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Sample records for cylindrical lead target

  1. Interaction of Explosive Shocks with Airborne Cylindrical Targets of Elliptical

    Directory of Open Access Journals (Sweden)

    V.P. Singh

    1990-07-01

    Full Text Available A theoretical model to find pressure-space history around a cylindrical target of elliptical cross-section has been presented for assessing the damage by warheads exploding in the vicinity of an airborne vehicle. The energy hypothesis has been used to find the attenuation law from a point explosion. The Whitham-Bryson and Gross theory for shock interaction has been modified to take into account the finite strength of incident shock. The theoretical results have also been compared with Heilig's experimental results.

  2. Optoacoustic sensing for target detection inside cylindrical catheters

    Science.gov (United States)

    Tavakoli, Behnoosh; Guo, Xiaoyu; Taylor, Russell H.; Kang, Jin U.; Boctor, Emad M.

    2014-03-01

    Optoacoustic sensing is a hybrid technique that combines the advantages of high sensing depth of ultrasound with contrast of optical absorption. In this study a miniature optoacoustic probe that can characterize the target properties located at the distal end of a catheter is investigated. The probe includes an optical fiber to illuminate the target with the pulsed laser light and a hydrophone to detect the generated optoacoustic signal. The probe is designed for the forwardsensing and therefore the acoustic signal propagates along the tube before being detected. Due to the circular geometry, the waves inside the tube are highly complex. A three dimensional numerical simulation is performed to model the optoacoustic wave generation and propagation inside the water filled cylindrical tubes. The effect of the boundary condition, tube diameter and target size on the detected signal is systematically evaluated. A prototype of the probe is made and tested for detecting an absorbing target inside a 2mm diameter tube submerged in water. The preliminary experimental results corresponding to the simulation is acquired. Although many different medical applications for this miniature probe may exist, our main focus is on detecting the occlusion inside the ventricular shunts. These catheters are used to divert the excess cerebrospinal fluid to the absorption site and regulate inter cranial pressure of hydrocephalous patients. Unfortunately the malfunction rate of these catheters due to blockage is very high. This sensing tool could locate the occluding tissue non-invasively and can potentially characterize the occlusion composites by scanning at different wavelengths of the light.

  3. Accurate Tooth Lead Crowning without Twist in Cylindrical Helical Gear Grinding

    OpenAIRE

    Zhang, Hu; Fang, Chenggang; Huang, XiaoDiao

    2014-01-01

    Form grinding is a popular finishing process in manufacturing cylindrical gears with tooth flank modification. The tooth flanks are usually twisted when a lead crowning is performed only through additional radial motion during double flank grinding. For solving the problem, this paper proposes a method for application of tooth lead crowning without twist in cylindrical helical gears based on the idea of tooth form correction for spiral bevel and hypoid gears. In this method, the motion of eac...

  4. Target engagement in lead generation.

    Science.gov (United States)

    Durham, Timothy B; Blanco, Maria-Jesus

    2015-03-01

    The pharmaceutical industry is currently facing multiple challenges, in particular the low number of new drug approvals in spite of the high level of R&D investment. In order to improve target selection and assess properly the clinical hypothesis, it is important to start building an integrated drug discovery approach during Lead Generation. This should include special emphasis on evaluating target engagement in the target tissue and linking preclinical to clinical readouts. In this review, we would like to illustrate several strategies and technologies for assessing target engagement and the value of its application to medicinal chemistry efforts.

  5. Fabrication and performance of a single-crystal lead magnesium niobate-lead titanate cylindrical hydrophone.

    Science.gov (United States)

    Brown, Jeremy A; Dunphy, Kevin; Leadbetter, Jeff R; Adamson, Robert B A; Beslin, Olivier

    2013-08-01

    The development of a piezoelectric hydrophone based on lead magnesium niobate-lead titanate [PbMg1/3Nb2/3O3-PbTiO3 (PMN-PT)] single-crystal piezoelectric as the hydrophone substrate is reported. Although PMN-PT can possess much higher piezoelectric sensitivity than traditional lead zirconate titanate (PZT) piezoelectrics, it is highly anisotropic and therefore there is a large gain in sensitivity only when the crystal structure is oriented in a specific direction. Because of this, simply replacing the PZT substrate with a PMN-PT cylinder is not an optimal solution because the crystal orientation does not uniformly align with the circumferential axis of the hydrophone. Therefore, a composite hydrophone that maintains the optimal crystal axis around the hydrophone circumference has been developed. An 11.3 mm diameter composite hydrophone cylinder was fabricated from a single cut PMN-PT rectangular plate. Solid end caps were applied to the cylinder and the sensitivity was directly compared with a solid PZT-5A cylindrical hydrophone of equal dimensions in a hydrophone test tank. The charge sensitivity showed a 9.1 dB improvement over the PZT hydrophone and the voltage sensitivity showed a 3.5 dB improvement. This was in good agreement with the expected theoretical improvements of 10.1 and 4.5 dB, respectively.

  6. Cylindrical target Li-beam-driven hohlraum experiments

    Energy Technology Data Exchange (ETDEWEB)

    Derzon, M.S.; Aubert, J.; Chandler, G.A. [and others

    1998-06-01

    The authors performed a series of experiments on the Particle Beam Fusion Accelerator II (PBFA II) in May, 1994, and obtained a brightness temperature of 61 {+-} 2 eV for an ion-beam heated hohlraum. The hohlraum was a 4-mm-diameter, right-circular cylinder with a 1.5-mm-thick gold wall, a low-density CH foam fill, and a 1.5- or 3-mm-diameter diagnostic aperture in the top. The nominal parameters of the radially-incident PBFA II Li ion beam were 9 MeV peak energy ({approximately}10 MeV at the gas cell) at the target at a peak power of 2.5 {+-} 0.3 TW/cm{sup 2} and a 15 ns pulse width. Azimuthal variations in intensity of a factor of 3, with respect to the mean, were observed. Nonuniformities in thermal x-ray emission across the area of the diagnostic hole were also observed. Time-dependent hole-closure velocities were measured: the time-averaged velocity of {approximately}2 cm/{micro}s is in good agreement with sound speed estimates. Unfolded x-ray spectra and brightness temperatures as a function of time are reported and compared to simulations. Hole closure corrections are discussed with comparisons between XRD and bolometer measurements. Temperature scaling with power on target is also presented.

  7. Comparison of large-angle production of charged pions with incident protons on cylindrical long and short targets

    CERN Document Server

    Apollonio, M.; Bagulya, A.; Barr, G.; Blondel, A.; Bobisut, F.; Bogomilov, M.; Bonesini, M.; Booth, C.; Borghi, S.; Bunyatov, S.; Burguet-Castell, J.; Catanesi, M.G.; Cervera-Villanueva, A.; Chimenti, P.; Coney, L.; Di Capua, E.; Dore, U.; Dumarchez, J.; Edgecock, R.; Ellis, M.; Ferri, F.; Gastaldi, U.; Giani, S.; Giannini, G.; Gibin, D.; Gilardoni, S.; Gorbunov, P.; Gossling, C.; Gomez-Cadenas, J.J.; Grant, A.; Graulich, J.S.; Gregoire, G.; Grichine, V.; Grossheim, A.; Guglielmi, A.; Howlett, L.; Ivanchenko, A.; Ivanchenko, V.; Kayis-Topaksu, A.; Kirsanov, M.; Kolev, D.; Krasnoperov, A.; Martin-Albo, J.; Meurer, C.; Mezzetto, M.; Mills, G.B.; Morone, M.C.; Novella, P.; Orestano, D.; Palladino, V.; Panman, J.; Papadopoulos, I.; Pastore, F.; Piperov, Stefan; Polukhina, N.; Popov, B.; Prior, G.; Radicioni, E.; Schmitz, D.; Schroeter, R.; Skoro, G; Sorel, M.; Tcherniaev, E.; Temnikov, P.; Tereschenko, V.; Tonazzo, A.; Tortora, L.; Tsenov, R.; Tsukerman, I.; Vidal-Sitjes, G.; Wiebusch, C.; Zucchelli, P.

    2009-01-01

    The HARP collaboration has presented measurements of the double-differential pi+/pi- production cross-section in the range of momentum 100 MeV/c <= p 800 MeV/c and angle 0.35 rad <= theta <= 2.15 rad with proton beams hitting thin nuclear targets. In many applications the extrapolation to long targets is necessary. In this paper the analysis of data taken with long (one interaction length) solid cylindrical targets made of carbon, tantalum and lead is presented. The data were taken with the large acceptance HARP detector in the T9 beam line of the CERN PS. The secondary pions were produced by beams of protons with momenta 5 GeV/c, 8 GeV/c and 12 GeV/c. The tracking and identification of the produced particles were performed using a small-radius cylindrical time projection chamber (TPC) placed inside a solenoidal magnet. Incident protons were identified by an elaborate system of beam detectors. Results are obtained for the double-differential yields per target nucleon d2 sigma / dp dtheta. The measure...

  8. Comparison of large-angle production of charged pions with incident protons on cylindrical long and short targets

    CERN Document Server

    Artamonov, A; Barr, G; Blondel, A; Bobisut, F; Bogomilov, M; Bonesini, M; Booth, C; Borghi, S; Bunyatov, S; Burguet-Castell, J; Catanesi, M G; Cervera-Villanueva, A; Chimenti, P; Coney, L; Di Capua, E; Dore, U; Dumarchez, J; Edgecock, R; Ellis, M; Ferri, F; Gastaldi, U; Giani, S; Giannini, G; Gibin, D; Gilardoni, S; Gorbunov, P; Gößling, C; Gómez-Cadenas, J J; Grant, A; Graulich, J S; Grégoire, G; Grichine, V; Grossheim, A; Guglielmi, A; Howlett, L; Ivanchenko, A; Ivanchenko, V; Kayis-Topaksu, A; Kirsanov, M; Kolev, D; Krasnoperov, A; MartíinAlbo, J; Meurer, C; Mezzetto, M; B Mills, G; Morone, M C; Novella, P; Orestano, D; Palladino, V; Panman, J; Papadopoulos, I; Pastore, F; Piperov, S; Polukhina, N; Popov, B; Prior, G; Radicioni, E; Schmitz, D; Schroeter, R; Skoro, G; Sorel, M; Tcherniaev, E; Temnikov, P; Tereschenko, V; Tonazzo, A; Tortora, L; Tsenov, R; Tsukerman, I; Vidal-Sitjes, G; Wiebusch, C; Zucchelli, P

    2009-01-01

    The HARP collaboration has presented measurements of the double-differential pi+/pi- production cross-section in the range of momentum 100 MeV/c <= p 800 MeV/c and angle 0.35 rad <= theta <= 2.15 rad with proton beams hitting thin nuclear targets. In many applications the extrapolation to long targets is necessary. In this paper the analysis of data taken with long (one interaction length) solid cylindrical targets made of carbon, tantalum and lead is presented. The data were taken with the large acceptance HARP detector in the T9 beam line of the CERN PS. The secondary pions were produced by beams of protons with momenta 5 GeV/c, 8 GeV/c and 12 GeV/c. The tracking and identification of the produced particles were performed using a small-radius cylindrical time projection chamber (TPC) placed inside a solenoidal magnet. Incident protons were identified by an elaborate system of beam detectors. Results are obtained for the double-differential yields per target nucleon d2 sigma / dp dtheta. The measure...

  9. Fabrication technology for a series of cylindrical thin-wall cavity targets

    CERN Document Server

    Zheng Yong; Sun Zu Oke; Wang Ming Da; Zhou La; Zhou Zhi Yun

    2002-01-01

    Cylindrical thin-wall cavity targets have been fabricated to study the behavior of superthermal electrons and their effects on inertial confinement fusion (ICF). Self-supporting cavity targets having adjustable, uniform wall thickness, and low surface roughness were required. This required production of high-quality mandrels, coating them by sputtering or electroplating, developing techniques for measurement of wall thickness and other cavity parameters, improving the uniformity of rotation of the mandrels, and preventing damage to the targets during removal from the mandrels. Details of the fabrication process are presented. Experimental results from the use of these targets are presented. These results, in good agreement with simulations, indicate that the use of thin-wall cavity targets is an effective method for studying superthermal electrons in ICF.

  10. Magneto-Rayleigh-Taylor Instability: Theory and simulation in planar and cylindrical pulsed power targets

    Science.gov (United States)

    Weis, Matthew R.

    Cylindrical liner implosions in the Magnetized Liner Inertial Fusion (MagLIF) concept are susceptible to the magneto-Rayleigh-Taylor instability (MRT). The danger of MRT enters in two phases, (1) during the main implosion, the outer surface of the liner is MRT unstable, and (2) during the short time period when the liner decelerates onto hot fuel, the inner surface becomes unstable. Growth of MRT on the outer surface may also feedthrough, which may seed the inner surface leading to high MRT growth in the second phase. If MRT growth becomes large enough, confinement of the fuel is lost. To characterize MRT we solve the linearized, ideal MHD equations in both planar and cylindrical geometries, including the presence of an axial magnetic field and the effects of sausage and kink modes (present in cylindrical coordinates only). In general, the total instability growth rates in cylindrical geometry are found to be larger than those in planar geometry. MRT and feedthrough is shown to be suppressed by strong magnetic field line bending (tension). However, for the same amount of field line bending, feedthrough is the most stabilized. Application of the planar and the cylindrical model to results from the Z-machine at Sandia National Laboratories is presented. Analytic MRT growth rates for a typical magnetized MagLIF-like implosion show the kink mode to be the fastest growing early and very late in the liner implosion (during deceleration). 1D HYDRA MHD simulations are used to generate realistic, evolving profiles (in density, pressure, and magnetic field) during the implosion from which instantaneous growth rates can be computed exactly, using either the planar or cylindrical analytic formulae developed in this thesis. Sophisticated 2D HYDRA MHD simulations were also performed to compare with the analytic theory and experimental results. In 2D, highly compressed axial magnetic fields can reduce the growth of perturbations at the fuel/liner interface during the implosion

  11. Influence of high-intensity turbulence on laminar boundary layer development on a cylindrical leading edge: Enhancement to eddy diffusivity

    Science.gov (United States)

    Pearson, Juli K.

    The growing demand for increased efficiency in turbine engine designs has sparked a growing interest for research of air flow around curved surfaces. The turbine's operating conditions result in material property constraints, especially in the first stage turbine vanes and blades. These turbine vane components experience extreme loading conditions of both high temperature and high turbulence intensities exiting the combustor. The surface of the turbine blades has cylindrical leading edges that promote stabilizing flow accelerations. These convex surfaces can cause a reduced eddy diffusivity across the boundary layer. This thesis reviews measurements of velocity and turbulence intensities taken just shy of the thirty degrees offset from the stagnation line of a two-dimensional cylindrical leading edge under a wide range of turbulence and flow conditions flow conditions. Flow conditions and velocity measurements were gathered with respect to the distance to the surface. The length of the measurements extended from the surface to beyond the boundary layer's edge. The instrumentation used to collect data was a single wire driven by a constant temperature anemometer bridge. The hot wire is specially modified to measure data near the cylindrical leading edges curved surface. The traversing system allowed the acquisition of high-resolution boundary layer data. The traversing system was installed internally to the cylindrical leading edge to reduce probe blockage.

  12. Target design for the cylindrical compression of matter driven by heavy ion beams

    Energy Technology Data Exchange (ETDEWEB)

    Piriz, A.R. [E. T. S. I. Industriales, Universidad de Castilla-La Mancha, 13071 Ciudad Real (Spain)]. E-mail: roberto.piriz@uclm.es; Temporal, M. [E. T. S. I. Industriales, Universidad de Castilla-La Mancha, 13071 Ciudad Real (Spain); Lopez Cela, J.J. [E. T. S. I. Industriales, Universidad de Castilla-La Mancha, 13071 Ciudad Real (Spain); Grandjouan, N. [LULI, UMR 7605, Ecole Polytechnique-CNRS-CEA-Universite Paris VI, Palaiseau (France); Tahir, N.A. [GSI Darmstadt, Plankstrasse 1, 64291 Darmstadt (Germany); Serna Moreno, M.C. [E. T. S. I. Industriales, Universidad de Castilla-La Mancha, 13071 Ciudad Real (Spain); Portugues, R.F. [E. T. S. I. Industriales, Universidad de Castilla-La Mancha, 13071 Ciudad Real (Spain); Hoffmann, D.H.H. [GSI Darmstadt, Plankstrasse 1, 64291 Darmstadt (Germany)

    2005-05-21

    The compression of a cylindrical sample of hydrogen contained in a hollow shell of Pb or Au has been analyzed in the framework of the experiments to be performed in the heavy ion synchrotron SIS100 to be constructed at the Gesellschaft fuer Schwerionenforschung (GSI) Darmstadt. The target implosion is driven by an intense beam of heavy ions with a ring-shaped focal spot. We report the results of a parametric study of the final state of the compressed hydrogen in terms of the target and beam parameters. We consider the generation of the annular heated region by means of a radio-frequency wobbler that rotates the beam at extremely high frequencies in order to accommodate symmetry constraints. We have also studied the hydrogen conditions that can be achieved with a non-rotating beam with Gaussian focal spot and the possibility to use a beam stopper as an alternative way to avoid the direct heating of the sample. Finally, we report the analysis of the hydrodynamic instabilities that affect the implosion and the mitigating effects of the elastoplastic properties of the shell.

  13. A physics-based solver to optimize the illumination of cylindrical targets in spherically distributed high power laser systems

    Science.gov (United States)

    Gourdain, P.-A.

    2017-05-01

    In recent years, our understanding of high energy density plasmas has played an important role in improving inertial fusion confinement and in emerging new fields of physics, such as laboratory astrophysics. Every new idea required developing innovative experimental platforms at high power laser facilities, such as OMEGA or NIF. These facilities, designed to focus all their beams onto spherical targets or hohlraum windows, are now required to shine them on more complex targets. While the pointing on planar geometries is relatively straightforward, it becomes problematic for cylindrical targets or target with more complex geometries. This publication describes how the distribution of laser beams on a cylindrical target can be done simply by using a set of physical laws as a pointing procedure. The advantage of the method is threefold. First, it is straightforward, requiring no mathematical enterprise besides solving ordinary differential equations. Second, it will converge if a local optimum exists. Finally, it is computationally inexpensive. Experimental results show that this approach produces a geometrical beam distribution that yields cylindrically symmetric implosions.

  14. A physics-based solver to optimize the illumination of cylindrical targets in spherically distributed high power laser systems.

    Science.gov (United States)

    Gourdain, P-A

    2017-05-01

    In recent years, our understanding of high energy density plasmas has played an important role in improving inertial fusion confinement and in emerging new fields of physics, such as laboratory astrophysics. Every new idea required developing innovative experimental platforms at high power laser facilities, such as OMEGA or NIF. These facilities, designed to focus all their beams onto spherical targets or hohlraum windows, are now required to shine them on more complex targets. While the pointing on planar geometries is relatively straightforward, it becomes problematic for cylindrical targets or target with more complex geometries. This publication describes how the distribution of laser beams on a cylindrical target can be done simply by using a set of physical laws as a pointing procedure. The advantage of the method is threefold. First, it is straightforward, requiring no mathematical enterprise besides solving ordinary differential equations. Second, it will converge if a local optimum exists. Finally, it is computationally inexpensive. Experimental results show that this approach produces a geometrical beam distribution that yields cylindrically symmetric implosions.

  15. Preparation of cylindrical Bi-2223 sintered bulk composed with nickel meshes for current lead

    Energy Technology Data Exchange (ETDEWEB)

    Yoshizawa, S [Department of Environmental Systems, Meisei University, 2-1-1, Hodokubo, Hino, Tokyo 191-8506 (Japan); Sakamoto, M [Department of Electrical Engineering, Kogakuin University, 2665-1, Nakano, Hachioji, Tokyo 192-0015 (Japan); Hishinuma, Y [Fusion Engineering Research Center, National Institute for Fusion Scence, 322-6, Oroshi, Toki, Gifu 509-5202 (Japan); Nishimura, A [Fusion Engineering Research Center, National Institute for Fusion Scence, 322-6, Oroshi, Toki, Gifu 509-5202 (Japan); Yamazaki, S [Department of Electrical Engineering, Kogakuin University, 2665-1, Nakano, Hachioji, Tokyo 192-0015 (Japan); Kojima, S [Department of Electrical Engineering, Kogakuin University, 2665-1, Nakano, Hachioji, Tokyo 192-0015 (Japan)

    2006-06-01

    In order to improve the superconducting property and mechanical property of Bi- 2223 sintered bulk, Ni wire meshes were added in the bulk. The mesh concentration was 18 x 18 meshes/cm{sup 2} using Ni wires of 0.25 mm in diameter. The Ni meshes were plated with Ag by 0.03 mm in thickness. We prepared the cylindrical sintered bulk, 27 mm in outer diameter 2 mm in thickness and 50 mm in length using a cold isostatic pressing (CIP) method. The samples were sintered at 845 deg. C for 50 h. Critical current density (J{sub c}) of the samples was estimated at 77 K under self-field. By composing with the Ni meshes the J{sub c} property was improved compared with the samples without the mesh. It is mentioned that the J{sub c} increase of the Bi-2223 bulk by adding with the Ni meshes is attributed from formation of the Bi-2223 plate-like grains in the vicinity of the Ag-plated Ni wires.

  16. Cylindrical-Wave Approach for Electromagnetic Scattering by Subsurface Targets in a Lossy Medium

    Science.gov (United States)

    Frezza, F.; Pajewski, L.; Ponti, C.; Schettini, G.; Tedeschi, N.

    2012-04-01

    The Cylindrical-Wave Approach (CWA) rigorously solves, in the spectral domain, the electromagnetic forward scattering by a finite set of buried two-dimensional perfectly-conducting or dielectric objects [1]-[3]. In this technique, the field scattered by underground objects is represented in terms of a superposition of cylindrical waves. Use is made of the plane-wave spectrum [1] to take into account the interaction of such waves with the planar interface between air and soil, and between different layers eventually present in the ground. In this work we present the progress we recently made to improve the method. In particular, we have faced the fundamental problem of losses in the ground: this is of significant importance in remote sensing applications, since real soils often have complex permittivity and conductivity, and sometimes also a complex permeability. First, a convergent closed-form representation of the cylindrical-wave angular spectrum in a generic lossy medium has been found [4]. To obtain this spectrum, the canonical Sommerfeld representation of the first-kind Hankel function of integer order has been used; its integration path has been modified to ensure the integral convergence for complex values of the wavenumber. Subsequently, the solution to the scattering problem of a plane-wave propagating in air, impinging on the interface with a dissipative medium, and interacting with a buried perfectly-conducting cylinder, has been derived. The developed method may return the field values in each point of the space, both in the near and far zones; moreover it may be applied for any polarization, and for arbitrary values of the cylinder size and of the distance between the cylinder and the air-soil interface. The theoretical solution has been implemented in a Fortran code. The numerical evaluation of the reflected and transmitted cylindrical wave functions in the presence of lossy media was a critical point: we extended the Gaussian adaptive quadrature

  17. Suppressor T cells - a sensitive target of lead toxicity

    Energy Technology Data Exchange (ETDEWEB)

    Hambach, A.; Stiller-Winkler, R.; Oberbarnscheidt, J.; Ewers, J.

    1983-01-01

    Studies were performed to investigate the effect of chronic low level lead exposure on the regulatory functions of T cells in the humoral immune response to sheep red blood cells (SRBC) in mice. Female mice were exposed to lead (as lead acetate) in the diet at 545 (group 1) and 2180 ppm (group 2) for 10 weeks. Lead exposure resulting in blood lead levels (PbB) of about 50 ..mu..g/100 g (group 1) produced a substantial increase of the number of IgG antibodies secreting spleen cells on days 3 and 4 after challenge. At the higher exposure level (group 2; PbB 60-80 ..mu..g/100 g) a suppression of the number of IgG plaque forming cells was observed. The IgM response was much smaller than the IgG response. Although differences between the group means were small, the results indicate that there also is an enhancement of the IgM response in the lower dosage group on days 3 and 4. In a second experiment the effect of in vivo lead exposure on antigenic competition was examined. Lead substantially reduced the effect of antigenic competition. Results of both experiments suggest that suppressor T cells rather than helper T cells may represent the primary target for lead. Throughout this study serum complement C3 levels were determined. Complement C3 levels tended to be reduced in the lead exposed groups before as well as after inocculation with SRBC. (orig.*.

  18. Suppressor T cells - a sensitive target of lead toxicity

    Energy Technology Data Exchange (ETDEWEB)

    Hambach, A.; Stiller-Winkler, R.; Oberbarnscheidt, J.; Ewers, U.

    1983-01-01

    Studies were performed to investigate the effect of chronic low level lead exposure on the regulatory functions of T cells in the humoral immune response to sheep red blood cells (SRBC) in mice. Female mice were exposed to lead (as lead acetate) in the diet at 545 (group 1) and 2180 ppm (group 2) for 10 weeks. Lead exposure resulting in blood lead levels (PbB) of about 50 ..mu..g/100 g (group 1) produced a substantial increase of the number of IgG antibodies secreting spleen cells on days 3 and 4 after challenge. At the higher exposure level (group 2; PbB 60-80 ..mu..m/100 g) a suppression of the number of IgG plawue forming cells was observed. The IgM response was much smaller than the IgG response. Although differences between the group means were small, the results indicate that there also is an enhancement of the IgM response in the lower dosage group on days 3 and 4. In a second experiment the effect of in vivo lead exposure on antigenic competition was examined. Lead substantially reduced the effect of antigenic competition. Results of both experiments suggest that suppressor T cells rather than helper T cells may represent the primary target for lead. Throughout this study serum complement C3 levels were determined. Complement C3 levels tended to be reduced in the lead exposed groups before as well as after inocculation with SRBC.

  19. Spallation Neutron Spectrum on a Massive Lead/Paraffin Target Irradiated with 1 GeV Protons

    CERN Document Server

    Adam, J; Barashenkov, V S; Brandt, R; Golovatiouk, V M; Kalinnikov, V G; Katovsky, K; Krivopustov, M I; Kumar, V; Kumawat, H; Odoj, R; Pronskikh, V S; Solnyshkin, A A; Stegailov, V I; Tsoupko-Sitnikov, V M; Westmeier, W

    2004-01-01

    The spectra of gamma-ray emitted by decaying residual nuclei, produced by spallation neutrons with (n, xn), (n,xnyp), (n,p), (n,gamma) reactions in activation threshold detectors - namely, ^{209}Bi, ^{197}Au, ^{59}Co, ^{115}In, ^{232}Th, were measured in the Laboratory of Nuclear Problems (LNP), JINR, Dubna, Russia. Spallation neutrons were generated by bombarding a 20 cm long cylindrical lead target, 8 cm in diameter, surrounded by a 6 cm thick layer of paraffin moderator, with a 1 GeV proton beam from the Nuclotron accelerator. Reaction rates and spallation neutron spectrum were measured and compared with CASCADE code calculations.

  20. Pob1 ensures cylindrical cell shape by coupling two distinct rho signaling events during secretory vesicle targeting.

    Science.gov (United States)

    Nakano, Kentaro; Toya, Mika; Yoneda, Aki; Asami, Yukiko; Yamashita, Akira; Kamasawa, Naomi; Osumi, Masako; Yamamoto, Masayuki

    2011-06-01

    Proper cell morphogenesis requires the co-ordination of cell polarity, cytoskeletal organization and vesicle trafficking. The Schizosaccharomyces pombe mutant pob1-664 has a curious lemon-like shape, the basis of which is not understood. Here, we found abundant vesicle accumulation in these cells, suggesting that Pob1 plays a role in vesicle trafficking. We identified Rho3 as a multicopy suppressor of this phenotype. Because Rho3 function is related to For3, an actin-polymerizing protein, and Sec8, a component of the exocyst complex, we analyzed their functional relationship with Pob1. Pob1 was essential for the formation of actin cables (by interacting with For3) and for the polarized localization of Sec8. Although neither For3 nor Sec8 is essential for polarized growth, their simultaneous disruption prevented tip growth and yielded a lemon-like cell morphology similar to pob1-664. Thus, Pob1 may ensure cylindrical cell shape of S. pombe by coupling actin-mediated vesicle transport and exocyst-mediated vesicle tethering during secretory vesicle targeting.

  1. Determination of spallation residues in thin target: toward an hybrid reactor lead target simulation

    Energy Technology Data Exchange (ETDEWEB)

    Audouin, L.; Tassan-Got, L.; Bernas, M.; Rejmund, F.; Stephan, C.; Taieb, J. [Paris-11 Univ., 91- Orsay (France). Inst. de Physique Nucleaire; Enqvist, T.; Armbruster, P.; Ricciardi, M.V.; Schmidt, K.H. [GSI, Planckstrasse 1, Darmstadt (Germany); Boudard, A.; Fernandez, B.; Legrain, R.; Leray, S.; Volant, C.; Wlazlo, W. [CEA Saclay, Dept. d' Astrophysique, de Physique des Particules, de Physique Nucleaire et de l' Instrumentation Associee, 91 - Gif sur Yvette (France); Benlliure, J.; Casajeros, E.; Pereira, J. [University of Santiago de Compostella (Spain); Czajkowski, S. [Centre d' Etudes Nucleaires de Bordeaux Gradignan, CENBG, CNRS-IN2P3, 33 - Gradignan (France)

    2001-07-01

    The production of spallation primary residual nuclei in thin target has been studied by measurement of isotopic yields distributions for several systems. Issues relevant for the design of accelerator-driven systems are presented. Monte-Carlo code abilities to reproduce data are studied in details; it is shown that calculations do not reproduce data in a satisfactory way. Future work orientations leading to an improvement of thin targets calculations and ultimately to a thick target simulation are discussed. (author)

  2. IDMap: facilitating the detection of potential leads with therapeutic targets.

    Science.gov (United States)

    Ha, Soyang; Seo, Young-Ju; Kwon, Min-Seok; Chang, Byung-Ha; Han, Cheol-Kyu; Yoon, Jeong-Hyeok

    2008-06-01

    Pharmaceutical industry has been striving to reduce the costs of drug development and increase productivity. Among the many different attempts, drug repositioning (retargeting existing drugs) comes into the spotlight because of its financial efficiency. We introduce IDMap which predicts novel relationships between targets and chemicals and thus is capable of repositioning the marketed drugs by using text mining and chemical structure information. Also capable of mapping commercial chemicals to possible drug targets and vice versa, IDMap creates convenient environments for identifying the potential lead and its targets, especially in the field of drug repositioning. IDMap executable and its user manual including color images are freely available to non-commercial users at http://www.equispharm.com/idmap

  3. Studies on neutron production in the interaction of 7.4 GeV protons with extended lead target

    CERN Document Server

    Hashemi-Nezhad, S R; Ochs, M; Wan, J S; Schmidt, T; Langrock, E J; Vater, P; Adam, J; Bamblevskij, V P; Bradnova, V; Gelovani, L K; Kalinnikov, V K; Krivopustov, M I; Kulakov, B A; Sosnin, A N; Perelygin, V P; Pronskikh, V S; Stegailov, V I; Tsoupko-Sitnikov, V M; Modolo, G; Odoj, R; Phlippen, P W; Adloff, J C; Debeauvais, M; Zamani-Valassiadou, M; Dwivedi, K K; Wilson, B

    1999-01-01

    A cylindrical lead target of diameter 8 cm and length 20 cm was irradiated with 7.4 GeV protons along the axis of the cylinder. The lead target was surrounded with a paraffin layer of thickness 6 cm to moderate the neutrons produced in p + Pb reactions. The spatial distribution of the slow and fast neutrons on different surfaces of the moderator were determined using LR 115 2B detectors (through sup 1 sup 0 B(n,alpha) sup 7 Li reactions) and CR39 detectors (through proton recoils) respectively. Such results can be valuable in the studies and design of Accelerator Driven Subcritical Nuclear Reactors and Nuclear Waste Incinerators.

  4. Lead-bismuth eutectic recrystallization studies for the Megapie target

    Energy Technology Data Exchange (ETDEWEB)

    Zucchini, A. [ENEA, FIS/MET, Centro Ricerche ' E.Clementel' , via Don Fiammelli 2, 40128 Bologna (Italy); Agostini, P. [ENEA, FIS/ING, Centro Ricerche Brasimone, 40032 Camugnano, Bologna (Italy); Baicchi, E. [ENEA, FIS/ING, Centro Ricerche Brasimone, 40032 Camugnano (Bologna) (Italy)]. E-mail: elio.baicchi@brasimone.enea.it

    2005-02-01

    The expansion behaviour after freezing of the lead-bismuth eutectic (LBE) with 44.5% lead and 55.5% bismuth is described according to the reported theory. The issue of the vessel structural integrity after LBE recrystallization was dealt with by experimental and numerical studies performed in the frame of the Megapie (Megawatt Pilot Experiment) project. We have identified the important elements which, in the case of LBE solidification inside the Megapie target, play a role in the reduction of the possible vessel over-stressing; among them, the LBE yield strength has been tested under significant experimental conditions. The resulting suggestions can also be related to the design and to the freezing procedures for other LBE technology facilities.

  5. 90° Neutron emission from high energy protons and lead ions on a thin lead target

    Science.gov (United States)

    Agosteo, S.; Birattari, C.; Foglio Para, A.; Mitaroff, A.; Silari, M.; Ulrici, L.

    2002-01-01

    The neutron emission from a relatively thin lead target bombarded by beams of high energy protons/pions and lead ions was measured at CERN in one of the secondary beam lines of the Super Proton Synchrotron for radiation protection and shielding calculations. Measurements were performed with three different beams: 208Pb 82+ lead ions at 40 GeV/ c per nucleon and 158 GeV/ c per nucleon, and 40 GeV/ c mixed protons/pions. The neutron yield and spectral fluence per incident ion on target were measured at 90° with respect to beam direction. Monte-Carlo simulations with the FLUKA code were performed for the case of protons and pions and the results found in good agreement with the experimental data. A comparison between simulations and experiment for protons, pions and lead ions have shown that—for such high energy heavy ion beams—a reasonable estimate can be carried out by scaling the result of a Monte-Carlo calculation for protons by the projectile mass number to the power of 0.80-0.84.

  6. 77 FR 16796 - Lead Requirements for Lead-Based Paint Activities in Target Housing and Child-Occupied Facilities...

    Science.gov (United States)

    2012-03-22

    ... AGENCY 40 CFR Part 745 Lead Requirements for Lead-Based Paint Activities in Target Housing and Child... requirements, training program accreditation requirements, and work practice standards for lead-based paint... the Arkansas lead-based paint program and passed a new statute establishing a State lead-based paint...

  7. Lead telluride with increased mechanical stability for cylindrical thermoelectric generators; Bleitellurid mit erhoehter mechanischer Stabilitaet fuer zylindrische thermoelektrische Generatoren

    Energy Technology Data Exchange (ETDEWEB)

    Schmitz, Andreas

    2013-04-30

    The aim of this work is to improve the mechanical stability of lead telluride (PbTe), trying to vary its mechanical properties independently from its thermoelectric properties. Thus the influence of material preparation as well as different dopants on the mechanical and thermoelectric properties of lead telluride is being analysed. When using appropriately set process parameters, milling and sintering of lead telluride increases the material's hardness. With sintering temperatures exceeding 300 C stable material of high relative density can be achieved. Milling lead telluride generates lattice defects leading to a reduction of the material's charge carrier density. These defects can be reduced by increased sintering temperatures. Contamination of the powder due to the milling process leads to bloating during thermal cycling and thus reduced density of the sintered material. In addition to that, evaporation of tellurium at elevated temperatures causes instability of the material's thermoelectric properties. Based on the experimental results obtained in this work, the best thermoelectric and mechanical properties can be obtained by sintering coarse powders at around 400 C. Within this work a concept was developed to vary the mechanical properties of lead telluride via synthesis of PbTe with electrically nondoping elements, which thus may keep the thermoelectric properties unchanged. Therefore, the mechanical and thermoelectric properties of Pb{sub 1-x}Ca{sub x}Te were investigated. Doping pure PbTe with calcium causes a significant increase of the material's hardness while only slightly decreasing the charge carrier density and thus keeping the thermoelectric properties apart from a slight reduction of the electrical conductivity nearly unchanged. The abovementioned concept is proven using sodium doped lead telluride, as it is used for thermoelectric generators: The additional doping with calcium again increases the material's hardness while

  8. Polonium problem in lead-bismuth flow target

    Energy Technology Data Exchange (ETDEWEB)

    Pankratov, D.V.; Yefimov, E.I.; Bugreev, M.I. [State Scientific Centre of Russian Federation-Institute of Physics and Power Engineering, Obninsk (Russian Federation)

    1996-06-01

    Alpha-active polonium nuclides Po198 - Po210 are formed in a lead-bismuth target as results of reactions Bi{sup 209}(n,{gamma})Bi{sup 210} {yields} Po{sup 210}, Bi{sup 209}(p,xn)Po{sup 210} {yields} Po{sup 210 {minus} x} (x = 1-12), Pb{sup 208}({alpha},xn) {yields} Po{sup 210 {minus} x + 2} (x = 2-14). The most important nuclides are Po-210 (T{sub {1/2}}=138.4 day), Po-209 (T{sub {1/2}}=102 years) and Po-208 (T{sub {1/2}}=2.9 years). Polonium activity of the circuit for SINQ - conditions is about 15,000 Ci after 1-year operation. Polonium radiation hazard is connected with its output from the coolant and formation of aerosol and surface alpha-activity after the circuit break-down for repair works or in accidents. One of the important issues of polonium removal system creation is containing and storing polonium removed. Its storage in solidified alkaline is not expedient because of secondary neutron formation as a result of ({alpha},n) - reaction on oxygen and sodium nucleus. The estimations carried out demonstrated that by polonium concentration {approx} 100 Ci/l neutron current on the container surface can reach {approx} 10{sup 4}n/(cm{sup 2}s). Concentration and storage of polonium in solidified lead-bisumth seems the most convenient. The calculations demonstrated that in a 100 l container 50,000 Ci of polonium can be stored (as much as 3 times more than 1-year polonium product in SINQ-conditions) under temperature in the container less than melting point of lead bismuth (the wall temperature is about 100{degrees}C).

  9. Targeting metalloproteins by fragment-based lead discovery.

    Science.gov (United States)

    Johnson, Sherida; Barile, Elisa; Farina, Biancamaria; Purves, Angela; Wei, Jun; Chen, Li-Hsing; Shiryaev, Sergey; Zhang, Ziming; Rodionova, Irina; Agrawal, Arpita; Cohen, Seth M; Osterman, Andrei; Strongin, Alex; Pellecchia, Maurizio

    2011-08-01

    It has been estimated that nearly one-third of functional proteins contain a metal ion. These constitute a wide variety of possible drug targets including metalloproteinases, dehydrogenases, oxidoreductases, hydrolases, deacetylases, or many others in which the metal ion is either of catalytic or of structural nature. Despite the predominant role of a metal ion in so many classes of drug targets, current high-throughput screening techniques do not usually produce viable hits against these proteins, likely due to the lack of proper metal-binding pharmacophores in the current screening libraries. Herein, we describe a novel fragment-based drug discovery approach using a metal-targeting fragment library that is based on a variety of distinct classes of metal-binding groups designed to reliably anchor the fragments at the target's metal ions. We show that the approach can effectively identify novel, potent and selective agents that can be readily developed into metalloprotein-targeted therapeutics.

  10. A magnetic boundary layer creating a quasi-cylindrical substructure within a propagating flux rope leading to a plasma beta transition

    CERN Document Server

    Savani, Neel P; Shiota, D; Linton, M G; Kusano, K; Lugaz, N; Rouillard, A P

    2013-01-01

    We present a 2.5D MHD simulation of a magnetic flux rope (FR) propagating in the heliosphere and investigate the cause of the observed sharp plasma beta transition. Specifically, we consider a strong internal magnetic field and an explosive fast start, such that the plasma beta is significantly lower in the FR than the sheath region that is formed ahead. This leads to an unusual FR morphology in the first stage of propagation, while the more traditional view (e.g. from space weather simulations like Enlil) of a `pancake' shaped FR is observed as it approaches 1 AU. We investigate how an equipartition line, defined by a magnetic Weber number, surrounding a core region of a propagating FR can demarcate a boundary layer where there is a sharp transition in the plasma beta. The substructure affects the distribution of toroidal flux, with the majority of the flux remaining in a small core region which maintains a quasi-cylindrical structure. Quantitatively, we investigate a locus of points where the kinetic energy...

  11. The “curved lead pathway” method to enable a single lead to reach any two intracranial targets

    Science.gov (United States)

    Ding, Chen-Yu; Yu, Liang-Hong; Lin, Yuan-Xiang; Chen, Fan; Lin, Zhang-Ya; Kang, De-Zhi

    2017-01-01

    Deep brain stimulation is an effective way to treat movement disorders, and a powerful research tool for exploring brain functions. This report proposes a “curved lead pathway” method for lead implantation, such that a single lead can reach in sequence to any two intracranial targets. A new type of stereotaxic system for implanting a curved lead to the brain of human/primates was designed, the auxiliary device needed for this method to be used in rat/mouse was fabricated and verified in rat, and the Excel algorithm used for automatically calculating the necessary parameters was implemented. This “curved lead pathway” method of lead implantation may complement the current method, make lead implantation for multiple targets more convenient, and expand the experimental techniques of brain function research.

  12. Factors leading to inflation targeting : The impact of adoption

    NARCIS (Netherlands)

    Samarina, Anna; Sturm, Jan-Egbert

    2013-01-01

    This paper examines how the analysis of inflation targeting (IT) adoption is affected by allowing for a structural change after adoption, using panel probit models for 60 countries over the period 1985-2008. Our findings suggest that there is a structural change after IT adoption. Including the post

  13. Factors leading to inflation targeting - the impact of adoption

    NARCIS (Netherlands)

    Samarina, Anna; Sturm, Jan-Egbert

    2013-01-01

    This paper examines how the analysis of inflation targeting (IT) adoption is affected by the choice of the analyzed period. We test whether country characteristics influence the decision to apply IT differently before and after its adoption, using panel probit models for 60 countries over the period

  14. Factors leading to inflation targeting - the impact of adoption

    NARCIS (Netherlands)

    Samarina, Anna; Sturm, Jan-Egbert

    2013-01-01

    This paper examines how the analysis of inflation targeting (IT) adoption is affected by the choice of the analyzed period. We test whether country characteristics influence the decision to apply IT differently before and after its adoption, using panel probit models for 60 countries over the period

  15. Factors leading to inflation targeting : The impact of adoption

    NARCIS (Netherlands)

    Samarina, Anna; Sturm, Jan-Egbert

    2013-01-01

    This paper examines how the analysis of inflation targeting (IT) adoption is affected by allowing for a structural change after adoption, using panel probit models for 60 countries over the period 1985-2008. Our findings suggest that there is a structural change after IT adoption. Including the

  16. Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy

    NARCIS (Netherlands)

    Clar, Julie; Gri, Blandine; Calderaro, Julien; Birling, Marie-Christine; Herault, Yann; Smit, G. Peter A.; Mithieux, Gilles; Rajas, Fabienne

    2014-01-01

    Renal failure is a major complication that arises with aging in glycogen storage disease type 1a and type 1b patients. In the kidneys, glucose-6 phosphatase catalytic subunit (encoded by G6pc) deficiency leads to the accumulation of glycogen, an effect resulting in marked nephromegaly and

  17. A cylindrical multiwire high-pressure gas proportional chamber surrounding a gaseous $_{2} target with a mylar separation foil $6 \\mu m thick

    CERN Document Server

    Gastaldi, Ugo; Averdung, H; Bailey, J; Beer, G A; Dreher, B; Erdman, K L; Klempt, E; Merle, K; Neubecker, K; Sabev, C; Schwenk, H; Wendling, R D; White, B L; Wodrich, R

    1978-01-01

    The characteristics and performances of a cylindrical multiwire proportional chamber built and used at CERN in experiment S142 for the study of the pp atom spectroscopy are presented. The chamber surrounds a high-pressure gaseous H/sub 2/ target, from which it is separated by a very thin window (6 mu m mylar foil). The active volume (90 cm long; 2 cm thick, internal diameter=30 cm) is divided into 36 equal and independent cells each covering 10 degrees in azimuth. At 4 abs. atm the detection efficiency for X-rays is higher than 20% in the whole energy range 1.5-15 keV. Typical resolutions are 35% fwhm for the 3 ke V Ar fluorescence line and 25% fwhm for the 5.5 keV /sup 54/Mn line. Working pressures from 0.5 to 16 abs. atm have been used. (8 refs).

  18. Therapeutic analysis of high-dose-rate {sup 192}Ir vaginal cuff brachytherapy for endometrial cancer using a cylindrical target volume model and varied cancer cell distributions

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Hualin, E-mail: hualin.zhang@northwestern.edu; Donnelly, Eric D.; Strauss, Jonathan B. [Department of Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, Chicago, Illinois 60611 (United States); Qi, Yujin [Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522 (Australia)

    2016-01-15

    Purpose: To evaluate high-dose-rate (HDR) vaginal cuff brachytherapy (VCBT) in the treatment of endometrial cancer in a cylindrical target volume with either a varied or a constant cancer cell distributions using the linear quadratic (LQ) model. Methods: A Monte Carlo (MC) technique was used to calculate the 3D dose distribution of HDR VCBT over a variety of cylinder diameters and treatment lengths. A treatment planning system (TPS) was used to make plans for the various cylinder diameters, treatment lengths, and prescriptions using the clinical protocol. The dwell times obtained from the TPS were fed into MC. The LQ model was used to evaluate the therapeutic outcome of two brachytherapy regimens prescribed either at 0.5 cm depth (5.5 Gy × 4 fractions) or at the vaginal mucosal surface (8.8 Gy × 4 fractions) for the treatment of endometrial cancer. An experimentally determined endometrial cancer cell distribution, which showed a varied and resembled a half-Gaussian distribution, was used in radiobiology modeling. The equivalent uniform dose (EUD) to cancer cells was calculated for each treatment scenario. The therapeutic ratio (TR) was defined by comparing VCBT with a uniform dose radiotherapy plan in term of normal cell survival at the same level of cancer cell killing. Calculations of clinical impact were run twice assuming two different types of cancer cell density distributions in the cylindrical target volume: (1) a half-Gaussian or (2) a uniform distribution. Results: EUDs were weakly dependent on cylinder size, treatment length, and the prescription depth, but strongly dependent on the cancer cell distribution. TRs were strongly dependent on the cylinder size, treatment length, types of the cancer cell distributions, and the sensitivity of normal tissue. With a half-Gaussian distribution of cancer cells which populated at the vaginal mucosa the most, the EUDs were between 6.9 Gy × 4 and 7.8 Gy × 4, the TRs were in the range from (5.0){sup 4} to (13

  19. Therapeutic analysis of high-dose-rate (192)Ir vaginal cuff brachytherapy for endometrial cancer using a cylindrical target volume model and varied cancer cell distributions.

    Science.gov (United States)

    Zhang, Hualin; Donnelly, Eric D; Strauss, Jonathan B; Qi, Yujin

    2016-01-01

    To evaluate high-dose-rate (HDR) vaginal cuff brachytherapy (VCBT) in the treatment of endometrial cancer in a cylindrical target volume with either a varied or a constant cancer cell distributions using the linear quadratic (LQ) model. A Monte Carlo (MC) technique was used to calculate the 3D dose distribution of HDR VCBT over a variety of cylinder diameters and treatment lengths. A treatment planning system (TPS) was used to make plans for the various cylinder diameters, treatment lengths, and prescriptions using the clinical protocol. The dwell times obtained from the TPS were fed into MC. The LQ model was used to evaluate the therapeutic outcome of two brachytherapy regimens prescribed either at 0.5 cm depth (5.5 Gy × 4 fractions) or at the vaginal mucosal surface (8.8 Gy × 4 fractions) for the treatment of endometrial cancer. An experimentally determined endometrial cancer cell distribution, which showed a varied and resembled a half-Gaussian distribution, was used in radiobiology modeling. The equivalent uniform dose (EUD) to cancer cells was calculated for each treatment scenario. The therapeutic ratio (TR) was defined by comparing VCBT with a uniform dose radiotherapy plan in term of normal cell survival at the same level of cancer cell killing. Calculations of clinical impact were run twice assuming two different types of cancer cell density distributions in the cylindrical target volume: (1) a half-Gaussian or (2) a uniform distribution. EUDs were weakly dependent on cylinder size, treatment length, and the prescription depth, but strongly dependent on the cancer cell distribution. TRs were strongly dependent on the cylinder size, treatment length, types of the cancer cell distributions, and the sensitivity of normal tissue. With a half-Gaussian distribution of cancer cells which populated at the vaginal mucosa the most, the EUDs were between 6.9 Gy × 4 and 7.8 Gy × 4, the TRs were in the range from (5.0)(4) to (13.4)(4) for the radiosensitive normal

  20. Therapeutic analysis of high-dose-rate 192Ir vaginal cuff brachytherapy for endometrial cancer using a cylindrical target volume model and varied cancer cell distributions

    Science.gov (United States)

    Zhang, Hualin; Donnelly, Eric D.; Strauss, Jonathan B.; Qi, Yujin

    2016-01-01

    Purpose: To evaluate high-dose-rate (HDR) vaginal cuff brachytherapy (VCBT) in the treatment of endometrial cancer in a cylindrical target volume with either a varied or a constant cancer cell distributions using the linear quadratic (LQ) model. Methods: A Monte Carlo (MC) technique was used to calculate the 3D dose distribution of HDR VCBT over a variety of cylinder diameters and treatment lengths. A treatment planning system (TPS) was used to make plans for the various cylinder diameters, treatment lengths, and prescriptions using the clinical protocol. The dwell times obtained from the TPS were fed into MC. The LQ model was used to evaluate the therapeutic outcome of two brachytherapy regimens prescribed either at 0.5 cm depth (5.5 Gy × 4 fractions) or at the vaginal mucosal surface (8.8 Gy × 4 fractions) for the treatment of endometrial cancer. An experimentally determined endometrial cancer cell distribution, which showed a varied and resembled a half-Gaussian distribution, was used in radiobiology modeling. The equivalent uniform dose (EUD) to cancer cells was calculated for each treatment scenario. The therapeutic ratio (TR) was defined by comparing VCBT with a uniform dose radiotherapy plan in term of normal cell survival at the same level of cancer cell killing. Calculations of clinical impact were run twice assuming two different types of cancer cell density distributions in the cylindrical target volume: (1) a half-Gaussian or (2) a uniform distribution. Results: EUDs were weakly dependent on cylinder size, treatment length, and the prescription depth, but strongly dependent on the cancer cell distribution. TRs were strongly dependent on the cylinder size, treatment length, types of the cancer cell distributions, and the sensitivity of normal tissue. With a half-Gaussian distribution of cancer cells which populated at the vaginal mucosa the most, the EUDs were between 6.9 Gy × 4 and 7.8 Gy × 4, the TRs were in the range from (5.0)4 to (13.4)4 for the

  1. Filling of charged cylindrical capillaries

    NARCIS (Netherlands)

    Das, Siddhartha; Chanda, Sourayon; Eijkel, J.C.T.; Tas, N.R.; Chakraborty, Suman; Mitra, Sushanta K.

    2014-01-01

    We provide an analytical model to describe the filling dynamics of horizontal cylindrical capillaries having charged walls. The presence of surface charge leads to two distinct effects: It leads to a retarding electrical force on the liquid column and also causes a reduced viscous drag force because

  2. 90 deg.Neutron emission from high energy protons and lead ions on a thin lead target

    CERN Document Server

    Agosteo, S; Foglio-Para, A; Mitaroff, W A; Silari, Marco; Ulrici, L

    2002-01-01

    The neutron emission from a relatively thin lead target bombarded by beams of high energy protons/pions and lead ions was measured at CERN in one of the secondary beam lines of the Super Proton Synchrotron for radiation protection and shielding calculations. Measurements were performed with three different beams: sup 2 sup 0 sup 8 Pb sup 8 sup 2 sup + lead ions at 40 GeV/c per nucleon and 158 GeV/c per nucleon, and 40 GeV/c mixed protons/pions. The neutron yield and spectral fluence per incident ion on target were measured at 90 deg.with respect to beam direction. Monte-Carlo simulations with the FLUKA code were performed for the case of protons and pions and the results found in good agreement with the experimental data. A comparison between simulations and experiment for protons, pions and lead ions have shown that--for such high energy heavy ion beams--a reasonable estimate can be carried out by scaling the result of a Monte-Carlo calculation for protons by the projectile mass number to the power of 0.80-0...

  3. 基于精密测距的红态圆柱钢坯轴心在线检测系统%Research of Hot Cylindrical Billet Axial Lead Position Measurement System Based on Precise Rangefinder

    Institute of Scientific and Technical Information of China (English)

    刘庆运; 朱任之; 景甜甜; 刘涛

    2015-01-01

    红态圆柱钢坯的轴心线相对于模具中心线的偏差对动车组车轮的模压成型具有重要影响。为提高车轮的模压质量和原料成材率,基于高精度激光测距的方法,构建了可用于高温红态圆柱钢坯轴线检测的在线测量系统。首先通过测量位于同一水平截面上的圆柱表面不同4点到相应激光测距传感器的距离,分别得出模具中心线和钢坯轴心线相对于轧机中心线的坐标;然后利用坐标变换方法,计算出钢坯轴心线位置相对于模具中心线的偏差值;最后基于CANopen 协议和通信转换模块构建多传感器检测网络,实现数据的传输与轴心偏差方位的直观显示。通过实际检测实验验证了检测系统与测量算法的有效性。%The position variance of hot cylindrical billet axial lead relative to the mold center line has important influence on the bullet trains compression molding. Based on precise rangefinder,a meas-urement system which used to measuring hot cylindrical billet axial lead was constructed. By measur-ing the distances between the cylindrical billet and laser displacement sensors which fixed on the mill, the coordinates of mold center and the billet axial lead can be determined. According to the coordinate transformation,the position variance of hot cylindrical billet axial lead relative to the mold center line was worked out. Based on CANopen protocol and communication conversion module,the multi-sensor detection network was proposed to realize the data transmission and visual displaying. The practical detection tests were given to illustrate the validity of the algorithm and the reliability of the measure-ment system.

  4. An Airborne Ultrasonic Imaging System Based on 16 Elements: 150 kHz Piezopolymer Transducer Arrays—Preliminary Simulated and Experimental Results for Cylindrical Targets Detection

    Science.gov (United States)

    Capineri, L.; Bulletti, A.; Calzolai, M.; Giannelli, P.

    2016-12-01

    This paper describes the design and fabrication of a 16-element transducer array for airborne ultrasonic imaging operating at 150 kHz, that can operate both at close range (50 mm) in the near field of a synthetic aperture, and up to 250 mm. The proposed imaging technique is based on a modified version of the delay and sum algorithm implemented with a synthetic aperture where each pixel amplitude is determined by the integration of the signal obtained by the coherent summation of the acquired signals over a delayed window with fixed length. The image reconstruction methods using raw data provides the possibility to detect targets with smaller feature size on the order of one wavelength because the coherent signals summation over the selected window length while the image reconstruction methods using the summation of enveloped signals increases the amplitude response at the expenses of a lower spatial resolution. For the implementation of this system it is important to design compact airborne transducers with large field of view and this can be obtained with a new design of hemi-cylindrical polyvinylidene fluoride film transducers directly mounted on a printed circuit board. This new method is low cost and has repeatable transducer characteristics. The complete system is compact, with a modular architecture, in which eight boards with dual ultrasonic channels are mounted on a mother board. Each daughter board hosts a microcontroller unit and can operate with transducers in the bandwidth 40-200 kHz with on-board data acquisition, pre-processing and transfer on a dedicated bus.

  5. Ingestion of cylindrical batteries and its management.

    Science.gov (United States)

    Tien, Tony; Tanwar, Sudeep

    2017-01-17

    In contrast to the ingestion of coin batteries, the ingestion of cylindrical batteries is an uncommon medical presentation. Owing to their larger size, cylindrical battery ingestion can lead to serious complications including intestinal haemorrhage, bowel obstruction, bowel perforation, peritonitis and even death. We discuss the case of a 17-year-old girl who presented after swallowing three cylindrical batteries. Her medical history included depression and previous battery ingestion that required surgical removal. During this presentation however, these ingested batteries were removed endoscopically at oesophagogastroduodenoscopy and ileocolonoscopy. The patient was subsequently discharged without complication. This paper discusses the complications and management of cylindrical battery ingestion. 2017 BMJ Publishing Group Ltd.

  6. Characterization of lead-bismuth eutectic target material for accelerator driven transmuters

    Energy Technology Data Exchange (ETDEWEB)

    Gohar, Yousry E-mail: gohar@anl.gov

    2003-05-15

    Lead-bismuth eutectic (LBE) is under consideration as a target material with high-energy protons for generating neutrons to drive actinide and fission product transmuters. A characterization has been performed to study the performance of this target material as a function of the main variables and the design selections. The characterization includes the neutron yield, the spatial energy deposition, the neutron spectrum, the beam window performance, and the target buffer requirements. The characterization has also considered high-energy deuteron particles to study the impact on the target neutronic performance. The obtained results quantify the LBE target material performance with proton or deuteron particles as a function of the target variables and selections.

  7. Lead

    Science.gov (United States)

    ... found? Who is at risk? What are the health effects of lead? Get educational material about lead Get certified as a Lead Abatement Worker, or other abatement discipline Lead in drinking water Lead air pollution Test your child Check and maintain your home ...

  8. Determination of firing distance. Lead analysis on the target by atomic absorption spectroscopy (AAS).

    Science.gov (United States)

    Gagliano-Candela, Roberto; Colucci, Anna P; Napoli, Salvatore

    2008-03-01

    This paper reports a method for the determination of the firing distance. Atomic absorption spectroscopy (AAS) was used to determine the lead (Pb) pattern around bullet holes produced by shots on test targets from the gun. Test shots were made with a Colt 38 Special at 5, 10, 20, 25, 30, 35, 40, 45, 50, 60, 80, and 100 cm target distance. The target was created with sheets of Whatman no. 1 paper on a polystyrene support. The target was subdivided into three carefully cut out rings (1, 2, and 3; with external diameters of 1.4 cm; 5 cm; 10.2 cm, respectively). Each sample was analyzed with graphite furnace AAS. Lead values analysis performed for each ring yielded a linear relation between the firing distance (cm) and the logarithm of lead amounts (microg/cm(2)) in definite target areas (areas 2 + 3): [ln dPb(2+3) = a(0) + a(1)l]; where dPb(2+3) = lead microg/cm(2) of area 2 + 3; a(0) and a(1) are experimentally calculated; l = distance in cm.

  9. Selection of flowing liquid lead target structural materials for accelerator driven transmutation applications

    Science.gov (United States)

    Park, John J.; Buksa, John J.

    1995-09-01

    The beam entry window and container for a liquid lead spallation target will be exposed to high fluxes of protons and neutrons that are both higher in magnitude and energy than have been experienced in proton accelerators and fission reactors, as well as in a corrosive environment. The structural material of the target should have a good compatibility with liquid lead, a sufficient mechanical strength at elevated temperatures, a good performance under an intense irradiation environment, and a low neutron absorption cross section; these factors have been used to rank the applicability of a wide range of materials for structural containment. Nb-1Zr has been selected for use as the structural container for the LANL ABC/ATW molten lead target. Corrosion and mass transfer behavior for various candidate structural materials in liquid lead are reviewed, together with the beneficial effects of inhibitors and various coatings to protect substrate against liquid lead corrosion. Mechanical properties of some candidate materials at elevated temperatures and the property changes resulting from 800 MeV proton irradiation are also reviewed.

  10. Development of new cylindrical magnetrons for industrial use

    CERN Document Server

    Clayton, B

    2000-01-01

    four-fold system. In an attempt to tackle this problem, a finite element model of the magnetic field generated by the magnetic assembly was built, run and verified. Changes were made to this model, and a new .magnet assembly was built and tested based on the results obtained. This did not lead to a final solution of the problem, but has set bounds within which the solution must lie. A number of alternative techniques were considered and tested with a view to the construction of a cylindrical sputtering device. This device was required to be capable of depositing tribological coatings inside approximately cylindrical substrates of diameters less than 100mm, in an industrial situation. A cylindrical magnetron device was designed, and constructed as a prototype, using a magnetic assembly inside a cylindrical target with outside diameter (o.d.) 40mm. Two alternative magnetic assemblies were tested, and found to have complimentary advantages. The magnetron characteristics of the device were tested, as were key pro...

  11. Momentum measurement by the Multiple Coulomb Scattering method in the OPERA lead emulsion target

    CERN Document Server

    Agafonova, N.; Altinok, O.; Anokhina, A.; Aoki, S.; Ariga, A.; Ariga, T.; Autiero, D.; Badertscher, A.; Bagulya, A.; Ben Dhahbi, A.; Bertolin, A.; Besnier, M.; Bozza, C.; Brugiere, T.; Brugnera, R.; Brunet, F.; Brunetti, G.; Buontempo, S.; Cazes, A.; Chaussard, L.; Chernyavskiy, M.; Chiarella, V.; Chukanov, A.; D'Ambrosio, N.; Dal Corso, F.; De Lellis, G.; del Amo Sanchez, P.; Declais, Y.; De Serio, M.; Di Capua, F.; Di Crescenzo, A.; Di Ferdinando, D.; Di Marco, N.; Dmitrievski, S.; Dracos, M.; Duchesneau, D.; Dusini, S.; Dzhatdoev, T.; Ebert, J.; Egorov, O.; Enikeev, R.; Ereditato, A.; Esposito, L.S.; Favier, J.; Ferber, T.; Fini, R.A.; Frekers, D.; Fukuda, T.; Garfagnini, A.; Giacomelli, G.; Giorgini, M.; Gollnitz, C.; Goldberg, J.; Golubkov, D.; Goncharova, L.; Gornushkin, Y.; Grella, G.; Grianti, F.; Guler, A.M.; Gustavino, C.; Hagner, C.; Hamada, K.; Hara, T.; Hierholzer, M.; Hollnagel, A.; Hoshino, K.; Ieva, M.; Ishida, H.; Jakovcic, K.; Jollet, C.; Juget, F.; Kamiscioglu, M.; Kazuyama, K.; Kim, S.H.; Kimura, M.; Kitagawa, N.; Klicek, B.; Knuesel, J.; Kodama, K.; Komatsu, M.; Kose, U.; Kreslo, I.; Kubota, H.; Lazzaro, C.; Lenkeit, J.; Lippi, I.; Ljubicic, A.; Longhin, A.; Loverre, P.; Lutter, G.; Malgin, A.; Mandrioli, G.; Manai, K.; Marteau, J.; Matsuo, T.; Matveev, V.; Mauri, N.; Medinaceli, E.; Meisel, F.; Meregaglia, A.; Migliozzi, P.; Mikado, S.; Miyamoto, S.; Monacelli, P.; Morishima, K.; Moser, U.; Muciaccia, M.T.; Naganawa, N.; Naka, T.; Nakamura, M.; Nakano, T.; Naumov, D.; Nikitina, V.; Niwa, K.; Nonoyama, Y.; Ogawa, S.; Okateva, N.; Olshevskiy, A.; Paniccia, M.; Paoloni, A.; Park, B.D.; Park, I.G.; Pastore, A.; Patrizii, L.; Pennacchio, E.; Pessard, H.; Pretzl, K.; Pilipenko, V.; Pistillo, C.; Polukhina, N.; Pozzato, M.; Pupilli, F.; Rescigno, R.; Roganova, T.; Rokujo, H.; Romano, G.; Rosa, G.; Rostovtseva, I.; Rubbia, A.; Russo, A.; Ryasny, V.; Ryazhskaya, O.; Sato, O.; Sato, Y.; Schembri, A.; Schmidt-Parzefall, W.; Schroeder, H.; Scotto Lavina, L.; Sheshukov, A.; Shibuya, H.; Shoziyoev, G.; Simone, S.; Sioli, M.; Sirignano, C.; Sirri, G.; Song, J.S.; Spinetti, M.; Stanco, L.; Starkov, N.; Stipcevic, M.; Strauss, T.; Strolin, P.; Takahashi, S.; Tenti, M.; Terranova, F.; Tezuka, I.; Tioukov, V.; Tolun, P.; Trabelsi, A.; Tran, T.; Tufanli, S.; Vilain, P.; Vladimirov, M.; Votano, L.; Vuilleumier, J.L.; Wilquet, G.; Wonsak, B.; Yakushev, V.; Yoon, C.S.; Yoshioka, T.; Yoshida, J.; Zaitsev, Y.; Zemskova, S.; Zghiche, A.; Zimmermann, R.

