable platform. The dishes are attached to the receivers, which are mounted on a platform controlled by a six degree of freedom hexapod mount. The hexapod mount is a parallel connection manipulator also called Stewart Platform. The basic reference for this mechanism is a paper by Stewart. The Stewart Platform is a unique kinematically constrained work platform. It can be manipulated through the six degrees of freedom. The hexapod also provides better accuracy, rigidity, load to weight ratio and load distribution than a serial manipulator or traditional manipulator. The advantages of the hexapod shows that it is a great choice for the AMiBA project. Vertex Antennentechnik GmbH fabricates the hexapod. Testing has started in Germany. The telescope will be delivered in the summer of 2004. The 6m in diameter hexagonal platform is made of carbon fiber reinforced plastics (CFRP) and consists of seven pieces of three different unique types. The platform can be disassembled and fits in a container for transportation. The mounting plane flatness is an important issue for the platform assembly. The deflection angle of the mounting plane relative to any other mounting position must be less than 20 arcsec. Meanwhile, the platform must endure a loading of 3 tons. The platform has been built by Composite Mirror Applications, Inc. (CMA) in Tucson, and mounted on the Hexapod in Germany. This report describes the design and testing of platform and mount for the AMiBA telescope.

[Association of polymorphisms in toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan].

Science.gov (United States)

Gimalova, G F; Karunas, A S; Fedorova, Iu Iu; Gumennaia, É R; Levasheva, S V; Khismatullina, Z R; Prans, E; Koks, S; Étkina, É I; Khusnutdinova, É K

2014-01-01

Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease developing as a result of the interaction between genetic predisposition and environmental factors. Considerable role in allergic diseases development is played by polymorphisms of genes of pattern-recognition receptors (PRR) which are capable of recognizing conservative standard molecular structures (patterns) unique for large pathogen groups. In this study polymorphic variants of PRR genes--Toll-like receptors (TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, TLR10), NOD-like receptors (NOD1, NOD2), lipopolysaccharide receptor CD14 gene, and C11orf30 and LRRC32 genes, located in 11q13.5 region, have been investigated in AD patients and control subjects from the Republic of Bashkortostan. An association of TLR1 (rs5743571 and rs5743604), TLR6 (rs5743794) and TLR10 (rs11466617) with AD was found. Our results confirm an important role of the innate immune system in the pathogenesis of AD and the significance of polymorphisms within the Toll-like receptor 2 subfamily genes in AD development.

Bovine lactoferrin counteracts Toll-like receptor mediated activation signals in antigen presenting cells.

Directory of Open Access Journals (Sweden)

Patrizia Puddu

Full Text Available Lactoferrin (LF, a key element in mammalian immune system, plays pivotal roles in host defence against infection and excessive inflammation. Its protective effects range from direct antimicrobial activities against a large panel of microbes, including bacteria, viruses, fungi and parasites, to antinflammatory and anticancer activities. In this study, we show that monocyte-derived dendritic cells (MD-DCs generated in the presence of bovine LF (bLF fail to undergo activation by up-modulating CD83, co-stimulatory and major histocompatibility complex molecules, and cytokine/chemokine secretion. Moreover, these cells are weak activators of T cell proliferation and retain antigen uptake activity. Consistent with an impaired maturation, bLF-MD-DC primed T lymphocytes exhibit a functional unresponsiveness characterized by reduced expression of CD154 and impaired expression of IFN-γ and IL-2. The observed imunosuppressive effects correlate with an increased expression of molecules with negative regulatory functions (i.e. immunoglobulin-like transcript 3 and programmed death ligand 1, indoleamine 2,3-dioxygenase, and suppressor of cytokine signaling-3. Interestingly, bLF-MD-DCs produce IL-6 and exhibit constitutive signal transducer and activator of transcription 3 activation. Conversely, bLF exposure of already differentiated MD-DCs completely fails to induce IL-6, and partially inhibits Toll-like receptor (TLR agonist-induced activation. Cell-specific differences in bLF internalization likely account for the distinct response elicited by bLF in monocytes versus immature DCs, providing a mechanistic base for its multiple effects. These results indicate that bLF exerts a potent anti-inflammatory activity by skewing monocyte differentiation into DCs with impaired capacity to undergo activation and to promote Th1 responses. Overall, these bLF-mediated effects may represent a strategy to block excessive DC activation upon TLR-induced inflammation, adding

Field-trip guide to Mount Hood, Oregon, highlighting eruptive history and hazards

Science.gov (United States)

Scott, William E.; Gardner, Cynthia A.

2017-06-22

This guidebook describes stops of interest for a geological field trip around Mount Hood volcano. It was developed for the 2017 International Association of Volcanology and Chemistry of the Earth’s Interior (IAVCEI) Scientific Assembly in Portland, Oregon. The intent of this guidebook and accompanying contributions is to provide an overview of Mount Hood, including its chief geologic processes, magmatic system, eruptive history, local tectonics, and hazards, by visiting a variety of readily accessible localities. We also describe coeval, largely monogenetic, volcanoes in the region. Accompanying the field-trip guidebook are separately authored contributions that discuss in detail the Mount Hood magmatic system and its products and behavior (Kent and Koleszar, this volume); Mount Hood earthquakes and their relation to regional tectonics and the volcanic system (Thelen and Moran, this volume); and young surface faults cutting the broader Mount Hood area whose extent has come to light after acquisition of regional light detection and ranging coverage (Madin and others, this volume).The trip makes an approximately 175-mile (280-kilometer) clockwise loop around Mount Hood, starting and ending in Portland. The route heads east on Interstate 84 through the Columbia River Gorge National Scenic Area. The guidebook points out only a few conspicuous features of note in the gorge, but many other guides to the gorge are available. The route continues south on the Mount Hood National Scenic Byway on Oregon Route 35 following Hood River, and returns to Portland on U.S. Highway 26 following Sandy River. The route traverses rocks as old as the early Miocene Eagle Creek Formation and overlying Columbia River Basalt Group of middle Miocene age, but chiefly lava flows and clastic products of arc volcanism of late Miocene to Holocene age.

Using Priors to Compensate Geometrical Problems in Head-Mounted Eye Trackers

DEFF Research Database (Denmark)

Batista Narcizo, Fabricio; Ahmed, Zaheer; Hansen, Dan Witzner

The use of additional information (a.k.a. priors) to help the eye tracking process is presented as an alternative to compensate classical geometrical problems in head-mounted eye trackers. Priors can be obtained from several distinct sources, such as: sensors to collect information related...... estimation specially for uncalibrated head-mounted setups....

An improved mounting device for attaching intracranial probes in large animal models.

Science.gov (United States)

Dunster, Kimble R

2015-12-01

The rigid support of intracranial probes can be difficult when using animal models, as mounting devices suitable for the probes are either not available, or designed for human use and not suitable in animal skulls. A cheap and reliable mounting device for securing intracranial probes in large animal models is described. Using commonly available clinical consumables, a universal mounting device for securing intracranial probes to the skull of large animals was developed and tested. A simply made mounting device to hold a variety of probes from 500 μm to 1.3 mm in diameter to the skull was developed. The device was used to hold probes to the skulls of sheep for up to 18 h. No adhesives or cements were used. The described device provides a reliable method of securing probes to the skull of animals.

A new magnetorheological mount featured by changeable damping gaps using a moved-plate valve structure

International Nuclear Information System (INIS)

Phu, Do Xuan; Shah, Kruti; Choi, Seung-Bok

2014-01-01

In this work, a new type of a magnetorheological (MR) fluid mount is proposed and its performances are experimentally investigated. The design of this MR mount is based on two operating modes of MR fluid: flow mode and shear mode. These modes are applied to the mechanism design consisting of two components: a fixed plate for applying the flow mode, and a moved plate for applying the shear mode of MR fluid motion. These plates belong to the valve-type structure of MR mount. The primary objective using the moved plate is to overcome the block-up phenomenon which frequently occurs in the conventional-type MR mount, in which there is no flow of MR fluid through the damping gap. In this research, a laboratorial fluid (MRF140) is used in the design and optimization of MR mount. This fluid features plate-like particles unlike the sphere particles. The yield stress of the fluid is measured as a function of the magnetic field and the theoretical analysis for the mount design is undertaken using the properties of the MR fluid, followed by design optimization. The objective function is concentrated on maximal damping force of the MR mount subjected to parameter constraints. Based on the results of optimization, the proposed MR mount is manufactured and tested for the performance evaluation. Vibration control capability and block-up phenomenon are investigated and compared between the proposed and conventional MR mounts. (paper)

Near-toll quality digital speech transmission in the mobile satellite service

Science.gov (United States)

Townes, S. A.; Divsalar, D.

1986-01-01

This paper discusses system considerations for near-toll quality digital speech transmission in a 5 kHz mobile satellite system channel. Tradeoffs are shown for power performance versus delay for a 4800 bps speech compression system in conjunction with a 16 state rate 2/3 trellis coded 8PSK modulation system. The suggested system has an additional 150 ms of delay beyond the propagation delay and requires an E(b)/N(0) of about 7 dB for a Ricean channel assumption with line-of-sight to diffuse component ratio of 10 assuming ideal synchronization. An additional loss of 2 to 3 dB is expected for synchronization in fading environment.

Function and mechanism of toll-like receptors in cerebral ischemic tolerance: from preconditioning to treatment

OpenAIRE

Wang, Peng-Fei; Xiong, Xiao-Yi; Chen, Jing; Wang, Yan-Chun; Duan, Wei; Yang, Qing-Wu

2015-01-01

Increasing evidence suggests that toll-like receptors (TLRs) play an important role in cerebral ischemia-reperfusion injury. The endogenous ligands released from ischemic neurons activate the TLR signaling pathway, resulting in the production of a large number of inflammatory cytokines, thereby causing secondary inflammation damage following cerebral ischemia. However, the preconditioning for minor cerebral ischemia or the preconditioning with TLR ligands can reduce cerebral ischemic injury b...

Advanced astigmatism-corrected tandem Wadsworth mounting for small-scale spectral broadband imaging spectrometer.

Science.gov (United States)

Lei, Yu; Lin, Guan-yu

2013-01-01

Tandem gratings of double-dispersion mount make it possible to design an imaging spectrometer for the weak light observation with high spatial resolution, high spectral resolution, and high optical transmission efficiency. The traditional tandem Wadsworth mounting is originally designed to match the coaxial telescope and large-scale imaging spectrometer. When it is used to connect the off-axis telescope such as off-axis parabolic mirror, it presents lower imaging quality than to connect the coaxial telescope. It may also introduce interference among the detector and the optical elements as it is applied to the short focal length and small-scale spectrometer in a close volume by satellite. An advanced tandem Wadsworth mounting has been investigated to deal with the situation. The Wadsworth astigmatism-corrected mounting condition for which is expressed as the distance between the second concave grating and the imaging plane is calculated. Then the optimum arrangement for the first plane grating and the second concave grating, which make the anterior Wadsworth condition fulfilling each wavelength, is analyzed by the geometric and first order differential calculation. These two arrangements comprise the advanced Wadsworth mounting condition. The spectral resolution has also been calculated by these conditions. An example designed by the optimum theory proves that the advanced tandem Wadsworth mounting performs excellently in spectral broadband.

The alignment and isostatic mount bonding technique of the aerospace Cassegrain telescope primary mirror

Science.gov (United States)

Lin, Wei Cheng; Chang, Shenq-Tsong; Lin, Yu-Chuan; Hsu, Ming-Ying; Chang, Yu-Ting; Chang, Sheng-Hsiung; Huang, Ting-Ming

2012-10-01

In order to meet both optical performance and structural stiffness requirements of the aerospace Cassegrain telescope, iso-static mount is used as the interface between the primary mirror and the main plate. This article describes the alignment and iso-static mount bonding technique of the primary mirror by assistance of CMM. The design and assembly of mechanical ground support equipment (MGSE) which reduces the deformation of primary mirror by the gravity effect is also presented. The primary mirror adjusting MGSE consists of X-Y linear translation stages, rotation stage and kinematic constrain platform which provides the function of decenter, orientation, tilt and height adjustment of the posture sequentially. After CMM measurement, the radius of curvature, conic constant, decenter and tilt, etc. will be calculated. According to these results, the posture of the mirror will be adjusted to reduce the tilt by the designed MGSE within 0.02 degrees and the distance deviation from the best fitted profile of mirror to main plate shall be less than 0.01 mm. After that, EC 2216 adhesive is used to bond mirror and iso-static mount. During iso-static mount bonding process, CMM is selected to monitor the relative position deviation of the iso-static mount until the adhesive completely cured. After that, the wave front sensors and strain gauges are used to monitor the strain variation while the iso-static mount mounted in the main plate with the screws by the torque wrench. This step is to prevent deformation of the mirror caused from force of the iso-static mount during the mounting process. In the end, the interferometer is used for the optical performance test with +1G and -1G to check the alignment and bonding technique is well or not.

Taking a Toll（Toll-free holidays bring massive congestion and opposition by highway operators By Zhou Xiaoyan）

Institute of Scientific and Technical Information of China (English)

无

2012-01-01

Dubbed the ＂＇Golden Week,＂ the National Day holiday （normally October 1-7） is a traditional peak travel period for many Chinese who hit the road. But this year＇s holiday was different from years past： most motorists across the country were exempt from paying toll fees.

