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Sample records for daihenshin keburu pc

  1. Consideration on extradosed prestressed concrete road bridge; Dorokyo ni okeru daihenshin PC keburu kyo

    Energy Technology Data Exchange (ETDEWEB)

    Ogawa, A.; Honma, A. [Japan Highway Public Corp., Tokyo (Japan)

    1997-03-31

    The details of the investigation on the Odawara Blue Way Bridge for which extradosed type is employed are provided, and a report is made about the situation of the study on the future construction of the 2nd Tomei-Meishin Expressway. The extradosed PC bridge is considered to have intermediate structural characteristics of those of the conventional beam bridge and PC cable stayed bridge, and is expected to be applied to bridges having approximately from 100 to 200m span. The features of the extradosed PC bridge is outlined. Approximately 1/35 beam height on the intermediate support and 1/10 main tower height against the center span are considered to be proper. PC steel products can be used efficiently because stress fluctuation of diagonals and the load sharing rate of the diagonal member are less than those of the PC cable stayed bridge and safety factor similar to that of general internal cable can be adopted. Construction works for the main tower and the diagonal member are easy due to low height of the main tower, and the bridge is advantageous also in the maintenance control because no beam is required. 5 refs., 8 figs., 2 tabs.

  2. Feature of extradosed PC bridge and its design; Daihenshin keburu PC kyo no tokucho to sono sekkei

    Energy Technology Data Exchange (ETDEWEB)

    Komiya, M. [Japan Bridge and Structure Institute Inc., Tokyo (Japan)

    1997-03-31

    A PC bridge with the eccentricity of the external cable increased by protruding the deviated member to the outside of the beam for more effective use of the external cable is called a `PC bridge with tendons of large eccentricity.` The extradosed bridge of main beam/cable joint type is a PC bridge with the external cable arranged via a tower-shaped eccentric member provided at the intermediate support, and resembles morphologically a cable stayed bridge having a very low tower. There are two types of extradosed bridges, i.e. a type with concrete coated external cable (cable stayed slab bridge) and the other with non-coated external cable (external cable stayed bridge). Features, structural planning and designing of the general external cable stayed bridge are shown. The features are the possession of intermediate characteristics of those of the PC beam bridge and the PC cable stayed bridge from the viewpoints of structural property, workability, economic efficiency, and scenic property. Outline of the plan, selection of structural data, design of the external cable, and structural characteristics in the ultimate state are discussed. 19 refs., 18 figs., 15 tabs.

  3. Wind-induced cable vibrations and countermeasures of cables of PC cable-stayed bridge. PC syachokyo keburu no kaze ni yoru shindo to sono taisaku

    Energy Technology Data Exchange (ETDEWEB)

    Yoneda, M. (Kawada Industries Inc., Tokyo (Japan))

    1994-05-01

    In recent years, long span of cable-stayed bridges is remarkable. The wind-induced cable vibration called as line vibration and wake galloping was given as an important problem not only in the steel cable-stayed bridges but also in the PC cable-stayed bridges. The technical engineers in design of the cable-stayed bridges have many times to confront the problems on the vibration control of cables, it is considered that sufficient understand of the wind-induced vibration and countermeasures for cables of the PC cable-stayed bridges is necessary. Many reports on the countermeasure examples and trend of vibration control centred on cables of the cable-stayed bridges have been published. In this paper, the wind-induced vibration of cables in the cable-stayed bridges was reviewed, the examples of countermeasures of vibration control on cables in the PC cable-stayed bridges was mainly introduced. The remaining tasks and future prospects on vibration control of the PC cable-stayed bridges were described. 14 refs., 13 figs., 4 tabs.

  4. Control means of the aerodynamic vibration occured in Parallel of PC cable-stayed bridge; PC shachokyo heiretsu keburu no taifu seishin taisaku to sono koka

    Energy Technology Data Exchange (ETDEWEB)

    Sato, H. [Public Works Research Inst., Tsukuba (Japan); Takeda, T.; Mukai, H. [Kajima Corp., Tokyo (Japan); Oikawa, K. [SE Corp., Tokyo (Japan)

    1996-01-30

    In recent years, the techniques for the typical PC bridges shown in the title have been considerably developed in Japan. However, occurrence of characteristic vibrations of the parallel cables even at relatively low wind speeds are observed in many cases, for which an effective control means is inevitably required. In this report, an investigation of tests on effectiveness of 4 kinds of vibration control means carried out in a wind tunnel and its results are described. In the test, an elastic model of 3-dimension was used for 5 test cases including a case without any control means, and each case was explained and examined in detail. It was revealed that for a damping system, a considerably large damping effect was necessary to restraint the wake galloping, and the cable distance selected to be 1.5 times smaller or 6 times larger than the cable diameter was effective, and while vibration control wires were effective, the adjustment of the cable vibration frequency was ineffective. It was also pointed out that a further verification would be necessary for the latter 2 control systems as no enough experience was yet accumulated in the actual service. 13 refs., 16 figs., 6 tabs.

  5. PC communication

    International Nuclear Information System (INIS)

    Oh, Jae Cheol

    1992-03-01

    This text book is comprised of five charters, which is about PC communication for beginners who need to learn manners and how to use Ketel and PC serve. So it introduces first, conception of PC and precautions on using PC communication, second, preparation for PC communication with Modem, its program, install, kinds of protocol and how to use protocol, third directions of emulator of PC communication and super session, fourth, instruction of Ketel with join and access, basic command of Ketel, list of Ketel's menu, Ketel editor, service guide, directions of News service, Stock and bond service business and economic figures, exchange rate and interest rate, tax culture and leisure, Ketel BBS service and posting. The last part has a instruction of PC-serve about join, basic command of PC-serve, service guide and practical guideline.

  6. PC communication

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Jae Cheol

    1992-03-15

    This text book is comprised of five charters, which is about PC communication for beginners who need to learn manners and how to use Ketel and PC serve. So it introduces first, conception of PC and precautions on using PC communication, second, preparation for PC communication with Modem, its program, install, kinds of protocol and how to use protocol, third directions of emulator of PC communication and super session, fourth, instruction of Ketel with join and access, basic command of Ketel, list of Ketel's menu, Ketel editor, service guide, directions of News service, Stock and bond service business and economic figures, exchange rate and interest rate, tax culture and leisure, Ketel BBS service and posting. The last part has a instruction of PC-serve about join, basic command of PC-serve, service guide and practical guideline.

  7. PC Pricer

    Data.gov (United States)

    U.S. Department of Health & Human Services — The PC Pricer is a tool used to estimate Medicare PPS payments. The final payment may not be precise to how payments are determined in the Medicare claims processing...

  8. Biomimicry 1: PC.

    Science.gov (United States)

    Cumberland, D C; Gunn, J; Malik, N; Holt, C M

    1998-01-01

    The surface properties of stents can be modified by coating them, for example with a polymer. Phosphorylcoline (PC) is the major component of the outer layer of the cell membrane. The haemo- and biocompatibility of a PC-containing polymer is thus based on biomimicry, and has been confirmed by several experiments showing much reduced thrombogenicity of PC-coated surfaces, and porcine coronary artery implants showing no sign of adverse effect. Clinical experience with the PC-coated BiodivYsio appears favourable. The PC coating can be tailored for take up and controlled elution of various drugs for stent-based local delivery, a property which is being actively explored.

  9. PC-BLAS, PC Linear Algebra Subroutines

    International Nuclear Information System (INIS)

    Hanson, R.J.

    1989-01-01

    1 - Description of program or function: PC-BLAS is a highly optimized version of the Basic Linear Algebra Subprograms (BLAS), a standardized set of 38 routines that perform low-level operations on vectors of numbers in single- and double-precision real and complex arithmetic. Routines are included to find the index of the largest component of a vector, apply a Givens or modified Givens rotation, multiply a vector by a constant, determine the Euclidean length, perform a dot product, swap and copy vectors, and find the norm of a vector. 2 - Restrictions on the complexity of the problem: The number of components in any vector and the spacing or stride between their entries must not exceed 32,767 (2 15 -1). PC-BLAS will not work with an 80286 CPU operating in 'protected' mode

  10. PC clusters at CERN's PC farm

    CERN Multimedia

    Patrice Loïez

    2001-01-01

    These Linux-based PC clusters are mainly used for batch and interactive data processing. When the LHC starts operation in 2008, it will produce enough data every year to fill a stack of CDS 20 km tall, so high quality processing is required. To further facilitate this the LHC Computing Grid (LCG) has been set up to share processing power between facilities around the world.

  11. The PC graphics handbook

    CERN Document Server

    Sanchez, Julio

    2003-01-01

    Part I - Graphics Fundamentals PC GRAPHICS OVERVIEW History and Evolution Short History of PC Video PS/2 Video Systems SuperVGA Graphics Coprocessors and Accelerators Graphics Applications State-of-the-Art in PC Graphics 3D Application Programming Interfaces POLYGONAL MODELING Vector and Raster Data Coordinate Systems Modeling with Polygons IMAGE TRANSFORMATIONS Matrix-based Representations Matrix Arithmetic 3D Transformations PROGRAMMING MATRIX TRANSFORMATIONS Numeric Data in Matrix Form Array Processing PROJECTIONS AND RENDERING Perspective The Rendering Pipeline LIGHTING AND SHADING Lightin

  12. Leo II PC

    Data.gov (United States)

    Kansas Data Access and Support Center — LEO II is a second-generation software system developed for use on the PC, which is designed to convert location references accurately between legal descriptions and...

  13. Building the perfect PC

    CERN Document Server

    Thompson, Robert Bruce

    2006-01-01

    This popular Build-It-Yourself (BIY) PC book covers everything you want to know about building your own system: Planning and picking out the right components, step-by-step instructions for assembling your perfect PC, and an insightful discussion of why you'd want to do it in the first place. Most big brand computers from HP, Dell and others use lower-quality components so they can meet their aggressive pricing targets. But component manufacturers also make high-quality parts that you can either purchase directly, or obtain through distributors and resellers. Consumers and corporations

  14. PC Scene Generation

    Science.gov (United States)

    Buford, James A., Jr.; Cosby, David; Bunfield, Dennis H.; Mayhall, Anthony J.; Trimble, Darian E.

    2007-04-01

    AMRDEC has successfully tested hardware and software for Real-Time Scene Generation for IR and SAL Sensors on COTS PC based hardware and video cards. AMRDEC personnel worked with nVidia and Concurrent Computer Corporation to develop a Scene Generation system capable of frame rates of at least 120Hz while frame locked to an external source (such as a missile seeker) with no dropped frames. Latency measurements and image validation were performed using COTS and in-house developed hardware and software. Software for the Scene Generation system was developed using OpenSceneGraph.

  15. ORPLOT.PC: a graphic utility for ORMGEN.PC and ORVIRT.PC

    International Nuclear Information System (INIS)

    Inversini, C.; Bryson, J.W.

    1986-06-01

    ORPLOT.PC is an interactive graphic utility for ORMGEN.PC and ORVIRT.PC. It executes on an IBM PC/XT or PC/AT equipped with hard disk, graphic card, and 512K minimum memory. The program is capable of: (1) displaying finite-element meshes generated by ORMGEN.PC complete with node numbers, element numbers, and boundary conditions; and (2) generating deformed mesh plots, contour plots, line (X-Y) plots, and developed surface plots of ORVIRT.PC output. A zooming feature allows detailed inspection of any subregion. Because simplicity and ease of use were important objectives during program development, all commands are entered interactively using free format. The option of automatic or user-defined scaling for most plots is another convenience. Plot files may be created and written to hard disk for subsequent hardcopy to printer or plotter. 2 refs., 7 figs

  16. 76 FR 5467 - Airworthiness Directives; Pilatus Aircraft Ltd. Models PC-6, PC-6-H1, PC-6-H2, PC-6/350, PC-6/350...

    Science.gov (United States)

    2011-02-01

    ...;Prices of new books are listed in the first FEDERAL REGISTER issue of each #0;week. #0; #0; #0; #0;#0..., Fairchild Heli Porter PC-6 airplanes, or Fairchild-Hiller Corporation PC-6 airplanes. Discussion Section... [[Page 5469

  17. Repairing and Upgrading Your PC

    CERN Document Server

    Thompson, Robert

    2009-01-01

    Repairing and Upgrading Your PC delivers start-to-finish instructions, simple enough for even the most inexperienced PC owner, for troubleshooting, repairing, and upgrading your computer. Written by hardware experts Robert Bruce Thompson and Barbara Fritchman Thompson, this book covers it all: how to troubleshoot a troublesome PC, how to identify which components make sense for an upgrade, and how to tear it all down and put it back together. This book shows how to repair and upgrade all of your PC's essential components.

  18. ELIPGRID-PC: Upgraded version

    International Nuclear Information System (INIS)

    Davidson, J.R.

    1995-12-01

    Evaluating the need for and the effectiveness of remedial cleanup at waste sites often includes finding average contaminant concentrations and identifying pockets of contamination called hot spots. The standard tool for calculating the probability of detecting pockets of contamination called hot spots has been the ELIPGRID code of singer and Wickman. The ELIPGRID-PC program has recently made this algorithm available for an IBM reg-sign personal computer (PC) or compatible. A new version of ELIPGRID-PC, incorporating Monte Carlo test results and simple graphics, is herein described. Various examples of how to use the program for both single and multiple hot spot cases are given. The code for an American National Standards Institute C version of the ELIPGRID algorithm is provided, and limitations and further work are noted. This version of ELIPGRID-PC reliably meets the goal of moving Singer's ELIPGRID algorithm to the PC

  19. VIDEO-PC, SVGA Routines for FORTRAN on PC

    International Nuclear Information System (INIS)

    1994-01-01

    1 - Description of program or function: These primitives are the lowest level routines needed to perform super VGA graphics on a PC. A sample main program is included that exercises the primitives. Both Lahey and Microsoft FORTRAN's have graphics libraries. However, the libraries do not support 256 color graphics at resolutions greater than 320x200. The primitives bypass these libraries while still conforming to standard usage of BIOS. The supported graphics modes depend upon the PC graphics card and its memory. Super VGA resolutions of 640x480 and 800x600 have been tested on an ATI VGA Wonder card with 512 K memory and on several 80486 PC's (unknown manufacturers) at retail stores. 2 - Method of solution: Both Lahey and Microsoft primitives depend upon sending the correct parameters to the PC BIOS (basic input output system) as discussed in the references. 3 - Restrictions on the complexity of the problem: The primitives were developed for 256 color VGA applications. It is known, for instance, that some CGA and 16 color VGA video modes will not operate correctly using these primitives. Potential users should try the test program on their PC/video card combination to determine applicability

  20. Port virtual addressing for PC

    International Nuclear Information System (INIS)

    Bolanos, L.; Arista, E.; Osorio Deliz, J.F.

    1997-01-01

    Instruments for nuclear signal measurements based on add-on card for a personal computer (PC) are designed often. Then one faces the problem of the addressing of data input/output devices which show an integration level or intelligence that makes the use of several port address indispensable, and these are limited in the PC. The virtual addressing offers the advantage of the occupation of few addresses to accede to many of these devices. The principles of this technique and the appliances of a solution in radiometric in a radiometric card based on programmed logic are discussed in this paper

  1. Junior PC-Kørekort

    DEFF Research Database (Denmark)

    Hansbøl, Mikala; Mathiasen, Helle

    udviklingsprojekt med forsøg med DANSK IT's Junior PC-kørekort® som metode og redskab til at evaluere og dokumentere elevernes IT-kompetencer. Projektet blev gennemført i perioden fra 2002-2003 og afsluttet i foråret 2003. Rapporten er baseret på kvalitative case studier af elever og læreres arbejde med Junior PC......-kørekort® prøverne. DANSK IT's Junior PC-kørekort® kan betragtes som et forsøg på at etablere en bestemt fælleskulturel tilgang til elevernes IT-kompetencer i folkeskolen. Ud fra et situeret læringsperspektiv problematiserer rapporten anvendelsen af de standardiserede prøver som metode til at dokumentere og evaluere...... elevernes IT-kompetencer. Rapporten (2MB) fylder 80 sider ekskl. bilag. Bemærk, at forskningsrapporten handler om Dansk IT's Junior PC-kørekort - ikke at forveksle med det IT-bevis for folkeskolens elever, som Undevisningsministeriet har udviklet. Dette IT-bevis koncept skiftede navn i januar 2004, hvor...

  2. Poster session ELIPGRID-PC

    International Nuclear Information System (INIS)

    Davidson, J.R.

    1995-01-01

    ELIPGRID-PC, a new personal computer program, has been developed to provide easy access to Singer's ELIPGRID algorithm for hot-spot detection probabilities. Three features of the program are the ability to determine: (1) the grid size required for specified conditions, (2) the smallest hot spot that can be sampled with a given probability, and (3) the approximate grid size resulting from specified conditions and sampling cost. ELIPGRID-PC also provides probability of detection versus cost data for graphing with spreadsheets or graphics software. The program has been successfully tested using Singer's published ELIPGRID results. An apparent error in the published ELIPGRID code has been uncovered and an appropriate modification incorporated into the new program

  3. PC based uranium enrichment analyser

    International Nuclear Information System (INIS)

    Madan, V.K.; Gopalakrishana, K.R.; Bairi, B.R.

    1991-01-01

    It is important to measure enrichment of unirradiated nuclear fuel elements during production as a quality control measure. An IBM PC based system has recently been tested for enrichment measurements for Nuclear Fuel Complex (NFC), Hyderabad. As required by NFC, the system has ease of calibration. It is easy to switch the system from measuring enrichment of fuel elements to pellets and also automatically store the data and the results. The system uses an IBM PC plug in card to acquire data. The card incorporates programmable interval timers (8253-5). The counter/timer devices are executed by I/O mapped I/O's. A novel algorithm has been incorporated to make the system more reliable. The application software has been written in BASIC. (author). 9 refs., 1 fig

  4. El blindaje de una PC

    Directory of Open Access Journals (Sweden)

    Revista Chasqui

    2015-01-01

    Full Text Available La navegación en Internet y la consiguiente conexión a una red expone a una computadora a un sinfín de riesgos y peligros. Una PC que no sea utilizada para navegar en Internet o que no esté conectada a una red puede,incluso, ser también afectada por virus, por la utilización de disquetes contaminados que la contaminen con un virus. Para enfrentar esos problemas, la industria informática ha previsto una serie de protecciones y recaudos, de cuyo uso y utilización deben estar plenamente informados los usuarios de una PC.

  5. Data acquisition techniques using PC

    CERN Document Server

    Austerlitz, Howard

    1991-01-01

    Data Acquisition Techniques Using Personal Computers contains all the information required by a technical professional (engineer, scientist, technician) to implement a PC-based acquisition system. Including both basic tutorial information as well as some advanced topics, this work is suitable as a reference book for engineers or as a supplemental text for engineering students. It gives the reader enough understanding of the topics to implement a data acquisition system based on commercial products. A reader can alternatively learn how to custom build hardware or write his or her own software.

  6. PC based vibration monitoring system

    International Nuclear Information System (INIS)

    Jain, Sanjay K.; Roy, D.A.; Pithawa, C.K.; Patil, R.K.

    2004-01-01

    Health of large rotating machinery gets reflected in the vibration signature of the rotor and supporting structures and proper recording of these signals and their analysis can give a clear picture of the health of the machine. Using these data and their trending, it is possible to predict an impending trouble in the machine so that preventive action can be taken in time and catastrophic failure can be avoided. Continuous monitoring and analysis can give quick warning and enable operator to take preventive measures. Reactor Control Division, BARC is developing a PC based Vibration monitoring system for turbo generator machinery. The System can acquire 20 vibration signals at a rate of 5000 samples per second and also 15 process signals at a rate of 100 samples/ sec. The software for vibration monitoring system includes acquisition modules, analysis modules and Graphical User Interface module. The acquisition module involves initialization, setting of required parameters and acquiring the data from PC-based data acquisition cards. The acquired raw vibration data is then stored for analysis using various software packages. The display and analysis of acquired data is done in LabVIEW 7.0 where the data is displayed in time as well as frequency domain along with the RMS value of the signal. (author)

  7. PC driven integrated vacuum system

    International Nuclear Information System (INIS)

    Curuia, Marian; Culcer, Mihai; Brandea, Iulian; Anghel, Mihai

    2001-01-01

    The monitoring of industrial plants by virtual instrumentation represents the most modern trend in the domain of electronic equipment. The integrated vacuum system presented here has several facilities, including the automated data storing of measurement results on hard disk and providing warning messages for operators when the measured parameters are lower or higher upper than the fixed values. The system can also work stand-alone, receiving the commands from the keyboards placed on his front panel but, when it is included in a automation complex system, a remote control from PC is necessary . Both parts of the system, power supply unit for turbo-molecular pump and the vacuum gage, are controlled by an 80C31 microcontroller. Because this microcontroller has a built-in circuitry for a serial communication, we established a serial communication between the PC and the power supply unit for turbo-molecular pump and the vacuum gage, according to the RS-232 hardware standard. As software, after careful evaluation of several options, we chose to develop a hybrid software packing using two different software development tools: LabVIEW, and assembly language. We chose LabVIEW because it is dedicated to data acquisition and communications, containing libraries for data collection, analysis, display and storage. (authors)

  8. PC/104 Embedded IOCs at Jefferson Lab

    International Nuclear Information System (INIS)

    Yan, Jianxun; Allison, Trent; Witherspoon, Sue; Cuffe, Anthony

    2009-01-01

    Jefferson Lab has developed embedded IOCs based on PC/104 single board computers (SBC) for low level control systems. The PC/104 IOCs run EPICS on top of the RTEMS operating system. Two types of control system configurations are used in different applications, PC/104 SBC with commercial PC/104 I/O cards and PC/104 SBC with custom designed FPGA-based boards. RTEMS was built with CEXP shell to run on the PC/104 SBC. CEXP shell provides the function of dynamic object loading, which is similar to the widely used VxWorks operating system. Standard software configurations were setup for PC/104 IOC application development to provide a familiar format for new projects as well as ease the conversion of applications from VME based IOCs to PC/104 IOCs. Many new projects at Jefferson Lab are going to employ PC/104 SBCs as IOCs and some applications have already been running them for accelerator operations. The PC/104 - RTEMS IOC provides a free open source Real-Time Operating System (RTOS), low cost/maintenance, easily installed/ configured, flexible, and reliable solution for accelerator control and 12GeV Upgrade projects.

  9. PC-Reactor-core transient simulation code

    International Nuclear Information System (INIS)

    Nakata, H.

    1989-10-01

    PC-REATOR, a reactor core transient simulation code has been developed for the real-time operator training on a IBM-PC microcomputer. The program presents capabilities for on-line exchange of the operating parameters during the transient simulation, by friendly keyboard instructions. The model is based on the point-kinetics approximation, with 2 delayed neutron percursors and up to 11 decay power generating groups. (author) [pt

  10. Pc Card Sony Ericsson: Semiotik Dan Iklan

    OpenAIRE

    Mutmainnah, Yulia

    2014-01-01

    Through advertisement, producers send messages for their product strength to consumers. Those messages are conveyed through various kinds of signs either in the form of language, picture, caption, icon, index, or symbol. There is communicative exchange on GC79 PC Card Sony Ericsson advertisement between sender and receiver. Sender (advertisement maker) of this advertisement makes good use of reward polluter style, which is, persuading comsumers to use PC Card Sony Ericsson product.

  11. PC 11: Symbiotic star or planetary nebulae?

    International Nuclear Information System (INIS)

    Gutierrez-Moreno, A.; Moreno, H.; Cortes, G.

    1987-01-01

    PC 11 is an object listed in Perek and Kohoutek (1967) Catalogue of Galactic Planetary Nebulae as PK 331 -5 0 1. Some authors suggest that it is not a planetary nebula, but that it has some characteristics (though not all) of symbiotic stars. We have made photographic, spectrophotometric and spectroscopic observations of PC 11. The analysis of the results suggests that it is a young planetary nebula. (Author)

  12. PC based 8-parameter data acquisition system

    International Nuclear Information System (INIS)

    Gupta, J.D.; Naik, K.V.; Jain, S.K.; Pathak, R.V.; Suman, B.

    1989-01-01

    Multiparameter data acquisition (MPA) systems which analyse nuclear events with respect to more than one property of the event are essential tools for the study of some complex nuclear phenomena requiring analysis of time coincident spectra. For better throughput and accuracy each parameter is digitized by its own ADC. A stand alone low cost IBM PC based 8-parameter data acquisition system developed by the authors makes use of Address Recording technique for acquiring data from eight 12 bit ADC's in the PC Memory. Two memory buffers in the PC memory are used in ping-pong fashion so that data acquisition in one bank and dumping of data onto PC disk from the other bank can proceed simultaneously. Data is acquired in the PC memory through DMA mode for realising high throughput and hardware interrupt is used for switching banks for data acquisition. A comprehensive software package developed in Turbo-Pascal offers a set of menu-driven interactive commands to the user for setting-up system parameters and control of the system. The system is to be used with pelletron accelerator. (author). 5 figs

  13. PC'eren på arbejde. 3. udgave

    DEFF Research Database (Denmark)

    Andersen, Povl Erik Rostgård

    En generel og ikke-programspecifik introduktion til edb-området med speciel fokus på pc'er og pc-programmel.......En generel og ikke-programspecifik introduktion til edb-området med speciel fokus på pc'er og pc-programmel....

  14. Peak Pc Prediction in Conjunction Analysis: Conjunction Assessment Risk Analysis. Pc Behavior Prediction Models

    Science.gov (United States)

    Vallejo, J.J.; Hejduk, M.D.; Stamey, J. D.

    2015-01-01

    Satellite conjunction risk typically evaluated through the probability of collision (Pc). Considers both conjunction geometry and uncertainties in both state estimates. Conjunction events initially discovered through Joint Space Operations Center (JSpOC) screenings, usually seven days before Time of Closest Approach (TCA). However, JSpOC continues to track objects and issue conjunction updates. Changes in state estimate and reduced propagation time cause Pc to change as event develops. These changes a combination of potentially predictable development and unpredictable changes in state estimate covariance. Operationally useful datum: the peak Pc. If it can reasonably be inferred that the peak Pc value has passed, then risk assessment can be conducted against this peak value. If this value is below remediation level, then event intensity can be relaxed. Can the peak Pc location be reasonably predicted?

  15. Population dose assessment: characteristics of PC CREAM

    International Nuclear Information System (INIS)

    Alonso, Maria T.; Curti, Adriana R.

    2000-01-01

    This paper presents the main features of the PC CREAM, a program for performing radiological impact assessments due to radioactive discharges into the environment during the operation of radioactive and nuclear facilities. PC CREAM is a suite of six programs that can be used to estimate individual and collective radiation doses. The methodology of PC CREAM is based on updated environmental and dosimetric models, including ICRP 60 recommendations. The models include several exposure pathways and the input files are easy to access. The ergonomics of the program improves the user interaction and makes easier the input of local data. This program is useful for performing sensitivity analysis, siting studies and validation of model comparing the activity concentration output data with environmental monitoring data. The methodology of each module is described as well as the output data. (author)

  16. Tablet PC Support of Students' Learning Styles

    Directory of Open Access Journals (Sweden)

    Shreya Kothaneth

    2012-12-01

    Full Text Available In the context of rapid technology development, it comes as no surprise that technology continues to impact the educational domain, challenging traditional teaching and learning styles. This study focuses on how students with different learning styles use instructional technology, and in particular, the tablet PC, to enhance their learning experience. The VARK model was chosen as our theoretical framework as we analyzed responses of an online survey, both from a quantitative and qualitative standpoint. Results indicate that if used correctly, the tablet PC can be used across different learning styles to enrich the educational experience.

  17. PHAST- a spectrum stabilising PC-MCA

    International Nuclear Information System (INIS)

    Mukhopadhyay, P.K.; Satish, P.; Shrivastava, V.D.

    2001-01-01

    Model PHAST, a PC-card with programmable features, incorporates a 100 MHz Wilkinson ADC with conversion gain of 8K. It also provides SCA mode MCS operation. The card caters to the needs of precision nuclear spectroscopy at low to moderate count rates. Spectrum drift may be eliminated by spectrum stabilisation. Proper dead time correction is achieved by Gedcke-Hale or pulse generator based schemes. Multiple cards may be operated together in a single PC in independent operating modes. These cards have onboard histogram memory and updating mechanism. Hence they will usually continue to acquire data in the event of a system crash. (author)

  18. Installation and implementation of PC COSYMA

    International Nuclear Information System (INIS)

    Rossi, J.

    1995-12-01

    COSYMA is a probabilistic reactor accident consequence assessment model developed in the 1980's by the research institutes of the EC countries, primarily by NRPB and KfK. In 1993 a simplified version of the program was released to be implemented on a PC. In the study the PC COSYMA program was applied to calculate as the end points nuclide concentrations, doses received, numbers of health effects, areas affected by countermeasures and other results related to countermeasure strategies. Some results are compared with the results obtained by the ARANO program developed by VTT Energy (Technical Research Centre of Finland) to quarantee proper interpretation of the application. (15 refs.)

  19. Experience using EPICS on PC platforms

    International Nuclear Information System (INIS)

    Hill, J.O.; Kasemire, K.U.

    1997-03-01

    The Experimental Physics and Industrial Control System (EPICS) has been widely adopted in the accelerator community. Although EPICS is available on many platforms, the majority of implementations have used UNIX workstations as clients, and VME- or VXI-based processors for distributed input output controllers. Recently, a significant portion of EPICS has been ported to personal computer (PC) hardware platforms running Microsoft's operating systems, and also Wind River System's real time vxWorks operating system. This development should significantly reduce the cost of deploying EPICS systems, and the prospect of using EPICS together with the many high quality commercial components available for PC platforms is also encouraging. A hybrid system using both PC and traditional platforms is currently being implemented at LANL for LEDA, the low energy demonstration accelerator under construction as part of the Accelerator Production of Tritium (APT) project. To illustrate these developments the authors compare their recent experience deploying a PC-based EPICS system with experience deploying similar systems based on traditional (UNIX-hosted) EPICS hardware and software platforms

  20. An Introduction To PC-TRIM.

    Science.gov (United States)

    John R. Mills

    1989-01-01

    The timber resource inventory model (TRIM) has been adapted to run on person al computers. The personal computer version of TRIM (PC-TRIM) is more widely used than its mainframe parent. Errors that existed in previous versions of TRIM have been corrected. Information is presented to help users with program input and output management in the DOS environment, to...

  1. Investigasi Serangan Malware Njrat Pada PC

    Directory of Open Access Journals (Sweden)

    Devi Rizky Septiani

    2016-12-01

    Full Text Available Malware merupakan salah satu bentuk dari kejahatan komputer yang terjadi pada sebuah sistem jaringan komputer, malware Njrat termasuk jenis Trojan horse. Trojan adalah salah satu jenis malware yang ikut berkembang di dalamnya, yang memungkinkan attacker masuk ke dalam sistem tanpa diketahui oleh pemilik. Penggunaan trojan saat ini lebih ke arah kejahatan dunia maya (cyber crime, salah satu dari malware yang sangat berbahaya karena besarnya dampak kerugian yang ditimbulkan, mulai dari pencurian data penting sampai mengubah hak akses pada PC korban. Sasaran terbanyak penybaran trojan adalah pengguna sistem operasi windows. Penyebaran trojan ini dilakukan dengan metode social engineering, yaitu teknik yang menggunakan kelemahan manusia, sehingga user tanpa curiga langsung mengeksekusi sebuah program yang tidak dikenal.  Aktivitas malware berkaitan erat dengan  performa PC dan juga aktifitas network pada system computer. Penelitian ini bertujuan untuk mengetahui cara kerja malware Njrat dan melakukan investigasi terhadap performa pada system computer. Metodologi yang digunakan dynamic analysis dengan melakukan analisa malware pada suatu sistem dan melihat aktivitas atau proses yang diaktifkan oleh malware tersebut. Dampak perubahan yang terjadi pada PC Target terlihat pada performa masing-masing PC yang telah disisipkan malware. Kata kunci            Malware, Njrat, System computer

  2. An Automation Interface for Kappa PC

    DEFF Research Database (Denmark)

    Hartvig, Susanne C

    1999-01-01

    The reports documents an automation interface for Kappa PC. The automation interface can be used to embed Kappa applications in 32-bit Windowsapplications.The interface includes functions for initialising Kappa, for loading an application, for settingvalues, for getting values, and for stopping...

  3. A PC based thin film dosimeter system

    DEFF Research Database (Denmark)

    Miller, A.; Hargittai, P.; Kovacs, A.

    2000-01-01

    A dosimeter system based on the Riso B3 dosimeter film, an office scanner for use with PC and the associated software is presented. The scanned image is analyzed either with standard software (Paint Shop Pro 5 or Excel) functions or with the computer code "Scanalizer" that allows presentation...

  4. Brugervejledning til pc-programmet STLRAMME

    DEFF Research Database (Denmark)

    Buhelt, M.

    Pc-programmet STLRAMME supplerer SBI-anvisning 187, 'Simple stålrammebygninger. Dimensionering og udførelse'. Programmet kan anvendes til dimensionering af stålrammebygninger med andre mål end dem, der er medtaget i anvisningens tabeller; men det erstatter kun stålramme- og åsetabellerne, ikke an...

  5. PC12 polarity on biopolymer nanogratings

    International Nuclear Information System (INIS)

    Cecchini, M; Ferrari, A; Beltram, F

    2008-01-01

    Cell differentiation properties are strongly entangled with the morphology and physical properties of the extracellular environment. A complete understanding of this interaction needs artificial scaffolds with controlled nano-/micro-topography. We induced specific topographies by nanoimprint lithography (NIL) on tissue culture polystyrene (TCPS) dishes substrates and, using light microscopy and high-magnification scanning-electron-microscopy, quantitatively compared the changes in PC12 differentiation phenotype induced by the periodicity of the nanopatterns. This analysis revealed that nanogratings reduce the number of neurites produced by PC12 cells upon treatment with NGF and that neuronal bipolarity correlated with an increased stretching of the cell body and a reduced length of the cell neuronal protrusions

  6. IBM PC enhances the world's future

    Science.gov (United States)

    Cox, Jozelle

    1988-01-01

    Although the purpose of this research is to illustrate the importance of computers to the public, particularly the IBM PC, present examinations will include computers developed before the IBM PC was brought into use. IBM, as well as other computing facilities, began serving the public years ago, and is continuing to find ways to enhance the existence of man. With new developments in supercomputers like the Cray-2, and the recent advances in artificial intelligence programming, the human race is gaining knowledge at a rapid pace. All have benefited from the development of computers in the world; not only have they brought new assets to life, but have made life more and more of a challenge everyday.

  7. PC imaging system for reactor NDE

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    PC-based systems have been given recent attention by EPRI to organize and manage inspection data (RP-2405-15, TestPro system); integrate with larger, mainframe computers to maintain dialogue for on-site and remote applications; and, in this project, to aid the operator in providing guidance to render decisions on the data. The PC system configuration for this project consisted of a central processing unit (CPU), a hard disk and a floppy disk, 640K bytes of system memory, a high-resolution graphics card and compatible color monitor, and a mouse for operator interaction with software. The software package was written in FORTRAN under the PC Disk Operating System (PC-DOS) and utilized a graphics package for image display. Application of this package to crack-counterbore discrimination in piping welds was investigated. Present automatic techniques utilize signal features from single, A-scan data to render a decision on whether the reflector is benign (i.e., counterbore, weld root) or a crack. However, experienced manual operators in the field make reliable decisions based on the integrated response from the reflector as the transducer is scanned past the suspicious region. Since this software package could display and manipulate ensemble A-scans, spatial features - similar to those used by experts - were developed as discriminants. Ultrasonic responses from intergranular stress corrosion cracks (IGSCCs) were discovered to vary both in time-of-flight and in their amplitude, whereas counterbore responses were more consistent. The software package contains methods for viewing and quantifying these spatial features

  8. PC 386-based version of DORT

    International Nuclear Information System (INIS)

    Tanker, E.

    1992-01-01

    Problems encountered during the adaptation of DORT on a personal computer using a Fortran77 compiler are described, modifications done to solve these are explained. Three test cases were run with the modified version and results are compared with those obtained on an IBM 3090/200. Numerical differences were observed in the last three decimal digits of the computations at most. The running times on the PC were found to be satisfactory for these test cases

  9. Glycosaminoglycan composition of PC12 pheochromocytoma cells: a comparison with PC12D cells, a new subline of PC12 cells

    Energy Technology Data Exchange (ETDEWEB)

    Katoh-Semba, R.; Oohira, A.; Sano, M.; Watanabe, K.; Kitajima, S.; Kashiwamata, S.

    1989-03-01

    PC12D cells, a new subline of conventional PC12 cells, respond not only to nerve growth factor but also to cyclic AMP by extending their neurites. These cells are flat in shape and are similar in appearance to PC12 cells that have been treated with nerve growth factor for a few days. In both cell lines, we have characterized the glycosaminoglycans, the polysaccharide moieties of proteoglycans, which are believed to play an important role in cell adhesion and in cell morphology. Under the present culture conditions, only chondroitin sulfate was detected in the media from PC12 and PC12D cells, whereas both chondroitin sulfate and heparan sulfate were found in the cell layers. The levels of cell-associated heparan sulfate and chondroitin sulfate were about twofold and fourfold higher in PC12D cells than in PC12 cells, respectively. Compared to PC12 cells, the amounts of (/sup 35/S)sulfate incorporated for 48 h into chondroitin sulfate were twofold lower but those into heparan sulfate were 35% higher in PC12D cells. The amount of chondroitin sulfate released by PC12D cells into the medium was about a half of that released by PC12 cells. The ratio of (/sup 35/S)sulfate-labeled heparan sulfate to chondroitin sulfate was 6.2 in PC12D cells and 2.2 in PC12 cells. These results suggest that there may be some correlation between the increase in content of glycosaminoglycans and the change in cell morphology, which is followed by neurite outgrowth.

  10. Pc-based car license plate reading

    Science.gov (United States)

    Tanabe, Katsuyoshi; Marubayashi, Eisaku; Kawashima, Harumi; Nakanishi, Tadashi; Shio, Akio

    1994-03-01

    A PC-based car license plate recognition system has been developed. The system recognizes Chinese characters and Japanese phonetic hiragana characters as well as six digits on Japanese license plates. The system consists of a CCD camera, vehicle sensors, a strobe unit, a monitoring center, and an i486-based PC. The PC includes in its extension slots: a vehicle detector board, a strobe emitter board, and an image grabber board. When a passing vehicle is detected by the vehicle sensors, the strobe emits a pulse of light. The light pulse is synchronized with the time the vehicle image is frozen on an image grabber board. The recognition process is composed of three steps: image thresholding, character region extraction, and matching-based character recognition. The recognition software can handle obscured characters. Experimental results for hundreds of outdoor images showed high recognition performance within relatively short performance times. The results confirmed that the system is applicable to a wide variety of applications such as automatic vehicle identification and travel time measurement.

  11. Phosphatidylcholine (PC) biosynthesis in pancreatic islets of Langerhans

    International Nuclear Information System (INIS)

    Hoffman, J.M.; Laychock, S.G.

    1986-01-01

    Islets of Langerhans isolated from rat pancreata were incubated with [ 14 C]choline to determine the biosynthesis of PC by the CDP choline to determine the biosynthesis of PC by the CDPcholine pathway. Recovery of [ 14 C]PC in islet membranes was time-related, and stimulated by glucose (17mM) during 60 min. The rate of PC synthesis was constant during 60 min with glucose stimulation. In contrast, the sulfonylurea tolbutamide (2 mM) reduced the recovery of [ 14 C]choline in PC, and 8-bromo-cyclic AMP (5 mM) did not significantly affect [ 14 C]PC recovery. Incubation of islets in Ca 2+ -free medium enhanced glucose-stimulated recovery of [ 14 C]choline-labeled PC due to the inhibition of phospholipase and phospholipid hydrolysis. Inhibition of CTP:phosphocholine cytidylyltransferase with 5-deoxy-5'-isobutylthioadenosine (SIBA) reduced [ 14 C]PC levels and insulin release in a concentration dependent manner. Treatment with SIBA also reduced Mg 2+ -dependent Ca 2+ -ATPase activity in islet microsomes. Quantitation of membrane PC showed that glucose stimulation did not alter islet P levels. Thus, islet PC biosynthesis is linked to glucose stimulation and contributes to the maintenance of PC levels in membranes undergoing exocytosis and phospholipid hydrolysis. Adequate PC levels support Ca 2+ pump activity and secretory mechanisms

  12. The USL NASA PC R and D development environment standards

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Moreau, Dennis R.

    1984-01-01

    The development environment standards which have been established in order to control usage of the IBM PC/XT development systems and to prevent interference between projects being currently developed on the PC's are discussed. The standards address the following areas: scheduling PC resources; login/logout procedures; training; file naming conventions; hard disk organization; diskette care; backup procedures; and copying policies.

  13. IBM PC/IX operating system evaluation plan

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Granier, Martin; Hall, Philip P.; Triantafyllopoulos, Spiros

    1984-01-01

    An evaluation plan for the IBM PC/IX Operating System designed for IBM PC/XT computers is discussed. The evaluation plan covers the areas of performance measurement and evaluation, software facilities available, man-machine interface considerations, networking, and the suitability of PC/IX as a development environment within the University of Southwestern Louisiana NASA PC Research and Development project. In order to compare and evaluate the PC/IX system, comparisons with other available UNIX-based systems are also included.

  14. Implementasi Penggunaan Smartphone Android untuk Control PC (Personal Computer

    Directory of Open Access Journals (Sweden)

    Imam Solikin

    2018-05-01

    Full Text Available The purpose of this research is to simplify the control of personal computer (PC such as control pointer, keyboard control and make it easier to do the presentation by controlling the slide remotely using smartphone through wifi connections facility. The smartphone is a multimedia phone that combines PC functionality with microprocessor, memory, and built-in modem to produce smart smartphone gadgets. Problems that occur when performing a presentation such as PC control, control pointer and keyboard control for input should be close to the PC so it is less than optimal in explaining the material. The model used in implementing the use of Android Smartphone for PC control is a conceptual model consisting of several stages: potential and problems, data collection, system testing, test results, and system implementation or implementation. From the results of PC control research can be done by connecting the Smartphone with a PC via wifi network so that PC can be controlled remotely. PC control application is an application that can control PC remotely connected via wifi network connection. Benefits derived from this research make it easy to mengedalikan PC remotely such as facilitate in the percentage and control pointer and control Keyboard for input process.

  15. PC Software for Artificial Intelligence Applications.

    Science.gov (United States)

    Epp, H; Kalin, M; Miller, D

    1988-05-06

    Our review has emphasized that AI tools are programming languages inspired by some problem-solving paradigm. We want to underscore their status as programming languages; even if an AI tool seems to fit a problem perfectly, its proficient use still requires the training and practice associated with any programming language. The programming manuals for PC-Plus, Smalltalk/ V, and Nexpert Object are all tutorial in nature, and the corresponding software packages come with sample applications. We find the manuals to be uniformly good introductions that try to anticipate the problems of a user who is new to the technology. All three vendors offer free technical support by telephone to licensed users. AI tools are sometimes oversold as a way to make programming easy or to avoid it altogether. The truth is that AI tools demand programming-but programming that allows you to concentrate on the essentials of the problem. If we had to implement a diagnostic system, we would look first to a product such as PC-Plus rather than BASIC or C, because PC-Plus is designed specifically for such a problem, whereas these conventional languages are not. If we had to implement a system that required graphical interfaces and could benefit from inheritance, we would look first to an object-oriented system such as Smalltalk/V that provides built-in mechanisms for both. If we had to implement an expert system that called for some mix of AI and conventional techniques, we would look first to a product such as Nexpert Object that integrates various problem-solving technologies. Finally, we might use FORTRAN if we were concerned primarily with programming a well-defined numerical algorithm. AI tools are a valuable complement to traditional languages.

  16. Installation and implementation of PC COSYMA; PC COSYMAn kaeyttoeoenotto ja soveltaminen

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, J [VTT Energy, Espoo (Finland). Nuclear Energy

    1995-12-01

    COSYMA is a probabilistic reactor accident consequence assessment model developed in the 1980`s by the research institutes of the EC countries, primarily by NRPB and KfK. In 1993 a simplified version of the program was released to be implemented on a PC. In the study the PC COSYMA program was applied to calculate as the end points nuclide concentrations, doses received, numbers of health effects, areas affected by countermeasures and other results related to countermeasure strategies. Some results are compared with the results obtained by the ARANO program developed by VTT Energy (Technical Research Centre of Finland) to quarantee proper interpretation of the application. (15 refs.).

  17. Captor of Iodine coupled to PC

    International Nuclear Information System (INIS)

    Arista Romeu, Eduardo; Alonso Abad Dolores; Arteche Diaz, Raul

    2005-01-01

    A measurement - detection system (DETEC -PC) is presented to be used in Iodine Thyroid Uptake Studies. It consists of three elements: the detector with its collimator, a blind measurement module and the application software. The measurement module communicates trough a RS-232 serial interface to the Personal Computer where the application software (DETEC ) resides. The software was designed according to the principles of Object oriented programming using C++ language. It automatically fixes spectrometric measurement parameters and besides patient measurement also performs statistical analysis of a batch of samples. It possesses a PARADOX database with all information of measured patients and an 'on line' help with the system options

  18. PC-assisted translation of photogrammetric papers

    Science.gov (United States)

    Güthner, Karlheinz; Peipe, Jürgen

    A PC-based system for machine translation of photogrammetric papers from the English into the German language and vice versa is described. The computer-assisted translating process is not intended to create a perfect interpretation of a text but to produce a rough rendering of the content of a paper. Starting with the original text, a continuous data flow is effected into the translated version by means of hardware (scanner, personal computer, printer) and software (OCR, translation, word processing, DTP). An essential component of the system is a photogrammetric microdictionary which is being established at present. It is based on several sources, including e.g. the ISPRS Multilingual Dictionary.

  19. PC-based car license plate reader

    Science.gov (United States)

    Hwang, Chung-Mu; Shu, Shyh-Yeong; Chen, Wen-Yu; Chen, Yie-Wern; Wen, Kuang-Pu

    1992-11-01

    A car license plate reader (CLPR) using fuzzy inference and neural network algorithm has been developed in Industrial Technology Research Institute (ITRI) and installed in highway toll stations to identify stolen cars. It takes an average of 0.7 seconds to recognize a car license plate by using a PC with 80486-50 CPU. The recognition rate of the system is about 97%. The techniques of CLPR include vehicle sensing, image grab control, optic pre- processing, lighting, and optic character recognition (OCR). The CLPR can be used in vehicle flow statistics, the checking of stolen vehicles, automatic charging systems in parking lots or garage management, and so on.

  20. Versatile PC-logger for radioisotope measurements

    International Nuclear Information System (INIS)

    Furman, L.; Petryka, L.; Przewlocki, K.; Stegowski, Z.; Wierzbicki, A.

    1998-01-01

    The logger, a personal computer and software is all to set up a radioisotope measuring system. It may find numerous applications in a wide range of disciplines: kinetics description of flow process in industry, slip velocity measurements in hydrotransport, flow rates evaluation in waste water treatment plants, nucleonic gauges in industry, ect. Readings from up to 4 scintillation detectors, the user has set to log, are stored in regular intervals. The user can set the logger to start and stop logging manually, with keyboard or from a program running on a connected PC. Stored data can be transferred to any computer with RS232 serial interface. The logger works equally well together with conventional PC's and 'lap-tops' for field work. Its internal program is stored in nonvolatile RAM. This makes it possible to upgrade or change the code by just down loading a new one. The logger is internal rechargeable batteries for measuring off-line; they remain as a back-up in case the external supply is disconnected or fails. (author)

  1. PC-based Multiple Information System Interface (PC/MISI) detailed design and implementation plan

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Hall, Philip P.

    1985-01-01

    The design plan for the personal computer multiple information system interface (PC/MISI) project is discussed. The document is intended to be used as a blueprint for the implementation of the system. Each component is described in the detail necessary to allow programmers to implement the system. A description of the system data flow and system file structures is given.

  2. PC application in DIII-D neutral beam operation

    International Nuclear Information System (INIS)

    Gladd, A.S.

    1986-01-01

    An IBM PC/AT has been implemented to improve operation of the DIII-D neutral beams. The PC system provides centralization of all beam data with reasonable access for online shot-to-shot control and analysis. The PC hardware was configured to interface all four neutral beam host mini-computers, support multi-tasking, and provide storage for approximately one month's accumulation of beam data. The PC software is composed of commercial packages used for performance and statistical analysis (i.e. LOTUS 123, PC PLOT, etc.) host communications software (i.e. PCLINK, KERMIT, etc.) and applications developed software utilizing FORTRAN and BASIC. The objectives of this paper are to describe the implementation of the PC system, the methods of integrating the various software packages, and the scenario for online control and analysis

  3. Organic photovoltaic effects depending on CuPc layer thickness

    International Nuclear Information System (INIS)

    Hur, Sung Woo; Kim, Tae Wan; Chung, Dong Hoe; Oh, Hyun Seok; Kim, Chung Hyeok; Lee, Joon Ung; Park, Jong Wook

    2004-01-01

    Organic photovoltaic effects were studied in device structures of ITO/CuPc/Al and ITO/CuPc/C 60 /BCP/Al by varying the CuPc layer thickness. Since the exciton diffusion length is relatively short in organic semiconductors, a study on the thickness-dependent photovoltaic effects is important. The thickness of the CuPc layer was varied from 10 nm to 50 nm. We found that the optimum CuPc layer thickness was around 40 nm from the analysis of the current density-voltage characteristics in an ITO/CuPc/Al photovoltaic cell. The efficiency of the device shows that the multi-layered heterojunction structure is more appropriate for photovoltaic cells.

  4. Materials accounting system for an IBM PC

    International Nuclear Information System (INIS)

    Bearse, R.C.; Thomas, R.J.; Henslee, S.P.; Jackson, B.G.; Tracy, D.B.; Pace, D.M.

    1986-01-01

    We have adapted the Los Alamos MASS accounting system for use on an IBM PC/AT at the Fuels Manufacturing Facility (FMF) at Argonne National Laboratory-West (ANL-WEST) in Idaho Falls, Idaho. Cost of hardware and proprietary software was less than $10,000 per station. The system consists of three stations between which accounting information is transferred using floppy disks accompanying special nuclear material shipments. The programs were implemented in dBASEIII and were compiled using the proprietary software CLIPPER. Modifications to the inventory can be posted in just a few minutes, and operator/computer interaction is nearly instantaneous. After the records are built by the user, it takes 4 to 5 seconds to post the results to the database files. A version of this system was specially adapted and is currently in use at the FMF facility at Argonne National Laboratory in Idaho Falls. Initial satisfaction is adequate and software and hardware problems are minimal

  5. Graphics based PC analysis of alpha spectra

    International Nuclear Information System (INIS)

    Chapman, T.C.

    1991-01-01

    New personal computer (PC) software performs interactive analysis of alpha spectra using EGA graphics. Spectra are collected with a commercial MCA board and analyzed using the software described here. The operator is required to approve each peak integration area before analysis proceeds. Sample analysis can use detector efficiencies or spike yields or both. Background corrections are made and upper limit values are calculated when specified. Nuclide identification uses a library of up to 64 nuclides with up to 8 alpha lines for each nuclide. Any one of 32 subset libraries can be used in an analysis. Analysis time is short and is limited by interaction with the operator, not by calculation time. Utilities include nuclide library editing, library subset editing, energy calibration, efficiency calibration, and background update

  6. Design of multichannel counting system for IBM PC and compatibles

    International Nuclear Information System (INIS)

    Majeed, B.; Ahmad, Z.; Osman, A.; Ysain, M.M.

    1995-07-01

    A Multichannel Counting System (MCCS), based on IBM-PC and compatible computer systems have been designed. The MCCS consists of a Multichannel Counting System plug-in interface card (MCCS-PC) for IBM PC and compatibles and a NIM-BIN module (MCCS-NB). The MCCS-PC provides simultaneous monitoring of upto seven independent SCA type inputs. An on board programmable timer provides elapsed time measurement. A menu-driven program for data acquisition and timer control has also been developed. (author) 8 figs

  7. The readout performance evaluation of PowerPC

    International Nuclear Information System (INIS)

    Chu Yuanping; Zhang Hongyu; Zhao Jingwei; Ye Mei; Tao Ning; Zhu Kejun; Tang Suqiu; Guo Yanan

    2003-01-01

    PowerPC, as a powerful low-cost embedded computer, is one of the very important research objects in recent years in the project of BESIII data acquisition system. The researches on the embedded system and embedded computer have achieved many important results in the field of High Energy Physics especially in the data acquisition system. The one of the key points to design an acquisition system using PowerPC is to evaluate the readout ability of PowerPC correctly. The paper introduce some tests for the PowerPC readout performance. (authors)

  8. ELIPGRID-PC: A PC program for calculating hot spot probabilities

    International Nuclear Information System (INIS)

    Davidson, J.R.

    1994-10-01

    ELIPGRID-PC, a new personal computer program has been developed to provide easy access to Singer's 1972 ELIPGRID algorithm for hot-spot detection probabilities. Three features of the program are the ability to determine: (1) the grid size required for specified conditions, (2) the smallest hot spot that can be sampled with a given probability, and (3) the approximate grid size resulting from specified conditions and sampling cost. ELIPGRID-PC also provides probability of hit versus cost data for graphing with spread-sheets or graphics software. The program has been successfully tested using Singer's published ELIPGRID results. An apparent error in the original ELIPGRID code has been uncovered and an appropriate modification incorporated into the new program

  9. A Pc-interface module has been developed that provides an easy way to interface PC

    International Nuclear Information System (INIS)

    Rifai, Ahmad; Gunawan, Usep Setia

    2003-01-01

    A pc-interface module has been developed that provides an easy way to interface PC with I/O devices. This MSC51 micro controller based module accepts series of commands from a personal computer through a serial port. The commands are defined to easily control 24 I/O lines available on the module. These lines can be individually used as either input or output that make the module very verstile. A command is received by the module on ASCII string basis. Each character sent to the module will give an interrupt. The firmware's interrupt handler will store the character in a buffer until end of command character arrives. The firmware then parses and interpreters the command and responses accordingly

  10. A NICE approach to managing large numbers of desktop PC's

    International Nuclear Information System (INIS)

    Foster, David

    1996-01-01

    The problems of managing desktop systems are far from resolved. As we deploy increasing numbers of systems, PC's Mackintoshes and UN*X Workstations. This paper will concentrate on the solution adopted at CERN for the management of the rapidly increasing numbers of desktop PC's in use in all parts of the laboratory. (author)

  11. Application of simplified PC-SAFT to glycol ethers

    DEFF Research Database (Denmark)

    Avlund, Ane Søgaard; Kontogeorgis, Georgios; Michelsen, Michael Locht

    2012-01-01

    The simplified PC-SAFT (sPC-SAFT) equation of state is applied for binary glycol ether-containing mixtures, and it is investigated how the results are influenced by inclusion of intramolecular association in the association theory. Three different glycol ethers are examined: 2-methoxyethanol, 2...

  12. PC Assisted Anatomical Measurements in 3D Using CT Data

    DEFF Research Database (Denmark)

    Hvidtfeldt, Mogens; Pedersen, Steen

    1999-01-01

    To assess facilities and applications of a programme for a PC based CT measurements in 3D of anatomical angelse in the skeleton.......To assess facilities and applications of a programme for a PC based CT measurements in 3D of anatomical angelse in the skeleton....

  13. PrPC from stem cells to cancer

    Directory of Open Access Journals (Sweden)

    Séverine eMartin-Lannerée

    2014-09-01

    Full Text Available The cellular prion protein PrPC was initially discovered as the normal counterpart of the pathological scrapie prion protein PrPSc, the main component of the infectious agent of Transmissible Spongiform Encephalopathies. While clues as to the physiological function of this ubiquitous protein were greatly anticipated from the development of knock-out animals, PrP-null mice turned out to be viable and to develop without major phenotypic abnormalities. Notwithstanding, the discovery that hematopoietic stem cells from PrP-null mice have impaired long-term repopulating potential has set the stage for investigating into the role of PrPC in stem cell biology. A wealth of data have now exemplified that PrPC is expressed in distinct types of stem cells and regulates their self-renewal as well as their differentiation potential. A role for PrPC in the fate restriction of embryonic stem cells has further been proposed. Paralleling these observations, an overexpression of PrPC has been documented in various types of tumours. In line with the contribution of PrPC to stemness and to the proliferation of cancer cells, PrPC was recently found to be enriched in subpopulations of tumour-initiating cells. In the present review, we summarize the current knowledge of the role played by PrPC in stem cell biology and discuss how the subversion of its function may contribute to cancer progression.

  14. Transforming PC Power Supplies into Smart Car Battery Conditioners

    Science.gov (United States)

    Rodriguez-Ascariz, J. M.; Boquete-Vazquez, L.

    2011-01-01

    This paper describes a laboratory project consisting of a PC power supply modification into an intelligent car-battery conditioner with both wireless and wired networking capabilities. Adding a microcontroller to an average PC power supply transforms it into a flexible, intelligent device that can be configured and that is suitable to keep car…

  15. Monte Carlo tests of the ELIPGRID-PC algorithm

    International Nuclear Information System (INIS)

    Davidson, J.R.

    1995-04-01

    The standard tool for calculating the probability of detecting pockets of contamination called hot spots has been the ELIPGRID computer code of Singer and Wickman. The ELIPGRID-PC program has recently made this algorithm available for an IBM reg-sign PC. However, no known independent validation of the ELIPGRID algorithm exists. This document describes a Monte Carlo simulation-based validation of a modified version of the ELIPGRID-PC code. The modified ELIPGRID-PC code is shown to match Monte Carlo-calculated hot-spot detection probabilities to within ±0.5% for 319 out of 320 test cases. The one exception, a very thin elliptical hot spot located within a rectangular sampling grid, differed from the Monte Carlo-calculated probability by about 1%. These results provide confidence in the ability of the modified ELIPGRID-PC code to accurately predict hot-spot detection probabilities within an acceptable range of error

  16. 100 pc renewable energies: the last obstacles

    International Nuclear Information System (INIS)

    Claustre, Raphael; Bringault, Anne; Mery, Jane; Regnier, Yannick; Leca, Christel; Jedliczka, Marc; Houssard, Pascal; Gaboriau, Denis

    2015-01-01

    As some countries or territories have set a target of 100 pc of renewable energies by 2015, a first article discusses the different components of a scenario corresponding to this objective: reduction of primary energy consumption, sobriety, efficiency, electricity and heat production, mobility, development of exchanges and solidarities between territories, new roles for the different actors. A second article briefly presents the situation of different cities and territories in terms of production of renewable energies and of energy savings (Vancouver, Costa Rica, Canaries Islands, the region of Thouars in France, Denmark, Frankfurt, and Bangladesh). Two persons belonging either to a company or to a public body, both committed in energy efficiency issues, give their opinion on issues of governance and innovation. The next article outlines that, despite the content of the law on energy transition, there is still much to be done to develop the empowerment of local communities or, in other words, to introduce an energetic decentralisation. A researcher then outlines the need to introduce a strong tax system in relationship with carbon emission to support the development of renewable energies. An article then describes the example of the Vendee district which has been developing since 2012 an infrastructure of charging points for electric vehicles. The last article outlines the role of training organisations which will have to adapt themselves to new professions in various sectors

  17. Pc-Based Floating Point Imaging Workstation

    Science.gov (United States)

    Guzak, Chris J.; Pier, Richard M.; Chinn, Patty; Kim, Yongmin

    1989-07-01

    The medical, military, scientific and industrial communities have come to rely on imaging and computer graphics for solutions to many types of problems. Systems based on imaging technology are used to acquire and process images, and analyze and extract data from images that would otherwise be of little use. Images can be transformed and enhanced to reveal detail and meaning that would go undetected without imaging techniques. The success of imaging has increased the demand for faster and less expensive imaging systems and as these systems become available, more and more applications are discovered and more demands are made. From the designer's perspective the challenge to meet these demands forces him to attack the problem of imaging from a different perspective. The computing demands of imaging algorithms must be balanced against the desire for affordability and flexibility. Systems must be flexible and easy to use, ready for current applications but at the same time anticipating new, unthought of uses. Here at the University of Washington Image Processing Systems Lab (IPSL) we are focusing our attention on imaging and graphics systems that implement imaging algorithms for use in an interactive environment. We have developed a PC-based imaging workstation with the goal to provide powerful and flexible, floating point processing capabilities, along with graphics functions in an affordable package suitable for diverse environments and many applications.

  18. Application of PC-SAFT to glycol containing systems - PC-SAFT towards a predictive approach

    DEFF Research Database (Denmark)

    Grenner, Andreas; Kontogeorgis, Georgios; von Solms, Nicolas

    2007-01-01

    for estimating pure compound parameters from low molecular weight data and extrapolate to complex compounds. For associating compounds this is not trivial since the two parameters for association (association energy and association volume) need to be fixed for a group. In this work, which focuses on glycols, new...... general pure compound parameters were obtained for PC-SAFT which are able to perform well for both vapor-liquid equilibria (VLE) and liquid-liquid equilibria (LLE). Linear trends of non-association parameters were obtained with respect to the molar mass. However, identical values for the association...

  19. HOTSPOT Health Physics codes for the PC

    Energy Technology Data Exchange (ETDEWEB)

    Homann, S.G.

    1994-03-01

    The HOTSPOT Health Physics codes were created to provide Health Physics personnel with a fast, field-portable calculation tool for evaluating accidents involving radioactive materials. HOTSPOT codes are a first-order approximation of the radiation effects associated with the atmospheric release of radioactive materials. HOTSPOT programs are reasonably accurate for a timely initial assessment. More importantly, HOTSPOT codes produce a consistent output for the same input assumptions and minimize the probability of errors associated with reading a graph incorrectly or scaling a universal nomogram during an emergency. The HOTSPOT codes are designed for short-term (less than 24 hours) release durations. Users requiring radiological release consequences for release scenarios over a longer time period, e.g., annual windrose data, are directed to such long-term models as CAPP88-PC (Parks, 1992). Users requiring more sophisticated modeling capabilities, e.g., complex terrain; multi-location real-time wind field data; etc., are directed to such capabilities as the Department of Energy`s ARAC computer codes (Sullivan, 1993). Four general programs -- Plume, Explosion, Fire, and Resuspension -- calculate a downwind assessment following the release of radioactive material resulting from a continuous or puff release, explosive release, fuel fire, or an area contamination event. Other programs deal with the release of plutonium, uranium, and tritium to expedite an initial assessment of accidents involving nuclear weapons. Additional programs estimate the dose commitment from the inhalation of any one of the radionuclides listed in the database of radionuclides; calibrate a radiation survey instrument for ground-survey measurements; and screen plutonium uptake in the lung (see FIDLER Calibration and LUNG Screening sections).