    2012-01-01

    A new method of momentum measurement of charged particles through Multiple Coulomb Scattering (MCS) in the OPERA lead emulsion target is presented. It is based on precise measurements of track angular deviations performed thanks to the very high resolution of nuclear emulsions. The algorithm has been tested with Monte Carlo (MC) pions. The results are found to describe within the expected uncertainties the data obtained from test beams. We also report a comparison of muon momenta evaluated through MCS in the OPERA lead emulsion target with those determined by the electronic detectors for neutrino charged current interaction events. The two independent measurements agree within the experimental uncertainties, and the results validate the algorithm developed for the emulsion detector of OPERA.

  12. Large-angle scattering of multi-GeV muons on thin Lead targets

    CERN Document Server

    Longhin, A; Pupilli, F

    2015-01-01

    The probability of large-angle scattering for multi-GeV muons in thin ($t/X_0 \\sim 10^{-1}$) lead targets is studied. The new estimates presented here are based both on simulation programs (GEANT4 libraries) and theoretical calculations. In order to validate the results provided by simulation, a comparison is drawn with experimental data from the literature. This study is particularly relevant when applied to muons originating from $\

  13. Present and future contraception: does discovery of targets lead to new contraceptives?

    Science.gov (United States)

    Jensen, Jeffrey T

    2015-01-01

    Although many highly effective methods of reversible contraception are available, high rates of unintended pregnancy and abortion provide evidence that current methods do not meet the needs of all couples. In recent years, a number of highly specific targets have been identified in key pathways that regulate the development of male and female gametes. Support for development of novel approaches has moved from industry to governmental and foundation funders. Continued public funding will be needed to move promising leads into clinical trials.

  14. Quantitative resistance can lead to evolutionary changes in traits not targeted by the resistance QTLs

    Science.gov (United States)

    Van den Berg, Femke; Lannou, Christian; Gilligan, Christopher A; van de Bosch, Frank

    2014-01-01

    This paper addresses the general concern in plant pathology that the introduction of quantitative resistance in the landscape can lead to increased pathogenicity. Hereto, we study the hypothetical case of a quantitative trait loci (QTL) acting on pathogen spore production per unit lesion area. To regain its original fitness, the pathogen can break the QTL, restoring its spore production capacity leading to an increased spore production per lesion. Or alternatively, it can increase its lesion size, also leading to an increased spore production per lesion. A data analysis shows that spore production per lesion (affected by the resistance QTL) and lesion size (not targeted by the QTL) are positively correlated traits, suggesting that a change in magnitude of a trait not targeted by the QTL (lesion size) might indirectly affect the targeted trait (spore production per lesion). Secondly, we model the effect of pathogen adaptation towards increased lesion size and analyse its consequences for spore production per lesion. The model calculations show that when the pathogen is unable to overcome the resistance associated QTL, it may compensate for its reduced fitness by indirect selection for increased pathogenicity on both the resistant and susceptible cultivar, but whereby the QTLs remain effective. PMID:24665339

  15. Quantitative resistance can lead to evolutionary changes in traits not targeted by the resistance QTLs.

    Science.gov (United States)

    Van den Berg, Femke; Lannou, Christian; Gilligan, Christopher A; van de Bosch, Frank

    2014-03-01

    This paper addresses the general concern in plant pathology that the introduction of quantitative resistance in the landscape can lead to increased pathogenicity. Hereto, we study the hypothetical case of a quantitative trait loci (QTL) acting on pathogen spore production per unit lesion area. To regain its original fitness, the pathogen can break the QTL, restoring its spore production capacity leading to an increased spore production per lesion. Or alternatively, it can increase its lesion size, also leading to an increased spore production per lesion. A data analysis shows that spore production per lesion (affected by the resistance QTL) and lesion size (not targeted by the QTL) are positively correlated traits, suggesting that a change in magnitude of a trait not targeted by the QTL (lesion size) might indirectly affect the targeted trait (spore production per lesion). Secondly, we model the effect of pathogen adaptation towards increased lesion size and analyse its consequences for spore production per lesion. The model calculations show that when the pathogen is unable to overcome the resistance associated QTL, it may compensate for its reduced fitness by indirect selection for increased pathogenicity on both the resistant and susceptible cultivar, but whereby the QTLs remain effective.

  16. Lead

    Science.gov (United States)

    ... Chapter 6 Chapter 7 Chapter 8 Chapter 9 Appendix I Appendix II Tables Figures State Programs Alabama Alaska Arizona ... Tool Kit Resources Healthy Homes and Lead Poisoning Prevention Training Center (HHLPPTC) Training Tracks File Formats Help: ...

  17. Multimode interaction in axially excited cylindrical shells

    OpenAIRE

    2014-01-01

    Cylindrical shells exhibit a dense frequency spectrum, especially near the lowest frequency range. In addition, due to the circumferential symmetry, frequencies occur in pairs. So, in the vicinity of the lowest natural frequencies, several equal or nearly equal frequencies may occur, leading to a complex dynamic behavior. So, the aim of the present work is to investigate the dynamic behavior and stability of cylindrical shells under axial forcing with multiple equal or nearly equal natural fr...

  18. Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?

    Institute of Scientific and Technical Information of China (English)

    Christen; L; Walters; Haygood; Rebecca; C; Arend; J; Michael; Straughn; Donald; J; Buchsbaum

    2014-01-01

    Despite significant effort and research funds, epithelial ovarian cancer remains a very deadly disease. There are no effective screening methods that discover early stage disease; the majority of patients are diagnosed with advanced disease. Treatment modalities consist primarily of radical debulking surgery followed by taxane and platinum-based chemotherapy. Newer therapies including limited targeted agents and intraperitoneal delivery of chemotherapeutic drugs have improved disease-free intervals, but failed to yield longlasting cures in most patients. Chemotherapeutic resistance, particularly in the recurrent setting, plagues the disease. Targeting the pathways and mechanisms behind the development of chemoresistance in ovarian cancer could lead to significant improvement in patient outcomes. In many malignancies, including blood and other solid tumors, there is a subgroup of tumor cells, separate from the bulk population, called cancer stem cells(CSCs). These CSCs are thought to be the cause of metastasis, recurrence and resistance. However, todate, ovarian CSCs have been difficult to identify, isolate, and target. It is felt by many investigators that finding a putative ovarian CSC and a chemotherapeutic agent to target it could be the key to a cure for this deadly disease. This review will focus on recent advances in this arena and discuss some of the controversies surrounding the concept.

  19. First protein drug target's appraisal of lead-likeness descriptors to unfold the intervening chemical space.

    Science.gov (United States)

    Athar, Mohd; Lone, Mohsin Y; Jha, Prakash C

    2017-03-01

    Despite the advances in combinatorial chemistry, high throughput and virtual screening experiments, plethora of clinical studies disquiet due to lead and drug-likeness attritions. For mitigation, the knowledge of physicochemical properties are really useful for guiding and selection of compounds from libraries dictated by certain rule of thumbs. However, robust bio-technological and instrumental innovations have created exponential increase in novel compounds and databases which compelled rethinking of the evaluation procedures. Known descriptive molecular property filters proposed by Lipinski, Verber and Hann are not efficient enough to encompass long array of compounds. Moreover, these filters do not take into account the specificity of biological target. In this pursuit, we have tried to appraise eight molecular properties for two major classes of biological targets viz membrane proteins and ion channels binding ligands. These molecular properties were utilized to search for the specific attributes that can be identified as an intervening space for dictating the biological activity.

  20. Neutron production from 158 GeV/c per nucleon lead ions on thin copper and lead targets in the angular range 30-135 degree

    CERN Document Server

    Silari, Marco; Birattari, C; Foglio-Para, A; Gini, L; Mitaroff, Angela; Ulrici, L

    2002-01-01

    The neutron emission from 5, 10 and 20 mm thick lead and 10 and 20 mm thick copper targets bombarded by a lead ion beam with momentum of 158 GeV/c per nucleon were measured at the CERN Super Proton Synchrotron. The neutron yield and spectral fluence per incident ion on target were measured with an extended range Bonner sphere spectrometer in the angular range 30-135 degree with respect to beam direction. Monte Carlo simulations with the FLUKA code were performed to establish a guess spectrum for the unfolding of the experimental data. The results have shown that, lacking Monte Carlo radiation transport codes dealing with ions with masses larger than 1 amu, a reasonable prediction can be carried out by scaling the result of a Monte Carlo calculation for protons by the projectile mass number to the power of 0.85-0.95 for a lead target and 0.88-1.03 for a copper target.

  1. 40 CFR 745.226 - Certification of individuals and firms engaged in lead-based paint activities: target housing and...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Certification of individuals and firms engaged in lead-based paint activities: target housing and child-occupied facilities. 745.226 Section 745... § 745.226 Certification of individuals and firms engaged in lead-based paint activities: target housing...

  2. Cardiac resynchronization therapy: Dire need for targeted left ventricular lead placement and optimal device programming

    Institute of Scientific and Technical Information of China (English)

    Sokratis; Pastromas; Antonis; S; Manolis

    2014-01-01

    Cardiac resynchronization therapy(CRT) effected via biventricular pacing has been established as prime therapy for heart failure patients of New York Heart Association functional class Ⅱ, Ⅲ and ambulatory Ⅳ, reduced left ventricular(LV) function, and a widened QRS complex. CRT has been shown to improve symptoms, LV function, hospitalization rates, and survival. In order to maximize the benefit from CRT and reduce the number of non-responders, consideration should be given to target the optimal site for LV lead implantation away from myocardial scar and close to the latest LV site activation; and also to appropriately program the device paying particular attention to optimal atrioventricular and interventricular intervals. We herein review current data related to both optimal LV lead placement and device programming and their effects on CRT clinical outcomes.

  3. AN ANALYTICAL MODEL FOR PENETRATION INTO CYLINDRICAL METALLIC THICK TARGET BY RIGID SHARP-NOSED PROJECTILES%刚性尖头弹侵彻圆柱形金属厚靶分析模型

    Institute of Scientific and Technical Information of China (English)

    宋殿义; 刘飞; 蒋志刚

    2013-01-01

    考虑金属厚靶侧面自由边界的影响,研究了刚性尖头弹侵彻有限平面尺寸金属厚靶问题.基于有限柱形空腔膨胀理论和线性硬化材料模型,得到了空腔壁径向压力的解析式,建立了刚性尖头弹侵彻有限直径圆柱形金属厚靶工程模型.与试验和数值模拟比较表明,该文工程模型计算精度很好.基于所建立的工程模型,研究了靶板半径对侵彻深度和侵彻阻力的影响,结果表明:当靶板与弹丸半径比值小于20时,靶板半径对侵彻阻力和侵彻深度有显著影响,不能按无限尺寸靶板计算;当靶板与弹丸半径比值大于20时,靶板半径对侵彻阻力和侵彻深度影响较小,可近似按无限尺寸靶计算.%The penetration of thick mental targets with finite planner dimensions by a rigid sharp-nose was investigated in the consideration of the lateral free boundary of the target. Based on the Finite Cylindrical Cavity Expansion (FCCE) theory and the linear strain-hardening material model, analytical solutions of radial pressure on the cavity wall were obtained, and an engineering model for rigid sharp-nosed projectile penetration into cylindrical thick metal targets was presented. The penetration depths from the present model are in a good agreement with those from the published ballistic experiments and numerical simulation. Based on the model, the influence of a target radius on penetration depth and penetration resistance was studied. The results show that the penetration resistance and the penetration depth are obviously affected by the ratio of the target radius to the projectile radius when the ratio is less than 20, they can not be calculated as an unlimited-size target. When the ratio of the target radius to the projectile radius is larger than 20, the target radius has less effects on the penetration depth and penetration resistance, that can be approximately calculated as an unlimited-size target.

  4. OptForce: an optimization procedure for identifying all genetic manipulations leading to targeted overproductions.

    Directory of Open Access Journals (Sweden)

    Sridhar Ranganathan

    2010-04-01

    Full Text Available Computational procedures for predicting metabolic interventions leading to the overproduction of biochemicals in microbial strains are widely in use. However, these methods rely on surrogate biological objectives (e.g., maximize growth rate or minimize metabolic adjustments and do not make use of flux measurements often available for the wild-type strain. In this work, we introduce the OptForce procedure that identifies all possible engineering interventions by classifying reactions in the metabolic model depending upon whether their flux values must increase, decrease or become equal to zero to meet a pre-specified overproduction target. We hierarchically apply this classification rule for pairs, triples, quadruples, etc. of reactions. This leads to the identification of a sufficient and non-redundant set of fluxes that must change (i.e., MUST set to meet a pre-specified overproduction target. Starting with this set we subsequently extract a minimal set of fluxes that must actively be forced through genetic manipulations (i.e., FORCE set to ensure that all fluxes in the network are consistent with the overproduction objective. We demonstrate our OptForce framework for succinate production in Escherichia coli using the most recent in silico E. coli model, iAF1260. The method not only recapitulates existing engineering strategies but also reveals non-intuitive ones that boost succinate production by performing coordinated changes on pathways distant from the last steps of succinate synthesis.

  5. Target hazard quotient evaluation of cadmium and lead in fish from Caspian Sea.

    Science.gov (United States)

    Basim, Yalda; Khoshnood, Zahra

    2016-02-01

    Heavy metals are being increasingly released into the natural waters from geological and anthropogenic sources. The distributions of several heavy metals such as cadmium (Cd) and lead (Pb) were investigated in muscle and liver of three different fish species seasonally collected from Caspian Sea (autumn 2011-summer 2012). The concentrations of all metals were lower in flesh than those recorded in liver due to their physiological roles. The target hazard quotient (THQ) index for fish was calculated. Estimation of THQ calculations for the contaminated fish consumption was calculated to evaluate the effect of pollution on health. Total metal THQ values of Pb and Cd for adults were 0.05 and 0.04 in Anzali and Noshahr, respectively, and for children were 0.08 and 0.05 in Anzali and Noshahr, respectively.

  6. Fragile X and autism: Intertwined at the molecular level leading to targeted treatments.

    Science.gov (United States)

    Hagerman, Randi; Hoem, Gry; Hagerman, Paul

    2010-09-21

    Fragile X syndrome (FXS) is caused by an expanded CGG repeat (> 200 repeats) in the 5' untranslated portion of the fragile mental retardation 1 gene (FMR1), leading to deficiency or absence of the FMR1 protein (FMRP). FMRP is an RNA carrier protein that controls the translation of several other genes that regulate synaptic development and plasticity. Autism occurs in approximately 30% of FXS cases, and pervasive developmental disorder, not otherwise specified (PDD-NOS) occurs in an additional 30% of cases. Premutation repeat expansions (55 to 200 CGG repeats) may also give rise to autism spectrum disorders (ASD), including both autism and PDD-NOS, through a different molecular mechanism that involves a direct toxic effect of the expanded CGG repeat FMR1 mRNA. RNA toxicity can also lead to aging effects including tremor, ataxia and cognitive decline, termed fragile X-associated tremor ataxia syndrome (FXTAS), in premutation carriers in late life. In studies of mice bearing premutation expansions, there is evidence of early postnatal neuronal cell toxicity, presenting as reduced cell longevity, decreased dendritic arborization and altered synaptic morphology. There is also evidence of mitochondrial dysfunction in premutation carriers. Many of the problems with cellular dysregulation in both premutation and full mutation neurons also parallel the cellular abnormalities that have been documented in autism without fragile X mutations. Research regarding dysregulation of neurotransmitter systems in FXS, including the metabotropic glutamate receptor (mGluR)1/5 pathway and γ aminobutyric acid (GABA)A pathways, have led to new targeted treatments for FXS. Preliminary evidence suggests that these new targeted treatments will also be beneficial in non-fragile X forms of autism.

  7. Fragile X and autism: Intertwined at the molecular level leading to targeted treatments

    Directory of Open Access Journals (Sweden)

    Hagerman Randi

    2010-09-01

    Full Text Available Abstract Fragile X syndrome (FXS is caused by an expanded CGG repeat (> 200 repeats in the 5' untranslated portion of the fragile mental retardation 1 gene (FMR1, leading to deficiency or absence of the FMR1 protein (FMRP. FMRP is an RNA carrier protein that controls the translation of several other genes that regulate synaptic development and plasticity. Autism occurs in approximately 30% of FXS cases, and pervasive developmental disorder, not otherwise specified (PDD-NOS occurs in an additional 30% of cases. Premutation repeat expansions (55 to 200 CGG repeats may also give rise to autism spectrum disorders (ASD, including both autism and PDD-NOS, through a different molecular mechanism that involves a direct toxic effect of the expanded CGG repeat FMR1 mRNA. RNA toxicity can also lead to aging effects including tremor, ataxia and cognitive decline, termed fragile X-associated tremor ataxia syndrome (FXTAS, in premutation carriers in late life. In studies of mice bearing premutation expansions, there is evidence of early postnatal neuronal cell toxicity, presenting as reduced cell longevity, decreased dendritic arborization and altered synaptic morphology. There is also evidence of mitochondrial dysfunction in premutation carriers. Many of the problems with cellular dysregulation in both premutation and full mutation neurons also parallel the cellular abnormalities that have been documented in autism without fragile X mutations. Research regarding dysregulation of neurotransmitter systems in FXS, including the metabotropic glutamate receptor (mGluR1/5 pathway and γ aminobutyric acid (GABAA pathways, have led to new targeted treatments for FXS. Preliminary evidence suggests that these new targeted treatments will also be beneficial in non-fragile X forms of autism.

  8. Optimal Dosing for Targeted Therapies in Oncology: Drug Development Cases Leading by Example.

    Science.gov (United States)

    Sachs, Jeffrey R; Mayawala, Kapil; Gadamsetty, Satvik; Kang, Soonmo Peter; de Alwis, Dinesh P

    2016-03-15

    One of the key objectives of oncology first-in-human trials has often been to establish the maximum tolerated dose (MTD). However, targeted therapies might not exhibit dose-limiting toxicities (DLT) at doses significantly higher than sufficiently active doses, and there is frequently a limited ability to objectively quantify adverse events. Thus, while MTD-based determination of recommended phase II dose may have yielded appropriate dosing for some cytotoxics, targeted therapeutics (including monoclonal antibodies and/or immunotherapies) sometimes need alternative or complementary strategies to help identify dose ranges for a randomized dose-ranging study. One complementary strategy is to define a biologically efficacious dose (BED) using an "effect marker." An effect marker could be a target engagement, pharmacodynamic, or disease progression marker (change in tumor size for solid tumors or bone marrow blast count for some hematologic tumors). Although the concept of BED has been discussed extensively, we review specific examples in which the approach influenced oncology clinical development. Data extracted from the literature and the examples support improving dose selection strategies to benefit patients, providers, and the biopharmaceutical industry. Although the examples illustrate key contributions of effect markers in dose selection, no one-size-fits-all approach to dosing can be justified. Higher-than-optimal dosing can increase toxicity in later trials (and in clinical use), which can have a negative impact on efficacy (via lower adherence or direct sequelae of toxicities). Proper dose selection in oncology should follow a multifactorial decision process leading to a randomized, dose-ranging study instead of a single phase II dose. ©2015 American Association for Cancer Research.

  9. Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease.

    Science.gov (United States)

    Bennett, David A; Yu, Lei; De Jager, Philip L

    2014-04-15

    Cognitive decline, Alzheimer's disease (AD) and other causes are major public health problems worldwide. With changing demographics, the number of persons with dementia will increase rapidly. The treatment and prevention of AD and other dementias, therefore, is an urgent unmet need. There have been considerable advances in understanding the biology of many age-related disorders that cause dementia. Gains in understanding AD have led to the development of ante-mortem biomarkers of traditional neuropathology and the conduct of several phase III interventions in the amyloid-β cascade early in the disease process. Many other intervention strategies are in various stages of development. However, efforts to date have met with limited success. A recent National Institute on Aging Research Summit led to a number of requests for applications. One was to establish multi-disciplinary teams of investigators who use systems biology approaches and stem cell technology to identify a new generation of AD targets. We were recently awarded one of three such grants to build a pipeline that integrates epidemiology, systems biology, and stem cell technology to discover and validate novel therapeutic targets and lead compounds for AD treatment and prevention. Here we describe the two cohorts that provide the data and biospecimens being exploited for our pipeline and describe the available unique datasets. Second, we present evidence in support of a chronic disease model of AD that informs our choice of phenotypes as the target outcome. Third, we provide an overview of our approach. Finally, we present the details of our planned drug discovery pipeline. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. Large-angle production of charged pions by 3 GeV/c - 12.9 GeV/c protons on beryllium, aluminium and lead targets

    CERN Document Server

    Catanesi, M.G.; Edgecock, R.; Ellis, Malcolm; Soler, F.J.P.; Gossling, C.; Bunyatov, S.; Krasnoperov, A.; Popov, B.; Serdiouk, V.; Tereschenko, V.; Di Capua, E.; Vidal-Sitjes, G.; Artamonov, A.; Giani, S.; Gilardoni, S.; Gorbunov, P.; Grant, A.; Grossheim, A.; Ivanchenko, V.; Kayis-Topaksu, A.; Panman, J.; Papadopoulos, I.; Tcherniaev, E.; Tsukerman, I.; Veenhof, R.; Wiebusch, C.; Zucchelli, P.; Blondel, A.; Borghi, S.; Morone, M.C.; Prior, G.; Schroeter, R.; Meurer, C.; Gastaldi, U.; Mills, G.B.; Graulich, J.S.; Gregoire, G.; Bonesini, M.; Ferri, F.; Kirsanov, M.; Bagulya, A.; Grichine, V.; Polukhina, N.; Palladino, V.; Coney, L.; Schmitz, D.; Barr, G.; De Santo, A.; Bobisut, F.; Gibin, D.; Guglielmi, A.; Mezzetto, M.; Dumarchez, J.; Dore, U.; Orestano, D.; Pastore, F.; Tonazzo, A.; Tortora, L.; Booth, C.; Howlett, L.; Bogomilov, M.; Chizhov, M.; Kolev, D.; Tsenov, R.; Piperov, Stefan; Temnikov, P.; Apollonio, M.; Chimenti, P.; Giannini, G.; Burguet-Castell, J.; Cervera-Villanueva, A.; Gomez-Cadenas, J.J.; Martin-Albo, J.; Novella, P.; Sorel, M.; CERN. Geneva

    2008-01-01

    Measurements of the double-differential $\\pi^{\\pm}$ production cross-section in the range of momentum $100 \\MeVc \\leq p < 800 \\MeVc$ and angle $0.35 \\rad \\leq \\theta < 2.15 \\rad$ in proton--beryllium, proton--aluminium and proton--lead collisions are presented. The data were taken with the HARP detector in the T9 beam line of the CERN PS. The pions were produced by proton beams in a momentum range from 3 \\GeVc to 12.9 \\GeVc hitting a target with a thickness of 5% of a nuclear interaction length. The tracking and identification of the produced particles was performed using a small-radius cylindrical time projection chamber (TPC) placed inside a solenoidal magnet. Incident particles were identified by an elaborate system of beam detectors. Results are obtained for the double-differential cross-sections at six incident proton beam momenta (3 \\GeVc, 5 \\GeVc, 8 \\GeVc, 8.9 \\GeVc (Be only), 12 \\GeVc and 12.9 \\GeVc (Al only)) and compared to previously available data.

  11. Large-angle production of charged pions by 3 GeV/c - 12.9 GeV/c protons on beryllium, aluminium and lead targets

    CERN Document Server

    Catanesi, M G; Edgecock, R; Ellis, Malcolm; Soler, F J P; Gössling, C; Bunyatov, S; Krasnoperov, A; Popov, B; Serdiouk, V; Tereschenko, V; Di Capua, E; Vidal-Sitjes, G; Artamonov, A; Giani, S; Gilardoni, S; Gorbunov, P; Grant, A; Grossheim, A; Ivanchenko, V; Kayis-Topaksu, A; Panman, J; Papadopoulos, I; Chernyaev, E; Tsukerman, I; Veenhof, R; Wiebusch, C; Zucchelli, P; Blondel, A; Borghi, S; Morone, M C; Prior, G; Schroeter, R; Meurer, C; Gastaldi, U; Mills, G B; Graulich, J S; Grégoire, G; Bonesini, M; Ferri, F; Kirsanov, M; Bagulya, A; Grichine, V; Polukhina, N; Palladino, V; Coney, L; Schmitz, D; Barr, G; De Santo, A; Bobisut, F; Gibin, D; Guglielmi, A; Mezzetto, M; Dumarchez, J; Dore, U; Orestano, D; Pastore, F; Tonazzo, A; Tortora, L; Booth, C; Howlett, L; Bogomilov, M; Chizhov, M; Kolev, D; Tsenov, R; Piperov, Stefan; Temnikov, P; Apollonio, M; Chimenti, P; Giannini, G; Burguet-Castell, J; Cervera-Villanueva, A; Gómez-Cadenas, J J; Martín-Albo, J; Novella, P; Sorel, M; CERN. Geneva

    2008-01-01

    Measurements of the double-differential $\\pi^{\\pm}$ production cross-section in the range of momentum $100 \\MeVc \\leq p < 800 \\MeVc$ and angle $0.35 \\rad \\leq \\theta < 2.15 \\rad$ in proton--beryllium, proton--aluminium and proton--lead collisions are presented. The data were taken with the HARP detector in the T9 beam line of the CERN PS. The pions were produced by proton beams in a momentum range from 3 \\GeVc to 12.9 \\GeVc hitting a target with a thickness of 5% of a nuclear interaction length. The tracking and identification of the produced particles was performed using a small-radius cylindrical time projection chamber (TPC) placed inside a solenoidal magnet. Incident particles were identified by an elaborate system of beam detectors. Results are obtained for the double-differential cross-sections at six incident proton beam momenta (3 \\GeVc, 5 \\GeVc, 8 \\GeVc, 8.9 \\GeVc (Be only), 12 \\GeVc and 12.9 \\GeVc (Al only)) and compared to previously available data.

  12. Targeted inactivation of GPR26 leads to hyperphagia and adiposity by activating AMPK in the hypothalamus.

    Directory of Open Access Journals (Sweden)

    Daohong Chen

    Full Text Available G-protein coupled receptor 26 (GPR26 is a brain-specific orphan GPCR with high expression in the brain region that controls satiety. Depletion of GPR26 has been shown to increase fat storage in C. elegans, whereas GPR26 deficiency in the hypothalamus is associated with high genetic susceptibility to the onset of obesity in mice. However, the metabolic function of GPR26 in mammals remains elusive. Herein, we investigated a role of GPR26 in regulating energy homeostasis by generating mice with targeted deletion of the GPR26 gene. We show that GPR26 deficiency causes hyperphagia and hypometabolism, leading to early onset of diet-induced obesity. Accordingly, GPR26 deficiency also caused metabolic complications commonly associated with obesity, including glucose intolerance, hyperinsulinemia, and dyslipidemia. Moreover, consistent with hyperphagia in GPR26 null mice, GPR26 deficiency significantly increased hypothalamic activity of AMPK, a key signaling event that stimulates appetite. In further support of a regulatory role of GPR26 in satiety, GPR26 knockout mice also demonstrate hypersensitivity to treatment of rimonabant, an endocannabinoid receptor-1 antagonist commonly used to treat obesity by suppressing appetite in humans. Together, these findings identified a key role of GPR26 as a central regulator of energy homeostasis though modulation of hypothalamic AMPK activation.

  13. IdealKnock: A framework for efficiently identifying knockout strategies leading to targeted overproduction.

    Science.gov (United States)

    Gu, Deqing; Zhang, Cheng; Zhou, Shengguo; Wei, Liujing; Hua, Qiang

    2016-04-01

    In recent years, computer aided redesigning methods based on genome-scale metabolic network models (GEMs) have played important roles in metabolic engineering studies; however, most of these methods are hindered by intractable computing times. In particular, methods that predict knockout strategies leading to overproduction of desired biochemical are generally unable to do high level prediction because the computational time will increase exponentially. In this study, we propose a new framework named IdealKnock, which is able to efficiently evaluate potentials of the production for different biochemical in a system by merely knocking out pathways. In addition, it is also capable of searching knockout strategies when combined with the OptKnock or OptGene framework. Furthermore, unlike other methods, IdealKnock suggests a series of mutants with targeted overproduction, which enables researchers to select the one of greatest interest for experimental validation. By testing the overproduction of a large number of native metabolites, IdealKnock showed its advantage in successfully breaking through the limitation of maximum knockout number in reasonable time and suggesting knockout strategies with better performance than other methods. In addition, gene-reaction relationship is well considered in the proposed framework.

  14. Microfabricated cylindrical ion trap

    Science.gov (United States)

    Blain, Matthew G.

    2005-03-22

    A microscale cylindrical ion trap, having an inner radius of order one micron, can be fabricated using surface micromachining techniques and materials known to the integrated circuits manufacturing and microelectromechanical systems industries. Micromachining methods enable batch fabrication, reduced manufacturing costs, dimensional and positional precision, and monolithic integration of massive arrays of ion traps with microscale ion generation and detection devices. Massive arraying enables the microscale cylindrical ion trap to retain the resolution, sensitivity, and mass range advantages necessary for high chemical selectivity. The microscale CIT has a reduced ion mean free path, allowing operation at higher pressures with less expensive and less bulky vacuum pumping system, and with lower battery power than conventional- and miniature-sized ion traps. The reduced electrode voltage enables integration of the microscale cylindrical ion trap with on-chip integrated circuit-based rf operation and detection electronics (i.e., cell phone electronics). Therefore, the full performance advantages of microscale cylindrical ion traps can be realized in truly field portable, handheld microanalysis systems.

  15. Cylindrically Polarized Nondiffracting Optical Pulses

    CERN Document Server

    Ornigotti, Marco; Szameit, Alexander

    2016-01-01

    We extend the concept of radially and azimuthally polarized optical beams to the polychromatic domain by introducing cylindrically polarized nondiffracting optical pulses. In particular, we discuss in detail the case of cylindrically polarized X-waves, both in the paraxial and nonparaxial regime. The explicit expressions for the electric and magnetic fields of cylindrically polarized X-waves is also reported.

  16. A role for fragment-based drug design in developing novel lead compounds for central nervous system targets

    Directory of Open Access Journals (Sweden)

    Michael J. Wasko

    2015-09-01

    Full Text Available Hundreds of millions of U.S. dollars are invested in the research and development of a single drug. Lead compound development is an area ripe for new design strategies. Therapeutic lead candidates have been traditionally found using high-throughput in vitro pharmacologic screening, a costly method for assaying thousands of compounds. This approach has recently been augmented by virtual screening, which employs computer models of the target protein to narrow the search for possible leads. A variant of virtual screening is fragment-based drug design, an emerging in silico lead discovery method that introduces low molecular weight fragments, rather than intact compounds, into the binding pocket of the receptor model. These fragments serve as starting points for growing the lead candidate. Current efforts in virtual fragment-based drug design within central nervous system (CNS targets are reviewed, as is a recent rule-based optimization strategy in which new molecules are generated within a 3D receptor binding pocket using the fragment as a scaffold. This process places special emphasis on creating synthesizable molecules but also exposes computational questions worth addressing. Fragment-based methods provide a viable, relatively low-cost alternative for therapeutic lead discovery and optimization that can be applied to CNS targets to augment current design strategies.

  17. Turbulence in the cylindrical slab

    Energy Technology Data Exchange (ETDEWEB)

    Gentle, K. W.; Rowan, W. L.; Williams, C. B.; Brookman, M. W. [Institute of Fusion Studies, University of Texas at Austin, Austin, Texas 78712 (United States)

    2014-09-15

    The cylindrical slab was the first and simplest model of intrinsically unstable microturbulence. The Helimak is an experimental realization of this model. Although finite, it is sufficiently large to escape boundary effects, with dimensionless parameters similar to those of a tokamak edge or scrape off layer. The essential drive is interchange-like, a pressure gradient with unfavorable magnetic curvature, leading to a non-linearly saturated state of large-amplitude turbulence, Δn{sub rms}/n ∼ 0.5. The nonlinear processes governing this saturation are unique, unlike any of those posited for the much weaker turbulence typical of confined plasma, e.g., in a tokamak. Neither linear stability theory, quasi-linear theory, zonal flows, nor flow shear stabilization is consistent with the observations. The mechanisms determining the non-linearly saturated state constitute an important challenge to our understanding of strongly nonlinear systems.

  18. Adipose tissue: another target organ for lead accumulation? A study on Sardinian children (Italy).

    Science.gov (United States)

    Vallascas, Elisabetta; De Micco, Alessandro; Deiana, Fabrizio; Banni, Sebastiano; Sanna, Emanuele

    2013-01-01

    This study analyzes the relationship between lead levels and adipose tissue in Sardinian children. As an environmental pollutant, lead occurs in two different chemical forms: inorganic and organic lead; organic lead is present in the environment mainly as lead-alkyls (tetramethyl and tetraethyl lead). The lead-alkyls are characterized by their liposolubility; because of this characteristic, the behavior of organic Pb in the organism is similar to that of persistent organic pollutants (POPs). In fact, the high liposolubility of POPs, synthetic chemical substances highly resistant to biodegradation in both the environment and the human body, gives them a preferential tendency to accumulate in adipose tissue. The study sample consisted of 759 children between 11 and 15 years resident in various municipalities of Sardinia. Hair lead levels (PbH) were used as the biomarker of exposure, while several anthropometric indexes were adopted to evaluate the adipose tissue: weight, body mass index, waist circumference, waist to hip circumference ratio, and sum of skinfolds (Σskf). The results of the multivariate ridge regression analysis, controlling for sex and age, show a significant positive relationship between logPbH and logΣskf but not the other adiposity indicators. This results suggests that organic lead tends to accumulate in adipose tissue, although it would be appropriate to measure lead levels in the adipose tissue itself in order to verify the results. Hence this tissue could be considered a possible new biological matrix for the evaluation of environmental lead exposure. Copyright © 2013 Wiley Periodicals, Inc.

  19. Dual-action Hybrid Compounds - A New Dawn in the Discovery of Multi-target Drugs: Lead Generation Approaches.

    Science.gov (United States)

    Abdolmalekia, Azizeh; Ghasemi, Jahan B

    2016-09-27

    Finding high quality beginning compounds is a critical job at the start of the lead generation stage for multi-target drug discovery (MTDD). Designing hybrid compounds as a selective multi-target chemical entity is a challenge, opportunity, and new idea to better act against specific multiple targets. One hybrid molecule is formed by two (or more) pharmacophore group's participation. So, these new compounds often exhibit two or more activities going about as multi-target drugs (mt-drugs) and may have superior safety or efficacy. Application of integrating a range of information and sophisticated new in silico, bioinformatics, structural biology, pharmacogenomics methods may be useful to discover/design, and synthesis of the new hybrid molecules. In this regard, many rational and screening approaches have followed by medicinal chemists for the lead generation in MTDD. Here, we review some popular lead generation approaches that have been used for designing multiple ligands (DMLs). This paper focuses on dual- acting chemical entities that incorporate a part of two drugs or bioactive compounds to compose hybrid molecules. Also, it presents some of key concepts and limitations/strengths of lead generation methods by comparing combination framework method with screening approaches. Besides, a number of examples to represent applications of hybrid molecules in the drug discovery are included.

  20. Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms

    OpenAIRE

    2014-01-01

    Genetic deletion of JAK2 in vivo shows that MPN cells remain fully dependent on JAK2 signaling for survival.Dual JAK2 targeting with JAK and HSP90 inhibitors offers increased efficacy in murine models and primary samples.

  1. Genomes2Drugs: identifies target proteins and lead drugs from proteome data.

    LENUS (Irish Health Repository)

    Toomey, David

    2009-01-01

    BACKGROUND: Genome sequencing and bioinformatics have provided the full hypothetical proteome of many pathogenic organisms. Advances in microarray and mass spectrometry have also yielded large output datasets of possible target proteins\\/genes. However, the challenge remains to identify new targets for drug discovery from this wealth of information. Further analysis includes bioinformatics and\\/or molecular biology tools to validate the findings. This is time consuming and expensive, and could fail to yield novel drugs if protein purification and crystallography is impossible. To pre-empt this, a researcher may want to rapidly filter the output datasets for proteins that show good homology to proteins that have already been structurally characterised or proteins that are already targets for known drugs. Critically, those researchers developing novel antibiotics need to select out the proteins that show close homology to any human proteins, as future inhibitors are likely to cross-react with the host protein, causing off-target toxicity effects later in clinical trials. METHODOLOGY\\/PRINCIPAL FINDINGS: To solve many of these issues, we have developed a free online resource called Genomes2Drugs which ranks sequences to identify proteins that are (i) homologous to previously crystallized proteins or (ii) targets of known drugs, but are (iii) not homologous to human proteins. When tested using the Plasmodium falciparum malarial genome the program correctly enriched the ranked list of proteins with known drug target proteins. CONCLUSIONS\\/SIGNIFICANCE: Genomes2Drugs rapidly identifies proteins that are likely to succeed in drug discovery pipelines. This free online resource helps in the identification of potential drug targets. Importantly, the program further highlights proteins that are likely to be inhibited by FDA-approved drugs. These drugs can then be rapidly moved into Phase IV clinical studies under \\'change-of-application\\' patents.

  2. Genomes2Drugs: identifies target proteins and lead drugs from proteome data.

    Directory of Open Access Journals (Sweden)

    David Toomey

    Full Text Available BACKGROUND: Genome sequencing and bioinformatics have provided the full hypothetical proteome of many pathogenic organisms. Advances in microarray and mass spectrometry have also yielded large output datasets of possible target proteins/genes. However, the challenge remains to identify new targets for drug discovery from this wealth of information. Further analysis includes bioinformatics and/or molecular biology tools to validate the findings. This is time consuming and expensive, and could fail to yield novel drugs if protein purification and crystallography is impossible. To pre-empt this, a researcher may want to rapidly filter the output datasets for proteins that show good homology to proteins that have already been structurally characterised or proteins that are already targets for known drugs. Critically, those researchers developing novel antibiotics need to select out the proteins that show close homology to any human proteins, as future inhibitors are likely to cross-react with the host protein, causing off-target toxicity effects later in clinical trials. METHODOLOGY/PRINCIPAL FINDINGS: To solve many of these issues, we have developed a free online resource called Genomes2Drugs which ranks sequences to identify proteins that are (i homologous to previously crystallized proteins or (ii targets of known drugs, but are (iii not homologous to human proteins. When tested using the Plasmodium falciparum malarial genome the program correctly enriched the ranked list of proteins with known drug target proteins. CONCLUSIONS/SIGNIFICANCE: Genomes2Drugs rapidly identifies proteins that are likely to succeed in drug discovery pipelines. This free online resource helps in the identification of potential drug targets. Importantly, the program further highlights proteins that are likely to be inhibited by FDA-approved drugs. These drugs can then be rapidly moved into Phase IV clinical studies under 'change-of-application' patents.

  3. Quantitative resistance can lead to evolutionary changes in traits not targeted by the resistance QTLs.

    OpenAIRE

    van den Berg, F.; Lannou, C.; Gilligan, CA; Bosch, F.

    2014-01-01

    This paper addresses the general concern in plant pathology that the introduction of quantitative resistance in the landscape can lead to increased pathogenicity. Hereto, we study the hypothetical case of a quantitative trait loci (QTL) acting on pathogen spore production per unit lesion area. To regain its original fitness, the pathogen can break the QTL, restoring its spore production capacity leading to an increased spore production per lesion. Or alternatively, it can increase its lesion ...

  4. Cup Cylindrical Waveguide Antenna

    Science.gov (United States)

    Acosta, Roberto J.; Darby, William G.; Kory, Carol L.; Lambert, Kevin M.; Breen, Daniel P.

    2008-01-01

    The cup cylindrical waveguide antenna (CCWA) is a short backfire microwave antenna capable of simultaneously supporting the transmission or reception of two distinct signals having opposite circular polarizations. Short backfire antennas are widely used in mobile/satellite communications, tracking, telemetry, and wireless local area networks because of their compactness and excellent radiation characteristics. A typical prior short backfire antenna contains a half-wavelength dipole excitation element for linear polarization or crossed half-wavelength dipole elements for circular polarization. In order to achieve simultaneous dual circular polarization, it would be necessary to integrate, into the antenna feed structure, a network of hybrid components, which would introduce significant losses. The CCWA embodies an alternate approach that entails relatively low losses and affords the additional advantage of compactness. The CCWA includes a circular cylindrical cup, a circular disk subreflector, and a circular waveguide that serves as the excitation element. The components that make it possible to obtain simultaneous dual circular polarization are integrated into the circular waveguide. These components are a sixpost polarizer and an orthomode transducer (OMT) with two orthogonal coaxial ports. The overall length of the OMT and polarizer (for the nominal middle design frequency of 2.25 GHz) is about 11 in. (approximately equal to 28 cm), whereas the length of a commercially available OMT and polarizer for the same frequency is about 32 in. (approximately equal to 81 cm).

  5. Influence of Different Moderator Materials on Characteristics of Neutron Fluxes Generated under Irradiation of Lead Target with Proton Beams

    CERN Document Server

    Sosnin, A N; Polanski, A; Petrochenkov, S A; Golovatyuk, V M; Krivopustov, M I; Bamblevski, V P; Westmeier, W; Odoj, R; Brandt, R; Robotham, H; Hashemi-Nezhad, S R; Zamani-Valassiadou, M

    2002-01-01

    Neutron fields generated in extended heavy (Z\\geq 82) targets under irradiation with proton beams at energies in the range of 1 GeV are investigated. Influence of different moderators on the spectra and multiplicities of neutrons escaping the surface of the assembly consisting of a lead target (\\varnothing 8 cm\\times 20 cm or \\varnothing 8cm\\times 50 cm) screened by variable thickness of polyethylene or graphite, respectively, was compared in the present work. It is shown that the effectiveness of graphite as a material used in such assemblies to moderate spallation neutrons down to thermal energies is significantly lower than that of paraffin.

  6. How genetic testing can lead to targeted management of XIAP deficiency-related inflammatory bowel disease

    DEFF Research Database (Denmark)

    Nielsen, Ole Haagen; LaCasse, Eric Charles

    2017-01-01

    X-linked lymphoproliferative disease type 2 (XLP-2, OMIM 300635) is a primary immunodeficiency caused by the loss of X chromosome-linked inhibitor of apoptosis (XIAP), the X-linked inhibitor of apoptosis gene at Xq25. XLP-2 individuals are susceptible to several specific and potentially fatal inf......, and expedite specific targeted therapy.Genet Med advance online publication 14 July 2016Genetics in Medicine (2016); doi:10.1038/gim.2016.82....

  7. Evaluating the 1996 EU food aid reform: Did it really lead to better targeting?

    OpenAIRE

    2009-01-01

    The paper analyses the 1996 EU food aid reform and addresses the question of its impact on improving EU food aid allocation in terms of reaching those countries which are most vulnerable to food insecurity. Using a two-stage regression model the analysis finds that EU food aid in kind is increasingly targeted towards developing countries affected by food insecurity. Most importantly, characteristics such as low calorie supply and balance-of-payments difficulties gained in importance in EU foo...

  8. Current therapeutic leads for the treatment of melanoma: targeted immunotherapy in the post-genomic era.

    Science.gov (United States)

    Papanastasiou, Anastasios D; Sirinian, Chaido; Kalofonos, Haralabos P; Repanti, Maria

    2014-01-01

    Metastatic melanoma has a poor prognosis and until today most therapeutic approaches are ineffective. Advances in molecular pathology and genome analysis technologies have led to the identification of genetic events and immune regulatory checkpoints that provide novel targets for pharmaceutical intervention in melanoma. Development of selective mitogen-activated kinase (MAPK) pathway inhibitors was the first major achievement coming from genetic studies that identified a constitutively active MAP kinase pathway and BRAF activating mutations in melanoma. At the same time, the manipulation of immune system checkpoints through monoclonal antibodies changed clinical practice and led to further improvement of patient outcomes. In an effort to further develop melanoma targeted therapies that depend on the genetic profile of a given patient, high-throughput genome wide approaches (next-generation sequencing [NGS], gene arrays, etc) have been employed for the characterization of genetic alterations in the patient's tumor. In the near future, the combined information from the genetic and immune background of an individual will provide the basis for a personalized, highly targeted approach in the treatment of melanoma.

  9. Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy

    Science.gov (United States)

    Chan, Lai Yue; Craik, David J.; Daly, Norelle L.

    2016-01-01

    Peptide analogues derived from bioactive hormones such as somatostatin or certain growth factors have great potential as angiogenesis inhibitors for cancer applications. In an attempt to combat emerging drug resistance many FDA-approved anti-angiogenesis therapies are co-administered with cytotoxic drugs as a combination therapy to target multiple signaling pathways of cancers. However, cancer therapies often encounter limiting factors such as high toxicities and side effects. Here, we combined two anti-angiogenic epitopes that act on different pathways of angiogenesis into a single non-toxic cyclic peptide framework, namely MCoTI-II (Momordica cochinchinensis trypsin inhibitor-II), and subsequently assessed the anti-angiogenic activity of the novel compound. We hypothesized that the combination of these two epitopes would elicit a synergistic effect by targeting different angiogenesis pathways and result in improved potency, compared to that of a single epitope. This novel approach has resulted in the development of a potent, non-toxic, stable and cyclic analogue with nanomolar potency inhibition in in vitro endothelial cell migration and in vivo chorioallantoic membrane angiogenesis assays. This is the first report to use the MCoTI-II framework to develop a 2-in-1 anti-angiogenic peptide, which has the potential to be used as a form of combination therapy for targeting a wide range of cancers. PMID:27734947

  10. Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy.

    Science.gov (United States)

    Chan, Lai Yue; Craik, David J; Daly, Norelle L

    2016-10-13

    Peptide analogues derived from bioactive hormones such as somatostatin or certain growth factors have great potential as angiogenesis inhibitors for cancer applications. In an attempt to combat emerging drug resistance many FDA-approved anti-angiogenesis therapies are co-administered with cytotoxic drugs as a combination therapy to target multiple signaling pathways of cancers. However, cancer therapies often encounter limiting factors such as high toxicities and side effects. Here, we combined two anti-angiogenic epitopes that act on different pathways of angiogenesis into a single non-toxic cyclic peptide framework, namely MCoTI-II (Momordica cochinchinensis trypsin inhibitor-II), and subsequently assessed the anti-angiogenic activity of the novel compound. We hypothesized that the combination of these two epitopes would elicit a synergistic effect by targeting different angiogenesis pathways and result in improved potency, compared to that of a single epitope. This novel approach has resulted in the development of a potent, non-toxic, stable and cyclic analogue with nanomolar potency inhibition in in vitro endothelial cell migration and in vivo chorioallantoic membrane angiogenesis assays. This is the first report to use the MCoTI-II framework to develop a 2-in-1 anti-angiogenic peptide, which has the potential to be used as a form of combination therapy for targeting a wide range of cancers.

  11. Interactions of 160 GeV/Nucleon $^{207}$Pb Nuclei in Emulsion Chambers with Copper and Lead Targets

    CERN Multimedia

    2002-01-01

    % EMU13 \\\\ \\\\ Nuclear emulsions will be used as targets and trackers to investigate the interactions of $^{207}$Pb nuclei in emulsion, copper and lead targets; specifically (i) the pseudorapidity distributions of charged particles including analysis of particle fluctuations in pseudorapidity and azimuthal angle distributions, (ii) the transverse momentum distribution of $\\alpha$ fragments from the projectile nucleus. \\\\ \\\\Several emulsion chambers with different geometry and targets will be exposed to the $^{207}$Pb beam. Each chamber will be irradiated with the beam of low density $^{207}$Pb ions (several hundred per cm$^2$). Interactions with small impact parameter, characterized by high multiplicity and disruption of the projectile nucleus will be found with high efficiency. Measurements in the emulsion will include the number and emission angles of charged particles produced and the emission angles of $\\alpha$ fragments from the projectile nucleus.

  12. Peripheral Attentional Targets under Covert Attention Lead to Paradoxically Enhanced Alpha Desynchronization in Neurofibromatosis Type 1.

    Science.gov (United States)

    Silva, Gilberto; Ribeiro, Maria J; Costa, Gabriel N; Violante, Inês; Ramos, Fabiana; Saraiva, Jorge; Castelo-Branco, Miguel

    2016-01-01

    The limited capacity of the human brain to process the full extent of visual information reaching the visual cortex requires the recruitment of mechanisms of information selection through attention. Neurofibromatosis type-1 (NF1) is a neurodevelopmental disease often exhibiting attentional deficits and learning disabilities, and is considered to model similar impairments common in other neurodevelopmental disorders such as autism. In a previous study, we found that patients with NF1 are more prone to miss targets under overt attention conditions. This finding was interpreted as a result of increased occipito-parietal alpha oscillations. In the present study, we used electroencephalography (EEG) to study alpha power modulations and the performance of patients with NF1 in a covert attention task. Covert attention was required in order to perceive changes (target offset) of a peripherally presented stimulus. Interestingly, alpha oscillations were found to undergo greater desynchronization under this task in the NF1 group compared with control subjects. A similar pattern of desynchronization was found for beta frequencies while no changes in gamma oscillations could be identified. These results are consistent with the notion that different attentional states and task demands generate different patterns of abnormal modulation of alpha oscillatory processes in NF1. Under covert attention conditions and while target offset was reported with relatively high accuracy (over 90% correct responses), excessive desynchronization was found. These findings suggest an abnormal modulation of oscillatory activity and attentional processes in NF1. Given the known role of alpha in modulating attention, we suggest that alpha patterns can show both abnormal increases and decreases that are task and performance dependent, in a way that enhanced alpha desynchronization may reflect a compensatory mechanism to keep performance at normal levels. These results suggest that dysregulation of

  13. Peripheral Attentional Targets under Covert Attention Lead to Paradoxically Enhanced Alpha Desynchronization in Neurofibromatosis Type 1.

    Directory of Open Access Journals (Sweden)

    Gilberto Silva

    Full Text Available The limited capacity of the human brain to process the full extent of visual information reaching the visual cortex requires the recruitment of mechanisms of information selection through attention. Neurofibromatosis type-1 (NF1 is a neurodevelopmental disease often exhibiting attentional deficits and learning disabilities, and is considered to model similar impairments common in other neurodevelopmental disorders such as autism. In a previous study, we found that patients with NF1 are more prone to miss targets under overt attention conditions. This finding was interpreted as a result of increased occipito-parietal alpha oscillations. In the present study, we used electroencephalography (EEG to study alpha power modulations and the performance of patients with NF1 in a covert attention task. Covert attention was required in order to perceive changes (target offset of a peripherally presented stimulus. Interestingly, alpha oscillations were found to undergo greater desynchronization under this task in the NF1 group compared with control subjects. A similar pattern of desynchronization was found for beta frequencies while no changes in gamma oscillations could be identified. These results are consistent with the notion that different attentional states and task demands generate different patterns of abnormal modulation of alpha oscillatory processes in NF1. Under covert attention conditions and while target offset was reported with relatively high accuracy (over 90% correct responses, excessive desynchronization was found. These findings suggest an abnormal modulation of oscillatory activity and attentional processes in NF1. Given the known role of alpha in modulating attention, we suggest that alpha patterns can show both abnormal increases and decreases that are task and performance dependent, in a way that enhanced alpha desynchronization may reflect a compensatory mechanism to keep performance at normal levels. These results suggest that

  14. Cylindrical geometry hall thruster

    Science.gov (United States)

    Raitses, Yevgeny; Fisch, Nathaniel J.

    2002-01-01

    An apparatus and method for thrusting plasma, utilizing a Hall thruster with a cylindrical geometry, wherein ions are accelerated in substantially the axial direction. The apparatus is suitable for operation at low power. It employs small size thruster components, including a ceramic channel, with the center pole piece of the conventional annular design thruster eliminated or greatly reduced. Efficient operation is accomplished through magnetic fields with a substantial radial component. The propellant gas is ionized at an optimal location in the thruster. A further improvement is accomplished by segmented electrodes, which produce localized voltage drops within the thruster at optimally prescribed locations. The apparatus differs from a conventional Hall thruster, which has an annular geometry, not well suited to scaling to small size, because the small size for an annular design has a great deal of surface area relative to the volume.

  15. Targeting insulin-like growth factor 1 leads to amelioration of inflammatory demyelinating disease.

    Directory of Open Access Journals (Sweden)

    Matthew F Cusick

    Full Text Available In patients with multiple sclerosis (MS and in mice with experimental autoimmune encephalomyelitis (EAE, proliferating autoreactive T cells play an important role in the pathogenesis of the disease. Due to the importance of these myelin-specific T cells, these cells have been therapeutic targets in a variety of treatments. Previously we found that Lenaldekar (LDK, a novel small molecule, could inhibit exacerbations in a preclinical model of MS when given at the start of an EAE exacerbation. In those studies, we found that LDK could inhibit human T cell recall responses and murine myelin responses in vitro. In these new studies, we found that LDK could inhibit myelin specific T cell responses through the insulin-like growth factor-1 receptor (IGF-1R pathway. Alteration of this pathway led to marked reduction in T cell proliferation and expansion. Blocking this pathway could account for the observed decreases in clinical signs and inflammatory demyelinating disease, which was accompanied by axonal preservation. Our data indicate that IGF-1R could be a potential target for new therapies for the treatment of autoimmune diseases where autoreactive T cell expansion is a requisite for disease.

  16. Measurement of Gas and Volatile Elements Production Cross Section in a Molten Lead-Bismuth Target

    CERN Multimedia

    2002-01-01

    MEGAPIE is a project for a 1 MW liquid PbBi spallation source, to be built at the SINQ facility at the Paul Scherrer Institut, which will be an important step in the roadmap towards the demonstration of the ADS concept and high power molten metal targets in general. In the design and construction of such a challenging project it is extremely important to evaluate the amount and type of gas and volatile elements which will be produced, for a reliable and safe operation of the experiment. Both stable (H, $^{4}$He and other noble gases) and radioactive isotopes are of interest. Currently, different design options are under consideration to deal with the gas produced during operation. \\\\ For a correct estimation of the production cross sections, a measurement with a liquid PbBi target and a proton beam of energy close to the one of MEGAPIE (575 MeV) is necessary. We would like to use the ISOLDE facility, which offers the unique opportunity via its mass spectrometric analysis of the elements present in the gas pha...

  17. Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms

    Science.gov (United States)

    Bhagwat, Neha; Koppikar, Priya; Keller, Matthew; Marubayashi, Sachie; Shank, Kaitlyn; Rampal, Raajit; Qi, Jun; Kleppe, Maria; Patel, Hardik J.; Shah, Smit K.; Taldone, Tony; Bradner, James E.; Chiosis, Gabriela

    2014-01-01

    The discovery of JAK2/MPL mutations in patients with myeloproliferative neoplasms (MPN) led to clinical development of Janus kinase (JAK) inhibitors for treatment of MPN. These inhibitors improve constitutional symptoms and splenomegaly but do not significantly reduce mutant allele burden in patients. We recently showed that chronic exposure to JAK inhibitors results in inhibitor persistence via JAK2 transactivation and persistent JAK–signal transducer and activator of transcription signaling. We performed genetic and pharmacologic studies to determine whether improved JAK2 inhibition would show increased efficacy in MPN models and primary samples. Jak2 deletion in vivo led to profound reduction in disease burden not seen with JAK inhibitors, and deletion of Jak2 following chronic ruxolitinib therapy markedly reduced mutant allele burden. This demonstrates that JAK2 remains an essential target in MPN cells that survive in the setting of chronic JAK inhibition. Combination therapy with the heat shock protein 90 (HSP90) inhibitor PU-H71 and ruxolitinib reduced total and phospho-JAK2 and achieved more potent inhibition of downstream signaling than ruxolitinib monotherapy. Combination treatment improved blood counts, spleen weights, and reduced bone marrow fibrosis compared with ruxolitinib alone. These data suggest alternate approaches that increase JAK2 targeting, including combination JAK/HSP90 inhibitor therapy, are warranted in the clinical setting. PMID:24470592

  18. Left ventricular pacing lead positioning in the target vein of the coronary sinus: description of a challenging case.

    Science.gov (United States)

    Frattini, Folco; Rordorf, Roberto; Angoli, Luigi; Pentimalli, Francesco; Vicentini, Alessandro; Petracci, Barbara; Magrini, Giulia; Landolina, Maurizio

    2008-04-01

    The optimal left ventricular pacing location for cardiac resynchronization therapy should be individualized according to the site of maximal mechanical delay. However, the presence of vein stenosis or kinking in coronary sinus (CS) anatomy could hamper lead implantation in the target vessel. We describe the case of a patient with dilated cardiomyopathy and a dual-chamber pacemaker referred for upgrading to a biventricular device owing to New York Heart Association III heart failure symptoms. Tissue Doppler analysis before implantation showed that the area of maximum activation delay was located in the posterolateral region of the left ventricle. Insertion of the lead into a posterolateral vein of the CS by means of the standard over-the-wire approach was unsuccessful due to the presence of a stenosis at the ostium of the vein. Lead placement in an anterior vein of the CS was unsatisfactory owing to a poor local delay from QRS onset. After balloon vein angioplasty, the pacing lead passed through the stenotic tract at the ostium of the target vein and was successfully positioned in the posterolateral region. Three months after pacemaker implantation, echocardiography showed an important reduction in the indexes of both inter- and intraventricular asynchrony and a significant left ventricular reverse remodeling.

  19. Fragile X and autism : intertwined at the molecular level leading to targeted treatments

    OpenAIRE

    Hoem, Gry

    2012-01-01

    Fragile X syndrome (FXS) is caused by an expanded CGG repeat (>200 repeats) in the 5’ un-translated portion of the fragile mental retardation 1 gene (FMR1) leading to deficiency or absence of the FMR1 protein (FMRP). FMRP is an RNA carrier protein that controls the translation of a number of other genes that regulate synaptic development and plasticity. Autism occurs in approximately 30% of FXS cases, and Pervasive Developmental Disorder, Not Otherwise Specified (PDD-NOS) occurs in an additio...

  20. Spallation yield of neutrons produced in thick lead target bombarded with 250 MeV protons

    Energy Technology Data Exchange (ETDEWEB)

    Chen, L. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Ma, F., E-mail: mf@impcas.ac.cn [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Zhanga, X.Y.; Ju, Y.Q.; Zhang, H.B.; Ge, H.L.; Wang, J.G. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Zhou, B. [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Li, Y.Y.; Xu, X.W. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Luo, P.; Yang, L.; Zhang, Y.B.; Li, J.Y.; Xu, J.K. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Liang, T.J. [Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China); Wang, S.L. [University of Chinese Academy of Sciences, Beijing 100049 (China); Yang, Y.W.; Gu, L. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China)

    2015-01-01

    The neutron yield from thick target of Pb irradiated with 250 MeV protons has been studied experimentally. The neutron production was measured with the water-bath gold method. The thermal neutron distributions in the water were determined according to the measured activities of Au foils. Corresponding results calculated with the Monte Carlo code MCNPX were compared with the experimental data. It was found out that the Au foils with cadmium cover significantly changed the spacial distribution of the thermal neutron field. The corrected neutron yield was deduced to be 2.23±0.19 n/proton by considering the influence of the Cd cover on the thermal neutron flux.

  1. Spallation yield of neutrons produced in thick lead target bombarded with 250 MeV protons

    Science.gov (United States)

    Chen, L.; Ma, F.; Zhanga, X. Y.; Ju, Y. Q.; Zhang, H. B.; Ge, H. L.; Wang, J. G.; Zhou, B.; Li, Y. Y.; Xu, X. W.; Luo, P.; Yang, L.; Zhang, Y. B.; Li, J. Y.; Xu, J. K.; Liang, T. J.; Wang, S. L.; Yang, Y. W.; Gu, L.

    2015-01-01

    The neutron yield from thick target of Pb irradiated with 250 MeV protons has been studied experimentally. The neutron production was measured with the water-bath gold method. The thermal neutron distributions in the water were determined according to the measured activities of Au foils. Corresponding results calculated with the Monte Carlo code MCNPX were compared with the experimental data. It was found out that the Au foils with cadmium cover significantly changed the spacial distribution of the thermal neutron field. The corrected neutron yield was deduced to be 2.23 ± 0.19 n/proton by considering the influence of the Cd cover on the thermal neutron flux.

  2. Targeting acetylcholinesterase: identification of chemical leads by high throughput screening, structure determination and molecular modeling.

    Directory of Open Access Journals (Sweden)

    Lotta Berg

    Full Text Available Acetylcholinesterase (AChE is an essential enzyme that terminates cholinergic transmission by rapid hydrolysis of the neurotransmitter acetylcholine. Compounds inhibiting this enzyme can be used (inter alia to treat cholinergic deficiencies (e.g. in Alzheimer's disease, but may also act as dangerous toxins (e.g. nerve agents such as sarin. Treatment of nerve agent poisoning involves use of antidotes, small molecules capable of reactivating AChE. We have screened a collection of organic molecules to assess their ability to inhibit the enzymatic activity of AChE, aiming to find lead compounds for further optimization leading to drugs with increased efficacy and/or decreased side effects. 124 inhibitors were discovered, with considerable chemical diversity regarding size, polarity, flexibility and charge distribution. An extensive structure determination campaign resulted in a set of crystal structures of protein-ligand complexes. Overall, the ligands have substantial interactions with the peripheral anionic site of AChE, and the majority form additional interactions with the catalytic site (CAS. Reproduction of the bioactive conformation of six of the ligands using molecular docking simulations required modification of the default parameter settings of the docking software. The results show that docking-assisted structure-based design of AChE inhibitors is challenging and requires crystallographic support to obtain reliable results, at least with currently available software. The complex formed between C5685 and Mus musculus AChE (C5685•mAChE is a representative structure for the general binding mode of the determined structures. The CAS binding part of C5685 could not be structurally determined due to a disordered electron density map and the developed docking protocol was used to predict the binding modes of this part of the molecule. We believe that chemical modifications of our discovered inhibitors, biochemical and biophysical

  3. Neonicotinoids target distinct nicotinic acetylcholine receptors and neurons, leading to differential risks to bumblebees

    Science.gov (United States)

    Moffat, Christopher; Buckland, Stephen T.; Samson, Andrew J.; McArthur, Robin; Chamosa Pino, Victor; Bollan, Karen A.; Huang, Jeffrey T.-J.; Connolly, Christopher N.

    2016-04-01

    There is growing concern over the risk to bee populations from neonicotinoid insecticides and the long-term consequences of reduced numbers of insect pollinators to essential ecosystem services and food security. Our knowledge of the risk of neonicotinoids to bees is based on studies of imidacloprid and thiamethoxam and these findings are extrapolated to clothianidin based on its higher potency at nicotinic acetylcholine receptors. This study addresses the specificity and consequences of all three neonicotinoids to determine their relative risk to bumblebees at field-relevant levels (2.5 ppb). We find compound-specific effects at all levels (individual cells, bees and whole colonies in semi-field conditions). Imidacloprid and clothianidin display distinct, overlapping, abilities to stimulate Kenyon cells, indicating the potential to differentially influence bumblebee behavior. Bee immobility was induced only by imidacloprid, and an increased vulnerability to clothianidin toxicity only occurred following chronic exposure to clothianidin or thiamethoxam. At the whole colony level, only thiamethoxam altered the sex ratio (more males present) and only clothianidin increased queen production. Finally, both imidacloprid and thiamethoxam caused deficits in colony strength, while no detrimental effects of clothianidin were observed. Given these findings, neonicotinoid risk needs to be considered independently for each compound and target species.