Self-tuning disturbance feedforward control with drift prevention for air mount systems

NARCIS (Netherlands)

Beijen, M.A.; Heertjes, M.F.; Butler, H.

2015-01-01

A MIMO disturbance feedforward control strategy is presented to isolate an industrial active vibration isolation system with air mounts from broadband floor vibrations. The feedforward controller compensates for the static damping and stiffness of the air mount suspension, leading to significant

Renal expression of Toll-like receptor 2 and 4 : Dynamics in human allograft injury and comparison to rodents

NARCIS (Netherlands)

Stribos, Elisabeth G. D.; van Werkhoven, Maaike B.; Poppelaars, Felix; van Goor, Harry; Olinga, Peter; van Son, Willem J.; Damman, Jeffrey; Seelen, Marcus

Activation of the innate immunity through Toll-like receptors (TLRs) has been postulated to play an important role in the pathophysiology of renal allograft dysfunction. TLR2 and TLR4 dynamics in different human post-transplant pathological entities has never been studied. Therefore, we evaluated

Renal expression of Toll-like receptor 2 and 4: dynamics in human allograft injury and comparison to rodents

NARCIS (Netherlands)

Stribos, Elisabeth G. D.; van Werkhoven, Maaike B.; Poppelaars, Felix; van Goor, Harry; Olinga, Peter; van Son, Willem J.; Damman, Jeffrey; Seelen, Marc A.

2015-01-01

Activation of the innate immunity through Toll-like receptors (TLRs) has been postulated to play an important role in the pathophysiology of renal allograft dysfunction. TLR2 and TLR4 dynamics in different human post-transplant pathological entities has never been studied. Therefore, we evaluated

The role of MAPK in CD4+ T cells toll-like receptor 9-mediated signaling following HHV-6 infection

International Nuclear Information System (INIS)

Chi, Jing; Wang, Fang; Li, Lingyun; Feng, Dongju; Qin, Jian; Xie, Fangyi; Zhou, Feng; Chen, Yun; Wang, Jinfeng; Yao, Kun

2012-01-01

Human herpesvirus-6 (HHV-6) is an important immunosuppressive and immunomodulatory virus that primarily infects immune cells (mainly CD4 + T cells) and strongly suppresses the proliferation of infected cells. Toll-like receptors are pattern-recognition receptors essential for the development of an appropriate innate immune defense against infection. To understand the role of CD4 + T cells in the innate response to HHV-6 infection and the involvement of TLRs, we used an in vitro infection model and observed that the infection of CD4 + T cells resulted in the activation of JNK/SAPK via up-regulation of toll-like receptor 9 (TLR9). Associated with JNK activation, annexin V-PI staining indicated that HHV-6A was a strong inducer of apoptosis. Apoptotic response associated cytokines, IL-6 and TNF-α also induced by HHV-6A infection.

Microglia are required for astroglial toll-like receptor 4 response and for optimal TLR2 and TLR3 response

DEFF Research Database (Denmark)

Holm, Thomas H; Draeby, Dina; Owens, Trevor

2012-01-01

Within the central nervous system, astrocytes and microglia are the primary responders to endogenous ligands released upon injury and stress, as well as to infectious pathogens. Toll-like receptors (TLRs) are implicated in recognition of both types of stimulus. Whether astrocytes respond as stron......Within the central nervous system, astrocytes and microglia are the primary responders to endogenous ligands released upon injury and stress, as well as to infectious pathogens. Toll-like receptors (TLRs) are implicated in recognition of both types of stimulus. Whether astrocytes respond...... astrocytes from mixed glial cultures and measured their response to TLR agonists. Our results show that the response of astrocytes to TLR2 and TLR3 agonists is greatly enhanced by, and response to TLR4 agonists is completely dependent on, the presence of functional microglia. In the case of the TLR4 response...

Deliberating death.

Science.gov (United States)

Landes, Scott D

2010-01-01

Utilizing a particular case study of a woman attempting to come to terms with her death, this article explores the difficult metaphors of death present within the Christian tradition. Tracing a Christian understanding of death back to the work of Augustine, the case study is utilized to highlight the difficulties presented by past and present theology embracing ideas of punishment within death. Following the trajectory of the case study, alternative understandings of death present in recent Christian theology and within Native American spirituality are presented in an attempt to find room for a fuller meaning of death post-reconciliation, but premortem.

Flush-mounting technique for composite beams

Science.gov (United States)

Harman, T. C.; Kay, B. F.

1980-01-01

Procedure permits mounting of heavy parts to surface of composite beams without appreciably weakening beam web. Web is split and held apart in region where attachment is to be made by lightweight precast foam filler. Bolt hole penetrates foam rather than web, and is secured by barrelnut in transverse bushing through web.

Making sense of Mount St. Helens

Science.gov (United States)

Steve Nash

2010-01-01

The eruption of Mount St. Helens in 1980 resulted in "a grand experiment that you could never have gotten anybody to fund," says Forest Service ecologist Charles Crisafulli. "Everything's new. It's a new landform." Unlike most misbehaving volcanoes, this one provided an accessible laboratory right along the Interstate-5 corridor, with the...

May 1980 Mount Saint Helens, USA Images

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — An earthquake occurred at 15 32 UT, only seconds before the explosion that began the eruption of Mount St. Helens volcano. This eruption and blast blew off the top...

Measurement & Minimization of Mount Induced Strain on Double Crystal Monochromator Crystals

Science.gov (United States)

Kelly, J.; Alcock, S. G.

2013-03-01

Opto-mechanical mounts can cause significant distortions to monochromator crystals and mirrors if not designed or implemented carefully. A slope measuring profiler, the Diamond-NOM [1], was used to measure the change in tangential slope as a function of crystal clamping configuration and load. A three point mount was found to exhibit the lowest surface distortion (Diamond Light Source.

Aerodynamic Optimization of an Over-the-Wing-Nacelle-Mount Configuration

OpenAIRE

Sasaki, Daisuke; Nakahashi, Kazuhiro

2011-01-01

An over-the-wing-nacelle-mount airplane configuration is known to prevent the noise propagation from jet engines toward ground. However, the configuration is assumed to have low aerodynamic efficiency due to the aerodynamic interference effect between a wing and a nacelle. In this paper, aerodynamic design optimization is conducted to improve aerodynamic efficiency to be equivalent to conventional under-the-wing-nacelle-mount configuration. The nacelle and wing geometry are modified to achiev...

Managing change : natural gas transportation to the eastern toll zone

International Nuclear Information System (INIS)

Valiante, U.

2001-01-01

The Cogenerators Alliance includes Ontario's largest end-use natural gas consumers, Tractebel Power, Westcoast Power, Lake Superior Power, TransAlta Energy, Cardinal Power of Canada and Whitby Cogeneration. Together, they represent 157,798 GJ/day contracted volume. This paper focused on the changing face of the natural gas industry in North America with closer economic ties between Canada, the United States and Mexico in a competitive energy market. The role of Alliance Pipeline in transporting natural gas to markets and the implication of regulation and toll increases were also discussed. It was noted that there is a need for regulatory changes to provide existing pipelines with the appropriate tools needed to ensure the competitive environment will function effectively. tabs., figs

Cannabinoids and Innate Immunity: Taking a Toll on Neuroinflammation

Directory of Open Access Journals (Sweden)

Eric J. Downer

2011-01-01

Full Text Available The biologically active components of cannabis have therapeutic potential in neuroinflammatory disorders due to their anti-inflammatory propensity. Cannabinoids influence immune function in both the peripheral and the central nervous system (CNS, and the components of the cannabinoid system, the cannabinoid receptors and their endogenous ligands (endocannabinoids, have been detected on immune cells as well as in brain glia. Neuroinflammation is the complex innate immune response of neural tissue to control infection and eliminate pathogens, and Toll-like receptors (TLRs, a major family of pattern recognition receptors (PRRs that mediate innate immunity, have emerged as players in the neuroinflammatory processes underpinning various CNS diseases. This review will highlight evidence that cannabinoids interact with the immune system by impacting TLR-mediated signaling events, which may provide cues for devising novel therapeutic approaches for cannabinoid ligands.

Tilt signals at Mount Melbourne, Antarctica: evidence of a shallow volcanic source

Directory of Open Access Journals (Sweden)

Salvatore Gambino

2016-06-01

Full Text Available Mount Melbourne (74°21′ S, 164°43′ E is a quiescent volcano located in northern Victoria Land, Antarctica. Tilt signals have been recorded on Mount Melbourne since early 1989 by a permanent shallow borehole tiltmeter network comprising five stations. An overall picture of tilt, air and permafrost temperatures over 15 years of continuous recording data is reported. We focused our observations on long-term tilt trends that at the end of 1997 showed coherent changes at the three highest altitude stations, suggesting the presence of a ground deformation source whose effects are restricted to the summit area of Mount Melbourne. We inverted these data using a finite spherical body source, thereby obtaining a shallow deflation volume source located under the summit area. The ground deformation observed corroborates the hypothesis that the volcanic edifice of Mount Melbourne is active and should be monitored multidisciplinarily.

Increased earthquake safety through optimised mounting concept

International Nuclear Information System (INIS)

Kollmann, Dieter; Senechal, Holger

2013-01-01

Since Fukushima, there has been intensive work on earthquake safety in all nuclear power plants. A large part of these efforts aim at the earthquake safety of safety-relevant pipeline systems. The problem with earthquake safety here is not the pipeline system itself but rather its mountings and connections to components. This is precisely the topic that the KAE dealt with in years of research and development work. It has developed an algorithm that determines the optimal mounting concept with a few iteration steps depending on arbitrary combinations of loading conditions whilst maintaining compliance with relevant regulations for any pipeline systems. With this tool at hand, we are now in a position to plan and realise remedial measures accurately with minimum time and hardware expenditure, and so distinctly improve the earthquake safety of safety-relevant systems. (orig.)

Preparation of source mounts for 4π counting

International Nuclear Information System (INIS)

Johnson, E.P.

1991-01-01

The 4πβ/γ counter in the ANSTO radioisotope standards laboratory at Lucas Heights constitutes part of the Australian national standard for radioactivity. Sources to be measured in the counter must be mounted on a substrate which is strong enough to withstand careful handling and transport. The substrate must also be electrically conducting to minimise counting errors caused by charging of the source, and it must have very low superficial density so that little or none of the radiation is absorbed. The entire process of fabrication of VYNS films, coating them with gold/palladium and transferring them to source mount rings, as carried out in the radioisotope standards laboratory, is documented. 3 refs., 2 tabs., 6 figs

Toll-Like Receptor-2 Mediates Diet and/or Pathogen Associated Atherosclerosis: Proteomic Findings

OpenAIRE

Madan, Monika; Amar, Salomon

2008-01-01

Accumulating evidence implicates a fundamental link between the immune system and atherosclerosis. Toll-like receptors are principal sensors of the innate immune system. Here we report an assessment of the role of the TLR2 pathway in atherosclerosis associated with a high-fat diet and/or bacteria in ApoE(+/-) mice.To explore the role of TLR2 in inflammation- and infection-associated atherosclerosis, 10 week-old ApoE(+/-)-TLR2(+/+), ApoE(+/-)-TLR2(+/-) and ApoE(+/-)-TLR2(-/-) mice were fed eit...

New Az/El mount for Haystack Observatory's Small Radio Telescope kit

Science.gov (United States)

Cobb, M. L.

2005-12-01

The Small Radio Telescope (SRT) kit was designed by Haystack Observatory as part of their educational outreach effort. The SRT uses a custom designed FFT based radio spectrometer receiver with a controller to position a 2.3m dish to make various radio astronomy observations including the 21 cm spin flip line of atomic hydrogen. Because there is no sizable commercial market for a two dimensional mount for dishes of this size, finding an appropriate provider as been a recurring problem for the project. Originally, the kit used a modified motor mount from Kaultronics called the H180. Two of these motors were combined by a specially designed adaptor to allow motion in azimuth and elevation. When Kaultronics was bought out by California Amplifier they discontinued production of the H180. The next iteration used a compact unit called the alfa-spid which was made in Germany and imported through Canada. The alfa-spid was designed to point various ham radio antennas and proved problematic with 2.3m dishes. Most recently the CASSI (Custom Astronomical Support Services, Inc.) corporation has designed and certified a robust Az/El mount capable of supporting dishes up to 12 feet (3.6m) with 100 MPH wind loads. This paper presents the design and operating characteristics of the new CASSI mount. The CASSI mount is now shipped with the SRT kit and should serve the project well for the foreseeable future.

GNSS Signal Tracking Performance Improvement for Highly Dynamic Receivers by Gyroscopic Mounting Crystal Oscillator.

Science.gov (United States)

Abedi, Maryam; Jin, Tian; Sun, Kewen

2015-08-31

In this paper, the efficiency of the gyroscopic mounting method is studied for a highly dynamic GNSS receiver's reference oscillator for reducing signal loss. Analyses are performed separately in two phases, atmospheric and upper atmospheric flights. Results show that the proposed mounting reduces signal loss, especially in parts of the trajectory where its probability is the highest. This reduction effect appears especially for crystal oscillators with a low elevation angle g-sensitivity vector. The gyroscopic mounting influences frequency deviation or jitter caused by dynamic loads on replica carrier and affects the frequency locked loop (FLL) as the dominant tracking loop in highly dynamic GNSS receivers. In terms of steady-state load, the proposed mounting mostly reduces the frequency deviation below the one-sigma threshold of FLL (1σ(FLL)). The mounting method can also reduce the frequency jitter caused by sinusoidal vibrations and reduces the probability of signal loss in parts of the trajectory where the other error sources accompany this vibration load. In the case of random vibration, which is the main disturbance source of FLL, gyroscopic mounting is even able to suppress the disturbances greater than the three-sigma threshold of FLL (3σ(FLL)). In this way, signal tracking performance can be improved by the gyroscopic mounting method for highly dynamic GNSS receivers.