  20. A TDC-PC based DPAC spectrometer

    International Nuclear Information System (INIS)

    Mayer, A.; Lindgren, B.

    1988-09-01

    In spectroscopies like muon spin rotation or the time differential perturbed angular correlation method the experimentally determined quantity is a time interval between two events. The transformation of this time into a physically handy signal has in most cases been performed by a time-to-amplitude converter (TAC). The resulting voltage has been digitized in a separate analog-to-digital converter (ADC) and entered some type of multichannel analyser (MCA). Apart from not being very convenient the systems have some significant weaknesses: The available size of the total spectrum area is limited due to the MCA. Nonlinearities in TACs and ADCs and noise in the analog part are well known complications. There is no way to see the experimental result, besides the raw data, during the course of the experiment. Here a new type of data collecting system is described. The basic idea, is to substitute the TAC and EDC for a time-to-digital converter (TDC), that is coupled to a personal computer (PC). The computer, used here, is with 256 kbyte of memory, which is sufficient for both the data collection and for the TDC controlling and data treating program DEPACK. The spectrum area is variable, with a predefined standard size of 8 * 2048 channels. On-line data treatment can be performed with the DEPACK program. With the choice of a TDC all problems related to analog parts in the equipment can be circumvented. The TDC can measure both positive and negative times, which enables in a standard 4 detector setup, the simultaneous collection of 8 spectra. If not objected for other reasons, all fast circuit start and stop signals may access the TDC. Since the maximum conversion frequency of the module is 1 MHz an overload protection is not required

  1. HOTSPOT Health Physics codes for the PC

    International Nuclear Information System (INIS)

    Homann, S.G.

    1994-03-01

    The HOTSPOT Health Physics codes were created to provide Health Physics personnel with a fast, field-portable calculation tool for evaluating accidents involving radioactive materials. HOTSPOT codes are a first-order approximation of the radiation effects associated with the atmospheric release of radioactive materials. HOTSPOT programs are reasonably accurate for a timely initial assessment. More importantly, HOTSPOT codes produce a consistent output for the same input assumptions and minimize the probability of errors associated with reading a graph incorrectly or scaling a universal nomogram during an emergency. The HOTSPOT codes are designed for short-term (less than 24 hours) release durations. Users requiring radiological release consequences for release scenarios over a longer time period, e.g., annual windrose data, are directed to such long-term models as CAPP88-PC (Parks, 1992). Users requiring more sophisticated modeling capabilities, e.g., complex terrain; multi-location real-time wind field data; etc., are directed to such capabilities as the Department of Energy's ARAC computer codes (Sullivan, 1993). Four general programs -- Plume, Explosion, Fire, and Resuspension -- calculate a downwind assessment following the release of radioactive material resulting from a continuous or puff release, explosive release, fuel fire, or an area contamination event. Other programs deal with the release of plutonium, uranium, and tritium to expedite an initial assessment of accidents involving nuclear weapons. Additional programs estimate the dose commitment from the inhalation of any one of the radionuclides listed in the database of radionuclides; calibrate a radiation survey instrument for ground-survey measurements; and screen plutonium uptake in the lung (see FIDLER Calibration and LUNG Screening sections)

  2. A photometric map of interstellar reddening within 100 PC

    Science.gov (United States)

    Perry, C. L.; Johnston, L.; Crawford, D. L.

    1982-12-01

    Color excesses and distances are calculated for 300 bright, northern, late F stars using uvby beta photometric indices. The data allow an extension of the earlier maps by Perry and Johnston of the spatial distribution of interstellar reddening into the local (r less than 100 pc) solar neighborhood. Some definite conclusions are made regarding the distribution of interstellar dust in the northern hemisphere and within 300 pc of the sun by merging these results and the polarimetric observations by Tinbergen (1982) for 180 stars within 35 pc of the sun.

  3. PC Farms for Offline Event Reconstruction at Fermilab

    International Nuclear Information System (INIS)

    Beretvas, A.

    1997-03-01

    Fermilab is investigating the use of PC's for HEP computing. As a first step we have built a full offline environment under Linux on a set of Pentium (P5) and Pentium Pro (P6) machines (the ''PC Farm''). The Pythia simulation has been ported to run serially and in parallel (using CPS) on the PC Farm. Fermilab software products and CDF offline packages have also been ported to Linux. Run 1 CDF data has been analyzed on both Linux and SGI (Irix) with essentially identical results. The performance of the system is compared to results with commercial UNIX systems

  4. JEF-PC 2.0. A PC program for viewing evaluated and experimental data

    International Nuclear Information System (INIS)

    Konieczny, M.

    1997-01-01

    In an attempt to make nuclear data more easily accessible to a wider user community, as well as providing a useful tool for experienced users, the NEA has supported the development of PC software for accessing and displaying nuclear data in a user-friendly and intuitive manner. The data contained in JEF-PC version 2.0 is predominantly taken from the Joint Evaluated File (JEF-2.2). The JEF-2.2 library comprises sets of evaluated nuclear data, mainly for fission reactor applications; it contains a number of different types of data, including neutron interaction data, radioactive decay data and fission yield data. The package consists of a central 'driver' program displaying an electronic representation of the Chart of the Nuclides, from which a target nuclide is selected. Through this interface a number of peripheral database modules, containing different categories of basic nuclear data, can be accessed. Cross section data, radioactive decay data, and fission yield data are available in separate modules named CROSS, DECAY and FISSION respectively. (K.A.)

  5. Software Defined Radio Datalink Implementation Using PC-Type Computers

    National Research Council Canada - National Science Library

    Zafeiropoulos, Georgios

    2003-01-01

    The objective of this thesis was to examine the feasibility of implementation and the performance of a Software Defined Radio datalink, using a common PC type host computer and a high level programming language...

  6. PC data station for Hitachi F-2000 spectrofluorimeter

    International Nuclear Information System (INIS)

    Yakub Ali, Mohd; Dhoble, A.R.; Jadhav, R.T.; Godbole, S.V.

    2004-01-01

    The paper describes the PC based data station for stand-alone HIT ACHI F-2000 Spectrofluorimeter, for data acquisition, storage and analysis. The hardware link between the instrument and PC is made through RS232 serial port. The state of art software for control and data management is designed, developed and implemented in Visual Basic (Version 6). The software features on-screen editing of all operation parameters of the instrument and the operational control is achieved by Visual Basic command words communicated through serial port. Using this system, in addition to acquiring and storage of spectral data, it was possible to obtain the normalized absorption spectra of the samples. PC adapted Hitachi F-2000 Spectrofluorimeter can be successfully used for various operations such as photometric detection of UO22+ ions, recording of emission and excitation spectra and time evolution of fluorescence intensity on continuous UV irradiation. The data storage achieved through PC adaptation has also enabled recording of absorption spectra. (author)

  7. 2010 ME70 Workshop (PC1003, EK60)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The third leg of the 2010 SEAMAP Reeffish Survey, PC 1003, was originally scheduled as an experimental multibeam sonar workshop. However, on July 12, 2010, FSV...

  8. Software Reviews. PC Software for Artificial Intelligence Applications.

    Science.gov (United States)

    Epp, Helmut; And Others

    1988-01-01

    Contrasts artificial intelligence and conventional programming languages. Reviews Personal Consultant Plus, Smalltalk/V, and Nexpert Object, which are PC-based products inspired by problem-solving paradigms. Provides information on background and operation of each. (RT)

  9. (PC) tablet penetration among undergraduate students of University ...

    African Journals Online (AJOL)

    Random sampling technique was adopted to select 200 students from ... The findings of the study revealed that PC tablet is a learning tool as students easily view ... computer, information and communication technology, mobile technologies ...

  10. Select PC/windows flat to develop data acquisition system

    International Nuclear Information System (INIS)

    Zhang Jin

    1993-01-01

    Through needing analysis, and also, considering user's ability of payment, the characteristic of China computer market, the computer developing tending, and the system's compatibility and up grade capability, PC/Windows flat are selected to develop a data acquisition system

  11. PC analysis of stochastic differential equations driven by Wiener noise

    KAUST Repository

    Le Maitre, Olivier; Knio, Omar

    2015-01-01

    A polynomial chaos (PC) analysis with stochastic expansion coefficients is proposed for stochastic differential equations driven by additive or multiplicative Wiener noise. It is shown that for this setting, a Galerkin formalism naturally leads

  12. Aspartame-induced apoptosis in PC12 cells

    OpenAIRE

    Horio, Yukari; Sun, Yongkun; Liu, Chuang; Saito, Takeshi; Kurasaki, Masaaki

    2014-01-01

    Aspartame is an artificial sweetner added to many low-calorie foods. The safety of aspartame remains controversial even though there are many studies on its risks. In this study, to understand the physiological effects of trace amounts of artificial sweetners on cells, the effects of aspartame on apoptosis were investigated using a PC12 cell system. In addition, the mechanism of apoptosis induced by aspartame in PC12 cells and effects on apoptotic factors such as cytochrome c, apoptosis-induc...

  13. Multi drop bus controller for IBM PC/AT

    International Nuclear Information System (INIS)

    Bardik, Yu.I.; Kalistratov, E.N.; Matyushin, A.A.; Obukhov, G.A.; Trofimov, N.N.

    1993-01-01

    The module PC-AT-PBC gives a possibility to create a working place based on the computer IBM PC/AT for testing of hardware which is compatible with the multi drop bus. The KP1830BE31 micro program change turns the module into timing generator for power supply controllers of the UNK correction system. The structure of the module, functional parts, library functions and two application programs have been described. 4 refs., 9 figs

  14. PC based 8K multichannel analyser for nuclear spectroscopy

    International Nuclear Information System (INIS)

    Jain, S.K.; Gupta, J.D.; Suman Kumari, B.

    1989-01-01

    An IBM-PC based 8K multichannel analyser(MCA) has been developed which incorporates all the features of an advanced system like very high throughput for data acquisition in PHA as well as MCS modes, fast real-time display, extensive display manipulation facilities, various present controls and concurrent data processing. The compact system hardware consists of a 2 bit wide NIM module and a PC add-on card. Because of external acquisition hardware, the system after initial programming by PC can acquire data independently allowing the PC to be switched off. To attain very high throughput, the most desirable feature of an MCA, a dual-port memory architecture has been used. The asymmetric dual-port RAM, housed in the NIM module offers 24 bit parallel access to the ADC and 8 bit wide access to PC which results in fast real-time histogramic display on the monitor. PC emulation software is menu driven and user friendly. It integrates a comprehensive set of commonly required application routines for concurrent data processing. After the transfer of know-how to the Electronic Corporation of India Ltd. (ECIL), this system is bein g produced at ECIL. (author). 5 refs., 4 figs

  15. CoPc and CoPcF16 on gold: Site-specific charge-transfer processes

    Directory of Open Access Journals (Sweden)

    Fotini Petraki

    2014-04-01

    Full Text Available Interface properties of cobalt(II phthalocyanine (CoPc and cobalt(II hexadecafluoro-phthalocyanine (CoPcF16 to gold are investigated by photo-excited electron spectroscopies (X-ray photoemission spectroscopy (XPS, ultraviolet photoemission spectroscopy (UPS and X-ray excited Auger electron spectroscopy (XAES. It is shown that a bidirectional charge transfer determines the interface energetics for CoPc and CoPcF16 on Au. Combined XPS and XAES measurements allow for the separation of chemical shifts based on different local charges at the considered atom caused by polarization effects. This facilitates a detailed discussion of energetic shifts of core level spectra. The data allow the discussion of site-specific charge-transfer processes.

  16. PC Mobile Warrior with a built-in cellular phone; Keitai denwa naizogata PC 'Mobile warrior

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    A PC Mobile Warrior with a built-in cellular phone has been developed from PC Libretto through cooperation with the NTT DoCoMo. The new personal computer incorporates into itself some distinguished mobile PC features such as Wake On Radio and Wake On Ring which are defined by MCPC (Mobile Computing Promotion Consortium). Wake On Radio is a function that activates the PC upon entry into the zone from outside, and Wake On Ring is another function that does the same upon arrival of a phone call. Installed on these lower order functions are an application program for automatic transmission of stored e-mails making use of the former function and another for automatic reception of FAX messages making use of the latter function. (translated by NEDO)

  17. Guest Foreword by Lord Phillips KG PC

    Directory of Open Access Journals (Sweden)

    Nicholas A. Phillips

    2012-04-01

    Full Text Available The Rt Hon The Lord Phillips of Worth Matravers KG PC, President of the Supreme Court of the United Kingdom of Great Britain and Northern Ireland Ambition and excellence. Those two words epitomize Qatar. Under the leadership of his Highness the Emir, this small State has set out to make an impact on the world that belies its size. Ambitious was the plan to have an international broadcasting station. Ambitious was the plan to build from scratch a Museum of Islamic Art. Ambitious was the bid – the successful bid to host the World Cup in 2022. Ambitious is the bid to stage the Olympic Games in 2020. Qatar not merely has ambitions, it realizes its ambitions. And when it does so it is not enough to say that the result is ‘world class’, for Qatar sets out to be a world leader in whatever it puts its hand to. Excellence is the norm. Al Jazeera has established itself as the broadcasting station of choice for many throughout the world. The Doha Museum of Islamic Art is recognized as being second to none. In addition, the scale and standard of development in Doha itself is setting new standards of excellence in the fields of architecture and civil engineering. Thus when Qatar focuses its energies on education and the law, high achievements are expected. I shall have the honour of helping to achieve those expectations when I succeed Lord Woolf as President of Qatar’s new and impressive Civil and Commercial Court. The College of Law at Qatar University is already achieving excellence in the field of legal education. So, naturally, all expect great things of this new International Review of Law and I am delighted to have been invited to welcome it by this foreword. The range of the first edition is both international and topical. Those countries that have experienced the turbulence of the Arab Spring are settling new constitutions, and other countries are bent on constitutional reform designed to avoid such turbulence. So an erudite article on

  18. Salinomycin Exerts Anticancer Effects on PC-3 Cells and PC-3-Derived Cancer Stem Cells In Vitro and In Vivo

    Directory of Open Access Journals (Sweden)

    Yunsheng Zhang

    2017-01-01

    Full Text Available Salinomycin is an antibiotic isolated from Streptomyces albus that selectively kills cancer stem cells (CSCs. However, the antitumor mechanism of salinomycin is unclear. This study investigated the chemotherapeutic efficacy of salinomycin in human prostate cancer PC-3 cells. We found that cytotoxicity of salinomycin to PC-3 cells was stronger than to nonmalignant prostate cell RWPE-1, and exposure to salinomycin induced G2/M phage arrest and apoptosis of PC-3 cells. A mechanistic study found salinomycin suppressed Wnt/β-catenin pathway to induce apoptosis of PC-3 cells. An in vivo experiment confirmed that salinomycin suppressed tumorigenesis in a NOD/SCID mice xenograft model generated from implanted PC-3 cells by inhibiting the Wnt/β-catenin pathway, since the total β-catenin protein level was reduced and the downstream target c-Myc level was significantly downregulated. We also showed that salinomycin, but not paclitaxel, triggered more apoptosis in aldehyde dehydrogenase- (ALDH- positive PC-3 cells, which were considered as the prostate cancer stem cells, suggesting that salinomycin may be a promising chemotherapeutic to target CSCs. In conclusion, this study suggests that salinomycin reduces resistance and relapse of prostate tumor by killing cancer cells as well as CSCs.

  19. PC Tutor. Bericht uber ein PC-gestutzes Tutorensystem = PC Tutor. Report on a Tutoring System with Personal Computer. ZIFF Papiere 75.

    Science.gov (United States)

    Fritsch, Helmut

    A project was conducted to increase as well as to professionalize communication between tutors and learners in a West German university's distance education program by the use of personal computers. Two tutors worked on the systematic development of a PC-based correcting system. The goal, apart from developing general language skills in English,…

  20. Empirically modelled Pc3 activity based on solar wind parameters

    Directory of Open Access Journals (Sweden)

    B. Heilig

    2010-09-01

    Full Text Available It is known that under certain solar wind (SW/interplanetary magnetic field (IMF conditions (e.g. high SW speed, low cone angle the occurrence of ground-level Pc3–4 pulsations is more likely. In this paper we demonstrate that in the event of anomalously low SW particle density, Pc3 activity is extremely low regardless of otherwise favourable SW speed and cone angle. We re-investigate the SW control of Pc3 pulsation activity through a statistical analysis and two empirical models with emphasis on the influence of SW density on Pc3 activity. We utilise SW and IMF measurements from the OMNI project and ground-based magnetometer measurements from the MM100 array to relate SW and IMF measurements to the occurrence of Pc3 activity. Multiple linear regression and artificial neural network models are used in iterative processes in order to identify sets of SW-based input parameters, which optimally reproduce a set of Pc3 activity data. The inclusion of SW density in the parameter set significantly improves the models. Not only the density itself, but other density related parameters, such as the dynamic pressure of the SW, or the standoff distance of the magnetopause work equally well in the model. The disappearance of Pc3s during low-density events can have at least four reasons according to the existing upstream wave theory: 1. Pausing the ion-cyclotron resonance that generates the upstream ultra low frequency waves in the absence of protons, 2. Weakening of the bow shock that implies less efficient reflection, 3. The SW becomes sub-Alfvénic and hence it is not able to sweep back the waves propagating upstream with the Alfvén-speed, and 4. The increase of the standoff distance of the magnetopause (and of the bow shock. Although the models cannot account for the lack of Pc3s during intervals when the SW density is extremely low, the resulting sets of optimal model inputs support the generation of mid latitude Pc3 activity predominantly through

  1. Test of radiation hardness of pcCVD detectors

    Energy Technology Data Exchange (ETDEWEB)

    Schlemme, Steffen [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Technische Universitaet Darmstadt (Germany); Enders, Joachim [Technische Universitaet Darmstadt (Germany); Figuera, P.; Salamone, S. [LNS-INFN Catania (Italy); Fruehauf, J.; Kis, Mladen; Kratz, A.; Kurz, N.; Loechner, S.; Nociforo, Chiara; Schirru, Fabio; Szczepanczyk, B.; Traeger, M.; Visinka, R. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Musumarra, A. [LNS-INFN Catania (Italy); University of Catania (Italy)

    2016-07-01

    The new in-flight separator Super-FRS is under construction at the Facility for Antiproton and Ion Research (FAIR, Darmstadt). Ion rates up to 3 x 10{sup 11} {sup 238}U/spill demand an adaption of detectors to a high radiation environment. A test experiment to investigate the radiation hardness of polycrystalline diamond detectors (pcCVD) was performed at the LNS-INFN in Catania using a {sup 12}C beam at 62 MeV/u and intensities of up to 1.5 pnA. The setup consisted of pcCVD strip detectors to measure the beam profile, a single crystal diamond detector to calibrate the ionisation chamber working in current mode as a beam intensity monitor and a pcCVD sample to be irradiated. The IC used was designed for FAIR and showed a stable counting rate allowing us to calibrate and perform beam intensity measurements with it. The total measured counts on the sample were 8.25 x 10{sup 11} counts/mm{sup 2} over a period of 60 hours. Digital waveforms of the pcCVD signals were taken with an oscilloscope and analysed. The results showed no change of the pcCVD signal properties during the entire irradiation.

  2. PcToll2 positively regulates the expression of antimicrobial peptides by promoting PcATF4 translocation into the nucleus.

    Science.gov (United States)

    Lan, Jiang-Feng; Zhao, Li-Juan; Wei, Shun; Wang, Yuan; Lin, Li; Li, Xin-Cang

    2016-11-01

    Drosophila Toll and mammalian Toll-like receptors (TLRs) are a family of evolutionarily conserved immune receptors that play a crucial role in the first-line defense against intruded pathogens. Activating transcription factor 4 (ATF4), a member of the ATF/CREB transcription factor family, is an important factor that participates in TLR signaling and other physiological processes. However, in crustaceans, whether ATF4 homologs were involved in TLR signaling remains unclear. In the current study, we identified a Toll homolog PcToll2 and a novel ATF4 homolog PcATF4 from Procambarus clarkii, and analyzed the likely regulatory activity of PcATF4 in PcToll2 signaling. The complete cDNA sequence of PcToll2 was 4175 bp long containing an open reading frame of 2820 bp encoding a 939-amino acid protein, and the cDNA sequence of PcATF4 was 2027 bp long with an open reading frame of 1296 bp encoding a 431-amino acid protein. PcToll2 and human TLR4 shared the high identity and they were grouped into a cluster. Furthermore, PcToll2 had a close relationship with other shrimp TLRs that possessed potential antibacterial activity. PcToll2 was highly expressed in the hemocytes, heart and gills, while PcATF4 mainly distributed in gills. Upon challenge with Vibrio parahemolyticus, PcToll2 and PcATF4 together with the antimicrobial peptides of ALF1 and ALF2 were significantly up-regulated in the hemocytes, and the PcATF4 was translocated into the nucleus. After PcToll2 silencing and challenge with Vibrio, the translocation of PcATF4 into the nucleus was inhibited and the expression of ALF1 and ALF2 was reduced, but the expression of PcDorsal and PcSTAT was not affected. Furthermore, after PcATF4 knockdown and challenge with or without Vibrio, the expression of ALF1 and ALF2 was also decreased while the expression of PcToll2 was upregulated. These results suggested that PcToll2 might regulate the expression of ALF1 and ALF2 by promoting the import of PcATF4, instead of the routine

  3. Demonstration of a PC 25 Fuel Cell in Russia

    Energy Technology Data Exchange (ETDEWEB)

    John C. Trocciola; Thomas N. Pompa; Linda S. Boyd

    2004-09-01

    This project involved the installation of a 200kW PC25C{trademark} phosphoric-acid fuel cell power plant at Orgenergogaz, a Gazprom industrial site in Russia. In April 1997, a PC25C{trademark} was sold by ONSI Corporation to Orgenergogaz, a subsidiary of the Russian company ''Gazprom''. Due to instabilities in the Russian financial markets, at that time, the unit was never installed and started by Orgenergogaz. In October of 2001 International Fuel Cells (IFC), now known as UTC Fuel Cells (UTCFC), received a financial assistance award from the United States Department of Energy (DOE) entitled ''Demonstration of PC 25 Fuel Cell in Russia''. Three major tasks were part of this award: the inspection of the proposed site and system, start-up assistance, and installation and operation of the powerplant.

  4. Transfer and development of the PC version of ABAQUS program

    International Nuclear Information System (INIS)

    Li Xiaofeng; Zhu Yuqiao

    1998-01-01

    The transfer and development of the PC version of ABAQUS,a large nonlinear mechanical finite element analysis program, are carried out. Some special problem such as difference of the floating data format in different computers and the computer's unusual dead halt during the data transfer is solved and the visualized I/O capability is added in the redevelopment. Thus, by utilizing the visual capability, the intensity of analysis works is reduced, and the correctness of analysis is ensured. The PC ABAQUS are tested by the standard examples from VAX version of ABAQUS and the calculation results are correct. The results of calculation of stress and deformation for CEFR shell structure with PC ABAQUS and ADINA codes agree very well

  5. Aspartame-induced apoptosis in PC12 cells.

    Science.gov (United States)

    Horio, Yukari; Sun, Yongkun; Liu, Chuang; Saito, Takeshi; Kurasaki, Masaaki

    2014-01-01

    Aspartame is an artificial sweetner added to many low-calorie foods. The safety of aspartame remains controversial even though there are many studies on its risks. In this study, to understand the physiological effects of trace amounts of artificial sweetners on cells, the effects of aspartame on apoptosis were investigated using a PC12 cell system. In addition, the mechanism of apoptosis induced by aspartame in PC12 cells and effects on apoptotic factors such as cytochrome c, apoptosis-inducing factor, and caspase family proteins were studied by Western blotting and RT-PCR. Aspartame-induced apoptosis in PC12 cells in a dose-dependent manner. In addition, aspartame exposure increased the expressions of caspases 8 and 9, and cytochrome c. These results indicate that aspartame induces apoptosis mainly via mitochondrial pathway involved in apoptosis due to oxigen toxicity. Copyright © 2013 Elsevier B.V. All rights reserved.

  6. Wind tunnel test on PC cable-stayed bridge; PC shachokyo no taifu seino shiken

    Energy Technology Data Exchange (ETDEWEB)

    Kubo, Y. [Kyushu Inst. of Technology, Kitakyushu (Japan). Faculty of Engineering

    1997-05-30

    This paper describes the wind tunnel test on a PC cable-stayed bridge. The aerodynamic force that acts on a building is represented by the drag that works in the wind direction, the lift that works perpendicularly to the wind direction, and the aerodynamic moment that causes rotation. In the measurement of wind load, a girder is partially extracted in the wind tunnel and set in a three-component balance, and the drag, lift, and aerodynamic moment are measured using a strain meter while blowing the wind. In a wind tunnel experiment, the similarity on Reynolds number, field number, rigidity, hydraulic force, structural attenuation, and reduced wind velocity is required. However, the wind velocity in the actual bridge uses the same air as that in an experiment. The similarity rule on the Reynolds is not thus satisfied. It is necessary to cause no self-excited vibration (galloping and flutter) as wind-resistant performance and suppress the eddy excitation to less than the allowable amplitude. Moreover, the three-dimensional experiment using an elastic model is conducted in addition to the two-dimensional experiment using a rigid model. In the three-dimensional experiment, various vibration modes that occur in the actual bridge appear. 12 refs., 15 figs.

  7. Design of Usui bridge (PC cable stayed bridge). Usuihashi (PC shachokyo) no sekkei ni tsuite

    Energy Technology Data Exchange (ETDEWEB)

    Kido, M.; Iizuka, Y. (Japan Highway Public Corp., Tokyo (Japan)); Tanaka, S.; Otsuka, K. (P.S. Concrete Co. Ltd. Kajima Corp. Joint Venture, Tokyo (Japan)); Kitakuni, S. (Kajima Corp., Tokyo (Japan))

    1991-11-30

    Structure and design of single suspension PC cable bridge, which is first kind of high way bridge in Japan and aiming to start for general use by March, 1993, are reported. As a construction outline, main construction quantity and general layout of the whole bridge together with the selective detail and characteristics of the diagonal member, tower, main girder and tower support member, are cited. Design conditions( load, materials, allowable stress and others ), basic plan of the design, and structure analysis( surface stress framed structure analysis, stereoscopic framework analysis and FEM analysis of local stress ) are explained. Design of structure member like main girder is based on diagonal member tension, wave shearing force, level of diagonal strain stress, bending stress when diagonal member anchors the deformed main tower caused by living load during earth quake, principal stress of main tower junction and local stress etc. Main tower support member design is based on the results of corbel shearing force at varied cross section and main stress, and diagonal member design is decided by allowable stress. Diagonal member anchorage traverse beam design depends on bending moment of traverse beam and shearing force. 3 refs., 15 figs., 1 tab.

  8. PC-based digital feedback control for scanning force microscope

    International Nuclear Information System (INIS)

    Mohd Ashhar Khalid

    2002-01-01

    In the past, most digital feedback implementation for scanned-probe microscope were based on a digital signal processor (DSP). At present DSP plug-in card with the input-output interface module is still expensive compared to a fast pentium PC motherboard. For a magnetic force microscope (MFM) digital feedback has an advantage where the magnetic signal can be easily separated from the topographic signal. In this paper, a simple low-cost PC-based digital feedback and imaging system for Scanning Force Microscope (SFM) is presented. (Author)

  9. CC-3 CAMAC crate controller for IBM PC

    International Nuclear Information System (INIS)

    Khare, A.N.; Ghodgaonkar, M.D.; Bairi, B.R.

    1991-01-01

    The specifications and implementation details of CAMAC Crate Controller CC-3 for IBM-PC compatible as a host computer, having capability to transfer high speed data with direct memory access (DMA) scheme and logic to execute CAMAC cycles directly from the crate controller, to implement the block algorithms specified in ANSI/IEEE Std. 683-1976 (Reaff-1981) are described. The maximum data transfer rate measured with 8 bit interface of PC-AT is 240K byte per second. This work is carried out under Seventh Five Year Plan Project on Modernisation of reactor Control Instrumentation and Development of CAMAC and Fastbus Instrumentation. (author). 9 refs., 5 figs., 4 appendixes

  10. Data Communication PC/NaI-borehole probe (Hardware & Software)

    DEFF Research Database (Denmark)

    Madsen, Peter Buch

    Development of new hard- & software to a NaI borehole probe on a PC. Save data from the probe each 10'th sec, handle the data from the probe and make calculations every 10'th sec and show the results on the monitor.......Development of new hard- & software to a NaI borehole probe on a PC. Save data from the probe each 10'th sec, handle the data from the probe and make calculations every 10'th sec and show the results on the monitor....

  11. Performance Evaluation of a Multipurpose Bare PC Gateway

    DEFF Research Database (Denmark)

    Tsetse, Anthony; Appiah-Kubi, Patrick; Loukili, Alae

    2015-01-01

    . Different solutions (6to4 tunneling, IVI translation, NAT64, DNS64 etc.), have being proposed but these are all standalone systems. In this paper we discuss the design,implementation and performance evaluation of a multipurpose Bare PC Gateway which incorporates Network Address translation (NAT), 6to4...... results indicate a relatively better performance (18%-45%) of the Bare PC gateway compared to a Linux gateway (running the functionalities as standalone systems). We believe the proposed solution could easily scale to wide area networks and also provide a cost efficient solution...

  12. PC add on card for processing of LSC signals

    International Nuclear Information System (INIS)

    Jadhav, S.R.; Nikhare, D.M.; Gurna, R.K.; Paulson, Molly; Kulkarni, C.P.; Vaidya, P.P.

    2001-01-01

    This paper describes PC- add on card developed at Electronics Division for processing of LSC signals. This card uses highly integrated digital and analog circuits, for entire processing of signals available from preamplifiers to get complete beta energy spectrum corresponding to coincident events in Liquid Scintillation Counting. LSC card along with High Voltage PC-add on card gives complete electronics required for LSC system. This card is also used in automatic LSC system along with interface circuits, which are used to control mechanical movements. (author)

  13. Quality assessment of platelet concentrates prepared by platelet rich plasma-platelet concentrate, buffy coat poor-platelet concentrate (BC-PC and apheresis-PC methods

    Directory of Open Access Journals (Sweden)

    Singh Ravindra

    2009-01-01

    Full Text Available Background: Platelet rich plasma-platelet concentrate (PRP-PC, buffy coat poor-platelet concentrate (BC-PC, and apheresis-PC were prepared and their quality parameters were assessed. Study Design: In this study, the following platelet products were prepared: from random donor platelets (i platelet rich plasma - platelet concentrate (PRP-PC, and (ii buffy coat poor- platelet concentrate (BC-PC and (iii single donor platelets (apheresis-PC by different methods. Their quality was assessed using the following parameters: swirling, volume of the platelet concentrate, platelet count, WBC count and pH. Results: A total of 146 platelet concentrates (64 of PRP-PC, 62 of BC-PC and 20 of apheresis-PC were enrolled in this study. The mean volume of PRP-PC, BC-PC and apheresis-PC was 62.30±22.68 ml, 68.81±22.95 ml and 214.05±9.91 ml and ranged from 22-135 ml, 32-133 ml and 200-251 ml respectively. The mean platelet count of PRP-PC, BC-PC and apheresis-PC was 7.6±2.97 x 1010/unit, 7.3±2.98 x 1010/unit and 4.13±1.32 x 1011/unit and ranged from 3.2-16.2 x 1010/unit, 0.6-16.4 x 1010/unit and 1.22-8.9 x 1011/unit respectively. The mean WBC count in PRP-PC (n = 10, BC-PC (n = 10 and apheresis-PC (n = 6 units was 4.05±0.48 x 107/unit, 2.08±0.39 x 107/unit and 4.8±0.8 x 106/unit and ranged from 3.4 -4.77 x 107/unit, 1.6-2.7 x 107/unit and 3.2 - 5.2 x 106/unit respectively. A total of 26 units were analyzed for pH changes. Out of these units, 10 each were PRP-PC and BC-PC and 6 units were apheresis-PC. Their mean pH was 6.7±0.26 (mean±SD and ranged from 6.5 - 7.0 and no difference was observed among all three types of platelet concentrate. Conclusion: PRP-PC and BC-PC units were comparable in terms of swirling, platelet count per unit and pH. As expected, we found WBC contamination to be less in BC-PC than PRP-PC units. Variation in volume was more in BC-PC than PRP-PC units and this suggests that further standardization is required for preparation of BC-PC

  14. An Apple for Your IBM PC--The Quadlink Board.

    Science.gov (United States)

    Owen, G. Scott

    1984-01-01

    Describes nature and installation of the QUADLINK board which allows Apple software to be run on IBM PC microcomputers. Although programs tested ran without problems, users should test their own programs since there are some copy protection schemes that can baffle the board. (JN)

  15. Mathematics Programming on the Apple II and IBM PC.

    Science.gov (United States)

    Myers, Roy E.; Schneider, David I.

    1987-01-01

    Details the features of BASIC used in mathematics programming and provides the information needed to translate between the Apple II and IBM PC computers. Discusses inputing a user-defined function, setting scroll windows, displaying subscripts and exponents, variable names, mathematical characters and special symbols. (TW)

  16. Characteristics of CoPc/CdS hybrid diode device

    Indian Academy of Sciences (India)

    Administrator

    CdS/CoPc hybrid heterojunctions were fabricated and characterized. CdS films were deposited by the spray pyrolysis technique on indium tin oxide (ITO)-coated glass substrates and ... ing solution was prepared by dissolving 0.025 M CdCl2.

  17. A linear algebra course with PC-MATLAB : some experiences

    NARCIS (Netherlands)

    Smits, J.G.M.M.; Rijpkema, J.J.M.

    1992-01-01

    The authors present their views on the impact that the use of computers and software packages should have on the contents of a first service course on linear algebra. Furthermore they report on their experiences using the software package PC-MATLAB in such a course.

  18. Desktop Publishing in a PC-Based Environment.

    Science.gov (United States)

    Sims, Harold A.

    1987-01-01

    Identifies, considers, and interrelates the functionality of hardware, firmware, and software types; discusses the relationship of input and output devices in the PC-based desktop publishing environment; and reports some of what has been experienced in three years of working intensively in/with desktop publishing devices and solutions. (MES)

  19. Teaching Mathematics in the PC Lab--The Students' Viewpoints

    Science.gov (United States)

    Schmidt, Karsten; Kohler, Anke

    2013-01-01

    The Matrix Algebra portion of the intermediate mathematics course at the Schmalkalden University Faculty of Business and Economics has been moved from a traditional classroom setting to a technology-based setting in the PC lab. A Computer Algebra System license was acquired that also allows its use on the students' own PCs. A survey was carried…

  20. PC-ECONPACK Version 3.0 Users Manual.

    Science.gov (United States)

    1991-11-01

    for inclusi on in cost sensitivity analysis UPDer Limit of the Change (%). PC-ECONPACK varies all the stipulated expense items both in an upward...Assumptions as stated in the Assumptions text information block. This section is used to discuss why certain alternatives were selected for inclusi ,n in the

  1. Qualification plan for the Genmod-PC computer program

    International Nuclear Information System (INIS)

    Richardson, R.B.; Wright, G.M.; Dunford, D.W.; Linauskas, S.H.

    2002-07-01

    Genmod-PC is an internal dosimetry code that uses Microsoft Windows operating system, and that currently calculates radionuclide doses and intakes for an adult male. This report provides a plan for specifying the quality assurance measures that conform to the recommendations of the Canadian Standards Association, as well as AECL procedural requirements for a legacy computer program developed at AECL. (author)

  2. PC version of PRIS (Power Reactor Information System)

    International Nuclear Information System (INIS)

    Fukala, J.; Stanik, Z.; White, D.

    1990-05-01

    The IAEA has been collecting operating experience data on nuclear power plants in the Member States since 1970. In 1980 a computerized database was established, the IAEA Power Reactor Information System (PRIS). To make PRIS data available to the Member States in a more convenient format, the development of a PC version of PRIS started in 1989

  3. IBM PC based automatic drive system for Bulat setup

    International Nuclear Information System (INIS)

    Luchaninov, A.A.; Tolok, V.T.

    1999-01-01

    Non-expensive computer drive system for Bulat setup is described. System's hardware consists of IBM PC and conjunction block, providing 12 output channels, Software includes the main program, utilities and technology processes database. System may be used at surface modification processes, especially multilayer multicomponent coatings deposition

  4. Group Contribution sPC-SAFT Equation of State

    DEFF Research Database (Denmark)

    Tihic, Amra

    2008-01-01

    Modellering af termodynamiske egenskaber og faseligevægte er en udfordring for den kemiske industri. Forenklet Perturbed Chains-Statistical Associating Fluid Theory (sPC-SAFT) er en tilstandsligning med udbredt anvendelse i en række industrielle sammenhænge. Modellen anvender tre parametre: segment...

  5. IBM-PC-based reactor neutronics analysis package

    International Nuclear Information System (INIS)

    Nigg, D.W.; Wessol, D.E.; Grimesey, R.A.; Parsons, D.K.; Wheeler, F.J.; Yoon, W.Y.; Lake, J.A.

    1985-01-01

    Technical advances over the past few years have led to a situation where a wide range of complex scientific computations can now be done on properly configured microcomputers such as the IBM-PC (personal computer). For a number of reasons, including security, economy, and user convenience, the development of a comprehensive system of reactor neutronics codes suitable for operation on the IBM-PC has been undertaken at the Idaho National Engineering Laboratory (INEL). It is anticipated that a PC-based code system could also have wide applicability in the nuclear engineering education community since conversion of software generated by national laboratories and others to college and university mainframe hardware has historically been a time-consuming process that has sometimes met with only limited success. This paper discusses the philosophy behind the INEL reactor neutronics PC code system and describes those parts of the system that are currently complete, those that are now under development, and those that are still in the planning stage

  6. Design and Development of a PC- Based temperature monitoring ...

    African Journals Online (AJOL)

    The design of the work involves a circuit that measures the surrounding temperature using appropriate sensors and the sensor output is then converted to digital signals after due processing and conditioning of the signals. There is also an interface circuit configured to make it compatible with the PC hardware. This design ...

  7. Privacy Impact Assessment for the PC Label System

    Science.gov (United States)

    The PC Label System collects contact information for individuals with an interest in EPA's Region 1. Learn how this data will be collected in the system, how it will be used, access to the data, the purpose of data collection, and record retention policies

  8. Electronic States of IC60BA and PC71BM

    International Nuclear Information System (INIS)

    Sheng Chun-Qi; Wang Peng; Shen Ying; Li Wen-Jie; Li Hong-Nian; Zhang Wen-Hua; Zhu Jun-Fa; Lai Guo-Qiao

    2013-01-01

    We investigate the electronic states of IC 60 BA and PC 71 BM using first-principles calculations and photoelectron spectroscopy (PES) measurements. The energy level structures for all possible isomers are reported and compared with those of C 60 , C 70 and PC 61 BM. The attachment of the side chains can raise the LUMO energies and decrease the HOMO-LUMO gaps, and thus helps to increase the power-conversion efficiency of bulk heterojunction solar cells. In the PES studies, we prepared IC 60 BA and PC 71 BM films on Si:H(111) substrates to construct adsorbate/substrate interfaces describable with the integer charge-transfer (ICT) model. Successful measurements then revealed that one of the most important material properties for an electron acceptor, the energy of the negative integer charge-transfer state (E ICT− ), is 4.31 eV below the vacuum level for PC 71 BM. The E ICT− of IC 60 BA is smaller than 4.14 eV

  9. Prostate carcinoma (PC) - an organ-related specific pathological neoplasm

    International Nuclear Information System (INIS)

    Massmann, J.; Funk, A.; Altwein, J.; Praetorius, M.

    2003-01-01

    The organ- and tumour-related specific characteristics of prostate carcinoma (PC) are presented in an overview under various aspects. It is the key for understanding pathological changes, including PC, to consider the subdivision of the prostate into anatomically and functionally distinguishable zones, especially the transitional zone (TZ) and the peripheral zone (PZ). The pseudoneoplastic hyperplasia of the TZ, combined with inflammatory consequences and age-related changes, forms a differential diagnostic challenge to both clinico-radiological diagnosis and macroscopic and microscopic examination. High-degree prostatic intra-epithelial neoplasia (PIN III) and atypical adenomatous hyperplasia (AAH) are presented as precursor lesions of PC with varying significance and assessment. Moreover, there are discussed the following characteristic features of PC: localisation types, focality, volume, progression, double-graduation according to Gleason, tumour stage, and prognosis. The most important prognosis factors of PC (category I) include the categories of the TNM system, such as stage, surgical marginal situation, degree and also the preoperative PSA level as a (poor) substitute for the tumour volume. Potential prognosis parameters (category II) show the tumour volume and the DNS ploidy, while there continues to exist a large number of non-established parameters (category III). The prognostic validity of the pathological examinations depends, on the one hand, on the tissue extent (needle biopsy, transurethral resection (TURP), so-called simple prostatectomy, radical prostatectomy (RPE)) and the prostate zones covered. On the other hand, the prognostic certainty also depends on the tumour-adequate macroscopic and microscopic assessment of an RPE that can only be a partial or complete handling in transversal large-area sections. (orig.) [de

  10. Induction of cytoprotective autophagy in PC-12 cells by cadmium

    International Nuclear Information System (INIS)

    Wang, Qiwen; Zhu, Jiaqiao; Zhang, Kangbao; Jiang, Chenyang; Wang, Yi; Yuan, Yan; Bian, Jianchun; Liu, Xuezhong; Gu, Jianhong; Liu, Zongping

    2013-01-01

    Highlights: •Cadmium can promote early upregulation of autophagy in PC-12 cells. •Autophagy precedes apoptosis in cadmium-treated PC-12 cells. •Cadmium-induced autophagy is cytoprotective in PC-12 cells. •Class III PI3K/beclin-1/Bcl-2 signaling pathway plays a positive role in cadmium-triggered autophagy. -- Abstract: Laboratory data have demonstrated that cadmium (Cd) may induce neuronal apoptosis. However, little is known about the role of autophagy in neurons. In this study, cell viability decreased in a dose- and time-dependent manner after treatment with Cd in PC-12 cells. As cells were exposed to Cd, the levels of LC3-II proteins became elevated, specific punctate distribution of endogenous LC3-II increased, and numerous autophagosomes appeared, which suggest that Cd induced a high level of autophagy. In the late stages of autophagy, an increase in the apoptosis ratio was observed. Likewise, pre-treatment with chloroquine (an autophagic inhibitor) and rapamycin (an autophagic inducer) resulted in an increased and decreased percentage of apoptosis in contrast to other Cd-treated groups, respectively. The results indicate that autophagy delayed apoptosis in Cd-treated PC-12 cells. Furthermore, co-treatment of cells with chloroquine reduced autophagy and cell activity. However, rapamycin had an opposite effect on autophagy and cell activity. Moreover, class III PI3 K/beclin-1/Bcl-2 signaling pathways served a function in Cd-induced autophagy. The findings suggest that Cd can induce cytoprotective autophagy by activating class III PI3 K/beclin-1/Bcl-2 signaling pathways. In sum, this study strongly suggests that autophagy may serve a positive function in the reduction of Cd-induced cytotoxicity

  11. Efficient Server-Aided 2PC for Mobile Phones

    Directory of Open Access Journals (Sweden)

    Mohassel Payman

    2016-04-01

    Full Text Available Secure Two-Party Computation (2PC protocols allow two parties to compute a function of their private inputs without revealing any information besides the output of the computation. There exist low cost general-purpose protocols for semi-honest parties that can be efficiently executed even on smartphones. However, for the case of malicious parties, current 2PC protocols are significantly less efficient, limiting their use to more resourceful devices. In this work we present an efficient 2PC protocol that is secure against malicious parties and is light enough to be used on mobile phones. The protocol is an adaptation of the protocol of Nielsen et al. (Crypto, 2012 to the Server-Aided setting, a natural relaxation of the plain model for secure computation that allows the parties to interact with a server (e.g., a cloud who is assumed not to collude with any of the parties. Our protocol has two stages: In an offline stage - where no party knows which function is to be computed, nor who else is participating - each party interacts with the server and downloads a file. Later, in the online stage, when two parties decide to execute a 2PC together, they can use the files they have downloaded earlier to execute the computation with cost that is lower than the currently best semi-honest 2PC protocols. We show an implementation of our protocol for Android mobile phones, discuss several optimizations and report on its evaluation for various circuits. For example, the online stage for evaluating a single AES circuit requires only 2.5 seconds and can be further reduced to 1 second (amortized time with multiple executions.

  12. Seismic Adequacy Review of PC012 SCEs that are Potential Seismic Hazards with PC3 SCEs - CVD Facility

    International Nuclear Information System (INIS)

    OCOMA, E.C.

    1999-01-01

    This document provides seismic adequacy review of PCO12 Systems, Components L Equipment anchorage that are potential seismic interaction hazards with PC3 SCEs during a Design Basis Earthquake. The PCO12 items are identified in the Safety Equipment List as 3/1 SCEs

  13. The comparison of CAP88-PC version 2.0 versus CAP88-PC version 1.0

    International Nuclear Information System (INIS)

    Yakubovich, B.A.; Klee, K.O.; Palmer, C.R.; Spotts, P.B.

    1997-12-01

    40 CFR Part 61 (Subpart H of the NESHAP) requires DOE facilities to use approved sampling procedures, computer models, or other approved procedures when calculating Effective Dose Equivalent (EDE) values to members of the public. Currently version 1.0 of the approved computer model CAP88-PC is used to calculate EDE values. The DOE has upgraded the CAP88-PC software to version 2.0. This version provides simplified data entry, better printing characteristics, the use of a mouse, and other features. The DOE has developed and released version 2.0 for testing and comment. This new software is a WINDOWS based application that offers a new graphical user interface with new utilities for preparing and managing population and weather data, and several new decay chains. The program also allows the user to view results before printing. This document describes a test that confirmed CAP88-PC version 2.0 generates results comparable to the original version of the CAP88-PC program

  14. Surface-type nonvolatile electric memory elements based on organic-on-organic CuPc-H2Pc heterojunction

    International Nuclear Information System (INIS)

    Karimov, Khasan S.; Muqeet Rehman, M.; Zameer Abbas, S.; Ahmad, Zubair; Touati, Farid; Mahroof-Tahir, M.

    2015-01-01

    A novel surface-type nonvolatile electric memory elements based on organic semiconductors CuPc and H 2 Pc are fabricated by vacuum deposition of the CuPc and H 2 Pc films on preliminary deposited metallic (Ag and Cu) electrodes. The gap between Ag and Cu electrodes is 30–40 μm. For the current–voltage (I–V) characteristics the memory effect, switching effect, and negative differential resistance regions are observed. The switching mechanism is attributed to the electric-field-induced charge transfer. As a result the device switches from a low to a high-conductivity state and then back to a low conductivity state if the opposite polarity voltage is applied. The ratio of resistance at the high resistance state to that at the low resistance state is equal to 120–150. Under the switching condition, the electric current increases ∼ 80–100 times. A comparison between the forward and reverse I–V characteristics shows the presence of rectifying behavior. (paper)

  15. Development of lowdrag aerodynamically stable with indented processing; Indento kako wo hodokoshita seishin keburu no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    Hojo, T.; Yamazaki, S.; Okada, H.

    1998-10-29

    A wind-resistant design of cables for large cable-stayed bridges is required as a measure against rain-wind induced vibration. In such bridges, many cables are arranged in a short pitch, which causes a large drag force on the cables. Therefore, reduction of drag force on cables is essential for rationalizing bridge design, as well as restraint of vibration. This paper describes studies on a new cable having both a low drag co-efficient force and rain-vibration suppressing effects. Through many investigations using wind tunnel tests, an indented cable was developed as a countermeasure against rain-wind induced vibration, and finally it was applied to the Tatara Bridge which is the largest cable-stayed bridge in the world. (author)

  16. Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis.

    Science.gov (United States)

    Kelavkar, U P; Nixon, J B; Cohen, C; Dillehay, D; Eling, T E; Badr, K F

    2001-11-01

    The effect of overexpression of 15-lipoxygenase-1 (15-LO-1) was studied in the human prostate cancer cell line, PC-3. Stable PC-3 cell lines were generated by transfection with 15-LO-1-sense (15-LOS), 15-LO-1-antisense (15-LOAS) or vector (Zeo) and selection with Zeocin. After characterization by RT-PCR, western and HPLC, a PC3-15LOS clone was selected that possessed 10-fold 15-LO-1 enzyme activity compared with parental PC-3 cells. The PC3-15LOAS clone displayed little or no 15-LO-1 activity. These PC-3 cell lines were characterized for properties of tumorigenesis. The proliferation rates of the cell lines were as follows: PC3-15LOS > PC-3 = PC3-Zeo > PC3-15LOAS. Addition of a specific 15-LO-1 inhibitor, PD146176, caused a dose-dependent inhibition of proliferation in vitro. Overexpression of 15-LO-1 also caused [(3)H]thymidine incorporation to increase by 4.0-fold (P < 0.01). Compared with parental and PC-3-Zeo cells, PC3-15LOS enhanced whereas PC3-15LOAS reduced the ability of PC-3 cells to grow in an anchorage-independent manner, as assessed by colony formation in soft agar. These data suggested a pro-tumorigenic role for 15-LO-1 in PC-3 cells in vitro. Therefore, to clarify the role of 15-LO-1 in vivo, the effect of 15-LO-1 expression on the growth of tumors in nude mice was investigated. The PC-3 cell lines were inoculated subcutaneously into athymic nude mice. The frequency of tumor formation was increased and the sizes of the tumors formed were much larger in the PC3-15LOS compared with PC3-15LOAS, parental PC-3 and PC-3-Zeo cells. Immunohistochemistry for 15-LO-1 confirmed expression throughout the duration of the experiment. The expression of factor VIII, an angiogenesis marker, in tumor sections was increased in tumors derived from PC3-15LOS cells and decreased in those from PC3-15LOAS cells compared with tumors from parental or Zeo cells. These data further supported the evaluation by ELISA of vascular endothelial growth factor (VEGF) secretion by PC-3

  17. Prostate carcinoma (PC) - an organ-related specific pathological neoplasm; Prostatakarzinom (PC) - eine organspezifische Neoplasie aus der Sicht der Pathologie

    Energy Technology Data Exchange (ETDEWEB)

    Massmann, J.; Funk, A. [Gemeinschaftspraxis Pathologie Massmann-Funk-Dettmar, Muenchen (Germany); Altwein, J. [Krankenhaus der Barmherzigen Brueder, Muenchen (Germany); Praetorius, M.

    2003-06-01

    The organ- and tumour-related specific characteristics of prostate carcinoma (PC) are presented in an overview under various aspects. It is the key for understanding pathological changes, including PC, to consider the subdivision of the prostate into anatomically and functionally distinguishable zones, especially the transitional zone (TZ) and the peripheral zone (PZ). The pseudoneoplastic hyperplasia of the TZ, combined with inflammatory consequences and age-related changes, forms a differential diagnostic challenge to both clinico-radiological diagnosis and macroscopic and microscopic examination. High-degree prostatic intra-epithelial neoplasia (PIN III) and atypical adenomatous hyperplasia (AAH) are presented as precursor lesions of PC with varying significance and assessment. Moreover, there are discussed the following characteristic features of PC: localisation types, focality, volume, progression, double-graduation according to Gleason, tumour stage, and prognosis. The most important prognosis factors of PC (category I) include the categories of the TNM system, such as stage, surgical marginal situation, degree and also the preoperative PSA level as a (poor) substitute for the tumour volume. Potential prognosis parameters (category II) show the tumour volume and the DNS ploidy, while there continues to exist a large number of non-established parameters (category III). The prognostic validity of the pathological examinations depends, on the one hand, on the tissue extent (needle biopsy, transurethral resection (TURP), so-called simple prostatectomy, radical prostatectomy (RPE)) and the prostate zones covered. On the other hand, the prognostic certainty also depends on the tumour-adequate macroscopic and microscopic assessment of an RPE that can only be a partial or complete handling in transversal large-area sections. (orig.) [German] Die organ- und tumorspezifischen Besonderheiten des Prostatakarzinoms (PC) werden in einer Uebersicht unter verschiedenen

  18. CARES/PC - CERAMICS ANALYSIS AND RELIABILITY EVALUATION OF STRUCTURES

    Science.gov (United States)

    Szatmary, S. A.

    1994-01-01

    The beneficial properties of structural ceramics include their high-temperature strength, light weight, hardness, and corrosion and oxidation resistance. For advanced heat engines, ceramics have demonstrated functional abilities at temperatures well beyond the operational limits of metals. This is offset by the fact that ceramic materials tend to be brittle. When a load is applied, their lack of significant plastic deformation causes the material to crack at microscopic flaws, destroying the component. CARES/PC performs statistical analysis of data obtained from the fracture of simple, uniaxial tensile or flexural specimens and estimates the Weibull and Batdorf material parameters from this data. CARES/PC is a subset of the program CARES (COSMIC program number LEW-15168) which calculates the fast-fracture reliability or failure probability of ceramic components utilizing the Batdorf and Weibull models to describe the effects of multi-axial stress states on material strength. CARES additionally requires that the ceramic structure be modeled by a finite element program such as MSC/NASTRAN or ANSYS. The more limited CARES/PC does not perform fast-fracture reliability estimation of components. CARES/PC estimates ceramic material properties from uniaxial tensile or from three- and four-point bend bar data. In general, the parameters are obtained from the fracture stresses of many specimens (30 or more are recommended) whose geometry and loading configurations are held constant. Parameter estimation can be performed for single or multiple failure modes by using the least-squares analysis or the maximum likelihood method. Kolmogorov-Smirnov and Anderson-Darling goodness-of-fit tests measure the accuracy of the hypothesis that the fracture data comes from a population with a distribution specified by the estimated Weibull parameters. Ninety-percent confidence intervals on the Weibull parameters and the unbiased value of the shape parameter for complete samples are provided

  19. METHANE de-NOX for Utility PC Boilers

    Energy Technology Data Exchange (ETDEWEB)

    Bruce Bryan; Serguei Nester; Joseph Rabovitser; Stan Wohadlo

    2005-09-30

    The overall project objective is the development and validation of an innovative combustion system, based on a novel coal preheating concept prior to combustion, that can reduce NO{sub x} emissions to 0.15 lb/million Btu or less on utility pulverized coal (PC) boilers. This NO{sub x} reduction should be achieved without loss of boiler efficiency or operating stability, and at more than 25% lower levelized cost than state-of-the-art SCR technology. A further objective is to ready technology for full-scale commercial deployment to meet the market demand for NO{sub x} reduction technologies. Over half of the electric power generated in the U.S. is produced by coal combustion, and more than 80% of these units utilize PC combustion technology. Conventional measures for NOx reduction in PC combustion processes rely on combustion and post-combustion modifications. A variety of combustion-based NO{sub x} reduction technologies are in use today, including low-NO{sub x} burners (LNBs), flue gas recirculation (FGR), air staging, and natural gas or other fuel reburning. Selective non-catalytic reduction (SNCR) and selective catalytic reduction (SCR) are post-combustion techniques. NO{sub x} reduction effectiveness from these technologies ranges from 30 to 60% and up to 90-93% for SCR. Typically, older wall-fired PC burner units produce NO{sub x} emissions in the range of 0.8-1.6 lb/million Btu. Low-NO{sub x} burner systems, using combinations of fuel staging within the burner and air staging by introduction of overfire air in the boiler, can reduce NO{sub x} emissions by 50-60%. This approach alone is not sufficient to meet the desired 0.15 lb/million Btu NO{sub x} standard with a range of coals and boiler loads. Furthermore, the heavy reliance on overfire air can lead to increased slagging and corrosion in furnaces, particularly with higher-sulfur coals, when LNBs are operated at sub-stoichiometric conditions to reduce fuel-derived NOx in the flame. Therefore, it is desirable

  20. Electronic transitions and band offsets in C60:SubPc and C60:MgPc on MoO3 studied by modulated surface photovoltage spectroscopy

    International Nuclear Information System (INIS)

    Fengler, S.; Dittrich, Th.; Rusu, M.

    2015-01-01

    Electronic transitions at interfaces between MoO 3 layers and organic layers of C 60 , SubPc, MgPc, and nano-composite layers of SubPc:C 60 and MgPc:C 60 have been studied by modulated surface photovoltage (SPV) spectroscopy. For all systems, time dependent and modulated SPV signals pointed to dissociation of excitons at the MoO 3 /organic layer interfaces with a separation of holes towards MoO 3 . The highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) gaps (E HL ) of C 60 , SubPc, and MgPc and the effective E HL of SubPc:C 60 and MgPc:C 60 were measured. The offsets between the LUMO (ΔE L ) or HOMO (ΔE H ) bands were obtained with high precision and amounted to 0.33 or 0.73 eV for SubPc:C 60 , respectively, and to −0.33 or 0.67 eV for MgPc:C 60 , respectively. Exponential tails below E HL and most pronounced sub-bandgap transitions were characterized and ascribed to disorder and transitions from HOMO bands to unoccupied defect states

  1. Substrate analysis of the Pneumocystis carinii protein kinases PcCbk1 and PcSte20 using yeast proteome microarrays provides a novel method for Pneumocystis signalling biology.

    Science.gov (United States)

    Kottom, Theodore J; Limper, Andrew H

    2011-10-01

    Pneumocystis carinii (Pc) undergoes morphological transitions between cysts and trophic forms. We have previously described two Pc serine/threonine kinases, termed PcCbk1 and PcSte20, with PcSte20 belonging to a family of kinases involved in yeast mating, while PcCbk1 is a member of a group of protein kinases involved in regulation of cell cycle, shape, and proliferation. As Pc remains genetically intractable, knowledge on specific substrates phosphorylated by these kinases remains limited. Utilizing the phylogenetic relatedness of Pc to Saccharomyces cerevisiae, we interrogated a yeast proteome microarray containing >4000 purified protein based peptides, leading to the identification of 18 potential PcCbk1 and 15 PcSte20 substrates (Z-score > 3.0). A number of these potential protein substrates are involved in bud site selection, polarized growth, and response to mating α factor and pseudohyphal and invasive growth. Full-length open reading frames suggested by the PcCbk1 and PcSte20 protoarrays were amplified and expressed. These five proteins were used as substrates for PcCbk1 or PcSte20, with each being highly phosphorylated by the respective kinase. Finally, to demonstrate the utility of this method to identify novel PcCbk1 and PcSte20 substrates, we analysed DNA sequence data from the partially complete Pc genome database and detected partial sequence information of potential PcCbk1 kinase substrates PcPxl1 and PcInt1. We additionally identified the potential PcSte20 kinase substrate PcBdf2. Full-length Pc substrates were cloned and expressed in yeast, and shown to be phosphorylated by the respective Pc kinases. In conclusion, the yeast protein microarray represents a novel crossover technique for identifying unique potential Pc kinase substrates. Copyright © 2011 John Wiley & Sons, Ltd.

  2. Tablet PC Enabled Body Sensor System for Rural Telehealth Applications

    Directory of Open Access Journals (Sweden)

    Nitha V. Panicker

    2016-01-01

    Full Text Available Telehealth systems benefit from the rapid growth of mobile communication technology for measuring physiological signals. Development and validation of a tablet PC enabled noninvasive body sensor system for rural telehealth application are discussed in this paper. This system includes real time continuous collection of physiological parameters (blood pressure, pulse rate, and temperature and fall detection of a patient with the help of a body sensor unit and wireless transmission of the acquired information to a tablet PC handled by the medical staff in a Primary Health Center (PHC. Abnormal conditions are automatically identified and alert messages are given to the medical officer in real time. Clinical validation is performed in a real environment and found to be successful. Bland-Altman analysis is carried out to validate the wrist blood pressure sensor used. The system works well for all measurements.

  3. PC communication world and Yiyagi 5.3

    International Nuclear Information System (INIS)

    1992-11-01

    This book is comprised of four parts about Yiyagi 5.3. It describes how to use Yiyagi 5.3 : the way to save 5.3 into floppy disk and Hard disk, to store modem, how to communicate with Hitel and PC-serve in the first part, how to use the various function : function key, control key, alt key, text editor of Yiyagi 5.3 and mouse in the second part, to be good at using communication : Modem, screen control, RS-232C and Null Modem, script and Multitasking in the third part. It has an appendix about compression and decompression of file, BBS list, PC application such as VGA graphic, UNIX/ XENIX and DOS, RS-232C and Modem and GR.exe.

  4. Pocket PC-based portable gamma-ray spectrometer

    Directory of Open Access Journals (Sweden)

    Kamontip Ploykrachang

    2011-04-01

    Full Text Available A portable gamma-ray spectrometer based on a Pocket PC has been developed. A 12-bit pipeline analog-to-digitalconverter (ADC associated with an implemented pulse height histogram function on field programmable gate array (FPGAoperating at 15 MHz is employed for pulse height analysis from built-in pulse amplifier. The system, which interfaces withthe Pocket PC via an enhanced RS-232 serial port under the microcontroller facilitation, is utilized for spectrum acquisition,display and analysis. The pulse height analysis capability of the system was tested and it was found that the ADC integralnonlinearity of ±0.45% was obtained with the throughput rate at 160 kcps. The overall system performance was tested usinga PIN photodiode-CsI(Tl crystal coupled scintillation detector and gamma standard radioactive sources of Cs-137 andCo-60. Low cost and the compact system size as a result of the implemented logical function are also discussed.

  5. PC analysis of stochastic differential equations driven by Wiener noise

    KAUST Repository

    Le Maitre, Olivier

    2015-03-01

    A polynomial chaos (PC) analysis with stochastic expansion coefficients is proposed for stochastic differential equations driven by additive or multiplicative Wiener noise. It is shown that for this setting, a Galerkin formalism naturally leads to the definition of a hierarchy of stochastic differential equations governing the evolution of the PC modes. Under the mild assumption that the Wiener and uncertain parameters can be treated as independent random variables, it is also shown that the Galerkin formalism naturally separates parametric uncertainty and stochastic forcing dependences. This enables us to perform an orthogonal decomposition of the process variance, and consequently identify contributions arising from the uncertainty in parameters, the stochastic forcing, and a coupled term. Insight gained from this decomposition is illustrated in light of implementation to simplified linear and non-linear problems; the case of a stochastic bifurcation is also considered.