  4. Determination of Coil Inductances Cylindrical Iron Nucleus

    Directory of Open Access Journals (Sweden)

    Azeddine Mazouz

    2014-03-01

    Full Text Available The paper describes the investigation and development of a structure and performance characteristics of a coil iron nucleus cylindrical (C.I.N.C. The coil iron nucleus cylindrical is a nonlinear electro radio in which the moving of the nucleus in a sense or in other causes change in inductance and can reach extreme values at the superposition of nucleus and coil centers. The variation of the inductance and the degree of freedom of movement of the nucleus can lead to a device with electromechanical conversion The aim of this paper is the determination and visualization of self inductance and mutual of the (C.I.N.C based on geometric dimensions and the displacement of the nucleus.  

  5. Optimized hydrophobic interactions and hydrogen bonding at the target-ligand interface leads the pathways of drug-designing.

    Directory of Open Access Journals (Sweden)

    Rohan Patil

    Full Text Available BACKGROUND: Weak intermolecular interactions such as hydrogen bonding and hydrophobic interactions are key players in stabilizing energetically-favored ligands, in an open conformational environment of protein structures. However, it is still poorly understood how the binding parameters associated with these interactions facilitate a drug-lead to recognize a specific target and improve drugs efficacy. To understand this, comprehensive analysis of hydrophobic interactions, hydrogen bonding and binding affinity have been analyzed at the interface of c-Src and c-Abl kinases and 4-amino substituted 1H-pyrazolo [3, 4-d] pyrimidine compounds. METHODOLOGY: In-silico docking studies were performed, using Discovery Studio software modules LigandFit, CDOCKER and ZDOCK, to investigate the role of ligand binding affinity at the hydrophobic pocket of c-Src and c-Abl kinase. Hydrophobic and hydrogen bonding interactions of docked molecules were compared using LigPlot program. Furthermore, 3D-QSAR and MFA calculations were scrutinized to quantify the role of weak interactions in binding affinity and drug efficacy. CONCLUSIONS: The in-silico method has enabled us to reveal that a multi-targeted small molecule binds with low affinity to its respective targets. But its binding affinity can be altered by integrating the conformationally favored functional groups at the active site of the ligand-target interface. Docking studies of 4-amino-substituted molecules at the bioactive cascade of the c-Src and c-Abl have concluded that 3D structural folding at the protein-ligand groove is also a hallmark for molecular recognition of multi-targeted compounds and for predicting their biological activity. The results presented here demonstrate that hydrogen bonding and optimized hydrophobic interactions both stabilize the ligands at the target site, and help alter binding affinity and drug efficacy.

  6. Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.

    Science.gov (United States)

    Klint, Julie K; Senff, Sebastian; Rupasinghe, Darshani B; Er, Sing Yan; Herzig, Volker; Nicholson, Graham M; King, Glenn F

    2012-09-15

    Voltage-gated sodium (Na(V)) channels play a central role in the propagation of action potentials in excitable cells in both humans and insects. Many venomous animals have therefore evolved toxins that modulate the activity of Na(V) channels in order to subdue their prey and deter predators. Spider venoms in particular are rich in Na(V) channel modulators, with one-third of all known ion channel toxins from spider venoms acting on Na(V) channels. Here we review the landscape of spider-venom peptides that have so far been described to target vertebrate or invertebrate Na(V) channels. These peptides fall into 12 distinct families based on their primary structure and cysteine scaffold. Some of these peptides have become useful pharmacological tools, while others have potential as therapeutic leads because they target specific Na(V) channel subtypes that are considered to be important analgesic targets. Spider venoms are conservatively predicted to contain more than 10 million bioactive peptides and so far only 0.01% of this diversity been characterised. Thus, it is likely that future research will reveal additional structural classes of spider-venom peptides that target Na(V) channels.

  7. Identification and Functional Analysis of MicroRNAs and Their Targets in Platanus acerifolia under Lead (Pb Stress

    Directory of Open Access Journals (Sweden)

    Yuanlong Wang

    2015-03-01

    Full Text Available MicroRNAs (miRNAs play important regulatory roles in development and stress responses in plants. Lead (Pb is a non-essential element that is highly toxic to living organisms. Platanus acerifolia is grown as a street tree in cities throughout temperate regions for its importance in improving the urban ecological environment. MiRNAs that respond to abiotic stresses have been identified in plants; however, until now, the influence of Pb stress on P. acerifolia miRNAs has not been reported. To identify miRNAs and predict their target genes under Pb stress, two small RNA and two degradome libraries were constructed from Pb-treated and Pb-free leaves of P. acerifolia seedlings. After sequencing, 55 known miRNAs and 129 novel miRNAs were obtained, and 104 target genes for the miRNAs were identified by degradome sequencing. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed to predict the functions of the targets. The expressions of eight differentially expressed miRNAs were validated by quantitative real-time polymerase chain reaction (qRT-PCR. This is the first report about P. acerifolia miRNAs and their target genes under Pb stress. This study has provided data for further research into molecular mechanisms involved in resistance of P. acerifolia to Pb stress.

  8. The Effect of Beam Intensity on Temperature Distribution in ADS Windowless Lead-Bismuth Eutectic Spallation Target

    Directory of Open Access Journals (Sweden)

    Jie Liu

    2014-01-01

    Full Text Available The spallation target is the component coupling the accelerator and the reactor and is regarded as the “heart” of the accelerator driven system (ADS. Heavy liquid metal lead-bismuth eutectic (LBE is served as core coolant and spallation material to carry away heat deposition of spallation reaction and produce high flux neutron. So it is very important to study the heat transfer process in the target. In this paper, the steady-state flow pattern has been numerically obtained and taken as the input for the nuclear physics calculation, and then the distribution of the extreme large power density of the heat load is imported back to the computational fluid dynamics as the source term in the energy equation. Through the coupling, the transient and steady-state temperature distribution in the windowless spallation target is obtained and analyzed based on the flow process and heat transfer. Comparison of the temperature distribution with the different beam intensity shows that its shape is the same as broken wing of the butterfly. Nevertheless, the maximum temperature as well as the temperature gradient is different. The results play an important role and can be applied to the further design and optimization of the ADS windowless spallation target.

  9. Identification and Functional Analysis of MicroRNAs and Their Targets in Platanus acerifolia under Lead (Pb) Stress

    Science.gov (United States)

    Wang, Yuanlong; Zhao, Zhenli; Deng, Minjie; Liu, Rongning; Niu, Suyan; Fan, Guoqiang

    2015-01-01

    MicroRNAs (miRNAs) play important regulatory roles in development and stress responses in plants. Lead (Pb) is a non-essential element that is highly toxic to living organisms. Platanus acerifolia is grown as a street tree in cities throughout temperate regions for its importance in improving the urban ecological environment. MiRNAs that respond to abiotic stresses have been identified in plants; however, until now, the influence of Pb stress on P. acerifolia miRNAs has not been reported. To identify miRNAs and predict their target genes under Pb stress, two small RNA and two degradome libraries were constructed from Pb-treated and Pb-free leaves of P. acerifolia seedlings. After sequencing, 55 known miRNAs and 129 novel miRNAs were obtained, and 104 target genes for the miRNAs were identified by degradome sequencing. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed to predict the functions of the targets. The expressions of eight differentially expressed miRNAs were validated by quantitative real-time polymerase chain reaction (qRT-PCR). This is the first report about P. acerifolia miRNAs and their target genes under Pb stress. This study has provided data for further research into molecular mechanisms involved in resistance of P. acerifolia to Pb stress. PMID:25830479

  10. Cylindrically symmetric dust spacetime

    CERN Document Server

    Senovilla, J M M; Senovilla, Jose M. M.; Vera, Raul

    2000-01-01

    We present an explicit exact solution of Einstein's equations for an inhomogeneous dust universe with cylindrical symmetry. The spacetime is extremely simple but nonetheless it has new surprising features. The universe is ``closed'' in the sense that the dust expands from a big-bang singularity but recollapses to a big-crunch singularity. In fact, both singularities are connected so that the whole spacetime is ``enclosed'' within a single singularity of general character. The big-bang is not simultaneous for the dust, and in fact the age of the universe as measured by the dust particles depends on the spatial position, an effect due to the inhomogeneity, and their total lifetime has no non-zero lower limit. Part of the big-crunch singularity is naked. The metric depends on a parameter and contains flat spacetime as a non-singular particular case. For appropriate values of the parameter the spacetime is a small perturbation of Minkowski spacetime. This seems to indicate that flat spacetime may be unstable agai...

  11. Cylindrically symmetric dust spacetime

    Science.gov (United States)

    Senovilla, José M. M.

    2000-07-01

    We present an explicit exact solution of Einstein's equations for an inhomogeneous dust universe with cylindrical symmetry. The spacetime is extremely simple but nonetheless it has surprising new features. The universe is `closed' in the sense that the dust expands from a big-bang singularity but recollapses to a big-crunch singularity. In fact, both singularities are connected so that the whole spacetime is `enclosed' within a single singularity of general character. The big-bang is not simultaneous for the dust, and in fact the age of the universe as measured by the dust particles depends on the spatial position, an effect due to the inhomogeneity, and their total lifetime has no non-zero lower limit. Part of the big-crunch singularity is naked. The metric depends on a parameter and contains flat spacetime as a non-singular particular case. For appropriate values of the parameter the spacetime is a small perturbation of Minkowski spacetime. This seems to indicate that flat spacetime may be unstable against some global non-vacuum perturbations.

  12. Cylindric-like algebras and algebraic logic

    CERN Document Server

    Ferenczi, Miklós; Németi, István

    2013-01-01

    Algebraic logic is a subject in the interface between logic, algebra and geometry, it has strong connections with category theory and combinatorics. Tarski’s quest for finding structure in logic leads to cylindric-like algebras as studied in this book, they are among the main players in Tarskian algebraic logic. Cylindric algebra theory can be viewed in many ways:  as an algebraic form of definability theory, as a study of higher-dimensional relations, as an enrichment of Boolean Algebra theory, or, as logic in geometric form (“cylindric” in the name refers to geometric aspects). Cylindric-like algebras have a wide range of applications, in, e.g., natural language theory, data-base theory, stochastics, and even in relativity theory. The present volume, consisting of 18 survey papers, intends to give an overview of the main achievements and new research directions in the past 30 years, since the publication of the Henkin-Monk-Tarski monographs. It is dedicated to the memory of Leon Henkin.

  13. Experimental new automatic tools for robotic stereotactic neurosurgery: towards "no hands" procedure of leads implantation into a brain target.

    Science.gov (United States)

    Mazzone, P; Arena, P; Cantelli, L; Spampinato, G; Sposato, S; Cozzolino, S; Demarinis, P; Muscato, G

    2016-07-01

    The use of robotics in neurosurgery and, particularly, in stereotactic neurosurgery, is becoming more and more adopted because of the great advantages that it offers. Robotic manipulators easily allow to achieve great precision, reliability, and rapidity in the positioning of surgical instruments or devices in the brain. The aim of this work was to experimentally verify a fully automatic "no hands" surgical procedure. The integration of neuroimaging to data for planning the surgery, followed by application of new specific surgical tools, permitted the realization of a fully automated robotic implantation of leads in brain targets. An anthropomorphic commercial manipulator was utilized. In a preliminary phase, a software to plan surgery was developed, and the surgical tools were tested first during a simulation and then on a skull mock-up. In such a way, several tools were developed and tested, and the basis for an innovative surgical procedure arose. The final experimentation was carried out on anesthetized "large white" pigs. The determination of stereotactic parameters for the correct planning to reach the intended target was performed with the same technique currently employed in human stereotactic neurosurgery, and the robotic system revealed to be reliable and precise in reaching the target. The results of this work strengthen the possibility that a neurosurgeon may be substituted by a machine, and may represent the beginning of a new approach in the current clinical practice. Moreover, this possibility may have a great impact not only on stereotactic functional procedures but also on the entire domain of neurosurgery.

  14. Shock initiated instabilities in underwater cylindrical structures

    Science.gov (United States)

    Gupta, Sachin; Matos, Helio; LeBlanc, James M.; Shukla, Arun

    2016-10-01

    An experimental investigation to understand the mechanisms of dynamic buckling instability in cylindrical structures due to underwater explosive loadings is conducted. In particular, the effects of initial hydrostatic pressure coupled with a dynamic pressure pulse on the stability of metallic cylindrical shells are evaluated. The experiments are conducted at varying initial hydrostatic pressures, below the critical buckling pressure, to estimate the threshold after which dynamic buckling will initiate. The transient underwater full-field deformations of the structures during shock wave loading are captured using high-speed stereo photography coupled with modified 3-D Digital Image Correlation (DIC) technique. Experimental results show that increasing initial hydrostatic pressure decreases the natural vibration frequency of the structure indicating loss in structural stiffness. DIC measurements reveal that the initial structural excitations primarily consist of axisymmetric vibrations due to symmetrical shock wave loading in the experiments. Following their decay after a few longitudinal reverberations, the primary mode of vibration evolves which continues throughout later in time. At the initial hydrostatic pressures below the threshold value, these vibrations are stable in nature. The analytical solutions for the vibration frequency and the transient response of cylindrical shell are discussed in the article by accounting for both (1) the added mass effect of the surrounding water and (2) the effect of initial stress on the shell imposed by the hydrostatic pressure. The analytical solutions match reasonably well with the experimental vibration frequencies. Later, the transient response of a cylindrical shell subjected to a general underwater pressure wave loading is derived which leads to the analytical prediction of dynamic stability.

  15. Using environmental public health tracking to identify community targets for public health actions in childhood lead poisoning in Wisconsin.

    Science.gov (United States)

    Berney, Dawn; Camponeschi, Jenny; Coons, Marjorie; Creswell, Paul D; Schirmer, Joe; Walsh, Reghan

    2015-01-01

    In an effort to improve the ability of local public health departments to target resources to the highest need regions, the Wisconsin Environmental Public Health Tracking (WI EPHT) Program worked to enhance its public portal to benefit the Wisconsin Childhood Lead Poisoning Prevention Program (WCLPPP) and other programs. The WI EPHT Program conducted this enhancement in collaboration with WCLPPP. The WI EPHT enhanced public portal is the next phase of Wisconsin's ongoing efforts in environmental public health tracking. As part of this process, this new mapping application includes mapping capacity that provides information on childhood lead testing and results at county and census tract levels in Wisconsin. The WI EPHT Program will update its public portal to have the capability to map data at a subcounty level (ie, census tract or zip code) for some data topics when such data are available. This tool is available to local public health departments and other public health organizations throughout Wisconsin as a resource to identify communities most affected by the Centers for Disease Control and Prevention's new guidelines with regard to childhood lead poisoning. The collaboration between WI EPHT and WCLPPP on updating and enhancing the portal exemplifies the power of environmental health data to inform a more accurate understanding of public health problems.

  16. Cellular Cell Bifurcation of Cylindrical Detonations

    Institute of Scientific and Technical Information of China (English)

    HAN Gui-Lai; JIANG Zong-Lin; WANG Chun; ZHANG Fan

    2008-01-01

    Cellular cell pattern evolution of cylindrically-diverging detonations is numerically simulated successfully by solving two-dimensional Euler equations implemented with an improved two-step chemical kinetic model. From the simulation, three cell bifurcation modes are observed during the evolution and referred to as concave front focusing, kinked and wrinkled wave front instability, and self-merging of cellular cells. Numerical research demonstrates that the wave front expansion resulted from detonation front diverging plays a major role in the cellular cell bifurcation, which can disturb the nonlinearly self-sustained mechanism of detonations and finally lead to cell bifurcations.

  17. Post-irradiation analysis of an ISOLDE lead-bismuth target: Stable and long-lived noble gas nuclides

    Science.gov (United States)

    Leya, I.; Grimberg, A.; David, J.-C.; Schumann, D.; Neuhausen, J.; Zanini, L.; Noah, E.

    2016-07-01

    We measured the isotopic concentrations of long-lived and stable He, Ne, Ar, Kr, and Xe isotopes in a sample from a lead-bismuth eutectic target irradiated with 1.0 and 1.4 GeV protons. Our data indicate for most noble gases nearly complete release with retention fractions in the range of percent or less. Higher retention fractions result from the decay of long-lived radioactive progenitors from groups 1, 2, or 7 of the periodic table. From the data we can calculate a retention fraction for 3H of 2-3%. For alkaline metals we find retention fractions of about 10%, 30%, and 50% for Na, Rb, and Cs, respectively. For the alkaline earth metal Ba we found complete retention. Finally, the measured Kr and Xe concentrations indicate that there was some release of the halogens Br and I during and/or after the irradiation.

  18. Spatial distribution of neutrons in paraffin moderator surrounding a lead target irradiated with protons at intermediate energies

    CERN Document Server

    Adam, J; Bradnova, V

    2002-01-01

    The distribution of neutrons emitted during the irradiation with 0.65, 1.0 and 1.5 GeV protons from a lead target (O / = 8 cm, l = 20 cm) and moderated by a surrounding paraffin moderator of 6 cm thick was studied with a radiochemical sensor along the beam axis on top of the moderator. Small sup 1 sup 3 sup 9 La-sensors of approximately 1 g were used to measure essentially the thermal neutron fluence at different depths near the surface: i.e., on top of the moderator, in 10 mm deep holes and in 20 mm deep holes. The reaction sup 1 sup 3 sup 9 La(n, gamma) sup 1 sup 4 sup 0 La (tau sub 1 sub / sub 2 = 40.27 h) was studied using standard procedures of gamma spectroscopy and data analysis. The neutron induced activity of sup 1 sup 4 sup 0 La increases strongly with the depth of the hole inside the moderator, its activity distribution along the beam direction on top of the moderator has its maximum about 10 cm downstream the entrance of the protons into the lead and the induced activity increases about linearity ...

  19. Telescoping cylindrical piezoelectric fiber composite actuator assemblies

    Science.gov (United States)

    Allison, Sidney G. (Inventor); Shams, Qamar A. (Inventor); Fox, Robert L. (Inventor); Fox, legal representative, Christopher L. (Inventor); Fox Chattin, legal representative, Melanie L. (Inventor)

    2010-01-01

    A telescoping actuator assembly includes a plurality of cylindrical actuators in a concentric arrangement. Each cylindrical actuator is at least one piezoelectric fiber composite actuator having a plurality of piezoelectric fibers extending parallel to one another and to the concentric arrangement's longitudinal axis. Each cylindrical actuator is coupled to concentrically-adjacent ones of the cylindrical actuators such that the plurality of cylindrical actuators can experience telescopic movement. An electrical energy source coupled to the cylindrical actuators applies actuation energy thereto to generate the telescopic movement.

  20. Dismantling OPAL's cylindrical magnet core

    CERN Multimedia

    Laurent Guiraud

    2001-01-01

    Lifting a handling device for dismounting the pressure bells, which are inside the cylindrical magnet coil on the central section of OPAL, on the right part of the photo. OPAL was a detector on the LEP accelerator, which ran from 1989 to 2000.

  1. Optics Demonstrations Using Cylindrical Lenses

    Science.gov (United States)

    Ivanov, Dragia; Nikolov, Stefan

    2015-01-01

    In this paper we consider the main properties of cylindrical lenses and propose several demonstrational experiments that can be performed with them. Specifically we use simple glasses full of water to demonstrate some basic geometrical optics principles and phenomena. We also present some less standard experiments that can be performed with such…

  2. Motion parallax in immersive cylindrical display systems

    Science.gov (United States)

    Filliard, N.; Reymond, G.; Kemeny, A.; Berthoz, A.

    2012-03-01

    Motion parallax is a crucial visual cue produced by translations of the observer for the perception of depth and selfmotion. Therefore, tracking the observer viewpoint has become inevitable in immersive virtual (VR) reality systems (cylindrical screens, CAVE, head mounted displays) used e.g. in automotive industry (style reviews, architecture design, ergonomics studies) or in scientific studies of visual perception. The perception of a stable and rigid world requires that this visual cue be coherent with other extra-retinal (e.g. vestibular, kinesthetic) cues signaling ego-motion. Although world stability is never questioned in real world, rendering head coupled viewpoint in VR can lead to the perception of an illusory perception of unstable environments, unless a non-unity scale factor is applied on recorded head movements. Besides, cylindrical screens are usually used with static observers due to image distortions when rendering image for viewpoints different from a sweet spot. We developed a technique to compensate in real-time these non-linear visual distortions, in an industrial VR setup, based on a cylindrical screen projection system. Additionally, to evaluate the amount of discrepancies tolerated without perceptual distortions between visual and extraretinal cues, a "motion parallax gain" between the velocity of the observer's head and that of the virtual camera was introduced in this system. The influence of this artificial gain was measured on the gait stability of free-standing participants. Results indicate that, below unity, gains significantly alter postural control. Conversely, the influence of higher gains remains limited, suggesting a certain tolerance of observers to these conditions. Parallax gain amplification is therefore proposed as a possible solution to provide a wider exploration of space to users of immersive virtual reality systems.

  3. A cylindrical specimen holder for electron cryo-tomography

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, Colin M., E-mail: cpalmer@mrc-lmb.cam.ac.uk; Löwe, Jan, E-mail: jyl@mrc-lmb.cam.ac.uk

    2014-02-01

    The use of slab-like flat specimens for electron cryo-tomography restricts the range of viewing angles that can be used. This leads to the “missing wedge” problem, which causes artefacts and anisotropic resolution in reconstructed tomograms. Cylindrical specimens provide a way to eliminate the problem, since they allow imaging from a full range of viewing angles around the tilt axis. Such specimens have been used before for tomography of radiation-insensitive samples at room temperature, but never for frozen-hydrated specimens. Here, we demonstrate the use of thin-walled carbon tubes as specimen holders, allowing the preparation of cylindrical frozen-hydrated samples of ribosomes, liposomes and whole bacterial cells. Images acquired from these cylinders have equal quality at all viewing angles, and the accessible tilt range is restricted only by the physical limits of the microscope. Tomographic reconstructions of these specimens demonstrate that the effects of the missing wedge are substantially reduced, and could be completely eliminated if a full tilt range was used. The overall quality of these tomograms is still lower than that obtained by existing methods, but improvements are likely in future. - Highlights: • The missing wedge is a serious problem for electron cryo-tomography. • Cylindrical specimens allow the missing wedge to be eliminated. • Carbon nanopipettes can be used as cylindrical holders for tomography of frozen-hydrated specimens. • Cryo-tomography of cylindrical biological samples demonstrates a reduction of deleterious effects associated with the missing wedge.

  4. Multimode interaction in axially excited cylindrical shells

    Directory of Open Access Journals (Sweden)

    Silva F. M. A.

    2014-01-01

    Full Text Available Cylindrical shells exhibit a dense frequency spectrum, especially near the lowest frequency range. In addition, due to the circumferential symmetry, frequencies occur in pairs. So, in the vicinity of the lowest natural frequencies, several equal or nearly equal frequencies may occur, leading to a complex dynamic behavior. So, the aim of the present work is to investigate the dynamic behavior and stability of cylindrical shells under axial forcing with multiple equal or nearly equal natural frequencies. The shell is modelled using the Donnell nonlinear shallow shell theory and the discretized equations of motion are obtained by applying the Galerkin method. For this, a modal solution that takes into account the modal interaction among the relevant modes and the influence of their companion modes (modes with rotational symmetry, which satisfies the boundary and continuity conditions of the shell, is derived. Special attention is given to the 1:1:1:1 internal resonance (four interacting modes. Solving numerically the governing equations of motion and using several tools of nonlinear dynamics, a detailed parametric analysis is conducted to clarify the influence of the internal resonances on the bifurcations, stability boundaries, nonlinear vibration modes and basins of attraction of the structure.

  5. TARGET:?

    National Research Council Canada - National Science Library

    James M Acton

    2014-01-01

      By 2003. as military planners had become worried that the country's long-range conventional weapons, such as cruise missiles, might be too slow to reach hypothetical distant targets that needed to be struck urgently...

  6. Improved cylindrical mirror energy analyzer

    Science.gov (United States)

    Baranova, L. A.

    2017-03-01

    A study has been carried out of the electron-optical properties of improved design of the cylindrical mirror energy analyzer. Both external and internal electrodes of the analyzer are divided into three isolated parts, whereby the potentials on the individual parts can be regulated independently from each other. In symmetric operating mode at identical potentials on the side parts of the electrodes, a significant increase has been obtained in resolving power and light-gathering power of the analyzer compared to the standard design of the cylindrical mirror. In asymmetric operating mode, which is implemented in a linear potential distribution on the external electrode, the conditions have been found under which the linear dispersion of the analyzer increases several times.

  7. Cylindrical solutions in mimetic gravity

    Energy Technology Data Exchange (ETDEWEB)

    Momeni, Davood; Myrzakulov, Kairat; Myrzakulov, Ratbay [Eurasian National University, Eurasian International Center for Theoretical Physics and Department of General and Theoretical Physics, Astana (Kazakhstan); Raza, Muhammad [COMSATS Institute of Information Technology, Department of Mathematics, Sahiwal (Pakistan)

    2016-06-15

    This paper is devoted to investigate cylindrical solutions in mimetic gravity. The explicit forms of the metric of this theory, namely mimetic-Kasner (say) have been obtained. In this study we have noticed that the Kasner's family of exact solutions needs to be reconsidered under this type of modified gravity. A no-go theorem is proposed for the exact solutions in the presence of a cosmological constant. (orig.)

  8. Cylindrical Collapse and Gravitational Waves

    CERN Document Server

    Herrera, L

    2005-01-01

    We study the matching conditions for a collapsing anisotropic cylindrical perfect fluid, and we show that its radial pressure is non zero on the surface of the cylinder and proportional to the time dependent part of the field produced by the collapsing fluid. This result resembles the one that arises for the radiation - though non-gravitational - in the spherically symmetric collapsing dissipative fluid, in the diffusion approximation.

  9. Cylindrical Piezoelectric Fiber Composite Actuators

    Science.gov (United States)

    Allison, Sidney G.; Shams, Qamar A.; Fox, Robert L.

    2008-01-01

    The use of piezoelectric devices has become widespread since Pierre and Jacques Curie discovered the piezoelectric effect in 1880. Examples of current applications of piezoelectric devices include ultrasonic transducers, micro-positioning devices, buzzers, strain sensors, and clocks. The invention of such lightweight, relatively inexpensive piezoceramic-fiber-composite actuators as macro fiber composite (MFC) actuators has made it possible to obtain strains and displacements greater than those that could be generated by prior actuators based on monolithic piezoceramic sheet materials. MFC actuators are flat, flexible actuators designed for bonding to structures to apply or detect strains. Bonding multiple layers of MFC actuators together could increase force capability, but not strain or displacement capability. Cylindrical piezoelectric fiber composite (CPFC) actuators have been invented as alternatives to MFC actuators for applications in which greater forces and/or strains or displacements may be required. In essence, a CPFC actuator is an MFC or other piezoceramic fiber composite actuator fabricated in a cylindrical instead of its conventional flat shape. Cylindrical is used here in the general sense, encompassing shapes that can have circular, elliptical, rectangular or other cross-sectional shapes in the planes perpendicular to their longitudinal axes.

  10. The generation of purinome-targeted libraries as a means to diversify ATP-mimetic chemical classes for lead finding.

    Science.gov (United States)

    Felder, Eduard R; Badari, Alessandra; Disingrini, Teresa; Mantegani, Sergio; Orrenius, Christian; Avanzi, Nilla; Isacchi, Antonella; Salom, Barbara

    2012-02-01

    The generation of novel chemotypes in support of our oncology research projects expanded in recent years from a canonical design of kinase-targeted compound libraries to a broader interpretation of purinome-targeted libraries (PTL) addressing the specificity of cancer relevant targets such as kinases and ATPases. Successful screening of structurally diverse ATP-binding targets requires compound libraries covering multiple design elements, which may include phosphate surrogate moieties in ATPase inhibitors or far reaching lipophilic residues stabilizing inactive kinase conformations. Here, we exemplify the design and preparation of drug-like combinatorial libraries and report significantly enhanced screening performance on purinomic targets. We compared overall hit rates of PTL with a simultaneously tested unbiased collection of 200,000 compounds and found consistent superiority of the targeted libraries in all cases. We also analyzed the performance of the largest targeted libraries in comparison with each other and often found striking differences in how a specific target responds to various chemotypes and to whole collections.

  11. Combinatorial Screening Identifies Novel Promiscuous Matrix Metalloproteinase Activities that Lead to Inhibition of the Therapeutic Target IL-13

    NARCIS (Netherlands)

    Urbach, Carole; Gordon, Nathaniel C; Strickland, Ian; Lowne, David; Joberty-Candotti, Cathy; May, Richard; Herath, Athula; Hijnen, DirkJan; Thijs, Judith L; Bruijnzeel-Koomen, Carla A; Minter, Ralph R; Hollfelder, Florian; Jermutus, Lutz

    2015-01-01

    The practical realization of disease modulation by catalytic degradation of a therapeutic target protein suffers from the difficulty to identify candidate proteases, or to engineer their specificity. We identified 23 measurable, specific, and new protease activities using combinatorial screening of

  12. Buckling Characteristics of Cylindrical Pipes

    Institute of Scientific and Technical Information of China (English)

    Toshiaki Sakurai

    2015-01-01

    This paper describes the buckling pattern of the body frame by energy absorbed efficiency of crashworthiness related toresearch of the buckling characteristics of aluminum cylindrical pipes with various diameters formed mechanical tools. Experimentswere performed by the quasi-static test without lubrication between specimen and equipment. According to the change in the radiusversus thickness of the specimen, the buckling phenomena are transformed from folding to bellows and the rate of energy absorptionis understood. In crashworthiness, frames are characterized by the folding among three patterns from the absorbed energy efficiencypoint of view and weight reduction. With the development of new types of transport such as electric vehicles, innovated bodystructure should be designed.

  13. Gills are an initial target of zinc oxide nanoparticles in oysters Crassostrea gigas, leading to mitochondrial disruption and oxidative stress

    Energy Technology Data Exchange (ETDEWEB)

    Trevisan, Rafael; Delapedra, Gabriel; Mello, Danielle F.; Arl, Miriam [Department of Biochemistry, Federal University of Santa Catarina, 88040-900 Florianópolis, SC (Brazil); Schmidt, Éder C. [Department of Cell Biology, Embryology and Genetic, Federal University of Santa Catarina, 88049-900 Florianópolis, SC (Brazil); Meder, Fabian; Monopoli, Marco [Centre for Bionano Interactions, University College Dublin, Dublin (Ireland); Cargnin-Ferreira, Eduardo [Federal Institute of Santa Catarina, Campus Garopaba, Laboratory of Histological Markers, 88495-000 Garopaba, SC (Brazil); Bouzon, Zenilda L. [Department of Cell Biology, Embryology and Genetic, Federal University of Santa Catarina, 88049-900 Florianópolis, SC (Brazil); Fisher, Andrew S. [School of Geography, Earth and Environmental Sciences, University of Plymouth, PL4 8AA Plymouth (United Kingdom); Sheehan, David [Department of Biochemistry, University College Cork, Cork (Ireland); Dafre, Alcir L., E-mail: alcir.dafre@ufsc.br [Department of Biochemistry, Federal University of Santa Catarina, 88040-900 Florianópolis, SC (Brazil)

    2014-08-15

    hemocyte count). At 24 h post exposure, decreased (−29%) glutathione reductase (GR) activity was observed in gills, but other biochemical responses were observed only after 48 h of exposure: lower GR activity (−28%) and levels of protein thiols (−21%), increased index of lipid peroxidation (+49%) and GPx activity (+26%). In accordance with ultrastructural changes and zinc load, digestive gland showed delayed biochemical responses. Except for a decreased GR activity (−47%) at 48 h post exposure, the biochemical alterations seen in gills were not present in digestive gland. The results indicate that gills are able to incorporate zinc prior (24 h) to digestive gland (48 h), leading to earlier mitochondrial disruption and oxidative stress. Our data suggest that gills are the initial target of ZnONP and that mitochondria are organelles particularly susceptible to ZnONP in C. gigas.

  14. KE-Rod Initial Velocity of Hollow Cylindrical Charge

    Directory of Open Access Journals (Sweden)

    Wang Shushan

    2011-01-01

    Full Text Available KE-rod warhead is a kind of forward interception warhead. To control the KE-rods to disperse uniformly, the hollow cylindrical charge is applied. Initial velocity is crucial to KE-rods distribution and the coordination between the fuze and the warhead. Therefore, based on the classical Gurney formula of cylindrical charge and tabulate interlayer charge, a mathematical model for calculating the KE-rod initial velocity of hollow cylindrical charge has been deduced based on certain assumptions, of which the basis theory is energy and momentum conservation. To validate this deduced equation, high-speed photography and metal-pass target experimental methods were applied simultaneously to test the initial velocity of designed KE-rod warhead. Testing results clearly indicate that the calculated results of the derived mathematical model coincides with the experimental  results, and with the increase in hollow radius, the calculated results become much closer to the experimental results. But the calculated results of classical Gurney formula are far above the experimental results, and the relative error increases with increase in the hollow diameter. The derived mathematical model with satisfactory accuracy is applicable to calculate the KE-rod initial velocity of hollow cylindrical charge in engineering applications.Defence Science Journal, 2011, 61(1, pp.25-29, DOI:http://dx.doi.org/10.14429/dsj.61.72

  15. Evaluation of transmitting performance of cylindrical polycapillary

    Science.gov (United States)

    Xiaoyan, Lin; Yude, Li; Guotai, Tan; Tianxi, Sun

    2007-03-01

    Based on a detailed ray-tracing code for capillary optics, a MATLAB program for the simulation of X-ray transmission in a cylindrical polycapillary is described. The simulated and experimental results for the spatial distributions and power density gain of the X-rays in the beam guided through a cylindrical polycapillary are in good agreement, and the results show that the spatial distribution of the X-rays in the beam guided through a cylindrical polycapillary is uneven.

  16. Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease.

    Science.gov (United States)

    Miniarikova, Jana; Zanella, Ilaria; Huseinovic, Angelina; van der Zon, Tom; Hanemaaijer, Evelyn; Martier, Raygene; Koornneef, Annemart; Southwell, Amber L; Hayden, Michael R; van Deventer, Sander J; Petry, Harald; Konstantinova, Pavlina

    2016-03-22

    Huntington's disease (HD) is a neurodegenerative disorder caused by accumulation of CAG expansions in the huntingtin (HTT) gene. Hence, decreasing the expression of mutated HTT (mtHTT) is the most upstream approach for treatment of HD. We have developed HTT gene-silencing approaches based on expression cassette-optimized artificial miRNAs (miHTTs). In the first approach, total silencing of wild-type and mtHTT was achieved by targeting exon 1. In the second approach, allele-specific silencing was induced by targeting the heterozygous single-nucleotide polymorphism (SNP) rs362331 in exon 50 or rs362307 in exon 67 linked to mtHTT. The miHTT expression cassette was optimized by embedding anti-HTT target sequences in ten pri-miRNA scaffolds and their HTT knockdown efficacy, allele selectivity, passenger strand activity, and processing patterns were analyzed in vitro. Furthermore, three scaffolds expressing miH12 targeting exon 1 were incorporated in an adeno-associated viral serotype 5 (AAV5) vector and their HTT knock-down efficiency and pre-miHTT processing were compared in the humanized transgenic Hu128/21 HD mouse model. Our data demonstrate strong allele-selective silencing of mtHTT by miSNP50 targeting rs362331 and total HTT silencing by miH12 both in vitro and in vivo. Ultimately, we show that HTT knock-down efficiency and guide strand processing can be enhanced by using different cellular pri-miRNA scaffolds.

  17. Identification of Novel Drug Targets and Lead Compounds for Advanced Prostate Cancer through Genomic and Cheminformatic Analyses

    Science.gov (United States)

    2015-08-01

    Med Res Rev 2013;33:1081–118. [18] Guo W, Burris TP, Zhang YH, Huang BL, Mason J, Copeland KC, et al. Genomic sequence of the DAX1 gene: an orphan...191] Maran RR, Thomas A, Roth M, Sheng Z, Esterly N, Pinson D, et al. Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial

  18. Volatile elements production rates in a 1.4 Gev proton-irradiated molten lead-bismuth target

    CERN Document Server

    Zanini, L; Everaerts, P; Fallot, M; Franberg, H; Gröschel, F; Jost, C; Kirchner, T; Kojima, Y; Köster, U; Lebenhaft, J; Manfrina, E; Pitcher, E J; Ravn, H L; Tall, Y; Wagner, W; Wohlmuther, M

    2005-01-01

    Production rates of volatile elements following spallation reaction of 1.4 GeV protons on a liquid Pb/Bi target have been measured. The experiment was performed at the ISOLDE facility at CERN. These data are of interest for the developments of targets for accelerator driven systems such as MEGAPIE. Additional data have been taken on a liquid Pb target. Calculations were performed using the FLUKA and MCNPX Monte Carlo codes coupled with the evolution codes ORIHET3 and FISPACT using different options for the intra-nuclear cascades and evaporation models. Preliminary results from the data analysis show good comparison with calculations for Hg and for noble gases. For other elements such as I it is apparent that only a fraction of the produced isotopes is released. The agreement with the experimental data varies depending on the model combination used. The best results are obtained using MCNPX with the INCL4/ABLA models and with FLUKA. Discrepancies are found for some isotopes produced by fission using the MCNPX ...

  19. An ISOLDE target unit

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    A good dozen different targets are available for ISOLDE, made of different materials and equipped with different kinds of ion-sources, according to the needs of the experiments. Each separator (GPS: general purpose; HRS: high resolution) has its own target. Because of the high radiation levels, robots effect the target changes, about 80 times per year. In the standard unit shown in picture _01, the target is the cylindrical object in the front. It contains uranium-carbide kept at a temperature of 2200 deg C, necessary for the isotopes to be able to escape. At either end, one sees the heater current leads, carrying 700 A. The Booster beam, some 3E13 protons per pulse, enters the target from left. The evaporated isotope atoms enter a hot-plasma ion source (the black object behind the target). The whole unit sits at 60 kV potential (pulsed in synchronism with the arrival of the Booster beam) which accelerates the ions (away from the viewer) towards one of the 2 separators.

  20. The Casimir Torque on a Cylindrical Gear

    CERN Document Server

    Vaidya, Varun

    2013-01-01

    We utilize Effective Field Theory(EFT) techniques to calculate the casimir torque on a cylindrical gear in the presence of a polarizable but neutral object. We present results for the energy and torque as a function of angle for a gear with multiple cogs, as well as for the case of a concentric cylindrical gear.

  1. Casimir torque on a cylindrical gear

    Science.gov (United States)

    Vaidya, Varun

    2014-08-01

    I utilize effective field theory(EFT) techniques to calculate the Casimir torque on a cylindrical gear in the presence of a polarizable but neutral object and present results for the energy and torque as a function of angle for a gear with multiple cogs, as well as for the case of a concentric cylindrical gear.

  2. Synthesis of Phased Cylindrical Arc Antenna Arrays

    Directory of Open Access Journals (Sweden)

    Hussein Rammal

    2009-01-01

    Full Text Available This paper describes a new approach to synthesize cylindrical antenna arrays controlled by the phase excitation, to synthesize directive lobe and multilobe patterns with steered zero. The proposed method is based on iterative minimization of a function that incorporates constraints imposed in each direction. An 8-element cylindrical antenna has been simulated and tested for various types of beam configurations.

  3. On cylindrical near-field scanning techniques

    DEFF Research Database (Denmark)

    Appel-Hansen, Jørgen

    1980-01-01

    The agreement between the coupling equations obtained in the literature by using the reciprocity theorem and the scattering matrix formulation is demonstrated. The field is expanded in cylindrical vector wave functions and the addition theorem for these functions is used. The communication may se...... serve as a tutorial introduction to the cylindrical scanning techniques....

  4. A Potential Model for Cylindrical Pores

    Institute of Scientific and Technical Information of China (English)

    张现仁; 汪文川

    2001-01-01

    An analytical potential for cylindrical pores has been derived by introducing a variational method into the integration for the calculation of the interaction energy between the wall molecules and a test molecule, all of which are represented by Lennard-Jones potential. The model proposed gives good fit to the results from the cylindrical surface model and the pseudoatom model. To test the potential proposed rigorously, we have carried out grand canonical ensemble Monte Carlo(GCMC) simulation of nitrogen in the MCM-41 pore at 77 K, and compared the simulated adsorption isotherm with the experimental data reported in the literature. The simulated isotherm from our model is in almost qualitative agreement with experiment. Consequently, the model proposed provides an explicit and accurate description of cylindrical pores represented by the Lennard-Jones potential. Moreover, the model can be easily applied to a variety of cylindrical pores, ranging from cylindrical surface to finite thickness walls, in both theoretical studies and computer simulations.

  5. Downregulation of chloroplast-targeted beta-amylase leads to a starch-excess phenotype in leaves

    DEFF Research Database (Denmark)

    Scheidig, A.; Fröhlich, A.; Schulze, S.;

    2002-01-01

    A functional screen in Escherichia coli was established to identify potato genes coding for proteins involved in transitory starch degradation. One clone isolated had a sequence very similar to a recently described chloroplast-targeted 5-amylase of Arabidopsis. Expression of the gene in E. coli...... showed that the protein product was a functional beta-amylase that could degrade both starch granules and solubilized amylopectin, while import experiments demonstrated that the beta-amylase was imported and processed into pea chloroplasts. To study the function of the protein in transitory starch...

  6. Return of target material ions leads to a reduced hysteresis in reactive high power impulse magnetron sputtering: Model

    Science.gov (United States)

    Kadlec, Stanislav; Čapek, Jiří

    2017-05-01

    A tendency to disappearing hysteresis in reactive High Power Impulse Magnetron Sputtering (HiPIMS) has been reported previously without full physical explanation. An analytical model of reactive pulsed sputtering including HiPIMS is presented. The model combines a Berg-type model of reactive sputtering with the global HiPIMS model of Christie-Vlček. Both time and area averaging is used to describe the macroscopic steady state, especially the reactive gas balance in the reactor. The most important effect in the presented model is covering of reacted parts of target by the returning ionized metal, effectively lowering the target coverage by reaction product at a given partial pressure. The return probability of ionized sputtered metal has been selected as a parameter to quantify the degree of HiPIMS effects. The model explains the reasons for reduced hysteresis in HiPIMS. The critical pumping speed was up to a factor of 7 lower in reactive HiPIMS compared to the mid-frequency magnetron sputtering. The model predicts reduced hysteresis in HiPIMS due to less negative slope of metal flux to substrates and of reactive gas sorption as functions of reactive gas partial pressure. Higher deposition rate of reactive HiPIMS compared to standard reactive sputtering is predicted for some parameter combinations. Comparison of the model with experiment exhibits good qualitative and quantitative agreement for three material combinations, namely, Ti-O2, Al-O2, and Ti-N2.

  7. Mechanistic validation of a clinical lead stapled peptide that reactivates p53 by dual HDM2 and HDMX targeting.

    Science.gov (United States)

    Wachter, F; Morgan, A M; Godes, M; Mourtada, R; Bird, G H; Walensky, L D

    2016-10-10

    Hydrocarbon-stapled peptides that display key residues of the p53 transactivation domain have emerged as bona fide clinical candidates for reactivating the tumor suppression function of p53 in cancer by dual targeting of the negative regulators HDM2 and HDMX. A recent study questioned the mechanistic specificity of such stapled peptides based on interrogating their capacity to disrupt p53/HDM2 and p53/HDMX complexes in living cells using a new recombinase enhanced bimolecular luciferase complementation platform (ReBiL). Here, we directly evaluate the cellular uptake, intracellular targeting selectivity and p53-dependent cytotoxicity of the clinical prototype ATSP-7041. We find that under standard serum-containing tissue culture conditions, ATSP-7041 achieves intracellular access without membrane disruption, dose-dependently dissociates both p53/HDM2 and p53/HDMX complexes but not an unrelated protein complex in long-term ReBiL experiments, and is selectively cytotoxic to cancer cells bearing wild-type p53 by inducing a surge in p53 protein level. These studies underscore the importance of a thorough stepwise approach, including consideration of the time-dependence of cellular uptake and intracellular distribution, in evaluating and advancing stapled peptides for clinical translation.Oncogene advance online publication, 10 October 2016; doi:10.1038/onc.2016.361.

  8. H-CRRETAWAC-OH, a Lead Structure for the Development of Radiotracer Targeting Integrin α5β1?

    Directory of Open Access Journals (Sweden)

    Roland Haubner

    2014-01-01

    Full Text Available Imaging of angiogenic processes is of great interest in preclinical research as well as in clinical settings. The most commonly addressed target structure for imaging angiogenesis is the integrin αvβ3. Here we describe the synthesis and evaluation of [18F]FProp-Cys*-Arg-Arg-Glu-Thr-Ala-Trp-Ala-Cys*-OH, a radiolabelled peptide designed to selectively target the integrin α5β1. Conjugation of 4-nitrophenyl-(RS-2-[18F]fluoropropionate provided [18F]FProp-Cys*-Arg-Arg-Glu-Thr-Ala-Trp-Ala-Cys*-OH in high radiochemical purity (>95% and a radiochemical yield of approx. 55%. In vitro evaluation showed α5β1 binding affinity in the nanomolar range, whereas affinity to αvβ3 and αIIbβ3 was >50 μM. Cell uptake studies using human melanoma M21 (αvβ3-positive and α5β1-negative, human melanoma M21-L (αvβ3-negative and α5β1-negative, and human prostate carcinoma DU145 (αvβ3-negative and α5β1-positive confirmed receptor-specific binding. The radiotracer was stable in human serum and showed low protein binding. Biodistribution studies showed tumour uptake ranging from 2.5 to 3.5% ID/g between 30 and 120 min post-injection. However, blocking studies and studies using mice bearing α5β1-negative M21 tumours did not confirm receptor-specific uptake of [18F]FProp-Cys*-Arg-Arg-Glu-Thr-Ala-Trp-Ala-Cys*-OH, although this radiopeptide revealed high affinity and substantial selectivity to α5β1 in vitro. Further experiments are needed to study the in vivo metabolism of this peptide and to develop improved radiopeptide candidates suitable for PET imaging of α5β1 expression in vivo.

  9. Shielding and Radiation Characteristics of Cylindrical Layered Bianisotropic Structures

    Directory of Open Access Journals (Sweden)

    A. Toscano

    2005-12-01

    Full Text Available In this paper we propose an analytical study in the spectral domainof cylindrical layered structures filled with general bianisotropicmedia and fed by a 3D electric source. The integrated structure ischaracterized in terms of transmission matrices leading to anequivalent circuit representation of the whole multilayered structure.Within the framework of this two-port formalism, we present a newcontribution to the computation of the Green's function arising in theanalysis of multilayered conformal integrated antennas loaded withgeneral bianisotropic materials. We also propose an analytical study ofthe shielding effectiveness of general bianisotropic materials locatedin multilayered, cylindrical configuration. The expression of theshielded fields sustained both by plane wave and arbitrary sources isobtained in a closed analytical form. Numerical results are alsopresented showing effects of electromagnetic parameters on radiationpattern, matching properties and radar cross section of the integratedstructure.

  10. Cylindrical luminescent solar concentrators with near-infrared quantum dots.

    Science.gov (United States)

    Inman, R H; Shcherbatyuk, G V; Medvedko, D; Gopinathan, A; Ghosh, S

    2011-11-21

    We investigate the performance of cylindrical luminescent solar concentrators (CLSCs) with near-infrared lead sulfide quantum dots (QDs) in the active region. We fabricate solid and hollow cylinders from a composite of QDs in polymethylmethacrylate, prepared by radical polymerization, and characterize sample homogeneity and optical properties using spectroscopic techniques. We additionally measure photo-stability and photocurrent outputs under both laboratory and external ambient conditions. The experimental results are in good agreement with theoretical calculations which demonstrate that the hollow CLSCs have higher absorption of incident radiation and lower self-absorption compared to solid cylindrical and planar geometries with similar geometric factors, resulting in a higher optical efficiency. © 2011 Optical Society of America

  11. Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development

    Directory of Open Access Journals (Sweden)

    Charu Sharma

    2015-01-01

    Full Text Available The cannabinoid molecules are derived from Cannabis sativa plant which acts on the cannabinoid receptors types 1 and 2 (CB1 and CB2 which have been explored as potential therapeutic targets for drug discovery and development. Currently, there are numerous cannabinoid based synthetic drugs used in clinical practice like the popular ones such as nabilone, dronabinol, and Δ9-tetrahydrocannabinol mediates its action through CB1/CB2 receptors. However, these synthetic based Cannabis derived compounds are known to exert adverse psychiatric effect and have also been exploited for drug abuse. This encourages us to find out an alternative and safe drug with the least psychiatric adverse effects. In recent years, many phytocannabinoids have been isolated from plants other than Cannabis. Several studies have shown that these phytocannabinoids show affinity, potency, selectivity, and efficacy towards cannabinoid receptors and inhibit endocannabinoid metabolizing enzymes, thus reducing hyperactivity of endocannabinoid systems. Also, these naturally derived molecules possess the least adverse effects opposed to the synthetically derived cannabinoids. Therefore, the plant based cannabinoid molecules proved to be promising and emerging therapeutic alternative. The present review provides an overview of therapeutic potential of ligands and plants modulating cannabinoid receptors that may be of interest to pharmaceutical industry in search of new and safer drug discovery and development for future therapeutics.

  12. Cylindrical air flow reversal barrier

    Energy Technology Data Exchange (ETDEWEB)

    Woznica, C.; Rodziewicz, M.

    1988-06-01

    Describes an innovative design introduced in the ZMP mine in Zory for quick reversal of ventilation air flow. Geologic mining conditions at the 705 m deep horizon, where the barrier was built, are described. According to the design used until now, a reversal system consisted of safety barriers, ventilation air locks, a ventilation bridge and stopping needed in case of a fire when air flow direction must be reversed. Nine air locks and an expensive concrete ventilation bridge were needed and the air locks had to be operated at 8 points of the region to effect reversal. The new design consists of a 2-storey cylindrical barrier which also fulfills the function of a ventilation bridge. It can be manually or remotely operated by a mechanical or pneumatic system. Tests showed that the new barrier permits immediate air flow reversal while retaining 60% of the original air, which is important in the case of fire and methane hazards. It permits improved seam panelling and splitting of pillars and brings an economy of about 40 million zlotys in construction cost. Design and operation of the barrier is illustrated and ventilation air circulation is explained. 7 figs.

  13. Acoustic transfer admittance of cylindrical cavities

    Science.gov (United States)

    Guianvarc'h, C.; Durocher, J.-N.; Bruneau, M.; Bruneau, A.-M.

    2006-05-01

    The reciprocity calibration method uses two microphones acoustically connected by a coupler, a cylindrical cavity closed at each end by the diaphragms of the transmitting and receiving microphones. The acoustic transfer admittance of the coupler, including the thermal conductivity effect of the fluid, must be modelled precisely to obtain the accurate sensitivity of the microphones from the electrical transfer impedance measurement. It appears that the analytical model quoted in the current standard [International Electrotechnical Commission IEC 61064-2, Measurement Microphones, Part 2: Primary Method for Pressure Calibration of Laboratory Standard Microphones by the Reciprocity Technique, 1992] is not the appropriate one and that it should be revised, as also suggested by a recent EUROMET project report [K. Rasmussen, Datafiles simulating a pressure reciprocity calibration of microphones, EUROMET Project 294 Report PL-13, 2001]. Thus, it is the aim of the paper to investigate analytically the acoustic field inside the coupler, revisiting the assumptions of the earlier work, leading to a coherent description and therefore providing clarity which should facilitate discussion of a possible revised standard.

  14. On the incompressibility of cylindrical origami patterns

    CERN Document Server

    Bös, Friedrich; Gottesman, Omer; Wardetzky, Max

    2015-01-01

    We investigate the axial compressibility of origami cylinders, i.e., cylindrical structures folded from rectangular sheets of paper. We prove, using geometric arguments, that a general fold pattern only allows for a finite number of isometric cylindrical embeddings. Therefore, compressibility of such structures requires stretching the material or deforming the folds. Our result complements the celebrated "bellows theorem" and extends it to the setting of cylindrical origami whose top and bottom are not necessarily rigid, and severely restricts the space of constructions that must be searched when designing new types of origami-based rigid-foldable deployable structures and metamaterials.

  15. An Insoluble Titanium-Lead Anode for Sulfate Electrolytes

    Energy Technology Data Exchange (ETDEWEB)

    Ferdman, Alla

    2005-05-11

    The project is devoted to the development of novel insoluble anodes for copper electrowinning and electrolytic manganese dioxide (EMD) production. The anodes are made of titanium-lead composite material produced by techniques of powder metallurgy, compaction of titanium powder, sintering and subsequent lead infiltration. The titanium-lead anode combines beneficial electrochemical behavior of a lead anode with high mechanical properties and corrosion resistance of a titanium anode. In the titanium-lead anode, the titanium stabilizes the lead, preventing it from spalling, and the lead sheathes the titanium, protecting it from passivation. Interconnections between manufacturing process, structure, composition and properties of the titanium-lead composite material were investigated. The material containing 20-30 vol.% of lead had optimal combination of mechanical and electrochemical properties. Optimal process parameters to manufacture the anodes were identified. Prototypes having optimized composition and structure were produced for testing in operating conditions of copper electrowinning and EMD production. Bench-scale, mini-pilot scale and pilot scale tests were performed. The test anodes were of both a plate design and a flow-through cylindrical design. The cylindrical anodes were composed of cylinders containing titanium inner rods and fitting over titanium-lead bushings. The cylindrical design allows the electrolyte to flow through the anode, which enhances diffusion of the electrolyte reactants. The cylindrical anodes demonstrate higher mass transport capabilities and increased electrical efficiency compared to the plate anodes. Copper electrowinning represents the primary target market for the titanium-lead anode. A full-size cylindrical anode performance in copper electrowinning conditions was monitored over a year. The test anode to cathode voltage was stable in the 1.8 to 2.0 volt range. Copper cathode morphology was very smooth and uniform. There was no

  16. Radiochemical determination of {sup 129}I and {sup 36}Cl in MEGAPIE, a proton irradiated lead-bismuth eutectic spallation target

    Energy Technology Data Exchange (ETDEWEB)

    Hammer-Rotzler, Bernadette; Tuerler, Andreas [Paul Scherrer Institut (PSI), Villigen (Switzerland); Bern Univ. (Switzerland); Neuhausen, Joerg; Boutellier, Viktor; Wohlmuther, Michael; Schumann, Dorothea [Paul Scherrer Institut (PSI), Villigen (Switzerland); Vockenhuber, Christof [ETH Zurich (Switzerland). Lab. of Ion Beam Physics

    2015-07-01

    The concentrations of the long-lived nuclear reaction products {sup 129}I and {sup 36}Cl have been measured in samples from the MEGAPIE liquid metal spallation target. Samples from the bulk target material (lead-bismuth eutectic, LBE), from the interface of the metal free surface with the cover gas, from LBE/steel interfaces and from noble metal absorber foils installed in the cover gas system were analysed using Accelerator Mass Spectrometry at the Laboratory of Ion beam Physics at ETH Zuerich. The major part of {sup 129}I and {sup 36}Cl was found accumulated on the interfaces, particularly at the interface of LBE and the steel walls of the target container, while bulk LBE samples contain only a minor fraction of these nuclides. Both nuclides were also detected on the absorber foils to a certain extent (<< 1% of the total amount). The latter number is negligible concerning the radio-hazard of the irradiated target material; however it indicates a certain affinity of the absorber foils for halogens, thus proving the principle of using noble metal foils for catching these volatile radionuclides. The total amounts of {sup 129}I and {sup 36}Cl in the target were estimated from the analytical data by averaging within the different groups of samples and summing up these averages over the total target. This estimation could account for about half of the amount of {sup 129}I and {sup 36}Cl predicted to be produced using nuclear physics modelling codes for both nuclides. The significance of the results and the associated uncertainties are discussed.

  17. Vibration control of cylindrical shells using active constrained layer damping

    Science.gov (United States)

    Ray, Manas C.; Chen, Tung-Huei; Baz, Amr M.

    1997-05-01

    The fundamentals of controlling the structural vibration of cylindrical shells treated with active constrained layer damping (ACLD) treatments are presented. The effectiveness of the ACLD treatments in enhancing the damping characteristics of thin cylindrical shells is demonstrated theoretically and experimentally. A finite element model (FEM) is developed to describe the dynamic interaction between the shells and the ACLD treatments. The FEM is used to predict the natural frequencies and the modal loss factors of shells which are partially treated with patches of the ACLD treatments. The predictions of the FEM are validated experimentally using stainless steel cylinders which are 20.32 cm in diameter, 30.4 cm in length and 0.05 cm in thickness. The cylinders are treated with ACLD patches of different configurations in order to target single or multi-modes of lobar vibrations. The ACLD patches used are made of DYAD 606 visco-elastic layer which is sandwiched between two layers of PVDF piezo-electric films. Vibration attenuations of 85% are obtained with maximum control voltage of 40 volts. Such attenuations are attributed to the effectiveness of the ACLD treatment in increasing the modal damping ratios by about a factor of four over those of conventional passive constrained layer damping (PCLD) treatments. The obtained results suggest the potential of the ACLD treatments in controlling the vibration of cylindrical shells which constitute the major building block of many critical structures such as cabins of aircrafts, hulls of submarines and bodies of rockets and missiles.

  18. Measurements of spallation neutrons from a thick lead target bombarded with 0.5 and 1.5 GeV protons

    Energy Technology Data Exchange (ETDEWEB)

    Meigo, Shin-ichiro; Takada, Hiroshi; Chiba, Satoshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment] [and others

    1997-03-01

    Double differential neutron spectra from a thick lead target bombarded with 0.5 and 1.5 GeV protons have been measured with the time-of-flight technique. In order to obtain the neutron spectra without the effect of the flight time fluctuation by neutron scattering in the target, an unfolding technique has also been employed in the low energy region below 3 MeV. The measured data have been compared with the calculated results of NMTC/JAERI-MCNP-4A code system. It has been found that the code system gives about 50 % lower neutron yield than the experimental ones in the energy region between 20 and 80 MeV for both incident energies. The disagreements, however, have been improved well by taking account of the inmedium nucleon-nucleon scattering cross sections in the NMTC/JAERI code. (author)

  19. Target identification, lead optimization and antitumor evaluation of some new 1,2,4-triazines as c-Met kinase inhibitors.

    Science.gov (United States)

    El-Wakil, Marwa H; Ashour, Hayam M; Saudi, Manal N; Hassan, Ahmed M; Labouta, Ibrahim M

    2017-08-01

    In silico target fishing approach using PharmMapper server identified c-Met kinase as the selective target for our previously synthesized compound NCI 748494/1. This approach was validated by in vitro kinase assay which showed that NCI 748494/1 possessed promising inhibitory activity against c-Met kinase (IC50=31.70μM). Assessment of ADMET profiling, drug-likeness, drug score as well as docking simulation for the binding pose of that compound in the active site of c-Met kinase domain revealed that NCI 748494/1 could be considered as a promising drug lead. Based on target identification and validation, it was observed that there is structure similarity between NCI 748494/1 and the reported type II c-Met kinase inhibitor BMS-777607. Optimization of our lead NCI 748494/1 furnished newly synthesized 1,2,4-triazine derivatives based on well-established structure-activity relationships, whereas three compounds namely; 4d, 7a and 8c displayed excellent in vitro cytotoxicity against three c-Met addicted cancer cell lines; A549 (lung adenocarcinoma), HT-29 (colon cancer) and MKN-45 (gastric carcinoma); with IC50 values in the range 0.01-1.86µM. In vitro c-Met kinase assay showed 8c to possess the highest c-Met kinase inhibition profile (IC50=4.31µM). Docking of the active compounds in c-Met kinase active site revealed strong binding interactions comparable to the lead NCI 748494/1 and BMS-777607, suggesting that c-Met inhibition is very likely to be the mechanism of the antitumor effect of these derivatives. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Review and research analysis of computational target methods using BioRuby and in silico screening of herbal lead compounds against pancreatic cancer using R programming.

    Science.gov (United States)

    Jayadeepa, R M; Ray, Ankita; Naik, Dhaval; Sanyal, Debendra Nath; Shah, Disha

    2014-01-01

    Plants and their natural components sophisticated with the cornerstone of traditional conventional medicinal system throughout the globe for many years and extend to furnish mankind with latest remedies. Natural Products act as lead molecules for the synthesis of various potent drugs. In the current research a study is conducted on herbal small molecule and their potential binding chemical affinity to the effect or molecules of major diseases such as pancreatic cancer. Clinical studies demonstrate correlation between Cyclin- Dependent Kinase 4 (CDK4) and malignant progression of Pancreatic Cancer. Using Bioruby Gem's we were able to analyze better characteristics of the target protein. VegaZZ and NAMD were used to minimize the energy of the target protein. Therefore identification of effective, well- tolerated targets was analyzed. Further the target protein was subjected to docking with the anti cancer inhibitors which represents a rational chemo preventive strategy using AutoDock Vina. Later using the dock score top ranked phytochemicals were analyzed for Toxicity Analysis. Using the BioRuby gem we were able to measure the distance between the amino acid. Various R scripting libraries were used to hunt the best leads, as in this case the phytochemicals. Phytochemicals such as Wedelolactones and Catechin were analyzed computationally. This study has presented the various effects of naturally occurring anti pancreatic cancer compounds Catechin, Wedelolactones that inhibits Cyclin Dependent Kinase 4. The study results reveal that compounds use less binding energy to CDK4 and inhibit its activity. Future investigation of other various wet lab studies such as cell line studies will confirm results of these two herbal chemical formulations potential ones for treating Pancreatic Cancer.

  1. Cylindrical-shaped nanotube field effect transistor

    KAUST Repository

    Hussain, Muhammad Mustafa

    2015-12-29

    A cylindrical-shaped nanotube FET may be manufactured on silicon (Si) substrates as a ring etched into a gate stack and filled with semiconductor material. An inner gate electrode couples to a region of the gate stack inside the inner circumference of the ring. An outer gate electrode couples to a region of the gate stack outside the outer circumference of the ring. The multi-gate cylindrical-shaped nanotube FET operates in volume inversion for ring widths below 15 nanometers. The cylindrical-shaped nanotube FET demonstrates better short channel effect (SCE) mitigation and higher performance (I.sub.on/I.sub.off) than conventional transistor devices. The cylindrical-shaped nanotube FET may also be manufactured with higher yields and cheaper costs than conventional transistors.

  2. View factors of cylindrical spiral surfaces

    Science.gov (United States)

    Lebedev, Vladimir A.; Solovjov, Vladimir P.

    2016-03-01

    Analytical expressions are presented for the view factors (radiative configuration factors) associated with the flat right cylindrical spiral surface. Such cylindrical spiral systems are widely applied as electrical resistance heating elements for lighting devices, electronic radio tubes, high-speed gas flow heaters, and other appliances used for scientific, industrial and domestic purposes. Derivation of the view factors is based on the invariant principles and the results presented in Lebedev (2000, 2003,1988) [1-3].

