Biomedical research with cyclotron produced radionuclides. Progress report, October 1, 1977--September 30, 1978

International Nuclear Information System (INIS)

Laughlin, J.S.; Benua, R.S.; Tilbury, R.S.; Bigler, R.E.

1978-01-01

Progress is reported on biomedical studies using cyclotron-produced 18 F, 15 O, 11 C, 13 N, 52 Fe, 38 K, 206 Bi, 73 Se, 53 Co, and 43 K. The following research projects are described: tumor detection and diagnosis; neurological studies; radiopharmaceutical development; 38 K as an indicator of blood flow to the myocardium; dosimetry for internally deposited isotopes in animals and man; cyclotron development; positron tomographic imaging with the TOKIM System; and review of positron emission transaxial tomograph instruments

Standardized high current solid targets for cyclotron production of radionuclides

International Nuclear Information System (INIS)

Al-Jammaz, Ibrahim

2000-01-01

The Cyclotron and Radiopharmaceuticals Department (CRP) is an advanced and modern facility that encompasses two essential components: radioisotope research, and radiopharmaceuticals manufacturing. Radiopharmaceuticals manufacturing program is not only quite unique, but also an essential component of King Faisal Specialist Hospital and Research Center (KFSH and RC) in providing quality patient care for the population of the Kingdom. Accurate diagnosis and therapy with medical imaging equipment requires quality radiopharmaceuticals that are available readily and with reliability. The CRP Department provides that quality and reliability. Research activities of the CRP Department are focused on developing new radiotracers with potential usefulness in biomedical research and clinical applications. Research projects consist of: developing cyclotron targetry for radioisotope production; developing synthesis methods for radiolabeling biomolecules; and developing analytical methods for quality control. The CRP Department operates a semi-commercial radiopharmaceuticals manufacturing program that supplies the diagnostic radioactive products to several hospitals in the Kingdom and neighboring countries. These products for clinical applications are produced according to the international standards of Good Manufacturing Practices of quality and efficacy. At the heart of the radioisotope program is a medium energy cyclotron capable of accelerating a number of particles for transformation of non-radioactive atoms into radionuclides that are the primary sources for research and development activities, and for preparing radiopharmaceuticals. In addition to having the only cyclotron facility in the region, KFSH and RC also has the only Positron Emission Tomography Center (PET) in this part of the world. This combination of cyclotron and the ultra modern PET facility translates into advanced and specialized care for the patients at KFSH and RC

Biomedical research with cyclotron produced radionuclides. Progress report, October 1, 1977--September 30, 1978

Energy Technology Data Exchange (ETDEWEB)

Laughlin, J.S.; Benua, R.S.; Tilbury, R.S.; Bigler, R.E.

1978-09-30

Progress is reported on biomedical studies using cyclotron-produced /sup 18/F, /sup 15/O, /sup 11/C, /sup 13/N, /sup 52/Fe, /sup 38/K, /sup 206/Bi, /sup 73/Se, /sup 53/Co, and /sup 43/K. The following research projects are described: tumor detection and diagnosis; neurological studies; radiopharmaceutical development; /sup 38/K as an indicator of blood flow to the myocardium; dosimetry for internally deposited isotopes in animals and man; cyclotron development; positron tomographic imaging with the TOKIM System; and review of positron emission transaxial tomograph instruments. (HLW)

Biomedical cyclotron facility

International Nuclear Information System (INIS)

MacDonald, N.S.; Birdsall, R.; Takahaski, J.; McConnel, L.; Wood, R.; Wakakuwa, S.

1976-01-01

During the fifth year of operation the mechanical performance of the cyclotron and accessory equipment was excellent. Major items put into operation were a small computer system interfaced with Ge-Li gamma spectrometer and a pneumatic-tube system for fast delivery of short-lived radionuclides. A table is presented listing the radionuclides produced

The National Medical Cyclotron - An Australian experience in technology

International Nuclear Information System (INIS)

Barnes, R. K.

1997-01-01

The establishment of the National Medical Cyclotron (NMC) in the early 1990's was the practical outcome of a vision, held by nuclear medicine professionals, to complement the available neutron-rich radionuclides produced in Australia, with neutron-deficient radionuclides. The NMC is operated by the Australian Nuclear Science and Technology Organisation (ANSTO) in collaboration with the Royal Prince Alfred Hospital (RPAH) in Sydney where the PET department is able to use the short-lived radiotracers to good advantage. Neutron-deficient radionuclides, are also produced by the NMC laboratories. The cyclotron-generated radionuclides are used in over 70,000 patient studies per year

The National Medical Cyclotron - An Australian experience in technology

Energy Technology Data Exchange (ETDEWEB)

Barnes, R K [Australian Nuclear Science and Technology Organisation (ANSTO), Lucas Heights, NSW (Australia). National Medical Cyclotron

1998-12-31

The establishment of the National Medical Cyclotron (NMC) in the early 1990`s was the practical outcome of a vision, held by nuclear medicine professionals, to complement the available neutron-rich radionuclides produced in Australia, with neutron-deficient radionuclides. The NMC is operated by the Australian Nuclear Science and Technology Organisation (ANSTO) in collaboration with the Royal Prince Alfred Hospital (RPAH) in Sydney where the PET department is able to use the short-lived radiotracers to good advantage. Neutron-deficient radionuclides, are also produced by the NMC laboratories. The cyclotron-generated radionuclides are used in over 70,000 patient studies per year. 7 refs., 1 tab.

National Medical Cyclotron

International Nuclear Information System (INIS)

Boyd, Rex.

1991-01-01

The National Medical Cyclotron, under construction at Sydney's Royal Prince Alfred Hospital(RPAH) is to be operated by the Australian Nuclear Science and Technology Organization in collaboration with the hospital. Its main purpose is to produce radioisotopes on commercial basis for distribution to hospitals through Australia as well as short-lived radioisotopes (2 minutes to 2 hours) for immediate application at RPAH in Positron Emission Tomography, to study the dynamics of human physiology and metabolism in organs, bones and soft tissues. A list of the principal cyclotron-produced radionuclides is provided. ills

The development of cyclotron radiopharmaceuticals

Energy Technology Data Exchange (ETDEWEB)

Yang, Seung Dae; Chun, K. W.; Suh, Y. S.; Lee, J. D.; Ahn, S. H. and others

1999-03-01

The purpose of this project is to developthe radiopharmaceuticals and automatic synthetic unit for labelled compounds, and to establish mass production system of radiopharmaceuticals. These will contribute to the early diagnosis of the disease hard to cure. The contents of this project are as follows, the development of the radiopharmaceutical for imaging of cancer, the development of automatic synthesizer for the synthesis of radio-pharmaceuticals, the development of hormone derivatives labelled with {sup 12}'3I, the development of the radiopharmaceuticals for therapy of cancer labelled with cyclotron produced radionuclides, the development of radiopharmaceuticals for therapy of cancer labelled with cyclotron produced radionuclides, the development of radiopharmaceuticals for imaging of myocardial metabolism.

The development of cyclotron radiopharmaceuticals

International Nuclear Information System (INIS)

Yang, Seung Dae; Chun, K. W.; Suh, Y. S.; Lee, J. D.; Ahn, S. H. and others

1999-03-01

The purpose of this project is to develop the radiopharmaceuticals and automatic synthetic unit for labelled compounds, and to establish mass production system of radiopharmaceuticals. These will contribute to the early diagnosis of the disease hard to cure. The contents of this project are as follows, the development of the radiopharmaceutical for imaging of cancer, the development of automatic synthesizer for the synthesis of radio-pharmaceuticals, the development of hormone derivatives labelled with 12 '3I, the development of the radiopharmaceuticals for therapy of cancer labelled with cyclotron produced radionuclides, the development of radiopharmaceuticals for therapy of cancer labelled with cyclotron produced radionuclides, the development of radiopharmaceuticals for imaging of myocardial metabolism

ARRONAX, a high-energy and high-intensity cyclotron for nuclear medicine

International Nuclear Information System (INIS)

Haddad, Ferid; Guertin, Arnaud; Michel, Nathalie; Ferrer, Ludovic; Carlier, Thomas; Barbet, Jacques; Chatal, Jean-Francois

2008-01-01

This study was aimed at establishing a list of radionuclides of interest for nuclear medicine that can be produced in a high-intensity and high-energy cyclotron. We have considered both therapeutic and positron emission tomography radionuclides that can be produced using a high-energy and a high-intensity cyclotron such as ARRONAX, which will be operating in Nantes (France) by the end of 2008. Novel radionuclides or radionuclides of current limited availability have been selected according to the following criteria: emission of positrons, low-energy beta or alpha particles, stable or short half-life daughters, half-life between 3 h and 10 days or generator-produced, favourable dosimetry, production from stable isotopes with reasonable cross sections. Three radionuclides appear well suited to targeted radionuclide therapy using beta ( 67 Cu, 47 Sc) or alpha ( 211 At) particles. Positron emitters allowing dosimetry studies prior to radionuclide therapy ( 64 Cu, 124 I, 44 Sc), or that can be generator-produced ( 82 Rb, 68 Ga) or providing the opportunity of a new imaging modality ( 44 Sc) are considered to have a great interest at short term whereas 86 Y, 52 Fe, 55 Co, 76 Br or 89 Zr are considered to have a potential interest at middle term. Several radionuclides not currently used in routine nuclear medicine or not available in sufficient amount for clinical research have been selected for future production. High-energy, high-intensity cyclotrons are necessary to produce some of the selected radionuclides and make possible future clinical developments in nuclear medicine. Associated with appropriate carriers, these radionuclides will respond to a maximum of unmet clinical needs. (orig.) 5

Cyclotron-produced radioisotopes and their clinical use at the Austin PET Centre

International Nuclear Information System (INIS)

Tochon-Danguy, H.J.

1997-01-01

A Centre for Positron Emission Tomography (PET) has been established within the Department of Nuclear Medicine at the Austin and Repatriation Medical Centre in Melbourne. PET is a non-invasive technique based on the use of biologically relevant compounds labelled with short-lived positron-emitting radionuclides such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18. The basic equipment consists of a medical cyclotron (10 MeV proton and 5 MeV deuteron), six lead-shielded hot cells with associated radiochemistry facilities and a whole body PET scanner. During its first five years of operation, the Melbourne PET Centre, has pursued a strong radiolabelling development program, leading to an ambitious clinical program in neurology, oncology and cardiology. This presentation will describe the basic principles of the PET technique and review the cyclotron-produced radioisotopes and radiopharmaceuticals. Radiolabelling development programs and clinical applications are also addressed

Biomedical research with cyclotron produced radionuclides: Progress report, February 1, 1988-September 30, 1988

International Nuclear Information System (INIS)

Laughlin, J.S.; Bading, J.R.; Balis, M.E.; Benua, R.S.; Brennan, M.F.; Gelbard, A.S.

1988-09-01

This report covers the completion of research carried out in the second year of a 3 year grant. During this period the new gamma camera system, which was designed in the Biophysics Laboratory and whose fabrication was funded by the Institute, was completed and bought into operation. It has capability to monitor simultaneously 3 different radionuclide labels, and to do so rapidly. These features are essential to the metabolic studies being carried out collaboratively by Dr. James Bading and Dr. Brennan's surgical research team. Design and fabrication of this instrument was essential regardless of whether there was access to a PET unit or not. Another instrumental development is the replacement of the cyclotron magnet coils, the addition of harmonic tuning coils and other improvements. The metabolic study program with labeled amino acids in man and animals has progressed significantly as is summarized. The list of compounds prepared and labeled with positron-emitting nuclides in our laboratory, some originally prepared here, illustrates another vital and active contribution to metabolic research from this laboratory

'Serial review on clinical PET tracers'. Manufacturing and quality control of positron emitting radiopharmaceuticals produced by in-house cyclotron

International Nuclear Information System (INIS)

Saji, Hideo

2009-01-01

In order to establish PET diagnosis as a routine clinical tool, manufacture's compliance with regulations under the Good Manufacturing Practice (GMP) principle for PET radiopharmaceuticals is necessary. For this purpose, the Sub-committee on Medical Application of Positron Emitting Radionuclides, Medical Science and Pharmaceutical Committee of Japan Radioisotopes Association has proposed 'Standards for Compounds Labeled with Emitting Radionuclides Approved as Established Techniques for Medical Use'. This guideline includes the general notices, general rules for preparations, general tests for the quality control, quality of each PET agents, guideline for manufacturing environment and manufacturing process at manufacturing facilities of PET agents. Each facility should have a committee and establish an internal system to account for manufacturing compounds labeled with positron emitting radionuclides produced in the facility, and compile standards by referring to the 'Established Standard Techniques of Labeling Compounds with Emitting Radionuclides for use as Radiopharmaceuticals: approved by the Subcommittee on Medical Application of Cyclotron-Produced Radionuclides (revised in 2009)', in order to maintain the quality of radiopharmaceuticals. (author)

Cyclotron produced radionuclides: Guidelines for setting up a facility

International Nuclear Information System (INIS)

2009-01-01

Establishment of a cyclotron based radionuclide and radiopharmaceutical production facility is a major undertaking regardless of the scope and size of the facility. Regulatory demands of radiation protection and pharmaceutical manufacturing only add to the need for meticulous attention to a large number of factors in overall planning and successful implementation. Also, a significant commitment of resources, not just during the onset of the project, but also for sustained continuity further adds to the already difficult decision making process. In this publication, all these issues have been addressed and discussed conceptually for the benefit of planners and stakeholders of a new facility. The need for a clear vision and realistic scope of the programme has been repeatedly emphasized throughout this book as this aspect of project planning is absolutely vital for defining and achieving the mission and objectives of the facility. The most critical aspects in conceptualization, planning and subsequent implementation have been discussed in detail and are highlighted below as necessary actions: - Performing a feasibility study which balances wishful thinking with project viability; - Forming a task force composed of the stakeholders to evaluate strategically the various aspects of project planning to ultimately recommend the scope and objectives of the facility, and also to formulate the project plan; - Assessing the financial aspects of the project, including the set-up and operating costs of the facility through the development of business models and cost-benefit analyses; - Designing a facility and layout that encompasses the scope of the project and also takes into consideration the regulatory requirements; - Ensuring the availability of appropriately qualified and trained staff, critical for efficient and high quality operation of the facility; - Applying GMP regulations for the production of radiopharmaceutical products which are consistently safe for human use

Cyclotron-produced radioisotopes and their clinical use at the Austin PET Centre

Energy Technology Data Exchange (ETDEWEB)

Tochon-Danguy, H.J. [Centre for PET, Melbourne, VIC (Australia). Austin and Repatriation Medical Centre

1997-12-31

A Centre for Positron Emission Tomography (PET) has been established within the Department of Nuclear Medicine at the Austin and Repatriation Medical Centre in Melbourne. PET is a non-invasive technique based on the use of biologically relevant compounds labelled with short-lived positron-emitting radionuclides such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18. The basic equipment consists of a medical cyclotron (10 MeV proton and 5 MeV deuteron), six lead-shielded hot cells with associated radiochemistry facilities and a whole body PET scanner. During its first five years of operation, the Melbourne PET Centre, has pursued a strong radiolabelling development program, leading to an ambitious clinical program in neurology, oncology and cardiology. This presentation will describe the basic principles of the PET technique and review the cyclotron-produced radioisotopes and radiopharmaceuticals. Radiolabelling development programs and clinical applications are also addressed. 30 refs., 1 tab., 1 fig.

Manufacturing on the radiopharmaceuticals produced by cyclotron

International Nuclear Information System (INIS)

Ueda, Nobuo

1994-01-01

Radiopharmaceutical (RP) produced by cyclotrons are widely used for the in vivo diagnosis of various diseases such as cancer, cerebral vascular disorders and cardiac diseases. The nuclides used as RPs and their nuclear reactions, and the quantity of RPs supplied in Japan in the last five years are shown. These RPs are delivered to about 1,100 hospitals in Japan. Thallium-201 and iodine-123 showed very high growth rate. Recently, two new I-123 RPs, BMIPP and MIBG which are heart-imaging agents, have been supplied. It suggests that the quantity of I-123 will increase much more in future. The image diagnostic method using RPs is called in vivo nuclear medicine, and has become the indispensable means for medical institutions together with X-ray CT, nuclear magnetic resonance imaging and ultrasonic diagnosis. The RPs for in vivo diagnosis generally used at present are classified into those labeled with the RIs produced with cyclotrons and those labeled with Tc-99m formed by the decay of Mo-99. The quantity being used is overwhelmingly more in the latter, but the former shows the tendency of growth. The commercial production of cyclotron RIs for medical use, the chemical forms and the diagnostic purposes of the RPs using cyclotron RIs, and the state of use of the cyclotron-produced RPs are reported. (K.I.)

Study of the activation of the parts components of the CV-28 cyclotron

International Nuclear Information System (INIS)

Fajardo, P.W.

1986-08-01

The CV-17 cyclotron, isochronous, compact, of variable energy is an accelerator of charged particles and is applied in several situations such as: radioisotopes production, neutron production, irradiation damage analysis, activation analysis. During the production of the particle beams, the parts components of the interior of the cyclotron are irradiated and become radioactive. Due the fact of the cyclotron require maintenance, the knowledgement of the radionuclides present is of primordial importance of the view point of the radioprotection. Taking the excitation function of a nuclear reaction is observed that determined reaction may happen and produce a radionuclide. The radionuclides formed in the parts components by charged particles are presented. (V.R.B.)

Cyclotron Produced Radionuclides: Guidance on Facility Design and Production of [18F]Fluorodeoxyglucose (FDG)

International Nuclear Information System (INIS)

2012-01-01

Positron emission tomography (PET) has advanced rapidly in recent years and is becoming an indispensable imaging modality for the evaluation and staging of cancer patients. A key component of the successful operation of a PET centre is the on-demand availability of radiotracers (radiopharmaceuticals) labelled with suitable positron emitting radioisotopes. Of the hundreds of positron labelled radiotracers, 2-[ 18 F]-fluoro-2-deoxy-D-glucose (FDG) is the most successful and widely used imaging agent in PET today. While FDG is utilized largely in oncology for the management of cancer patients, its applications in neurology and cardiology are also steadily growing. A large number of PET facilities have been established in Member States over the past few years, and more are being planned. The design and operation of a facility for the production of FDG requires attention to detail, in particular the application of good manufacturing practices (GMP) guidelines and quality assurance. The product must conform to the required quality specifications and must be safe for human use. This book is intended to be a resource manual with practical information for planning and operating an FDG production facility, including design and implementation of the laboratories, facility layout, equipment, personnel and FDG quality assessment. GMP and quality management are discussed only briefly, since these topics are covered extensively in the IAEA publication Cyclotron Produced Radionuclides: Guidelines for Setting up a Facility (Technical Reports Series No. 471). It should be noted that manufacturing processes and quality specifications for FDG are not currently globally harmonized, and these do vary to some extent. However, there is no disagreement over the need to ensure that the product is manufactured in a controlled manner, that it conforms to applicable quality specifications and that it is safe for human use. Administrators, managers, radiopharmaceutical scientists, production

Evaluation of residual radioactivity and dose rate of a target assembly in an IBA cyclotron

Energy Technology Data Exchange (ETDEWEB)

Hwang, Seon Yong; Kim, Young Ju; Lee, Seung Wook [School of Mechanical Engineering, Pusan National University (Korea, Republic of)

2016-12-15

When a cyclotron produces 18F-, accelerated protons interact with metal parts of the cyclotron machine and induces radioactivity. Especially, the target window and chamber of the target assembly are the main parts where long-lived radionuclides are generated as they are incident by direct beams. It is of great importance to identify radionuclides induced in the target assembly for the safe operation and maintenance of a cyclotron facility. In this study, we analyzed major radionuclides generated in the target assembly by an operation of the Cyclotron 18/9 machine and measured dose rates after the operation to establish the radiation safety guideline for operators and maintenance personnel of the machine. Gamma spectroscopy with HPGe was performed on samples from the target chamber and Havar foil target window to identify the radionuclides generated during the operation for production of 18F-- isotope and their specific activity. Also, the dose rates from the target were measured as a function of time after an operation. These data will help improve radiological safety of operating the cyclotron facilities.

Report of an International Atomic Energy Agency's Advisory Group meeting on ''Quality control of cyclotron-produced radiopharmaceuticals''

International Nuclear Information System (INIS)

Vera-Ruiz, H.; Marcus, C.S.; Pike, V.W.

1990-01-01

The special requirements for the preparation and quality control of cyclotron-produced tracers have been described with particular reference to the production of short-lived positron-emitting radiopharmaceuticals. The regulatory philosophy and training aspects of implementation are considered followed by various aspects of quality of control including good production practice, chemical purity, radionuclide purity, radiochemical purity, specific activity, shelf-life and sterility and apyrogenicity. Finally some organizational aspects such as legal and regulatory aspects, supply of radiopharmaceuticals and professional liability are considered. (UK)

First-in-Human PET/CT Imaging of Metastatic Neuroendocrine Neoplasms with Cyclotron-Produced 44Sc-DOTATOC: A Proof-of-Concept Study.

Science.gov (United States)

Singh, Aviral; van der Meulen, Nicholas P; Müller, Cristina; Klette, Ingo; Kulkarni, Harshad R; Türler, Andreas; Schibli, Roger; Baum, Richard P

2017-05-01

44 Sc is a promising positron emission tomography (PET) radionuclide (T 1/2  = 4.04 hours, E β+average  = 632 keV) and can be made available, using a cyclotron production route, in substantial quantities as a highly pure product. Herein, the authors report on a first-in-human PET/CT study using 44 Sc-DOTATOC prepared with cyclotron-produced 44 Sc. The production of 44 Sc was carried out through the 44 Ca(p,n) 44 Sc nuclear reaction at Paul Scherrer Institut, Switzerland. After separation, 44 Sc was shipped to Zentralklinik Bad Berka, Germany, where radiolabeling was performed, yielding radiochemically pure 44 Sc-DOTATOC. Two patients, currently followed up after peptide receptor radionuclide therapy of metastatic neuroendocrine neoplasms, participated in this proof-of-concept study. Blood sampling was performed before and after application of 44 Sc-DOTATOC. PET/CT acquisitions, performed at different time points after injection of 44 Sc-DOTATOC, allowed detection of even very small lesions on delayed scans. No clinical adverse effects were observed and the laboratory hematological, renal, and hepatic profiles remained unchanged. In this study, cyclotron-produced 44 Sc was used in the clinic for the first time. It is attractive for theranostic application with 177 Lu, 90 Y, or 47 Sc as therapeutic counterparts. 44 Sc-based radiopharmaceuticals will be of particular value for PET facilities without radiopharmacy, to which they can be shipped from a centralized production site.

Cyclotron Production of Radionuclides for Nuclear Medicine at Academic Centers

Science.gov (United States)

Lapi, Suzanne

2016-09-01

The increase in use of radioisotopes for medical imaging has led to the development of new accelerator targetry and separation techniques for isotope production. For example, the development of longer-lived position emitting radionuclides has been explored to allow for nuclear imaging agents based on peptides, antibodies and nanoparticles. These isotopes (64Cu, 89Zr, 86Y) are typically produced via irradiation of solid targets on smaller cyclotrons (10-25 MeV) at academic or hospital based facilities. Recent research has further expanded the toolbox of PET tracers to include additional isotopes such as 52Mn, 55Co, 76Br and others. The smaller scale of these types of facilities can enable the straightforward involvement of students, thus adding to the next generation of nuclear science leaders. Research pertaining to development of robust and larger scale production technologies including solid target systems and remote systems for transport and purification of these isotopes has enabled both preclinical and clinical imaging research for many diseases. In particular, our group has focused on the use of radiolabeled antibodies for imaging of receptor expression in preclinical models and in a clinical trial of metastatic breast cancer patients.

History of medical radionuclide production.

Science.gov (United States)

Ice, R D

1995-11-01

Radionuclide production for medical use originally was incidental to isotope discoveries by physicists and chemists. Once the available radionuclides were identified they were evaluated for potential medical use. Hevesy first used 32P in 1935 to study phosphorous metabolism in rats. Since that time, the development of cyclotrons, linear accelerators, and nuclear reactors have produced hundreds of radionuclides for potential medical use. The history of medical radionuclide production represents an evolutionary, interdisciplinary development of applied nuclear technology. Today the technology is represented by a mature industry and provides medical benefits to millions of patients annually.

Cyclotron Produced Radionuclides: Guidance on Facility Design and Production of [{sup 18}F]Fluorodeoxyglucose (FDG)

Energy Technology Data Exchange (ETDEWEB)

NONE

2012-01-15

Positron emission tomography (PET) has advanced rapidly in recent years and is becoming an indispensable imaging modality for the evaluation and staging of cancer patients. A key component of the successful operation of a PET centre is the on-demand availability of radiotracers (radiopharmaceuticals) labelled with suitable positron emitting radioisotopes. Of the hundreds of positron labelled radiotracers, 2-[{sup 18}F]-fluoro-2-deoxy-D-glucose (FDG) is the most successful and widely used imaging agent in PET today. While FDG is utilized largely in oncology for the management of cancer patients, its applications in neurology and cardiology are also steadily growing. A large number of PET facilities have been established in Member States over the past few years, and more are being planned. The design and operation of a facility for the production of FDG requires attention to detail, in particular the application of good manufacturing practices (GMP) guidelines and quality assurance. The product must conform to the required quality specifications and must be safe for human use. This book is intended to be a resource manual with practical information for planning and operating an FDG production facility, including design and implementation of the laboratories, facility layout, equipment, personnel and FDG quality assessment. GMP and quality management are discussed only briefly, since these topics are covered extensively in the IAEA publication Cyclotron Produced Radionuclides: Guidelines for Setting up a Facility (Technical Reports Series No. 471). It should be noted that manufacturing processes and quality specifications for FDG are not currently globally harmonized, and these do vary to some extent. However, there is no disagreement over the need to ensure that the product is manufactured in a controlled manner, that it conforms to applicable quality specifications and that it is safe for human use. Administrators, managers, radiopharmaceutical scientists

Medical cyclotron basic concepts and its applications

International Nuclear Information System (INIS)

Kumar, Rajeev; Sonkawade, R.G.

2012-01-01

More than 3000 nuclides are known, of which approximately 2700 are radioactive, and rest are stable. The majority of radionuclides are artificially produced in the reactor and cyclotron. In a cyclotron, Charge particle such as proton, Deuteron, á (Alpha) particle, 3 He particles and so forth are accelerated in circular paths within the Dees under vacuum by means of an electromagnetic field. These accelerated particles can possess few KeV to several BeV of kinetic energy depending on the design of the cyclotron. At our setup we have an 11 MeV dual beam multi target cyclotron which is capable producing 11 C, 13 N, 15 O, 18 F and 2 F radioisotopes and all have been successfully produced and tested in our lab. Earlier cyclotrons were the best source of high-energy beams for nuclear physics experiments; several cyclotrons are still in use for this type of research. Cyclotrons can be used to treat cancer. Ion beams from cyclotrons can be used, as in proton therapy. The positron emitting isotopes are suitable for PET imaging. As discussed we are producing mainly Carbon-11, Nitrogen-13, Oxygen-15, and Fluorine-18: These are positron emitters used in PET for studying brain physiology and pathology, in particular for localizing epileptic focus, and in dementia, psychiatry and neuropharmacology studies. So these are having significant role in diagnosis of Oncological, Neurological and Cardiological disorder. More than ninety percent we are producing 18 F in FDG. 18 F in FDG (Flouro-Deoxy-glucose) has become very important in detection of cancers and the monitoring of progress in their treatment, using PET. Medical cyclotron is complex equipment requiring delicate handling by highly trained personnel. The aim of this article is to highlight few finer aspects of Medical cyclotron operation, including precautions for safety and smooth functioning of this sophisticated equipment. (author)

New radionuclide generator systems for use in nuclear medicine

International Nuclear Information System (INIS)

Atcher, R.W.

1979-01-01

A current emphasis in nuclear medicine is to better match the physical lifetime of the radionuclides used in vivo for diagnosis and treatment to the biological lifetime of the diagnostic procedure or to minimize radiation dose to areas other than those to be treated. In many cases the biological lifetime is on the order of minutes. Since the direct production of radionuclides with half lives of minutes requires the user to be near a suitable reactor or accelerator, this study was undertaken to produce short-lived radionuclides indirectly. If a long-lived radionuclide decays into a short-lived radionuclide, quick separation of the daughter activity from the parent enables the user to have a short-lived daughter while freeing him from the constraint of proximity to a cyclotron. Systems where a short-lived daughter is separated from a long-lived parent are called radionuclide generators. Two generator systems were developed for use in nuclear medicine, one in diagnostic work and the other for therapeutic work. The yield and breakthrough characteristics were within the limits required to minimize unnecessary radiation exposure in patients. Two parent radionuclides were produced using 4 He beams available from medium energy cyclotrons. The yield was high enough to produce generators that would be useful in clinical applications

Radiation protection of cyclotron vault with maze in PET Cyclotron Center

International Nuclear Information System (INIS)

Fueloep, Marko

2003-01-01

The PET Cyclotron center (PCC) is a complex for production, research and application of positron radiopharmaceuticals for PET (Positron Emission Tomography), which was commissioned this year (2004) in Bratislava, Slovak Republic. Positron radionuclides are produced by 18/9 MeV proton/deuteron cyclotron CYCLONE 18/9. Radiation protection of personnel and inhabitants against ionizing radiation in the PCC is solved with regard to the ICRP recommendations and Slovak regulatory system, protection rules and criteria and optimization of radiation protection. In the article comparisons of calculated and measured neutron and gamma dose equivalent rates around the CYCLONE 18/9 and at various points behind the shielding of cyclotron vault with maze are presented. Description of the CYCLONE 18/9 as a source of angular distribution of neutron energy spectra (production of 18 F was considered) was simulated by Monte Carlo code MCNPX. Code MCNP4B was used for shielding calculation of cyclotron vault with maze. Neutron energy spectra behind the shielding were measured by Bonner spectrometer. The values of neutron dose equivalent, which were calculated and measured around the CYCLONE 18/9 and at various points behind the shielding of cyclotron vault with maze, are within the range of factor 2. (authors)

Medical cyclotrons

International Nuclear Information System (INIS)

Wolf, A.P.

1976-01-01

Cyclotrons as tools for therapy and for the production of radionuclides for use in nuclear medicine have been extensively reviewed in the literature. The current world status with respect to cyclotrons used primarily for research, development and application in nuclear medicine is reviewed here in the context of geographical distribution and type of use, presently available commercial types, machine characteristics and trends. Aspects of design requirements from a user perspective such as machine, beam and target characteristics are covered. Some special problems concerning many factors which can lead to effective production of the desired radionuclide or product are considered in light of machine characteristics. Consideration is also given to future directions for accelerators in nuclear medicine

Cyclotron production of radionuclides in aqueous target matrices as alternative to solid state targetry. Production of Y-86 as example

Energy Technology Data Exchange (ETDEWEB)

Vogg, A.T.J.; Lang, R.; Meier-Boeke, P.; Scheel, W.; Reske, S.N.; Neumaier, B. [Universitaetsklinikum Ulm (Germany). Abt. Nuklearmedizin

2004-07-01

Commonly used ''organic'' positron emitting radionuclides {sup 18}F, {sup 11}C, {sup 13}N, and {sup 15}O are simply obtained from gaseous or aqueous targets, which enable an automated handling of target, i.e. both, filling and radionuclide delivery to a hot cell containing a chemistry processing and/or labelling module. In the recent years other - mostly metallic - radionuclides for PET gained more and more interest, since they can be used as surrogates for therapeutic nuclides attached to biomolecules like peptides or antibodies. The implication for surrogate nuclides results from the circumstance that an optimum dosimetric regime in endo radiotherapy relies on quantitative pharmacokinetic data obtained only by non invasive in vivo PET scans. However, for production of these alternative positron emitters the vast majority of them affords solid targets in form of metal foils, oxide or salt pellets which can not be operated by an automated processing. Those solid target systems have to be mounted and dismounted after irradiation by man, leading to two major disadvantages. First, manual cyclotron intervention is practically unsuited for daily routine radionuclide production and second the operating staff receives high radiation doses from the activated target. An alternative could be the irradiation of aqueous salts of target isotopes, allowing automated target operation. The major requirements are firstly a thermal stability of the dissolved compound, secondly the avoidance of counter ions containing nuclides which produce long-lived radionuclides under irradiation and thirdly a high solubility of the salt in the aqueous matrix. Here we report the proof of principle of the new radionuclide production concept by irradiation of strontium nitrate dissolved in water in order to produce {sup 86}Y (cf.). (orig.)

Operational health and physics service during the maintenance of the Australian National Medical Cyclotron

International Nuclear Information System (INIS)

Mukherjee, B.

1994-01-01

Modern Medical Cyclotrons use intense beams of high energy protons or deuterons to produce large activities of short and medium lived radionuclides. After continuous operation for prolonged periods the Cyclotron components become activated through various nuclear interactions therefore, the risk of personal radiation hazard while handling such activated cyclotron components is high. This paper describes all operational aspects of the Health Physics service evolved during the first preventative maintenance program of the Australian National Medical Cyclotron, which took place in June 1993. 5 refs., 3 tabs., 2 figs

57 Co produced in cyclotron

International Nuclear Information System (INIS)

Landini, Liliane; Osso Junior, Joao Alberto

2000-01-01

The Cyclotron CV-28 of IPEN-CNEN/SP is a particle accelerator, used mainly in the radioisotope production, applied in 'in vivo' diagnosis in nuclear medicine. Some of them are employed in the calibration of Diagnosis equipment, such as gamma and X-rays detectors. Co-57 is an example of this application. A natural nickel foil was used as target and irradiated with proton beams of 24 MeV energy. The radioactivity analysis of the irradiated target was performed by Gamma Spectroscopy with a HPGe detector. A 259,74MBq (7,02 mCi) Co-57 source was prepared, 67 days after the last bombardment, with impurity levels of 1.13% for Co-56 and 1.29% for Co-58. The thick target yields for Co-57 and for the main radionuclidic impurities were measured, after the chemical separation of the irradiated target, extrapolated to the last EOB: 1.076 MBq (29.09 mCi)/mA.h, 0.012 MBq (0.33 mCi)/mA.h and 0.014 MBq (0.37 mCi)/mA.h, for Co-57, Co-56 and Co-58, respectively. (author)

Preparation of 199Tl radionuclide on U-120 (R-7M) cyclotron

International Nuclear Information System (INIS)

Glukhov, G.G.; Komov, A.I.; Maslennikov, Yu.S.; Malinin, A.B.; Skuridin, V.S.

1989-01-01

The possibility of preparation of 199 Tl radionuclide, which can be successfully used instead of thallium-201 in radiopharmaceutical compound for medicine diagnosis due to nuclear-physical characteristics, is studied. It is established that thallium-199 free from thallium-298, but with thallium-200 impurity, is formed under irradiation of gold-197 target by 27.2-28 MeV energy α-particles. The construction of a thin-layer gold target allowing to decrease thallium-200 impurity up to >0.5 % is developed and tested. Perspectivity of thallium-199 production at domestic cyclotrons P-7M and u-120 is shown. 4 refs.; 2 figs.; 3 tabs

Radiation shielding analysis of medical cyclotron at Radiation Medicine Centre, Parel

International Nuclear Information System (INIS)

Gathibandhe, M.V.; Agrawal, R.A.; Utge, C.G.

2003-01-01

Full text: PET (Positron Emission Tomography) is a diagnostic method to obtain 3-D functional images of the distribution of radio-nuclides introduced in the human body as tracers for specific biological processes. Tracers are produced by bombardment of different target nuclides by protons and deuterons of high energy produced in the cyclotron. A Wipro-GE medical cyclotron was installed in the basement of RMC, Parel. Shielding around the cyclotron is provided in the form of borated concrete walls of required thickness to limit dose rates to design values as per AERB criteria. The roof of the cyclotron room is made of heavy concrete. Entry in to the room is through a maze. Shielding analysis for the cyclotron room has been carried out using computer code ANISN. The maze has been analyzed using code MCNP. Based on the analysis carried out additional shielding was recommended to meet the design requirements. The paper discusses the shielding analysis carried out for the cyclotron room and the maze. Dose rate estimated at various locations are highlighted

MC-50 AVF cyclotron operation

Energy Technology Data Exchange (ETDEWEB)

Chae, Jong Seo; Lee, Dong Hoon; Kim, You Seok; Park, Chan Won; Lee, Yong Min; Hong, Sung Seok; Lee, Min Yong

1995-12-01

The first cyclotron in Korea, MC-59 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-70 .mu.A. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed. (author). 8 tabs., 17 figs., 10 refs.

MC-50 AVF cyclotron operation

International Nuclear Information System (INIS)

Kim, Yu Seok; Chai, Jong Seo; Bak, Seong Ki; Park, Chan Won; Jo, Young Ho; Hong, Seong Seok; Lee, Min Yong; Jang Ho Ha

2000-01-01

The first cyclotron in Korea, MC-50 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-60μA. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23 days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed

MC-50 AVF cyclotron operation

Energy Technology Data Exchange (ETDEWEB)

Kim, Yu Seok; Chai, Jong Seo; Bak, Seong Ki; Park, Chan Won; Jo, Young Ho; Hong, Seong Seok; Lee, Min Yong; Jang Ho Ha

2000-01-01

The first cyclotron in Korea, MC-50 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-60{mu}A. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23 days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed.

MC-50 AVF cyclotron operation

International Nuclear Information System (INIS)

Chae, Jong Seo; Lee, Dong Hoon; Kim, You Seok; Park, Chan Won; Lee, Yong Min; Hong, Sung Seok; Lee, Min Yong.

1995-12-01

The first cyclotron in Korea, MC-59 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-70 .mu.A. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed. (author). 8 tabs., 17 figs., 10 refs

Recent achievements in Tc-99m radiopharmaceutical direct production by medical cyclotrons.

Science.gov (United States)

Boschi, Alessandra; Martini, Petra; Pasquali, Micol; Uccelli, Licia

2017-09-01

99m Tc is the most commonly used radionuclide in the field of diagnostic imaging, a noninvasive method intended to diagnose a disease, assess the disease state and monitor the effects of treatments. Annually, the use of 99m Tc, covers about 85% of nuclear medicine applications. This isotope releases gamma rays at about the same wavelength as conventional X-ray diagnostic equipment, and owing to its short half-life (t ½  = 6 h) is ideal for diagnostic nuclear imaging. A patient can be injected with a small amount of 99m Tc and within 24 h almost 94% of the injected radionuclide would have decayed and left the body, limiting the patient's radiation exposure. 99m Tc is usually supplied to hospitals through a 99 Mo/ 99m Tc radionuclide generator system where it is produced from the β decay of the parent nuclide 99 Mo (t ½  = 66 h), which is produced in nuclear reactors via neutron fission. Recently, the interruption of the global supply chain of reactor-produced 99 Mo, has forced the scientific community to investigate alternative production routes for 99m Tc. One solution was to consider cyclotron-based methods as potential replacement of reactor-based technology and the nuclear reaction 100 Mo(p,2n) 99m Tc emerged as the most worthwhile approach. This review reports some achievements about 99m Tc produced by medical cyclotrons. In particular, the available technologies for target design, the most efficient extraction and separation procedure developed for the purification of 99m Tc from the irradiated targets, the preparation of high purity 99m Tc radiopharmaceuticals and the first clinical studies carried out with cyclotron produced 99m Tc are described.

An investigation into the technical feasibility of cyclotron production of technetium-99m

International Nuclear Information System (INIS)

Egan, G.F.; Lagunas-Solar, M.C.

1994-01-01

The role of technetium-99m in nuclear medicine is well established with 80 per cent to 90 per cent of all nuclear medicine studies utilising this isotope. Technetium-99m is currently produced from nuclear reactors via production of the parent radionuclide molybdenum-99. The reactor production of 99m Tc has both significant financial and environmental costs, with unresolved problems in the areas of radioactive waste disposal and reactor decommissioning. Recent scientific publications have indicated that medical quality 99m Tc may be produced using cyclotrons without having the associated problems of waste disposal and decommissioning. Further scientific research is now required to demonstrate the feasibility of this cyclotron production technique. A collaboration between the Cyclotron and PET Centre, Austin Hospital, the National Medical Cyclotron, ANSTO, Sydney, and the Crocker Nuclear Laboratory, University of California, Davis, USA has been proposed. The general objective of the proposed collaboration is to acquire additional scientific data to evaluate the 99m Tc cyclotron production method and to determine the feasibility of cyclotron technology for Australian nuclear medicine. 16 refs., 2 tabs

Preparation of proton rich radionuclides in support of radiochemical analysis

International Nuclear Information System (INIS)

Jerome, Simon; Larijani, Cyrus; Parker, David

2012-01-01

The production of proton rich radionuclides supports a wide range of radiochemical analyses via radioactive yield tracers ( 95m Tc and 236 Pu). In recent years, NPL and the University of Birmingham cyclotron have collaborated to produce these, and other, radionuclides. - Highlights: ► In this paper we options for the production of Tc and Pu tracers. ► The irradiation and measurement of targets producing Tc-95 m and Pu-236 are described. ► Options for production are discussed. ► The results of this study and future work needed are described.

Improving cancer treatment with cyclotron produced radionuclides. Progress report, February 1987--September 1989

Energy Technology Data Exchange (ETDEWEB)

Larson, S.M.