  6. CuPc/C60 heterojunction thin film optoelectronic devices

    International Nuclear Information System (INIS)

    Murtaza, Imran; Karimov, Khasan S.; Qazi, Ibrahim

    2010-01-01

    The optoelectronic properties of heterojunction thin film devices with ITO/CuPc/C 60 /Al structure have been investigated by analyzing their current-voltage characteristics, optical absorption and photocurrent. In this organic photovoltaic device, CuPc acts as an optically active layer, C 60 as an electron-transporting layer and ITO and Al as electrodes. It is observed that, under illumination, excitons are formed, which subsequently drift towards the interface with C 60 , where an internal electric field is present. The excitons that reach the interface are subsequently dissociated into free charge carriers due to the electric field present at the interface. The experimental results show that in this device the total current density is a function of injected carriers at the electrode-organic semiconductor surface, the leakage current through the organic layer and collected photogenerated current that results from the effective dissociation of excitons. (semiconductor devices)

  7. Radioimmunoassay data processing program for IBM PC computers

    International Nuclear Information System (INIS)

    1989-06-01

    The Medical Applications Section of the International Atomic Energy Agency (IAEA) has previously developed several programs for use on the Hewlett-Packard HP-41C programmable calculator to facilitate better quality control in radioimmunoassay through improved data processing. The program described in this document is designed for off-line analysis using an IBM PC (or compatible) for counting data from standards and unknown specimens (i.e. for analysis of counting data previously recorded by a counter), together with internal quality control (IQC) data both within and between batch. The greater computing power of the IBM PC has enabled the imprecision profile and IQC control curves which were unavailable on the HP-41C version. It is intended that the program would make available good data processing capability to laboratories having limited financial resources and serious problems of quality control. 3 refs

  8. EZVIDEO, DISSPLA Graphics Software Simulation on IBM PC

    International Nuclear Information System (INIS)

    1991-01-01

    1 - Description of program or function: EZVIDEO simulates a subset of the DISSPLA plotting package to make plots on the IBM PC screen. Screen dumps can also be made to an attached LaserJet or Epson printer to make hard copy without using terminal emulators. The forerunner of EZVIDEO was called EZPLOT. 2 - Method of solution: The subroutines in the EZVIDEO system are based on the Hewlett Packard HP 9000 simulation of DISSPLA. These routines manipulate the pen movements on the screen and are also capable of capturing these same movements so that a hardcopy can be made to dot matrix or laser printer. 3 - Restrictions on the complexity of the problem: For plotting on the IBM PC, the plotting emulator PCPLOT is needed

  9. Flexible missile autopilot design studies with PC-MATLAB/386

    Science.gov (United States)

    Ruth, Michael J.

    1989-01-01

    Development of a responsive, high-bandwidth missile autopilot for airframes which have structural modes of unusually low frequency presents a challenging design task. Such systems are viable candidates for modern, state-space control design methods. The PC-MATLAB interactive software package provides an environment well-suited to the development of candidate linear control laws for flexible missile autopilots. The strengths of MATLAB include: (1) exceptionally high speed (MATLAB's version for 80386-based PC's offers benchmarks approaching minicomputer and mainframe performance); (2) ability to handle large design models of several hundred degrees of freedom, if necessary; and (3) broad extensibility through user-defined functions. To characterize MATLAB capabilities, a simplified design example is presented. This involves interactive definition of an observer-based state-space compensator for a flexible missile autopilot design task. MATLAB capabilities and limitations, in the context of this design task, are then summarized.

  10. Conversion from 8800 to 8800PC - Evaluation and experience

    International Nuclear Information System (INIS)

    Miner, A.E.; Lawson, B.J.

    1998-01-01

    Though a final version of the software is pending the 8800PC operating system host computer is a welcomed change from the old Digital (DEC) host computer. The 8800PC host computer uses the Windows NT operating system and has proven to be very user friendly. Descriptive window messages replace the cryptic coding of the DEC host. Though numerous electrical components were replaced, system calibration remained constant. Calibrated Thermoluminescent (TL) output from a randomly selected 8815 field card was measured before and after the upgrade. The % difference, when comparing calibrated output from an upgraded reader to the non upgraded reader, ranged from 0.2 to 3%. The most disappointing aspect of the upgrade experience was the lag time between hardware installation and software completion

  11. Introduction of the EISA-PC into existing fusion experiments

    International Nuclear Information System (INIS)

    Tenten, W.; Bertschinger, G.; Mueller, K.D.; Reinhart, P.; Rongen, F.

    1995-01-01

    A general problem in the data acquisition field in fusion research is the lack of sufficient local memory for the storage of information acquired during a single discharge. While it is absolutely necessary to keep these data locally before transferring them to a central node, there has been a steadily increasing demand for more capacity. The introduction of an EISA-Personal-Computer with its vast and cheap memory resources is presenting a very interesting solution for the upgrade of existing installations and the design of new experiments. An innovative PC interface using Programmable Logic techniques was developed that allows easy and fast integration of a PC into an existing experimental setup. Several typical applications of this method are presented, that are of special interest for fusion experiments. (orig.)

  12. A PC based control system for the CERN ISOLDE separators

    International Nuclear Information System (INIS)

    Billinge, R.; Bret, A.; Deloose, I.; Pace, A.; Shering, G.

    1992-01-01

    The control system of the two isotope separators of CERN, named ISOLDE, is being completely redesigned with the goal of having a flexible, high performance and inexpensive system. A new architecture that makes heavy use of the commercial software and hardware available for the huge Personal Computer (PC) market is being implemented on the 1700 geographically distributed control channels of the separators. 8 MS-DOS TM i386-based PCs with about 80 acquisition/control boards are used to access the equipments while 3 other PCs running Microsoft Windows TM and Microsoft Excel TM are used as consoles, the whole through a Novell TM Local Area Network with a PC Disk Server used as a database. This paper describes the interesting solutions found and discusses the reduced programming work load and costs that are expected to build the system before the start of the separators in March 1992. (author)

  13. Metal Detector By Using PIC Microcontroller Interfacing With PC

    Directory of Open Access Journals (Sweden)

    Yin Min Theint

    2015-06-01

    Full Text Available Abstract This system proposes metal detector by using PIC microcontroller interfacing with PC. The system uses PIC microcontroller as the main controller whether the detected metal is ferrous metal or non-ferrous metal. Among various types of metal sensors and various types of metal detecting technologies concentric type induction coil sensor and VLF very low frequency metal detecting technology are used in this system. This system consists of two configurations Hardware configuration and Software configuration. The hardware components include induction coil sensors which senses the frequency changes of metal a PIC microcontroller personal computer PC buzzer light emitting diode LED and webcam. The software configuration includes a program controller interface. PIC MikroCprogramming language is used to implement the control system. This control system is based on the PIC 16F887 microcontroller.This system is mainly used in mining and high security places such as airport plaza shopping mall and governmental buildings.

  14. Superoxide dismutase in radioresistant PC-3 human prostate carcinoma cells

    International Nuclear Information System (INIS)

    Prokopovic, J.; Adzic M; Niciforovic, A.; Vucic, V.; Zaric, B.; Radojcic, M. B.

    2006-01-01

    The molecular mechanism of gamma-ionizing radiation (IR) resistance of human prostate cancer cells PC-3 is not known. Since low-LET-IR effects are primarily achieved through generation of reactive oxygen species (ROS), IR-induced expression of ROS-metabolizing antioxidant enzymes, Mn- and CuZn-superoxide dismutase (Mn- and CuZnSOD) and catalase (CAT), and their upstream regulator transcription factor NFκB was followed. Significant elevation of both SODs was found in cells irradiated with 10- and 20 Gy, while CAT and NFκB expression was unchanged. Since, such conditions lead to accumulation of H 2 O 2 , it is concluded that radioresistance of PC-3 cells may emerge from positive feed-forward vicious circle established between H 2 O 2 activation of NFκB and elevated MnSOD activity. (author)

  15. Toward the optimization of PC-based training

    Science.gov (United States)

    Cho, Kohei; Murai, Shunji

    Since 1992, the National Space Development Agency of Japan (NASDA) and the Economic and Social Commission for Asia and the Pacific (ESCAP) have been co-organising the Regional Remote Sensing Seminar on Tropical Ecosystem Management (Program Chairman: Prof. Shunji Murai) every year in some country in Asia. In these seminars, the members of the ISPRS Working Group VI/2 'Computer Assisted Teaching' have been performing a PC-based hands-on-training on remote sensing and GIS for beginners. The main objective of the training was to transfer not only knowledge but also the technology of remote sensing and GIS to the beginners. The software and CD-ROM data set provided at the training were well designed not only for training but also for practical data analysis. This paper presents an outline of the training and discusses the optimisation of PC-based training for remote sensing and GIS.

  16. A embedded Linux system based on PowerPC

    International Nuclear Information System (INIS)

    Ye Mei; Zhao Jingwei; Chu Yuanping

    2006-01-01

    The authors will introduce a Embedded Linux System based on PowerPC as well as the base method on how to establish the system. The goal of the system is to build a test system of VMEbus device. It also can be used to setup the small data acquisition and control system. Two types of compiler are provided by the developer system according to the features of the system and the Power PC. At the top of the article some typical embedded Operation system will be introduced and the features of different system will be provided. And then the method on how to build a embedded Linux system as well as the key technique will be discussed in detail. Finally a successful read-write example will be given based on the test system. (authors)

  17. Kondrashov Gammas. PC database for gamma-rays from radionuclides. Summary documentation

    International Nuclear Information System (INIS)

    Lemmel, H.D.

    1996-01-01

    A PC database by V. Kondrashov containing energies and yields of gamma-rays from radionuclides is described. The PC diskette is available from the IAEA Nuclear Data Section, cost free upon request. (author)

  18. Efficient Techniques for Formal Verification of PowerPC 750 Executables, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — We will develop an efficient tool for formal verification of PowerPC 750 executables. The PowerPC 750 architecture is used in the radiation-hardened RAD750...

  19. A scalable PC-based parallel computer for lattice QCD

    International Nuclear Information System (INIS)

    Fodor, Z.; Katz, S.D.; Pappa, G.

    2003-01-01

    A PC-based parallel computer for medium/large scale lattice QCD simulations is suggested. The Eoetvoes Univ., Inst. Theor. Phys. cluster consists of 137 Intel P4-1.7GHz nodes. Gigabit Ethernet cards are used for nearest neighbor communication in a two-dimensional mesh. The sustained performance for dynamical staggered (wilson) quarks on large lattices is around 70(110) GFlops. The exceptional price/performance ratio is below $1/Mflop

  20. A scalable PC-based parallel computer for lattice QCD

    International Nuclear Information System (INIS)

    Fodor, Z.; Papp, G.

    2002-09-01

    A PC-based parallel computer for medium/large scale lattice QCD simulations is suggested. The Eoetvoes Univ., Inst. Theor. Phys. cluster consists of 137 Intel P4-1.7 GHz nodes. Gigabit Ethernet cards are used for nearest neighbor communication in a two-dimensional mesh. The sustained performance for dynamical staggered(wilson) quarks on large lattices is around 70(110) GFlops. The exceptional price/performance ratio is below $1/Mflop. (orig.)

  1. Code for plant identification (KKS) key in PC version

    International Nuclear Information System (INIS)

    Pannenbaecker, K.

    1991-01-01

    The plant identification system (KKS) as a common development of german plant operators, erection firms and also power plant oriented organisations have decisively influenced the technical-organizing activities of planning and erections as operations and maintenance of all kind of power plants. Fundamentals are three key parts, operation, armatures and function keys. Their management and application is executed by a plantidentification-key code in a PC version, which is briefly described in this report. (orig.) [de

  2. Bifenthrin inhibits neurite outgrowth in differentiating PC12 cells.

    Science.gov (United States)

    Tran, Van; Hoffman, Natalie; Mofunanaya, Adaobi; Pryor, Stephen C; Ojugbele, Olutosin; McLaughlin, Ashlea; Gibson, Lydia; Bonventre, Josephine A; Flynn, Katherine; Weeks, Benjamin S

    2006-02-01

    Bifenthrin is a third generation member of the synthetic pyrethroid family of insecticides. As a new pesticide within a relatively new class of pesticides, bifenthrin is considered relatively safe. Here, we used the PC12 neuronal cell line to examine the effect of bifenthrin on the formation of neurites and the potential developmental neurotoxicity of this pesticide. PC12 cells were exposed to varying concentrations of technical grade bifenthrin or Ortho Home Defense. Cell viability was determined using the AlmarBlue Toxicity Assay. Nontoxic concentrations of these chemicals were concomitantly with nerve growth factor and neurite outgrowth was assessed. Ortho Home Defense preparation reduced PC12 cell viability by approximately 50% and 70% at dilutions that correlate to bifenthrin concentrations of 10(-5) M and 10(-4) M, respectively. In contrast, technical grade bifenthrin, was not toxic to PC12 cells at 10(-3) M, which was the highest concentration tested that was soluble. At "nontoxic" concentrations of 10(-7) M and 10(-6) M, the Ortho Home Defense inhibited nerve growth factor-mediated neurite outgrowth by 30% and 55% respectively. Furthermore the nontoxic concentrations of technical grade bifenthrin of 10(-6) M and 10(-3) M inhibited neurite outgrowth by approximately 35% and 75% respectively. These data suggest that the toxicity of the Ortho Home Defense preparation was due to the "inert" additives in the preparation and not the bifenthrin itself. Further, these data suggest that, even in the absence of overt toxicity, bifenthrin may have deleterious effects to developing nervous system.

  3. Teaching mathematics in the PC lab - the students' viewpoints

    Science.gov (United States)

    Schmidt, Karsten; Köhler, Anke

    2013-04-01

    The Matrix Algebra portion of the intermediate mathematics course at the Schmalkalden University Faculty of Business and Economics has been moved from a traditional classroom setting to a technology-based setting in the PC lab. A Computer Algebra System license was acquired that also allows its use on the students' own PCs. A survey was carried out to analyse the students' attitudes towards the use of technology in mathematics teaching.

  4. Application of miniature heat pipe for notebook PC cooling

    Energy Technology Data Exchange (ETDEWEB)

    Moon, S.H.; Hwang, G.; Choy, T.G. [Electronics and Telecommunications research Institute, Taejeon (Korea)

    2001-06-01

    Miniature heat pipe(MHP) with woven-wired wick was used to cool the CPU of a notebook PC. The pipe with circular cross-section was pressed and bent for packaging the MHP into a notebook PC with very limited compact packaging space. A cross-sectional area of the pipe is reduced about 30% as the MHP with 4 mm diameter is pressed to 2 mm thickness. In the present study a performance test has been performed in order to review varying of operating performance according to pressed thickness variation and heat dissipation capacity of MHP cooling module that is packaged on a notebook PC. New wick type was considered for overcoming low heat transfer limit when MHP is pressed to thin-plate. The limiting thickness of pressing is shown to be within the range of 2 mm {approx} 2.5 mm through the performance test with varying the pressing thickness. When the wall thickness of 0.4 mm is reduced to 0.25 mm for minimizing conductive thermal resistance through the wall of heat pipe, heat transfer limit and thermal resistance of MHP were improved about 10%. In the meantime, it is shown that the thermal resistance and heat transfer limit for the MHP with central wick type are higher than those of MHP with existing wick types. The results of performance test for MHP cooling modules with woven-wired wick to cool notebook PC shows the stability as cooling system since T{sub j}(Temperature of Processor Junction) satisfy a demand condition of 0 {approx} 100 deg.C under 11.5 W of CPU heat. (author). 6 refs., 7 figs.

  5. Falling PC Solitaire Cards: An Open-Inquiry Approach

    Science.gov (United States)

    Gonzalez-Espada, Wilson J.

    2012-01-01

    Many of us have played the PC Solitaire game that comes as standard software in many computers. Although I am not a great player, occasionally I win a game or two. The game celebrates my accomplishment by pushing the cards forward, one at a time, falling gracefully in what appears to look like a parabolic path in a drag-free environment. One day,…

  6. Practical Pocket PC Application w/Biometric Security

    Science.gov (United States)

    Logan, Julian

    2004-01-01

    I work in the Flight Software Engineering Branch, where we provide design and development of embedded real-time software applications for flight and supporting ground systems to support the NASA Aeronautics and Space Programs. In addition, this branch evaluates, develops and implements new technologies for embedded real-time systems, and maintains a laboratory for applications of embedded technology. The majority of microchips that are used in modern society have been programmed using embedded technology. These small chips can be found in microwaves, calculators, home security systems, cell phones and more. My assignment this summer entails working with an iPAQ HP 5500 Pocket PC. This top-of-the-line hand-held device is one of the first mobile PC's to introduce biometric security capabilities. Biometric security, in this case a fingerprint authentication system, is on the edge of technology as far as securing information. The benefits of fingerprint authentication are enormous. The most significant of them are that it is extremely difficult to reproduce someone else's fingerprint, and it is equally difficult to lose or forget your own fingerprint as opposed to a password or pin number. One of my goals for this summer is to integrate this technology with another Pocket PC application. The second task for the summer is to develop a simple application that provides an Astronaut EVA (Extravehicular Activity) Log Book capability. The Astronaut EVA Log Book is what an astronaut would use to report the status of field missions, crew physical health, successes, future plans, etc. My goal is to develop a user interface into which these data fields can be entered and stored. The applications that I am developing are created using eMbedded Visual C++ 4.0 with the Pocket PC 2003 Software Development Kit provided by Microsoft.

  7. Quantal release of ATP from clusters of PC12 cells.

    Science.gov (United States)

    Fabbro, Alessandra; Skorinkin, Andrei; Grandolfo, Micaela; Nistri, Andrea; Giniatullin, Rashid

    2004-10-15

    Although ATP is important for intercellular communication, little is known about the mechanism of endogenous ATP release due to a dearth of suitable models. Using PC12 cells known to express the P2X2 subtype of ATP receptors and to store ATP with catecholamines inside dense-core vesicles, we found that clusters of PC12 cells cultured for 3-7 days generated small transient inward currents (STICs) after an inward current elicited by exogenous ATP. The amplitude of STICs in individual cells correlated with the peak amplitude of ATP-induced currents. STICs appeared as asynchronous responses (approximately 20 pA average amplitude) for 1-20 s and were investigated with a combination of patch clamping, Ca2+ imaging, biochemistry and electron microscopy. Comparable STICs were produced by focal KCl pulses and were dependent on extracellular Ca2+. STICs were abolished by the P2X antagonist PPADS and potentiated by Zn2+, suggesting they were mediated by P2X2 receptor activation. The highest probability of observing STICs was after the peak of intracellular Ca2+ increase caused by KCl. Biochemical measurements indicated that KCl application induced a significant release of ATP from PC12 cells. Electron microscopy studies showed narrow clefts without 'synaptic-like' densities between clustered cells. Our data suggest that STICs were caused by quantal release of endogenous ATP by depolarized PC12 cells in close juxtaposition to the recorded cell. Thus, STICs may be a new experimental model to characterize the physiology of vesicular release of ATP and to study the kinetics and pharmacology of P2X2 receptor-mediated quantal currents.

  8. PCNuDAT a PC Nuclear Data program

    International Nuclear Information System (INIS)

    Kinsey, R.R.

    1998-01-01

    The PC program PCNuDat is described which displays nuclear radioactive decay data and thermal cross section data. It requires 45 Megabytes (reduced version of PCNuDat requires 3 Megabytes) of disc space and can be obtained through Internet FTP or WWW from U.S. Nuclear Data Center or Nuclear Data Section of the IAEA. It can be obtained also on CD-ROM upon request sent to Nuclear Data Section. (author)

  9. Metal Detector By Using PIC Microcontroller Interfacing With PC

    OpenAIRE

    Yin Min Theint; Myo Maung Maung; Hla Myo Tun

    2015-01-01

    Abstract This system proposes metal detector by using PIC microcontroller interfacing with PC. The system uses PIC microcontroller as the main controller whether the detected metal is ferrous metal or non-ferrous metal. Among various types of metal sensors and various types of metal detecting technologies concentric type induction coil sensor and VLF very low frequency metal detecting technology are used in this system. This system consists of two configurations Hardware configuration and Sof...

  10. PC based alpha, beta and gamma counting system

    International Nuclear Information System (INIS)

    Bhattacharya, S.; Gopalakrishnan, K.R.; Bairi, B.R.

    1992-01-01

    In the field of radiation protection and safety a large number of samples have to be assayed for estimation of their radioactivity at various stages in nuclear fuel. A PC based alpha, beta and gamma counting system has been designed for the above application. The system is fully automatic and requires minimum of operator intervention. The main units in the system are detector and pulse processing electronics, sample changer and assembly and IBM PC interface and supporting software. The main function of interface is to control the sample changer which is basically loading and unloading of sample, data acquisition and further processing by software. The pulses from detector are analysed in a pulse shape discriminator. A pulse identified as an alpha, beta or gamma event is converted to digital pulse. These digital pulses are accumulated in the three channels on PC interface each corresponding to alpha, beta and gamma. The sample movements are controlled by interface depending upon sample position. The software has been developed so as to maintain user friendliness and convenience of the operator. Various selection modes for parameters and operation of system provide lot of flexibility in operation of the system. (author). 1 fig

  11. Tablet PC interaction with digital micromirror device (DMD)

    Science.gov (United States)

    Refai, Hakki H.; Dahshan, Mostafa H.; Sluss, James J., Jr.

    2007-02-01

    Digital light processing (DLP) is an innovative display technology that uses an optical switch array, known as a digital micromirror device (DMD), which allows digital control of light. To date, DMDs have been used primarily as high-speed spatial light modulators for projector applications. A tablet PC is a notebook or slate-shaped mobile PC. Its touch screen or digitizing tablet technology allows the user to operate the notebook with a stylus or digital pen instead of using a keyboard or mouse. In this paper, we describe an interface solution that translates any sketch on the tablet PC screen to an identical mirror-copy over the cross-section of the DMD micromirrors such that the image of the sketch can be projected onto a special screen. An algorithm has been created to control each single micromirror of the hundreds of thousands of micromirrors that cover the DMD surface. We demonstrate the successful application of a DMD to a high-speed two-dimensional (2D) scanning environment, acquiring the data from the tablet screen and launching its contents to the projection screen; with very high accuracy up to 13.68 μm x 13.68 μm of mirror pitch.

  12. The reactor physics computer programs in PC's era

    International Nuclear Information System (INIS)

    Nainer, O.; Serghiuta, D.

    1995-01-01

    The main objective of reactor physics analysis is the evaluation of flux and power distribution over the reactor core. For CANDU reactors sophisticated computer programs, such as FMDP and RFSP, were developed 20 years ago for mainframe computers. These programs were adapted to work on workstations with UNIX or DOS, but they lack a feature that could improve their use and that is 'user friendly'. For using these programs the users need to deal with a great amount of information contained in sophisticated files. To modify a model is a great challenge. First of all, it is necessary to bear in mind all the geometrical dimensions and accordingly, to modify the core model to match the new requirements. All this must be done in a line input file. For a DOS platform, using an average performance PC system, could it be possible: to represent and modify all the geometrical and physical parameters in a meaningful way, on screen, using an intuitive graphic user interface; to reduce the real time elapsed in order to perform complex fuel-management analysis 'at home'; to avoid the rewrite of the mainframe version of the program? The author's answer is a fuel-management computer package operating on PC, 3 time faster than on a CDC-Cyber 830 mainframe one (486DX/33MHz/8MbRAM) or 20 time faster (Pentium-PC), respectively. (author). 5 refs., 1 tab., 5 figs

  13. Feasibility study of BES data processing and physics analysis on a PC/Linux platform

    International Nuclear Information System (INIS)

    Rong Gang; He Kanglin; Zhao Jiawei; Heng Yuekun; Zhang Chun

    1999-01-01

    The authors report a feasibility study of off-line BES data processing (data reconstruction and Detector simulation) on a PC/Linux platform and an application of the PC/Linux system in D/Ds physics analysis. The authors compared the results obtained from the PC/Linux with that from HP workstation. It shows that PC/Linux platform can do BES data offline analysis as good as UNIX workstation do, but it is much powerful and economical

  14. The USL NASA PC R and D project: General specifications of objectives

    Science.gov (United States)

    Dominick, Wayne D. (Editor)

    1984-01-01

    Given here are the general specifications of the objectives of the University of Southwestern Louisiana Data Base Management System (USL/DBMS) NASA PC R and D Project, a project initiated to address future R and D issues related to PC-based processing environments acquired pursuant to the NASA contract work; namely, the IBM PC/XT systems.

  15. File list: InP.Prs.50.AllAg.PC-3 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Prs.50.AllAg.PC-3 hg19 Input control Prostate PC-3 SRX539667,SRX084520,SRX43319...9,SRX433195,SRX1021636,SRX1021637,SRX181768,SRX540851 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.Prs.50.AllAg.PC-3.bed ...

  16. Multi-satellite study of the excitation of Pc3 and Pc4-5 ULF waves and their penetration across the plasmapause during the 2003 Halloween superstorm

    Science.gov (United States)

    Balasis, G.; Daglis, I. A.; Mann, I. R.; Papadimitriou, C.; Zesta, E.; Georgiou, M.; Haagmans, R.; Tsinganos, K.

    2015-10-01

    We use multi-satellite and ground-based magnetic data to investigate the concurrent characteristics of Pc3 (22-100 mHz) and Pc4-5 (1-22 mHz) ultra-low-frequency (ULF) waves on the 31 October 2003 during the Halloween magnetic superstorm. ULF waves are seen in the Earth's magnetosphere, topside ionosphere, and Earth's surface, enabling an examination of their propagation characteristics. We employ a time-frequency analysis technique and examine data from when the Cluster and CHAMP spacecraft were in good local time (LT) conjunction near the dayside noon-midnight meridian. We find clear evidence of the excitation of both Pc3 and Pc4-5 waves, but more significantly we find a clear separation in the L shell of occurrence of the Pc4-5 and Pc3 waves in the equatorial inner magnetosphere, separated by the density gradients at the plasmapause boundary layer. A key finding of the wavelet spectral analysis of data collected from the Geotail, Cluster, and CHAMP spacecraft and the CARISMA and GIMA magnetometer networks was a remarkably clear transition of the waves' frequency into dominance in a higher-frequency regime within the Pc3 range. Analysis of the local field line resonance frequency suggests that the separation of the Pc4-5 and Pc3 emissions across the plasmapause is consistent with the structure of the inhomogeneous field line resonance Alfvén continuum. The Pc4-5 waves are consistent with direct excitation by the solar wind in the plasma trough, as well as Pc3 wave absorption in the plasmasphere following excitation by upstream waves originating at the bow shock in the local noon sector. However, despite good solar wind coverage, our study was not able to unambiguously identify a clear explanation for the sharp universal time (UT) onset of the discrete frequency and large-amplitude Pc3 wave power.

  17. Multi-satellite study of the excitation of Pc3 and Pc4-5 ULF waves and their penetration across the plasmapause during the 2003 Halloween superstorm

    Directory of Open Access Journals (Sweden)

    G. Balasis

    2015-10-01

    Full Text Available We use multi-satellite and ground-based magnetic data to investigate the concurrent characteristics of Pc3 (22–100 mHz and Pc4-5 (1–22 mHz ultra-low-frequency (ULF waves on the 31 October 2003 during the Halloween magnetic superstorm. ULF waves are seen in the Earth's magnetosphere, topside ionosphere, and Earth's surface, enabling an examination of their propagation characteristics. We employ a time–frequency analysis technique and examine data from when the Cluster and CHAMP spacecraft were in good local time (LT conjunction near the dayside noon–midnight meridian. We find clear evidence of the excitation of both Pc3 and Pc4-5 waves, but more significantly we find a clear separation in the L shell of occurrence of the Pc4-5 and Pc3 waves in the equatorial inner magnetosphere, separated by the density gradients at the plasmapause boundary layer. A key finding of the wavelet spectral analysis of data collected from the Geotail, Cluster, and CHAMP spacecraft and the CARISMA and GIMA magnetometer networks was a remarkably clear transition of the waves' frequency into dominance in a higher-frequency regime within the Pc3 range. Analysis of the local field line resonance frequency suggests that the separation of the Pc4-5 and Pc3 emissions across the plasmapause is consistent with the structure of the inhomogeneous field line resonance Alfvén continuum. The Pc4-5 waves are consistent with direct excitation by the solar wind in the plasma trough, as well as Pc3 wave absorption in the plasmasphere following excitation by upstream waves originating at the bow shock in the local noon sector. However, despite good solar wind coverage, our study was not able to unambiguously identify a clear explanation for the sharp universal time (UT onset of the discrete frequency and large-amplitude Pc3 wave power.

  18. Static and Dynamic Energetic Disorders in the C 60 , PC 61 BM, C 70 , and PC 71 BM Fullerenes

    KAUST Repository

    Tummala, Naga Rajesh

    2015-09-17

    We use a combination of molecular dynamics simulations and density functional theory calculations to investigate the energetic disorder in fullerene systems. We show that the energetic disorder evaluated from an ensemble average contains contributions of both static origin (time-independent, due to loose packing) and dynamic origin (time-dependent, due to electron-vibration interactions). In order to differentiate between these two contributions, we compare the results obtained from an ensemble average approach with those derived from a time average approach. It is found that in both amorphous C60 and C70 bulk systems, the degrees of static and dynamic disorder are comparable, while in the amorphous PC61BM and PC71BM systems, static disorder is about twice as large as dynamic disorder. © 2015 American Chemical Society.

  19. An overview of the evaluation plan for PC/MISI: PC-based Multiple Information System Interface

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Lim, Bee Lee; Hall, Philip P.

    1985-01-01

    An initial evaluation plan for the personal computer multiple information system interface (PC/MISI) project is discussed. The document is intend to be used as a blueprint for the evaluation of this system. Each objective of the design project is discussed along with the evaluation parameters and methodology to be used in the evaluation of the implementation's achievement of those objectives. The potential of the system for research activities related to more general aspects of information retrieval is also discussed.

  20. Code for plant identification (KKS) key in PC version. KKS-Schluessel-Programm in PC-Version

    Energy Technology Data Exchange (ETDEWEB)

    Pannenbaecker, K. (GABO Gesellschaft fuer Ablauforganisation und Informationsverarbeitung mbH, Erlangen (Germany) GABO Gesellschaft fuer Ablauforganisation und Informationsverarbeitung mbH, Muenchen (Germany))

    1991-11-01

    The plant identification system (KKS) as a common development of german plant operators, erection firms and also power plant oriented organisations have decisively influenced the technical-organizing activities of planning and erections as operations and maintenance of all kind of power plants. Fundamentals are three key parts, operation, armatures and function keys. Their management and application is executed by a plantidentification-key code in a PC version, which is briefly described in this report. (orig.).

  1. PC-CIMACT. A near real time materials accountancy software package for use on an IBM or compatible PC

    International Nuclear Information System (INIS)

    Williams, D.E.; Gale, R.

    1990-03-01

    This report describes the 'PC-CIMACT' Near Real Time Materials Accountancy computer package. It has been derived from 'CIMACT', which is in daily use at the UKAEA's Dounreay Nuclear Power Establishment. The scope of the package is presented, together with the statistical analyses it encompasses. Several of the analyses are illustrated by the treatment of data from a simulated reprocessing campaign. A user guide providing detailed instructions is also included. (author)

  2. Ion and solvent diffusion and ion conduction of PC-DEC and PC-DME binary solvent electrolytes of LiN(SO2CF3)2

    International Nuclear Information System (INIS)

    Hayamizu, Kikuko; Aihara, Yuichi

    2004-01-01

    Two binary mixed solvent systems typically used for lithium batteries were studied by measuring the self-diffusion coefficients of the solvent, lithium ion and anion, independently by using the multi-nuclear pulsed field-gradient spin-echo (PGSE) 1 H, 7 Li and 19 F NMR method. One system was propylene carbonate (PC) and diethyl carbonate (DEC) system and the other binary system was PC and 1,2-dimethoxyethane (DME), and the lithium salt used was LiN(SO 2 CF 3 ) 2 (LiTFSI). The relative ratio of the PC was changed from zero (pure DME and DEC) to 100% (pure PC) in the DME-PC and the DEC-PC systems, respectively. The self-diffusion coefficients of the solvents were measured with and without the lithium salt, and the two solvents had almost the same diffusion coefficient in the DEC-PC system, while DME diffused faster than PC in the DME-PC system. In the electrolytes the solvents diffused the fastest, followed by the anion with the lithium ion diffusing the slowest. The degree of ion dissociation was estimated for each electrolyte by comparing the ionic conductivities estimated from the ion diffusion and those measured directly by the electrochemical method

  3. Troubleshooting and Maintaining Your PC All-in-One Desk Reference For Dummies

    CERN Document Server

    Gookin, Dan

    2009-01-01

    Maintaining a PC is important, and troubleshooting a PC can be a challenge. Dan Gookin is great at explaining how to handle common PC problems, and he's provided a complete, plain-English manual in Troubleshooting & Maintaining Your PC All-in-One For Dummies. Liberally laced with Dan's famous humor and clear instructions, Troubleshooting & Maintaining Your PC All-in-One For Dummies is divided into six minibooks covering hardware, software, laptops, Internet, networking, and maintenance. Each one gives you some background on what causes common problems, to help you understand what's wrong as we

  4. Nasal associated lymphoid tissue of the Syrian golden hamster expresses high levels of PrPC.

    Directory of Open Access Journals (Sweden)

    Melissa D Clouse

    Full Text Available The key event in the pathogenesis of the transmissible spongiform encephalopathies is a template-dependent misfolding event where an infectious isoform of the prion protein (PrPSc comes into contact with native prion protein (PrPC and changes its conformation to PrPSc. In many extraneurally inoculated models of prion disease this PrPC misfolding event occurs in lymphoid tissues prior to neuroinvasion. The primary objective of this study was to compare levels of total PrPC in hamster lymphoid tissues involved in the early pathogenesis of prion disease. Lymphoid tissues were collected from golden Syrian hamsters and Western blot analysis was performed to quantify PrPC levels. PrPC immunohistochemistry (IHC of paraffin embedded tissue sections was performed to identify PrPC distribution in tissues of the lymphoreticular system. Nasal associated lymphoid tissue contained the highest amount of total PrPC followed by Peyer's patches, mesenteric and submandibular lymph nodes, and spleen. The relative levels of PrPC expression in IHC processed tissue correlated strongly with the Western blot data, with high levels of PrPC corresponding with a higher percentage of PrPC positive B cell follicles. High levels of PrPC in lymphoid tissues closely associated with the nasal cavity could contribute to the relative increased efficiency of the nasal route of entry of prions, compared to other routes of infection.

  5. Nasal associated lymphoid tissue of the Syrian golden hamster expresses high levels of PrPC.

    Science.gov (United States)

    Clouse, Melissa D; Shikiya, Ronald A; Bartz, Jason C; Kincaid, Anthony E

    2015-01-01

    The key event in the pathogenesis of the transmissible spongiform encephalopathies is a template-dependent misfolding event where an infectious isoform of the prion protein (PrPSc) comes into contact with native prion protein (PrPC) and changes its conformation to PrPSc. In many extraneurally inoculated models of prion disease this PrPC misfolding event occurs in lymphoid tissues prior to neuroinvasion. The primary objective of this study was to compare levels of total PrPC in hamster lymphoid tissues involved in the early pathogenesis of prion disease. Lymphoid tissues were collected from golden Syrian hamsters and Western blot analysis was performed to quantify PrPC levels. PrPC immunohistochemistry (IHC) of paraffin embedded tissue sections was performed to identify PrPC distribution in tissues of the lymphoreticular system. Nasal associated lymphoid tissue contained the highest amount of total PrPC followed by Peyer's patches, mesenteric and submandibular lymph nodes, and spleen. The relative levels of PrPC expression in IHC processed tissue correlated strongly with the Western blot data, with high levels of PrPC corresponding with a higher percentage of PrPC positive B cell follicles. High levels of PrPC in lymphoid tissues closely associated with the nasal cavity could contribute to the relative increased efficiency of the nasal route of entry of prions, compared to other routes of infection.

  6. Dielectric and Energy Storage Properties of the Heterogeneous P(VDF-HFP)/PC Composite Films

    Science.gov (United States)

    Zhao, Xiaojia; Peng, Guirong; Zhan, Zaiji

    2017-12-01

    Polymer-based materials with a high discharge energy and low energy loss have attracted considerable attention for energy storage applications. A new class of polymer-based composite films composed of amorphous polycarbonate (PC) and poly(vinylidene fluoride-hexafluoropropylene) [P(VDF-HFP)] has been fabricated by simply solution blending followed by thermal treatment under vacuum. The results show that the diameter of the spherical phase for PC and the melting temperature of P(VDF-HFP) increase, and the crystallinity and crystallization temperature of P(VDF-HFP) decrease with increasing PC content. The phase transition from the polar β phase to weak polarity γ phase is induced by PC addition. Moreover, the Curie temperature of the P(VDF-HFP)/PC composite films shifts to a lower temperature. With the addition of PC, the permittivity, polarization and discharge energy of the P(VDF-HFP)/PC composite films slightly decrease. However, the energy loss is significantly reduced.

  7. CLIPS - C LANGUAGE INTEGRATED PRODUCTION SYSTEM (IBM PC VERSION)

    Science.gov (United States)

    Riley, G.

    1994-01-01

    The C Language Integrated Production System, CLIPS, is a shell for developing expert systems. It is designed to allow artificial intelligence research, development, and delivery on conventional computers. The primary design goals for CLIPS are portability, efficiency, and functionality. For these reasons, the program is written in C. CLIPS meets or outperforms most micro- and minicomputer based artificial intelligence tools. CLIPS is a forward chaining rule-based language. The program contains an inference engine and a language syntax that provide a framework for the construction of an expert system. It also includes tools for debugging an application. CLIPS is based on the Rete algorithm, which enables very efficient pattern matching. The collection of conditions and actions to be taken if the conditions are met is constructed into a rule network. As facts are asserted either prior to or during a session, CLIPS pattern-matches the number of fields. Wildcards and variables are supported for both single and multiple fields. CLIPS syntax allows the inclusion of externally defined functions (outside functions which are written in a language other than CLIPS). CLIPS itself can be embedded in a program such that the expert system is available as a simple subroutine call. Advanced features found in CLIPS version 4.3 include an integrated microEMACS editor, the ability to generate C source code from a CLIPS rule base to produce a dedicated executable, binary load and save capabilities for CLIPS rule bases, and the utility program CRSV (Cross-Reference, Style, and Verification) designed to facilitate the development and maintenance of large rule bases. Five machine versions are available. Each machine version includes the source and the executable for that machine. The UNIX version includes the source and binaries for IBM RS/6000, Sun3 series, and Sun4 series computers. The UNIX, DEC VAX, and DEC RISC Workstation versions are line oriented. The PC version and the Macintosh

  8. PC based Thyroid uptake system for the National Health System

    International Nuclear Information System (INIS)

    Arista Romeo, Eduardo; Ateche Diaz, Raul; Alonso Abad, Dolores

    2003-01-01

    a measurement detection system is presented to be used in Iodine Thyroid Uptake Studies. It consists of three elements the detector with its collimator, a blind measurement module and the application software. The measurements module communications through a RS-232 serial interface to the PC where the applications software Detect resides. The software was designed according to the principles ob object oriented programming using C++ language. It automatically fixes spectrometric measurement parameters and besides patient measurement also performs statistical analysis of a batch of samples, It possesses a Paradox database with all information of measured patients and an on line help with the system options

  9. An inexpensive PC-based ion linac control system

    International Nuclear Information System (INIS)

    Hamm, M.E.; Potter, J.M.

    1991-01-01

    A turn-key PC-based control system has been developed for the AccSys line of compact ion linear accelerators and rf power amplifiers. The control interface is based on the DZERO Rack Monitor Module, developed at Fermi National Accelerator Laboratory, communicating with a Ballard Technology MIL-STD-1553B controller board in a 286 or 386 personal computer. This cost effective and easy to operate control system features real-time control and monitoring of the linac/rf amplifier and can be customized for automatic start-up and unattended operation

  10. Compressional Pc5 type pulsations in the morningside plasma sheet

    Energy Technology Data Exchange (ETDEWEB)

    Vaivads, A.; Baumjohann, W.; Haerendel, G.; Nakamura, R.; Kucharek, H.; Klecker, B. [Max-Planck-Institut fuer Extraterrestrische Physik, Garching (Germany); Lessard, M.R. [Dartmouth Coll., Hanover, NH (United States). Thayer School of Engineering; Kistler, L.M. [New Hampshire Univ., Durham (United States). Space Science Center; Mukai, T.; Nishida, A. [Institute of Space and Astronautical Science, Sagamihara, Kanagawa (Japan)

    2001-03-01

    We study compressional pulsations in Pc5 frequency range observed in the dawn-side at distances of about 10 R{sub E}, close to the magnetic equator. We use data obtained during two events of conjunctions between Equator-S and Geotail: 1000-1700 UT on 9 March 1998, and 0200-0600 UT on 25 April 1998. In both events, pulsations are observed after substorm activity. The pulsations are antisymmetric with respect to the equatorial plane (even mode), and move eastward with phase velocity close to plasma velocity. The pulsations tend to be pressure balanced. We also discuss possible generation mechanisms of the pulsations. (orig.)

  11. Cooling performance of a notebook PC mounted with heat spreader

    Energy Technology Data Exchange (ETDEWEB)

    Noh, H.K. [Electronics and Telecommunications Research Institute, Taejeon (Korea); Lim, K.B. [Hanbat National University, Taejeon (Korea); Park, M.H. [Korea Power Engineering Company (Korea)

    2001-06-01

    Parametric study to investigate the cooling performance of a notebook PC mounted with heat spreader has been numerically performed. Two case of air-blowing and air-exhaust at inlet were tested. The cooling effect on parameters such as, inlet velocities in the cases of air-blowing and air-exhaust, materials of heat spreader, and CPU powers were simulated for two cases. Cooling performance in the case of air-blowing was better than the case of air-exhaust. (author). 9 refs., 7 figs., 5 tabs.

  12. PC interfacing using Centronics, RS232 and game ports

    CERN Document Server

    An, Pei

    1998-01-01

    The main links with your PC and the outside world are the centronic port, used for connecting the printer, the RS232 port, used for the mouse, and the games port for a joystick. This book explores how these input/output (I/O) ports can be put to use through a range of other interfacing applications. This is especially useful for laptop and palmtop PCs which cannot be fitted with internal I/O cards. A novel approach is taken by this book, combining the hardware through which the ports can be explored, and the software programming needed to carry out a range of experiments.Circuits are p

  13. Isobaric PVT Behavior of Poly(Carbonate) (PC)

    Science.gov (United States)

    Grassia, Luigi; D'Amore, Alberto

    2010-06-01

    The scaling law for relaxation times, τ(V,T) = ℑ(TVγ), recently proposed by Casalini and Roland, is utilized in the framework of KAHR (Kovacs Aklonis Hutchinson and Ramos) phenomenological theory. With this approach it is shown that the Pressure, Volume, Temperature (PVT) data obtained on Poly(carbonate)(PC) can be reliably predicted, in the region of the alpha relaxation, by using only two fitting parameters, namely: the relaxation time in the reference condition, τg, and the fractional exponent, β that describes the dispersion of the alpha relaxation.

  14. The operating software of the PHAST PC-MCA Card

    International Nuclear Information System (INIS)

    Mukhopadhyay, P.K.

    2001-01-01

    The operating software of the PHAST PC-MCA Card provides powerful hardware support and data analysis features. Spectrum stabilisation is supported. A periodic spectrum saving option helps recovery of usable data in case of power failure. This feature can also be used for decay studies. Spectra acquired in several other types of MCA cards may be read for offline analysis. Non-linear least square fitting of the peaks in the entire spectrum with exponential tailed model is possible in a single operation. Nuclides may be identified and activity determined by matching energies with the gamma energy library of the program. Two component decay analysis at multiple energies is possible. (author)

  15. Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression.

    Directory of Open Access Journals (Sweden)

    Kayla A Boortz

    Full Text Available Elevated fasting blood glucose (FBG has been associated with increased risk for development of type 2 diabetes. Single nucleotide polymorphisms (SNPs in G6PC2 are the most important common determinants of variations in FBG in humans. Studies using G6pc2 knockout mice suggest that G6pc2 regulates the glucose sensitivity of insulin secretion. G6PC2 and the related G6PC1 and G6PC3 genes encode glucose-6-phosphatase catalytic subunits. This study describes a functional analysis of 22 non-synonymous G6PC2 SNPs, that alter amino acids that are conserved in human G6PC1, mouse G6pc1 and mouse G6pc2, with the goal of identifying variants that potentially affect G6PC2 activity/expression. Published data suggest strong conservation of catalytically important amino acids between all four proteins and the related G6PC3 isoform. Because human G6PC2 has very low glucose-6-phosphatase activity we used an indirect approach, examining the effect of these SNPs on mouse G6pc1 activity. Using a novel in situ functional assay for glucose-6-phosphatase activity we demonstrate that the amino acid changes associated with the human G6PC2 rs144254880 (Arg79Gln, rs149663725 (Gly114Arg and rs2232326 (Ser324Pro SNPs reduce mouse G6pc1 enzyme activity without affecting protein expression. The Arg79Gln variant alters an amino acid mutation of which, in G6PC1, has previously been shown to cause glycogen storage disease type 1a. We also demonstrate that the rs368382511 (Gly8Glu, rs138726309 (His177Tyr, rs2232323 (Tyr207Ser rs374055555 (Arg293Trp, rs2232326 (Ser324Pro, rs137857125 (Pro313Leu and rs2232327 (Pro340Leu SNPs confer decreased G6PC2 protein expression. In summary, these studies identify multiple G6PC2 variants that have the potential to be associated with altered FBG in humans.

  16. High-level PC-based laser system modeling

    Science.gov (United States)

    Taylor, Michael S.

    1991-05-01

    Since the inception of the Strategic Defense Initiative (SDI) there have been a multitude of comparison studies done in an attempt to evaluate the effectiveness and relative sizes of complementary, and sometimes competitive, laser weapon systems. It became more and more apparent that what the systems analyst needed was not only a fast, but a cost effective way to perform high-level trade studies. In the present investigation, a general procedure is presented for the development of PC-based algorithmic systems models for laser systems. This procedure points out all of the major issues that should be addressed in the design and development of such a model. Issues addressed include defining the problem to be modeled, defining a strategy for development, and finally, effective use of the model once developed. Being a general procedure, it will allow a systems analyst to develop a model to meet specific needs. To illustrate this method of model development, a description of the Strategic Defense Simulation - Design To (SDS-DT) model developed and used by Science Applications International Corporation (SAIC) is presented. SDS-DT is a menu-driven, fast executing, PC-based program that can be used to either calculate performance, weight, volume, and cost values for a particular design or, alternatively, to run parametrics on particular system parameters to perhaps optimize a design.

  17. GVTRAN-PC-a steam generator transient simulator

    International Nuclear Information System (INIS)

    Nakata, H.

    1991-02-01

    Since an accuracy and inexpensive analysis capability is one of the desirable requirement in the reactor licensing procedure and, also, in instances when a severe accident sequence and its degree of severity must be estimated, the present work tries partially to fulfill that present need by developing a fast and acceptably accurate simulator. The present report presents the methodology utilized to develop GVTRAN-PC program, the steam generator simulation program for the microcomputer environment, which possess a capability to reproduce the experimental data with accuracies comparable to those of the mainframe simulators. The methodology is based on the mass and energy conservation in the control volumes which represents both the primary and the secondary fluid in the U-tube steam generator. The quasi-static momentum conservation in the secondary fluid control volumes determines in a semi-iterative scheme the liquid level in the feedwater chamber. The implementation of the moving boundary technique has allowed the tracking of the boundary of bulk boiling region with the utilization of a reduced number of control volumes in the tube region. GVTRAN-PC program has been tested against typical PWR pump trip transient experimental data and the calculation results showed good agreement in most representative parameters, viz. the feedchamber water-level and the steam dome pressure. (author)

  18. Pheochromocytoma (PC12 Cell Response on Mechanobactericidal Titanium Surfaces

    Directory of Open Access Journals (Sweden)

    Jason V. Wandiyanto

    2018-04-01

    Full Text Available Titanium is a biocompatible material that is frequently used for making implantable medical devices. Nanoengineering of the surface is the common method for increasing material biocompatibility, and while the nanostructured materials are well-known to represent attractive substrata for eukaryotic cells, very little information has been documented about the interaction between mammalian cells and bactericidal nanostructured surfaces. In this study, we investigated the effect of bactericidal titanium nanostructures on PC12 cell attachment and differentiation—a cell line which has become a widely used in vitro model to study neuronal differentiation. The effects of the nanostructures on the cells were then compared to effects observed when the cells were placed in contact with non-structured titanium. It was found that bactericidal nanostructured surfaces enhanced the attachment of neuron-like cells. In addition, the PC12 cells were able to differentiate on nanostructured surfaces, while the cells on non-structured surfaces were not able to do so. These promising results demonstrate the potential application of bactericidal nanostructured surfaces in biomedical applications such as cochlear and neuronal implants.

  19. On the quiet-time Pc 5 pulsation events (spacequakes)

    International Nuclear Information System (INIS)

    Gupta, J.C.; Niblett, E.R.

    1979-01-01

    A quiet-time Pc 5 event (designated Spacequake) of March 18, 1974, first noted on the Fort Churchill magnetogram, was studied using global data. Its amplitude was found to be largest in the northern part of the auroral zone and its period seemed to increase with latitude. The clockwise polarization of the event noted at Baker Lake and higher latitudes changed to counterclockwise at Fort Churchill in X-Y, X-Z and Y-Z planes. The resonance of a field line (L approximately 10) excited due to an instability of the Kelvin-Helmholtz type may have given rise to the observed event. It is conjectured that the cause of instability at this altitude was internal convection of the magnetosphere. Similar quiet-time events from four Canadian observatories were selected from approximately 11 years of magnetograms and their statistical analysis revealed that (i) occurrences maximised near dawn and dusk (ii) the amplitude-latitude profile peaked at Great Whale River (L approximately 6.67), (iii) periods increased with increasing geomagnetic latitudes, (iv) a large number of events occurred in January, February and March every year, and (v) frequency of occurrence increased with increasing sunspot numbers. Comparison of these results with those available in the literature from analyses of satellite data clearly indicate that quiet-time Pc 5 events (Spacequakes) originate in the outer magnetosphere. (author)

  20. PC-AT to gamma camera interface ANUGAMI-S

    International Nuclear Information System (INIS)

    Bhattacharya, Sadhana; Gopalakrishnan, K.R.

    1997-01-01

    PC-AT to gamma camera interface is an image acquisition system used in nuclear medicine centres and hospitals. The interface hardware and acquisition software have been designed and developed to meet most of the routine clinical applications using gamma camera. The state of the art design of the interface provides quality improvement in addition to image acquisition, by applying on-line uniformity correction which is very essential for gamma camera applications in nuclear medicine. The improvement in the quality of the image has been achieved by image acquisition in positionally varying and sliding energy window. It supports all acquisition modes viz. static, dynamic and gated acquisition modes with and without uniformity correction. The user interface provides the acquisition in various user selectable frame sizes, orientation and colour palettes. A complete emulation of camera console has been provided along with persistence scope and acquisition parameter display. It is a universal system which provides a modern, cost effective and easily maintainable solution for interfacing any gamma camera to PC or upgradation of analog gamma camera. (author). 4 refs., 3 figs

  1. Pc based RF control system for the Vincy cyclotron

    International Nuclear Information System (INIS)

    Samardzic, B.J.; Drndarevic, V.R.

    1999-01-01

    The concept and design procedure for the RF control system of the VINCY cyclotron are described. Special attention has been paid to the choice of computer support of this system. The merits and limitations of the chosen solution have been analyzed. A PC type computer has been selected as the platform for performing the functions of initiation, control, and supervision of the RF system. The integration of the hardware is carried out by direct connection to the PC bus via standard communication interfaces. The system software operates under a graphic oriented Windows operating system applying the modern concept of virtual instrumentation. The application of this concept allowed considerable simplification of the operator-RF system interaction and resulted in additional flexibility of the software to further extensions or modifications of the system. The selected open architecture of the computer platform allows a simple and economic upgrading of the realized system in accordance with future requirements. Tests of the realized RF control system prototype are in progress. (authors)

  2. A PC version of the Monte Carlo criticality code OMEGA

    International Nuclear Information System (INIS)

    Seifert, E.

    1996-05-01

    A description of the PC version of the Monte Carlo criticality code OMEGA is given. The report contains a general description of the code together with a detailed input description. Furthermore, some examples are given illustrating the generation of an input file. The main field of application is the calculation of the criticality of arrangements of fissionable material. Geometrically complicated arrangements that often appear inside and outside a reactor, e.g. in a fuel storage or transport container, can be considered essentially without geometrical approximations. For example, the real geometry of assemblies containing hexagonal or square lattice structures can be described in full detail. Moreover, the code can be used for special investigations in the field of reactor physics and neutron transport. Many years of practical experience and comparison with reference cases have shown that the code together with the built-in data libraries gives reliable results. OMEGA is completely independent on other widely used criticality codes (KENO, MCNP, etc.), concerning programming and the data base. It is a good practice to run difficult criticality safety problems by different independent codes in order to mutually verify the results. In this way, OMEGA can be used as a redundant code within the family of criticality codes. An advantage of OMEGA is the short calculation time: A typical criticality safety application takes only a few minutes on a Pentium PC. Therefore, the influence of parameter variations can simply be investigated by running many variants of a problem. (orig.)

  3. Fuzzy Based PC-PUSH in CR-MANETs

    Directory of Open Access Journals (Sweden)

    S. Nejatian

    2014-01-01

    Full Text Available In cognitive radio (CR, the secondary user (SU needs to hand off its ongoing communication to an idle channel in order to avoid interference to the primary user (PU. Spectrum hand off issue becomes challenging in CR mobile ad hoc networks (CR-MANETs because of the uncertainty in spectrum availability, broad range of spectrum bands and lack of central entity. The purpose of this study is to design a unified spectrum handoff (USH scheme for CR-MANETs that considers the spectrum heterogeneity and its availability over time and space. A local flow hand off is performed when spectrum hand off cannot be carried out due to the SUs mobility. To improve further USH, preemptive unified spectrum handoff (PUSH algorithm is proposed in which two different preemptive hand off threshold regions are defined. The PUSH algorithm also predicts the cognitive link availability considering the PU interference boundary. Although the PUSH scheme improves the hand off performance, the number of spectrum hand offs due to the PU activity should be reduced in this scheme. Therefore, the PC-PUSH (Power Controller-PUSH scheme is proposed in which the fuzzy logic is used to improve the PUSH in terms of the number of spectrum handoffs because of the PU activity. The PC-PUSH decreases the interference to the PUs, while reducing the number of spectrum handoffs. The results show that the proposed scheme improves the link maintenance probability, decreases the hand off delay, and reduces the number of spectrum handoffs.

  4. Nuclear data retrieval for PC applications, PCNuDat

    International Nuclear Information System (INIS)

    Kinsey, R.R.

    1996-01-01

    The PCNuDat program for IBM-PC compatibles is similar to the NuDat program available through the NNDC Online Nuclear Data Service. They provide a user with access to nuclear data in a convenient and menu driven system. This data is useful in both basic and applied research. The nuclear base used by NuDat is extracted from several data bases maintained at the National Nuclear Data Center (NNDC). The program is an extended DOS program which uses 32 bit addressing. It can run in a DOS window on all the current Windows operating systems. The program and its data base are currently available on both a CD-ROM or electronically over the Internet. Electronic access can be made through the NNDC's Web home page. The files may also be FTP'd from the public area under the [pc prog] directory on bnlnd2.dne.bnl.gov. The CD-ROM version also contains the Nuclear Science References (NSR) data base and its retrieval program, Papyrus NSR

  5. From a UNIX to a PC Based SCADA System

    CERN Document Server

    Momal, F

    1999-01-01

    In order to facilitate the development of supervisory applications involved in slow process control (such as cryogenic control), the LHC/IAS Group (Equipment Controls Group) opted, a few years ago, for an industrial SCADA package which runs on UNIXÒ platforms. However, to reduce costs and following market trends, it has been decided to move over to a PC-based package. Several processes relating to the testing of the prototypes of the LHC magnets are already controlled in this way. However, it was still necessary to provide all the services previously available to the users, for example, data archiving in central databases, real-time access through the Web, automatic GSM calls, etc. This paper presents the advantages and drawbacks of a PC-based package versus a Unix-based system. It also lists the criteria used in the market survey to arrive at the final selection, as well as, the overall architecture, highlighting the developments needed to integrate the package into the global computing environment.

  6. Found a USB stick? Go and infect your PC!

    CERN Document Server

    Computer Security Team

    2012-01-01

    Err. Wait. Please no! USB sticks are not innocent little things. They can quickly mutate into malicious nasty beasts! Just in the recent past, at least two physics experiments were suffering as their control and data acquisition PCs, respectively, were infected by USB sticks holding malicious code. A bit longer ago, a series of laptops were infected at a 2008 computing conference as an infected USB stick made its tour around. Bad luck for those who ran a Windows operating system and inserted that stick…   So, you found a USB stick in the cafeteria? Take care. If this were a lollipop, you wouldn’t just pick it up and lick it, would you? So beware of USB sticks whose origin or previous usage you don’t know. They might infect your PC once plugged in. In order to be on the safe side, accept and share only USB sticks whose owner you trust. Run up-to-date anti-virus software on your PC, make sure that its operating system is patched...

  7. Pengaruh bahan pengisi serat kaca terhadap sifat fisik dan kristalinitas polipaduan PC/ABS

    Directory of Open Access Journals (Sweden)

    Dwi Wahini Nurhajati

    2017-06-01

    Full Text Available This research aimed to determine the effects of the addition of glass fibers on the physical and crystallinity properties of PC/ABS polyblends. The ratio of PC/ABS used in this research was 75/25, while the addition of glass fibers ranged from 0; 5; 10; to 15 phr (based on the weight of PC/ABS. Polyblends of PC/ABS/glass fibers were prepared in a twin screw extruder. The test results showed that density and tensile strength of PC/ABS polyblends increased with an increase in the glass fiber content. The presence of glass fibers decreased MFI and impact strength of these PC/ABS polyblends. The functional groups were determined by the fourier transform infrared (FTIR spectrophotometer while crystallinity was examined using X-ray diffractometer (XRD.

  8. Is there a link between proprotein convertase PC7 activity and human lipid homeostasis?

    Directory of Open Access Journals (Sweden)

    Johann Guillemot

    2014-01-01

    Full Text Available A genome-wide association study suggested that a R504H mutation in the proprotein convertase PC7 is associated with increased circulating levels of HDL and reduced triglycerides in black Africans. Our present results show that PC7 and PC7-R504H exhibit similar processing of transferrin receptor-1, proSortilin, and apolipoprotein-F. Plasma analyses revealed no change in the lipid profiles, insulin or glucose of wild type and PC7 KO mice. Thus, the R504H mutation does not modify the proteolytic activity of PC7. The mechanisms behind the implication of PC7 in the regulation of human HDL, triglycerides and in modifying the levels of atherogenic small dense LDL remain to be elucidated.

  9. Application of PC-CREAM in the Netherlands. Dose impact due to atmospheric releases

    International Nuclear Information System (INIS)

    Eleveld, H.; Twenhoefel, C.J.W.; Pruppers, M.J.M.

    1999-01-01

    A methodology to assess the radiological impact of routine releases, CREAM, was developed at the National Radiological Protection Board (UK). The software implementation of that methodology to the PC platform, PC-CREAM, has been compared to the Dutch regulation guidelines. The results of the PC-CREAM software and previous RIVM studies are compared for two specific reference situations and eleven naturally occurring radionuclides. The methodology in the submodels in PC-CREAM is also studied and compared to the Dutch regulation guidelines. The assessment of the radiological impact for atmospheric releases using PC-CREAM showed good agreement with the results obtained in previous RIVM studies. Some changes and additions in the methodology are proposed to be able to calculate the radiological impact using PC-CREAM in other relevant reference situations

  10. Reengineering a PC-based System into the Mobile Device Product Line

    DEFF Research Database (Denmark)

    Zhang, Weishan; Jarzabek, Stanislaw; Loughran, Neil

    2003-01-01

    There is a growing demand to port existing PC-based software systems to mobile device platforms. Systems running on mobile devices share basic characteristics with their PC-based counterparts, but differ from them in details of user interfaces, application models, etc. Systems running on mobile...... devices must also perform well using less memory than PC-based systems. Mobile devices themselves are different from each other in many ways, too. We describe how we made an existing PC-based City Guide System available on a wide range of mobile devices, in a cost-effective way. We applied "reengineering...... into a product line architecture" approach to achieve the goal. Our product line architecture facilitates reuse via generation. We generate specific City Guide Systems for target platforms including PC, Pocket PC and other mobile devices, from generic meta-components that form the City Guide System product line...

  11. State of the art of parallel scientific visualization applications on PC clusters; Etat de l'art des applications de visualisation scientifique paralleles sur grappes de PC

    Energy Technology Data Exchange (ETDEWEB)

    Juliachs, M

    2004-07-01

    In this state of the art on parallel scientific visualization applications on PC clusters, we deal with both surface and volume rendering approaches. We first analyze available PC cluster configurations and existing parallel rendering software components for parallel graphics rendering. CEA/DIF has been studying cluster visualization since 2001. This report is part of a study to set up a new visualization research platform. This platform consisting of an eight-node PC cluster under Linux and a tiled display was installed in collaboration with Versailles-Saint-Quentin University in August 2003. (author)

  12. State of the art of parallel scientific visualization applications on PC clusters; Etat de l'art des applications de visualisation scientifique paralleles sur grappes de PC

    Energy Technology Data Exchange (ETDEWEB)

    Juliachs, M

    2004-07-01

    In this state of the art on parallel scientific visualization applications on PC clusters, we deal with both surface and volume rendering approaches. We first analyze available PC cluster configurations and existing parallel rendering software components for parallel graphics rendering. CEA/DIF has been studying cluster visualization since 2001. This report is part of a study to set up a new visualization research platform. This platform consisting of an eight-node PC cluster under Linux and a tiled display was installed in collaboration with Versailles-Saint-Quentin University in August 2003. (author)

  13. Construction of binary status information system using PC network

    International Nuclear Information System (INIS)

    Kurnianto, K.; Azriani, A.; Teddy, S.

    1998-01-01

    Binary status information system is a part of establishing reactor parameter with Pc that function as MPR-30 Process Computer. Binary Alarm system, consist of interface hardware and input binary module terminal, prepare the information that be displayed in text message and graphical form. Monitor software give facilities that binary status of RSG-GAS components can be monitored using computer network (LAN). This program consist of two part : reside in server computer and reside in user computer. Program in server acquire data from interface and than store it in data base (Access file). Than, user computer read this file and display it in Dynamic Process and Instrumentation Diagram. The number of user computer can be more then one because data base was designed for multi-user operation

  14. PC based data system for infrared spectrophotometer PU-9512

    International Nuclear Information System (INIS)

    Ali, Mohd Yakub; Venkiteswaran, S.; Nagar, M.S.

    2000-08-01

    This report summarises the upgrading of an old Infra Red Spectrophotometer using a pc for control, data acquisition, storage and analysis. The hardware link is made through RS232C serial port. The control and data management is achieved through software. A brief account of the facilities provided and versatility of the analysis package which was developed in-house in a user friendly menu driven fashion is given here. This is supported by the analysis and inter comparison of infra red spectra of organic/inorganic reactants and products. It has specific application in synthesis and characterization of new extractants, solvents, actinide and lanthanide complexes and in the study of thermally and radiolytically degraded products. (author)

  15. A PC-based expert system for nondestructive testing

    International Nuclear Information System (INIS)

    Shankar, R.; Williams, R.; Smith, C.; Selby, G.