  3. Pathways for the release of polonium from a lead-bismuth spallation target (thermochemical calculation); Verfluechtigungspfade des Poloniums aus einem Pb-Bi-Spallationstarget (Thermochemische Kalkulation)

    Energy Technology Data Exchange (ETDEWEB)

    Eichler, B.; Neuhausen, J

    2004-06-01

    An analysis of literature data for the thermochemical constants of polonium reveals considerable discrepancies in the relations of these data among each other as well as in their expected trends within the chalcogen group. This fact hinders a reliable assessment of possible reaction paths for the release of polonium from a liquid lead-bismuth spallation target. In this work an attempt is made to construct a coherent data set for the thermochemical properties of polonium and some of its compounds that are of particular importance with respect to the behaviour of polonium in a liquid Pb-Bi target. This data set is based on extrapolations using general trends throughout the periodic table and, in particular, within the chalcogen group. Consequently, no high accuracy should be attributed to the derived data set. However, the data set derived in this work is consistent with definitely known experimental data. Furthermore, it complies with the general trends of physicochemical properties within the chalcogen group. Finally, well known relations between thermochemical quantities are fulfilled by the data derived in this work. Thus, given the lack of accurate experimental data it can be regarded as best available data. Thermochemical constants of polonium hydride, lead polonide and polonium dioxide are derived based on extrapolative procedures. Furthermore, the possibility of formation of the gaseous intermetallic molecule BiPo, which has been omitted from discussion up to now, is investigated. From the derived thermochemical data the equilibrium constants of formation, release and dissociation reactions are calculated for different polonium containing species. Furthermore equilibrium constants are determined for the reaction of lead polonide and polonium dioxide with hydrogen, water vapour and the target components lead and bismuth. The most probable release pathways are discussed. From thermochemical evaluations polonium is expected to be released from liquid lead

  4. Cylindrical Helix Spline Approximation of Spatial Curves

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In this paper, we present a new method for approximating spatial curves with a G1 cylindrical helix spline within a prescribed tolerance. We deduce the general formulation of a cylindrical helix,which has 11 freedoms. This means that it needs 11 restrictions to determine a cylindrical helix. Given a spatial parametric curve segment, including the start point and the end point of this segment, the tangent and the principal normal of the start point, we can always find a cylindrical segment to interpolate the given direction and position vectors. In order to approximate the known parametric curve within the prescribed tolerance, we adopt the trial method step by step. First, we must ensure the helix segment to interpolate the given two end points and match the principal normal and tangent of the start point, and then, we can keep the deviation between the cylindrical helix segment and the known curve segment within the prescribed tolerance everywhere. After the first segment had been formed, we can construct the next segment. Circularly, we can construct the G1 cylindrical helix spline to approximate the whole spatial parametric curve within the prescribed tolerance. Several examples are also given to show the efficiency of this method.

  5. Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells.

    Science.gov (United States)

    Yang, Xu; Wang, Dapeng; Ma, Yuan; Xu, Xiguo; Zhu, Zhen; Wang, Xiaojuan; Deng, Hanyi; Li, Chunchun; Chen, Min; Tong, Jian; Yamanaka, Kenzo; An, Yan

    2015-12-01

    Long-term exposure to arsenite leads to human lung cancer, but the underlying mechanisms of carcinogenesis remain obscure. The transcription factor of nuclear factor-erythroid-2 p45-related factor (Nrf2)-mediated antioxidant response represents a critical cellular defense mechanism and protection against various diseases. Paradoxically, emerging data suggest that the constitutive activation of Nrf2 is associated with cancer development, progression and chemotherapy resistance. However, the role of Nrf2 in the occurrence of cancer induced by long-term arsenite exposure remains to be fully understood. By establishing transformed human bronchial epithelial (HBE) cells via chronic low-dose arsenite treatment, we showed that, in acquiring this malignant phenotype, continuous low level of ROS and sustained enhancement of Nrf2 and its target antioxidant enzyme levels were observed in the later-stage of arsenite-induced cell transformation. The downregulation of Keap1 level may be responsible for the over-activation of Nrf2 and its target enzymes. To validate these observations, Nrf2 was knocked down in arsenite-transformed HBE cells by SiRNA transfection, and the levels of Nrf2 and its target antioxidant enzymes, ROS, cell proliferation, migration, and colony formation were determined following these treatments. Results showed that blocked Nrf2 expression significantly reduced Nrf2 and its target antioxidant enzyme levels, restored ROS levels, and eventually suppressed cell proliferation, migration, and colony formation of the transformed cells. In summary, the results of the study strongly suggested that the continuous activation of Nrf2 and its target antioxidant enzymes led to the over-depletion of intracellular ROS levels, which contributed to arsenite-induced HBE cell transformation. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Magnetic forces between arrays of cylindrical permanent magnets

    DEFF Research Database (Denmark)

    Vokoun, D.; Tomassetti, G.; Beleggia, Marco

    2011-01-01

    Permanent magnet arrays are often employed in a broad range of applications: actuators, sensors, drug targeting and delivery systems, fabrication of self-assembled particles, just to name a few. An estimate of the magnetic forces in play between arrays is required to control devices and fabrication...... procedures. Here, we introduce analytical expressions for calculating the attraction force between two arrays of cylindrical permanent magnets and compare the predictions with experimental data obtained from force measurements with NdFeB magnets. We show that the difference between predicted and measured...

  7. ANALYSIS OF TRANSIENT THERMAL STRESS IN CYLINDRICALLY ORTHOTROPIC TUBES

    Institute of Scientific and Technical Information of China (English)

    凌道盛

    2003-01-01

    The incorrect deduction of equations in the research works devoted to the studies of transient stress in cylindrically orthotropic tubes and done by Kardomateas ( Journal of Applied Mechanics, 1989, 1990) leads to the wrong results. The errata (1991) correct the deduction error, but do not give the right numerical results. All errors are corrected, and the Mathematica is adopted to solve the large argument problem for Bessel function. A theoretical solution of the transient thermal stresses in tubes with uniform form is presented,and a numerical example is studied.

  8. Independence-friendly cylindric set algebras

    CERN Document Server

    Mann, Allen L

    2007-01-01

    Independence-friendly logic is a conservative extension of first-order logic that has the same expressive power as existential second-order logic. In her Ph.D. thesis, Dechesne introduces a variant of independence-friendly logic called IFG logic. We attempt to algebraize IFG logic in the same way that Boolean algebra is the algebra of propositional logic and cylindric algebra is the algebra of first-order logic. We define independence-friendly cylindric set algebras and prove two main results. First, every independence-friendly cylindric set algebra over a structure has an underlying Kleene algebra. Moreover, the class of such underlying Kleene algebras generates the variety of all Kleene algebras. Hence the equational theory of the class of Kleene algebras that underly an independence-friendly cylindric set algebra is finitely axiomatizable. Second, every one-dimensional independence-friendly cylindric set algebra over a structure has an underlying monadic Kleene algebra. However, the class of such underlyin...

  9. Lead Optimization of 2-Cyclohexyl-N-[(Z-(3-methoxyphenyl/3-hydroxyphenyl methylidene]hydrazinecarbothioamides for Targeting the HER-2 Overexpressed Breast Cancer Cell Line SKBr-3

    Directory of Open Access Journals (Sweden)

    Mashooq A. Bhat

    2015-10-01

    Full Text Available Lead derivatives of 2-cyclohexyl-N-[(Z-(3-methoxyphenyl/3-hydroxyphenyl methylidene]hydrazinecarbothioamides 1–18 were synthesized, characterized and evaluated in vitro against HER-2 overexpressed breast cancer cell line SKBr-3. All the compounds showed activity against HER-2 overexpressed SKBr-3 cells with IC50 = 17.44 ± 0.01 µM to 53.29 ± 0.33 µM. (2Z-2-(3-Hydroxybenzylidene-N-(3-methoxyphenylhydrazinecarbothioamide (12, IC50 = 17.44 ± 0.01 µM was found to be most potent compound of this series targeting HER-2 overexpressed breast cancer cells compared to the standard drug 5-fluorouracil (5-FU (IC50 = 38.58 ± 0.04 µM. Compound 12 inhibited the cellular proliferation via DNA degradation.

  10. Electronic Quantum Confinement in Cylindrical Potential Well

    CERN Document Server

    Baltenkov, A S

    2016-01-01

    The effects of quantum confinement on the momentum distribution of electrons confined within a cylindrical potential well have been analyzed. The motivation is to understand specific features of the momentum distribution of electrons when the electron behavior is completely controlled by the parameters of a non-isotropic potential cavity. It is shown that studying the solutions of the wave equation for an electron confined in a cylindrical potential well offers the possibility to analyze the confinement behavior of an electron executing one- or two-dimensional motion in the three-dimensional space within the framework of the same mathematical model. Some low-lying electronic states with different symmetries have been considered and the corresponding wave functions have been calculated; the behavior of their nodes and their peak positions with respect to the parameters of the cylindrical well has been analyzed. Additionally, the momentum distributions of electrons in these states have been calculated. The limi...

  11. Cylindrical electrochemical cells with a diaphragm seal

    Energy Technology Data Exchange (ETDEWEB)

    Georgopoulos, P.

    1993-07-13

    A cylindrical electrochemical cell is described comprising an anode, a cathode and electrolyte contained in a cylindrical container, the container having an open end and a closed end; wherein the open end of the container is sealed with a seal assembly comprising: (a) a disc-shaped seal member, made from an electrically insulative material, having an outer edge wall connected via a base to a centrally located cylindrical hub that defines an orifice; which base has a ventable diaphragm portion and a nonventable diaphragm portion that is thicker than the ventable diaphragm portion; and wherein the ventable diaphragm portion joins the hub at an interface and becomes gradually thicker in the direction away from the interface toward the outer edge wall so that the ventable diaphragm portion is thinnest at the interface; and (b) a current collector extending through the orifice defined by the hub into the cell's interior to contact one of the cell's electrodes.

  12. Cylindrical polarization symmetry for nondestructive nanocharacterization

    Science.gov (United States)

    Zhan, Qiwen

    2003-07-01

    Recently there is an increasing interest in laser beams with radial symmetry in polarization. Due to the cylindrical symmetry in polarization, these beams have unique focusing properties, which may find wide applications in a variety of nanometer scale applications, including high-resolution metrology, high-density data storage, and multi-functional optical microtool. In this paper, simple method of generating cylindrically polarized beams is presented and their potential applications to nondestructive nano-characterization are discussed. A high resolution surface plasmon microscope and a surface plasmon enhanced apertureless near-field scanning optical microscope are proposed. An automatic scanning microellipsometer that uses the cylindrical symmetry to enhance the signal-to-noise-ratio in high-spatial-resolution ellipsometric measurement will also be presented.

  13. Research on cylindrical shell vibration reduction systems

    Institute of Scientific and Technical Information of China (English)

    XING Xiao-liang; WANG Min-qing

    2008-01-01

    Longitudinal and horizontal vibration must both be reduced in an effective vibration isolation system. We present a cylindrical shell vibration isolator as a dynamic system composed of four springs and dampers. Vibration is directly produced by the motion of machinery, and more is subsequently generated by harmonic frequencies within their structure. To test the effectiveness of our isolator, we first determined equations for the transmission of vibration from the machine to its cylindrical shell. Damping effects produced by the vibration parameters of our system are then analyzed.

  14. DISPERSION OF CYLINDRICAL PARTICLES IN TURBULENT FLOWS

    Institute of Scientific and Technical Information of China (English)

    GAO Zhen-yu; LIN Jian-zhong

    2004-01-01

    With consideration of the Stokes drag and virtual mass force, the equations for mean and fluctuating velocities in rotation and translation were given for rigid cylindrical particles moving in a turbulent flow. Then the rotational and translational dispersion coefficients of particle were derived. The relationships between the dispersion coefficients and flow length scale as well as particle characteristic parameters were analyzed. The resulting dispersion coefficients were proved to decrease as the particle length increases. The conclusions are helpful for the further research on the motion of cylindrical particles in turbulent flows.

  15. Stability of generic cylindrical thin shell wormholes

    CERN Document Server

    Mazharimousavi, S Habib; Amirabi, Z

    2014-01-01

    We revisit the stability analysis of cylindrical thin shell wormholes which have been studied in literature so far. Our approach is more systematic and in parallel to the method which is used in spherically symmetric thin shell wormholes. The stability condition is summarized as the positivity of the second derivative of an effective potential at the equilibrium radius, i.e. $V^{\\prime \\prime}\\left(a_{0}\\right) >0$. This may serve as the master equation in all stability problems for the cylindrical thin-shell wormholes.

  16. RESONANCE RADIATION OF SUBMERGED INFINITE CYLINDRICAL SHELL

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The resonance sound radiation from submerged infinite elastic cylindrical shell, excited by internal harmonic line force, is investigated. The shell radiation power is presented in terms of resonant modal radiation derived from resonance radiation theory (RRT). The resonance radiation formulae are derived from classical Rayleigh normal mode solution, which are useful for understanding the mechanism of sound radiation from submerged shells. As an example, numerical calculation of a thin steel cylindrical shell is done by using these two methods. It seems that the results of RRT solutions are in good agreement with that of Rayleigh normal mode solutions.

  17. Static cylindrical symmetry and conformal flatness

    CERN Document Server

    Herrera, L; Marcilhacy, G; Santos, N O

    2004-01-01

    We present the whole set of equations with regularity and matching conditions required for the description of physically meaningful static cylindrically symmmetric distributions of matter, smoothly matched to Levi-Civita vacuum spacetime. It is shown that the conformally flat solution with equal principal stresses represents an incompressible fluid. It is also proved that any conformally flat cylindrically symmetric static source cannot be matched through Darmois conditions to the Levi-Civita spacetime. Further evidence is given that when the Newtonian mass per unit length reaches 1/2 the spacetime has plane symmetry.

  18. POLARON IN CYLINDRICAL AND SPHERICAL QUANTUM DOTS

    Directory of Open Access Journals (Sweden)

    L.C.Fai

    2004-01-01

    Full Text Available Polaron states in cylindrical and spherical quantum dots with parabolic confinement potentials are investigated applying the Feynman variational principle. It is observed that for both kinds of quantum dots the polaron energy and mass increase with the increase of Frohlich electron-phonon coupling constant and confinement frequency. In the case of a spherical quantum dot, the polaron energy for the strong coupling is found to be greater than that of a cylindrical quantum dot. The energy and mass are found to be monotonically increasing functions of the coupling constant and the confinement frequency.

  19. Micromagnetic simulations of cylindrical magnetic nanowires

    KAUST Repository

    Ivanov, Yurii P.

    2015-05-27

    This chapter reviews micromagnetic simulations of cylindrical magnetic nanowires and their ordered arrays. It starts with a description of the theoretical background of micromagnetism. The chapter discusses main magnetization reversal modes, domain wall types, and state diagrams in cylindrical nanowires of different types and sizes. The results of the hysteresis process in individual nanowires and nanowire arrays also are presented. Modeling results are compared with experimental ones. The chapter also discusses future trends in nanowire applications in relation to simulations, such as current-driven dynamics, spintronics, and spincaloritronics. The main micromagnetic programs are presented and discussed, together with the corresponding links.

  20. Ecotoxicology: Lead

    Science.gov (United States)

    Scheuhammer, A.M.; Beyer, W.N.; Schmitt, C.J.; Jorgensen, Sven Erik; Fath, Brian D.

    2008-01-01

    Lead (Pb) is a naturally occurring metallic element; trace concentrations are found in all environmental media and in all living things. However, certain human activities, especially base metal mining and smelting; combustion of leaded gasoline; the use of Pb in hunting, target shooting, and recreational angling; the use of Pb-based paints; and the uncontrolled disposal of Pb-containing products such as old vehicle batteries and electronic devices have resulted in increased environmental levels of Pb, and have created risks for Pb exposure and toxicity in invertebrates, fish, and wildlife in some ecosystems.

  1. Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer’s drugs: a computational investigation

    Directory of Open Access Journals (Sweden)

    Azam F

    2014-10-01

    Full Text Available Faizul Azam,1,2 Abdualrahman M Amer,1 Abdullah R Abulifa,1 Mustafa M Elzwawi1 1Faculty of Pharmacy, Misurata University, Misurata, Libya; 2Department of Pharmaceutical Chemistry, Nims Institute of Pharmacy, Nims University, Jaipur, Rajasthan, India Abstract: Ginger (Zingiber officinale, despite being a common dietary adjunct that contributes to the taste and flavor of foods, is well known to contain a number of potentially bioactive phytochemicals having valuable medicinal properties. Although recent studies have emphasized their benefits in Alzheimer’s disease, limited information is available on the possible mechanism by which it renders anti-Alzheimer activity. Therefore, the present study seeks to employ molecular docking studies to investigate the binding interactions between active ginger components and various anti-Alzheimer drug targets. Lamarckian genetic algorithm methodology was employed for docking of 12 ligands with 13 different target proteins using AutoDock 4.2 program. Docking protocol was validated by re-docking of all native co-crystallized ligands into their original binding cavities exhibiting a strong correlation coefficient value (r2=0.931 between experimentally reported and docking predicted activities. This value suggests that the approach could be a promising computational tool to aid optimization of lead compounds obtained from ginger. Analysis of binding energy, predicted inhibition constant, and hydrophobic/hydrophilic interactions of ligands with target receptors revealed acetylcholinesterase as most promising, while c-Jun N-terminal kinase was recognized as the least favorable anti-Alzheimer’s drug target. Common structural requirements include hydrogen bond donor/acceptor area, hydrophobic domain, carbon spacer, and distal hydrophobic domain flanked by hydrogen bond donor/acceptor moieties. In addition, drug-likeness score and molecular properties responsible for a good pharmacokinetic profile were calculated

  2. Metastable magnetic domain walls in cylindrical nanowires

    Energy Technology Data Exchange (ETDEWEB)

    Ferguson, C.A.; MacLaren, D.A.; McVitie, S., E-mail: Stephen.McVitie@glasgow.ac.uk

    2015-05-01

    The stability of the asymmetric domain wall (ATDW) in soft magnetic cylindrical nanowires and nanotubes is investigated using micromagnetic simulations. Our calculated phase diagram shows that for cylindrical permalloy nanowires, the transverse domain wall (TDW) is the ground state for radii below 20 nm whilst the Bloch point wall (BPW) is favoured in thicker wires. The ATDW stabilises only as a metastable state but with energy close to that of the BPW. Characterisation of the DW spin structures reveals that the ATDW has a vortex-like surface spin state, in contrast to the divergent surface spins of the TDW. This results in lowering of surface charge above the critical radius. For both cylindrical nanotubes and nanowires we find that ATDWs only appear to exist as metastable static states and are particularly suppressed in nanotubes due to an increase in magnetostatic energy. - Highlights: • We simulate the micromagnetic structures of domain walls in cylindrical nanowires. • A phase diagram identifies ground and metastable states. • Asymmetric transverse walls are metastable in nanowires but suppressed in tubes. • Unrolling surface magnetisation aids visualisation of asymmetry and chirality. • We predict experimental discrimination based on magnetic charge distribution.

  3. Cylindrical vortex wake model: right cylinder

    DEFF Research Database (Denmark)

    Branlard, Emmanuel; Gaunaa, Mac

    2015-01-01

    to recall results from 1D momentum theory. It is shown that a superposition of concentric cylindrical systems predicts the independence of annuli, which is assumed in blade element theory and stream-tube analyses. A simple example of application for the estimation of the velocity deficit upstream of a wind...

  4. Magnetic guns with cylindrical permanent magnets

    DEFF Research Database (Denmark)

    Vokoun, David; Beleggia, Marco; Heller, Luděk

    2012-01-01

    The motion of a cylindrical permanent magnet (projectile) inside a tubular permanent magnet, with both magnets magnetized axially, illustrates nicely the physical principles behind the operation of magnetic guns. The force acting upon the projectile is expressed semi-analytically as derivative...

  5. New photoelectric method for inside cylindricity measurement

    Science.gov (United States)

    Yu, Houyun; Zhao, Zhuanping; Zhao, Ye; Xu, Meijian

    2007-12-01

    Cylindricity is an important parameter in the evaluation for a cylindraceous workpiece. It has a direct effect on the precision of assembly and rotation. However it is difficult to carry out inside cylindricity measurement for a large workpiece (length: 2~3m, diameter >200mm), in which the spindle's straightness and measuring table's motion error deserve consideration. In this paper, a new error separation method is presented based on the application of precise photoelectric inspecting technique. And the two errors will be directly measured according to the deviation of facula. During the measurement, the workpiece is installed erectly on the base to minimize its distortion. Laser collimation initializes the measuring needle and gives real-time state of the measuring table. Two kinds of coordinates are used for error compensation, i.e. absolute and imaging coordinates. In the end, the least squares cylinder is used to calculate the cylindricity after all point data of each section are modified. Overall structure design and detailed measuring steps are also listed. Thus, the models of error compensation and cylindricity evaluation are obtained. Simulation results prove them correct with a satisfying precision.

  6. Deformation of cylindrical shells under thermal shock

    Energy Technology Data Exchange (ETDEWEB)

    Aptukov, V.N. (Institut Mekhaniki Sploshnykh Sred, Perm (USSR))

    1990-06-01

    The deformation and fracture behavior of cylindrical shells under conditions of a nonsymmetric thermal shock is investigated numerically using a two-dimensional formulation. In particular, attention is given to the effect of the shell thickness on the deformation and fracture characteristics. Some computational difficulties associated with the solution of problems of this type are examined. 16 refs.

  7. The double explosive layer cylindrical compaction method

    NARCIS (Netherlands)

    Stuivinga, M.E.C.; Verbeek, H.J.; Carton, E.P.

    1999-01-01

    The standard cylindrical configuration for shock compaction is useful for the compaction of composite materials which have some plastic behavior. It can also be used to densify hard ceramics up to about 85% of the theoretical density (TMD), when low detonation velocity explosives (2-4 km s-1) are us

  8. A large acceptance cylindrical drift chamber detector

    Energy Technology Data Exchange (ETDEWEB)

    Ambrose, D.A. [Texas Univ., Austin, TX (United States); Bachman, M.G. [Texas Univ., Austin, TX (United States); Coffey, W.P. [Texas Univ., Austin, TX (United States); Glass, G. [Texas Univ., Austin, TX (United States); McNaughton, K.H. [Texas Univ., Austin, TX (United States); Riley, P.J. [Texas Univ., Austin, TX (United States); Adams, D.L. [Rice University, Houston, TX 77251 (United States); Gaussiran, T.L. [Rice University, Houston, TX 77251 (United States); Hungerford, E.V. [University of Houston, Houston, TX 77204 (United States); Lan, K.A. [University of Houston, Houston, TX 77204 (United States); Johnston, K. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); McNaughton, M.W. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Penttila, S.I. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Supek, I. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

    1995-10-01

    This paper describes a large acceptance cylindrical drift chamber detector designed and built for the study of the np{yields}pp{pi}{sup -} reaction at neutron beam energies in the range 500-800 MeV. Details of construction, electronics, testing, and detection efficiencies and resolutions are presented. (orig.).

  9. Shear stresses around circular cylindrical openings

    NARCIS (Netherlands)

    Hoogenboom, P.C.J.; Van Weelden, C.; Blom, C.M.B.

    2010-01-01

    In this paper stress concentrations are studied around circular cylindrical openings or voids in a linear elastic continuum. The loading is such that a uniform shear stress occurs in the continuum, which is disturbed by the opening. The shear stress is in the direction of the centre axis of the open

  10. Antibubbles and fine cylindrical sheets of air

    KAUST Repository

    Beilharz, D.

    2015-08-14

    Drops impacting at low velocities onto a pool surface can stretch out thin hemispherical sheets of air between the drop and the pool. These air sheets can remain intact until they reach submicron thicknesses, at which point they rupture to form a myriad of microbubbles. By impacting a higher-viscosity drop onto a lower-viscosity pool, we have explored new geometries of such air films. In this way we are able to maintain stable air layers which can wrap around the entire drop to form repeatable antibubbles, i.e. spherical air layers bounded by inner and outer liquid masses. Furthermore, for the most viscous drops they enter the pool trailing a viscous thread reaching all the way to the pinch-off nozzle. The air sheet can also wrap around this thread and remain stable over an extended period of time to form a cylindrical air sheet. We study the parameter regime where these structures appear and their subsequent breakup. The stability of these thin cylindrical air sheets is inconsistent with inviscid stability theory, suggesting stabilization by lubrication forces within the submicron air layer. We use interferometry to measure the air-layer thickness versus depth along the cylindrical air sheet and around the drop. The air film is thickest above the equator of the drop, but thinner below the drop and up along the air cylinder. Based on microbubble volumes, the thickness of the cylindrical air layer becomes less than 100 nm before it ruptures.

  11. Simplified dispersion curves for circular cylindrical shells using shallow shell theory

    Science.gov (United States)

    Sarkar, Abhijit; Sonti, Venkata R.

    2009-04-01

    An alternative derivation of the dispersion relation for the transverse vibration of a circular cylindrical shell is presented. The use of the shallow shell theory model leads to a simpler derivation of the same result. Further, the applicability of the dispersion relation is extended to the axisymmetric mode and the high frequency beam mode.

  12. Noncontinuous Froude Number Scaling for the Closure Depth of a Cylindrical Cavity

    NARCIS (Netherlands)

    Gekle, Stephan; Gekle, S.; van der Bos, J.A.; van der Bos, Arjan; Bergmann, R.P.H.M.; van der Meer, Roger M.; Lohse, Detlef

    2008-01-01

    A long, smooth cylinder is dragged through a water surface to create a cavity with an initially cylindrical shape. This surface void then collapses due to the hydrostatic pressure, leading to a rapid and axisymmetric pinch-off in a single point. Surprisingly, the depth at which this pinch-off takes

  13. Sedimentation of Rigid Cylindrical Particles with Mechanical Contacts

    Institute of Scientific and Technical Information of China (English)

    LIN Jian-Zhong; WANG Ye-Long; James A. Olsen

    2005-01-01

    @@ A collision model of two cylindrical particles is put forward. Based on the model the sedimentation of rigid cylindrical particles with mechanical contacts is simulated numerically by using the lattice Boltzmann method.

  14. Influence of Ring Stiffeners on a Steel Cylindrical Shell

    Directory of Open Access Journals (Sweden)

    D. Lemák

    2005-01-01

    Full Text Available Shell structures are usually formed from concrete, steel and nowadays also from many others materials. Steel is typically used in the structures of chimneys, reservoirs, silos, pipelines, etc. Unlike concrete shells, steel shells are regularly stiffened with the help of longitudinal and/or ring stiffeners.The authors of this paper investigated steel cylindrical shells and their stiffening with the use of ring stiffeners. The more complete the stiffening, the more closely the shell will act to beam theory, and the calculations will be much easier. However, this would make realization of the structure more expensive and more laborious. The target of the study is to find the limits of ring stiffeners for cylindrical shells. Adequate stiffeners will eliminate semi-bending action of the shells in such way that the shell structures can be analyzed with the use of numerical models of the struts (e.g., by beam theory without significant divergences from reality. Recommendations are made for the design of ring stiffeners, especially for the distances between stiffeners and for their bending stiffness. 

  15. Numerical Simulation of Large Diameter Cylindrical Structure Slamming

    Institute of Scientific and Technical Information of China (English)

    XU Jing; WANG De-yu

    2008-01-01

    The water entry of large diameter cylindrical structure is studied by applying numerical simulation method. The processes of different diameter cylindrical structures impacting water with various constant velocities are calculated numerically. Thereafter, analyzed are the distribution of slamming pressure on structure during slamming course and the influence of slamming velocity and cylindrical diameter on slamming process. Furthermore, presented herein is an equation being used to forecast the peak slamming force on a large diameter cylindrical structure.

  16. Stability of cylindrical thin shell wormhole during evolution of universe from inflation to late time acceleration

    Energy Technology Data Exchange (ETDEWEB)

    Setare, M.R. [Department of Science, Campus of Bijar, University of Kurdistan,Bijar (Iran, Islamic Republic of); Sepehri, A. [Faculty of Physics, Shahid Bahonar University,P.O. Box 76175, Kerman (Iran, Islamic Republic of)

    2015-03-16

    In this paper, we consider the stability of cylindrical wormholes during evolution of universe from inflation to late time acceleration epochs. We show that there are two types of cylindrical wormholes. The first type is produced at the corresponding point where k black F-strings are transited to BIon configuration. This wormhole transfers energy from extra dimensions into our universe, causes inflation, loses it’s energy and vanishes. The second type of cylindrical wormhole is created by a tachyonic potential and causes a new phase of acceleration. We show that wormhole parameters grow faster than the scale factor in this era, overtake it at ripping time and lead to the destruction of universe at big rip singularity.

  17. Magnetization curves for general cylindrical samples in a transverse field

    Indian Academy of Sciences (India)

    K V Bhagwat; Debjani Karmakar

    2001-10-01

    Using the recent results for the surface current density on cylindrical surfaces of arbitrary cross-section producing uniform interior magnetic field we propose a method for obtaining solutions of Bean’s critical state model for general cylindrical samples. The method uses the technique of conformal mapping to express the sample surface and the flux-fronts in terms of a set of coefficients that depend on a parameter. The flux-fronts are to be determined by solving a system of nonlinear ordinary differential equations for the coefficients. Retaining only a certain finite number of leading coefficients we get an approximate solution. The procedure is illustrated by considering two cylindrical samples – one with an elliptical cross-section and the other with a non-elliptical cross-section. The virgin curve and small and large magnetization hysteresis loops for the two samples are obtained.

  18. Plastic Limit Load Analysis of Cylindrical Pressure Vessels with Different Nozzle Inclination

    Science.gov (United States)

    Prakash, Anupam; Raval, Harit Kishorchandra; Gandhi, Anish; Pawar, Dipak Bapu

    2016-04-01

    Sudden change in geometry of pressure vessel due to nozzle cutout, leads to local stress concentration and deformation, decreasing its strength. Elastic plastic analysis of cylindrical pressure vessels with different inclination angles of nozzle is important to estimate plastic limit load. In the present study, cylindrical pressure vessels with combined inclination of nozzles (i.e. in longitudinal and radial plane) are considered for elastic plastic limit load analysis. Three dimensional static nonlinear finite element analyses of cylindrical pressure vessels with nozzle are performed for incremental pressure loading. The von Mises stress distribution on pressure vessel shows higher stress zones at shell-nozzle junction. Approximate plastic limit load is obtained by twice elastic slope method. Variation in limit pressure with different combined inclination angle of nozzle is analyzed and found to be distinct in nature. Reported results can be helpful in optimizing pressure vessel design.

  19. Analysis of bearings behaviour with cylindrical rollers with variable center of gravity

    Directory of Open Access Journals (Sweden)

    Barabas Sorin

    2017-01-01

    Full Text Available This paper consists in analysis of the contact stress and deformations appeared to the cylindrical rollers with variable center of gravity who equips large bearings, with finite elements method. Also it proposed an innovative model of lubrication system mounts in the hollow cylindrical rollers of the large bearings where it is stored the lubricant who is driven to the raceways through holes fitted with closing/opening systems made in the cover, controlled by a command system, monitoring and control, equipped with temperature sensors and wireless command. Elimination of lubricant, in stages, leads to changes in position of center of gravity of roller, thus to change its behavior in functioning. Comparison of deformations occurred in cylindrical rollers, solid, with hollowness, and with variable center of gravity, allow favorable conclusions, on the implementation of the proposed lubrication system.

  20. Feasibility studies for quarkonium production at a fixed-target experiment using the LHC proton and lead beams (AFTER@LHC)

    CERN Document Server

    Massacrier, L; Fleuret, F; Hadjidakis, C; Kikola, D; Lansberg, J P; Shao, H -S

    2015-01-01

    Used in the fixed-target mode, the multi-TeV LHC proton and lead beams allow for studies of heavy-flavour hadroproduction with unprecedented precision at backward rapidities - far negative Feyman-x - using conventional detection techniques. At the nominal LHC energies, quarkonia can be studies in detail in p+p, p+d and p+A collisions at sqrt(s_NN) ~ 115 GeV as well as in Pb+p and Pb+A collisions at sqrt(s_NN) ~ 72 GeV with luminosities roughly equivalent to that of the collider mode, i.e. up to 20 fb-1 yr-1 in p+p and p+d collisions, up to 0.6 fb-1 yr-1 in p+A collisions and up to 10 nb-1 yr-1 in Pb+A collisions. In this paper, we assess the feasibility of such studies by performing fast simulations using the performance of a LHCb-like detector.

  1. Feasibility Studies for Quarkonium Production at a Fixed-Target Experiment Using the LHC Proton and Lead Beams (AFTER@LHC

    Directory of Open Access Journals (Sweden)

    L. Massacrier

    2015-01-01

    Full Text Available Being used in the fixed-target mode, the multi-TeV LHC proton and lead beams allow for studies of heavy-flavour hadroproduction with unprecedented precision at backward rapidities, far negative Feynman-x, using conventional detection techniques. At the nominal LHC energies, quarkonia can be studied in detail in p+p, p+d, and p+A collisions at sNN≃115 GeV and in Pb + p and Pb + A collisions at sNN≃72 GeV with luminosities roughly equivalent to that of the collider mode that is up to 20 fb−1 yr−1 in p+p and p+d collisions, up to 0.6 fb−1 yr−1 in p+A collisions, and up to 10 nb−1 yr−1 in Pb + A collisions. In this paper, we assess the feasibility of such studies by performing fast simulations using the performance of a LHCb-like detector.

  2. Targeting the unique methylation pattern of androgen receptor (AR) promoter in prostate stem/progenitor cells with 5-aza-2'-deoxycytidine (5-AZA) leads to suppressed prostate tumorigenesis.

    Science.gov (United States)

    Tian, Jing; Lee, Soo Ok; Liang, Liang; Luo, Jie; Huang, Chiung-Kuei; Li, Lei; Niu, Yuanjie; Chang, Chawnshang

    2012-11-16

    Androgen receptor (AR) expression surveys found that normal prostate/prostate cancer (PCa) stem/progenitor cells, but not embryonic or mesenchymal stem cells, expressed little AR with high methylation in the AR promoter. Mechanism dissection revealed that the differential methylation pattern in the AR promoter could be due to differential expression of methyltransferases and binding of methylation binding protein to the AR promoter region. The low expression of AR in normal prostate/PCa stem/progenitor cells was reversed after adding 5-aza-2'-deoxycytidine, a demethylating agent, which could then lead to decreased stemness and drive cells into a more differentiated status, suggesting that the methylation in the AR promoter of prostate stem/progenitor cells is critical not only in maintaining the stemness but also critical in protection of cells from differentiation. Furthermore, induced AR expression, via alteration of its methylation pattern, led to suppression of the self-renewal/proliferation of prostate stem/progenitor cells and PCa tumorigenesis in both in vitro assays and in vivo orthotopic xenografted mouse studies. Taken together, these data prove the unique methylation pattern of AR promoter in normal prostate/PCa stem/progenitor cells and the influence of AR on their renewal/proliferation and differentiation. Targeting PCa stem/progenitor cells with alteration of methylated AR promoter status might provide a new potential therapeutic approach to battle PCa because the PCa stem/progenitor cells have high tumorigenicity.

  3. Implosion of Cylindrical Cavities via Short Duration Impulsive Loading

    Science.gov (United States)

    Huneault, Justin; Higgins, Andrew

    2014-11-01

    An apparatus has been developed to study the collapse of a cylindrical cavity in gelatin subjected to a symmetric impact-driven impulsive loading. A gas-driven annular projectile is accelerated to approximately 50 m/s, at which point it impacts a gelatin casting confined by curved steel surfaces that allow a transition from an annular geometry to a cylindrically imploding motion. The implosion is visualized by a high-speed camera through a window which forms the top confining wall of the implosion cavity. The initial size of the cavity is such that the gelatin wall is two to five times thicker than the impacting projectile. Thus, during impact the compression wave which travels towards the cavity is closely followed by a rarefaction resulting from the free surface reflection of the compression wave in the projectile. As the compression wave in the gelatin reaches the inner surface, it will also reflect as a rarefaction wave. The interaction between the rarefaction waves from the gelatin and projectile free surfaces leads to large tensile stresses resulting in the spallation of a relatively thin shell. The study focuses on the effect of impact parameters on the thickness and uniformity of the imploding shell formed by the cavitation in the imploding gelatin cylinder.

  4. On the physics of propagating Bessel modes in cylindrical waveguides

    Science.gov (United States)

    Gómez-Correa, J. E.; Balderas-Mata, S. E.; Coello, V.; Puente, N. P.; Rogel-Salazar, J.; Chávez-Cerda, S.

    2017-05-01

    In this paper, we demonstrate that by using a mathematical physics approach—focusing attention on the physics and using mathematics as a tool—it is possible to visualize the formation of the transverse modes inside a cylindrical waveguide. The opposite (physical mathematics) approach looks at the mathematical problem and then tries to impose a physical interpretation. For cylindrical waveguides, the physical mathematics route leads to the Bessel differential equation, and it is argued that in the core of the waveguide there are only Bessel functions of the first kind in the description of the transverse modes. The Neumann functions are deemed non-physical due to their singularity at the origin and are eliminated from the final description of the solution. In this paper, by combining geometric optics and wave optics concepts, we show that the inclusion of the Neumann function is physically necessary to describe fully and properly the formation of the propagating transverse modes. With this approach, we also show that the field outside a dielectric waveguide arises in a natural way.

  5. Variable-focus cylindrical liquid lens array

    Science.gov (United States)

    Zhao, Wu-xiang; Liang, Dong; Zhang, Jie; Liu, Chao; Zang, Shang-fei; Wang, Qiong-hua

    2013-06-01

    A variable-focus cylindrical liquid lens array based on two transparent liquids of different refractive index is demonstrated. An elastic membrane divides a transparent reservoir into two chambers. The two chambers are filled with liquid 1 and liquid 2, respectively, which are of different refractive index. The micro-clapboards help liquid 1, liquid 2 and the elastic membrane form a cylindrical lens array. Driving these two liquids to flow can change the shape of the elastic membrane as well as the focal length. In this design, the gravity effect of liquid can be overcome. A demo lens array of positive optical power is developed and tested. Moreover, a potential application of the proposed lens array for autostereoscopic 3D displays is emphasized.

  6. Ion distributions in plane and cylindrical chambers.

    Science.gov (United States)

    Rosen, R; George, E P

    1975-11-01

    The ion chamber equations of Thomson include both ion recombination and space-charge terms. Neglecting the space-charge term, an exact solution is obtained for the ion densities across a plane ionization chamber. The method is extended to the cylindrical chamber, and examples are given of the expected ion distributions in both geometries. Current-voltage relationships are derived for both chambers and compared with those of other workers. If the space-charge term is retained, the ion chamber equations for both geometries are not soluble in closed form. The cylindrical chamber is considered and a computer solution is obtained for the ion distributions and current. Comparison with the nonspace-charge solution shows that while there is only a small difference in the current-voltage relationship, a significant difference can occur in the ion concentrations.

  7. Buckling optimisation of sandwich cylindrical panels

    Science.gov (United States)

    Abouhamzeh, M.; Sadighi, M.

    2016-06-01

    In this paper, the buckling load optimisation is performed on sandwich cylindrical panels. A finite element program is developed in MATLAB to solve the governing differential equations of the global buckling of the structure. In order to find the optimal solution, the genetic algorithm Toolbox in MATLAB is implemented. Verifications are made for both the buckling finite element code and also the results from the genetic algorithm by comparisons to the results available in literature. Sandwich cylindrical panels are optimised for the buckling strength with isotropic or orthotropic cores with different boundary conditions. Results are presented in terms of stacking sequence of fibers in the face sheets and core to face sheet thickness ratio.

  8. Crack problem in a long cylindrical superconductor

    Science.gov (United States)

    Yong, Hua-Dong; Zhou, You-He; Zeng, Jun

    2008-12-01

    In this work, the general problem of a center crack in a long cylindrical superconductor is studied. The dependence of the stress intensity factor on the parameters, including the crack length and the applied field, is investigated. We presented a simple model in which the effect of the crack on the critical current is taken into account. It is assumed that the crack forms a perfect barrier to the flow of current. The Bean model and the Kim model are considered for the critical state. Based on the complex potential and boundary collocation methods, the stress intensity factor under the magnetic field is obtained for a long cylindrical superconductor containing a central crack. The results show that the crack length and the applied field have significant effects on the fracture behavior of the superconductor.

  9. Surface superconductivity in thin cylindrical Bi nanowire.

    Science.gov (United States)

    Tian, Mingliang; Wang, Jian; Ning, Wei; Mallouk, Thomas E; Chan, Moses H W

    2015-03-11

    The physical origin and the nature of superconductivity in nanostructured Bi remains puzzling. Here, we report transport measurements of individual cylindrical single-crystal Bi nanowires, 20 and 32 nm in diameter. In contrast to nonsuperconducting Bi nanoribbons with two flat surfaces, cylindrical Bi nanowires show superconductivity below 1.3 K. However, their superconducting critical magnetic fields decrease with their diameter, which is the opposite of the expected behavior for thin superconducting wires. Quasiperiodic oscillations of magnetoresistance were observed in perpendicular fields but were not seen in the parallel orientation. These results can be understood by a model of surface superconductivity with an enhanced surface-to-bulk volume in small diameter wires, where the superconductivity originates from the strained surface states of the nanowires due to the surface curvature-induced stress.

  10. Expansion-free Cylindrically Symmetric Models

    CERN Document Server

    Sharif, M

    2013-01-01

    This paper investigates cylindrically symmetric distribution of an-isotropic fluid under the expansion-free condition, which requires the existence of vacuum cavity within the fluid distribution. We have discussed two family of solutions which further provide two exact models in each family. Some of these solutions satisfy Darmois junction condition while some show the presence of thin shell on both boundary surfaces. We also formulate a relation between the Weyl tensor and energy density.

  11. Rarefied gas flow in a cylindrical annulus

    Science.gov (United States)

    Lo, S. S.; Loyalka, S. K.; Storvick, T. S.

    1983-09-01

    The Hansen-Morse model of the linearized Wang Chang-Uhlenbeck equation is used to study the thermal transpiration and mechanocaloric effects for rarefied polyatomic gases in a cylindrical annulus, where boundary conditions are characterized by diffuse reflection. Phenomenological coefficients at all degrees of rarefaction are reported for physical parameters that represent helium, hydrogen, carbon dioxide, and air. Comparisons with isothermal flow data are given.

  12. Machining Thin-Walled Cylindrical Parts

    Science.gov (United States)

    Cimbak, Joe; Spagnolo, Jim; Kraus, Dan

    1988-01-01

    Cylindrical walls only few thousandths of inch thick machined accurately and without tears or punctures with aid of beryllium copper mandrel. Chilled so it contracts, then inserted in cylinder. As comes to room temperature, mandrel expands and fits snugly inside cylinder. Will not allow part to slide and provides solid backup to prevent deflection when part machined by grinding wheel. When machining finished, cylinder-and-mandrel assembly inserted in dry ice, mandrel contracts and removed from part.

  13. Simulation Analysis of Cylindrical Panoramic Image Mosaic

    Directory of Open Access Journals (Sweden)

    ZHU Ningning

    2017-04-01

    Full Text Available With the rise of virtual reality (VR technology, panoramic images are used more widely, which obtained by multi-camera stitching and take advantage of homography matrix and image transformation, however, this method will destroy the collinear condition, make it's difficult to 3D reconstruction and other work. This paper proposes a new method for cylindrical panoramic image mosaic, which set the number of mosaic camera, imaging focal length, imaging position and imaging attitude, simulate the mapping process of multi-camera and construct cylindrical imaging equation from 3D points to 2D image based on photogrammetric collinearity equations. This cylindrical imaging equation can not only be used for panoramic stitching, but also be used for precision analysis, test results show: ①this method can be used for panoramic stitching under the condition of multi-camera and incline imaging; ②the accuracy of panoramic stitching is affected by 3 kinds of parameter errors including focus, displacement and rotation angle, in which focus error can be corrected by image resampling, displacement error is closely related to object distance and rotation angle error is affected mainly by the number of cameras.

  14. Characteristics of Left-Right Spiral Hollow Cylindrical Roller

    Institute of Scientific and Technical Information of China (English)

    Liming Lu; Qiping Chen; Yujiang Qin

    2015-01-01

    Based on new rolling⁃sliding compound bearings, the wear between the one⁃way spiral hollow cylindrical roller and the ribs of the inner and outer ring of rolling⁃sliding compound bearings is reduced by innovational structural design. A new left⁃right spiral hollow cylindrical roller is proposed to replace the one⁃way spiral hollow cylindrical roller. The finite element analysis models of ordinary cylindrical rollers, one⁃way spiral hollow cylindrical rollers and left⁃right spiral hollow cylindrical rollers are respectively established by ABAQUS. The axial displacement of their center mass and the stress distribution of left⁃right spiral hollow cylindrical rollers are compared and analyzed. Theoretical study results show that this new left⁃right spiral hollow cylindrical roller not only inherits the advantages of one⁃way spiral hollow cylindrical rollers, but also avoids the axial offset and the serious wear of the one⁃way spiral hollow cylindrical roller. And the theory research conclusion is verified by the experiment. The left⁃right spiral hollow cylindrical roller has the advantages to overcome boundary stress concentration like logarithmic convex roller. The rolling⁃sliding compound bearings equipped with the new rollers can be better to adapt to the impact of vibration load.

  15. Transmembrane TNF-alpha reverse signaling leading to TGF-beta production is selectively activated by TNF targeting molecules: Therapeutic implications.

    Science.gov (United States)

    Szondy, Zsuzsa; Pallai, Anna

    2017-01-01

    Tumor necrosis factor (TNF)-α is a potent pro-inflammatory cytokine exerting pleiotropic effects on various cell types. It is synthesized in a precursor form called transmembrane TNF-α (mTNF-α) which, after being processed by metalloproteinases, is released in a soluble form to mediate its biological activities through Type 1 and 2 TNF receptors in TNF receptor expressing cells. In addition to acting in soluble form, TNF-α also acts in the transmembrane form both as a ligand by activating TNF receptors, as well as a receptor that transmits outside-to-inside (reverse) signals back into mTNF-α bearing cells. Since the discovery that TNF-α plays a determining role in the pathogenesis of several chronic inflammatory diseases, anti-TNF agents are increasingly being used in the treatment of a rapidly expanding number of rheumatic and systemic autoimmune diseases, such as rheumatoid arthritis, Crohn's disease, psoriasis, psoriatic arthritis, ankyloting spondylitis, Wegener granulomatosis and sarcoidosis. There are 5 TNF antagonists currently available: etanercept, a soluble TNF receptor construct; infliximab, a chimeric monoclonal antibody; adalimumab and golimumab, fully human antibodies; and certolizumab pegol, an Fab' fragment of a humanized anti-TNF-α antibody. Though each compound can efficiently neutralize TNF-α, increasing evidence suggests that they show different efficacy in the treatment of these diseases. These observations indicate that in addition to neutralizing TNF-α, other biological effects induced by TNF-α targeting molecules dictate the success of the therapy. Recently, we found that mTNF-α reverse signaling leads to transforming growth factor (TGF)-β production in macrophages and anti-TNF agents selectively trigger this pathway. In this review we will focus on the potential contribution of the activation of the mTNF-α signaling pathway to the success of the anti-TNF therapy.

  16. Note: Continuous synthesis of uniform vertical graphene on cylindrical surfaces.

    Science.gov (United States)

    Bo, Zheng; Cui, Shumao; Yu, Kehan; Lu, Ganhua; Mao, Shun; Chen, Junhong

    2011-08-01

    This note describes a new reactor design for continuous synthesis of vertically oriented graphene (VG) sheets on cylindrical wire substrates using an atmospheric plasma-enhanced chemical vapor deposition (PECVD) system. Through combining a U-shaped reactor design with "dynamic mode" synthesis featuring simultaneous rotational and axial movements of the metallic wire substrate, the new setup can enable continuous synthesis of VG sheets on the wire surface with remarkable uniformity in both circumferential and axial directions. In contrast, synthesis of VG at "static mode" with a fixed substrate can only lead to non-uniform growth of VG sheets on the wire surface. Potential applications of the resulting uniform-VG-coated metallic wire could include field emitters, field-ionization-based neutral atom detectors, and indoor corona discharges.

  17. From Cylindrical to Stretching Ridges and Wrinkles in Twisted Ribbons

    Science.gov (United States)

    Pham Dinh, Huy; Démery, Vincent; Davidovitch, Benny; Brau, Fabian; Damman, Pascal

    2016-09-01

    Twisted ribbons under tension exhibit a remarkably rich morphology, from smooth and wrinkled helicoids, to cylindrical or faceted patterns. This complexity emanates from the instability of the natural, helicoidal symmetry of the system, which generates both longitudinal and transverse stresses, thereby leading to buckling of the ribbon. Here, we focus on the tessellation patterns made of triangular facets. Our experimental observations are described within an "asymptotic isometry" approach that brings together geometry and elasticity. The geometry consists of parametrized families of surfaces, isometric to the undeformed ribbon in the singular limit of vanishing thickness and tensile load. The energy, whose minimization selects the favored structure among those families, is governed by the tensile work and bending cost of the pattern. This framework describes the coexistence lines in a morphological phase diagram, and determines the domain of existence of faceted structures.

  18. Circumferential buckling instability of a growing cylindrical tube

    KAUST Repository

    Moulton, D.E.

    2011-03-01

    A cylindrical elastic tube under uniform radial external pressure will buckle circumferentially to a non-circular cross-section at a critical pressure. The buckling represents an instability of the inner or outer edge of the tube. This is a common phenomenon in biological tissues, where it is referred to as mucosal folding. Here, we investigate this buckling instability in a growing elastic tube. A change in thickness due to growth can have a dramatic impact on circumferential buckling, both in the critical pressure and the buckling pattern. We consider both single- and bi-layer tubes and multiple boundary conditions. We highlight the competition between geometric effects, i.e. the change in tube dimensions, and mechanical effects, i.e. the effect of residual stress, due to differential growth. This competition can lead to non-intuitive results, such as a tube growing to be thinner and yet buckle at a higher pressure. © 2011 Elsevier Ltd. All rights reserved.

  19. The Einstein field equations for cylindrically symmetric elastic configurations

    Energy Technology Data Exchange (ETDEWEB)

    Brito, I; Vaz, E G L R [Departamento de Matematica e Aplicacoes, Universidade do Minho, 4800-058 Guimaraes (Portugal); Carot, J, E-mail: ireneb@math.uminho.pt, E-mail: jcarot@uib.cat, E-mail: evaz@math.uminho.pt [Departament de Fisica, Universitat de les Illes Balears, Cra Valdemossa pk 7.5, E-07122 Palma (Spain)

    2011-09-22

    In the context of relativistic elasticity it is interesting to study axially symmetric space-times due to their significance in modeling neutron stars and other astrophysical systems of interest. To approach this problem, here, a particular class of these space-times is considered. A cylindrically symmetric elastic space-time configuration is studied, where the material metric is taken to be flat. The components of the energy-momentum tensor for elastic matter are written in terms of the invariants of the strain tensor, here chosen to be the eigenvalues of the pulled-back material metric. The Einstein field equations are presented and a condition confirming the existence of a constitutive function is obtained. This condition leads to special cases, in one of which a new system for the metric functions and an expression for the constitutive function are deduced. The new system depends on a particular function, which builds up the constitutive equation.

  20. Pulsed ion sheath dynamics in a cylindrical bore for inner surface grid-enhanced plasma source ion implantation

    CERN Document Server

    Wang Jiu Li; Fan Song Hua; Yang Wu Bao; Yang Size

    2002-01-01

    Based on authors' recently proposed grid-enhanced plasma source ion implantation (GEPSII) technique for inner surface modification of materials with cylindrical geometry, the authors present the corresponding theoretical studies of the temporal evolution of the plasma ion sheath between the grid electrode and the target in a cylindrical bore. Typical results such as the ion sheath evolution, time-dependent ion density and time-integrated ion energy distribution at the target are calculated by solving Poisson's equation coupled with fluid equations for collisionless ions and Boltzmann assumption for electrons using finite difference methods. The calculated results can further verify the feasibility and superiority of this new technique

  1. The ignition design space of magnetized target fusion

    Energy Technology Data Exchange (ETDEWEB)

    Lindemuth, Irvin R. [2490 North Grannen Road, Tucson, Arizona 85745 (United States)

    2015-12-15

    The simple magnetized target implosion model of Lindemuth and Kirkpatrick [Nucl. Fusion 23, 263 (1983)] has been extended to survey the potential parameter space in which three types of magnetized targets—cylindrical with axial magnetic field, cylindrical with azimuthal magnetic field, and spherical with azimuthal magnetic field—might achieve ignition and produce large gain at achievable radial convergence ratios. The model has been used to compute the dynamic, time-dependent behavior of many initial parameter sets that have been based upon projected ignition conditions using the quasi-adiabatic and quasi-flux-conserving properties of magnetized target implosions. The time-dependent calculations have shown that energy gains greater than 30 can potentially be achieved for each type of target. By example, it is shown that high gain may be obtained at extremely low convergence ratios, e.g., less than 15, for appropriate initial conditions. It is also shown that reaching the ignition condition, i.e., when fusion deposition rates equal total loss rates, does not necessarily lead to high gain and high fuel burn-up. At the lower densities whereby fusion temperatures can be reached in magnetized targets, the fusion burn rate may be only comparable with the hydrodynamic heating/cooling rates. On the other hand, when the fusion burn rates significantly exceed the hydrodynamic rates, the calculations show a characteristic rapid increase in temperature due to alpha particle deposition with a subsequent increased burn rate and high gain. A major result of this paper is that each type of target operates in a different initial density-energy-velocity range. The results of this paper provide initial target plasma parameters and driver parameters that can be used to guide plasma formation and driver development for magnetized targets. The results indicate that plasmas for spherical, cylindrical with azimuthal field, and cylindrical with axial field targets must have an initial

  2. Radiation of sound from unflanged cylindrical ducts

    Science.gov (United States)

    Hartharan, S. L.; Bayliss, A.

    1983-01-01

    Calculations of sound radiated from unflanged cylindrical ducts are presented. The numerical simulation models the problem of an aero-engine inlet. The time dependent linearized Euler equations are solved from a state of rest until a harmonic solution is attained. A fourth order accurate finite difference scheme is used and solutions are obtained from a fully vectorized Cyber-203 computer program. Cases of both plane waves and spin modes are treated. Spin modes model the sound generated by a turbofan engine. Boundary conditions for both plane waves and spin modes are treated. Solutions obtained are compared with experiments conducted at NASA Langley Research Center.

  3. Free vibrations of circular cylindrical shells

    CERN Document Server

    Armenàkas, Anthony E; Herrmann, George

    1969-01-01

    Free Vibrations of Circular Cylindrical Shells deals with thin-walled structures that undergo dynamic loads application, thereby resulting in some vibrations. Part I discusses the treatment of problems associated with the propagation of plane harmonic waves in a hollow circular cylinder. In such search for solutions, the text employs the framework of the three-dimensional theory of elasticity. The text explains the use of tables of natural frequencies and graphs of representative mode shapes of harmonic elastic waves bounding in an infinitely long isotropic hollow cylinder. The tables are

  4. Kaluza-Klein Magnetized Cylindrical Wormhole

    CERN Document Server

    Hashemi, S Sedigheh

    2015-01-01

    A new exact vacuum solution in five dimensions, which describes a magnetized cylindrical wormhole in $3+1$ dimensions is presented. The magnetic field lines are stretched along the wormhole throat and are concentrated near to it. We study the motion of neutral and charged test particles under the influence of the magnetized wormhole. The effective potential for a neutral test particle around and across the magnetized wormhole has a repulsive character. The total magnetic flux on either side of the wormhole is obtained. We present analytic expressions which show regions in which the null energy condition is violated.

  5. A cylindrical furnace for absorption spectral studies

    Indian Academy of Sciences (India)

    R Venkatasubramanian

    2001-06-01

    A cylindrical furnace with three heating zones, capable of providing a temperature of 1100°C, has been fabricated to enable recording of absorption spectra of high temperature species. The temperature of the furnace can be controlled to ± 1°C of the set temperature. The salient feature of this furnace is that the material being heated can be prevented from depositing on the windows of the absorption cell by maintaining a higher temperature at both the ends of the absorption cell.

  6. Cylindrical metamaterial-based subwavelength antenna

    DEFF Research Database (Denmark)

    Erentok, Aycan; Kim, Oleksiy S.; Arslanagic, Samel

    2009-01-01

    A subwavelength monopole antenna radiating in the presence of a truncated cylindrical shell, which has a capped top face and is made of a negative permittivity metamaterial, is analyzed numerically by a method of moments for the volume-surface integral equation oil the one hand, and a finite...... element method on the other hand. It is shown that a center-fed truncated cylinder, in contrast to an infinite cylinder, provides subwavelength resonances, thus suggesting the possibility, of having a subwavelength antenna system....

  7. Stability analysis of cylindrical Vlasov equilibria

    Energy Technology Data Exchange (ETDEWEB)

    Short, R.W.

    1979-01-01

    A general method of stability analysis is described which may be applied to a large class of such problems, namely those which are described dynamically by the Vlasov equation, and geometrically by cylindrical symmetry. The method is presented for the simple case of the Vlasov-Poisson (electrostatic) equations, and the results are applied to a calculation of the lower-hybrid-drift instability in a plasma with a rigid rotor distribution function. The method is extended to the full Vlasov-Maxwell (electromagnetic) equations. These results are applied to a calculation of the instability of the extraordinary electromagnetic mode in a relativistic E-layer interacting with a background plasma.

  8. OPTIMAL THICKNESS OF A CYLINDRICAL SHELL

    Directory of Open Access Journals (Sweden)

    Paul Ziemann

    2015-01-01

    Full Text Available In this paper an optimization problem for a cylindrical shell is discussed. The aim is to look for an optimal thickness of a shell to minimize the deformation under an applied external force. As a side condition, the volume of the shell has to stay constant during the optimization process. The deflection is calculated using an approach from shell theory. The resulting control-to-state operator is investigated analytically and a corresponding optimal control problem is formulated. Moreover, necessary conditions for an optimal solution are stated and numerical solutions are presented for different examples.

  9. The Cylindrical Component Methodology Evaluation Module for MUVES-S2

    Science.gov (United States)

    2017-04-01

    given in Table 1. Table 1 Sample fraction of Cr criteria Component type Material Dia. (inches) Cr Thin-walled control tubes Aluminum 0.5 0.30 0.75... component . In this test case, the target material and line-of-sight thickness of the box surrounding the tubes was modified so that the projectile’s...ARL-TR-7990 ● APR 2017 US Army Research Laboratory The Cylindrical Component Methodology Evaluation Module for MUVES-S2 by

  10. Vacuolar targeting of r-proteins in sugarcane leads to higher levels of purifiable commercially equivalent recombinant proteins in cane juice.

    Science.gov (United States)

    Palaniswamy, Harunipriya; Syamaladevi, Divya P; Mohan, Chakravarthi; Philip, Anna; Petchiyappan, Anushya; Narayanan, Subramonian

    2016-02-01

    Sugarcane is an ideal candidate for biofarming applications because of its large biomass, rapid growth rate, efficient carbon fixation pathway and a well-developed storage tissue system. Vacuoles occupy a large proportion of the storage parenchyma cells in the sugarcane stem, and the stored products can be harvested as juice by crushing the cane. Hence, for the production of any high-value protein, it could be targeted to the lytic vacuoles so as to extract and purify the protein of interest from the juice. There is no consensus vacuolar-targeting sequence so far to target any heterologous proteins to sugarcane vacuole. Hence, in this study, we identified an N-terminal 78-bp-long putative vacuolar-targeting sequence from the N-terminal domain of unknown function (DUF) in Triticum aestivum 6-SFT (sucrose: fructan 6-fructosyl transferase). In this study, we have generated sugarcane transgenics with gene coding for the green fluorescent protein (GFP) fused with the vacuolar-targeting determinants at the N-terminal driven by a strong constitutive promoter (Port ubi882) and demonstrated the targeting of GFP to the vacuoles. In addition, we have also generated transgenics with His-tagged β-glucuronidase (GUS) and aprotinin targeted to the lytic vacuole, and these two proteins were isolated and purified from the transgenic sugarcane and compared with commercially available protein samples. Our studies have demonstrated that the novel vacuolar-targeting determinant could localize recombinant proteins (r-proteins) to the vacuole in high concentrations and such targeted r-proteins can be purified from the juice with a few simple steps.

  11. Forced Vibration Analysis for a FGPM Cylindrical Shell

    Directory of Open Access Journals (Sweden)

    Hong-Liang Dai

    2013-01-01

    Full Text Available This article presents an analytical study for forced vibration of a cylindrical shell which is composed of a functionally graded piezoelectric material (FGPM. The cylindrical shell is assumed to have two-constituent material distributions through the thickness of the structure, and material properties of the cylindrical shell are assumed to vary according to a power-law distribution in terms of the volume fractions for constituent materials, the exact solution for the forced vibration problem is presented. Numerical results are presented to show the effect of electric excitation, thermal load, mechanical load and volume exponent on the static and force vibration of the FGPM cylindrical shell. The goal of this investigation is to optimize the FGPM cylindrical shell in engineering, also the present solution can be used in the forced vibration analysis of cylindrical smart elements.

  12. Optical inspection system for cylindrical objects

    Science.gov (United States)

    Brenden, Byron B.; Peters, Timothy J.

    1989-01-01

    In the inspection of cylindrical objects, particularly O-rings, the object is translated through a field of view and a linear light trace is projected on its surface. An image of the light trace is projected on a mask, which has a size and shape corresponding to the size and shape which the image would have if the surface of the object were perfect. If there is a defect, light will pass the mask and be sensed by a detector positioned behind the mask. Preferably, two masks and associated detectors are used, one mask being convex to pass light when the light trace falls on a projection from the surface and the other concave, to pass light when the light trace falls on a depression in the surface. The light trace may be either dynamic, formed by a scanned laser beam, or static, formed by such a beam focussed by a cylindrical lens. Means are provided to automatically keep the illuminating receiving systems properly aligned.

  13. Vibration analysis of bimodulus laminated cylindrical panels

    Science.gov (United States)

    Khan, K.; Patel, B. P.; Nath, Y.

    2009-03-01

    This paper deals with the flexural vibration behavior of bimodular laminated composite cylindrical panels with various boundary conditions. The formulation is based on first order shear deformation theory and Bert's constitutive model. The governing equations are derived using finite element method and Lagrange's equation of motion. An iterative eigenvalue approach is employed to obtain the positive and negative half cycle free vibration frequencies and corresponding mode shapes. A detailed parametric study is carried out to study the influences of thickness ratio, aspect ratio, lamination scheme, edge conditions and bimodularity ratio on the free vibration characteristics of bimodulus angle- and cross-ply composite laminated cylindrical panels. It is interesting to observe that there is a significant difference between the frequencies of positive and negative half cycles depending on the panel parameters. Through the thickness distribution of modal stresses for positive half cycle is significantly different from that for negative half cycle unlike unimodular case wherein the stresses at a particular location in negative half cycle would be of same magnitude but of opposite sign of those corresponding to positive half cycle. Finally, the effect of bimodularity on the steady state response versus forcing frequency relation is studied for a typical case.

  14. Data fusion for cylindrical form measurements

    Science.gov (United States)

    Liu, Pei; Jusko, Otto; Tutsch, Rainer

    2015-12-01

    For high-precision form measurements of cylindrical workpieces form profiles such as roundness and straightness profiles are independently acquired via a bird-cage strategy. The 3D point cloud reconstructed by fusing these intersected profiles is meaningful in dimension and form assessment for cylinder, since enhanced accuracy can be achieved by fusion results. Moreover, it plays an important role as the input to other calculations. However, these data cannot be accurately aligned in form reconstruction, due to random absolute offsets in profiles and a lack of absolute positions. Therefore, we propose an approach to data fusion of these profiles to reconstruct cylindrical form. The uncertainties of the fused profile are evaluated, taking an individual contribution of a single profile and a global contribution of all profiles into account. The associated uncertainties are propagated using the Monte Carlo method. Experimental study results indicate that the data fusion procedure improves the accuracy of available datasets. After fusion, all available data points are capable of being used in the form assessment.