Design and functional tests of the Euclid grism mount

Science.gov (United States)

Rossin, Ch.; Grange, R.; Caillat, A.; Costille, A.; Sanchez, P.; Ceria, W.

2017-11-01

The Euclid mission selected by ESA in the Cosmic Vision program is dedicated to understand dark energy and dark matter. One of the probes based on detection of Baryonic Acoustic Oscillations required the redshift of millions of galaxies. This massive spectroscopic survey relies on the Near Infrared SpectroPhotometer (NISP) using grism in slitless mode. In this Euclid NISP context, we designed a cryogenic mount for the four grisms of the spectroscopic channel. This mount has to maintain optical performances and alignment at the cryogenic temperature of 120K and to survive launch vibrations. Due to a very small mass and volume budget allowed in the Grism Wheel Assembly our design relies on a weight relief Invar ring glued to the grism by tangential flexures. Tangential flexures have the advantage of small height but the drawback of less decoupling capabilities than bipods. We will present the design of the mount and the integration and functional tests to stay within the 60 nm RMS transmitted wavefront error budget allowed to the grism.

Geologic Map of Mount Mazama and Crater Lake Caldera, Oregon

Science.gov (United States)

Bacon, Charles R.

2008-01-01

Crater Lake partly fills one of the most spectacular calderas of the world, an 8-by-10-km basin more than 1 km deep formed by collapse of the volcano known as Mount Mazama (fig. 1) during a rapid series of explosive eruptions about 7,700 years ago. Having a maximum depth of 594 m, Crater Lake is the deepest lake in the United States. Crater Lake National Park, dedicated in 1902, encompasses 645 km2 of pristine forested and alpine terrain, including the lake itself, virtually all of Mount Mazama, and most of the area of the geologic map. The geology of the area was first described in detail by Diller and Patton (1902) and later by Williams (1942), whose vivid account led to international recognition of Crater Lake as the classic collapse caldera. Because of excellent preservation and access, Mount Mazama, Crater Lake caldera, and the deposits formed by the climactic eruption constitute a natural laboratory for study of volcanic and magmatic processes. For example, the climactic ejecta are renowned among volcanologists as evidence for systematic compositional zonation within a subterranean magma chamber. Mount Mazama's climactic eruption also is important as the source of the widespread Mazama ash, a useful Holocene stratigraphic marker throughout the Pacific Northwest, adjacent Canada, and offshore. A detailed bathymetric survey of the floor of Crater Lake in 2000 (Bacon and others, 2002) provides a unique record of postcaldera eruptions, the interplay between volcanism and filling of the lake, and sediment transport within this closed basin. Knowledge of the geology and eruptive history of the Mount Mazama edifice, greatly enhanced by the caldera wall exposures, gives exceptional insight into how large volcanoes of magmatic arcs grow and evolve. Lastly, the many smaller volcanoes of the High Cascades beyond the limits of Mount Mazama are a source of information on the flux of mantle-derived magma through the region. General principles of magmatic and eruptive

76 FR 19125 - Bottom Mount Combination Refrigerator-Freezers From Korea and Mexico

Science.gov (United States)

2011-04-06

...)] Bottom Mount Combination Refrigerator-Freezers From Korea and Mexico AGENCY: United States International... bottom mount combination refrigerator-freezers from Korea and Mexico, provided for in subheadings 8418.10... five business days thereafter, or by May 23, 2011. For further information concerning the conduct of...

Biodiversity of the flora of Mount Papa

International Nuclear Information System (INIS)

Yin-Yin-Kyi

1995-07-01

Even though Mount Papa is in the dry zone area, it is almost evergreen, due to its elevation of 4981 feet above the sea level and its fertile soil conditions. A has a rich biodiversity with vegetation of many types

Fathead minnow whole-mount in situ hybridization (WISH)

Data.gov (United States)

U.S. Environmental Protection Agency — This study demonstrates the potential of whole-mount in situ hybridization (WISH), in conjunction with quantitative real-time polymerase chain reaction (QPCR)...

Aerodynamic interaction effects of tip-mounted propellers installed on the horizontal tailplane

NARCIS (Netherlands)

van Arnhem, N.; Sinnige, T.; Stokkermans, T.C.A.; Eitelberg, G.; Veldhuis, L.L.M.

2018-01-01

This paper addresses the effects of propeller installation on the aerodynamic performance of a tailplane featuring tip-mounted propellers. A model of a low aspect ratio tailplane equipped with an elevator and a tip-mounted propeller was installed in a low-speed wind-tunnel. Measurements were

Wirebond crosstalk and cavity modes in large chip mounts for superconducting qubits

Energy Technology Data Exchange (ETDEWEB)

Wenner, J; Neeley, M; Bialczak, Radoslaw C; Lenander, M; Lucero, Erik; O' Connell, A D; Sank, D; Wang, H; Weides, M; Cleland, A N; Martinis, John M, E-mail: martinis@physics.ucsb.edu [Department of Physics, University of California, Santa Barbara, CA 93106 (United States)

2011-06-15

We analyze the performance of a microwave chip mount that uses wirebonds to connect the chip and mount grounds. A simple impedance ladder model predicts that transmission crosstalk between two feedlines falls off exponentially with distance at low frequencies, but rises to near unity above a resonance frequency set by the chip to ground capacitance. Using SPICE simulations and experimental measurements of a scale model, the basic predictions of the ladder model were verified. In particular, by decreasing the capacitance between the chip and box grounds, the resonance frequency increased and transmission decreased. This model then influenced the design of a new mount that improved the isolation to - 65 dB at 6 GHz, even though the chip dimensions were increased to 1 cm x 1 cm, three times as large as our previous devices. We measured a coplanar resonator in this mount as preparation for larger qubit chips, and were able to identify cavity, slotline, and resonator modes.

Wirebond crosstalk and cavity modes in large chip mounts for superconducting qubits

International Nuclear Information System (INIS)

Wenner, J; Neeley, M; Bialczak, Radoslaw C; Lenander, M; Lucero, Erik; O'Connell, A D; Sank, D; Wang, H; Weides, M; Cleland, A N; Martinis, John M

2011-01-01

We analyze the performance of a microwave chip mount that uses wirebonds to connect the chip and mount grounds. A simple impedance ladder model predicts that transmission crosstalk between two feedlines falls off exponentially with distance at low frequencies, but rises to near unity above a resonance frequency set by the chip to ground capacitance. Using SPICE simulations and experimental measurements of a scale model, the basic predictions of the ladder model were verified. In particular, by decreasing the capacitance between the chip and box grounds, the resonance frequency increased and transmission decreased. This model then influenced the design of a new mount that improved the isolation to - 65 dB at 6 GHz, even though the chip dimensions were increased to 1 cm x 1 cm, three times as large as our previous devices. We measured a coplanar resonator in this mount as preparation for larger qubit chips, and were able to identify cavity, slotline, and resonator modes.

Bearing-Mounting Concept Accommodates Thermal Expansion

Science.gov (United States)

Nespodzany, Robert; Davis, Toren S.

1995-01-01

Pins or splines allow radial expansion without slippage. Design concept for mounting rotary bearing accommodates differential thermal expansion between bearing and any structure(s) to which bearing connected. Prevents buildup of thermal stresses by allowing thermal expansion to occur freely but accommodating expansion in such way not to introduce looseness. Pin-in-slot configuration also maintains concentricity.

Fixture For Mounting A Pressure Sensor

Science.gov (United States)

Cagle, Christopher M.

1995-01-01

Fixture for mounting pressure sensor in aerodynamic model simplifies task of removal and replacement of sensor in event sensor becomes damaged. Makes it unnecessary to dismantle model. Also minimizes any change in aerodynamic characteristics of model in event of replacement. Removable pressure sensor installed in fixture in wall of model. Wires from sensor pass through channel under surface.

GLA-SE, a Synthetic Toll-like Receptor 4 Agonist, Enhances T-Cell Responses to Influenza Vaccine in Older Adults

NARCIS (Netherlands)

Behzad, Hayedeh; Huckriede, Anke L. W.; Haynes, Laura; Gentleman, Beth; Coyle, Krysta; Wilschut, Jan C.; Kollmann, Tobias R.; Reed, Steven G.; McElhaney, Janet E.

2012-01-01

Background. The decline in influenza vaccine efficacy in older adults is associated with a limited ability of current split-virus vaccines (SVVs) to stimulate cytotoxic T lymphocyte (CTL) responses required for clinical protection against influenza. Methods. The Toll-like receptor 4 agonist

The Effects of Degradational Factors on the Ecosystem of Mount Madra

Science.gov (United States)

Efe, R.; Soykan, A.; Sönmez, S.; Cürebal, I.

2009-04-01

Significant degradation has been observed in Turkey's Mediterranean woodlands and mountainous areas. Mediterranean climate prevails in the southern and western part of Turkey. Mount Madra, which is located on Turkey's western Aegean coast, is part of a rangeland which is particularly exposed to the effects of degradation resulting from human activities. The principal factors in the degradation are inappropriate land use, destruction of forests, mining, construction, overgrazing and transhumance. Mount Madra and its environs benefit from a Mediterranean climate, experiencing dry, hot summers and cool, wet winters. The average yearly rainfall is 700-1000 mm, of which most occurs in the winter months. The mountain extends from east to west, and between the South and North slopes there is great variety in terms of plant species and biodiversity. The regeneration of the lost plant cover has been hindered by the mountain's geomorphologic characteristics. The slopes have suffered destruction of vegetation and, as a result of severe erosion, the soil has been swept away and in many places the bedrock has become exposed. The Kozak plateau on mount Madra is notable for the richness of its natural vegetation. This plateau, covered in pine forest (Pinus pinea), is the site for the traditional transhumance of over 500 families. Pine nuts and livestock breeding are livelihood of these families. Mount Madra and its surrounding area is one of the most important locations with gold mining potential in Turkey and it is estimated that it has 16.7 tons of gold reserve. The gold mining which took place on the west of the Madra Mountain around Ovacik village in 1994 led to serious land degradation in the surrounding area. The new mining on the study area and the proposed feldspar mining on the Madra riverbed poses a serious threat to the region's ecosystem and biodiversity. The removal of increasing amounts of granite and other quarrying has had a negative impact on the natural

A methodology for estimating the volume of Baltic timber to Spain using the Sound Toll Registers : 1670-1806

NARCIS (Netherlands)

Gallagher, Nathan

2016-01-01

The Sound Toll Registers Online project has opened a trove of information for historians, but calculating the actual volume of the trade it represents remains a challenge. Attempts have been made for products that were measured in weight or volume, but timber products were usually recorded by the

Mesenchymal stem cells cannot affect mRNA expression of toll-like receptors in different tissues during sepsis.

Science.gov (United States)

Pedrazza, Leonardo; Pereira, Talita Carneiro Brandão; Abujamra, Ana Lucia; Nunes, Fernanda Bordignon; Bogo, Maurício Reis; de Oliveira, Jarbas Rodrigues

2017-07-01

Experimental animal models and human clinical studies support a crucial role for TLRs in infectious diseases. The aim of this study was to test the ability of MSCs, which have immunomodulatory effects, of altering the mRNA expression of toll-like receptors during a experimental model of sepsis in different tissues. Three experimental groups (male C57BL/6 mice) were formed for the test: control group, untreated septic group and septic group treated with MSCs (1 × 10 6 cells/animal). Lungs, cortex, kidney, liver and colon tissue were dissected after 12 h of sepsis induction and TLR2/3/4/9 mRNA were evaluated by RT-qPCR. We observed a decrease of TLR2 and 9 mRNA expression in the liver of the sepsis group, while TLR3 was decreased in the lung and liver. No change was found between the sepsis group and the sepsis + MSC group. In this model of experimental sepsis the MSCs were unable to modify the mRNA expression of the different toll-like receptors evaluated.

Reactive oxygen species-dependent Toll/NF-κB activation in the Drosophila hematopoietic niche confers resistance to wasp parasitism.

Science.gov (United States)

Louradour, Isabelle; Sharma, Anurag; Morin-Poulard, Ismael; Letourneau, Manon; Vincent, Alain; Crozatier, Michèle; Vanzo, Nathalie

2017-11-01

Hematopoietic stem/progenitor cells in the adult mammalian bone marrow ensure blood cell renewal. Their cellular microenvironment, called 'niche', regulates hematopoiesis both under homeostatic and immune stress conditions. In the Drosophila hematopoietic organ, the lymph gland, the posterior signaling center (PSC) acts as a niche to regulate the hematopoietic response to immune stress such as wasp parasitism. This response relies on the differentiation of lamellocytes, a cryptic cell type, dedicated to pathogen encapsulation and killing. Here, we establish that Toll/NF-κB pathway activation in the PSC in response to wasp parasitism non-cell autonomously induces the lymph gland immune response. Our data further establish a regulatory network where co-activation of Toll/NF-κB and EGFR signaling by ROS levels in the PSC/niche controls lymph gland hematopoiesis under parasitism. Whether a similar regulatory network operates in mammals to control emergency hematopoiesis is an open question.