    1991-01-01

    Rule-based decision logic which can emulate problem-solving expertise of humans is being explored for power plant nondestructive evaluation (NDE) applications. This paper describes an effort underway at the EPRI NDE Center to assist in the interpretation of NDE data acquired by automatic systems during ultrasonic weld examination of boiling-water reactors (BWRs). A personal computer (PC) -based expert system shell was used to encode rules and assemble knowledge to address the discrimination of intergranular stress corrosion cracking (IGSCC) from benign reflectors in the inspection of pipe-to-component welds. The rules attempt to factor in plant inspection history, ultrasonic examination data nd, if available, radiography testing data; a majority of them deal with specific ultrasonic signal temporal and spatial behavior during automatic scanning. The paper describes the efforts in the development of the expert system

  16. Personal Computer (PC) based image processing applied to fluid mechanics

    Science.gov (United States)

    Cho, Y.-C.; Mclachlan, B. G.

    1987-01-01

    A PC based image processing system was employed to determine the instantaneous velocity field of a two-dimensional unsteady flow. The flow was visualized using a suspension of seeding particles in water, and a laser sheet for illumination. With a finite time exposure, the particle motion was captured on a photograph as a pattern of streaks. The streak pattern was digitized and processed using various imaging operations, including contrast manipulation, noise cleaning, filtering, statistical differencing, and thresholding. Information concerning the velocity was extracted from the enhanced image by measuring the length and orientation of the individual streaks. The fluid velocities deduced from the randomly distributed particle streaks were interpolated to obtain velocities at uniform grid points. For the interpolation a simple convolution technique with an adaptive Gaussian window was used. The results are compared with a numerical prediction by a Navier-Stokes computation.

  17. Page: a program for gamma spectra analysis in PC microcomputers

    International Nuclear Information System (INIS)

    Goncalves, M.A.; Yamaura, M.; Costa, G.J.C.; Carvalho, E.I. de; Matsuda, H.T.; Araujo, B.F. de.

    1991-04-01

    PAGE is a software package, written in BASIC language, to perform gamma spectra analysis. It was developed to be used in a high-purity intrinsic germanium detector-multichannel analyser-PC microcomputer system. The analysis program of PAGE package accomplishes functions as follows: peak location; gamma nuclides identification; activity determination. Standard nuclides sources were used to calibrate the system. To perform the efficiency x energy calibration a logarithmic fit was applied. Analysis of nuclides with overlapping peaks is allowed by PAGE program. PAGE has additional auxiliary programs for: building and list of isotopic nuclear data libraries; data acquisition from multichannel analyser; spectrum display with automatic area and FWHM determinations. This software is to be applied in analytical process control where time response is a very important parameter. PAGE takes ca. 1.5 minutes to analyse a complex spectrum from a 4096 channels MCA. (author)

  18. Compressional Pc5 type pulsations in the morningside plasma sheet

    Directory of Open Access Journals (Sweden)

    A. Vaivads

    Full Text Available We study compressional pulsations in Pc5 frequency range observed in the dawn-side at distances of about 10 RE , close to the magnetic equator. We use data obtained during two events of conjunctions between Equator-S and Geotail: 1000–1700 UT on 9 March 1998, and 0200–0600 UT on 25 April 1998. In both events, pulsations are observed after substorm activity. The pulsations are antisymmetric with respect to the equatorial plane (even mode, and move eastward with phase velocity close to plasma velocity. The pulsations tend to be pressure balanced. We also discuss possible generation mechanisms of the pulsations.

    Key words. Magnetospheric physics (magnetospheric configuration and dynamics; MHD waves and instabilities; plasma sheet

  19. Compressional Pc5 type pulsations in the morningside plasma sheet

    Directory of Open Access Journals (Sweden)

    A. Vaivads

    2001-03-01

    Full Text Available We study compressional pulsations in Pc5 frequency range observed in the dawn-side at distances of about 10 RE , close to the magnetic equator. We use data obtained during two events of conjunctions between Equator-S and Geotail: 1000–1700 UT on 9 March 1998, and 0200–0600 UT on 25 April 1998. In both events, pulsations are observed after substorm activity. The pulsations are antisymmetric with respect to the equatorial plane (even mode, and move eastward with phase velocity close to plasma velocity. The pulsations tend to be pressure balanced. We also discuss possible generation mechanisms of the pulsations.Key words. Magnetospheric physics (magnetospheric configuration and dynamics; MHD waves and instabilities; plasma sheet

  20. Monte Carlo simulations on a 9-node PC cluster

    International Nuclear Information System (INIS)

    Gouriou, J.

    2001-01-01

    Monte Carlo simulation methods are frequently used in the fields of medical physics, dosimetry and metrology of ionising radiation. Nevertheless, the main drawback of this technique is to be computationally slow, because the statistical uncertainty of the result improves only as the square root of the computational time. We present a method, which allows to reduce by a factor 10 to 20 the used effective running time. In practice, the aim was to reduce the calculation time in the LNHB metrological applications from several weeks to a few days. This approach includes the use of a PC-cluster, under Linux operating system and PVM parallel library (version 3.4). The Monte Carlo codes EGS4, MCNP and PENELOPE have been implemented on this platform and for the two last ones adapted for running under the PVM environment. The maximum observed speedup is ranging from a factor 13 to 18 according to the codes and the problems to be simulated. (orig.)

  1. PC-AT to gamma camera interface Anugami-S

    International Nuclear Information System (INIS)

    Bhattacharya, Sadhana; Sonalkar, S.Y.; Kataria, S.K.

    2000-01-01

    The gamma camera interface ANUGAMI-S is an image acquisition system used in nuclear medicine centres and hospitals. The state of the art design of the interface provides quality improvement in addition to image acquisition, by applying on-line uniformity correction which is very essential for gamma camera applications in nuclear medicine. The improvement in the quality of the image has been achieved by image acquisition in positionally varying and sliding energy window. It supports all acquisition modes viz. static, dynamic and gated acquisition modes with and without uniformity correction. The user interface provides the acquisition in various user selectable parameters with image display and related acquisition parameter display. It is a universal system which provides a modern, cost effective and easily maintainable solution for interfacing any gamma camera to PC or upgradation of analog gamma camera. The paper describes the system details and gated acquisition achieved on the present system. (author)

  2. Detect-PC Software Version 3.0

    International Nuclear Information System (INIS)

    Arista Romeu, E. J.

    2011-01-01

    The 'Thyroid uptake system Detect-PC' developed and manufactured at CEADEN is object of follow-up by its manufacturer in order to fulfill the established national requirements to medical equipment. Taking into account observations from the users of the system, several modifications were implemented that resulted in a new software version, the 3.0.0. These modifications were mainly introduced to easy carrying out the energetic calibration of the system. In this new version all the working modes of the system were thoroughly tested and a Medic Physics was trained in the use of the application software. Acceptance tests were carried out in a thyroid uptake system installed in the Hermanos Ameijeiras Hospital, where this version of the software remained installed and in operation. (Author)

  3. Characterization of RNA interference in rat PC12 cells

    DEFF Research Database (Denmark)

    Thonberg, Håkan; Schéele, Camilla C; Dahlgren, Cecilia

    2004-01-01

    strand of the siRNA guides a multi-protein complex, RNA-induced silencing complex (RISC), to cleave target mRNA. Although the exact function and composition of RISC is still unclear, it has been shown to include several proteins of the Argonaute protein family. Here we report of a robust system...... of the rat Golgi-ER protein 95 kDa (GERp95), an Argonaute family protein, by siRNA methodology. After GERp95-ablation, sequential knockdown of NPY by siRNA was shown to be impaired. Thus, we report that the GERp95 protein is functionally required for RNAi targeting NPY in rat PC12 cells....

  4. Personal Computer-less (PC-less) Microcontroller Training Kit

    Science.gov (United States)

    Somantri, Y.; Wahyudin, D.; Fushilat, I.

    2018-02-01

    The need of microcontroller training kit is necessary for practical work of students of electrical engineering education. However, to use available training kit not only costly but also does not meet the need of laboratory requirements. An affordable and portable microcontroller kit could answer such problem. This paper explains the design and development of Personal Computer Less (PC-Less) Microcontroller Training Kit. It was developed based on Lattepanda processor and Arduino microcontroller as target. The training kit equipped with advanced input-output interfaces that adopted the concept of low cost and low power system. The preliminary usability testing proved this device can be used as a tool for microcontroller programming and industrial automation training. By adopting the concept of portability, the device could be operated in the rural area which electricity and computer infrastructure are limited. Furthermore, the training kit is suitable for student of electrical engineering student from university and vocational high school.

  5. Pc5 waves generated by substorm injection: a case study

    Directory of Open Access Journals (Sweden)

    N. A. Zolotukhina

    2008-07-01

    Full Text Available We analyzed the spectral-polarized characteristics of Pc5 ULF waves observed on 17 September 2000 after the 03:20:25 UT substorm onset with the satellites GOES 8 and 10 located east and west of the onset location. In the course of the event, the wave polarization changed from mixed (between toroidal and poloidal to poloidal, and then to mixed again. The hodogram of magnetic field oscillations rotated counterclockwise at GOES 8, and clockwise at GOES 10. It is suggested that the satellites detected the waves generated by the substorm injected clouds of the charged particles drifting in the magnetosphere in the opposite azimuthal directions: GOES 8 (located east of the substorm onset detected the wave generated by an electron cloud, and GOES 10 (west of the onset detected the wave generated by a positive ion cloud. This interpretation is confirmed by the energetic particles data recorded by LANL satellites.

  6. METHANE de-NOX FOR UTILITY PC BOILERS

    Energy Technology Data Exchange (ETDEWEB)

    Joseph Rabovitser

    2000-07-05

    The overall project objective is the development and validation of an innovative combustion system, based on a novel coal preheating concept prior to combustion, that can reduce NO{sub x} emissions to 0.15 lb/million Btu or less on utility pulverized coal (PC) boilers. This NO{sub x} reduction should be achieved without loss of boiler efficiency or operating stability, and at more than 25% lower levelized cost than state-of-the-art SCR technology. A further objective is to make this technology ready for full-scale commercial deployment by 2002-2003 in order to meet an anticipated market demand for NO{sub x} reduction technologies resulting from the EPA's NO{sub x} SIP call.

  7. Upgrading of analogue gamma cameras with PC based computer system

    International Nuclear Information System (INIS)

    Fidler, V.; Prepadnik, M.

    2002-01-01

    Full text: Dedicated nuclear medicine computers for acquisition and processing of images from analogue gamma cameras in developing countries are in many cases faulty and technologically obsolete. The aim of the upgrading project of International Atomic Energy Agency (IAEA) was to support the development of the PC based computer system which would cost 5.000 $ in total. Several research institutions from different countries (China, Cuba, India and Slovenia) were financially supported in this development. The basic demands for the system were: one acquisition card an ISA bus, image resolution up to 256x256, SVGA graphics, low count loss at high count rates, standard acquisition and clinical protocols incorporated in PIP (Portable Image Processing), on-line energy and uniformity correction, graphic printing and networking. The most functionally stable acquisition system tested on several international workshops and university clinics was the Slovenian one with a complete set of acquisition and clinical protocols, transfer of scintigraphic data from acquisition card to PC through PORT, count loss less than 1 % at count rate of 120 kc/s, improvement of integral uniformity index by a factor of 3-5 times, reporting, networking and archiving solutions for simple MS network or server oriented network systems (NT server, etc). More than 300 gamma cameras in 52 countries were digitized and put in the routine work. The project of upgrading the analogue gamma cameras yielded a high promotion of nuclear medicine in the developing countries by replacing the old computer systems, improving the technological knowledge of end users on workshops and training courses and lowering the maintenance cost of the departments. (author)

  8. Data of evolutionary structure change: 1ONAD-2D3PC [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1ONAD-2D3PC 1ONA 2D3P D C ADTIVAVELDTYPNTDIGDPSYPHIGIDIKSVRSKKTAK...WNMQNGKVGTAHIIYNSVDKRLSAVVSYPNADSATVSYDVDLDNVLPEWVRVGLSASTGLYKETNTILSWSFTSKLKT------NALHFMFNQFSKDQKDLILQGDAT...14> 1ONA D 1ONAD

  9. PrPC has nucleic acid chaperoning properties similar to the nucleocapsid protein of HIV-1.

    Science.gov (United States)

    Derrington, Edmund; Gabus, Caroline; Leblanc, Pascal; Chnaidermann, Jonas; Grave, Linda; Dormont, Dominique; Swietnicki, Wieslaw; Morillas, Manuel; Marck, Daniel; Nandi, Pradip; Darlix, Jean-Luc

    2002-01-01

    The function of the cellular prion protein (PrPC) remains obscure. Studies suggest that PrPC functions in several processes including signal transduction and Cu2+ metabolism. PrPC has also been established to bind nucleic acids. Therefore we investigated the properties of PrPC as a putative nucleic acid chaperone. Surprisingly, PrPC possesses all the nucleic acid chaperoning properties previously specific to retroviral nucleocapsid proteins. PrPC appears to be a molecular mimic of NCP7, the nucleocapsid protein of HIV-1. Thus PrPC, like NCP7, chaperones the annealing of tRNA(Lys) to the HIV-1 primer binding site, the initial step of retrovirus replication. PrPC also chaperones the two DNA strand transfers required for production of a complete proviral DNA with LTRs. Concerning the functions of NCP7 during budding, PrPC also mimices NCP7 by dimerizing the HIV-1 genomic RNA. These data are unprecedented because, although many cellular proteins have been identified as nucleic acid chaperones, none have the properties of retroviral nucleocapsid proteins.

  10. Relationship between PC index and magnetospheric field-aligned currents measured by Swarm satellites

    DEFF Research Database (Denmark)

    Troshichev, О.; Sormakov, D.; Behlke, R.

    2018-01-01

    Abstract The relationship between the magnetospheric field-aligned currents (FAC) monitored by the Swarm satellites and the magnetic activity PC index (which is a proxy of the solar wind energy incoming into the magnetosphere) is examined. It is shown that current intensities measured in the R1...... between the PC index and the intensity of field-aligned currents in the R1 dawn and dusk layers: increase of FAC intensity in the course of substorm development is accompanied by increasing the PC index values. Correlation between PC and FAC intensities in the R2 dawn and dusk layers is also observed...

  11. Effect of γ-radiation on glass transition temperature of Poly(Bisphenol A carbonate) (PC)

    International Nuclear Information System (INIS)

    Kalkar, A.K.; Kundagol, S.

    1988-01-01

    Thin films of pure Poly(Bisphenol A carbonate) (PC) were γ-irradiated at room temperature from Co 60 source for varied doses, for the systematic study of γ-radiation on glass transition temperature (Tsub(g)) of PC. It was found that Tsub(g) of PC decreases with increasing doses. Irradiation of γ-rays on PC results in evolution of CO, CO 2 and H 2 from carbonate linkage and methyl group and which results in lowering of average mol.wt. of bul k polymer. Hence, overall increase in free volume increases chain mobility and thus reduces the Tsub(g). (author)

  12. Accelerated 3D-OSEM image reconstruction using a Beowulf PC cluster for pinhole SPECT

    International Nuclear Information System (INIS)

    Zeniya, Tsutomu; Watabe, Hiroshi; Sohlberg, Antti; Iida, Hidehiro

    2007-01-01

    A conventional pinhole single-photon emission computed tomography (SPECT) with a single circular orbit has limitations associated with non-uniform spatial resolution or axial blurring. Recently, we demonstrated that three-dimensional (3D) images with uniform spatial resolution and no blurring can be obtained by complete data acquired using two-circular orbit, combined with the 3D ordered subsets expectation maximization (OSEM) reconstruction method. However, a long computation time is required to obtain the reconstruction image, because of the fact that 3D-OSEM is an iterative method and two-orbit acquisition doubles the size of the projection data. To reduce the long reconstruction time, we parallelized the two-orbit pinhole 3D-OSEM reconstruction process by using a Beowulf personal computer (PC) cluster. The Beowulf PC cluster consists of seven PCs connected to Gbit Ethernet switches. Message passing interface protocol was utilized for parallelizing the reconstruction process. The projection data in a subset are distributed to each PC. The partial image forward-and back-projected in each PC is transferred to all PCs. The current image estimate on each PC is updated after summing the partial images. The performance of parallelization on the PC cluster was evaluated using two independent projection data sets acquired by a pinhole SPECT system with two different circular orbits. Parallelization using the PC cluster improved the reconstruction time with increasing number of PCs. The reconstruction time of 54 min by the single PC was decreased to 10 min when six or seven PCs were used. The speed-up factor was 5.4. The reconstruction image by the PC cluster was virtually identical with that by the single PC. Parallelization of 3D-OSEM reconstruction for pinhole SPECT using the PC cluster can significantly reduce the computation time, whereas its implementation is simple and inexpensive. (author)

  13. A Comparison of the Apple Macintosh and IBM PC in Laboratory Applications.

    Science.gov (United States)

    Williams, Ron

    1986-01-01

    Compares Apple Macintosh and IBM PC microcomputers in terms of their usefulness in the laboratory. No attempt is made to equalize the two computer systems since they represent opposite ends of the computer spectrum. Indicates that the IBM PC is the most useful general-purpose personal computer for laboratory applications. (JN)

  14. IDGAM. A PC code and database to help nuclide identification in activation analysis

    International Nuclear Information System (INIS)

    Paviotti Corcuera, R.; Moraes Cunha, M. de; Jayanthi, K.A.

    1994-01-01

    The document describes a PC diskette containing a code and database which helps researchers to identify the nuclides in a radioactive sample. Data can be retrieved by gamma-ray energy, nuclide or element. The PC diskette is available, costfree, from the IAEA Nuclear Data Section, upon request. (author). 6 refs, 5 figs

  15. Isoform 1 of TPD52 (PC-1) promotes neuroendocrine transdifferentiation in prostate cancer cells

    KAUST Repository

    Moritz, Tom; Venz, Simone; Junker, Heike; Kreuz, Sarah; Walther, Reinhard; Zimmermann, Uwe

    2016-01-01

    The tumour protein D52 isoform 1 (PC-1), a member of the tumour protein D52 (TPD52) protein family, is androgen-regulated and prostate-specific expressed. Previous studies confirmed that PC-1 contributes to malignant progression in prostate cancer

  16. The UV (IUE) spectrum of the planetary nebula PC 11 (HD 149427)

    NARCIS (Netherlands)

    Parthasarathy, M; Garcia-Lario, P; Pottasch, [No Value; de Martino, D; Surendiranath, R

    The UV spectrum of PC 11 is found to show variations in the strength of the O III] 1666 Angstrom, N III] 1750 Angstrom and C III] 1909 Angstrom emission lines. The detection of continuum emission in the wavelength interval 2650 Angstrom to 3200 Angstrom indicates that the central star of PC 11 has

  17. INDXENDF: A PC code for indexing nuclear data files in ENDF-6 format

    International Nuclear Information System (INIS)

    Silva, O.O. de; Corcuera, R.P.; Ferreira, P.A.; Moraes Cunha, M. de.

    1992-01-01

    The PC code INDXENDF which creates visual or printed indexes of nuclear data files in ENDF-6 format, is available from the IAEA Nuclear Data Section on a PC diskette, free of charge upon request. The present document describes the features of this code. (author). 11 refs, 9 figs

  18. Synthesis and characterization of NiPcTSTNa(L) thin films

    Indian Academy of Sciences (India)

    Optical absorption studies of NiPcTSTNa(L) films were performed in the ... the HOMO–LUMO gap of NiPc as 2·41 eV and suggested that the orbitals next to the ..... magnitude of the electrical conductivities and feasibility of preparing these ...

  19. Physical and Mechanical Characteristics of Kevlar Fiber-Reinforced PC/ABS Composites

    Directory of Open Access Journals (Sweden)

    Kuljira Sujirote

    2012-01-01

    Full Text Available In this research, the composites between polycarbonate (PC and acrylonitrile-butadiene-styrene (ABS alloy and Kevlar fiber were prepared. The flexural and tensile properties of PC/ABS alloy and its composites were determined using a universal testing machine. The synergistic behavior of flexural modulus was observed for all regions of PC contents, while the synergism of flexural strength and tensile strength were found in some PC contents. It was found that the optimum weight ratio of PC:ABS was 60:40. In the Kevlar Fiber-reinforced PC/ABS composite system at PC:ABS of 60:40, both flexural modulus and strength were increased with matrix contents. Additionally, the flexural strength drastically increased with the matrix content and then reached the maximum value of 167 MPa at the matrix content of 33.4 wt%. The results from peel test, water contact measurement, and scanning electron microscopy (SEM reveal that the interfacial adhesion between the Kevlar fiber and the polymer matrix could be improved by increasing the PC content in the matrix.

  20. PROFIT-PC: a program for estimating maximum net revenue from multiproduct harvests in Appalachian hardwoods

    Science.gov (United States)

    Chris B. LeDoux; John E. Baumgras; R. Bryan Selbe

    1989-01-01

    PROFIT-PC is a menu driven, interactive PC (personal computer) program that estimates optimum product mix and maximum net harvesting revenue based on projected product yields and stump-to-mill timber harvesting costs. Required inputs include the number of trees/acre by species and 2 inches diameter at breast-height class, delivered product prices by species and product...

  1. Impact of ambient environment on the electronic structure of CuPc/Au sample

    Science.gov (United States)

    Sinha, Sumona; Mukherjee, M.

    2018-02-01

    The performances of organic devices are crucially connected with their stability in the ambient environment. The impact of 24 h. Ambient environment exposure to the electronic structures of about 12 nm thick CuPc thin film on clean Au substrate have been studied employing UV photoemission spectroscopy technique. X-ray photoemission spectroscopy (XPS) was used to find out the origin of the change of the electronic structures in the sample with the exposure. The XPS study suggests that the oxidation occurs at the CuPc thin film. Due to the adsorption of oxygen in the CuPc film from the ambient air, charge carriers are formed within the CuPc film. Moreover, the XPS results imply that the CuPc film is sufficiently thinner for diffusing oxygen molecules through it and gets physically absorbed on Au substrate during the ambient exposure. Consequently, the hole injection barrier height of pristine CuPc film, grown on Au substrate, is reduced by about 0.50 eV and work-function of the pristine CuPc sample is enhanced by around 0.25 eV in the exposure. The findings will help to understand the mechanism that governs the degradation of performance of CuPc based devices in ambient environment.

  2. USL/DBMS NASA/PC R and D project C programming standards

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Moreau, Dennis R.

    1984-01-01

    A set of programming standards intended to promote reliability, readability, and portability of C programs written for PC research and development projects is established. These standards must be adhered to except where reasons for deviation are clearly identified and approved by the PC team. Any approved deviation from these standards must also be clearly documented in the pertinent source code.

  3. The aPC treatment improves microcirculation in severe sepsis/septic shock syndrome

    NARCIS (Netherlands)

    Donati, Abele; Damiani, Elisa; Botticelli, Laura; Adrario, Erica; Lombrano, Maria Rita; Domizi, Roberta; Marini, Benedetto; van Teeffelen, Jurgen W. G. E.; Carletti, Paola; Girardis, Massimo; Pelaia, Paolo; Ince, Can

    2013-01-01

    The role of recombinant activated protein C (aPC) during sepsis is still controversial. It showed anti-inflammatory effect and improved the microvascular perfusion in experimental models of septic shock. The present study was aimed at testing the hypothesis that recombinant aPC therapy improves the

  4. Integrating a Single Tablet PC in Chemistry, Engineering, and Physics Courses

    Science.gov (United States)

    Rogers, James W.; Cox, James R.

    2008-01-01

    A tablet PC is a versatile computer that combines the computing power of a notebook with the pen functionality of a PDA (Cox and Rogers 2005b). The authors adopted tablet PC technology in order to improve the process and product of the lecture format in their chemistry, engineering, and physics courses. In this high-tech model, a single tablet PC…

  5. ERES--a PC software for nuclear data compilation in EXFOR format

    International Nuclear Information System (INIS)

    Li Shubing; Liang Qichang; Liu Tingjin

    1993-01-01

    The major functions and implementation of the software ERES (EXFOR Edit System) are introduced. The ERES is developed for nuclear data compilation in EXFOR (EXchange FORmat) format, running on IBM-PC/XT or IBM-PC/AT. EXFOR is the format for the exchange of experimental neutron data accepted by four neutron data centers in the world

  6. Effect of spermidine in PC12 cells on the cell apoptosis induced by enriched uranium

    International Nuclear Information System (INIS)

    Gu Guixiong; Zhu Shoupeng; Wang Liuyi; Yang Shuqin; Zhu Lingli

    2003-01-01

    This is a study on injurious effects of cellular spermidine to PC12 cells irradiated by enriched uranium. PC12 cells were cultured in DMEM/F12 medium with enriched uranium, and the exposure doses were calculated. The contents of free spermidine PC12 cells were examined with Dansyl-chloride reaction and thin-layer chromatography. Viability of the cells treated with enriched uranium reduced rapidly and DNA strand break increased significantly with increasing time of the irradiation. Autoradiographic tracks showed that the radionuclide located in the nucleus predominantly. The content of free spermidine in PC12 cells could markedly decrease as the irradiation time increased. The results suggested that PC12 cells exposured to enriched uranium were apoptotic and the free spermidine in cells might play some role in this process

  7. Phase Behavior, Thermal Stability and Rheological Properties of PPEK/PC Blends

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Phase behavior, thermal stability and rheological properties of the blends of poly(phthalazinone ether ketone) (PPEK)with bisphenol-A polycarbonate (PC) prepared by solution coprecipitation were studied using differential scanning calorimetry (DSC), Frourier-Transform IR spectroscopy (FT-IR), thermogravimetric analysis (TGA) and capillary rheometer. The DSC results indicated that PPEK/PC blends are almost immiscible in full compositions. FT-IR investigation showed that there were no apparent specific interactions between the constituent polymers. The blends keep excellent thermal stability and the addition of PC degrades the thermal stability of blends to some degree. The thermal degradation processes of the blends are much similar to that of PC. The studies on rheological properties of blends show that blending PPEK with PC is beneficial to reducing the melt viscosity and improving the appearance of PPEK.

  8. Reuse of the compact nuclear simulator software under PC with Linux

    International Nuclear Information System (INIS)

    Cha, K. H.; Park, J. C.; Kwon, K. C.; Lee, G. Y.

    2000-01-01

    This study was approached to reuse source programs for a nuclear simulator under PC with Open Source Software(OSS) and to extend its applicability. Source programs in the Compact Nuclear Simulator(CNS), which has been operated for institutional research and training in KAERI, were reused and implemented for Linux-PC environment with the aim of supporting the study. PC with 500 MHz processor and Linux 2.2.5-22 kernel were utilized for the reuse implementation and it was investigated for some applications, through the functional testing for its main functions as interfaced with compact control panels in the current CNS. Development and upgrade of small-scale simulators, establishment of process simulation for PC, and development of prototype predictive simulation, can effectively be enabled with the experience though the reuse implementation was limited to port only CNS programs for PC with Linux

  9. Model of Oxygen and Glucose Deprivation in PC12 Cells and Detection of HSP70 Protein

    Science.gov (United States)

    He, Jinting; Yang, Le; Shao, Yankun

    2018-01-01

    Objective: PC12 cell was used to set up a ischemia model by OGD and detected HSP70 protein. Methods: Use of PC12 cells induced by NGF stimulation into nerve cells, oxygen and glucose deprivation to build the nerve cells of oxygen and glucose deprivation model; using Western blot analysis of PC12 cells into neuron-like cells and oxygen-glucose deprivation model established. Results: The application of a final concentration of 50 ng / ml of NGF in DMEM complete mediumPC12 cells showed a typical neuronal morphology with the increase in cell culture time. NGF culture time showed a positive correlation, the establishment of oxygen and glucose deprivation (OGD) training environment, the OGD after nerve element appears different degrees of damage, OGD can effectively induce the expression of HSP70. Conclusion: PC12 cell transformed into cells by NGF; the cell model of OGD was established.

  10. Upgrading of analogue cameras using modern PC based computer

    International Nuclear Information System (INIS)

    Pardom, M.F.; Matos, L.

    2002-01-01

    Aim: The use of computers along with analogue cameras enables them to perform tasks involving time-activity parameters. The INFORMENU system converts a modern PC computer into a dedicated nuclear medicine computer system with a total cost affordable to emerging economic countries, and easily adaptable to all existing cameras. Materials and Methods: In collaboration with nuclear medicine physicians, an application including hardware and software was developed by a private firm. The system runs smoothly on Windows 98 and its operation is very easy. The main features are comparable to the brand commercial computer systems; such as image resolution until 1024 x 1024, low count loss at high count rate, uniformity correction, integrated graphical and text reporting, and user defined clinical protocols. Results: The system is used in more than 20 private and public institutions. The count loss is less than 1% in all the routine work, improvement of uniformity correction of 3-5 times, improved utility of the analogue cameras. Conclusion: The INFORMENU system improves the utility of analogue cameras permitting the inclusion of dynamic clinical protocols and quantifications, helping the development of the nuclear medicine practice. The operation and maintenance costs were lowered. The end users improve their knowledge of modern nuclear medicine

  11. KCl stimulation increases norepinephrine transporter function in PC12 cells.

    Science.gov (United States)

    Mandela, Prashant; Ordway, Gregory A

    2006-09-01

    The norepinephrine transporter (NET) plays a pivotal role in terminating noradrenergic signaling and conserving norepinephrine (NE) through the process of re-uptake. Recent evidence suggests a close association between NE release and regulation of NET function. The present study evaluated the relationship between release and uptake, and the cellular mechanisms that govern these processes. KCl stimulation of PC12 cells robustly increased [3H]NE uptake via the NET and simultaneously increased [3H]NE release. KCl-stimulated increases in uptake and release were dependent on Ca2+. Treatment of cells with phorbol-12-myristate-13-acetate (PMA) or okadaic acid decreased [3H]NE uptake but did not block KCl-stimulated increases in [3H]NE uptake. In contrast, PMA increased [3H]NE release and augmented KCl-stimulated release, while okadaic acid had no effects on release. Inhibition of Ca2+-activated signaling cascades with KN93 (a Ca2+ calmodulin-dependent kinase inhibitor), or ML7 and ML9 (myosin light chain kinase inhibitors), reduced [3H]NE uptake and blocked KCl-stimulated increases in uptake. In contrast, KN93, ML7 and ML9 had no effect on KCl-stimulated [3H]NE release. KCl-stimulated increases in [3H]NE uptake were independent of transporter trafficking to the plasma membrane. While increases in both NE release and uptake mediated by KCl stimulation require Ca2+, different intracellular mechanisms mediate these two events.

  12. CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY: INTERACTION WITH GLUCOCORTICOIDS IN PC12 CELLS

    Science.gov (United States)

    Slotkin, Theodore A.; Card, Jennifer; Seidler, Frederic J.

    2012-01-01

    Prenatal coexposures to glucocorticoids and organophosphate pesticides are widespread. Glucocorticoids are elevated by maternal stress and are commonly given in preterm labor; organophosphate exposures are virtually ubiquitous. We used PC12 cells undergoing neurodifferentiation in order to assess whether dexamethasone enhances the developmental neurotoxicity of chlorpyrifos, focusing on concentrations relevant to human exposures. By themselves, each agent reduced the number of cells and the combined exposure elicited a correspondingly greater effect than with either agent alone. There was no general cytotoxicity, as cell growth was actually enhanced, and again, the combined treatment evoked greater cellular hypertrophy than with the individual compounds. The effects on neurodifferentiation were more complex. Chlorpyrifos alone had a promotional effect on neuri to genesis whereas dexamethasone impaired it; combined treatment showed an overall impairment greater than that seen with dexamethasone alone. The effect of chlorpyrifos on differentiation into specific neurotransmitter phenotypes was shifted by dexamethasone. Either agent alone promoted differentiation into the dopaminergic phenotype at the expense of the cholinergic phenotype. However, in dexamethasone-primed cells, chlorpyrifos actually enhanced cholinergic neurodifferentiation instead of suppressing this phenotype. Our results indicate that developmental exposure to glucocorticoids, either in the context of stress or the therapy of preterm labor, could enhance the developmental neurotoxicity of organophosphates and potentially of other neurotoxicants, as well as producing neurobehavioral outcomes distinct from those seen with either individual agent. PMID:22796634

  13. Interaction With PC Tablets And Possible Emotional Responses

    Directory of Open Access Journals (Sweden)

    Emy Agren

    2015-08-01

    Full Text Available The remarkable developments in mobile-based technologies have brought prominent impacts on human life style. Today life is running on mobile electronic devices smart phones tablets gaming devices and video-players. Generally the users acquaint with the features and properties of products after emotionally and physically interacting with the devices. The interaction in return influencing our moods depending on the feelings the technology creates. The focus of this study lays on the uses of tablets or also called PC tablets and its effects on its users emotional responses. To discover possible emotional responses with the tablets the data in this work were collected through a survey questionnaire from participants belongs to various backgrounds age groups and genders. The model of emotions was adopted in order to classify the emotional responses.The study has found that during or after the interaction with the tablets the users may get positive or negative emotional responses of a different kind. The users mood can also be affected by awakening such emotional feelings as happiness sadness frustration etc.

  14. Measurement of radiation dose with a PC-based instrument

    International Nuclear Information System (INIS)

    Jangland, L.; Neubeck, R.

    1994-01-01

    The purpose of this study was to investigate in what way the introduction of Digital Subtraction Angiography has influenced absorbed doses to the patient and personnel. Calculation of the energy imparted to the patient, ε, was based on measurements of the dose-area product, tube potential and tube current which were registered with a PC-based instrument. The absorbed doses to the personnel were measured with TLD. The measurements on the personnel were made only at the digital system. The results indicate large variations in ε between different types of angiographic examinations of the same type. The total ε were similar on both systems, although the relative contribution from image acquisition and fluoroscopy were different. At the conventional system fluoroscopy and image acquisition contributed almost equally to the total ε. At the digital system 25% of the total ε was due to fluoroscopy and 75% to image acquisition. The differences were due to longer fluoroscopic times on the conventional system, mainly due to lack of image memory and road mapping, and lower ε/image, due to lower dose settings to the film changer compared to the image intensifier on the digital system. 11 refs., 8 figs., 9 tabs

  15. Indexes of large genome collections on a PC.

    Directory of Open Access Journals (Sweden)

    Agnieszka Danek

    Full Text Available The availability of thousands of individual genomes of one species should boost rapid progress in personalized medicine or understanding of the interaction between genotype and phenotype, to name a few applications. A key operation useful in such analyses is aligning sequencing reads against a collection of genomes, which is costly with the use of existing algorithms due to their large memory requirements. We present MuGI, Multiple Genome Index, which reports all occurrences of a given pattern, in exact and approximate matching model, against a collection of thousand(s genomes. Its unique feature is the small index size, which is customisable. It fits in a standard computer with 16-32 GB, or even 8 GB, of RAM, for the 1000GP collection of 1092 diploid human genomes. The solution is also fast. For example, the exact matching queries (of average length 150 bp are handled in average time of 39 µs and with up to 3 mismatches in 373 µs on the test PC with the index size of 13.4 GB. For a smaller index, occupying 7.4 GB in memory, the respective times grow to 76 µs and 917 µs. Software is available at http://sun.aei.polsl.pl/mugi under a free license. Data S1 is available at PLOS One online.

  16. PC_Eyewitness: evaluating the New Jersey method.

    Science.gov (United States)

    MacLin, Otto H; Phelan, Colin M

    2007-05-01

    One important variable in eyewitness identification research is lineup administration procedure. Lineups administered sequentially (one at a time) have been shown to reduce the number of false identifications in comparison with those administered simultaneously (all at once). As a result, some policymakers have adopted sequential administration. However, they have made slight changes to the method used in psychology laboratories. Eyewitnesses in the field are allowed to take multiple passes through a lineup, whereas participants in the laboratory are allowed only one pass. PC_Eyewitness (PCE) is a computerized system used to construct and administer simultaneous or sequential lineups in both the laboratory and the field. It is currently being used in laboratories investigating eyewitness identification in the United States, Canada, and abroad. A modified version of PCE is also being developed for a local police department. We developed a new module for PCE, the New Jersey module, to examine the effects of a second pass. We found that the sequential advantage was eliminated when the participants were allowed to view the lineup a second time. The New Jersey module, and steps we are taking to improve on the module, are presented here and are being made available to the research and law enforcement communities.

  17. STREAK CAMERA MEASUREMENTS OF THE APS PC GUN DRIVE LASER

    Energy Technology Data Exchange (ETDEWEB)

    Dooling, J. C.; Lumpkin, A. H.

    2017-06-25

    We report recent pulse-duration measurements of the APS PC Gun drive laser at both second harmonic and fourth harmonic wavelengths. The drive laser is a Nd:Glass-based chirped pulsed amplifier (CPA) operating at an IR wavelength of 1053 nm, twice frequency-doubled to obtain UV output for the gun. A Hamamatsu C5680 streak camera and an M5675 synchroscan unit are used for these measurements; the synchroscan unit is tuned to 119 MHz, the 24th subharmonic of the linac s-band operating frequency. Calibration is accomplished both electronically and optically. Electronic calibration utilizes a programmable delay line in the 119 MHz rf path. The optical delay uses an etalon with known spacing between reflecting surfaces and is coated for the visible, SH wavelength. IR pulse duration is monitored with an autocorrelator. Fitting the streak camera image projected profiles with Gaussians, UV rms pulse durations are found to vary from 2.1 ps to 3.5 ps as the IR varies from 2.2 ps to 5.2 ps.

  18. Intracranial artery velocity measurement using 4D PC MRI at 3 T: comparison with transcranial ultrasound techniques and 2D PC MRI

    International Nuclear Information System (INIS)

    Meckel, Stephan; Leitner, Lorenz; Schubert, Tilman; Bonati, Leo H.; Lyrer, Philippe; Santini, Francesco; Stalder, Aurelien F.; Markl, Michael; Wetzel, Stephan G.

    2013-01-01

    4D phase contrast MR imaging (4D PC MRI) has been introduced for spatiotemporal evaluation of intracranial hemodynamics in various cerebrovascular diseases. However, it still lacks validation with standards of reference. Our goal was to compare blood flow quantification derived from 4D PC MRI with transcranial ultrasound and 2D PC MRI. Velocity measurements within large intracranial arteries [internal carotid artery (ICA), basilar artery (BA), and middle cerebral artery (MCA)] were obtained in 20 young healthy volunteers with 4D and 2D PC MRI, transcranial Doppler sonography (TCD), and transcranial color-coded duplex sonography (TCCD). Maximum velocities at peak systole (PSV) and end diastole (EDV) were compared using regression analysis and Bland-Altman plots. Correlation of 4D PC MRI measured velocities was higher in comparison with TCD (r = 0.49-0.66) than with TCCD (0.35-0.44) and 2D PC MRI (0.52-0.60). In mid-BA and ICA C7 segment, a significant correlation was found with TCD (0.68-0.81 and 0.65-0.71, respectively). No significant correlation was found in carotid siphon. On average over all volunteers, PSVs and EDVs in MCA were minimally underestimated compared with TCD/TCCD. Minimal overestimation of velocities was found compared to TCD in mid-BA and ICA C7 segment. 4D PC MRI appears as valid alternative for intracranial velocity measurement consistent with previous reference standards, foremost with TCD. Spatiotemporal averaging effects might contribute to vessel size-dependent mild underestimation of velocities in smaller (MCA), and overestimation in larger-sized (BA and ICA) arteries, respectively. Complete spatiotemporal flow analysis may be advantageous in anatomically complex regions (e.g. carotid siphon) relative to restrictions of ultrasound techniques. (orig.)

  19. Limb-bud and Heart Overexpression Inhibits the Proliferation and Migration of PC3M Cells.

    Science.gov (United States)

    Liu, Qicai; Li, Ermao; Huang, Long; Cheng, Minsheng; Li, Li

    2018-01-01

    Background: The limb-bud and heart gene ( LBH ) was discovered in the early 21st century and is specifically expressed in the mouse embryonic limb and heart development. Increasing evidences have indicated that LBH not only plays an important role in embryo development, it is also closely correlated with the occurance and progression of many tumors. However, its function in prostate cancer (PCa) is still not well understood. Here, we explored the effects of LBH on the proliferation and migration of the PCa cell line PC3M. Methods: LBH expression in tissues and cell lines of PCa was detected by immunohistochemistry and Western blotting. Lentivirus was used to transduct the LBH gene into the PC3M cells. Stable LBH-overexpressing PC3M-LBH cells and PC3M-NC control cells were obtained via puromycin screening. Cell proliferation was examined using the 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Cell cycle distribution and apoptosis rate were investigated using flow cytometry. Cell migration was studied using the Transwell assay. Results: LBH expression level was down-regulated in 3 different PCa cell lines, especially in PC3M cells, compared with the normal prostate epithelial cells(RWPE-1). Cell lines of LBH-upregulated PC3M-LBH and PC3M-NC control were successfully constructed. Significantly increased LBH expression level and decreased cyclin D1 and cyclin E2 expression level was found in PC3M-LBH cells as compared to the PC3M-NC cells. The overexpression of LBH significantly inhibited PC3M cell proliferation in vitro and tumor growth in nude mice. LBH overexpression in PC3M cell, also induced cell cycle G0/G1 phase arrest and decreased the migration of PC3M cells. Conclusions : Our results reveal that LBH expression is down-regulated in the tissue and cell lines of PCa. LBH overexpression inhibits PC3M cell proliferation and tumor growth by inducing cell cycle arrest through down-regulating cyclin D1and cyclin E2 expression. LBH might

  20. Reduction of seismic response long-span PC cable-stayed bridge by passive dampers; Damper ni yoru saidai PC shachokyo no jishinji oto no teigen

    Energy Technology Data Exchange (ETDEWEB)

    Takeda, T.; Yamanobe, S.; Niihara, Y. [Kajima Corp., Tokyo (Japan)

    1994-10-31

    It is important in designing a PC cable-stayed bridge to properly estimate the seismic response of the bridge for reduction of the response. In this paper, an improvement of the seismic resistance of PC cable-stayed bridges when dampers are installed between the deck and piers and lateral vibration of the deck is restricted is investigated using a time history response model. PC cable-stayed bridges with a span length of 400 m, particularly two types of bridges of harp and semi-harp are investigated and the following is found by analyzing the case where there are installed hysteresis type dampers (with 1 cm yield displacement and secondary rigidity assumed to be 1/10 times that of initial rigidity, the initial rigidity being parametrically changed.) or viscous type dampers (a damping factor is changed.) The result shows that the dampers can reduce the seismic response of a PC cable-stayed bridge and that a semi-harp configuration of stay cables where stay cable members are substantially vertically arranged is more effective than a harp configuration for the seismic performance of PC cable-stayed bridges. The damper partly bear inertial force of the bridge upon earthquake whereby tension of the stay cable members is reduced and bending moment of the deck is reduced. There is existing an optimum characteristic value of the damper concerning the bending moment of the piers. 5 refs., 7 figs., 2 tabs.

  1. PC-based control of a high-voltage injector

    International Nuclear Information System (INIS)

    Constantin, F.

    1998-01-01

    The stability of high voltage injectors is one of the major problems in any accelerator system. Most of the troubles encountered in the normal operation of an accelerator are connected with the ion source and associated high voltage platforms, regardless of the source or high voltage generator type. The quality of the ion beam injected in the accelerator strongly depends on the power supplies used in the injector and on the ability to control the non-electrical parameters (gas-flow, temperature, etc.). A wide used method in controlling is based on optical links between high-voltage platform and computer, the adjustments being more or less automated. Although the method mentioned above can be still useful in injector control, a different approach is presented in this work, i.e., the computer itself is placed inside the high-voltage terminal. Only one optical link is still necessary to connect this computer with an user-friendly host at ground potential. Requirements: - varying and monitoring the filament current; - gas flow control in the ion source; - reading the vacuum values; - current and voltage control for the anodic, magnet, extraction, suppression and lens' sources. Even in the high voltage terminal there are compartments with different voltages regardless the floating ground. In our injector the extraction voltage is applied on the top of the ion source including the filament and the anodic voltage. The extraction voltage is of maximum 30 kV. In this situation a second optical link is required to transfer the control for the anodic and magnet source power supply assuming the dedicated computer on the floating ground. One PC is placed inside the high voltage terminal and one PC outside the injector. The optical link (more precisely two optical wires) connects the serial ports. The inside computer is equipped with two multipurpose ADC/DAC and digital I/O card. They permit to read or output DC levels ranging between 0 to 10 volts or TTL signals. The filament

  2. Prognostic significance of the PC10 index for patients with stage II and III oesophageal cancer treated with radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Sugahara, Shinji; Irie, Toshiyuki; Nozawa, Kumiko; Nakajima, Kotaro [Hitachi General Hospital, Ibaraki (Japan). Dept. of Radiology; Ohara, Kiyoshi; Itai, Yuji [Tsukuba Univ., Ibaraki (Japan). Dept. of Radiology; Takahashi, Atsushi [Hitachi General Hospital, Ibaraki (Japan). Dept. of Pathology; Watanabe, Teruo [Tsukuba Univ., Ibaraki (Japan). Dept. of Pathology; Tanaka, Naomi [Tsukuba Univ., Ibaraki (Japan). Dept. of Internal Medicine

    1999-07-01

    The monoclonal antibody PC10 is used for immunohistochemical staining of the proliferating cell nuclear antigen (PCNA). The percentage of PC10-positive cancer cells is defined as the PC10 index. We evaluated the relationship between the PC10 index in pretreatment endoscopic biopsies and the prognoses of 47 patients with Stage II-III oesophageal squamous cell carcinoma treated with radiotherapy. The patients with a PC10 index >40% had significantly poorer prognoses than the other patients (p=0.0007). Proportional hazards model analysis indicated that only the PC10 index was a prognostic factor (p=0.0009). The patient group of complete responders showed significantly lower PC10 indices compared to patients with a partial response or no change (p=0.049). The PC10 index can be a good predictive indicator of the prognosis in patients with Stage II-III oesophageal cancer treated with radiotherapy. (orig.)

  3. Equipment Qualification and Environment Establishment for COTS Dedication of Safety Grade PC

    International Nuclear Information System (INIS)

    Ahn, Kwang Chul; Bin, Chang Sun; Kwon, Yoon Kwang; Kang, Shin Woo; Koh, Sung Won; Shon, Eui Chan; Jang, Hyun Doo; Song, Il Sup; Lee, Hyun Noh

    2010-08-01

    Safety grade PCs are required for protection systems of SKN 3 and 4 nuclear power plant and subsequent plants. Commercial grade item (CGI) dedication should be carried out to utilize a commercial PC as a safety grade PC of nuclear power plants. This project is aimed to perform the equipment qualification of the commercial PC, and review and improve the quality system of the PC supplier. As a result of the EQ for the CGI dedication, selected military PCs have passed the environment test, the seismic test, and the EMI test required for the digital controllers of nuclear plants. In addition, a walk-through of the quality system of the PC supplier, ISO 9001, was carried out and the quality system was improved. History data for the PC was gathered. As the analysis of the history data showed that operating experience time of the PC is longer than the plant life time, the history data could be used as an evidence of acceptance. After dedicated according to the CGI dedication process, military rugged PCs could be used for safety grade PCs

  4. [Inhibition effects of black rice pericarp extracts on cell proliferation of PC-3 cells].

    Science.gov (United States)

    Jiang, Weiwei; Yu, Xudong; Ren, Guofeng

    2013-05-01

    To observe the inhibitive effects of black rice pericarp extracts on cell proliferation of human prostate cancer cell PC-3 and to explore its effecting mechanism. The black rice pericarp extract was used to treat the PC-3 cells. The inhibitory effect of black rice pericarp extract on cells proliferation of PC-3 was tested by MTT method. Cell apoptosis rates and cell cycle were measured by flow cytometric assay (FCM). Western blot was used to study the protein expression levels of p38, p-p38, JNK, p-JNK. A dose-dependent and time-dependent proliferation inhibition of black rice pericarp extract was demonstrated in PC-3. The most prominent experiment condition was inhibitory concentration with 300microg/ml and treated for 72 h. The experiment result of flow cytometry analysis demonstrates that the apoptosis rate of PC-3 cells increased along with the increasing of black rice pericarp extract concentration, and a G1-S cell cycle arrest was induced in a dose-dependent manner. After PC-3 cell was treated with black rice pericarp extract for 72 h, the expressions of p-p38, p-JNK protein increased. Black rice pericarp extract could inhibit proliferation, change the cell cycle distributions and induce apoptosis in human prostatic cancer cell PC-3. Its inhibitory effect may be through promoting activation of the JNK, p38 signaling pathway. These results suggest that black rice pericarp extract maybe has an inhibitory effect on prostatic cancer.

  5. Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites

    Science.gov (United States)

    Mortusewicz, Oliver; Roth, Wera; Li, Na; Cardoso, M. Cristina; Meisterernst, Michael; Leonhardt, Heinrich

    2008-01-01

    The multifunctional nuclear protein positive cofactor 4 (PC4) is involved in various cellular processes including transcription, replication, and chromatin organization. Recently, PC4 has been identified as a suppressor of oxidative mutagenesis in Escherichia coli and Saccharomyces cerevisiae. To investigate a potential role of PC4 in mammalian DNA repair, we used a combination of live cell microscopy, microirradiation, and fluorescence recovery after photobleaching analysis. We found a clear accumulation of endogenous PC4 at DNA damage sites introduced by either chemical agents or laser microirradiation. Using fluorescent fusion proteins and specific mutants, we demonstrated that the rapid recruitment of PC4 to laser-induced DNA damage sites is independent of poly(ADP-ribosyl)ation and γH2AX but depends on its single strand binding capacity. Furthermore, PC4 showed a high turnover at DNA damages sites compared with the repair factors replication protein A and proliferating cell nuclear antigen. We propose that PC4 plays a role in the early response to DNA damage by recognizing single-stranded DNA and may thus initiate or facilitate the subsequent steps of DNA repair. PMID:19047459

  6. APC-PC Combined Scheme in Gilbert Two State Model: Proposal and Study

    Science.gov (United States)

    Bulo, Yaka; Saring, Yang; Bhunia, Chandan Tilak

    2017-04-01

    In an automatic repeat request (ARQ) scheme, a packet is retransmitted if it gets corrupted due to transmission errors caused by the channel. However, an erroneous packet may contain both erroneous bits and correct bits and hence it may still contain useful information. The receiver may be able to combine this information from multiple erroneous copies to recover the correct packet. Packet combining (PC) is a simple and elegant scheme of error correction in transmitted packet, in which two received copies are XORed to obtain the bit location of erroneous bits. Thereafter, the packet is corrected by bit inversion of bit located as erroneous. Aggressive packet combining (APC) is a logic extension of PC primarily designed for wireless communication with objective of correcting error with low latency. PC offers higher throughput than APC, but PC does not correct double bit errors if occur in same bit location of erroneous copies of the packet. A hybrid technique is proposed to utilize the advantages of both APC and PC while attempting to remove the limitation of both. In the proposed technique, applications of APC-PC on Gilbert two state model has been studied. The simulation results show that the proposed technique offers better throughput than the conventional APC and lesser packet error rate than PC scheme.

  7. Web based 3-D medical image visualization on the PC.

    Science.gov (United States)

    Kim, N; Lee, D H; Kim, J H; Kim, Y; Cho, H J

    1998-01-01

    With the recent advance of Web and its associated technologies, information sharing on distribute computing environments has gained a great amount of attention from many researchers in many application areas, such as medicine, engineering, and business. One basic requirement of distributed medical consultation systems is that geographically dispersed, disparate participants are allowed to exchange information readily with each other. Such software also needs to be supported on a broad range of computer platforms to increase the softwares accessibility. In this paper, the development of world-wide-web based medical consultation system for radiology imaging is addressed to provide platform independence and greater accessibility. The system supports sharing of 3-dimensional objects. We use VRML (Virtual Reality Modeling Language), which is the defacto standard in 3-D modeling on the Web. 3-D objects are reconstructed from CT or MRI volume data using a VRML format, which can be viewed and manipulated easily in Web-browsers with a VRML plug-in. A Marching cubes method is used in the transformation of scanned volume data sets to polygonal surfaces of VRML. A decimation algorithm is adopted to reduce the number of meshes in the resulting VRML file. 3-D volume data are often very large in size, hence loading the data on PC level computers requires a significant reduction of the size of the data, while minimizing the loss of the original shape information. This is also important to decrease network delays. A prototype system has been implemented (http://cybernet5.snu.ac.kr/-cyber/mrivrml .html), and several sessions of experiments are carried out.

  8. Global Pc 5 event of November 14--15, 1979

    International Nuclear Information System (INIS)

    Higbie, P.R.; Baker, D.N.; Zwickl, R.D.; Belian, R.D.; Asbridge, J.R.; Fennell, J.F.; Wilken, B.; Arthur, C.W.

    1982-01-01

    Large-amplitude Pc 5 waves with 7--8 min quasi-periodic variations were observed almost continuously for the 48 hours of November 14--15, 1979, by several spacecraft in or near geostationary orbit on the dayside portions of their orbits. The waves were observed as large modulations in both the electron and ion fluxes over a wide range of energies (approx.1 to 500 keV) by the spacecraft 1976--059, 1977-007, 1979-053, P78-2, and GEOS 2 and as magnetic field peak-to-peak modulations of 15--25 γ by the P78-2 and GOES 2 and 3 magnetometers. The remarkably long persistence of these waves contrasts substantially with observations of typical flux modulation events which usually last less than 1 hour and which typically show little modulation of the > or =150 keV proton fluxes. Data taken concurrently by the ISEE spacecraft in the solar wind and outer magnetosphere indicate that the solar wind also had unusually properties. ISEE 3 measurements indicate that the solar wind velocity (approx.350 km/s) and density (approx.2 cm -3 ) were simultaneously very low for this period. The alpha-to-proton ratio for the solar wind plasma attained an extremely low value (<1%) early in the event. These solar wind properties imply such a much reduced dynamic pressure on the magnetosphere during this period. Consequently, the ISEE 1 and 2 spacecraft passed through the magnetopause at the uncommonly large radial distance of 18 R/sub E/ at approx.0830 local time where the typical magnetopause geocentric distance is 12 R/sub E/. The exceptional solar wind and outer magnetospheric conditions may have determined the unusual properties of the ULF event observed near geostationary orbit. Some candidate mechanisms for producing these oscillations are presented, but no definitive explanation for this event can be given at present

  9. Development of austenitic stainless steel PC wire and strand

    International Nuclear Information System (INIS)

    Tsubono, Hideyoshi; Kawabata, Yoshinori; Yamaoka, Yukio

    1986-01-01

    The effects of aging and stress-aging (called hot stretching) at the temperatures from 120 deg C to 700 deg C on the mechanical properties, relaxation values, Charpy impact values and SCC behavior of hard drawn SUS 304, SUS 316 stainless steel wires have been studied. The main results obtained are as follows: (1) Yield and tensile strength of the wires increased by aging at 230 deg C and 530 deg C as well as by hot stretching. The strengthening after 230 deg C treatment may be due to the strain aging by C and the increase of strength after 530 deg C treatment results from precipitation of Cr 23 C 6 on dislocations. (2) Stress relaxation values up to 250 deg C are low due to precipitation of Cr 23 C 6 . Almost no difference can be observed between aging and hot stretching. (3) Impact value at -196 deg C of SUS 304 stainless steel wire which was measured with 1 mm V-notched specimen was found to be about the same as that of 9 % Ni steel. (4) It is considered that in comparison with high carbon PC wire SUS 304 stainless steel showing high tensile strength is insensitive to SCC in NH 4 SCN and NH 4 NO 3 solutions. (5) In practice, tension member of the austenitic stainless steel wire and strand which were produced by aging at 500 deg C may be useful in special industrial field, for example, (a) SUS 304, in cryogenic field use (b) SUS 316, in intensive magnetic field use as a nonmagnetic material. (author)

  10. PC/FRAM, Version 3.2 User Manual

    International Nuclear Information System (INIS)

    Kelley, T.A.; Sampson, T.E.

    1999-01-01

    This manual describes the use of version 3.2 of the PC/FRAM plutonium isotopic analysis software developed in the Safeguards Science and Technology Group, NE-5, Nonproliferation and International Security Division Los Alamos National Laboratory. The software analyzes the gamma ray spectrum from plutonium-bearing items and determines the isotopic distribution of the plutonium 241Am content and concentration of other isotopes in the item. The software can also determine the isotopic distribution of uranium isotopes in items containing only uranium. The body of this manual descenies the generic version of the code. Special facility-specific enhancements, if they apply, will be described in the appendices. The information in this manual applies equally well to version 3.3, which has been licensed to ORTEC. The software can analyze data that is stored in a file on disk. It understands several storage formats including Canberra's S1OO format, ORTEC'S 'chn' and 'SPC' formats, and several ASCII text formats. The software can also control data acquisition using an MCA and then store the results in a file on disk for later analysis or analyze the spectrum directly after the acquisition. The software currently only supports the control of ORTEC MCB'S. Support for Canbema's Genie-2000 Spectroscopy Systems will be added in the future. Support for reading and writing CAM files will also be forthcoming. A versatile parameter fde database structure governs all facets of the data analysis. User editing of the parameter sets allows great flexibility in handling data with different isotopic distributions, interfering isotopes, and different acquisition parameters such as energy calibration, and detector type. This manual is intended for the system supervisor or the local user who is to be the resident expert. Excerpts from this manual may also be appropriate for the system operator who will routinely use the instrument

  11. Manganese oxidation state mediates toxicity in PC12 cells

    International Nuclear Information System (INIS)

    Reaney, S.H.; Smith, D.R.

    2005-01-01

    The role of the manganese (Mn) oxidation state on cellular Mn uptake and toxicity is not well understood. Therefore, undifferentiated PC12 cells were exposed to 0-200 μM Mn(II)-chloride or Mn(III)-pyrophosphate for 24 h, after which cellular manganese levels were measured along with measures of cell viability, function, and cytotoxicity (trypan blue exclusion, medium lactate dehydrogenase (LDH), 8-isoprostanes, cellular ATP, dopamine, serotonin, H-ferritin, transferrin receptor (TfR), Mn-superoxide dismutase (MnSOD), and copper-zinc superoxide dismutase (CuZnSOD) protein levels). Exposures to Mn(III) >10 μM produced 2- to 5-fold higher cellular manganese levels than equimolar exposures to Mn(II). Cell viability and ATP levels both decreased at the highest Mn(II) and Mn(III) exposures (150-200 μM), while Mn(III) exposures produced increases in LDH activity at lower exposures (≥50 μM) than did Mn(II) (200 μM only). Mn(II) reduced cellular dopamine levels more than Mn(III), especially at the highest exposures (50% reduced at 200 μM Mn(II)). In contrast, Mn(III) produced a >70% reduction in cellular serotonin at all exposures compared to Mn(II). Different cellular responses to Mn(II) exposures compared to Mn(III) were also observed for H-ferritin, TfR, and MnSOD protein levels. Notably, these differential effects of Mn(II) versus Mn(III) exposures on cellular toxicity could not simply be accounted for by the different cellular levels of manganese. These results suggest that the oxidation state of manganese exposures plays an important role in mediating manganese cytotoxicity

  12. Isoform 1 of TPD52 (PC-1) promotes neuroendocrine transdifferentiation in prostate cancer cells

    KAUST Repository

    Moritz, Tom

    2016-02-05

    The tumour protein D52 isoform 1 (PC-1), a member of the tumour protein D52 (TPD52) protein family, is androgen-regulated and prostate-specific expressed. Previous studies confirmed that PC-1 contributes to malignant progression in prostate cancer with an important role in castration-resistant stage. In the present work, we identified its impact in mechanisms leading to neuroendocrine (NE) transdifferentiation. We established for long-term PC-1 overexpression an inducible expression system derived from the prostate carcinoma cell line LNCaP. We observed that PC-1 overexpression itself initiates characteristics of neuroendocrine cells, but the effect was much more pronounced in the presence of the cytokine interleukin-6 (IL-6). Moreover, to our knowledge, this is the first report that treatment with IL-6 leads to a significant upregulation of PC-1 in LNCaP cells. Other TPD52 isoforms were not affected. Proceeding from this result, we conclude that PC-1 overexpression enhances the IL-6-mediated differentiation of LNCaP cells into a NE-like phenotype, noticeable by morphological changes and increased expression of typical NE markers, like chromogranin A, synaptophysin or beta-3 tubulin. Immunofluorescent staining of IL-6-treated PC-1-overexpressing LNCaP cells indicates a considerable PC-1 accumulation at the end of the long-branched neuron-like cell processes, which are typically formed by NE cells. Additionally, the experimentally initiated NE transdifferentiation correlates with the androgen receptor status, which was upregulated additively. In summary, our data provide evidence for an involvement of PC-1 in NE transdifferentiation, frequently associated with castration resistance, which is a major therapeutic challenge in the treatment of advanced prostate cancer.

  13. [Synthesis of a supermolecular nanoparticle γ-hy-PC/Ada-Dox and its antitumor activity].

    Science.gov (United States)

    Li, Yong-bin; Wang, Kai; Hu, Tian-nan; Wang, Qi-wen; Hu, Qi-da; Zhou, Jun; Hu, Xiu-rong; Tang, Gu-ping

    2012-11-01

    To synthesize a (2-Hydroxypropyl)-γ-cyclodextrin-polyethylenimine/adamantane-conjugated doxorubicin (γ-hy-PC/Ada-Dox) based supramolecular nanoparticle with host-guest interaction and to identify its physicochemical characterizations and antitumor effect. A novel non-viral gene delivery vector γ-hy-PC/Ada-Dox was synthesized based on host-guest interaction. 1H-NMR, NOESY, UV-Vis, XRD and TGA were used to confirm the structure of the vector. The DNA condensing ability of complexes was investigated by particle size, zeta potential and gel retardation assay. Cytotoxicity of complexes was determined by MTT assay in BEL-7402 and SMMC-7721 cells. Cell wound healing assay was performed in HEK293 and BEL-7404 cells. The transfection efficiency was investigated in HEK293 cells. H/E staining and cell uptake assay was performed in BEL-7402 cells. The structure of γ-hy-PC/Ada-Dox was characterized by 1H-NMR, NOESY, UV-Vis, XRD, TGA. The drug loading was 0.5% and 5.5%. Gel retardation assay showed that γ-hy-PC was able to completely condense DNA at N/P ratio of 2; 0.5% and 5.5% γ-hy-PC/Ada-Dox was able to completely condense DNA at N/P ratio of 3 and 4,respectively. The cytotoxicity of polymers was lower than that of PEI25KDa. The transfection efficiency of γ-hy-PC was higher than that of γ-hy-PC/Ada-Dox at N/P ratio of 30 in HEK293 cells; and the transfection efficiency was decreasing when Ada-Dox loading was increasing. Cell uptake assay showed that γ-hy-PC/Ada-Dox was able to carry drug and FAM-siRNA into cells. The novel vector γ-hy-PC/Ada-Dox has been developed successfully, which has certain transfection efficiency and antitumor activity.