  15. Code Verification of Magnetized Cylindrical Liner Implosions

    Science.gov (United States)

    Hess, Mark; Weis, Matthew; Martin, Matthew; Sefkow, Adam; Nakhleh, Charles; Lau, Y. Y.

    2012-10-01

    We investigate the physics of magnetized cylindrical liner implosions with existing MHD codes to verify code accuracy, as well as to understand parametric behavior on figures-of-merit, e.g. radial liner velocity, for designing experiments. In our problem, we assume that there exists a 1-D metallic cylindrical liner with an initial axial magnetic seed field imposed in the system. The liner radially implodes due to a specified drive current while the effects of liner pressure and magnetic seed field compression oppose the implosion. This problem is of importance for future magnetized liner fusion experiments, e.g. MagLIF [1].[4pt]Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. [4pt] [1] S.A. Slutz et al, Phys. Plasmas 17, 056303 (2010).

  16. Low distortion laser welding of cylindrical components

    Science.gov (United States)

    Kittel, Sonja

    2011-02-01

    Automotive components are for the most part cylindrical and thus the weld seams are of radial shape. Radial weld seams are usually produced by starting at a point on the component's surface rotating the component resulting in an overlap zone at the start/end of the weld. In this research, it is shown that the component's distortion strongly depends on the overlap of weld start and end. A correlation between overlap zone and distortion is verified by an experimental study. In order to reduce distortion generated by the overlap zone a special optics is used which allows shaping the laser beam into a ring shape which is then focused on the cylindrical surface and produces a radial ring weld seam simultaneously by one laser pulse. In doing this, the overlap zone is eliminated and distortion can be reduced. Radial weld seams are applied on precision samples and distortion is measured after welding. The distortion of the precision samples is measured by a tactile measuring method and a comparison of the results of welding with the ring optics to reference welds is done.

  17. Mapping the genome of Plasmodium falciparum on the drug-like chemical space reveals novel anti-malarial targets and potential drug leads

    DEFF Research Database (Denmark)

    Jensen, Kasper; Plichta, Damian Rafal; Panagiotou, Gianni;

    2012-01-01

    The parasite Plasmodium falciparum is the main agent responsible for malaria. In this study, we exploited a recently published chemical library from GlaxoSmithKline (GSK) that had previously been confirmed to inhibit parasite growth of the wild type (3D7) and the multi-drug resistance (D2d) strains......, in order to uncover the weak links in the proteome of the parasite. We predicted 293 proteins of P. falciparum, including the six out of the seven verified targets for P. falciparum malaria treatment, as targets of 4645 GSK active compounds. Furthermore, we prioritized druggable targets, based on a number...... on integration of available chemical-protein and protein-protein interaction data. Our work suggests that a large number of the P. falciparum proteome is potentially druggable and could therefore serve as novel drug targets in the fight against malaria. At the same time, prioritized compounds from the GSK...

  18. Lack of dystrophin leads to the selective loss of superior cervical ganglion neurons projecting to muscular targets in genetically dystrophic mdx mice.

    Science.gov (United States)

    De Stefano, M Egle; Leone, Lucia; Lombardi, Loredana; Paggi, Paola

    2005-12-01

    Autonomic imbalance is a pathological aspect of Duchenne muscular dystrophy. Here, we show that the sympathetic superior cervical ganglion (SCG) of mdx mice, which lack dystrophin (Dp427), has 36% fewer neurons than that of wild-type animals. Cell loss occurs around P10 and affects those neurons innervating muscular targets (heart and iris), which, differently from the submandibular gland (non-muscular target), are precociously damaged by the lack of Dp427. In addition, although we reveal altered axonal defasciculation in the submandibular gland and reduced terminal sprouting in all SCG target organs, poor adrenergic innervation is observed only in the heart and iris. These alterations, detected as early as P5, when neuronal loss has not yet occurred, suggest that in mdx mice the absence of Dp427 directly impairs the axonal growth and terminal sprouting of sympathetic neurons. However, when these intrinsic alterations combine with structural and/or functional damages of muscular targets, neuronal death occurs.

  19. Magnetostatic interactions and forces between cylindrical permanent magnets

    Energy Technology Data Exchange (ETDEWEB)

    Vokoun, David [Institute of Physics ASCR, v.v.i., Prague (Czech Republic)], E-mail: vokoun@fzu.cz; Beleggia, Marco [Institute for Materials Research, University of Leeds, Leeds LS2 9JT (United Kingdom); Heller, Ludek; Sittner, Petr [Institute of Physics ASCR, v.v.i., Prague (Czech Republic)

    2009-11-15

    Permanent magnets of various shapes are often utilized in magnetic actuators, sensors or releasable magnetic fasteners. Knowledge of the magnetic force is required to control devices reliably. Here, we introduce an analytical expression for calculating the attraction force between two cylindrical permanent magnets on the assumption of uniform magnetization. Although the assumption is not fulfilled exactly in cylindrical magnets, we obtain a very good agreement between the calculated and measured forces between two identical cylindrical magnets and within an array of NdFeB cylindrical magnets.

  20. Magnetostatic interactions and forces between cylindrical permanent magnets

    Science.gov (United States)

    Vokoun, David; Beleggia, Marco; Heller, Luděk; Šittner, Petr

    2009-11-01

    Permanent magnets of various shapes are often utilized in magnetic actuators, sensors or releasable magnetic fasteners. Knowledge of the magnetic force is required to control devices reliably. Here, we introduce an analytical expression for calculating the attraction force between two cylindrical permanent magnets on the assumption of uniform magnetization. Although the assumption is not fulfilled exactly in cylindrical magnets, we obtain a very good agreement between the calculated and measured forces between two identical cylindrical magnets and within an array of NdFeB cylindrical magnets.

  1. Cylindrical polymer brushes with dendritic side chains by iterative anionic reactions

    KAUST Repository

    Zhang, Hefeng

    2015-05-01

    We report in this paper an easy method for the synthesis of cylindrical polymer brushes with dendritic side chains through anionic reaction. The synthesis is accomplished by iteratively grafting a living block copolymer, polyisoprene-. b-polystyrenyllithium (PI-. b-PSLi), to the main chain and subsequently to the branches in a divergent way. PI segment is short and serves as a precursor for multifunctional branching unit. The grafting reaction involves two successive steps: i) epoxidation of internal double bonds of PI segments, either in main chain or side chains; ii) ring-opening addition to the resulting epoxy group by the living PI-. b-PSLi. Repeating the two steps affords a series of cylindrical polymer brushes with up to 3rd generation and extremely high molecular weight. The branching multiplicity depends on the average number of oxirane groups per PI segment, usually ca. 8 in the present work. The high branching multiplicity leads to tremendous increase in molecular weights of the cylindrical products with generation growth. Several series of cylindrical polymer brushes with tunable aspect ratios are prepared using backbones and branches with controlled lengths. Shape anisotropy is investigated in dilute solution using light scattering technique. Worm-like single molecular morphology with large persistence length is observed on different substrates by atomic force microscopy.

  2. An analytical model of heat generation for eccentric cylindrical pin in friction stir welding

    Directory of Open Access Journals (Sweden)

    Ahmed Ramadan Shaaban Essa

    2016-07-01

    Full Text Available An analytical model for heat generation for eccentric cylindrical pin in friction stir welding was developed that utilizes a new factor based on the tool pin eccentricity. The proposed analytical expression is a modification of previous analytical models from the literature, which is verified and well matches with the model developed by previous researchers. Results of plunge force and peak temperature were used to validate the current proposed model. The cylindrical tool pin with eccentricities of 0, 0.2, and 0.8 mm were used to weld two types of aluminum alloys; a low deformation resistant AA1050-H12, and a relatively high deformation resistant AA5754-H24 alloy. The FSW was performed at constant tool rotation speed of 600 rpm and different welding speeds of 100, 300, and 500 mm/min. Experimental results implied that less temperature is generated using eccentric cylindrical pin than cylindrical pin without eccentricity under the given set of FSW process conditions. Furthermore, numerical simulation results show that increasing the pin eccentricity leads to decrease in peak temperature.

  3. Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo

    National Research Council Canada - National Science Library

    Yu, Channing; Cantor, Alan B; Yang, Haidi; Browne, Carol; Wells, Richard A; Fujiwara, Yuko; Orkin, Stuart H

    2002-01-01

    .... Here we demonstrate that deletion of a high-affinity GATA-binding site in the GATA-1 promoter, an element presumed to mediate positive autoregulation of GATA-1 expression, leads to selective loss...

  4. Fabrication of Ni stamp with high aspect ratio, two-leveled, cylindrical microstructures using dry etching and electroplating

    DEFF Research Database (Denmark)

    Petersen, Ritika Singh; Keller, Stephan Sylvest; Hansen, Ole;

    2015-01-01

    We describe a process for the fabrication of a Ni stamp that is applied to the microstructuring of polymers by hot embossing. The target devices are microcontainers that have a potential application in oral drug delivery. Each container is a 3D, cylindrical, high aspect ratio microstructure...

  5. Unbalanced Cylindrical Magnetron for Accelerating Cavities Coating

    CERN Document Server

    Rosaz, Guillaume; Calatroni, Sergio; Sublet, Alban; Tobarelli, Mauro

    2016-01-01

    We report in this paper the design and qualification of a cylindrical unbalanced magnetron source. The dedicated magnetic assemblies were simulated using a finite element model. A hall-effect magnetic probe was then used to characterize those assemblies and compared to the theoretical magnet profiles. These show a good agreement between the expected and actual values. the qualification of the different magnetic assemblies was then performed by measuring the ion flux density reaching the surface of the sample to be coated using a commercial retarding field energy analyzer. The strongest unbalanced configuration shows an increase from 0.016A.cm^-2 to 0.074A.cm^-2 of the ion flux density reaching the sample surface compared to the standard balanced configuration for a pressure 5.10^-3 mbar and a plasma source power of 300W.

  6. Free Vibration of Partially Supported Cylindrical Shells

    Directory of Open Access Journals (Sweden)

    S. Mirza

    1995-01-01

    Full Text Available The effects of detached base length on the natural frequencies and modal shapes of cylindrical shell structures were investigated in this work. Some of the important applications for this type of problem can be found in the cracked fan and rotor blades that can be idealized as partially supported shells with varying unsupported lengths. A finite element model based on small deflection linear theory was developed to obtain numerical solutions for this class of problems. The numerical results were generated for shallow shells and some of the degenerate cases are compared with other results available in the literature. The computations presented here involve a wide range of variables: material properties, aspect ratios, support conditions, and radius to base ratio.

  7. Cylindrical wormholes with positive cosmological constant

    CERN Document Server

    Richarte, Mart'\\in G

    2013-01-01

    We construct cylindrical, traversable wormholes with finite radii by taking into account the cut-and-paste procedure for the case of cosmic string manifolds with a positive cosmological constant. Under reasonable assumptions about the equation of state of the matter located at the shell, we find that the wormhole throat undergoes a monotonous evolution provided it moves at a constant velocity. In order to explore the dynamical nonlinear behaviour of the wormhole throat, we consider that the matter at the shell is supported by anisotropic Chaplygin gas, anti-Chaplygin gas, or a mixed of Chaplygin and anti-Chaplygin gases implying that wormholes could suffer an accelerated expansion or contraction but the oscillatory behavior seems to be forbidden.

  8. Cylindrical wormholes with positive cosmological constant

    Science.gov (United States)

    Richarte, Martín G.

    2013-07-01

    We construct cylindrical, traversable wormholes with finite radii by taking into account the cut-and-paste procedure for the case of cosmic string manifolds with a positive cosmological constant. Under reasonable assumptions about the equation of state of the matter located at the shell, we find that the wormhole throat undergoes a monotonous evolution provided it moves at a constant velocity. In order to explore the dynamical nonlinear behavior of the wormhole throat, we consider that the matter of the shell is supported by anisotropic Chaplygin gas, anti-Chaplygin gas, or a mixture of Chaplygin and anti-Chaplygin gases, implying that wormholes could suffer an accelerated expansion or contraction, but that oscillatory behavior seems to be forbidden.

  9. Mathematical model of cylindrical form tolerance

    Institute of Scientific and Technical Information of China (English)

    蔡敏; 杨将新; 吴昭同

    2004-01-01

    Tolerance is essential for integration of CAD and CAM. Unfortunately, the meaning of tolerances in the national standard is expressed in graphical and language forms and is not adaptable for expression, processing and data transferring with computers. How to interpret its semantics is becoming a focus of relevant studies. This work based on the mathematical definition of form tolerance in ANSI Y 14.5.1 M-1994, established the mathematical model of form tolerance for cylindrical feature. First, each tolerance in the national standard was established by vector equation. Then on the foundation of toler-ance's mathematical definition theory, each tolerance zone's mathematical model was established by inequality based on degrees of feature. At last the variance area of each tolerance zone is derived. This model can interpret the semantics of form tolerance exactly and completely.

  10. Mathematical model of cylindrical form tolerance

    Institute of Scientific and Technical Information of China (English)

    蔡敏; 杨将新; 吴昭同

    2004-01-01

    Tolerance is essential for integration of CAD and CAM.Unfortunately,the meaning of tolerances in the national standard is expressed in graphical and language forms and is not adaptable for expression,processing and data transferring with computers.How to interpret its semantics is becoming a focus of relevant studies.This work based on the mathematical definition of form tolerance in ANSI Y 14.5.1 M-1994,established the mathematical model of form tolerance for cylindrical feature.First,each tolerance in the national standard was established by vector equation.Then on the foundation of tolerance's mathematical definition theory,each tolerance zone's mathematical model was established by inequality based on degrees of feature.At last the variance area of each tolerance zone is derived.This model can interpret the semantics of form tolerance exactly and completely.

  11. Study of Cylindrical Honeycomb Solar Collector

    Directory of Open Access Journals (Sweden)

    Atish Mozumder

    2014-01-01

    Full Text Available We present the results of our investigation on cylindrical honeycomb solar collector. The honeycomb has been fabricated with transparent cellulose triacetate polymer sheets. Insulation characteristics of the honeycomb were studied by varying the separation between the honeycomb and the absorber plate. The optimal value of the separation was found to be 3.3 mm for which the heat transfer coefficient is 3.06 W m−2 K−1. This supports result of previous similar experiments. Further we test the honeycomb through a field experiment conducted in Delhi (28.6°N, 77°E and found that when the incident angle of the solar radiation is within 20° then the performance of the system with the honeycomb is better than the one without the honeycomb.

  12. SPSM and its application in cylindrical shells

    Institute of Scientific and Technical Information of China (English)

    NIE Wu; ZHOU Su-lian; PENG Hui

    2008-01-01

    In naval architectures, the structure of prismatic shell is used widely. But there is no suitable method to analyze this kind of structure. Stiffened prismatic shell method (SPSM) presented in this paper, is one of the harmonic semi-analytic methods. Theoretically, strong stiffened structure can be analyzed economically and accurately. SPSM is based on the analytical solution of the governing differential equations for orthotropic cylindrical shells. In these differential equations, the torsional stiffness, bending stiffness and the exact position of each stiffener are taken into account with the Heaviside singular function. An algorithm is introduced, in which the actions of stiffeners on shells are replaced by external loads at each stiffener position. Stiffened shells can be computed as non-stiffened shells. Eventually, the displacement solution of the equations is acquired by the introduction of Green function. The stresses in a corrugated transverse bulkhead without pier base of an oil tanker are computed by using SPSM.

  13. Indentation of Ellipsoidal and Cylindrical Elastic Shells

    KAUST Repository

    Vella, Dominic

    2012-10-01

    Thin shells are found in nature at scales ranging from viruses to hens\\' eggs; the stiffness of such shells is essential for their function. We present the results of numerical simulations and theoretical analyses for the indentation of ellipsoidal and cylindrical elastic shells, considering both pressurized and unpressurized shells. We provide a theoretical foundation for the experimental findings of Lazarus etal. [following paper, Phys. Rev. Lett. 109, 144301 (2012)PRLTAO0031-9007] and for previous work inferring the turgor pressure of bacteria from measurements of their indentation stiffness; we also identify a new regime at large indentation. We show that the indentation stiffness of convex shells is dominated by either the mean or Gaussian curvature of the shell depending on the pressurization and indentation depth. Our results reveal how geometry rules the rigidity of shells. © 2012 American Physical Society.

  14. Space charge emission in cylindrical diode

    Energy Technology Data Exchange (ETDEWEB)

    Torres-Córdoba, Rafael; Martínez-García, Edgar [Universidad Autónoma de Cd. Juárez-IIT, Cd. Juárez, Chihuahua, México (Mexico)

    2014-02-15

    In this paper, a mathematical model to describe cylindrical electron current emissions through a physics approximation method is presented. The proposed mathematical approximation consists of analyzing and solving the nonlinear Poisson's equation, with some determined mathematical restrictions. Our findings tackle the problem when charge-space creates potential barrier that disable the steady-state of the beam propagation. In this problem, the potential barrier effects of electron's speed with zero velocity emitted through the virtual cathode happens. The interaction between particles and the virtual cathode have been to find the inter-atomic potentials as boundary conditions from a quantum mechanics perspective. Furthermore, a non-stationary spatial solution of the electrical potential between anode and cathode is presented. The proposed solution is a 2D differential equation that was linearized from the generalized Poisson equation. A single condition was used solely, throughout the radial boundary conditions of the current density formation.

  15. Ingestion of six cylindrical and four button batteries

    DEFF Research Database (Denmark)

    Nielsen, Simon U; Rasmussen, Morten; Hoegberg, Lotte C G

    2010-01-01

    We report a suicidal ingestion of six cylindrical and four button batteries, in combination with overdosed prescription medicine and smoking of cannabis.......We report a suicidal ingestion of six cylindrical and four button batteries, in combination with overdosed prescription medicine and smoking of cannabis....

  16. Settling of a cylindrical particle in a stagnant fluid

    DEFF Research Database (Denmark)

    Sørensen, Henrik; Rosendahl, Lasse; Yin, Chungen;

    2007-01-01

    The objective of this work is to collect data and develop models for cylindrical particles which could be used in numerical multiphase flow modeling. Trajectories of cylindrical particles settling in stagnant water are filmed from two directions in order to derive detailed information on their mo...

  17. Tunable Omnidirectional Surface Plasmon Resonance in Cylindrical Plasmonic Structure

    Institute of Scientific and Technical Information of China (English)

    WANG Yi; WANG Bing; ZHOU Zhi-Ping

    2008-01-01

    @@ The tunable omnidirectional surface plasmon resonance in the optical range is theoretically demonstrated in a cylindrical plasmonic crystal by using rigorous coupled-wave analysis.The cylindrical plasmonic crystal consists of an infinite chain of two-dimensional cylindrical metal-dielectric-dielectric-metal structures.The dispersion relation of the cylindrical plasmonic crystal is obtained by calculating the absorptance as a function of a TM-polarized incident plane wave and its in-plane wave vector.The omnidirectional surface plasmon resonance can be tuned from UV region to visible region by adjusting the thickness of the cylindrical dielectric layers.The absorption spectrum of the infinite chain of nanocylinders is also investigated for comparison.

  18. Damage Detection by the Mode-Selectable Magnetostrictive Transducer for Cylindrical Ferromagnetic Waveguides

    Science.gov (United States)

    Kim, Youngkyu; Kim, Ikkyu; Kim, Yoon Young

    2004-02-01

    In recent years, ultrasonic inspection techniques adopting magnetostrictive effects have received much attention, because they are non-destructive and require no direct physical contact with target systems. By selecting the desired wave mode and thus rejecting the unwanted modes amongst propagating waves in cylindrical ferromagnetic waveguides, we can effectively detect various types of flaws. However, a bending wave mode selecting technique, in particular, has not been fully developed yet. The purpose of this work is to present a technique to select either bending or longitudinal waves alone from compound waves propagating in ferromagnetic cylindrical waveguide. To achieve this goal, a new bias magnet configuration suitable for bending mode selection is suggested. The experimental results verify the effectiveness of the proposed method.

  19. Lead Poisoning

    Science.gov (United States)

    Lead is a metal that occurs naturally in the earth's crust. Lead can be found in all parts of our ... from human activities such as mining and manufacturing. Lead used to be in paint; older houses may ...

  20. Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen

    Directory of Open Access Journals (Sweden)

    Saluja SS

    2014-11-01

    Full Text Available Sandeep S Saluja,1 Douglas J Hanlon,1 Fiona A Sharp,2 Enping Hong,2 David Khalil,1 Eve Robinson,1 Robert Tigelaar,1 Tarek M Fahmy,2,3 Richard L Edelson1 1Department of Dermatology, Yale University School of Medicine, 2Department of Biomedical Engineering, Yale University, 3Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA Abstract: Targeting antigen to dendritic cells (DCs is a powerful and novel strategy for vaccination. Priming or loading DCs with antigen controls whether subsequent immunity will develop and hence whether effective vaccination can be achieved. The goal of our present work was to increase the potency of DC-based antitumor vaccines by overcoming inherent limitations associated with antigen stability and cross-presentation. Nanoparticles prepared from the biodegradable polymer poly(lactic-co-glycolic acid have been extensively used in clinical settings for drug delivery and are currently the subject of intensive investigation as antigen delivery vehicles for vaccine applications. Here we describe a nanoparticulate delivery system with the ability to simultaneously carry a high density of protein-based antigen while displaying a DC targeting ligand on its surface. Utilizing a targeting motif specific for the DC-associated surface ligand DEC-205, we show that targeted nanoparticles encapsulating a MART-127–35 peptide are both internalized and cross-presented with significantly higher efficiency than isotype control-coated nanoparticles in human cells. In addition, the DEC-205-labeled nanoparticles rapidly escape from the DC endosomal compartment and do not colocalize with markers of early (EEA-1 or late endosome/lysosome (LAMP-1. This indicates that encapsulated antigens delivered by nanoparticles may have direct access to the class I cytoplasmic major histocompatibility complex loading machinery, overcoming the need for “classical” cross-presentation and facilitating heightened DC

  1. Toward the Rational Design of Galactosylated Glycoclusters That Target Pseudomonas aeruginosa Lectin A (LecA): Influence of Linker Arms That Lead to Low-Nanomolar Multivalent Ligands.

    Science.gov (United States)

    Wang, Shuai; Dupin, Lucie; Noël, Mathieu; Carroux, Cindy J; Renaud, Louis; Géhin, Thomas; Meyer, Albert; Souteyrand, Eliane; Vasseur, Jean-Jacques; Vergoten, Gérard; Chevolot, Yann; Morvan, François; Vidal, Sébastien

    2016-08-01

    Anti-infectious strategies against pathogen infections can be achieved through antiadhesive strategies by using multivalent ligands of bacterial virulence factors. LecA and LecB are lectins of Pseudomonas aeruginosa implicated in biofilm formation. A series of 27 LecA-targeting glycoclusters have been synthesized. Nine aromatic galactose aglycons were investigated with three different linker arms that connect the central mannopyranoside core. A low-nanomolar (Kd =19 nm, microarray) ligand with a tyrosine-based linker arm could be identified in a structure-activity relationship study. Molecular modeling of the glycoclusters bound to the lectin tetramer was also used to rationalize the binding properties observed.

  2. Variational Formulation of E & M Particle Simulation Algorithms in Cylindrical Geometry using an Angular Modal Decomposition

    CERN Document Server

    Stamm, A B

    2014-01-01

    Taking advantage of the flexibility of the variational method with coordinate transformations, we derive a self-consistent set of equations of motion from a discretized Lagrangian to study kinetic plasmas using a Fourier decomposed cylindrical coordinate system. The phase-space distribution function was reduced to a collection of finite-sized macro-particles of arbitrary shape moving on a virtual Cartesian grid. However, the discretization of field quantities was performed in cylindrical coordinates and decomposed into a truncated Fourier series in angle. A straightforward finite element interpolation scheme is used to transform between the two grids. The equations of motion were then obtained by demanding the action be stationary. The primary advantage of the variational approach is preservation of Lagrangian symmetries. In the present case, this leads to exact energy conservation, thus avoiding possible difficulties with grid heating.

  3. Synchrotron and Smith-Purcell radiations from a charge rotating around a cylindrical grating

    CERN Document Server

    Saharian, A A; Mkrtchyan, A R; Khachatryan, B V

    2016-01-01

    We investigate the radiation from a charge rotating around conductors with cylindrical symmetry. First the problem is considered with a charge rotating around a conducting cylinder immersed in a homogeneous medium. The surface charge and current densities induced on the cylinder surface are evaluated. A formula is derived for the spectral-angular density of the radiation intensity. In the second part, we study the radiation for a charge rotating around a diffraction grating on a cylindrical surface with metallic strips parallel to the cylinder axis. The effect of the grating on the radiation intensity is approximated by the surface currents induced on the strips by the field of the rotating charge. The expressions are derived for the electric and magnetic fields and for the angular density of the radiation intensity on a given harmonic. We show that the interference between the synchrotron and Smith-Purcell radiations may lead to interesting features. In particular, the behavior of the radiation intensity on ...

  4. Self-formed cavity quantum electrodynamics in coupled dipole cylindrical-waveguide systems.

    Science.gov (United States)

    Afshar V, S; Henderson, M R; Greentree, A D; Gibson, B C; Monro, T M

    2014-05-01

    An ideal optical cavity operates by confining light in all three dimensions. We show that a cylindrical waveguide can provide the longitudinal confinement required to form a two dimensional cavity, described here as a self-formed cavity, by locating a dipole, directed along the waveguide, on the interface of the waveguide. The cavity resonance modes lead to peaks in the radiation of the dipole-waveguide system that have no contribution due to the skew rays that exist in longitudinally invariant waveguides and reduce their Q-factor. Using a theoretical model, we evaluate the Q-factor and modal volume of the cavity formed by a dipole-cylindrical-waveguide system and show that such a cavity allows access to both the strong and weak coupling regimes of cavity quantum electrodynamics.

  5. Numerical Simulation Study on the Surface Deflection of Cylindrical Shallow Shell

    Institute of Scientific and Technical Information of China (English)

    XING Zhongwen; BAO Jun; LIU Zhongyuan; YANG Yuying; SUN Zhenzhong

    2006-01-01

    The increasing applications of new materials such as high strength low alloy (HSAL) steels and aluminum alloy sheets have lead to greater focus on the surface deflections of auto body panels in the automobile industry in recent years. The finite element models of cylindrical shallow shell that can represent auto body panels are established. Numerical simulations of forming and unloading of cylindrical shallow shell are carried out. And a measurement and evaluation method of the surface deflection is introduced. The simulations of surface deflections with various blank holding forces (BHF) show great agreement with the experimental results. The influence laws of sheet thickness and material properties such as yield strength σs, strain-hardening exponent n, anisotropy parameter r and strength coefficient k on the surface deflection are achieved by simulations, which give a basic reference for controlling surface deflections.

  6. A robust approach for analysing dispersion of elastic waves in an orthotropic cylindrical shell

    Science.gov (United States)

    Kaplunov, J.; Nobili, A.

    2017-08-01

    Dispersion of elastic waves in a thin orthotropic cylindrical shell is considered, within the framework of classical 2D Kirchhoff-Love theory. In contrast to direct multi-parametric analysis of the lowest propagating modes, an alternative robust approach is proposed that simply requires evaluation of the evanescent modes (quasi-static edge effect), which, at leading order, do not depend on vibration frequency. A shortened dispersion relation for the propagating modes is then derived by polynomial division and its accuracy is numerically tested against the full Kirchhoff-Love dispersion relation. It is shown that the same shortened relation may be also obtained from a refined dynamic version of the semi-membrane theory for cylindrical shells. The presented results may be relevant for modelling various types of nanotubes which, according to the latest experimental findings, possess strong material anisotropy.

  7. Dispersion relations and bending losses of cylindrical and spherical shells, slabs, and slot waveguides

    CERN Document Server

    Kozyreff, Gregory

    2016-01-01

    We derive formulas for Whispering Gallery Mode resonances and bending losses in infinite cylindrical dielectric shells and sets of concentric cylindrical shells. The formulas also apply to spherical shells and to sections of bent waveguides. The derivation is based on a WKB treatment of Helmholtz equation and can in principle be extended to any number of concentric shells. A distinctive limit analytically arises in the analysis when two shells are brought at very close distance to one another. In that limit, the two shells act as a slot waveguide. If the two shells are sufficiently apart, we identify a structural resonance between the individual shells, which can either lead to a substantial enhancement or suppression of radiation losses.

  8. Performance Analysis of Functionally Graded Coatings in Contact with Cylindrical Rollers

    Directory of Open Access Journals (Sweden)

    Reza Jahedi

    2015-01-01

    Full Text Available This work presents finite element analysis (FEA and results for rolling contact of a cylindrical roller on an elastic substrate coated by functionally graded material (FGM. The rolling process and the graded coating material property and layers arrangement are modeled using finite element codes which lead to a new methodology. This novel methodology provides a trend in determining surface contact stresses, deformations, contact zones, and energy dissipation through the contact area. Effects of stiffness ratio, friction, and exponentially variation of material property on the contact stresses and deformations are studied. Some of the results are verified with analytical solutions. The study results may be beneficial in graded coated cylindrical components analysis against rolling contact failure and wear.

  9. Dispersion relations and bending losses of cylindrical and spherical shells, slabs, and slot waveguides.

    Science.gov (United States)

    Kozyreff, Gregory; Acharyya, Nirmalendu

    2016-12-12

    We derive formulas for whispering gallery mode resonances and bending losses in infinite cylindrical dielectric shells and sets of concentric cylindrical shells. The formulas also apply to spherical shells and to sections of bent waveguides. The derivation is based on a Wentzel-Kramers-Brillouin (WKB) treatment of Helmholtz equation and can in principle be extended to any number of concentric shells. A distinctive limit analytically arises in the analysis when two shells are brought at very close distance to one another. In that limit, the two shells act as a slot waveguide. If the two shells are sufficiently apart, we identify a structural resonance between the individual shells, which can either lead to a substantial enhancement or suppression of radiation losses.

  10. Converging cylindrical shocks in ideal magnetohydrodynamics

    KAUST Repository

    Pullin, D. I.

    2014-09-01

    We consider a cylindrically symmetrical shock converging onto an axis within the framework of ideal, compressible-gas non-dissipative magnetohydrodynamics (MHD). In cylindrical polar co-ordinates we restrict attention to either constant axial magnetic field or to the azimuthal but singular magnetic field produced by a line current on the axis. Under the constraint of zero normal magnetic field and zero tangential fluid speed at the shock, a set of restricted shock-jump conditions are obtained as functions of the shock Mach number, defined as the ratio of the local shock speed to the unique magnetohydrodynamic wave speed ahead of the shock, and also of a parameter measuring the local strength of the magnetic field. For the line current case, two approaches are explored and the results compared in detail. The first is geometrical shock-dynamics where the restricted shock-jump conditions are applied directly to the equation on the characteristic entering the shock from behind. This gives an ordinary-differential equation for the shock Mach number as a function of radius which is integrated numerically to provide profiles of the shock implosion. Also, analytic, asymptotic results are obtained for the shock trajectory at small radius. The second approach is direct numerical solution of the radially symmetric MHD equations using a shock-capturing method. For the axial magnetic field case the shock implosion is of the Guderley power-law type with exponent that is not affected by the presence of a finite magnetic field. For the axial current case, however, the presence of a tangential magnetic field ahead of the shock with strength inversely proportional to radius introduces a length scale R = √μ0/p0 I/(2π) where I is the current, μ0 is the permeability, and p0 is the pressure ahead of the shock. For shocks initiated at r ≫ R, shock convergence is first accompanied by shock strengthening as for the strictly gas-dynamic implosion. The diverging magnetic field then

  11. Converging cylindrical shocks in ideal magnetohydrodynamics

    Science.gov (United States)

    Pullin, D. I.; Mostert, W.; Wheatley, V.; Samtaney, R.

    2014-09-01

    We consider a cylindrically symmetrical shock converging onto an axis within the framework of ideal, compressible-gas non-dissipative magnetohydrodynamics (MHD). In cylindrical polar co-ordinates we restrict attention to either constant axial magnetic field or to the azimuthal but singular magnetic field produced by a line current on the axis. Under the constraint of zero normal magnetic field and zero tangential fluid speed at the shock, a set of restricted shock-jump conditions are obtained as functions of the shock Mach number, defined as the ratio of the local shock speed to the unique magnetohydrodynamic wave speed ahead of the shock, and also of a parameter measuring the local strength of the magnetic field. For the line current case, two approaches are explored and the results compared in detail. The first is geometrical shock-dynamics where the restricted shock-jump conditions are applied directly to the equation on the characteristic entering the shock from behind. This gives an ordinary-differential equation for the shock Mach number as a function of radius which is integrated numerically to provide profiles of the shock implosion. Also, analytic, asymptotic results are obtained for the shock trajectory at small radius. The second approach is direct numerical solution of the radially symmetric MHD equations using a shock-capturing method. For the axial magnetic field case the shock implosion is of the Guderley power-law type with exponent that is not affected by the presence of a finite magnetic field. For the axial current case, however, the presence of a tangential magnetic field ahead of the shock with strength inversely proportional to radius introduces a length scale R=sqrt{μ _0/p_0} I/(2 π ) where I is the current, μ0 is the permeability, and p0 is the pressure ahead of the shock. For shocks initiated at r ≫ R, shock convergence is first accompanied by shock strengthening as for the strictly gas-dynamic implosion. The diverging magnetic field

  12. Attenuation of Telomerase Activity by siRNA Targeted Telomerase RNA Leads to Apoptosis and Inhibition of Proliferation in Human Renal Carcinoma Cells

    Institute of Scientific and Technical Information of China (English)

    Rumin Wen; Junjie Liu; Wang Li; Wenfa Yang; Lijun Mao; Junnian Zheng

    2006-01-01

    OBJECTIVE Telomerase is an attractive molecular target for cancer therapy because the activation of telomerase is one of the key steps in cell immortalization and carcinogenesis. RNA interference using small-interfering RNA (siRNA) has been demonstrated to be an effective method for inhibiting the expression of a given gene in human cells. The aim of the present study was to investigate whether inhibition of telomerase activity by siRNA targeted against human telomerase RNA (hTR) can inhibit proliferation and induce apoptotic cell death in human renal carcinoma cells(HRCCs).METHODS The siRNA duplexes for hTR were synthesized and 786-O HRCCs were transfected with different concentrations of hTR-siRNA. The influence on the hTR mRNA level, telomerase activity, as well as the effect on cell proliferation and apoptosis was examined.RESULTS Anti-hTR siRNA treatment of HRCCs resulted in specific reduction of hTR mRNA and inhibition of telomerase activity. Additionally,significant inhibition of proliferation and induction of apoptosis were observed.CONCLUSION siRNA against the hTR gene can inhibit proliferation and induce apoptosis by blocking telomerase activity of HRCCs. Specific hTR inhibition by siRNA represents a promising new option for renal cancer treatment.

  13. Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS.

    Science.gov (United States)

    Su, Zhaoming; Zhang, Yongjie; Gendron, Tania F; Bauer, Peter O; Chew, Jeannie; Yang, Wang-Yong; Fostvedt, Erik; Jansen-West, Karen; Belzil, Veronique V; Desaro, Pamela; Johnston, Amelia; Overstreet, Karen; Oh, Seok-Yoon; Todd, Peter K; Berry, James D; Cudkowicz, Merit E; Boeve, Bradley F; Dickson, Dennis; Floeter, Mary Kay; Traynor, Bryan J; Morelli, Claudia; Ratti, Antonia; Silani, Vincenzo; Rademakers, Rosa; Brown, Robert H; Rothstein, Jeffrey D; Boylan, Kevin B; Petrucelli, Leonard; Disney, Matthew D

    2014-09-03

    A repeat expansion in C9ORF72 causes frontotemporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). RNA of the expanded repeat (r(GGGGCC)exp) forms nuclear foci or undergoes repeat-associated non-ATG (RAN) translation, producing "c9RAN proteins." Since neutralizing r(GGGGCC)exp could inhibit these potentially toxic events, we sought to identify small-molecule binders of r(GGGGCC)exp. Chemical and enzymatic probing of r(GGGGCC)8 indicate that it adopts a hairpin structure in equilibrium with a quadruplex structure. Using this model, bioactive small molecules targeting r(GGGGCC)exp were designed and found to significantly inhibit RAN translation and foci formation in cultured cells expressing r(GGGGCC)66 and neurons transdifferentiated from fibroblasts of repeat expansion carriers. Finally, we show that poly(GP) c9RAN proteins are specifically detected in c9ALS patient cerebrospinal fluid. Our findings highlight r(GGGGCC)exp-binding small molecules as a possible c9FTD/ALS therapeutic and suggest that c9RAN proteins could potentially serve as a pharmacodynamic biomarker to assess efficacy of therapies that target r(GGGGCC)exp.

  14. Surface tension and long range corrections of cylindrical interfaces

    Energy Technology Data Exchange (ETDEWEB)

    Bourasseau, E. [CEA/DAM DIF, F-91297 Arpajon Cedex (France); Malfreyt, P. [Université Clermont Auvergne, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, F-63000 Clermont-Ferrand (France); Ghoufi, A., E-mail: aziz.ghoufi@univ-rennes1.fr [Institut de Physique de Rennes, UMR 6251 CNRS, Université de Rennes 1, 263 avenue Général Leclerc, 35042 Rennes (France)

    2015-12-21

    The calculation of the surface tension of curved interfaces has been deeply investigated from molecular simulation during this last past decade. Recently, the thermodynamic Test-Area (TA) approach has been extended to the calculation of surface tension of curved interfaces. In the case of the cylindrical vapour-liquid interfaces of water and Lennard-Jones fluids, it was shown that the surface tension was independent of the curvature of the interface. In addition, the surface tension of the cylindrical interface is higher than that of the planar interface. Molecular simulations of cylindrical interfaces have been so far performed (i) by using a shifted potential, (ii) by means of large cutoff without periodic boundary conditions, or (iii) by ignoring the long range corrections to the surface tension due to the difficulty to estimate them. Indeed, unlike the planar interfaces there are no available operational expressions to consider the tail corrections to the surface tension of cylindrical interfaces. We propose here to develop the long range corrections of the surface tension for cylindrical interfaces by using the non-exponential TA (TA2) method. We also extend the formulation of the Mecke-Winkelmann corrections initially developed for planar surfaces to cylindrical interfaces. We complete this study by the calculation of the surface tension of cylindrical surfaces of liquid tin and copper using the embedded atom model potentials.

  15. Observing of tree trunks and other cylindrical objects using GPR

    Science.gov (United States)

    Jezova, Jana; Lambot, Sebastien

    2016-04-01

    Trees are a part of our everyday life, hence it is important to prevent their collapse to protect people and urban infrastructures. It is also important to characterize tree wood properties for usages in construction. In order to investigate internal parts of tree trunks non-invasively, ground-penetrating radar (GPR), or in this case, ultra-wideband microwave radar as a general tool, appears to be a very promising technology. Nevertheless, tree trunk tomography using microwave radar is a complicated task due to the circular shape of the trunk and the very complex (heterogeneous and anisotropic) internal structures of the trunk. Microwave sensing of tree trunks is also complicated due to the electromagnetic properties of living wood, which strongly depend on water content, density and temperature of wood. The objective of this study is to describe tree trunk radar cross sections including specific features originating from the particular circumferential data acquisition geometry. In that respect, three experiments were performed: (1) numerical simulations using a finite-difference time-domain software, namely, gprMax 2D, (2) measurements on a simplified laboratory trunk model including plastic and cardboard pipes, sand and air, and (3) measurements over a real tree trunk. The analysis was further deepened by considering: (1) common zero-offset reflection imaging, (2) imaging with a planar perfect electrical conductor (PEC) at the opposite side of the trunk, and (3) imaging with a PEC arc at the opposite side of the trunk. Furthermore, the shape of the reflection curve of a cylindrical target was analytically derived based on the straight-ray propagation approximation. Subsequently, the total internal reflection (TIR) phenomenon occurring in cylindrical objects was observed and analytically described. Both the straight-ray reflection curve and TIR were well observed on the simulated and laboratory radar data. A comparison between all experiments and radar

  16. Functional evolution of quantum cylindrical waves

    CERN Document Server

    Cho, D H J; Cho, Demian H.J.; Varadarajan, Madhavan

    2006-01-01

    Kucha{\\v{r}} showed that the quantum dynamics of (1 polarization) cylindrical wave solutions to vacuum general relativity is determined by that of a free axially-symmetric scalar field along arbitrary axially-symmetric foliations of a fixed flat 2+1 dimensional spacetime. We investigate if such a dynamics can be defined {\\em unitarily} within the standard Fock space quantization of the scalar field. Evolution between two arbitrary slices of an arbitrary foliation of the flat spacetime can be built out of a restricted class of evolutions (and their inverses). The restricted evolution is from an initial flat slice to an arbitrary (in general, curved) slice of the flat spacetime and can be decomposed into (i) `time' evolution in which the spatial Minkowskian coordinates serve as spatial coordinates on the initial and the final slice, followed by (ii) the action of a spatial diffeomorphism of the final slice on the data obtained from (i). We show that although the functional evolution of (i) is unitarily implemen...

  17. Technology Selections for Cylindrical Compact Fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Jeffrey A. Phillips

    2010-10-01

    A variety of process approaches are available and have been used historically for manufacture of cylindrical fuel compacts. The jet milling, fluid bed overcoating, and hot press compacting approach being adopted in the U.S. AGR Fuel Development Program for scale-up of the compacting process involves significant paradigm shifts from historical approaches. New methods are being pursued because of distinct advantages in simplicity, yield, and elimination of process mixed waste. Recent advances in jet milling technology allow simplified dry matrix powder preparation. The matrix preparation method is well matched with patented fluid bed powder overcoating technology recently developed for the pharmaceutical industry and directly usable for high density fuel particle matrix overcoating. High density overcoating places fuel particles as close as possible to their final position in the compact and is matched with hot press compacting which fully fluidizes matrix resin to achieve die fill at low compacting pressures and without matrix end caps. Overall the revised methodology provides a simpler process that should provide very high yields, improve homogeneity, further reduce defect fractions, eliminate intermediate grading and QC steps, and allow further increases in fuel packing fractions.

  18. Cylindrical shell buckling through strain hardening

    Energy Technology Data Exchange (ETDEWEB)

    Bandyopadhyay, K.; Xu, J.; Shteyngart, S. [Brookhaven National Lab., Upton, NY (United States); Gupta, D. [USDOE, Germantown, MD (United States)

    1995-04-01

    Recently, the authors published results of plastic buckling analysis of cylindrical shells. Ideal elastic-plastic material behavior was used for the analysis. Subsequently, the buckling analysis program was continued with the realistic stress-strain relationship of a stainless steel alloy which does not exhibit a clear yield point. The plastic buckling analysis was carried out through the initial stages of strain hardening for various internal pressure values. The computer program BOSOR5 was used for this purpose. Results were compared with those obtained from the idealized elastic-plastic relationship using the offset stress level at 0.2% strain as the yield stress. For moderate hoop stress values, the realistic stress-grain case shows a slight reduction of the buckling strength. But, a substantial gain in the buckling strength is observed as the hoop stress approaches the yield strength. Most importantly, the shell retains a residual strength to carry a small amount of axial compressive load even when the hoop stress has exceeded the offset yield strength.

  19. Lead Toxicity

    Science.gov (United States)

    ... including some imported jewelry. What are the health effects of lead? • More commonly, lower levels of lead in children over time may lead to reduced IQ, slow learning, Attention Deficit Hyperactivity Disorder (ADHD), or behavioral issues. • Lead also affects other ...

  20. Timed and targeted differential regulation of nitric oxide synthase (NOS) and anti-NOS genes by reward conditioning leading to long-term memory formation.

    Science.gov (United States)

    Korneev, Sergei A; Straub, Volko; Kemenes, Ildikó; Korneeva, Elena I; Ott, Swidbert R; Benjamin, Paul R; O'Shea, Michael

    2005-02-02

    In a number of neuronal models of learning, signaling by the neurotransmitter nitric oxide (NO), synthesized by the enzyme neuronal NO synthase (nNOS), is essential for the formation of long-term memory (LTM). Using the molluscan model system Lymnaea, we investigate here whether LTM formation is associated with specific changes in the activity of members of the NOS gene family: Lym-nNOS1, Lym-nNOS2, and the antisense RNA-producing pseudogene (anti-NOS). We show that expression of the Lym-nNOS1 gene is transiently upregulated in cerebral ganglia after conditioning. The activation of the gene is precisely timed and occurs at the end of a critical period during which NO is required for memory consolidation. Moreover, we demonstrate that this induction of the Lym-nNOS1 gene is targeted to an identified modulatory neuron called the cerebral giant cell (CGC). This neuron gates the conditioned feeding response and is an essential part of the neural network involved in LTM formation. We also show that the expression of the anti-NOS gene, which functions as a negative regulator of nNOS expression, is downregulated in the CGC by training at 4 h after conditioning, during the critical period of NO requirement. This appears to be the first report of the timed and targeted differential regulation of the activity of a group of related genes involved in the production of a neurotransmitter that is necessary for learning, measured in an identified neuron of known function. We also provide the first example of the behavioral regulation of a pseudogene.

  1. Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis.

    Science.gov (United States)

    Wang, Limin; Gallo, Kathleen A; Conrad, Susan E

    2013-08-01

    Estrogen receptor (ER)-positive tumors represent the most common type of breast cancer, and ER-targeted therapies such as antiestrogens and aromatase inhibitors have therefore been widely used in breast cancer treatment. While many patients have benefited from these therapies, both innate and acquired resistance continue to be causes of treatment failure. Novel targeted therapeutics that could be used alone or in combination with endocrine agents to treat resistant tumors or to prevent their development are therefore needed. In this report, we examined the effects of inhibiting mixed-lineage kinase (MLK) activity on ER-positive breast cancer cells and non-tumorigenic mammary epithelial cells. Inhibition of MLK activity with the pan-MLK inhibitor CEP-1347 blocked cell cycle progression in G2 and early M phase, and induced apoptosis in three ER-positive breast cancer cell lines, including one with acquired antiestrogen resistance. In contrast, it had no effect on the cell cycle or apoptosis in two non-tumorigenic mammary epithelial cell lines. CEP-1347 treatment did not decrease the level of active ERK or p38 in any of the cell lines tested. However, it resulted in decreased JNK and NF-κB activity in the breast cancer cell lines. A JNK inhibitor mimicked the effects of CEP-1347 in breast cancer cells, and overexpression of c-Jun rescued CEP-1347-induced Bax expression. These results indicate that proliferation and survival of ER-positive breast cancer cells are highly dependent on MLK activity, and suggest that MLK inhibitors may have therapeutic efficacy for ER-positive breast tumors, including ones that are resistant to current endocrine therapies.

  2. Buckling localization in a cylindrical panel under axial compression

    DEFF Research Database (Denmark)

    Tvergaard, Viggo; Needleman, A.

    2000-01-01

    Localization of an initially periodic buckling pattern is investigated for an axially compressed elastic-plastic cylindrical panel of the type occurring between axial stiffeners on cylindrical shells. The phenomenon of buckling localization and its analogy with plastic flow localization in tensile...... test specimens is discussed in general. For the cylindrical panel, it is shown that buckling localization develops shortly after a maximum load has been attained, and this occurs for a purely elastic panel as well as for elastic-plastic panels. In a case where localization occurs after a load maximum...

  3. Electromagnetic Cylindrical Transparent Devices with Irregular Cross Section

    Directory of Open Access Journals (Sweden)

    C. Yang

    2010-04-01

    Full Text Available Electromagnetic transparent device is very important for antenna protection. In this paper, the material parameters for the cylindrical transparent devices with arbitrary cross section are developed based on the coordinate transformation. The equivalent two-dimensional (2D transparent devices under TE plane and cylindrical wave irradiation is designed and studied by full-wave simulation, respectively. It shows that although the incident waves are distorted in the transformation region apparently, they return to the original wavefronts when passing through the device. All theoretical and numerical results validate the material parameters for the cylindrical transparent devices with arbitrary cross section we developed.

  4. New cylindrical gravitational soliton waves and gravitational Faraday rotation

    CERN Document Server

    Tomizawa, Shinya

    2013-01-01

    In terms of gravitational solitons, we study gravitational non-linear effects of gravitational solitary waves such as Faraday rotation. Applying the Pomeransky's procedure for inverse scattering method, which has been recently used for constructing stationary black hole solutions in five dimensions to a cylindrical spacetime in four dimensions, we construct a new cylindrically symmetric soliton solution. This is the first example to be applied to the cylindrically symmetric case. In particular, we clarify the difference from the Tomimatsu's single soliton solution, which was constructed by the Belinsky-Zakharov's procedure.

  5. γ-ray self-absorption of cylindrical fissile material

    Institute of Scientific and Technical Information of China (English)

    HUANG Yong-Yi; CHENG Yi-Ying; TIAN Dong-Feng; LU Fu-Quan; YANG Fu-Jia

    2005-01-01

    The self-absorption of γ-ray emitted from cylindrical fissile materials, such as 235U and 239Pu, does not possess spherical symmetry. The analytical formulae of self-absorption for γ-ray throughout the cylinder have been obtained. The intensity of γ-ray is a function of γ-ray outgoing directions and cylindrical configurations, accordingly one can acquire the information about geometrical configuration of cylindrical fissile materials through multi-location measurements. Further more, the method is given in this article. The result can be applied to the fissile material safeguard, such as nuclear monitoring and verifying.

  6. Plasmonic Bloch oscillations in cylindrical metal-dielectric waveguide arrays.

    Science.gov (United States)

    Shiu, Ruei-Cheng; Lan, Yung-Chiang; Chen, Chin-Min

    2010-12-01

    This study investigates plasmonic Bloch oscillations (PBOs) in cylindrical metal-dielectric waveguide arrays (MDWAs) by performing numerical simulations and theoretical analyses. Optical conformal mapping is used to transform cylindrical MDWAs into equivalent chirped structures with permittivity and permeability gradients across the waveguide arrays, which is caused by the curvature of the cylindrical waveguide. The PBOs are attributed to the transformed structure. The period of oscillation increases with the wavelength of the incident Gaussian beam. However, the amplitude of oscillation is almost independent of wavelength.

  7. Cylindrical array luminescent solar concentrators: performance boosts by geometric effects.

    Science.gov (United States)

    Videira, Jose J H; Bilotti, Emiliano; Chatten, Amanda J

    2016-07-11

    This paper presents an investigation of the geometric effects within a cylindrical array luminescent solar concentrator (LSC). Photon concentration of a cylindrical LSC increases linearly with cylinder length up to 2 metres. Raytrace modelling on the shading effects of circles on their neighbours demonstrates effective incident light trapping in a cylindrical LSC array at angles of incidence between 60-70 degrees. Raytrace modelling with real-world lighting conditions shows optical efficiency boosts when the suns angle of incidence is within this angle range. On certain days, 2 separate times of peak optical efficiency can be attained over the course of sunrise-solar noon.

  8. Production yield of produced radioisotopes from 100 MeV proton beam on lead target for shielding analysis of large accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Oranj, Leila Mokhtari; Oh, Joo Hee; Jung, Nam Suk; Bae, O Ryun; Lee, Hee Seock [Div. of Advanced Nuclear Engineering, POSTECH, Pohang (Korea, Republic of)

    2014-11-15

    In this work, the production yield of major shielding material, a lead, was investigated using 100 MeV protons of KOMAC accelerator facility. For the analysis of the experimental data, the activity has been calculated using the FLUKA Monte Carlo code and analytical methods. The cross section data and the stopping power in the irradiated assembly were calculated by TALYS and SRIM codes in the analytical method, respectively. Consequently, the experimental production yield of produced radioisotopes was compared with the data that are based on Monte Carlo calculations and analytical studies. In this research, the {sup nat}Pb(p, x) reaction was studied using experimental measurements, Monte Carlo simulations and analytical methods. Rereading to the experimental measurements, we demonstrate that both Monte Carlo simulation and analytical methods could be useful tools for the estimation of production yield of this reaction.

  9. Superconductivity of lead

    Energy Technology Data Exchange (ETDEWEB)

    Boorse, H.A.; Cook, D.B.; Zemansky, W.M.

    1950-06-01

    Numerous determinations of the zero-field transition temperature of lead have been made. All of these observations except that of Daunt were made by the direct measurement of electrical resistance. Daunt`s method involved the shielding effect of persistent currents in a hollow cylinder. In the authors work on columbium to be described in a forthcoming paper an a.c. induction method was used for the measurement of superconducting transitions. The superconductor was mounted as a cylindrical core of a coil which functioned as the secondary of a mutual inductance. The primary coil was actuated by an oscillator which provided a maximum a.c. field within the secondary of 1.5 oersteds at a frequency of 1000 cycles per second. The secondary e.m.f. which was dependent for its magnitude on the permeability of the core was amplified, rectifie, and observed on a recording potentiometer. During the application of this method to the study of columbium it appeared that a further check on the zero-field transition temperature of lead would be worth while especially if agreement between results for very pure samples could be obtained using this method. Such result would help in establishing the lead transition temperature as a reasonably reproducible reference point in the region between 4 deg and 10 deg K.

  10. A human polymorphism affects NEDD4L subcellular targeting by leading to two isoforms that contain or lack a C2 domain

    Directory of Open Access Journals (Sweden)

    Lalouel Jean-Marc

    2009-04-01

    Full Text Available Abstract Background Ubiquitination serves multiple cellular functions, including proteasomal degradation and the control of stability, function, and intracellular localization of a wide variety of proteins. NEDD4L is a member of the HECT class of E3 ubiquitin ligases. A defining feature of NEDD4L protein isoforms is the presence or absence of an amino-terminal C2 domain, a class of subcellular, calcium-dependent targeting domains. We previously identified a common variant in human NEDD4L that generates isoforms that contain or lack a C2 domain. Results To address the potential functional significance of the NEDD4L common variant on NEDD4L subcellular localization, NEDD4L isoforms that either contained or lacked a C2 domain were tagged with enhanced green fluorescent protein, transfected into Xenopus laevis kidney epithelial cells, and imaged by performing confocal microscopy on live cells. We report that the presence or absence of this C2 domain exerts differential effects on the subcellular distribution of NEDD4L, the ability of C2 containing and lacking NEDD4L isoforms to mobilize in response to a calcium stimulus, and the intracellular transport of subunits of the NEDD4L substrate, ENaC. Furthermore, the ability of the C2-containing isoform to influence β-ENaC mobilization from intracellular pools involves the NEDD4L active site for ubiquitination. We propose a model to account for the potential impact of this common genetic variant on protein function at the cellular level. Conclusion NEDD4L isoforms that contain or lack a C2 domain target different intracellular locations. Additionally, whereas the C2-containing NEDD4L isoform is capable of shuttling between the plasma membrane and intracellular compartments in response to calcium stimulus the C2-lacking isoform can not. The C2-containing isoform differentially affects the mobilization of ENaC subunits from intracellular pools and this trafficking step requires NEDD4L ubiquitin ligase

  11. Comparison of subjective comfort ratings between anatomically shaped and cylindrical handles.

    Science.gov (United States)

    Harih, Gregor; Dolšak, Bojan

    2014-07-01

    Most authors have provided diameter recommendations for cylindrical handle design in order to increase performance, avoid discomfort, and reduce the risk of cumulative trauma disorders. None of the studies has investigated the importance of determining the correct handle shape on the subjective comfort ratings, which could further improve the handles' ergonomics. Therefore, new methods based on a virtual hand model in its optimal power grasp posture have been developed in order to obtain customised handles with best fits for targeted subjects. Cylindrical and anatomically shaped handles were evaluated covering ten subjects by means of an extensive subjective comfort questionnaire. The results suggest large impact of the handle shape on the perceived subjective comfort ratings. Anatomically shaped handles were rated as being considerably more comfortable than cylindrical handles for almost all the subjective comfort predictors. They showed that handle shapes based on optimal power grasp postures can improve subjective comfort ratings, thus maximising performance. Future research should consider real conditions, since the comfort ratings can vary based on the specific task and by the tool selected for the task.

  12. MHD peristaltic transport of spherical and cylindrical magneto-nanoparticles suspended in water

    Directory of Open Access Journals (Sweden)

    F. M. Abbasi

    2015-07-01

    Full Text Available Advancements in the biomedical engineering have enhanced the usage of magnto-nanoparticles in improving the precision and efficiency of the magneto-drug delivery systems. Such systems make use of the externally applied magnetic fields to direct the drug towards a specific target in the human body. Peristalsis of magneto-nanofluids is of significant importance in such considerations. Hence peristaltic transport of Fe3O4-water nanofluid through a two-dimensional symmetric channel is analyzed in the presence of an externally applied constant magnetic field. Hamilton-Crosser’s model of the thermal conductivity is utilized in the problem development. The nanofluid saturates a non-uniform porous medium in which the porosity of the porous medium varies with the distance from the channel walls. Analysis is performed for the spherical and the cylindrical nanoparticles. Resulting system of equations is numerically solved. Impacts of sundry parameters on the axial velocity, temperature, pressure gradient and heat transfer rate at the boundary are examined. Comparison between the results for spherical and cylindrical nanoparticles is also presented. Results show that the nanoparticles volume fraction and the Hartman number have increasing effect on the pressure gradient throughout the peristaltic tract. Effective heat transfer rate at the boundary tends to enhance with an increase in the nanoparticles volume fraction. Use of spherical nanoparticles results in a higher value of axial velocity and the temperature at the center of channel when compared with the case of cylindrical nanoparticles.

  13. HAMS: High-Affinity Mass Spectrometry Screening. A High-Throughput Screening Method for Identifying the Tightest-Binding Lead Compounds for Target Proteins with No False Positive Identifications

    Science.gov (United States)

    Imaduwage, Kasun P.; Go, Eden P.; Zhu, Zhikai; Desaire, Heather

    2016-09-01

    A major challenge in drug discovery is the identification of high affinity lead compounds that bind a particular target protein; these leads are typically identified by high throughput screens. Mass spectrometry has become a detection method of choice in drug screening assays because the target and the ligand need not be modified. Label-free assays are advantageous because they can be developed more rapidly than assays requiring labels, and they eliminate the risk of the label interfering with the binding event. However, in commonly used MS-based screening methods, detection of false positives is a major challenge. Here, we describe a detection strategy designed to eliminate false positives. In this approach, the protein and the ligands are incubated together, and the non-binders are separated for detection. Hits (protein binders) are not detectable by MS after incubation with the protein, but readily identifiable by MS when the target protein is not present in the incubation media. The assay was demonstrated using three different proteins and hundreds of non-inhibitors; no false positive hits were identified in any experiment. The assay can be tuned to select for ligands of a particular binding affinity by varying the quantity of protein used and the immobilization method. As examples, the method selectively detected inhibitors that have Ki values of 0.2 μM, 50 pM, and 700 pM. These findings demonstrate that the approach described here compares favorably with traditional MS-based screening methods.

  14. HAMS: High-Affinity Mass Spectrometry Screening. A High-Throughput Screening Method for Identifying the Tightest-Binding Lead Compounds for Target Proteins with No False Positive Identifications

    Science.gov (United States)

    Imaduwage, Kasun P.; Go, Eden P.; Zhu, Zhikai; Desaire, Heather

    2016-11-01

    A major challenge in drug discovery is the identification of high affinity lead compounds that bind a particular target protein; these leads are typically identified by high throughput screens. Mass spectrometry has become a detection method of choice in drug screening assays because the target and the ligand need not be modified. Label-free assays are advantageous because they can be developed more rapidly than assays requiring labels, and they eliminate the risk of the label interfering with the binding event. However, in commonly used MS-based screening methods, detection of false positives is a major challenge. Here, we describe a detection strategy designed to eliminate false positives. In this approach, the protein and the ligands are incubated together, and the non-binders are separated for detection. Hits (protein binders) are not detectable by MS after incubation with the protein, but readily identifiable by MS when the target protein is not present in the incubation media. The assay was demonstrated using three different proteins and hundreds of non-inhibitors; no false positive hits were identified in any experiment. The assay can be tuned to select for ligands of a particular binding affinity by varying the quantity of protein used and the immobilization method. As examples, the method selectively detected inhibitors that have Ki values of 0.2 μM, 50 pM, and 700 pM. These findings demonstrate that the approach described here compares favorably with traditional MS-based screening methods.

  15. A mean curvature estimate for cylindrically bounded submanifolds

    CERN Document Server

    Alias, Luis J

    2010-01-01

    We extend the estimate obtained in [1] for the mean curvature of a cylindrically bounded proper submanifold in a product manifold with an Euclidean space as one factor to a general product ambient space endowed with a warped product structure.

  16. Cylindrical invisibility cloak with simplified material parameters is inherently visible.

    Science.gov (United States)

    Yan, Min; Ruan, Zhichao; Qiu, Min

    2007-12-07

    It was proposed that perfect invisibility cloaks can be constructed for hiding objects from electromagnetic illumination [J. B. Pendry, D. Schurig, and D. R. Smith, Science 312, 1780 (2006)10.1126/science.1125907]. The cylindrical cloaks experimentally demonstrated [D. Schurig, Science 314, 977 (2006)10.1126/science.1133628] and theoretically proposed [W. Cai, Nat. Photon. 1, 224 (2007)10.1038/nphoton.2007.28] have however simplified material parameters in order to facilitate easier realization as well as to avoid infinities in optical constants. Here we show that the cylindrical cloaks with simplified material parameters inherently allow the zeroth-order cylindrical wave to pass through the cloak as if the cloak is made of a homogeneous isotropic medium, and thus visible. To all high-order cylindrical waves, our numerical simulation suggests that the simplified cloak inherits some properties of the ideal cloak, but finite scatterings exist.

  17. Response of an electrostatic probe for a right cylindrical spacer

    DEFF Research Database (Denmark)

    Rerup, T; Crichton, George C; McAllister, Iain Wilson

    1994-01-01

    During the last decade many experimental studies of surface charge phenomena have been undertaken employing right cylindrical spacers. Measurement of the surface charge was performed using small electrostatic field probes to scan across the dielectric surface. Charges are electrostatically induced...

  18. Cylindrically symmetric Einstein-Yang-Mills-Higgs gauge configurations.

    Science.gov (United States)

    Mondaini, R. P.

    1985-02-01

    Two solutions are obtained for coupled Einstein-Yang-Mills-Higgs fields with cylindrical symmetry and rigid rotation. The Higgs fields are responsible for the creation of singularities and infinite energy densities at the cylinder's axis.

  19. DETERMINATION OF ECONOMIC SIZES FOR RC CYLINDRICAL WATER STORAGE TANKS

    Directory of Open Access Journals (Sweden)

    Güneş KOZLUCA

    2007-03-01

    Full Text Available Water storage tanks are built in different shapes and sizes according to needs. Designs of water storage tanks with low costs are quite important for the national economy. Cylindrical and sphere tanks are the most economic types of tanks in terms of material cost. In this study several cylindrical tank designs are made. Then most economic tank radius – tank height ratio is searched by simply changing thickness, height and the radius of the tank considered. Storage capacity of these cylindrical tanks are all the same. All these reinforced tanks have cylindrical reinforced concrete walls fixed at the bottom and free top edge without roof. It is thought that tanks constructed with this optimal ratio will be beneficial.