1989-12-31

This report is divided into six sections, each section dealing with a separate aspect of the program. The six sections are entitled (1) In Vivo Measurement of Amino Acid Transport and Protein Synthesis, (2) Angiogenesis in Human Gliomas: Correlations with Blood Flow and Transport of C-11 AIB, (3) Use of F-18 Fluoropyrimidines for Design and Evaluation of Regional and Systemic Chemotherapeutic Strategies in Human Adenocarcinomas of the Gastrointestinal Tract, (4) Enzymatic Synthesis of Metabolites Labeled with N-13 or C-11, (5) Synthesis of Amino Acids Labeled with C-11, and (6) Instrumentation: Cyclotron and Imaging Systems.

Atmospheric tracer study of the emissions from the University of Michigan Cyclotron/PET Facility

International Nuclear Information System (INIS)

Scofield, P.A.

1986-01-01

The University of Michigan (U of M) Cyclotron/Positron Emission Tomography (PET) facility consists of a cyclotron (Model CS-30, The Cyclotron Corporation), radiochemistry laboratory, and Pet scanner. Accelerator-produced radioactive materials, such as, carbon-11 and oxygen-15 are typically emitted from the Cyclotron/PET facility through short stacks located on the roof. This project studied the dispersion of emissions from the facility within the medical complex. To achieve this purpose, the research project had three phases: a physical modeling study; a preliminary field smoke release study; and, a field study using a tracer gas to simulate emission dispersion from the U of M Cyclotron/PET facility vault stack. The objective was to determine normalized concentrations, under selected wind directions and speeds, for use in establishing radionuclide concentrations at the air intakes of the Cyclotron/PET facility and surrounding buildings and at selected ground-level locations

Practicality of the cyclotron production of radiolanthanide 142Pr. A potential for therapeutic applications and biodistribution studies

International Nuclear Information System (INIS)

Mahdi Sadeghi; Bakht, M.K.; Leila Mokhtari

2011-01-01

Radiolanthanide praseodymium-142 (T 1/2 = 19.12 h, E β - = 2.162 MeV (96.3%), E γ = 1575 keV (3.7%)) due to its high β-emission and low specific γ-emission could not only be a therapeutic radionuclide, but also a suitable radionuclide in order for biodistribution studies. Conventionally, 142 Pr produces via 141 Pr(n,γ) 142 Pr reaction by irradiation in a low-fluence reactor and this study evaluates cyclotron reaction production of it. 142 Pr excitation function via nat La(α,n) 142 Pr, 142 Ce(p,n) 142 Pr, and nat Pr(d,p) 142 Pr reactions were calculated by TALYS-1.2 and EMPIRE-2.19beta codes, and with the data taken from the TENDL-2010 database. In addition, we compared them with the reported measurement by experimental data. Requisite thickness of targets was obtained by SRIM-2010 code for each reaction. The 142 Pr production yield was evaluated with attention to excitation function and stopping power. Similar to reactor produced 142 Pr; 141 Pr impurity exists in cyclotron produced 142 Pr while it could not be separated by chemical methods. Therefore, cyclotron and reactor produced 142 Pr will be in carrier added form. (author)

Effective dose to immuno-PET patients due to metastable impurities in cyclotron produced zirconium-89

Science.gov (United States)

Alfuraih, Abdulrahman; Alzimami, Khalid; Ma, Andy K.; Alghamdi, Ali; Al Jammaz, Ibrahim

2014-11-01

Immuno-PET is a nuclear medicine technique that combines positron emission tommography (PET) with radio-labeled monoclonal antibodies (mAbs) for tumor characterization and therapy. Zirconium-89 (89Zr) is an emerging radionuclide for immuno-PET imaging. Its long half-life (78.4 h) gives ample time for the production, the administering and the patient uptake of the tagged radiopharmaceutical. Furthermore, the nuclides will remain in the tumor cells after the mAbs are catabolized so that time series studies are possible without incurring further administration of radiopharmarceuticals. 89Zr can be produced in medical cyclotrons by bombarding an yttrium-89 (89Y) target with a proton beam through the 89Y(p,n)89Zr reaction. In this study, we estimated the effective dose to the head and neck cancer patients undergoing 89Zr-based immune-PET procedures. The production of 89Zr and the impurities from proton irradiation of the 89Y target in a cyclotron was calculated with the Monte Carlo code MCNPX and the nuclear reaction code TALYS. The cumulated activities of the Zr isotopes were derived from real patient data in literature and the effective doses were estimated using the MIRD specific absorbed fraction formalism. The estimated effective dose from 89Zr is 0.5±0.2 mSv/MBq. The highest organ dose is 1.8±0.2 mSv/MBq in the liver. These values are in agreement with those reported in literature. The effective dose from 89mZr is about 0.2-0.3% of the 89Zr dose in the worst case. Since the ratio of 89mZr to 89Zr depends on the cooling time as well as the irradiation details, contaminant dose estimation is an important aspect in optimizing the cyclotron irradiation geometry, energy and time.

SU-E-T-534: Level of Residual Radioactivity of Activated Parts of a Decommissioned Cyclotron

International Nuclear Information System (INIS)

Choi, HHF; Leung, TM; Chiu, TL; Yang, B; Wu, PM; Cheung, KY; Yu, SK

2015-01-01

Purpose: CTI cyclotron RDS-111 was used at the Hong Kong Sanatorium and Hospital (HKSH) to produce radiopharmaceuticals and radioactive tracers for diagnostic scans between 1999 and 2007. During the operation, some machine components became radioactive by activation. For the safety of staff, decommissioning took place in 2009, two years after the cyclotron had stopped operation. This study investigates the residual radioactivity and radionuclides found in different cyclotron components in 2014 in compliance with the local regulations in Hong Kong for transfer of radioactive waste. Methods: A representative sample of each part was counted using a high-purity germanium detector (manufacturer: ORTECT) for at least four hours. GammaVision, a multichannel analyzer software, was used to identify the radionuclides found in the cyclotron components, as well as the associated activities. A standard library and a Mariscotti peak search algorithm were used to identify the present radionuclides. Only radionuclides with half-life greater than 180 days were considered. Results: Among the components, the Havar target foil has the highest specific activity ((4.6±0.6)×10 2 Bq/g), with Co-60 being the most prominent ((3.8±0.5)×10 2 Bq/g). The total activity of the target foil, however, is still low due to its small mass of 0.04 g. Radioisotopes Mn-54 (46±6 Bq/g), Na-22 (6.8±0.8 Bq/g), Co-57 (7.3±0.9 Bq/g), and Fe-59 (6.0±0.9 Bq/g) have also been detected in the target foil. The target window holder and the vacuum window register a specific activity of 88.3±0.6 Bq/g and 48.6±0.1 Bq/g, respectively. Other components, such as the collimator, the target tube, the valve body and the beamline, are also found with trace amounts of radionuclides. Conclusion: Even seven years after the cyclotron had stopped operation, some components still exhibited residual radioactivity from activation exceeding the IAEA clearance levels. Special consideration for radiological protection may need

Measured radionuclide production from copper, gold and lead spallation targets

Energy Technology Data Exchange (ETDEWEB)

Parish, T.A.; Belian, A.P. [Texas A & M Univ., College Station, TX (United States)

1995-10-01

Spallation target materials are chosen so as to produce large numbers of neutrons while at the same time avoiding the creation of long-lived radioactive wastes. While there has been considerable research to determine the number of neutrons produced per incident particle for various target materials, there has been less effort to precisely quantify the types and amounts of radionuclides produced. Accurate knowledge of the radioactive species produced by spallation reactions is important for specifying waste disposal criteria for targets. In order to verify the production rates calculated by LAHET, a study has been conducted using the Texas A&M University (TAMU) Cyclotron to measure radionuclide yields from copper, gold, and lead targets.

First meeting on the CRP 'standardized high current solid targets for cyclotron production of diagnostic and therapeutic radionuclides'

International Nuclear Information System (INIS)

Winkel, P. van den

2000-01-01

The Cyclotron Department of the VUB has three groups performing research in the field of target development, production of radionuclides and their application in nuclear medicine. 1. The Physics Group is busy on the optimization of beam parameters, on the determination of cross sections and on neutron spectrometry. 2. The Inorganic Radiochemistry Group performs research on solid target electroplating (Tl, Zn, Cd, Rh ... ), on optimisation of target carrier geometry and cooling and on automated PC-controlled radiochemistry (Tl-201, Ga-67, In-111) and recovery systems and the associated software written in Modula-2 and Visual Basic. 3. The Organic Radiochemistry Group develops new techniques for radiolabelling of organic molecules (fatty acids, neuroleptics, synthetic polypeptides...) useful in diagnostic and therapeutic nuclear medicine. All three groups take part in bulk productions of radionuclides

Cyclotron for medicine and research; Zyklotron fuer Medizin und Forschung

Energy Technology Data Exchange (ETDEWEB)

Anon.

2012-11-01

35 tons, weighs the major medical device, which has been delivered in early may at the Julic campus. A heavy-duty crane hoisted the new compact cyclotron to its destination, an underground concrete bunker. There it will from summer 2013 produce radionuclides for the synthesis of radiopharmaca, by which it is possible among others to detect tumors, to pursue metabolic processes, and to investigate the mechanisms of action of drugs.

A Radium-223 microgenerator from cyclotron-produced trace Actinium-227

International Nuclear Information System (INIS)

Abou, Diane S.; Pickett, Juile; Mattson, John E.; Thorek, Daniel L.J.

2017-01-01

The alpha particle emitter Radium-223 dichloride ("2"2"3RaCl_2) has recently been approved for treatment of late-stage bone metastatic prostate cancer. There is considerable interest in studying this new agent outside of the clinical setting, however the supply of "2"2"3Ra is limited and expensive. We have engineered a "2"2"3Ra microgenerator using traces of "2"2"7Ac previously generated from cyclotron-produced "2"2"5Ac. Radiochemically pure "2"2"3RaCl_2 was made, characterized, evaluated in vivo, and the source was recovered in high yield for regeneration of the microgenerator. - Highlights: • A "2"2"3Ra microgenerator was built using residual "2"2"7Ac from cyclotron-produced "2"2"5Ac. • Following "2"2"5Ac decay, the residual "2"2"7Ac was processed into pure "2"2"3Ra. • "2"2"7Ac and "2"2"7Th were recovered in high yield for a permanent supply of "2"2"3Ra. • Clinically supplied and generator-produced "2"2"3Ra have equivalent in vivo distribution. • Microdose column provides sufficient material for research use.

The fate and importance of radionuclides produced in nuclear events

Energy Technology Data Exchange (ETDEWEB)

Shore, B; Anspaugh, L; Chertok, R; Gofman, J; Harrison, F; Heft, R; Koranda, J; Ng, Y; Phelps, P; Potter, G; Tamplin, A [Lawrence Radiation Laboratory, University of California, Livermore, CA (United States)

1969-07-01

Some of the major program at the Bio-Medical Division concerned with the fate and importance of the fission products, the radionuclides induced in the device materials, the radionuclides induced in the environment surrounding the device, and the tritium produced in Plowshare cratering events will be discussed. These programs include (1) critical unknowns in predicting organ and body burdens from radionuclides produced in cratering events; (2) the analysis with a high-resolution solid state gamma ray spectrometer of radionuclides in complex biological and environmental samples; (3) the characterization of radioactive particles from cratering detonation; (4) the biological availability to beagles, pigs and goats of radionuclides in Plowshare debris; (5) the biological availability to aquatic animals of radionuclides in Plowshare and other nuclear debris and the biological turnover of critical nuclides in specific aquatic animals; (6) the biological availability of Plowshare and other nuclear debris radionuclides to dairy cows and the transplacental transport of debris radionuclides in the dairy cow; (7) the persistence and behavior of radionuclides, particularly tritium, at sites of Plowshare and other nuclear detonations; and (8) somatic effects of Low Dose Radiation: Chromosome studies. (author)

The fate and importance of radionuclides produced in nuclear events

International Nuclear Information System (INIS)

Shore, B.; Anspaugh, L.; Chertok, R.; Gofman, J.; Harrison, F.; Heft, R.; Koranda, J.; Ng, Y.; Phelps, P.; Potter, G.; Tamplin, A.

1969-01-01

Some of the major program at the Bio-Medical Division concerned with the fate and importance of the fission products, the radionuclides induced in the device materials, the radionuclides induced in the environment surrounding the device, and the tritium produced in Plowshare cratering events will be discussed. These programs include (1) critical unknowns in predicting organ and body burdens from radionuclides produced in cratering events; (2) the analysis with a high-resolution solid state gamma ray spectrometer of radionuclides in complex biological and environmental samples; (3) the characterization of radioactive particles from cratering detonation; (4) the biological availability to beagles, pigs and goats of radionuclides in Plowshare debris; (5) the biological availability to aquatic animals of radionuclides in Plowshare and other nuclear debris and the biological turnover of critical nuclides in specific aquatic animals; (6) the biological availability of Plowshare and other nuclear debris radionuclides to dairy cows and the transplacental transport of debris radionuclides in the dairy cow; (7) the persistence and behavior of radionuclides, particularly tritium, at sites of Plowshare and other nuclear detonations; and (8) somatic effects of Low Dose Radiation: Chromosome studies. (author)

Graphical user interface for yield and dose estimations for cyclotron-produced technetium.

Science.gov (United States)

Hou, X; Vuckovic, M; Buckley, K; Bénard, F; Schaffer, P; Ruth, T; Celler, A

2014-07-07

The cyclotron-based (100)Mo(p,2n)(99m)Tc reaction has been proposed as an alternative method for solving the shortage of (99m)Tc. With this production method, however, even if highly enriched molybdenum is used, various radioactive and stable isotopes will be produced simultaneously with (99m)Tc. In order to optimize reaction parameters and estimate potential patient doses from radiotracers labeled with cyclotron produced (99m)Tc, the yields for all reaction products must be estimated. Such calculations, however, are extremely complex and time consuming. Therefore, the objective of this study was to design a graphical user interface (GUI) that would automate these calculations, facilitate analysis of the experimental data, and predict dosimetry. The resulting GUI, named Cyclotron production Yields and Dosimetry (CYD), is based on Matlab®. It has three parts providing (a) reaction yield calculations, (b) predictions of gamma emissions and (c) dosimetry estimations. The paper presents the outline of the GUI, lists the parameters that must be provided by the user, discusses the details of calculations and provides examples of the results. Our initial experience shows that the proposed GUI allows the user to very efficiently calculate the yields of reaction products and analyze gamma spectroscopy data. However, it is expected that the main advantage of this GUI will be at the later clinical stage when entering reaction parameters will allow the user to predict production yields and estimate radiation doses to patients for each particular cyclotron run.

Commercial and PET radioisotope manufacturing with a medical cyclotron

International Nuclear Information System (INIS)

Boothe, T.E.; McLeod, T.F.; Plitnikas, M.; Kinney, D.; Tavano, E.; Feijoo, Y.; Smith, P.; Szelecsenyi, F.

1993-01-01

Mount Sinai has extensive experience in producing radionuclides for commercial sales and for incorporation into radiopharmaceuticals, including PET. Currently, an attempt is being made to supply radiochemicals to radiopharmaceutical manufacturers outside the hospital, to prepare radiopharmaceuticals for in-house use, and to prepare PET radiopharmaceuticals, such as 2-[F-18] FDG, for outside sales. This use for both commercial and PET manufacturing is atypical for a hospital-based cyclotron. To accomplish PET radiopharmaceutical sales, the hospital operates a nuclear pharmacy. A review of operational details for the past several years shows a continuing dependence on commercial sales which is reflected in research and developmental aspects and in staffing. Developmental efforts have centered primarily on radionuclide production, target development, and radiochemical processing optimization. (orig.)

Commercial and PET radioisotope manufacturing with a medical cyclotron

Science.gov (United States)

Boothe, T. E.; McLeod, T. F.; Plitnikas, M.; Kinney, D.; Tavano, E.; Feijoo, Y.; Smith, P.; Szelecsényi, F.

1993-06-01

Mount Sinai has extensive experience in producing radionuclides for commercial sales and for incorporation into radiopharmaceuticals, including PET. Currently, an attempt is being made to supply radiochemicals to radiopharmaceutical manufacturers outside the hospital, to prepare radiopharmaceuticals for in-house use, and to prepare PET radiopharmaceuticals, such as 2-[F-18] FDG, for outside sales. This use for both commercial and PET manufacturing is atypical for a hospital-based cyclotron. To accomplish PET radiopharmaceutical sales, the hospital operates a nuclear pharmacy. A review of operational details for the past several years shows a continuing dependence on commercial sales which is reflected in research and developmental aspects and in staffing. Developmental efforts have centered primarily on radionuclide production, target development, and radiochemical processing optimization.

Production of radionuclides by 14 MeV neutron generator

International Nuclear Information System (INIS)

Alfassi, Z.B.

1983-01-01

Due to the short half-lives of these nuclides they have to be produced in situ or at least not far from the place of use. The cost of 14 MeV neutron generators have been compared with the typical middle-sized cyclotrons and it was found that the capital costs are much lower in the case of neutron generators. This is the main reason for the availability of 14 MeV neutron generators in many scientific institutes compared to the scarcity of cyclotrons. Lately, the use of 14 MeV neutrons for cancer therapy was studied in several medical centers. A number of hospitals and cancer research centers have high intensity 14 MeV neutron generators for this purpose. The advantages of using short-lived in-house produced radionuclides suggest the use of the available 14 MeV neutron generators for biological studies and in medical diagnosis. 14 MeV neutron generators can be used to produce some of the medically useful radionuclides, such as /sup 18/F, /sup 80/Br, /sup 199m/Hg, and others. However, the amount required for medicine can only be prepared by the new high intensity neutron generators, used for neutron therapy and not by the smaller ones, commonly used in university laboratories (--10/sup 11/ n/sec). On the other hand, these relatively small neutron generators can be used for the preparation of radionuclides for biological studies. They facilitate the study of metabolism of elements for which radionuclides cannot be usually purchased due to short half-lives or the high price of the long-lived ones, such as /sup 34m/Cl, /sup 18/F, /sup 28,29/Al, /sup 27/Mg, and others. An example is the work done on the fate of Al and Mg in rats using /sup 28/Al and /sup 27/Mg./sup 13/

Accelerator based Production of Auger-Electron-emitting Isotopes for Radionuclide Therapy

DEFF Research Database (Denmark)

Thisgaard, Helge

Sb from the enriched 119Sn target material with high radionuclidic- and chemical purity. A method that also allows efficient recovery of the 119Sn for recycling. To demonstrate the ability of producing therapeutic quantities of 119Sb and other radioisotopes for therapy with a low-energy cyclotron...... isotopes (e.g. 119Sb or 64Cu) using the PETtrace cyclotron commonly found at the larger PET-centers in the hospitals. Finally, research in a new method to measure the radiotoxicity of Auger-emitters invitro using cellular microinjection has been carried out. The purpose of this method is to be able...

Short-lived cyclotron-produced radioisotopes: Medi-Physics, Inc.'s commitment

International Nuclear Information System (INIS)

Kramer, H.H.

1985-01-01

Medi-Physics, Inc., is a major US supplier of short-lived cyclotron-produced radioisotopes for radiopharmaceuticals, as well as routinely producing and distributing the greatest number of 123 I radiopharmaceuticals. The present commercial production capacity for 123 I is more than ten times the theoretical need for existing procedures and is more than adequate for the research and development of new radiopharmaceuticals. However, production capacity is only one component of many that are required to supply a radioisotope for human use. These components are summarized in this paper

Possibilities of 140Nd production by the VINCY cyclotron

International Nuclear Information System (INIS)

Comor, J.J.; Dakovic, M.

2000-01-01

Application of positron emission tomography (PET) in modern medical diagnosis relies on the application of short lived radionuclides 11 C, 13 N, 15 O and 18 F, presuming their production in the close vicinity of the PET camera. Application of long-lived positron emitters would enable the regional distribution of PET radiopharmaceuticals, which would significantly lower the price of PET diagnosis, as well as enable its application in fields currently inhibited by the short half-life of available positron emitters. One of the candidates for application in PET is the generator system 140 Nd/ 140 Pr, due to the long half-life of 140 Nd (3,37 days). Theoretical calculations confirm that this radionuclide can be produced with high yields by protons accelerated to energies bellow 30 MeV. Due to its optimal operating parameters, the VINCY Cyclotron could produce enough 140 Nd for its regional distribution to a number of PET centers (author)

Proposal on ''standardized high current solid targets for cyclotron production of diagnostic and therapeutic radionuclides''

International Nuclear Information System (INIS)

Suparman, Ibon

2000-01-01

The Center for the Development of Radioisotopes and Radiopharmaceuticals - National Nuclear Energy Agency (P2RR-BATAN) has one Cyclotron type CS-30 with maximum 30 MeV proton energy. It is used since 1990 for 201 Tl production. The main use of 201 Tl in Indonesia is for diagnosis and assessment of myocardial ischaemia, especially diagnosis of coronary artery disease, viability of the heart muscle and forecasting the outcome for patients with coronary disease. The Cyclotron facility is supported with a solid target station, two hot cells and the chemical equipment for electroplating. The yield of 201 Tl production currently achieved around 40-50%. The irradiation technique and chemical separation should be improved. We are also very interested in the development of the production of 103 Pd via 103 Rh (p,n) 103 Pd reaction. The objective of this proposal will support the main program of the National Nuclear Energy Agency (BATAN) in enhancement of health care and in providing Cyclotron produced radiopharmaceuticals for hospitals

Medical Cyclotrons

Science.gov (United States)

Friesel, D. L.; Antaya, T. A.

Particle accelerators were initially developed to address specific scientific research goals, yet they were used for practical applications, particularly medical applications, within a few years of their invention. The cyclotron's potential for producing beams for cancer therapy and medical radioisotope production was realized with the early Lawrence cyclotrons and has continued with their more technically advanced successors — synchrocyclotrons, sector-focused cyclotrons and superconducting cyclotrons. While a variety of other accelerator technologies were developed to achieve today's high energy particles, this article will chronicle the development of one type of accelerator — the cyclotron, and its medical applications. These medical and industrial applications eventually led to the commercial manufacture of both small and large cyclotrons and facilities specifically designed for applications other than scientific research.

Study of solid target preparation for developing I-124, Pd-103, Cu-64 radioisotopes based cyclotron

Energy Technology Data Exchange (ETDEWEB)

Kim, Jae Hong; Park, Hyun; Lee, Ji Sub; Lee, Dong Hoon; Chun, Kwon Soo [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Choi, Hee Dong [Seoul National Univ., Seoul (Korea, Republic of)

2005-07-01

The decay characteristics of I-124, Pd-103 and Cu-64 radioisotopes produced by cyclotron have considered useful agents for diagnostic imaging or therapy. Numbers of radioisotopes used in medical applications or promised for development are produced with solid targets. The aims of developing solid targets are to obtain large quantities of radionuclides from accelerators. The scope of the study is to develop optimized target system and chemical procedures of these radioisotopes. In order to increase the availability of the radionuclides, the investigation for the design of the solid target and different procedures yielding efficient production of high specific activity will be carrying. In this work, we will present the issue of the primary target design concept.

Accurate Monte Carlo modeling of cyclotrons for optimization of shielding and activation calculations in the biomedical field

Science.gov (United States)

Infantino, Angelo; Marengo, Mario; Baschetti, Serafina; Cicoria, Gianfranco; Longo Vaschetto, Vittorio; Lucconi, Giulia; Massucci, Piera; Vichi, Sara; Zagni, Federico; Mostacci, Domiziano

2015-11-01

Biomedical cyclotrons for production of Positron Emission Tomography (PET) radionuclides and radiotherapy with hadrons or ions are widely diffused and established in hospitals as well as in industrial facilities and research sites. Guidelines for site planning and installation, as well as for radiation protection assessment, are given in a number of international documents; however, these well-established guides typically offer analytic methods of calculation of both shielding and materials activation, in approximate or idealized geometry set up. The availability of Monte Carlo codes with accurate and up-to-date libraries for transport and interactions of neutrons and charged particles at energies below 250 MeV, together with the continuously increasing power of nowadays computers, makes systematic use of simulations with realistic geometries possible, yielding equipment and site specific evaluation of the source terms, shielding requirements and all quantities relevant to radiation protection. In this work, the well-known Monte Carlo code FLUKA was used to simulate two representative models of cyclotron for PET radionuclides production, including their targetry; and one type of proton therapy cyclotron including the energy selection system. Simulations yield estimates of various quantities of radiological interest, including the effective dose distribution around the equipment, the effective number of neutron produced per incident proton and the activation of target materials, the structure of the cyclotron, the energy degrader, the vault walls and the soil. The model was validated against experimental measurements and comparison with well-established reference data. Neutron ambient dose equivalent H*(10) was measured around a GE PETtrace cyclotron: an average ratio between experimental measurement and simulations of 0.99±0.07 was found. Saturation yield of 18F, produced by the well-known 18O(p,n)18F reaction, was calculated and compared with the IAEA recommended

Experimental study and nuclear model calculations on the $^{192}Os (p, n)^{192}$Ir reaction Comparison of reactor and cyclotron production of the therapeutic radionuclide $^{192}$Ir

CERN Document Server

Hilgers, K; Sudar, S; 10.1016/j.apradiso.2004.12.010

2005-01-01

In a search for an alternative route of production of the important therapeutic radionuclide /sup 192/Ir (T/sub 1/2/=78.83 d), the excitation function of the reaction /sup 192/Os(p, n)/sup 192/Ir was investigated from its threshold up to 20MeV. Thin samples of enriched /sup 192/Os were obtained by electrodeposition on Ni, and the conventional stacked-foil technique was used for cross section measurements. The experimental data were compared with the results of theoretical calculations using the codes EMPIRE-II and ALICE-IPPE. Good agreement was found with EMPIRE-II, but slightly less with the ALICE-IPPE calculations. The theoretical thick target yield of /sup 192/Ir over the energy range E/sub p/=16 to 8MeV amounts to only 0.16MBq/ mu A.h. A comparison of the reactor and cyclotron production methods is given. In terms of yield and radionuclidic purity of /sup 192/Ir the reactor method appears to be superior; the only advantage of the cyclotron method could be the higher specific activity of the product.

Operational experience and recent developments at the National Medical Cyclotron, Sydney

International Nuclear Information System (INIS)

Conard, E.M.; Arnott, D.W.

1996-01-01

The National Medical Cyclotron, Sydney, Australia commenced operation in mid 1991, with a mission to provide PET and SPECT radionuclides throughout Australia. The realization of the present production capacity has been synonymous with the development of the facility's industrial cyclotron (IBA Cyclone 30). The choice of cyclotron was based on the Cyclone 30's virtues as a compact, user-friendly, energy efficient cyclotron, offering the beam quality characteristic of negative ion technology. Development of the cyclotron has improved reliability and increased beam capacity, while improvements to targetry have increased production reliability. More recently, the installation and commissioning of a new solid target irradiation facility has provided much needed redundancy. This paper describes the major cyclotron and targetry developments carried out to date. (orig.)

Advances in intense beams, beam delivery, targetry, and radiochemistry at advanced cyclotron systems

Energy Technology Data Exchange (ETDEWEB)

Johnson, R.R. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada)]. E-mail: djohnson@advancedcyclotron.com; Watt, R. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada); Kovac, B. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada); Zyuzin, A. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada); Van Lier, E. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada); Erdman, K.L. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada); Gyles, Wm. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada); Sabaiduc, V. [Advanced Cyclotron Systems Inc., 7851 Alderbridge Way, Richmond, BC, V6X 2A4 (Canada); McQuarrie, S.A. [Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, T6G 1Z2 (Canada); Wilson, J. [Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, T6G 1Z2 (Canada); Backhouse, C. [Department of Electrical Engineering, University of Alberta, Edmonton, AB (Canada); Gelbart, Wm. [Advanced System Design, C22, S6, RR1, Garden Bay, BC, V0N 1S0 (Canada); Kuo, T. [4654 N. Larwin Ave., Concorde, CA 94521 United States (United States)

2007-08-15

The increasing demand for radionuclides for PET and SPECT has resulted in ACSI system improvements starting from the cyclotron and proceeding to the Radiochemistry Modules. With more TR30 cyclotrons installed and operating at full capacity, emphasis has been placed on improving the operational components to reduce both the incidence of failure and subsequent maintenance time. A cyclotron system has been developed that meets the needs of a regional radiopharmacy that supplies both positron and single photon emitters that would not otherwise be available. This new system has been named the TR24. In order to deal with some of the challenges of high currents, a method has been developed for passivating the entrance window foil during high current irradiation of a water target used to produce F-18. A method has been developed for passivating the entrance window foil to reduce unwanted chemical species that interfere with radiopharmaceutical production. Preliminary results for novel radioiodine production technique using the TR19/9 are also discussed.

Advances in intense beams, beam delivery, targetry, and radiochemistry at advanced cyclotron systems

Science.gov (United States)

Johnson, R. R.; Watt, R.; Kovac, B.; Zyuzin, A.; Van Lier, E.; Erdman, K. L.; Gyles, Wm.; Sabaiduc, V.; McQuarrie, S. A.; Wilson, J.; Backhouse, C.; Gelbart, Wm.; Kuo, T.

2007-08-01

The increasing demand for radionuclides for PET and SPECT has resulted in ACSI system improvements starting from the cyclotron and proceeding to the Radiochemistry Modules. With more TR30 cyclotrons installed and operating at full capacity, emphasis has been placed on improving the operational components to reduce both the incidence of failure and subsequent maintenance time. A cyclotron system has been developed that meets the needs of a regional radiopharmacy that supplies both positron and single photon emitters that would not otherwise be available. This new system has been named the TR24. In order to deal with some of the challenges of high currents, a method has been developed for passivating the entrance window foil during high current irradiation of a water target used to produce F-18. A method has been developed for passivating the entrance window foil to reduce unwanted chemical species that interfere with radiopharmaceutical production. Preliminary results for novel radioiodine production technique using the TR19/9 are also discussed.

Advances in intense beams, beam delivery, targetry, and radiochemistry at advanced cyclotron systems

International Nuclear Information System (INIS)

Johnson, R.R.; Watt, R.; Kovac, B.; Zyuzin, A.; Van Lier, E.; Erdman, K.L.; Gyles, Wm.; Sabaiduc, V.; McQuarrie, S.A.; Wilson, J.; Backhouse, C.; Gelbart, Wm.; Kuo, T.

2007-01-01

The increasing demand for radionuclides for PET and SPECT has resulted in ACSI system improvements starting from the cyclotron and proceeding to the Radiochemistry Modules. With more TR30 cyclotrons installed and operating at full capacity, emphasis has been placed on improving the operational components to reduce both the incidence of failure and subsequent maintenance time. A cyclotron system has been developed that meets the needs of a regional radiopharmacy that supplies both positron and single photon emitters that would not otherwise be available. This new system has been named the TR24. In order to deal with some of the challenges of high currents, a method has been developed for passivating the entrance window foil during high current irradiation of a water target used to produce F-18. A method has been developed for passivating the entrance window foil to reduce unwanted chemical species that interfere with radiopharmaceutical production. Preliminary results for novel radioiodine production technique using the TR19/9 are also discussed

Nuclear data relevant to the production and application of diagnostic radionuclides

International Nuclear Information System (INIS)

Qaim, S.M.

2002-01-01

The types of nuclear data and their quality required in the production and application of diagnostic radionuclides are outlined. The radioactive decay data determine the suitability of a radioisotope for in vivo tracer studies, both from the imaging and internal radiation dose considerations. The nuclear reaction cross section data allow optimisation of production routes. Both reactors and cyclotrons are used for production purposes. The nuclear data needed in the two cases and their present status are discussed. Special attention is paid to radionuclides suitable for emission tomography (PET and SPECT). The controversy about reactor vs cyclotron production of the widely used sup 9 sup 9 Mo/ sup 9 sup 9 sup m Tc generator system is discussed. Some special considerations in cyclotron production of radionuclides are outlined. The need of accurate data near reaction thresholds, the constraint of available particles and their energies at a small cyclotron, the influence of increasing incident particle energy, and the formation of isomeric impurities are discussed in detail. The role of nuclear model calculations in predicting unknown data is considered. (author)

Modern compact cyclotrons for nuclear medicine designed and manufactured in NIIEFA

International Nuclear Information System (INIS)

Bogdanov, P.V.; Vasilchenko, I.N.; Gavrish, Yu.N.; Galchuk, A.V.; Grigorenko, S.V.; Kuzhlev, A.N.; Menshov, Yu.D.; Mudroyubov, V.G.; Ponomarenko, V.I.; Strokach, A.P.

2012-01-01

A series of compact cyclotrons, the CC-12, CC-18/9 and MCC-30/15, intended for the production of radionuclides for diagnostics and therapy directly in medical institutions has been designed and manufactured in NIIEFA. These cyclotrons provide the acceleration of negative hydrogen and deuterium ions injected from external sources. Beams of accelerated particles are extracted by stripping negative ions to protons and deuterons by carbon foils. Shielding-type electromagnets with the vertically located median plane are applied in these cyclotrons.

Simple and effective method for nuclear tellurium isomers separation from antimony cyclotron targets

International Nuclear Information System (INIS)

Bondarevskij, S.I.; Eremin, V.V.

1999-01-01

Simple and effective method of generation of tellurium nuclear isomers from irradiated on cyclotron metallic antimony is suggested. Basically this method consists in consideration of the big difference in volatilities of metallic forms of antimony, tin and tellurium. Heating of the tin-antimony alloy at 1200 K permits to separate about 90 % of produced quantity of 121m Te and 123m Te (in this case impurity of antimony radionuclides is not more than 1 % on activity) [ru

Biomedical research with cyclotron-produced radionuclides. Progress report, August 1, 1982-July 31, 1983

International Nuclear Information System (INIS)

Laughlin, J.S.; Benua, R.S.; Gelbard, A.S.; Bigler, R.E.

1983-01-01

The contents include brief descriptions of the following research programs: an evaluation of chemotherapeutic regimens in solid tumors with N-13 labelled L-amino acids, studies of N-13 L-amino acid metabolism in vivo, and evaluation of N-13 labelled amino acids and ammonia for physiological studies of patients undergoing chemotherapy; biological studies with N-13 and C-11 labelled amino acids and ammonia; synthesis and development of N-13 and, C-11 labelled compounds; data analysis, modelling and instrumentation; and radionuclide production

Cyclotron Production of Technetium-99m

Science.gov (United States)

Gagnon, Katherine M.

Technetium-99m (99mTc) has emerged as the most widely used radionuclide in medicine and is currently obtained from a 99Mo/ 99mTc generator system. At present, there are only a handful of ageing reactors worldwide capable of producing large quantities of the parent isotope, 99Mo, and owing to the ever growing shutdown periods for maintenance and repair of these ageing reactors, the reliable supply 99mTc has been compromised in recent years. With an interest in alternative strategies for producing this key medical isotope, this thesis focuses on several technical challenges related to the direct cyclotron production of 99mTc via the 100Mo(p,2n)99mTc reaction. In addition to evaluating the 100Mo(p,2n)99mTc and 100Mo(p,x)99Mo reactions, this work presented the first experimental evaluation of the 100Mo(p,2n) 99gTc excitation function in the range of 8-18 MeV. Thick target calculations suggested that large quantities of cyclotron-produced 99mTc may be possible. For example, a 6 hr irradiation at 500 μA with an energy window of 18→10 MeV is expected to yield 1.15 TBq of 99mTc. The level of coproduced 99gTc contaminant was found to be on par with the current 99Mo/99mTc generator standard eluted with a 24 hr frequency. Highly enriched 100Mo was required as the target material for 99mTc production and a process for recycling of this expensive material is presented. An 87% recovery yield is reported, including metallic target preparation, irradiation, 99mTc extraction, molybdate isolation, and finally hydrogen reduction to the metal. Further improvements are expected with additional optimization experiments. A method for forming structurally stable metallic molybdenum targets has also been developed. These targets are capable of withstanding more than a kilowatt of beam power and the reliable production and extraction of Curie quantities of 99mTc has been demonstrated. With the end-goal of using the cyclotron-produced 99mTc clinically, the quality of the cyclotron-produced

Considerations, measurements and logistics associated with low-energy cyclotron decommissioning

International Nuclear Information System (INIS)

Sunderland, J. J.; Erdahl, C. E.; Bender, B. R.; Sensoy, L.; Watkins, G. L.

2012-01-01

The University of Iowa’s 20-year-old 17 MeV Scanditronix cyclotron underwent decommissioning in the summer of 2011. To satisfy local, state and federal regulations defining removal, transportation and long-term safe and environmentally secure disposal of the 22 ton activated cyclotron, a series of nuclear spectroscopic measurements were performed to characterize the nature and extent of proton and neutron activation of the 22-ton cyclotron, its associated targets, and the concrete wall that was demolished to remove the old cyclotron. Neutron activation of the concrete wall was minimal and below exempt concentrations resulting in standard landfill disposal. The cyclotron assessment revealed the expected array of short and medium-lived radionuclides. Subsequent calculations suggest that meaningful levels residual activity will have decayed virtually to background after 15 years, with the total residual activity of the entire cyclotron dropping below 37 MBq (1 mCi).

Target development for 67Cu, 82Sr radionuclide production at the RIC-80 facility

Science.gov (United States)

Panteleev, V. N.; Barzakh, A. E.; Batist, L. Kh.; Fedorov, D. V.; Ivanov, V. S.; Krotov, S. A.; Molkanov, P. L.; Moroz, F. V.; Orlov, S. Yu.; Volkov, Yu. M.

2018-01-01

A high-current cyclotron C-80 capable of producing 40-80 MeV proton beams with a current of up to 200 μA has been constructed and commissioned at PNPI (Petersburg Nuclear Physics Institute). One of the main goals of cyclotron C-80 is the production of a wide spectrum of medical radionuclides for diagnostics and therapy. To date, the project development of a radioisotope facility RIC-80 (radioisotopes at cyclotron C-80) has been completed. The feature of the project is the use of a mass-separator combined with the ion-target device for obtaining ion beams of radioisotopes with a high purity of separation that is especially important for medical applications. The first results of a new high-temperature method for extracting 82Sr and 67Cu radioisotopes from irradiated targets have been presented.

Study of the half-life of 123I and the determination of possible radionuclidic impurities

International Nuclear Information System (INIS)

Delgado, Jose Ubiratan; Araujo, Miriam Taina Ferreira de; Silva, Carlos Jose da; Araujo, Camila Cristina Cunha; Candido, Marcos Antonio; Pereira, Wagner do Prado

2013-01-01

During the process of production of the radiopharmaceutical nuclear reactor or cyclotron, impurities can be generated from biological, chemical and radionuclidic. The development of the present work was to study the half-life of Na 123 I sample produced in IEN (Institute of Nuclear Engineering) using the technique of gamma-ray spectrometry with germanium detector in order to Identify such impurities. The results Indicate values of half-life consistent with recent publications with a deviation of 0,08% and 0:11% of uncertainty as well as the identification of impurities to radionuclides 95m Tc, 96 Tc and 121 Te. (author)

Concepts and strategies to establish a cyclotron/PET center

International Nuclear Information System (INIS)

Hernan Vera Ruiz; D, Ph.

2004-01-01

detailed cost/benefit and market potential analysis, a thorough comparative evaluation of the available technologies in the market and their costs, and finally, a realistic assessment of the human and financial resources available, for facilities of this type are long term commitments for governments or private institutions. The definition of the utilization programme necessarily has to derive from the definition of the mission statement of the facility as well as after having close consultations with the nuclear medicine community as users of the PET products. The current needs of the nuclear medicine community for cyclotron produced radionuclides are by large satisfied with a reliable production of the four classical PET radionuclides tracers, e.g. F-18, N-13, O-15 and C-11 and a few of their corresponding radiopharmaceuticals, most notably, F-18FDG, the most commonly used PET radiopharmaceutical in the world today. For this situation, the industry offers a wide variety of cyclotrons with special features optimized for a reliable and prolific production programme. The presentation will provide examples and suggestions for advanced planning and project structure, define the critical steps that need careful consideration to avoid pitfalls, as well as for actual project implementation and management. (authors)

A solvent-extraction module for cyclotron production of high-purity technetium-99m.

Science.gov (United States)

Martini, Petra; Boschi, Alessandra; Cicoria, Gianfranco; Uccelli, Licia; Pasquali, Micòl; Duatti, Adriano; Pupillo, Gaia; Marengo, Mario; Loriggiola, Massimo; Esposito, Juan

2016-12-01

The design and fabrication of a fully-automated, remotely controlled module for the extraction and purification of technetium-99m (Tc-99m), produced by proton bombardment of enriched Mo-100 molybdenum metallic targets in a low-energy medical cyclotron, is here described. After dissolution of the irradiated solid target in hydrogen peroxide, Tc-99m was obtained under the chemical form of 99m TcO 4 - , in high radionuclidic and radiochemical purity, by solvent extraction with methyl ethyl ketone (MEK). The extraction process was accomplished inside a glass column-shaped vial especially designed to allow for an easy automation of the whole procedure. Recovery yields were always >90% of the loaded activity. The final pertechnetate saline solution Na 99m TcO 4 , purified using the automated module here described, is within the Pharmacopoeia quality control parameters and is therefore a valid alternative to generator-produced 99m Tc. The resulting automated module is cost-effective and easily replicable for in-house production of high-purity Tc-99m by cyclotrons. Copyright © 2016 Elsevier Ltd. All rights reserved.