  14. Antagonism in the extraction of uranium(VI) by the binary mixture of PC88A and benzimidazole

    International Nuclear Information System (INIS)

    Mukherjee, A.; Kamila, S.; Chakravortty, V.

    1999-01-01

    Extraction studies of uranium(VI) by the binary mixture of PC88A and benzimidazole show an antagonistic behavior in the concentration range 10 -5 -10 -6 M of PC88A and 0.005M of benzimidazole. Antagonism is observed due to the deprotonation of PC88A by benzimidazole forming an adduct resulting in the virtual removal of PC88A from the system. (author)

  15. A compact HV supply for field/PC based nuclear instrumentation

    International Nuclear Information System (INIS)

    Manna, A.; Nikhare, D.M.; Madhavi, V.; Bayala, A.K.; Mukhopadhyay, P.K.; Kataria, S.K.

    2001-01-01

    In the recent years, most of the nuclear instruments that were earlier based on NIM Bin standards, are becoming available as PC Add-on cards. This trend is due to the decreasing prices of desktop personal computers and the necessity for automation in radioactivity measurements. This paper describes the design and development of a HV supply module and its PC Add-on card version for field portable/ PC based nuclear instrumentation. The HV supply though being very compact in size meets all the stringent specifications required for detector biasing applications and it has been tested for use with NaI, BF 3 . (author)

  16. Implementation of RS-485 Communication between PLC and PC of Distributed Control System Based on VB

    Science.gov (United States)

    Lian Zhang, Chuan; Da Huang, Zhi; Qing Zhou, Gui; Chong, Kil To

    2015-05-01

    This paper focuses on achieving RS-485 communication between programmable logical controller (PLC) and PC based on visual basic 6.0 (VB6.0) on an experimental automatic production line. Mitsubishi FX2N PLCs and a PC are chosen as slave stations and main station, respectively. Monitoring software is developed using VB6.0 for data input/output, flow control and online parameters setting. As a result, all functions are fulfilled with robust performance. It is concluded from results that one PC can monitor several PLCs using RS-485 communication.

  17. Mutations in the G6PC3 gene cause Dursun syndrome.

    Science.gov (United States)

    Banka, Siddharth; Newman, William G; Ozgül, R Koksal; Dursun, Ali

    2010-10-01

    Dursun syndrome is a triad of familial primary pulmonary hypertension, leucopenia, and atrial septal defect. Here we demonstrate that mutations in G6PC3 cause Dursun syndrome. Mutations in G6PC3 are known to also cause severe congenital neutropenia type 4. Identification of the genetic basis of Dursun syndrome expands the pre-existing knowledge about the phenotypic effects of mutations in G6PC3. We propose that Dursun syndrome should now be considered as a subset of severe congenital neutropenia type 4 with pulmonary hypertension as an important clinical feature. Copyright © 2010 Wiley-Liss, Inc.

  18. State of the art of parallel scientific visualization applications on PC clusters

    International Nuclear Information System (INIS)

    Juliachs, M.

    2004-01-01

    In this state of the art on parallel scientific visualization applications on PC clusters, we deal with both surface and volume rendering approaches. We first analyze available PC cluster configurations and existing parallel rendering software components for parallel graphics rendering. CEA/DIF has been studying cluster visualization since 2001. This report is part of a study to set up a new visualization research platform. This platform consisting of an eight-node PC cluster under Linux and a tiled display was installed in collaboration with Versailles-Saint-Quentin University in August 2003. (author)

  19. On petroleum fluid characterization with the PC-SAFT equation of state

    DEFF Research Database (Denmark)

    Liang, Xiaodong; Yan, Wei; Thomsen, Kaj

    2014-01-01

    The perturbed-chain statistical associating fluid theory (PC-SAFT) equation of state has shown promising results for describing complex phase behaviors and high pressure properties of various systems. It has been proposed as an alternative to the classical cubic equations of state in the petroleum...... industry. It is, however, far from a simple task to develop a sophisticated oil characterization method for the PC-SAFT EOS. In this work, in order to answer some fundamental questions of developing new characterization methods for PC-SAFT, six methods are proposed to estimate the model parameters...

  20. General specifications for the development of a USL/DBMS NASA/PC R and D distributed workstation

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Chum, Frank Y.

    1984-01-01

    The general specifications for the development of a PC-based distributed workstation (PCDWS) for an information storage and retrieval systems environment are defined. This research proposes the development of a PCDWS prototype as part of the University of Southwestern Louisiana Data Base Management System (USL/DBMS) NASA/PC R and D project in the PC-based workstation environment.

  1. Sub-ns triplet state formation by non-geminate recombination in PSBTBT:PC 70 BM and PCPDTBT:PC 60 BM organic solar cells

    KAUST Repository

    Etzold, Fabian

    2015-03-02

    The solid-state morphology and photo-generated charge carrier dynamics in low-bandgap polymer:fullerene bulk heterojunction photovoltaic blends using the donor–acceptor type copolymers PCPDTBT or its silicon-substituted analogue PSBTBT as donors are compared by two-dimensional (2D) solid-state nuclear magnetic resonance (NMR) and femto-to microsecond broadband Vis-NIR transient absorption (TA) pump–probe spectroscopy. The 2D solid-state NMR experiments demonstrate that the film morphology of PCPDTBT:PC60BM blends processed with additives such as octanedithiol (ODT) are similar to those of PSBTBT:PC60BM blends in terms of crystallinity, phase segregation, and interfacial contacts. The TA experiments and analysis of the TA data by multivariate curve resolution (MCR) reveal that after exciton dissociation and free charge formation, fast sub-nanosecond non-geminate recombination occurs which leads to a substantial population of the polymer\\'s triplet state. The extent to which triplet states are formed depends on the initial concentration of free charges, which itself is controlled by the microstructure of the blend, especially in case of PCPDTBT:PC60BM. Interestingly, PSBTBT:PC70BM blends show a higher charge generation efficiency, but less triplet state formation at similar free charge carrier concentrations. This indicates that the solid-state morphology and interfacial structures of PSBTBT:PC70BM blends reduces non-geminate recombination, leading to superior device performance compared to optimized PCPDTBT:PC60BM blends.

  2. Sub-ns triplet state formation by non-geminate recombination in PSBTBT:PC 70 BM and PCPDTBT:PC 60 BM organic solar cells

    KAUST Repository

    Etzold, Fabian; Howard, Ian A.; Forler, Nina; Melnyk, Anton; Andrienko, Denis; Hansen, Michael Ryan; Laquai, Fré dé ric

    2015-01-01

    The solid-state morphology and photo-generated charge carrier dynamics in low-bandgap polymer:fullerene bulk heterojunction photovoltaic blends using the donor–acceptor type copolymers PCPDTBT or its silicon-substituted analogue PSBTBT as donors are compared by two-dimensional (2D) solid-state nuclear magnetic resonance (NMR) and femto-to microsecond broadband Vis-NIR transient absorption (TA) pump–probe spectroscopy. The 2D solid-state NMR experiments demonstrate that the film morphology of PCPDTBT:PC60BM blends processed with additives such as octanedithiol (ODT) are similar to those of PSBTBT:PC60BM blends in terms of crystallinity, phase segregation, and interfacial contacts. The TA experiments and analysis of the TA data by multivariate curve resolution (MCR) reveal that after exciton dissociation and free charge formation, fast sub-nanosecond non-geminate recombination occurs which leads to a substantial population of the polymer's triplet state. The extent to which triplet states are formed depends on the initial concentration of free charges, which itself is controlled by the microstructure of the blend, especially in case of PCPDTBT:PC60BM. Interestingly, PSBTBT:PC70BM blends show a higher charge generation efficiency, but less triplet state formation at similar free charge carrier concentrations. This indicates that the solid-state morphology and interfacial structures of PSBTBT:PC70BM blends reduces non-geminate recombination, leading to superior device performance compared to optimized PCPDTBT:PC60BM blends.

  3. Comportamiento térmico y mecánico de mezclas de PC/PET con altos contenidos de PC

    OpenAIRE

    Cornement, Frédéric

    2006-01-01

    Las mezclas de polímeros tienen un interés científico e industrial considerable. Mezclar es una manera muy eficaz para adaptar las propiedades de los polímeros a diferentes circunstancias. El Poli(Etilén Tereftalato) (PET) y el PoliCarbonato (PC) son dos termoplásticos muy importantes. PC tiene una elevada resistencia al impacto y su resistencia a los solventes se mejora cuando se mezcla con PET. Los dos son poliésteres y pueden reaccionar mediante transesterificación en el fundido p...

  4. A Method for Transferring Photoelectric Photometry Data from Apple II+ to IBM PC

    Science.gov (United States)

    Powell, Harry D.; Miller, James R.; Stephenson, Kipp

    1989-06-01

    A method is presented for transferring photoelectric photometry data files from an Apple II computer to an IBM PC computer in a form which is compatible with the AAVSO Photoelectric Photometry data collection process.

  5. AceDoPC, a structured phospholipid to target the brain with docosahexaenoic acid

    Directory of Open Access Journals (Sweden)

    Lagarde Michel

    2016-01-01

    Full Text Available AceDoPC® is a structured phospholipid or acetyl-LysoPC-DHA made to prevent docosahexaenoic acyl migrating from the sn-2 to sn-1 position of the phospholipid, however keeping the main physical-chemical properties of LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPC® allows DHA crossing a re-constituted blood-brain barrier with higher efficiency than non-esterified DHA or PC-DHA. When injected to blood of rats, AceDoPC® is processed within the brain to deliver DHA to phosphatidyl-choline and -ethanolamine. When injected to rats following the induction of an ischemic stroke, AceDoPC® prevents the extension of brain lesions more efficiently than DHA. Overall, these properties make AceDoPC® a promising phospholipid carrier of DHA to the brain.

  6. PcG and trxG in plants - friends or foes.

    Science.gov (United States)

    Pu, Li; Sung, Zinmay Renee

    2015-05-01

    The highly-conserved Polycomb group (PcG) and trithorax group (trxG) proteins play major roles in regulating gene expression and maintaining developmental states in many organisms. However, neither the recruitment of Polycomb repressive complexes (PRC) nor the mechanisms of PcG and trxG-mediated gene silencing and activation are well understood. Recent progress in Arabidopsis research challenges the dominant model of PRC2-dependent recruitment of PRC1 to target genes. Moreover, evidence indicates that diverse forms of PRC1, with shared components, are a common theme in plants and mammals. Although trxG is known to antagonize PcG, emerging data reveal that trxG can also repress gene expression, acting cooperatively with PcG. We discuss these recent findings and highlight the employment of diverse epigenetic mechanisms during development in plants and animals. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Electrical transport properties of thermally evaporated phthalocyanine (H 2Pc) thin films

    Science.gov (United States)

    El-Nahass, M. M.; Farid, A. M.; Attia, A. A.; Ali, H. A. M.

    2006-08-01

    Thin films of H 2Pc of various thicknesses have been deposited onto glass substrates using thermal evaporation technique at room temperature. The dark electrical resistivity measurements were carried out at different temperatures in the range 298-473 K. An estimation of mean free path ( lo) of charge carriers in H 2Pc thin films was attempted. Measurements of thermoelectric power confirm that H 2Pc thin films behave as a p-type semiconductor. The current density-voltage characteristics of Au/H 2Pc/Au at room temperature showed ohmic conduction mechanism at low voltages. At higher voltages the space-charge-limited conduction (SCLC) accompanied by an exponential trap distribution was dominant. The temperature dependence of current density allows the determination of some essential parameters such as the hole mobility ( μh), the total trap concentration ( Nt), the characteristic temperature ( Tt) and the trap density P( E).

  8. DIOPS: A PC-Based Wave, Tide and Surf Prediction System

    National Research Council Canada - National Science Library

    Allard, Richard; Dykes, James; Kaihatu, James; Wakeham, Dean

    2005-01-01

    The Distributed Integrated Ocean Prediciton System (DIOPS) is a PC-based wave tide and surf prediction system designed to provide DoD accurate and timely surf predictions for essentially any world-wide location...

  9. Performance of PC-based charged particle multi-channel spectrometer utilising particle identification

    International Nuclear Information System (INIS)

    Palla, G.; Sziklai, J.; Trajber, Cs.

    1993-12-01

    A collaterally expandable charged particle spectrometer based on PC control and particle identification is described. A typical system configuration consisting of two channels are used to test the system performance. (author) 7 refs.; 5 figs

  10. Ordered array of CoPc-vacancies filled with single-molecule rotors

    Science.gov (United States)

    Xie, Zheng-Bo; Wang, Ya-Li; Tao, Min-Long; Sun, Kai; Tu, Yu-Bing; Yuan, Hong-Kuan; Wang, Jun-Zhong

    2018-05-01

    We report the highly ordered array of CoPc-vacancies and the single-molecule rotors inside the vacancies. When CoPc molecules are deposited on Cd(0001) at low-temperature, three types of molecular vacancies appeared randomly in the CoPc monolayer. Annealing the sample to higher temperature leads to the spontaneous phase separation and self-organized arrangement of the vacancies. Highly ordered arrays of two-molecule vacancies and single-molecule vacancies have been obtained. In particular, there is a rotating CoPc molecule inside each single-molecule vacancy, which constitutes the array of single-molecule rotors. These results provide a new routine to fabricate the nano-machines on a large scale.

  11. Triplet State Formation in Photovoltaic Blends of DPP-Type Copolymers and PC71BM

    KAUST Repository

    Ochsmann, Julian R.; Chandran, Deepak; Gehrig, Dominik W.; Anwar, Husna; Madathil, Pramod Kandoth; Lee, Kwang-Sup; Laquai, Fré dé ric

    2015-01-01

    The exciton dynamics in pristine films of two structurally related low-bandgap diketopyrrolopyrrole (DPP)-based donor–acceptor copolymers and the photophysical processes in bulk heterojunction solar cells using DPP copolymer:PC71BM blends

  12. Chart of the nuclides. NUCHART for Windows version 1.2, Feb 1995. PC code

    International Nuclear Information System (INIS)

    Osorio, V.; Peraza, H.

    1995-01-01

    The PC package NUCHART is described which displays nuclear decay data, including a search routine for assigning gamma-ray energies to radionuclides. The package is available upon request, costfree, from the IAEA. (author)

  13. Measurement system microdensitometer Joyce-Loebl and computer IBM-PC for quantitative evaluation of autoradiograms

    International Nuclear Information System (INIS)

    Chajecki, T.

    1992-01-01

    The description of measurement system microdensitometer Joyce-Loebl, computer IBM-PC interface are given in the report. This system gives the possibility to save and processing of autoradiograms quantity data. (author). 2 refs, 14 figs, 2 tabs

  14. FASTRAN II - FATIGUE CRACK GROWTH STRUCTURAL ANALYSIS (IBM PC VERSION)

    Science.gov (United States)

    Newman, J. C.

    1994-01-01

    loads may be either tensile or compressive. Several standardized aircraft flight-load histories, such as TWIST, Mini-TWIST, FALSTAFF, Inverted FALSTAFF, Felix and Gaussian, are included as options. FASTRAN II also includes two other methods that will help the user input spectrum load histories. The two methods are: (1) a list of stress points, and (2) a flight-by-flight history of stress points. Examples are provided in the user manual. Developed as a research program, FASTRAN II has successfully predicted crack growth in many metallic materials under various aircraft spectrum loading. A computer program DKEFF which is a part of the FASTRAN II package was also developed to analyze crack growth rate data from laboratory specimens to obtain the effective stress-intensity factor against crack growth rate relations used in FASTRAN II. FASTRAN II is written in standard FORTRAN 77. It has been successfully compiled and implemented on Sun4 series computers running SunOS and on IBM PC compatibles running MS-DOS using the Lahey F77L FORTRAN compiler. Sample input and output data are included with the FASTRAN II package. The UNIX version requires 660K of RAM for execution. The standard distribution medium for the UNIX version (LAR-14865) is a .25 inch streaming magnetic tape cartridge in UNIX tar format. It is also available on a 3.5 inch diskette in UNIX tar format. The standard distribution medium for the MS-DOS version (LAR-14944) is a 5.25 inch 360K MS-DOS format diskette. The contents of the diskette are compressed using the PKWARE archiving tools. The utility to unarchive the files, PKUNZIP.EXE, is included. The program was developed in 1984 and revised in 1992. Sun4 and SunOS are trademarks of Sun Microsystems, Inc. IBM PC is a trademark of International Business Machines Corp. MS-DOS is a trademark of Microsoft, Inc. F77L is a trademark of the Lahey Computer Systems, Inc. UNIX is a registered trademark of AT&T Bell Laboratories. PKWARE and PKUNZIP are trademarks of PKWare

  15. Human prostatic cancer cells, PC3, elaborate mitogenic activity which selectively stimulates human bone cells

    International Nuclear Information System (INIS)

    Perkel, V.S.; Mohan, S.; Herring, S.J.; Baylink, D.J.; Linkhart, T.A.

    1990-01-01

    Prostatic cancer typically produces osteoblastic metastases which are not attended by marrow fibrosis. In the present study we sought to test the hypothesis that prostatic cancer cells produce factor(s) which act selectively on human osteoblasts. Such a paracrine mechanism would explain the observed increase in osteoblasts, unaccompanied by an increase in marrow fibroblasts. To test this hypothesis we investigated the mitogenic activity released by the human prostatic tumor cell line, PC3. PC3 cells have been reported previously to produce mitogenic activity for cells that was relatively specific for rat osteoblasts compared to rat fibroblasts. However, the effects of this activity on human cells has not been examined previously. PC3-conditioned medium (CM) (5-50 micrograms CM protein/ml) stimulated human osteoblast proliferation by 200-950% yet did not stimulate human fibroblast proliferation ([3H]thymidine incorporation). PC3 CM also increased cell numbers in human osteoblast but not fibroblast cell cultures. To determine whether the osteoblast-specific mitogenic activity could be attributed to known bone growth factors, specific assays for these growth factors were performed. PC3 CM contained 10 pg insulin-like growth factor (IGF) I, less than 2 pg IGF II, 54 pg basic fibroblast growth factor, and 16 pg transforming growth factor beta/microgram CM protein. None of these growth factors alone or in combination could account for the observed osteoblast-specific PC3 cell-derived mitogenic activity. Furthermore, when 5 micrograms/ml PC3 CM was tested in combination with maximally effective concentrations of either basic fibroblast growth factor, IGF I, IGF II, or transforming growth factor beta, it produced an additive effect suggesting that PC3 CM stimulates osteoblast proliferation by a mechanism independent of these bone mitogens

  16. A PC-Linux-based data acquisition system for the STAR TOFp detector

    International Nuclear Information System (INIS)

    Liu Zhixu; Liu Feng; Zhang Bingyun

    2003-01-01

    Commodity hardware running the open source operating system Linux is playing various important roles in the field of high energy physics. This paper describes the PC-Linux-based Data Acquisition System of STAR TOFp detector. It is based on the conventional solutions with front-end electronics made of NIM and CAMAC modules controlled by a PC running Linux. The system had been commissioned into the STAR DAQ system, and worked successfully in the second year of STAR physics runs

  17. Development a computer codes to couple PWR-GALE output and PC-CREAM input

    Science.gov (United States)

    Kuntjoro, S.; Budi Setiawan, M.; Nursinta Adi, W.; Deswandri; Sunaryo, G. R.

    2018-02-01

    Radionuclide dispersion analysis is part of an important reactor safety analysis. From the analysis it can be obtained the amount of doses received by radiation workers and communities around nuclear reactor. The radionuclide dispersion analysis under normal operating conditions is carried out using the PC-CREAM code, and it requires input data such as source term and population distribution. Input data is derived from the output of another program that is PWR-GALE and written Population Distribution data in certain format. Compiling inputs for PC-CREAM programs manually requires high accuracy, as it involves large amounts of data in certain formats and often errors in compiling inputs manually. To minimize errors in input generation, than it is make coupling program for PWR-GALE and PC-CREAM programs and a program for writing population distribution according to the PC-CREAM input format. This work was conducted to create the coupling programming between PWR-GALE output and PC-CREAM input and programming to written population data in the required formats. Programming is done by using Python programming language which has advantages of multiplatform, object-oriented and interactive. The result of this work is software for coupling data of source term and written population distribution data. So that input to PC-CREAM program can be done easily and avoid formatting errors. Programming sourceterm coupling program PWR-GALE and PC-CREAM is completed, so that the creation of PC-CREAM inputs in souceterm and distribution data can be done easily and according to the desired format.

  18. Physical and mechanical properties of mortars containing PET and PC waste aggregates.

    Science.gov (United States)

    Hannawi, Kinda; Kamali-Bernard, Siham; Prince, William

    2010-11-01

    Non-biodegradable plastic aggregates made of polycarbonate (PC) and polyethylene terephthalate (PET) waste are used as partial replacement of natural aggregates in mortar. Various volume fractions of sand 3%, 10%, 20% and 50% are replaced by the same volume of plastic. This paper investigates the physical and mechanical properties of the obtained composites. The main results of this study show the feasibility of the reuse of PC and PET waste aggregates materials as partial volume substitutes for natural aggregates in cementitious materials. Despite of some drawbacks like a decrease in compressive strength, the use of PC and PET waste aggregates presents various advantages. A reduction of the specific weight of the cementitious materials and a significant improvement of their post-peak flexural behaviour are observed. The calculated flexural toughness factors increase significantly with increasing volume fraction of PET and PC-aggregates. Thus, addition of PC and PET plastic aggregates in cementitious materials seems to give good energy absorbing materials which is very interesting for several civil engineering applications like structures subjected to dynamic or impact efforts. The present study has shown quite encouraging results and opened new way for the recycling of PC waste aggregate in cement and concrete composites. Copyright © 2010 Elsevier Ltd. All rights reserved.

  19. Protective Effect of Quercetin against Oxidative Stress-Induced Cytotoxicity in Rat Pheochromocytoma (PC-12 Cells

    Directory of Open Access Journals (Sweden)

    Dengke Bao

    2017-07-01

    Full Text Available Oxidative stress has been implicated in the pathogenesis of many kinds of neurodegenerative disorders, particularly Parkinson’s disease. Quercetin is a bioflavonoid found ubiquitously in fruits and vegetables, and has antioxidative activity. However, the underlying mechanism of the antioxidative effect of quercetin in neurodegenerative diseases has not been well explored. Here, we investigated the antioxidative effect and underlying molecular mechanisms of quercetin on PC-12 cells. We found that PC-12 cells pretreated with quercetin exhibited an increased cell viability and reduced lactate dehydrogenase (LDH release when exposed to hydrogen peroxide (H2O2. The significantly-alleviated intracellular reactive oxygen species (ROS, malondialdehyde (MDA, and lipoperoxidation of the cell membrane of PC-12 cells induced by H2O2 were observed in the quercetin pretreated group. Furthermore, quercetin pretreatment markedly reduced the apoptosis of PC-12 cells and hippocampal neurons. The inductions of antioxidant enzyme catalase (CAT, superoxide dismutase (SOD, and glutathione peroxidase (GSH-Px in PC-12 cells exposed to H2O2 were significantly reduced by preatment with quercetin. In addition, quercetin pretreatment significantly increased Bcl-2 expression, and reduced Bax, cleaved caspase-3 and p53 expressions. In conclusion, this study demonstrated that quercetin exhibited a protective effect against oxidative stress-induced apoptosis in PC-12 cells. Our findings suggested that quercetin may be developed as a novel therapeutic agent for neurodegenerative diseases induced by oxidative stress.

  20. Protective Effect of Quercetin against Oxidative Stress-Induced Cytotoxicity in Rat Pheochromocytoma (PC-12) Cells.

    Science.gov (United States)

    Bao, Dengke; Wang, Jingkai; Pang, Xiaobin; Liu, Hongliang

    2017-07-06

    Oxidative stress has been implicated in the pathogenesis of many kinds of neurodegenerative disorders, particularly Parkinson's disease. Quercetin is a bioflavonoid found ubiquitously in fruits and vegetables, and has antioxidative activity. However, the underlying mechanism of the antioxidative effect of quercetin in neurodegenerative diseases has not been well explored. Here, we investigated the antioxidative effect and underlying molecular mechanisms of quercetin on PC-12 cells. We found that PC-12 cells pretreated with quercetin exhibited an increased cell viability and reduced lactate dehydrogenase (LDH) release when exposed to hydrogen peroxide (H₂O₂). The significantly-alleviated intracellular reactive oxygen species (ROS), malondialdehyde (MDA), and lipoperoxidation of the cell membrane of PC-12 cells induced by H₂O₂ were observed in the quercetin pretreated group. Furthermore, quercetin pretreatment markedly reduced the apoptosis of PC-12 cells and hippocampal neurons. The inductions of antioxidant enzyme catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) in PC-12 cells exposed to H₂O₂ were significantly reduced by preatment with quercetin. In addition, quercetin pretreatment significantly increased Bcl-2 expression, and reduced Bax, cleaved caspase-3 and p53 expressions. In conclusion, this study demonstrated that quercetin exhibited a protective effect against oxidative stress-induced apoptosis in PC-12 cells. Our findings suggested that quercetin may be developed as a novel therapeutic agent for neurodegenerative diseases induced by oxidative stress.

  1. Morphological, structural and optical properties of MEH-PPV: PC70BM nanocomposite film

    Science.gov (United States)

    Mhamdi, Asya; Sweii, Fatma ben Slama; Saidi, Hamza; Saidi, Faouzi; Bouazizi, Abdelaziz

    2018-05-01

    In this report, the influence of annealing temperature and spin coating speed on the structural and morphological properties of a blend of poly (2-methoxy-5-(2-ethyl-oxy)-p-phenylene-vinylene) (MEH-PPV) and [6-6]-phenyl-C71-butyric acid methyl ester (PC70BM) layer has been investigated. The photoactive layer (MEH-PPV: PC70BM) was deposited on ZnO film deposited on top of indium tin oxide (ITO) substrate by spin-coating. The effect of spin coating speed via atomic force microscope (AFM) leads to conclude that high speed is favorable for a good homogeneity of the film surface and good aggregates dispersion. The optimized structure was studied by varying the annealing temperatures using X-ray diffraction (XRD). The XRD analysis indicates that annealing treatment promoted the ordered aggregation and crystallization of MEH-PPV: PC70BM films. Indeed, the blend ratio effect on the optical properties of MEH-PPV: PC70BM thin film was investigated. While, the effect of incorporation of PC70BM on the optical properties was studied using UV-Vis and photoluminescence (PL) measurement. We conclude that MEH-PPV: PC70BM (1:3) film leads to high charge transfer rate.

  2. Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins.

    Science.gov (United States)

    Khan, Sheraz; Iqbal, Mazhar; Tariq, Muhammad; Baig, Shahid M; Abbas, Wasim

    2018-01-01

    HIV-1 latency allows the virus to persist until reactivation, in a transcriptionally silent form in its cellular reservoirs despite the presence of effective cART. Such viral persistence represents a major barrier to HIV eradication since treatment interruption leads to rebound plasma viremia. Polycomb group (PcG) proteins have recently got a considerable attention in regulating HIV-1 post-integration latency as they are involved in the repression of proviral gene expression through the methylation of histones. This epigenetic regulation plays an important role in the establishment and maintenance of HIV-1 latency. In fact, PcG proteins act in complexes and modulate the epigenetic signatures of integrated HIV-1 promoter. Key role played by PcG proteins in the molecular control of HIV-1 latency has led to hypothesize that PcG proteins may represent a valuable target for future HIV-1 therapy in purging HIV-1 reservoirs. In this regard, various small molecules have been synthesized or explored to specifically block the epigenetic activity of PcG. In this review, we will highlight the possible therapeutic approaches to achieve either a functional or sterilizing cure of HIV-1 infection with special focus on histone methylation by PcG proteins together with current and novel pharmacological approaches to reactivate HIV-1 from latency that could ultimately lead towards a better clearance of viral latent reservoirs.

  3. Thin film pc-Si by aluminium induced crystallization on metallic substrate

    Directory of Open Access Journals (Sweden)

    Cayron C.

    2013-04-01

    Full Text Available Thin film polycrystalline silicon (pc-Si on flexible metallic substrates is promising for low cost production of photovoltaic solar cells. One of the attractive methods to produce pc-Si solar cells consists in thickening a large-grained seed layer by epitaxy. In this work, the deposited seed layer is made by aluminium induced crystallization (AIC of an amorphous silicon (a-Si thin film on metallic substrates (Ni/Fe alloy initially coated with a tantalum nitride (TaN conductive diffusion barrier layer. Effect of the thermal budget on the AIC grown pc-Si seed layer was investigated in order to optimize the process (i.e. the quality of the pc-Si thin film. Structural and optical characterizations were carried out using optical microscopy, μ-Raman and Electron Backscatter Diffraction (EBSD. At optimal thermal annealing conditions, the continuous AIC grown pc-Si thin film showed an average grain size around 15 μm. The grains were preferably (001 oriented which is favorable for its epitaxial thickening. This work proves the feasibility of the AIC method to grow large grains pc-Si seed layer on TaN coated metal substrates. These results are, in terms of grains size, the finest obtained by AIC on metallic substrates.

  4. Compartment-Specific Biosensors Reveal a Complementary Subcellular Distribution of Bioactive Furin and PC7

    Directory of Open Access Journals (Sweden)

    Pierpaolo Ginefra

    2018-02-01

    Full Text Available Furin trafficking, and that of related proprotein convertases (PCs, may regulate which substrates are accessible for endoproteolysis, but tools to directly test this hypothesis have been lacking. Here, we develop targeted biosensors that indicate Furin activity in endosomes is 10-fold less inhibited by decanoyl-RVKR-chloromethylketone and enriched >3-fold in endosomes compared to the trans-Golgi network (TGN. Endogenous PC7, which resists this inhibitor, was active in distinct vesicles. Only overexpressed PC7 activity reached the cell surface, endosomes, and the TGN. A PLC motif in the cytosolic tail of PC7 was dispensable for endosomal activity, but it was specifically required for TGN recycling and to rescue proActivin-A cleavage in Furin-depleted B16F1 melanoma cells. In sharp contrast, PC7 complemented Furin in cleaving Notch1 independently of PLC-mediated TGN access. Our study provides a proof in principle that compartment-specific biosensors can be used to gain insight into the regulation of PC trafficking and to map the tropism of PC-specific inhibitors.

  5. The Weathering Study of PC/ASA Alloy For Automotive Exterior Applications

    Directory of Open Access Journals (Sweden)

    Sinan Öztürk

    2017-10-01

    Full Text Available Polycarbonates (PC are used in automotive industry due to high physical and mechanical properties like high impact resistance and ductility. Polycarbonates are blended with ABS (Acrylonitrile-Butadiene-Styrene and ASA (Acrylonitrile-Styrene-Acrylate terpolymers for interior and exterior applications of automotive components to achieve good physical and mechanical properties. Other reason for choosing such alloys for interior applications is the IZOD impact resistance requirement higher than 40kJ/m2. Recently, grades of PC/ASA with UV stabilized are developed for non-painted exterior applications. The aim of our study is to investigate whether new developed PC/ASA could be chosen for exterior applications of automotive industry. In this study, the samples are prepared from injection molding and the weathering performance of PC/ASA was tested by a weather-o-meter for 1500h at a total of 1890 kJ/m2 at 340nm with a cut-off filter at λ<290nm. The results are evaluated by FT-IR, DSC, TGA and SEM. It has been observed that UV degradation of PC/ASA leads to several major changes in its IR spectrum like broad bands occurred in the hydroxyl region around 3300 cm-1, and carbonyl stretching region increased around 1728 cm-1. The main degradations were based on photo-oxidation and photo-Fries rearrangement of PC. In our study, the photo-oxidation was followed by the color shift to yellowing of the polymer.

  6. Approach to Improve Speed of Sound Calculation within PC-SAFT Framework

    DEFF Research Database (Denmark)

    Liang, Xiaodong; Maribo-Mogensen, Bjørn; Thomsen, Kaj

    2012-01-01

    An extensive comparison of SRK, CPA and PC-SAFT for speed of sound in normal alkanes has been performed. The results reveal that PC-SAFT captures the curvature of speed of sound better than cubic EoS but the accuracy is not satisfactory. Two approaches have been proposed to improve PC-SAFT’s accu...... keeping acceptable accuracy for the primary properties, i.e. vapor pressure (2.1%) and liquid density (1.5%). The two approaches have also been applied to methanol, and both give very good results.......An extensive comparison of SRK, CPA and PC-SAFT for speed of sound in normal alkanes has been performed. The results reveal that PC-SAFT captures the curvature of speed of sound better than cubic EoS but the accuracy is not satisfactory. Two approaches have been proposed to improve PC......-SAFT’s accuracy for speed of sound: (i) putting speed of sound data into parameter estimation; (ii) putting speed of sound data into both universal constants regression and parameter estimation. The results have shown that the second approach can significantly improve the speed of sound (3.2%) prediction while...

  7. Training HBCU Faculty and Students in Prostate Cancer (PC) Research: Signal Transduction and Receptor-Inhibitor Interactions in the Progress of PC

    National Research Council Canada - National Science Library

    Wiese, Thomas E; Klassen, R. B

    2007-01-01

    .... One new project has been developed and is involving students. (3) To establish a long-term collaborative relationship between Xavier University and the TCC in PC research. XU faculty in the program are now members of the Tulane Cancer Center and involved in weekly seminars and focus group meetings.

  8. Training HBCU Faculty and Students in Prostate Cancer (PC) Research: Signal Transduction and Receptor-Inhibitor Interactions in the Progress of PC

    National Research Council Canada - National Science Library

    Wiese, Thomas E; Klassen, R. B

    2008-01-01

    .... One new project has been developed and is involving students. (3) To establish a long-term collaborative relationship between Xavier University and the TCC in PC research. XU faculty in the program are now members of the Tulane Cancer Center and involved in weekly seminars and focus group meetings.

  9. Collagenolytic serine protease PC and trypsin PC from king crab Paralithodes camtschaticus: cDNA cloning and primary structure of the enzymes

    Directory of Open Access Journals (Sweden)

    Rebrikov Denis V

    2004-01-01

    Full Text Available Abstract Background In this paper, we describe cDNA cloning of a new anionic trypsin and a collagenolytic serine protease from king crab Paralithodes camtschaticus and the elucidation of their primary structures. Constructing the phylogenetic tree of these enzymes was undertaken in order to prove the evolutionary relationship between them. Results The mature trypsin PC and collagenolytic protease PC contain 237 (Mcalc 24.8 kDa and 226 amino acid residues (Mcalc 23.5 kDa, respectively. Alignments of their amino acid sequences revealed a high degree of the trypsin PC identity to the trypsin from Penaeus vannamei (approximately 70% and of the collagenolytic protease PC identity to the collagenase from fiddler crab Uca pugilator (76%. The phylogenetic tree of these enzymes was constructed. Conclusions Primary structures of the two mature enzymes from P. camtschaticus were obtained and compared with those of other proteolytic proteins, including some enzymes from brachyurans. A phylogenetic analysis was also carried out. These comparisons revealed that brachyurins are closely related to their vertebrate and bacterial congeners, occupy an intermediate position between them, and their study significantly contributes to the understanding of the evolution and function of serine proteases.

  10. Investigation on vibrational dampers for cables of Tsurumi Tsubasa bridge; Tsurumi tsubasabashi no keburu seishin hoshiki ni kansuru jisho

    Energy Technology Data Exchange (ETDEWEB)

    Takano, H.; Ogasawara, M.; Shimosato, T. [Metropolitan Public Corp., Tokyo (Japan); Yamada, H. [Yokohama National Univ. (Japan)] Murakami, T. [NKK Corp., Tokyo (Japan). Applied Technology Research Center

    1998-03-20

    In a long cable-stayed bridge, countermeasure against wind induced vibration should be often taken at the same time together with the measure against angular bent phenomena (phenomena in which secondary bending stress is generated on the front of fixing socket by live load). The conventional countermeasure is a combined use of buffer rubber and dampers. This study points out problems in the conventional countermeasure on the application to the cables of the Tsurumi Tsubasa Bridge and combination of dampers and angular bending buffer device is examined. The result shows that a combined use of high-damping rubber and oil dampers enables installation of the dampers in a lower position while maintaining the performance and is excellent in the easiness in installation and maintenance and in aesthetic view. This system was applied to the Tsurumi Tsubasa Bridge and the effectiveness on damping and angular bending relaxation was confirmed through the model tests, and vibration tests and field observation on the cables. 9 refs., 20 figs., 7 tabs.

  11. The white dwarfs within 25 pc of the Sun: Kinematics and spectroscopic subtypes

    Energy Technology Data Exchange (ETDEWEB)

    Sion, Edward M.; McCook, George P.; Wasatonic, Richard; Myszka, Janine [Department of Astronomy and Astrophysics, Villanova University, Villanova, PA 19085 (United States); Holberg, J. B. [Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 75201 (United States); Oswalt, Terry D., E-mail: edward.sion@villanova.edu, E-mail: george.mccook@villanova.edu, E-mail: richard.wasatonic@villanova.edu, E-mail: janine.myszka@villanova.edu, E-mail: holberg@vega.lpl.arizona.edu, E-mail: toswalt@fit.edu [Department of Physics and Space Sciences, Florida Institute of Technology, Melbourne, FL 19085 (United States)

    2014-06-01

    We present the fractional distribution of spectroscopic subtypes, range and distribution of surface temperatures, and kinematical properties of the white dwarfs (WDs) within 25 pc of the Sun. There is no convincing evidence of halo WDs in the total 25 pc sample of 224 WDs. There is also little to suggest the presence of genuine thick disk subcomponent members within 25 pc. It appears that the entire 25 pc sample likely belongs to the thin disk. We also find no significant kinematic differences with respect to spectroscopic subtypes. The total DA to non-DA ratio of the 25 pc sample is 1.8, a manifestation of deepening envelope convection, which transforms DA stars with sufficiently thin H surface layers into non-DAs. We compare this ratio with the results of other studies. We find that at least 11% of the WDs within 25 pc of the Sun (the DAZ and DZ stars) have photospheric metals that likely originate from accretion of circumstellar material (debris disks) around them. If this interpretation is correct, then it suggests the possibility that a similar percentage have planets, asteroid-like bodies, or debris disks orbiting them. Our volume-limited sample reveals a pileup of DC WDs at the well-known cutoff in DQ WDs at T {sub eff} ∼ 6000 K. Mindful of small number statistics, we speculate on its possible evolutionary significance. We find that the incidence of magnetic WDs in the 25 pc sample is at least 8% in our volume-limited sample, dominated by cool WDs. We derive approximate formation rates of DB and DQ degenerates and present a preliminary test of the evolutionary scenario that all cooling DB stars become DQ WDs via helium convective dredge-up with the diffusion tail of carbon extending upward from their cores.

  12. Construction and identification of eukaryotic expression vector of pcDNA3-UHRF1

    International Nuclear Information System (INIS)

    Li Xinli; Zhu Ran; Zhu Wei; Fan Saijun; Meng Qinghui

    2011-01-01

    Objective: To generate eukaryotic expression vector of pcDNA3-UHRF1(ubiquitin-like, containing PHD and RING finger domains 1, UHRF1) and testify its expression in breast cancer cells MDA-MB-231. Methods: A 2.3 kb cDNA fragment was amplified from the total RNA of the human breast cancer cells MCF-7 by the RT-PCR method and was cloned into the plasmid pcDNA3. The vector was identified by the double digestion with restriction enzymes Kpn I and Xho I and was sequenced. The cDNA of UHRF1 was transfected into human breast cancer cells MDA-MB-231 by Lipofactamin2000. The positive clones were selected by G418. The expression of the UHRF1 was detected by RT-PCR and Western blot analysis. Results: The recombinant eukaryotic expression vector pcDNA3-UHRF1 was digested with Kpn I and BamH I, and the electrophoresis of the digested products showed two fragments; 2.3kb fragment of UHRF1 and 5.4 kb fragment of pcDNA3, and the sequence inserted was identical to the published sequence. The MDA-MB-231 cells transfected with the pcDNA3-UHRF1 plasmid expressed a high level of the UHRF1 mRNA and protein. Conclusion: The recombinant eukaryotic cell expression vector of pcDNA3-UHRF1 is constructed successfully. The recombinant plasmid pcDNA3-UHRF1 can provide a very useful tool and lay an important foundation for the research on the function of UHRF1. (authors)

  13. Estimation of Polar Cap Potential and the Role of PC Index

    Directory of Open Access Journals (Sweden)

    Ga-Hee Moon

    2012-09-01

    Full Text Available Polar cap potential has long been considered as an indicator for the amount of energy flowing in the magnetosphere-ionosphere system. Thus, the estimation of polar cap potential is important to understand the physical process of the magnetosphere. To estimate the polar cap potential in the Northern Hemisphere, merging electric field by Kan & Lee (1979 is adopted. Relationships between the PC index and calculated merging electric field (E* are examined during full-time and storm-time periods separately. For this purpose Dst, AL, and PC indices and solar wind data are utilized during the period from 1996-2003. From this linear relationship, polar cap potential (Φ* is estimated using the formula by Doyle & Burke (1983. The values are represented as 58.1 ± 26.9 kV for the full-time period and 123.7 ± 84.1 kV for a storm-time period separately. Considering that the average value of polar cap potential of Doyle & Burke (1983 is about 47 kV during moderately quiet intervals with the S3-2 measurements, these results are similar to such. The monthly averaged variation of Dst, AL, and PC indices are then compared. The Dst and AL indices show distinct characteristics with peaks during equinoctial season whereas the average PC index according to the month shows higher values in autumn than in spring. The monthly variations of the linear correlation coefficients between solar wind parameters and geomagnetic indices are also examined. The PC-AL linear correlation coefficient is highest, being 0.82 with peaks during the equinoctial season. As with the AL index, the PC index may also prove useful for predicting the intensity of an auroral substorm. Generally, the linear correlation coefficients are shown low in summer due to conductance differences and other factors. To assess the role of the PC index during the recovery phase of a storm, the relation between the cumulative PC index and the duration is examined. Although the correlation coefficient lowers

  14. Organic Photovoltaic Cells Based on PbPc Nanocolumns Prepared by Glancing Angle Deposition

    Directory of Open Access Journals (Sweden)

    Yang Liu

    2013-01-01

    Full Text Available Organic small material lead phthalocyanine (PbPc nanocolumns were prepared via glancing angle deposition (GLAD on indium tin oxide (ITO coated glass substrates. Organic electron acceptor materials fullerene (C60 was evaporated onto the nanocolumn PbPc thin films to prepare heterojunction structure ITO/PbPc/C60/Bphen/Al organic photovoltaic cells (OPVs. It is worthwhile to mention that C60 molecules firstly fill the voids between PbPc nanocolumns and then form impact C60 layer. The interpenetrating electron donor/acceptor structure effectively enhances interface between electron donor and electron acceptor, which is beneficial to exciton dissociation. The short circuit current density (Jsc of organic photovoltaic devices (OPVs based on PbPc nanocolumn was increased from 1.19 mA/cm2 to 1.74 mA/cm2, which should be attributed to the increase of interface between donor and acceptor. The effect of illumination intensity on the performance of OPVs was investigated by controlling the distance between light source and sample, and the Jsc of two kind of OPVs was increased along with the increase of illumination intensity.

  15. A PC based 8K multichannel analyzer [Paper No.: I2

    International Nuclear Information System (INIS)

    Bahere, A.R.; Vaidya, P.P.; Tabib, J.D.; Jha, Kuldip

    1993-01-01

    This paper describes a PC add on MCA card for nuclear spectroscopy applications. It consists of a 8K nuclear ADC, control logic and 8K * 24 bit dual ported histogram memory. The integral card assembly plugs into a single I/O expansion slot of the IBM-PC XT/AT or any compatible PC. This together with the data acquisition and processing software package, developed in Turbo C transforms the PC into a powerful Multichannel Analyzer. In the design of the MCA card, the PC interface, sequencers and control logic is implemented using programmable logic devices in order to achieve compact, efficient and reliable design. The dual ported 8K * 24 bit histogram memory is implemented using conventional static memory with external arbitration logic. Built-in ADC is designed around commercially available monolithic successive approximation type ADC chip. The low differential nonlinearity is achieved using an innovative interpolation technique along with Gatti sliding technique. The data acquisition and processing package developed in Turbo C, includes interrupt driven spectrum display driver and a pull down menu based user interface. Data processing features include spectrum smoothing, auto peak search and energy calibration. Separate memory buffers are used for data acquisition and data processing. Thus it is possible to acquire data in the background while analyzing an earlier acquired data. (author). 2 refs., 4 figs

  16. Gene Expression in Class 2 Integrons Is SOS-Independent and Involves Two Pc Promoters.

    Science.gov (United States)

    Jové, Thomas; Da Re, Sandra; Tabesse, Aurore; Gassama-Sow, Amy; Ploy, Marie-Cécile

    2017-01-01

    Integrons are powerful bacterial genetic elements that permit the expression and dissemination of antibiotic-resistance gene cassettes. They contain a promoter Pc that allows the expression of gene cassettes captured through site-specific recombination catalyzed by IntI, the integron-encoded integrase. Class 1 and 2 integrons are found in both clinical and environmental settings. The regulation of intI and of Pc promoters has been extensively studied in class 1 integrons and the regulatory role of the SOS response on intI expression has been shown. Here we investigated class 2 integrons. We characterized the P intI2 promoter and showed that intI2 expression is not regulated via the SOS response. We also showed that, unlike class 1 integrons, class 2 integrons possess not one but two active Pc promoters that are located within the attI2 region that seem to contribute equally to gene cassette expression. Class 2 integrons mostly encode an inactive truncated integrase, but the rare class 2 integrons that encode an active integrase are associated with less efficient Pc2 promoter variants. We propose an evolutionary model for class 2 integrons in which the absence of repression of the integrase gene expression led to mutations resulting in either inactive integrase or Pc variants of weaker activity, thereby reducing the potential fitness cost of these integrons.

  17. Phase II enzyme induction by a carotenoid, lutein, in a PC12D neuronal cell line

    International Nuclear Information System (INIS)

    Miyake, Seiji; Kobayashi, Saori; Tsubota, Kazuo; Ozawa, Yoko

    2014-01-01

    Highlights: • Lutein reduced ROS levels in a PC12D neuronal cell line. • Lutein induced mRNAs of phase II antioxidative enzymes in PC12D neuronal cells. • Lutein increased protein levels of HO-1, SOD2, and NQO-1 in PC12D neuronal cells. • Lutein had no effect on intranuclear Nrf2 levels in PC12D neuronal cells. • Lutein did not activate potential upstream Nrf2 nuclear translocation pathways. - Abstract: The mechanism by which lutein, a carotenoid, acts as an antioxidant in retinal cells is still not fully understood. Here, lutein treatment of a neuronal cell line (PC12D) immediately resulted in reduced intracellular ROS levels, implying that it has a direct role in ROS scavenging. Significantly, lutein treatment also induced phase II antioxidative enzyme expression, probably via a nuclear factor-like 2 (Nrf2) independent pathway. This latter mechanism could explain why lutein acts diversely to protect against oxidative/cytotoxic stress, and why it is physiologically involved in the human neural tissue, such as the retina

  18. Development of a PC code package for the analysis of research and power reactors

    International Nuclear Information System (INIS)

    Urli, N.

    1992-06-01

    Computer codes available for performing reactor physics calculations for nuclear research reactors and power reactors are normally suited for running on mainframe computers. With the fast development in speed and memory of the PCs and affordable prices it became feasible to develop PC versions of commonly used codes. The present work performed under an IAEA sponsored research contract has successfully developed a code package for running on a PC. This package includes a cross-section generating code PSU-LEOPARD and 2D and 1D spatial diffusion codes, MCRAC and MCYC 1D. For adapting PSU-LEOPARD for a PC, the binary library has been reorganized to decimal form, upgraded to FORTRAN-77 standard and arrays and subroutines reorganized to conform to PC compiler. Similarly PC version of MCRAC for FORTRAN-77 and 1D code MCYC 1D have been developed. Tests, verification and bench mark results show excellent agreement with the results obtained from mainframe calculations. The execution speeds are also very satisfactory. 12 refs, 4 figs, 3 tabs

  19. NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation

    Directory of Open Access Journals (Sweden)

    Labhart Paul

    2007-05-01

    Full Text Available Abstract Background p53 is recognized as a critical regulator of the cell cycle and apoptosis. Mounting evidence also suggests a role for p53 in differentiation of cells including neuronal precursors. We studied the transcriptional role of p53 during nerve growth factor-induced differentiation of the PC12 line into neuron-like cells. We hypothesized that p53 contributed to PC12 differentiation through the regulation of gene targets distinct from its known transcriptional targets for apoptosis or DNA repair. Results Using a genome-wide chromatin immunoprecipitation cloning technique, we identified and validated 14 novel p53-regulated genes following NGF treatment. The data show p53 protein was transcriptionally activated and contributed to NGF-mediated neurite outgrowth during differentiation of PC12 cells. Furthermore, we describe stimulus-specific regulation of a subset of these target genes by p53. The most salient differentiation-relevant target genes included wnt7b involved in dendritic extension and the tfcp2l4/grhl3 grainyhead homolog implicated in ectodermal development. Additional targets included brk, sdk2, sesn3, txnl2, dusp5, pon3, lect1, pkcbpb15 and other genes. Conclusion Within the PC12 neuronal context, putative p53-occupied genomic loci spanned the entire Rattus norvegicus genome upon NGF treatment. We conclude that receptor-mediated p53 transcriptional activity is involved in PC12 differentiation and may suggest a contributory role for p53 in neuronal development.

  20. Phase II enzyme induction by a carotenoid, lutein, in a PC12D neuronal cell line

    Energy Technology Data Exchange (ETDEWEB)

    Miyake, Seiji [Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582 (Japan); Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582 (Japan); Wakasa Seikatsu Co., Ltd., 134 Chudoujiminami-cho, Shimogyo-ku, Kyoto 600-8813 (Japan); Kobayashi, Saori [Wakasa Seikatsu Co., Ltd., 134 Chudoujiminami-cho, Shimogyo-ku, Kyoto 600-8813 (Japan); Tsubota, Kazuo [Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582 (Japan); Ozawa, Yoko, E-mail: ozawa@a5.keio.jp [Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582 (Japan); Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582 (Japan)

    2014-04-04

    Highlights: • Lutein reduced ROS levels in a PC12D neuronal cell line. • Lutein induced mRNAs of phase II antioxidative enzymes in PC12D neuronal cells. • Lutein increased protein levels of HO-1, SOD2, and NQO-1 in PC12D neuronal cells. • Lutein had no effect on intranuclear Nrf2 levels in PC12D neuronal cells. • Lutein did not activate potential upstream Nrf2 nuclear translocation pathways. - Abstract: The mechanism by which lutein, a carotenoid, acts as an antioxidant in retinal cells is still not fully understood. Here, lutein treatment of a neuronal cell line (PC12D) immediately resulted in reduced intracellular ROS levels, implying that it has a direct role in ROS scavenging. Significantly, lutein treatment also induced phase II antioxidative enzyme expression, probably via a nuclear factor-like 2 (Nrf2) independent pathway. This latter mechanism could explain why lutein acts diversely to protect against oxidative/cytotoxic stress, and why it is physiologically involved in the human neural tissue, such as the retina.

  1. LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes

    Directory of Open Access Journals (Sweden)

    Janne Oestvang

    2011-01-01

    Full Text Available Oxidized low-density lipoproteins (LDLs play an important role during the development of atherosclerosis characterized by intimal inflammation and macrophage accumulation. A key component of LDL is lysophosphatidylcholine (lysoPC. LysoPC is a strong proinflammatory mediator, and its mechanism is uncertain, but it has been suggested to be mediated via the platelet activating factor (PAF receptor. Here, we report that PAF triggers a pertussis toxin- (PTX- sensitive intracellular signaling pathway leading to sequential activation of sPLA2, PLD, cPLA2, and AA release in human-derived monocytes. In contrast, lysoPC initiates two signaling pathways, one sequentially activating PLD and cPLA2, and a second parallel PTX-sensitive pathway activating cPLA2 with concomitant activation of sPLA2, all leading to AA release. In conclusion, lysoPC and PAF stimulate AA release by divergent pathways suggesting involvement of independent receptors. Elucidation of monocyte lysoPC-specific signaling mechanisms will aid in the development of novel strategies for atherosclerosis prevention, diagnosis, and therapy.

  2. The design of PC/MISI, a PC-based common user interface to remote information storage and retrieval systems. Presentation visuals. M.S. Thesis Final Report, 1 Jul. 1985 - 31 Dec. 1987

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Hall, Philip P.

    1985-01-01

    This Working Paper Series entry represents a collection of presentation visuals associated with the companion report entitled, The Design of PC/MISI, a PC-Based Common User Interface to Remote Information Storage and Retrieval Systems, USL/DBMS NASA/RECON Working Paper Series report number DBMS.NASA/RECON-15. The paper discusses the following: problem definition; the PC solution; the goals of system design; the design description; future considerations, the research environment; conclusions.

  3. Off-Center Rotation of CuPc Molecular Rotor on a Bi(111) Surface and the Chiral Feature.

    Science.gov (United States)

    Sun, Kai; Tao, Min-Long; Tu, Yu-Bing; Wang, Jun-Zhong

    2017-05-04

    Molecular rotors with an off-center axis and the chiral feature of achiral CuPc molecules on a semi-metallic Bi(111) surface have been investigated by means of a scanning tunneling microscopy (STM) at liquid nitrogen (LN₂) temperature. The rotation axis of each CuPc molecular rotor is located at the end of a phthalocyanine group. As molecular coverage increases, the CuPc molecules are self-assembled into various nanoclusters and finally into two-dimensional (2D) domains, in which each CuPc molecule exhibits an apparent chiral feature. Such chiral features of the CuPc molecules can be attributed to the combined effect of asymmetric charge transfer between the CuPc and Bi(111) substrate, and the intermolecular van der Waals interactions.

  4. Computation of USGS Soil UHS and Comparison to NEHRP and PC 1 Seismic Response; FINAL

    International Nuclear Information System (INIS)

    Lee, R.C.

    2000-01-01

    Recently, new site-specific seismic design response spectra were developed for Savannah River Site (SRS) performance category (PC) 1,2,3 and 4 structures, systems and components (SSCs) (WSRC, 1997, 1998) in accordance with DOE Standards. The lower performance categories (PC1 and PC2) site-specific design basis were not compatible with the response spectrum generated if building code guidelines were used (National Earthquake Hazard Reduction Program Recommended Provisions for Seismic Regulations for New Building, (NEHRP), 1997). These differences in criteria and approach should be documented and understood. Thus, Westinghouse Savannah River Company (WSRC) initiated this study to evaluate the difference between the building code hazard assessment (NEHRP) and the site-specific hazard evaluations used for SRS design

  5. Ballooning-mirror instability and internally driven Pc 4--5 wave events

    International Nuclear Information System (INIS)

    Cheng, C.Z.; Qian, Q.; Takahashi, K.; Lui, A.T.Y.

    1994-03-01

    A kinetic-MHD field-aligned eigenmode stability analysis of low frequency ballooning-mirror instabilities has been performed for anisotropic pressure plasma sin the magnetosphere. The ballooning mode is mainly a transverse wave driven unstable by pressure gradient in the bad curvature region. The mirror mode with a dominant compressional magnetic field perturbation is excited when the product of plasma beta and pressure anisotropy (P perpendicular /P parallel > 1) is large. From the AMPTE/CCE particle and magnetic field data observed during Pc 4--5 wave events the authors compute the ballooning-mirror instability parameters and perform a correlation study with the theoretical instability threshold. They find that compressional Pc 5 waves approximately satisfy the ballooning-mirror instability condition, and transverse Pc 4--5 waves are probably related to resonant ballooning instabilities with small pressure anisotropy

  6. Proteomic analysis of PC12 cell differentiation induced by ionizing radiation

    International Nuclear Information System (INIS)

    Zhang Junquan; Gao Ronglian; Chen Xiaohua; Wang Zhidong; Dong Bo; Rao Yalan; Hou Lili; Zhang Hao; Mao Bingzhi

    2005-01-01

    Objective: To explore the molecular mechanism of PC12 cell differentiation induced by ionizing radiation and screen the molecular target of nervous system injured by irradiation. Methods: PC12 cells were irradiated with 16 Gy 60 Co γ ray. Total proteins of normal and irradiated cells were prepared 48 hours after irradiation and separated with two dimensional gel electrophoresis. Some differential expressed proteins were characterized with mass spectrometry. Results: 876 differential expressed proteins were observed. Up-regulated expression of ubiquitin carboxyl-terminal hydratase L1 was found. Down-regulated expression of new protein similar to HP1α was found. Conclusion: The characterization of some differential expressed proteins through proteomic analysis would benefit the research of molecular mechanism of PC12 cell differentiation induced by ionizing radiation. (authors)

  7. Unibert - PC software for radiometric level gauging - the LB440 measuring system

    International Nuclear Information System (INIS)

    Mann, H.; Bickert, M.

    2001-01-01

    In almost all industrial branches radiometric measuring systems are being used today for a lot of different tasks. The most common field of this application are level gauging measurements by use of gamma radiation, i.e. for level detection as well as for level gauging over ranges of up to several meters. For our level gauge measuring system LB440 we developed a clearly arranged PC software, which allows starting, measuring and service of the level gauge. Over the RS232-interface the industrial computer can be connected with a Laptop or PC. The software is a supplemental or even a substitute for the operation over the frontpanel. The measuring system can be completely controlled by the Unibert PC-Software, realised by LabVIEW 5.1.1, which offers an interactive graphical user interface. The same functionality as in the ''embedded - software'' is available, completed with some additional functions. (orig.) [de

  8. Trending in Pc Measurements via a Bayesian Zero-Inflated Mixed Model

    Science.gov (United States)

    Vallejo, Jonathon; Hejduk, Matthew; Stamey, James

    2015-01-01

    Two satellites predicted to come within close proximity of one another, usually a high-value satellite and a piece of space debris moving the active satellite is a means of reducing collision risk but reduces satellite lifetime, perturbs satellite mission, and introduces its own risks. So important to get a good statement of the risk of collision in order to determine whether a maneuver is truly necessary. Two aspects of this Calculation of the Probability of Collision (Pc) based on the most recent set of position velocity and uncertainty data for both satellites. Examination of the changes in the Pc value as the event develops. Events should follow a canonical development (Pc vs time to closest approach (TCA)). Helpful to be able to guess where the present data point fits in the canonical development in order to guide operational response.

  9. Digital video timing analyzer for the evaluation of PC-based real-time simulation systems

    Science.gov (United States)

    Jones, Shawn R.; Crosby, Jay L.; Terry, John E., Jr.

    2009-05-01

    Due to the rapid acceleration in technology and the drop in costs, the use of commercial off-the-shelf (COTS) PC-based hardware and software components for digital and hardware-in-the-loop (HWIL) simulations has increased. However, the increase in PC-based components creates new challenges for HWIL test facilities such as cost-effective hardware and software selection, system configuration and integration, performance testing, and simulation verification/validation. This paper will discuss how the Digital Video Timing Analyzer (DiViTA) installed in the Aviation and Missile Research, Development and Engineering Center (AMRDEC) provides quantitative characterization data for PC-based real-time scene generation systems. An overview of the DiViTA is provided followed by details on measurement techniques, applications, and real-world examples of system benefits.

  10. The use of PC based VR in clinical medicine: the VREPAR projects.

    Science.gov (United States)

    Riva, G; Bacchetta, M; Baruffi, M; Borgomainerio, E; Defrance, C; Gatti, F; Galimberti, C; Fontaneto, S; Marchi, S; Molinari, E; Nugues, P; Rinaldi, S; Rovetta, A; Ferretti, G S; Tonci, A; Wann, J; Vincelli, F

    1999-01-01

    Virtual reality (VR) is an emerging technology that alters the way individuals interact with computers: a 3D computer-generated environment in which a person can move about and interact as if he actually was inside it. Given to the high computational power required to create virtual environments, these are usually developed on expensive high-end workstations. However, the significant advances in PC hardware that have been made over the last three years, are making PC-based VR a possible solution for clinical assessment and therapy. VREPAR - Virtual Reality Environments for Psychoneurophysiological Assessment and Rehabilitation - are two European Community funded projects (Telematics for health - HC 1053/HC 1055 - http://www.psicologia.net) that are trying to develop a modular PC-based virtual reality system for the medical market. The paper describes the rationale of the developed modules and the preliminary results obtained.

  11. Design of multichannel counting system-2 for IBM PC and compatibles

    International Nuclear Information System (INIS)

    Ahmad, Z.; Qamer, R.; Mushtaq, N.

    2001-04-01

    A multichannel, Counting System 2 (MCCS-2) data acquisition plug-in card for the IBM ISA, MCA and EISA bus architecture has been designed and developed for acquisition of pulsed signal. The card features large dynamic range is achieved with the help of 16-bit pulse counters, fast signal acquisition and a self-testing capability in a single slot card. The MCCS-2 (designed by R and D group, CD) is an upgraded version of MCCS-1 [6]. The MCCS-2 consists of a plug-in interface card (MCCS-PC) for IBM PC and compatibles and a BNC terminal module (MCCS-BNC). The MCCS-PC is address selectable and can simultaneous monitoring ten independent SCA inputs. An on board programmable timer provides elapsed time measurement. A menu-driven software program is developed for data acquisition and timer control. (author)

  12. Photoconductive properties of organic-inorganic Ag/p-CuPc/n-GaAs/Ag cell

    Energy Technology Data Exchange (ETDEWEB)

    Karimov, Khasan Sanginovich; Saeed, Muhammad Tariq; Khalid, Fazal Ahmad [GIK Institute of Engineering Sciences and Technology, Top 23640, Swabi, Khyber Pakhtunkhwa (Pakistan); Karieva, Zioda Mirzoevna, E-mail: tariqchani@hotmail.com [Tajik Technical University, Rajabov St.10, Dushanbe, 734000 (Tajikistan)

    2011-07-15

    A thin film of copper phthalocyanine (CuPc), a p-type semiconductor, was deposited by thermal evaporation in vacuum on an n-type gallium arsenide (GaAs) single-crystal semiconductor substrate. Then semi-transparent Ag thin film was deposited onto the CuPc film also by thermal evaporation to fabricate the Ag/p-CuPc/n-GaAs/Ag cell. Photoconduction of the cell was measured in photoresistive and photodiode modes of operation. It was observed that with an increase in illumination, the photoresistance decreased in reverse bias while it increased in forward bias. The photocurrent was increased in reverse bias operation. In forward bias operation with an increase in illumination, the photocurrent showed a different behavior depending on the voltage applied. (semiconductor physics)

  13. Novel Mutations in the PC Gene in Patients with Type B Pyruvate Carboxylase Deficiency

    DEFF Research Database (Denmark)

    Ostergaard, Elsebet; Duno, Morten; Møller, Lisbeth Birk

    2013-01-01

    We have investigated seven patients with the type B form of pyruvate carboxylase (PC) deficiency. Mutation analysis revealed eight mutations, all novel. In a patient with exon skipping on cDNA analysis, we identified a homozygous mutation located in a potential branch point sequence, the first...... possible branch point mutation in PC. Two patients were homozygous for missense mutations (with normal protein amounts on western blot analysis), and two patients were homozygous for nonsense mutations. In addition, a duplication of one base pair was found in a patient who also harboured a splice site...... mutation. Another splice site mutation led to the activation of a cryptic splice site, shown by cDNA analysis.All patients reported until now with at least one missense mutation have had the milder type A form of PC deficiency. We thus report for the first time two patients with homozygous missense...