  20. External Cylindrical Nozzle with Controlled Vacuum

    Directory of Open Access Journals (Sweden)

    V. N. Pil'gunov

    2015-01-01

    Full Text Available There is a developed design of the external cylindrical nozzle with a vacuum camera. The paper studies the nozzle controllability of flow rate via regulated connection of the evacuated chamber to the atmosphere through an air throttle. Working capacity of the nozzle with inlet round or triangular orifice are researched. The gap is provided in the nozzle design between the external wall of the inlet orifice and the end face of the straight case in the nozzle case. The presented mathematical model of the nozzle with the evacuated chamber allows us to estimate the expected vacuum amount in the compressed section of a stream and maximum permissible absolute pressure at the inlet orifice. The paper gives experimental characteristics of the fluid flow process through the nozzle for different values of internal diameter of a straight case and an extent of its end face remoteness from an external wall of the inlet orifice. It estimates how geometry of nozzle constructive elements influences on the volume flow rate. It is established that the nozzle capacity significantly depends on the shape of inlet orifice. Triangular orifice nozzles steadily work in the mode of completely filled flow area of the straight case at much more amounts of the limit pressure of the flow. Vacuum depth in the evacuated chamber also depends on the shape of inlet orifice: the greatest vacuum is reached in a nozzle with the triangular orifice which 1.5 times exceeds the greatest vacuum with the round orifice. Possibility to control nozzle capacity through the regulated connection of the evacuated chamber to the atmosphere was experimentally estimated, thus depth of flow rate regulation of the nozzle with a triangular orifice was 45% in comparison with 10% regulation depth of the nozzle with a round orifice. Depth of regulation calculated by a mathematical model appeared to be much more. The paper presents experimental dependences of the flow coefficients of nozzle input orifice

  1. Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Tae Hoon; Chennakrishnaiah, Shilpa [Montreal Children’s Hospital, Research Institute of McGill University Health Centre, McGill University, Montreal, Quebec (Canada); Audemard, Eric [McGill University and Genome Quebec Innovation Centre, Montreal, Quebec (Canada); Montermini, Laura; Meehan, Brian [Montreal Children’s Hospital, Research Institute of McGill University Health Centre, McGill University, Montreal, Quebec (Canada); Rak, Janusz, E-mail: janusz.rak@mcgill.ca [Montreal Children’s Hospital, Research Institute of McGill University Health Centre, McGill University, Montreal, Quebec (Canada)

    2014-08-22

    Highlights: • Oncogenic H-ras stimulates emission of extracellular vesicles containing double-stranded DNA. • Vesicle-associated extracellular DNA contains mutant N-ras sequences. • Vesicles mediate intercellular transfer of mutant H-ras DNA to normal fibroblasts where it remains for several weeks. • Fibroblasts exposed to vesicles containing H-ras DNA exhibit increased proliferation. - Abstract: Cell free DNA is often regarded as a source of genetic cancer biomarkers, but the related mechanisms of DNA release, composition and biological activity remain unclear. Here we show that rat epithelial cell transformation by the human H-ras oncogene leads to an increase in production of small, exosomal-like extracellular vesicles by viable cancer cells. These EVs contain chromatin-associated double-stranded DNA fragments covering the entire host genome, including full-length H-ras. Oncogenic N-ras and SV40LT sequences were also found in EVs emitted from spontaneous mouse brain tumor cells. Disruption of acidic sphingomyelinase and the p53/Rb pathway did not block emission of EV-related oncogenic DNA. Exposure of non-transformed RAT-1 cells to EVs containing mutant H-ras DNA led to the uptake and retention of this material for an extended (30 days) but transient period of time, and stimulated cell proliferation. Thus, our study suggests that H-ras-mediated transformation stimulates vesicular emission of this histone-bound oncogene, which may interact with non-transformed cells.

  2. Improved Analysis Techniques for Cylindrical and Spherical Double Probes (Preprint)

    Science.gov (United States)

    2012-03-21

    accounts for the finite, but non -negligible extent of the plasma sheath. One of the most extensive assessments of ion collection by a biased cylindrical...Approved for public release; distribution unlimited. 4 regardless of rP/λD so long as the electron distribution function is Maxwellian such that...731. 3 J.G. Laframboise, Theory of Spherical and Cylindrical Langmuir Probes in a Collisionless, Maxwellian Plasma at Rest, (University of Toronto

  3. An Approximate Solution for Spherical and Cylindrical Piston Problem

    Indian Academy of Sciences (India)

    S K Singh; V P Singh

    2000-02-01

    A new theory of shock dynamics (NTSD) has been derived in the form of a finite number of compatibility conditions along shock rays. It has been used to study the growth and decay of shock strengths for spherical and cylindrical pistons starting from a non-zero velocity. Further a weak shock theory has been derived using a simple perturbation method which admits an exact solution and also agrees with the classical decay laws for weak spherical and cylindrical shocks.

  4. On elliptic cylindrical Kadomtsev-Petviashvili equation for surface waves

    CERN Document Server

    Khusnutdinova, K R; Matveev, V B; Smirnov, A O

    2012-01-01

    The `elliptic cylindrical Kadomtsev-Petviashvili equation' is derived for surface gravity waves with nearly-elliptic front, generalising the cylindrical KP equation for nearly-concentric waves. We discuss transformations between the derived equation and two existing versions of the KP equation, for nearly-plane and nearly-concentric waves. The transformations are used to construct important classes of exact solutions of the derived equation and corresponding approximate solutions for surface waves.

  5. Cylindrical bubbles and blobs from a Class II Hydrophobin

    Science.gov (United States)

    Russo, Paul; Pham, Michael; Blalock, Brad

    2012-02-01

    Cerato ulmin is a class II hydrophobin. In aqueous suspensions, it easily forms cylindrical air bubbles and cylindrical oil blobs. The conditions for formation of these unusual structures will be discussed, along with scattering and microscopic investigations of their remarkable stability. Possible applications in diverse fields including polymer synthesis and oil spill remediation will be considered. Acknowledgment is made to Dr. Wayne C. Richards of the Canadian Forest Service for the gift of Cerato ulmin.

  6. Scattering of electromagnetic waves by an non-uniform cylindrical plasma; Diffusion coherente d'une onde electromagnetique par un cylindre de plasma inhomogene

    Energy Technology Data Exchange (ETDEWEB)

    Faugeras, P.E. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires. Groupe de recherches sur la fusion controlee

    1967-07-01

    The problem of the scattering of plane electromagnetic waves from a non-uniform, cylindrically symmetrical plasma is solved analytically, by a self-consistent field method, for a wave with the electric field parallel to the cylinder axis. Numerical results for the diffracted field are plotted for interesting ranges of the parameters involved: diameter, density on the axis, radial profile of the density, and collision frequencies. The case where the incident field is cylindric (waves surfaces parallel to the cylinder axis) is examined - this permits to connect theoretical calculations and experimental diffraction patterns, and also to explain the diffraction effects observed in a classical microwave interferometry experiment. These results, and the possibility of measuring exactly the diffracted field (showed by experiments with dielectric and metallic rods) lead to a new plasma diagnostic method, based on the diffraction, which has no theoretical limitations and it usable when the classical free-space wave methods are not (plasma diameter lower than 10 wave lengths). The feasibility of this method is tested with a plasma at atmospheric pressure and a 2 mm incident wavelength. The plasma is obtained by the laminar flow of a plasma torch, with a working gas (He or Ar) seeded by potassium (density continuously variable between 10{sup 11} and 10{sup 15} e/cm{sup 3}. Some diffraction patterns by this plasma and for various incident waves, are also given and explained with theoretical calculations. (author) [French] On etudie la diffusion coherente d'une onde electromagnetique par un cylindre de plasma inhomogene par une methode de champ self-consistant, et pour une onde de vecteur electrique parallele a l'axe du cylindre. On a calcule le champ diffracte en faisant varier le diametre du cylindre, la densite sur l'axe, le profil de densite et les frequences de collisions, et on donne ici les principaux resultats. On examine ensuite le cas d'une onde

  7. Analysis and Modeling of Curing Polyester Resin in Cylindrical Moulds Heated by Air

    Directory of Open Access Journals (Sweden)

    Gomzi, Z.

    2009-09-01

    Full Text Available The mathematical model of the cure of unsaturated polyester resin in cylindrical mould heated with warm air was suggested and derived. The model assumes convective heat transfer through air on the wall of the mould and conductive heat transfer through the resin. The temperature within the sample changes during the cure process, which is the result of the reaction being exothermal and the process of heat transfer. The addition of the filler changes the thermal properties of the mixture and reduces the amount of heat generated during the reaction in the sample of the same volume, which leads to lower temperature maximums in the center of the cylindrical mould. The model was tested with multiple experiments in which the temperature of the resin inside the mould during the cure process was measured. The heat transfer coefficients between the air and wall of the mould with different speeds of air flow were estimated using independent experiments where the glycerol was used instead of resin. Estimated values were compared with known correlations and good agreement was obtained. Using the suggested model, the cure process in the cylindrical mould can be simulated accurately and influents of the heat transfer and reaction rate on the temperature maximums can be studied.

  8. Magnetic field effects on the electron Raman scattering in coaxial cylindrical quantum well wires

    Energy Technology Data Exchange (ETDEWEB)

    Rezaei, G., E-mail: grezaei2001@gmail.com [Department of Physics, College of Sciences, Yasouj University, Yasouj 75914-353 (Iran, Islamic Republic of); Karimi, M.J.; Pakarzadeh, H. [Department of Physics, College of Sciences, Shiraz University of Technology, Shiraz 71555-313 (Iran, Islamic Republic of)

    2013-11-15

    Based on the effective mass and parabolic one band approximations, the influence of an external magnetic field on the differential cross-section for the intersubband electron Raman scattering process in coaxial cylindrical quantum well wires is investigated. The dependence of differential cross-section on magnetic field strength and structural parameters of the coaxial cylindrical quantum well wire is studied. It is found that the magnetic field strength and the geometrical size of the system have a great influence on the position of the singularities in the emission spectra. Moreover, one can control the frequency shift in the Raman spectrum by varying the magnetic field strength and the size of the coaxial cylindrical quantum well wire. -- Highlights: • Magnetic field effects on ERS in CCQWWs are investigated. • Light polarization vectors and geometrical size effects on the ERS are also studied. • Number, position and magnitude of the peaks depend on the magnetic field strength. • The light polarization vectors have a great influence on the magnitude of the peaks. • An increase in the size leads to the considerable changes in the emission spectra.

  9. Packing and deploying Soft Origami to and from cylindrical volumes with application to automotive airbags.

    Science.gov (United States)

    Bruton, Jared T; Nelson, Todd G; Zimmerman, Trent K; Fernelius, Janette D; Magleby, Spencer P; Howell, Larry L

    2016-09-01

    Packing soft-sheet materials of approximately zero bending stiffness using Soft Origami (origami patterns applied to soft-sheet materials) into cylindrical volumes and their deployment via mechanisms or internal pressure (inflation) is of interest in fields including automobile airbags, deployable heart stents, inflatable space habitats, and dirigible and parachute packing. This paper explores twofold patterns, the 'flasher' and the 'inverted-cone fold', for packing soft-sheet materials into cylindrical volumes. Two initial packing methods and mechanisms are examined for each of the flasher and inverted-cone fold patterns. An application to driver's side automobile airbags is performed, and deployment tests are completed to compare the influence of packing method and origami pattern on deployment performance. Following deployment tests, two additional packing methods for the inverted-cone fold pattern are explored and applied to automobile airbags. It is shown that modifying the packing method (using different methods to impose the same base pattern on the soft-sheet material) can lead to different deployment performance. In total, two origami patterns and six packing methods are examined, and the benefits of using Soft Origami patterns and packing methods are discussed. Soft Origami is presented as a viable method for efficiently packing soft-sheet materials into cylindrical volumes.

  10. Packing and deploying Soft Origami to and from cylindrical volumes with application to automotive airbags

    Science.gov (United States)

    Bruton, Jared T.; Nelson, Todd G.; Zimmerman, Trent K.; Fernelius, Janette D.; Magleby, Spencer P.; Howell, Larry L.

    2016-09-01

    Packing soft-sheet materials of approximately zero bending stiffness using Soft Origami (origami patterns applied to soft-sheet materials) into cylindrical volumes and their deployment via mechanisms or internal pressure (inflation) is of interest in fields including automobile airbags, deployable heart stents, inflatable space habitats, and dirigible and parachute packing. This paper explores twofold patterns, the `flasher' and the `inverted-cone fold', for packing soft-sheet materials into cylindrical volumes. Two initial packing methods and mechanisms are examined for each of the flasher and inverted-cone fold patterns. An application to driver's side automobile airbags is performed, and deployment tests are completed to compare the influence of packing method and origami pattern on deployment performance. Following deployment tests, two additional packing methods for the inverted-cone fold pattern are explored and applied to automobile airbags. It is shown that modifying the packing method (using different methods to impose the same base pattern on the soft-sheet material) can lead to different deployment performance. In total, two origami patterns and six packing methods are examined, and the benefits of using Soft Origami patterns and packing methods are discussed. Soft Origami is presented as a viable method for efficiently packing soft-sheet materials into cylindrical volumes.

  11. Lead Poisoning

    Science.gov (United States)

    ... lead is of microscopic size, invisible to the naked eye. More often than not, children with elevated ... majority of the childhood lead poisoning cases we see today. Children and adults too can get seriously ...

  12. Theory and modeling of cylindrical thermo-acoustic transduction

    Energy Technology Data Exchange (ETDEWEB)

    Tong, Lihong, E-mail: lhtong@ecjtu.edu.cn [School of Civil Engineering and Architecture, East China Jiaotong University, Nanchang, Jiangxi (China); Lim, C.W. [Department of Architecture and Civil Engineering, City University of Hong Kong, Kowloon, Hong Kong SAR (China); Zhao, Xiushao; Geng, Daxing [School of Civil Engineering and Architecture, East China Jiaotong University, Nanchang, Jiangxi (China)

    2016-06-03

    Models both for solid and thinfilm-solid cylindrical thermo-acoustic transductions are proposed and the corresponding acoustic pressure solutions are obtained. The acoustic pressure for an individual carbon nanotube (CNT) as a function of input power is investigated analytically and it is verified by comparing with the published experimental data. Further numerical analysis on the acoustic pressure response and characteristics for varying input frequency and distance are also examined both for solid and thinfilm-solid cylindrical thermo-acoustic transductions. Through detailed theoretical and numerical studies on the acoustic pressure solution for thinfilm-solid cylindrical transduction, it is concluded that a solid with smaller thermal conductivity favors to improve the acoustic performance. In general, the proposed models are applicable to a variety of cylindrical thermo-acoustic devices performing in different gaseous media. - Highlights: • Theory and modeling both for solid and thinfilm-solid cylindrical thermo-acoustic transductions are proposed. • The modeling is verified by comparing with the published experimental data. • Acoustic response characteristics of cylindrical thermo-acoustic transductions are predicted by the proposed model.

  13. Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis.

    Science.gov (United States)

    Sethi, Gautam; Ahn, Kwang Seok; Sung, Bokyung; Aggarwal, Bharat B

    2008-06-01

    Pinitol (3-O-methyl-chiroinositol), a component of traditional Ayurvedic medicine (talisapatra), has been shown to exhibit anti-inflammatory and antidiabetic activities through undefined mechanisms. Because the transcription factor nuclear factor-kappaB (NF-kappaB) has been linked with inflammatory diseases, including insulin resistance, we hypothesized that pinitol must mediate its effects through modulation of NF-kappaB activation pathway. We found that pinitol suppressed NF-kappaB activation induced by inflammatory stimuli and carcinogens. This suppression was not specific to cell type. Besides inducible, pinitol also abrogated constitutive NF-kappaB activation noted in most tumor cells. The suppression of NF-kappaB activation by pinitol occurred through inhibition of the activation of IkappaBalpha kinase, leading to sequential suppression of IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation, p65 nuclear translocation, and NF-kappaB-dependent reporter gene expression. Pinitol also suppressed the NF-kappaB reporter activity induced by tumor necrosis factor receptor (TNFR)-1, TNFR-associated death domain, TNFR-associated factor-2, transforming growth factor-beta-activated kinase-1 (TAK-1)/TAK1-binding protein-1, and IkappaBalpha kinase but not that induced by p65. The inhibition of NF-kappaB activation thereby led to down-regulation of gene products involved in inflammation (cyclooxygenase-2), proliferation (cyclin D1 and c-myc), invasion (matrix metalloproteinase-9), angiogenesis (vascular endothelial growth factor), and cell survival (cIAP1, cIAP2, X-linked inhibitor apoptosis protein, Bcl-2, and Bcl-xL). Suppression of these gene products by pinitol enhanced the apoptosis induced by TNF and chemotherapeutic agents and suppressed TNF-induced cellular invasion. Our results show that pinitol inhibits the NF-kappaB activation pathway, which may explain its ability to suppress inflammatory cellular responses.

  14. Relational Leading

    DEFF Research Database (Denmark)

    2015-01-01

    This first chapter presents the exploratory and curious approach to leading as relational processes – an approach that pervades the entire book. We explore leading from a perspective that emphasises the unpredictable challenges and triviality of everyday life, which we consider an interesting......, relevant and realistic way to examine leading. The chapter brings up a number of concepts and contexts as formulated by researchers within the field, and in this way seeks to construct a first understanding of relational leading....

  15. Stable pseudoanalytical computation of electromagnetic fields from arbitrarily-oriented dipoles in cylindrically stratified media

    Science.gov (United States)

    Moon, Haksu; Teixeira, Fernando L.; Donderici, Burkay

    2014-09-01

    Computation of electromagnetic fields due to point sources (Hertzian dipoles) in cylindrically stratified media is a classical problem for which analytical expressions of the associated tensor Green's function have been long known. However, under finite-precision arithmetic, direct numerical computations based on the application of such analytical (canonical) expressions invariably lead to underflow and overflow problems related to the poor scaling of the eigenfunctions (cylindrical Bessel and Hankel functions) for extreme arguments and/or high-order, as well as convergence problems related to the numerical integration over the spectral wavenumber and to the truncation of the infinite series over the azimuth mode number. These problems are exacerbated when a disparate range of values is to be considered for the layers' thicknesses and material properties (resistivities, permittivities, and permeabilities), the transverse and longitudinal distances between source and observation points, as well as the source frequency. To overcome these challenges in a systematic fashion, we introduce herein different sets of range-conditioned, modified cylindrical functions (in lieu of standard cylindrical eigenfunctions), each associated with nonoverlapped subdomains of (numerical) evaluation to allow for stable computations under any range of physical parameters. In addition, adaptively-chosen integration contours are employed in the complex spectral wavenumber plane to ensure convergent numerical integration in all cases. We illustrate the application of the algorithm to problems of geophysical interest involving layer resistivities ranging from 1000 Ω m to 10-8 Ω m, frequencies of operation ranging from 10 MHz down to the low magnetotelluric range of 0.01 Hz, and for various combinations of layer thicknesses.

  16. Growth of buckling instabilities during radial collapse of an impulsively-loaded cylindrical shell

    Energy Technology Data Exchange (ETDEWEB)

    Duffey, T.A.; Warnes, R.H.; Greene, J.M.

    1987-01-01

    Conditions leading to the growth of initial imperfections for rings or cylindrical shells subjected to initial uniform inward impulsive velocity loading are investigated. The work is motivated by a need to prevent buckling of rings during the contracting ring test, which is used to determine intermediate strain rate compressive stress-strain data. A previous analysis by Abrahamson is extended to include deceleration of the ring during inward motion; and the results of this deceleration are found to greatly influence the growth of imperfections (buckling). Qualitative comparisons with experimental data are presented.

  17. Buckling analysis of stringer-stiffened laminated cylindrical shells with nonuniform eccentricity

    Energy Technology Data Exchange (ETDEWEB)

    Sadeghifar, M. [Islamic Azad University, Department of Mechanical Engineering, Nowshahr Branch, Nowshahr (Iran, Islamic Republic of); Bagheri, M. [Sattari Air University, Faculty of Aerospace Engineering, Tehran (Iran, Islamic Republic of); Jafari, A.A. [K.N. Toosi University of Technology, Faculty of Mechanical Engineering, Tehran (Iran, Islamic Republic of)

    2011-07-15

    In this study, the influence of nonuniformity of eccentricity of stringers on the general axial buckling load of stiffened laminated cylindrical shells with simply supported end conditions is investigated. The critical loads are calculated using Love's First-order Shear Deformation Theory and solved using the Rayleigh-Ritz procedure. The effects of the shell length-to-radius ratio, shell thickness-to-radius ratio, number of stringers, and stringers depth-to-width ratio on the buckling load of nonuniformly eccentric shells, are examined. The research demonstrates that an appropriate nonuniform distribution of eccentricity of stringers leads the buckling load to increase significantly. (orig.)

  18. Fracture of cylindrical ampoules during solid phase synthesis under explosive loading

    Science.gov (United States)

    Zelepugin, S. A.; Ivanova, O. V.; Yunoshev, A. S.; Zelepugin, A. S.

    2017-02-01

    The paper presents the numerical and experimental study of the behavior of porous reactive mixtures (Al-S and Al-Tf) under explosive loading using a multicomponent medium model. The initial dispersion of the reactive mixture is varied to evaluate its contribution to the fracture of the cylindrical ampoule. The results have shown that the high rate of heat release during the chemical reaction in the bottom part of the ampoule and a sharp increase in pressure lead to the formation of the gas phase, which causes the ampoule fracture. It is found that the higher the initial dispersion of the mixture components is, the more intensive the ampoule failure is.

  19. 现代圆柱滚子轴承设计%Design of Modem Cylindrical Roller Bearing

    Institute of Scientific and Technical Information of China (English)

    张俊杰; 潘德仁; 王敏

    2000-01-01

    By improving steel material quality,adopting plastic cage,improving rib structure and using crowned rollers,the life and performance of cylindrical roller bearing can be largely increased.The paper introduces the establishment of target function,determination of restrict condition and optimizing design for some parameters such as roller diameter,length,number of roller and the maximum dynamic load rating etc,and emphasizes on statement for crowned desip of roller and selection of cage.

  20. A miniaturised, nested-cylindrical electrostatic analyser geometry for dual electron and ion, multi-energy measurements

    Energy Technology Data Exchange (ETDEWEB)

    Bedington, Robert, E-mail: r.bedington@nus.edu.sg; Kataria, Dhiren; Smith, Alan

    2015-09-01

    The CATS (Cylindrical And Tiny Spectrometer) electrostatic optics geometry features multiple nested cylindrical analysers to simultaneously measure multiple energies of electron and multiple energies of ion in a configuration that is targeted at miniaturisation and MEMS fabrication. In the prototyped model, two configurations of cylindrical analyser were used, featuring terminating side-plates that caused particle trajectories to either converge (C type) or diverge (D type) in the axial direction. Simulations show how these different electrode configurations affect the particle focussing and instrument parameters; C-type providing greater throughputs but D-type providing higher resolving powers. The simulations were additionally used to investigate unexpected plate spacing variations in the as-built model, revealing that the k-factors are most sensitive to the width of the inter-electrode spacing at its narrowest point. - Highlights: • A new nested cylindrical miniaturised electrostatic analyser geometry is described. • “Converging” (C) and “diverging” (D) type channel properties are investigated. • C channels are shown to have greater throughputs and D greater resolving powers. • Plate factors are shown to be sensitive to the minimum in inter-electrode spacing.

  1. Lead Test

    Science.gov (United States)

    ... months, and at 3, 4, 5, and 6 years of age. A blood lead level test should be done only if the risk ... recommended if the person is symptomatic at any level below 70 mcg/dL. Because lead will pass through the blood to an unborn child, pregnant ...

  2. Novel spherical hohlraum with cylindrical laser entrance holes and shields

    Energy Technology Data Exchange (ETDEWEB)

    Lan, Ke [Institute of Applied Physics and Computational Mathematics, Beijing 100088 (China); Center for Applied Physics and Technology, Peking University, Beijing 100871 (China); Zheng, Wudi [Institute of Applied Physics and Computational Mathematics, Beijing 100088 (China)

    2014-09-15

    Our recent works [K. Lan et al., Phys. Plasmas 21, 010704 (2014); K. Lan et al., Phys. Plasmas 21, 052704 (2014)] have shown that the octahedral spherical hohlraums are superior to the cylindrical hohlraums in both higher symmetry during the capsule implosion and lower backscatter without supplementary technology. However, both the coupling efficiency from the drive laser energy to the capsule and the capsule symmetry decrease remarkably when larger laser entrance holes (LEHs) are used. In addition, the laser beams injected at angles > 45° transport close to the hohlraum wall, thus the wall blowoff causes the LEH to close faster and results in strong laser plasma interactions inside the spherical hohlraums. In this letter, we propose a novel octahedral hohlraum with LEH shields and cylindrical LEHs to alleviate these problems. From our theoretical study, with the LEH shields, the laser coupling efficiency is significantly increased and the capsule symmetry is remarkably improved in the spherical hohlraums. The cylindrical LEHs take advantage of the cylindrical hohlraum near the LEH and mitigate the influence of the blowoff on laser transport inside a spherical hohlraum. The cylindrical LEHs can also be applied to the rugby and elliptical hohlraums.

  3. Peltier Current Leads with conical configuration

    Science.gov (United States)

    Hakimi, I.; Nikulshin, Y.; Wolfus, S.; Yeshurun, Y.

    2016-04-01

    Current leads in cryogenic systems are a major heat source which eventually affects the entire system. It has been shown in recent years that Peltier elements are useful in reducing incoming heat into the cold system. In this article we present a new tapered cone-like configuration of the Peltier Current Leads which increases the power saving. This configuration is compared to the standard cylindrical configuration utilizing advanced ANSYS simulations. The simulations show an additional power saving of 4% when using the tapered lead configuration.

  4. Determination of the Boltzmann Constant Using the Differential - Cylindrical Procedure

    CERN Document Server

    Feng, X J; Lin, H; Gillis, K A; Moldover, M R

    2015-01-01

    We report in this paper the progresses on the determination of the Boltzmann constant using the acoustic gas thermometer (AGT) of fixed-length cylindrical cavities. First, we present the comparison of the molar masses of pure argon gases through comparing speeds of sound of gases. The procedure is independent from the methodology by Gas Chromatography-Mass Spectrometry (GC-MS). The experimental results show good agreement between both methods. The comparison offers an independent inspection of the analytical results by GC-MS. Second, we present the principle of the novel differential-cylindrical procedure based on the AGT of two fixed-length cavities. The deletion mechanism for some major perturbations is analyzed for the new procedure. The experimental results of the differential-cylindrical procedure demonstrate some major improvements on the first, second acoustic and third virial coefficients, and the excess half-widths. The three acoustic virial coefficients agree well with the stated-of-the-art experime...

  5. Experiments of cylindrical isentropic compression by ultrahigh magnetic field

    Directory of Open Access Journals (Sweden)

    Gu Zhuowei

    2015-01-01

    Full Text Available The high Explosive Magnetic Flux Implosion Compression Generator (EMFICG is a kind of unique high energy density dynamic technique with characters like ultrahigh pressure and low temperature rising and could be suitable as a tool of cylindrical isentropic compression. The Institute of Fluid Physics, Chinese Academy of Engineering Physics (IFP, CAEP have developed EMFICG technique and realized cylindrical isentropic compression. In the experiments, a seed magnetic field of 5–6 Tesla were built first and compressed by a stainless steel liner which is driven by high explosive. The inner free surface velocity of sample was measured by PDV. The isentropic compression of a copper sample was verified and the isentropic pressure is over 100 GPa. The cylindrical isentropic compression process has been numerical simulated by 1D MHD code and the simulation results were compared with the experiments. Compared with the transitional X-ray flash radiograph measurement, this method will probably promote the data accuracy.

  6. Encoding high-order cylindrically polarized light beams.

    Science.gov (United States)

    Moreno, Ignacio; Davis, Jeffrey A; Cottrell, Don M; Donoso, Ramiro

    2014-08-20

    In this work we present a setup for the experimental production of cylindrically polarized beams, as well as other variations of polarized light beams. The optical system uses a single transmissive phase-only spatial light modulator, which is used to apply different spatial phase modulation to two output collinear R and L circularly polarized components. Different cylindrically polarized light beams can be obtained by applying different phase shifts to these two circularly polarized components. The system is very efficient since modulation is directly applied to the light beam (as opposed to other common methods operating in the first order of encoded diffraction gratings). Different variations to the cylindrically polarized light beams are also reported, obtained by adding linear or quadratic relative phase shifts between the two circular polarization components of the light beam. Experimental results are provided in all cases.

  7. A cylindrical converging shock tube for shock-interface studies.

    Science.gov (United States)

    Luo, Xisheng; Si, Ting; Yang, Jiming; Zhai, Zhigang

    2014-01-01

    A shock tube facility for generating a cylindrical converging shock wave is developed in this work. Based on the shock dynamics theory, a specific wall profile is designed for the test section of the shock tube to transfer a planar shock into a cylindrical one. The shock front in the converging part obtained from experiment presents a perfect circular shape, which proves the feasibility and reliability of the method. The time variations of the shock strength obtained from numerical simulation, experiment, and theoretical estimation show the desired converging effect in the shock tube test section. Particular emphasis is then placed on the problem of shock-interface interaction induced by cylindrical converging shock waves. For this purpose, membrane-less gas cylinder is adopted to form the interface between two different fluids while the laser sheet technique to visualize the flow field. The result shows that it is convenient to perform such experiments in this facility.

  8. POSTBUCKLING OF PRESSURE-LOADED SHEAR DEFORMABLE LAMINATED CYLINDRICAL PANELS

    Institute of Scientific and Technical Information of China (English)

    沈惠申

    2003-01-01

    A postbuckling analysis is presented for a shear deformable laminated cylindrical panel of finite length subjected to lateral pressure. The governing equations are based on Reddy's higher order shear deformation shell theory with yon Kdrmdn-Donnell-type of kinematic nonlinearity. The nonlinear prebuckling deformations and initial geometric imperfections of the panel are both taken into account. A boundary layer theory of shell buckling, which includes the effects of nonlinear prebuckling deformations, large deflections in the postbuckling range, and initial geometric imperfections of the shell, is extended to the case of shear deformable laminated cylindrical panels under lateral pressure. A singular perturbation technique is employed to determine the buckling loads and postbuckling equilibrium paths. The numerical illustrations concern the postbuckling response of perfect and imperfect, moderately thick, cross-ply laminated cylindrical panels. The effects played by transverse shear deformation, panel geometric parameters, total number of plies, fiber orientation, and initial geometric imperfections are studied.

  9. Design of elliptic cylindrical thermal cloak with layered structure

    Science.gov (United States)

    Yuan, Xuebo; Lin, Guochang; Wang, Youshan

    2017-01-01

    Thermal cloak has potential applications in thermal protection and sensing. Based on the theories of spatial transformation and effective medium, layered structure of elliptic cylindrical thermal cloak was designed. According to theoretical analysis and numerical simulation, the layered structure has typical characteristics of perfect thermal cloak. The external temperature field remains unchanged, while the internal temperature gradient decreases obviously. Meanwhile, the cloaking effect is stable in any direction. The cloaking effect can be improved by increasing the number of discretization layers or reducing the cloak thickness. The elliptic cylindrical cloak can be considered as cylindrical cloak when the focal distance is close to zero. This study has provided an effective way for realizing thermal cloak with more complex shapes.

  10. Third-generation cylindrical diffusers for medical use

    Science.gov (United States)

    Lytle, A. Charles; Narciso, Hugh L.; Spain, David V.; Doiron, Daniel R.

    1993-05-01

    Cylindrical light diffusion is a key element in a variety of medical applications which require the controlled administration of light to a treatment site within the body. Applications such as photodynamic therapy (PDT), laser induced hyperthermia (LHT), and photoatherolytic (PAL) therapy may all require that light be diffused in this manner. Cylindrical diffusers are typically used in tubular cavities, such as the bronchus, trachea, or the esophagus, and in interstitial applications where uniform illumination over a specified length is required to maximize the therapeutic response. A third generation of cylindrical diffuser with improved performance has been developed to more effectively meet these needs. This paper will discuss the evolution of cylinder diffusers and will describe the characteristics and performance of this new generation device.

  11. Radiation and scattering from printed antennas on cylindrically conformal platforms

    Science.gov (United States)

    Kempel, Leo C.; Volakis, John L.; Bindiganavale, Sunil

    1994-01-01

    The goal was to develop suitable methods and software for the analysis of antennas on cylindrical coated and uncoated platforms. Specifically, the finite element boundary integral and finite element ABC methods were employed successfully and associated software were developed for the analysis and design of wraparound and discrete cavity-backed arrays situated on cylindrical platforms. This work led to the successful implementation of analysis software for such antennas. Developments which played a role in this respect are the efficient implementation of the 3D Green's function for a metallic cylinder, the incorporation of the fast Fourier transform in computing the matrix-vector products executed in the solver of the finite element-boundary integral system, and the development of a new absorbing boundary condition for terminating the finite element mesh on cylindrical surfaces.

  12. Numerical investigation on evolution of cylindrical cellular detonation

    Institute of Scientific and Technical Information of China (English)

    WANG Chun; JIANG Zong-lin; HU Zong-min; HAN Gui-lai

    2008-01-01

    Cylindrical cellular detonation is numerically investigated by solving twodimensional reactive Euler equations with a finite volume method on a two-dimensional self-adaptive unstructured mesh.The one-step reversible chemical reaction model is applied to simplify the control parameters of chemical reaction.Numerical results demonstrate the evolution of cellular cell splitting of cylindrical cellular detonation explored in experimentas.Split of cellular structures shows different features in the near-field and far-field from the initiation zone.Variation of the local curvature is a key factor in the behavior of cell split of cylindrical cellular detonation in propagation.Numerical results show that split of cellular structures comes from the self-organization of transverse waves corresponding to the development of small disturbances along the detonation front related to detonation instability.

  13. Lead Poisoning

    Science.gov (United States)

    ... Topics Environment & Health Healthy Living Pollution Reduce, Reuse, Recycle Science – How It Works The Natural World Games ... OTHERS: Lead has recently been found in some plastic mini-blinds and vertical blinds which were made ...

  14. The magnetic properties of the hollow cylindrical ideal remanence magnet

    DEFF Research Database (Denmark)

    Bjørk, Rasmus

    2016-01-01

    We consider the magnetic properties of the hollow cylindrical ideal remanence magnet. This magnet is the cylindrical permanent magnet that generates a uniform field in the cylinder bore, using the least amount of magnetic energy to do so. The remanence distribution of this magnet is derived...... and the generated field is compared to that of a Halbach cylinder of equal dimensions. The ideal remanence magnet is shown in most cases to generate a significantly lower field than the equivalent Halbach cylinder, although the field is generated with higher efficiency. The most efficient Halbach cylinder is shown...... to generate a field exactly twice as large as the equivalent ideal remanence magnet....

  15. Transient impact responses of laminated composite cylindrical shells

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The generalized ray method(GRM) has been successfully used to study the transient elastic wave transmitting in the beams,planar trusses,space frames and infinite layered media.In this letter,the GRM is extended to investigate the early short time transient responses of laminated composite cylindrical shells under impact load.By using the Laplace transformation and referring to the boundary conditions,the ray groups transmitting in the finite laminated cylindrical shells under the shock load are obtained ...

  16. Static Cylindrically Symmetric Interior Solutions in f(R) Gravity

    CERN Document Server

    Sharif, M

    2013-01-01

    We investigate some exact static cylindrically symmetric solutions for a perfect fluid in the metric $f(R)$ theory of gravity. For this purpose, three different families of solutions are explored. We evaluate energy density, pressure, Ricci scalar and functional form of $f(R)$. It is interesting to mention here that two new exact solutions are found from the last approach, one is in particular form and the other is in the general form. The general form gives a complete description of a cylindrical star in $f(R)$ gravity.

  17. Analytic descriptions of cylindrical electromagnetic waves in a nonlinear medium.

    Science.gov (United States)

    Xiong, Hao; Si, Liu-Gang; Yang, Xiaoxue; Wu, Ying

    2015-06-15

    A simple but highly efficient approach for dealing with the problem of cylindrical electromagnetic waves propagation in a nonlinear medium is proposed based on an exact solution proposed recently. We derive an analytical explicit formula, which exhibiting rich interesting nonlinear effects, to describe the propagation of any amount of cylindrical electromagnetic waves in a nonlinear medium. The results obtained by using the present method are accurately concordant with the results of using traditional coupled-wave equations. As an example of application, we discuss how a third wave affects the sum- and difference-frequency generation of two waves propagation in the nonlinear medium.

  18. Ideal cylindrical cloak: perfect but sensitive to tiny perturbations.

    Science.gov (United States)

    Ruan, Zhichao; Yan, Min; Neff, Curtis W; Qiu, Min

    2007-09-14

    A cylindrical wave expansion method is developed to obtain the scattering field for an ideal two-dimensional cylindrical invisibility cloak. A near-ideal model of the invisibility cloak is set up to solve the boundary problem at the inner boundary of the cloak shell. We confirm that a cloak with the ideal material parameters is a perfect invisibility cloak by systematically studying the change of the scattering coefficients from the near-ideal case to the ideal one. However, because of the slow convergence of the zeroth-order scattering coefficients, a tiny perturbation on the cloak would induce a noticeable field scattering and penetration.

  19. Confined and interface phonons in combined cylindrical nanoheterosystem

    Directory of Open Access Journals (Sweden)

    O.M.Makhanets

    2006-01-01

    Full Text Available The spectra of all types of phonons existing in a complicated combined nanoheterosystem consisting of three cylindrical quantum dots embedded into the cylindrical quantum wire placed into vacuum are studied within the dielectric continuum model. It is shown that there are confined optical (LO and interface phonons of two types: top surface optical (TSO and side surface optical (SSO modes of vibration in such a nanosystem. The dependences of phonon energies on the quasiwave numbers and geometrical parameters of quantum dots are investigated and analysed.

  20. Friction Compensation in the Upsetting of Cylindrical Test Specimens

    DEFF Research Database (Denmark)

    Christiansen, Peter; Martins, P. A. F.; Bay, Niels Oluf

    2016-01-01

    This manuscript presents a combined numerical andexperimental methodology for determining the stress-straincurve of metallic materials from the measurements of forceand displacement obtained in the axial compression of cylindrical test specimens with friction between the specimens and the platens...... model or combined friction models are utilized .Experimental results obtained from cylindrical and Rastegaev test specimens with different lubricants combined with the experimental determination of friction by means of ring compression tests allows compensating the effect of friction...... Appendix is provided for those readers interested in utilizing the associated numerical algorithm for determining the stress straincurves of metallic materials....

  1. The magnetic properties of the hollow cylindrical ideal remanence magnet

    CERN Document Server

    Bjørk, R

    2016-01-01

    We consider the magnetic properties of the hollow cylindrical ideal remanence magnet. This magnet is the cylindrical permanent magnet that generates a uniform field in the cylinder bore, using the least amount of magnetic energy to do so. The remanence distribution of this magnet is derived and the generated field is compared to that of a Halbach cylinder of equal dimensions. The ideal remanence magnet is shown in most cases to generate a significantly lower field than the equivalent Halbach cylinder, although the field is generated with higher efficiency. The most efficient Halbach cylinder is shown to generate a field exactly twice as large as the equivalent ideal remanence magnet.

  2. Liquid bridge as a tunable-focus cylindrical liquid lens

    Science.gov (United States)

    Chen, H.; Tabatabaei, N.; Amirfazli, A.

    2017-01-01

    We proposed a method to create a tunable-focus cylindrical liquid lens using a liquid bridge between two narrow surfaces. Due to the surface edge effect, the interface of the liquid bridge (on the long side) was shown to be able to serve as a tunable-focus cylindrical liquid lens. The working distance of the lens can be adjusted by changing either or both of the height of the bridge (H) and the volume of the liquid (V). By varying H and V, the lens can serve as either diverging or converging lens, with a minimum working distance of 2.11 mm.

  3. Simple model of capillary condensation in cylindrical pores

    Science.gov (United States)

    Szybisz, Leszek; Urrutia, Ignacio

    2002-11-01

    A simple model based on an approximation of the dropletlike model is formulated for studying adsorption of fluids into cylindrical pores. This model yields a nearly universal description of capillary condensation transitions for noble gases confined by alkali metals. The system's thermodynamical behavior is predicted from the values of two dimensionless parameters: D* (the reduced asymptotic strength of the fluid-adsorber interaction, a function of temperature) and R* (the reduced radius of the pore). The phenomenon of hysteresis inherently related to capillary condensation is discussed. The connection to a previously proposed universality for cylindrical pores is also established.

  4. Exploring Cylindrical Solutions in Modified f(G) Gravity

    CERN Document Server

    Houndjo, M J S; Momeni, D; Myrzakulov, R

    2013-01-01

    We present cylindrically symmetric solutions for a type of the Gauss-Bonnet gravity, in details. We derive the full system of the field equations and show that there exist seven families of exact solutions for three forms of viable models. By applying the method based on the effective fluid energy momentum tensor components, we evaluate the mass per unit length for the solutions. From dynamical point of the view, by evaluating the null energy condition for these configurations, we show that in some cases the azimuthal pressure breaks the energy condition. This violation of the null energy condition predicts the existence of a cylindrical wormhole.

  5. Metallurgical Evaluation of the Five-Inch Cylindrical Induction Melter

    Energy Technology Data Exchange (ETDEWEB)

    Imrich, K.J.

    2000-08-15

    A metallurgical evaluation of the 5-inch cylindrical induction melter (CIM) vessel was performed by the Materials Technology Section to evaluate the metallurgical condition after operating for approximately 375 hours at 1400 to 1500 Degrees Celsius during a 2 year period. Results indicate that wall thinning and significant grain growth occurred in the lower portion of the conical section and the drain tube. No through-wall penetrations were found in the cylindrical and conical sections of the CIM vessel and only one leak site was identified in the drain tube. Failure of the drain tube was associated with a localized over heating and intercrystalline fracture.

  6. The Levitating Buddha: Constructing a Realistic Cylindrical Mirror Pseudo Image

    Science.gov (United States)

    Caussat, María Alicia; Rabal, Héctor; Muramatsu, Mikiya

    2006-10-01

    There are several interesting experiments involving image formation that can be easily implemented using mirrored foil, a very inexpensive material. When the foil is somewhat bent by holding its opposite edges and slightly pulling them together, cylindrical surfaces are generated. They behave as cylindrical mirrors, and circular or elliptical cross sections can be made. A project that can be easily built with the mirror foil is the generation of a pseudo image that is so compelling in its apparent reality that it can easily be taken to be the object itself.

  7. Nonlinear dynamo action in a precessing cylindrical container.

    Science.gov (United States)

    Nore, C; Léorat, J; Guermond, J-L; Luddens, F

    2011-07-01

    It is numerically demonstrated by means of a magnetohydrodynamics code that precession can trigger the dynamo effect in a cylindrical container. When the Reynolds number, based on the radius of the cylinder and its angular velocity, increases, the flow, which is initially centrosymmetric, loses its stability and bifurcates to a quasiperiodic motion. This unsteady and asymmetric flow is shown to be capable of sustaining dynamo action in the linear and nonlinear regimes. The magnetic field thus generated is unsteady and quadrupolar. These numerical evidences of dynamo action in a precessing cylindrical container may be useful for an experiment now planned at the Dresden sodium facility for dynamo and thermohydraulic studies in Germany.

  8. Optical trapping and optical binding using cylindrical vector beams

    Directory of Open Access Journals (Sweden)

    S. E. Skelton

    2011-09-01

    Full Text Available We report on the use of cylindrical vector beams for optical manipulation of micron and sub-micron sized particles using the methods of a single-beam gradient force trap (optical tweezers and an evanescent-field surface trap (optical binding. We have demonstrated a stable interferometric method for the synthesis of cylindrical vector beams (CVBs, and present measurements demonstrating polarization-controlled focal volume shaping using CVBs in an optical tweezers. Furthermore we show how appropriate combinations of CVBs corresponding to superpositions of optical fibre modes can be used for controlled trapping and trafficking of micro- and nanoparticles along a tapered optical fibre.

  9. Active Constrained Layer Damping of Thin Cylindrical Shells

    Science.gov (United States)

    RAY, M. C.; OH, J.; BAZ, A.

    2001-03-01

    The effectiveness of the active constrained layer damping (ACLD) treatments in enhancing the damping characteristics of thin cylindrical shells is presented. A finite element model (FEM) is developed to describe the dynamic interaction between the shells and the ACLD treatments. Experiments are performed to verify the numerical predictions. The obtained results suggest the potential of the ACLD treatments in controlling the vibration of cylindrical shells which constitute the major building block of many critical structures such as cabins of aircrafts, hulls of submarines and bodies of rockets and missiles.

  10. Analytic descriptions of cylindrical electromagnetic waves in a nonlinear medium

    Science.gov (United States)

    Xiong, Hao; Si, Liu-Gang; Yang, Xiaoxue; Wu, Ying

    2015-01-01

    A simple but highly efficient approach for dealing with the problem of cylindrical electromagnetic waves propagation in a nonlinear medium is proposed based on an exact solution proposed recently. We derive an analytical explicit formula, which exhibiting rich interesting nonlinear effects, to describe the propagation of any amount of cylindrical electromagnetic waves in a nonlinear medium. The results obtained by using the present method are accurately concordant with the results of using traditional coupled-wave equations. As an example of application, we discuss how a third wave affects the sum- and difference-frequency generation of two waves propagation in the nonlinear medium. PMID:26073066

  11. Gravitational collapse of a cylindrical null shell in vacuum

    Directory of Open Access Journals (Sweden)

    S. Khakshournia

    2008-03-01

    Full Text Available   Barrabès-Israel null shell formalism is used to study the gravitational collapse of a thin cylindrical null shell in vacuum. In general the lightlike matter shell whose history coincides with a null hypersurface is characterized by a surface energy density. In addition, a gravitational impulsive wave is present on this null hypersurface whose generators admit both the shear and expansion. In the case of imposing the cylindrical flatness the surface energy-momentum tensor of the matter shell on the null hypersurface vanishes and the null hyper- surface is just the history of the gravitational wave .

  12. Heavy-Ion Physics at a Fixed-Target Experiment Using the LHC Proton and Lead Beams (AFTER@LHC): Feasibility Studies for Quarkonium and Drell-Yan Production

    Science.gov (United States)

    Trzeciak, B.; Da Silva, C.; Ferreiro, E. G.; Hadjidakis, C.; Kikola, D.; Lansberg, J. P.; Massacrier, L.; Seixas, J.; Uras, A.; Yang, Z.

    2017-09-01

    We outline the case for heavy-ion-physics studies using the multi-TeV lead LHC beams in the fixed-target mode. After a brief contextual reminder, we detail the possible contributions of AFTER@LHC to heavy-ion physics with a specific emphasis on quarkonia. We then present performance simulations for a selection of observables. These show that Υ (nS), J/ψ and ψ (2S) production in heavy-ion collisions can be studied in new energy and rapidity domains with the LHCb and ALICE detectors. We also discuss the relevance to analyse the Drell-Yan pair production in asymmetric nucleus-nucleus collisions to study the factorisation of the nuclear modification of partonic densities and of further quarkonium states to restore their status of golden probes of the quark-gluon plasma formation.

  13. Mutation of Glycosylation Sites in BST-2 Leads to Its Accumulation at Intracellular CD63-Positive Vesicles without Affecting Its Antiviral Activity against Multivesicular Body-Targeted HIV-1 and Hepatitis B Virus

    Directory of Open Access Journals (Sweden)

    Zhu Han

    2016-02-01

    Full Text Available BST-2/tetherin blocks the release of various enveloped viruses including HIV-1 with a “physical tethering” model. The detailed contribution of N-linked glycosylation to this model is controversial. Here, we confirmed that mutation of glycosylation sites exerted an effect of post-translational mis-trafficking, leading to an accumulation of BST-2 at intracellular CD63-positive vesicles. BST-2 with this phenotype potently inhibited the release of multivesicular body-targeted HIV-1 and hepatitis B virus, without affecting the co-localization of BST-2 with EEA1 and LAMP1. These results suggest that N-linked glycosylation of human BST-2 is dispensable for intracellular virion retention and imply that this recently discovered intracellular tethering function may be evolutionarily distinguished from the canonical antiviral function of BST-2 by tethering nascent virions at the cell surface.

  14. Attospiral generation upon interaction of circularly polarized intense laser pulses with cone-like targets

    CERN Document Server

    Lécz, Zsolt

    2015-01-01

    Generation of high intensity attopulses is investigated in cylindrical geometry by using 3D particle-in-cell plasma simulation code. Due to the rotation symmetric target, a circularly polarized laser pulse is considered propagating on the axis of a hollow cone-like target. The large incidence angle and constant ponderomotive pressure leads to nano-bunching of relativistic electrons responsible for the laser-driven synchrotron emission. A numerical method is developed to find the source and direction of the coherent radiation that is responsible for the existence of attopulses. The intensity modulation in the harmonic spectrum is well described by the model of coherent synchrotron emission extended to the regime of higher order \\gamma-spikes. The spatial distribution of the higher harmonics resembles a spiral shape which gets focused into a small volume behind the target.

  15. Investigation of Space and Energy Distributions of Neutrons Generated in Lead Target and Uranium Blanket of the Electronuclear System "Energy plus Transmutation" under Irradiation with Protons at 1.5 GeV

    CERN Document Server

    Zhuk, I V; Krivopustov, M I; Sosnin, A N; Chultem, D; Vestmaer, V; Tumendelger, T; Zaveryukha, O S; Pavlyuk, A B

    2002-01-01

    The work contains the results of space-energy distributions of neutrons in U/Pb assembly, consisting of extended lead target and the model of natural uranium blanket irradiated with relativistic protons at 1.5 GeV. The research is carried out in the framework of a series of experiments using the model of subcritical heterogeneous electronuclear system at the Laboratory of High Energies, JINR, Dubna ("Investigation of Physical Aspects of Electronuclear Method of Energy Production and Transmutation of Radioactive Waste Using Beams from JINR Synchrophasotron/Nuclotron" - project "Energy plus Transmutation"). The results of measurements and calculations of ^{235}U, ^{238}U and ^{232}Th fission rate distributions as well as threshold spectral indexes {\\bar\\sigma_f^{^{232}Th}}/{\\bar\\sigma_f^{^{235}U}} and {\\bar\\sigma_f^{^{238}U}}/{\\bar\\sigma_f^{^{235}U}} along the radius of the target and model uranium blanket are presented. The results of measurements and calculations of ^{234}U, ^{236}U and ^{237}Np fission rate ...

  16. Study of 232Th(n, γ) and 232Th(n,f) reaction rates in a graphite moderated spallation neutron field produced by 1.6 GeV deuterons on lead target

    Science.gov (United States)

    Asquith, N. L.; Hashemi-Nezhad, S. R.; Westmeier, W.; Zhuk, I.; Tyutyunnikov, S.; Adam, J.

    2015-02-01

    The Gamma-3 assembly of the Joint Institute for Nuclear Research (JINR), Dubna, Russia is designed to emulate the neutron spectrum of a thermal Accelerator Driven System (ADS). It consists of a lead spallation target surrounded by reactor grade graphite. The target was irradiated with 1.6 GeV deuterons from the Nuclotron accelerator and the neutron capture and fission rate of 232Th in several locations within the assembly were experimentally measured. 232Th is a proposed fuel for envisaged Accelerator Driven Systems and these two reactions are fundamental to the performance and feasibility of 232Th in an ADS. The irradiation of the Gamma-3 assembly was also simulated using MCNPX 2.7 with the INCL4 intra-nuclear cascade and ABLA fission/evaporation models. Good agreement between the experimentally measured and calculated reaction rates was found. This serves as a good validation for the computational models and cross section data used to simulate neutron production and transport of spallation neutrons within a thermal ADS.

  17. Grape seed extract targets mitochondrial electron transport chain complex III and induces oxidative and metabolic stress leading to cytoprotective autophagy and apoptotic death in human head and neck cancer cells.

    Science.gov (United States)

    Shrotriya, Sangeeta; Deep, Gagan; Lopert, Pamela; Patel, Manisha; Agarwal, Rajesh; Agarwal, Chapla

    2015-12-01

    Head and neck squamous cell carcinoma (HNSCC) is a major killer worldwide and innovative measures are urgently warranted to lower the morbidity and mortality caused by this malignancy. Aberrant redox and metabolic status in HNSCC cells offer a unique opportunity to specifically target cancer cells. Therefore, we investigated the efficacy of grape seed extract (GSE) to target the redox and bioenergetic alterations in HNSCC cells. GSE treatment decreased the mitochondrial electron transport chain complex III activity, increased the mitochondrial superoxide levels and depleted the levels of cellular antioxidant (glutathione), thus resulting in the loss of mitochondrial membrane potential in human HNSCC Detroit 562 and FaDu cells. Polyethylene glycol-SOD addition reversed the GSE-mediated apoptosis without restoring complex III activity. Along with redox changes, GSE inhibited the extracellular acidification rate (representing glycolysis) and oxygen consumption rate (indicating oxidative phosphorylation) leading to metabolic stress in HNSCC cells. Molecular studies revealed that GSE activated AMP-activated protein kinase (AMPK), and suppressed Akt/mTOR/4E-BP1/S6K signaling in both Detroit 562 and FaDu cells. Interestingly, GSE increased the autophagic load specifically in FaDu cells, and autophagy inhibition significantly augmented the apoptosis in these cells. Consistent with in vitro results, in vivo analyses also showed that GSE feeding in nude mice activated AMPK and induced-autophagy in FaDu xenograft tumor tissues. Overall, these findings are innovative as we for the first time showed that GSE targets ETC complex III and induces oxidative and metabolic stress, thereby, causing autophagy and apoptotic death in HNSCC cells. © 2014 Wiley Periodicals, Inc.

  18. Measurements of gas and volatile element production rates from an irradiated molten lead and lead-bismuth spallation target with proton beams of 1 and 1.4 GeV; Mesures de taux de production d'elements gazeux et volatiles lors de reactions induites par des protons de 1 et 1,4 GeV sur des cibles epaisses de plomb et plomb-bismuth liquides

    Energy Technology Data Exchange (ETDEWEB)

    Tall, Y

    2008-03-15

    The integrated project EUROTRANS (European Research Programme for the Transmutation of High Level Nuclear Waste in an Accelerator Driven System) of the 6. EURATOM Framework Programme aims to demonstrate the transmutation of radioactive waste in ADS (Accelerator Driven Sub-critical system). It will carry out a first advanced design of an experimental facility to demonstrate the technical feasibility of transmutation, and will produce a conceptual design of an industrial facility dedicated to transmutation. An ADS consists of three fundamental elements: the accelerator of protons, the sub-critical core and the spallation target. SUBATECH (physique Sub-Atomique et des Technologies associees) laboratory is involved to the study of the chosen liquid lead-bismuth as a spallation ADS target. The irradiation of liquid lead-bismuth target with energetic proton beam generates in addition to neutrons, volatile and radioactive residues. In order to determine experimentally the production rates of gas and volatile elements following a spallation reaction in a lead-bismuth target, the experiment IS419 was performed at the ISOLDE facility at CERN (Centre Europeen de la Recherche Nucleaire). This experiment constitutes the frame of the thesis whose main objective is to assess and study the production and release rates of many gas and volatile element from the irradiated lead-bismuth target with an energetic proton beam. The obtained data are compared to Monte Carlo simulation code (MCNPX) results in order to test the intranuclear cascade model of Bertini and of Cugnon, and the evaporation options of Dresner and Schmidt. (author)

  19. Experimental study of impact-cratering damage on brittle cylindrical column model as a fundamental component of space architecture

    Science.gov (United States)

    Fujiwara, Akira; Onose, Naomi; Setoh, Masato; Nakamura, Akiko M.; Hiraoka, Kensuke; Hasegawa, Sunao; Okudaira, Kyoko

    2014-10-01

    The cylindrical column of brittle material processed from soil and rock is a fundamental component of architectures on the surface of solid bodies in the solar system. One of the most hazardous events for the structure is damaging by hypervelocity impacts by meteoroids and debris. In such a background, cylindrical columns made of plaster of Paris and glass-bead-sintered ceramic were impacted by spherical projectiles of nylon, glass, and steel at velocity of about 1-4.5 km/s. Measured crater radii, depth, and excavated mass expressed by a function of the cylinder radius are similar irrespective of the target material, if those parameters are normalized by appropriate parameters of the crater produced on the flat-surface target. The empirical scaling relations of the normalized crater radii and depth are provided. Using them, crater dimensions and excavated mass of crater on cylindrical surface of any radius can be predicted from the existing knowledge of those for flat surface. Recommendation for the minimum diameter of a cylinder so as to resist against a given impact is provided.

  20. Efficient Generation of Truncated Bessel Beams using Cylindrical Waveguides

    Science.gov (United States)

    Ilchenko, Vladimir S.; Mohageg, Makan; Savchenkov, Anatoliy A.; Matsko, Andrey B.; Maleki, Lute

    2007-01-01

    In this paper we address efficient conversion between a Gaussian beam (a truncated plane wave) and a truncated Bessel beam of agiven order, using cylindrical optical waveguides and whispering gallery mode resonators. Utilizing a generator based on waveguides combined with whispering gallery mode resonators, we have realized Bessel beams of the order of 200 with a conversion efficiency exceeding 10 %.

  1. A winning strategy for 3 x n Cylindrical Hex

    DEFF Research Database (Denmark)

    Huneke, S. C.; Hayward, R.; Toft, Bjarne

    2014-01-01

    For Cylindrical Hex on a board with circumference 3, we give a winning strategy for the end-to-end player. This is the first known winning strategy for odd circumference at least 3, answering a question of David Gale. (C) 2014 Elsevier B.V. All rights reserved....

  2. QUASI-PML FOR WAVES IN CYLINDRICAL COORDINATES. (R825225)

    Science.gov (United States)

    We prove that the straightforward extension of Berenger's original perfectly matched layer (PML) is not reflectionless at a cylindrical interface in the continuum limit. A quasi-PLM is developed as an absorbing boundary condition (ABC) for the finite-difference time-domain method...

  3. Imaging for Borehole Wall by a Cylindrical Linear Phased Array

    Institute of Scientific and Technical Information of China (English)

    ZHANG Bi-Xing; SHI Fang-Fang; WU Xian-Mei; GONG Jun-Jie; ZHANG Cheng-Guang

    2010-01-01

    @@ A new ultrasonic cylindrical linear phased array (CLPA) transducer is designed and fabricated for the borehole wall imaging in petroleum logging based on the previous theoretical researches.First,the CLPA transducer,which is made up of numbers of the piezoelectric elements distributed on the surface of a cylinder uniformly,is designed and fabricated.

  4. A circumferential crack in a cylindrical shell under tension.

    Science.gov (United States)

    Duncan-Fama, M. E.; Sanders, J. L., Jr.

    1972-01-01

    A closed cylindrical shell under uniform internal pressure has a slit around a portion of its circumference. Linear shallow shell theory predicts inverse square-root-type singularities in certain of the stresses at the crack tips. This paper reports the computed strength of these singularities for different values of a dimensionless parameter based on crack length, shell radius and shell thickness.

  5. 3D impurity inspection of cylindrical transparent containers

    DEFF Research Database (Denmark)

    Kragh, Mikkel Fly; Bjerge, Kim; Ahrendt, Peter

    2016-01-01

    This paper presents a method for automatically detecting and three-dimensionally positioning particles based on sequences of 2D images of rotating cylindrical transparent containers. The method can be used in the manufacturing industry by distinguishing between particles residing inside or outsid...

  6. Constitutive sensitivity of the oscillatory behaviour of hyperelastic cylindrical shells

    Science.gov (United States)

    Aranda-Iglesias, D.; Vadillo, G.; Rodríguez-Martínez, J. A.

    2015-12-01

    Free and forced nonlinear radial oscillations of a thick-walled cylindrical shell are investigated. The shell material is taken to be incompressible and isotropic within the framework of finite nonlinear elasticity. In comparison with previous seminal works dealing with the dynamic behaviour of hyperelastic cylindrical tubes, in this paper we have developed a broader analysis on the constitutive sensitivity of the oscillatory response of the shell. In this regard, our investigation is inspired by the recent works of Bucchi and Hearn (2013) [28,29], who carried out a constitutive sensitivity analysis of similar problem with hyperelastic cylindrical membranes subjected to static inflation. In the present paper we consider two different Helmholtz free-energy functions to describe the material behaviour: Mooney-Rivlin and Yeoh constitutive models. We carry out a systematic comparison of the results obtained by application of both constitutive models, paying specific attention to the critical initial and loading conditions which preclude the oscillatory response of the cylindrical tube. It has been found that these critical conditions are strongly dependent on the specific constitutive model selected, even though both Helmholtz free-energy functions were calibrated using the same experimental data.

  7. Capillary condensation of 4He in cylindrical pores

    Science.gov (United States)

    Urrutia, Ignacio; Szybisz, Leszek

    2004-10-01

    The adsorption of superfluid 4He confined into cylindrical pores of alkali metals is illustrated by looking at the case of Na. A density functional formalism is utilized for the theoretical description. The energetics and density profiles are determined as a function of the radius of cylinders and the filling fraction. These results are compared with those provided by a simple model recently proposed.

  8. Characterization of Density Profile of Cylindrical Pulsed Gas Jets

    Institute of Scientific and Technical Information of China (English)

    YU Quan-Zhi; LI Yu-Tong; ZhANG Jie; ZHENG Jun; LI Han-Ming; PENG Xiao-Yu; LI Kun

    2004-01-01

    @@ We investigated the characteristics of argon and helium gas jets produced by a cylindrical nozzle under pressures from I to 6 Mpa using a femtosecond laser interferometry. A radial parabolic distribution and an axial exponential distribution of the gas jet density profiles are identified. The results show that the density increases linearly with the backing pressure.

  9. Spherical coordinate descriptions of cylindrical and spherical Bessel beams.

    Science.gov (United States)

    Poletti, M A

    2017-03-01

    This paper derives a generalized spherical harmonic description of Bessel beams. The spherical harmonic description of the well-known cylindrical Bessel beams is reviewed and a family of spherical Bessel beams are introduced which can provide a number of azimuthal phase variations for a single beam radial amplitude. The results are verified by numerical simulations.

  10. On stability cylindrical shell with a viscoelastic core

    OpenAIRE

    2013-01-01

    Stability of cylindrical shell with a viscoelastic core is investigated under action both of external uniform pressure and constant temperature field. Core effect is modelled by means of Winkler formula. Besides of instant and prolonged critical parameters, the instability critical time are defined.

  11. Chaotic Vibrations of Closed Cylindrical Shells in a Temperature Field

    Directory of Open Access Journals (Sweden)

    A.V. Krysko

    2008-01-01

    Full Text Available Complex vibrations of cylindrical shells embedded in a temperature field are studied, and the Bubnov-Galerkin method in higher approximations and in the Fourier representation is applied. Both lack and influence of temperature field on the shell dynamics are analyzed.

  12. Internally Pressurized Spherical and Cylindrical Cavities in Rock Salt

    DEFF Research Database (Denmark)

    Krenk, Steen

    1978-01-01

    The paper deals with the stress distribution around cavities under pressure in an infinite, non-linear elastic material. A homogeneous stress state is assumed at infinity. For spherical and cylindrical cavities simple formulae are derived for the stress concentration, the extent of the non-linear...

  13. Development and Evaluation of Gold 3D Cylindrical Nanoelectrode Ensembles

    Institute of Scientific and Technical Information of China (English)

    CAO Li-Xin; YAN Pei-Sheng; SUN Ke-Ning; KIRK W Donald

    2007-01-01

    Gold 3D cylindrical nanoelectrode ensembles (NEEs), 100 nm in diameter and 500 nm in length were prepared by electroless template synthesis in polycarbonate filter membranes, followed by selective controlled chemical etching. The morphology of the nanowires and cylindrical NEEs was imaged by scanning electron microscopy. The protruding nanoelectrodes were in good parallel order. EDX study showed that the nanoelectrode elements consisted of pure gold. The electrochemical evaluation of the 3D electrodes was conducted using the well known [Fe(CN)6]3-/[Fe(CN)6]4- couple. Cyclic voltammgrams (CV) show a very low double layer charging current and a higher ratio of signal to background current than 2D disc NEEs. Electrochemical impedance spectroscopy (EIS) indicates that the 3D cylindrical NEEs effectively accelerate the charge transfer process, which is in consistent with the results of CV. The linear relationship with a slope of 0.5 between lg Ipc and lg v shows that linear diffusion is dominant on the 3D cylindrical NEEs at conventional scan rates.