Naturally Occurring Radionuclides in Pottery, Ceramic and Glasswares Produced in Bangladesh

International Nuclear Information System (INIS)

Chowdhury, M.I.; Reaz, Rafia; Kamal, M.; Alam, M.N.; Mustafa, M.N.

2005-01-01

The concentrations of naturally occurring radionuclides were measured using gamma spectrometry in the finished products of pottery, glass, ceramic and tiles. Ceramic and pottery utensils, tiles, basin and glassware contained naturally occurring radionuclides. Pottery is produced from local clay materials, but ceramic, tiles, basin and glassware's are made from both local and imported raw materials. Radium and thorium radionuclides are concentrated during the making of pottery from the clay materials due to calcination. Radionuclides concentrated more in the highly calcined pottery products than the low calcined products. Glassware products contained very low quantities of radionuclides comparing with the ceramic and pottery products. Study on radioactivity in the pottery, ceramic and glassware products is important in the assessment of possible radiological hazards to human health. The knowledge is essential for the development of standards and guidelines for the use and management of these materials. (author)

Accelerator based production of auger-electron-emitting isotopes for radionuclide therapy

International Nuclear Information System (INIS)

Thisgaard, H.

2008-08-01

In this research project the focus has been on the identification and production of new, unconventional Auger-electron-emitting isotopes for targeted radionuclide therapy of cancer. Based on 1st principles dosimetry calculations on the subcellular level, the Auger-emitter 119Sb has been identified as a potent candidate for therapy. The corresponding imaging analogue 117Sb has been shown from planar scintigraphy and single-photon emission computed tomography (SPECT) to be suitable for SPECT-based dosimetry of a future Sb-labeled radiopharmaceutical. The production method of these radioisotopes has been developed using a low-energy cyclotron via the nuclear reactions 119Sn(p,n)119Sb and 117Sn(p,n)117Sb including measurements of the excitation function for the former reaction. Moreover, a new high-yield radiochemical separation method has been developed to allow the subsequent separation of the produced 119Sb from the enriched 119Sn target material with high radionuclidic- and chemical purity. A method that also allows efficient recovery of the 119Sn for recycling. To demonstrate the ability of producing therapeutic quantities of 119Sb and other radioisotopes for therapy with a low-energy cyclotron, two new 'High Power' cyclotron targets were developed in this study. The target development was primarily based on theoretical thermal modeling calculations using finite-element-analysis software. With these targets, I have shown that it will be possible to produce several tens of GBq of therapeutics isotopes (e.g. 119Sb or 64Cu) using the PETtrace cyclotron commonly found at the larger PET-centers in the hospitals. Finally, research in a new method to measure the radiotoxicity of Auger-emitters invitro using cellular microinjection has been carried out. The purpose of this method is to be able to experimentally evaluate and compare the potency of the new and unconventional Auger-emitters (e.g. 119Sb). However, due to experimental complications, the development of this

Accelerator based production of auger-electron-emitting isotopes for radionuclide therapy

Energy Technology Data Exchange (ETDEWEB)

Thisgaard, H.

2008-08-15

In this research project the focus has been on the identification and production of new, unconventional Auger-electron-emitting isotopes for targeted radionuclide therapy of cancer. Based on 1st principles dosimetry calculations on the subcellular level, the Auger-emitter 119Sb has been identified as a potent candidate for therapy. The corresponding imaging analogue 117Sb has been shown from planar scintigraphy and single-photon emission computed tomography (SPECT) to be suitable for SPECT-based dosimetry of a future Sb-labeled radiopharmaceutical. The production method of these radioisotopes has been developed using a low-energy cyclotron via the nuclear reactions 119Sn(p,n)119Sb and 117Sn(p,n)117Sb including measurements of the excitation function for the former reaction. Moreover, a new high-yield radiochemical separation method has been developed to allow the subsequent separation of the produced 119Sb from the enriched 119Sn target material with high radionuclidic- and chemical purity. A method that also allows efficient recovery of the 119Sn for recycling. To demonstrate the ability of producing therapeutic quantities of 119Sb and other radioisotopes for therapy with a low-energy cyclotron, two new 'High Power' cyclotron targets were developed in this study. The target development was primarily based on theoretical thermal modeling calculations using finite-element-analysis software. With these targets, I have shown that it will be possible to produce several tens of GBq of therapeutics isotopes (e.g. 119Sb or 64Cu) using the PETtrace cyclotron commonly found at the larger PET-centers in the hospitals. Finally, research in a new method to measure the radiotoxicity of Auger-emitters invitro using cellular microinjection has been carried out. The purpose of this method is to be able to experimentally evaluate and compare the potency of the new and unconventional Auger-emitters (e.g. 119Sb). However, due to experimental complications, the development

Biomedical research with cyclotron produced radionuclides

Energy Technology Data Exchange (ETDEWEB)

Laughlin, J.S.; Benua, R.S.; Tilbury, R.S.

1979-09-01

Progress is reported on: metabolic and tumor localization in man and animals; radiodrug development; dosimetry for internally deposited isotopes; and radioactive material transfer system. Based on experience with /sup 13/N-glutamate in osteogenic sarcoma and Ewing's sarcoma, we conclude that (a) the /sup 13/N label enters tumor tissue rapidly at a rate similar to that at which activity leaves the blood, suggesting that the labeled glutamate itself is being transported into the tumor rather than some labeled metabolite; (b) uptake in the tumor is related to its metabolic activity, but factors such as blood flow are also important; (c) changes in the glutamate scan accurately reflect the response of osteogenic sarcoma to pre-operative chemotherapy as measured by conventional means, and that it is desirable to extend this experience to other types of tumors. /sup 13/N-Glutamate (and other /sup 13/N-labeled compounds) afford several advantages over conventional tumor imaging agents, such as rapid blood clearance and localization, low radiation exposure and the possibility of obtaining accurate, three-dimensional quantitative images via positron emission tomography. It is doubtful that these advantages will justify the routine use of /sup 13/N-glutamate to detect tumors or to monitor therapy except in clinical situations where conventional techniques are unsatisfactory. The value of /sup 1/3N-glutamate is as a tool to assess the metabolic requirement of neoplastic tissue in cancer patients in-vivo. (PCS)

Biomedical research with cyclotron produced radionuclides

International Nuclear Information System (INIS)

Laughlin, J.S.; Benua, R.S.; Tilbury, R.S.

1979-09-01

Progress is reported on: metabolic and tumor localization in man and animals; radiodrug development; dosimetry for internally deposited isotopes; and radioactive material transfer system. Based on experience with 13 N-glutamate in osteogenic sarcoma and Ewing's sarcoma, we conclude that (a) the 13 N label enters tumor tissue rapidly at a rate similar to that at which activity leaves the blood, suggesting that the labeled glutamate itself is being transported into the tumor rather than some labeled metabolite; (b) uptake in the tumor is related to its metabolic activity, but factors such as blood flow are also important; (c) changes in the glutamate scan accurately reflect the response of osteogenic sarcoma to pre-operative chemotherapy as measured by conventional means, and that it is desirable to extend this experience to other types of tumors. 13 N-Glutamate (and other 13 N-labeled compounds) afford several advantages over conventional tumor imaging agents, such as rapid blood clearance and localization, low radiation exposure and the possibility of obtaining accurate, three-dimensional quantitative images via positron emission tomography. It is doubtful that these advantages will justify the routine use of 13 N-glutamate to detect tumors or to monitor therapy except in clinical situations where conventional techniques are unsatisfactory. The value of 1 3N-glutamate is as a tool to assess the metabolic requirement of neoplastic tissue in cancer patients in-vivo

Assessment of the direct cyclotron production of (99m)Tc: An approach to crisis management of (99m)Tc shortage.

Science.gov (United States)

Rovais, Mohammad Reza Aboudzadeh; Aardaneh, Khosro; Aslani, Gholamreza; Rahiminejad, Ali; Yousefi, Kamran; Boulouri, Fatemeh

2016-06-01

Nowadays, the cyclotron production of technetium-99m ((99m)Tc) has been increased, due to the worldwide (99m)Tc generator shortage. In the present work, an improved strategy for the production of (99m)Tc, using the proton irradiation of the enriched (100)Mo was developed. The performance of this method in terms of the production yield, chemical purity, radiochemical purity, as well as radionuclide purity was evaluated. The average production yield was measured to be 356MBqμA(-1)h(-1). A good agreement was found between the calculated production yield and the experimental one. The radiochemical separation and total recovery yields of (99m)Tc were 92% and 69%, respectively. The radiochemical and the radionuclide purities of the (99m)Tc were 99% and >99.99% at the end of purification, respectively. The results of quality control tests (QC) support the concept that cyclotron-produced (99m)Tc is suitable for preparation of USP-compliant. Copyright © 2016 Elsevier Ltd. All rights reserved.

Method and apparatus for ion cyclotron spectrometry

Science.gov (United States)

Dahl, David A [Idaho Falls, ID; Scott, Jill R [Idaho Falls, ID; McJunkin, Timothy R [Idaho Falls, ID

2010-08-17

An ion cyclotron spectrometer may include a vacuum chamber that extends at least along a z-axis and means for producing a magnetic field within the vacuum chamber so that a magnetic field vector is generally parallel to the z-axis. The ion cyclotron spectrometer may also include means for producing a trapping electric field within the vacuum chamber that includes at least a first section that induces a first magnetron effect that increases a cyclotron frequency of an ion and at least a second section that induces a second magnetron effect that decreases the cyclotron frequency of an ion. The cyclotron frequency changes induced by the first and second magnetron effects substantially cancel one another so that an ion traversing the at least first and second sections will experience no net change in cyclotron frequency.

Status and perspectives at the cyclotron IFIN-HH Bucharest for diagnostic and therapeutic radionuclides production

International Nuclear Information System (INIS)

Dudu, Dorin; Racolta, Petru Mihai

2000-01-01

All the radioisotopes used in nuclear medicine are produced artificially using either a nuclear reactor or a cyclotron. By attaching suitable chemical labels to the radioisotopes, radiopharmaceuticals are obtained, which can be made to seek a desired organ by taking part in the metabolic processes. When radiopharmaceuticals are injected into the human body and specifically taken up by an organ of choice, a lack of uptake, or delay in uptake, denotes loss of function in the organ. There are 297 operating research reactors listed in the 1994 IAEA reactor database and this number has been declining over the last ten years. Of these, only 20-25 reactors have the appropriate performance specifications, appropriate operating schedules and the motivation to support the regular 7-day and regular 4-week schedules required for production of nuclides. In numerical terms, it can be argued that there is a vast global over-capacity of neutrons and target positions, but, in practice, the availability of such irradiation positions is significantly compromised by the reactors' own schedules and maintenance shutdowns. This capacity position will be gradually eroded over the next ten years, as many research reactors reach an age beyond which they become economically viable as research tools, and government-based funding programs disappear. Although the majority of the radioisotopes used in nuclear medicine have been produced from research reactors for over 45 years and the methods are generally well established, several new initiatives and developments have occurred recently. One example is 103 Pd which is one of the few accelerator generated isotopes to be in common use for therapy, in this case as a short-lived isotope for permanent implant treatment of prostate cancer. Historically, 103 Pd used to be generated via the 102 Pd(n,γ) 103 Pd reaction which relied on the availability of 1% naturally abundant 102 Pd, in an enriched form and its moderately high neutron capture cross

Short-lived radionuclide production capability at the Brookhaven Linac Isotope Producer

International Nuclear Information System (INIS)

Mausner, L.F.; Richards, P.

1985-01-01

The Brookhaven National Linac Isotope Producer is the first facility to demonstrate the capability of a large linear accelerator for efficient and economical production of difficult-to-make, medically useful radionuclides. The linac provides a beam of 200-MeV protons at an integrated beam current of up to 60 μA. The 200-MeV proton energy is very suitable for isotope production because the spallation process can create radionuclides unavailable at lower energy accelerators or reactors. Several medically important short-lived radionuclides are presently being prepared for on-site and off-site collaborative research programs. These are iodine-123, iron-52, manganese-52m, ruthenium-97, and the rubidium-81-krypton-81m system. The production parameters for these are summarized

Building on TR-24 success. Advanced Cyclotron Systems Inc. launches a new cyclotron model

International Nuclear Information System (INIS)

Russell Watt; William Gyles; Alexander Zyuzin

2015-01-01

ACSI is designing a new 30 MeV cyclotron based on the TR-24. While minimizing changes from the proven TR-24, including maintaining the same outer dimensions, the energy of the cyclotron will be increased to 30 MeV, which will make it the most compact, non-superconducting, 30 MeV cyclotron design to date. Maximum beam current will match the TR-24 at 1 mA. With the size and footprint of a typical low energy PET cyclotron, this system will offer users a cost effective solution for a diversified facility capable of producing a wide spectrum of PET and SPECT radioisotopes for research and commercial distribution. (author)

New irradiation facilities at the Australian national medical cyclotron

International Nuclear Information System (INIS)

Parcell, S.K.; Arnott, D.W.; Conard, E.M.

1999-01-01

Two new irradiation facilities have been developed at the National Medical Cyclotron for radionuclide production. The first relocates PET irradiations from the cyclotron vault to a dedicated PET beam room, to improve accessibility and reduce radiation exposures associated with target maintenance. This new facility consists of a beam line to transport 16-30 MeV proton beams from the cyclotron to 1 of 8 PET targets mounted on a target rack. The target rack has increased the number of targets available for production and experimentation. The second is a completely independent solid target irradiation facility for SPECT. This facility consists of a beam line to transport 26-30 MeV proton beams from the cyclotron to a dedicated beam room containing one solid target station. A new pneumatic target transfer system was also developed to transport the solid target to and from the existing chemistry hot cells. The beam line and target components are operated under the control of a dedicated PLC with a PC based user interface. The development and some technical aspects of these new irradiation facilities are discussed here. (author)

Medical cyclotron: why, where, how

International Nuclear Information System (INIS)

Scheer, Kurt; Comar, Dominique; Kellershohn, Claude

1976-01-01

Cyclotrons for medical purposes are particularly useful for the production of radioactive isotopes of elements normally constituting organic matter ( 15 O, 13 N, 11 C). The short half-life and positron emission of those elements are of great interest in medical diagnosis. Many others carrier-free radioisotopes can be produced by cyclotrons. Three categories of cyclotrons are mentioned. Desk top cyclotron only adapted to the production of short-lived radioisotopes in a hospital; low energy and average energy cyclotrons which require well-entrained personnel for their operation and are best adapted to the production of radioelements on a regional or even national scale. Examples relative to the interest of short-lived radioisotopes in lung and brain investigations and tumor detection are given

Cyclotron Produced Radionuclides for Diagnosis and Therapy of Human Neoplasms

Energy Technology Data Exchange (ETDEWEB)

Steven Larson MD

2009-09-21

This project funded since 1986 serves as a core project for cancer research throughout MSKCC, producing key radiotracers as well as basic knowledge about thel physics of radiation decay and imaging, for nuclear medicine applications to cancer diagnosis and therapy. In recent years this research application has broadened to include experiments intended to lead to an improved understanding of cancer biology and into the discovery and testing of new cancer drugs. Advances in immune based radiotargeting form the basis for this project. Both antibody and cellular based immune targeting methods have been explored. The multi-step targeting methodologies (MST) developed by NeoRex (Seattle,Washington), have been adapted for use with positron emitting isotopes and PET allowing the quantification and optimization of targeted delivery. In addition, novel methods for radiolabeling immune T-cells with PET tracers have advanced our ability to track these cells of prolonged period of time.

Improved High Current Liquid and Gas Targets for Cyclotron Produced Radioisotopes (Turkey)

Energy Technology Data Exchange (ETDEWEB)

Kivrakdal, Deniz; Ustaoğlu, Özgur; Soylu, Ayfer [Eczacibasi Nuclear Products Inc. (Turkey)

2009-07-01

As positron emitting radiopharmaceuticals gain interest in nuclear medicine, more and more baby cyclotrons are installed. The number of cyclotrons in Turkey went up to nine whereas the number of PET or PET/CT cameras increased more than 50% within a year. At the moment there are 65 positron imaging cameras serving a population of around 70 million. Eczacıbası - Monrol Nuclear Products Industry and Trade Inc. has five cyclotrons three of them being of different brands. In this report production data collected with these cyclotrons using high current liquid targets of silver, tantalum and niobium will be presented. The data presented here covers the whole duration of the project. Another topic which will be discussed here is the work carried out about purification and analysis of used O-18 water for re-use purposes. (author)

Improved High Current Liquid and Gas Targets for Cyclotron Produced Radioisotopes (Turkey)

International Nuclear Information System (INIS)

Kivrakdal, Deniz; Ustaoğlu, Özgur; Soylu, Ayfer

2009-01-01

As positron emitting radiopharmaceuticals gain interest in nuclear medicine, more and more baby cyclotrons are installed. The number of cyclotrons in Turkey went up to nine whereas the number of PET or PET/CT cameras increased more than 50% within a year. At the moment there are 65 positron imaging cameras serving a population of around 70 million. Eczacıbası - Monrol Nuclear Products Industry and Trade Inc. has five cyclotrons three of them being of different brands. In this report production data collected with these cyclotrons using high current liquid targets of silver, tantalum and niobium will be presented. The data presented here covers the whole duration of the project. Another topic which will be discussed here is the work carried out about purification and analysis of used O-18 water for re-use purposes. (author)

Routine production of 18F using 16.5 MeV cyclotron for synthesis of 2-(18F)fluro-2-deoxy-d-glucose (FDG)

International Nuclear Information System (INIS)

Abd Jalil Abd Hamid; Soni, P.S.; Rajan, M.G.R.

2006-01-01

A medium energy cyclotron with maximum of 75 mA beam current is capable of producing most common Positron Emission Tomography (PET) radionuclides in sufficient quantities. The cyclotron has two targets for production of Flourine-18. One is high yield target system (HYT) (1.2 mL) and the other is HYT Generation II (Gen-II) (2.2 mL) and capable of producing 110 and 170 GBq respectively. Enriched 18 O water (>95%) is used for the routine production of Flourine-18 using the 18 O(p,n) 18 F nuclear reaction and irradiated under helium gas pressurized at 59-65 kPa at a beam current of 35 mA - 55 mA for 20-67 minutes. The [ 18 F]fluoride ion produced are used for the synthesis of 2-fluoro-2-deoxy-D-glucose (2-[ 18 F]FDG). Various factors that may effect the production of PET radionuclides and one such factor includes the silver target body often introduce impurity such as silver oxides in form of black particles that can impede the (ID 0.75 mm) delivery line. Such contaminants would reduce the quantity of the available useful radioisotopes, and hinder the subsequent radiopharmaceutical processes. Used of HYT and HYT Gen-II for the routine production of 18 F- in few ten GBq quantities were reported

Determination of naturally occurring radionuclides in scales produced in oil industry

Energy Technology Data Exchange (ETDEWEB)

Al-Masri, M S; Ali, A F; Kitue, M; Kawash, A [Atomic Energy Commission, Dept. of Radiation Protection and Nuclear Safety, Damascus (Syrian Arab Republic)

1997-04-01

Scales produced by Oil production operations contain relatively high concentrations of natural radionuclides especially radium isotopes (Ra-226, Ra-228, Ra-224) and their daughters. These scales deposit in oil surface equipment such as separator tanks, tubular, and storage tanks. In this work, naturally occurring radionuclides and radiation exposure levels in some Syrian oil lines have been determined. Radiation measurements have shown high radiation exposure in some production sites and reached about 23 {mu}Sv/hr (production wellhead) which is higher than the normal background (0.09 - 012 {mu}Sv/hr). The highest value of the exposure around storage tanks was about o.5 {mu}Sv/hr. Moreover, the highest concentration of radionuclides in scales were found to be 47000 Bq/Kg and 55000 Bq/Kg for Ra-226 and Ra-228 respectively while in sludge samples, the Ra-226 concentration was about 24.2 Bq/Kg, a relatively very low activity. In addition, results have shown that soil contamination can occur by disposal of produced water to the surrounding environment. Furthermore, the present paper shows some of protection procedures, which should be followed by workers for radiation protection. (author). 10 refs., 4 tabs.

Cyclotrons and positron emitting radiopharmaceuticals

International Nuclear Information System (INIS)

Wolf, A.P.; Fowler, J.S.

1984-01-01

The state of the art of Positron Emission Tomography (PET) technology as related to cyclotron use and radiopharmaceutical production is reviewed. The paper discusses available small cyclotrons, the positron emitters which can be produced and the yields possible, target design, and radiopharmaceutical development and application. 97 refs., 12 tabs

Worldwide dispersion and deposition of radionuclides produced in atmospheric tests.

Science.gov (United States)

Bennett, Burton G

2002-05-01

Radionuclides produced in atmospheric nuclear tests were widely dispersed in the global environment. From the many measurements of the concentrations in air and the deposition amounts, much was learned of atmospheric circulation and environmental processes. Based on these results and the reported fission and total yields of individual tests, it has been possible to devise an empirical model of the movement and residence times of particles in the various atmospheric regions. This model, applied to all atmospheric weapons tests, allows extensive calculations of air concentrations and deposition amounts for the entire range of radionuclides produced throughout the testing period. Especially for the shorter-lived fission radionuclides, for which measurement results at the time of the tests are less extensive, a more complete picture of levels and isotope ratios can be obtained, forming a basis for improved dose estimations. The contributions to worldwide fallout can be inferred from individual tests, from tests at specific sites, or by specific countries. Progress was also made in understanding the global hydrological and carbon cycles from the tritium and 14C measurements. A review of the global measurements and modeling results is presented in this paper. In the future, if injections of materials into the atmosphere occur, their anticipated motions and fates can be predicted from the knowledge gained from the fallout experience.

Cyclotrons and positron emitting radiopharmaceuticals

Energy Technology Data Exchange (ETDEWEB)

Wolf, A.P.; Fowler, J.S.

1984-01-01

The state of the art of Positron Emission Tomography (PET) technology as related to cyclotron use and radiopharmaceutical production is reviewed. The paper discusses available small cyclotrons, the positron emitters which can be produced and the yields possible, target design, and radiopharmaceutical development and application. 97 refs., 12 tabs. (ACR)

Cyclotrons in developing countries

International Nuclear Information System (INIS)

Vera Ruiz, Hernan

2004-01-01

Cyclotron accelerators are prolific sources of charged particle for the production of radionuclides and have become an essential tool in the practice of modern nuclear medicine by providing reliable radiotracers for SPECT and PET studies. In a recent survey conducted by the IAEA in 2001, the growth in the number of cyclotron facilities installed in laboratories and hospitals in developed as well as developing countries was recorded. This trend, which started in the late 70's, continues in the present time also and all indications are that it will continue in the next five to ten years. The reasons for this growth are several: technology involved has become more user or 'hospital friendly', third party reimbursement for several clinical studies based on F-18 PET radiopharmaceuticals at least in some of the advanced countries started in 1998 and above all, the clear irrefutable and demonstrable conclusion of the positive cost/benefit outcomes of PET studies in the field of oncology to a lesser degree, thus far, for cardiology and neurology. It is however recognizable that the overall financial cost of the technology, which comprises the premises to house the facility, the cyclotron accelerator, the corresponding radiochemistry and quality control equipment and the PET cameras can be nevertheless an expensive proposition that requires careful advance planning. This fact is even more relevant when the facility is planned for installation in a developing country, which, frequently, in addition to having a lack of sufficient financial resources, do have shortage of qualified human resources to efficiently run the facility. In spite of the above, it is fact that more and more public as well as private organizations in the developing countries are setting up cyclotron/PET programmes or are seriously considering the installation of such a facility

Solid targets and irradiation facilities for production of diagnostic and therapeutic radionuclides at the Debrecen cyclotron

International Nuclear Information System (INIS)

Tarkanyi, F.; Ando, L.; Szucs, Z.; Mahunka, I.; Kovacs, Z.

2000-01-01

The MGC-20E (NIIEFA, Leningrad, USSR) variable energy compact cyclotron (k=20) was installed in ATOMKI (Debrecen, Hungary) in 1985. Protons, deuterons, 3 He- and α-particles can be accelerated with currents up to 300 μA for internal irradiation and up to 50 μA for external beams. The establishment of the Cyclotron Laboratory was partly supported by the International Atomic Energy Agency. The application of the cyclotron is multipurpose: basic nuclear research, application of activation technique for analytical and wear studies, application of intense fast neutron source for agro-biological, bio-medical application and for radiation damage test of electronic components, and finally radioisotope production for medical diagnostics and for other scientific and applied fields. The cyclotron laboratory has six target rooms, a radiochemistry laboratory and a medical unit equipped with PET

Method and apparatuses for ion cyclotron spectrometry

Science.gov (United States)

Dahl, David A [Idaho Falls, ID; Scott, Jill R [Idaho Falls, ID; McJunkin, Timothy R [Idaho Falls, ID

2012-03-06

An ion cyclotron spectrometer may include a vacuum chamber that extends at least along a z-axis and means for producing a magnetic field within the vacuum chamber so that a magnetic field vector is generally parallel to the z-axis. The ion cyclotron spectrometer may also include means for producing a trapping electric field within the vacuum chamber. The trapping electric field may comprise a field potential that, when taken in cross-section along the z-axis, includes at least one section that is concave down and at least one section that is concave up so that ions traversing the field potential experience a net magnetron effect on a cyclotron frequency of the ions that is substantially equal to zero. Other apparatuses and a method for performing ion cyclotron spectrometry are also disclosed herein.

Direct production of ^99mTc using a small medical cyclotron

Energy Technology Data Exchange (ETDEWEB)

Lapi, Suzanne [Washington Univ., St. Louis, MO (United States)

2017-10-03

This project describes an investigation towards the production of ^99mTc with a small medical cyclotron. This endeavor addresses the current urgent problem of availability of ^99mTc due to the ongoing production reactor failures and the upcoming Canadian reactor shut down. Currently, ^99mTc is produced via nuclear fission using highly enriched uranium which is a concern due to nuclear proliferation risks. In addition to this, the United States is dependent solely on currently unreliable foreign sources of this important medical isotope. Clearly, a need exists to probe alternative production routes of ^99mTc. In the first year, this project measured cross-sections and production yields of potential pathways to ^99mTc and associated radionuclidic impurities produced via these pathways using a small 15 MeV medical cyclotron. During the second and third years target systems for the production of ^99mTc via the most promising reaction routes were developed and separation techniques for the isolation of ^99mTc from the irradiated target material will be investigated. Systems for the recycling of the enriched target isotopes as well as automated target processing systems were examined in years four and five. This project has the potential to alleviate some of the current crisis in the medical community by developing a technique to produce ^99mTc on location at a university hospital. This technology will be applicable at many other sites in the United States as many other similar, low energy (<20 MeV) cyclotrons (currently used for a few hours per day for the production of [¹⁸F]fluorodeoxyglucose) are available for production of ^99mTc though this method, thus leading to job creation and preservation.

Radionuclide concentrations in soils and produce from Cochiti, Jemez, Taos, and San Ildefonso Pueblo Gardens

International Nuclear Information System (INIS)

Fresquez, P.R.; Armstrong, D.R.; Salazar, J.G.

1995-05-01

Radionuclide ( 3 H, 90 Sr, 137 Cs, 238 Pu, 239 Pu, and total uranium) concentrations were determined in soils and produce collected from Cochiti, Jemez, Taos, and San Ildefonso Pueblo gardens. All radionuclides in soils from Pueblo areas were within or just above regional statistical (natural and/or worldwide fallout) reference levels. Similarily, the average levels of radionuclides in produce collected from Cochiti, Jemez, Taos, and San Ildefonso Pueblo gardens were not significantly different in produce collected from regional (background) locations. The effective (radiation) dose equivalent from consuming 352 lb of produce from Cochiti, Jemez, Taos, and San Ildefonso, after natural background has been subtracted, was 0.036 (±0.016), 0.072 (±0.051), 0.012 (±0.027), and 0.110 (±0.102) mrem/yr, respectively. The highest calculated dose, based on the mean + 2 std dev (95% confidence level), was 0.314 mrem/yr; this was <0.4% of the International Commission on Radiological Protection permissible dose limit for protecting members of the public

In-house cyclotron production of high-purity Tc-99m and Tc-99m radiopharmaceuticals.

Science.gov (United States)

Martini, Petra; Boschi, Alessandra; Cicoria, Gianfranco; Zagni, Federico; Corazza, Andrea; Uccelli, Licia; Pasquali, Micòl; Pupillo, Gaia; Marengo, Mario; Loriggiola, Massimo; Skliarova, Hanna; Mou, Liliana; Cisternino, Sara; Carturan, Sara; Melendez-Alafort, Laura; Uzunov, Nikolay M; Bello, Michele; Alvarez, Carlos Rossi; Esposito, Juan; Duatti, Adriano

2018-05-30

In the last years, the technology for producing the important medical radionuclide technetium-99m by cyclotrons has become sufficiently mature to justify its introduction as an alternative source of the starting precursor [ 99m Tc][TcO 4 ] - ubiquitously employed for the production of 99m Tc-radiopharmaceuticals in hospitals. These technologies make use almost exclusively of the nuclear reaction 100 Mo(p,2n) 99m Tc that allows direct production of Tc-99m. In this study, it is conjectured that this alternative production route will not replace the current supply chain based on the distribution of 99 Mo/ 99m Tc generators, but could become a convenient emergency source of Tc-99m only for in-house hospitals equipped with a conventional, low-energy, medical cyclotron. On this ground, an outline of the essential steps that should be implemented for setting up a hospital radiopharmacy aimed at the occasional production of Tc-99m by a small cyclotron is discussed. These include (1) target production, (2) irradiation conditions, (3) separation/purification procedures, (4) terminal sterilization, (5) quality control, and (6) Mo-100 recovery. To address these issues, a comprehensive technology for cyclotron-production of Tc-99m, developed at the Legnaro National Laboratories of the Italian National Institute of Nuclear Physics (LNL-INFN), will be used as a reference example. Copyright © 2018 Elsevier Ltd. All rights reserved.

Radionuclides in produced water from Norwegian oil and gas installations - concentrations and bioavailability

International Nuclear Information System (INIS)

Eriksen, D.Oe.; Sidhu, R.; Stralberg, E.; Iden, K.I.; Hylland, K.; Ruus, A.; Roeyset, O.; Berntssen, M.H.G.; Rye, H.

2006-01-01

Substantial amounts of produced water, containing elevated levels of radionuclides (mainly 226 Ra and 228 Ra) are discharged to the sea as a result of oil and gas production on the Norwegian Continental Shelf. So far no study has assessed the potential radiological effects on marine biota in connection with radionuclide discharges to the North Sea. The main objective of the project is to establish radiological safe discharge limits for radium, lead and polonium associated with other components in produced water from oil and gas installations on the Norwegian continental shelf. This study reports results indicating that the presence of added chemicals such as scale inhibitors in produced water has a marked influence on the formation of radium and barium sulphates when produced water is mixed with sea water. Thus, the mobility and bioavailability of radium (and barium) will be larger than anticipated. Also, the bioavailability of food-borne radium is shown to increase due to presence of such chemicals. (author)

Radiation safety and operational health physics of hospital based medical cyclotrons

International Nuclear Information System (INIS)

Mukherjee, B.

2002-01-01

Full text: Compact, low energy, high current Medical Cyclotrons are now primarily used to produce large activities of short lived, neutron deficient, positron- emitting radioisotopes. These isotopes constitute the key ingredients of important PET (Positron Emission Tomography) radiopharmaceuticals used in diagnostic nuclear medicine. The PET-radioisotope producing Medical Cyclotrons are now increasingly installed in modern urban hospitals in many countries of the world. Modern Medical Cyclotrons run at a very high beam current (∼100-200 micro Amp) level and thereby produce intense fields of parasitic gamma rays and neutrons, causing the activation of cyclotron components, ambient air and radiation exposure to patients and members of the public. This report highlights the important operational aspects and the characteristics of the radiation fields produced by Medical Cyclotrons. The pathways of personnel radiation exposure are also analyzed. The above information constitutes the scientific basis of a sound operational health physics service, which is manifested in an effective dose reduction and an enhanced radiological safety of the Medical Cyclotron facility within the framework of ALARA

Review of research on impacts to biota of discharges of naturally occurring radionuclides in produced water to the marine environment

International Nuclear Information System (INIS)

Hosseini, Ali; Brown, Justin E.; Gwynn, Justin P.; Dowdall, Mark

2012-01-01

Produced water has been described as the largest volume waste stream in the exploration and production process of oil and gas. It is accompanied by discharges of naturally occurring radionuclides raising concerns over the potential radiological impacts of produced water on marine biota. In the Northern European marine environment, radioactivity in produced water has received substantial attention owing to the OSPAR Radioactive Substances Strategy which aims at achieving ‘concentrations in the environment near background values for naturally occurring radioactive substances’. This review provides an overview of published research on the impacts to biota from naturally occurring radionuclides discharged in produced water by the offshore oil and gas industry. In addition to summarising studies and data that deal directly with the issue of dose and effect, the review also considers studies related to the impact of added chemicals on the fate of discharged radionuclides. The review clearly illustrates that only a limited number of studies have investigated possible impacts on biota from naturally occurring radionuclides present in produced water. Hence, although these studies indicate that the risk to the environment from naturally occurring radionuclides discharged in produced water is negligible, the substantial uncertainties involved in the assessments of impact make it difficult to be conclusive. With regard to the complexity involved in the problem under consideration there is a pressing need to supplement existing data and acquire new knowledge. Finally, the present work identifies some knowledge gaps to indicate future research requirements. -- Highlights: ► Produced water from offshore oil industry contains naturally occurring radionuclides. ► Published research on the impacts to biota from these radionuclides is reviewed. ► Review includes impact of added chemicals on the fate of discharged radionuclides. ► Studies indicate negligible risk to biota

Evolution of PET and SPECT tracers from cyclotrons: production and application

International Nuclear Information System (INIS)

Stoecklin, G.

1992-01-01

Small cyclotrons play an increasing role in the production of medically useful isotopes. Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) are major tools in modern nuclear medicine for monitoring regional physiological and pharmacological functions at a molecular level. This requires physiological substrates or drugs labeled with suitable positron emitters or single photon emitters. Short-lived neutron deficient radioisotopes of high specific activity and high radionuclidic purity are needed. Some examples of radionuclide production, the development of radiopharmaceuticals for PET and SPECT, and their applications is presented with special emphasis on fluorine-18 and iodine-123. (author)

Ion-Beam-Excited Electrostatic Ion Cyclotron Waves

DEFF Research Database (Denmark)

Michelsen, Poul; Pécseli, Hans; Juul Rasmussen, Jens

1976-01-01

Self-excited electrostatic ion cyclotron waves were observed in an ion-beam-plasma system produced in a DP-operated Q-machine. The frequency of the waves showed the theoretically predicted variation with the magnetic field.......Self-excited electrostatic ion cyclotron waves were observed in an ion-beam-plasma system produced in a DP-operated Q-machine. The frequency of the waves showed the theoretically predicted variation with the magnetic field....

Report on the 1st research co-ordination meeting of the co-ordinated research project on standardized high current solid targets for cyclotron production of diagnostic and therapeutic radionuclides

International Nuclear Information System (INIS)

2000-01-01

Radioisotopes produced with a cyclotron and their corresponding radiopharmaceuticals have already been shown to be extremely valuable in basic medical research, disease diagnosis and radiotherapy treatment. There are more than 200 cyclotron facilities worldwide and the number is growing every year. A number of the Member States have acquired cyclotrons for the purpose of producing radioisotopes for nuclear medicine and a number of others have expressed an interest in acquiring such facilities. This report is concerned with the production of four radiotracers: Iodine-123, Iodine-124, Thallium-201 and Palladium-103. Iodine-123 is already widely used in SPECT studies, I-124 has shown great promise and can be used for PET studies as well as in radiotherapy. Tl-201 is widely used throughout the world as 201 Tl + for measuring cardiac blood flow. It is a routine tool that is needed for the Nuclear Medicine communities and can be made available by those countries possessing a cyclotron facility with 30 MeV protons. Moreover, as preliminary results dealing with the labelling of chelated polypeptides with trivalent cationic Tl-201 are very promising; the nuclide can also be tried as a potential substitute for Indium tracers in SPECT diagnosis involving polypeptides. Palladium-103, an Auger electron emitter, has become an extremely important radionuclide for therapy. The Co-ordinated Research Programme (CRP) focuses on the optimisation and standardisation of solid phase cyclotron target technology for the production of I-123, I-124, Tl-201 and Pd-103. In particular, as originally proposed and further discussed and agreed upon during the 1st Research Co-ordination Meeting, the main technical goals of the CRP are described as follows: (i) to investigate the possibility of using electrodeposited tellurium and melted tellurium oxide as target material for the production of I-123 and I-124. For the oxide target, the following parameters and techniques will be explored: 1) methods

Iodine-123 (123I) is promising radiopharmaceutical in the radionuclide diagnostics

International Nuclear Information System (INIS)

Tazhedinov, I.T.

2003-01-01

In the paper some advantages of the radiopharmaceuticals with 123 I against 99m Tc preparations are shown. It is noted that the 123 I is the most favourable among cyclotron radionuclides for radionuclide diagnostics by it nuclear-physical characteristics. With application of 123 I it is possible to attain a significant progress in the thyroid examination. 123 I labelled preparations should have a high bond strength providing the high information valuation of examinations

Developing the smallest possible medical cyclotron

CERN Multimedia

Katarina Anthony

2011-01-01

Imagine a portable medical cyclotron operated in a conventional radioactive facility at a hospital. Imagine a nurse or technician switching it on and producing isotopes at the patient’s bedside. Sounds like science fiction? Think again.   CERN has teamed up with Spain’s national scientific research centre (CIEMAT) to develop an avant-garde cyclotron to be used for Positron Emission Tomography (PET). “We plan to make a cyclotron that doesn't need an insulated building or ‘vault’: a cyclotron small enough to fit inside a hospital lift,” explains Jose Manuel Perez, who is leading the CIEMAT/CERN collaboration. “It will be the smallest possible medical cyclotron for single patient dose production and will dramatically reduce costs for hospitals.” While PET technology has transformed imaging techniques, many of its medical benefits have remained confined to highly specialised hospitals. “Studies have foun...

Preparation of cyclotron-produced {sup 186}Re and comparison with reactor-produced {sup 186}Re and generator-produced {sup 188}Re for the labeling of bombesin

Energy Technology Data Exchange (ETDEWEB)

Moustapha, Moustapha E. [Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211 (United States); University of Missouri Research Reactor (MURR), University of Missouri-Columbia, Columbia, MO 65211 (United States); Ehrhardt, Gary J. [Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211 (United States); University of Missouri Research Reactor (MURR), University of Missouri-Columbia, Columbia, MO 65211 (United States); Smith, Charles J. [Department of Radiology, University of Missouri-Columbia, Columbia, MO 65211 (United States); University of Missouri Research Reactor (MURR), University of Missouri-Columbia, Columbia, MO 65211 (United States); Research Services, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO 65201 (United States); Szajek, Lawrence P. [Positron Emission Tomography Department, National Institutes of Health, Bethesda, MD 20892-1180 (United States); Eckelman, William C. [Positron Emission Tomography Department, National Institutes of Health, Bethesda, MD 20892-1180 (United States); Jurisson, Silvia S. [Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211 (United States)]. E-mail: jurissons@missouri.edu

2006-01-15

The radioisotopes {sup 186}Re and {sup 188}Re have been extensively investigated for various forms of radiotherapy due to their useful and high-abundance {beta} particle emissions, low-abundance and imageable {gamma}-rays, and chemical resemblance to technetium. In addition, {sup 188}Re is available in no-carrier-added (NCA) form from long lived W-188 generators, whereas {sup 186}Re can be produced in large quantities from reactors, although not in NCA form. However, NCA {sup 186}Re can be produced on a cyclotron by a (p,n) reaction on {sup 186}W. The purpose of this study was to compare labeling of the peptide bombesin with these three forms of rhenium radioisotopes. Cyclotron-produced NCA {sup 186}Re was separated radiochemically from enriched {sup 186}W (96.9%) targets using high-purity methyl ethyl ketone (MEK). The resulting {sup 186}Re-MEK was then loaded onto a small alumina column to separate the resulting NCA {sup 186}Re from any remaining {sup 186}W. The experimental levels of impurities associated with {sup 186}Re at the end of the separation process were found to be 5.7x10{sup -6} Ci of {sup 182}Re (0.57%, t {sub 1/2}=12.7 h) and 1.283x10{sup -5} Ci of {sup 182m}Re (1.28%, t {sub 1/2}=2.67 days). The radionuclidic purity of the separated {sup 186}Re was found to be 99.6%, whereas the chemical identity was determined by reversed phase high-performance liquid chromatography (RP-HPLC) to be perrhenate ({sup 186}ReO{sub 4} {sup -}). Generator-produced {sup 188}ReO{sub 4} {sup -} from a {sup 188}W/{sup 188}Re generator (Oak Ridge National Laboratory) and CA {sup 186}ReO{sub 4} {sup -} produced from a {sup 185}Re(n,{gamma}){sup 186}Re reaction at the University of Missouri Research Reactor (MURR) were used for comparison with the NCA {sup 186}Re in subsequent studies. N{sub 3}S-5-Ava-BBN(7-14)NH{sub 2} conjugates provide flexibility for designing {sup 186,188}Re-labeled conjugates that retain high in vitro and in vivo specificity targeting of GRP receptor

Distribution of Hanford reactor produced radionuclides in the marine environment, 1961-73

International Nuclear Information System (INIS)

Seymour, A.H.