  14. Desain dan Implementasi Sistem Kendali CNC Router Menggunakan PC untuk Flame Cutting Machine

    Directory of Open Access Journals (Sweden)

    Roni Permana Saputra

    2012-03-01

    Full Text Available This paper focuses on design of router control systems based on computer numerical control (CNC using personal computer (PC implemented in flame cutting machine (FCM. NC-Code entered into the computer translated to be a command signal sent by the PC to a microcontroller to control the end effector’s movement alongthe X and Y axis simultaneously based on linear and circular interpolations calculation on the PC. This control system is implemented on FCM by connecting the output control of the microcontroller with the driver actuator of the FCM in the form of a DC motor. The obtained result is in the form of a CNC router control system prototype to be implemented in the FCM which is capable to perform linear interpolation and circular interpolation. 

  15. Empirical modeling of solvent extraction of uranium from sulphuric acid medium using PC-88A and TOPO as extractants

    International Nuclear Information System (INIS)

    Biswas, S.; Roy, S.B.; Pathak, P.N.; Manchanda, V.K.; Singh, D.K.

    2011-01-01

    Extraction behavior of uranium (VI) from sulphuric acid medium using PC-88A (H 2 A 2 , dimer form) and a mixture of PC-88A + TOPO in n-dodecane has been investigated. The extraction data have been used to develop a mathematical model correlating percentage extraction (%E) with PC-88A and TOPO concentration. It can be used to predict the steady-state concentrations of metal ion under the conditions of the present work. (author)

  16. Diagnostic Accuracy of the Primary Care Screener for Affective Disorder (PC-SAD) in Primary Care.

    Science.gov (United States)

    Picardi, Angelo; Adler, D A; Rogers, W H; Lega, I; Zerella, M P; Matteucci, G; Tarsitani, L; Caredda, M; Gigantesco, A; Biondi, M

    2013-01-01

    Depression goes often unrecognised and untreated in non-psychiatric medical settings. Screening has recently gained acceptance as a first step towards improving depression recognition and management. The Primary Care Screener for Affective Disorders (PC-SAD) is a self-administered questionnaire to screen for Major Depressive Disorder (MDD) and Dysthymic Disorder (Dys) which has a sophisticated scoring algorithm that confers several advantages. This study tested its performance against a 'gold standard' diagnostic interview in primary care. A total of 416 adults attending 13 urban general internal medicine primary care practices completed the PC-SAD. Of 409 who returned a valid PC-SAD, all those scoring positive (N=151) and a random sample (N=106) of those scoring negative were selected for a 3-month telephone follow-up assessment including the administration of the Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID-I) by a psychiatrist who was masked to PC-SAD results. Most selected patients (N=212) took part in the follow-up assessment. After adjustment for partial verification bias the sensitivity, specificity, positive and negative predictive value for MDD were 90%, 83%, 51%, and 98%. For Dys, the corresponding figures were 78%, 79%, 8%, and 88%. While some study limitations suggest caution in interpreting our results, this study corroborated the diagnostic validity of the PC-SAD, although the low PPV may limit its usefulness with regard to Dys. Given its good psychometric properties and the short average administration time, the PC-SAD might be the screening instrument of choice in settings where the technology for computer automated scoring is available.

  17. In situ corrosion monitoring of PC structures with distributed hybrid carbon fiber reinforced polymer sensors

    Science.gov (United States)

    Yang, C. Q.; Wu, Z. S.

    2007-08-01

    Firstly, the fabrication and sensing properties of hybrid carbon fiber reinforced polymer (HCFRP) composite sensors are addressed. In order to provide a distributed sensing manner, the HCFRP sensors were divided into multi-zones with electrodes, and each zone was regarded as a separate sensor. Secondly, their application is studied to monitor the steel corrosion of prestressed concrete (PC) beams. The HCFRP sensors with different gauge lengths were mounted on a PC tendon, steel bar and embedded in tensile and compressive sides of the PC beam. The experiment was carried out under an electric accelerated corrosion and a constant load of about 54 kN. The results reveal that the corrosion of the PC tendon can be monitored through measuring the electrical resistance (ER) change of the HCFRP sensors. For the sensors embedded in tensile side of the PC beam, their ER increases as the corrosion progresses, whereas for the sensors embedded in compressive side, their ER decreases with corrosion time. Moreover, the strains due to the corrosion can be obtained based on the ER change and calibration curves of HCFRP sensors. The strains measured with traditional strain gauges agree with the strains calculated from the ER changes of HCFRP sensors. The electrical behavior of the zones where the corrosion was performed is much different from those of the other zones. In these zones, either there exist jumps in ER, or the ER increases with a much larger rate than those of the other zones. Distributed corrosion monitoring for PC structures is thus demonstrated with the application of HCFRP sensors through a proper installation of multi-electrodes.

  18. DA-9801 promotes neurite outgrowth via ERK1/2-CREB pathway in PC12 cells.

    Science.gov (United States)

    Won, Jong Hoon; Ahn, Kyong Hoon; Back, Moon Jung; Ha, Hae Chan; Jang, Ji Min; Kim, Ha Hyung; Choi, Sang-Zin; Son, Miwon; Kim, Dae Kyong

    2015-01-01

    In the present study, we examined the mechanisms underlying the effect of DA-9801 on neurite outgrowth. We found that DA-9801 elicits its effects via the mitogen-activated protein kinase (MEK) extracellular signal-regulated kinase (ERK)1/2-cAMP response element-binding protein (CREB) pathway. DA-9801, an extract from a mixture of Dioscorea japonica and Dioscorea nipponica, was reported to promote neurite outgrowth in PC12 cells. The effects of DA-9801 on cell viability and expression of neuronal markers were evaluated in PC12 cells. To investigate DA-9801 action, specific inhibitors targeting the ERK signaling cascade were used. No cytotoxicity was observed in PC12 cells at DA-9801 concentrations of less than 30 µg/mL. In the presence of nerve growth factor (NGF, 2 ng/mL), DA-9801 promoted neurite outgrowth and increased the relative mRNA levels of neurofilament-L (NF-L), a marker of neuronal differentiation. The Raf-1 inhibitor GW5074 and MEK inhibitor PD98059 significantly attenuated DA-9801-induced neurite outgrowth. Additionally, the MEK1 and MEK2 inhibitor SL327 significantly attenuated the increase in the percentage of neurite-bearing PC12 cells induced by DA-9801 treatment. Conversely, the selective p38 mitogen-activated protein kinase inhibitor SB203580 did not attenuate the DA-9801 treatment-induced increase in the percentage of neurite-bearing PC12 cells. DA-9801 enhanced the phosphorylation of ERK1/2 and CREB in PC12 cells incubated with and without NGF. Pretreatment with PD98059 blocked the DA-9801-induced phosphorylation of ERK1/2 and CREB. In conclusion, DA-9801 induces neurite outgrowth by affecting the ERK1/2-CREB signaling pathway. Insights into the mechanism underlying this effect of DA-9801 may suggest novel potential strategies for the treatment of peripheral neuropathy.

  19. Cytoprotective effects of fisetin against hypoxia-induced cell death in PC12 cells.

    Science.gov (United States)

    Chen, Pei-Yi; Ho, Yi-Ru; Wu, Ming-Jiuan; Huang, Shun-Ping; Chen, Po-Kong; Tai, Mi-Hsueh; Ho, Chi-Tang; Yen, Jui-Hung

    2015-01-01

    Fisetin (3,7,3',4'-tetrahydroxyflavone), a flavonol compound of flavonoids, exhibits a broad spectrum of biological activities including anti-oxidant, anti-inflammatory, anti-cancer and neuroprotective effects. The aim of this study is to investigate the cytoprotective effect of fisetin and the underlying molecular mechanism against hypoxia-induced cell death in PC12 cells. The results of this study showed that fisetin significantly restored the cell viability of PC12 cells under both cobalt chloride (CoCl₂)- and low oxygen-induced hypoxic conditions. Treatment with fisetin successfully reduced the CoCl₂-mediated reactive oxygen species (ROS) production, which was accompanied by an increase in the cell viability of PC12 cells. Furthermore, we found that treatment of PC12 cells with fisetin markedly upregulated hypoxia-inducible factor 1α (HIF-1α), its nuclear accumulation and the hypoxia-response element (HRE)-driven transcriptional activation. The fisetin-mediated cytoprotection during CoCl₂ exposure was significantly attenuated through the administration of HIF-1α siRNA. Moreover, we demonstrated that MAPK/ERK kinase 1/2 (MEK1/2), p38 MAPK and phosphatidylinositol 3-kinase (PI3 K) inhibitors significantly blocked the increase in cell survival that was induced by fisetin treatment under hypoxic conditions. Consistently, increased phosphorylation of ERK, p38 and Akt proteins was observed in PC12 cells treated with fisetin. However, the fisetin-induced HRE-driven transcription was not affected by inhibition of these kinase signaling pathways. Current results reveal for the first time that fisetin promotes cell survival and protects against hypoxia-induced cell death through ROS scavenging and the activation of HIF1α-, MAPK/ERK-, p38 MAPK- and PI3 K/Akt-dependent signaling pathways in PC12 cells.

  20. On the robustness of EC-PC spike detection method for online neural recording.

    Science.gov (United States)

    Zhou, Yin; Wu, Tong; Rastegarnia, Amir; Guan, Cuntai; Keefer, Edward; Yang, Zhi

    2014-09-30

    Online spike detection is an important step to compress neural data and perform real-time neural information decoding. An unsupervised, automatic, yet robust signal processing is strongly desired, thus it can support a wide range of applications. We have developed a novel spike detection algorithm called "exponential component-polynomial component" (EC-PC) spike detection. We firstly evaluate the robustness of the EC-PC spike detector under different firing rates and SNRs. Secondly, we show that the detection Precision can be quantitatively derived without requiring additional user input parameters. We have realized the algorithm (including training) into a 0.13 μm CMOS chip, where an unsupervised, nonparametric operation has been demonstrated. Both simulated data and real data are used to evaluate the method under different firing rates (FRs), SNRs. The results show that the EC-PC spike detector is the most robust in comparison with some popular detectors. Moreover, the EC-PC detector can track changes in the background noise due to the ability to re-estimate the neural data distribution. Both real and synthesized data have been used for testing the proposed algorithm in comparison with other methods, including the absolute thresholding detector (AT), median absolute deviation detector (MAD), nonlinear energy operator detector (NEO), and continuous wavelet detector (CWD). Comparative testing results reveals that the EP-PC detection algorithm performs better than the other algorithms regardless of recording conditions. The EC-PC spike detector can be considered as an unsupervised and robust online spike detection. It is also suitable for hardware implementation. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Opposite Roles of Furin and PC5A in N-Cadherin Processing

    Directory of Open Access Journals (Sweden)

    Deborah Maret

    2012-10-01

    Full Text Available We recently demonstrated that lack of Furin-processing of the N-cadherin precursor (proNCAD in highly invasive melanoma and brain tumor cells results in the cell-surface expression of a nonadhesive protein favoring cell migration and invasion in vitro. Quantitative polymerase chain reaction analysis of malignant human brain tumor cells revealed that of all proprotein convertases (PCs only the levels of Furin and PC5A are modulated, being inversely (Furin or directly (PC5A correlated with brain tumor invasive capacity. Intriguingly, the N-terminal sequence following the Furin-activated NCAD site (RQKR↓DW161, mouse nomenclature reveals a second putative PC-processing site (RIRSDR↓DK189 located in the first extracellular domain. Cleavage at this site would abolish the adhesive functions of NCAD because of the loss of the critical Trp161. This was confirmed upon analysis of the fate of the endogenous prosegment of proNCAD in human malignant glioma cells expressing high levels of Furin and low levels of PC5A (U343 or high levels of PC5A and negligible Furin levels (U251. Cellular analyses revealed that Furin is the best activating convertase releasing an ∼17-kDa prosegment, whereas PC5A is the major inactivating enzyme resulting in the secretion of an ∼20-kDa product. Like expression of proNCAD at the cell surface, cleavage of the NCAD molecule at RIRSDR↓DK189 renders the U251 cancer cells less adhesive to one another and more migratory. Our work modifies the present view on posttranslational processing and surface expression of classic cadherins and clarifies how NCAD possesses a range of adhesive potentials and plays a critical role in tumor progression.

  2. The USL NASA PC R and D project: Detailed specifications of objects

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Chum, Frank Y.; Hall, Philip P.; Moreau, Dennis R.; Triantafyllopoulos, Spiros

    1984-01-01

    The specifications for a number of projects which are to be implemented within the University of Southwestern Louisiana NASA PC R and D Project are discussed. The goals and objectives of the PC development project and the interrelationships of the various components are discussed. Six projects are described. They are a NASA/RECON simulator, a user interface to multiple remote information systems, evaluation of various personal computer systems, statistical analysis software development, interactive presentation system development, and the development of a distributed processing environment. The relationships of these projects to one another and to the goals and objectives of the overall project are discussed.

  3. PC-based support programs coupled with the sets code for large fault tree analysis

    International Nuclear Information System (INIS)

    Hioki, K.; Nakai, R.

    1989-01-01

    Power Reactor and Nuclear Fuel Development Corporation (PNC) has developed four PC programs: IEIQ (Initiating Event Identification and Quantification), MODESTY (Modular Even Description for a Variety of Systems), FAUST (Fault Summary Tables Generation Program) and ETAAS (Event Tree Analysis Assistant System). These programs prepare the input data for the SETS (Set Equation Transformation System) code and construct and quantify event trees (E/Ts) using the output of the SETS code. The capability of these programs is described and some examples of the results are presented in this paper. With these PC programs and the SETS code, PSA can now be performed with more consistency and less manpower

  4. PC-based input/output controllers from a VME perspective

    International Nuclear Information System (INIS)

    Hill, J.O.

    1999-01-01

    The Experimental Physics and Industrial Control System (EPICS) has been widely adopted in the accelerator community. Although EPICS is available on many platforms, the majority of sites have deployed VME- or VXI-based input output controllers running the vxWorks real time operating system. Recently, a hybrid approach using vxWorks on both PC and traditional platforms is being implemented at LANL. To illustrate these developments the author compares his recent experience deploying PC-based EPICS input output controllers with experience deploying similar systems based on traditional EPICS platforms

  5. Embedded SoPC Design with Nios II Processor and Verilog Examples

    CERN Document Server

    Chu, Pong P

    2012-01-01

    Explores the unique hardware programmability of FPGA-based embedded systems, using a learn-by-doing approach to introduce the concepts and techniques for embedded SoPC design with Verilog An SoPC (system on a programmable chip) integrates a processor, memory modules, I/O peripherals, and custom hardware accelerators into a single FPGA (field-programmable gate array) device. In addition to the customized software, customized hardware can be developed and incorporated into the embedded system as well-allowing us to configure the soft-core processor, create tailored I/O interfaces, and develop s

  6. A Solution-Based Temperature Sensor Using the Organic Compound CuTsPc

    Directory of Open Access Journals (Sweden)

    Shahino Mah Abdullah

    2014-06-01

    Full Text Available An electrochemical cell using an organic compound, copper (II phthalocyanine-tetrasulfonic acid tetrasodium salt (CuTsPc, has been fabricated and investigated as a solution-based temperature sensor. The capacitance and resistance of the ITO/CuTsPc solution/ITO chemical cell has been characterized as a function of temperature in the temperature range of 25–80 °C. A linear response with minimal hysteresis is observed. The fabricated temperature sensor has shown high consistency and sensitive response towards a specific range of temperature values.

  7. Local time asymmetry of Pc 4--5 pulsations and associated particle modulations at synchronous orbit

    International Nuclear Information System (INIS)

    Kokubun, S.; Erickson, K.N.; Fritz, T.A.; McPherron, R.L.

    1989-01-01

    Magnetic field and particle flux observations on board ATS 6 at synchronous altitude are used to examine the dawn-dusk asymmetry of characteristics of Pc 4--5 waves and associated particle flux modulation. Most waves at synchronous orbit having ground correlations are polarized in the azimuthal direction (A class) and are usually detected in the dawn sector. Waves with a radially oriented polarization ellipse (R-class) are almost never observed near the subsatellite point on the ground, except for the regular pulsations known as giant pulsation Pg, observed in the early morning. R class Pc 4 waves occur at all local times and have an occurrence peak in the afternoon

  8. Tests of the power PC theory of causal induction with negative contingencies.

    Science.gov (United States)

    Shanks, David R

    2002-01-01

    The power PC theory of causal induction (Cheng, 1997) proposes that causal estimates are based on the power p of a potential cause, where p is the contingency between the cause and effect normalized by the base rate of the effect. Previous tests of this theory have concentrated on generative causes that have positive contingencies with their associated outcomes. Here we empirically test this theory in two experiments using preventive causes that have negative contingencies for their outcomes. Contrary to the power PC theory, the results show that causal judgments vary with contingency across conditions of constant power p. This pattern is consistent, however, with several alternative accounts of causal judgment.

  9. Prediction and correlation of high-pressure gas solubility in polymers with simplified PC-SAFT

    DEFF Research Database (Denmark)

    von Solms, Nicolas; Michelsen, Michael Locht; Kontogeorgis, Georgios

    2005-01-01

    Using simplified PC-SAFT we have modeled gas solubilities at high temperatures and pressures for the gases methane and carbon dioxide in each of the three polymers high-density polyethylene (HDPE), nylon polyamide-11 (PA-11), and poly(vinylidene fluoride) (PVDF). In general the results are satisf......Using simplified PC-SAFT we have modeled gas solubilities at high temperatures and pressures for the gases methane and carbon dioxide in each of the three polymers high-density polyethylene (HDPE), nylon polyamide-11 (PA-11), and poly(vinylidene fluoride) (PVDF). In general the results...

  10. Analysis of the quantum numbers J(PC) of the X(3872) particle.

    Science.gov (United States)

    Abulencia, A; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J-F; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Budroni, S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carillo, S; Carlsmith, D; Carosi, R; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciljak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Cyr, D; Daronco, S; Datta, M; D'Auria, S; Davies, T; D'Onofrio, M; Dagenhart, D; de Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; Dell'Orso, M; Delli Paoli, F; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; DiTuro, P; Dörr, C; Donati, S; Donega, M; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Field, R; Flanagan, G; Foland, A; Forrester, S; Foster, G W; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garcia, J E; Garberson, F; Garfinkel, A F; Gay, C; Gerberich, H; Gerdes, D; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Gimmell, J L; Ginsburg, C; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Griffiths, M; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B-Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ishizawa, Y; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jensen, H; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kovalev, A; Kraan, A C; Kraus, J; Kravchenko, I; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, J; Lee, J; Lee, Y J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P; Lu, R-S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Manca, G; Margaroli, F; Marginean, R; Marino, C; Marino, C P; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Mastrandrea, P; Masubuchi, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyamoto, A; Moed, S; Moggi, N; Mohr, B; Moore, R; Morello, M; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Nachtman, J; Nagano, A; Naganoma, J; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nigmanov, T; Nodulman, L; Norniella, O; Nurse, E; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Osterberg, K; Pagliarone, C; Palencia, E; Papadimitriou, V; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ranjan, N; Rappoccio, S; Reisert, B; Rekovic, V; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Sabik, S; Safonov, A; Sakumoto, W K; Salamanna, G; Saltó, O; Saltzberg, D; Sánchez, C; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyrla, A; Shapiro, M D; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakyan, A; Sjolin, J; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sun, H; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuchiya, R; Tsuno, S; Turini, N; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vallecorsa, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Veramendi, G; Veszpremi, V; Vidal, R; Vila, I; Vilar, R; Vine, T; Vollrath, I; Volobouev, I; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner, J; Wagner, W; Wallny, R; Wang, S M; Warburton, A; Waschke, S; Waters, D; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zhou, J; Zucchelli, S

    2007-03-30

    We present an analysis of angular distributions and correlations of the X(3872) particle in the exclusive decay mode X(3872)-->J/psipi+ pi- with J/psi-->mu+ mu-. We use 780 pb-1 of data from pp[over ] collisions at sqrt[s]=1.96 TeV collected with the CDF II detector at the Fermilab Tevatron. We derive constraints on spin, parity, and charge conjugation parity of the X(3872) particle by comparing measured angular distributions of the decay products with predictions for different J(PC) hypotheses. The assignments J(PC)=1++ and 2-+ are the only ones consistent with the data.

  11. Mechanistic prospective for human PrPC conversion to PrPSc: Molecular dynamic insights

    OpenAIRE

    Nooshin Azari; Mohammad Reza Dayer; Nematollah Razmi; Mohammad Saaid Dayer

    2013-01-01

    PrPC conversion to PrPSc isoform is the main known cause for prion diseases including Crutzfeldt-Jakob, Gerstmann-Sträussler-Sheinker syndrome and fatal familial insomnia in human. The precise mechanism underling this conversion is yet to be well understood. In the present work, using the coordinate file of PrPC (available on the Protein Data Bank) as a starting structure, separate molecular dynamic simulations were carried out at neutral and acidic pH in an explicit water box at 37°C and 1 ...

  12. Vectorial Resilient PC(l) of Order k Boolean Functions from AG-Codes

    Institute of Scientific and Technical Information of China (English)

    Hao CHEN; Liang MA; Jianhua LI

    2011-01-01

    Propagation criteria and resiliency of vectorial Boolean functions are important for cryptographic purpose (see [1- 4, 7, 8, 10, 11, 16]). Kurosawa, Stoh [8] and Carlet [1]gave a construction of Boolean functions satisfying PC(l) of order k from binary linear or nonlinear codes. In this paper, the algebraic-geometric codes over GF(2m) are used to modify the Carlet and Kurosawa-Satoh's construction for giving vectorial resilient Boolean functions satisfying PC(l) of order k criterion. This new construction is compared with previously known results.

  13. Capabilities, limitations and challenges of a simplified PC-SAFT equation of state

    DEFF Research Database (Denmark)

    von Solms, Nicolas; Kouskoumvekaki, Irene; Michelsen, Michael Locht

    2006-01-01

    and physical performance of a modified PC-SAFT equation of state for highly asymmetric and associating mixtures, Ind. Eng. Chem. Res. 42 (2003) 1098.] has been applied to several complex polymer-sol vent systems, including vapor-liquid equilibria, liquid-liquid equilibria and gas solubilities for both single......-solvent and mixed-solvents (ternary) systems. This manuscript briefly reviews previous successful applications of PC-SAFT, illustrates the capabilities of the model and indicates some problems and limitations in specific areas, especially aqueous systems and blends, as well as challenges that need to be addressed...

  14. Electrical characterization of the ITO/NiPc/PEDOT : PSS junction diode

    Energy Technology Data Exchange (ETDEWEB)

    Shah, Mutabar; Sayyad, M H; Karimov, Kh S; Wahab, Fazal, E-mail: mutabar_shah@hotmail.co, E-mail: mutabarshah@gmail.co [Ghulam Ishaq Khan Institute of Engineering Sciences and Technology, Topi, District Swabi, Khyber Pakhtunkhwa 23640 (Pakistan)

    2010-10-13

    This paper reports on the fabrication and characterization of an ITO/NiPc/PEDOT : PSS junction diode. A thin film of nickel phthalocyanine (NiPc) was deposited by the thermal vacuum deposition method on indium tin oxide (ITO) used as a substrate. The current-voltage characteristics of the diode were measured at room temperature under dark condition and showed rectifying behaviour. The values of several electrical parameters such as ideality factor, barrier height, conductivity, and series and shunt resistances were calculated.

  15. PC-based arc ignition and arc length control system for gas tungsten arc welding

    International Nuclear Information System (INIS)

    Liu, Y.; Cook, G.E.; Barnett, R.J.; Springfield, J.F.

    1992-01-01

    In this paper, a PC-based digital control system for gas tungsten arc welding (GTAW) is presented. This system controls the arc ignition process, the arc length, and the process of welding termination. A DT2818 made by Data Translation is used for interface and A/D and D/A conversions. The digital I/O ports of the DT2818 are used for control of wirefeed, shield gas, cooling water, welding power supply, etc. The DT2818 is housed in a PC. The welding signals and status are displayed on the screen for in-process monitoring. A user can control the welding process by the keyboard

  16. Stability of the Gel Electrolyte PAN : EC : PC : LICF3SO3 towards Lithium

    DEFF Research Database (Denmark)

    Perera, Kumudu; Dissanayake, M.A.K.L.; Skaarup, Steen

    2006-01-01

    The stability of the gel electrolyte consisting of polyacrylonitrile (PAN), ethylene carbonate (EC), propylene carbonate (PC) and lithium trifluoromethanesulfonate (LiCF3SO3 – LiTF) towards metallic lithium was investigated using the time evolution of impedance plots. Symmetric cells of the form Li...... / PAN : EC : PC: LiTF / Li were assembled and impedance data were collected at room temperature for one week. A clear indication of growth of a resistive layer could be seen. The electrolyte resistance remained constant. The growth of the passivation layer became constant after first two days...

  17. ISO-PC Version 1.98: User`s guide

    Energy Technology Data Exchange (ETDEWEB)

    Rittmann, P.D.

    1995-05-02

    This document describes how to use Version 1.98 of the shielding program named ISO-PC. Version 1.98 corrects all known errors in ISOSHLD-II. In addition, a few numeric problems have been eliminated. There are three new namelist variables, 25 additional shielding materials, and 5 more energy groups. The two major differences with the original ISOSHLD-II are the removal of RIBD(radioisotope buildup and decay) source generator, and the removal of the non-uniform source distribution parameter, SSV1. This version of ISO-PC works with photon energies from 10 KeV to 10 MeV using 30 energy groups.

  18. Constraining lowermost mantle structure with PcP/P amplitude ratios from large aperture arrays

    Science.gov (United States)

    Ventosa, S.; Romanowicz, B. A.

    2015-12-01

    Observations of weak short-period teleseismic body waves help to resolve lowermost mantle structure at short wavelengths, which is essential for understanding mantle dynamics and the interactions between the mantle and core. Their limited amount and uneven distribution are however major obstacles to solve for volumetric structure of the D" region, topography of the core-mantle boundary (CMB) and D" discontinuity, and the trade-offs among them. While PcP-P differential travel times provide important information, there are trade-offs between velocity structure and core-mantle boundary topography, which PcP/P amplitude ratios can help resolve, as long as lateral variations in attenuation and biases due to focusing are small or can be corrected for. Dense broadband seismic networks help to improve signal-to-noise ratio (SNR) of the target phases and signal-to-interference ratio (SIR) of other mantle phases when the slowness difference is large enough. To improve SIR and SNR of teleseismic PcP data, we have introduced the slant-stacklet transform to define coherent-guided filters able to separate and enhance signals according to their slowness, time of arrival and frequency content. We thus obtain optimal PcP/P amplitude ratios in the least-square sense using two short sliding windows to match the P signal with a candidate PcP signal. This method allows us to dramatically increase the amount of high-quality observations of short-period PcP/P amplitude ratios by allowing for smaller events and wider epicentral distance and depth ranges.We present the results of measurement of PcP/P amplitude ratios, sampling regions around the Pacific using dense arrays in North America and Japan. We observe that short-period P waves traveling through slabs are strongly affected by focusing, in agreement with the bias we have observed and corrected for due to mantle heterogeneities on PcP-P travel time differences. In Central America, this bias is by far the stronger anomaly we observe

  19. PC index as a proxy of the solar wind energy that entered into the magnetosphere: Development of magnetic substorms

    Science.gov (United States)

    Troshichev, O. A.; Podorozhkina, N. A.; Sormakov, D. A.; Janzhura, A. S.

    2014-08-01

    The Polar Cap (PC) index has been approved by the International Association of Geomagnetism and Aeronomy (IAGA XXII Assembly, Merida, Mexico, 2013) as a new index of magnetic activity. The PC index can be considered to be a proxy of the solar wind energy that enters the magnetosphere. This distinguishes PC from AL and Dst indices that are more related to the dissipation of energy through auroral currents or storage of energy in the ring current during magnetic substorms or storms. The association of the PC index with the direct coupling of the solar wind energy into the magnetosphere is based upon analysis of the relationship of PC with parameters in the solar wind, on the one hand, and correlation between the time series of PC and the AL index (substorm development), on the other hand. This paper (the first of a series) provides the results of statistical investigations that demonstrate a strong correlation between the behavior of PC and the development of magnetic substorms. Substorms are classified as isolated and expanded. We found that (1) substorms are preceded by growth in the RS index, (2) sudden substorm expansion onsets are related to "leap" or "reverse" signatures in the PC index which are indicative of a sharp increase in the PC growth rate, (3) substorms start to develop when PC exceeds a threshold level 1.5 ± 0.5 mV/m irrespective of the length of the substorm growth phase, and (4) there is a linear relation between the intensity of substorms and PC for all substorm events.

  20. Overexpression of vascular endothelial growth factor C increases growth and alters the metastatic pattern of orthotopic PC-3 prostate tumors

    International Nuclear Information System (INIS)

    Tuomela, Johanna; Valta, Maija; Seppänen, Jani; Tarkkonen, Kati; Väänänen, H Kalervo; Härkönen, Pirkko

    2009-01-01

    Prostate cancer metastasizes to regional lymph nodes and distant sites but the roles of lymphatic and hematogenous pathways in metastasis are not fully understood. We studied the roles of VEGF-C and VEGFR3 in prostate cancer metastasis by blocking VEGFR3 using intravenous adenovirus-delivered VEGFR3-Ig fusion protein (VEGFR3-Ig) and by ectopic expression of VEGF-C in PC-3 prostate tumors in nude mice. VEGFR3-Ig decreased the density of lymphatic capillaries in orthotopic PC-3 tumors (p < 0.05) and inhibited metastasis to iliac and sacral lymph nodes. In addition, tumor volumes were smaller in the VEGFR3-Ig-treated group compared with the control group (p < 0.05). Transfection of PC-3 cells with the VEGF-C gene led to a high level of 29/31 kD VEGF-C expression in PC-3 cells. The size of orthotopic and subcutaneous PC-3/VEGF-C tumors was significantly greater than that of PC-3/mock tumors (both p < 0.001). Interestingly, while most orthotopic PC-3 and PC-3/mock tumors grown for 4 weeks metastasized to prostate-draining lymph nodes, orthotopic PC-3/VEGF-C tumors primarily metastasized to the lungs. PC-3/VEGF-C tumors showed highly angiogenic morphology with an increased density of blood capillaries compared with PC-3/mock tumors (p < 0.001). The data suggest that even though VEGF-C/VEGFR3 pathway is primarily required for lymphangiogenesis and lymphatic metastasis, an increased level of VEGF-C can also stimulate angiogenesis, which is associated with growth of orthotopic prostate tumors and a switch from a primary pattern of lymph node metastasis to an increased proportion of metastases at distant sites

  1. Effect of 'PC Game Room' use and polycyclic aromatic hydrocarbon exposure on plasma testosterone concentrations in young male Koreans.

    Science.gov (United States)

    Kim, Heon; Kang, Jong-Won; Ku, Seung-Yup; Kim, Seok Hyun; Cho, Soo-Hun; Koong, Sung-Soo; Kim, Yong-Dae; Lee, Chul-Ho

    2005-03-01

    'PC Game Rooms' were first popularized in Korea, although the concept is now becoming popular worldwide. PC Game Rooms provide users with high-performance PC connected to the high-speed internet, and access to computer games. However, PC Game Room users are exposed to various hazardous agents such as cigarette smoke in a confined environment, and thus it is likely that excessive PC Game Room use involves abnormal exposure to polycyclic aromatic hydrocarbons (PAH) as well as being associated with disturbed sleep or circadian rhythm. In this cross-sectional study, the exposure to PAH was evaluated by measuring urinary 1-hydroxypyrene (1-OHP) and 2-naphthol. The correlations between PC Game Room use and PAH exposure and plasma testosterone and LH levels were analysed in 208 young male Koreans. Urinary 1-OHP concentrations increased (P = 0.0001) and plasma testosterone levels decreased (P = 0.0153) significantly with increased duration of PC Game Room use. Correlation analysis showed that plasma testosterone concentrations were significantly negatively correlated with urinary 1-OHP (r = -0.22, P = 0.0012) and 2-naphthol (r = -0.15, P = 0.0308) concentrations. Moreover, these associations persisted after adjusting for other independent variables. However, the duration of PC Game Room use itself was not found to be an independent significant determinant of plasma testosterone level. Rather, PC Game Room use increased PAH exposure, which decreased plasma testosterone level. The younger age group (15-19 years) showed a more prominent decrease in plasma testosterone concentrations with increasing duration of PC Game Room use than the older age group (20-24 years) (r2 = 0.355, P = 0.0301 versus r2 = 0.213, P = 0.0001). These results imply that the excessive use of PC Game Rooms is related to an adverse impact on sex hormonal status in young male Koreans via PAH exposure. This effect was more prominent in the younger age group.

  2. Letter to the editor: The ionospheric response during an interval of Pc5 ULF wave activity

    Directory of Open Access Journals (Sweden)

    M. Lester

    2000-02-01

    Full Text Available A preliminary analysis of Pc5, ULF wave activity observed with the IMAGE magnetometer array and the EISCAT UHF radar in the post midnight sector indicates that such waves can be caused by the modulation of the ionospheric conductivity as well as the wave electric field. An observed Pc5 pulsation is divided into three separate intervals based upon the EISCAT data. In the first and third, the Pc5 waves are observed only in the measured electron density between 90 and 112 km and maxima in the electron density at these altitudes are attributed to pulsed precipitation of electrons with energies up to 40 keV which result in the height integrated Hall conductivity being pulsed between 10 and 50 S. In the second interval, the Pc5 wave is observed in the F-region ion temperature, electron density and electron temperature but not in the D and E region electron densities. The analysis suggests that the wave during this interval is a coupled Alfven and compressional mode.Key words: Ionosphere (electric fields and currents - Magnetospheric physics (magnetosphere-ionosphere interaction; MHD waves and instabilities

  3. A preliminary evaluation of the Scanditronix PC2048-15B brain scanner

    International Nuclear Information System (INIS)

    Holte, S.; Eriksson, L.; Karolinska Sjukhuset, Stockholm; Dahlbom, M.

    1989-01-01

    The PC2048-15B is the brain version of the new generation of Scanditronix positron camera systems. It is based on a detection unit with 16 scintillating crystals mounted on 2 dual photomultiplier tubes. A system description is given and preliminary test results including spatial resolution, sensitivity to true and random coincidences, scatter correction, and count rate linearity are presented. (orig.)

  4. Analysis and applications of a group contribution sPC-SAFT equation of state

    DEFF Research Database (Denmark)

    Tihic, Amra; von Solms, Nicolas; Michelsen, Michael Locht

    2009-01-01

    A group contribution (GC) method for estimating pure compound parameters for the molecular-based perturbed-chain statistical associating fluid theory (PC-SAFT) equation of state (EoS) is proposed in a previous work [A. Tihic, G.M. Kontogeorgis, N. von Solms, M.L Michelsen, L Constantinou. Ind. En...

  5. Development of a radiometer based on an Add-ON card for PC

    International Nuclear Information System (INIS)

    Bolanos, L.; Lopez, B.; Fernandez, J.L.; Laria, J.

    1997-01-01

    The design of an add-on card for PC that enables it to record nuclear pulses provided by two channels is described in this paper. This card carries acts as a pulse discriminator, and according to the software it finds many appliances in radioimmunoassay, nuclear medicine, industry and other fields

  6. USL/DBMS NASA/PC R and D project system design standards

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Moreau, Dennis R.

    1984-01-01

    A set of system design standards intended to assure the completeness and quality of designs developed for PC research and development projects is established. The standards presented address the areas of problem definition, initial design plan, design specification, and re-evaluation.

  7. USL/DBMS NASA/PC R and D project system testing standards

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Kavi, Srinu; Moreau, Dennis R.; Yan, Lin

    1984-01-01

    A set of system testing standards to be used in the development of all C software within the NASA/PC Research and Development Project is established. Testing will be considered in two phases: the program testing phase and the system testing phase. The objective of these standards is to provide guidelines for the planning and conduct of program and software system testing.

  8. Sistema de detección de fallos basado en PC en calderas pirotubulares

    OpenAIRE

    Rivas Pérez, R.; Feliu Batlle, V.; Sotomayor Moriano, J.

    2005-01-01

    Se ofrece un sistema basado en PC para la detección de fallos en calderas pirotubulares. Se presentan los algoritmos que posibilitan la detección rápida de fallos abruptos en esta clase de plantas, los cuales se basan en la detección de cambios en los

  9. PC-SAFT modeling of CO2 solubilities in hydrophobic deep eutectic solvents

    NARCIS (Netherlands)

    Dietz, C.H.J.T.; van Osch, D.J.G.P.; Kroon, M.C.; Sadowski, G.; van Sint Annaland, M.; Gallucci, F.; Zubeir, L.F.; Held, C.

    2017-01-01

    The PC-SAFT 'pseudo-pure' approach was used for the modeling of CO2 solubilities in various hydrophobic deep eutectic solvents (DESs) for the first time. Only liquid density data were used to obtain the segment number, the temperature-independent segment diameter and the dispersion-energy parameter,

  10. Protective effects of red wine flavonols on 4-hydroxynonenal-induced apoptosis in PC12 cells.

    Science.gov (United States)

    Jang, Young Jin; Kang, Nam Joo; Lee, Ki Won; Lee, Hyong Joo

    2009-08-01

    There is accumulating evidence that a moderate consumption of red wine has health benefits, such as the inhibition of neurodegenerative diseases. Although this is generally attributed to resveratrol, the protective mechanisms and the active substance(s) remain unclear. We examined whether and how red wine extract (RWE) and red wine flavonols quercetin and myricetin inhibited 4-hydroxynonenal (HNE)-induced apoptosis of rat pheochromocytoma PC12 cells. RWE attenuated HNE-induced PC12 cell death in a dose-dependent manner. HNE induced cleavage of poly(ADP-ribose) polymerase, which is involved in DNA repair in the nucleus, and this was inhibited by RWE treatment. Treatment with RWE also inhibited HNE-induced nuclear condensation in PC12 cells. Data of 2',7'-dichlorofluorescin diacetate showed that RWE protected against apoptosis of PC12 cells by attenuating intracellular reactive oxygen species. The cytoprotective effects on HNE-induced cell death were stronger for quercetin and myricetin than for resveratrol. HNE-induced nuclear condensation was attenuated by quercetin and myricetin. These results suggest that the neuroprotective potential of red wine is attributable to flavonols rather than to resveratrol.

  11. IBM PC based real time photon correlator [Paper No.:D2

    International Nuclear Information System (INIS)

    Kumaravadivelu, C.; Nageswaran, A.; Weling, S. A.

    1993-01-01

    The design aspects and development of IBM PC based real time photon correlator is presented. This system computes 64 auto-correlation functions in real time. Sample data is 4-bit wide. Correlation functions are computed in hard wired logic using discrete components. A combination of parallel and pipelined architecture is adopted to compute the correlation in realtime. A high speed controller generates the required control signals for the computing hardware and also provides handshake signals to IBM PC to access the computed results. IBM PC bus is extended and interfaced to correlation computing hardware. IBM PC collects the experimental parameters through user friendly menu and initiates the correlation hardware and continues to collect the correlation build ups and displays them on the screen. Extensive test and maintenance features are incorporated into the system. This system is developed for Material Science Division in Indira Gandhi Centre for Atomic Research (IGCAR) to study static and dynamic properties of macro molecules and colloidal particles in dispersion using light scattering technique. It can also be used to study the flow characteristics of sodium in nuclear reactors. It can be used in dynamic neutron scattering experiments. (author). 3 figs., 2 tabs

  12. Spectral structure of Pc3–4 pulsations: possible signatures of cavity modes

    Directory of Open Access Journals (Sweden)

    P. R. Sutcliffe

    2013-04-01

    Full Text Available In this study we investigate the spectral structure of Pc3–4 pulsations observed at low and midlatitudes. For this purpose, ground-based magnetometer data recorded at the MM100 stations in Europe and at two low latitude stations in South Africa were used. In addition, fluxgate magnetometer data from the CHAMP (CHAllenging Minisatellite Payload low Earth orbit satellite were used. The results of our analysis suggest that at least three mechanisms contribute to the spectral content of Pc3–4 pulsations typically observed at these latitudes. We confirm that a typical Pc3–4 pulsation contains a field line resonance (FLR contribution, with latitude dependent frequency, and an upstream wave (UW contribution, with frequency proportional to the IMF (interplanetary magnetic field magnitude BIMF. Besides the FLR and UW contributions, the Pc3–4 pulsations consistently contain signals at other frequencies that are independent of latitude and BIMF. We suggest that the most likely explanation for these additional frequency contributions is that they are fast mode resonances (FMRs related to cavity, waveguide, or virtual modes. Although the above contributions to the pulsation spectral structure have been reported previously, we believe that this is the first time where evidence is presented showing that they are all present simultaneously in both ground-based and satellite data.

  13. Dasatinib inhibits both osteoclast activation and prostate cancer PC-3-cell-induced osteoclast formation.

    Science.gov (United States)

    Araujo, John C; Poblenz, Ann; Corn, Paul; Parikh, Nila U; Starbuck, Michael W; Thompson, Jerry T; Lee, Francis; Logothetis, Christopher J; Darnay, Bryant G

    2009-11-01

    Therapies to target prostate cancer bone metastases have only limited effects. New treatments are focused on the interaction between cancer cells, bone marrow cells and the bone matrix. Osteoclasts play an important role in the development of bone tumors caused by prostate cancer. Since Src kinase has been shown to be necessary for osteoclast function, we hypothesized that dasatinib, a Src family kinase inhibitor, would reduce osteoclast activity and prostate cancer (PC-3) cell-induced osteoclast formation. Dasatinib inhibited RANKL-induced osteoclast differentiation of bone marrow-derived monocytes with an EC(50) of 7.5 nM. PC-3 cells, a human prostate cancer cell line, were able to differentiate RAW 264.7 cells, a murine monocytic cell line, into osteoclasts, and dasatinib inhibited this differentiation. In addition, conditioned medium from PC-3 cell cultures was able to differentiate RAW 264.7 cells into osteoclasts and this too, was inhibited by dasatinib. Even the lowest concentration of dasatinib, 1.25 nmol, inhibited osteoclast differentiation by 29%. Moreover, dasatinib inhibited osteoclast activity by 58% as measured by collagen 1 release. We performed in vitro experiments utilizing the Src family kinase inhibitor dasatinib to target osteoclast activation as a means of inhibiting prostate cancer bone metastases. Dasatinib inhibits osteoclast differentiation of mouse primary bone marrow-derived monocytes and PC-3 cell-induced osteoclast differentiation. Dasatinib also inhibits osteoclast degradation activity. Inhibiting osteoclast differentiation and activity may be an effective targeted therapy in patients with prostate cancer bone metastases.

  14. 75 FR 8473 - Airworthiness Directives; PILATUS AIRCRAFT LTD. Model PC-12/47E Airplanes

    Science.gov (United States)

    2010-02-25

    .... 11 to PC-12/47E Pilot's Operating Handbook, Report No. 02277, dated March 18, 2009, listed in this AD... Docket Management Facility, U.S. Department of Transportation, Docket Operations, M-30, West Building... implemented during production. You may obtain further information by examining the MCAI in the AD docket...

  15. Research of TGF-beta1 Inducing Lung Adencarcinoma PC9 Cells to Mesenchymal Cells Transition

    Directory of Open Access Journals (Sweden)

    Xiaofeng CHEN

    2010-01-01

    Full Text Available Background and objective It has been proven that epithelial-mesenchymal transition (EMT not only correlated with embryonic development but also could promote tumor invasion and metastasis. Transforming growth factor beta-1 (TGF-β1 has been identified as the main inducer of tumor EMT. The aim of this study was to investigate the effects of TGF-β1 on EMT and PI3K/AKT signaling pathway in lung adencarcinoma PC9 cells. Methods Cultured PC9 cells were treated with different concentrations of TGF-β1 for 48 h. The morphological changes were observed under phase-contrast microscopy; EMT relative marker protein changes were assessed by Western blot and immunoflurescence staining. In addition, the expression of AKT and P-AKT were also measured by Western blot. Results The data showed that TGF-β1 could induce PC9 morphological alteration from epithelial to mesenchymal and upregulate the expression of mesenchymal maker protein Fibronectin. Obviously, the expression of P-AKT was downregulated by TGF-β1 treatment for 48 h. Conclusion TGF-β1 might induce EMT of PC9 cells , accompanied by the changes of PI3K/AKT signaling pathway.

  16. Determination of critical epitope of PcMab-47 against human podocalyxin

    Directory of Open Access Journals (Sweden)

    Shunsuke Itai

    2018-07-01

    Full Text Available Podocalyxin (PODXL is a type I transmembrane protein, which is highly glycosylated. PODXL is expressed in some types of human cancer tissues including oral, breast, and lung cancer tissues and may promote tumor growth, invasion, and metastasis. We previously produced PcMab-47, a novel anti-PODXL monoclonal antibody (mAb which reacts with endogenous PODXL-expressing cancer cell lines and normal cells independently of glycosylation in Western blot, flow cytometry, and immunohistochemical analysis. In this study, we used enzyme-linked immunosorbent assay (ELISA, flow cytometry, and immunohistochemical analysis to determine the epitope of PcMab-47. The minimum epitope of PcMab-47 was found to be Asp207, His208, Leu209, and Met210. A blocking peptide containing this minimum epitope completely neutralized PcMab-47 reaction against oral cancer cells by flow cytometry and immunohistochemical analysis. These findings could lead to the production of more functional anti-PODXL mAbs, which are advantageous for antitumor activities.

  17. Determination of critical epitope of PcMab-47 against human podocalyxin.

    Science.gov (United States)

    Itai, Shunsuke; Yamada, Shinji; Kaneko, Mika K; Kato, Yukinari

    2018-07-01

    Podocalyxin (PODXL) is a type I transmembrane protein, which is highly glycosylated. PODXL is expressed in some types of human cancer tissues including oral, breast, and lung cancer tissues and may promote tumor growth, invasion, and metastasis. We previously produced PcMab-47, a novel anti-PODXL monoclonal antibody (mAb) which reacts with endogenous PODXL-expressing cancer cell lines and normal cells independently of glycosylation in Western blot, flow cytometry, and immunohistochemical analysis. In this study, we used enzyme-linked immunosorbent assay (ELISA), flow cytometry, and immunohistochemical analysis to determine the epitope of PcMab-47. The minimum epitope of PcMab-47 was found to be Asp207, His208, Leu209, and Met210. A blocking peptide containing this minimum epitope completely neutralized PcMab-47 reaction against oral cancer cells by flow cytometry and immunohistochemical analysis. These findings could lead to the production of more functional anti-PODXL mAbs, which are advantageous for antitumor activities.

  18. NESSY, a relational PC database for nuclear structure and decay data

    International Nuclear Information System (INIS)

    Boboshin, I.N.; Varlamov, V.V.; Trukhanov, S.K.

    1994-11-01

    The universal relational database NESSY (New ENSDF Search SYstem) based on the international ENSDF system (Evaluated Nuclear Structure Data File) is described. NESSY, which was developed for IBM compatible PC, provides high efficiency processing of ENSDF information for searches and retrievals of nuclear physics data. The principle of the database development and examples of applications are presented. (author)

  19. Curcumin Protects β-Lactoglobulin Fibril Formation and Fibril-Induced Neurotoxicity in PC12 Cells.

    Directory of Open Access Journals (Sweden)

    Mansooreh Mazaheri

    Full Text Available In this study the β-lactoglobulin fibrillation, in the presence or absence of lead ions, aflatoxin M1 and curcumin, was evaluated using ThT fluorescence, Circular dichroism spectroscopy and atomic force microscopy. To investigate the toxicity of the different form of β-Lg fibrils, in the presence or absence of above toxins and curcumin, we monitored changes in the level of reactive oxygen species and morphology of the differentiated neuron-like PC12 cells. The cell viability, cell body area, average neurite length, neurite width, number of primary neurites, percent of bipolar cells and node/primary neurite ratios were used to assess the growth and complexity of PC12 cells exposed to different form of β-Lg fibrils. Incubation of β-Lg with curcumin resulted in a significant decrease in ROS levels even in the presence of lead ions and aflatoxin M1. The β-Lg fibrils formed in the presence of lead ions and aflatoxin M1 attenuated the growth and complexity of PC12 cells compared with other form of β-Lg fibrils. However, the adverse effects of these toxins and protein fibrils were negated in the presence of curcumin. Furthermore, the antioxidant and inhibitory effects of curcumin protected PC12 cells against fibril neurotoxicity and enhanced their survival. Thus, curcumin may provide a protective effect toward β-Lg, and perhaps other protein, fibrils mediated neurotoxicity.

  20. Multi-station basis for Polar Cap (PC) indices: ensuring credibility and operational reliability

    Science.gov (United States)

    Stauning, Peter

    2018-02-01

    The Polar Cap (PC) indices, PCN (North) and PCS (South) are based on polar geomagnetic observations from Qaanaaq (Thule) and Vostok, respectively, processed to measure the transpolar plasma convection that may seriously affect space weather conditions. To establish reliable space weather forecasts based on PC indices, and also to ensure credibility of their use for scientific analyses of solar wind-magnetosphere interactions, additional sources of data for the PC indices are investigated. In the search for alternative index sources, objective quality criteria are established here to be used for the selection among potential candidates. These criteria are applied to existing PC index series to establish a quality scale. In the Canadian region, the data from Resolute Bay magnetometer are shown to provide alternative PCN indices of adequate quality. In Antarctica, the data from Concordia Dome-C observatory are shown to provide basis for alternative PCS indices. In examples to document the usefulness of these alternative index sources it is shown that PCN indices in a real-time version based on magnetometer data from Resolute Bay could have given 6 h of early warning, of which the last 2 h were "red alert", up to the onset of the strong substorm event on 13 March 1989 that caused power outage in Quebec. The alternative PCS indices based on data from Dome-C have helped to disclose that presently available Vostok-based PCS index values are corrupted throughout most of 2011.

  1. Tablet PC: A Preliminary Report on a Tool for Teaching Calculus

    Science.gov (United States)

    Gorgievski, Nicholas; Stroud, Robert; Truxaw, Mary; DeFranco, Thomas

    2005-01-01

    This study examined students' perceptions of the Tablet PC as an instructional tool for teaching Calculus. A thirteen item survey was developed by the researchers and administered to 103 students in an introductory Calculus course at a large university in the Northeast of the United States. The purpose of this survey was to collect data regarding…

  2. PC-based control of the internal target station at the Nuclotron

    Energy Technology Data Exchange (ETDEWEB)

    Kilman, J [and others

    1996-12-31

    A PC-based control system of the internal target at the Nuclotron is described. The system is based on CAMAC-control of the step motor of the station and screen representation of information about needed beam parameters and space-time position of targets relative to a beam. 6 refs.; 4 figs.

  3. K121Q ENPP1/PC-1 gene polymorphism is associated with insulin ...

    Indian Academy of Sciences (India)

    2013-12-04

    Dec 4, 2013 ... ciation of ENPP1/PC-1 K121Q polymorphism with obesity ... vided history of previously diagnosed diabetes or the fasting blood glucose was ≥ 126 ... Mean values of continuous traits were compared using the. Student's t-test ...

  4. Operational Implementation of a Pc Uncertainty Construct for Conjunction Assessment Risk Analysis

    Science.gov (United States)

    Newman, Lauri K.; Hejduk, Matthew D.; Johnson, Lauren C.

    2016-01-01

    Earlier this year the NASA Conjunction Assessment and Risk Analysis (CARA) project presented the theoretical and algorithmic aspects of a method to include the uncertainties in the calculation inputs when computing the probability of collision (Pc) between two space objects, principally uncertainties in the covariances and the hard-body radius. The output of this calculation approach is to produce rather than a single Pc value an entire probability density function that will represent the range of possible Pc values given the uncertainties in the inputs and bring CA risk analysis methodologies more in line with modern risk management theory. The present study provides results from the exercise of this method against an extended dataset of satellite conjunctions in order to determine the effect of its use on the evaluation of conjunction assessment (CA) event risk posture. The effects are found to be considerable: a good number of events are downgraded from or upgraded to a serious risk designation on the basis of consideration of the Pc uncertainty. The findings counsel the integration of the developed methods into NASA CA operations.

  5. Pre-discovery detections and progenitor candidate for SPIRITS17pc in NGC 4388

    Science.gov (United States)

    Jencson, J. E.; Bond, H. E.; Adams, S. M.; Kasliwal, M. M.

    2018-04-01

    We report detections of pre-discovery outbursts of SPIRITS17pc, discovered as part of the ongoing Spitzer InfraRed Intensive Transients Survey (SPIRITS) using the 3.6 and 4.5 micron imaging channels ([3.6] and [4.5]) of the Infrared Array Camera (IRAC) on the Spitzer Space Telescope (ATel #11575).

  6. Bursts of Pc 1-2 related to flux transfer events

    International Nuclear Information System (INIS)

    Arnoldy, R.L.; Cahill, L.J. Jr.; Engebretson, M.J.

    1987-01-01

    Instances of sporadic reconnection of geomagnetic and interplanetary magnetic field lines have been measured by space-craft passing through the dayside magnetopause region (Russell and Elphic 1979; Rijnbeek et al. 1984). The ionospheric signature of the reconnection events (flux transfer events) is a topic of current interest in that if one is evident then ground magnetic field data can be used to monitor the rate of dayside reconnection and conditions under which it occurs in a manner not possible with rapidly moving spacecraft. The proposed ground magnetic signature of a flux transfer event (FTE) is a large amplitude one-cycle Pc 5 (150-600 second period) pulse produced by a large vortex of ionospheric Hall current generated by the field-aligned current in the helical flux tube that has reconnected (Lee 1986). The intent of this article is to provide further data on the possible ground magnetic signatures of FTE (Lanzerotti el al. 1986) as measured by the induction antennas that the University of New Hampshire and the University of Minnesota have operated at high latitudes in the Antarctic and Greenland. With a high-frequency cut-off of 5 hertz, the induction magnetometers can measure Pc 1-2 waves (0.1-5.0 hertz) which cannot be seen by fluxgate instruments. Indeed, Pc 1-2 waves are frequently observed on the ground coincident with the Pc 5 FTE signature which provides some interesting new perspectives on these events

  7. Closing the loop; Production data management by PC's in the field

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, S. (Samedan Oil Corp. (US))

    1991-11-01

    This paper reports that accounting and engineering groups have long commanded a high level of expertise in the ability to manipulate oil well production data for the calculation of well performance trends, reserve estimations, and lease-hold accounting. Unfortunately, the data crucial to the accuracy of this work are often affected negatively by human error in the calculation of production volumes, the time available in performing paperwork-oriented tasks, and the timeliness with which computed data are made available to these groups. To correct this situation, the authors have developed a PC-based Production Acquisition Allocation and Reporting System (PAARS) for field and office personnel. With this system, all data entry and allocations are still assembled in the field, but all calculations are done by the PC. Additional tracked data include personnel costs and activities, regulatory compliance information, and marketing data. Whenever desired, data are transmitted to a central PC or mainframe data base, where they become immediately available for use by accounting, engineering, marketing, and management personnel. At the Offshore Div., for example, the office staff has current production and well test data available off the PC network, for every operated well, when they arrive at work in the morning.

  8. High-latitude Pc 1 bursts arising in the dayside boundary layer region

    International Nuclear Information System (INIS)

    Hansen, H.J.; Fraser, B.J.; Menk, F.W.; Hu, Y.D.; Newell, P.T.; Meng, C.I.; Morris, R.J.

    1992-01-01

    Dayside Pc 1 geomagnetic pulsation bursts have been studied using a three-station array of induction magnetometers located at high latitudes. Associated magnetic variations in the form of solitary pulses often lead the Pc 1 bursts by 1 to 2 min. These pulses are typically associated with riometer absorption events and consequently the precipitation of fluxes of keV electrons. The Pc 1 bursts are interpreted as resulting from ion cyclotron waves which have propagated to the ionosphere from the equatorial boundary layer region. The associated boundary layer ions, identified by the low-altitude DMSP F7 satellite, range between 1 and 5 keV in energy. These particles are considered to be the most likely free energy source for the ion cyclotron waves. It is considered that such resonant ions enter the magnetosphere via the cleft and cusp because this enables a prenoon time of occurrence of most of the observations to be explained. Measured time delays of 40 to 120 s between the associated riometer absorption and Pc 2 bursts are consistent with an ion cyclotron wave generations region located in the equatorial magnetosphere

  9. Free volume changes in mechanically milled PS and PC studied by positron annihilation lifetime spectroscopy (PALS)

    NARCIS (Netherlands)

    Günther-Schade, K.; Castricum, H.L.; Ziegler, H.J.; Bakker, H.; Faupel, F.

    2004-01-01

    The effect of mechanical milling on free volume was studied by means of positron annihilation lifetime spectroscopy (PALS) in polystyrene (PS) as a typical brittle polymer and in polycarbonate (PC) as a tough representative. Long-time milling increases the free volume, while a decrease is observed

  10. Theoretical modeling of the electronic structure and exchange interactions in Cu(II)Pc

    Science.gov (United States)

    Wu, Wei; Fisher, A. J.; Harrison, N. M.; Wang, Hai; Wu, Zhenlin; Gardener, Jules; Heutz, Sandrine; Jones, Tim; Aeppli, Gabriel

    2012-12-01

    We calculate the electronic structure and exchange interactions in a copper(II)phthalocyanine (Cu(II)Pc) crystal as a one-dimensional molecular chain using hybrid exchange density functional theory (DFT). In addition, the intermolecular exchange interactions are also calculated in a molecular dimer using Green's function perturbation theory (GFPT) to illustrate the underlying physics. We find that the exchange interactions depend strongly on the stacking angle, but weakly on the sliding angle (defined in the text). The hybrid DFT calculations also provide an insight into the electronic structure of the Cu(II)Pc molecular chain and demonstrate that on-site electron correlations have a significant effect on the nature of the ground state, the band gap and magnetic excitations. The exchange interactions predicted by our DFT calculations and GFPT calculations agree qualitatively with the recent experimental results on newly found η-Cu(II)Pc and the previous results for the α- and β-phases. This work provides a reliable theoretical basis for the further application of Cu(II)Pc to molecular spintronics and organic-based quantum information processing.

  11. Toluene-induced, Ca2+-dependent vesicular catecholamine release in rat PC12 cells

    NARCIS (Netherlands)

    Westerink, R.H.S.|info:eu-repo/dai/nl/239425952; Vijverberg, H.P.M.|info:eu-repo/dai/nl/068856474

    2002-01-01

    Acute effects of toluene on vesicular catecholamine release from intact PC12 phaeochromocytoma cells have been investigated using carbon fiber microelectrode amperometry. The frequency of vesicles released is low under basal conditions and is enhanced by depolarization. Toluene causes an increase in

  12. User's manual for levelized power generation cost using an IBM PC

    International Nuclear Information System (INIS)

    Fuller, L.C.

    1985-06-01

    Programs for the estimation of levelized electric power generation costs using the BASIC interpreter on an IBM PC are described. Procedures for light-water reactor plants and coal-fired plants include capital investment cost, operation and maintenance cost, fuel cycle cost, nuclear decommissioning cost, and levelized total generation cost

  13. User instructions for levelized power generation cost codes using an IBM-type PC

    International Nuclear Information System (INIS)

    Coen, J.J.; Delene, J.G.

    1989-01-01

    Programs for the calculation of levelized power generation costs using an IBM or compatible PC are described. Cost calculations for nuclear plants and coal-fired plants include capital investment cost, operation and maintenance cost, fuel cycle cost, decommissioning cost, and total levelized power generation cost. 7 refs., 36 figs., 4 tabs

  14. Effects of epigallocatechin gallate on ultra-violet-induced cell death in PC12 cells

    International Nuclear Information System (INIS)

    Takahashi, Hideo; Seki, Sakiko; Sakamoto, Naotaka; Nakagawa, Shigeki

    2002-01-01

    We examined the effects of catechin on ultra-violet-induced cell death in PC12 cells. PC12 cells were irradiated by ultra-violet C (254 nm) (UVC). We found that the lactate dehydrogenase (LDH) activities in culture media and lipid peroxide in PC12 cells, which indicate cell death and cell membrane damage, respectively, were increased by UVC irradiation in a time-dependent manner. Cell death was gradually stimulated for 9 hours of cultivation after a UVC irradiation period of 10 or 30 min. Epigallocatechin gallate (EGCG), which is one of the main catechins found in green tea, suppressed the increase in LDH activity in culture medium and also inhibited the formation of lipid peroxide. IκB, a member of the cell death signaling system, was phosphorylated at 1 hour after 10 min of UVC irradiation. Stimulation of phosphorylation of IκB by UVC was suppressed by the addition of EGCG. We concluded that EGCG protects the PC12 cell from cell damage caused by UVC irradiation. (author)

  15. Ag/PEPC/NiPc/ZnO/Ag thin film capacitive and resistive humidity sensors

    International Nuclear Information System (INIS)

    Karimov, Kh. S.; Saleem, M.; Murtaza, Imran; Farooq, M.; Cheong, Kuan Yew; Noor, Ahmad Fauzi Mohd

    2010-01-01

    A thin film of blended poly-N-epoxypropylcarbazole (PEPC) (25 wt.%), nickel phthalocyanine (NiPc) (50 wt.%) and ZnO nano-powder (25 wt.%) in benzene (5 wt.%) was spin-coated on a glass substrate with silver electrodes to produce a surface-type Ag/PEPC/NiPc/ZnO/Ag capacitive and resistive sensor. Sensors with two different PEPC/NiPc/ZnO film thicknesses (330 and 400 nm) were fabricated and compared. The effects of humidity on capacitance and resistance of the Ag/PEPC/NiPc/ZnO/Ag sensors were investigated at two frequencies of the applied voltage: 120 Hz and 1 kHz. It was observed that at 120 Hz under humidity of up to 95% RH the capacitance of the sensors increased by 540 times and resistance decreased by 450 times with respect to humidity conditions of 50% RH. It was found that the sensor with a thinner semiconducting film (330 nm) was more sensitive than the sensor with a thicker film (400 nm). The sensitivity was improved when the sensor was used at a lower frequency as compared with a high frequency. It is assumed that the humidity response of the sensors is associated with absorption of water vapors and doping of water molecules in the semiconductor blend layer. This had been proven by simulation of the capacitance-humidity relationship. (semiconductor devices)

  16. Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).