  14. Static Solutions of Einstein's Equations with Cylindrical Symmetry

    Science.gov (United States)

    Trendafilova, C. S.; Fulling, S. A.

    2011-01-01

    In analogy with the standard derivation of the Schwarzschild solution, we find all static, cylindrically symmetric solutions of the Einstein field equations for vacuum. These include not only the well-known cone solution, which is locally flat, but others in which the metric coefficients are powers of the radial coordinate and the spacetime is…

  15. PCM thermal energy storage in cylindrical containers of various configurations

    Energy Technology Data Exchange (ETDEWEB)

    Mujumdar, A.S.; Ali Ashraf, F.; Menon, A.S.; Weber, M.E.

    1981-01-01

    Experimental measurements are reported for the time variation of surface-averaged rate of heat storage during melting in single, thin-walled cylindrical containers of copper filled with a commercially available paraffin wax. For the wax used the enthalpy-temperature curve was obtained using a differential scanning calorimeter according to the ASTM method. 12 refs.

  16. A cylindrical drift chamber with azimuthal and axial position readout

    Energy Technology Data Exchange (ETDEWEB)

    Bar-Yam, Z.; Cummings, J.P.; Dowd, J.P.; Eugenio, P.; Hayek, M.; Kern, W.; King, E.; Shenhav, N.; Chung, S.U.; Hackenburg, R.W.; Olchanski, C.; Weygand, D.P.; Willutzki, H.J.; Brabson, B.B.; Crittenden, R.R.; Dzierba, A.R.; Gunter, J.; Lindenbusch, R.; Rust, D.R.; Scott, E.; Smith, P.T.; Sulanke, T.; Teige, S.; Denisov, S.; Dushkin, A.; Kochetkov, V.; Lipaev, V.; Popov, A.; Shein, I.; Soldatov, A.; Anoshina, E.V.; Bodyagin, V.A.; Demianov, A.I.; Gribushin, A.M.; Kodolova, O.L.; Korotkikh, V.L.; Kostin, M.A.; Ostrovidov, A.I.; Sarycheva, L.I.; Sinev, N.B.; Vardanyan, I.N.; Yershov, A.A.; Adams, T.; Bishop, J.M.; Cason, N.M.; Sanjari, A.H.; LoSecco, J.M.; Manak, J.J.; Shephard, W.D.; Stienike, D.L.; Taegar, S.A.; Thompson, D.R.; Brown, D.S.; Pedlar, T.; Seth, K.K.; Wise, J.; Zhao, D.; Adams, G.S.; Napolitano, J.; Nozar, M.; Smith, J.A.; Witkowski, M. [Massachusetts Univ., North Dartmouth, MA (United States)]|[Brookhaven National Laboratory, Upton, L.I., NY 11973 (United States)]|[Indiana University, Bloomington, IN 47405 (United States)]|[Institute for High Energy Physics, Protvino (Russian Federation)]|[Institute of Nuclear Physics, Moscow State University, Moscow (Russian Federation)]|[University of Notre Dame, Notre Dame, IN 46556 (United States)]|[Northwestern University, Evanston, IL 60208 (United States)]|[Rensselaer Polytechnic Institute, Troy, NY 12180 (United States)

    1997-02-21

    A cylindrical multiwire drift chamber with axial charge-division has been constructed and used in experiment E852 at Brookhaven National Laboratory. It serves as a trigger element and as a tracking device for recoil protons in {pi}{sup -}p interactions. We describe the chamber`s design considerations, details of its construction, electronics, and performance characteristics. (orig.).

  17. Charged Cylindrical Polytropes with Generalized Polytropic Equation of State

    CERN Document Server

    Azam, M; Noureen, I; Rehman, M A

    2016-01-01

    We study the general formalism of polytropes in relativistic regime with generalized polytropic equations of state in the vicinity of cylindrical symmetry. We take charged anisotropic fluid distribution of matter with conformally flat condition for the development of general framework of polytropes. We discussed the stability of the model by Whittaker formula and concluded that one of the developed model is physically viable.

  18. Microfabrication of cylindrical microfluidic channel networks for microvascular research.

    Science.gov (United States)

    Huang, Zhouchun; Li, Xiang; Martins-Green, Manuela; Liu, Yuxin

    2012-10-01

    Current methods for formation of microvascular channel scaffolds are limited with non-circular channel cross-sections, complicated fabrication, and less flexibility in microchannel network design. To address current limitations in the creation of engineered microvascular channels with complex three-dimensional (3-D) geometries in the shape of microvessels, we have developed a reproducible, cost-effective, and flexible micromanufacturing process combined with photolithographic reflowable photoresist and soft lithography techniques to fabricate cylindrical microchannel and networks. A positive reflowable photoresist AZ P4620 was used to fabricate a master microchannel mold with semi-circular cross-sections. By the alignment and bonding of two polydimethylsiloxane (PDMS) microchannels replicated from the master mold together, a cylindrical microchannel or microchannel network was created. Further examination of the channel dimensions and surface profiles at different branching levels showed that the shape of the microfluidic channel was well approximated by a semi-circular surface, and a multi-level, multi-depth channel network was created. In addition, a computational fluidic dynamics (CFD) model was used to simulate shear flows and corresponding pressure distributions inside of the microchannel and channel network based on the dimensions of the fabricated channels. The fabricated multi-depth cylindrical microchannel network can provide platforms for the investigation of microvascular cells growing inside of cylindrical channels under shear flows and lumen pressures, and work as scaffolds for the investigation of morphogenesis and tubulogenesis.

  19. Strength Reliability Analysis of Stiffened Cylindrical Shells Considering Failure Correlation

    Institute of Scientific and Technical Information of China (English)

    Xu Bai; Liping Sun; Wei Qin; Yongkun Lv

    2014-01-01

    The stiffened cylindrical shell is commonly used for the pressure hull of submersibles and the legs of offshore platforms. There are various failure modes because of uncertainty with the structural size and material properties, uncertainty of the calculation model and machining errors. Correlations among failure modes must be considered with the structural reliability of stiffened cylindrical shells. However, the traditional method cannot consider the correlations effectively. The aim of this study is to present a method of reliability analysis for stiffened cylindrical shells which considers the correlations among failure modes. Firstly, the joint failure probability calculation formula of two related failure modes is derived through use of the 2D joint probability density function. Secondly, the full probability formula of the tandem structural system is given with consideration to the correlations among failure modes. At last, the accuracy of the system reliability calculation is verified through use of the Monte Carlo simulation. Result of the analysis shows the failure probability of stiffened cylindrical shells can be gained through adding the failure probability of each mode.

  20. Flow-induced vibrations of circular cylindrical structures. [LMFBR

    Energy Technology Data Exchange (ETDEWEB)

    Chen, S.

    1977-06-01

    The problems of flow-induced vibrations of circular cylindrical structures are reviewed. First, the general method of analysis and classification of structural responses are presented. Then, the presentation is broken up along the lines with stationary fluid, parallel flow, and cross flow. Finally, design considerations and future research needs are pointed out. 234 references.

  1. The cylindrical or tubiliform glands of Nephila clavipes.

    Science.gov (United States)

    Candelas, G C; Ortiz, A; Molina, C

    1986-02-01

    The cylindrical or tubiliform glands of the spider Nephila clavipes have been studied and compared to the large ampullates on which we have previously reported. The three pairs of cylindrical or tubiliform glands secrete the fibroin for the organism's egg case. Their solubilized luminar contents migrate as a homogeneous band in Sodium dodecyl sulfate polyacrylamide gel electrophoresis and turn out to be a larger protein than that produced by the large ampullates. The excised cylindrical glands remain metabolically active for several hours in a simple culture medium, where fibroin synthesis can be monitored through the incorporation of 14C alanine. The glands' response to a fibroin production stimulus does not reach the magnitude displayed by the large ampullates, but this is to be expected since their products supply different functions in this organism. This fibroin also seems to be elongated discontinuously. Translational pauses have been detected in the secretory epithelium of cylindrical and large ampullate glands of Nephila as well as in the silk glands of Bombyx mori. Since these glands produce the fibroin for the females egg case, they should prove to be an interesting model system.

  2. Employing a cylindrical single crystal in gas-surface dynamics

    NARCIS (Netherlands)

    Hahn, C.; Shan, J.; Liu, Y.; Berg, van den O.; Kleijn, A.W.; Juurlink, L.B.F.

    2012-01-01

    We describe the use of a polished, hollow cylindrical nickel single crystal to study effects of step edges on adsorption and desorption of gas phase molecules. The crystal is held in an ultra-high vacuum apparatus by a crystal holder that provides axial rotation about a [100] direction, and a crysta

  3. The Quality Factor of the Folded Cylindrical Helix

    Directory of Open Access Journals (Sweden)

    S. R. Best

    2009-12-01

    Full Text Available Any electrically small antenna can be impedance matched at any single frequency using a number of well known techniques. Once the small antenna is impedance matched, the primary characteristics of interest are its radiation efficiency, its operating bandwidth and to a lesser extent, its radiation patterns. The bandwidth of the small antenna is often quantified using the antenna's quality factor (Q since fundamental lower bounds for Q are defined in terms of the antenna's occupied volume. The lower bound on Q, also known as the Chu-limit, is defined in terms of the spherical volume occupied by the antenna. However, many small antenna designs are constrained to fit within volumes other than a sphere. To address this issue, Gustafsson et al derived lower bounds for antennas of arbitrary shape with a specific focus on cylindrical and planar shaped antennas. In this paper we consider the quality factor of the folded cylindrical helix, an antenna design that effectively utilizes the available cylindrical volume. We compare its Q to the Gustaffson limit as a function of length-to-diameter ratio, while maintaining a fixed value of ka, and show that it’s Q is at or above Gustafsson’s lower bound for cylindrical shaped antennas.

  4. Magnetoresistance of cylindrical nanowires with artificial pinning site

    KAUST Repository

    Vidal, Enrique Vilanova

    2015-05-01

    New concepts of magnetic memory devices are exploiting the movement of data bits by current induced domain wall motion. This concept has been widely explored with rectangular nanowires (NWs) or stripes both theoretically and experimentally [1]. In the case of cylindrical NWs not much progress has been made on the experimental side, despite its promising advantages like the absence of Walker breakdown [2].

  5. Leading men

    DEFF Research Database (Denmark)

    Bekker-Nielsen, Tønnes

    2016-01-01

    Through a systematic comparison of c. 50 careers leading to the koinarchate or high priesthood of Asia, Bithynia, Galatia, Lycia, Macedonia and coastal Pontus, as described in funeral or honorary inscriptions of individual koinarchs, it is possible to identify common denominators but also...

  6. Lead grids

    CERN Multimedia

    1974-01-01

    One of the 150 lead grids used in the multiwire proportional chamber g-ray detector. The 0.75 mm diameter holes are spaced 1 mm centre to centre. The grids were made by chemical cutting techniques in the Godet Workshop of the SB Physics.

  7. Polaron in a quasi 1D cylindrical quantum wire

    Directory of Open Access Journals (Sweden)

    I.Nsangou

    2005-01-01

    Full Text Available Polaron states in a quasi 1D cylindrical quantum wire with a parabolic confinement potential are investigated applying the Feynman variational principle. The effect of the wire radius on the polaron ground state energy level, the mass and the Fröhlich electron-phonon-coupling constant are obtained for the case of a quasi 1D cylindrical quantum wire. The effect of anisotropy of the structure on the polaron ground state energy level and the mass are also investigated. It is observed that as the wire radius tends to zero, the polaron mass and energy diverge logarithmically. The polaron mass and energy differ from the canonical strong-coupling behavior by the Fröhlich electron-phonon coupling constant and the radius of the quasi 1D cylindrical quantum wire that are expressed through a logarithmic function. Moreover, it is observed that the polaron energy and mass for strong coupling for the case of the quasi 1D cylindrical quantum wire are greater than those for bulk crystals. It is also observed that the anisotropy of the structure considerably affects both the polaron ground state energy level and the mass. It is found that as the radius of the cylindrical wire reduces, the regimes of the weak and intermediate coupling polaron shorten while the region of the strong coupling polaron broadens and extends into those of the weak and intermediate ones. Analytic expressions for the polaron ground state energy level and mass are derived for the case of strong coupling polarons.

  8. Who Leads China's Leading Universities?

    Science.gov (United States)

    Huang, Futao

    2017-01-01

    This study attempts to identify the major characteristics of two different groups of institutional leaders in China's leading universities. The study begins with a review of relevant literature and theory. Then, there is a brief introduction to the selection of party secretaries, deputy secretaries, presidents and vice presidents in leading…

  9. Reduction of sound transmission into a circular cylindrical shell using distributed vibration absorbers and Helmholtz resonators

    Science.gov (United States)

    Estève, Simon J.; Johnson, Marty E.

    2002-12-01

    A modal expansion method is used to model a cylindrical enclosure excited by an external plane wave. A set of distributed vibration absorbers (DVAs) and Helmholtz resonators (HRs) are applied to the structure to control the interior acoustic levels. Using an impedance matching method, the structure, the acoustic cavity, and the noise reduction devices are fully coupled to yield an analytical formulation of the structural kinetic energy and acoustic potential energy of a treated cylindrical cavity. Lightweight DVAs and small HRs tuned to the natural frequencies of the targeted structural and acoustic modes, respectively, result in significant acoustic and structural attenuation when the devices are optimally damped. Simulations show that significant interior noise reduction can only be achieved by adding damping to both structural and acoustic modes, which are resonant in the frequency bandwidth of interest. In order to be independent of the azimuth angle of the excitation and to avoid unwanted modal interactions, the devices are distributed evenly around the cylinder in rings. This treatment can only achieve good performance if the structure and the acoustic cavity are lightly damped.

  10. Complete Classification of Cylindrically Symmetric Static Spacetimes and the Corresponding Conservation Laws

    Directory of Open Access Journals (Sweden)

    Farhad Ali

    2016-08-01

    Full Text Available In this paper we find the Noether symmetries of the Lagrangian of cylindrically symmetric static spacetimes. Using this approach we recover all cylindrically symmetric static spacetimes appeared in the classification by isometries and homotheties. We give different classes of cylindrically symmetric static spacetimes along with the Noether symmetries of the corresponding Lagrangians and conservation laws.

  11. Facility target insert shielding assessment

    Energy Technology Data Exchange (ETDEWEB)

    Mocko, Michal [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-06

    Main objective of this report is to assess the basic shielding requirements for the vertical target insert and retrieval port. We used the baseline design for the vertical target insert in our calculations. The insert sits in the 12”-diameter cylindrical shaft extending from the service alley in the top floor of the facility all the way down to the target location. The target retrieval mechanism is a long rod with the target assembly attached and running the entire length of the vertical shaft. The insert also houses the helium cooling supply and return lines each with 2” diameter. In the present study we focused on calculating the neutron and photon dose rate fields on top of the target insert/retrieval mechanism in the service alley. Additionally, we studied a few prototypical configurations of the shielding layers in the vertical insert as well as on the top.

  12. Leading Cities

    DEFF Research Database (Denmark)

    Pogner, Karl-Heinz

    2017-01-01

    and technical engineering; Smart Cities) is very prominent in the traditional mass media discourse, in PR / PA of tech companies and traditional municipal administrations; whereas the second one (participation; Livable Cities) is mostly enacted in social media, (local) initiatives, movements, (virtual......) communities, new forms of urban governance in municipal administration and co-competitive city networks. Both forms seem to struggle for getting voice and power in the discourses, negotiations, struggles, and conflicts in Urban Governance about the question how to manage or lead (in) a city. Talking about...

  13. Comparative research on the methods for measuring the mode deflection angle of cylindrical resonator gyroscope

    Science.gov (United States)

    Wang, Kai; Fan, Zhenfang; Wang, Dongya; Wang, Yanyan; Pan, Yao; Qu, Tianliang; Xu, Guangming

    2016-10-01

    The existence of mode deflection angle in the cylindrical resonator gyroscope (CRG) leads to the signal drift on the detecting nodes of the gyro vibration and significantly decreases the performance of the CRG. Measuring the mode deflection angle efficiently is the foundation of tuning for the imperfect cylindrical shell resonator. In this paper, an optical method based on the measuring gyroscopic resonator's vibration amplitude with the laser Doppler vibrometer and an electrical method based on measuring the output voltage of the electrodes on the resonator are both presented to measure the mode deflection angle. Comparative experiments were implemented to verify the methodology and the results show that both of the two methods could recognize the mode deflection angle efficiently. The precision of the optical method relies on the number and position of testing points distributed on the resonator. The electrical method with simple circuit shows high accuracy of measuring in a less time compared to the optical method and its error source arises from the influence of circuit noise as well as the inconsistent distribution of the piezoelectric electrodes.

  14. Effect of bimodularity on frequency response of cylindrical panels using Galerkin time domain approach

    Indian Academy of Sciences (India)

    Kallol Khan; Badri Prasad Patel; Yogendra Nath

    2010-12-01

    The forced vibration analysis of bimodulus material laminated structures is a challenging problem due to non-smooth nonlinear nature of governing equations. The most commonly used direct time integration schemes show numerical instability and do not predict steady state response except for limited number of cases without considering in-plane inertia. This is due to the sudden change of restoring force from positive/negative half cycle to negative/positive half cycle exciting higher modes/harmonics at every instant of a cycle change leading to numerical instability in the time marching scheme. In the present work, Galerkin time domain approach is successfully used for the forced vibration analysis of bimodular cylindrical panels. The effect of bimodularity ratio on the frequency response of cylindrical panels for few typical geometrical and lamination parameters is studied for the first time. It is found that the positive half cycle amplitude is greater than the negative half cycle amplitude for $E_{2t}/E_{2c} < 1$ and is smaller for $E_{2t}/E_{2c} > 1$. Further, the percentage difference of positive and negative half cycle amplitudes decreases with the increase in $E_{2t}/E_{2c}$. The stresses under dynamic loading are different for positive and negative half of a vibration cycle.

  15. Cylindrical dilatation of the choledochus: a special type of congenital bile duct dilatation.

    Science.gov (United States)

    Todani, T; Watanabe, Y; Fujii, T; Toki, A; Uemura, S; Koike, Y

    1985-11-01

    Cylindrical dilatation of the choledochus develops in 20% of patients with congenital bile duct dilatation and usually has acute-angled unions of the pancreatobiliary ductal system. Symptoms generally develop in patients over 1 year of age. The patients frequently complain of abdominal pain, vomiting, and fever as in those with acute pancreatitis. Ultrasonography and infusion cholangiography are the most useful tools in making a correct diagnosis. A high amylase level in the bile caused by the refluxing of pancreatic juice through anomalous ductal unions is commonly observed. This is responsible for biliary perforation in infancy and possibly carcinoma arising in the bile duct. The amylase concentration in the serum at the time of epigastric pain often is high, which leads to the diagnosis of acute pancreatitis. However, evidence of pancreatic inflammation is seldom noted. Accordingly, amylase in the bile may enter the circulating blood through the denuded epithelium or sinusoids of the liver. Excision of the whole extrahepatic duct along with hepaticoenterostomy would be essential for the treatment of cylindrical dilatation of the bile duct, especially when an anomalous ductal union is present.

  16. Understanding the drivers for the development of design rules for the synthesis of cylindrical flexures

    Directory of Open Access Journals (Sweden)

    M. J. Telleria

    2012-04-01

    Full Text Available Cylindrical flexures (CFs, defined as flexures with only one finite radius of curvature loaded normal to the plane of curvature, present an interesting research direction in compliant mechanisms. CFs are constructed out of a cylindrical stock which leads to geometry, manufacturability, and compatibility advantages. Synthesis rules must be developed to design these new systems effectively. Current knowledge in flexure design pertains to straight-beam flexures or curved flexures loaded along the plane of curvature. CFs present a challenge because their mechanics differ from those of straight beams, and although their modelling has been researched thoroughly it has yet to be distilled into element and system creation rules. This paper uses models and finite element analysis to demonstrate that current design rules for straight-beam flexures are insufficient and inadequate for the design of CF systems. The presented discussion will show that CFs differ both at the element and systems levels, and therefore future research will focus on developing the three components of the building block approach: (i reworking of element mechanics models to reveal the parameters which cause the kinematics of the curved beam to differ from those of the straight beam, (ii development of a visual stiffness representation, and (iii formation of system creation rules.

  17. A cylindrical drift chamber for radiative muon capture experiments at TRIUMF

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, R.S.; Dawson, R.J.; Azuelos, G.; Robertson, B.C. (TRIUMF, Vancouver, BC (Canada)); Hasinoff, M.D.; Ahamad, S.; Gorringe, T.P. (Melbourne Univ., Parkville (Australia)); Serna-Angel, A.; Blecher, M.; Wright, D.H. (Virginia Polytechnic Inst. and State Univ., Blacksburg, VA (USA))

    1990-06-01

    In the Standard Model, the weak interaction is purely V-A in character. However in semileptonic reactions the strong force induces additional couplings. Radiative muon capture (RMC), {mu}{sup {minus}}{ital Z} {r arrow} {nu}({ital Z}{minus}1){gamma}, is a process which is particularly sensitive to the induced pseudoscalar coupling constant, {ital g{sub p}}, which is still very poorly determined experimentally. Due to the extremely small branching ratio ({approximately} 6 {times} 10{sup {minus}8}), the elementary reaction {mu}{sup {minus}}{ital p} {r arrow} {nu}{ital n}{gamma} has never been measured. Effort to date has concentrated on nuclear RMC where the branching ratio is much larger, but the interpretation of these results is hindered by nuclear structure uncertainties. A measurement is being carried out at TRIUMF to determine the rate of RMC on hydrogen to a precision of 8% leading to a determination of {ital g{sub p}} with an error of 10%. The detection system is based on a large volume cylindrical drift chamber, in an axial magnetic field, acting as an e{sup +}e{sup {minus}} pair spectrometer with a solid angle of {approx equal} 2 {pi}. The design, construction and performance of the cylindrical drift chamber are discussed.

  18. Free Vibration Characteristics of Cylindrical Shells Using a Wave Propagation Method

    Directory of Open Access Journals (Sweden)

    A. Ghoshal

    2001-01-01

    Full Text Available In the present paper, concept of a periodic structure is used to study the characteristics of the natural frequencies of a complete unstiffened cylindrical shell. A segment of the shell between two consecutive nodal points is chosen to be a periodic structural element. The present effort is to modify Mead and Bardell's approach to study the free vibration characteristics of unstiffened cylindrical shell. The Love-Timoshenko formulation for the strain energy is used in conjunction with Hamilton's principle to compute the natural propagation constants for two shell geometries and different circumferential nodal patterns employing Floquet's principle. The natural frequencies were obtained using Sengupta's method and were compared with those obtained from classical Arnold-Warburton's method. The results from the wave propagation method were found to compare identically with the classical methods, since both the methods lead to the exact solution of the same problem. Thus consideration of the shell segment between two consecutive nodal points as a periodic structure is validated. The variations of the phase constants at the lower bounding frequency for the first propagation band for different nodal patterns have been computed. The method is highly computationally efficient.

  19. Design algorithm for generatrix profile of cylindrical crowned rollers

    Directory of Open Access Journals (Sweden)

    Creţu Spiridon

    2017-01-01

    Full Text Available The cross-section of roller profile controls the pressure distribution in the contact area and radically affects the roller bearings basic dynamic load rating and rating lives. Today the most used roller profiles are the logarithmic profile and cylindrical-crowned (ZB profile. The logarithmic profile has a continuous evolution with no discontinuities till the intersection with the end fillet while ZB profile has two more discontinuities at the intersections points between the crowning circle and straight line generatrix. Using a semianalytical method, a numerical study has been carried out to find the optimum ZB profile for rollers incorporated in cylindrical rollers bearings. The basic reference rating life (L10_r has been used as optimization criterion.

  20. NONLINEAR THEORY OF DYNAMIC STABILITY FOR LAMINATED COMPOSITE CYLINDRICAL SHELLS

    Institute of Scientific and Technical Information of China (English)

    周承倜; 王列东

    2001-01-01

    Hamilton Principle was uaed to derive the general governing equations of nonlinear dynamic stability for laminated cylindrical shells in which, factors of nonlinear large deflection, transverse shear and longitudinal inertia force were concluded. Equations were solved by variational method. Analysis reveals that under the action of dynamic load,laminated cylindrical shells will fall into a state of parametric resonance and enter into the dynamic unstable region that causes dynamic instability of shells. Laminated shells of three typical composites were computed: i.e. T300/5 208 graphite epoxy E-glass epoxy, and ARALL shells. Results show that all factors will induce important influence for dynamic stability of laminated shells. So, in research of dynamic stability for laminated shells, to consider these factors is important.

  1. Selective decay in a long cylindrical geometry in SSX

    Science.gov (United States)

    Gray, T.; Brown, M.; Dandurand, D.; Zhang, X.

    2010-11-01

    A helical, minimum-energy relaxed plasma state has been observed in a long cylindrical volume. The cylinder is long enough (L/R = 13) so that the predicted minimum energy state is a close approximation to the infinite cylinder solution. The plasma is injected at v >=50 km/s by a coaxial magnetized plasma gun located at one end of the cylindrical volume. The relaxed state is rapidly attained in 1--2 axial Alfvén times after initiation of the plasma. Magnetic data is favorably compared with an analytical model. Magnetic data exhibits broadband fluctuations of the measured axial modes during the formation period. The broadband activity rapidly decays as the energy condenses into the lowest energy mode, which is in agreement to the minimum energy eigenstate of ∇xB = λB. Merging experiments are planned and additional data will be presented if available.

  2. Gamma ray absorption of cylindrical fissile material with dual shields

    Institute of Scientific and Technical Information of China (English)

    WU Chen-Yan; TIAN Dong-Feng; CHENG Yi-Ying; HUANG Yong-Yi; LU Fu-Quan; YANG Fu-Jia

    2005-01-01

    This work analyzed the gamma ray attenuation effect from the self-absorption and shield attenuation perspectively. An exact mathematical equation was given for the geometric factor of the cylindrical fissile material with dual shields. In addition, several approximation approaches suitable for real situation were discussed, especially in the radial and axial directions of the cylinders, since the G-factors have simple forms. Then the space distribution patterns of the G-factor were analyzed based on numerical result and effective ways to solve the geometric information of the cylindrical fissile material, the radii and the heights, were deduced. This method was checked and verified by numerical calculation. Because of the efficiency of the method, it is ideal for application in real situations, such as nuclear safeguards, which demands speed of detection and accuracy of geometric analysis.

  3. Dynamic response of cylindrical lined cavity in elastic medium

    Institute of Scientific and Technical Information of China (English)

    高盟; 王滢; 高广运

    2013-01-01

    An analytical solution to the transient dynamic response of a cylindrical lining subjected to an internal loading was presented and the dynamic interaction between the lining and surrounding soil was considered. The lining structure and the soil were treated as a cylindrical elastic shell and an infinite elastic compressible medium, respectively. A two-dimensional axisymmetric wave equation was derived from the governing equation of displacement by introducing the potential functions. Shell equation of motion was established based on continuity conditions. The closed-form solution for dynamic response of the lining due to an impact loading was obtained in Laplace transforms and inverse transforms. Detailed parametric studies were also presented to illustrate the influences of the Poisson ratio of soil, the dynamic shear moduli of both soil and lining and the thickness of lining on dynamic response of the lining.

  4. Fem Formulation of Heat Transfer in Cylindrical Porous Medium

    Science.gov (United States)

    Azeem; Khaleed, H. M. T.; Soudagar, Manzoor Elahi M.

    2017-08-01

    Heat transfer in porous medium can be derived from the fundamental laws of flow in porous region ass given by Henry Darcy. The fluid flow and energy transport inside the porous medium can be described with the help of momentum and energy equations. The heat transfer in cylindrical porous medium differs from its counterpart in radial and axial coordinates. The present work is focused to discuss the finite element formulation of heat transfer in cylindrical porous medium. The basic partial differential equations are derived using Darcy law which is the converted into a set of algebraic equations with the help of finite element method. The resulting equations are solved by matrix method for two solution variables involved in the coupled equations.

  5. Highly compressed nanosolution restricted in cylindrical carbon nanospaces

    Science.gov (United States)

    Nishi, Masayasu; Ohkubo, Takahiro; Tsurusaki, Kazuma; Itadani, Atsushi; Ahmmad, Bashir; Urita, Koki; Moriguchi, Isamu; Kittaka, Shigeharu; Kuroda, Yasushige

    2013-02-01

    We shed light on the specific hydration structure around a zinc ion of nanosolution restricted in a cylindrical micropore of single-wall carbon nanotube (SWNT) by comparison with the structure restricted in a cylindrical mesopore of multi-wall carbon nanotube (MWNT) and that of bulk aqueous solution. The average micropore width of open-pore SWNT was 0.87 nm which is equivalent to the size of a hydrated zinc ion having 6-hydrated water molecules. We could impregnate the zinc ions into the micropore of SWNT with negligible amounts of ion-exchanged species on surface functional groups by the appropriate oxidation followed by heat treatment under an inert condition. The results of X-ray absorption fine structure (XAFS) spectra confirmed that the proportion of dissolved species in nanospaces against the total adsorbed amounts of zinc ions on the open-pore SWNT and MWNT were 44 and 61%, respectively, indicating the formation of a dehydrated structure in narrower nanospaces. The structure parameters obtained by the analysis of XAFS spectra also indicate that the dehydrated and highly compressed hydration structure can be stably formed inside the cylindrical micropore of SWNT where the structure is different from that inside the slit-shaped micropore whose pore width is less than 1 nm. Such a unique structure needs not only a narrow micropore geometry which is equivalent to the size of a hydrated ion but also the cylindrical nature of the pore.We shed light on the specific hydration structure around a zinc ion of nanosolution restricted in a cylindrical micropore of single-wall carbon nanotube (SWNT) by comparison with the structure restricted in a cylindrical mesopore of multi-wall carbon nanotube (MWNT) and that of bulk aqueous solution. The average micropore width of open-pore SWNT was 0.87 nm which is equivalent to the size of a hydrated zinc ion having 6-hydrated water molecules. We could impregnate the zinc ions into the micropore of SWNT with negligible amounts of

  6. NONLINEAR FARADAY WAVES IN A PARAMETRICALLY EXCITED CIRCULAR CYLINDRICAL CONTAINER

    Institute of Scientific and Technical Information of China (English)

    菅永军; 鄂学全; 柏威

    2003-01-01

    In the cylindrical coordinate system, a singular perturbation theory of multiple-scale asymptotic expansions was developed to study single standing water wave mode bysolving potential equations of water waves in a rigid circular cylinder, which is subject to avertical oscillation. It is assumed that the fluid in the circular cylindrical vessel is inviscid ,incompressible and the motion is irrotational, a nonlinear amplitude equation with cubicand vertically excited terms of the vessel was derived by expansion of two-time scales withoutconsidering the effect of surface tension. It is shown by numerical computation that differentfree surface standing wave patterns will be formed in different excited frequencies andamplitudes. The contours of free surface waves are agreed well with the experimental resultswhich were carried out several years ago.

  7. Electrostatic resonances and optical responses of cylindrical clusters

    Science.gov (United States)

    Choy, C. W.; Xiao, J. J.; Yu, K. W.

    2008-12-01

    We developed a Green function formalism (GFF) for computing the electrostatic resonance in clusters of cylindrical particles. In the GFF, we take advantage of a surface integral equation to avoid matching the complicated boundary conditions on the surfaces of the particles. Numerical solutions of the eigenvalue equation yield a pole spectrum in the spectral representation. The pole spectrum can in turn be used to compute the optical response of these particles. For two cylindrical particles, the results are in excellent agreement with the exact results from the multiple image method and the normal mode expansion method. The results of this work can be extended to investigate the enhanced nonlinear optical responses of metal-dielectric composites, as well as optical switching in plasmonic waveguides.

  8. Elasticity solutions for functionally graded plates in cylindrical bending

    Institute of Scientific and Technical Information of China (English)

    YANG Bo; DING Hao-jiang; CHEN Wei-qiu

    2008-01-01

    The plate theory of functionally graded materials suggested by Mian and Spencer is extended to analyze the cylindrical bending problem of a functionally graded rectangular plate subject to uniform load. The expansion formula for displacements is adopted. While keeping the assumption that the material parameters can vary along the thickness direction in an arbitrary fashion, this paper considers orthotropic materials rather than isotropic materials. In addition, the traction-free condition on the top surface is replaced with the condition of uniform load applied on the top surface. The plate theory for the particular case of cylindrical bending is presented by considering an infinite extent in the y-direction. Effects of boundary conditions and material inhomogeneity on the static response of functionally graded plates are investigated through a numerical example.

  9. Enhanced converse magnetoelectric effect in cylindrical piezoelectric-magnetostrictive composites

    Science.gov (United States)

    Wu, Gaojian; Zhang, Ru; Zhang, Ning

    2016-10-01

    Enhanced converse magnetoelectric (ME) effect has been experimentally observed in cylindrical PZT-Terfenol-D piezoelectric-magnetostrictive bilayered composites, where the piezoelectric and magnetostrictive components are coupled through normal stresses instead of shear stresses that act in most of previous multiferroic composites. A theoretical model based on elastodynamics analysis has been proposed to describe the frequency response of converse ME effect for axial and radial modes in the bilayered cylindrical composites. The theory shows good agreement with the experimental results. The different variation tendency of resonant converse ME coefficient, as well as different variation rate of resonance frequency with bias magnetic field for axial and radial modes is interpreted in terms of demagnetizing effect. This work is of theoretical and technological significance for the application of converse ME effect as magnetic sensor, transducers, coil-free flux switch, etc.

  10. Rated MW from a heliostat field on cylindrical external receiver

    Energy Technology Data Exchange (ETDEWEB)

    Al-Rabghi, O.M.; Fathalah, K.A. [King Abdulaziz Univ., Mechanical Engineering Dep., Jeddah (Saudi Arabia); Elsayed, M.M. [Kuwait Univ., Mechanical Engineering Dep., Safat (Kuwait)

    1995-12-31

    Some of the reflected beam radiation from a heliostat field bypasses the receiver surface. The spillage factor which is a measure of how much of reflected beam radiation actually intercepted by the receiver surface, is calculated and plotted for easy access. The variation of the spillage with tower height, external cylindrical receiver size, dimensionless radial distance from the tower is computed and plotted. The value of the rated MW energy absorbed by an external cylindrical receiver, is investigated, and its relations to the tower height, the site location and the field radius are given. The effect of changing the radial spacing on the rated MW and the total number of heliostats in the field is also computed and depicted. The developed set of charts for the spillage factor are believed to be very useful for solar central receiver system design. (author) 7 figs., 21 refs.

  11. Plastic Buckling of Cylindrical Shells Under Transverse Loading

    Institute of Scientific and Technical Information of China (English)

    ZHANG Chonghou; LIU Yansheng; Yoshiaki Goto

    2008-01-01

    Thick cylindrical shells under transverse loading exhibit an elephant foot buckling mode, whereas moderately thick cylindrical shells show a diamond buckling mode. There exists some intermediate geome- try at which the transition between buckling modes can take place. This behavior is significantly influenced by the radius-to-thickness ratio and the material yield strength, rather than the length-to-radius ratio and the axial force. This paper presents a critical value at which the transition of buckling modes occurs as a func- tion of the radius-to-thickness ratio and the material yield strength. The result shows that the circumferential wave number of the diamond buckling mode increases with decreasing wall thickness. The strain concentra- tion is also intensified for the diamond buckling modes compared with the elephant foot buckling modes.

  12. Friction Compensation in the Upsetting of Cylindrical Test Specimens

    DEFF Research Database (Denmark)

    Christiansen, Peter; Martins, P. A. F.; Bay, Niels Oluf

    2016-01-01

    This manuscript presents a combined numerical andexperimental methodology for determining the stress-straincurve of metallic materials from the measurements of forceand displacement obtained in the axial compression of cylindrical test specimens with friction between the specimens and the platens...... model or combined friction models are utilized .Experimental results obtained from cylindrical and Rastegaev test specimens with different lubricants combined with the experimental determination of friction by means of ring compression tests allows compensating the effect of friction...... in the determination of the material flow curve. Comparison with the flow curves determined without friction compensation shows the viability of the proposed methodology. The proposed methodology is a simple and effective alternative to other solutions available in the literature and the pseudo-code supplied inthe...

  13. Settling of a cylindrical particle in a stagnant fluid

    DEFF Research Database (Denmark)

    Sørensen, Henrik; Rosendahl, Lasse; Yin, Chungen

    2007-01-01

    on their motion. In total 66 experiments were carried out with a particle Reynolds number in the range between 2000 and 15000. All experiments show a distinct oscillation around one of the particle minor axes. For all experiments the oscillating velocity is compared to the mean settling velocity, and it is found......The objective of this work is to collect data and develop models for cylindrical particles which could be used in numerical multiphase flow modeling. Trajectories of cylindrical particles settling in stagnant water are filmed from two directions in order to derive detailed information...... that the oscillating velocity increases with increasing mean settling velocity. Based on the experiment new expressions for drag and lift coefficient are proposed....

  14. Nonlinear dynamical behavior of shallow cylindrical reticulated shells

    Institute of Scientific and Technical Information of China (English)

    WANG Xin-zhi; LIANG Cong-xing; HAN Ming-jun; YEH Kai-yuan; WANG Gang

    2007-01-01

    By using the method of quasi-shells , the nonlinear dynamic equations of three-dimensional single-layer shallow cylindrical reticulated shells with equilateral triangle cell are founded. By using the method of the separating variable function, the transverse displacement of the shallow cylindrical reticulated shells is given under the conditions of two edges simple support. The tensile force is solved out from the compatible equations, a nonlinear dynamic differential equation containing second and third order is derived by using the method of Galerkin. The stability near the equilibrium point is discussed by solving the Floquet exponent and the critical condition is obtained by using Melnikov function. The existence of the chaotic motion of the single-layer shallow cylinmapping.

  15. Beamformer for Cylindrical Conformal Array of Non-isotropic Antennas

    Directory of Open Access Journals (Sweden)

    ZOU, L.

    2011-02-01

    Full Text Available The principal objective of this investigation is to facilitate minimum variance distortionless response (MVDR beamforming technique for a cylindrical conformal array geometry. An array of directional radiating elements is postulated to cover a surface typical of the cylinder of an aircraft or missile. Borrowing the analysis of conformal array antennas, the authors first derive a deterministic expression that describes the beam pattern of arbitrary weighted cylindrical conformal array. Then, making use of the MVDR beamforming, we derive the beamformer for uniform linear array (ULA of directional antennas which are different from the traditional omnidirectional elements. Thus, the pattern of a directional element is synthesized by the antennas on the same ring array, and we design the MVDR beamformer, which uses MVDR beamforming for ULA of the synthesized pattern. To demonstrate the validity of the method, and cylinder arrays are constructed and experimental results agree well with theoretical expectations.

  16. Performance of cylindrical-conical cyclones with different geometrical configurations

    Directory of Open Access Journals (Sweden)

    J.D.A.M. Santana

    2001-09-01

    Full Text Available The present work is a continuation of a study of the influence of geometric characteristics on the performance of reverse-flow cylindrical-conical cyclones. After studying the behavior of the pressure drop in previous work (Arnosti et al., 1998, here performance in terms of collection efficiency in the removal of particulate material is addressed. The independent variables considered in this study were inlet gas velocity (three velocities and the following dimensions of the cyclone: the cylindrical section (three heights and internal height of the gas exit duct (three heights. The tests were performed using an 3³ experimental design. Analysis of the results for overall efficiency was carried out using response surfaces and the statistical parameters were estimated from linear regression.

  17. On sector magnets or transverse electromagnetic fields in cylindrical coordinates

    CERN Document Server

    Zolkin, Timofey

    2016-01-01

    The Laplace's equations for the scalar and vector potentials describing electric or magnetic fields in cylindrical coordinates with translational invariance along azimuthal coordinate are considered. The series of special functions which, when expanded in power series in radial and vertical coordinates, in lowest order replicate the harmonic homogeneous polynomials of two variables are found. These functions are based on radial harmonics found by Edwin~M.~McMillan in his more-than-40-years "forgotten" article, which will be discussed. In addition to McMillan's harmonics, second family of adjoint radial harmonics is introduced, in order to provide symmetric description between electric and magnetic fields and to describe fields and potentials in terms of same special functions. Formulas to relate any transverse fields specified by the coefficients in the power series expansion in radial or vertical planes in cylindrical coordinates with the set of new functions are provided. This result is no doubt important f...

  18. Effective thermoelastic properties of composites with periodicity in cylindrical coordinates

    KAUST Repository

    Chatzigeorgiou, George

    2012-09-01

    The aim of this work is to study composites that present cylindrical periodicity in the microstructure. The effective thermomechanical properties of these composites are identified using a modified version of the asymptotic expansion homogenization method, which accounts for unit cells with shell shape. The microscale response is also shown. Several numerical examples demonstrate the use of the proposed approach, which is validated by other micromechanics methods. © 2012 Elsevier Ltd. All rights reserved.

  19. On the accuracy of the asymptotic theory for cylindrical shells

    DEFF Research Database (Denmark)

    Niordson, Frithiof; Niordson, Christian

    1999-01-01

    We study the accuracy of the lowest-order bending theory of shells, derived from an asymptotic expansion of the three-dimensional theory of elasticity, by comparing the results of this shell theory for a cylindrical shell with clamped ends with the results of a solution to the three......-dimensional problem. The results are also compared with those of some commonly used engineering shell theories....

  20. Rotating cylindrically symmetric Kaluza-Klein fluid model

    Indian Academy of Sciences (India)

    Ramesh Tikekar; L K Patel

    2000-09-01

    Kaluza-Klein field equations for stationary cylindrically symmetric fluid models in standard Einstein theory are formulated and a set of physically viable solutions is reported. This set is believed to be the first such Kaluza-Klein solutions and it includes the Kaluza-Klein counterpart of Davidson’s solution describing spacetime of a perfect fluid in rigid rotation about a regular axis.

  1. Charged cylindrical polytropes with generalized polytropic equation of state

    Energy Technology Data Exchange (ETDEWEB)

    Azam, M. [University of Education, Division of Science and Technology, Lahore (Pakistan); Mardan, S.A.; Noureen, I.; Rehman, M.A. [University of the Management and Technology, Department of Mathematics, Lahore (Pakistan)

    2016-09-15

    We study the general formalism of polytropes in the relativistic regime with generalized polytropic equations of state in the vicinity of cylindrical symmetry. We take a charged anisotropic fluid distribution of matter with a conformally flat condition for the development of a general framework of the polytropes. We discuss the stability of the model by the Whittaker formula and conclude that one of the models developed is physically viable. (orig.)

  2. Liquid-drop-like model for cylindrical helium systems

    Science.gov (United States)

    Szybisz, Leszek

    2000-08-01

    Free liquid 4He at T=0 K with cylindrical symmetry is studied. The ground-state energy and chemical potential are computed by using a density functional approach. A liquid-drop-like model is formulated for analyzing the behavior of these observables as a function of the size of the systems. It is shown that such a model allows to get precise information about the asymptotic values of the energy per particle and surface tension.

  3. Resonance in a cylindrical wraparound microstrip structure with superstrate

    Science.gov (United States)

    Wong, Kin-Lu; Tsai, Ruenn-Bo; Row, Jeen-Sheen

    1994-06-01

    Analysis of the resonance problem of a cylindrical wrap-around microstrip structure with superstrate is presented. In this study the rigorous full-wave formulation and Galerkin's method are used. The numerical convergence for the selected sinusoidal basis functions with edge singularity is also discussed. Numerical results of the superstrate loading effects on the real and imaginary parts of complex resonant frequency of the structures as a radiator and as a resonator are calculated and analyzed.

  4. Study of Contact Melting Inside Isothermally Heated Vertical Cylindrical Capsules

    Institute of Scientific and Technical Information of China (English)

    ChenWenzhen; ChengShangmo; 等

    1993-01-01

    Close-contact melting processes of phase change material(PCM) inside vertical cylindrical capsule are studied.PCM are heated bhy the capsule isothermalyy at the bottom and side.The theoretical formulas of the melting rate and thickness of liquid layer during the heat transfer process are obtained by analysis,which are convenient for engineering predictions.Finally,the factors that affect melting are discussed.and conclusions are drawn.

  5. Charged cylindrical polytropes with generalized polytropic equation of state

    Science.gov (United States)

    Azam, M.; Mardan, S. A.; Noureen, I.; Rehman, M. A.

    2016-09-01

    We study the general formalism of polytropes in the relativistic regime with generalized polytropic equations of state in the vicinity of cylindrical symmetry. We take a charged anisotropic fluid distribution of matter with a conformally flat condition for the development of a general framework of the polytropes. We discuss the stability of the model by the Whittaker formula and conclude that one of the models developed is physically viable.

  6. A curve fitting method for extrinsic camera calibration from a single image of a cylindrical object

    Science.gov (United States)

    Winkler, A. W.; Zagar, B. G.

    2013-08-01

    An important step in the process of optical steel coil quality assurance is to measure the proportions of width and radius of steel coils as well as the relative position and orientation of the camera. This work attempts to estimate these extrinsic parameters from single images by using the cylindrical coil itself as the calibration target. Therefore, an adaptive least-squares algorithm is applied to fit parametrized curves to the detected true coil outline in the acquisition. The employed model allows for strictly separating the intrinsic and the extrinsic parameters. Thus, the intrinsic camera parameters can be calibrated beforehand using available calibration software. Furthermore, a way to segment the true coil outline in the acquired images is motivated. The proposed optimization method yields highly accurate results and can be generalized even to measure other solids which cannot be characterized by the identification of simple geometric primitives.

  7. Ultra-wideband noise radar imaging of cylindrical PEC objects using diffraction tomography

    Science.gov (United States)

    Shin, Hee Jung; Narayanan, Ram M.; Rangaswamy, Muralidhar

    2014-05-01

    In this paper, we show that a single transmission of a random noise waveform may not sufficient to obtain a successful tomographic image of an object. In order to overcome this shortcoming, multiple independent and identically distributed (iid) random noise waveforms over a frequency range from 8 to 10 GHz are transmitted to reconstruct the final image of various objects. Diffraction tomography theorem is applied for each noise waveform transmission so that the image of the multiple objects is reconstructed based on the backward scattered field at the end of each noise waveform transmission realization. After all iid noise waveforms are transmitted, the final tomographic image of the target is reconstructed by averaging all obtained images from multiple transmissions. Several numerical simulations in the spatial frequency domain are performed, and the successful tomographic image of the multiple cylindrical PEC objects is achieved after transmission of multiple iid ultra-wideband (UWB) random noise waveforms.

  8. Analysis of cylindrical ramp compression experiment with radiography based surface fitting method

    Science.gov (United States)

    Martin, Matthew R.; Lemke, R. W.; McBride, Ryan D.; Davis, Jean-Paul; Knudson, M. D.

    2012-03-01

    The shockless compression of a cylindrical liner Z-pinch is explored as a method to obtain high pressure states while minimizing the entropy production in the target material. Experiments with beryllium liners on the Z-machine resulted in radiographic profiles at four different times in the liner's trajectory. From these results, we infer the longitudinally and azimuthally averaged material density, material pressure, and magnetic pressure along with their uncertainties. By combining these results with magnetohydrodynamic simulation, we obtain a pressure versus density response in solid beryllium up to 2.4Mbar. We conclude that the pressure versus density response for material samples in the 10Mbar range is achievable on the Z-machine with improved radiographic capability.

  9. Beltrami flow structure in a diffuser. Quasi-cylindrical approximation

    CERN Document Server

    González, Rafael; Sartarelli, Andrés Salvador; 10.4279/PIP.040002

    2012-01-01

    We determine the flow structure in an axisymmetric diffuser or expansion region connecting two cylindrical pipes when the inlet flow is a solid body rotation with a uniform axial flow of speeds Omega and U, respectively. A quasi-cylindrical approximation is made in order to solve the steady Euler equation, mainly the Bragg-Hawthorne equation. As in our previous work on the cylindrical region downstream [R Gonz\\'alez et al., Phys. Fluids 20, 24106 (2008); R. Gonz\\'alez et al., Phys. Fluids 22, 74102 (2010), R Gonz\\'alez et al., J. Phys.: Conf. Ser. 296, 012024 (2011)], the steady flow in the transition region shows a Beltrami flow structure. The Beltrami flow is defined as a field v_B that satisfies omega_B=nabla v_B= gamma v_B, with gamma = constant. We say that the flow has a Beltrami flow structure when it can be put in the form v = U e_z + Omega r e_theta + v_B, being U and Omega constants, i.e it is the superposition of a solid body rotation and translation with a Beltrami one. Therefore, those findings a...

  10. Modelization of coupled heat transfer inside a cylindrical glass block

    Energy Technology Data Exchange (ETDEWEB)

    Tanguier, J.L.; Kheiri, A.; Kleinclauss, J. [Faculte des Sciences, 54 - Vandoeuvre-les-Nancy (France)

    1995-01-01

    Modelization of coupled heat transfer inside a cylindrical glass block. In crystal industry, the furnaces used to warm up glass before forming are supplied with 4 bar pressure gas. They are noisy, polluting and high consumers of energy. To limit these effects and improve the energetic performances, an electrical infrared furnace is studied. To perfect it, it is necessary to identify the mechanisms of heat transfer which govern the evolution of the temperature into a cylindrical semitransparent media. After a long and thorough bibliography relative to the thermo-optical properties of crystal, the measurement of the field of temperature into the cylindrical block during the phases of working is led into the factory. To do this, it was necessary to adapt a reliable technical measurement device adjusted to industrial surrounding. A fundamental analysis of the results allows us to propose a model of the coupled heat transfer (radiation, conduction and convection) inside glass and between glass and its surroundings. The model is built on brightness and it is based on a triple discretization: temporal, spectral and zonal. This model provides the spectral distribution of the infrared radiation and the electrical power necessary to obtain a good heating of the crystal according to the manufactory charges. The first tests made with the experimental furnace, built by us, show that it is possible to warm up glass with infrared radiation and that this proceeding reduces the energy consumption and the nuisances. (authors). 19 refs., 7 figs.

  11. Tunnel Point Cloud Filtering Method Based on Elliptic Cylindrical Model

    Science.gov (United States)

    Zhua, Ningning; Jiaa, Yonghong; Luo, Lun

    2016-06-01

    The large number of bolts and screws that attached to the subway shield ring plates, along with the great amount of accessories of metal stents and electrical equipments mounted on the tunnel walls, make the laser point cloud data include lots of non-tunnel section points (hereinafter referred to as non-points), therefore affecting the accuracy for modeling and deformation monitoring. This paper proposed a filtering method for the point cloud based on the elliptic cylindrical model. The original laser point cloud data was firstly projected onto a horizontal plane, and a searching algorithm was given to extract the edging points of both sides, which were used further to fit the tunnel central axis. Along the axis the point cloud was segmented regionally, and then fitted as smooth elliptic cylindrical surface by means of iteration. This processing enabled the automatic filtering of those inner wall non-points. Experiments of two groups showed coincident results, that the elliptic cylindrical model based method could effectively filter out the non-points, and meet the accuracy requirements for subway deformation monitoring. The method provides a new mode for the periodic monitoring of tunnel sections all-around deformation in subways routine operation and maintenance.

  12. Fluid-structure coupled analysis of underwater cylindrical shells

    Institute of Scientific and Technical Information of China (English)

    AI Shang-mao; SUN Li-ping

    2008-01-01

    Underwater cylindrical shell structures have been found a wide of application in many engineering fields,such as the element of marine,oil platforms,etc.The coupled vibration analysis is a hot issue for these underwater structures.The vibration characteristics of underwater structures are influenced not only by hydrodynamic pressure but also by hydrostatic pressure corresponding to different water depths.In this study,an acoustic finite element method was used to evaluate the underwater structures.Taken the hydrostatic pressure into account in terms of initial stress stiffness,an acoustical fluid-structure coupled analysis of underwater cylindrical shells has been made to study the effect of hydrodynamic pressures on natural frequency and sound radiation.By comparing with the frequencies obtained by the acoustic finite element method and by the added mass method based on the Bessel function,the validity of present analysis was checked.Finally,test samples of the sound radiation of stiffened cylindrical shells were acquired by a harmonic acoustic analysis.The results showed that hydrostatic pressure plays an important role in determining a large submerged body motion,and the characteristics of sound radiation change with water depth. Furthermore,the analysis methods and the results are of significant reference value for studies of other complicated submarine structures.

  13. Microfluidic step-emulsification in a cylindrical geometry

    Science.gov (United States)

    Chakraborty, Indrajit; Leshansky, Alexander M.

    2016-11-01

    The model microfluidic device for high-throughput droplet generation in a confined cylindrical geometry is investigated numerically. The device comprises of core-annular pressure-driven flow of two immiscible viscous liquids through a cylindrical capillary connected co-axially to a tube of a larger diameter through a sudden expansion, mimicking the microfluidic step-emulsifier (1). To study this problem, the numerical simulations of axisymmetric Navier-Stokes equations have been carried out using an interface capturing procedure based on coupled level set and volume-of-fluid (CLSVOF) methods. The accuracy of the numerical method was favorably tested vs. the predictions of the linear stability analysis of core-annular two-phase flow in a cylindrical capillary. Three distinct flow regimes can be identified: the dripping (D) instability near the entrance to the capillary, the step- (S) and the balloon- (B) emulsification at the step-like expansion. Based on the simulation results we present the phase diagram quantifying transitions between various regimes in plane of the capillary number and the flow-rate ratio. MICROFLUSA EU H2020 project.

  14. Determining the axis orientation of cylindrical magnetic flux rope

    Science.gov (United States)

    Rong, Zhaojin; Wan, Weixing; Shen, Chao; Zhang, Tielong; Lui, Anthony; Wang, Yuming; Dunlop, malcolm; Zhang, Yongcun; Zong, Qiugang

    2013-04-01

    We develop a new simple method for inferring the orientation of a magnetic flux rope, which is assumed to be a time-independent cylindrically symmetric structure via the direct single-point analysis of magnetic field structure. The model tests demonstrate that, for the cylindrical flux rope regardless of whether it is force-free or not, the method can consistently yield the axis orientation of the flux rope with higher accuracy and stability than the minimum variance analysis of the magnetic field and the Grad-Shafranov reconstruction technique. Moreover, the radial distance to the axis center and the current density can also be estimated consistently. Application to two actual flux transfer events observed by the four satellites of the Cluster mission demonstrates that the method is more appropriate to be used for the inner part of flux rope, which might be closer to the cylindrical structure, showing good agreement with the results obtained from the optimal Grad-Shafranov reconstruction and the least squares technique of Faraday's law, but fails to produce such agreement for the outer satellite that grazes the flux rope. Therefore, the method must be used with caution.

  15. Characteristics of Cylindrical Microwave Plasma Source at Low Pressure

    Science.gov (United States)

    Park, Seungil; Youn, S.; Kim, S. B.; Yoo, S. J.

    2016-10-01

    A microwave plasma source with a cylindrical resonance cavity has been proposed to generate the plasma at low pressure. This plasma source consists of magnetron, waveguide, antenna, and cavity. The microwave generating device is a commercial magnetron with 1 kW output power at the frequency of 2.45 GHz. The microwave is transmitted through the rectangular waveguide with the whistle shape, and coupled to the cavity by the slot antenna. The resonant mode of the cylindrical cavity is the TE111 mode. The operating pressure is between 0.1 Torr and 0.3 Torr with the Argon and nitrogen gas. The electron temperature and electron number density of argon plasma were measured with the optical emission spectroscopy measurement. And Ar1s5 metastable density was measured using tunable diode laser absorption spectroscopy (TDLAS). The plasma diagnostic results of a cylindrical microwave plasma source would be described in this study. This work was supported by R&D Program of ``Plasma Advanced Technology for Agriculture and Food (Plasma Farming)'' through the National Fusion Research Institute of Korea (NFRI) funded by the Government funds.

  16. Optimization analysis on assembly interference of cylindrical roller bearings

    Directory of Open Access Journals (Sweden)

    Zhen-huan Ye

    2015-07-01

    Full Text Available Distribution of loads and contact stress has a great influence on fatigue life of bearings. In view of the fact that the nonload area is ubiquitous in cylindrical roller bearings, there is a method for prolonging the fatigue life design by adjusting the working clearance of cylindrical roller bearings. In this article, optimization model of fatigue life of cylindrical roller bearings is developed with a quasi-dynamic method and calculated method of bearing life based on micro-area contact, considering the effect of assembly interference, temperature rise, and high-speed centrifugation. Aiming to the different geometry parameters and operating parameters of bearings, the effects of assembly interference on bearing fatigue life are discussed. The results show that the optimum fatigue life of roller bearings is achieved at negative working clearance with the loads distributed evenly within half ring. The optimum working clearance of roller bearings is not influenced by radial load. But with the increase in pitch diameter or decrease in rolling elements, the optimum assembly interference increases, and accelerating revolution of roller bearings will increase the optimum assembly interference as well.

  17. Cylindrical Effects on Magneto-Rayleigh-Taylor Instability

    Science.gov (United States)

    Weis, Matthew; Lau, Yue Ying; Gilgenbach, Ronald; Jennings, Christopher; Hess, Mark

    2012-10-01

    This paper concentrates on the effects of cylindrical geometry on the magneto-Rayleigh-Taylor instability (MRT), a major concern in the magnetized liner inertial fusion concept (MagLIF) [1]. Several issues are being studied, such as the Bell-Plesset effect [2], the effects of magnetic shear and feedthrough [3], and the nonzero MRT growth rate that remains (but was hardly noticed) in the k = m = 0 limit in Harris' seminal paper on a cylindrical liner [4], where k and m are respectively the azimuthal and axial wavenumber. We shall use simulation and direct integration of the eigenvalue equation to investigate the importance of the cylindrical geometry, which is particularly relevant in the final stage of compression in the MagLIF concept. [4pt] [1] S. A. Slutz, et. al, Phys. Plasmas 17, 056303 (2010). [0pt] [2] G. I. Bell, Los Alamos Scientific Laboratory, Report LA-1321 (1951); M. S. Plesset, J. Appl. Phys. 25, 96 (1954).[0pt] [3] P. Zhang et al., Phys. Plasmas 19, 200703 (2012); Y. Y. Lau et al., Phys. Rev. E 83, 006405 (2011). [0pt] [4] E. G. Harris, Phys. Fluids 5, 1057 (1962).

  18. Chain-Based Communication in Cylindrical Underwater Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Nadeem Javaid

    2015-02-01

    Full Text Available Appropriate network design is very significant for Underwater Wireless Sensor Networks (UWSNs. Application-oriented UWSNs are planned to achieve certain objectives. Therefore, there is always a demand for efficient data routing schemes, which can fulfill certain requirements of application-oriented UWSNs. These networks can be of any shape, i.e., rectangular, cylindrical or square. In this paper, we propose chain-based routing schemes for application-oriented cylindrical networks and also formulate mathematical models to find a global optimum path for data transmission. In the first scheme, we devise four interconnected chains of sensor nodes to perform data communication. In the second scheme, we propose routing scheme in which two chains of sensor nodes are interconnected, whereas in third scheme single-chain based routing is done in cylindrical networks. After finding local optimum paths in separate chains, we find global optimum paths through their interconnection. Moreover, we develop a computational model for the analysis of end-to-end delay. We compare the performance of the above three proposed schemes with that of Power Efficient Gathering System in Sensor Information Systems (PEGASIS and Congestion adjusted PEGASIS (C-PEGASIS. Simulation results show that our proposed 4-chain based scheme performs better than the other selected schemes in terms of network lifetime, end-to-end delay, path loss, transmission loss, and packet sending rate.

  19. A mathematical model of microalgae growth in cylindrical photobioreactor

    Science.gov (United States)

    Bakeri, Noorhadila Mohd; Jamaian, Siti Suhana

    2017-08-01

    Microalgae are unicellular organisms, which exist individually or in chains or groups but can be utilized in many applications. Researchers have done various efforts in order to increase the growth rate of microalgae. Microalgae have a potential as an effective tool for wastewater treatment, besides as a replacement for natural fuel such as coal and biodiesel. The growth of microalgae can be estimated by using Geider model, which this model is based on photosynthesis irradiance curve (PI-curve) and focused on flat panel photobioreactor. Therefore, in this study a mathematical model for microalgae growth in cylindrical photobioreactor is proposed based on the Geider model. The light irradiance is the crucial part that affects the growth rate of microalgae. The absorbed photon flux will be determined by calculating the average light irradiance in a cylindrical system illuminated by unidirectional parallel flux and considering the cylinder as a collection of differential parallelepipeds. Results from this study showed that the specific growth rate of microalgae increases until the constant level is achieved. Therefore, the proposed mathematical model can be used to estimate the rate of microalgae growth in cylindrical photobioreactor.

  20. Research on cylindrical indexing cam’s unilateral machining

    Directory of Open Access Journals (Sweden)

    Junhua Chen

    2015-08-01

    Full Text Available The cylindrical cam ridge of the indexer is a spatial curved surface, which is difficult to design and machine. The cylindrical cam has some defects after machining because conventional machining methods have inaccuracies. This article aims at proposing a precise way to machine an indexing cam, using basic motion analysis and analytic geometry approach. Analytical methodology is first applied in the cam’s motion analysis, to obtain an error-free cam follower’s trajectory formula, and then separate the continuous trajectory curve by thousandth resolution, to create a three-dimensional discrete trajectory curve. Planar formulae and spherical formulae can be built on the loci. Based on the machine principle, the cutting cutter’s position and orientation will be taken into account. This article calculates the formula set as presented previously and obtains the ultimate cutter path coordinate value. The new error-free cutter path trajectory is called the unilateral machining trajectory. The earned results will compile into numerical control processing schedule. This processing methodology gives a convenient and precision way to manufacture a cylindrical indexing cam. Experimental results are also well supported.

  1. Chain-based communication in cylindrical underwater wireless sensor networks.

    Science.gov (United States)

    Javaid, Nadeem; Jafri, Mohsin Raza; Khan, Zahoor Ali; Alrajeh, Nabil; Imran, Muhammad; Vasilakos, Athanasios

    2015-01-01

    Appropriate network design is very significant for Underwater Wireless Sensor Networks (UWSNs). Application-oriented UWSNs are planned to achieve certain objectives. Therefore, there is always a demand for efficient data routing schemes, which can fulfill certain requirements of application-oriented UWSNs. These networks can be of any shape, i.e., rectangular, cylindrical or square. In this paper, we propose chain-based routing schemes for application-oriented cylindrical networks and also formulate mathematical models to find a global optimum path for data transmission. In the first scheme, we devise four interconnected chains of sensor nodes to perform data communication. In the second scheme, we propose routing scheme in which two chains of sensor nodes are interconnected, whereas in third scheme single-chain based routing is done in cylindrical networks. After finding local optimum paths in separate chains, we find global optimum paths through their interconnection. Moreover, we develop a computational model for the analysis of end-to-end delay. We compare the performance of the above three proposed schemes with that of Power Efficient Gathering System in Sensor Information Systems (PEGASIS) and Congestion adjusted PEGASIS (C-PEGASIS). Simulation results show that our proposed 4-chain based scheme performs better than the other selected schemes in terms of network lifetime, end-to-end delay, path loss, transmission loss, and packet sending rate.