1980-01-01

At Hanford (U.S.A.), the plutonium-producing reactors were in operation during 1944-1971. The period of maximum reactor operation was 1955-1965, when eight reactors were in operation. The reactor deactivation programme began in 1965 and the last reactor was deactivated in 1971. All these reactors were cooled by Columbia River water which passed through the reactors and then was discharged to the river and ultimately to the North Pacific. The Laboratory of Radiation Ecology (LRE) of the University of Washington started an environmental survey programme in 1965 and continued it upto 1973 i.e. even after the last plutonium producing reactor was deactivated. The programme objectives were: (1) to find the geographical distribution and concentration of Hanford produced radionuclides in water, sediments and biota of the marine environment, (2) to relate the operation of the Hanford reactors during the period of deactivation to the concentration of radionuclides in marine organisms, and (3) to observe the rate at which the marine organisms cleansed themselves of 65 Zn after the primary source had been removed. An account of the programme and highlights of the observations are reported. Most of the radioactivity entering the river water and marine organisms was due to 51 Cr, 65 Zn and 32 P of which 65 Zn was found to be the most abundant radionuclide in the biological samples. The rate of radioactivity from the river water entering into the Ocean was about 1000 curies per day and it did not produce any observable effects on populations of marine organisms. The internal dose to man from 65 Zn via seafoods was only a small fraction of the permissible dose for individual members of the population. (M.G.B.)

Low energy cyclotron for radiocarbon dating

International Nuclear Information System (INIS)

Welch, J.J.

1984-12-01

The measurement of naturally occurring radioisotopes whose half lives are less than a few hundred million years but more than a few years provides information about the temporal behavior of geologic and climatic processes, the temporal history of meteoritic bodies as well as the production mechanisms of these radioisotopes. A new extremely sensitive technique for measuring these radioisotopes at tandem Van de Graaff and cyclotron facilities has been very successful though the high cost and limited availability have been discouraging. We have built and tested a low energy cyclotron for radiocarbon dating similar in size to a conventional mass spectrometer. These tests clearly show that with the addition of a conventional ion source, the low energy cyclotron can perform the extremely high sensitivity 14 C measurements that are now done at accelerator facilities. We found that no significant background is present when the cyclotron is tuned to accelerate 14 C negative ions and the transmission efficiency is adequate to perform radiocarbon dating on milligram samples of carbon. The internal ion source used did not produce sufficient current to detect 14 C directly at modern concentrations. We show how a conventional carbon negative ion source, located outside the cyclotron magnet, would produce sufficient beam and provide for quick sampling to make radiocarbon dating milligram samples with a modest laboratory instrument feasible

Preparation of Radiopharmaceuticals Labeled with Metal Radionuclides

Energy Technology Data Exchange (ETDEWEB)

Welch, M.J.

2012-02-16

The overall goal of this project was to develop methods for the production of metal-based radionuclides, to develop metal-based radiopharmaceuticals and in a limited number of cases, to translate these agents to the clinical situation. Initial work concentrated on the application of the radionuclides of Cu, Cu-60, Cu-61 and Cu-64, as well as application of Ga-68 radiopharmaceuticals. Initially Cu-64 was produced at the Missouri University Research Reactor and experiments carried out at Washington University. A limited number of studies were carried out utilizing Cu-62, a generator produced radionuclide produced by Mallinckrodt Inc. (now Covidien). In these studies, copper-62-labeled pyruvaldehyde Bis(N{sup 4}-methylthiosemicarbazonato)-copper(II) was studied as an agent for cerebral myocardial perfusion. A remote system for the production of this radiopharmaceutical was developed and a limited number of patient studies carried out with this agent. Various other copper radiopharmaceuticals were investigated, these included copper labeled blood imaging agents as well as Cu-64 labeled antibodies. Cu-64 labeled antibodies targeting colon cancer were translated to the human situation. Cu-64 was also used to label peptides (Cu-64 octriatide) and this is one of the first applications of a peptide radiolabeled with a positron emitting metal radionuclide. Investigations were then pursued on the preparation of the copper radionuclides on a small biomedical cyclotron. A system for the production of high specific activity Cu-64 was developed and initially the Cu-64 was utilized to study the hypoxic imaging agent Cu-64 ATSM. Utilizing the same target system, other positron emitting metal radionuclides were produced, these were Y-86 and Ga-66. Radiopharmaceuticals were labeled utilizing both of these radionuclides. Many studies were carried out in animal models on the uptake of Cu-ATSM in hypoxic tissue. The hypothesis is that Cu-ATSM retention in vivo is dependent upon the

Radionuclides in produced water from Norwegian oil and gas installations — Concentrations and bioavailability

Science.gov (United States)

Eriksen, D. Ø.; Sidhu, R.; Strålberg, E.; Iden, K. I.; Hylland, K.; Ruus, A.; Røyset, O.; Berntssen, M. H. G.; Rye, H.

2006-01-01

Substantial amounts of produced water, containing elevated levels of radionuclides (mainly 226Ra and 228Ra) are discharged to the sea as a result of oil and gas production on the Norwegian Continental Shelf. So far no study has assessed the potential radiological effects on marine biota in connection with radionuclide discharges to the North Sea. The main objective of the project is to establish radiological safe discharge limits for radium, lead and polonium associated with other components in produced water from oil and gas installations on the Norwegian continental shelf. This study reports results indicating that the presence of added chemicals such as scale inhibitors in produced water has a marked influence on the formation of radium and barium sulphates when produced water is mixed with sea water. Thus, the mobility and bioavailability of radium (and barium) will be larger than anticipated. Also, the bioavailability of food-borne radium is shown to increase due to presence of such chemicals.

H-superconducting cyclotron for PET isotope production

International Nuclear Information System (INIS)

Smirnov, V.L.; Vorozhtsov, S.B.; Vincent, J.

2014-01-01

The scientific design of a 14-MeV H - compact superconducting cyclotron for producing of the 18 F and 13 N isotopes has been developed. Main requirements to the facility as a medical accelerator are met in the design. In particular, the main requirement for the cyclotron was the smallest possible size due to the superconducting magnet. The calculations show that the proposed cyclotron allows extracted beam intensity over 500 μA. To increase system reliability and production rates, an external H - ion source is applied. The choice of the cyclotron concept, design of the structure elements, calculation of the electromagnetic fields and beam dynamics from the ion source to the extraction system were performed.

A new internal target system for production of 211At on the cyclotron U-120M

Czech Academy of Sciences Publication Activity Database

Lebeda, Ondřej; Jiran, Rudolf; Ráliš, Jan; Štursa, Jan

2005-01-01

Roč. 63, - (2005), s. 49-53 ISSN 0969-8043 R&D Projects: GA AV ČR KJB4048302 Institutional research plan: CEZ:AV0Z10480505 Keywords : radionuclides production * 211At * cyclotron Subject RIV: CH - Nuclear ; Quantum Chemistry Impact factor: 0.757, year: 2005

Review of Cyclotrons for the Production of Radioactive Isotopes for Medical and Industrial Applications

Science.gov (United States)

Schmor, Paul

2011-02-01

Radioactive isotopes are used in a wide range of medical, biological, environmental and industrial applications. Cyclotrons are the primary tool for producing the shorter-lived, proton-rich radioisotopes currently used in a variety of medical applications. Although the primary use of the cyclotron-produced short-lived radioisotopes is in PET/CT (positron emission tomography/computed tomography) and SPECT (single photon emission computed tomography) diagnostic medical procedures, cyclotrons are also producing longer-lived isotopes for therapeutic procedures as well as for other industrial and applied science applications. Commercial suppliers of cyclotrons are responding by providing a range of cyclotrons in the energy range of 3-70MeV for the differing needs of the various applications. These cyclotrons generally have multiple beams servicing multiple targets. This review article presents some of the applications of the radioisotopes and provides a comparison of some of the capabilities of the various current cyclotrons. The use of nuclear medicine and the number of cyclotrons supplying the needed isotopes are increasing. It is expected that there will soon be a new generation of small "tabletop" cyclotrons providing patient doses on demand.

Initial operation of the cyclotron CYTRACK

International Nuclear Information System (INIS)

Denisov, Yu.N.; Dolya, S.N.; Kalinichenko, V.V.; Karamysheva, G.A.; Kostromin, S.A.; Fedorenko, S.B.

2005-01-01

The industrial cyclotron CYTRACK is dedicated to produce the track membranes. It is the basic instrument for the industry of membrane products to be consumed in medicine, biotechnology, pharmacology, microelectronics and many other industries. Cyclotron CYTRACK started working in August 2002. Argon ions were accelerated to the project energy - 2.4 MeV/nucleon, the extracted beam intensity was about 200 nA, the extraction efficiency totaled ∼50%

Cyclotron to Oslo University

International Nuclear Information System (INIS)

Sandstad, J.

1978-01-01

The new cyclotron was delivered to Oslo University on September 21st 1978, and was mannfactured by A/B Scandtronix of Uppsala, Sweden. The contract price was 6,8 million Norwegian kroner and installation will cost a further 4 million. The main specifications are given. The energy will be 36 MeV for protons and alpha particles, 18 MeV deuterons and 48 MeV for helium 3. The principle of a cyclotron is briefly described. While the primary purpose of the machine is nuclear research it is also planned to produce short-lived radioisotopes, primarily iodine 123. (JIW)

Use of maze in cyclotron hoppers

International Nuclear Information System (INIS)

Fernandes, Fernando A.; Alves, Juliano S.; Fochesatto, Cintia; Cerioli, Luciane; Borges, Joao Alfredo; Gonzalez, Delfin; Silva, Daniel C.

2013-01-01

Introduction: the increasing number of cyclotrons in Brazil due to constitutional amendment 49 /06 that enabled the production of radiopharmaceuticals with a short half - life by private companies. The radionuclides used for PET - CT require production centers near or within the diagnostic centers. In order to minimize maintenance and operating risks, gaining efficiency, our facility was the first in Brazil to use the access to a cyclotron bunker via maze, rather than armored door stopper type. Materials: the design calculations were based on the Monte Carlo method (MCNP5 - Monte Carlo N-Particletransportcode version 5). At the ends of the labyrinth are installed a door of polyethylene, for thermalization of neutrons, and other of wood for limiting access. Both legs of the maze have wall thickness of 100cm. In inspection Brazilian CNEN realize measures of dose rate for neutrons and gamma 9 points: 7 around the bunker, 1 over the bunker and 1 in the exhaust with the cyclotron operating with maximum load, double beam of 50uA for 2 hours. After commissioning were carried out around the bunker, the following measures: cumulative dose in three months with dosimeters for neutron rate dose with a gas proportional detector type filled with 3 He and polyethylene neutron moderator and dose rate with a Geiger - Mueller detector for gamma radiation. Readings with neutron detectors were classified as background radiation and dose rates were always below the limits established in standard EN 3.01, and the calculation of the predicted regardless of the intensity of irradiation inside the bunker. Conclusion: the use of labyrinths as a way to access the bunkers cyclotron has been shown to be effective as the radiation shielding and efficient by allowing quick and easy access, virtually eliminating the maintenance

Evaluation of the production capabilities of 18F, 11C, 13N and 15O PET isotopes at the PET-cyclotron-radiochemistry site of Messina University

OpenAIRE

Auditore, Lucrezia; Amato, Ernesto; Italiano, Antonio; Pagano, Benedetta; Baldari, Sergio

2017-01-01

The production of 18F, 11C, 13N, and 15O positron emitting radionuclides for PET imaging is usually accomplished in Nuclear Medicine Departments through direct nuclear reactions induced by protons accelerated by compact medical cyclotrons on liquid or gaseous targets. Messina University has funded the construction of a PET-cyclotron-radio-chemistry plant at the Messina University Hospital, equipped with a 11 MeV self-shielded cyclotron. We estimated the expected production yields of these nuc...

Radiation shielding and health physics instrumentation for PET medical cyclotrons

International Nuclear Information System (INIS)

Mukherjee, B.

2002-01-01

Full text: Modern Medical Cyclotrons produce a variety of short-lived positron emitting PET radioisotopes, and as a result are the source of intense neutron and gamma radiations. Since such cyclotrons are housed within hospitals or medical clinics, there is significant potential for un-intentional exposure to staff or patients in proximity to cyclotron facilities. Consequently, the radiological hazards associated with Cyclotrons provide the impetus for an effective radiological shielding and continuous monitoring of various radiation levels in the cyclotron environment. Management of radiological hazards is of paramount importance for the safe operation of a Medical Cyclotron facility. This work summarised the methods of shielding calculations for a compact hospital based Medical Cyclotron currently operating in Canada, USA and Australia. The design principle and operational history of a real-time health physics monitoring system (Watchdog) operating at a large multi-energy Medical Cyclotron is also highlighted

Diagnostic system for the nuclear medicine with baby cyclotron

International Nuclear Information System (INIS)

Kashihara, Masao; Wakasa, Shyuichiro

1982-01-01

The system of cyclotron nuclear medicine consists of ''RI-production by using the cyclotron'', ''production of radio-pharmaceuticals labeled with RI'', ''positron tomography''. On the other hand, Ultra compact cyclotron (Baby cyclotron) itself, RI production technique and positron tomography have been rapidly developed and advanced. We think that these three functions must be balance in the development in order to spread this system into the routine work in the hospital. However, since the technology of the synthesis for the labeled compounds is not so developed so far, more advance can be strongly expected. In this report, construction of the cyclotron nuclear medicine, utility for the practical use of RI produced by using the cyclotron, technique of RI production, and the studies on automated and efficient productions of radio-pharmaceuticals labeled with short-lived positron emitters for medical diagnostic use are described. (author)

Building 211 cyclotron characterization survey report

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-03-30

The Building 211 Cyclotron Characterization Survey includes an assessment of the radioactive and chemical inventory of materials stored within the facility; an evaluation of the relative distribution of accelerator-produced activation products within various cyclotron components and adjacent structures; measurement of the radiation fields throughout the facility; measurement and assessment of internal and external radioactive surface contamination on various equipment, facility structures, and air-handling systems; and an assessment of lead (Pb) paint and asbestos hazards within the facility.

Cyclotron produced Tc-99m: testing compatibility with established kits

Czech Academy of Sciences Publication Activity Database

Lebeda, Ondřej; Ráliš, Jan; Hradilek, Pavel; Hanč, Petr; van Lier, E. J.; Zyuzin, A.; Moša, M.

2013-01-01

Roč. 40, 2 Supplement (2013), S424-S425 ISSN 1619-7070. [Annual Congress of the European Association of Nuclear Medicine (EANM). 19.10.2013-23.10.2013, Lyon] Institutional support: RVO:61389005 Keywords : cyclotron U-120M * Tc-99m * 100Mo Subject RIV: BG - Nuclear, Atomic and Molecular Physics , Colliders

Dynamic effects on cyclotron scattering in pulsar accretion columns

International Nuclear Information System (INIS)

Brainerd, J.J.; Meszaros, P.

1991-01-01

A resonant scattering model for photon reprocessing in a pulsar accretion column is presented. The accretion column is optically thin to Thomson scattering and optically thick to resonant scattering at the cyclotron frequency. Radiation from the neutron star surface propagates freely through the column until the photon energy equals the local cyclotron frequency, at which point the radiation is scattered, much of it back toward the star. The radiation pressure in this regime is insufficient to stop the infall. Some of the scattered radiation heats the stellar surface around the base of the column, which adds a softer component to the spectrum. The partial blocking by the accretion column of X-rays from the surface produces a fan beam emission pattern. X-rays above the surface cyclotron frequency freely escape and are characterized by a pencil beam. Gravitational light bending produces a pencil beam pattern of column-scattered radiation in the antipodal direction, resulting in a strongly angle-dependent cyclotron feature. 31 refs

Preparation of Radiopharmaceuticals Labeled with Metal Radionuclides. Final Report

International Nuclear Information System (INIS)

Welch, M.J.

2012-01-01

The overall goal of this project was to develop methods for the production of metal-based radionuclides, to develop metal-based radiopharmaceuticals and in a limited number of cases, to translate these agents to the clinical situation. Initial work concentrated on the application of the radionuclides of Cu, Cu-60, Cu-61 and Cu-64, as well as application of Ga-68 radiopharmaceuticals. Initially Cu-64 was produced at the Missouri University Research Reactor and experiments carried out at Washington University. A limited number of studies were carried out utilizing Cu-62, a generator produced radionuclide produced by Mallinckrodt Inc. (now Covidien). In these studies, copper-62-labeled pyruvaldehyde Bis(N 4 -methylthiosemicarbazonato)-copper(II) was studied as an agent for cerebral myocardial perfusion. A remote system for the production of this radiopharmaceutical was developed and a limited number of patient studies carried out with this agent. Various other copper radiopharmaceuticals were investigated, these included copper labeled blood imaging agents as well as Cu-64 labeled antibodies. Cu-64 labeled antibodies targeting colon cancer were translated to the human situation. Cu-64 was also used to label peptides (Cu-64 octriatide) and this is one of the first applications of a peptide radiolabeled with a positron emitting metal radionuclide. Investigations were then pursued on the preparation of the copper radionuclides on a small biomedical cyclotron. A system for the production of high specific activity Cu-64 was developed and initially the Cu-64 was utilized to study the hypoxic imaging agent Cu-64 ATSM. Utilizing the same target system, other positron emitting metal radionuclides were produced, these were Y-86 and Ga-66. Radiopharmaceuticals were labeled utilizing both of these radionuclides. Many studies were carried out in animal models on the uptake of Cu-ATSM in hypoxic tissue. The hypothesis is that Cu-ATSM retention in vivo is dependent upon the oxygen

Risk assessment of 30 MeV cyclotron facilities

Energy Technology Data Exchange (ETDEWEB)

Jeong, Gyo Seong; Lee, Jin Woo [Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup (Korea, Republic of); Kim, Chong Yeal [Dept. of Radiation Science and Technology, Chonbuk National University, Jeonju (Korea, Republic of)

2017-03-15

A cyclotron is a kind of particle accelerator that produces a beam of charged particles for the production of medical, industrial, and research radioisotopes. More than 30 cyclotrons are operated in Korea to produce 18F, an FDG synthesis at hospitals. A 30-MeV cyclotron was installed at ARTI (Advanced Radiation Technology Institute, KAERI) mainly for research regarding isotope production. In this study, we analyze and estimate the items of risk such as the problems in the main components of the cyclotron, the loss of radioactive materials, the leakage of coolant, and the malfunction of utilities, fres and earthquakes. To estimate the occurrence frequency in an accident risk assessment, five levels, i.e., Almost certain, Likely, Possible, Unlikely, and Rare, are applied. The accident consequence level is classified under four grades based on the annual permissible dose for radiation workers and the public in the nuclear safety law. The analysis of the accident effect is focused on the radioactive contamination caused by radioisotope leakage and radioactive material leakage of a ventilation filter due to a free. To analyze the risks, Occupation Safety and Health Acts is applied. In addition, action plans against an accident were prepared after a deep discussion among relevant researchers. In this acts, we will search for hazard and introduce the risk assessment for the research 30-MeV cyclotron facilities of ARTI.

Risk assessment of 30 MeV cyclotron facilities

International Nuclear Information System (INIS)

Jeong, Gyo Seong; Lee, Jin Woo; Kim, Chong Yeal

2017-01-01

A cyclotron is a kind of particle accelerator that produces a beam of charged particles for the production of medical, industrial, and research radioisotopes. More than 30 cyclotrons are operated in Korea to produce 18F, an FDG synthesis at hospitals. A 30-MeV cyclotron was installed at ARTI (Advanced Radiation Technology Institute, KAERI) mainly for research regarding isotope production. In this study, we analyze and estimate the items of risk such as the problems in the main components of the cyclotron, the loss of radioactive materials, the leakage of coolant, and the malfunction of utilities, fres and earthquakes. To estimate the occurrence frequency in an accident risk assessment, five levels, i.e., Almost certain, Likely, Possible, Unlikely, and Rare, are applied. The accident consequence level is classified under four grades based on the annual permissible dose for radiation workers and the public in the nuclear safety law. The analysis of the accident effect is focused on the radioactive contamination caused by radioisotope leakage and radioactive material leakage of a ventilation filter due to a free. To analyze the risks, Occupation Safety and Health Acts is applied. In addition, action plans against an accident were prepared after a deep discussion among relevant researchers. In this acts, we will search for hazard and introduce the risk assessment for the research 30-MeV cyclotron facilities of ARTI

CYGNE, Foundation for Cyclotron Applications in Medicine, Netherlands

Energy Technology Data Exchange (ETDEWEB)

van de Bosch, R L.P. [Technische Hogeschool Eindhoven (Netherlands). Afdeling Technische Natuurkunde; Smithuis, L O.M.J. [St. Lambertusziekenhuis, Helmond (Netherlands). Afd. Nucleaire Geneeskunde

1981-01-01

At the Technical University of Eindhoven (Netherlands) a Foundation named CYGNE is established with the purpose to further the use of the research cyclotrons present in the country for the production of short-living radioisotopes specifically on behalf of nuclear medicine. The cooperation with a hospital and its pharmacist are procured for the production of various radiopharmaceuticals. This is the first time such a facility is available in the Netherlands. The foundation has four working groups to do research on radionuclides for positron emission tomography, neutron therapy, trace element analysis, and routine production or new production methods.

Cyclotron production of high-purity 123I for medical applications via the 127I(p,5n)123Xe → 123I nuclear reaction

International Nuclear Information System (INIS)

Lagunas-Solar, M.C.

1985-01-01

The use of iodine-123 in nuclear medicine procedures is well documented in the scientific literature. Also, several methods for its production based on accelerator techniques have been described. Indirectly made 123 I via the 127 I(p,5n) 123 Xe → 123 I reaction produces 123 I of > 99.9% radionuclidic purity, with only 125 I ( 123 I production were developed at the University of California at Davis, where since 1974 the 76-in. isochronous cyclotron of the Crocker Nuclear Laboratory has been used for routine biweekly production of high-purity no-carrier-added 123 I

Supernova-produced radionuclides in deep-sea sediments measured with AMS

International Nuclear Information System (INIS)

Feige, J.

2014-01-01

This thesis is dedicated to computational micromagnetics, where several new numerical methods are In this work a set of long-lived radionuclides is measured to detect supernova-traces presumably deposited on Earth 2-3 Myr ago. Approximately 100 samples of four deep-sea sediment cores (Indian Ocean) were analyzed for 26 Al, 53Mn, and 60 Fe with accelerator mass spectrometry (AMS). Additionally, 10 Be was measured to confirm the existing paleomagnetic chronology of the sediments. A signal of extraterrestrial 60 Fe, which is not produced in-situ on Earth, was detected in a time period of 1.7-3.2 Myr in the sediments used for this work. 60 Fe/ 26 Al ratios were used to calculate limits on theoretical nucleosynthesis models. A supernova-signature of 26 Al is hidden behind a terrestrial background. The measured 26 Al/ 10 Be ratios indicate, that the major source of 26 Al detected in the sediments is of atmospheric origin. Because of the extraordinarily good depth profile for the deep-sea sediments from the measured 26 Al data, this radionuclide was used for dating. (author) [de

The PET / cyclotron facility at Putrajaya Hospital - an update

International Nuclear Information System (INIS)

Siti Najila Mohd Janib; Suzilawati Muhd Sarowi; Munira Shaikh Nasir; Zulkifli Mohamed Hashim

2006-01-01

Malaysia desire to have a cyclotron for nuclear medical use came into realisation recently with the establishment of a PET/Cyclotron Facility at Putrajaya Hospital. The testing and commissioning of the cyclotron, hot cells, QC equipment and PET/CT started on March 27, culminating in the first patient to be injected on May 10 2006. Three other patients were to be followed on May 15. The patients from both the Kuala Lumpur and Putrajaya Hospital were pre-selected by physicians from these hospitals. The 18 MeV cyclotron is capable of generating 16.4 MeV protons and 8.4 MeV deuterons. The cyclotron at Putrajaya has three targets (2 liquid and 1 gas) and is capable of producing 18 F-FDG and 18 F-DOPA. To complement this, the facility has 2 modules for FDG synthesis, 1 for F-DOPA and 1 for nucleophilic synthesis. The facility will be GMP compliant. For the first production for human use, the water-18 target was irradiated for 50 minutes at 20 mA to produce 1.3 Ci of F-18. At the end of synthesis, the activity of the FDG obtained was 600 mCi. The product was then injected to a 26-year-old female, with a suspected adenocarcinoma. (Author)

Superconducting cyclotrons

International Nuclear Information System (INIS)

Blosser, H.G.; Johnson, D.A.; Burleigh, R.J.

1976-01-01

Superconducting cyclotrons are particularly appropriate for acceleration of heavy ions. A review is given of design features of a superconducting cyclotron with energy 440 (Q 2 /A) MeV. A strong magnetic field (4.6 tesla average) leads to small physical size (extraction radius 65 cm) and low construction costs. Operating costs are also low. The design is based on established technology (from present cyclotrons and from large bubble chambers). Two laboratories (in Chalk River, Canada and in East Lansing, Michigan) are proceeding with construction of full-scale prototype components for such cyclotrons

PIXE analysis by baby cyclotron

International Nuclear Information System (INIS)

Yoshida, Hyogo; Tanaka, Teruaki; Ito, Takashi; Toda, Yohjiro; Wakasa, Hideichiro

1988-01-01

The Japan Steel Works, Ltd. has been supplying a very small sized cyclotron (Baby Cyclotron) to hospitals and research facilities. The cyclotron is designed to produce short-lived radioisotopes for medical use. In the present study, this cyclotron is modified so that it can serve for PIXE analysis. The PIXE (particle induced X-ray emission) technique has the following features: (1) Down to 1 ng of trace material in a sample (mg - μg) can be detected, (2) An analysis run is completed in one to ten minutes, permitting economical analysis for a large number of samples, (3) Several elements can be analyzed simultaneously, with an almost constant sensitivity for a variety of elements ranging from aluminum to heavy metals, (4) Analysis can be performed nondestructively without a chemical process, and (5) The use of microbeam can provide data on the distribution of elements with a resolution of several μm. Software for analysis is developed to allow the modified equipment to perform peak search, background fitting, and identification and determination of peaks. A study is now being conducted to examine the performance of the equipment for PIXE analysis of thin samples. Satisfactory results have been obtained. The analysis time, excluding the background correction, is 5-10 min. (Nogami, K.)

Study of alternative routes for the production of innovative radionuclides for medical applications

International Nuclear Information System (INIS)

Duchemin, Charlotte

2015-01-01

Nuclear medicine is a specialty that uses radioactive nuclei for therapy or diagnosis of diseases such as different types of cancer. These radionuclides are coupled to carrier molecules to target sick cells. Currently, only few isotopes are used in clinical practice. However, many others may be of medical interest due to their emitted radiation and/or their half-life that can be adapted to the carrier molecule transit time and to the pathology. The aim of this PhD thesis is to study the production of innovative radionuclides for therapy and diagnosis applications in collaboration with the GIP ARRONAX, which possesses a multi-particle high energy cyclotron. A fundamental physical parameter to access the production rate of a radionuclide is the production cross section. Experimental data were measured for a selection of radionuclides: photon emitter (Tc-99m) and positron emitter (Sc-44g) for diagnosis, as well as electron emitters (Re-186, Tb-155 and Sn-117m) and α particles emitters (Th-226, Ra-223 and Bi-213) for therapeutic applications. These acquired data are obtained using alternative production routes compared to the commonly used. Data related to the contaminants produced during the irradiations were also extracted. The experimental cross section values are compared with theoretical model predictions. The large set of data obtained contributes to the theoretical physicist studies allowing to constrain their models to improve and/or validate them. (author)

Cyclotron production, radiochemical separation and quality control of platinum radiotracers for toxicological studies

International Nuclear Information System (INIS)

Bonardi, M.; Birattari, C.; Groppi, F.; Arginelli, D.; Gini, L.; Gallorini, M.

1998-01-01

The increasing concentration of Pt, Pd and Rh in the environment is mainly due to the release of these elements from the catalytic converters of the motorvehicles. This situation makes it necessary to carry out metallotoxicological experiments on both cell cultures and laboratory animals, in order to assess their impact on living organisms after a Long Term and Low Level Exposure (LLE). Both nuclear reactions nat Ir(p,xn) and nat Os(α,xn) were investigated in the energy range up to 45 MeV for protons and 38 MeV for alpha-particles, in order to optimize the irradiation parameters for the production of 188,189,191 Pt. Several sets of thin- and thick-target excitation functions were determined experimentally by cyclotron irradiation at both Milano and Ispra cyclotrons. This paper reports the irradiation parameters studied and adopted and two radiochemical procedures for the separation of radio-Pt from an Os target, as well as from ruthenium, iridium and gold impurities. These procedures were used to obtain very high specific activity Pt radionuclides in No Carrier Added (NCA) form. Radionuclidic, radiochemical and chemical purity measurements were carried out by the use of several techniques like γ-spectrometry, ion-exchange radio-chromatography, atomic absorption spectrometry and neutron activation analysis. (author)

Radionuclide production for PET with a linear electrostatic accelerator

International Nuclear Information System (INIS)

Shefer, R.E.; Hughey, B.J.; Klinkowstein, R.E.; Welch, M.J.

1993-01-01

A new type of linear electrostatic accelerator for the production of short-lived radionuclides for PET has been developed at Science Research Laboratory. The tandem cascade accelerator (TCA) is a low energy (3.7 MeV) proton and deuteron accelerator which can generate the four short-lived PET radionuclides in the quantities required for clinical use. The compact size, low weight, low power consumption and reduced radiation shielding requirements of the TCA result in a significant reduction in capital and operating costs when compared with higher energy cyclotron-based systems. Radioisotope target for the production of O-15, F-18, N-13 and C-11 have been designed specifically for use with the low energy TCA beam. A simple to use PC-based computer control system allows fully automated system operation and advanced scheduling of isotope production. Operating experience with the TCA and its PET radionuclide targets is described

Production of radionuclides with generators

International Nuclear Information System (INIS)

Khujaev, S.; Egamediev, S.Kh.

2004-01-01

Full text: The radionuclide generator provides a convenient means for researchers and clinicians to obtain a source of radionuclides without dependence on nuclear facilities (nuclear reactor or cyclotron). It should be noted that radionuclide generator technique yields products of very high purity and it offers moreover the only possible way of obtaining very short-lived radionuclides for practical applications. Therefore at present radionuclide generators have found important uses in nuclear medicine. This talk reviews the development of preparation methods for radionuclide generators of current interest: 99 Mo- 99m Tc, 188 W- 188 Re and 68 Ge- 68 Ga. 99 Mo- 99m Tc generator. 99m Tc is presently the most widely used radionuclide in diagnostic nuclear medicine. The reason for such a preeminent position of 99m Tc in clinical uses is its extremely favorable nuclear properties with γ-energy of 140 keV and short half-life of 6 hours. Chromatographic generator of 99 Mo- 99m Tc based on aluminium oxide using as eluent of isotonic saline solution, containing nitrate-ions has been produced in INP AS RU. However, the main disadvantage of this generator is that the eluent-saline solution contains some amount of nitrate-ions. Nitrate-ions added to maximize and stabilize 99m Tc yields would interfere with the chemical reactions which involve Sn(II) reduction of the pertechnetate ion and which are used subsequently in the preparation of radiopharmaceuticals. Therefore we proposed the new method for preliminary treatment of aluminium oxide by the external gamma (Co-60) irradiation. It is found that the aluminium oxide has got electron-acceptor properties after gamma-irradiation. Adsorption of 99 Mo radionuclide as isopolymolybdate on gamma-irradiated aluminium oxide is very high and molybdenum is firmly retained. Adsorption capacity of gamma-irradiated aluminium oxide at pH 2-4 is 60-80 mg Mo per gram of Al 2 O 3 . The yields of 99m Tc from experimental generators remained high

Life Sciences at the Cyclotron Center of the Slovak Republic

International Nuclear Information System (INIS)

Podhorsky, D.; Kovac, P.; Macasek, F.

2004-01-01

In this presentation the history and present status of the Cyclotron Center of the Slovak (CC SR) are presented. A state run scientific center and production facility ensuring: - the basic and applied research in nuclear physics, chemistry, biology and medicine; - production of radionuclides and radiopharmaceuticals; - and applications of heavy ions and electron accelerator technologies in medicine and material science. Current financial status of the CC SR is following: Deblocation of the Russian; Federation debt to the Slovak Republic (94 %); State budget of the Slovak Republic (3 %); IAEA (3 %)

Vancouver Cyclotron Conference

International Nuclear Information System (INIS)

Clark, David J.

1993-01-01

Although no longer on the high energy frontier, the cyclotron field is still a major scientific growth area. Its progress is highlighted at the international conference on cyclotron design, development and utilization held at intervals of about three years, under the auspices of the International Union of Pure and Applied Physics (IUPAP). Vancouver, surrounded by mountains, water and some cyclotrons, provided a pleasant setting for the 13th Conference, held last summer. With over 200 cyclotrons in operation around the world, the attendance, 241 delegates and 26 industrial exhibitors, was a near record, reflecting the flourishing state of the field. The early sessions covered the initial operation of new or upgraded cyclotron facilities. Major facilities completed since the previous Conference in Berlin in May 1989 included the 400 MeV ring cyclotron at Osaka, the U400M cyclotron at Dubna which will be coupled to the U400 to give 20 MeV nucléon uranium beams, the 130 MeV cyclotron at Jyvaskyla (in Finland, the furthest north!), the 110 MeV JAERI machine in Japan, and the 65 MeV proton therapy cyclotron in Nice. Among the facility upgrades were the KFA cyclotron at Julich which will inject the 2.5 GeV storage ring COSY, and the addition of an FM mode to the K=200 CW mode at Uppsala to give protons up to 180 MeV. The impressive current of 1.5 mA at 72 MeV obtained from the PSI Injector II will soon be injected into the 590 MeV ring

The preparation of organic radiopharmaceuticals and labelled compounds using short-lived cyclotron-produced radionuclides

International Nuclear Information System (INIS)

Uhlenhut, G.J.; Koch, H.

1982-01-01

Accelerator-produced nuclides and radiopharmaceutical production are discussed with examples of pertinent methods of isotope production, methods of incorporation into organic molecules, and the general problems attandant on the production and use of these materials in this new and interdisciplinary effort. The literature is surveyed with stress being given to the use of 11 C, 13 N and 15 O. 205 references are included. (author)

Computer modeling of magnetic structure for IC-35 cyclotron

International Nuclear Information System (INIS)

Alenitskij, Yu.G.; Morozov, N.A.

1998-01-01

An extensive series of calculations has been carried out in order to design the magnetic structure of the IC-35 cyclotron for radioisotope production. The calculations were carried out by 2-D POISCR code. The average magnetic field and its variation were produced with the help of two different calculation models. The parameters of the cyclotron magnetic system are presented

Clinical diagnostic system using a small cyclotron for medical use

International Nuclear Information System (INIS)

Yonekura, Y.; Magata, Y.; Konishi, J.

1990-01-01

Since a small cyclotron and a positron emission tomography (PET) scanner have been installed at the Kyoto University Hospital in 1983, a great deal of effort has been directed to the clinical application of the PET-cyclotron system. This paper outlines the experience with PET in the clinical setting, including the facility, equipments and staff involved, weekly schedule, typical clinical protocols, and some results from the patients. The system consists of small cyclotron for production of the short-lived positron emitting radionuclides, fully automated synthesis system for labeling various compounds, scanning for measurement of radioactivities, and data analysis system for calculating physiological parameters. A resolving cylinder target system with eight smaller cylinders is equipped for production of C-11, N-13, O-15, and F-18. Labeled compounds are quickly delivered to the PET scanner room by two systems--the continuous delivery system for the labeled gas and the rapid delivery system for the liquid compounds by compressed air. A PET scanner devoted for clinical studies is a multislice whole-body PET scanner. Ten PET studies are performed weekly on the average for measuring blood flow and oxygen and glucose metabolism in the brain, blood flow and glucose and fatty acid metabolism in the heart, blood flow and amino acid uptake in the pancreas, lung ventilation, and tumor glucose metabolism. The availability of PET-cyclotron system is still limited in view of cost. The previous clinical studies suggest the contribution of PET to the the understanding of the mechanism of disease pathophysiology. (N.K.)

Radioisotope production with a medical cyclotron

International Nuclear Information System (INIS)

Silvester, D.J.

1974-01-01

The cyclotron of Hammersmith hospital in England was completed and started the operation in 1955. The feature is in its design operable at high beam current, reaching 500μA in internal beam and 300μA in external beam. In 1960's, twelve nuclides of radioactive pharmaceuticals were produced with the cyclotron. C-11, N-13 and O-15 have been used in the form of radioactive gases such as CO or H 2 O to test lung functions. F-18 has been used for bone scanning. K-43 is employed in the research of electrolyte balancing together with Na-24 and Br-77. Fe-52 is utilized in iron ion researches as a tracer. Cs-129 is highly evaluated as an isotope for imaging cardiac clogging part. Radioisotopes must be much more used in the examination of in vivo metabolic function. For this purpose, peculiarly labelled compounds should be further developed. It is welcome that the persons paying attention to the medical prospect of cyclotrons are increasing. The author hopes to continue his endeavour to find new products made with the cyclotron for human welfare. (Wakatsuki, Y.)

[Preparation, quality control and thyroid molecule imaging of solid-target based radionuclide ioine-124].

Science.gov (United States)

Zhu, H; Wang, F; Guo, X Y; Li, L Q; Duan, D B; Liu, Z B; Yang, Z

2018-04-18

To provide useful information for the further production and application of this novel radio-nuclide for potential clinical application. 124 Te (p,n) 124 I nuclide reaction was used for the 124 I production. Firstly, the target material, 124 TeO 2 (200 mg) and Al2O3 (30 mg) mixture, were compressed into the round platinum based solid target by tablet device. HM-20 medical cyclotron was applied to irradiate the solid target slice for 6-10 h with helium and water cooling. Then, the radiated solid target was placed for 12 h (overnight) to decay the radioactive impurity; finally, 124 I was be purified by dry distillation using 1 mL/min nitrogen for about 6 hours and radiochemical separation methods. Micro-PET imaging studies were performed to investigate the metabolism properties and thyroid imaging ability of 124 I.After 740 kBq 124 I was injected intravenously into the tail vein of the normal mice, the animals were imaged with micro-PET and infused with CT. The micro-PET/CT infusion imaging revealed actual state 124 I's metabolism in the mice. It was been successfully applied for 200 mg 124 TeO 2 plating by the tablet device on the surface of platinum. It showed smooth, dense surface and without obviously pits and cracks. The enriched 124 Te target was irradiated for 6 to 10 hours at about 12.0 MeV with 20 μA current on HM-20 cyclotron. Then 370-1 110 MBq 124 I could be produced on the solid target after irradiation and 370-740 MBq high specific activity could be collected afterdry distillation separation and radio-chemical purification. 124 I product was finally dissolved in 0.01 mol/L NaOH for the future distribution. The gamma spectrum of the produced 124 I-solution showed that radionuclide purity was over 80.0%. The micro-PET imaging of 124 I in the normal mice exhibited the thyroid and stomach accumulations and kidney metabolism, the bladder could also be clearly visible, which was in accordance with what was previously reported. To the best of our knowledge

Study of the activation of targets containing Mo for the production of 99Mo by the 98Mo(n,γ)99Mo nuclear reaction and the behaviour of the radionuclidic impurities of the process

International Nuclear Information System (INIS)

Nieto, Renata Correa

1998-01-01

The most used radioisotope in Nuclear Medicine is 99m Tc, in the 99 Mo- 99m Tc generator form. 99 Mo can be produced by several nuclear reactions in reactors and cyclotrons. The cyclotron production is not technically and economically viable. The production in the reactor can be done in two different ways: by the fission of 235 U and by 98 Mo(n,γ) 99 Mo reaction. A project for the production of 99 Mo by the activation of Mo and the preparation of gel type generators is under development at the 'Instituto de Pesquisas Energeticas e Nucleares'. In the present work, the radionuclidic impurities produced in the activation of MOO 3 and MoZr gel were evaluated, and these represent the two possible ways of preparing the gel of MoZr. A target of metallic Mo was also studied. The radionuclidic purity of 99m Tc eluted from generators prepared in these ways was also measured and compared with the generators prepared with fission 99 Mo. The results showed that, by all the parameters analysed, the best way of preparing the generator of 99 Mo - 99m Tc is the irradiation of MOO 3 and further preparation of the gel and the generators. (author)

Cyclotron Development and Technical Aspects on Accelerator Based Laboratory Development

International Nuclear Information System (INIS)

Sunarhadijoso

2000-01-01

BATAN is planning to establish an accelerator-based laboratory at P3TM Yogyakarta as an effort in the development and use of accelerator technology for improving industrial performance and public welfare. This paper reviews several aspects of cyclotron technology and describes the combination of a linear accelerator - cyclotron system as an alternative to be considered in the planing of the laboratory. The progress of cyclotron technology is discussed covering three generations, i.e. conventional cyclotron, synchrocyclotron and AVF cyclotron generations. The planning should not consider the accelerator application for radioisotope production because it is established in Serpong with the existing negative ion cyclotron. The proposed facility at P3TM may comprise two linear accelerators coupled with a positive ion cyclotron of synchrocyclotron generation. In fact, the attachment of the synchrocyclotron unit is flexible and it can be installed subsequently if the higher energy particle beam, which can not be produced by the linear accelerators, is extremely needed. Some technical aspects related to ion beam application, building construction and infrastructure, human resources, and specification of function test are discussed for additional information in the implementation of the planning. (author)

JSW's baby cyclotron

International Nuclear Information System (INIS)

Toda, Y.; Kaneda, Y.; Satoh, Y.; Suzukawa, I.; Yamada, T.