    Science.gov (United States)

    Grieben, Mariana; Pike, Ashley C W; Shintre, Chitra A; Venturi, Elisa; El-Ajouz, Sam; Tessitore, Annamaria; Shrestha, Leela; Mukhopadhyay, Shubhashish; Mahajan, Pravin; Chalk, Rod; Burgess-Brown, Nicola A; Sitsapesan, Rebecca; Huiskonen, Juha T; Carpenter, Elisabeth P

    2017-02-01

    Mutations in either polycystin-1 (PC1 or PKD1) or polycystin-2 (PC2, PKD2 or TRPP1) cause autosomal-dominant polycystic kidney disease (ADPKD) through unknown mechanisms. Here we present the structure of human PC2 in a closed conformation, solved by electron cryomicroscopy at 4.2-Å resolution. The structure reveals a novel polycystin-specific 'tetragonal opening for polycystins' (TOP) domain tightly bound to the top of a classic transient receptor potential (TRP) channel structure. The TOP domain is formed from two extensions to the voltage-sensor-like domain (VSLD); it covers the channel's endoplasmic reticulum lumen or extracellular surface and encloses an upper vestibule, above the pore filter, without blocking the ion-conduction pathway. The TOP-domain fold is conserved among the polycystins, including the homologous channel-like region of PC1, and is the site of a cluster of ADPKD-associated missense variants. Extensive contacts among the TOP-domain subunits, the pore and the VSLD provide ample scope for regulation through physical and chemical stimuli.

  17. PC_Eyewitness and the sequential superiority effect: computer-based lineup administration.

    Science.gov (United States)

    MacLin, Otto H; Zimmerman, Laura A; Malpass, Roy S

    2005-06-01

    Computer technology has become an increasingly important tool for conducting eyewitness identifications. In the area of lineup identifications, computerized administration offers several advantages for researchers and law enforcement. PC_Eyewitness is designed specifically to administer lineups. To assess this new lineup technology, two studies were conducted in order to replicate the results of previous studies comparing simultaneous and sequential lineups. One hundred twenty university students participated in each experiment. Experiment 1 used traditional paper-and-pencil lineup administration methods to compare simultaneous to sequential lineups. Experiment 2 used PC_Eyewitness to administer simultaneous and sequential lineups. The results of these studies were compared to the meta-analytic results reported by N. Steblay, J. Dysart, S. Fulero, and R. C. L. Lindsay (2001). No differences were found between paper-and-pencil and PC_Eyewitness lineup administration methods. The core findings of the N. Steblay et al. (2001) meta-analysis were replicated by both administration procedures. These results show that computerized lineup administration using PC_Eyewitness is an effective means for gathering eyewitness identification data.

  18. Influence of flavour absorption on oxygen permentation through LDPE, PP, PC and PET plastics food packaging

    NARCIS (Netherlands)

    Willige, van R.W.G.; Linssen, J.P.H.; Meinders, M.B.J.; Stege, van der H.J.; Voragen, A.G.J.

    2002-01-01

    The effect of flavour absorption on the oxygen permeability of low-density polyethylene (LDPE), polypropylene (PP), polycarbonate (PC) and polyethylene terephthalate (PET) was studied using an isostatic continuous flow system. Polymer samples were exposed to a model solution containing limonene,

  19. Electromagnetic decay widths for L=1, Jsup(PC)=1-- T-baryonia: II

    International Nuclear Information System (INIS)

    Ellis, R.G.; McKellar, B.H.J.; Joshi, G.C.

    1981-01-01

    The electromagnetic decay widths of the Jsup(PC)=1 -- , L=1 T-baryonia in the 1-5 GeV region are estimated. The Van Royen-Weisskopf technique is extended to baryonia within the framework of the QCD potential model. The diquark and antidiquark are assumed to have finite extent. Potential dependent coefficients are scaled from known baryon and mesons

  20. The ENSDF radioactivity data base for IBM-PC and computer network access

    International Nuclear Information System (INIS)

    Ekstroem, P.; Spanier, L.

    1989-08-01

    A database for about 15000 gamma rays from 2777 radioactive nuclides derived from the international Evaluated Nuclear Structure Data File (ENSDF) is described together with supporting computer codes. The database is available on a PC diskette, costfree, from the IAEA Nuclear Data Section. (author)

  1. The ENSDF radioactivity data base for IBM-PC and computer network access

    International Nuclear Information System (INIS)

    Ekstroem, P.; Spanier, L.

    1989-08-01

    A data base system for radioactivity gamma rays is described. A base with approximately 15000 gamma rays from 2777 decays is available for installation on the hard disk of a PC, and a complete system with approximately 73000 gamma rays is available for on-line access via the NORDic University computer NETwork (NORDUNET) and the Swedish University computer NETwork (SUNET)

  2. PcMtr, an aromatic and neutral aliphatic amino acid permease of Penicillium chrysogenum

    NARCIS (Netherlands)

    Trip, H; Evers, ME; Driessen, AJM

    2004-01-01

    The gene encoding an aromatic and neutral aliphatic amino acid permease of Penicillium chrysogenum was cloned, functionally expressed and characterized in Saccharomyces cerevisiae M4276. The permease, designated PcMtr, is structurally and functionally homologous to Mtr of Neurospora crassa, and

  3. Evaluation of thermodynamic properties of fluid mixtures by PC-SAFT model

    International Nuclear Information System (INIS)

    Almasi, Mohammad

    2014-01-01

    Experimental and calculated partial molar volumes (V ¯ m,1 ) of MIK with (♦) 2-PrOH, (♢) 2-BuOH, (●) 2-PenOH at T = 298.15 K. (—) PC-SAFT model. - Highlights: • Densities and viscosities of the mixtures (MIK + 2-alkanols) were measured. • PC-SAFT model was applied to correlate the volumetric properties of binary mixtures. • Agreement between experimental data and calculated values by PC-SAFT model is good. - Abstract: Densities and viscosities of binary mixtures of methyl isobutyl ketone (MIK) with polar solvents namely, 2-propanol, 2-butanol and 2-pentanol, were measured at 7 temperatures (293.15–323.15 K) over the entire range of composition. Using the experimental data, excess molar volumes V m E , isobaric thermal expansivity α p , partial molar volumes V ¯ m,i and viscosity deviations Δη, have been calculated due to their importance in the study of specific molecular interactions. The observed negative and positive values of deviation/excess parameters were explained on the basis of the intermolecular interactions occur in these mixtures. The Perturbed Chain Statistical Association Fluid Theory (PC-SAFT) has been used to correlate the volumetric behavior of the mixtures

  4. Evaluation of thermodynamic properties of fluid mixtures by PC-SAFT model

    Energy Technology Data Exchange (ETDEWEB)

    Almasi, Mohammad, E-mail: m.almasi@khouzestan.srbiau.ac.ir

    2014-09-10

    Experimental and calculated partial molar volumes (V{sup ¯}{sub m,1}) of MIK with (♦) 2-PrOH, (♢) 2-BuOH, (●) 2-PenOH at T = 298.15 K. (—) PC-SAFT model. - Highlights: • Densities and viscosities of the mixtures (MIK + 2-alkanols) were measured. • PC-SAFT model was applied to correlate the volumetric properties of binary mixtures. • Agreement between experimental data and calculated values by PC-SAFT model is good. - Abstract: Densities and viscosities of binary mixtures of methyl isobutyl ketone (MIK) with polar solvents namely, 2-propanol, 2-butanol and 2-pentanol, were measured at 7 temperatures (293.15–323.15 K) over the entire range of composition. Using the experimental data, excess molar volumes V{sub m}{sup E}, isobaric thermal expansivity α{sub p}, partial molar volumes V{sup ¯}{sub m,i} and viscosity deviations Δη, have been calculated due to their importance in the study of specific molecular interactions. The observed negative and positive values of deviation/excess parameters were explained on the basis of the intermolecular interactions occur in these mixtures. The Perturbed Chain Statistical Association Fluid Theory (PC-SAFT) has been used to correlate the volumetric behavior of the mixtures.

  5. Exploring Tablet PC Lectures: Lecturer Experiences and Student Perceptions in Biomedicine

    Science.gov (United States)

    Choate, Julia; Kotsanas, George; Dawson, Phillip

    2014-01-01

    Lecturers using tablet PCs with specialised pens can utilise real-time changes in lecture delivery via digital inking. We investigated student perceptions and lecturer experiences of tablet PC lectures in large-enrolment biomedicine subjects. Lecturers used PowerPoint or Classroom Presenter software for lecture preparation and in-lecture pen-based…

  6. ''Strong gammas''. List of strong gamma-rays emitted from radionuclides. Documentation of the PC diskette

    International Nuclear Information System (INIS)

    Ichimiya, T.; Narita, T.; Kitao, K.

    1994-01-01

    The PC diskette containing the ''List of strong gamma-rays emitted from radionuclides'' as published by T. Narita et al. in the report JAERI-M-94-059, March 1994, is described. The diskette is available from the IAEA Nuclear Data Section, costfree, upon request. (author)

  7. An ME-PC Enhanced HDMR Method for Efficient Statistical Analysis of Multiconductor Transmission Line Networks

    KAUST Repository

    Yucel, Abdulkadir C.

    2015-05-05

    An efficient method for statistically characterizing multiconductor transmission line (MTL) networks subject to a large number of manufacturing uncertainties is presented. The proposed method achieves its efficiency by leveraging a high-dimensional model representation (HDMR) technique that approximates observables (quantities of interest in MTL networks, such as voltages/currents on mission-critical circuits) in terms of iteratively constructed component functions of only the most significant random variables (parameters that characterize the uncertainties in MTL networks, such as conductor locations and widths, and lumped element values). The efficiency of the proposed scheme is further increased using a multielement probabilistic collocation (ME-PC) method to compute the component functions of the HDMR. The ME-PC method makes use of generalized polynomial chaos (gPC) expansions to approximate the component functions, where the expansion coefficients are expressed in terms of integrals of the observable over the random domain. These integrals are numerically evaluated and the observable values at the quadrature/collocation points are computed using a fast deterministic simulator. The proposed method is capable of producing accurate statistical information pertinent to an observable that is rapidly varying across a high-dimensional random domain at a computational cost that is significantly lower than that of gPC or Monte Carlo methods. The applicability, efficiency, and accuracy of the method are demonstrated via statistical characterization of frequency-domain voltages in parallel wire, interconnect, and antenna corporate feed networks.

  8. Study of Polymeric Luminescent Blend (PC/PMMA) Doped with Europium Complex under Gamma-Iradiation

    International Nuclear Information System (INIS)

    Parra, D. F.

    2006-01-01

    Spectroscopic properties of blends formed by bisphenol-A polycarbonate (PC) and poly(methyl methacrylate) (PMMA) doped with europium in organic complex were studied. Polymeric luminescent blends are potential materials for many applications; however, little information has been reported concerning the stability under thermal and radiation conditions. Luminescent films were synthesized from europium thenoyltrifluoroacetonate at different concentrations doped in PC/PMMA blends. Films produced of the luminescent polymer blend were irradiated in a 60 C o source. Their luminescent properties, in the solid state, as well as, the thermal oxidative resistance after gamma irradiation was investigated. These systems were characterized by elemental analysis, thermogravimetry (TGA), differential scanning calorimetry (DSC) and infrared spectroscopy (FTIR). Based on TGA data, the thermal stability of PC/PMMA:(tta)3 system is higher than the polymer blend. The DSC results indicated that those new systems are chemically stables. The emission spectra of the Eu 3 +-tta complex doped in the PC/PMMA recorded at 298 and 77 K exhibited the characteristic bands arising from the 5 D 0 →7 F J transitions (J = 0-6). The luminescence intensity decreases with increasing of precursor concentration in the doped polymer obtained by chemical reaction. This result is different from that of samples obtained by physical method in melting doping. The blend was irradiated under ionizing radiation of 60 C o source. After irradiation of the luminescent films the physical properties of luminescence, thermal and oxidative stability were evaluated.(Fapesp and Cnpq financial support)

  9. Role of Notch-1 signaling in ethanol induced PC12 apoptosis

    African Journals Online (AJOL)

    DR. NJ TONUKARI

    2012-04-17

    Apr 17, 2012 ... Key words: Neuronal PC12 cell, neurodegenerative disease, ethanol, Notch-1. INTRODUCTION. Neurodegenerative disorders (ND) such as Alzheimer's disease (AD) and Parkinson's disease (PD) are pro- gressive, age-dependent neurodegenerative disorder affecting the cortex and hippocampus, and ...

  10. Digitally-controlled PC-interfaced Boost Converter for Educational Purposes

    DEFF Research Database (Denmark)

    Ljusev, Petar; Andersen, Michael A. E.

    2004-01-01

    This paper describes implementation of a simple digital PID control algorithm for a boost converter using a cheap fixed-point 8-bit microcontroller. Serial communication to a PC server program is established for easier downloading of compensator parameters and current and voltage waveform...

  11. The measure and control system of mini-type radon room based on PC104

    International Nuclear Information System (INIS)

    Zhou Shumin; East China Inst. of Technology, Fuzhou; Tang Bin; Sun Yamin

    2005-01-01

    Radon room is one of the standard equipment which demarcates radon measure instrument. The paper discusses the dynamic method and mathematic model which keeps the radon consistence stability in radon room. The system is developed on PC104. The system can monitor the radon consistence and replenishment radon according the radon control parameter. (authors)

  12. Phase Equilibrium Calculations for Multi-Component Polar Fluid Mixtures with tPC-PSAFT

    DEFF Research Database (Denmark)

    Karakatsani, Eirini; Economou, Ioannis

    2007-01-01

    The truncated Perturbed-Chain Polar Statistical Associating Fluid Theory (tPC-PSAFT) is applied to a number of different mixtures, including binary, ternary and quaternary mixtures of components that differ substantially in terms of intermolecular interactions and molecular size. In contrast to m...

  13. Recent Developments in Organophosphorus Flame Retardants Containing P-C Bond and Their Applications

    Directory of Open Access Journals (Sweden)

    Sophie Wendels

    2017-07-01

    Full Text Available Organophosphorus compounds containing P-C bonds are increasingly developed as flame retardant additives due to their excellent thermal and hydrolytic stability and ease of synthesis. The latest development (since 2010 in organophosphorus flame retardants containing P-C bonds summarized in this review. In this review, we have broadly classified such phosphorus compounds based on the carbon unit linked to the phosphorus atom i.e., could be a part of either an aliphatic or an aromatic unit. We have only considered those published literature where a P-C bond was created as a part of synthetic strategy to make either an intermediate or a final organophosphorus compound with an aim to use it as a flame retardant. General synthetic strategies to create P-C bonds are briefly discussed. Most popular synthetic strategies used for developing P-C containing phosphorus based flame retardants include Michael addition, Michaelis–Arbuzov, Friedels–Crafts and Grignard reactions. In general, most flame retardant derivatives discussed in this review have been prepared via a one- to two-step synthetic strategy with relatively high yields greater than 80%. Specific examples of P-C containing flame retardants synthesized via suitable synthetic strategy and their applications on various polymer systems are described in detail. Aliphatic phosphorus compounds being liquids or low melting solids are generally applied in polymers via coatings (cellulose or are incorporated in the bulk of the polymers (epoxy, polyurethanes during their polymerization as reactive or non-reactive additives. Substituents on the P atoms and the chemistry of the polymer matrix greatly influence the flame retardant behavior of these compounds (condensed phase vs. the gas phase. Recently, aromatic DOPO based phosphinate flame retardants have been developed with relatively higher thermal stabilities (>250 °C. Such compounds have potential as flame retardants for high temperature processable

  14. Electrochemistry and spectroelectrochemistry of tert-butylcalix[4]arene bridged bis double-decker lutetium(III) phthalocyanine, Lu2Pc4 and dimeric lutetium(III) phthalocyanine, Lu2Pc2(OAc)2

    International Nuclear Information System (INIS)

    Koca, Atif; Ceyhan, Tanju; Erbil, Mehmet K.; Ozkaya, Ali Riza; Bekaroglu, Ozer

    2007-01-01

    In this study, electrochemical, electrochromic and spectroelectrochemical properties of a tert-butylcalix[4]arene bridged bis double-decker lutetium(III) phthalocyanine (Lu 2 Pc 4 2) were investigated explicitly as compared with a tert-butylcalix[4]arene bridged dimeric lutetium(III) phthalocyanine [Lu 2 Pc 2 (OAc) 2 1]. Distinctive differences between electrochemical and electrochromic properties of 1 and 2 were detected. Moreover, the properties of 1 and 2 were compared with previously reported S 4 (CH 2 ) 4 bridged Lu 2 Pc 2 (OAc) 2 and Lu 2 Pc 4 . The calixarene bridged phthalocyanine (Pc) compounds, 1 and 2 showed well-defined electrochromic behaviour with green-blue and blue-purple colour transitions. The enhanced electrochromic properties of 2, as compared to 1, were attributed to its double-decker structure, probably allowing the formation of suitable ion channels for the counter ion movement in the solid film

  15. Excitons dynamics of 1-chloronaphthalene added P3HT:PC{sub 61}BM solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Xing [Key Laboratory of Luminescence and Optical Information, Beijing Jiaotong University, Ministry of Education, Beijing 100044 (China); Institute of Optoelectronics Technology, Beijing Jiaotong University, Beijing 100044 (China); Zhao, Suling, E-mail: slzhao@bjtu.edu.cn [Key Laboratory of Luminescence and Optical Information, Beijing Jiaotong University, Ministry of Education, Beijing 100044 (China); Institute of Optoelectronics Technology, Beijing Jiaotong University, Beijing 100044 (China); Huang, Qingyu; Yang, Qianqian; Gong, Wei; Xu, Zheng [Key Laboratory of Luminescence and Optical Information, Beijing Jiaotong University, Ministry of Education, Beijing 100044 (China); Institute of Optoelectronics Technology, Beijing Jiaotong University, Beijing 100044 (China)

    2014-08-01

    The charge photogeneration and recombination are comprehensively investigated in blend films based on poly(3-hexylthiophene) (P3HT) as an electron donor and [6,6]-phenyl-C 61-butyric acid methyl ester (PC{sub 61}BM) as an electron accepter. Transient absorption spectroscopy (TAS) together with absorption, photoluminescence (PL) are used respectively to measure optical properties of these blend films. In this paper, we demonstrate that solvent additive 1-chloronaphthalene (CN) has a unique influence on improving the performance of P3HT:PC{sub 61}BM heterojunction solar cell. It is observed that the absorption of additive-added blends has a higher intensity and is red-shifted than that of the P3HT:PC{sub 61}BM blend. The PL intensity increases which suggest that the conjugation length increases or the domain size of P3HT increases. Large domains with serious phase separation influence the interface area between P3HT and PC{sub 61}BM. Excitons are generated in both the P3HT phase and the PC{sub 61}BM phase. In all the film blends with or without additive, strongly bound interfacial CT states are formed by a large fraction of the excitons indicating geminate recombination may occur. It is demonstrated that in the blend with CN added the enhanced fraction of CT states comes from the more crystalline P3HT phases and the slower CT states and mobile charges decay indicates reduced recombination losses from early time recombination. - Highlights: • 1-chloronaphthalene(CN) can enhance the efficiency of P3HT:PCBM Solar Cells from charge photogeneration and recombination. • The enhanced fraction of CT states with CN added comes from the more crystalline P3HT phases and the slower CT states. • Mobile charges decay of blend with CN added indicates reduced recombination losses from early time recombination.

  16. Ninjin'yoeito and ginseng extract prevent oxaliplatin-induced neurodegeneration in PC12 cells.

    Science.gov (United States)

    Suzuki, Toshiaki; Yamamoto, Ayano; Ohsawa, Masahiro; Motoo, Yoshiharu; Mizukami, Hajime; Makino, Toshiaki

    2015-10-01

    Ninjin'yoeito (NYT) is a formula of Japanese traditional kampo medicine composed of 12 crude drugs, and is designed to improve the decline in constitution after recovery from disease, fatigue, anemia, anorexia, perspiration during sleep, cold limbs, slight fever, chills, persistent cough, malaise, mental disequilibrium, insomnia, and constipation. Oxaliplatin (L-OHP) is a platinum-based anticancer drug used to treat colorectal, pancreatic, and stomach cancers. However, it often causes acute and chronic peripheral neuropathies including cold allodynia and mechanical hyperalgesia. In this study, we investigated the preventive effects of NYT on neuronal degeneration caused by L-OHP using PC12 cells, which are derived from the rat adrenal medulla and differentiate into nerve-like cells after exposure to nerve growth factor. L-OHP treatment decreased the elongation of neurite-like projection outgrowths in differentiated PC12 cells. When PC12 cells were treated with NYT hot water extract, neurodegeneration caused by L-OHP was significantly prevented in a concentration-dependent manner. Among the 12 crude drugs composing NYT, the extract of Ginseng (the root of Panax ginseng) exhibited the strongest preventive effects on neurodegeneration in differentiated PC12 cells. By activity-guided fractionation, we found that the fraction containing ginsenosides displayed preventive activity and, among several ginsenosides, ginsenoside F2 exhibited significant preventive effects on L-OHP-induced decreases in neurite-like outgrowths in differentiated PC12 cells. These results suggest that NYT and ginseng are promising agents for preventing L-OHP-induced neuropathies and present ginsenoside F2 as one of the active ingredients in ginseng.

  17. Liver X receptor activation inhibits PC-3 prostate cancer cells via the beta-catenin pathway.

    Science.gov (United States)

    Youlin, Kuang; Li, Zhang; Weiyang, He; Jian, Kang; Siming, Liang; Xin, Gou

    2017-03-01

    Liver X receptors (LXRs) are nuclear receptors family of ligand-dependent transcription factors that play a crucial role in regulating cholesterol metabolism and inflammation. Recent studies show that LXR agonists exhibit anti-cancer activities in a variety of cancer cell lines including prostate. To further identify the potential mechanisms of LXRα activation on prostate cancer, we investigated the effect of LXR agonist T0901317 on PC3 prostate cancer cell and in which activity of beta-catenin pathway involved. Prostate cancer PC3 cells were transfected with LXR-a siRNA and treated with LXR activator T0901317. qRT-PCR and western blot were used to detect the LXR-a expression. beta-catenin, cyclin D1 and c-MYC were analyzed by western blot. Cell apoptosis was examined by flow cytometry and Cell proliferation was assessed by Cell Counting Kit-8 assay. Cell migration was detected by Transwell chambers. Data showed that T0901317 significantly inhibited PC3 cell proliferation as well as invasion and increased apoptosis in vitro. Furthermore, we found that LXRα activation induced the reduction of beta-catenin expression in PC3 cells, and this inhibitory effect could be totally abolished when cells were treated with LXRα. Meanwhile, the expression of beta-catenin target gene cyclin D1 and c-MYC were also decreased. This study provided additional evidence that LXR activation inhibited PC-3 prostate cancer cells via suppressing beta-catenin pathway. Copyright © 2016 Elsevier GmbH. All rights reserved.

  18. AMP-activated kinase mediates adipose stem cell-stimulated neuritogenesis of PC12 cells.

    Science.gov (United States)

    Tan, B; Luan, Z; Wei, X; He, Y; Wei, G; Johnstone, B H; Farlow, M; Du, Y

    2011-05-05

    Adipose tissue stroma contains a population of mesenchymal stem cells, which support repair of damaged tissues through the protective effects of secreted trophic factors. Neurotrophic factors, including nerve growth factor (NGF) have been identified in media collected from cultured adipose-derived stem cells (ASC). We previously demonstrated that administration of cell-free ASC conditioned medium (ASC-CM) at 24 h after injury reduced lesion volume and promoted functional recovery in a rat model of neonatal brain hypoxic-ischemic (HI) injury. The timing of administration well after the peak in neural cell apoptosis in the affected region suggests that regeneration of lost neurons is promoted by factors in ASC-CM. In this study, we determined which of the factors in ASC-CM could induce neurogenesis by testing the ability of the mixture, either whole or after inactivating specific components, to stimulate neurite outgrowth in vitro using the neurogenic cell line PC12. Neuritogenesis in PC12 cells treated with ASC-CM was observed at a level comparable to that observed with purified recombinant NGF. It was observed that NGF in ASC-CM was mainly responsible for inducing PC12 cell neuritogenesis. Interestingly, both ASC-CM and NGF induced PC12 cell neuritogenesis through activation of the AMP-activated kinase (AMPK) pathway which is the central protein involved in controlling many critical functions in response to changes in the cellular energy status. Pharmacological and genetic inhibition of AMPK activity greatly reduced neuritogenesis in PC12 cells. These results suggest that, in addition to possessing neuroprotective properties, ASC-CM mediates repair of damaged tissues through inducing neuronal differentiation via NGF-induced AMPK activation. Copyright © 2011 IBRO. Published by Elsevier Ltd. All rights reserved.

  19. PHYSICAL PROPERTIES OF THE CURRENT CENSUS OF NORTHERN WHITE DWARFS WITHIN 40 pc OF THE SUN

    International Nuclear Information System (INIS)

    Limoges, M.-M.; Bergeron, P.; Lépine, S.

    2015-01-01

    We present a detailed description of the physical properties of our current census of white dwarfs within 40 pc of the Sun, based on an exhaustive spectroscopic survey of northern hemisphere candidates from the SUPERBLINK proper motion database. Our method for selecting white dwarf candidates is based on a combination of theoretical color–magnitude relations and reduced proper motion diagrams. We reported in an earlier publication the discovery of nearly 200 new white dwarfs, and we present here the discovery of an additional 133 new white dwarfs, among which we identify 96 DA, 3 DB, 24 DC, 3 DQ, and 7 DZ stars. We further identify 178 white dwarfs that lie within 40 pc of the Sun, representing a 40% increase of the current census, which now includes 492 objects. We estimate the completeness of our survey at between 66% and 78%, allowing for uncertainties in the distance estimates. We also perform a homogeneous model atmosphere analysis of this 40 pc sample and find a large fraction of massive white dwarfs, indicating that we are successfully recovering the more massive, and less luminous objects often missed in other surveys. We also show that the 40 pc sample is dominated by cool and old white dwarfs, which populate the faint end of the luminosity function, although trigonometric parallaxes will be needed to shape this part of the luminosity function more accurately. Finally, we identify 4 probable members of the 20 pc sample, 4 suspected double degenerate binaries, and we also report the discovery of two new ZZ Ceti pulsators

  20. User`s guide and documentation manual for ``PC-Gel`` simulator

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Ming-Ming; Gao, Hong W.

    1993-10-01

    PC-GEL is a three-dimensional, three-phase (oil, water, and gas) permeability modification simulator developed by incorporating an in-situ gelation model into a black oil simulator (BOAST) for personal computer application. The features included in the simulator are: transport of each chemical species of the polymer/crosslinker system in porous media, gelation reaction kinetics of the polymer with crosslinking agents, rheology of the polymer and gel, inaccessible pore volume to macromolecules, adsorption of chemical species on rock surfaces, retention of gel on the rock matrix, and permeability reduction caused by the adsorption of polymer and gel. The in-situ gelation model and simulator were validated against data reported in the literature. The simulator PC-GEL is useful for simulating and optimizing any combination of primary production, waterflooding, polymer flooding, and permeability modification treatments. A general background of permeability modification using crosslinked polymer gels is given in Section I and the governing equations, mechanisms, and numerical solutions of PC-GEL are given in Section II. Steps for preparing an input data file with reservoir and gel-chemical transport data, and recurrent data are described in Sections III and IV, respectively. Example data inputs are enclosed after explanations of each input line to help the user prepare data files. Major items of the output files are reviewed in Section V. Finally, three sample problems for running PC-GEL are described in Section VI, and input files and part of the output files of these problems are listed in the appendices. For the user`s reference a copy of the source code of PC-GEL computer program is attached in Appendix A.

  1. The upstream enhancer elements of the G6PC promoter are critical for optimal G6PC expression in murine glycogen storage disease type Ia.

    Science.gov (United States)

    Lee, Young Mok; Pan, Chi-Jiunn; Koeberl, Dwight D; Mansfield, Brian C; Chou, Janice Y

    2013-11-01

    Glycogen storage disease type-Ia (GSD-Ia) patients deficient in glucose-6-phosphatase-α (G6Pase-α or G6PC) manifest impaired glucose homeostasis characterized by fasting hypoglycemia, growth retardation, hepatomegaly, nephromegaly, hyperlipidemia, hyperuricemia, and lactic acidemia. Two efficacious recombinant adeno-associated virus pseudotype 2/8 (rAAV8) vectors expressing human G6Pase-α have been independently developed. One is a single-stranded vector containing a 2864-bp of the G6PC promoter/enhancer (rAAV8-GPE) and the other is a double-stranded vector containing a shorter 382-bp minimal G6PC promoter/enhancer (rAAV8-miGPE). To identify the best construct, a direct comparison of the rAAV8-GPE and the rAAV8-miGPE vectors was initiated to determine the best vector to take forward into clinical trials. We show that the rAAV8-GPE vector directed significantly higher levels of hepatic G6Pase-α expression, achieved greater reduction in hepatic glycogen accumulation, and led to a better toleration of fasting in GSD-Ia mice than the rAAV8-miGPE vector. Our results indicated that additional control elements in the rAAV8-GPE vector outweigh the gains from the double-stranded rAAV8-miGPE transduction efficiency, and that the rAAV8-GPE vector is the current choice for clinical translation in human GSD-Ia. © 2013.

  2. Correlation of random urine protein creatinine (P-C) ratio with 24-hour urine protein and P-C ratio, based on physical activity: a pilot study.

    Science.gov (United States)

    Sadjadi, Seyed-Ali; Jaipaul, Navin

    2010-09-07

    Quantification of proteinuria is usually predicated upon 24-hour urine collection. Multiple factors influence urine collection and the rate of protein and creatinine excretion. Urine collection is often incomplete, and therefore creatinine and protein excretion rates are underestimated. A random urine protein-creatinine (P-C) ratio has been shown over the years to be a reliable alternative to the 24-hour collection for detection and follow up of proteinuria. However, urine protein excretion may be influenced by physical activity. We studied 48 patients with proteinuria and varying levels of physical activity to determine the correlation between the measures of urine protein excretion. The correlation coefficient (r) between 24-hour urine total protein and random urine P-C ratio was 0.75 (P r = 0.99 (P r = 0.95 (P bedridden patients; r = 0.44 (P = not significant [NS]) and r = 0.54 (P = NS) in semiactive patients; and r = 0.44 (P = NS) and r = 0.58 (P 3500 mg/day) and non-nephrotic (r = 0.84; P r = 0.99 (P r = 0.92 (P bedridden patients; r = 0.61 (P = NS) and r = 0.54 (P = NS) in semiactive patients; and r = 0.64 (P r = 0.52 (P < 0.05) in active patients with nephrotic and non-nephrotic range proteinuria, respectively. We conclude that the random urine P-C ratio is a reliable and practical way of estimating and following proteinuria, but its precision and accuracy may be affected by the level of patient physical activity.

  3. Effect of cuprous halide interlayers on the device performance of ZnPc/C{sub 60} organic solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jinho; Park, Dasom; Heo, Ilsu; Yim, Sanggyu, E-mail: sgyim@kookmin.ac.kr

    2014-10-15

    Highlights: • Effect of CuX interlayers on subsequently deposited films and devices was studied. • CuI is the most effective for the performance of ZnPc/C{sub 60}-based solar cells. • Results were related to the molecular geometry of ZnPc and HOMO level of interlayers. - Abstract: The effect of various cuprous halide (CuX) interlayers introduced between a poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) layer and zinc phthalocyanine (ZnPc) layer on the physical properties of the ZnPc thin films and device performances of ZnPc/C{sub 60}-based small-molecule organic solar cells was studied. Strong substrate–molecule interaction between the CuX and ZnPc partly converted surface-perpendicular stacking geometry of ZnPc molecules into surface-parallel one. This flat-lying geometry led to an enhancement in electronic absorption and charge transport within the ZnPc films. As a result, the overall power conversion efficiency of the cell with CuI interlayer increased by ∼37%. In the case of the cells with CuBr and CuCl interlayer, however, the enhancement in device performances was limited because of the reduced conversion of the molecular geometry and increased energy barrier for hole extraction due to the low highest occupied molecular orbital level of the interlayer.

  4. Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC3/Tis21 knockout mice.

    Directory of Open Access Journals (Sweden)

    Stefano Farioli-Vecchioli

    Full Text Available Neurogenesis in the dentate gyrus of the adult hippocampus has been implicated in neural plasticity and memory, but the molecular mechanisms controlling the proliferation and differentiation of newborn neurons and their integration into the synaptic circuitry are still largely unknown. To investigate this issue, we have analyzed the adult hippocampal neurogenesis in a PC3/Tis21-null mouse model. PC3/Tis21 is a transcriptional co-factor endowed with antiproliferative and prodifferentiative properties; indeed, its upregulation in neural progenitors has been shown to induce exit from cell cycle and differentiation. We demonstrate here that the deletion of PC3/Tis21 causes an increased proliferation of progenitor cells in the adult dentate gyrus and an arrest of their terminal differentiation. In fact, in the PC3/Tis21-null hippocampus postmitotic undifferentiated neurons accumulated, while the number of terminally differentiated neurons decreased of 40%. As a result, PC3/Tis21-null mice displayed a deficit of contextual memory. Notably, we observed that PC3/Tis21 can associate to the promoter of Id3, an inhibitor of proneural gene activity, and negatively regulates its expression, indicating that PC3/Tis21 acts upstream of Id3. Our results identify PC3/Tis21 as a gene required in the control of proliferation and terminal differentiation of newborn neurons during adult hippocampal neurogenesis and suggest its involvement in the formation of contextual memories.

  5. Effect of cuprous halide interlayers on the device performance of ZnPc/C60 organic solar cells

    International Nuclear Information System (INIS)

    Lee, Jinho; Park, Dasom; Heo, Ilsu; Yim, Sanggyu

    2014-01-01

    Highlights: • Effect of CuX interlayers on subsequently deposited films and devices was studied. • CuI is the most effective for the performance of ZnPc/C 60 -based solar cells. • Results were related to the molecular geometry of ZnPc and HOMO level of interlayers. - Abstract: The effect of various cuprous halide (CuX) interlayers introduced between a poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) layer and zinc phthalocyanine (ZnPc) layer on the physical properties of the ZnPc thin films and device performances of ZnPc/C 60 -based small-molecule organic solar cells was studied. Strong substrate–molecule interaction between the CuX and ZnPc partly converted surface-perpendicular stacking geometry of ZnPc molecules into surface-parallel one. This flat-lying geometry led to an enhancement in electronic absorption and charge transport within the ZnPc films. As a result, the overall power conversion efficiency of the cell with CuI interlayer increased by ∼37%. In the case of the cells with CuBr and CuCl interlayer, however, the enhancement in device performances was limited because of the reduced conversion of the molecular geometry and increased energy barrier for hole extraction due to the low highest occupied molecular orbital level of the interlayer

  6. Behavioral abnormalities in prion protein knockout mice and the potential relevance of PrPc for the cytoskeleton

    Science.gov (United States)

    The cellular prion protein (PrPC) is a highly conserved protein, which is anchored to the outer surface of the plasma membrane. Even though its physiological function has already been investigated in different cell or mouse models where PrPC expression is either up-regulated or depleted, its exact p...

  7. The single-strand DNA binding activity of human PC4 preventsmutagenesis and killing by oxidative DNA damage

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jen-Yeu; Sarker, Altaf Hossain; Cooper, Priscilla K.; Volkert, Michael R.

    2004-02-01

    Human positive cofactor 4 (PC4) is a transcriptional coactivator with a highly conserved single-strand DNA (ssDNA) binding domain of unknown function. We identified PC4 as a suppressor of the oxidative mutator phenotype of the Escherichia coli fpg mutY mutant and demonstrate that this suppression requires its ssDNA binding activity. Yeast mutants lacking their PC4 ortholog Sub1 are sensitive to hydrogen peroxide and exhibit spontaneous and peroxide induced hypermutability. PC4 expression suppresses the peroxide sensitivity of the yeast sub l{Delta} mutant, suggesting that the human protein has a similar function. A role for yeast and human proteins in DNA repair is suggested by the demonstration that Sub1 acts in a peroxide-resistance pathway involving Rad2 and by the physical interaction of PC4 with the human Rad2 homolog XPG. We show XPG recruits PC4 to a bubble-containing DNA substrate with resulting displacement of XPG and formation of a PC4-DNA complex. We discuss the possible requirement for PC4 in either global or transcription-coupled repair of oxidative DNA damage to mediate the release of XPG bound to its substrate.

  8. Correlation of random urine protein creatinine (P-C ratio with 24-hour urine protein and P-C ratio, based on physical activity: a pilot study

    Directory of Open Access Journals (Sweden)

    Seyed-Ali Sadjadi

    2010-07-01

    Full Text Available Seyed-Ali Sadjadi1,2, Navin Jaipaul1,21Jerry L Pettis Memorial VA Medical Center, 2Loma Linda University School of Medicine, Loma Linda, CA, USAAbstract: Quantification of proteinuria is usually predicated upon 24-hour urine collection. Multiple factors influence urine collection and the rate of protein and creatinine excretion. Urine collection is often incomplete, and therefore creatinine and protein excretion rates are underestimated. A random urine protein-creatinine (P-C ratio has been shown over the years to be a reliable alternative to the 24-hour collection for detection and follow up of proteinuria. However, urine protein excretion may be influenced by physical activity. We studied 48 patients with proteinuria and varying levels of physical activity to determine the correlation between the measures of urine protein excretion. The correlation coefficient (r between 24-hour urine total protein and random urine P-C ratio was 0.75 (P < 0.01 in the overall study population, but varied according to the level of proteinuria and physical activity in a stratified analysis: r = 0.99 (P < 0.001 and r = 0.95 (P < 0.01 in bedridden patients; r = 0.44 (P = not significant [NS] and r = 0.54 (P = NS in semiactive patients; and r = 0.44 (P = NS and r = 0.58 (P < 0.05 in active patients with nephrotic- (>3500 mg/day and non-nephrotic (<3500 mg/day range proteinuria, respectively. The correlation appeared to be stronger between random urine and 24-hour urine P-C ratio for the overall study population (r = 0.84; P < 0.001, and when stratified according to the level of proteinuria and physical activity: r = 0.99 (P < 0.001 and r = 0.92 (P < 0.01 in bedridden patients; r = 0.61 (P = NS and r = 0.54 (P = NS in semiactive patients; and r = 0.64 (P < 0.02 and r = 0.52 (P < 0.05 in active patients with nephrotic and non-nephrotic range proteinuria, respectively. We conclude that the random urine P-C ratio is a reliable and practical way of estimating and

  9. The new generation of PowerPC VMEbus front end computers for the CERN SPS and LEP accelerators control system

    CERN Document Server

    Van den Eynden, M

    1995-01-01

    The CERN SPS and LEP PowerPC project is aimed at introducing a new generation of PowerPC VMEbus processor modules running the LynxOS real-time operating system. This new generation of front end computers using the state-of-the-art microprocessor technology will first replace the obsolete Xenix PC based systems (about 140 installations) successfully used since 1988 to control the LEP accelerator. The major issues addressed in the scope of this large scale project are the technical specification for the new PowerPC technology, the re-engineering aspects, the interfaces with other CERN wide projects, and the set up of a development environment. This project offers also support for other major SPS and LEP projects interested in the PowerPC microprocessor technology.

  10. The new generation of PowerPC VMEbus front end computers for the CERN SPS and LEP accelerators system

    CERN Document Server

    Charrue, P; Ghinet, F; Ribeiro, P

    1995-01-01

    The CERN SPS and LEP PowerPC project is aimed at introducing a new generation of PowerPC VMEbus processor modules running the LynxOS real-time operating system. This new generation of front end computers using the state-of-the-art microprocessor technology will first replace the obsolete XENIX PC based systems (about 140 installations) successfully used since 1988 to control the LEP accelerator. The major issues addressed in the scope of this large scale project are the technical specification for the new PowerPC technology, the re-engineering aspects, the interfaces with other CERN wide projects, and the set up of a development environment. This project offers also support for other major SPS and LEP projects interested in the PowerPC microprocessor technology.

  11. Application and verification of cold air velocity technique for solving tube ash erosion problem in PC boilers

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Kisoo; Jeong, Kwon Seok [Korea Southern Power Corporation, Gimhae (Korea, Republic of)

    2012-06-15

    Fly ash erosion is a leading cause of boiler tube failure in PC boilers. Therefore, shields or baffle plates are installed in specific areas to mitigate fly ash erosion and prevent boiler tube failure. However, the tube failure problems caused by fly ash erosion cannot be eliminated with this solution alone, because each PC boiler has a different flue gas flow pattern and erosion can become severe in unexpected zones. This problem is caused by an asymmetric internal flow velocity and local growth of the flue gas velocity. For these reasons, clearly defining the flow pattern in PC boilers is important for solving the problem of tube failure caused by fly ash erosion. For this purpose, the cold air velocity technique (CAVT) can be applied to the fly ash erosion problem. In this study, CAVT was carried out on the Hadong 2 PC boiler and the feasibility of application of CAVT to conventional PC boilers was validated.

  12. Application and verification of cold air velocity technique for solving tube ash erosion problem in PC boilers

    International Nuclear Information System (INIS)

    Yoo, Kisoo; Jeong, Kwon Seok

    2012-01-01

    Fly ash erosion is a leading cause of boiler tube failure in PC boilers. Therefore, shields or baffle plates are installed in specific areas to mitigate fly ash erosion and prevent boiler tube failure. However, the tube failure problems caused by fly ash erosion cannot be eliminated with this solution alone, because each PC boiler has a different flue gas flow pattern and erosion can become severe in unexpected zones. This problem is caused by an asymmetric internal flow velocity and local growth of the flue gas velocity. For these reasons, clearly defining the flow pattern in PC boilers is important for solving the problem of tube failure caused by fly ash erosion. For this purpose, the cold air velocity technique (CAVT) can be applied to the fly ash erosion problem. In this study, CAVT was carried out on the Hadong 2 PC boiler and the feasibility of application of CAVT to conventional PC boilers was validated

  13. PC-SEAPAK - ANALYSIS OF COASTAL ZONE COLOR SCANNER AND ADVANCED VERY HIGH RESOLUTION RADIOMETER DATA

    Science.gov (United States)

    Mcclain, C. R.

    1994-01-01

    PC-SEAPAK is a user-interactive satellite data analysis software package specifically developed for oceanographic research. The program is used to process and interpret data obtained from the Nimbus-7/Coastal Zone Color Scanner (CZCS), and the NOAA Advanced Very High Resolution Radiometer (AVHRR). PC-SEAPAK is a set of independent microcomputer-based image analysis programs that provide the user with a flexible, user-friendly, standardized interface, and facilitates relatively low-cost analysis of oceanographic satellite data. Version 4.0 includes 114 programs. PC-SEAPAK programs are organized into categories which include CZCS and AVHRR level-1 ingest, level-2 analyses, statistical analyses, data extraction, remapping to standard projections, graphics manipulation, image board memory manipulation, hardcopy output support and general utilities. Most programs allow user interaction through menu and command modes and also by the use of a mouse. Most programs also provide for ASCII file generation for further analysis in spreadsheets, graphics packages, etc. The CZCS scanning radiometer aboard the NIMBUS-7 satellite was designed to measure the concentration of photosynthetic pigments and their degradation products in the ocean. AVHRR data is used to compute sea surface temperatures and is supported for the NOAA 6, 7, 8, 9, 10, 11, and 12 satellites. The CZCS operated from November 1978 to June 1986. CZCS data may be obtained free of charge from the CZCS archive at NASA/Goddard Space Flight Center. AVHRR data may be purchased through NOAA's Satellite Data Service Division. Ordering information is included in the PC-SEAPAK documentation. Although PC-SEAPAK was developed on a COMPAQ Deskpro 386/20, it can be run on most 386-compatible computers with an AT bus, EGA controller, Intel 80387 coprocessor, and MS-DOS 3.3 or higher. A Matrox MVP-AT image board with appropriate monitor and cables is also required. Note that the authors have received some reports of

  14. Understanding the adsorption of CuPc and ZnPc on noble metal surfaces by combining quantum-mechanical modelling and photoelectron spectroscopy.

    Science.gov (United States)

    Huang, Yu Li; Wruss, Elisabeth; Egger, David A; Kera, Satoshi; Ueno, Nobuo; Saidi, Wissam A; Bucko, Tomas; Wee, Andrew T S; Zojer, Egbert

    2014-03-07

    Phthalocyanines are an important class of organic semiconductors and, thus, their interfaces with metals are both of fundamental and practical relevance. In the present contribution we provide a combined theoretical and experimental study, in which we show that state-of-the-art quantum-mechanical simulations are nowadays capable of treating most properties of such interfaces in a quantitatively reliable manner. This is shown for Cu-phthalocyanine (CuPc) and Zn-phthalocyanine (ZnPc) on Au(111) and Ag(111) surfaces. Using a recently developed approach for efficiently treating van der Waals (vdW) interactions at metal/organic interfaces, we calculate adsorption geometries in excellent agreement with experiments. With these geometries available, we are then able to accurately describe the interfacial electronic structure arising from molecular adsorption. We find that bonding is dominated by vdW forces for all studied interfaces. Concomitantly, charge rearrangements on Au(111) are exclusively due to Pauli pushback. On Ag(111), we additionally observe charge transfer from the metal to one of the spin-channels associated with the lowest unoccupied π-states of the molecules. Comparing the interfacial density of states with our ultraviolet photoelectron spectroscopy (UPS) experiments, we find that the use of a hybrid functionals is necessary to obtain the correct order of the electronic states.

  15. Understanding the Adsorption of CuPc and ZnPc on Noble Metal Surfaces by Combining Quantum-Mechanical Modelling and Photoelectron Spectroscopy

    Directory of Open Access Journals (Sweden)

    Yu Li Huang

    2014-03-01

    Full Text Available Phthalocyanines are an important class of organic semiconductors and, thus, their interfaces with metals are both of fundamental and practical relevance. In the present contribution we provide a combined theoretical and experimental study, in which we show that state-of-the-art quantum-mechanical simulations are nowadays capable of treating most properties of such interfaces in a quantitatively reliable manner. This is shown for Cu-phthalocyanine (CuPc and Zn-phthalocyanine (ZnPc on Au(111 and Ag(111 surfaces. Using a recently developed approach for efficiently treating van der Waals (vdW interactions at metal/organic interfaces, we calculate adsorption geometries in excellent agreement with experiments. With these geometries available, we are then able to accurately describe the interfacial electronic structure arising from molecular adsorption. We find that bonding is dominated by vdW forces for all studied interfaces. Concomitantly, charge rearrangements on Au(111 are exclusively due to Pauli pushback. On Ag(111, we additionally observe charge transfer from the metal to one of the spin-channels associated with the lowest unoccupied π-states of the molecules. Comparing the interfacial density of states with our ultraviolet photoelectron spectroscopy (UPS experiments, we find that the use of a hybrid functionals is necessary to obtain the correct order of the electronic states.

  16. Chichibu park bridge, a Japan's longest PC cable suspension bridge that attaches importance to scenery. Keikan wo jushishita Nippon saidai no PC shachokyo 'Chichibu koenkyo'

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-01

    This paper introduces the feature of Chichibu Park Bridge, a Japan's longest PC cable suspension bridge that attaches importance to scenery. The maximum effective span of Chichibu Park Bridge which is a two-span continuous PC cable suspension bridge measures 195 m, that means the center span length is equivalent to about 400 m if converted to a three-span structure. With respect to the design that values the scenic effect, the main tower has relief engravings of stone carving tone using Chichibu Night Festival as a motif disposed around it; lighting up is applied to the main tower to highlight it so that it can be viewed from far away places; and a balcony is built on the center of the bridge. Chichibu Park Bridge has the bridge axial direction stagger with the river flow direction at 45[degree] to reduce water resistance. The tensile force generated at the corbel section according to the main tower reactive force is dealt with reinforced concrete rather than with prestressed concrete. The main tower adopts a two-chamber girder structure as its cross section shape from the view points of rigidity assurance and scenic effect. For construction control, micro computers are used to correct growing change in bend of the main girder due to temperature change and cable tension change. 6 figs., 4 tabs.

  17. Vertical vibration control system for PC cable-stayed bridge during cantilever construction; Shuketa jogedo seishin sochi ni yoru haridashi sekoji no PC shachokyo no seishin

    Energy Technology Data Exchange (ETDEWEB)

    Oshio, M.; Nakano, R.; Niihara, Y.; Yano, K.; Takeda, T. [Kajima Corp., Tokyo (Japan)

    1995-12-20

    A PC cable-stayed bridge under extension construction having long span length may have long-cycle vibration generated because of wind. The vibration puts workers working on main girders into a state of seasick causing the workability to drop. Therefore, with an objective to reduce vibration occurring on the main girders during construction, discussions were given on application of an active type vertical vibration absorbing device. The vibration absorbing device is an active system that a weight is driven vertically by a hydraulic actuator. The device was developed with a target that damping ratio when a maximum extension is 120 m becomes three times that when no vibration is absorbed for a 5-span continuous PC cable-stayed bridge with a length of 675 m, a central span of 260 m, and a width of 11 m. A cage housing the weight is connected with the actuator at its top by using pins, and the weight is supported being suspended from the top of the actuator. Vibration is absorbed by utilizing reactive force generated when the weight is driven vertically by the hydraulic actuator. The hydraulic actuator contains a gas spring that supports the dead weight of the weight. Experiments have verified the effectiveness of the vertical vibration absorbing device. 4 refs., 12 figs., 3 tabs.

  18. Chitosan (biochikol 020 PC) in the control of some ornamental foliage diseases.

    Science.gov (United States)

    Wojdyła, A T

    2004-01-01

    Chitosan, (Biochikol 020 PC) a potential elicitor of plant defence and also an active inhibitor of fungal growth was used in experiments. The compound was used at concentrations 0.01 to 0.2% as a plant spray for rose protection against Sphaerotheca pannosa var. rosae, Peronospora sparsa and Diplocarpon rosae, Oidium chrysanthemi and Puccinia horiana on chrysanthemum, against Melampsora epitea on willow. Myrothecium roridum on dieffenbachia and against Lophodermium spp on Scots pine. Effectiveness of this product, applied curatively 2-times at 7-day-intervals after appearance of rose powdery mildew symptoms on most of plant parts, was about 32%. When compound was applied just after the first disease symptoms appearance, after 2-week-protection its effectiveness was about 43-60%. After 4 weeks, effectiveness of chitosan (Biochikol 020 PC) increased and ranged from 67 to 77%. In the control of P. sparsa on rose shrubs, growing in plastic tunnel, chitosan at conc. 0.025% was applied 4 times at weekly intervals. Effectiveness of chitosan against this pathogen was over 72%, similar as standard fungicide. Increase of chitosan (Biochikol 020 PC) concentration resulted in decrease of its effectiveness. In case of D. rosae control, chitosan used 9 times at weekly intervals was applied after first disease symptoms. After 3-week-protection effectiveness of the compound varied from 18 to 60% according to used concentration. After 9 weeks of protection effectiveness of tested product ranged from 16 to 23% and was connected with used concentration. Increase of chitosan concentration resulted in better protection of rose shrubs. Effectiveness of chitosan (Biochikol 020 PC) used 4-times at conc. 0.01 to 0.05% as chrysanthemum spray in the control of Oidium chrysanthemi ranged from 69 to 79%, whereas against Puccinia horiana from 54-97%. Two-time-spraying of willow with rust symptoms (Melampsora epitea) with chitosan at conc. 01-0.04% caused decrease of disease severity from 26 to

  19. Using the AUDIT-PC to predict alcohol withdrawal in hospitalized patients.

    Science.gov (United States)

    Pecoraro, Anna; Ewen, Edward; Horton, Terry; Mooney, Ruth; Kolm, Paul; McGraw, Patty; Woody, George

    2014-01-01

    Alcohol withdrawal syndrome (AWS) occurs when alcohol-dependent individuals abruptly reduce or stop drinking. Hospitalized alcohol-dependent patients are at risk. Hospitals need a validated screening tool to assess withdrawal risk, but no validated tools are currently available. To examine the admission Alcohol Use Disorders Identification Test-(Piccinelli) Consumption (AUDIT-PC) ability to predict the subsequent development of AWS among hospitalized medical-surgical patients admitted to a non-intensive care setting. Retrospective case–control study of patients discharged from the hospital with a diagnosis of AWS. All patients with AWS were classified as presenting with AWS or developing AWS later during admission. Patients admitted to an intensive care setting and those missing AUDIT-PC scores were excluded from analysis. A hierarchical (by hospital unit) logistic regression was performed and receiver-operating characteristics were examined on those developing AWS after admission and randomly selected controls. Because those diagnosing AWS were not blinded to the AUDIT-PC scores, a sensitivity analysis was performed. The study cohort included all patients age ≥18 years admitted to any medical or surgical units in a single health care system from 6 October 2009 to 7 October 2010. After exclusions, 414 patients were identified with AWS. The 223 (53.9 %) who developed AWS after admission were compared to 466 randomly selected controls without AWS. An AUDIT-PC score ≥4 at admission provides 91.0 % sensitivity and 89.7 % specificity (AUC=0.95; 95 % CI, 0.94–0.97) for AWS, and maximizes the correct classification while resulting in 17 false positives for every true positive identified. Performance remained excellent on sensitivity analysis (AUC=0.92; 95 % CI, 0.90–0.93). Increasing AUDIT-PC scores were associated with an increased risk of AWS (OR=1.68, 95 % CI 1.55–1.82, pAUDIT-PC score is an excellent discriminator of AWS and could be an important component

  20. Plasma Cell Alloantigen 1 and IL-10 Secretion Define Two Distinct Peritoneal B1a B Cell Subsets With Opposite Functions, PC1high Cells Being Protective and PC1low Cells Harmful for the Growing Fetus

    Directory of Open Access Journals (Sweden)

    Anne Schumacher

    2018-05-01

    Full Text Available B cells possess various immuno regulatory functions. However, research about their participation in tolerance induction toward the fetus is just emerging. Accumulating evidence supports the idea that B cells can play seemingly conflicting roles during pregnancy, either protecting or harming the fetus. Previous findings indicated the presence of two different peritoneal B cell subsets, defined by the expression of the plasma cell alloantigen 1 (PC1 and with distinct immune modulatory functions. Here, we aimed to study the participation of these two B cell subsets, on pregnancy outcome in a murine model of disturbed fetal tolerance. The frequencies and cell numbers of peritoneal and splenic CD19+IL-10+ and CD19+CD5+IL-10+PC1+ cells were assessed in virgin as well as normal pregnant (NP and abortion-prone (AP females during the course of gestation. Peritoneal PC1low or PC1high B1a B cells were sorted, analyzed for their ability to secrete IL-10 and adoptively transferred into NP or AP females. On gestation day (gd 12, the abortion rate as well as the frequencies and cell numbers of regulatory T cells, TH1 and TH17 cells were determined in spleens and decidua. In addition, mRNA expression of IL-10, TGF-β, IFN-γ, and TNF-α was analyzed in decidual tissue. Peritoneal CD19+IL-10+ and CD19+CD5+IL-10+PC1+ frequencies fluctuated during the progression of normal pregnancies while no significant changes were observed in spleen. AP females showed significantly reduced frequencies of both B cell populations and exhibited an altered peritoneal PC1high/PC1low ratio at gd10. Adoptive transfers of PC1low B1a B cells into NP females increased the abortion rate in association with a reduced splenic regulatory T/TH17 ratio. By contrast, the transfer of PC1high B1a B cells into AP females significantly diminished the fetal rejection rate and significantly reduced the numbers of splenic TH17 cells. Our results suggest that the peritoneum harbors two distinct B1a B

  1. Evolution of nanodot morphology on polycarbonate (PC) surfaces by 40 keV Ar{sup +}

    Energy Technology Data Exchange (ETDEWEB)

    Goyal, Meetika, E-mail: meetika89@gmail.com; Chawla, Mahak; Gupta, Divya; Shekhawat, Nidhi; Sharma, Annu; Aggarwal, Sanjeev [Department of Physics, Kurukshetra University, Kurukshetra - 136119 (India)

    2016-05-06

    In the present paper we have discussed the effect of 40 keV Ar{sup +} ions irradiation on nanoscale surface morphology of Polycarbonate (PC) substrate. Specimens were sputtered at off normal incidences of 30°, 40° and 50° with the fluence of 1 × 10{sup 16} Ar{sup +}cm{sup −2}. The topographical behaviour of specimens was studied by using Atomic Force Microscopy (AFM) technique. AFM study demonstrates the evolution of nano dot morphology on PC specimens on irradiating with 1 × 10{sup 16} Ar{sup +}cm{sup −2}. Average size of dots varied from 37-95 nm in this specified range of incidence while density of dots varied from 0.17-3.0 × 107 dotscm{sup −2}. Such variations in morphological features have been supported by estimation of ion range and sputtering yield through SRIM simulations.

  2. Proposal for the Award of a Blanket Purchase Contract for the Supply of PC Servers

    CERN Document Server

    2003-01-01

    This document concerns the award of a contract for the supply and the hardware support of Windows compatible PC servers for a three-year period with a view to maintaining and evolving CERN's Windows infrastructure over the coming years. Following a market survey carried out among 38 firms in eleven Member States, a call for tenders (IT-2955/IT) was sent on 27 January 2003 to six firms in two Member States. By the closing date, CERN had received two tenders from two firms in one Member State. The Finance Committee is invited to agree to the negotiation of a three-year blanket purchase contract with ELONEX (CH), the lowest bidder complying with the specification, for the supply of Windows compatible PC servers for a total amount not exceeding 1 100 000 Swiss francs, not subject to revision. The firm has indicated the following distribution by country of the contract value covered by this adjudication proposal: GB - 100%.

  3. Single NdPc{sub 2} molecules on surfaces. Adsorption, interaction, and molecular magnetism

    Energy Technology Data Exchange (ETDEWEB)

    Fahrendorf, Sarah

    2013-01-24

    They have huge potential for application in molecular-spin-transistors, molecular-spinvalves, and molecular quantum computing. SMMs are characterized by high spin ground states with zero-field splitting leading to high relaxation barriers and long relaxation times. A relevant class of molecules are the lanthanide double-decker phthalocyanines (LaPc{sub 2}) with only one metal atom sandwiched between two organic phthalocyanine (Pc) ligands. For envisaged spintronic applications it is important to understand the interaction between the molecules and the substrate and its influence on the electronic and magnetic properties. The subject of this thesis is the investigation of the adsorbed neodymium double-decker phthalocyanine (NdPc{sub 2}) by means of low temperature scanning tunneling microscopy and spectroscopy (STM and STS). The molecules are deposited by sublimation onto different substrates. It is observed that a large fraction of the double-decker molecules decomposes during deposition. The decomposition probability strongly depends on the chosen substrate. Therefore it is concluded that the substrate modifies the electronic structure of the molecule leading to a stabilization or destabilization of the molecular entity. Charge transfer from the surface to the molecule is identified as a potential stabilizing mechanism. The electronic and magnetic properties are investigated in detail for adsorbed NdPc{sub 2} molecules on Cu(100). The results of the experimental study are compared to state-of-the-art density functional theory calculations performed by our colleagues from the Peter Gruenberg Institute (PGI-1) at the Forschungszentrum Juelich. Interestingly, the lower Pc ring of the molecule hybridizes intensely with the substrate leading to strong chemisorption of the molecule, while the upper Pc ring keeps its molecular type electronic states, which can be energetically shifted by an external electric field. Importantly, it is possible to get direct access to the

  4. Evolution of nanodot morphology on polycarbonate (PC) surfaces by 40 keV Ar"+

    International Nuclear Information System (INIS)

    Goyal, Meetika; Chawla, Mahak; Gupta, Divya; Shekhawat, Nidhi; Sharma, Annu; Aggarwal, Sanjeev

    2016-01-01

    In the present paper we have discussed the effect of 40 keV Ar"+ ions irradiation on nanoscale surface morphology of Polycarbonate (PC) substrate. Specimens were sputtered at off normal incidences of 30°, 40° and 50° with the fluence of 1 × 10"1"6 Ar"+cm"−"2. The topographical behaviour of specimens was studied by using Atomic Force Microscopy (AFM) technique. AFM study demonstrates the evolution of nano dot morphology on PC specimens on irradiating with 1 × 10"1"6 Ar"+cm"−"2. Average size of dots varied from 37-95 nm in this specified range of incidence while density of dots varied from 0.17-3.0 × 107 dotscm"−"2. Such variations in morphological features have been supported by estimation of ion range and sputtering yield through SRIM simulations.

  5. Trial operation of a phosphoric acid fuel cell (PC25) for CHP applications in Europe

    Energy Technology Data Exchange (ETDEWEB)

    Uhrig, M.; Droste, W.; Wolf, D. [Ruhrgas AG, Dorsten (Germany)

    1996-12-31

    In Europe, ten 200 kW phosphoric acid fuel cells (PAFCs) produced by ONSI (PC25) are currently in operation. Their operators collaborate closely in the European Fuel Cell Users Group (EFCUG). The experience gained from trial operation by the four German operators - HEAG, HGW/HEW, Thyssengas and Ruhrgas - coincides with that of the other European operators. This experience can generally be regarded as favourable. With a view to using fuel cells in combined heat and power generation (CHP), the project described in this report, which was carried out in cooperation with the municipal utility of Bochum and Gasunie of the Netherlands, aimed at gaining experience with the PC 25 in field operation under the specific operating conditions prevailing in Europe. The work packages included heat-controlled operation, examination of plant behavior with varying gas properties and measurement of emissions under dynamic load conditions. The project received EU funding under the JOULE programme.

  6. An Auto sequence Code to Integrate a Neutron Unfolding Code with thePC-MCA Accuspec

    International Nuclear Information System (INIS)

    Darsono

    2000-01-01

    In a neutron spectrometry using proton recoil method, the neutronunfolding code is needed to unfold the measured proton spectrum to become theneutron spectrum. The process of the unfolding neutron in the existingneutron spectrometry which was successfully installed last year was doneseparately. This manuscript reports that the auto sequence code to integratethe neutron unfolding code UNFSPEC.EXE with the software facility of thePC-MCA Accuspec has been made and run successfully so that the new neutronspectrometry become compact. The auto sequence code was written based on therules in application program facility of PC-MCA Accuspec and then it wascompiled using AC-EXE. Result of the test of the auto sequence code showedthat for binning width 20, 30, and 40 giving a little different spectrumshape. The binning width around 30 gives a better spectrum in mean of givingsmall error compared to the others. (author)

  7. Portable regional cerebral blood flow system based on IBM PC/AT and microprocessor electronics

    International Nuclear Information System (INIS)

    Mun, S.K.; Mun, I.K.; Petite, J.; Cohan, S.L.; Fahey, F.H.