  2. Fabrication and analysis of cylindrical resin AFM microcantilevers

    Energy Technology Data Exchange (ETDEWEB)

    Cheneler, D., E-mail: D.Cheneler@bham.ac.uk [School of Mechanical Engineering, The University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom); Bowen, J. [School of Chemical Engineering, The University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom); Leigh, S.J.; Purssell, C.P.; Billson, D.R.; Hutchins, D.A. [School of Engineering, University of Warwick, Coventry CV4 7AL (United Kingdom); Ward, M.C.L. [School of Mechanical Engineering, The University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom)

    2011-07-15

    In this paper a new method of fabricating cylindrical resin microcantilevers using the Direct Digital Manufacturing (DDM) technique of Micro-stereolithography (MSL) is described. The method is rapid and commercially viable, allowing the fabrication of atomic force microscope (AFM) cantilevers which exhibit much larger spring constants than those currently commercial available. This allows for experimentation in a force regime orders of magnitude higher than currently possible using the AFM. This makes these cantilevers ideally suited for AFM-based depth sensing indentation. Due to their geometry, the assumptions used in the standard Euler-Bernoulli beam theory usually used to analyse AFM cantilevers may no longer be valid. Therefore approximate analytical solutions based on Timoshenko beam theory have been derived for the stiffness and resonant frequency of these cantilevers. Prototypes of the cantilevers have been fabricated and tested. Results show good agreement between experiment and theory. -- Highlights: {yields} Direct Digital Manufacturing (DDM) has been used to make commercially viable AFM cantilevers. {yields} Analytical expressions for resonant frequency of Timoshenko beams has been derived. {yields} Dynamics of cylindrical AFM cantilevers has been discussed. {yields} Expressions for dynamic properties of conical AFM cantilevers has been derived. {yields} Effect of metallisation of cylindrical AFM cantilevers has been discussed.

  3. TUNNEL POINT CLOUD FILTERING METHOD BASED ON ELLIPTIC CYLINDRICAL MODEL

    Directory of Open Access Journals (Sweden)

    N. Zhu

    2016-06-01

    Full Text Available The large number of bolts and screws that attached to the subway shield ring plates, along with the great amount of accessories of metal stents and electrical equipments mounted on the tunnel walls, make the laser point cloud data include lots of non-tunnel section points (hereinafter referred to as non-points, therefore affecting the accuracy for modeling and deformation monitoring. This paper proposed a filtering method for the point cloud based on the elliptic cylindrical model. The original laser point cloud data was firstly projected onto a horizontal plane, and a searching algorithm was given to extract the edging points of both sides, which were used further to fit the tunnel central axis. Along the axis the point cloud was segmented regionally, and then fitted as smooth elliptic cylindrical surface by means of iteration. This processing enabled the automatic filtering of those inner wall non-points. Experiments of two groups showed coincident results, that the elliptic cylindrical model based method could effectively filter out the non-points, and meet the accuracy requirements for subway deformation monitoring. The method provides a new mode for the periodic monitoring of tunnel sections all-around deformation in subways routine operation and maintenance.

  4. Sub-aperture stitching test of a cylindrical mirror with large aperture

    Science.gov (United States)

    Xue, Shuai; Chen, Shanyong; Shi, Feng; Lu, Jinfeng

    2016-09-01

    Cylindrical mirrors are key optics of high-end equipment of national defense and scientific research such as high energy laser weapons, synchrotron radiation system, etc. However, its surface error test technology develops slowly. As a result, its optical processing quality can not meet the requirements, and the developing of the associated equipment is hindered. Computer Generated-Hologram (CGH) is commonly utilized as null for testing cylindrical optics. However, since the fabrication process of CGH with large aperture is not sophisticated yet, the null test of cylindrical optics with large aperture is limited by the aperture of the CGH. Hence CGH null test combined with sub-aperture stitching method is proposed to break the limit of the aperture of CGH for testing cylindrical optics, and the design of CGH for testing cylindrical surfaces is analyzed. Besides, the misalignment aberration of cylindrical surfaces is different from that of the rotational symmetric surfaces since the special shape of cylindrical surfaces, and the existing stitching algorithm of rotational symmetric surfaces can not meet the requirements of stitching cylindrical surfaces. We therefore analyze the misalignment aberrations of cylindrical surfaces, and study the stitching algorithm for measuring cylindrical optics with large aperture. Finally we test a cylindrical mirror with large aperture to verify the validity of the proposed method.

  5. Comparison of flat cleaved and cylindrical diffusing fibers as treatment sources for interstitial photodynamic therapy

    Energy Technology Data Exchange (ETDEWEB)

    Baran, Timothy M., E-mail: timothy.baran@rochester.edu; Foster, Thomas H. [Department of Imaging Sciences, University of Rochester, Rochester, New York 14642 (United States)

    2014-02-15

    Purpose: For interstitial photodynamic therapy (iPDT) of bulky tumors, careful treatment planning is required in order to ensure that a therapeutic dose is delivered to the tumor, while minimizing damage to surrounding normal tissue. In clinical contexts, iPDT has typically been performed with either flat cleaved or cylindrical diffusing optical fibers as light sources. Here, the authors directly compare these two source geometries in terms of the number of fibers and duration of treatment required to deliver a prescribed light dose to a tumor volume. Methods: Treatment planning software for iPDT was developed based on graphics processing unit enhanced Monte Carlo simulations. This software was used to optimize the number of fibers, total energy delivered by each fiber, and the position of individual fibers in order to deliver a target light dose (D{sub 90}) to 90% of the tumor volume. Treatment plans were developed using both flat cleaved and cylindrical diffusing fibers, based on tissue volumes derived from CT data from a head and neck cancer patient. Plans were created for four cases: fixed energy per fiber, fixed number of fibers, and in cases where both or neither of these factors were fixed. Results: When the number of source fibers was fixed at eight, treatment plans based on flat cleaved fibers required each to deliver 7180–8080 J in order to deposit 90 J/cm{sup 2} in 90% of the tumor volume. For diffusers, each fiber was required to deliver 2270–2350 J (333–1178 J/cm) in order to achieve this same result. For the case of fibers delivering a fixed 900 J, 13 diffusers or 19 flat cleaved fibers at a spacing of 1 cm were required to deliver the desired dose. With energy per fiber fixed at 2400 J and the number of fibers fixed at eight, diffuser fibers delivered the desired dose to 93% of the tumor volume, while flat cleaved fibers delivered this dose to 79%. With both energy and number of fibers allowed to vary, six diffusers delivering 3485–3600 J

  6. Thermal effects in tissues induced by interstitial irradiation of near infrared laser with a cylindrical diffuser

    Science.gov (United States)

    Le, Kelvin; Johsi, Chet; Figueroa, Daniel; Goddard, Jessica; Li, Xiaosong; Towner, Rheal A.; Saunders, Debra; Smith, Nataliya; Liu, Hong; Hode, Tomas; Nordquist, Robert E.; Chen, Wei R.

    2011-03-01

    Laser immunotherapy (LIT), using non-invasive laser irradiation, has resulted in promising outcomes in the treatment of late-stage cancer patients. However, the tissue absorption of laser light limits the clinical applications of LIT in patients with dark skin, or with deep tumors. The present study is designed to investigate the thermal effects of interstitial irradiation using an 805-nm laser with a cylindrical diffuser, in order to overcome the limitations of the non-invasive mode of treatment. Cow liver and rat tumors were irradiated using interstitial fiber. The temperature increase was monitored by thermocouples that were inserted into the tissue at different sites around the cylinder fiber. Three-dimensional temperature distribution in target tissues during and after interstitial laser irradiation was also determined by Proton Resonance Frequency. The preliminary results showed that the output power of laser and the optical parameters of the target tissue determined the light distribution in the tissue. The temperature distributions varied in the tissue according to the locations relative to the active tip of the cylindrical diffuser. The temperature increase is strongly related to the laser power and irradiation time. Our results using thermocouples and optical sensors indicated that the PRF method is reliable and accurate for temperature determination. Although the inhomogeneous biological tissues could result in temperature fluctuation, the temperature trend still can be reliable enough for the guidance of interstitial irradiation. While this study provides temperature profiles in tumor tissue during interstitial irradiation, the biological effects of the irradiation remain unclear. Future studies will be needed, particularly in combination with the application of immunostimulant for inducing tumor-specific immune responses in the treatment of metastatic tumors.

  7. A new analytical drain current model of cylindrical gate silicon tunnel FET with source δ-doping

    Science.gov (United States)

    Dash, Sidhartha; Jena, Biswajit; Mishra, Guru Prasad

    2016-09-01

    A new δ-doped cylindrical gate silicon tunnel FET (DCG-TFET) analytical model is developed and investigated extensively, with the aim of addressing the challenges of the conventional CG-TFET. The improvement in tunneling probability of charge carriers has been achieved by inserting a δ-doping sheet in the source region which leads to high drain current as compared to CG-TFET. The effect of distance between the δ-doping sheet and source/channel interface on the current performance, sub-threshold swing (SS) and threshold voltage (Vth) has been examined. The instantaneous position of δ-doping region from the tunneling junction is optimized based on the trade-off between current ratio and SS. The present model exhibit maximum switching current ratio (ION/IOFF ≅1012) for an optimum distance of 2 nm without degrading SS (SS∼55 mV/decade) and Vth performance. The electrostatic behavior of the present model is obtained using the solution of Poisson's equation in the cylindrical coordinate system. However the impact of scaling of the gate oxide thickness and cylindrical pillar diameter on drain current performance has been discussed. In future, DCG-TFET can be one of the potential successors for ultra-low-power applications because of its improved drain current and switching ratio.

  8. Subcritical transition to turbulence of a precessing flow in a cylindrical vessel

    Science.gov (United States)

    Herault, Johann; Gundrum, Thomas; Giesecke, André; Stefani, Frank

    2015-12-01

    The transition to turbulence in a precessing cylindrical vessel is experimentally investigated. Our measurements are performed for a nearly resonant configuration with an initially laminar flow dominated by an inertial mode with azimuthal wave number m = 1 superimposed on a solid body rotation. By increasing the precession ratio, we observe a transition from the laminar to a non-linear regime, which then breakdowns to turbulence for larger precession ratio. Our measurements show that the transition to turbulence is subcritical, with a discontinuity of the wall-pressure and the power consumption at the threshold ɛLT. The turbulence is self-sustained below this threshold, describing a bifurcation diagram with a hysteresis. In this range of the control parameters, the turbulent flows can suddenly collapse after a finite duration, leading to a definitive relaminarization of the flow. The average lifetime of the turbulence increases rapidly when ɛ tends to ɛLT.

  9. Subcritical transition to turbulence of a precessing flow in a cylindrical vessel

    CERN Document Server

    Herault, Johann; Giesecke, Andre; Stefani, Frank

    2015-01-01

    The transition to turbulence in a precessing cylindrical vessel is experimentally investigated. Our measurements are performed for a { nearly-resonant} configuration with an initially laminar flow dominated by an inertial mode with azimuthal wave number $m=1$ superimposed on a solid body rotation. By increasing the precession ratio, we observe a transition from the laminar to a non-linear regime, which then breakdowns to turbulence for larger precession ratio. Our measurements show that the transition to turbulence is subcritical, with a discontinuity of the wall-pressure and the power consumption at the threshold $\\epsilon_{LT}$. The turbulence is self-sustained below this threshold, describing a bifurcation diagram with a hysteresis. In this range of the control parameters, the turbulent flows can suddenly collapse after a finite duration, leading to a definitive relaminarization of the flow. The average lifetime $\\langle \\tau \\rangle$ of the turbulence increases rapidly when $\\epsilon$ tends to $\\epsilon_{...

  10. Simulation of cylindrical cup drawing of AZ31 sheet metal with crystal plasticity finite element method

    Science.gov (United States)

    Tang, Weiqin; Li, Dayong; Zhang, Shaorui; Peng, Yinghong

    2013-12-01

    As a light-weight structural material, magnesium alloys show good potential in improving the fuel efficiency of vehicles and reducing CO2 emissions. However, it is well known that polycrystalline Mg alloys develop pronounced crystallographic texture and plastic anisotropy during rolling, which leads to earing phenomenon during deep drawing of the rolled sheets. It is vital to predict this phenomenon accurately for application of magnesium sheet metals. In the present study, a crystal plasticity model for AZ31 magnesium alloy that incorporates both slip and twinning is established. Then the crystal plasticity model is implemented in the commercial finite element software ABAQUS/Explicit through secondary development interface (VUMAT). Finally, the stamping process of a cylindrical cup is simulated using the developed crystal plasticity finite element model, and the predicting method is verified by comparing with experimental results from both earing profile and deformation texture.

  11. Simulated annealing for three-dimensional low-beta reduced MHD equilibria in cylindrical geometry

    CERN Document Server

    Furukawa, M

    2016-01-01

    Simulated annealing (SA) is applied for three-dimensional (3D) equilibrium calculation of ideal, low-beta reduced MHD in cylindrical geometry. The SA is based on the theory of Hamiltonian mechanics. The dynamical equation of the original system, low-beta reduced MHD in this study, is modified so that the energy changes monotonically while preserving the Casimir invariants in the artificial dynamics. An equilibrium of the system is given by an extremum of the energy, therefore SA can be used as a method for calculating ideal MHD equilibrium. Previous studies demonstrated that the SA succeeds to lead to various MHD equilibria in two dimensional rectangular domain. In this paper, the theory is applied to 3D equilibrium of ideal, low-beta reduced MHD. An example of equilibrium with magnetic islands, obtained as a lower energy state, is shown. Several versions of the artificial dynamics are developed that can effect smoothing.

  12. Anisotropy of the electron component in a cylindrical magnetron discharge. I. Theory of the multiterm analysis.

    Science.gov (United States)

    Porokhova, I A; Golubovskii, Yu B; Behnke, J F

    2005-06-01

    A general multiterm representation of the phase space electron distribution function in terms of spherical tensors is used to solve the Boltzmann kinetic equation in crossed electric and magnetic fields. The problem is formulated for an axisymmetric cylindrical magnetron discharge with the homogeneous magnetic field being directed axially and the electric field between the coaxial cathode and anode varying in radius only. A spherical harmonic representation of the velocity distribution function in Cartesian coordinates becomes especially cumbersome in the presence of the magnetic field. In contrast, the employment of a spherical tensor representation leads to a compact hierarchy of equations that accurately take into account the spatial inhomogeneities and anisotropy of the plasma in crossed fields. To describe the spatially inhomogeneous plasma the hierarchy of the kinetic equations is formulated in terms of the total energy and the radial coordinate. Appropriate boundary conditions at the electrodes for the tensor expansion coefficients are obtained.

  13. Multidimensional modal analysis of liquid nonlinear sloshing in right circular cylindrical tank

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The multidimensional modal theory proposed by Faltinsen, et al. (2000) is applied to solve liquid nonlinear free sloshing in right circular cylindrical tank for the first time. After selecting the leading modes and fixing the order of magnitudes based on the Narimanov-Moiseev third order asymptotic hypothesis, the general infinite dimensional modal system is reduced to a five dimensional asymptotic modal system (the system of second order nonlinear ordinary differential equations coupling the generalized time dependent coordinates of free surface wave elevation). The numerical integrations of this modal system discover most important nonlinear phenomena, which agree well with both pervious analytic theories and experimental observations. The results indicate that the multidimensional modal method is a very good tool for solving liquid nonlinear sloshing dynamics and will be developed to investigate more complex sloshing problem in our following work.

  14. Fast magnetoacoustic wave trains of sausage symmetry in cylindrical waveguides of the solar corona

    CERN Document Server

    Shestov, S; Kuzin, S

    2015-01-01

    Fast magnetoacoustic waves guided along the magnetic field by plasma non-uniformities, in particular coronal loops, fibrils and plumes, are known to be highly dispersive, which leads to the formation of quasi-periodic wave trains excited by a broadband impulsive driver, e.g. a solar flare. We investigated effects of cylindrical geometry on the fast sausage wave train formation. We performed magnetohydrodynamic numerical simulations of fast magnetoacoustic perturbations of a sausage symmetry, propagating from a localised impulsive source along a field-aligned plasma cylinder with a smooth radial profile of the fast speed. The wave trains are found to have pronounced period modulation, with the longer instant period seen in the beginning of the wave train. The wave trains have also a pronounced amplitude modulation. Wavelet spectra of the wave trains have characteristic tadpole features, with the broadband large-amplitude heads preceding low-amplitude quasi-monochromatic tails. The mean period of the wave train...

  15. The nonlinear propagation of acoustic waves in a viscoelastic medium containing cylindrical micropores

    Institute of Scientific and Technical Information of China (English)

    Feng Yu-Lin; Liu Xiao-Zhou; Liu Jie-Hui; Ma Li

    2009-01-01

    Based on an equivalent medium approach,this paper presents a model describing the nonlinear propagation of acoustic waves in a viscoelastic medium containing cylindrical micropores. The influences of pores' nonlinear oscillations on sound attenuation,sound dispersion and an equivalent acoustic nonlinearity parameter are discussed. The calculated results show that the attenuation increases with an increasing volume fraction of mieropores. The peak of sound velocity and attenuation occurs at the resonant frequency of the micropores while the peak of the equivalent acoustic nonlinearity parameter occurs at the half of the resonant frequency of the micropores. Furthermore,multiple scattering has been taken into account,which leads to a modification to the effective wave number in the equivalent medium approach. We find that these linear and nonlinear acoustic parameters need to be corrected when the volume fraction of micropores is larger than 0.1%.

  16. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance.

    Science.gov (United States)

    Bonifaz, Laura; Bonnyay, David; Mahnke, Karsten; Rivera, Miguel; Nussenzweig, Michel C; Steinman, Ralph M

    2002-12-16

    To identify endocytic receptors that allow dendritic cells (DCs) to capture and present antigens on major histocompatibility complex (MHC) class I products in vivo, we evaluated DEC-205, which is abundant on DCs in lymphoid tissues. Ovalbumin (OVA) protein, when chemically coupled to monoclonal alphaDEC-205 antibody, was presented by CD11c+ lymph node DCs, but not by CD11c- cells, to OVA-specific, CD4+ and CD8+ T cells. Receptor-mediated presentation was at least 400 times more efficient than unconjugated OVA and, for MHC class I, the DCs had to express transporter of antigenic peptides (TAP) transporters. When alphaDEC-205:OVA was injected subcutaneously, OVA protein was identified over a 4-48 h period in DCs, primarily in the lymph nodes draining the injection site. In vivo, the OVA protein was selectively presented by DCs to TCR transgenic CD8+ cells, again at least 400 times more effectively than soluble OVA and in a TAP-dependent fashion. Targeting of alphaDEC-205:OVA to DCs in the steady state initially induced 4-7 cycles of T cell division, but the T cells were then deleted and the mice became specifically unresponsive to rechallenge with OVA in complete Freund's adjuvant. In contrast, simultaneous delivery of a DC maturation stimulus via CD40, together with alphaDEC-205:OVA, induced strong immunity. The CD8+ T cells responding in the presence of agonistic alphaCD40 antibody produced large amounts of interleukin 2 and interferon gamma, acquired cytolytic function in vivo, emigrated in large numbers to the lung, and responded vigorously to OVA rechallenge. Therefore, DEC-205 provides an efficient receptor-based mechanism for DCs to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after DC maturation.

  17. Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

    Science.gov (United States)

    Bonifaz, Laura; Bonnyay, David; Mahnke, Karsten; Rivera, Miguel; Nussenzweig, Michel C.; Steinman, Ralph M.

    2002-01-01

    To identify endocytic receptors that allow dendritic cells (DCs) to capture and present antigens on major histocompatibility complex (MHC) class I products in vivo, we evaluated DEC-205, which is abundant on DCs in lymphoid tissues. Ovalbumin (OVA) protein, when chemically coupled to monoclonal αDEC-205 antibody, was presented by CD11c+ lymph node DCs, but not by CD11c− cells, to OVA-specific, CD4+ and CD8+ T cells. Receptor-mediated presentation was at least 400 times more efficient than unconjugated OVA and, for MHC class I, the DCs had to express transporter of antigenic peptides (TAP) transporters. When αDEC-205:OVA was injected subcutaneously, OVA protein was identified over a 4–48 h period in DCs, primarily in the lymph nodes draining the injection site. In vivo, the OVA protein was selectively presented by DCs to TCR transgenic CD8+ cells, again at least 400 times more effectively than soluble OVA and in a TAP-dependent fashion. Targeting of αDEC-205:OVA to DCs in the steady state initially induced 4–7 cycles of T cell division, but the T cells were then deleted and the mice became specifically unresponsive to rechallenge with OVA in complete Freund's adjuvant. In contrast, simultaneous delivery of a DC maturation stimulus via CD40, together with αDEC-205:OVA, induced strong immunity. The CD8+ T cells responding in the presence of agonistic αCD40 antibody produced large amounts of interleukin 2 and interferon γ, acquired cytolytic function in vivo, emigrated in large numbers to the lung, and responded vigorously to OVA rechallenge. Therefore, DEC-205 provides an efficient receptor-based mechanism for DCs to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after DC maturation. PMID:12486105

  18. Production Target Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dale, Gregory E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Olivas, Eric Richard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-07-28

    The Northstar 99Mo production target, a cylindrical length of 100Mo rod, has evolved considerably since its first conception.  The cylinder was very early sliced into disks to increase the heat transfer area, first to 1 mm thick disks then to the current 0.5 mm thick.  The coolant was changed early in the target development from water to helium to eliminate corrosion and dissolution.  The diameter has increased from initially 6 mm to 12 mm, the current diameter of the test target now at ANL, to nominally 28 mm (26-30.6 mm, depending upon optimal beam spot size and shape).  The length has also changed to improve the production to cost ratio, so now the target is nominally 41 mm long (excluding coolant gaps between disks), and irradiated on both ends.  This report summarizes the current status of the plant target design.

  19. The analysis of the bending stiffness and intensity of cylindrical tubes

    Institute of Scientific and Technical Information of China (English)

    SONG YuQuan; GUAN ZhiPing; NIE YuQin; GUAN XiaoFang

    2007-01-01

    Based on the mechanics of material, the bending stiffness and intensity of cylindrical bar and tube are analyzed. By comparing the cylindrical tube whose ratio of outside diameter to internal diameter is 0.7 with the cylindrical bar, it is concluded that when both of them have the same mass, the section stiffness of the cylindrical tube is three times that of the cylindrical bar; when both of them have the same external diameter, the mass of the cylindrical tube is only 1/2 that of the cylindrical bar, but the section stiffness of the cylindrical tube is 3/4 that of the cylindrical bar.By virtue of the elemental elastic-plastic theory, the yield stress of the liquid-filled cylindrical tube is investigated. Due to the incompressibility of liquid and the strain hardening effect of material, the yield stress of the liquid-filled tube is enlarged compared with the hollow tube, thus raising its bending intensity. Under the dynamic load, compared with the hollow tube, the impact resistance of the liquid-filled tube is also raised due to elastic recovery. Because the hydraulic pressures perpendicular to the inner surface are identical everywhere, the local stress concentration resulting from the ovalisation of the tube would be decreased, and the resistance to buckling would be improved.

  20. The analysis of the bending stiffness and intensity of cylindrical tubes

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Based on the mechanics of material,the bending stiffness and intensity of cylin-drical bar and tube are analyzed. By comparing the cylindrical tube whose ratio of outside diameter to internal diameter is 0.7 with the cylindrical bar,it is concluded that when both of them have the same mass,the section stiffness of the cylindrical tube is three times that of the cylindrical bar;when both of them have the same external diameter,the mass of the cylindrical tube is only 1/2 that of the cylindrical bar,but the section stiffness of the cylindrical tube is 3/4 that of the cylindrical bar. By virtue of the elemental elastic-plastic theory,the yield stress of the liquid-filled cylindrical tube is investigated. Due to the incompressibility of liquid and the strain hardening effect of material,the yield stress of the liquid-filled tube is enlarged compared with the hollow tube,thus raising its bending intensity. Under the dy-namic load,compared with the hollow tube,the impact resistance of the liquid-filled tube is also raised due to elastic recovery. Because the hydraulic pressures per-pendicular to the inner surface are identical everywhere,the local stress concen-tration resulting from the ovalisation of the tube would be decreased,and the re-sistance to buckling would be improved.

  1. Three-step cylindrical seal for high-performance turbomachines

    Science.gov (United States)

    Hendricks, Robert C.

    1987-01-01

    A three-step cylindrical seal configuration representing the seal for a high performance turbopump (e.g., the space shuttle main engine fuel pump) was tested under static (nonrotating) conditions. The test data included critical mass flux and pressure profiles over a wide range of inlet temperatures and pressures for fluid nitrogen and fluid hydrogen with the seal in concentric and fully eccentric positions. The critical mass flux (leakage rate) was 70% that of an equivalent straight cylindrical seal with a correspondingly higher pressure drop based on the same flow areas of 0.3569 sq cm but 85% that of the straight seal based on the third-step flow area of 0.3044 sq cm. The mass flow rates for the three step cylindrical seal in the fully eccentric and concentric positions were essentially the same, and the trends in flow coefficient followed those of a simple axisymmetric inlet configuration. However, for inlet stagnation temperatures less than the thermodynamic critical temperature the pressure profiles exhibited a flat region throughout the third step of the seal, with the pressure magnitude dependent on the inlet stagnation temperature. Such profiles represent an extreme positive direct stiffness. These conditions engendered a crossover in the pressure profile upstream of the postulated choke that resulted in a local negative stiffness. Flat and crossover profiles resulting from choking within the seal are practically unknown to the seal designer. However, they are of critical importance to turbomachine stability and must be integrated into any dynamic analysis of a seal of this configuration. In addition, choking is highly dependent on geometry, inlet-to-backpressure ratio, and inlet temperature and can occur within the seal even though the backpressure is above the critical pressure.

  2. Interaction of cylindrically converging diffracted shock with uniform interface

    Science.gov (United States)

    Liang, Yu; Ding, Juchun; Zhai, Zhigang; Si, Ting; Luo, Xisheng

    2017-08-01

    The Richtmyer-Meshkov instability of an unperturbed air/SF6 interface subjected to a diffracted shock is experimentally studied by high-speed schlieren photography under cylindrical circumstances. The cylindrically converging diffracted shock (CCDS) is produced by a cylindrically uniform shock diffracting around a rigid cylinder(s), and the unperturbed interface is created by a soap film technique. The effects of coupling of multiple rigid cylinders and diverse spacings from the cylinder to interface on a flow field are highlighted. Schlieren images indicate that the amplitude of disturbances on the CCDS increases compared with the local shock radius. After the CCDS impact, a bulge is derived from the interface due to the shock-shock interaction inside the interface, and the number of bulges depends upon the number of cylinders. As the number of cylinders increases, the bulge becomes less pronounced, which is ascribed to additional shock-shock interactions inside the volume. As the distance between the cylinder and interface increases, an air cavity is first observed before the formation of a bulge. The amplitude of perturbation on the interface is found to reduce before the central reflected shock arrival because of the Rayleigh-Taylor stabilization effect. Through equating the pre-interface disturbance of the CCDS to the pre-shock perturbation of the perturbed interface, the initially linear growth rate is theoretically computed based on the impulsive model considering the Bell-Plesset effect. The theoretical results are found to deviate greatly from the experimental counterparts. Instead, taking the post-shock interface amplitude as an initial interface amplitude, the model works well. Therefore, the interface perturbations produced are notably smaller than the disturbances causing them. Moreover, the nonlinear behavior of perturbation growth is estimated by the model considering the Rayleigh-Taylor effect.

  3. Finite-amplitude waves in cylindrical lined ducts

    Science.gov (United States)

    Nayfeh, A. H.; Tsai, M.-S.

    1974-01-01

    A second-order uniformly valid expansion is obtained for nonlinear waves propagating in a cylindrical duct lined with a point-reacting acoustic material that consists of a porous sheet followed by honey-comb cavities and backed by the impervious walls of the duct. The effect of the liner is taken into account by coupling the waves in the duct with those in the liner. As in the two-dimensional case, the nonlinearity increases the attenuation rate at all frequencies except in narrow bandwidths around the resonant frequencies, irrespective of the geometrical dimensions of the liner or the acoustic properties of the porous sheet.

  4. PERFORATION OF PLASTIC SPHERICAL SHELLS UNDER IMPACT BY CYLINDRICAL PROJECTILES

    Institute of Scientific and Technical Information of China (English)

    NING Jian-guo; SONG Wei-dong

    2006-01-01

    The objective is to study the perforation of a plastic spherical shell impacted by a cylindrical projectile. First, the deformation modes of the shell were given by introducing an isometric transformation. Then, the perforation mechanism of the shell was analyzed and an analytical model was advanced. Based on Hamilton principle, the governing equation was obtained and solved using Runge-Kuta method. Finally, some important theoretical predictions were given to describe the perforation mechanism of the shell. The results will play an important role in understanding the perforation mechanism of spherical shells impacted by a projectile.

  5. Metamaterial Structure Design Optimization: A Study of the Cylindrical Cloak

    Science.gov (United States)

    2013-03-01

    energy. iv First, I wish to thank God and my savior, Jesus Christ , for the opportunity to study His creation. Next, a big thank-you goes to my loving wife...requirements to create a more physically realizable set of material parameters. 6 2.1 TO Cylindrical Cloak Originally , TO was conceived in an effort to avoid...TO method to designing a cloak consists of deforming the coordinate system such that the origin point is expanded into a boundary around an area to be

  6. Polar POLICRYPS diffractive structures generate cylindrical vector beams

    Energy Technology Data Exchange (ETDEWEB)

    Alj, Domenico; Caputo, Roberto, E-mail: roberto.caputo@fis.unical.it; Umeton, Cesare [Department of Physics and CNR-NANOTEC University of Calabria, I-87036 Rende (CS) (Italy); Paladugu, Sathyanarayana [Soft Matter Lab, Department of Physics, Bilkent University, Ankara 06800 (Turkey); Volpe, Giovanni [Soft Matter Lab, Department of Physics, Bilkent University, Ankara 06800 (Turkey); UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800 (Turkey)

    2015-11-16

    Local shaping of the polarization state of a light beam is appealing for a number of applications. This can be achieved by employing devices containing birefringent materials. In this article, we present one such enables converting a uniformly circularly polarized beam into a cylindrical vector beam (CVB). This device has been fabricated by exploiting the POLICRYPS (POlymer-LIquid CRYstals-Polymer-Slices) photocuring technique. It is a liquid-crystal-based optical diffraction grating featuring polar symmetry of the director alignment. We have characterized the resulting CVB profile and polarization for the cases of left and right circularly polarized incoming beams.

  7. DYNAMICAL BEHAVIOR OF VISCOELASTIC CYLINDRICAL SHELLS UNDER AXIAL PRESSURES

    Institute of Scientific and Technical Information of China (English)

    程昌钧; 张能辉

    2001-01-01

    The hypotheses of the Kármán-Donnell theory of thin shells with large deflections and the Boltzmann laws for isotropic linear, viscoelastic materials, the constitutive equations of shallow shells are first derived. Then the governing equations for the deflection equations of elastic thin plates. Introducing proper assumptions, an approximate theory for viscoelastic cylindrical shells under axial pressures can be obtained. Finally, the dynamical behavior is studied in detail by using several numerical methods. Dynamical properties,such as, hyperchaos , chaos, strange attractor, limit cycle etc., are discovered.

  8. Colliding wall-jets on a cylindrical surface

    Science.gov (United States)

    Tesař, Václav; Peszynski, Kazimierz

    2015-05-01

    Paper discusses aerodynamics and potential engineering applications of an unusual and in literature practically unknown fluid flow configuration, with two wall-jets attached to a cylindrical surface so that they collide head-on and by mutual conjunction generate a single jet directed away from the wall. Applications are envisaged in pneumatic sensors, particularly those operating at low Reynolds numbers. Performed experimental investigation, combined with numerical flowfield computations, revealed several interesting aspects. The most interesting among them is the discovery of symmetry-breaking existence of three different stable flow regimes. This opens a possibility for fluidic tristable amplifiers and systems operating with ternary logic.

  9. Cylindrical Three-Dimensional Porous Anodic Alumina Networks

    Directory of Open Access Journals (Sweden)

    Pedro M. Resende

    2016-11-01

    Full Text Available The synthesis of a conformal three-dimensional nanostructure based on porous anodic alumina with transversal nanopores on wires is herein presented. The resulting three-dimensional network exhibits the same nanostructure as that obtained on planar geometries, but with a macroscopic cylindrical geometry. The morphological analysis of the nanostructure revealed the effects of the initial defects on the aluminum surface and the mechanical strains on the integrity of the three-dimensional network. The results evidence the feasibility of obtaining 3D porous anodic alumina on non-planar aluminum substrates.

  10. Experimental comparison of symmetry in rugby and cylindrical holhraums

    Science.gov (United States)

    Philippe, Franck; Tassin, Veronique; Laffite, Stephane; Monteil, Marie-Christine; Bastian, Josiane; Lours, Laurence; Villette, Bruno; Stemmler, Philippe; Bednarczyk, Sophie; Reneaume, Benoit; di Nicola, Pascale; Raffin, Vincent

    2007-11-01

    Recently, holhraum shape optimization has been investigated as a practical way to achieve ignition at lower energy [1][2]. Rugby shaped holhraums theoretically allow better energetic coupling and symmetry control than classical cylinders. As a first step toward an experimental validation of this design, this talk presents the results of experiments on the OMEGA laser facility dedicated to the comparison of symmetry in cylindrical and rugby holhraums. Foamball radiographs and Symcaps emission contours for both type of holhraums are compared to numerical simulation results. [1] M. Vandenboomgaerde et al., accepted by Phys. Rev. Lett. [2] P. Amendt et al., Phys. Plasmas 14, 056312 (2007)

  11. Phase transition properties of a cylindrical ferroelectric nanowire

    Indian Academy of Sciences (India)

    Wang Ying; Yang Xiong

    2013-11-01

    Based on the transverse Ising model (TIM) and using the mean-field theory, we investigate the phase transition properties of a cylindrical ferroelectric nanowire. Two different kinds of phase diagrams are constructed. We discuss systematically the effects of exchange interactions and the transverse field parameters on the phase diagrams. Moreover, the cross-over features of the parameters from the ferroelectric dominant phase diagram to the paraelectric dominant phase diagram are determined for the ferroelectric nanowire. In addition, the polarizations of the surface shell and the core are illustrated in detail by modifying the TIM parameters.

  12. PCM thermal energy storage in cylindrical containers of various configurations

    Science.gov (United States)

    Mujumdar, A. S.; Ashraf, F. A.; Menon, A. S.; Weber, M. E.

    Experimental measurements are reported for the time variation of surface-averaged rate of heat storage during melting in single, thin-walled cylindrical containers of copper filled with a commercially available paraffin wax. For the wax used the enthalpy-temperature curve was obtained using a differential scanning calorimeter according to the ASTM method. Three lengths and three equivalent diameters of plain circular, plain square and internally partitioned cylinders were studied for their heat storage characteristics. The heat transfer measurements revealed the importance of natural convection during melting. The effects of cylinder geometry and temperature of the external fluid on instantaneous and integral heat storage rate were examined experimentally.

  13. Experimental Investigations of Compressed Sandwich Composite/Honeycomb Cylindrical Shells

    Science.gov (United States)

    Muc, A.; Stawiarski, A.; Romanowicz, P.

    2017-06-01

    This article explains in some details the behaviour of thick, deep cylindrical sandwich panels subjected to compressive loads. In general, experimental results indicated that two different forms of failure have been observed - the first corresponds to the overall buckling and the second to the facesheet wrinkling. The obtained experimentally damages of shells are verified and validated with the use of the FE analysis, 2-D and 3-D both in the linear and non-linear approach. The unidirectional strain gauges were applied to detect the initiation of the overall buckling mode.

  14. Three-dimensional global fluid simulations of cylindrical magnetized plasmas

    DEFF Research Database (Denmark)

    Naulin, Volker; Windisch, T.; Grulke, O.

    2008-01-01

    . Thus, it is possible to assess the reproductive and predictive capabilities of plasma simulations in unprecedented detail. Here, three-dimensional global fluid simulations of a cylindrical magnetized plasma are presented. This plasma is characterized by the existence of spatially localized sources...... and sinks. The traditional scale separation paradigm is not applied in the simulation model to account for the important evolution of the background profiles due to the dynamics of turbulent fluctuations. Furthermore, the fluid modeling of sheath boundary conditions, which determine the plasma conditions...

  15. Preliminary analysis techniques for ring and stringer stiffened cylindrical shells

    Science.gov (United States)

    Graham, J.

    1993-03-01

    This report outlines methods of analysis for the buckling of thin-walled circumferentially and longitudinally stiffened cylindrical shells. Methods of analysis for the various failure modes are presented in one cohesive package. Where applicable, more than one method of analysis for a failure mode is presented along with standard practices. The results of this report are primarily intended for use in launch vehicle design in the elastic range. A Microsoft Excel worksheet with accompanying macros has been developed to automate the analysis procedures.

  16. Radiation from a charge rotating inside a cylindrical grating

    Science.gov (United States)

    Kotanjyan, A. S.; Mkrtchyan, A. R.; Saharian, A. A.

    2017-07-01

    We investigate the spectral-angular distribution for the radiation emitted by a point charge moving along a helical trajectory inside a cylindrical grating with conducting strips. Two types of the radiation processes are realized: undulator and Smith-Purcell radiations. Their relative contributions to the total radiation intensity are discussed in various asymptotic regions of the parameters describing the diffraction grating and for large harmonics. The region of the parameters is specified for which the interference effects between the undulator and Smith-Purcell radiations are essential.

  17. The hydrodynamic instability of powerful cylindrical magnetohydrodynamic pumps

    Energy Technology Data Exchange (ETDEWEB)

    Valdmane, R.A.; Ulmanis, L.Ya.; Valdamanis, Ya.Ya.

    1984-01-01

    A numerical calculation is the basis for analyzing the issues of stability of the speed profile in channels of powerful cylindrical magnetohydrodynamic (MGD) pumps. A one dimensional hydraulic model is used in the calculations. The questions about stability of movement relative to transverse perturbations in speed are discussed. It is shown that at high values of the parameter epsilon and the radius of the channel the movement is unstable with respect to the transverse shifts. The results are of interest for studies of liquid metal magnetohydrodynamic generators.

  18. Finite Amplitude Electron Plasma Waves in a Cylindrical Waveguide

    DEFF Research Database (Denmark)

    Juul Rasmussen, Jens

    1978-01-01

    The nonlinear behaviour of the electron plasma wave propagating in a cylindrical plasma waveguide immersed in an infinite axial magnetic field is investigated using the Krylov-Bogoliubov-Mitropolsky perturbation method, by means of which is deduced the nonlinear Schrodinger equation governing...... the long-time slow modulation of the wave amplitude. From this equation the amplitude-dependent frequency and wavenumber shifts are calculated, and it is found that the electron waves with short wavelengths are modulationally unstable with respect to long-wavelength, low-frequency perturbations...

  19. Well-posedness of a model for structural acoustic coupling in a cavity enclosed by a thin cylindrical shell

    Science.gov (United States)

    Banks, H. T.; Smith, R. C.

    1993-01-01

    A fully coupled mathematical model describing the interactions between a vibrating thin cylindrical shell and enclosed acoustic field is presented. Because the model will ultimately be used in control applications involving piezoceramic actuators, the loads and material contributions resulting from piezoceramic patches bonded to the shell are included in the discussion. Theoretical and computational issues lead to the consideration of a weak form of the modeling set of partial differential equations (PDE's) and through the use of a semigroup formulation, well-posedness results for the system model are obtained.

  20. Current issues in human lead exposure and regulation of lead.

    Science.gov (United States)

    Davis, J M; Elias, R W; Grant, L D

    1993-01-01

    Concern about lead as a significant public health problem has increased as epidemiological and experimental evidence has mounted regarding adverse health effects at successively lower levels of lead exposure. This concern has led to downward revision of criteria for acceptable blood lead concentrations to the 10 micrograms/dL mark now designated by EPA as a target level for regulatory development and enforcement/clean-up purposes. Much progress has been made in reducing lead exposures during the past 10-15 years, with marked declines evident both in air lead and blood lead concentrations in parallel to the phase-down of lead in gasoline and notable decreases in food lead exposure due to elimination of lead soldered cans by U.S. food processors. With the lessening of exposure from these sources, the importance of other components of multimedia exposure pathways has grown and stimulated increasing regulatory attention and abatement efforts to reduce health risks associated with lead exposure from drinking water, from lead-based paint, and from household dust and soil contaminated by deteriorating paint, smelter emissions, or various other sources. Increasing attention is also being accorded to reduction of occupational lead exposures (including those related to lead abatement activities), with particular concern for protection of men and women during their reproductive years.

  1. Robotic radiosurgery system patient-specific QA for extracranial treatments using the planar ion chamber array and the cylindrical diode array.

    Science.gov (United States)

    Lin, Mu-Han; Veltchev, Iavor; Koren, Sion; Ma, Charlie; Li, Jinsgeng

    2015-07-08

    Robotic radiosurgery system has been increasingly employed for extracranial treatments. This work is aimed to study the feasibility of a cylindrical diode array and a planar ion chamber array for patient-specific QA with this robotic radiosurgery system and compare their performance. Fiducial markers were implanted in both systems to enable image-based setup. An in-house program was developed to postprocess the movie file of the measurements and apply the beam-by-beam angular corrections for both systems. The impact of noncoplanar delivery was then assessed by evaluating the angles created by the incident beams with respect to the two detector arrangements and cross-comparing the planned dose distribution to the measured ones with/without the angular corrections. The sensitivity of detecting the translational (1-3 mm) and the rotational (1°-3°) delivery errors were also evaluated for both systems. Six extracranial patient plans (PTV 7-137 cm³) were measured with these two systems and compared with the calculated doses. The plan dose distributions were calculated with ray-tracing and the Monte Carlo (MC) method, respectively. With 0.8 by 0.8 mm² diodes, the output factors measured with the cylindrical diode array agree better with the commissioning data. The maximum angular correction for a given beam is 8.2% for the planar ion chamber array and 2.4% for the cylindrical diode array. The two systems demonstrate a comparable sensitivity of detecting the translational targeting errors, while the cylindrical diode array is more sensitive to the rotational targeting error. The MC method is necessary for dose calculations in the cylindrical diode array phantom because the ray-tracing algorithm fails to handle the high-Z diodes and the acrylic phantom. For all the patient plans, the cylindrical diode array/ planar ion chamber array demonstrate 100% / > 92% (3%/3 mm) and > 96% / ~ 80% (2%/2 mm) passing rates. The feasibility of using both systems for robotic

  2. Superconductivity and mesoscopic physics in planar and cylindrical films of gold-indium alloy

    Science.gov (United States)

    Zadorozhny, Yuri Kostyantinovich

    Superconducting properties of planar and cylindrical thin films of Au 0.7In0.3 alloy have been investigated by electrical transport measurements at low temperature and in the presence of applied magnetic field. The films were grown on flat substrates and on insulating fibers of sub-micron diameter, respectively, by sequential deposition and interdiffusion of alternating gold and indium layers. The primary focus of the study was the effects of disorder, sample size, sample topology, and quantum interferences on the superconducting properties of these samples. Structural and compositional analysis and transport measurements were carried out, which showed that the films were granular, with varying local indium concentrations, apparently corresponding to several distinct alloy phases. This variation, in turn, led to the variation in the local amplitude of the superconducting order parameter, and in the local superconducting transition temperature (Tc). In planar films, the presence of disorder in the sample leads to a broad superconducting transition regime, typically with a gradual resistance drop at the onset of the transition, followed by a more abrupt one as the temperature is lowered. At the lowest temperatures in transition regime, deviations from the behavior expected in Kosterlitz-Thouless-Berezinskii (KTB) vortex-antivortex pair unbinding model were found in the I-V characteristics of the films. This deviation could originate from vortex-antivortex pair unbinding by quantum tunneling rather than thermal activation. Magnetoresistance oscillations in cylindrical Au0.7In 0.3 films at low temperatures were also studied. In the high-temperature part of the superconducting transition regime, the resistance oscillated with a period of h/2e in the unit of the enclosed magnetic flux, as expected for Little-Parks effect. Unlike the cylindrical samples discussed above, which were mechanically and thermally anchored, superconducting Au0.7In0.3 cylinders used in the early

  3. Down-Regulation of miR-129-5p and the let-7 Family in Neuroendocrine Tumors and Metastases Leads to Up-Regulation of Their Targets Egr1, G3bp1, Hmga2 and Bach1

    DEFF Research Database (Denmark)

    Dossing, Kristina B. V.; Binderup, Tina; Kaczkowski, Bogumil

    2014-01-01

    by miR-129-5p. let-7 overexpression inhibited growth of carcinoid cell lines, and let-7 inhibition increased protein content of the transcription factor BACH1 and its targets MMP1 and HMGA2, all known to promote bone metastases. Immunohistochemistry analysis revealed that let-7 targets are highly...

  4. Liquid bridging of cylindrical colloids in near-critical solvents

    Science.gov (United States)

    Labbé-Laurent, M.; Law, A. D.; Dietrich, S.

    2017-09-01

    Within mean field theory, we investigate the bridging transition between a pair of parallel cylindrical colloids immersed in a binary liquid mixture as a solvent that is close to its critical consolute point Tc. We determine the universal scaling functions of the effective potential and of the force between the colloids. For a solvent that is at the critical concentration and close to Tc, we find that the critical Casimir force is the dominant interaction at close separations. This agrees very well with the corresponding Derjaguin approximation for the effective interaction between the two cylinders, while capillary forces originating from the extension of the liquid bridge turn out to be more important at large separations. In addition, we are able to infer from the wetting characteristics of the individual colloids the first-order transition of the liquid bridge connecting two colloidal particles to the ruptured state. While specific to cylindrical colloids, the results presented here also provide an outline for identifying critical Casimir forces acting on bridged colloidal particles as such and for analyzing the bridging transition between them.

  5. Cylindrical acoustical holography applied to full-scale jet noise.

    Science.gov (United States)

    Wall, Alan T; Gee, Kent L; Neilsen, Tracianne B; Krueger, David W; James, Michael M

    2014-09-01

    Near-field acoustical holography methods are used to predict sound radiation from an engine installed on a high-performance military fighter aircraft. Cylindrical holography techniques are an efficient approach to measure the large and complex sound fields produced by full-scale jets. It is shown that a ground-based, one-dimensional array of microphones can be used in conjunction with a cylindrical wave function field representation to provide a holographic reconstruction of the radiated sound field at low frequencies. In the current work, partial field decomposition methods and numerical extrapolation of data beyond the boundaries of the hologram aperture are required prior to holographic projection. Predicted jet noise source distributions and directionality are shown for four frequencies between 63 and 250 Hz. It is shown that the source distribution narrows and moves upstream, and that radiation directionality shifts toward the forward direction, with increasing frequency. A double-lobe feature of full-scale jet radiation is also demonstrated.

  6. Progress on Diamond-Based Cylindrical Dielectric Accelerating Structures

    Science.gov (United States)

    Kanareykin, A.; Schoessow, P.; Conde, M.; Gai, W.

    2006-11-01

    The development of a high gradient diamond-based cylindrical dielectric loaded accelerator (DLA) is presented. A diamond-loaded DLA can potentially sustain accelerating gradients far in excess of the limits experimentally observed for conventional metallic accelerating structures. The electrical and mechanical properties of diamond make it an ideal candidate material for use in dielectric accelerators: high rf breakdown level, extremely low dielectric losses and the highest available thermoconductive coefficient. We used the hot-filament Chemical Vapor Deposition (CVD) process to produce high quality 5-10 cm long cylindrical diamond layers. Our collaboration has also been developing a new method of CVD diamond surface preparation that reduces the secondary electron emission coefficient below unity. Special attention was paid to the numerical optimization of the waveguide to structure rf coupling section, where the surface magnetic and electric fields were minimized relative to the accelerating gradient and within known metal surface breakdown limits. We conclude with a brief overview of the use of diamond microstructures for use in compact rf sources.

  7. An Analytical Solution for Cylindrical Concrete Tank on Deformable Soil

    Directory of Open Access Journals (Sweden)

    Shirish Vichare

    2010-07-01

    Full Text Available Cylindrical concrete tanks are commonly used in wastewater treatment plants. These are usually clarifier tanks. Design codes of practice provide methods to calculate design forces in the wall and raft of such tanks. These methods neglect self-weight of tank material and assume extreme, namely ‘fixed’ and ‘hinged’ conditions for the wall bottom. However, when founded on deformable soil, the actual condition at the wall bottom is neither fixed nor hinged. Further, the self-weight of the tank wall does affect the design forces. Thus, it is required to offer better insight of the combined effect of deformable soil and bottom raft stiffness on the design forces induced in such cylindrical concrete tanks. A systematic analytical method based on fundamental equations of shells is presented in this paper. Important observations on variation of design forces across the wall and the raft with different soil conditions are given. Set of commonly used tanks, are analysed using equations developed in the paper and are appended at the end.

  8. Acoustic mode coupling of two facing, shallow cylindrical cavities

    Science.gov (United States)

    McCarthy, Philip; Ekmekci, Alis

    2016-11-01

    Cavity mode excitation by grazing flows is a well-documented source for noise generation. Similarly to their rectangular equivalents, single cylindrical cavities have been shown to exhibit velocity dependent self-sustaining feedback mechanisms that produce significant tonal noise. The present work investigates the effect of cavity mode coupling on the tonal noise generation for two facing, shallow cylindrical cavities. This geometric arrangement may occur for constrained flows, such as those within ducts, silencers or between aircraft landing gear wheels. For the latter configuration, the present study has observed that the tonal frequency dependence upon the freestream Mach number, associated with the single cavity feedback mechanism, no longer holds true. Instead, two simultaneously present and distinct large amplitude tones that are independent (in frequency) of speed, propagate to the far field. These two, fixed frequency tones are attributable to the first order transverse mode, and the first order transverse and azimuthal modes for the two combined cavities and the volume between them. Altering either the cavity aspect ratio or the inter-cavity spacing thus changes the acoustic resonant volume and translates the centre frequencies of the observed tones correspondingly. The authors would like to thank Bombardier and Messier-Bugatti-Dowty for their continued support.

  9. Local and Global Casimir Energies for a Semitransparent Cylindrical Shell

    CERN Document Server

    Cavero-Pelaez, I; Milton, K A; Cavero-Pelaez, Ines; Kirsten, Klaus; Milton, Kimball A.

    2006-01-01

    The local Casimir energy density and the global Casimir energy for a massless scalar field associated with a $\\lambda\\delta$-function potential in a 3+1 dimensional circular cylindrical geometry are considered. The global energy is examined for both weak and strong coupling, the latter being the well-studied Dirichlet cylinder case. For weak-coupling,in $\\mathcal{O}(\\lambda^2)$, the total energy is shown to vanish by both analytic and numerical arguments, based both on Green's-function and zeta-function techniques. Divergences occurring in the calculation are shown to be absorbable by renormalization of physical parameters of the model. The global energy may be obtained by integrating the local energy density only when the latter is supplemented by an energy term residing precisely on the surface of the cylinder. The latter is identified as the integrated local energy density of the cylindrical shell when the latter is physically expanded to have finite thickness. Inside and outside the shell, the local energ...

  10. Micro-photonic cylindrical waveguide based protein biosensor

    Energy Technology Data Exchange (ETDEWEB)

    Padigi, Sudhaprasanna Kumar [Department of Electrical and Computer Engineering, Portland State University, 160-11 FAB, 1900 SW Fourth Avenue, Portland, OR 97201 (United States); Asante, Kofi [Department of Physics, Portland State University, Portland, OR 97201 (United States); Kovvuri, Vijay Sekhar Reddy [Department of Electrical and Computer Engineering, Portland State University, 160-11 FAB, 1900 SW Fourth Avenue, Portland, OR 97201 (United States); Reddy, Ravi Kiran Kondama [Department of Electrical and Computer Engineering, Portland State University, 160-11 FAB, 1900 SW Fourth Avenue, Portland, OR 97201 (United States); Rosa, Andres La [Department of Physics, Portland State University, Portland, OR 97201 (United States); Prasad, Shalini [Department of Electrical and Computer Engineering, Portland State University, 160-11 FAB, 1900 SW Fourth Avenue, Portland, OR 97201 (United States)

    2006-09-14

    In this paper we experimentally demonstrate the fabrication and operation of a rapidly prototyped optical cylindrical micro-waveguide based biosensor. This device works on the principle of variation to the light intensity and path of coupled input light due to the binding of protein bio-molecules onto the micro-waveguide surface as a method of physical transduction. The variation to the coupled light intensity and path is dependent on the nature of the bio-molecule and the density of the bio-molecules. This technique has been used to identify protein biomarkers for inflammation and thrombosis, namely myeloperoxidase (MPO) and C-reactive protein (CRP). The detection limit that has been demonstrated is pg ml{sup -1}. The detection speed is of the order of seconds from the time of injection of the bio-molecule. The optical signature that is obtained to identify a protein bio-molecule is entirely dependent on the nature of adsorption of the bio-molecule on to the cylindrical cavity surfaces. This in turn is dependent on the protein conformation and the surface charge of the bio-molecules. Hence a specific protein bio-molecule generates a unique optical identifier based on the nature of binding/adsorption to the cavity surface. This physical phenomenon is exploited to identify individual proteins. This technique is a demonstration of detection of nano-scale protein bio-molecules using the optical biosensor technique with unprecedented sensitivity.

  11. Design of Slit between Micro Cylindrical Pillars for Cell Sorting

    Directory of Open Access Journals (Sweden)

    Yusuke Takahashi

    2016-12-01

    Full Text Available Micro slits have been designed between micro cylindrical pillars to sort biological cells. Micro cylindrical pillars of 0.02 mm diameter and 0.055 mm height were fabricated on the glass plate using the photolithography technique. Variation was made on the gap between pillars: 0.01 mm, 0.02 mm, 0.03 mm, and 0.04 mm. The micro pillars are set in the flow path between parallel plates, of which dimension of the cross section is 5 mm width and 0.055 mm height. Three kinds of biological cells were used in the test alternatively: C2C12 (mouse myoblast cell line originated with cross-striated muscle of C3H mouse, Hepa1-6 (mouse hepatoma cell line of C57L mouse, or swine red blood cell. The suspension of cells was introduced into the slits by the syringe pump at the flow rate between 0.4 and 500 cm3/hour. The deformation of the cell at the slit can be observed by the microscope. The experimental results show that the designed slit has capability for sorting cells according to the size and deformability of the cell.

  12. Array gain for a cylindrical array with baffle scatter effects.

    Science.gov (United States)

    Bertilone, Derek C; Killeen, Damien S; Bao, Chaoying

    2007-11-01

    Cylindrical arrays used in sonar for passive underwater surveillance often have sensors surrounding a cylindrical metal baffle. In some operational sonars, the phones in each stave (i.e., each line of phones aligned with the cylinder axis) are hardwired together so that the array is equivalent to a baffled circular array of directional elements, where each element corresponds to a line array of omnidirectional phones steered to broadside. In this paper a model is introduced for computing the array gain of such an array at high frequencies, which incorporates baffle scatter using infinite, rigid cylinder scattering theory, and with ambient noise described by an angular spectral density function. In practice the phones are often offset from the baffle surface, and the acoustic field sampled by the staves is distorted at high frequencies due to interference between the incident and scattered fields. Examples are given to illustrate the resulting array gain degradation, using three noise distributions that are frequently used in sonar performance modeling: three-dimensional isotropic, two-dimensional isotropic, and surface dipole noise.

  13. Finite deformations of an electroelastic circular cylindrical tube

    Science.gov (United States)

    Melnikov, Andrey; Ogden, Ray W.

    2016-12-01

    In this paper the theory of nonlinear electroelasticity is used to examine deformations of a pressurized thick-walled circular cylindrical tube of soft dielectric material with closed ends and compliant electrodes on its curved boundaries. Expressions for the dependence of the pressure and reduced axial load on the deformation and a potential difference between, or uniform surface charge distributions on, the electrodes are obtained in respect of a general isotropic electroelastic energy function. To illustrate the behaviour of the tube, specific forms of energy functions accounting for different mechanical properties coupled with a deformation independent quadratic dependence on the electric field are used for numerical purposes, for a given potential difference and separately for a given charge distribution. Numerical dependences of the non-dimensional pressure and reduced axial load on the deformation are obtained for the considered energy functions. Results are then given for the thin-walled approximation as a limiting case of a thick-walled cylindrical tube without restriction on the energy function. The theory described herein provides a general basis for the detailed analysis of the electroelastic response of tubular dielectric elastomer actuators, which is illustrated for a fixed axial load in the absence of internal pressure and fixed internal pressure in the absence of an applied axial load.

  14. Beam Switching Cylindrical Array Antenna System for Communication

    Directory of Open Access Journals (Sweden)

    V. C. Misra

    1998-10-01

    Full Text Available The beam switching cylindrical array, which is a unique system, has been designed and developed to cover 360° in azimuth plane by generating 16 beams with specified elevation coverage.In this design, the concept of fast aperture selection (4 x 4 in microseconds from the total cylindrical array has been realised successfully to meet the requirement of point-to-multipoint communication. The components of the array, viz., radiating elements, powder dividers, switches, etc., are designed in printed circuit type, and hence, objectives of lightweight and ease of reproducibility are achieved. The lightweight of the array makes it accessible for easy mounting at a specified height for achieving longer communication range. Finally, a low-loss radome is incorporated to protect the array from environmental conditions. The various parameters, viz., return loss, gain, and switched-beam radiation patterns were measured over a bandwidth of 300 MHz in L- band and typical measured results are presented in this paper.

  15. Nonlinear RF spurious in a cylindrical cavity with superconducting endplates

    Science.gov (United States)

    Mateu, Jordi; Collado, Carlos; Shaw, Timothy J.; O'Callaghan, Juan M.

    2002-08-01

    We have developed a method to calculate the distribution of fundamental and spurious fields in a metallic cylindrical cavity with superconducting endplates in which signals at two different frequencies are injected. The nonlinearity in the superconductor produces the typical intermodulation effects if the frequencies of the injected signals are sufficiently close to each other and near a resonant mode. Our method uses harmonic balance to match the fields in the cavity with the currents on the endplates. The method can be used for a variety of nonlinear models of the superconducting endplate, and could be the base for a nondestructive procedure to extract the nonlinear parameters of an HTS sample from RF measurements. Our analysis is restricted to the TE0 1 1 mode, but the method can be applied to any propagating mode in the cylindrical cavity. Closed-form equations for the case of square-law nonlinearities in the superconductor are derived and used to check the validity of the harmonic balance calculation.

  16. Unpolarized radiative cylindrical spacetimes Trapped surfaces and quasilocal energy

    CERN Document Server

    Gonçalves, S M C V

    2003-01-01

    We consider the most general vacuum cylindrical spacetimes, which are defined by two global, spacelike, commuting, non-hypersurface-orthogonal Killing vector fields. The cylindrical waves in such spacetimes contain both + and $\\times$ polarizations, and are thus said to be unpolarized. We show that there are no trapped cylinders in the spacetime, and present a formal derivation of Thorne's C-energy, based on a Hamiltonian reduction approach. Using the Brown-York quasilocal energy prescription, we compute the actual physical energy (per unit Killing length) of the system, which corresponds to the value of the Hamiltonian that generates unit proper-time translations orthogonal to a given fixed spatial boundary. The C-energy turns out to be a monotonic non-polynomial function of the Brown-York quasilocal energy. Finally, we show that the Brown-York energy at spatial infinity is related to an asymptotic deficit angle in exactly the same manner as the specific mass of a straight cosmic string is to the former.

  17. On Sector Magnets or Transverse Electromagnetic Fields in Cylindrical Coordinates

    Energy Technology Data Exchange (ETDEWEB)

    Zolkin, Timofey [Fermilab

    2016-03-10

    The Laplace's equations for the scalar and vector potentials describing electric or magnetic fields in cylindrical coordinates with translational invariance along azimuthal coordinate are considered. The series of special functions which, when expanded in power series in radial and vertical coordinates, in lowest order replicate the harmonic homogeneous polynomials of two variables are found. These functions are based on radial harmonics found by Edwin~M.~McMillan in his more-than-40-years "forgotten" article, which will be discussed. In addition to McMillan's harmonics, second family of adjoint radial harmonics is introduced, in order to provide symmetric description between electric and magnetic fields and to describe fields and potentials in terms of same special functions. Formulas to relate any transverse fields specified by the coefficients in the power series expansion in radial or vertical planes in cylindrical coordinates with the set of new functions are provided. This result is no doubt important for potential theory while also critical for theoretical studies, design and proper modeling of sector dipoles, combined function dipoles and any general sector element for accelerator physics. All results are presented in connection with these problems.

  18. Entropy generation analysis of cylindrical heat pipe using nanofluid

    Energy Technology Data Exchange (ETDEWEB)

    Ghanbarpour, Morteza, E-mail: morteza.ghanbarpour@energy.kth.se; Khodabandeh, Rahmatollah

    2015-06-20

    Highlights: • Entropy generation of heat pipe with nanofluid has been studied. • Nanofluid has significant effect on heat pipe performance. • Entropy generation in heat pipe decreases when nanofluids are used as working fluids. - Abstract: Thermal performance of cylindrical heat pipe with nanofluid is studied based on the laws of thermodynamics. The objective of the present work is to investigate nanofluids effect on different sources of entropy generation in heat pipe caused by heat transfer between hot and cold reservoirs and also frictional losses and pressure drop in the liquid and vapor flow along heat pipe. An analytical study was performed to formulate all sources of entropy generation and the predicted results are compared with experimental ones. Cylindrical miniature grooved heat pipes of 250 mm length and 6.35 mm outer diameter were fabricated and tested with distilled water and water based TiO{sub 2} and Al{sub 2}O{sub 3} nanofluids at different concentrations as working fluids. Analytical and experimental results revealed that the entropy generation in heat pipes decreases when nanofluids are used as working fluids instead of basefluid which results in improved thermal performance of the heat pipes with nanofluids.

  19. Vibration of in-vacuo elliptic cylindrical shells

    Science.gov (United States)

    Boisvert, Jeffrey E.; Hayek, Sabih I.

    2003-10-01

    The equations of motion for the vibration of elliptic cylindrical shells of constant thickness were derived using a Galerkin approach. The elastic strain energy density used in this derivation has seven independent kinematic variables: three displacements, two thickness-shear, and two thickness-stretch. The resulting seven coupled algebraic equations are symmetric and positive definite. The shell has a constant thickness, h, finite length, L, and is simply supported at its ends, (z=0,L), where z is the axial coordinate. The elliptic cross-section is defined by the shape parameter, a, and the half-length of the major axis, l. The modal solutions are expanded in a doubly infinite series of comparison functions in terms of circular functions in the angular and axial coordinates. The natural frequencies and the mode shapes were obtained by the Galerkin method. Numerical results were obtained for several h/l and L/l ratios, and various shape parameters, including the limiting case of a simply supported cylindrical shell (a=100). [Work supported by ONR and the Navy/ASEE Summer Faculty Program.

  20. Nonlinear Dynamic Buckling of Damaged Composite Cylindrical Shells

    Institute of Scientific and Technical Information of China (English)

    WANG Tian-lin; TANG Wen-yong; ZHANG Sheng-kun

    2007-01-01

    Based on the first order shear deformation theory(FSDT), the nonlinear dynamic equations involving transverse shear deformation and initial geometric imperfections were obtained by Hamilton's philosophy. Geometric deformation of the composite cylindrical shell was treated as the initial geometric imperfection in the dynamic equations, which were solved by the semi-analytical method in this paper. Stiffness reduction was employed for the damaged sub-layer, and the equivalent stiffness matrix was obtained for the delaminated area. By circumferential Fourier series expansions for shell displacements and loads and by using Galerkin technique, the nonlinear partial differential equations were transformed to ordinary differential equations which were finally solved by the finite difference method. The buckling was judged from shell responses by B-R criteria, and critical loads were then determined. The effect of the initial geometric deformation on the dynamic response and buckling of composite cylindrical shell was also discussed, as well as the effects of concomitant delamination and sub-layer matrix damages.