1983-01-01

Designed by The Japan Steel Works, Ltd., specially for installation in a hospital's medical department and nuclear research laboratory, '' JSW BABY CYCLOTRON '' has been developed to produce short-lived radioisotopes such as 11C, 13N, 15O and 18F. JSW's Baby Cyclotron has some design features. 1) Fixed energy and four sector azimuthally varying field. 2) Compact figure desired for hospital's nuclear medical department 3) A bitter type magnet yoke shielding activity 4) Simple control and operation 5) Easy maintenance without skilled personnel. Type BC105 (P:10MeV, d:5MeV), BC107 (P:10MeV, d:7MeV), BC168 (P:16MeV, d:8MeV) and BC1710 (P:17MeV, d:10MeV) are available according to required amount of radioisotopes. In our radioisotope production test, yield and purity of 11C, 13N, 15O and 18F are usable to clinical diagnosis

The Medical Cyclotron Facility in RMC, Parel, BARC

International Nuclear Information System (INIS)

Gopalakrishna, Arjun; Banerjee, Sharmila

2017-01-01

The Medical Cyclotron Facility in Radiation Medicine Centre (RMC) is the first one of its kind, installed in 2002. "1"8F based radiotracers are produced in this facility on a routine basis for Positron Emission Tomography (PET), of in-house patients, as well as for supply to other nuclear medicine centers in Mumbai as well as Pune. The facility consists of the following sub parts - Cyclotron and support equipment; Radiochemistry synthesis laboratory; Quality control (QC) laboratory

Optimisation of the radiation shielding of medical cyclotrons using a genetic algorithm

International Nuclear Information System (INIS)

Mukherjee, Bhaskar

2000-01-01

Effective radiation shielding is imperative for safe operation of modern Medical Cyclotrons producing large activities of short-lived radioisotopes on a commercial basis. The optimal cyclotron shielding design demands a careful balance between the radiological, economical and often the sociopolitical factors. One is required to optimize the cost of radiation protection and the cost of radiological-health detriment. The cost of radiation protection depends explicitly on a) the nature of the radiation field produced by the cyclotron, b) the cyclotron operation condition, c) the cost of shielding material, d) the level of dose reduction, e) the projected net revenue from the sale of the radioisotopes, and f) the depreciation rate of the cyclotron facility. The Genetic Algorithm (GA) is used for a cost -benefit analysis of this problem. The GA is a mathematical technique that emulates the Darwinian Evolution paradigm. It is ideally suited to search for a global optimum in a large multi-dimensional solution space, having demonstrated strength compared to the classical analytical methods. Furthermore the GA method runs on a PC in a Windows environment. This paper highlights an interactive spreadsheet macro program for the cost benefit analysis of the optimize Medical Cyclotron shielding using a GA search engine. (author)

MICHIGAN: Cyclotron conference

Energy Technology Data Exchange (ETDEWEB)

Anon.

1984-10-15

A sense of excitement was in the air as cyclotron physicists and engineers from 17 countries convened on 30 April for the opening of the Tenth International Conference on Cyclotrons and Their Applications. Some 50 years after its invention, the redoubtable cyclotron remains a topic of compelling current interest. Cyclotron experts gathered at Michigan State University's Kellogg Center to hear of latest developments, of progress and successes on new machines which had come into operation, of new projects which were underway, and of dreams which lay ahead.

Distribution of residual long-lived radioactivity in the inner concrete walls of a compact medical cyclotron vault room.

Science.gov (United States)

Fujibuchi, Toshioh; Nohtomi, Akihiro; Baba, Shingo; Sasaki, Masayuki; Komiya, Isao; Umedzu, Yoshiyuki; Honda, Hiroshi

2015-01-01

Compact medical cyclotrons have been set up to generate the nuclides necessary for positron emission tomography. In accelerator facilities, neutrons activate the concrete used to construct the vault room; this activation increases with the use of an accelerator. The activation causes a substantial radioactive waste management problem when facilities are decommissioned. In the present study, several concrete cores from the walls, ceiling and floor of a compact medical cyclotron vault room were samples 2 years after the termination of operations, and the radioactivity concentrations of radionuclides were estimated. Cylindrical concrete cores 5 cm in diameter and 10 cm in length were bored from the concrete wall, ceiling and floor. Core boring was performed at 18 points. The gamma-ray spectrum of each sample was measured using a high-purity germanium detector. The degree of activation of the concrete in the cyclotron vault room was analyzed, and the range and tendency toward activation in the vault room were examined. (60)Co and (152)Eu were identified by gamma-ray spectrometry of the concrete samples. (152)Eu and (60)Co are produced principally from the stable isotopes of europium and cobalt by neutron capture reactions. The radioactivity concentration did not vary much between the surface of the concrete and at a depth of 10 cm. Although the radioactivity concentration near the target was higher than the clearance level for radioactive waste indicated in IAEA RS-G-1.7, the mean radioactivity concentration in the walls and floor was lower than the clearance level. The radioactivity concentration of the inner concrete wall of the medical cyclotron vault room was not uniform. The areas exceeding the clearance level were in the vicinity of the target, but most of the building did not exceed the clearance levels.

Electromagnetic cyclotron harmonic waves

International Nuclear Information System (INIS)

Ohnuma, T.; Watanabe, T.; Hamamatsu, K.

1981-09-01

Electromagnetic electron cyclotron harmonic waves just below the electron cyclotron harmonics are investigated numerically and experimentally. Backward waves which are observed to propagate nearly perpendicular to the magnetic field just below the electron cyclotron frequency in a high density magnetoplasma are confirmed to be in accord with the theoretical electromagnetic cyclotron waves. (author)

The new solid target system at UNAM in a self-shielded 11 MeV cyclotron

International Nuclear Information System (INIS)

Zarate-Morales, A.; Gaspar-Carcamo, R. E.; Lopez-Rodriguez, V.; Flores-Moreno, A.; Trejo-Ballado, F.; Avila-Rodriguez, Miguel A.

2012-01-01

A dual beam line (BL) self-shielded RDS 111 cyclotron for radionuclide production was installed at the School of Medicine of the National Autonomous University of Mexico in 2001. One of the BL’s was upgraded to Eclipse HP (Siemens) in 2008 and the second BL was recently upgraded (June 2011) to the same version with the option for the irradiation of solid targets for the production of metallic radioisotopes.

MICHIGAN: Cyclotron conference

International Nuclear Information System (INIS)

Anon.

1984-01-01

A sense of excitement was in the air as cyclotron physicists and engineers from 17 countries convened on 30 April for the opening of the Tenth International Conference on Cyclotrons and Their Applications. Some 50 years after its invention, the redoubtable cyclotron remains a topic of compelling current interest. Cyclotron experts gathered at Michigan State University's Kellogg Center to hear of latest developments, of progress and successes on new machines which had come into operation, of new projects which were underway, and of dreams which lay ahead

On the coupling of cyclotron motion to ion internal degrees of freedom

International Nuclear Information System (INIS)

Dunbar, R.C.

1979-01-01

A possibility of significant coupling between gas-phase ion cyclotron motion and two internal angular momentum terms is explored. The first case, coupling with ion spin, is treated via the relativistic Hamiltonian, and found to produce only relativistic perturbations which are entirely negligible. The second case, coupling with ion rotation, is developed via its equivalence to a Stark effect. Small shifts in the cyclotron resonances frequency , ωsub(c) and the appearance of a weak cyclotron resonance at 2ωsub(c) are predicted, but these effects are negligible in general. If the cyclotron frequency is near an ion rotational transition, however, a shift of 10 -5 in cyclotron frequency may be observed, and could provide a means of investigating low-frequency rotational transitions of ions. (Auth.)

transfer factor of radionuclides from soil-to-palm oil produced

African Journals Online (AJOL)

Ogunjo Samuel

The activity concentration of the natural radionuclides were determined using a single crystal 0.51cm x 0.51cmNaI ... variety of food, cosmetic and hygiene products, and can be .... solubility of the radionuclide that may lead to high uptake or.

External injection systems applied in modern cyclotrons designed and manufactured in NIIEFA

International Nuclear Information System (INIS)

Bogdanov, P.V.; Vasilchenko, I.N.; Veresov, O.L.; Gavrish, Yu.N.; Grigorenko, S.V.; Zuev, Yu.V.; Kozienko, M.T.; Mudrolyubov, V.G.; Strokach, A.P.; Tsygankov, S.S.

2012-01-01

The main parameters and design features of the external injection systems applied in modern cyclotrons designed and manufactured in NIIEFA and intended for production of radionuclides for medicine are presented. The use of these external injection systems instead of a traditional internal source allows the current of the accelerated beam to be significantly increased and the in-leakage of the working gas to the acceleration chamber to be reduced, which results in reduced beam losses in the process of acceleration and lower equipment activation.

Radiation protection problems by the operation of the cyclotron facility

International Nuclear Information System (INIS)

Durcik, M.; Nikodemova, D.

1998-01-01

The Cyclotron Center in Bratislava will consist of two cyclotrons. First - cyclotron DC-72 with maximal energy of 72 MV for protons for making experiments, for teaching process, for radioisotope production as 123 I and for neutron and proton therapy. Second - compact cyclotron with maximal proton energy of 18 MeV will be used for radioisotopes production for medical diagnosis as 1 *F (fluorodeoxyglucose), 81 Rb/ 81 Kr generator. This paper deals with the radiation protection problems by the operation of tis cyclotron facility as radiation protection of workers, monitoring plan, ventilation, safety lock and limitation and radiation monitoring. For proposed and continuing practices at the accelerator facility, the following general principles have to be fulfilled: (1) practices should produce sufficient benefit to offset the radiation detriment they case (justification); (2) the magnitude of the individual doses should be kept as low as achievable (optimization of protection); (3) individual exposures are subject to dose limits and some control of risk from potential exposures (dose and risk limits)

Radiation exposure to workers at cyclotron facilities

International Nuclear Information System (INIS)

Ribeiro, M.S.; Sanches, M.P.; Sanchez, A.S.; Rodrigues, D.L.

2001-01-01

Radiopharmaceuticals quickly furnish the information doctors need to establish a precise diagnosis of the patient's condition, and therefore to prescribe the most effective therapy. In cancerology, F18-FDG, the most widely used PET imaging tracer, excels in the early detection of cancer tumors, even very tiny ones, which it locates and clearly distinguishes from healthy surrounding tissues. IPEN-CNEN/SP has two cyclotron accelerators used mainly for radioisotope production to be utilized in nuclear medicine for diagnosis and therapy. The first is a CV-28 cyclotron, variable energy that came into operation in 1982, which was used to produce F18-FDG and Iodine 123 up to 1998. The second, a Cyclone 30 cyclotron, 30 MeV, commenced operation in 1998 for certification purpose, and due to increase demand for radiopharmaceuticals in Brazil, started F18-FDG production in 1999. Cyclotron Laboratory will be a reference Research and Developing Center in our country and will help the Brazilian and Latin-American community. It is necessary to have an adequate database to allow regular follow up and analysis of the individual dose distributions for each group involved in the cyclotron activities. These databases are also important means to assess the effectiveness of efforts in order to maintain doses ALARA and reduce inequalities. The official individual occupational dosimetry is provided by certified Laboratory of Thermoluminescent Dosimetry at IPEN-CNEN/SP. This paper describes the occupational doses distribution in Laboratory of Cyclotrons at IPEN-CNEN/SP from January, 1998 to July, 2000 and propose improvements for the future. (author)

Cyclotron waves in plasma

CERN Document Server

Lominadze, D G

2013-01-01

Cyclotron Waves in Plasma is a four-chapter text that covers the basic physical concepts of the theory of cyclotron waves and cyclotron instabilities, brought about by the existence of steady or alternating plasma currents flowing perpendicular to the magnetic field.This book considers first a wide range of questions associated with the linear theory of cyclotron oscillations in equilibrium plasmas and in electron plasmas in metals and semiconductors. The next chapter deals with the parametric excitation of electron cyclotron oscillations in plasma in an alternating electric field. A chapter f

ECR heavy-ion source for the LBL 88-inch cyclotron

International Nuclear Information System (INIS)

Clark, D.J.; Kalnins, J.G.; Lyneis, C.M.

1983-03-01

An Electron Cyclotron Resonance (ECR) heavy-ion source is under construction at the LBL 88-Inch Cyclotron. This source will produce very-high-charge-state heavy ions, such as 0 8 + and Ar 12 + , which will increase cyclotron energies by a factor of 2-4, up to A = 80. It is a two-stage source using room-temperature coils, a permanent-magnet sextupole, and a 6-9 GHz microwave system. Design features include adjustable first-to-second-stage plasma coupling, a variable second-stage mirror ratio, high-conductance radial pumping of the second stage, and a beam-diagnostic system. A remotely movable extraction electrode will optimize extraction efficiency. The project includes construction of a transport line and improvements to the cyclotron axial-injection system. The construction period is expected to be two years

Regulatory requirements for designing PET-CT facility in India

International Nuclear Information System (INIS)

Tandon, Pankaj

2010-01-01

In India, cyclotron-produced radionuclides are gaining importance in molecular imaging in Nuclear Medicine (NM) departments. The importance of this modality among others is due to the fact that it provides valuable clinical information, which was lacking in other available modalities. Presently, every well-established hospital would like to procure Medical Cyclotron or positron emission tomography-computed tomography (PET-CT) facility in their NM department. Because cyclotron-produced radionuclides have higher energy than the other routinely used radionuclides for diagnosis, it becomes essential for the user to know about the regulatory requirement and radiation safety precautions that one has to take for the installation of this new modality in their premises. The various stages of approval of PET-CT facility by the Atomic Energy Regulatory Board (AERB) and important steps that one has to know/follow before planning for this new facility are summarized

Comparative study of ion cyclotron waves at Mars, Venus and Earth

Science.gov (United States)

Wei, H. Y.; Russell, C. T.; Zhang, T. L.; Blanco-Cano, X.

2011-08-01

Ion cyclotron waves are generated in the solar wind when it picks up freshly ionized planetary exospheric ions. These waves grow from the free energy of the highly anisotropic distribution of fresh pickup ions, and are observed in the spacecraft frame with left-handed polarization and a wave frequency near the ion's gyrofrequency. At Mars and Venus and in the Earth's polar cusp, the solar wind directly interacts with the planetary exospheres. Ion cyclotron waves with many similar properties are observed in these diverse plasma environments. The ion cyclotron waves at Mars indicate its hydrogen exosphere to be extensive and asymmetric in the direction of the interplanetary electric field. The production of fast neutrals plays an important role in forming an extended exosphere in the shape and size observed. At Venus, the region of exospheric proton cyclotron wave production may be restricted to the magnetosheath. The waves observed in the solar wind at Venus appear to be largely produced by the solar-wind-Venus interaction, with some waves at higher frequencies formed near the Sun and carried outward by the solar wind to Venus. These waves have some similarity to the expected properties of exospherically produced proton pickup waves but are characterized by magnetic connection to the bow shock or by a lack of correlation with local solar wind properties respectively. Any confusion of solar derived waves with exospherically derived ion pickup waves is not an issue at Mars because the solar-produced waves are generally at much higher frequencies than the local pickup waves and the solar waves should be mostly absorbed when convected to Mars distance as the proton cyclotron frequency in the plasma frame approaches the frequency of the solar-produced waves. In the Earth's polar cusp, the wave properties of ion cyclotron waves are quite variable. Spatial gradients in the magnetic field may cause this variation as the background field changes between the regions in which

Radioisotope production in the I. Ph. P. E. cyclotron for medical application

Energy Technology Data Exchange (ETDEWEB)

Krasnov, N.N.; Dmitriyev, P.P.; Konjakhin, N.A.; Ognev, A.A. (Gosudarstvennyj Komitet po Ispol' zovaniyu Atomnoj Ehnergii SSSR, Obninsk. Fiziko-Ehnergeticheskij Inst.)

1982-01-01

The production methods for seven radioisotopes, Ga-67, Sr-85, Pd-103, In-111, Tm-167, Hg-197 and Pb-203, by using a classical 1.5m cyclotron in the Institute of Physics and Power Engineering, Obninsk, USSR, are described. At present, more than 50 cyclotrons in different countries are used for the production of radioisotopes applied to medicine. Radioisotopes are produced with the cyclotron in the I.Ph.P.E. in the form of irradiated targets, which are delivered to Moscow radiopharmaceutical factory, where radiopharmaceuticals are produced on the base of these targets. The cyclotron is operated in two regimes providing the acceleration of protons, deuterons and alpha -particles. Two types of target assemblies are used for irradiation, the one is intended for the internal beam, and the other is for the external beam. The reactions used for the production of seven radioisotopes described above, the types of targets, particle energy, respective irradiated materials, beam current, thick target yield and the amount of respective radioisotopes produced per year are reported. Metals have large heat conductivity, therefore the use of metal targets increases beam current, and increases the production rate of radioisotopes.

Emergency situation in a medical cyclotron facility

International Nuclear Information System (INIS)

Kumar, Rajeev; Bhat, M.K.; Singh, D.K.; Pthania, B.S.; Pandit, A.G.; Jacob, M.J.

2010-01-01

Full text: Medical cyclotron is a particle accelerator used in producing short lived radioisotopes such as 18 F, 11 C, 15 O, 13 N, 18 F-2 gas etc. Positron Emission Tomography (PET) is a nuclear imaging modality that has rapidly gained favour. 18 F-FDG is the most widely used radiopharmaceutical with a half-life of 109.8 min. Having more than five years experience in this field we face lots of emergency conditions in the medical cyclotron facility. On the basis of harm we have divided in to three categories i.e. Harm of (a) working personnel, (b) Equipment and (c) environment. Radioactive gas leak and Target foil rupture is considered as the major emergency situations during medical cyclotron operations because there is a potential of over exposure to the working personnel. Radiation protection survey of a self-shielded medical cyclotron installation was carried out during normal and emergency conditions. It is found that the induced activity in the target foil increases with its successive usages. Recommendations have also been made to reduce personal exposure while handling the radioactive gas leak and target foil rupture conditions

Application of accelerator-produced short-lived radionuclides in industry

International Nuclear Information System (INIS)

Kupsch, H.

1986-01-01

Several problems such as corrosion, catalysis, wear, process optimization and diagnosis, damage analysis, arising in idustry can be solved using short-lived radioisotopes. Some examples of technological target designs which have been developed are demonstrated for the radionuclide production based on p,n; d,α; α,n; α,2n; α,p; γ,n; γ,p nuclear reactions. Applications of short-lived radionuclides in plants and processes of electrodeposition and gas concrete production are described. (author)

Cyclotron waves in plasma

International Nuclear Information System (INIS)

Lominadse, D.G.

1975-01-01

The book deals with fundamental physical concepts of the theory of cyclotron waves and cyclotron instabilities conditioned by the presence in plasma of direct or alternating electric currents passing in it perpendicularily to a magnetic field. A great variety of problems is considered connected with the linear theory of cyclotron oscillations in equilibrium and electron plasma of metals and semiconductors. Parametric excitations of electron cyclotron oscillations of plasma in an alternating electric field are studied. Particular attention is paid to the investigation of plasma turbulence arising as a result of development of cyclotron instabilities. Experimental data are discussed and compared with theoretical results

Cyclotrons: 1978

International Nuclear Information System (INIS)

Martin, J.A.

1978-01-01

A compilation is presented of the experimental facilities of the world's cyclotrons including history and status, staff and operation, research staff, target facilities, magnet, acceleration system, vacuum system, characteristic beams, beam properties, and a plan view of the facility for each cyclotron

Naturally Occurring Radionuclides of Ash Produced by Coal Combustion. The Case of the Kardia Mine in Northern Greece

Science.gov (United States)

Fotakis, M.; Tsikritzis, L.; Tzimkas, N.; Kolovos, N.; Tsikritzi, R.

2008-08-01

West Macedonia Lignite Center (WMLC), located in Northwest Greece, releases into the atmosphere about 21,400 tons/year of fly ash through the stacks of four coal fired plants. The lignite ash contains naturally occurring radionuclides, which are deposited on the WMLC basin. This work investigates the natural radioactivity of twenty six ash samples, laboratory produced from combustion of lignite, which was sampled perpendicularly to the benches of the Kardia mine. The concentrations of radionuclides 40K, 235U, 238U, 226Ra, 228Ra and 232Th, were measured spectroscopically and found round one order of magnitude as high as those of lignite. Subsequently the Radionuclide Partitioning Coefficients of radionuclides were calculated and it was found that they are higher for 232Th, 228Ra and 40K, because the latter have closer affinity with the inorganic matrix of lignite. During combustion up to one third of the naturally occurring radioisotopes escape from the solid phase into the flue gases. With comparison to relative global data, the investigated ash has been found to have relatively high radioactivity, but the emissions of the WMLC radionuclides contribute only 0.03% to the mean annual absorbed dose.

Naturally Occurring Radionuclides of Ash Produced by Coal Combustion. The Case of the Kardia Mine in Northern Greece

International Nuclear Information System (INIS)

Fotakis, M.; Tsikritzis, L.; Tzimkas, N.; Kolovos, N.; Tsikritzi, R.

2008-01-01

West Macedonia Lignite Center (WMLC), located in Northwest Greece, releases into the atmosphere about 21,400 tons/year of fly ash through the stacks of four coal fired plants. The lignite ash contains naturally occurring radionuclides, which are deposited on the WMLC basin. This work investigates the natural radioactivity of twenty six ash samples, laboratory produced from combustion of lignite, which was sampled perpendicularly to the benches of the Kardia mine. The concentrations of radionuclides 40 K, 235 U, 238 U, 226 Ra, 228 Ra and 232 Th, were measured spectroscopically and found round one order of magnitude as high as those of lignite. Subsequently the Radionuclide Partitioning Coefficients of radionuclides were calculated and it was found that they are higher for 232 Th, 228 Ra and 40 K, because the latter have closer affinity with the inorganic matrix of lignite. During combustion up to one third of the naturally occurring radioisotopes escape from the solid phase into the flue gases. With comparison to relative global data, the investigated ash has been found to have relatively high radioactivity, but the emissions of the WMLC radionuclides contribute only 0.03% to the mean annual absorbed dose

Evaluation of concentration limits of radionuclides produced by accelerators

International Nuclear Information System (INIS)

Shibata, Tokushi; Ohkubo, Tohru; Uwamino, Yoshitomo; Iwai, Satoshi; Satoh, Osamu; Rintsu, Yukoh; Fukumoto, Toshiharu.

1992-01-01

This report describes the evaluation of concentration limits of 78 radionuclides typically produced by accelerator facilities and not listed in ICRP Pub. 30. The evaluation method and system have been developed in the present study. The evaluated values were compared with tremendously severe concentration limits given in the Annex Table 2 of the Science and Technology Agency Notification No. 15 which describes the concentration limits of the nuclides of which concentration limits are not given in the Annex Table 1 of the Agency Notification No. 15. The results show that two to nine order larger limits should be used. The new limits rationalize greatly the internal exposure control and the design of accelerator facilities. Simple and convenient techniques are also discussed for finding concentration limits of very-short-lived nuclides without knowing detail information about the nuclides such as decay scheme and metabolic data. (author)

Cyclotrons as mass spectrometers

International Nuclear Information System (INIS)

Clark, D.J.

1984-04-01

The principles and design choices for cyclotrons as mass spectrometers are described. They are illustrated by examples of cyclotrons developed by various groups for this purpose. The use of present high energy cyclotrons for mass spectrometry is also described. 28 references, 12 figures

Radiation monitoring in a self-shielded cyclotron installation

International Nuclear Information System (INIS)

Capaccioli, L.; Gori, C.; Mazzocchi, S.; Spano, G.

2002-01-01

As nuclear medicine is approaching a new era with the spectacular growth of PET diagnosis, the number of medical cyclotrons installed within the major hospitals is increasing accordingly. Therefore modern medical cyclotron are highly engineered and highly reliable apparatus, characterised with reduced accelerating energies (as the major goal is the production of fluorine 18) and often self-shielded. However specific dedicated monitors are still necessary in order to assure the proper radioprotection. At the Careggi University Hospital in Florence a Mini trace 10 MeV self-shielded cyclotron produced by General Electric has been installed in 2000. In a contiguous radiochemistry laboratory, the preparation and quality control of 1 8F DG and other radiopharmaceuticals takes place. Aim of this work is the characterisation and the proper calibration of the above mentioned monitors and control devices

Medical applications of cyclotrons

International Nuclear Information System (INIS)

Jean, R.; Fauchet, M.

1978-01-01

Isochronous cyclotrons used to accelerate different charged particles (protons, deuterons, alphas...) at variable energies, have important medical applications, for neutron teletherapy, in vivo or in vitro activation analysis or production of short-lived radioisotopes for nuclear medicine. The characteristics of the cyclotron presently available are described for these three applications (low energy 'compact' cyclotrons, cyclotrons of intermediate and high energies), and their advantages are discussed from the points of view of the medical requirements, the financial investments and the results obtained. (orig.) [de

Future perspective of medical radionuclide production and related educational problems in developing countries

International Nuclear Information System (INIS)

Uenak, Turan

1999-01-01

The radionuclide applications are continuously escalation in nuclear medicine. Especially, the development of positron emission tomography (PET) technique has increased very rapidly the use of short-lived radioisotopes in this field, and this has caused the development of compact medical cyclotrons. About 30 cyclotrons operated in the world wide are actually found in the developing countries. In parallel of this progress, the basic nuclear sciences, especially nuclear chemistry and radiopharmaceutical chemistry will probably very important fields in the next new century for nuclear science and technology applications in health care sector. For this reason, the developing countries should eventually revise their academic educational and training programs aiming to ensure the formation of qualified basic nuclear scientists such as nuclear chemist, nuclear physicist, radiopharmacist, etc. (author)

Modeling of a cyclotron target for the production of 11C with Geant4.

Science.gov (United States)

Chiappiniello, Andrea; Zagni, Federico; Infantino, Angelo; Vichi, Sara; Cicoria, Gianfranco; Morigi, Maria Pia; Marengo, Mario

2018-04-12

In medical cyclotron facilities, 11C is produced according to the 14N(p,α)11C reaction and widely employed in studies of prostate and brain cancers by Positron Emission Tomography. It is known from literature [1] that the 11C-target assembly shows a reduction in efficiency during time, meaning a decrease of activity produced at the end of bombardment. This effect might depend on aspects still not completely known. Possible causes of the loss of performance of the 11C-target assembly were addressed by Monte Carlo simulations. Geant4 was used to model the 11C-target assembly of a GE PETtrace cyclotron. The physical and transport parameters to be used in the energy range of medical applications were extracted from literature data and 11C routine productions. The Monte Carlo assessment of 11C saturation yield was performed varying several parameters such as the proton energy and the angle of the target assembly with respect to the proton beam. The estimated 11C saturation yield is in agreement with IAEA data at the energy of interest, while is about the 35% greater than experimental value. A more comprehensive modeling of the target system, including thermodynamic effect, is required. The energy absorbed in the inner layer of the target chamber was up to 46.5 J/mm2 under typical irradiation conditions. This study shows that Geant4 is potentially a useful tool to design and optimize targetry for PET radionuclide productions. Tests to choose the Geant4 physics libraries should be performed before using this tool with different energies and materials. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

A new approach for manufacturing and processing targets to produce 99mTc with cyclotrons

Science.gov (United States)

Matei, L.; McRae, G.; Galea, R.; Niculae, D.; Craciun, L.; Leonte, R.; Surette, G.; Langille, S.; Louis, C. St.; Gelbart, W.; Abeysekera, B.; Johnson, R. R.

2017-06-01

The most important radioisotope for nuclear medicine is 99mTc. After the supply crisis of 99Mo starting in 2008, the availability of 99mTc became a worldwide concern. Alternative methods for producing the medical imaging isotope 99mTc are actively being developed around the world. The reaction 100Mo(p, 2n)99mTc provides a direct route that can be incorporated into routine production in nuclear medicine centers that possess medical cyclotrons for production of other isotopes, such as those used for Positron Emission Tomography. This paper describes a new approach for manufacturing targets for the (p, 2n) nuclear reaction on 100Mo and the foundation for the subsequent commercial separation and purification of the 99mTc produced. Two designs of targets are presented. The targets used to produce 99mTc are subject to a number of operational constraints.They must withstand the temperatures generated by the irradiation, accommodate temperature gradients from cooling system of the target, must be resilient and must be easily post-processed to separate the 99mTc. After irradiation, the separation of Tc from Mo was carried out using an innovative two-step approach. The process described in this paper can be automated with modules that easily fit in standard production hot cells found in nuclear medicine facilities.

Operation of a quasioptical electron cyclotron maser

International Nuclear Information System (INIS)

Morse, E.C.; Pyle, R.V.

1984-12-01

The electron cyclotron maser or gyrotron concept has been developed to produce sources producing 200 kW at 28 GHz continuously, and higher power outputs and frequencies in pulsed mode. These sources have been useful in electron cyclotron resonance heating (ECRH) in magnetically confined fusion devices. However, higher frequencies and higher power levels will be required in reactor-grade fusion plasmas, with likely requirements of 1.0 MW or more per source at 140 GHz. Conventional gyrotrons follow a trend of decreasing power for increasing frequency. In order to circumvent this problem, the quasioptical electron cyclotron maser was proposed. In this device, the closed resonator of the conventional gyrotron is replaced with an open, Fabry-Perot type resonator. The cavity modes are then the TEM-type modes of an optical laser. The advantage of this configuration is that the cavity size is not a function of frequency, since the length can be any half-integer number of wavelengths. Furthermore, the beam traverses across the cavity transverse to the direction of radiation output, and thus the rf window design is less complicated than in conventional tubes. The rf output, if obtained by diffraction coupling around one of the mirrors, could be in a TEM mode, which would allow for quasioptical transmission of the microwaves into the plasma in fusion devices. 4 references, 1 figure

Report of the 3rd RCM on Improved High Current Liquid and Gas Targets for Cyclotron Produced Radioisotopes

International Nuclear Information System (INIS)

2009-01-01

The overall objective of this CRP was the development of new accelerator targetry technology including several target systems but focusing on the reliable production of carbon-11 and fluorine-18 in various chemical forms with a view to increasing production yields, specific activity, improving the economics of production and the availability of the radiotracers. Significant advances have been made under this CRP in the development and standardization of high power gas and liquid targets. This CRP has resulted in the development of methods which can be used in high power targets to increase Carbon-11, Fluorine-18, Nitrogen-13, Iodine-123 and Krypton-81m, specific activities (a least a two fold increase), chemical purities as well as ensuring reliability of the production of the radiopharmaceuticals derived from these radionuclides. More importantly, these advances have minimized the unnecessarily operator exposure to radiation. In addition, knowledge of recovery and characterization of enriched H 2 18 O was also gained. Through this research the production capabilities with regard to [ 18 F]F - , [ 11 C]CO 2 and [ 11 C]CH 4 have increased 3 to 6 fold. A high current niobium target system has been designed, tested and put in service which could increase production capability of 18 FDG by a factor of 2.5. A survey of target maintenance procedures has been carried out and the results of this survey are reported in this CRP. It was determined that the tritium introduced by the inevitable nuclear reactions does not pose any health physics problems either during the tracer manufacturer or during potential water reclamation. It was further determined that radionuclides produced in the metal foil during irradiation are found in the target water at very low concentrations. These impurities can be essentially eliminated by using noble metal plated foils. The radionuclides can also be reduced by the separation technology typically used for fluorine extraction from the O-18

Positron emitting radionuclides for South Africa

International Nuclear Information System (INIS)

Wynchbank, S.; Van der Walt, T.N.; Sharpey-Shafer, J.

2004-01-01

Full text: In South Africa there are currently two projects underway to supply and utilise positron emitting radionuclides for imaging in clinical nuclear medicine facilities. The advantages and applications of such radio nuclides are numerous and well known. However the premier initial application will be to employ 1BF, at first in the compound fluorine-18 fluorodeoxyglucose ( 18 F)-FDG, for patients with cancers and neoplasms. The two projects are sited at iThemba LABS, where production of a generator supplying 66 Ga and the provision of ( 18 F]-FDG, are in an advanced state of planning; the former already fully financed by the Innovation Fund of the National Research Foundation. The two positron emitting radionuclides, 18 F and 68 Ge, will be produced using a cyclotron induced reaction on 1802 and Ga, respectively, at iThemba LABS. The 68 Ge/ 68 Ga generator consists of an anion exchanger loaded with 68 Ge, which decays to 68 Ga. The resulting radiopharmaceuticals, ( 18 F]-FDG and 68 Ga citrate, will be produced by the Radionuclide Production Group of iThemba LABS, using well described methods. However the structures and processes to be used in the generator to provide 68 Ga are novel and will be explained. Initially provision of the CBF]-FDG will be to selected clinical medicine facilities in the Western Cape and Gauteng. It should be noted that the logistical problems of providing this radiopharmaceutical (which are much complicated by its short half life of 109.7 min) to Gauteng, were shown to be surmountable in the 1970s, by a regular delivery of 18 F between Gauteng and Cape Town, after the advent of a commercial service using jet aircraft. The obvious requirement that there should be appropriate nuclear medicine facilities to image patients, at the sites to which the positron emitting radiopharmaceuticals will be supplied, has been addressed. Proposed solutions will be outlined, in terms of a dedicated positron emission tomography (PET) camera and a gamma

Potential of cyclotron based accelerators for energy production and transmutation

Energy Technology Data Exchange (ETDEWEB)

Stammbach, T.; Adam, S.; Fitze, H.R. [Paul Scherrer Institute, Villigen (Switzerland)] [and others

1995-10-01

PSI operates a 590 MeV-cyclotron facility for high intensity proton beams for the production of intense beams of pions and muons. The facility, commissioned in 1974, has been partially upgraded and is now operated routinely at a beam current of 1 mA, which corresponds to a beam power of 0.6 MW. At this current, the beam losses in the cyclotron are about 0.02%. By the end of 1995 the authors expect to have 1.5 mA of protons. Extensive theoretical investigations on beam current limitations in isochronous cyclotrons were undertaken. They show that the longitudinal space charge effects dominate. Based on their experience the authors present a preliminary design of a cyclotron scheme that could produce a 10 MW beam as a driver for an {open_quotes}energy amplifier{close_quotes} as proposed by C. Rubbia and his collaborators. The expected efficiency for the conversion of AC into beam power would be about 50% (for the RF-systems only). The beam losses in the cyclotron are expected to be a few {mu}A, leading to a tolerable activation level.

Preparation and characterization of radionuclide 64Cu for positron emission tomographic diagnosis and therapy

International Nuclear Information System (INIS)

Ometakova, J.

2013-01-01

We occupy ourselves with preparation of 64 Cu using cyclotron IBA 18/9. 64 Cu is a starting product for production of radiopharmaceuticals for positron emission tomographic diagnostics and therapy and metrological characterization as well. The use of non-traditional PET radionuclides has been spread in the world recently. Due to the physical properties (T 1/2 =12.7 h, β- 37.1 %, β + 17.9 %), 64 Cu is suitable for therapy (β - ) and diagnosing as well (β+). 64 Cu is suitable radionuclide for labeling of radiopharmaceuticals on the basis of bis-thiosemicarbazone for study of hypoxic tumors. The number and orientation of articles and papers at conferences show a great demand for 64 Cu in the world. It is caused by specific physical properties and possibility of preparation in small biomedical cyclotrons as well. An electrolytic preparation of a target lies in a galvanostatic plating of 64 Ni on a gold target. The target is irradiated by a cyclotron IBA Cyclone 18/9. COSTIS station (Compact Solid Target Irradiation System) is installed at the end of external proton beam. 64 Cu is separated from the target material by ionex Bio-Rad AG1-X8 as [ 64 Cu]CuCl 2 . The target material is recycled by a simple method. A process of 64 Cu preparation is completely automated and runs in a separation module with Plc Simatin S-1200 developed by Biont a.s. The product was measured by an ionization chamber (Curiementor), HPGe detector and LSC method (TDCR). (author)

Preparation and characterization of radionuclide 64Cu for positron emission tomographic diagnosis and therapy

International Nuclear Information System (INIS)

Ometakova, J.

2013-01-01

We occupy ourselves with preparation of 64 Cu using cyclotron IBA 18/9. 64 Cu is a starting product for production of radiopharmaceuticals for positron emission tomographic diagnostics and therapy and metrological characterization as well. The use of non-traditional PET radionuclides has been spread in the world recently. Due to the physical properties (T 1/2 =12.7 h, β- 37.1 %, β + 17.9 %), 64 Cu is suitable for therapy (β - ) and diagnosing as well (β+). 64 Cu is suitable radionuclide for labeling of radiopharmaceuticals on the basis of bis-thiosemicarbazone for study of hypoxic tumors. The number and orientation of articles and papers at conferences show a great demand for 64 Cu in the world. It is caused by specific physical properties and possibility of preparation in small biomedical cyclotrons as well. An electrolytic preparation of a target lies in a galvanostatic plating of 64 Ni on a gold target. The target is irradiated by a cyclotron IBA Cyclone 18/9. COSTIS station (Compact Solid Target Irradiation System) is installed at the end of external proton beam. 64 Cu is separated from the target material by ionex Bio-Rad AG1-X8 as [ 64 Cu]CuCl 2 . The target material is recycled by a simple method. A process of 64 Cu preparation is completely automated and runs in a separation module with PLC SIMATIC S7-1200 developed by Biont a.s. The product was measured by an ionization chamber (Curiementor), HPGe detector and LSC method (TDCR). (author)

Pumping system of 30,000 l/sec for CIME cyclotron

International Nuclear Information System (INIS)

Horbowa, A.; Buhler, S.; Blache, Ph.; Chevrollier, R.; Grolet, D.; Pilot, A.; Szott, Ph.; Languiller, J.; Gallardo, Ph.

1999-01-01

The cyclotron CIME (SPIRAL facilities) has to accelerate radioactive ions produced from primary heavy beams delivered by GANIL. To avoid beam losses by charge exchange on the residual gas, the ultimate pressure in the cyclotron is expected to be better than 5.10 -8 mbar. In order to reach such a low pressure, a system of 30.000 l/sec twin cryo-panels has been designed for being installed inside the cyclotron. Each cryo-panel will be individually cooled by a separate set of two cryo-generators. From cryo-generators to cryo-panels, the cooling power is transferred through heat-pipes over several meters. The complete system designed and constructed in the IPN and GANIL laboratories, is presently under testing at the GANIL location. (authors)

Medical radioisotopes production at the isochronous cyclotron in Alma-Ata

International Nuclear Information System (INIS)

Arzumanov, A.A.; Batischev, V.N.; Gladun, V.K.; Kochetkov, V.L.

1988-01-01

High efficiency cyclotron operations (up to 5200 hours of beam time a year) considerably increased the possibility to perform both fundamental and applied scientific work. There appeared possibility to accelerate protons in a wide energy range from 6 to 30 MeV and realize correspondingly the nuclear reactions up to (A, 3n). This paper reports that among different applied tasks performed at the cyclotron the special program of cyclotron production of short-lived medical radioisotopes iodine-123, thallium-201, cadmium-109 in the first place and some others to satisfy clinic needs of Alma-Ata and its region has special importance. In accordance with this program the preparation to produce iodine-123 is being held and regular production of Thallium chloride, thallium-201 pharmaceptical is started

Project of positron source at the U-120 Cyclotron, Bucharest. Status report

International Nuclear Information System (INIS)

Racolta, P.M.; Popa Simil, L.; Voiculescu, Dana; Miron, N.

1999-01-01

To extend the applications with our U-120 Cyclotron we started a project of off-line and on-line positron sources produced at the cyclotron. This machine may be successfully used for producing positron sources with few day half-life for off-line positron studies (eg. 48 V), or a cyclotron on-line intense positron beam (eg. 27 Si) with a variable energy for various materials study experiments, enough to cover a depth range from few micrometers down to tens of nanometers. Until now, using a 48 V positron source we performed experiments for determination of the Doppler broadening of the 511 KeV peak for different materials (copper, lead, indium). This research is carrier out on a cooperation agreement between IFIN-HH Bucharest and LISES-Chisinau. The positron source project is now in its initial stage. This stage consists of the experiments on the off-line version using positron sources produced in the cyclotron (eg. 48 V, 22 Na), to develop experience with detection chains (Doppler broadening and positron annihilation lifetime spectroscopy), to choose proper experiments in order to select moderator materials (W, Mo, Pt, etc.) and to study and design the different versions for the on-line production of positrons with the cyclotron. Slow positrons are valuable tools in atomic physics, materials science and solid state physics research. The controlled energy beam facility can be used to probe defects in metals, to study Fermi surfaces and materials surfaces and interfaces and to obtain detailed information about the electronic structure of materials. The aim of this project is to perform applications in the semiconductor industry, for coating materials, polymers, biomaterials etc. (authors)

Project of positron source at the U-120 cyclotron Bucharest status report

International Nuclear Information System (INIS)

Racolta, P.M.; Simil Popa, L.; Voiculescu, Dana; Miron, N.