The influence of economic incentives linked to road safety indicators on accidents: the case of toll concessions in Spain.

Science.gov (United States)

Rangel, Thais; Vassallo, José Manuel; Herraiz, Israel

2013-10-01

The goal of this paper is to evaluate whether the incentives incorporated in toll highway concession contracts in order to encourage private operators to adopt measures to reduce accidents are actually effective at improving safety. To this end, we implemented negative binomial regression models using information about highway characteristics and accident data from toll highway concessions in Spain from 2007 to 2009. Our results show that even though road safety is highly influenced by variables that are not managed by the contractor, such as the annual average daily traffic (AADT), the percentage of heavy vehicles on the highway, number of lanes, number of intersections and average speed; the implementation of these incentives has a positive influence on the reduction of accidents and injuries. Consequently, this measure seems to be an effective way of improving safety performance in road networks. Copyright © 2013 Elsevier Ltd. All rights reserved.

The toll of the gridiron: damage-associated molecular patterns and hypertension in American football

Science.gov (United States)

McCarthy, Cameron G.; Webb, R. Clinton

2016-01-01

American football has unequivocally been linked to elevations in blood pressure and hypertension, especially in linemen. However, the mechanisms of this increase cannot be attributed solely to increased body weight and associated cardiometabolic risk factors (e.g.,dyslipidemia or hyperglycemia). Therefore, understanding the etiology of football-associated hypertension is essential for improving the quality of life in this mostly young population, as well as for lowering the potential for chronic disease in the future. We propose that inflammatogenic damage–associated molecular patterns (DAMPs) released into the circulation from football-induced musculoskeletal trauma activate pattern-recognition receptors of the innate immune system—specifically, high mobility group box 1 protein (HMGB1) and mitochondrial (mt)DNA which activate Toll-like receptor (TLR)4 and -9, respectively. Previously, we observed that circulating levels of these 2 DAMPs are increased in hypertension, and activation of TLR4 and -9 causes endothelial dysfunction and hypertension. Therefore, our novel hypothesis is that musculoskeletal injury from repeated hits in football players, particularly in linemen, leads to elevated circulating HMGB1 and mtDNA to activate TLRs on endothelial cells leading to impaired endothelium-dependent vasodilation, increased vascular tone, and hypertension.—McCarthy, C. G., Webb, R. C. The toll of the gridiron: damage-associated molecular patterns and hypertension in American football. PMID:26316270

Paediatric death and dying: exploring coping strategies of health professionals and perceptions of support provision.

Science.gov (United States)

Forster, Elizabeth; Hafiz, Alaa

2015-06-01

Without question a child's death is a devastating event for parents and families. Health professionals working with the dying child and family draw upon their expertise and experience to engage with children, parents and families on this painful journey. This is a delicate and sensitive area of practice and has strong and penetrating effects on health professionals. They employ physical, emotional, spiritual and problem solving strategies to continue to perform this role effectively and to protect their continued sense of wellbeing. To explore health professionals' perceptions of bereavement support surrounding the loss of a child. The research was underpinned by social constructionism. Semi-structured interviews were held with 10 health professionals including doctors, nurses and social workers who were directly involved in the care of the dying child and family in 7 cases of paediatric death. Health professional narratives were analysed consistent with Charmarz's (2006) approach. For health professionals, constructions around coping emerged as peer support, personal coping strategies, family support, physical impact of support and spiritual beliefs. Analysis of the narratives also revealed health professionals' perceptions of their support provision. Health professionals involved in caring for dying children and their families use a variety of strategies to cope with the emotional and physical toll of providing support. They also engage in self-assessment to evaluate their support provision and this highlights the need for self-evaluation tools in paediatric palliative care.

Fluorescent visualization of macromolecules in Drosophila whole mounts.

Science.gov (United States)

Ramos, Ricardo Guelerman Pinheiro; Machado, Luciana Claudia Herculano; Moda, Livia Maria Rosatto

2010-01-01

The ability to determine the expression dynamics of individual genes "in situ" by visualizing the precise spatial and temporal distribution of their products in whole mounts by histochemical and immunocytochemical reactions has revolutionized our understanding of cellular processes. Drosophila developmental genetics was one of the fields that benefited most from these technologies, and a variety of fluorescent methods were specifically designed for investigating the localization of developmentally important proteins and cell markers during embryonic and post embryonic stages of this model organism. In this chapter we present detailed protocols for fluorescence immunocytochemistry of whole mount embryos, imaginal discs, pupal retinas, and salivary glands of Drosophila melanogaster, as well as methods for fluorescent visualization of specific subcellular structures in these tissues.

Life Experience with Death: Relation to Death Attitudes and to the Use of Death-Related Memories

Science.gov (United States)

Bluck, Susan; Dirk, Judith; Mackay, Michael M.; Hux, Ashley

2008-01-01

The study examines the relation of death experience to death attitudes and to autobiographical memory use. Participants (N = 52) completed standard death attitude measures and wrote narratives about a death-related autobiographical memory and (for comparison) a memory of a low point. Self-ratings of the memory narratives were used to assess their…

Challenges of raising road maintenance funds in developing countries: An analysis of road tolling in Zimbabwe

Directory of Open Access Journals (Sweden)

T. C. Mbara

2010-11-01

Full Text Available The condition of Zimbabwe's roads has been declining due to insufficient maintenance and rehabilitation. Year on year, budget allocations have compared unfavourably with funding considered adequate to maintain highway networks and conduct modest construction work. Road infrastructure shortcomings have manifested themselves in the form of high vehicle operating costs and rampant potholes, leading to a decline in road safety and a deterioration of service levels for those who use roads to deliver goods or connect to international markets. In order to try and stop this vicious cycle of decline, the Government of Zimbabwe, on 8 August 2009, introduced a new policy of road-user charges, which involved the setting-up of 22 toll gates on the trunk road network. The overall objective was to raise revenue in order to close the funding gap, blamed for declining road quality. Although alternative methods of financing road maintenance have been debated for years, a generally accepted understanding is that road users should pay costs for road provisioning. This paper assesses the implementation of a road tolling system in Zimbabwe and describes matters relating to, inter alia, implementation strategy, initial performance outcomes and sustainability.

Genetic structure of Mount Huang honey bee (Apis cerana) populations: evidence from microsatellite polymorphism.

Science.gov (United States)

Liu, Fang; Shi, Tengfei; Huang, Sisi; Yu, Linsheng; Bi, Shoudong

2016-01-01

The Mount Huang eastern honey bees ( Apis cerana ) are an endemic population, which is well adapted to the local agricultural and ecological environment. In this study, the genetic structure of seven eastern honey bees ( A. cerana ) populations from Mount Huang in China were analyzed by SSR (simple sequence repeat) markers. The results revealed that 16 pairs of primers used amplified a total of 143 alleles. The number of alleles per locus ranged from 6 to 13, with a mean value of 8.94 alleles per locus. Observed and expected heterozygosities showed mean values of 0.446 and 0.831 respectively. UPGMA cluster analysis grouped seven eastern honey bees in three groups. The results obtained show a high genetic diversity in the honey bee populations studied in Mount Huang, and high differentiation among all the populations, suggesting that scarce exchange of honey bee species happened in Mount Huang. Our study demonstrated that the Mount Huang honey bee populations still have a natural genome worth being protected for conservation.

Method and apparatus for mounting or dismounting a semi-automatic twist-lock

NARCIS (Netherlands)

Klein Breteler, A.J.; Tekeli, G.

2001-01-01

The invention relates to a method for mounting or dismounting a semi-automatic twistlock at a corner of a deck container, wherein the twistlock is mounted or dismounted on a quayside where a ship may be docked for loading or unloading, in a loading or unloading terminal installed on the quayside,

The role of MAPK in CD4{sup +} T cells toll-like receptor 9-mediated signaling following HHV-6 infection

Energy Technology Data Exchange (ETDEWEB)

Chi, Jing [Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, Jiangsu Province (China); Wang, Fang [Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province (China); Li, Lingyun [Department of Developmental Genetics, Nanjing Medical University, Nanjing 210029, Jiangsu Province (China); Feng, Dongju [Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, Jiangsu Province (China); Qin, Jian [College of Foreign Languages, Hehai University, Nanjing 210029, Jiangsu Province (China); Xie, Fangyi; Zhou, Feng; Chen, Yun; Wang, Jinfeng [Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, Jiangsu Province (China); Yao, Kun, E-mail: yaokun@njmu.edu.cn [Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, Jiangsu Province (China)

2012-01-05

Human herpesvirus-6 (HHV-6) is an important immunosuppressive and immunomodulatory virus that primarily infects immune cells (mainly CD4{sup +} T cells) and strongly suppresses the proliferation of infected cells. Toll-like receptors are pattern-recognition receptors essential for the development of an appropriate innate immune defense against infection. To understand the role of CD4{sup +} T cells in the innate response to HHV-6 infection and the involvement of TLRs, we used an in vitro infection model and observed that the infection of CD4{sup +} T cells resulted in the activation of JNK/SAPK via up-regulation of toll-like receptor 9 (TLR9). Associated with JNK activation, annexin V-PI staining indicated that HHV-6A was a strong inducer of apoptosis. Apoptotic response associated cytokines, IL-6 and TNF-{alpha} also induced by HHV-6A infection.

Toll-Like Receptors in the Pathogenesis of Autoimmune Diseases

Science.gov (United States)

Mohammad Hosseini, Akbar; Majidi, Jafar; Baradaran, Behzad; Yousefi, Mehdi

2015-01-01

Human Toll-like receptors (TLRs) are a family of transmembrane receptors, which play a key role in both innate and adaptive immune responses. Beside of recognizing specific molecular patterns that associated with different types of pathogens, TLRs may also detect a number of self-proteins and endogenous nucleic acids. Activating TLRs lead to the heightened expression of various inflammatory genes, which have a protective role against infection. Data rising predominantly from human patients and animal models of autoimmune disease indicate that, inappropriate triggering of TLR pathways by exogenous or endogenous ligands may cause the initiation and/or perpetuation of autoimmune reactions and tissue damage. Given their important role in infectious and non-infectious disease process, TLRs and its signaling pathways emerge as appealing targets for therapeutics. In this review, we demonstrate how TLRs pathways could be involved in autoimmune disorders and their therapeutic application. PMID:26793605

Local Sabahans’ Satisfaction with Level of Access to Mount Kinabalu

Directory of Open Access Journals (Sweden)

Bidder Christy

2014-01-01

Full Text Available This study analyzes the local Sabahans’ satisfaction with the level of access to Mount Kinabalu in Sabah, Malaysian Borneo. Specifically, it examines the number of complaints by local Sabahans regarding access and their perception of changes in accessibility to the mountain. Interviews with Sabah Parks and Sutera Sanctuary Lodges were conducted and questionnaires were distributed to local residents to collect data. The results show that there were intense complaints regarding the climbing cost and extensive waiting time to secure a confirmed booking at the outset of price increases. However, the researchers could not locate any recently published complaints. Respondents who have previously climbed Mount Kinabalu perceive the mountain to be less accessible for local Sabahans now due to a less affordable cost and a longer waiting time. Those who have not climbed Mount Kinabalu also think the climbing cost has become less affordable for local Sabahans, but they do not perceive that to be causing the mountain less accessible for local Sabahans.

A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity.

Directory of Open Access Journals (Sweden)

Nicholas D Leigh

Full Text Available Toll-like receptor (TLR mediated recognition of pathogen associated molecular patterns allows the immune system to rapidly respond to a pathogenic insult. The "danger context" elicited by TLR agonists allows an initially non-immunogenic antigen to become immunogenic. This ability to alter environment is highly relevant in tumor immunity, since it is inherently difficult for the immune system to recognize host-derived tumors as immunogenic. However, immune cells may have encountered certain TLR ligands associated with tumor development, yet the endogenous stimulation is typically not sufficient to induce spontaneous tumor rejection. Of special interest are TLR5 agonists, because there are no endogenous ligands that bind TLR5. CBLB502 is a pharmacologically optimized TLR5 agonist derived from Salmonella enterica flagellin. We examined the effect of CBLB502 on tumor immunity using two syngeneic lymphoma models, both of which do not express TLR5, and thus do not directly respond to CBLB502. Upon challenge with the T-cell lymphoma RMAS, CBLB502 treatment after tumor inoculation protects C57BL/6 mice from death caused by tumor growth. This protective effect is both natural killer (NK cell- and perforin-dependent. In addition, CBLB502 stimulates clearance of the B-cell lymphoma A20 in BALB/c mice in a CD8(+ T cell-dependent fashion. Analysis on the cellular level via ImageStream flow cytometry reveals that CD11b(+ and CD11c(+ cells, but neither NK nor T cells, directly respond to CBLB502 as determined by NFκB nuclear translocation. Our findings demonstrate that CBLB502 stimulates a robust antitumor response by directly activating TLR5-expressing accessory immune cells, which in turn activate cytotoxic lymphocytes.