    1986-01-01

    A portable 16-channel reginal cerebral blood flow (rCBF) measuring system has been developed using an IBM PC/AT and new microelectronics to improve processing speed and portability. The detector electronics were developed by Scan Detectronics A/S of Denmark. The counter module contains 18 16-bit counters, each programmable in four different modes. The rate meter has three independent microprocessor controllers for rate meter functions, window controller, and channel controller. The detector electronics and detection parameters can be fully controlled by the host PC/AT. The menu-driven system (Better Basic) assists the operator at each step. The collected data from 16 channels can be processed automatically or postprocessed using more flexible and sophisticated techniques within 20 minutes. The headgear holding 16 sodium iodide detectors is fabricated by modifying a motorcycle helmet

  8. Internet2-based 3D PET image reconstruction using a PC cluster

    International Nuclear Information System (INIS)

    Shattuck, D.W.; Rapela, J.; Asma, E.; Leahy, R.M.; Chatzioannou, A.; Qi, J.

    2002-01-01

    We describe an approach to fast iterative reconstruction from fully three-dimensional (3D) PET data using a network of PentiumIII PCs configured as a Beowulf cluster. To facilitate the use of this system, we have developed a browser-based interface using Java. The system compresses PET data on the user's machine, sends these data over a network, and instructs the PC cluster to reconstruct the image. The cluster implements a parallelized version of our preconditioned conjugate gradient method for fully 3D MAP image reconstruction. We report on the speed-up factors using the Beowulf approach and the impacts of communication latencies in the local cluster network and the network connection between the user's machine and our PC cluster. (author)

  9. Statistical Analysis of Deflation in Covariance and Resultant Pc Values for AQUA, AURA and TERRA

    Science.gov (United States)

    Hasan, Syed O.

    2016-01-01

    This presentation will display statistical analysis performed for raw conjunction CDMs received for the EOS Aqua, Aura and Terra satellites within the period of February 2015 through July 2016. The analysis performed indicates a discernable deflation in covariance calculated at the JSpOC after the utilization of the dynamic drag consider parameter was implemented operationally in May 2015. As a result, the overall diminution in the conjunction plane intersection of the primary and secondary objects appears to be leading to reduced probability of collision (Pc) values for these conjunction events. This presentation also displays evidence for this theory with analysis of Pc trending plots using data calculated by the SpaceNav CRMS system.

  10. Microspot two-photon photoemission spectroscopy for CuPc film on HOPG

    International Nuclear Information System (INIS)

    Yamada, T.; Yamamoto, R.; Munakata, T.

    2015-01-01

    Highlights: • Unoccupied levels of CuPc/HOPG are assigned by using 2PPE microspectroscopy. • Lateral distribution of unoccupied energy levels is imaged. • Modified IPS stabilized by the hole localized in the 2nd layer molecule is identified. - Abstract: Microspot two-photon photoemission (micro-2PPE) spectroscopy has been applied to measure the lateral distribution of unoccupied levels on copper phthalocyanine (CuPc) film on HOPG. In addition to the LUMO-derived level and the image potential state (IPS) on the film, we identified the modified IPS which is stabilized by the hole localized in a molecule. We show that modified IPS is observed only on bilayer area, reflecting the localization of the hole in a molecule. The modified IPS is absent on monolayer area, because the hole strongly interacts with substrate.

  11. Cross-compilation of ATLAS online software to the power PC-Vx works system

    International Nuclear Information System (INIS)

    Tian Yuren; Li Jin; Ren Zhengyu; Zhu Kejun

    2005-01-01

    BES III, selected ATLAS online software as a framework of its run-control system. BES III applied Power PC-VxWorks system on its front-end readout system, so it is necessary to cross-compile this software to PowerPC-VxWorks system. The article demonstrates several aspects related to this project, such as the structure and organization of the ATLAS online software, the application of CMT tool while cross-compiling, the selection and configuration of the cross-compiler, methods to solve various problems due to the difference of compiler and operating system etc. The software, after cross-compiling, can normally run, and makes up a complete run-control system with the software running on Linux system. (authors)

  12. Development of PC based data acquisition system for universal test machine

    International Nuclear Information System (INIS)

    Nageswara Rao, T.S.V.R.; Hari Prasad, V.; Satyadev, B.; Banarjee, P.K.

    2010-01-01

    To determine the tensile properties of nuclear fuel tubes and other components, the Universal Test Machine is being used in Material testing section of Quality Assurance, NFC. This machine consists of Chart Recorder to chart the Load Vs. Strain graph. The tensile properties of the test material viz. Ultimate Tensile Strength (UTS), Yield Strength (YS), and Young's Modulus (e) etc. are usually determined by graphical method using a ruler. To overcome the problems faced due to embargo and non-availability of spares of recorder, a PC based Data Acquisition System (DAS) with necessary software algorithm was developed for automatic calculation of tensile properties by extracting the linear portion of tensile test curve where the Tangent and Secant Modulus coincide, without intervention of the user. This developmental work reduces human error in calculation, facilitates the use of state-of-the art technology and the risk of obsolescence by employing PC based architecture. (author)

  13. Interfacing of thermal ionization mass spectrometer with PC/XT and related software development

    International Nuclear Information System (INIS)

    Moorthy, A.D.; Gurba, P.B.; Rajendrakumar; Singh, R.K.; Bajpai, D.D.; Coelho, G.J.M.; Das, K.V.; Indurkar, V.S.

    1992-01-01

    A completely automated Thermal Ionization Mass Spectrometer (TIMS), is used in Power Reactor Fuel Reprocessing Plant (PREFRE) Tarapur for precise and accurate measurement of isotopic composition and concentration determination of special nuclear materials (Uranium and Plutonium) for the purpose of input accounting of the plant. It is provided with one Hewlett-Packard, H-9845B desktop computer to control various instrument parameters and perform automatic analysis of 13 samples in sequence. The computer gave fairly good service for six years with intermittent minor maintenance before it developed major problems. In view of the fact that its repair and maintenance cost is several times the cost of locally available computer, it was decided to replace the imported Hewlett-Packard 9845B desktop computer with PC/XT. This report describes the interfacing of TIMS with PC/XT and the related Software development. (author). 3 refs., 8 figs., 2 annexures

  14. A New PC and LabVIEW Package Based System for Electrochemical Investigations.

    Science.gov (United States)

    Stević, Zoran; Andjelković, Zoran; Antić, Dejan

    2008-03-15

    The paper describes a new PC and LabVIEW software package based system forelectrochemical research. An overview of well known electrochemical methods, such aspotential measurements, galvanostatic and potentiostatic method, cyclic voltammetry andEIS is given. Electrochemical impedance spectroscopy has been adapted for systemscontaining large capacitances. For signal generation and recording of the response ofinvestigated electrochemical cell, a measurement and control system was developed, basedon a PC P4. The rest of the hardware consists of a commercially available AD-DA converterand an external interface for analog signal processing. The interface is a result of authorsown research. The software platform for desired measurement methods is LabVIEW 8.2package, which is regarded as a high standard in the area of modern virtual instruments. Thedeveloped system was adjusted, tested and compared with commercially available systemand ORCAD simulation.

  15. Single NdPc2 molecules on surfaces. Adsorption, interaction, and molecular magnetism

    International Nuclear Information System (INIS)

    Fahrendorf, Sarah

    2013-01-01

    They have huge potential for application in molecular-spin-transistors, molecular-spinvalves, and molecular quantum computing. SMMs are characterized by high spin ground states with zero-field splitting leading to high relaxation barriers and long relaxation times. A relevant class of molecules are the lanthanide double-decker phthalocyanines (LaPc 2 ) with only one metal atom sandwiched between two organic phthalocyanine (Pc) ligands. For envisaged spintronic applications it is important to understand the interaction between the molecules and the substrate and its influence on the electronic and magnetic properties. The subject of this thesis is the investigation of the adsorbed neodymium double-decker phthalocyanine (NdPc 2 ) by means of low temperature scanning tunneling microscopy and spectroscopy (STM and STS). The molecules are deposited by sublimation onto different substrates. It is observed that a large fraction of the double-decker molecules decomposes during deposition. The decomposition probability strongly depends on the chosen substrate. Therefore it is concluded that the substrate modifies the electronic structure of the molecule leading to a stabilization or destabilization of the molecular entity. Charge transfer from the surface to the molecule is identified as a potential stabilizing mechanism. The electronic and magnetic properties are investigated in detail for adsorbed NdPc 2 molecules on Cu(100). The results of the experimental study are compared to state-of-the-art density functional theory calculations performed by our colleagues from the Peter Gruenberg Institute (PGI-1) at the Forschungszentrum Juelich. Interestingly, the lower Pc ring of the molecule hybridizes intensely with the substrate leading to strong chemisorption of the molecule, while the upper Pc ring keeps its molecular type electronic states, which can be energetically shifted by an external electric field. Importantly, it is possible to get direct access to the spin

  16. Antiferromagnetic coupling of TbPc2 molecules to ultrathin Ni and Co films

    Directory of Open Access Journals (Sweden)

    David Klar

    2013-05-01

    Full Text Available The magnetic and electronic properties of single-molecule magnets are studied by X-ray absorption spectroscopy and X-ray magnetic circular dichroism. We study the magnetic coupling of ultrathin Co and Ni films that are epitaxially grown onto a Cu(100 substrate, to an in situ deposited submonolayer of TbPc2 molecules. Because of the element specificity of the X-ray absorption spectroscopy we are able to individually determine the field dependence of the magnetization of the Tb ions and the Ni or Co film. On both substrates the TbPc2 molecules couple antiferromagnetically to the ferromagnetic films, which is possibly due to a superexchange interaction via the phthalocyanine ligand that contacts the magnetic surface.

  17. Effects of Aroclor 1254 on dopamine and norepinephrine concentrations in pheochromocytoma (PC-12) cells

    International Nuclear Information System (INIS)

    Seegal, R.F.; Brosch, K.; Bush, B.; Ritz, M.; Shain, W.

    1990-01-01

    Pheochromocytoma (PC-12) cells synthesize, store, release and metabolize dopamine (DA) and norepinephrine (NE) in a manner analogous to that observed in the mammalian central nervous system. These cells were used to develop and validate an alternate method to animal testing to assess the effects of a complex environmental mixture of polychlorinated biphenyls (Aroclor 1254) on cellular catecholamine function. Aroclor 1254, at concentrations of 1 to 100 ppm, significantly decreased cellular catecholamine concentrations after 6 hrs. Exposure at 100 ppm for periods of less than an hr increased cellular catecholamine concentrations while longer exposure times (i.e., 1 to 24 hr) decreased cellular catecholamine concentrations. This in vitro depletion of catecholamines is similar to that seen in vivo. Thus, PC-12 cells may be useful for neurochemical evaluation of neurotoxicants with particular reference to effects on catecholaminergic systems

  18. ALOFT-PC a smoke plume trajectory model for personal computers

    International Nuclear Information System (INIS)

    Walton, W.D.; McGrattan, K.B.; Mullin, J.V.

    1996-01-01

    A computer model, named ALOFT-PC, was developed for use during in-situ burning of oil spills to predict smoke plume trajectory. The downwind distribution of smoke particulate is a complex function of fire parameters, meteorological conditions, and topographic features. Experimental burns have shown that the downwind distribution of smoke is not Gaussian and simple smoke plume models do not capture the observed plume features. ALOFT-PC consists of the Navier-Stokes equations using an eddy viscosity over a uniform grid that spans the smoke plume and its surroundings. The model inputs are wind speed and variability, atmospheric temperature profile, and fire parameters and the output is the average of the plume. 7 refs., 3 tabs

  19. Efficacy of magnetoacustoradiation treatment of experimental M-1, PC-1 tumors

    International Nuclear Information System (INIS)

    Chizh, D.V.; Krutilina, N.I.

    2011-01-01

    The urgency of the struggle against malignant tumors is determined by a stable growth of cancer incidence, high level of disability and morbidity, the cost and difficulty of treatment. The influence of low-frequency ultrasound and alternating magnetic field on transplanted tumors of sarcoma M-1 and alveolar liver cancer PC-1 together with radiation therapy at a SFD of 5 Gy and 20 Gy was investigated in the experiments on animals. It was established that the influence of the above physical factors inhibited sarcoma M-1 and alveolar liver cancer PC-1 growth, prolonged the life and survival of the animals of the investigated groups when compared to the intact controls, which definitely expanded the ideas about the capabilities of ultrasound and magnetic fields in cancer treatment.

  20. SALP-PC, a computer program for fault tree analysis on personal computers

    International Nuclear Information System (INIS)

    Contini, S.; Poucet, A.

    1987-01-01

    The paper presents the main characteristics of the SALP-PC computer code for fault tree analysis. The program has been developed in Fortran 77 on an Olivetti M24 personal computer (IBM compatible) in order to reach a high degree of portability. It is composed of six processors implementing the different phases of the analysis procedure. This particular structure presents some advantages like, for instance, the restart facility and the possibility to develop an event tree analysis code. The set of allowed logical operators, i.e. AND, OR, NOT, K/N, XOR, INH, together with the possibility to define boundary conditions, make the SALP-PC code a powerful tool for risk assessment. (orig.)

  1. A PC-based Flexible Solution for Virtual Instrumentation of a Multi-Purpose Test Bed

    Directory of Open Access Journals (Sweden)

    Benatzky Christian

    2006-11-01

    Full Text Available The aim of the paper is to give an overview of a test bed set up for lightweight flexible structures. The purpose of the test bed is to compare different concepts for suppressing structural vibrations. It is demonstrated that such a complex measurement and actuation task can be easily implemented on a single PC using standard software like Matlab/SIMULINK® with a minimum of custom hardware. With the help of this PC standard engineering tasks like measuring, identification of transfer functions, as well as controller design and implementation in soft real-time can be carried out easily (rapid prototyping. The resulting system is flexible and scalable, enabling an engineer to perform all the above mentioned tasks for a given test object within minimum time. Additionally, the utilization of Matlab/SIMULINK® facilitates the realization of a versatile virtual instrumentation system which is easy to use and may also be remote-controlled.

  2. An advanced lab frame PC-PLC regime for a power supply control

    International Nuclear Information System (INIS)

    Abdel-Bary, M

    2010-01-01

    A lab frame automatic control system (LFACS) based on a programmable logic controller (PLC) is designed, developed and tested in the laboratory. The LFACS is designed to control and monitor one DC power supply with output current accuracy 0.001 amps, one automatic valve. Also the LFACS will monitor one full range vacuum measurement and one water leak detector. The control system is built based on the internationally standard programmable logic controller (PLC) from Siemens. Two software's have been used; firstly SIMATIC S 7 lite has been used to build the control program and safety interlocks, secondly winCC flexible (runs in a PC computer and communicates with the PLC by multi point interface PC adapter (MPI) has been used to build the user-machine interface . This lab frame control system will be generalized to a global control system to control the MGC-20 cyclotron. The lab tests showed a reliable and flexible control system.

  3. Neutron shielding point kernel integral calculation code for personal computer: PKN-pc

    International Nuclear Information System (INIS)

    Kotegawa, Hiroshi; Sakamoto, Yukio; Nakane, Yoshihiro; Tomita, Ken-ichi; Kurosawa, Naohiro.

    1994-07-01

    A personal computer version of PKN code, PKN-pc, has been developed to calculate neutron and secondary gamma-ray 1cm depth dose equivalents in water, ordinary concrete and iron for neutron source. Characteristics of PKN code are, to able to calculate dose equivalents in multi-layer three-dimensional system, which are described with two-dimensional surface, for monoenergetic neutron source from 0.01 to 14.9 MeV, 252 Cf fission and 241 Am-Be neutron source quick and easily. In addition to these features, the PKN-pc is possible to process interactive input and to get graphical system configuration and graphical results easily. (author)

  4. [Subluxation of scleral-fixated PC IOL caused by polypropylene suture degradation--case report].

    Science.gov (United States)

    Kanigowska, Krystyna; Grałek, Mirosława; Czarnowska, Elzbieta; Zajaczkowska, Agnieszka

    2009-01-01

    The purpose of the study is to evaluate factors related to late-onset of lens subluxation in transscleral sutured posterior chamber IOL. We report a child, which required surgical treatment for dislocation of a scleral-sutured PC IOL. 11 years earlier the secondary lens implantation with scleral fixation was performed in 4 years old boy. The first surgical procedure included an anterior victrectomy and suturing a single- piece PMMA IOL under the scleral flaps with a 10-0 polipropylene suture. The second--included explantation of the dislocated lens. Optic and scanning electron microscopy was used to analyze the surface of the explanted remnants of the breakage suture. Microscopic findings indicate that the late suture breakage and subluxation of suture-fixated PC IOL was due to the degradation of polypropylene suture.

  5. Cholecystokinin-2 receptor mediated gene expression in neuronal PC12 cells

    DEFF Research Database (Denmark)

    Hansen, Thomas v O; Borup, Rehannah; Marstrand, Troels

    2007-01-01

    could be identified. Comparison with forskolin- and nerve growth factor (NGF)-treated PC12 cells showed that CCK induced a separate set of target genes. Taken together, we propose that neuronal CCK may have a role in the regulation of the circadian rhythm, the metabolism of cerebral cholesterol...... of neuronal CCK are incompletely understood. To identify genes regulated by neuronal CCK, we generated neuronal PC12 cells stably expressing the CCK-2 receptor (CCK-2R) and treated the cells with sulphated CCK-8 for 2-16 h, before the global expression profile was examined. The changes in gene expression...... peaked after 2 h, with 67 differentially expressed transcripts identified. A pathway analysis indicated that CCK was implicated in the regulation of the circadian clock system, the plasminogen system and cholesterol metabolism. But transcripts encoding proteins involved in dopamine signaling, ornithine...

  6. Quasi-Chemical PC-SAFT: An Extended Perturbed Chain-Statistical Associating Fluid Theory for Lattice-Fluid Mixtures.

    Science.gov (United States)

    Parvaneh, Khalil; Shariati, Alireza

    2017-09-07

    In this study, a new modification of the perturbed chain-statistical associating fluid theory (PC-SAFT) has been proposed by incorporating the lattice fluid theory of Guggenheim as an additional term to the original PC-SAFT terms. As the proposed model has one more term than the PC-SAFT, a new mixing rule has been developed especially for the new additional term, while for the conventional terms of the PC-SAFT, the one-fluid mixing rule is used. In order to evaluate the proposed model, the vapor-liquid equilibria were estimated for binary CO 2 mixtures with 16 different ionic liquids (ILs) of the 1-alkyl-3-methylimidazolium family with various anions consisting of bis(trifluoromethylsulfonyl) imide, hexafluorophosphate, tetrafluoroborate, and trifluoromethanesulfonate. For a comprehensive comparison, three different modes (different adjustable parameters) of the proposed model were compared with the conventional PC-SAFT. Results indicate that the proposed modification of the PC-SAFT EoS is generally more reliable with respect to the conventional PC-SAFT in all the three proposed modes of vapor-liquid equilibria, giving good agreement with literature data.

  7. Association of nonalcoholic fatty liver disease grades with the plasma cell antigen-1 (PC-1 gene polymorphism

    Directory of Open Access Journals (Sweden)

    Ibrahim H. Borai

    2018-07-01

    Full Text Available Background and aims: Nonalcoholic fatty liver disease (NAFLD is a complicated disease linked with dietary habitats, obesity, and a range of comorbidities correlated with insulin resistance.Although environmental parameters are essential in deciding risk of the disease, proofs from previous reports sustain the hypothesis that genetics are responsible for NAFLD developmentand progression. Plasma cell antigen-1 (PC-1 and its gene polymorphism are associated with NAFLD progression. Consequently, the object of this study was to detect the usefulness of PC-1 K121Q gene polymorphism in NAFLD progression. Subjects and methods: A total of 87 NAFLD patients were included in the study and subdivided ultrasonographically into 31 patients with grade 1 (mild NAFLD, 26 patients with grade 2 (moderate NAFLD and 30 patients with grade 3 (severe NAFLD, in addition to 47 normal controls. The detection of PC-1 K121Q gene polymorphism was accomplished by using restriction fragment length polymorphism (RFLP-PCR. Results: Lipid profile parameters were associated with the incidence of NAFLD. AlthoughPC-1 gene polymorphism didnot significantly change in parallel with NAFLD grades, PC-1 at the genetic and protein level was significantly associated with triacylglycerollevels in NAFLD patients. Conclusion: Lipid profile indices are risk factors for the incidence of NAFLD. Triacylglycerol (TAG level is the hall-mark in the NAFLD pathogenesis and in the predisposition of PC-1 gene polymorphism. Keywords: NAFLD, Triacylglycerol (TAG, Plasma cell antigen-1 (PC-1

  8. PC-3 prostate carcinoma cells release signal substances that influence the migratory activity of cells in the tumor's microenvironment

    Directory of Open Access Journals (Sweden)

    Zänker Kurt S

    2010-07-01

    Full Text Available Abstract Background Tumor cells interact with the cells of the microenvironment not only by cell-cell-contacts but also by the release of signal substances. These substances are known to induce tumor vascularization, especially under hypoxic conditions, but are also supposed to provoke other processes such as tumor innervation and inflammatory conditions. Inflammation is mediated by two organ systems, the neuroendocrine system and the immune system. Therefore, we investigated the influence of substances released by PC-3 human prostate carcinoma cells on SH-SY5Y neuroblastoma cells as well as neutrophil granulocytes and cytotoxic T lymphocytes, especially with regard to their migratory activity. Results PC-3 cells express several cytokines and growth factors including vascular endothelial growth factors, fibroblast growth factors, interleukins and neurotrophic factors. SH-SY5Y cells are impaired in their migratory activity by PC-3 cell culture supernatant, but orientate chemotactically towards the source. Neutrophil granulocytes increase their locomotory activity only in response to cell culture supernantant of hypoxic but not of normoxic PC-3 cells. In contrast, cytotoxic T lymphocytes do not change their migratory activity in response to either culture supernatant, but increase their cytotoxicity, whereas supernatant of normoxic PC-3 cells leads to a stronger increase than that of hypoxic PC-3 cells. Conclusions PC-3 cells release several signal substances that influence the behavior of the cells in the tumor's microenvironment, whereas no clear pattern towards proinflammatory or immunosuppressive conditions can be seen.

  9. Usefulness of 2D PC MRA of the circle of willis in the evaluation of acute cerebral infarction

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Oh Han; Lee, Jae Hee; Kim, Ki Ju; Lee, Sung Yong [Our Lady of Mercy Hospital, Seoul (Korea, Republic of); Choi, Kyu Ho [The Catholic Univ. of Korea, Seoul (Korea, Republic of)

    1999-11-01

    To evaluate the usefulness of axial 2-D PC MRA of the circle of Willis in the evaluation of acute cerebral infarction We evaluated 42 patients with acute cerebral infarction who had undergone T2-weighted and diffusion weighted MR imaging (T2WI, DWI) and 2-D PC MRA of the circle of Willis within 72 hours of the onset of symptoms. In conjunction with high-signal lesions on DWI, the findings of 2-D PC MRA were classified as normal, stenotic, or indicative of arterial occlusion;negative 2-D PC MRA was not considered useful. In addition, the signal intensity of T2WI and DWI was compared. (The findings of 2-D PC MRA showed that 15 cases(35.7%) were normal, 13(31%) were stenotic, and that in 14 (33.3%), occlusion was present). Thus, 2-D PC MRA detected vascular abnormality in 27 cases(64.3%). On T2WI, six cases (14.3%) showed no signal change and 36(85.7%) showed high signal change. In six cases without signal change, MR images were obtained within 12 hours of ictus;in one of these patients MRA findings were normal, one had stenosis, and in four, occlusion was noted. 2-D PC MRA is a useful modality for the detection of vascular abnormality in patients with acute cerebral infarct.

  10. Site-dependent charge transfer at the Pt(111)-ZnPc interface and the effect of iodine

    International Nuclear Information System (INIS)

    Ahmadi, Sareh; Wojek, Bastian M.; Noël, Quentin; Göthelid, Mats; Agnarsson, Björn; Bidermane, Ieva; Sun, Chenghua

    2014-01-01

    The electronic structure of ZnPc, from sub-monolayers to thick films, on bare and iodated Pt(111) is studied by means of X-ray photoelectron spectroscopy, X-ray absorption spectroscopy, and scanning tunneling microscopy. Our results suggest that at low coverage ZnPc lies almost parallel to the Pt(111) substrate, in a non-planar configuration induced by Zn-Pt attraction, leading to an inhomogeneous charge distribution within the molecule and an inhomogeneous charge transfer to the molecule. ZnPc does not form a complete monolayer on the Pt surface, due to a surface-mediated intermolecular repulsion. At higher coverage ZnPc adopts a tilted geometry, due to a reduced molecule-substrate interaction. Our photoemission results illustrate that ZnPc is practically decoupled from Pt, already from the second layer. Pre-deposition of iodine on Pt hinders the Zn-Pt attraction, leading to a non-distorted first layer ZnPc in contact with Pt(111)-I(√3×√3) or Pt(111)-I(√7×√7), and a more homogeneous charge distribution and charge transfer at the interface. On increased ZnPc thickness iodine is dissolved in the organic film where it acts as an electron acceptor dopant

  11. Organic light-emitting diodes with F16CuPC as an efficient hole-injection layer

    International Nuclear Information System (INIS)

    Lee, H. K.; Shin, Y. C.; Kwon, D. S.; Lee, C. H.

    2006-01-01

    We report a new hole-injection material, copper hexadecafluorophthalocyanine (F 16 CuPC) for organic light-emitting diodes (OLEDs) consisting of N,N'-di(1-naphthyl)-N,N'-diphenylbenzidine (α-NPD) as a hole-transport layer and 8-tris-hydroxyquinoline aluminum (Alq 3 ) as a light-emitting and electron-transport layer. The insertion of the F 16 CuPC between indium-tin oxide (ITO) and α-NPD reduces the operating voltage significantly and thereby increases the luminous efficiency. By measuring the device characteristics for various F 16 CuPC thicknesses, we find that an optimum F 16 CuPC thickness is about 15 nm. At a luminance of 1000 cd/m 2 , the device with 15-nm-thick F 16 CuPC shows a luminous efficiency of 1.5 lm/W and a device operating voltage of 7.2 V while the device without the F 16 CuPC layer shows 1.1 lm/W and 10.4 V. The significant decrease in a driving voltage and increase in the luminous efficiency can be attributed to the high hole-injection efficiency when F 16 CuPC is inserted between ITO and α-NPD.

  12. Cocaine- and amphetamine-regulated transcript (CART) peptide specific binding in pheochromocytoma cells PC12

    Czech Academy of Sciences Publication Activity Database

    Maletínská, Lenka; Maixnerová, Jana; Matyšková, Resha; Haugvicová, Renata; Šloncová, Eva; Elbert, Tomáš; Slaninová, Jiřina; Železná, Blanka

    2007-01-01

    Roč. 559, 2/3 (2007), s. 109-114 ISSN 0014-2999 R&D Projects: GA ČR GA303/05/0614 Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50520514; CEZ:AV0Z50200510 Keywords : radioligand binding * CART * PC12 cells * food intake Subject RIV: CE - Biochemistry Impact factor: 2.376, year: 2007

  13. Peptid CART (cocaine- and amphetamine- regulated transcript) v signalizaci buněk PC12

    Czech Academy of Sciences Publication Activity Database

    Nagelová, Veronika; Železná, Blanka; Maletínská, Lenka

    2014-01-01

    Roč. 108, č. 5 (2014), s. 543 ISSN 0009-2770. [Mezioborové setkání mladých biologů, biochemiků a chemiků /14./. 13.05.2014-16.05.2014, Milovy] R&D Projects: GA ČR GAP303/10/1368 Institutional support: RVO:61388963 Keywords : peptide CART * PC12 * c-Jun * SAPK/JNK Subject RIV: CE - Biochemistry

  14. General specifications for the development of a PC-based simulator of the NASA RECON system

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Triantafyllopoulos, Spiros

    1984-01-01

    The general specifications for the design and implementation of an IBM PC/XT-based simulator of the NASA RECON system, including record designs, file structure designs, command language analysis, program design issues, error recovery considerations, and usage monitoring facilities are discussed. Once implemented, such a simulator will be utilized to evaluate the effectiveness of simulated information system access in addition to actual system usage as part of the total educational programs being developed within the NASA contract.

  15. Energetic particle counterparts for geomagnetic pulsations of Pc1 and IPDP types

    Directory of Open Access Journals (Sweden)

    T. A. Yahnina

    Full Text Available Using the low-altitude NOAA satellite particle data, we study two kinds of localised variations of energetic proton fluxes at low altitude within the anisotropic zone equatorward of the isotropy boundary. These flux variation types have a common feature, i.e. the presence of precipitating protons measured by the MEPED instrument at energies more than 30 keV, but they are distinguished by the fact of the presence or absence of the lower-energy component as measured by the TED detector on board the NOAA satellite. The localised proton precipitating without a low-energy component occurs mostly in the morning-day sector, during quiet geomagnetic conditions, without substorm injections at geosynchronous orbit, and without any signatures of plasmaspheric plasma expansion to the geosynchronous distance. This precipitation pattern closely correlates with ground-based observations of continuous narrow-band Pc1 pulsations in the frequency range 0.1–2 Hz (hereafter Pc1. The precipitation pattern containing the low energy component occurs mostly in the evening sector, under disturbed geomagnetic conditions, and in association with energetic proton injections and significant increases of cold plasma density at geosynchronous orbit. This precipitation pattern is associated with geomagnetic pulsations called Intervals of Pulsations with Diminishing Periods (IPDP, but some minor part of the events is also related to narrow-band Pc1. Both Pc1 and IPDP pulsations are believed to be the electromagnetic ion-cyclotron waves generated by the ion-cyclotron instability in the equatorial plane. These waves scatter energetic protons in pitch angles, so we conclude that the precipitation patterns studied here are the particle counterparts of the ion-cyclotron waves.

    Key words. Ionosphere (particle precipitation – Magnetospheric physics (energetic particles, precipitating – Space plasma physics (wave-particle interactions

  16. Energetic particle counterparts for geomagnetic pulsations of Pc1 and IPDP types

    Directory of Open Access Journals (Sweden)

    T. A. Yahnina

    2003-12-01

    Full Text Available Using the low-altitude NOAA satellite particle data, we study two kinds of localised variations of energetic proton fluxes at low altitude within the anisotropic zone equatorward of the isotropy boundary. These flux variation types have a common feature, i.e. the presence of precipitating protons measured by the MEPED instrument at energies more than 30 keV, but they are distinguished by the fact of the presence or absence of the lower-energy component as measured by the TED detector on board the NOAA satellite. The localised proton precipitating without a low-energy component occurs mostly in the morning-day sector, during quiet geomagnetic conditions, without substorm injections at geosynchronous orbit, and without any signatures of plasmaspheric plasma expansion to the geosynchronous distance. This precipitation pattern closely correlates with ground-based observations of continuous narrow-band Pc1 pulsations in the frequency range 0.1–2 Hz (hereafter Pc1. The precipitation pattern containing the low energy component occurs mostly in the evening sector, under disturbed geomagnetic conditions, and in association with energetic proton injections and significant increases of cold plasma density at geosynchronous orbit. This precipitation pattern is associated with geomagnetic pulsations called Intervals of Pulsations with Diminishing Periods (IPDP, but some minor part of the events is also related to narrow-band Pc1. Both Pc1 and IPDP pulsations are believed to be the electromagnetic ion-cyclotron waves generated by the ion-cyclotron instability in the equatorial plane. These waves scatter energetic protons in pitch angles, so we conclude that the precipitation patterns studied here are the particle counterparts of the ion-cyclotron waves.Key words. Ionosphere (particle precipitation – Magnetospheric physics (energetic particles, precipitating – Space plasma physics (wave-particle interactions

  17. Delivery and installation of PC/FRAM at the PNC Tokai Works

    International Nuclear Information System (INIS)

    Sampson, T.E.; Kelley, T.A.; Kroncke, K.E.; Menlove, H.O.; Baca, J.; Asano, Takashi; Terakado, Shigeru; Goto, Yasushi; Kogawa, Noboru

    1997-11-01

    The authors report on the assembly, testing, delivery, installation, and initial testing of three PC/FRAM plutonium isotopic analysis systems at the Power Reactor and Nuclear Fuel Development Corporation's Tokai Works. These systems are intended to measure the isotopic composition and 235 U/plutonium of mixed oxide (MOX) waste in 200-L waste drums. These systems provide capability for performing measurements on lead-lined drums

  18. TOWARD A SPECTROSCOPIC CENSUS OF WHITE DWARFS WITHIN 40 pc OF THE SUN

    International Nuclear Information System (INIS)

    Limoges, M.-M.; Bergeron, P.; Lépine, S.

    2013-01-01

    We present the preliminary results of a survey aimed at significantly increasing the range and completeness of the local census of spectroscopically confirmed white dwarfs. The current census of nearby white dwarfs is reasonably complete only to about 20 pc of the Sun, a volume that includes around 130 white dwarfs, a sample too small for detailed statistical analyses. This census is largely based on follow-up investigations of stars with very large proper motions. We describe here the basis of a method that will lead to a catalog of white dwarfs within 40 pc of the Sun and north of the celestial equator, thus increasing by a factor of eight the extent of the northern sky census. White dwarf candidates are identified from the SUPERBLINK proper motion database, allowing us to investigate stars down to a proper motion limit μ > 40 mas yr –1 , while minimizing the kinematic bias for nearby objects. The selection criteria and distance estimates are based on a combination of color-magnitude and reduced proper motion diagrams. Our follow-up spectroscopic observation campaign has so far uncovered 193 new white dwarfs, among which we identify 127 DA (including 9 DA+dM and 4 magnetic), 1 DB, 56 DC, 3 DQ, and 6 DZ stars. We perform a spectroscopic analysis on a subsample of 84 DAs, and provide their atmospheric parameters. In particular, we identify 11 new white dwarfs with spectroscopic distances within 25 pc of the Sun, including five candidates to the D < 20 pc subset.

  19. Dasatinib inhibits both osteoclast activation and prostate cancer PC-3 cell-induced osteoclast formation

    Science.gov (United States)

    Araujo, John C.; Poblenz, Ann; Corn, Paul G.; Parikh, Nila U.; Starbuck, Michael W.; Thompson, Jerry T.; Lee, Francis; Logothetis, Christopher J.; Darnay, Bryant G.

    2013-01-01

    Purpose Therapies to target prostate cancer bone metastases have only limited effects. New treatments are focused on the interaction between cancer cells, bone marrow cells and the bone matrix. Osteoclasts play an important role in the development of bone tumors caused by prostate cancer. Since Src kinase has been shown to be necessary for osteoclast function, we hypothesized that dasatinib, a Src family kinase inhibitor, would reduce osteoclast activity and prostate cancer (PC-3) cell-induced osteoclast formation. Results Dasatinib inhibited RANKL-induced osteoclast differentiation of bone marrow-derived monocytes with an EC50 of 7.5 nM. PC-3 cells, a human prostate cancer cell line, were able to differentiate RAW 264.7 cells, a murine monocytic cell line, into osteoclasts and dasatinib inhibited this differentiation. In addition, conditioned medium from PC-3 cell cultures was able to differentiate RAW 264.7 cells into osteoclasts and this too, was inhibited by dasatinib. Even the lowest concentration of dasatinib, 1.25 nmol, inhibited osteoclast differentiation by 29%. Moreover, dasatinib inhibited osteoclast activity by 58% as measured by collagen 1 release. Experimental design We performed in vitro experiments utilizing the Src family kinase inhibitor dasatinib to target osteoclast activation as a means of inhibiting prostate cancer bone metastases. Conclusion Dasatinib inhibits osteoclast differentiation of mouse primary bone marrow-derived monocytes and PC-3 cell-induced osteoclast differentiation. Dasatinib also inhibits osteoclast degradation activity. Inhibiting osteoclast differentiation and activity may be an effective targeted therapy in patients with prostate cancer bone metastases. PMID:19855158

  20. The new ENSDF search system NESSY: IBM/PC nuclear spectroscopy database

    International Nuclear Information System (INIS)

    Boboshin, I.N.; Varlamov, V.V.

    1996-01-01

    The universal relational nuclear structure and decay database NESSY (New ENSDF Search SYstem) developed for the IBM/PC and compatible PCs, and based on the international file ENSDF (Evaluated Nuclear Structure Data File), is described. The NESSY provides the possibility of high efficiency processing (the search and retrieval of any kind of physical data) of the information from ENSDF. The principles of the database development are described and examples of applications are presented. (orig.)

  1. The calibration of Andersen Mark-II and California measurements PC-2 QCM cascade impactors

    International Nuclear Information System (INIS)

    Horton, K.D.; Mitchell, J.P.

    1990-05-01

    Andersen Mark-II and California Measurements PC-2 quartz-crystal (QCM) cascade impactors have been calibrated with monodisperse aerosol particles. Both the Andersen and QCM impactors were determined to be reliable instruments: the advantage of the QCM impactor is that real-time monitoring of aerosol behaviour is possible, using short measurement times. However, care is needed to interpret the QCM data if this instrument is used to sample aerosols that carry an unknown or significant electrostatic charge. (author)

  2. ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells

    International Nuclear Information System (INIS)

    Komaragiri, Shravan Kumar; Bostanthirige, Dhanushka H.; Morton, Derrick J.; Patel, Divya; Joshi, Jugal; Upadhyay, Sunil; Chaudhary, Jaideep

    2016-01-01

    Deregulation of tumor suppressor genes is associated with tumorigenesis and the development of cancer. In prostate cancer, ID4 is epigenetically silenced and acts as a tumor suppressor. In normal prostate epithelial cells, ID4 collaborates with androgen receptor (AR) and p53 to exert its tumor suppressor activity. Previous studies have shown that ID4 promotes tumor suppressive function of AR whereas loss of ID4 results in tumor promoter activity of AR. Previous study from our lab showed that ectopic ID4 expression in DU145 attenuates proliferation and promotes AR expression suggesting that ID4 dependent AR activity is tumor suppressive. In this study, we examined the effect of ectopic expression of ID4 on highly malignant prostate cancer cell, PC3. Here we show that stable overexpression of ID4 in PC3 cells leads to increased apoptosis and decreased cell proliferation and migration. In addition, in vivo studies showed a decrease in tumor size and volume of ID4 overexpressing PC3 cells, in nude mice. At the molecular level, these changes were associated with increased androgen receptor (AR), p21, and AR dependent FKBP51 expression. At the mechanistic level, ID4 may regulate the expression or function of AR through specific but yet unknown AR co-regulators that may determine the final outcome of AR function. - Highlights: • ID4 expression induces AR expression in PC3 cells, which generally lack AR. • ID4 expression increased apoptosis and decreased cell proliferation and invasion. • Overexpression of ID4 reduces tumor growth of subcutaneous xenografts in vivo. • ID4 induces p21 and FKBP51 expression- co-factors of AR tumor suppressor activity.

  3. COSYMA, a mainframe and PC program package for assessing the consequences of hypothetical accidents

    International Nuclear Information System (INIS)

    Jones, J.A.; Hasemann, I.; Steen, J. van der

    1996-01-01

    COSYMA (Code System from MARIA) is a program package for assessing the off-site consequences of accidental releases of radioactive material to atmosphere, developed as part of the European Commission's MARIA programme (Methods for Assessing the Radiological Impact of Accidents). COSYMA represents a fusion of ideas and modules from the Forschungszetrum Karlsruhe program system UFOMOD, the National Radiological Protection Board program MARC and new model developments together with data libraries from other MARIA contractors. Mainframe and PC versions of COSYMA are distributed to interested users by arrangement with the European Commission. The system was first released in 1990, and has subsequently been updated. The program system uses independent modules for the different parts of the analysis, and so permits a flexible problem-oriented application to different sites, source terms, emergency plans and the needs of users in the various parts of Europe. Users of the mainframe system can choose the most appropriate combination of modules for their particular application. The PC version includes a user interface which selects the required modules for the endpoints specified by the user. This paper describes the structure of the mainframe and PC versions of COSYMA, and summarises the models included in them. The mainframe or PC versions of COSYMA have been distributed to more than 100 organisations both inside and outside the European Union, and have been used in a wide variety of applications. These range from full PRA level 3 analyses of nuclear power and research reactors to investigations on advanced containment concepts and the preplanning of off-site emergency actions. Some of the experiences from these applications are described in the paper. An international COSYMA user group has been established to stimulate communication between the owners, developers and users of the code and to serve as a reference point for questions relating to the code. The group produces

  4. Protective Effect of Quercetin against Oxidative Stress-Induced Cytotoxicity in Rat Pheochromocytoma (PC-12) Cells

    OpenAIRE

    Dengke Bao; Jingkai Wang; Xiaobin Pang; Hongliang Liu

    2017-01-01

    Oxidative stress has been implicated in the pathogenesis of many kinds of neurodegenerative disorders, particularly Parkinson’s disease. Quercetin is a bioflavonoid found ubiquitously in fruits and vegetables, and has antioxidative activity. However, the underlying mechanism of the antioxidative effect of quercetin in neurodegenerative diseases has not been well explored. Here, we investigated the antioxidative effect and underlying molecular mechanisms of quercetin on PC-12 cells. We found t...

  5. Astroglia overexpressing heme oxygenase-1 predispose co-cultured PC12 cells to oxidative injury.

    Science.gov (United States)

    Song, Linyang; Song, Wei; Schipper, Hyman M

    2007-08-01

    The mechanisms responsible for the progressive degeneration of dopaminergic neurons and pathologic iron deposition in the substantia nigra pars compacta of patients with Parkinson's disease (PD) remain unclear. Heme oxygenase-1 (HO-1), the rate-limiting enzyme in the oxidative degradation of heme to ferrous iron, carbon monoxide, and biliverdin, is upregulated in affected PD astroglia and may contribute to abnormal mitochondrial iron sequestration in these cells. To determine whether glial HO-1 hyper-expression is toxic to neuronal compartments, we co-cultured dopaminergic PC12 cells atop monolayers of human (h) HO-1 transfected, sham-transfected, or non-transfected primary rat astroglia. We observed that PC12 cells grown atop hHO-1 transfected astrocytes, but not the astroglia themselves, were significantly more susceptible to dopamine (1 microM) + H(2)O(2) (1 microM)-induced death (assessed by nuclear ethidium monoazide bromide staining and anti-tyrosine hydroxylase immunofluorescence microscopy) relative to control preparations. In the experimental group, PC12 cell death was attenuated significantly by the administration of the HO inhibitor, SnMP (1.5 microM), the antioxidant, ascorbate (200 microM), or the iron chelators, deferoxamine (400 microM), and phenanthroline (100 microM). Exposure to conditioned media derived from HO-1 transfected astrocytes also augmented PC12 cell killing in response to dopamine (1 microM) + H(2)O(2) (1 microM) relative to control media. In PD brain, overexpression of HO-1 in nigral astroglia and accompanying iron liberation may facilitate the bioactivation of dopamine to neurotoxic free radical intermediates and predispose nearby neuronal constituents to oxidative damage. (c) 2007 Wiley-Liss, Inc.

  6. ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Komaragiri, Shravan Kumar; Bostanthirige, Dhanushka H.; Morton, Derrick J.; Patel, Divya; Joshi, Jugal; Upadhyay, Sunil; Chaudhary, Jaideep, E-mail: jchaudhary@cau.edu

    2016-09-09

    Deregulation of tumor suppressor genes is associated with tumorigenesis and the development of cancer. In prostate cancer, ID4 is epigenetically silenced and acts as a tumor suppressor. In normal prostate epithelial cells, ID4 collaborates with androgen receptor (AR) and p53 to exert its tumor suppressor activity. Previous studies have shown that ID4 promotes tumor suppressive function of AR whereas loss of ID4 results in tumor promoter activity of AR. Previous study from our lab showed that ectopic ID4 expression in DU145 attenuates proliferation and promotes AR expression suggesting that ID4 dependent AR activity is tumor suppressive. In this study, we examined the effect of ectopic expression of ID4 on highly malignant prostate cancer cell, PC3. Here we show that stable overexpression of ID4 in PC3 cells leads to increased apoptosis and decreased cell proliferation and migration. In addition, in vivo studies showed a decrease in tumor size and volume of ID4 overexpressing PC3 cells, in nude mice. At the molecular level, these changes were associated with increased androgen receptor (AR), p21, and AR dependent FKBP51 expression. At the mechanistic level, ID4 may regulate the expression or function of AR through specific but yet unknown AR co-regulators that may determine the final outcome of AR function. - Highlights: • ID4 expression induces AR expression in PC3 cells, which generally lack AR. • ID4 expression increased apoptosis and decreased cell proliferation and invasion. • Overexpression of ID4 reduces tumor growth of subcutaneous xenografts in vivo. • ID4 induces p21 and FKBP51 expression- co-factors of AR tumor suppressor activity.

  7. Correlation of Pc5 wave power inside and outside themagnetosphere during high speed streams

    Directory of Open Access Journals (Sweden)

    R. L. Kessel

    2004-01-01

    Full Text Available We show a clear correlation between the ULF wave power (Pc5 range inside and outside the Earth's magnetosphere during high speed streams in 1995. We trace fluctuations beginning 200RE upstream using Wind data, to fluctuations just upstream from Earth's bow shock and in the magnetosheath using Geotail data and compare to pulsations on the ground at the Kilpisjarvi ground station. With our 5-month data set we draw the following conclusions. ULF fluctuations in the Pc5 range are found in high speed streams; they are non-Alfvénic at the leading edge and Alfvénic in the central region. Compressional and Alfvénic fluctuations are modulated at the bow shock, some features of the waveforms are preserved in the magnetosheath, but overall turbulence and wave power is enhanced by about a factor of 10. Parallel (compressional and perpendicular (transverse power are at comparable levels in the solar wind and magnetosheath, both in the compression region and in the central region of high speed streams. Both the total parallel and perpendicular Pc5 power in the solar wind (and to a lesser extent in the magnetosheath correlate well with the total Pc5 power of the ground-based H-component magnetic field. ULF fluctuations in the magnetosheath during high speed streams are common at frequencies from 1–4mHz and can coincide with the cavity eigenfrequencies of 1.3, 1.9, 2.6, and 3.4mHz, though other discrete frequencies are also often seen.

    Key words. Interplanetary physics (MHD waves and turbulence – Magnetospheric physics (solar wind-magnetosphere interactions; MHD waves and instabilities

  8. Disk cloning program 'Dolly+' for system management of PC Linux cluster

    International Nuclear Information System (INIS)

    Atsushi Manabe

    2001-01-01

    The Dolly+ is a Linux application program to clone files and disk partition image from a PC to many others. By using several techniques such as logical ring connection, multi threading and pipelining, it could achieve high performance and scalability. For example, in typical condition, installations to a hundred PCs takes almost equivalent time for two PCs. Together with the Intel PXE and the RedHat kickstart, automatic and very fast system installation and upgrading could be performed

  9. PC based simulation of gamma camera for training of operating and maintenance staff

    International Nuclear Information System (INIS)

    Singh, B.; Kataria, S.K.; Samuel, A.M.

    2000-01-01

    Gamma camera- a sophisticated imaging system is used for functional assessment of biological subsystems/organs in nuclear medicine. The radioactive tracer attached to the native substance is injected into the patient. The distribution of radioactivity in the patient is imaged by the gamma camera. This report describes a PC based package for simulation of gamma cameras and effect of malfunctioning of its subsystems on images of different phantoms

  10. A predictive group-contribution simplified PC-SAFT equation of state: Application to polymer systems

    DEFF Research Database (Denmark)

    Tihic, Amra; Kontogeorgis, Georgios; von Solms, Nicolas

    2008-01-01

    A group-contribution (GC) method is coupled with the molecular-based perturbed-chain statistical associating fluid theory (PC-SAFT) equation of state (EoS) to predict its characteristic pure compound parameters. The estimation of group contributions for the parameters is based on a parameter...... are the molecular structure of the polymer of interest in terms of functional groups and a single binary interaction parameter for accurate mixture calculations....

  11. Effects of oridonin nanosuspension on cell proliferation and apoptosis of human prostatic carcinoma PC-3 cell line

    Directory of Open Access Journals (Sweden)

    Zhen Zhang

    2010-10-01

    Full Text Available Zhen Zhang, Xiumei Zhang, Wei Xue, Yuna YangYang, Derong Xu, Yunxue Zhao, Haiyan LouSchool of Medicine, Shandong University, Jinan, Republic of ChinaAbstract: This study aims to investigate the inhibitory effects of oridonin nanosuspension on human prostatic carcinoma PC-3 cell line in vitro. The PC-3 cells were incubated with increasing concentrations of oridonin solution and nanosuspensions for 12 hours, 24 hours, and 36 hours. MTT [3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide] assay was performed to measure cellular viability and investigate the effect of oridonin on cell growth of PC-3. Annexin V-FITC/PI staining method was used to determine the effect of oridonin by fluorescence microscope and flow cytometry, respectively. Nanosuspension on early apoptosis of PC-3 cells was also evaluated. Oridonin significantly inhibited the growth of PC-3 cells after 12 hours, 24 hours, and 36 hours of treatment in a dose-dependent manner (P < 0.05. Compared with the same concentration of oridonin solution, oridonin nanosuspension enhanced the inhibition ratio of proliferation. The observation of propidium iodide fluorescence staining confirmed the MTT assay results. The cell proportion of PC-3 at the G2/M phase in the nanosuspension treatment group was upregulated compared with that of the control and oridonin solution groups. Both oridonin solution and nanosuspension promoted the early apoptosis of PC-3 cells. Furthermore, while improving the ratio of early apoptosis, oridonin nanosuspensions also enhanced growth suppression, and induced apoptosis of PC-3 cells. This shows great potential in the treatment of androgen-independent carcinoma of prostate by oridonin nanosuspensions.Keywords: oridonin, nanosuspension, carcinoma of prostate, PC-3 cells, cell cycle, apoptosis

  12. Correlation between serum levels of PC III and the degree of hepatic fibrosis in patients with chronic liver diseases

    International Nuclear Information System (INIS)

    Wang Xue; Xu Yu; Li Wenjie; Zhang Jun; Yu Ying; Wang Kun

    2007-01-01

    Objective: To study the correlation between serum level of PC III and the degree of liver fibrosis in patients with chronic liver diseases. Methods: Serum level of PC III was assayed with RIA and other markers of liver function (including ALT, AST, STB, SDB, TP, ALB, TBA) were assayed with automatic biochemical analyzer in 188 patients with various chronic liver diseases. PC III only were examined in 70 controls. Results: (1) The serum levels of PC III were in this order: chronic severe hepatitis (n=27, 501.17 ± 191.09) > liver cirrhosis from chronic hepatitis (n=27,334.52 ± 139.14) > chronic moderate hepatitis ( n = 32,298.02 ± 151.02) > primary liver cancer (n=39,281.42 ± 143.48) > normal controls (n=70,122.56 ± 92.94). (2) The serum levels of PC III were positively correlated with STB and SDB levels (P<0.05) in patients with chronic severe hepatitis and was significantly positively correlated with ALP levels (P<0.01). (3) The serum level of PC III were significantly positively correlated with STB, SDB, TBA and ALP in patients with cirrhosis from chronic hepatitis (P<0.01). (4) The serum levels of PC III were significantly positively correlated with AST and ALP levels in patients with chronic moderate hepatitis (P<0.01). (5) The serum levels of PC III were significantly positively correlated with STB, SDB, TBA, AST and ALP in patients with primary liver cancer (P<0.01). Conclusion: Serum level of PC III might adequately reflect the activity of the process of hepatic fibrosis, but did not necessarily reflect the degree of fibrosis already attained. (authors)

  13. PC-Link historical data base system MODCOMP/IBM at link for neutral particle beam operation

    International Nuclear Information System (INIS)

    Thurgood, P.

    1989-01-01

    PC-Link is a combination of hardware and software that connects an IBM PC/AT to a MODCOMP minicomputer. It is designed as an aid to the Neutral Beam operations coordinator during injection into the DIII-D tokamak project. An IBM PC/AT is linked to 4 MODCOMP realtime acquisition systems, each of which controls 2 neutral particle beam sources. At various points in the shot sequence, data is sent to the IBM PC/AT. This data can then be integrated with the data from the other sources into tables or graphics displays for use by the Beam Coordinator. In this way, the coordinator gets realtime feedback on the relative settings and performance of the sources and can observe trends within a particular source at one location. The PC-Link is used for observing relative timing information and for post shot historical archiving. The concept of the PC-Link was originally proposed several years ago. In April 1988, in-house implementation of the link software was begun. The PC-Link receives approximately 2 Kbytes of data per source per shot. This data is converted from MODCOMP format to IBM PC format and archived to disk. The last 280 shots per source are stored to disk to observe trends. The data can be displayed in a number of formats depending upon the situation. For example, prior to a shot, the beam MODCOMPs are sent timing information from the DIII-D tokamak control system. This data is echoed on the PC in a graphical representation displaying all 8 sources. At the end of the shot, the actual running times are displayed along with the requested settings. Any subset of the Historical data may be displayed either graphically or in tables for realtime comparisons between sources. 4 figs

  14. PKA activity exacerbates hypoxia-induced ROS formation and hypoxic injury in PC-12 cells.

    Science.gov (United States)

    Gozal, Evelyne; Metz, Cynthia J; Dematteis, Maurice; Sachleben, Leroy R; Schurr, Avital; Rane, Madhavi J

    2017-09-05

    Hypoxia is a primary factor in many pathological conditions. Hypoxic cell death is commonly attributed to metabolic failure and oxidative injury. cAMP-dependent protein kinase A (PKA) is activated in hypoxia and regulates multiple enzymes of the mitochondrial electron transport chain, thus may be implicated in cellular energy depletion and hypoxia-induced cell death. Wild type (WT) PC-12 cells and PKA activity-deficient 123.7 PC-12 cells were exposed to 3, 6, 12 and 24h hypoxia (0.1% or 5% O 2 ). Hypoxia, at 24h 0.1% O 2 , induced cell death and increased reactive oxygen species (ROS) in WT PC-12 cells. Despite lower ATP levels in normoxic 123.7 cells than in WT cells, hypoxia only decreased ATP levels in WT cells. However, menadione-induced oxidative stress similarly affected both cell types. While mitochondrial COX IV expression remained consistently higher in 123.7 cells, hypoxia decreased COX IV expression in both cell types. N-acetyl cysteine antioxidant treatment blocked hypoxia-induced WT cell death without preventing ATP depletion. Transient PKA catα expression in 123.7 cells partially restored hypoxia-induced ROS but did not alter ATP levels or COX IV expression. We conclude that PKA signaling contributes to hypoxic injury, by regulating oxidative stress rather than by depleting ATP levels. Therapeutic strategies targeting PKA signaling may improve cellular adaptation and recovery in hypoxic pathologies. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. A Bio-Electro-Fenton System Employing the Composite FePc/CNT/SS316 Cathode

    Directory of Open Access Journals (Sweden)

    Yi-Ta Wang

    2017-02-01

    Full Text Available Bio-electro-Fenton microbial fuel cells generate energy through the decomposition of organic matter by microorganisms. The generated electricity drives a Fenton reaction in a cathode chamber, which can be used for the decolorization of dye wastewater. Most of the previous works added expensive platinum catalyst to improve the electrical property of the system. In this research, aligned carbon nanotubes (CNTs were generated on the surface of SS316 stainless steel by chemical vapor deposition, and an iron phthalocyanine (FePc catalyst was added to fabricate a compound (FePc/CNT/SS316 that was applied to the cathode electrode of the fuel cell system. This was expected to improve the overall electricity generation efficiency and extent of decolorization of the system. The results showed that the maximum current density of the system with the modified electrode was 3206.30 mA/m2, and the maximum power was 726.55 mW/m2, which were increased by 937 and 2594 times, respectively, compared to the current and power densities of a system where only the SS316 stainless steel electrode was used. In addition, the decolorization of RB5 dye reached 84.6% within 12 h. Measurements of the electrical properties of bio-electro-Fenton microbial fuel cells and dye decolorization experiments with the FePc/CNT/SS316 electrode showed good results.

  16. Analysis of Triplet Exciton Loss Pathways in PTB7:PC71BM Bulk Heterojunction Solar Cells

    Science.gov (United States)

    Kraus, Hannes; Heiber, Michael C.; Väth, Stefan; Kern, Julia; Deibel, Carsten; Sperlich, Andreas; Dyakonov, Vladimir

    2016-07-01

    A strategy for increasing the conversion efficiency of organic photovoltaics has been to increase the VOC by tuning the energy levels of donor and acceptor components. However, this opens up a new loss pathway from an interfacial charge transfer state to a triplet exciton (TE) state called electron back transfer (EBT), which is detrimental to device performance. To test this hypothesis, we study triplet formation in the high performing PTB7:PC71BM blend system and determine the impact of the morphology-optimizing additive 1,8-diiodoctane (DIO). Using photoluminescence and spin-sensitive optically detected magnetic resonance (ODMR) measurements at low temperature, we find that TEs form on PC71BM via intersystem crossing from singlet excitons and on PTB7 via EBT mechanism. For DIO blends with smaller fullerene domains, an increased density of PTB7 TEs is observed. The EBT process is found to be significant only at very low temperature. At 300 K, no triplets are detected via ODMR, and electrically detected magnetic resonance on optimized solar cells indicates that TEs are only present on the fullerenes. We conclude that in PTB7:PC71BM devices, TE formation via EBT is impacted by fullerene domain size at low temperature, but at room temperature, EBT does not represent a dominant loss pathway.

  17. Biogenic selenium nanoparticles induce ROS-mediated necroptosis in PC-3 cancer cells through TNF activation.

    Science.gov (United States)

    Sonkusre, Praveen; Cameotra, Swaranjit Singh

    2017-06-07

    Selenium is well documented to inhibit cancer at higher doses; however, the mechanism behind this inhibition varies widely depending on the cell type and selenium species. Previously, we have demonstrated that Bacillus licheniformis JS2 derived biogenic selenium nanoparticles (SeNPs) induce non-apoptotic cell death in prostate adenocarcinoma cell line, PC-3, at a minimal concentration of 2 µg Se/ml, without causing toxicity to the primary cells. However, the mechanism behind its anticancer activity was elusive. Our results have shown that these SeNPs at a concentration of 2 µg Se/ml were able to induce reactive oxygen species (ROS) mediated necroptosis in PC-3 cells by gaining cellular internalization. Real-time qPCR analysis showed increased expression of necroptosis associated tumor necrotic factor (TNF) and interferon regulatory factor 1 (IRF1). An increased expression of RIP1 protein was also observed at the translational level upon SeNP treatment. Moreover, the cell viability was significantly increased in the presence of necroptosis inhibitor, Necrostatin-1. Data suggest that our biogenic SeNPs induce cell death in PC-3 cells by the ROS-mediated activation of necroptosis, independent to RIP3 and MLKL, regulated by a RIP1 kinase.

  18. Audiovisual Presentations on a Handheld PC are Preferred As an Educational Tool by NICU Parents.

    Science.gov (United States)

    Alur, P; Cirelli, J; Goodstein, M; Bell, T; Liss, J

    2010-01-01

    Health literacy is critical for understanding complex medical problems and necessary for the well being of the patient. Printed educational materials (PM) have limitations in explaining the dynamics of a disease process. Multimedia formats may be useful for enhancing the educational process. To evaluate whether a printed format or animation with commentary on a handheld personal computer (PC) is preferred as an educational tool by parents of a baby in the NICU. PARENTS EVALUATED TWO FORMATS: A 1-page illustrated document from the American Heart Association explaining patent ductus arteriosus (PDA) and animation with commentary on a handheld PC that explained the physiology of PDA in 1 minute. The reading grade level of the PM was 8.6 versus 18.6 for the audio portion of the animated presentation. Parents viewed each format and completed a four-item questionnaire. Parents rated both formats and indicated their preference as printed, animation, or both. Forty-six parents participated in the survey. Parents preferred animation over PM (50% vs. 17.4%. p = 0.02); 39.1% expressed that the animation was excellent; whereas 4.3% expressed that the PM was excellent (p0.05). Parents preferred animation on a small screen handheld PC despite a much higher language level. Because handheld PCs are portable and inexpensive, they can be used effectively at the bedside with low-cost animation to enhance understanding of complex disease conditions.

  19. Aqueous PCDTBT:PC71 BM Photovoltaic Inks Made by Nanoprecipitation.

    Science.gov (United States)

    Prunet, Geoffrey; Parrenin, Laurie; Pavlopoulou, Eleni; Pecastaings, Gilles; Brochon, Cyril; Hadziioannou, Georges; Cloutet, Eric

    2018-01-01

    The fabrication of organic solar cells from aqueous dispersions of photoactive nanoparticles has recently attracted the interest of the photovoltaic community, since these dispersions offer an eco-friendly solution for the fabrication of solar cells, avoiding the use of toxic solvents. In this work, aqueous dispersions of pure poly[n-9'-heptadecanyl-2,7-carbazole-alt-5,5-(4',7'-di-2-thienyl-2',1',3'-benzothiadiazole)] (PCDTBT) and [6,6]-phenyl-C 71 -butyric acid methyl ester (PC 71 BM) nanoparticles, as well as of composite PC 71 BM:PCDTBT nanoparticles, are prepared using the nanoprecipitation postpolymerization method. These dispersions are subsequently used to form the active layer of organic photovoltaic cells. Thin films of PC 71 BM and PCDTBT are obtained by spray deposition of the nanoparticles' dispersions, and are characterized using a combination of spectroscopic and microscopic techniques. Photovoltaics that incorporate these active layers are fabricated thereafter. The impact of the annealing temperature and of the composition of the active layer on the efficiency of the solar cells is studied. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Development of an Adaptive Forecasting System: A Case Study of a PC Manufacturer in South Korea

    Directory of Open Access Journals (Sweden)

    Chihyun Jung

    2016-03-01

    Full Text Available We present a case study of the development of an adaptive forecasting system for a leading personal computer (PC manufacturer in South Korea. It is widely accepted that demand forecasting for products with short product life cycles (PLCs is difficult, and the PLC of a PC is generally very short. The firm has various types of products, and the volatile demand patterns differ by product. Moreover, we found that different departments have different requirements when it comes to the accuracy, point-of-time and range of the forecasts. We divide the demand forecasting process into three stages depending on the requirements and purposes. The systematic forecasting process is then introduced to improve the accuracy of demand forecasting and to meet the department-specific requirements. Moreover, a newly devised short-term forecasting method is presented, which utilizes the long-term forecasting results of the preceding stages. We evaluate our systematic forecasting methods based on actual sales data from the PC manufacturer, where our forecasting methods have been implemented.