2000-01-01

To extend the applications with our U-120 Cyclotron we started a project of off-line positron sources produced at the cyclotron. This machine may be successfully used for producing positron sources with few day half-life for off-line positron studies (e.g. 48 V), or a cyclotron on-line intense positron beam (e.g. 27 Si) with a variable energy for various materials study experiments, enough to cover a depth range from a few micrometers down to tens of nanometers. Until now, using a 48 V positron source we performed experiments for determination of the Doppler broadening of the 511 keV peak for different materials (copper, lead, indium). This research is carried out on a cooperation agreement between IFIN-HH Bucharest and LISES-Chisinau. The positron source project is now in its initial stage. This stage consists of the experiments on the off-line version using positron source produced in the cyclotron (e.g. 48 V, 22 Na), to develop experience with detection chains (Doppler broadening and positron annihilation lifetime spectroscopy) to choose proper experiments in order to select moderator materials (W, Mo, Pt, etc.) and to study and design the different versions for the on-line positron production by cyclotron. Slow positrons are valuable tools in atomic physics, materials science and solid state physics research. The controlled energy beam facility can be used to probe defects in metals, to study Fermi surfaces and materials surfaces and interfaces and to obtained detailed information about electronic structures of materials. The aim of this project is to perform applications in the semiconductor industry, for coating materials, polymers, biomaterials, etc. (authors)

40. anniversary of cyclotron of Institute of Nuclear Physics, Tashkent

International Nuclear Information System (INIS)

Umerov, R.A.; Uzakov, J.M.; Gulamov, I.R.

2004-01-01

and manufacture of radioisotopes. The further reconstruction of the accelerator was required: intensity of a beam was increased up to 600 microampere. With this purpose were developed and made new plates, duants, target station. The technology of an irradiation of the targets was mastered maintaining the big thermal loadings. In 1991 on the basis of a Cyclotron U-150-II, were created Scientific Technological Enterprise (STE) 'TEZLATGICH' producing isotopes, basically Cobalt-57, and Joint Uzbek-German Enterprise 'TEZINKO' through which delivery of radioactive isotopes for foreign countries. The Cyclotron became independent division and bringing significant currency receipts to the state. STE 'TEZLATGICH' has increased the nomenclature of producing isotopes, such as Cd-109, Pd-103

Radioisotope production by reactors and cyclotrons in Japan

International Nuclear Information System (INIS)

Murakami, Yukio

1978-01-01

Present status of radioisotope production in Japan and the increasing demand from various fields are generally reviewed. Future problems associated with the shortage of economical supply are also discussed. The first half of this report is devoted to general review of the increasing demand for various radioisotopes from increasing number of users. The present status and future trends of the distribution of users of specific radioisotopes and their demands are shown. The remaining half of this report reviews the production with reactors and cyclotrons. The Japanese reactors producing radioisotopes are limited to low flux (10 13 ) research reactors at JAERI. Some problems associated with the improvement of availability and with the organizational structure are discussed. As for the production with cyclotrons, available facilities and the method of production are explained in detail. For clinical use, especially for the production of short lived radioisotopes, the advantage of a small special purpose cyclotron at each medical organization is emphasized. (Aoki, K.)

Monitoring of radionuclides in carbon steel blooms produced by EAF process

Directory of Open Access Journals (Sweden)

Sofilić T.

2011-01-01

Full Text Available Because natural and artificial isotopes in steel might originate from steel scrap or from the residue of the material that was used in the technological process, thus monitoring especially artificial radionuclides 60Co, 137Cs and 192Ir deserve special attention. The analysis by g-spectrometry has been applied to determine the presence of natural isotopes 40K, 226Ra, 232Th and 238U as well as of the artificial isotope 60Co, 137Cs and 192Ir and their activity in the produced steel round blooms in the Steel Mill of CMC Sisak d.o.o. At the same time the content of radionuclides in the other materials (ferroalloys, bauxite, fluorite, lime, coke, graphite electrodes, refractory blocks used in the same steel making process was investigated. The measured values regarding the presence of individual isotopes and their activity in steel were as follows: 40K all values were less than 1.6 Bqkg-1; 232Th all activities values were less than 0.02 Bqkg-1; 226Ra all activities values were less than 0.01 Bqkg-1; 238U all activities values were less than 1.10 Bqkg-1; 60Co all activities values were less than 0.02 Bqkg-1; 192Ir all activities values were less than 0.02 Bqkg-1 and 137Cs all activities values were less than 0.30 Bqkg-1.

Water, soil, crops and radionuclides. Studies on the behavior of radionuclides in the terrestrial environments

International Nuclear Information System (INIS)

Uchida, Shigeo

2008-01-01

In order to predict the migration of artificially-produced radionuclides into a human body and its radiation dose rates of human body and to decrease the exposed radiation doses of human body, the behavior of radionuclides in the environment must be elucidated. In National Institute of Radiological Sciences (NIRS), the environmental radioecological research group of Nakaminato Laboratory for Marine Radioecology has progressed the survey and research on the behavior of artificially-produced radionuclides in the terrestrial environment. This article describes the research results (the radioactivity of water, soil, and crops) made so far at Nakaminato Laboratory for Marine Radioecology. (M.H.)

Speciation analysis of radionuclides

International Nuclear Information System (INIS)

Salbu, B.

2010-01-01

Full text: Naturally occurring and artificially produced radionuclides in the environment can be present in different physico-chemical forms (i. e. radionuclide species) varying in size (nominal molecular mass), charge properties and valence, oxidation state, structure and morphology, density, complexing ability etc. Low molecular mass (LMM) species are believed to be mobile and potentially bioavailable, while high molecular mass (HMM) species such as colloids, polymers, pseudocolloids and particles are considered inert. Due to time dependent transformation processes such as mobilization of radionuclide species from solid phases or interactions of mobile and reactive radionuclide species with components in soils and sediments, however, the original distribution of radionuclides deposited in ecosystems will change over time and influence the ecosystem behaviour. To assess the environmental impact from radionuclide contamination, information on radionuclide species deposited, interactions within affected ecosystems and the time-dependent distribution of radionuclide species influencing mobility and biological uptake is essential. The development of speciation techniques to characterize radionuclide species in waters, soils and sediments should therefore be essential for improving the prediction power of impact and risk assessment models. The present paper reviews fractionation techniques which should be utilised for radionuclide speciation purposes. (author)

Induction of mutations in antibiotic-producing microorganisms by fast neutrons from the U-120 cyclotron

International Nuclear Information System (INIS)

Wolf, J.; Huczkowski, J.; Siejka, D.; Krasnowolski, S.; Brodowicz, M.

1976-01-01

The purpose of this study was to investigate the activity of fast neutrons from a U-120 cyclotron in the induction of mutations in streptomycetes, resulting in strains with enhanced antibiotic production. Three streptomycete strains producing the antibiotics: lincomycin, moenomycin, and demethylchlorotetracycline were used. Correlation between the survival rate of spores of the examined strains and neutron dose was determined. Several morphological and physiological features (particularly production of antibiotics for 1543 variants derived from the parent strains) and their distribution within the population were also studied. The survival rate of the streptomycetes spores after irradiation with fast neutrons was found to be an individual strain property. Several variants with considerably increased antibiotic yield were isolated. The results are compared with those obtained after treatment with other mutagens. Several variants of one of the strains with a strongly enhanced antibiotic yield (200-220%) were isolated. No such variants were found after UV irradiation. (author)

Production of medical short-lived radionuclides in Canada

International Nuclear Information System (INIS)

Wiebe, L.I.

1985-01-01

The production of radionuclides for medical and biomedical research in Canada has been reviewed with respect to the national geographic and demographic characteristics which influence their use. The types of facilities available for the production of short-lived radionuclides have been summarized, and a tabulation of the radionuclides that are produced has been presented. In broad terms production facilities can be classified as belonging to one of two groups, nuclear reactor or charged-particle accelerators. The charged-particle accelerators produce the more neutron-deficient and (because of the resultant decay properties) the more useful radionuclides for medical application. The nuclear reactor facilities for radionuclide production range in size and capacity from the high-flux research reactors of AECL to the six SLOWPOKE reactors, five of which are located on university campuses across the country. The McMaster University reactor is used to produce curie quantities of fluorine-18 weekly. Millicurie amounts of a large number of radionuclides, most of which have half-lives ranging from 2 to 50 hr, are produced in the low-flux reactors, in support of basic medical research

Production of Radioisotopes in Pakistan Research Reactor: Past, Present and Future

International Nuclear Information System (INIS)

Mushtaq, A.

2013-01-01

Radioisotope production to service different sectors of economic significance constitutes an important ongoing activity of many national nuclear programs. Radioisotopes, formed by nuclear reactions on targets in a reactor or cyclotron, require further processing in almost all cases to obtain them in a form suitable for use. The availability of short-lived radionuclides from radionuclide generators provides an inexpensive and convenient alternative to in-house radioisotope production facilities such as cyclotrons and reactors. The reactor offers large volume for irradiation, simultaneous irradiation of several samples, economy of production and possibility to produce a wide variety of radioisotopes. The accelerator-produced isotopes relatively constitute a smaller percentage of total use. (author)

New development of neutron radiography with a small cyclotron

International Nuclear Information System (INIS)

Ikeda, Yasushi; Ohkubo, Kohei; Kato, Toshihiko; Nakamura, Tomihisa; Fuji, Takayoshi.

1990-01-01

A series of neutron radiography testing has been performed for several years by using a small accelerator called 'Baby Cyclotron' manufactured by Japan Steel Works, Ltd. The Baby Cyclotron produces fast neutrons at the rate of 4x10 12 n/cm 2 s, and enables to perform neutron radiography imaging by various techniques. The most important application of this Baby Cyclotron radiography system is the non-destructive testing (NDT) of various explosive devices prepared for space launch vehicles. It is assured that thermal neutron radiography testing is a very useful means for the NDT. Also fast neutron radiography testing is in progress. The fast neutron radiography with a CR39 track-etch image recorder was developed, and it was shown to be the very useful NDT means when the thicker objects used for new H-2 launch vehicles had to be examined. Because thermal neutron radiography has the high detectability of hydrogenous materials, organic elastomers such as O-rings and explosive powder are clearly observable through the opaque steel walls of containers. The Baby Cyclotron and the neutron radiography facility, thermal neutron and fast neutron radiography testings and so on are reported. (K.I.)

Injection and extraction for cyclotrons

International Nuclear Information System (INIS)

Heikkinen, P.

1994-01-01

External ion sources for cyclotrons are needed for polarised and heavy ions. This calls for injection systems, either radial or axial. Radial injection is also needed when a cyclotron works as a booster after another cyclotron or a linear accelerator (usually tandem). Requirements for injection differ from separated sector cyclotrons where there is plenty of room to house inflectors and/or strippers, to superconducting cyclotrons where the space is limited by a small magnet gap, and high magnetic field puts other limitations to the inflectors. Several extraction schemes are used in cyclotrons. Stripping injection is used for H - and also for heavy ions where the q/m ratio is usually doubled. For other cases, electric and magnetic deflection has to be used. To increase the turn separation before the first deflector, both resonant and non-resonant schemes are used. In this lecture, external injection systems are surveyed and some rules to thumb for injection parameters are given. Extraction schemes are also reviewed. (orig.)

Cyclotrons for isotope production

International Nuclear Information System (INIS)

Milton, B.F.; Stevenson, N.R.

1995-06-01

Cyclotrons continue to be efficient accelerators for radioisotope production. In recent years, developments in the accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicates a strong future for commercial cyclotrons. In this paper we will survey recent developments in the areas of cyclotron technology, and isotope production, as they relate to the new generation of commercial cyclotrons. We will also discuss the possibility of systems capable of extracted energies up to 100 MeV and extracted beam currents of up to 2.0 mA. (author). 6 refs., 2 tabs., 3 figs

Design study of an ultra-compact superconducting cyclotron for isotope production

Science.gov (United States)

Smirnov, V.; Vorozhtsov, S.; Vincent, J.

2014-11-01

A 12.5 MeV, 25 μA, proton compact superconducting cyclotron for medical isotope production has been designed and is currently in fabrication. The machine is initially aimed at producing 13N ammonia for Positron Emission Tomography (PET) cardiology applications. With an ultra-compact size and cost-effective price point, this system will offer clinicians unprecedented access to the preferred radiopharmaceutical isotope for cardiac PET imaging. A systems approach that carefully balanced the subsystem requirements coupled to precise beam dynamics calculations was followed. The system is designed to irradiate a liquid target internal to the cyclotron and to minimize the need for radiation shielding. The main parameters of the cyclotron, its design, and principal steps of the development work are presented here.

Isochronous cyclotron data base description

International Nuclear Information System (INIS)

Kiyan, I.N.; Vorozhtsov, S.B.; Tarashkevich, R.

2004-01-01

The relational data base of the control parameters of the isochronous cyclotron, Isochronous Cyclotron Data Base (ICDB), is described. The relational data base under consideration, written in Transact SQL for the MS SQL Server 2000 with the use of MS Enterprise Manager and MS Query Analyzer, was installed on the server of the AIC144 isochronous cyclotron in Krakow, which operates under the control of the operating system MS Windows Server 2003 (Standard Edition). The interface of the data base under considerations is written in C++ with the use of Visual C++ .NET and is built in the Cyclotron Operator Help Program (COHP), which is used for modeling the operational modes of the isochronous cyclotron. Communication between the COHP and the relational data base is realised on the base of the Open Data Base Connectivity protocol. The relational data base of the control parameter of the isochronous cyclotron is intended: firstly, for systematization and automatic use of all measured and modelled magnetic field maps in the process of modeling the operational modes; secondly, for systematization and convenient access to the stored operational modes; thirdly, for simplifying the operator's work. The relational data base of the control parameter of the isochronous cyclotron reflects its physical structure and the logic of its operator's work. (author)

Determination of cosmic ray produced radionuclides by means of background radiation counting system, 3

International Nuclear Information System (INIS)

1976-01-01

This is the third report of the progress report series on studies of cosmic ray produced radionuclides by means of low background radiation counting system. In Part I some characteristics of a low beta-gamma coincidence spectrometer are described -- counter system, electronics, background spectra, counting efficiencies -- and studies on radioactive impurities in materials for scientific research are also described. In Part II, suitable solvents for a large scale liquid scintillation counter were examined and best combinations of solvents, solutes and naphthalene are shown. In Part III, miscellaneous topics are reported. (auth.)

Cyclotron spectra from inhomogeneous accretion columns. II. Polarization

International Nuclear Information System (INIS)

Wu, K.; Chanmugam, G.

1989-01-01

Circularly and linearly polarized radiation from inhomogeneous cyclotron emission regions with uniform magnetic field and temperature but different electron density profiles are studied. Calculations show that the inhomogeneous models generally produce larger polarization for low harmonics and smaller polarization for high harmonics compared to the homogeneous models. Polarization light curves for different inhomogeneous models with a wide variety of parameters are presented, providing handy theoretical results to compare with observations. The observed polarization light curves of ST LMi, EF Eri, and BL Hydri are fitted using an inhomogeneous model for the first time, and good fits are obtained, supporting the hypothesis that the cyclotron emission regions of AM Her systems have a complicated structure. 37 refs

Fourier Transform Ion Cyclotron Resonance Mass Spectrometry at the Cyclotron Frequency.

Science.gov (United States)

Nagornov, Konstantin O; Kozhinov, Anton N; Tsybin, Yury O

2017-04-01

The phenomenon of ion cyclotron resonance allows for determining mass-to-charge ratio, m/z, of an ensemble of ions by means of measurements of their cyclotron frequency, ω c . In Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), the ω c quantity is usually unavailable for direct measurements: the resonant state is located close to the reduced cyclotron frequency (ω + ), whereas the ω c and the corresponding m/z values may be calculated via theoretical derivation from an experimental estimate of the ω + quantity. Here, we describe an experimental observation of a new resonant state, which is located close to the ω c frequency and is established because of azimuthally-dependent trapping electric fields of the recently developed ICR cells with narrow aperture detection electrodes. We show that in mass spectra, peaks close to ω + frequencies can be reduced to negligible levels relative to peaks close to ω c frequencies. Due to reduced errors with which the ω c quantity is obtained, the new resonance provides a means of cyclotron frequency measurements with precision greater than that achieved when ω + frequency peaks are employed. The described phenomenon may be considered for a development into an FT-ICR MS technology with increased mass accuracy for applications in basic research, life, and environmental sciences. Graphical Abstract ᅟ.

ROKCY-12 (KCCH PET-dedicated cyclotron): main features and improvements

International Nuclear Information System (INIS)

Chai, J. S.; Kim, Y. S.; Yang, Y. T.; Jung, I. S.; Hong, S. S.; Lee, M. Y.; Jang, H. S.; Kim, J. H.

2002-01-01

In this paper, we describe the development of 13 MeV cyclotron (ROKCY-12) that can be used for a Position Emission Tomography(PET) purpose. This cyclotron with a maximum beam energy of 13 MeV can produce radio isotopes especially 18 F which has a relatively short half lifetime of 110 minutes. First, we show the beam characteristics can be used to carry out the operation of ROCKY-12. Based on this, a computer program has been developed to determine main cyclotron parameters such as cyclotron magnet, RF system, ion source, vacuum system and other cyclotron operation parameters. And then we show the result of design and manufacturing feature of ROKCY-12. By using this design program, one can determines magnet yoke geometry and the average magnetic fields etc. And then the three-dimensional computer program OPERA-3D has been invoked to determine magnet pole tips. Validity of the design can be seen by investigating magnetic fields, radial and vertical focusing frequencies as a function of the beam energy. In this paper, we show the results of cyclotron beam by ROCKY-12. We designed 77.3 MHz RF system and ion source system. We tested RF resonance each coupling methods. We show the result of RF design and prototype operation. Developed ion source is PIG type. We described our design methods and implementation. We report the result of getting negative hydrogen ion. Cyclotron controller asks inputs of every sensor and output of every instrument for notifying current condition to operator. It has independent controllers, for example DC power supply, vacuum system, beam profile system, beam extraction system, RF system, ion source, cooling unit and so on. Basically, each control system uses RS-485 for communication to main control computer. Consumers reward products and services that feature quality, originality, a distinct personality and charm. The International Standardization Organization (ISO) requires, as its mission, that we achieve competitive superiority by

Gaseous radioactive effluent restrictions, measurement, and minimization at a PET/cyclotron facility

International Nuclear Information System (INIS)

Plascjak, P.S.; Kim, K.K.; Googins, S.W.; Meyer, W.C. Jr.

1993-01-01

In the US, restrictions on the release of radioactive effluents from PET (positron emission tomography)/cyclotron facilities are typically imposed by State regulatory agencies and may be based on various methodologies and limits published by numerous agencies. This work presents suitable effluent concentration limits for various chemical forms of radioisotopes routinely produced in PET/cyclotron facilities. They were determined by application of metabolic models defined by ICRP 53 and ICRP 26/30 which will result in compliance with effective dose equivalent limits of 100 mrem per year at the release point. The NIH Cyclotron Facility effluent air monitoring system, environmental dosimetry program, and simple, effective systems for radioactive effluent minimization are also described. (orig.)

Advances in superconducting cyclotrons at MSU

International Nuclear Information System (INIS)

Blosser, H.; Antaya, T.; Au, R.

1987-01-01

Intensive work on superconducting cyclotrons began at MSU in late 1973 (a brief earlier study had occurred in the early 1960's) and continues vigorously at present. One large cyclotron, the ''K500'', has been operating for a number of years, a second, the ''K800'', is nearing completion, the first operating tests of its magnet having occurred at the time of the previous conference, and a third, the ''medical cyclotron'', is now also nearing completion with first operation of its magnet expected just after the present conference. These cyclotrons like other superconducting cyclotrons are all dramatically smaller than comparable room temperature machines; overall weight is typically about 1/20th of that of room temperature cyclotrons of the same energy. This large reduction in the quantities of materials is partially offset by added complexity, but finally, a net overall cost savings of 50 to 70 % typically results; as a consequence the superconducting cyclotron is widely viewed as the cyclotron of the future. The thirteen years of experience at MSU involving three of these cyclotrons, together with much important work at other laboratories, gives a rather clear view of the advantages and disadvantages of various design approaches including by now a rather significant period of long term evaluation. This paper reviews highlights of this program. (author)

Medical cyclotron facilities

International Nuclear Information System (INIS)

1984-09-01

This report examines the separate proposals from the Austin Hospital and the Australian Atomic Energy Commission for a medical cyclotron facility. The proponents have argued that a cyclotron facility would benefit Australia in areas of patient care, availability and export of radioisotopes, and medical research. Positron emission tomography (PET) and neutron beam therapy are also examined

Nuclear applications in life sciences

International Nuclear Information System (INIS)

Uenak, P.

2009-01-01

Radioactivity has revolutionized life sciences during the last century, and it is still an indispensable tool. Nuclear Medicine, Radiation Biology and Radiotherapy, Dosimetry and Medical Radiation Physics, Nutrition and Environmental Problems Relevant Health are significant application fields of Nuclear Sciences. Nuclear medicine today is a well established branch of medicine. Radionuclides and radiopharmaceuticals play a key role both in diagnostic investigations and therapy-Both cyclotron and reactor produced radionuclides find application, the former more in diagnostic studies and the latter in therapy. New therapy applications such as bor neutron therapy are increasing by time together with the technological improvements in imaging systems such as PET and SPECT. Radionuclides and radiopharmaceuticals play important role in both therapy and imaging. However cyclotron produced radionuclides have been using generally in imaging purposes while reactor produced radionuclides have also therapeutic applications. With the advent of emission tomography, new vistas for probing biochemistry in vivo have been opened. The radio chemist faces an ever-increasing challenge of designing new tracers for diagnostic and therapeutic applications. Rapid, efficient and automated methods of radionuclide and precursor production, labeling of biomolecules, and quality control need to be developed. The purpose of this article is a short interface from Nuclear Medicine, Radiation Biology and Radiotherapy, Dosimetry and Medical Radiation Physics Applications of Nuclear Sciences.

Atmospheric tracer tests and assessment of a potential accident at the National Medical Cyclotron, Camperdown, NSW, Australia

International Nuclear Information System (INIS)

Clark, G.H.; Bartsch, F.J.K.; Stone, D.J.M.

1994-08-01

In order to assess the impact of a potential atmospheric release of radionuclides from the National Medical Cyclotron facility, in Camperdown, an atmospheric tracer release, sampling and analysis system using SF 6 was developed. During eight experiments conducted in a variety of meteorological conditions, ten samplers were located in the vicinity of the Cyclotron building and other nearby buildings on the rapid downward movement of the tracer gas plume. The atmospheric dilution factors which lead to the highest observed air concentrations were then applied to the releases of I 123 and Xe 123 from a potential accident scenario in order to assess the impact on nearby receptors. Even given the conservative assumptions about the release of I 123 , the estimated radiation doses were at least an order of magnitude below the international standards for doses to member of the public. 27 refs., 8 tabs., 5 figs

Atmospheric tracer tests and assessment of a potential accident at the National Medical Cyclotron, Camperdown, NSW, Australia

Energy Technology Data Exchange (ETDEWEB)

Clark, G H; Bartsch, F J.K.; Stone, D J.M.

1994-08-01

In order to assess the impact of a potential atmospheric release of radionuclides from the National Medical Cyclotron facility, in Camperdown, an atmospheric tracer release, sampling and analysis system using SF{sub 6} was developed. During eight experiments conducted in a variety of meteorological conditions, ten samplers were located in the vicinity of the Cyclotron building and other nearby buildings on the rapid downward movement of the tracer gas plume. The atmospheric dilution factors which lead to the highest observed air concentrations were then applied to the releases of I{sup 123} and Xe{sup 123} from a potential accident scenario in order to assess the impact on nearby receptors. Even given the conservative assumptions about the release of I{sup 123}, the estimated radiation doses were at least an order of magnitude below the international standards for doses to member of the public. 27 refs., 8 tabs., 5 figs.

ORNL-Safeguards and security: The Global producers of the 8 radionuclides of particular security concern

OpenAIRE

Carman, James (UTK); Creel, Althea (UTK); Milewski, Steven (UTK); Staub, James (UTK); Woofter, Angela (UTK); GreyNet, Grey Literature Network Service

2004-01-01

To gather the available open source information about the worldwide producers of the radionuclides that could be used in a radiological dispersal device or "dirty bomb" was the objective of this project. This report was the culminating project for a group of students in the Business Intelligence course taught by Dr. Kendra Albright in spring 2004 at the School of Information Sciences at the University of Tennessee, Knoxville. The major focus of this Business Intelligence course was to give st...

Development of Medical Cyclotron in KIRAMS

International Nuclear Information System (INIS)

Chai, Jong Seo; Jung, In Su; An, Dong Hyun

2005-01-01

This paper is presented on the development and status of medical cyclotron at the Korea Institute of Radiological and Medical Sciences (KIRAMS) at present. We have developed medical cyclotron which is KIRAMS-13. And the improvement of KIRAMS-13 is presented. Furthermore, the design of new cyclotrons, such as KIRAMS-5 and KIRAMS-30 cyclotron, are presented, and R and D studies for future plan of heavy ion accelerator are discussed

Ion cyclotron-resonance heating in a toroidal octupole

International Nuclear Information System (INIS)

Barter, J.D.; Sprott, J.C.

1975-01-01

rf power near the ion cyclotron-resonance frequency has been used to produce a hundredfold increase (from approximately-less-than1 to approx.100 eV) in the ion temperature in a toroidal octupole device. The heating produces no noticeable instabilities or other deleterious effects except for a high reflux of neutrals from the walls. The heating rate is consistent with theory and the limiting ion temperature is determined by charge-exchange losses

All-magnetic extraction for cyclotron beam reacceleration

Science.gov (United States)

Hudson, E.D.; Mallory, M.L.

1975-07-22

An isochronous cyclotron can be modified to provide an initial electron stripping stage, a complete acceleration of the stripped ions through the cyclotron to a first energy state, means for returning the ions to an intermediate cyclotron orbit through a second stripping stage, further acceleration of the now higher energy stripped ions through the cyclotron to their final energy, and final extraction of the ions from the cyclotron. (auth)

Future cyclotron systems : an industrial perspective

International Nuclear Information System (INIS)

Stevenson, N.R.; Dickie, W.J.

1995-09-01

The use of commercial cyclotron systems for the production of radioisotopes continues to grow on a world-wide scale. Improvements in technology have significantly increased the production capabilities of modem cyclotron-based isotope production facilities. In particular, the change to negative ion acceleration and new high power systems have resulted in dramatic improvements in reliability, increases in capacity, and decreases in personnel radiation dose. As more and more older machines are retired decisions regarding their replacement are made based on several factors including the market's potential and the cyclotron system's abilities. Taking the case of the recently upgraded TR30 cyclotron at TRIUMF/Nordion, we investigate the requirements industrial/medical users are likely to impose on future commercial cyclotron systems and the impact this will have on cyclotron technology by the end of the century. (author)

Future cyclotron systems: An industrial perspective

International Nuclear Information System (INIS)

Stevenson, N.R.; Dickie, W.J.

1995-09-01

The use of commercial cyclotron systems for the production of radioisotopes continues to grow on a world-wide scale. Improvements in technology have significantly increased the production capabilities of modern cyclotron-based isotope production facilities. In particular, the change to negative ion acceleration and new high power systems have resulted in dramatic improvements in reliability, increases in capacity, and decreases in personnel radiation dose. As more and more older machines are retired, decisions regarding their replacement are made based on several factors including the market's potential and the cyclotron system's abilities. Taking the case of the recently upgraded TR30 cyclotron at TRIUMF/Nordion, the authors investigate the requirements industrial/medical users are likely to impose on future commercial cyclotron systems and the impact this will have on cyclotron technology by the end of the century

Report of the 3{sup rd} RCM on Improved High Current Liquid and Gas Targets for Cyclotron Produced Radioisotopes

Energy Technology Data Exchange (ETDEWEB)

NONE

2009-07-01

The overall objective of this CRP was the development of new accelerator targetry technology including several target systems but focusing on the reliable production of carbon-11 and fluorine-18 in various chemical forms with a view to increasing production yields, specific activity, improving the economics of production and the availability of the radiotracers. Significant advances have been made under this CRP in the development and standardization of high power gas and liquid targets. This CRP has resulted in the development of methods which can be used in high power targets to increase Carbon-11, Fluorine-18, Nitrogen-13, Iodine-123 and Krypton-81m, specific activities (a least a two fold increase), chemical purities as well as ensuring reliability of the production of the radiopharmaceuticals derived from these radionuclides. More importantly, these advances have minimized the unnecessarily operator exposure to radiation. In addition, knowledge of recovery and characterization of enriched H{sub 2} {sup 18}O was also gained. Through this research the production capabilities with regard to [{sup 18}F]F{sup -}, [{sup 11}C]CO{sub 2} and [{sup 11}C]CH{sub 4} have increased 3 to 6 fold. A high current niobium target system has been designed, tested and put in service which could increase production capability of {sup 18}FDG by a factor of 2.5. A survey of target maintenance procedures has been carried out and the results of this survey are reported in this CRP. It was determined that the tritium introduced by the inevitable nuclear reactions does not pose any health physics problems either during the tracer manufacturer or during potential water reclamation. It was further determined that radionuclides produced in the metal foil during irradiation are found in the target water at very low concentrations. These impurities can be essentially eliminated by using noble metal plated foils. The radionuclides can also be reduced by the separation technology typically used

Light ions cyclotron bombardment to simulate fast neutron radiation damage in nuclear materials

International Nuclear Information System (INIS)

Segura, E.; Lucki, G.; Aguiar, D.

1984-01-01

The applicability and limitations of the use of cyclotron light ions bombardment to simulate the effects of the neutron irradiation are presented. Light ions with energies of about 10 MeV are capable to produce homogeneous damage in specimens suitable for measuring bulk mechanical properties although their low damage rate of 10 -5 dpa.sec -1 limit the dose range to a few dpa. On the other hand, cyclotron alpha particle implantation provides a fast and convenient way of introducing helium with a minimum of side effects so that we can take advantage of this technique to get better understanding of the mechanism by which this insoluble gas produces high temperature embrittlement. Some experimental details such as dimensions and cooling techniques are described. Finally a description of the infrastructure for cyclotron alpha particle implantation and a creep-test facility of the Division of Radiation Damage at IPEN-CNEN/SP are presented. (Author) [pt

Ernest Orlando Lawrence (1901-1958), Cyclotron and Medicine

Energy Technology Data Exchange (ETDEWEB)

Chu, William T.

2005-09-01

, constructed a 13-cm diameter model that had all the features of early cyclotrons, accelerating protons to 80,000 volts using less than 1,000 volts on a semi-circular accelerating electrode, now called the ''dee''. Following the discovery by J. D. Cockcroft and E. T. S. Walton of how to produce larger currents at higher voltages, Lawrence constructed the first two-dee 27-Inch (69-cm) Cyclotron, which produced protons and deuterons of 4.8 MeV. The 27-Inch Cyclotron was used extensively in early investigations of nuclear reactions involving neutrons and artificial radioactivity. In 1939, working with William Brobeck, Lawrence constructed the 60-Inch (150-cm) Cyclotron, which accelerated deuterons to 19 MeV. It was housed in the Crocker Laboratory, where scientists first made transmutations of some elements, discovered several transuranic elements, and created hundreds of radioisotopes of known elements. At the Crocker Laboratory the new medical modality called nuclear medicine was born, which used radioisotopes for diagnosis and treatment of human diseases. In 1939 Lawrence was awarded the Nobel Prize in Physics, and later element 103 was named ''Lawrencium'' in his honor.

Use of maze in cyclotron hoppers; Utilizacao de labirinto em bunker de ciclotron

Energy Technology Data Exchange (ETDEWEB)

Fernandes, Fernando A.; Alves, Juliano S.; Fochesatto, Cintia; Cerioli, Luciane; Borges, Joao Alfredo; Gonzalez, Delfin; Silva, Daniel C., E-mail: fernandofernandes@biofarmaco.com.br [Delfin Farmacos e Derivados (Biofarmaco Marcadores Moleculares), Lauro de Freitas, BA (Brazil)

2013-07-01

Introduction: the increasing number of cyclotrons in Brazil due to constitutional amendment 49 /06 that enabled the production of radiopharmaceuticals with a short half - life by private companies. The radionuclides used for PET - CT require production centers near or within the diagnostic centers. In order to minimize maintenance and operating risks, gaining efficiency, our facility was the first in Brazil to use the access to a cyclotron bunker via maze, rather than armored door stopper type. Materials: the design calculations were based on the Monte Carlo method (MCNP5 - Monte Carlo N-Particletransportcode version 5). At the ends of the labyrinth are installed a door of polyethylene, for thermalization of neutrons, and other of wood for limiting access. Both legs of the maze have wall thickness of 100cm. In inspection Brazilian CNEN realize measures of dose rate for neutrons and gamma 9 points: 7 around the bunker, 1 over the bunker and 1 in the exhaust with the cyclotron operating with maximum load, double beam of 50uA for 2 hours. After commissioning were carried out around the bunker, the following measures: cumulative dose in three months with dosimeters for neutron rate dose with a gas proportional detector type filled with {sup 3}He and polyethylene neutron moderator and dose rate with a Geiger - Mueller detector for gamma radiation. Readings with neutron detectors were classified as background radiation and dose rates were always below the limits established in standard EN 3.01, and the calculation of the predicted regardless of the intensity of irradiation inside the bunker. Conclusion: the use of labyrinths as a way to access the bunkers cyclotron has been shown to be effective as the radiation shielding and efficient by allowing quick and easy access, virtually eliminating the maintenance.

Operational experience and recent developments at the National Medical Cyclotron

International Nuclear Information System (INIS)

Conard, E.; Pac, B.; Arnott, D.W.

1994-01-01

The National Medical Cyclotron is a radioisotope production facility run by ANSTO and located on the grounds of the Royal Prince Alfred Hospital in Sydney, Australia. A CYCLONE 30 (IBA) cyclotron is used in the production of short-lived PET radiopharmaceuticals required by the hospital's PET Scanner and also to produce a number of bulk radiochemicals for processing and distribution throughout Australasia. Following commissioning of the cyclotron and beam lines in October 1991, and the overcoming of a number of early open-quote teething close-quote problems especially relating to the reliability of the r.f. and solid target transport systems, a steady program of improvements has been pursued. These improvements have included development of new beam diagnostics and the design and installation of a new beam line for SPECT radioisotope production. The current operations schedule includes the production of 18 FDG, 13 NH 3 , 15 O 2 and 201 Tl, 67 Ga and 123 I. This paper will discuss the process of development of the cyclotron to ably meet the present demands on it, and the problems resolved in the pursuit of this goal

Implementation of a metrology programme to provide traceability for radionuclides activity measurements in the CNEN Radiopharmaceuticals Producers Centers

Energy Technology Data Exchange (ETDEWEB)

Andrade, Erica A.L. de; Braghirolli, Ana M.S.; Tauhata, Luiz; Gomes, Regio S.; Silva, Carlos J., E-mail: erica@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Delgado, Jose U.; Oliveira, Antonio E.; Iwahara, Akira, E-mail: ealima@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

2013-07-01

The commercialization and use of radiopharmaceuticals in Brazil are regulated by Agencia Nacional de Vigilancia Sanitaria (ANVISA) which require Good Manufacturing Practices (GMP) certification for Radiopharmaceuticals Producer Centers. Quality Assurance Program should implement the GMP standards to ensure radiopharmaceuticals have requirements quality to proving its efficiency. Several aspects should be controlled within the Quality Assurance Programs, and one of them is the traceability of the Radionuclides Activity Measurement in radiopharmaceuticals doses. The quality assurance of activity measurements is fundamental to maintain both the efficiency of the nuclear medicine procedures and patient and exposed occupationally individuals safety. The radiation doses received by patients, during the nuclear medicine procedures, is estimated according to administered radiopharmaceuticals quantity. Therefore it is very important either the activity measurements performed in radiopharmaceuticals producer centers (RPC) as the measurements performed in nuclear medicine services are traceable to national standards. This paper aims to present an implementation program to provide traceability to radionuclides activity measurements performed in the dose calibrators(well type ionization chambers) used in Radiopharmaceuticals Producer Center placed in different states in Brazil. The proposed program is based on the principles of GM Pand ISO 17025 standards. According to dose calibrator performance, the RPC will be able to provide consistent, safe and effective radioactivity measurement to the nuclear medicine services. (author)

Production of exotic beams at the LBL 88-Inch Cyclotron by the ISOL method

International Nuclear Information System (INIS)

1990-04-01

The Users of the LBL 88-Inch Cyclotron are preparing a proposal to produce exotic, i.e., radioactive beams. The facility will consist of a high-current 30 MeV cyclotron to generate the radioactive nuclei, an ECR source that can be coupled to different production targets, and the 88-Inch Cyclotron to accelerate the radioactive ions. Thus, the basic concept is that of the double cyclotron system pioneered at Louvain-la-Neuve, although the initial emphasis will be on producing a variety of light proton-rich beams at energies up to 10 MeV/A. At this workshop we wish to outline what is being planned, to invite comments and suggestions, and, especially, to encourage participation. We believe that this facility will be an important step toward establishing the scientific and technical basis for a National High Intensity Facility. This can be achieved through active participation by members of the radioactive beam (RB) community in (1) experiments with high quality radioactive beams of moderate intensity and, (2) R ampersand D on high beam-power targets and highly efficient ion sources. 5 refs., 4 figs

Ion Cyclotron Heating on Proto-MPEX

Science.gov (United States)

Goulding, R. H.; Caughman, J. B. O.; Rapp, J.; Biewer, T. M.; Campbell, I. H.; Caneses, J. F.; Kafle, N.; Ray, H. B.; Showers, M. A.; Piotrowicz, P. A.

2016-10-01

Ion cyclotron heating will be used on Proto-MPEX (Prototype Material Plasma Exposure eXperiment) to increase heat flux to the target, to produce varying ion energies without substrate biasing, and to vary the extent of the magnetic pre-sheath for the case of a tilted target. A 25 cm long, 9 cm diameter dual half-turn helical ion cyclotron antenna has been installed in the device located at the magnetic field maximum. It couples power to ions via single pass damping of the slow wave at the fundamental resonance, and operates with ω 0.8ωci at the antenna location. It is designed to operate at power levels up to 30 kW, with a later 200 kW upgrade planned. Near term experiments include measuring RF loading at low power as a function of frequency and antenna gap. The plasma is generated by a helicon plasma source that has achieved ne > 5 ×1019m-3 operating with deuterium, as measured downstream from the ion cyclotron antenna location. Measurements will be compared with 1-D and 2-D models of RF coupling. The latest results will be presented. This manuscript has been authored by UT-Battelle, LLC, under Contract No. DE-AC05-00OR22725 with the U.S. Department of Energy.

National cyclotron centre at the Institute for Nuclear Research and Nuclear Energy

Science.gov (United States)

Tonev, D.; Goutev, N.; Asova, G.; Artinyan, A.; Demerdjiev, A.; Georgiev, L. S.; Yavahchova, M.; Bashev, V.; Genchev, S. G.; Geleva, E.; Mincheva, M.; Nikolov, A.; Dimitrov, D. T.

2018-05-01

An accelerator laboratory is presently under construction in Sofia at the Institute for Nuclear Research and Nuclear Energy. The laboratory will use a TR24 type of cyclotron, which provides a possibility to accelerate a proton beam with an energy of 15 to 24 MeV and current of up to 0.4 mA. An accelerator with such parameters allows to produce a large variety of radioisotopes for development of radiopharmaceuticals. The most common radioisotopes that can be produced with such a cyclotron are PET isotopes like: 11C, 13N, 15O, 18F, 124I, 64Cu, 68Ge/68Ga, and SPECT isotopes like: 123I, 111In, 67Ga, 57Co, 99mTc. Our aim is to use the cyclotron facility for research in the fields of radiopharmacy, radiochemistry, radiobiology, nuclear physics, materials sciences, applied research, new materials and for education in all these fields including nuclear energy. Presently we perform investigations in the fields of target design for production of radioisotopes, shielding and radioprotection, new ion sources etc.

New Cyclotron Targetry to Enhance F-18 clinical Position Emission Tomography

International Nuclear Information System (INIS)

Doster, J. Michael

2008-01-01

This project proposes to develop cyclotron targets that produce F-18 for clinical Positron Emission Tomography (PET) at significantly higher rates than that available from current targetry. This production rate of 18F is directly proportional to the beam current. Higher beam currents would result in increased 18F production but would be accompanied by higher heat loads to the target. The beam power available in most commercial cyclotrons exceeds the heat removal capacity of current target technology by a factor of two to four, significantly limiting the production rate of Fluorine-18

Computer design of a compact cyclotron

International Nuclear Information System (INIS)

Bing Wang; Huanfeng Hao; Qinggao Yao; Jinquan Zhang; Mingtao Song; Vorozhtsov, S.B.; Smirnov, V.L.; Hongwei Zhao

2011-01-01

Here we present results of the computer design of the structural elements of a compact cyclotron by the example of HITFiL cyclotron selected as the driving accelerator that is under construction at the Institute of Modern Physics (Lanzhou, China). In the article a complex approach to modeling of the compact cyclotron, including calculation of electromagnetic fields of the structural elements and beam dynamics calculations, is described. The existing design data on the axial injection, magnetic, acceleration and extraction systems of the cyclotron are used as a starting point in the simulation. Some of the upgrades of the cyclotron structural elements were proposed, which led to substantial improvement of the beam quality and transmission

Reactor and /or accelerator: general remarks on strategic considerations in sourcing/producing radiopharmaceuticals and radiotracer for the Philippines

International Nuclear Information System (INIS)

Nazarea, A.D.