Nonlinear adaptive observer-based sliding mode control for LAMOST mount driving

International Nuclear Information System (INIS)

Zhou Wangping; Guo Wei; Yu Li; Yang Changsong; Zheng Yi

2010-01-01

Heavy disturbances caused mainly by wind and friction in the mount drive system greatly impair the pointing accuracy of the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST). To overcome this negative effect, a third order Higher Order Sliding Mode (HOSM) controller is proposed. The key part of this approach is to design an appropriate observer which obtains the acceleration state. A nonlinear adaptive observer is proposed in which a novel polynomial model is applied to estimate the internal disturbances of the mount drive system. Theoretical analysis demonstrates the stability of the proposed observer. Simulation results show that this nonlinear adaptive observer can obtain a high precision acceleration signal which completes the HOSM controller. Furthermore, the HOSM approach can easily satisfy the position tracking requirements of the LAMOST mount drive system.

Advanced semi-active engine and transmission mounts: tools for modelling, analysis, design, and tuning

Science.gov (United States)

Farjoud, Alireza; Taylor, Russell; Schumann, Eric; Schlangen, Timothy

2014-02-01

This paper is focused on modelling, design, and testing of semi-active magneto-rheological (MR) engine and transmission mounts used in the automotive industry. The purpose is to develop a complete analysis, synthesis, design, and tuning tool that reduces the need for expensive and time-consuming laboratory and field tests. A detailed mathematical model of such devices is developed using multi-physics modelling techniques for physical systems with various energy domains. The model includes all major features of an MR mount including fluid dynamics, fluid track, elastic components, decoupler, rate-dip, gas-charged chamber, MR fluid rheology, magnetic circuit, electronic driver, and control algorithm. Conventional passive hydraulic mounts can also be studied using the same mathematical model. The model is validated using standard experimental procedures. It is used for design and parametric study of mounts; effects of various geometric and material parameters on dynamic response of mounts can be studied. Additionally, this model can be used to test various control strategies to obtain best vibration isolation performance by tuning control parameters. Another benefit of this work is that nonlinear interactions between sub-components of the mount can be observed and investigated. This is not possible by using simplified linear models currently available.

Vibration aging of diesel-engine mounted electrical equipment

International Nuclear Information System (INIS)

Lee, B.J.; Morton, W.C.

1994-01-01

The Emergency Diesel Generator (EDG) in a Nuclear Power Plant is considered to be a component which is essential to safe plant operation. Failures of auxiliary equipment directly mounted on the EDG creates costly repairs, and compromises the engine's availability and reliability. Although IEEE-323 requires addressing of safety-related components due to mechanically induced vibration, very few guidelines exist in the nuclear industry to show how this may be accounted for. Most engine vendors rely on the empirical experience data as the basis of their evaluation for vibration. Upgrade of engine controls, addition of monitoring devices and other engine modifications require design and installation of new equipment to be mounted directly on the engine. This necessitates the evaluation for engine-induced vibration which is considered to be one of the most severe design parameters. This paper discusses the engine vibration characteristics, and the acquisition of extensive field vibration data on the diesel engine under operating conditions. The data is then used to develop life cycle vibration qualification test profiles that can be applied with confidence in a laboratory environment to qualify engine-mounted equipment. The intent is to validate a product's ability to survive under worst case, extended service on-engine conditions. This paper describes the procedures and approaches used to achieve those goals, and provides developed profile examples and test results

Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: interrupted time series analyses

Science.gov (United States)

Bergen, Helen; Simkin, Sue; Dodd, Sue; Pocock, Phil; Bernal, William; Gunnell, David; Kapur, Navneet

2013-01-01

paracetamol was followed by significant reductions in deaths due to paracetamol overdose, with some indication of fewer registrations for transplantation at liver units during the 11 years after the legislation. The continuing toll of deaths suggests, however, that further preventive measures should be sought. PMID:23393081

Conceptual Design of Bottom-mounted Control Rod Drive Mechanism

International Nuclear Information System (INIS)

Lee, Jin Haeng; Kim, Sanghaun; Yoo, Yeonsik; Cho, Yeonggarp; Kim, Dongmin; Kim, Jong In

2013-01-01

The arrangement of the BMCRDMs and irradiation holes in the core is therefore easier than that of the top-mounted CRDM. Hence, many foreign research reactors, such as JRR-3M, JMTR, OPAL, and CARR, have adopted the BMCRDM concept. The purpose of this paper is to introduce the basic design concept on the BMCRDM. The major differences of the CRDMs between HANARO and KJRR are compared, and the design features and individual system of the BMCRDM for the KJRR are described. The Control Rod Drive Mechanism (CRDM) is a device to regulate the reactor power by changing the position of a Control Absorber Rod (CAR) and to shut down the reactor by fully inserting the CAR into the core within a specified time. The Bottom-Mounted CRDM (BMCRDM) for the KiJang Research Reactor (KJRR) is a quite different design concept compared to the top-mounted CRDM such as HANARO and JRTR. The main drive mechanism of the BMCRDM is located in a Reactivity Control Mechanism (RCM) room under the reactor pool bottom, which makes the interference with equipment in the reactor pool reduced

Conceptual Design of Bottom-mounted Control Rod Drive Mechanism

Energy Technology Data Exchange (ETDEWEB)

Lee, Jin Haeng; Kim, Sanghaun; Yoo, Yeonsik; Cho, Yeonggarp; Kim, Dongmin; Kim, Jong In [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2013-05-15

The arrangement of the BMCRDMs and irradiation holes in the core is therefore easier than that of the top-mounted CRDM. Hence, many foreign research reactors, such as JRR-3M, JMTR, OPAL, and CARR, have adopted the BMCRDM concept. The purpose of this paper is to introduce the basic design concept on the BMCRDM. The major differences of the CRDMs between HANARO and KJRR are compared, and the design features and individual system of the BMCRDM for the KJRR are described. The Control Rod Drive Mechanism (CRDM) is a device to regulate the reactor power by changing the position of a Control Absorber Rod (CAR) and to shut down the reactor by fully inserting the CAR into the core within a specified time. The Bottom-Mounted CRDM (BMCRDM) for the KiJang Research Reactor (KJRR) is a quite different design concept compared to the top-mounted CRDM such as HANARO and JRTR. The main drive mechanism of the BMCRDM is located in a Reactivity Control Mechanism (RCM) room under the reactor pool bottom, which makes the interference with equipment in the reactor pool reduced.

On-field mounting position estimation of a lidar sensor

Science.gov (United States)

Khan, Owes; Bergelt, René; Hardt, Wolfram

2017-10-01

In order to retrieve a highly accurate view of their environment, autonomous cars are often equipped with LiDAR sensors. These sensors deliver a three dimensional point cloud in their own co-ordinate frame, where the origin is the sensor itself. However, the common co-ordinate system required by HAD (Highly Autonomous Driving) software systems has its origin at the center of the vehicle's rear axle. Thus, a transformation of the acquired point clouds to car co-ordinates is necessary, and thereby the determination of the exact mounting position of the LiDAR system in car coordinates is required. Unfortunately, directly measuring this position is a time-consuming and error-prone task. Therefore, different approaches have been suggested for its estimation which mostly require an exhaustive test-setup and are again time-consuming to prepare. When preparing a high number of LiDAR mounted test vehicles for data acquisition, most approaches fall short due to time or money constraints. In this paper we propose an approach for mounting position estimation which features an easy execution and setup, thus making it feasible for on-field calibration.

Association Between Symptom Burden and Time to Hospitalization, Nursing Home Placement, and Death Among the Chronically Ill Urban Homebound.

Science.gov (United States)

Yang, Nancy; Ornstein, Katherine A; Reckrey, Jennifer M

2016-07-01

Homebound adults experience significant symptom burden. To examine demographic and clinical characteristics associated with high symptom burden in the homebound, and to examine associations between symptom burden and time to hospitalization, nursing home placement, and death. Three hundred eighteen patients newly enrolled in the Mount Sinai Visiting Doctors Program, an urban home-based primary care program, were studied. Patient sociodemographic characteristics, symptom burden (measured via the Edmonton Symptom Assessment Scale), and incidents of hospitalization, nursing home placement, and death were collected via medical chart review. Multivariate Cox proportional hazards models were used to analyze the effect of high symptom burden on time to first hospitalization, nursing home placement, and death. Of the study sample, 45% had severe symptom burden (i.e., Edmonton Symptom Assessment Scale score >6 on at least one symptom). Patients with severe symptom burden were younger (82.0 vs. 85.5 years, P nursing home placement or death. The homebound with severe symptom burden represents a unique cohort of patients who are at increased risk of hospitalization. Tailored symptom management via home-based primary and palliative care programs may prevent unnecessary health care utilization in this population. Copyright © 2016 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

Multilayer mounting for long-term light sheet microscopy of zebrafish.

Science.gov (United States)

Weber, Michael; Mickoleit, Michaela; Huisken, Jan

2014-02-27

Light sheet microscopy is the ideal imaging technique to study zebrafish embryonic development. Due to minimal photo-toxicity and bleaching, it is particularly suited for long-term time-lapse imaging over many hours up to several days. However, an appropriate sample mounting strategy is needed that offers both confinement and normal development of the sample. Multilayer mounting, a new embedding technique using low-concentration agarose in optically clear tubes, now overcomes this limitation and unleashes the full potential of light sheet microscopy for real-time developmental biology.

Development of a helmet-mounted PLZT thermal/flash protection system

International Nuclear Information System (INIS)

Harris, J.O. Jr.; Cutchen, J.T.; Pfoff, B.J.

1976-01-01

Sandia Laboratories is developing PLZT thermal/flash protective devices (TFPD's) goggles to prevent exposure and resultant eye damage from nuclear weapon detonations. The primary emphasis of the present program is to transfer technology and establish production capability for helmet-mounted PLZT/TFPD goggles for USAF flight crews, with a non-helmet-mounted configuration to follow. The first production units are anticipated in the fall of 1977. The operating principles of the PLZT/TFPD goggle device are briefly outlined, and the device configuration and operational characteristics are described

Creating Gaze Annotations in Head Mounted Displays

DEFF Research Database (Denmark)

Mardanbeigi, Diako; Qvarfordt, Pernilla

2015-01-01

To facilitate distributed communication in mobile settings, we developed GazeNote for creating and sharing gaze annotations in head mounted displays (HMDs). With gaze annotations it possible to point out objects of interest within an image and add a verbal description. To create an annota- tion...

Solidly Mounted Resonator with Optimized Acoustic Reflector

NARCIS (Netherlands)

Jose, Sumy; Jansman, Andreas; Hueting, Raymond Josephus Engelbart

2009-01-01

The quality factor (Q) of the Solidly Mounted Resonator is limited by acoustic losses caused by waves leaking through the mirror stack. Traditionally employed acoustic mirror reflects only longitudinal waves and not shear waves. Starting with the stop-band theory and the principle of spacer layers

On Stackelberg and Inverse Stackelberg Games and Their Applications in the Optimal Toll Design Problem, the Energy Markets Liberalization Problem, and in the Theory of Incentives

Energy Technology Data Exchange (ETDEWEB)

Stankova, K.

2009-02-02

Inverse (or reverse) Stackelberg games have become the subject of recent game theory research, as a special type or as an extension of Stackelberg games. So far, only very little theory about inverse Stackelberg games is available and the available theory is still in its infancy. In this thesis we focus on theoretically solving such problems and we propose to treat several challenging problems in various fields inside this framework. In Stackelberg games a so-called leader determines actions for one or more so-called followers. The problem of finding an optimal strategy for the leader in these games is in general extremely hard to solve, and often even completely unsolvable. Starting from simple static problems and proceeding to more difficult dynamic ones, we show how to find the optimal strategy for the leader in a heuristic manner. In this thesis, the application of game theory is proposed in the following domains: The optimal toll design problem, the electricity markets liberalization problem, and the theory of incentives. The optimal toll design problem is a game of the Stackelberg type in which a road authority acts as the leader and drivers in the road network act as the followers. The road authority sets tolls on some of the links in the network in order to maximize its objective function, while the drivers make their travel decisions in order to minimize their perceived travel costs. If the toll that the road authority sets is traffic-flow invariant, the problem is the 'classical' Stackelberg game; if the toll is traffic-flow dependent, the problem is of the inverse Stackelberg type. We determine the optimal traffic-flow dependent toll for the road authority for both static and dynamic variants of the problem. If the solution concept for the drivers' behavior is the deterministic user equilibrium, the problem can be dealt with analytically. If the stochastic user equilibrium applies, numerical methods have to be applied to find a solution

On Stackelberg and Inverse Stackelberg Games and Their Applications in the Optimal Toll Design Problem, the Energy Markets Liberalization Problem, and in the Theory of Incentives

International Nuclear Information System (INIS)

Stankova, K.

2009-01-01

Inverse (or reverse) Stackelberg games have become the subject of recent game theory research, as a special type or as an extension of Stackelberg games. So far, only very little theory about inverse Stackelberg games is available and the available theory is still in its infancy. In this thesis we focus on theoretically solving such problems and we propose to treat several challenging problems in various fields inside this framework. In Stackelberg games a so-called leader determines actions for one or more so-called followers. The problem of finding an optimal strategy for the leader in these games is in general extremely hard to solve, and often even completely unsolvable. Starting from simple static problems and proceeding to more difficult dynamic ones, we show how to find the optimal strategy for the leader in a heuristic manner. In this thesis, the application of game theory is proposed in the following domains: The optimal toll design problem, the electricity markets liberalization problem, and the theory of incentives. The optimal toll design problem is a game of the Stackelberg type in which a road authority acts as the leader and drivers in the road network act as the followers. The road authority sets tolls on some of the links in the network in order to maximize its objective function, while the drivers make their travel decisions in order to minimize their perceived travel costs. If the toll that the road authority sets is traffic-flow invariant, the problem is the 'classical' Stackelberg game; if the toll is traffic-flow dependent, the problem is of the inverse Stackelberg type. We determine the optimal traffic-flow dependent toll for the road authority for both static and dynamic variants of the problem. If the solution concept for the drivers' behavior is the deterministic user equilibrium, the problem can be dealt with analytically. If the stochastic user equilibrium applies, numerical methods have to be applied to find a solution. As the problem

Beating-heart registration for organ-mounted robots.

Science.gov (United States)

Wood, Nathan A; Schwartzman, David; Passineau, Michael J; Moraca, Robert J; Zenati, Marco A; Riviere, Cameron N

2018-03-06

Organ-mounted robots address the problem of beating-heart surgery by adhering to the heart, passively providing a platform that approaches zero relative motion. Because of the quasi-periodic deformation of the heart due to heartbeat and respiration, registration must address not only spatial registration but also temporal registration. Motion data were collected in the porcine model in vivo (N = 6). Fourier series models of heart motion were developed. By comparing registrations generated using an iterative closest-point approach at different phases of respiration, the phase corresponding to minimum registration distance is identified. The spatiotemporal registration technique presented here reduces registration error by an average of 4.2 mm over the 6 trials, in comparison with a more simplistic static registration that merely averages out the physiological motion. An empirical metric for spatiotemporal registration of organ-mounted robots is defined and demonstrated using data from animal models in vivo. Copyright © 2018 John Wiley & Sons, Ltd.

Negative regulation of Toll-like receptor signalling 

Directory of Open Access Journals (Sweden)

Halina Antosz

2013-04-01

Full Text Available The mechanism of innate immunity is based on the pattern recognition receptors (PRR that recognize molecular patterns associated with pathogens (PAMPs. Among PRR receptors Toll-like receptors (TLR are distinguished. As a result of contact with pathogens, TLRs activate specific intracellular signaling pathways. It happens through proteins such as adaptor molecules, e.g. MyD88, TIRAP, TRIF, TRAM, and IPS-1, which participate in the cascade activation of kinases (IKK, MAP, RIP-1, TBK-1 as well as transcription factors (NF-κB, AP-1 and regulatory factor (IRF3. The result of this activation is the production of active proinflammatory cytokines, chemokines, interferons and enzymes. The PRR pathways are controlled by extra – and intracellular molecules to prevent overexpression of PRR. They include soluble receptors (sTLR, transmembrane proteins (ST2, SIGIRR, RP105, TRAIL-R and intracellular inhibitors (SOCS-1, SOCS-3, sMyD88, TOLLIP, IRAK-M, SARM, A20, β-arrestin, CYLD, SHP. These molecules maintain the balance between activation and inhibition and ensure balancing of the beneficial and adverse effects of antigen recognition.

Instrument-mounted displays for reducing cognitive load during surgical navigation.

Science.gov (United States)

Herrlich, Marc; Tavakol, Parnian; Black, David; Wenig, Dirk; Rieder, Christian; Malaka, Rainer; Kikinis, Ron

2017-09-01

Surgical navigation systems rely on a monitor placed in the operating room to relay information. Optimal monitor placement can be challenging in crowded rooms, and it is often not possible to place the monitor directly beside the situs. The operator must split attention between the navigation system and the situs. We present an approach for needle-based interventions to provide navigational feedback directly on the instrument and close to the situs by mounting a small display onto the needle. By mounting a small and lightweight smartwatch display directly onto the instrument, we are able to provide navigational guidance close to the situs and directly in the operator's field of view, thereby reducing the need to switch the focus of view between the situs and the navigation system. We devise a specific variant of the established crosshair metaphor suitable for the very limited screen space. We conduct an empirical user study comparing our approach to using a monitor and a combination of both. Results from the empirical user study show significant benefits for cognitive load, user preference, and general usability for the instrument-mounted display, while achieving the same level of performance in terms of time and accuracy compared to using a monitor. We successfully demonstrate the feasibility of our approach and potential benefits. With ongoing technological advancements, instrument-mounted displays might complement standard monitor setups for surgical navigation in order to lower cognitive demands and for improved usability of such systems.

Evaluation of shear mounted elastomeric damper

Science.gov (United States)

Zorzi, E.; Walton, J.

1982-01-01

Viton-70 elastomeric shear mounted damper was built and tested on a T-55 power turbine spool in the rotor's high speed balancing rig. This application of a shear mounted elastomeric damper demonstrated for the first time, the feasibility of using elastomers as the primary rotor damping source in production turbine engine hardware. The shear damper design was selected because it was compatible with actual gas turbine engine radial space constraints, could accommodate both the radial and axial thrust loads present in gas turbine engines, and was capable of controlled axial preload. The shear damper was interchangeable with the production T-55 power turbine roller bearing support so that a direct comparison between the shear damper and the production support structure could be made. Test results show that the Viton-70 elastomer damper operated successfully and provided excellent control of both synchronous and nonsynchronous vibrations through all phases of testing up to the maximum rotor speed of 16,000 rpm. Excellent correlation between the predicted and experienced critical speeds, mode shapes and log decrements for the power turbine rotor and elastomer damper assembly was also achieved.

Quality insights of university teachers on dying, death, and death education.

Science.gov (United States)

Mak, Mui-Hing June

One of the main responsibilities of teachers is to help individual students cope with life difficulties such as grief following a death. However, very little research explores teachers' views on death, dying, and how they handle grief and loss in schools. This study aims to explore university teachers' knowledge and attitudes on dying, death, and death education. Fifteen university teachers were recruited using a qualitative method. This study reveals that most teachers' views on death and related issues are largely affected by their death experiences, religious beliefs, professional background, and the mass media. Although they have a general negative response toward death and dying, some teachers begin to affirm their meanings of life and death. Most teachers agree that they do not feel adequate about managing and teaching on life and death issues, so they strongly support including death education in the formal programs in Hong Kong.

Evaluation of wind flow with a nacelle-mounted, continuous wave wind lidar

DEFF Research Database (Denmark)

Medley, John; Barker, Will; Harris, Mike

2014-01-01

Nacelle-mounted lidar is becoming widely recognized as a tool with potential for assessing power curves, understanding wind flow characteristics, and controlling turbines. As rotor diameters continue to increase, and the deployment of turbines in complex terrain becomes more widespread, knowledge...... mounted on the nacelle of a 550 kW turbine at the Risø campus of the Technical University of Denmark (DTU). Lidar measurements of wind speed and turbulence were compared against those made by anemometers on a high-quality traditional mast. Analysis showed excellent correlation between mast and Zeph...... that this is the first time that a commercially available nacelle-mounted lidar has been used to evaluate such rotor-equivalent power curves....

Costs of mounting an immune response during pregnancy in a lizard.

Science.gov (United States)

Meylan, Sandrine; Richard, Murielle; Bauer, Sophie; Haussy, Claudy; Miles, Donald

2013-01-01

Immune defenses are of great benefit to hosts, but reducing the impact of infection by mounting an immune response also entails costs. However, the physiological mechanisms that generate the costs of an immune response remain poorly understood. Moreover, the majority of studies investigating the consequences of an immune challenge in vertebrates have been conducted on mammals and birds. The aim of this study is to investigate the physiological costs of mounting an immune response during gestation in an ectothermic species. Indeed, because ectothermic species are unable to internally regulate their body temperature, the apportionment of resources to homeostatic activities in ectothermic species can differ from that in endothermic species. We conducted this study on the common lizard Zootoca vivipara. We investigated the costs of mounting an immune response by injecting females with sheep red blood cells and quantified the consequences to reproductive performance (litter mass and success) and physiological performance (standard metabolic rate, endurance, and phytohemagglutinin response). In addition, we measured basking behavior. Our analyses revealed that mounting an immune response affected litter mass, physiological performance, and basking behavior. Moreover, we demonstrated that the modulation of an immune challenge is impacted by intrinsic factors, such as body size and condition.

A new magnetorheological fluid–elastomer mount: phenomenological modeling and experimental study

International Nuclear Information System (INIS)

Wang, Xiaojie; Gordaninejad, Faramarz

2009-01-01

A new magnetorheological (MR) mount consisting of an MR fluid encapsulated in a polymeric solid is presented. The mechanical properties of the proposed mount are controllable through an externally applied magnetic field. The dynamic behavior of this system under various magnetic fields has been investigated by means of oscillatory compression cycles over a frequency range of 0.1–10 Hz for various deformations (less than 1 mm). The energy dissipation in the material is analyzed as related to strain amplitude, strain frequency and magnetic field strength. The field induced damping mechanism is discussed in terms of the damping exponent. A phenomenological model is presented to account for the dynamic behavior of the MR fluid–elastomer mount's vibration isolators under oscillatory compressive deformations. This model is a two-element system comprised of a variable friction damper and a nonlinear spring. The parameters of the model have been identified by a series of harmonic loading tests. The theoretical and experimental results are in excellent agreement. Both experimental and theoretical results have demonstrated that the proposed MR fluid–elastomer mounts show promise in applications where tuning vibration characteristics of a system are desired, such as altering natural frequencies, mode shapes, and damping properties

Mechanical Design of an Omni-Directional Sensor Mount

National Research Council Canada - National Science Library

Rosheim, Mark

2002-01-01

This effort has been directed to development and demonstration of a gimbal mount capable of 180 degree singularity- free pitch and yaw motion about a two-axis center, avoiding the common problem of gimbal lock...

Mounting and Alignment of Full-Shell Replicated X-Ray Optics

Science.gov (United States)

Gubarev, Mikhail; Arnold, William; Kester, Thomas; Ramsey, Brian; Smithers, Martin

2007-01-01

We are developing grazing-incidence x-ray optics for astronomy. The optics are full-cylinder mirror shells fabricated using electroformed-nickel replication off super-polished mandrels. For space-based applications where weight is at a premium, very-thin-walled, light-weight mirrors are required. Such shells have been fabricated at MSFC with greater than 15 arcsec resolution. The challenge, however, is to preserve this resolution during mounting and assembly. We present here a status report on a mounting and alignment system currently under development at Marshall Space Flight Center to meet this challenge.

An Experimental Study of a Sting-Mounted Circulation Control Wing

Science.gov (United States)

1991-12-01

atmospheric pressure was read from a Henry J. Green ML-330/FM mercury barometer and the desired tunnel q was determined from: q.)= 1/2 RTatms (21) F atmos C2...attachment to the Coanda surface. With the model mounted on a bench outside the tunnel, a fixture was attached to the model so that a pitot tube could be...mounted immediately aft of the blowing slot to measure jet total pressure at any point along the trailing edge. The pitot tube was connected to a 50 inch

Experimental study of some mounting brackets to support fuel elements

International Nuclear Information System (INIS)

Aubert, M.; Poglia, S.; Roche, R.

1958-09-01

In an atomic pile with vertical channels, fuel elements are stacked on one another. According to a possible assembly, fuel element can be contained by a graphite sleeve and be supported by a mounting bracket in this sleeve. Sleeves are then stacked on one another. The authors report the investigation of different designs for these mounting brackets. They describe their mechanical role and their mechanical, aerodynamic, neutronic and test conditions. They report tests performed on brackets made in graphite and on brackets made in stainless steel and graphite, and discuss the obtained results

Mount Sinai Hospital's approach to Ontario's Health System Funding Reform.

Science.gov (United States)

Chalk, Tyler; Lau, Davina; Morgan, Matthew; Dietrich, Sandra; Beduz, Mary Agnes; Bell, Chaim M

2014-01-01

In April 2012, the Ontario government introduced Health System Funding Reform (HSFR), a transformational shift in how hospitals are funded. Mount Sinai Hospital recognized that moving from global funding to a "patient-based" model would have substantial operational and clinical implications. Adjusting to the new funding environment was set as a top corporate priority, serving as the strategic basis for re-examining and redesigning operations to further improve both quality and efficiency. Two years into HSFR, this article outlines Mount Sinai Hospital's approach and highlights key lessons learned. Copyright © 2014 Longwoods Publishing.

Optimal design of high damping force engine mount featuring MR valve structure with both annular and radial flow paths

International Nuclear Information System (INIS)

Nguyen, Q H; Choi, S B; Lee, Y S; Han, M S

2013-01-01

This paper focuses on the optimal design of a compact and high damping force engine mount featuring magnetorheological fluid (MRF). In the mount, a MR valve structure with both annular and radial flows is employed to generate a high damping force. First, the configuration and working principle of the proposed MR mount is introduced. The MRF flows in the mount are then analyzed and the governing equations of the MR mount are derived based on the Bingham plastic behavior of the MRF. An optimal design of the MR mount is then performed to find the optimal structure of the MR valve to generate a maximum damping force with certain design constraints. In addition, the gap size of MRF ducts is empirically chosen considering the ‘lockup’ problem of the mount at high frequency. Performance of the optimized MR mount is then evaluated based on finite element analysis and discussions on performance results of the optimized MR mount are given. The effectiveness of the proposed MR engine mount is demonstrated via computer simulation by presenting damping force and power consumption. (paper)

Optimal design of high damping force engine mount featuring MR valve structure with both annular and radial flow paths

Science.gov (United States)

Nguyen, Q. H.; Choi, S. B.; Lee, Y. S.; Han, M. S.