1996-01-01

The most important sources of radionuclides in the world are particle accelerators and nuclear reactors. Since the late 1940's many radiotracers and radiopharmaceuticals have been innovated and conceived, designed, produced and applied in important industrial and clinical/ biomedical settings. For example in the health area, reactor-produced radionuclides have become indispensable for diagnostic imaging involving, in its most recent and advanced development, radioimmunoscintigraphy, which exploits the exquisite ligand-specificity of monoclonal antibodies, reagents which in turn are the products of advances in biotechnology. Thus far, one of the most indispensable radiopharmaceuticals has been 99m Tc, which is usually obtained as a daughter decay product of 99 Mo. In January 1991, some questions about the stability of the worldwide commercial supply of 99 Mo became highlighted when the major commercial world producer of 99 Mo, Nordion International, shut down its facilities temporarily in Canada due to contamination in its main reactor building (see for instance relevant newsbrief in J. Nuclear Medicine (1991): 'Industry agrees to join DOE study of domestic moly-99 production'). With the above background, my remarks will attempt to open discussions on strategic considerations relevant to questions of 'self reliance' in radiotracers/radiopharmaceutical production in the Philippines. For instance, the relevant question of sourcing local radionuclide needs from a fully functioning multipurpose cyclotron facility within the country that will then supply the needs of the local industrial, biomedical (including research) and health sectors; and possibly, eventually acquiring the capability to export to nearby countries longer-lived radiotracers and radiopharmaceuticals

The Cyclotron Center of the Slovak Republic

International Nuclear Information System (INIS)

Podhorsky, D.; Ruzicka, J.; Macasek, F.; Makaiova, I.; Saro, S.; Kristiak, J.; Fulup, M.

2001-01-01

The Cyclotron Center of the Slovak Republic was established at the beginning of August 1999 - within the Slovak-Office of Standards, Metrology and Testing (SOSMT), in Bratislava, Slovak Republic. It will have two cyclotrons - a large heavy and light cyclotron DC-72, which will be constructed by the Joint Institute for Nuclear Research (JINR), Dubna, Russian Federation, and a small commercial light ion cyclotron IBA 18/9. The heavy ion source of the electron resonance type (DECRS-2M) will be used for low and medium energy experiments in physics. The small electron accelerator is planned for different applications, including improving the properties of plastics, increasing the resistance of cables to fire and temperature, the sterilization of medical disposables in the CC SR. The main purpose of the Cyclotron Center of the Slovak Republic (CC SR) is to catch the present approach and trends in the area of improving of inhabitants life and health quality using the progressive technology, which is introduced by bringing into practice of the physical equipment - accelerators, producing beams of high energy particles. Experts of nuclear physics and of the related branches have no experimental basis in Slovakia, as after dissolution of the former the Czech and Slovak Federal Republic all bigger nuclear equipment were left in the Czech Republic. The Slovak Republic is one of the European countries where cancer and cardiovascular diseases have a rapidly increasing tendency (the rate of new oncological cases is approximately 20,000/year at the population of 5 million inhabitants) - early diagnostics of population is necessary to be updated urgently. The Slovak Republic use a great part of electricity (about 60 %) from its own nuclear power stations and thus it is in need of education of rising generations of experts from different nuclear fields. The Government of the Slovak republic on June 18, 1996 approved the strategic aim of building up the Cyclotron Laboratory at the

Startup work on Inshas cyclotron

International Nuclear Information System (INIS)

Vorogushin, M.F.; Strokach, A.P.; Shikhov, V.Ya.; Galchuk, A.V.; Soliman, A.N.; El-Abyad, M.; Comsan, M.N.H.; Saleh, Z.A.; Azzam, A.N.

2001-01-01

Startup works on the MGC-20 variable energy cyclotron in the Inshas Nuclear Research Center (Egypt) are described. The cyclotron is intended for acceleration of hydrogen and helium ions in a wide energy range (for protons - from 5 to 20 MeV). Main units of the cyclotron and results of computer experimental acceleration of protons to 18 MeV are described. The prospects of furthers investigations are presented [ru

Cyclotrons as Drivers for Precision Neutrino Measurements

International Nuclear Information System (INIS)

Alonso, J.; Barletta, W. A.; Winslow, L. A.; Shaevitz, M. H.; Spitz, J.; Conrad, J. M.; Toups, M.; Adelmann, A.

2014-01-01

As we enter the age of precision measurement in neutrino physics, improved flux sources are required. These must have a well defined flavor content with energies in ranges where backgrounds are low and cross-section knowledge is high. Very few sources of neutrinos can meet these requirements. However, pion/muon and isotope decay-at-rest sources qualify. The ideal drivers for decay-at-rest sources are cyclotron accelerators, which are compact and relatively inexpensive. This paper describes a scheme to produce decay-at-rest sources driven by such cyclotrons, developed within the DAEδALUS program. Examples of the value of the high precision beams for pursuing Beyond Standard Model interactions are reviewed. New results on a combined DAEδALUS—Hyper-K search for CP violation that achieve errors on the mixing matrix parameter of 4° to 12° are presented

Production of Cobalt-57 from irradiation of proton beams on nickel at CV-28 cyclotron of IPEN-CNEN/SP

International Nuclear Information System (INIS)

Santos, Liliane Landini Mota; Osso Junior, Joao Alberto

1996-01-01

The 57 Co is produced at the Cyclotron of IPEN-CNEN/SP through the irradiation of natural Nickel with a protons beam of 24 MeV energy. The aim of this work was to measure the thick target production yield of 57 Co and of its principal radionuclide impurities and the determination of the excitation functions of the nuclear reactions on Ni, to evaluate the best conditions for the 57 Co production. The technique used was of the stacked-foil, of Ni, Cu and Al, being the two latter utilized as current and energy monitors of the protons beam, respectively. The thick target production yield of 57 Co, through the somatory of indirect and direct reaction, 11,31 days after E.O.B., was 905,76 kBq/μA.h (24,48 μCi/μA.h) and only by indirect reaction was 174,64 kBq/μA.h (4,72 μCi/μA.h). (author)

Cyclotron production of {sup 44}Sc for clinical application

Energy Technology Data Exchange (ETDEWEB)

Krajewski, S.; Bilewicz, A. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Cydzik, I. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); European Commission Joint Research Center, Ispra (Italy). Inst. for Health and Consumer Protection; Warsaw Univ. (Poland). Heavy Ion Lab.; Abbas, K. [European Commission Joint Research Center, Ispra (Italy). Institute for Transuranium Elements; Bulgheroni, A.; Simonelli, F.; Holzwarth, U. [European Commission Joint Research Center, Ispra (Italy). Inst. for Health and Consumer Protection

2013-08-01

{sup 44} is a promising {beta}{sup +}-emitter for molecular imaging with intermediate half-life of 4 h. Due to the chemical similarity of Sc{sup 3+} to the Lu{sup 3+} and Y{sup 3+} cations, {sup 44}Sc-DOTA bioconjugates are expected to demonstrate similar properties in vivo as the {sup 177}Lu- and {sup 90}Y-bioconjugates, what is important in planning the radionuclide therapy. {sup 44}Sc can be obtained from the {sup 44}Ti/{sup 44}Sc generator. An alternative method for {sup 44}Sc production can be the irradiation of {sup 44}Ca target at small cyclotrons. The aim of our work was to optimize the parameters of {sup 44}CaCO{sub 3} irradiation and to develop a simple procedure for {sup 44}Sc separation from the calcium target. For optimization study, {sup 44}CaCO{sub 3} targets were irradiated by protons in the energy range of 5.6-17.5 MeV with 9 MeV being found to be the best energy for {sup 44}Ca irradiations. A simple and fast separation procedure of {sup 44}Sc from calcium target was developed using chelating resin Chelex 100. DOTATATE conjugate was successfully radiolabelled with high yield at elevated temperature using the produced {sup 44}Sc. While {sup 44}CaCO{sub 3} is relatively expensive, the cost of {sup 44}Sc-DOTATATE production can be reduced by target recovery. Due to low proton energy required to produce GBq activity level of {sup 44}Sc, the availability of {sup 44}Sc radioisotope could be enhanced to open new opportunities for applications in medical imaging. (orig.)

Preliminary analysis of radiologic consequence in accident cases with radiation sources in laboratories of the Physics Department of the IEN, cyclotrons and laboratories annexed

International Nuclear Information System (INIS)

Fajardo, P.W.; Silva, J.J.G. da.

1987-03-01

The requirements necessaries to the elaboration of the situation of Emergency PLans of the Nuclear Engineering Institute (IEN), Brazil, in particular, cases of radiation emergency are presented. An estimate of radiation in the laboratories of the Physic Department of the IEN, in case of accident, are given. The results presented are based in some hypothesis, values of radionuclide activity furnished by Radioisotopes Division and values of activities estimated by Radiation Protection Section of the IEN in function of datas achieved with cyclotron Division. The dose calculations are done to the cases of radionuclides inhalation and immersion of person in a semi-infinite cloud of contaminants. (V.R.B.)

Gas breakdown at cyclotron resonance with a submillimeter laser

International Nuclear Information System (INIS)

Hacker, M.P.; Temkin, R.J.; Lax, B.

1976-01-01

A pulsed 496-μm CH 3 F laser is used to produce gas breakdown in He at pressures between 1 and 300 Torr in an intense longitudinal magnetic field. Breakdown is detected by the observation of visible light when the electron cyclotron frequency (eB/m) equals the laser frequency, which occurs at B=216 kG for lambda=496 μm. At the lowest helium pressures and near cyclotron resonance, the focused laser intensity of 40 kW/cm 2 gives rise to very large electron heating rates, well beyond the limit of validity of conventional equilibrium breakdown theory. The observed result is an intensity-dependent resonant linewidth, much larger than predicted by equilibrium theories

Clinical application of iodine 123 with special consideration of radionuclide purity, measuring accuracy and radiation dose

International Nuclear Information System (INIS)

Hermann, H.J.; Ammon, J.; Winkel, K. zum; Haubold, U.

1975-01-01

Iodine 123 is a nearly 'ideal' radionuclide for thyroid imaging. The production of Iodine 123 requires cyclotrons or accelerators. The production of multicurie amounts of Iodine 123 has been suggested through the use of high-energy accelerators (> 60 MeV). Most of the methods for the production of Iodine 123 using a compact cyclotron result in contamination with f.e. Iodine 124 which reduces the spatial resolution of imaging procedures and increases the radiation dose to the patient. The radiation dose has been calculated for three methods of production. The various contamination with Iodine 124, Iodine 125 and Iodine 126 result in comparable radiation dose of Iodine 131, provided that the time between production and application is more than four half-live-times of Iodine 123. (orig.) [de

Focusing and bunching of ion beam in axial injection channel of IPHC cyclotron TR24

Science.gov (United States)

Adam, T.; Ivanenko, I.; Kazarinov, N.; Osswald, F.; Traykov, E.

2017-07-01

The CYRCe cyclotron (CYclotron pour la ReCherche et l’Enseignement) is used at IPHC (Institut Pluridisciplinaire Hubert Curien) for the production of radio-isotopes for diagnostics, medical treatments and fundamental research in radiobiology. The TR24 cyclotron produced and commercialized by ACSI (Canada) delivers a 16-25 MeV proton beam with intensity from few nA up to 500 μA. The solenoidal focusing instead of existing quadrupole one is proposed in this report. The changing of the focusing elements will give the better beam matching with the acceptance of the spiral inflector of the cyclotron. The parameters of the focusing solenoid are found. Additionally, the main parameters of the bunching system are evaluated in the presence of the beam space charge. This system consists of the buncher installed in the axial injection beam line of the cyclotron. The using of the grid-less multi harmonic buncher may increase the accelerated beam current and will give the opportunity to new proton beam applications.

Study of radionuclides created by 181Ta(γ,xn yp) reactions for bremsstrahlung photons produced by 150-MeV electrons

International Nuclear Information System (INIS)

Miller, M.A.; Dickens, J.K.

1991-12-01

Ten radionuclides, including isomers, from 172 Ta to 180 Ta and 180m Hf were produced by photon interactions with a sample of elemental tantalum and measured by counting photons using a high-resolution detection system. Relative yields of these radionuclides were obtained. In addition, precision half lives were obtained for 175,176,180 Ta and 180m Hf. Those obtained for the three Ta isotopes agree with previously reported values. For 180m Hf, the present measurements resulted in a half life determination of 6.05±0.06 hr, or about 10% longer than the currently adopted value for this half life

Production of radiopharmaceuticals by cyclotrons

International Nuclear Information System (INIS)

Schmitz, F.; Van Naemen, J.; Monclus, M.; Van Gansbeke, B.; Kadiata, M.; Ekelmans, D.; Moray, M.; Penninckx, R.; Goldman, S.

2004-01-01

Companies specialized in the development and installation of accelerator-based systems dedicated to the medical applications brought on the market cyclotrons well fitted to the requests of the industrial community or universities and so covering every segment of the market. These machines are fully automatic, and need reduced maintenance; they are highly specialized for defined tasks. They can produce high beam intensity and realize dual beam irradiation. Also the prices are reducing considerably. The targets and the automatic system follow the same trend. Unfortunately, the flexibility of these devices for new area of research and development has been dramatically reduced. The growing number of PET cameras has increased the popularity of PET tracers used for nuclear imaging. Consequently, there is a growing demand for these radiopharmaceuticals compounds labeled with short-lived radioisotopes for clinical applications. From a research and development tool in the eighties, PET has now grown up to a clinical tool. Moreover, depending of the social welfare, reimbursement of some PET examinations is granted, which accelerates the trend for an extended use of PET tracers. Regulatory affairs try to establish and standardize the control on these radiopharmaceutical compounds produced in a growing number of local radio pharmacies owning a baby cyclotron. On the other hand, the attention of equipment suppliers was brought in the setting up of a total quality control follow up. These efforts were successively achieved by getting for instance the ISO 9001 certificate

Studies of radioisotope production with an AVF cyclotron in TIARA

Energy Technology Data Exchange (ETDEWEB)

Sekine, Toshiaki [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

1997-03-01

The production of radioisotopes to be used mainly for nuclear medicine and biology is studied with an AVF cyclotron in TIARA. A production method of no-carrier-added {sup 186}Re with the {sup 186}W(p,n){sup 186}Re reaction has been developed; this product may be used as a therapeutic agent in radioimmunotherapy due to the adequate nuclear and chemical properties. For the study of the function of plants using a positron-emitter two-dimensional imaging system, a simple method of producing the positron emitter {sup 18}F in water was developed by taking advantage of a highly-energetic {alpha} beam from the AVF cyclotron. (author)

Radionuclide data

International Nuclear Information System (INIS)

Anon.

1992-01-01

Chapter 8 presents tables on selected alpha, beta, gamma and x-ray emitters by increasing energy; information on specific activity for selected radionuclides; naturally occurring radionuclides; the natural decay series; and the artificially produced neptunium series. A table of alpha emitters is listed by increasing atomic number and by energy. The table of β emitters presented is useful in identifying β emitters whose energies and possibly half-lives have been determined by standard laboratory techniques. It is also a handy guide to β-emitting isotopes for applications requiring specific half-lives and/or energies. Gamma rays for radionuclides of importance to radiological assessments and radiation protection are listed by increasing energy. The energies and branching ratios are important for radionuclide determinations with gamma spectrometry detectors. This section also presents a table of x-ray energies which are useful for radiochemical analyses. A number of nuclides emit x-rays as part of their decay scheme. These x-rays may be counted with Ar proportional counters, Ge planar or n-type Ge co-axial detectors, or thin crystal NaI(T1) scintillation counters. In both cases, spectral measurements can be made and both qualitative and quantitative information obtained on the sample. Nuclear decay data (energy and probability by radiation type) for more than one hundred radionuclides that are important to health physicists are presented in a schematic manner

Radionuclide Air Emissions Report for 2012

Energy Technology Data Exchange (ETDEWEB)

Wahl, Linnea [Ernest Orlando Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

2013-05-01

Berkeley Lab operates facilities where radionuclides are produced, handled, store d, and potentially emitted . These facilities are subject to the EPA radioactive air emission regulations in 40 CFR 61, Subpart H (EPA 1989a). Radionuclides may be emitted from stacks or vents on buildings where radionuclide production or use is authorized or they may be emitted as diffuse sources. In 2012, all Berkeley Lab sources were minor sources of radionuclides (sources resulting in a potential dose of less than 0.1 mrem/yr [0.001 mSv/yr]) . These minor sources include d about 140 stack sources and no diffuse sources . T here were no unplanned airborne radionuclide emissions from Berkeley Lab operations . Emissions from minor sources were measured by sampling or monitoring or were calculated based on quantities used, received for use, or produced during the year. Using measured and calculated emissions, and building- specific and common parameters, Laboratory personnel applied the EPA -approved computer code s, CAP88-PC and COMPLY , to calculate doses to the maximally exposed individual (MEI) at any offsite point where there is a residence, school, business, or office. Because radionuclides are used at three noncontiguous locations (the main site, Berkeley West Bio center, and Joint BioEnergy Institute), three different MEIs were identified.

Status and perspectives for the Pd-103 radioactive seeds production at the cyclotron IFIN-HH from Bucharest

International Nuclear Information System (INIS)

Dudu, D.; Popa, V.; Racolta, P.M.; Tetcu, N.; Voiculescu, Dana

2001-01-01

Historically, 103 Pb, a short-lived isotope for permanent implant treatment of early stage prostate cancer, was generated via the 102 Pd(n,γ) 103 Pd reaction which relied on the availability of 1% naturally abundant 102 Pd in an enriched form and its moderately high neutron capture cross section. For the last 12 years, the accelerator production method for 103 Pd has been based on the irradiation of the rhodium metal with rather low energy protons via the reaction 103 Rh(p,n) 103 Pd. Big corporations from USA operate more than 10 dedicated accelerators to produce this nuclide. The prostate cancer market with 180,000 new cases reported annually justifies the effort for this radionuclide production. Recently, a manufacture in Europe also brought the USA patented type of 103 Pd seed implants on the world market. Our interest for this radioisotope production was started in 2000, as a result of the demand of two big hospitals from Bucharest and the opportunity to participate in a research programme (333-F2-RC 832) co-ordinated by the IAEA in Vienna. The U-120 Cyclotron, made in 1956 and brought from Russia, was quite a reliable machine. The accelerator is a classical cyclotron with adjustable energy. Now at the level of our technology, we can maintain it by ourselves and operate it quite independently. The experiments for the first year were focused on obtaining homemade data on cross-section, thick target yields and possible contaminants for the nuclear reaction 103 Rh (p,n) 103 Pb in the proton energy region 5-14 MeV. The experiments were performed at our Van de Graaff HV Tandem FN 15 accelerator (8 MV on terminal) by using proton beams up to 14 MeV with a current intensity of 100 nA. Design and adaptation of a dedicated beam line at IFIN-HH Cyclotron for the 103 production was a priority in our work planning for the first year

Determination of neutron radiation source on components in the decy 13 cyclotron tank

International Nuclear Information System (INIS)

Sunardi; Silakhuddin

2015-01-01

In order to design the shielding on the Decy 13 cyclotron system, a study to identify the potency of neutron radiation at the cyclotron components in the vacuum tank has been carried out. The method used is to identify the kind of components material, analyzing significant nuclear reactions producing neutron, and determining the radial distribution of the formation probability of the nuclear reaction. The results of identification show that the nuclear reaction producing neutron are Cu 65 (p,n)Zn 65 , Cu 63 (p,n)Zn 63 and Fe 56 (p,n)Co 56 . The peaks of distribution curve of the formation probability of those reactions are located on the area between 37 cm and 39 cm. (author)

A study of a superconducting heavy ion cyclotron as a post accelerator for the CRNL MP Tandem

International Nuclear Information System (INIS)

Fraser, J.S.; Tunnicliffe, P.R.

1975-08-01

A novel design for a heavy ion cyclotron is described utilizing superconducting coils. Acting as a post accelerator for the CRNL MP Tandem accelerator, the proposed cyclotron is capable of producing an output energy of 10 MeV/u and intensities up to approximately 10 10 particles/s for uranium. (E.C.B.)

Examination of tracer method using 43K produced with a cyclotron

International Nuclear Information System (INIS)

Yuida, Koichi; Kawarazaki, Yuji; Shibuya, Masao; Nozaki, Tadashi.

1980-01-01

The 43 K tracer produced with a cyclotron is contaminated with about the same amount of 42 K. During first 43 hours after the production, the rate of attenuation of its radioactivity was greater than the theoretical value of 43 K (half-life 22.4 hours) because of the rapid attenuation of radioactivity of the contaminating 42 K (half-life 12.4 hours). After that, however, the rate of attenuation in the radioactivity of 43 K tracer followed the attenuation curve of 22.4 hr half-life, i.e., the radioactivity of the contaminating 42 K was negligible. The potassium chloride fertilizer labelled with 43 K-tracer (or 42 K-tracer) was applied for 8 days (or 4.5 days in case of 42 K) to 2-month-old rice plants grown by hydroponics, and for 7 days to rice plants grown on soil (at ripening stage). The rice plants were then dried for 24 hours at 70 deg C, and the radioactivity was measured by a scintillation counter. 43 K was able to be traced for 13.3 days in the plants grown by hydroponics, and 42 K for 5.4 days, but 43 K was able to be traced only for 7.4 days in the plants grown on soil which absorb 43 K poorly. Since 43 K and 42 K are γ-ray emittors, and the energy is not low, microautoradiograms were not able to be made, but macroautoradiograms were made. The autoradiograms for 43 K and 42 K did not differ in resolution, and both were clear. The radioactivity of 43 K did not diminish so rapidly as 42 K, but was lost in one month. Such character of 43 K is beneficial both for tracer experiments and for the prevention of environmental pollution. (Kaihara, S.)

Short-lived cyclotron produced radionuclides evaluation on the myocardial imaging agents

International Nuclear Information System (INIS)

Rikitake, Tomoyuki; Tateno, Yukio; Yamane, Akiko; Matsumoto, Touru; Umegaki, Youichiro

1978-01-01

Organ uptake after venous administration of 13 N-ammonia, 43 K, 86 Rb, 201 Tl and after rectal administration of 13 N-ammonia was studied. Each nuclides highly accumulated in myocardium after intravenous injection, but rectal administrated 13 N-ammonia did not show this tendency. Intravenously injected 13 N-ammonia showed very early myocardial uptake and early secretion from kidney. Rectal administrated 13 N-ammonia was less accumulated in myocardium. 43 KCl and 13 NH 4 Cl were injected intravenously and administrated from the rectum to the rabbits under imaging scintilator system. Whole-body scintiscanner with display-processing unit was used for a 43 KCl injected rabbit. A positroncamera with computer system (TOSBAC 3400 on line system) was used for 13 NH 4 Cl (i.v. and rectal ad.) rabbits. The dynamic studies of 43 KCl, 13 NH 4 Cl were made from these imaging data. The countratio of heart to the liver after 43 K injection was nearly equal or less than the liver. The peakcount was at 15 min after 13 NH 4 Cl intravenous injection. 13 N accumulated promptly at upper mediastinal part and kidney, and soon disappeared from these part. Uptake of the heat was high and that of the liver was low. When 13 NH 4 Cl was administrated from the rectum, 13 N trapped at the liver, and uptake of the heart was very low level. Scintiscanning after 13 KCl intravenously injected, did not show the high resolution. Rabbit heart was distinguishable from the liver, but there are no visibility of the detail. Seeing positronscintigram after 13 NH 4 Cl administration both from intravenously and from rectum, the detail was well visible. We concluded the positron scintigram after 13 NH 4 Cl injection should be a good myocardial imaging agent. Furthermore, 13 Nh 4 Cl has two eminent characters as a myocardial imaging agent comparing 201 TlCl. One is prompt making of image, the others is the very low radiation dose. (auth.)

A line-of-sight electron cyclotron emission receiver for electron cyclotron resonance heating feedback control of tearing modes

DEFF Research Database (Denmark)

Oosterbeek, J.W.; Bürger, A.; Westerhof, E.

2008-01-01

An electron cyclotron emission (ECE) receiver inside the electron cyclotron resonance heating (ECRH) transmission line has been brought into operation. The ECE is extracted by placing a quartz plate acting as a Fabry-Perot interferometer under an angle inside the electron cyclotron wave (ECW) bea...

Evaluation of the production capabilities of 18F, 11C, 13N and 15O PET isotopes at the PET-cyclotron-radiochemistry site of Messina University

Directory of Open Access Journals (Sweden)

Lucrezia Auditore

2017-02-01

Full Text Available The production of 18F, 11C, 13N, and 15O positron emitting radionuclides for PET imaging is usually accomplished in Nuclear Medicine Departments through direct nuclear reactions induced by protons accelerated by compact medical cyclotrons on liquid or gaseous targets. Messina University has funded the construction of a PET-cyclotron-radio-chemistry plant at the Messina University Hospital, equipped with a 11 MeV self-shielded cyclotron. We estimated the expected production yields of these nuclides, accounting for target thickness, production of other radioactive nuclides, and time effects on the irradiated target purity. To this aim, both TALYS code (v. 1.8 and an analytical approach based on EXFOR experimental data were used. The general agreement between the two approaches, and with the available literature data, allows to assess the expected yields at the End of Bombardment, and relative target purities, to be used for further radiopharmaceutical preparation steps.

Commercial compact cyclotrons in the 90's

International Nuclear Information System (INIS)

Milton, B.F.

1995-09-01

Cyclotrons continue to be efficient accelerators for radio-isotope production. In recent years, developments in the accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicate a strong future for commercial cyclotrons. In this paper we will survey recent developments in the areas of cyclotron technology, as they relate to the new generation of commercial cyclotrons. Design criteria for the different types of commercial cyclotrons will be presented, with reference to those demands that differ from those in a research oriented cyclotron project. We will also discuss the possibility of systems designed for higher energies and capable of extracted beam currents of up to 2.0 mA. (author)

Commercial compact cyclotrons in the 90's

International Nuclear Information System (INIS)

Milton, B.F.

1995-09-01

Cyclotrons continue to be efficient accelerators for radio-isotope production. In recent years, developments in the accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicate a strong future for commercial cyclotrons. In this paper the authors will survey recent developments in the areas of cyclotron technology, as they relate to the new generation of commercial cyclotrons. Design criteria for the different types of commercial cyclotrons will be presented, with reference to those demands that differ from those in a research oriented cyclotron project. The authors also discuss the possibility of systems designed for higher energies and capable of extracted beam currents of up to 2.0 mA

Naturally occurring radionuclides in agricultural products: An overview

International Nuclear Information System (INIS)

Hanlon, E.A.

1994-01-01

Low levels of naturally occurring radionuclides exist in phosphatic clays, a by-product of phosphatic mining and beneficiation processes. Concerns about these radionuclides entering the human food chain were an immediate research priority before the phosphate clays could be reclaimed for intensive agricultural purposes. Efforts included the assembly of a large body of data from both sons and plants, part of which were produced by the Polk County (Florida) Mined Lands Agricultural Research/Demonstration Project MLAR/DP. Additional detailed studies involving dairy and beef cattle (Bos taurus) were conducted by researchers working with the MLAR/DP. A national symposium was conducted in which data concerning the MLAR/DP work and other research projects also dealing with naturally occurring radionuclides in agriculture could be discussed. The symposium included invited review papers dealing with the identification of radionuclide geological origins, the geochemistry and movement of radionuclides within the environment, mechanisms of plant uptake, entry points into the food chain, and evaluation of dose and risk assessment to the consumer of low levels of radionuclides. The risk to human health of an individual obtaining 0.1 of his or her dietary intake from crops produced on phosphatic clays increased by 1 in 5 x 10 6 /yr above a control individual consuming no food grown on phosphatic clays. Leaf tissues were found to be generally higher than fruit, grain, or root tissues. The natural range in radionuclide content among various food types was greater than the difference in radionuclides content between the same food produced on phosphatic clays vs. natural soils. 19 refs

Cost benefit analysis of the radiological shielding of medical cyclotrons using a genetic algorithm

International Nuclear Information System (INIS)

Mukherjee, Bhaskar

2001-01-01

Adequate radiation shielding is vital to the safe operation of modern commercial medical cyclotrons producing large yields of short-lived radioisotopes. The radiological shielding constitutes a significant capital investment for any new cyclotron-based radioisotope production facility; hence, the shielding design requires an accurate cost-benefit analysis often based on a complex multi-variant optimization technique. This paper demonstrates the application of a Genetic Algorithm (GA) for the optimum design of the high yield target cave of a Medical Cyclotron radioisotope production facility based in Sydney, Australia. The GA is a novel optimization technique that mimics the Darwinian Evolution paradigm and is ideally suited to search for global optima in a large multi-dimensional solution space

Electron cyclotron current drive efficiency in an axisymmetric tokamak

Energy Technology Data Exchange (ETDEWEB)

Gutierrez-Tapia, C.; Beltran-Plata, M. [Instituto Nacional de Investigaciones Nucleares, Dept. de Fisica, Mexico D.F. (Mexico)

2004-07-01

The neoclassical transport theory is applied to calculate electron cyclotron current drive (ECCD) efficiency in an axisymmetric tokamak in the low-collisionality regime. The tokamak ordering is used to obtain a system of equations that describe the dynamics of the plasma where the nonlinear ponderomotive (PM) force due to high-power radio-frequency (RF) waves is included. The PM force is produced around an electron cyclotron resonant surface at a specific poloidal location. The ECCD efficiency is analyzed in the cases of first and second harmonics (for different impinging angles of the RF waves) and it is validated using experimental parameter values from TCV and T-10 tokamaks. The results are in agreement with those obtained by means of Green's function techniques. (authors)

Inorganic ion-exchangers. Their role in chromatographic radionuclide generators for the decade 1993-2002

International Nuclear Information System (INIS)

Mushtaq, A.

2004-01-01

Ion-exchangers are found not only in water purification processes, the original major application, but also in analytical chemistry for the separation and isolation of elements, hydrometallurgy, inorganic chemistry and biochemistry, in food technology, and of course in many specialized fields related to the utilization of atomic energy. The use of organic ion-exchangers is limited by virtue of their limited stability under harsh conditions, whereas inorganic ion-exchangers possess important properties, which make them very useful for chemical separation and purification in intense radiation fields. The availability of short-lived radionuclides from radionuclide generators provides an inexpensive and convenient alternative to in-house radioisotope production facilities such as accelerators and cyclotrons. Due to their simplicity of operation, chromatographic based generators have been the method of choice, although generators based on solvent extraction and on volatilization and sublimation have also been developed, and are routinely used. In this paper use of inorganic ion-exchangers for the development of radionuclide generators for the decade 1993-2002 has been compiled. (author)

Ion-cyclotron-resonance- and Fourier-transform-ion-cyclotron-resonance spectroscopy: technology and application

International Nuclear Information System (INIS)

Luederwald, I.

1977-01-01

Instrumentation and technology of Ion-Cyclotron-Resonance and Fourier-Transform-Ion-Cyclotron-Resonance Spectroscopy are described. The method can be applied to studies of ion/molecule reactions in gas phase, to obtain thermodynamic data as gas phase acidity or basicity, proton and electron affinity, and to establish reaction mechanisms and ion structures. (orig.) [de

Electron cyclotron heating (ECH) of tokamak plasmas

International Nuclear Information System (INIS)

Hoshino, Katsumichi

1990-01-01

Electron cyclotron heating (ECH) is one of the intense methods of plasma heating, and which utilizes the collisionless electron-cyclotron-resonance-interaction between the launched electromagnetic waves (called electron cyclotron waves) and electrons which are one of the constituents of the high temperature plasmas. Another constituent, namely the ions which are subject to nuclear fusion, are heated indirectly but strongly and instantly (in about 0.1 s) by the collisions with the ECH-heated electrons in the fusion plasmas. The recent progress on the development of high-power and high-frequency millimeter-wave-source enabled the ECH experiments in the middle size tokamaks such as JFT-2M (Japan), Doublet III (USA), T-10 (USSR) etc., and ECH has been demonstrated to be the sure and intense plasma heating method. The ECH attracts much attention for its remarkable capabilities; to produce plasmas (pre-ionization), to heat plasmas, to drive plasma current for the plasma confinement, and recently especially by the localization and the spatial controllability of its heating zone, which is beneficial for the fine controls of the profiles of plasma parameters (temperature, current density etc.), for the control of the magnetohydrodynamic instabilities, or for the optimization/improvement of the plasma confinement characteristics. Here, the present status of the ECH studies on tokamak plasmas are reviewed. (author)

Developments in radioisotope production and labelling of radiopharmaceuticals

International Nuclear Information System (INIS)

Lambrecht, R.M.

1998-01-01

Recent developments in both reactor and accelerator production of radioisotopes finding applications in nuclear medicine and in biomedical research are summarised. The priorities for the production of 48 different cyclotron radioisotopes; and for 42 reactor produced radioisotopes finding biomedical applications are identified. Each includes 5 generator systems. The rapid expansion of cyclotron based radioisotope production and automated synthesis of short-lived radiopharmaceuticals with the position-emitting radionuclides continues to gain momentum. Recent feasibility studies of the cyclotron production of 186 Re, 99m Tc and of 99 Mo are cited as examples of motivation to develop accelerator alternatives to use of nuclear reactors for medical radioisotope production. Examples of SPET and PET radiopharmaceuticals labelled with 131 I, 123 I, 124 I, 18 F, and with therapeutic radionuclides are highlighted. (author)

20 years Rossendorf cyclotron

International Nuclear Information System (INIS)

1978-08-01

On the occasion of the 20th anniversary of initiating of the Rossendorf cyclotron accounts are given of most important works and results in the field of accelerator engineering and utilization of this machine. The reports show the trend of development and actual spectrum of application. The enclosed literature lists give a survey of technical and experimental works at cyclotron. (author)

Radionuclide injury to the lung

International Nuclear Information System (INIS)

Dagle, G.E.; Sanders, C.L.

1984-01-01

Radionuclide injury to the lung has been studied in rats, hamsters, dogs, mice and baboons. Exposure of the lung to high dose levels of radionuclides produces a spectrum of progressively more severe functional and morphological changes, ranging from radiation pneumonitis and fibrosis to lung tumors. These changes are somewhat similar for different species. Their severity can be related to the absorbed radiation dose (measured in rads) produced by alpha, beta or gamma radiation emanating from various deposited radionuclides. The chemicophysical forms of radionuclides and spatial-temporal factors are also important variables. As with other forms of injury to the lung, repair attempts are highlighted by fibrosis and proliferation of pulmonary epithelium. Lung tumors are the principal late effect observed in experimental animals following pulmonary deposition of radionuclides at dose levels that do not result in early deaths from radiation pneumonitis or fibrosis. The predominant lung tumors described have been of epithelial origin and have been classified, in decreasing frequency of occurrence, as adenocarcinoma, bronchioloalveolar carcinoma, epidermoid carcinomas and combined epidermoid and adenocarcinoma. Mesothelioma and fibrosarcoma have been observed in rats, but less commonly in other species. Hemangiosarcomas were frequently observed in dogs exposed to beta-gamma emitters, and occasionally in rats exposed to alpha emitters. These morphologic changes in the lungs of experimental animals were reviewed and issues relevant to the prediction of human hazards discussed. 88 references

Electroplating targets for production of unique PET radionuclides

International Nuclear Information System (INIS)

Bui, V.; Sheh, Y.; Finn, R.

1994-01-01

The past decade has witnessed the applications of Positron Emission Tomography (PET) evolving from a purely research endeavour to a procedure which has specific clinical applications in the areas of cardiology, neurology and oncology. The growth of PET has been facilitated by developments in medical instrumentation and radiopharmaceutical chemistry efforts. Included in this latter effort has been the low energy accelerator production and processing of unique PET radionuclides appropriate for the radiolabeling of biomolecules i.e. monoclonal antibodies and pepetides. The development and application of electroplated targets of antimony and copper for the production of iodine-124 and gallium-66 respectively, utilizing the Memorial Sloan-Kettering Cancer Center cyclotron are examples of target design and development applicable to many medical accelerators

Radioactivity measurement of 18F in 16 ml vials for calibration of radionuclide calibrators

International Nuclear Information System (INIS)

Wurdiyanto, Gatot; Marsoem, Pujadi; Candra, Hermawan; Wijono, Paidi

2012-01-01

Fluorine-18 is obtained through the reaction 18 O(p, n) 18 F using a cyclotron that is situated in a hospital in Jakarta. Standardization of the 18 F solution is performed by gamma spectrometry using calibration sources of 152 Eu, 60 Co and 137 Cs that have traceability to the International System of units (SI). The activities in the 16 ml vials that were used for calibrating the radionuclide calibrators were between 1 and 2 GBq, with expanded uncertainties of 3.8%. The expanded uncertainty, at a coverage factor of k=2, on the derived calibration factor for the radionuclide calibrator was 6.6%. - Highlights: ► PTKMR–BATAN as a NMI of Indonesia is required to have procedures to calibrate the radionuclide calibrators. ► Standardizations were carried out on a solution of [ 18 F]FDG using gamma spectrometry. ► The volume of 18 F solutions used was 16 ml because this is the volume often used in hospitals. ► The Secondary Standard ionization chamber is a CRC-7BT Capintec radionuclide calibrator. ► A dial setting for 16 ml of [ 18 F]FDG solution in a vial is 443 for the Capintec dose calibrator.

Environmental impact assessment for the apparatus of positron emission tomograph and cyclotron

International Nuclear Information System (INIS)

Yu Shui; Gu Hongkun; Wu Songhuan; Zhang Wenying; Zhao Fa; Wang Gongpeng

2000-01-01

Cyclotron, type RDS 111, produced by CTI incorporation, was used as an example. According to the characteristic of the radiation source term, the environmental impacts of the apparatus working in normal and abnormal conditions were assessed

Application of superconductivity in cyclotron construction

International Nuclear Information System (INIS)

Blosser, H.G.

1982-01-01

This paper reviews major concepts and design features of the new class of cyclotrons which use superconducting coils to provide main magnet excitation. The discussion begins with a brief historical review tracing the evolution of these ''superconducting'' cyclotrons and the impact of this application of superconductivity in pushing back traditional cyclotron construction limits. This is followed by a review of the principal phenomena which come into play to set new limits on the operating regime, and the nature of these limits, some of which arise from orbit properties and some of which result from construction intricacies in the coil and in the rf system. Conclusions anticipate a future widely encompassing role in the application of superconductivity to cyclotron

Neutron spectra due 13N production in a PET cyclotron

International Nuclear Information System (INIS)

Benavente, J.A.; Vega-Carrillo, H.R.; Lacerda, M.A.S.; Fonseca, T.C.F.; Faria, F.P.; Silva, T.A. da

2015-01-01

Monte Carlo and experimental methods have been used to characterize the neutron radiation field around PET (Positron Emission Tomography) cyclotrons. In this work, the Monte Carlo code MCNPX was used to estimate the neutron spectra, the neutron fluence rates and the ambient dose equivalent (H*(10)) in seven locations around a PET cyclotron during 13 N production. In order to validate these calculations, H*(10) was measured in three sites and were compared with the calculated doses. All the spectra have two peaks, one above 0.1 MeV due to the evaporation neutrons and another in the thermal region due to the room-return effects. Despite the relatively large difference between the measured and calculated H*(10) for one point, the agreement was considered good, compared with that obtained for 18 F production in a previous work. - Highlights: • MCNPX code was used to estimate the neutron spectra in a PET cyclotron. • Neutrons were estimated when 13 N is produced. • Neutron spectra show evaporation and room-return neutrons. • Calculated H*(10) were compared with measured H*(10)

Investigation of bio-oil produced by hydrothermal liquefaction of food waste using ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry.

Science.gov (United States)

Kostyukevich, Yury; Vlaskin, Mikhail; Borisova, Ludmila; Zherebker, Alexander; Perminova, Irina; Kononikhin, Alexey; Popov, Igor; Nikolaev, Eugene

2018-02-01

Recent research has revealed that more than 1.3 billion tons of food is wasted globally every year. The disposal of such huge biomass has become a challenge. In the present paper, we report the production of the bio-oil by hydrothermal liquefaction of three classes of food waste: meat, cheese and fruits. The highest yield of the bio-oil was observed for meat (∼60%) and cheese (∼75%), while for fruits, it was considerably low (∼10%). The molecular composition of the obtained bio-oil was investigated using ultrahigh resolution Fourier Transform Ion Cyclotron Resonance mass spectrometry and was found to be similar to that obtained from algae. Several thousand heteroatom compounds (N, N 2 , ON 2 , etc. classes) were reliably identified from each sample. It was found that bio-oils produced from meat and cheese have many compounds (∼90%) with common molecular formulas, while bio-oil produced from fruits differs considerably (∼30% of compounds are unique).

40 CFR 141.66 - Maximum contaminant levels for radionuclides.

Science.gov (United States)

2010-07-01

... beta particle and photon radioactivity from man-made radionuclides in drinking water must not produce.../year). (2) Except for the radionuclides listed in table A, the concentration of man-made radionuclides... may make this technology too complex for small surface water systems. e Removal efficiencies can vary...

How cyclotrons work

International Nuclear Information System (INIS)

Nolan, D.