2013-11-01

This paper focuses on the optimal design of a compact and high damping force engine mount featuring magnetorheological fluid (MRF). In the mount, a MR valve structure with both annular and radial flows is employed to generate a high damping force. First, the configuration and working principle of the proposed MR mount is introduced. The MRF flows in the mount are then analyzed and the governing equations of the MR mount are derived based on the Bingham plastic behavior of the MRF. An optimal design of the MR mount is then performed to find the optimal structure of the MR valve to generate a maximum damping force with certain design constraints. In addition, the gap size of MRF ducts is empirically chosen considering the ‘lockup’ problem of the mount at high frequency. Performance of the optimized MR mount is then evaluated based on finite element analysis and discussions on performance results of the optimized MR mount are given. The effectiveness of the proposed MR engine mount is demonstrated via computer simulation by presenting damping force and power consumption.

76 FR 2370 - Mount Storm Hydro, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

Science.gov (United States)

2011-01-13

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 13863-000] Mount Storm..., Motions To Intervene, and Competing Applications January 6, 2011. On October 14, 2010, Mount Storm Hydro... (FPA), proposing to study the feasibility of the Mount Storm Pumped Storage Project to be located near...

A vehicle mounted scintillation ratemeter for environmental survey

International Nuclear Information System (INIS)

Cavell, I.W.

1960-01-01

An improved method of mounting an existing environmental gamma survey equipment in a vehicle is described. Performance data for the equipment is given and some typical radiometric traces obtained at A.E.E. Winfrith given. (author)

How Mount Stromlo Observatory shed its imperial beginnings

Science.gov (United States)

Bhathal, Ragbir

2014-12-01

In the 90 years since its foundation in 1924, Mount Stromlo Observatory in Australia has changed from an outpost of empire to an international research institution. Ragbir Bhathal examines how the British influence waxed and waned.

Receptores tipo Toll, patogénesis y respuesta inmune a Helicobacter pylori Toll-like receptors, pathogenesis and immune response to Helicobacter pylori

Directory of Open Access Journals (Sweden)

Norma Angélica Sánchez-Zauco

2010-10-01

Full Text Available Helicobacter pylori coloniza el epitelio gástrico y la mayoría de las personas infectadas es asintomática, de 10 al 20% desarrolla gastritis atrófica, úlcera péptica, y menos de 3% genera cáncer gástrico. Estas patologías están determinadas por la relación entre los factores de virulencia de la bacteria y los factores del hospedero como predisposición genética y respuesta inmune. La inmunidad innata, representada principalmente por los receptores tipo Toll y tipo Nod, reconocen a sus ligandos específicos y activan factores de transcripción como NF-kB, AP-1, CREB-1, induciendo la producción de citocinas inflamatorias como IL-8, IL-12, IL-6, IL-1β, IL-18 y TNF-α, e IL-10. La inflamación crónica favorece los cambios de morfología gástrica, evita la apoptosis y favorece la angiogénesis, ocasionando lesiones neoplásicas y cáncer. El objetivo de esta revisión es analizar los mecanismos propuestos a la fecha de la respuesta inmune innata y adaptativa, involucrados en la infección por H. pylori, y se puntualiza en los mecanismos de eliminación o persistencia de la infección.Helicobacter pylori colonize the gastric epithelial, most infected people are asymptomatic, 10 to 20% develop atrophic gastritis, peptic ulcer and less than 3% gastric cancer. These diseases are determined by the relationship between virulence factors of bacteria, host factors such as, genetic predisposition, and immune response. The innate immune response mainly represented by Toll-like receptors and Nod-like receptors that recognize their specific ligands, activate transcription factors as NF-kB, AP-1, CREB-1, inducing production of inflammatory cytokines such as IL -8, IL-12, IL-6, IL-1β, IL-18, TNF-α and IL-10. Chronic inflammation promotes gastric morphological changes, prevents apoptosis and allows angiogenesis generating neoplasic lesions and cancer. The aim of this review is to analyze the mechanisms proposed to date of the innate and adaptative

The research on a novel type of the solar-blind UV head-mounted displays

Science.gov (United States)

Zhao, Shun-long

2011-08-01

Ultraviolet technology of detecting is playing a more and more important role in the field of civil application, especially in the corona discharge detection, in modern society. Now the UV imaging detector is one of the most important equipments in power equipment flaws detection. And the modern head-mounted displays (HMDs) have shown the applications in the fields of military, industry production, medical treatment, entertainment, 3D visualization, education and training. We applied the system of head-mounted displays to the UV image detection, and a novel type of head-mounted displays is presented: the solar-blind UV head-mounted displays. And the structure is given. By the solar-blind UV head-mounted displays, a real-time, isometric and visible image of the corona discharge is correctly displayed upon the background scene where it exists. The user will see the visible image of the corona discharge on the real scene rather than on a small screen. Then the user can easily find out the power equipment flaws and repair them. Compared with the traditional UV imaging detector, the introducing of the HMDs simplifies the structure of the whole system. The original visible spectrum optical system is replaced by the eye in the solar-blind UV head-mounted displays. And the optical image fusion technology would be used rather than the digital image fusion system which is necessary in traditional UV imaging detector. That means the visible spectrum optical system and digital image fusion system are not necessary. This makes the whole system cheaper than the traditional UV imaging detector. Another advantage of the solar-blind UV head-mounted displays is that the two hands of user will be free. So while observing the corona discharge the user can do some things about it. Therefore the solar-blind UV head-mounted displays can make the corona discharge expose itself to the user in a better way, and it will play an important role in corona detection in the future.

Tackling the challenges of fully immersive head-mounted AR devices

Science.gov (United States)

Singer, Wolfgang; Hillenbrand, Matthias; Münz, Holger

2017-11-01

The optical requirements of fully immersive head mounted AR devices are inherently determined by the human visual system. The etendue of the visual system is large. As a consequence, the requirements for fully immersive head-mounted AR devices exceeds almost any high end optical system. Two promising solutions to achieve the large etendue and their challenges are discussed. Head-mounted augmented reality devices have been developed for decades - mostly for application within aircrafts and in combination with a heavy and bulky helmet. The established head-up displays for applications within automotive vehicles typically utilize similar techniques. Recently, there is the vision of eyeglasses with included augmentation, offering a large field of view, and being unobtrusively all-day wearable. There seems to be no simple solution to reach the functional performance requirements. Known technical solutions paths seem to be a dead-end, and some seem to offer promising perspectives, however with severe limitations. As an alternative, unobtrusively all-day wearable devices with a significantly smaller field of view are already possible.

The Observatory as Laboratory: Spectral Analysis at Mount Wilson Observatory

Science.gov (United States)

Brashear, Ronald

2018-01-01

This paper will discuss the seminal changes in astronomical research practices made at the Mount Wilson Observatory in the early twentieth century by George Ellery Hale and his staff. Hale’s desire to set the agenda for solar and stellar astronomical research is often described in terms of his new telescopes, primarily the solar tower observatories and the 60- and 100-inch telescopes on Mount Wilson. This paper will focus more on the ancillary but no less critical parts of Hale’s research mission: the establishment of associated “physical” laboratories as part of the observatory complex where observational spectral data could be quickly compared with spectra obtained using specialized laboratory equipment. Hale built a spectroscopic laboratory on the mountain and a more elaborate physical laboratory in Pasadena and staffed it with highly trained physicists, not classically trained astronomers. The success of Hale’s vision for an astronomical observatory quickly made the Carnegie Institution’s Mount Wilson Observatory one of the most important astrophysical research centers in the world.

Mounting of Biomaterials for Use in Ophthalmic Cell Therapies.

Science.gov (United States)

Harkin, Damien G; Dunphy, Siobhan E; Shadforth, Audra M A; Dawson, Rebecca A; Walshe, Jennifer; Zakaria, Nadia

2017-11-01

When used as scaffolds for cell therapies, biomaterials often present basic handling and logistical problems for scientists and surgeons alike. The quest for an appropriate mounting device for biomaterials is therefore a significant and common problem. In this review, we provide a detailed overview of the factors to consider when choosing an appropriate mounting device including those experienced during cell culture, quality assurance, and surgery. By way of example, we draw upon our combined experience in developing epithelial cell therapies for the treatment of eye diseases. We discuss commercially available options for achieving required goals and provide a detailed analysis of 4 experimental designs developed within our respective laboratories in Australia, the United Kingdom, and Belgium.

Siting study for small platform-mounted industrial energy reactors

International Nuclear Information System (INIS)

1975-07-01

Utilizing an existing 313 MW(t) ship propulsion reactor design, a concept has been formulated for a floating platform-mounted nuclear plant and an evaluation has been made to determine reductions in construction time and cost achievable by repetitive platform construction in a shipyard. Concepts and estimates are presented for siting platform-mounted nuclear plants at the location of industrial facilities where the nuclear plants would furnish industrial process heat and/or electrical power. The representative industrial site designated for this study is considered typical of sites that might be used along the extensive network of navigable canals adjacent to the ocean and is similar to potential sites along the inland waterways of the United States

A concept of active mount for space applications

Science.gov (United States)

Souleille, A.; Lampert, T.; Lafarga, V.; Hellegouarch, S.; Rondineau, A.; Rodrigues, G.; Collette, C.

2018-06-01

Sensitive payloads mounted on top of launchers are subjected to many sources of disturbances during the flight. The most severe dynamic loads arise from the ignition of the motors, gusts, pressure fluctuations in the booster and from the separation of the boosters. The transmission of these dynamic forces can be reduced by mounting payloads on passive isolators, which comes at the expense of harmful amplifications of the motion at low frequency due to suspension resonances. To bypass this shortcoming, this paper presents a novel concept of active mount for aerospace payloads, which is easy to install, and meets two objectives. The first one is a high damping authority on both suspension resonances and flexible resonances without compromising the isolation and large stability margins of the closed loop system due to the collocation of the actuator and the sensor. The second one is a broadband reduction of the dynamic force transmitted to the payload, which was achieved in terms of 16 dB. The concept is presented in the first part of the paper and studied numerically and experimentally on a single degree of freedom isolator. A commercial isolator has been chosen for the purpose of the demonstration. The second part of the paper is dedicated to experimental validations on multi-degree of freedom scaled test benches. It is shown that the force feedback allows damping of both suspension and flexible modes (first and second modes, respectively), and significantly reducing the force transmitted in some broad frequency ranges.

A concept of active mount for space applications

Science.gov (United States)

Souleille, A.; Lampert, T.; Lafarga, V.; Hellegouarch, S.; Rondineau, A.; Rodrigues, G.; Collette, C.

2017-10-01

Sensitive payloads mounted on top of launchers are subjected to many sources of disturbances during the flight. The most severe dynamic loads arise from the ignition of the motors, gusts, pressure fluctuations in the booster and from the separation of the boosters. The transmission of these dynamic forces can be reduced by mounting payloads on passive isolators, which comes at the expense of harmful amplifications of the motion at low frequency due to suspension resonances. To bypass this shortcoming, this paper presents a novel concept of active mount for aerospace payloads, which is easy to install, and meets two objectives. The first one is a high damping authority on both suspension resonances and flexible resonances without compromising the isolation and large stability margins of the closed loop system due to the collocation of the actuator and the sensor. The second one is a broadband reduction of the dynamic force transmitted to the payload, which was achieved in terms of 16 dB. The concept is presented in the first part of the paper and studied numerically and experimentally on a single degree of freedom isolator. A commercial isolator has been chosen for the purpose of the demonstration. The second part of the paper is dedicated to experimental validations on multi-degree of freedom scaled test benches. It is shown that the force feedback allows damping of both suspension and flexible modes (first and second modes, respectively), and significantly reducing the force transmitted in some broad frequency ranges.

Clinical application of a modern high-definition head-mounted display in sonography.

Science.gov (United States)

Takeshita, Hideki; Kihara, Kazunori; Yoshida, Soichiro; Higuchi, Saori; Ito, Masaya; Nakanishi, Yasukazu; Kijima, Toshiki; Ishioka, Junichiro; Matsuoka, Yoh; Numao, Noboru; Saito, Kazutaka; Fujii, Yasuhisa

2014-08-01

Because of the remarkably improved image quality and wearability of modern head-mounted displays, a monitoring system using a head-mounted display rather than a fixed-site monitor for sonographic scanning has the potential to improve the diagnostic performance and lessen the examiner's physical burden during a sonographic examination. In a preclinical setting, 2 head-mounted displays, the HMZ-T2 (Sony Corporation, Tokyo, Japan) and the Wrap1200 (Vuzix Corporation, Rochester, NY), were found to be applicable to sonography. In a clinical setting, the feasibility of the HMZ-T2 was shown by its good image quality and acceptable wearability. This modern device is appropriate for clinical use in sonography. © 2014 by the American Institute of Ultrasound in Medicine.

Exploring children's understanding of death: through drawings and the Death Concept Questionnaire.

Science.gov (United States)

Bonoti, Fotini; Leondari, Angeliki; Mastora, Adelais

2013-01-01

To investigate whether children's understanding of the concept of death varies as a function of death experience and age, 52 children aged 7, 9, and 11 years (26 had a personal death experience), drew a picture reflecting the meaning of the word death and completed the Death Concept Questionnaire for examination of Human and Animal Death. The results showed that the 2 methodological tools used offered complementary information and that children's understanding of death is related both to age and past experience. Children with death experience seem to have a more realistic understanding of death than their inexperienced age-mates. As regards to the effect of age, our findings support the assumption that the different components of death develop through different processes.

Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma

NARCIS (Netherlands)

Kerkhof, M.; Postma, D. S.; Brunekreef, B.; Reijmerink, N. E.; Wijga, A. H.; de Jongste, J. C.; Gehring, U.; Koppelman, G. H.

Background Epidemiological studies have reported adverse effects of ambient air pollution on the prevalence of asthma. Laboratory studies have suggested that innate immune responses are involved. Objective A study was undertaken to determine whether the Toll-like receptor 2 and 4 genes (TLR2 and

Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators

NARCIS (Netherlands)

Rachmawati, D.; Bontkes, H.J.; Verstege, M.I.; Muris, J.; von Blomberg, B.M.E.; Scheper, R.J.; van Hoogstraten, I.M.W.

2013-01-01

Background Nickel was recently identified as a potent activator of dendritic cells through ligating with human Toll-like receptor (TLR)-4. Objectives Here, we studied an extended panel of transition metals neighbouring nickel in the periodic table of elements, for their capacity to activate human

Life on Mount Obstacle: Disease of existence as condition and possibility

DEFF Research Database (Denmark)

Aggerholm, Kenneth; Jespersen, Ejgil

will analyze various kinds of human meaning that can be found on Mount Obstacle, departing from two key positions: First, Camus (1967) used The Myth of Sisyphus to describe how the experience of obstacles is a human condition. In cases of disability this condition is of course more evident, but the task...... is still to create meaning from this absurd condition. Sisyphus is to Camus an ’absurd hero’ because he is aware of and acknowledges the challenge that he is condemned to. This means that the struggle to overcome the necessary obstacle can become a meaningful pursuit, wherefore Camus concluded: ”The...... be illustrated by Suits’ (2005) classical treatise on game playing. By choosing to climb Mount Obstacle the activity of climbing becomes an end in itself, which opens for experiencing the intrinsic value related to voluntarily attempting to overcome the unnecessary obstacle. In both cases life on Mount Obstacle...

Polymorphism N248S in the Human Toll-Like Receptor 1 Gene Is Related to Leprosy and Leprosy Reactions

NARCIS (Netherlands)

Schuring, Ron P.; Hamann, Lutz; Faber, William R.; Pahan, David; Richardus, Jan Hendrik; Schumann, Ralf R.; Oskam, Linda

2009-01-01

We investigated the association between a polymorphism of a key innate immunity receptor, Toll-like receptor 1 (TLR1) N248S, and susceptibility to leprosy and its clinical presentation. TLR1 N248S has been shown elsewhere to diminish TLR1 signaling and subsequent leprosy disease. The homozygous

Energetic and developmental costs of mounting an immune response in greenfinches (Carduelis chloris)

NARCIS (Netherlands)

Amat, Juan A.; Aguilera, Eduardo; Visser, G. Henk

It is assumed that there is a trade-off between the costs allocated to mounting an immune defence and those allocated to costly functions such as breeding and moulting. The physiological basis for this is that mounting an immune response to pathogen challenge has energetic and/or nutrient costs

Mapping the Spread of Mounted Warfare

Directory of Open Access Journals (Sweden)

Peter Turchin

2016-12-01

Full Text Available Military technology is one of the most important factors affecting the evolution of complex societies. In particular, mounted warfare, the use of horse-riders in military operations, revolutionized war as it spread to different parts of Eurasia and Africa during the Ancient and Medieval eras, and to the Americas during the Early Modern period. Here we use a variety of sources to map this spread.

New mounting improves solar-cell efficiency

Science.gov (United States)

Shepard, N. F., Jr.

1980-01-01

Method boosts output by about 20 percent by trapping and redirecting solar radiation without increasing module depth. Mounted solar-cell array is covered with internally reflecting plate. Plate is attached to each cell by transparent adhesive, and space between cells is covered with layer of diffusely reflecting material. Solar energy falling on space between cells is diffused and reflected internally by plate until it is reflected onto solar cell.

Two faces of death: fatalities from disease and combat in America's principal wars, 1775 to present.

Science.gov (United States)

Cirillo, Vincent J

2008-01-01

Throughout America's first 145 years of war, far more of the country's military personnel perished from infectious diseases than from enemy action. This enduring feature of war was finally reversed in World War II, chiefly as a result of major medical advances in prevention (vaccines) and treatment (antibiotics). Safeguarding the health of a command is indispensable for the success of any campaign. Wars are lost by disease, which causes an enormous drain on the military's resources and affects both strategy and tactics. Disease and combat mortality data from America's principal wars (1775-present) fall into two clearly defined time periods: the Disease Era (1775-1918), during which infectious diseases were the major killer of America's armed forces, and the Trauma Era (1941-present), in which combat-related fatalities predominated. The trend established in World War II continues to the present day. Although there are currently more than 3,400 U.S. military fatalities in Iraq, the disease-death toll is so low that it is exceeded by the number of suicides.

Shaded Relief with Height as Color, Mount Meru, Tanzania

Science.gov (United States)

2002-01-01

Mount Meru is an active volcano located just 70 kilometers (44 miles) west of Mount Kilimanjaro. It reaches 4,566 meters (14,978 feet) in height but has lost much of its bulk due to an eastward volcanic blast sometime in its distant past, perhaps similar to the eruption of Mount Saint Helens in Washington State in 1980. Mount Meru most recently had a minor eruption about a century ago. The several small cones and craters seen in the vicinity probably reflect numerous episodes of volcanic activity. Mount Meru is the topographic centerpiece of Arusha National Park. Its fertile slopes rise above the surrounding savanna and support a forest that hosts diverse wildlife, including nearly 400 species of birds, and also monkeys and leopards.Two visualization methods were combined to produce this image: shading and color coding of topographic height. The shade image was derived by computing topographic slope in the north-south direction. Northern slopes appear bright and southern slopes appear dark, as would be the case at noon at this latitude in June. Color coding is directly related to topographic height, with green at the lower elevations, rising through yellow, red, and magenta, to blue and white at the highest elevations.Elevation data used in this image was acquired by the Shuttle Radar Topography Mission (SRTM) aboard the Space Shuttle Endeavour, launched on Feb. 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect 3-D measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter (approximately 200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between NASA, the National Imagery and Mapping Agency (NIMA) of the U.S. Department of Defense and the German and Italian space

Redefining Death

Institute of Scientific and Technical Information of China (English)

2009-01-01

The results of 20 years of research on brain death will be released to the public, the Chinese Ministry of Health reported in early April. A special ministry team has drafted the criteria for brain death in Criteria for the Diagnosis of Brain Death in Adults (Revised Edition) and Technical Specifications for the Diagnosis

Toll-like receptors of deuterostome invertebrates

Directory of Open Access Journals (Sweden)

Honoo eSatake

2012-02-01

Full Text Available Defensive systems against pathogens are responsible not only for survival or lifetime of an individual but also for the evolution of a species. Innate immunity is expected to be more important for invertebrates than mammals, given that adaptive immunity has not been acquired in the former. Toll-like receptors (TLRs have been shown to play a crucial role in host defense of pathogenic microbes in innate immunity of mammals. Recent genome-wide analyses have suggested that TLR or their related genes are conserved in invertebrates. In particular, numerous TLR-related gene candidates were detected in deuterostome invertebrates including a sea urchin (222 TLR-related gene candidates and amphioxus (72 TLR-related gene candidates. Molecular phylogenetic analysis verified that most of sea urchin or amphioxus TLR candidates are paralogous, suggesting that these organisms expanded TLR-related genes in a species-specific manner. In contrast, another deuterostome invertebrate, an ascidian, Ciona intestinalis, was found to possess only two TLR genes. Moreover, Ciona TLRs, Ci-TLR1 and -2, were shown to possess hybrid functionality of mammalian TLRs. Such functionality of Ci-TLRs could not be predicted by sequence comparison with vertebrate TLRs, indicating the confounding evolutionary lineages of deuterostome invertebrate TLRs or their candidates. In this review article, we present recent advances in studies of TLRs or their candidates of deuterostome invertebrates, and provide insight into an evolutionary process of TLRs.

ATST telescope mount: telescope of machine tool

Science.gov (United States)

Jeffers, Paul; Stolz, Günter; Bonomi, Giovanni; Dreyer, Oliver; Kärcher, Hans

2012-09-01

The Advanced Technology Solar Telescope (ATST) will be the largest solar telescope in the world, and will be able to provide the sharpest views ever taken of the solar surface. The telescope has a 4m aperture primary mirror, however due to the off axis nature of the optical layout, the telescope mount has proportions similar to an 8 meter class telescope. The technology normally used in this class of telescope is well understood in the telescope community and has been successfully implemented in numerous projects. The world of large machine tools has developed in a separate realm with similar levels of performance requirement but different boundary conditions. In addition the competitive nature of private industry has encouraged development and usage of more cost effective solutions both in initial capital cost and thru-life operating cost. Telescope mounts move relatively slowly with requirements for high stability under external environmental influences such as wind buffeting. Large machine tools operate under high speed requirements coupled with high application of force through the machine but with little or no external environmental influences. The benefits of these parallel development paths and the ATST system requirements are being combined in the ATST Telescope Mount Assembly (TMA). The process of balancing the system requirements with new technologies is based on the experience of the ATST project team, Ingersoll Machine Tools who are the main contractor for the TMA and MT Mechatronics who are their design subcontractors. This paper highlights a number of these proven technologies from the commercially driven machine tool world that are being introduced to the TMA design. Also the challenges of integrating and ensuring that the differences in application requirements are accounted for in the design are discussed.

[Ill-defined causes of death and unattended deaths, Brazil, 2003].

Science.gov (United States)

Santo, Augusto Hasiak

2008-01-01

We studied the distribution of deaths from ill-defined causes that occurred in Brazil during 2003, from which was identified the proportion of unattended deaths. Data were obtained from the Mortality Information System, coordinated by the Ministry of Health. Causes of death included in "Chapter XVIII - Symptoms, signs and abnormal clinical and laboratory findings, not classified elsewhere" of the International Statistical Classification of Diseases and Related Health Problems, tenth revision, were considered ill-defined, among which the category R98 identified "unattended deaths". In Brazil during 2003 the underlying causes of 13.3% of deaths were included in the Chapter of ill-defined causes, and the highest proportions of these deaths occurred in the Northeast and North Regions. Considering the total deaths from ill-defined causes, 53 % correspond to unattended deaths. This proportion increased to over 70% in the states of Maranhão, Piauí, Rio Grande do Norte, Pernambuco, Bahia, Paraíba and Alagoas. Due to the decentralized structure of data collection in the country, we believe that the municipalities bear the major responsibility, followed by the states, for upgrading the quality of mortality statistics.

Plasma membrane Toll-like receptor activation increases bacterial uptake but abrogates endosomal Lactobacillus acidophilus induction of interferon-β

DEFF Research Database (Denmark)

Boye, Louise; Welsby, Iain; Lund, Lisbeth Drozd

2016-01-01

Lactobacillus acidophilus induces a potent interferon-β (IFN-β) response in dendritic cells (DCs) by a Toll-like receptor 2 (TLR2) -dependent mechanism, in turn leading to strong interleukin-12 (IL-12) production. In the present study, we investigated the involvement of different types of endocyt...

Influence of social mixing and group size on skin lesions and mounting in organic entire male pigs

DEFF Research Database (Denmark)

Thomsen, Rikke; Edwards, Sandra A; Rousing, Tine

2016-01-01

in management procedures and production system might be needed. Elements from the organic pig production system might be beneficial in this aspect. The aim of this article is to investigate the effect of grouping strategy including social mixing and group size on levels of mounting behaviour and skin lesions...... at weaning. A second mixing occurred at insertion to fattening pens for pigs being regrouped. Counting of skin lesions (1348 or 1124 pigs) and registration of mounting behaviour (1434 or 1258 pigs) were done on two occasions during the experimental period. No interactive effects were found between social...... mixing and group size on either skin lesions or mounting frequency. Herd differences were found for both mounting frequency and number of skin lesions. No association between skin lesions and mounting were revealed. Social mixing and group size were shown as interacting effects with herds on mounting...

Experience with HEP analysis on mounted filesystems

International Nuclear Information System (INIS)

Fuhrmann, Patrick; Gasthuber, Martin; Kemp, Yves; Ozerov, Dmitry

2012-01-01

We present results on different approaches on mounted filesystems in use or under investigation at DESY. dCache, established since long as a storage system for physics data has implemented the NFS v4.1/pNFS protocol. New performance results will be shown with the most current version of the dCache server. In addition to the native usage of the mounted filesystem in a LAN environment, the results are given for the performance of the dCache NFS v4.1/pNFS in WAN case. Several commercial vendors are currently in alpha or beta phase of adding the NFS v4.1/pNFS protocol to their storage appliances. We will test some of these vendor solutions for their readiness for HEP analysis. DESY has recently purchased an IBM Sonas system. We will present the result of a thorough performance evaluation using the native protocols NFS (v3 or v4) and GPFS. As the emphasis is on the usability for end user analysis, we will use latest ROOT versions and current end user analysis code for benchmark scenarios.