1992-01-01

The operating principles of a cyclic accelerator are presented based on the IBA Cyclone 30 negative ion cyclotron, selected for the Australia's first medical cyclotron. Its main features are: acceleration with variable energy of between 15-30 million electron volts, the capability of extracting two beams simultaneously, low power consumption, easy maintenance. Other aspects not directly related to the principle of operation discussed include the vacuum and the radio-frequency systems as well as the complex computerized control system used to automatically control start-up and shut-down operations. ills

Development of positron emitting radionuclides for imaging with improved positron detectors

International Nuclear Information System (INIS)

Yano, Y.

1976-10-01

Recent advances in positron cameras and positron ring detectors for transverse section reconstruction have created renewed interest in positron emitting radionuclides. This paper reports on: generator-produced 82 Rb; cyclotron-produced 62 Zn; and reactor-produced 64 Cu. Investigation of the 82 Sr (25 d)-- 82 Rb (75 s) generator determined the elution characteristics for Bio-Rex 70, a weakly acidic carboxylic cation exchanger, using 2% NaCl as the eluent. The yield of 82 Rb and the breakthrough of 82 Sr were determined for newly prepared columns and for long term elution conditions. Spallation-produced 82 Sr was used to charge a compact 82 Rb generator to obtain multi-millicurie amounts of 82 Rb for myocardial imaging. Zinc accumulates in the islet cells of the pancreas and in the prostate. Zinc-62 was produced by protons on Cu foil and separated by column chromatography. Zinc-62 was administered as the amino acid chelates and as the ZnCl 2 to tumor and normal animals. Tissue distribution was determined for various times after intravenous injection. Pancreas-liver images of 62 Zn-histidine uptake were obtained in animals with the gamma camera and the liver uptake of /sup 99m/Tc sulfur colloid was computer subtracted to image the pancreas alone. The positron camera imaged uptake of 62 Zn-histidine in the prostate of a dog at 20 h. 64 Cu was chelated to asparagine, a requirement of leukemic cells, and administered to lymphoma mice. Uptake in tumor and various tissues was determined and compared with the uptake of 67 Ga citrate under the same conditions. 64 Cu-asparagine had better tumor-to-soft tissue ratios than 67 Ga-citrate

A new cyclotron for biomedical research

International Nuclear Information System (INIS)

Wolber, G.

1988-01-01

This paper presents the rationale for replacing the old AEG Compact Cyclotron (built in 1969/71) of the Institute for Radiology and Pathophysiology at the German Cancer Research Center by a 30 MeV H - /15 MeV D - cyclotron. A status report is followed by the scientific and technical reasoning as well as budgetary and organizational considerations. In the appendix we tried to explain the function of a cyclotron in a simple and comprehensive manner. (orig.) [de

Cyclotron Phase-Coherent Ion Spatial Dispersion in a Non-Quadratic Trapping Potential is Responsible for FT-ICR MS at the Cyclotron Frequency

Science.gov (United States)

Nagornov, Konstantin O.; Kozhinov, Anton N.; Tsybin, Yury O.

2018-01-01

Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) at the cyclotron frequency instead of the reduced cyclotron frequency has been experimentally demonstrated using narrow aperture detection electrode (NADEL) ICR cells. Here, based on the results of SIMION simulations, we provide the initial mechanistic insights into the cyclotron frequency regime generation in FT-ICR MS. The reason for cyclotron frequency regime is found to be a new type of a collective motion of ions with a certain dispersion in the initial characteristics, such as pre-excitation ion velocities, in a highly non-quadratic trapping potential as realized in NADEL ICR cells. During ion detection, ions of the same m/z move in phase for cyclotron ion motion but out of phase for magnetron (drift) ion motion destroying signals at the fundamental and high order harmonics that comprise reduced cyclotron frequency components. After an initial magnetron motion period, ion clouds distribute into a novel type of structures - ion slabs, elliptical cylinders, or star-like structures. These structures rotate at the Larmor (half-cyclotron) frequency on a plane orthogonal to the magnetic field, inducing signals at the true cyclotron frequency on each of the narrow aperture detection electrodes. To eliminate the reduced cyclotron frequency peak upon dipolar ion detection, a number of slabs or elliptical cylinders organizing a star-like configuration are formed. In a NADEL ICR cell with quadrupolar ion detection, a single slab or an elliptical cylinder is sufficient to minimize the intensity of the reduced cyclotron frequency components, particularly the second harmonic. [Figure not available: see fulltext.

Process for encapsulating radionuclides

International Nuclear Information System (INIS)

Brownell, L.E.; Isaacson, R.E.

1976-01-01

Radionuclides are immobilized in virtually an insoluble form by reacting at a temperature of at least 90 0 C as an aqueous alkaline mixture having a solution pH of at least 10, containing a source of silicon, the radionuclide waste, and a metal cation. The molar ratio of silicon to the metal cation is on the order of unity to produce a gel from which complex metalosilicates crystallize to entrap the radionuclides within the resultant condensed crystal lattice. The product is a silicious stone-like material which is virtually insoluble and nonleachable in alkaline or neutral environment. One embodiment provides for the formation of the complex metalo-silicates, such as synthetic pollucite, by gel formation with subsequent calcination to the solid product; another embodiment utilizes a hydrothermal process, either above ground or deep within basalt caverns, at greater than atmospheric pressures and a temperature between 90 and 500 0 C to form complex metalo-silicates, such as strontium aluminosilicate. Another embodiment provides for the formation of complex metalo-silicates, such as synthetic pollucite, by slurrying an alkaline mixture of bentonite or kaolinite with a source of silicon and the radionuclide waste in salt form. In each of the embodiments a mobile system is achieved whereby the metalo-silicate constituents reorient into a condensed crystal lattice forming a cage structure with the condensed metalo-silicate lattice which completely surrounds the radionuclide and traps the radionuclide therein; thus rendering the radionuclide virtually insoluble

Permanent magnet electron cyclotron resonance plasma source with remote window

International Nuclear Information System (INIS)

Berry, L.A.; Gorbatkin, S.M.

1995-01-01

An electron cyclotron resonance (ECR) plasma has been used in conjunction with a solid metal sputter target for Cu deposition over 200 mm diameters. The goal is to develop a deposition system and process suitable for filling submicron, high-aspect ratio ULSI features. The system uses a permanent magnet for creation of the magnetic field necessary for ECR, and is significantly more compact than systems equipped with electromagnets. A custom launcher design allows remote microwave injection with the microwave entrance window shielded from the copper flux. When microwaves are introduced at an angle with respect to the plasma, high electron densities can be produced with a plasma frequency significantly greater than the electron cyclotron frequency. Copper deposition rates of 1000 A/min have been achieved

Radionuclide daughter inventory generator code: DIG

International Nuclear Information System (INIS)

Fields, D.E.; Sharp, R.D.

1985-09-01

The Daughter Inventory Generator (DIG) code accepts a tabulation of radionuclide initially present in a waste stream, specified as amounts present either by mass or by activity, and produces a tabulation of radionuclides present after a user-specified elapsed time. This resultant radionuclide inventory characterizes wastes that have undergone daughter ingrowth during subsequent processes, such as leaching and transport, and includes daughter radionuclides that should be considered in these subsequent processes or for inclusion in a pollutant source term. Output of the DIG code also summarizes radionuclide decay constants. The DIG code was developed specifically to assist the user of the PRESTO-II methodology and code in preparing data sets and accounting for possible daughter ingrowth in wastes buried in shallow-land disposal areas. The DIG code is also useful in preparing data sets for the PRESTO-EPA code. Daughter ingrowth in buried radionuclides and in radionuclides that have been leached from the wastes and are undergoing hydrologic transport are considered, and the quantities of daughter radionuclide are calculated. Radionuclide decay constants generated by DIG and included in the DIG output are required in the PRESTO-II code input data set. The DIG accesses some subroutines written for use with the CRRIS system and accesses files containing radionuclide data compiled by D.C. Kocher. 11 refs

Evaluation of {sup 18}F radioactive concentration in exhaust at cyclotron facility at Chosun University

Energy Technology Data Exchange (ETDEWEB)

Jeong, Cheol Ki; Jang, Han; Lee, Goung Jin [Dept. of Nuclear Engineering, Chsoun University, Gwangju (Korea, Republic of)

2016-11-15

the recent prevalence of PET examinations in Korea has led to an increase in the number of cyclotrons. the medical isotope 18F produced in most cyclotron facilities currently operating in Korea is emitted into the environment during the production of [{sup 18}F]FdG, a cancerdiagnosis reagent. the amount of [{sup 18}F]FdG synthesized determines the radioactive concentration of {sup 18}F in the exhaust. at some facilities, this amount temporarily exceeds the emission limit. In this study, we evaluated the {sup 18}F radioactivity concentration in the exhaust from the cyclotron facility at chosun university. the {sup 18}F radioactivity concentration was measured using an air sampler and a hPGe semiconductor detector. the measurements showed that the radioactive concentration of {sup 18}F in the exhaust at the cyclotron facility at Chosun university was the highest during [{sup 18}F]FdG synthesis but remained under the legal limit of 2,000 Bq m{sup -3}.

A new RF system for a rejuvenated Synchro-cyclotron

CERN Multimedia

1975-01-01

The Synchro-cyclotron is shown here shortly after the completion of the improvement programme, which left the steel magnet yoke as almost the only remaining component of the original machine. On the left can be seen the rotary condenser which produces the frequency modulation required for the acceleration (one of a pair available -in this instance ROTCO II). (see photo 7506015)

Cyclotron method for heavy ion acceleration

International Nuclear Information System (INIS)

Gikal, B.N.; Gul'bekyan, G.G.; Kutner, V.B.; Oganesyan, R.Ts.

1984-01-01

Studies on heavy ion beams in a wide range of masses (up to uranium) and energies disclose essential potential opportunities for solution of both fundamental scientific and significant economical problems. A cyclotron method for heavy ion acceleration is considered. Development of low and medium energy heavy ion accelerators is revealed. The design of a complex comprising two isochronous cyclotrons which is planned to be constrdcted 1n the JINR is described. The cyclotron complex includes the U-400 and the U-400 M cyclotrons and it is intended for acceleration of both 35-20 MeV/nucleon superheavy ions such as Xe-U and 120 MeV/nucleon light ions. Certain systems of the accelerators are described. Prospects of the U-400 and the U-400 M development are displayed

Radiopharmaceuticals and other compounds labelled with short-lived radionuclides

CERN Document Server

Welch, Michael J

2013-01-01

Radiopharmaceuticals and Other Compounds Labelled with Short-Lived Radionuclides covers through both review and contributed articles the potential applications and developments in labeling with short-lived radionuclides whose use is restricted to institutions with accelerators. The book discusses the current and potential use of generator-produced radionuclides as well as other short-lived radionuclides, and the problems of quality control of such labeled compounds. The book is useful to nuclear medicine physicians.

Commercial cyclotrons. Part I: Commercial cyclotrons in the energy range 10 30 MeV for isotope production

Science.gov (United States)

Papash, A. I.; Alenitsky, Yu. G.

2008-07-01

A survey of commercial cyclotrons for production of medical and industrial isotopes is presented. Compact isochronous cyclotrons which accelerate negative hydrogen ions in the energy range 10 30 MeV have been widely used over the last 25 years for production of medical isotopes and other applications. Different cyclotron models for the energy range 10 12 MeV with moderate beam intensity are used for production of 11C, 13N, 15O, and 18F isotopes widely applied in positron emission tomography. Commercial cyclotrons with high beam intensity are available on the market for production of most medical and industrial isotopes. In this work, the physical and technical parameters of different models are compared. Possibilities of improving performance and increasing intensity of H- beams up to 2 3 mA are discussed.

Solid targetry for compact cyclotrons

International Nuclear Information System (INIS)

Comor, J.

2004-01-01

In this presentation authors present experimental results of solid targetry for compact cyclotrons. It is concluded: Solid targetry is not restricted to large accelerator centers anymore; Small and medium scale radioisotope production is feasible with compact cyclotrons; The availability of versatile solid target systems is expected to boost the radiochemistry of 'exotic' positron emitters

Research and development of ion surfing RF carpets for the cyclotron gas stopper at the NSCL

Energy Technology Data Exchange (ETDEWEB)

Gehring, A.E. [Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87544 (United States); Brodeur, M. [University of Notre Dame, Notre Dame, IN (United States); Bollen, G.; Morrissey, D.J.; Schwarz, S. [National Superconducting Cyclotron Laboratory, Michigan State University, 640 S. Shaw Lane, East Lansing, MI 48824 (United States)

2016-06-01

A model device to transport thermal ions in the cyclotron gas stopper, a next-generation beam thermalization device under construction at the National Superconducting Cyclotron Laboratory, is presented. Radioactive ions produced by projectile fragmentation will come to rest at distances as large as 45 cm from the extraction orifice of the cyclotron gas stopper. The thermalized ions will be transported to the exit by RF carpets employing the recently developed “ion surfing” method. A quarter-circle prototype RF carpet was tested with potassium ions, and ion transport velocities as high as 60 m/s were observed over distances greater than 10 cm at a helium buffer gas pressure of 80 mbar. The transport of rubidium ions from an RF carpet to an electrode below was also demonstrated. The results of this study formed the basis of the design of the RF carpets for use in the cyclotron gas stopper.

Ponderomotive force near cyclotron resonance

Energy Technology Data Exchange (ETDEWEB)

Kono, Mitsuo; Sanuki, Heiji

1987-01-01

The ponderomotive force, which is involved in the excitation of macroscopic behaviors of plasma caused by wave motion, plays an important role in various non-linear wave motion phenomena. In the present study, equations for the pondermotive force for plasma in a uniform magnetic field is derived using a renormalization theory which is based on the Vlasov equation. It is shown that the pondermotive force, which diverges at the cyclotron resonence point according to adiabatic approximation, can be expressed by a non-divergent equation by taking into account the instability of the cyclotron orbit due to high-order scattering caused by a wave. This is related with chaotic particle behaviors near cyclotron resonance, where the pondermotive force is small and the diffusion process prevails. It is assumed here that the amplitude of the high-frequency electric field is not large and that the broadening of cyclotron levels is smaller than the distance between the levels. A global chaos will be created if the amplitude of the electric field becomes greater to allow the broadening to exceed the distance between the levels. (Nogami, K.).

Cyclotron transitions of bound ions

Science.gov (United States)

Bezchastnov, Victor G.; Pavlov, George G.

2017-06-01

A charged particle in a magnetic field possesses discrete energy levels associated with particle rotation around the field lines. The radiative transitions between these levels are the well-known cyclotron transitions. We show that a bound complex of particles with a nonzero net charge displays analogous transitions between the states of confined motion of the entire complex in the field. The latter bound-ion cyclotron transitions are affected by a coupling between the collective and internal motions of the complex and, as a result, differ from the transitions of a "reference" bare ion with the same mass and charge. We analyze the cyclotron transitions for complex ions by including the coupling within a rigorous quantum approach. Particular attention is paid to comparison of the transition energies and oscillator strengths to those of the bare ion. Selection rules based on integrals of collective motion are derived for the bound-ion cyclotron transitions analytically, and the perturbation and coupled-channel approaches are developed to study the transitions quantitatively. Representative examples are considered and discussed for positive and negative atomic and cluster ions.

arXiv Cyclotrons: Magnetic Design and Beam Dynamics

CERN Document Server

Zaremba, Simon

Classical, isochronous, and synchro-cyclotrons are introduced. Transverse and longitudinal beam dynamics in these accelerators are covered. The problem of vertical focusing and iscochronism in compact isochronous cyclotrons is treated in some detail. Different methods for isochronization of the cyclotron magnetic field are discussed. The limits of the classical cyclotron are explained. Typical features of the synchro-cyclotron, such as the beam capture problem, stable phase motion, and the extraction problem are discussed. The main design goals for beam injection are explained and special problems related to a central region with an internal ion source are considered. The principle of a Penning ion gauge source is addressed. The issue of vertical focusing in the cyclotron centre is briefly discussed. Several examples of numerical simulations are given. Different methods of (axial) injection are briefly outlined. Different solutions for beam extraction are described. These include the internal target, extracti...

Recent development and progress of IBA cyclotrons

Energy Technology Data Exchange (ETDEWEB)

Kleeven, W., E-mail: Willem.Kleeven@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Abs, M., E-mail: Michel.Abs@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Delvaux, J.L., E-mail: Jean-Luc.Delvaux@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Forton, E., E-mail: Eric.Forton@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Jongen, Y., E-mail: Yves.Jongen@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Medeiros Romao, L., E-mail: Luis.MedeirosRomao@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Nactergal, B., E-mail: Benoit.Nactergal@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Nuttens, V., E-mail: Vincent.Nuttens@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Servais, T., E-mail: Thomas.Servais@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Vanderlinden, T., E-mail: Thierry.Vanderlinden@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Zaremba, S., E-mail: Simon.Zaremba@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium)

2011-12-15

Several cyclotron development projects were recently realized by Ion Beam Applications S.A. (IBA). This contribution presents three of them: (i) the intensity enhancement of the Cyclone 30 cyclotron, a machine mainly used for the production of SPECT isotopes. This project is related with the increased demand for {sup 201}Tl because of the shortage of Mo/Tc generators from nuclear reactors, (ii) development of a new versatile multiple-particle K = 30 isotope-production cyclotron (the Cyclone 30XP) being able to accelerate H{sup -}, D{sup -} and also {alpha}-particles. The {alpha}-beam of this cyclotron will allow the production of new therapeutic isotopes (e.g. {sup 211}At) and (iii) commissioning of the Cyclone 70 cyclotron installed for Arronax in France. This machine is similar to the C30XP but provides higher energy (K = 70) and allows research on new types of medical isotopes.

A new slow positron beam facility using a compact cyclotron

International Nuclear Information System (INIS)

Hirose, Masafumi

1998-01-01

In 1993, Sumitomo Heavy Industries became the first in the world to successfully produce a slow positron beam using a compact cyclotron. Slow positron beam production using an accelerator had mainly consisted of using an electron linear accelerator (LINAC). However, the newly developed system that uses a compact cyclotron enabled cost reduction, downsizing of equipment, production of a DC slow positron beam, a polarized slow positron beam, and other benefits. After that, a genuine slow positron beam facility was developed with the construction of compact cyclotron No.2, and beam production in the new facility has already been started. The features of this new slow positron beam facility are explained below. 1) It is the world's first compact slow positron beam facility using a compact cyclotron. 2) It is the only genuine slow positron beam facility in the world which incorporates the production and use of a slow positron beam in the design stage of the cyclotron. To use a slow positron beam for non-destructive detection of lattice defects in semiconductor material, it is necessary to convert the beam into ultra-short pulses of several hundreds of pico-seconds. Sumitomo Heavy Industries has devised a new short-pulsing method (i.e. an induction bunching method) that enables the conversion of a slow positron beam into short pulses with an optimum pulsing electric field change, and succeeded in converting a slow positron beam into short pulses using this method for the first time in the world. Non-destructive detection of lattice defects in semiconductor material using this equipment has already been started, and some information about the depth distribution, size, density, etc. of lattice defects has already been obtained. (J.P.N.)

Status of Simulations for the Cyclotron Laboratory at the Institute for Nuclear Research and Nuclear Energy

Science.gov (United States)

Asova, G.; Goutev, N.; Tonev, D.; Artinyan, A.

2018-05-01

The Institute for Nuclear Research and Nuclear Energy is preparing to operate a high-power cyclotron for production of radioisotopes for nuclear medicine, research in radiochemistry, radiobiology, nuclear physics, solid state physics. The cyclotron is a TR24 produced by ASCI, Canada, capable to deliver proton beams in the energy range of 15 to 24 MeV with current as high as 400 µA. Multiple extraction lines can be fed. The primary goal of the project is the production of PET and SPECT isotopes as 18F, 67,68Ga, 99mTc, etc. This contribution reports the status of the project. Design considerations for the cyclotron vault will be discussed for some of the target radioisotopes.

Synchro-cyclotron

CERN Multimedia

CERN PhotoLab

1972-01-01

The electromagnetic coil which forms the first section of the proton extraction channel in the improved synchro-cyclotron. The photograph shows the positioning gear and the current septum. An extraction efficiency above 50% is expected.

Overview of the future upgrade of the INFN-LNS superconducting cyclotron

Science.gov (United States)

Calabretta, Luciano; Calanna, Alessandra; Cuttone, Giacomo; D'Agostino, Grazia; Rifuggiato, Danilo; Domenico Russo, Antonio

2017-06-01

The LNS Superconducting Cyclotron, named “Ciclotrone Superconduttore” (CS), has been in operation for more than 20 years. A wide range of ion species from hydrogen to lead, with energy in the range 10 to 80 AMeV, have been delivered to users. The maximum beam power is limited to 100 W due to the beam dissipation on the electrostatic deflectors. To fulfil the demand of users aiming at studying rare processes in nuclear physics, an upgrade of the cyclotron is necessarily intended to increase the intensity of ion beams with mass lower than 40 a.m.u. up to a power 10 kW. This will be achieved by means of extraction by stripping. This solution needs to replace the cryostat including the superconducting coils. The present capability of the cyclotron will be maintained, i.e. all the ion species allowed by the operating diagram will be available, being extracted by electrostatic extraction. In addition to the high power beams for nuclear physics, it will be possible to produce medical radioisotopes like 211At using an internal target.

Acceleration of tritons with a compact cyclotron

International Nuclear Information System (INIS)

Wegmann, H.; Huenges, E.; Muthig, H.; Moringa, H.

1981-01-01

With the compact cyclotron at the Faculty of Physics of the Technical University of Munich, tritons have been accelerated to an energy of 7 MeV. A safe and reliable operation of the gas supply for the ion source was obtained by a new tritium storage system. A quantity of 1500 Ci tritium is stored by two special Zr-Al getter pumps in a non-gaseous phase. The tritium can be released in well-defined amounts by heating the getter material. During triton acceleration the pressure in the cyclotron vacuum chamber is maintained only by a large titanium sputter-ion pump, thus forming a closed vacuum system without any exhaust of tritium contaminated gas. Any tritium contaminations in the air can be detected by an extremely sensitive tritium monitoring system. The triton beam with a maximum intensity of 30 μA has been used so far to produce neutron-rich radioisotopes such as 28 Mg, 43 K, or 72 Zn, which are successfully applied in tracer techniques in the studies of biological systems. (orig.)

Compact superconducting cyclotron C400 for hadron therapy

Energy Technology Data Exchange (ETDEWEB)

Jongen, Y.; Abs, M.; Blondin, A.; Kleeven, W.; Zaremba, S.; Vandeplassche, D. [IBA, Chemin du Cyclotron 3, B-1348 Louvain-la-Neuve (Belgium); Aleksandrov, V.; Gursky, S.; Karamyshev, O. [JINR, Joliot-Curie 6, 141980 Dubna, Moscow region (Russian Federation); Karamysheva, G., E-mail: gkaram@nu.jinr.r [JINR, Joliot-Curie 6, 141980 Dubna, Moscow region (Russian Federation); Kazarinov, N.; Kostromin, S.; Morozov, N.; Samsonov, E.; Shirkov, G.; Shevtsov, V.; Syresin, E.; Tuzikov, A. [JINR, Joliot-Curie 6, 141980 Dubna, Moscow region (Russian Federation)

2010-12-01

The compact superconducting isochronous cyclotron C400 has been designed by the IBA-JINR collaboration. It will be the first cyclotron in the world capable of delivering protons, carbon and helium ions for cancer treatment. The cyclotron construction is started this year within the framework of the Archade project (Caen, France). {sup 12}C{sup 6+} and {sup 4}He{sup 2+} ions will be accelerated to 400 MeV/uu energy and extracted by the electrostatic deflector, H{sub 2}{sup +} ions will be accelerated to the energy of 265 MeV/uu and extracted by stripping. The magnet yoke has a diameter of 6.6 m, the total weight of the magnet is about 700 t. The designed magnetic field corresponds to 4.5 T in the hills and 2.45 T in the valleys. Superconducting coils will be enclosed in a cryostat; all other parts of the cyclotron will be warm. Three external ion sources will be mounted on the switching magnet on the injection line located below the cyclotron. The main parameters of the cyclotron, its design, the current status of the development work on the cyclotron systems are presented.

Status report on cyclotron operation

International Nuclear Information System (INIS)

Kovacs, P.; Szuecs, I.; Ander, I.; Lakatos, T.; Fenyvesi, A.; Ditroi, F.; Takacs, S.; Tarkanyi, F.

2004-01-01

The operation of the cyclotron in 2003 was again concentrated to 9 months; January, July and August were reserved for maintenance, renewal works and holidays. The overall working time of the accelerator was 4051 hours. The cyclotron was available for users for 3682 hours. In order to improve the circumstances of the irradiations renewal and improvements were done. (N.T.)

Slow wave cyclotron maser

International Nuclear Information System (INIS)

Kho, T.H.; Lin, A.T.

1988-01-01

Cyclotron masers such as Gyrotrons and the Autoresonance Masers, are fast wave devices: the electromagnetic wave's phase velocity v rho , is greater than the electron beam velocity, v b . To be able to convert the beam kinetic energy into radiation in these devices the beam must have an initial transverse momentum, usually obtained by propagating the beam through a transverse wiggler magnet, or along a nonuniform guide magnetic field before entry into the interaction region. Either process introduces a significant amount of thermal spread in the beam which degrades the performance of the maser. However, if the wave phase velocity v rho v b , the beam kinetic energy can be converted directly into radiation without the requirement of an initial transverse beam momentum, making a slow wave cyclotron maser a potentially simpler and more compact device. The authors present the linear and nonlinear physics of the slow wave cyclotron maser and examine its potential for practical application

A national medical cyclotron facility: report to the Minister of Health by the Medical Cyclotron Committee

International Nuclear Information System (INIS)

1985-01-01

Research and training in nuclear medicine in Australia are both limited by the lack of a medical cyclotron facility. The Committee recommends the establishment of a national medical cyclotron to provide a supply of short-lived radioisotopes for research in relevant fields of medicine, and for diagnostic use in nuclear medicine

Development of cyclotron solid targetry

International Nuclear Information System (INIS)

D'Souza, J.; Deans, T.; Cryer, D.; Price, R.

2004-01-01

Full text: Western Australia's first medical cyclotron was recently installed in the Department of Medical Technology and Physics at Sir Charles Gairdner Hospital. The cyclotron is routinely used for 18 F production using a liquid target, and now research is being undertaken into solid target bombardment for production of novel isotopes such as 124 I, 64 Cu and 96 Tc. The IBA Cyclone 18/9 has a maximum proton beam energy of 18MeV and maximum beam current of 80μA. A proton beam is generated by the acceleration of H- ions in the evacuated cyclotron (10 -6 bar) which are then stripped of 2 electrons just prior to exiting a target port. Each port has two strippers which are made of 10μm thick carbon with dimensions 12mmxl3mm. Due to their thinness, the strippers are easily ruptured. The Cyclone 18/9 has 8 target ports. In order to fit a target onto the cyclotron when the cyclotron is already evacuated the target is first evacuated to 10 -3 bar by a roughing pump before an isolation valve at the port is opened. This stops any damage that may occur by the flow of air from the target reservoir to the cyclotron eg to the strippers. The first step in the project to develop solid targetry is to build a beam line in order to measure the beam profile. If successful, this design will be improved in order to have a beam line and target holder that are suitable for use in solid target bombardment. A 40cm beam line with an internal diameter of 3.6cm was built to fit onto the IBA Cyclone 18/9. The beam line, made out of aluminium, incorporates a step 5cm from the end at which a target material can be fitted. A cover fits onto the beam line, behind the target in order to maintain vacuum. The cover is held in place by the vacuum within the beam line. At the end of bombardment, the beam line can be isolated from the vacuum of the target and normal air pressure restored. In doing so the cover plate falls open and the target falls into a lead pot, ready for removal from the cyclotron

Study of the effect of irradiation of Mo targets at nuclear reactor

International Nuclear Information System (INIS)

Nieto, Renata C.; Lima, Ana Lucia V.P.; Silva, Nestor C. da; Osso Junior, Joao Alberto

2000-01-01

The most used radioisotope in nuclear medicine is 99m Tc, in the 99 Mo- 99m Tc generator form. 99 Mo can be produced by several nuclear reactions in reactors and cyclotrons. The cyclotron production is not technically and economically viable. The production in the reactor can be done in two different ways: by the fission of 235 U and by the 98 Mo(n,γ) 99 Mo reaction. A project for the production of 99 Mo by the activation of Mo and the preparation of gel type generators is under development at the 'Instituto de Pesquisas Energeticas e Nucleares'. In the present work, the radionuclidic impurities produced in the activation of MoO 3 , metallic Mo and Mo Zr gel were evaluated, as well as the radionuclidic purity of 99m Tc eluted from generators prepared. (author)

Decontamination of the activation product based on a legal revision of the cyclotron vault room on the non-self-shield compact medical cyclotron

International Nuclear Information System (INIS)

Komiya, Isao; Umezu, Yoshiyuki; Fujibuchi, Toshiou; Nakamura, Kazumasa; Baba, Shingo; Honda, Hiroshi

2016-01-01

The non-self-shield compact medical cyclotron and the cyclotron vault room were in operation for 27 years. They have now been decommissioned. We efficiently implemented a technique to identify an activation product in the cyclotron vault room. Firstly, the distribution of radioactive concentrations in the concrete of the cyclotron vault room was estimated by calculation from the record of the cyclotron operation. Secondly, the comparison of calculated results with an actual measurement was performed using a NaI scintillation survey meter and a high-purity germanium detector. The calculated values were overestimated as compared to the values measured using the Nal scintillation survey meter and the high-purity germanium detector. However, it could limit the decontamination area. By simulating the activation range, we were able to minimize the concrete core sampling. Finally, the appropriate range of radioactivated area in the cyclotron vault room was decontaminated based on the results of the calculation. After decontamination, the radioactive concentration was below the detection limit value in all areas inside the cyclotron vault room. By these procedures, the decommissioning process of the cyclotron vault room was more efficiently performed. (author)

Electron cyclotron emission from optically thin plasma in compact helical system

International Nuclear Information System (INIS)

Idei, Hiroshi; Kubo, Shin; Hosokawa, Minoru; Iguchi, Harukazu; Ohkubo, Kunizo; Sato, Teruyuki.

1994-01-01

A frequency spectrum of second harmonic electron cyclotron emission was observed for an optically thin plasma produced by fundamental electron cyclotron heating in a compact helical system. A radial electron temperature profile deduced from this spectrum neglecting the multiple reflections effect shows a clear difference from that measured by Thomson scattering. We relate the spectrum with the electron temperature profile by the modified emission model including the scrambling effect. The scrambling effect results from both mode conversion and change in the trajectory due to multiple reflections of the emitting ray at the vessel wall. The difference between the two temperature profiles is explained well by using the modified emission model. Reconstruction of the electron temperature profile from the spectrum using this model is also discussed. (author)

Method of enhancing cyclotron beam intensity

Science.gov (United States)

Hudson, Ed D.; Mallory, Merrit L.

1977-01-01

When an easily ionized support gas such as xenon is added to the cold cathode in sources of the Oak Ridge Isochronous Cyclotron, large beam enhancements are produced. For example, .sup.20 Ne.sup.7+ is increased from 0.05 enA to 27 enA, and .sup.16 O.sup.5+ intensities in excess of 35 e.mu.A have been extracted for periods up to 30 minutes. Approximately 0.15 cc/min of the easily ionized support gas is supplied to the ion source through a separate gas feed line and the primary gas flow is reduced by about 30%.

Rf structure of superconducting cyclotron for therapy application

International Nuclear Information System (INIS)

Takekoshi, Hidekuni; Matsuki, Seishi; Mashiko, Katuo; Shikazono, Naomoto.

1981-01-01

Advantages of fast neutrons in therapeutical application are now widely recognized. Fast neutrons are generated by bombarding a thick beryllium target with high energy protons and deuterons. The AVF cyclotrons which deliver 50 MeV protons and 25 MeV deuterons are commonly used and are commercially available now. At the treatment usually rotational irradiation is taken to prevent an injury to normal tissue from the high LET effect of fast neutrons. The construction cost of both cyclotrons and isocentric irradiation installation are relatively high, so that the spread of neutron therapy is obstructed. A superconducting cyclotron for neutron therapy application was proposed by a Chalk River group. This low cost design allows the installation to be a dedicated facility located in a hospital, and small size allows installations of the complete cyclotron in a rotatable gantry. The design studies of the superconducting cyclotron based on this idea are going on at Kyoto University. The full scale model experiments for a rf structure of the cyclotron were carried out. (author)

Commissioning of cryogen delivery system for superconducting cyclotron magnet

International Nuclear Information System (INIS)

Pal, G.; Nandi, C.; Bhattacharyya, T.K.; Chaudhuri, J.; Bhandari, R.K.

2005-01-01

A K-500 superconducting cyclotron is being constructed at VECC Kolkata. The cryogen delivery system distributes liquid helium and liquid nitrogen to the superconducting cyclotron. Liquid helium is required to cool the cyclotron magnet and cryopanels. Liquid nitrogen is used to reduce the capacity of the helium liquefier. This paper describes the system, the current status and the commissioning experiences of cryogen delivery system for cyclotron magnet. (author)

Progress report: Variable Energy Cyclotron Centre, Calcutta

International Nuclear Information System (INIS)

1999-01-01

This volume of the progress report brings out the scientific and technical activities of Variable Energy Cyclotron Centre, Calcutta during the year 1999. This includes brief review of the various R and D activities of the Centre and outside users of the cyclotron from the universities and other research institutes. The operational activities of the cyclotron with ECR ion sources, accelerator oriented research activities, activities on detector, target and electronics are reported. The activities of the Computer and Informatics group are described. The status report of the ongoing projects is also provided. The main activities of the superconducting cyclotron project, radioactive ion beam project, heavy ion experimental facility, advanced computational facility, recovery and analysis of helium from hot springs and material science research are described

10 GHz ECRIS for Warsaw Cyclotron

CERN Document Server

Sudlitz, K

1999-01-01

Cusp type, 10 GHz ECRIS has been built and tested earlier. For obtaining intensive beams, more relevant for cyclotron, cusp geometry has been replaced by hexapole. Discharge chamber (stainless steel, 50 mm diameter, 250 mm long) is an extension of a coaxial line, feeding RF (9,6 GHz, up to 200 W) to the plasma. The NdFeB hexapole (0,52 T on the surface) has been used. The axial magnetic field is created by water cooled coils. The axial injection line dedicated to K160 isochronous heavy ion cyclotron has been constructed. The line consists of Glaser lenses, double focusing magnet, solenoid and mirror type inflector. The system provides sufficient transmission of the beam from ECR ion source to the firsts orbits of the cyclotron for m/q ranging from 7 to 2. After successful initial tests which were done in July 1997 the ECRIS serves as an external source for Warsaw Cyclotron.

Radiochemical studies relevant to cyclotron production of the radionuclides 71,72As, 68Ge/68Ga and 76,77,80mBr

International Nuclear Information System (INIS)

Shehata, Mohamed Mostafa Mostafa

2011-01-01

.c.a. radiogallium was studied using different solvents. Additionally separation of n.c.a. radiobromine was also done via solvent extraction using TOA in o-xylene. Finally an optimized procedure applicable to the production of 77 Br and 67 Ga was developed, and the quality control of the products was done. The nuclear reaction cross section of the Auger electron emitting radionuclide 80m Br (T 1/2 =4.4 h), was determined for its production using enriched 80 Se targets. Thin 80 Se samples were irradiated with incident protons of energies up to 18 MeV and the induced radioactivity was measured via nondestructive γ-ray spectrometery, allowing the determination and extension of the excitation function of the 80 Se(p,n) 80m Br reaction. The possible thick target yield was calculated and the energy range for production is discussed, especially with regard to the yield and radionuclidic purity of the produced radionuclide.

Production of radioisotopes by 1.5 m cyclotron and their utilization

International Nuclear Information System (INIS)

Niu Fang

1987-01-01

Radioisotopes characterized by nuclear property and uses can be produced on the accelerator, especially those playing an important role in scientific researches and biomedical uses. The status of Radioisotopes produced by 1.5 m cyclotron and their applications in our institute are summarized in this paper. The details of preparation and the results of use for radioactive sources, radiochemicals, radiopharmaceuticals of 57 Co, 109 Cd, 68 Ge- 68 Ga, and 167 Tm are given respectively. (author)

Prospects for the methods of radionuclide production

International Nuclear Information System (INIS)

Karamyan, S.A.; Dmitriev, S.N.

2014-01-01

Methods of radionuclide production for the nuclear-medicine purposes are described. In a budget approach, the application of low-energy accelerators is especially advantageous. Intense flux of bremsstrahlung at electron accelerators or high-current cyclotron beams of alpha particles must supply a great yield for many isotopes. The choice of a target material and of the projectile energy provides enough variation for concrete species formation. The innovating procedures are here proposed for optimizing of methods, for instance, application of the noble-gas target for production and transport of activities. The known and new variants of the 'generator' scheme are discussed. Many isotopes are listed as promising in the context of the therapeutic and theragnostic applications. Among them are isotopes/isomers emitting soft radiation for the selective and careful body treatment, also the positron emitters for PET, and the halogen and alkali-metal species convenient for chemical separation.

Electron cyclotron harmonic wave acceleration

Science.gov (United States)

Karimabadi, H.; Menyuk, C. R.; Sprangle, P.; Vlahos, L.

1987-01-01

A nonlinear analysis of particle acceleration in a finite bandwidth, obliquely propagating electromagnetic cyclotron wave is presented. It has been suggested by Sprangle and Vlahos in 1983 that the narrow bandwidth cyclotron radiation emitted by the unstable electron distribution inside a flaring solar loop can accelerate electrons outside the loop by the interaction of a monochromatic wave propagating along the ambient magnetic field with the ambient electrons. It is shown here that electrons gyrating and streaming along a uniform, static magnetic field can be accelerated by interacting with the fundamental or second harmonic of a monochromatic, obliquely propagating cyclotron wave. It is also shown that the acceleration is virtually unchanged when a wave with finite bandwidth is considered. This acceleration mechanism can explain the observed high-energy electrons in type III bursts.

Electron cyclotron harmonic wave acceleration

International Nuclear Information System (INIS)

Karimabadi, H.; Menyuk, C.R.; Sprangle, P.; Vlahos, L.; Salonika Univ., Greece)

1987-01-01

A nonlinear analysis of particle acceleration in a finite bandwidth, obliquely propagating electromagnetic cyclotron wave is presented. It has been suggested by Sprangle and Vlahos in 1983 that the narrow bandwidth cyclotron radiation emitted by the unstable electron distribution inside a flaring solar loop can accelerate electrons outside the loop by the interaction of a monochromatic wave propagating along the ambient magnetic field with the ambient electrons. It is shown here that electrons gyrating and streaming along a uniform, static magnetic field can be accelerated by interacting with the fundamental or second harmonic of a monochromatic, obliquely propagating cyclotron wave. It is also shown that the acceleration is virtually unchanged when a wave with finite bandwidth is considered. This acceleration mechanism can explain the observed high-energy electrons in type III bursts. 31 references

83-inch cyclotron research program. Final report

International Nuclear Information System (INIS)

Parkinson, W.C.

1983-07-01

In June of 1960 the US Atomic Energy Commission authorized the construction of a modern variable energy cyclotron facility at The University of Michigan to be used for research in nuclear spectroscopy. The Legislature of the State of Michigan made available funds for construction of a building to house the 83-inch cyclotron and auxiliary equipment as well as the University's remodeled 42-inch cyclotron. The research program centered around the 83-inch cyclotron was funded by the AEC and its successors, the Energy Research and Development Administration (ERDA) and the Department of Energy (DOE), from September 1964 through March 1977. The program represented a continuation of the research effort using the 42-inch cyclotron facility which had been supported continuously by the AEC since February 1950. This final report to DOE briefly describes the research facility, the research program, and highlights the principal accomplishments of the effort. It begins with a historical note to place this effort within the context of nuclear physics research in the Department of Physics of the University of Michigan

Recycling and recommissioning a used biomedical cyclotron

International Nuclear Information System (INIS)

Carroll, L.R.; Ramsey, F.; Armbruster, J.; Montenero, M.

2001-01-01

Biomedical Cyclotrons have a very long life, but there eventually comes a time when any piece of equipment has to be retired from service. From time to time, we have the opportunity to help find new homes for used cyclotrons which, with relatively modest overhaul and refurbishment, can have many additional years of productive service, and thus represent a very valuable asset. The reasons for retiring a cyclotron vary, of course, but in our experience it is often due to an institution's changing priorities or changing needs, rather than the due to any fundamental age-related deficiency in the cyclotron itself. In this paper we will report on the relocation and successful restoration of a used TCC CP-42 cyclotron, which was moved from M.D. Anderson Hospital in Houston to Denton, Texas in early 1998, where it is presently being used for R and D and commercial production of biomedical isotopes. Ownership of the machine has been transferred to the University of North Texas; facility, manpower, and operational resources are provided by International Isotopes, Inc

Research and development studies into isotope production using the Harwell Variable Energy Cyclotron

International Nuclear Information System (INIS)

Nichols, A.L.; Bett, R.; Cuninghame, J.G.; Goodall, J.A.B.; Hill, J.I.S.; Sims, H.E.; Willis, H.H.

1979-11-01

Many useful radioisotopes can be produced by means of the Harwell Chemistry Division's Variable Energy Cyclotron. This report describes the preliminary preparation of a number of these neutron deficient isotopes (i.e. F18, S38, Fe52, Sr82-Rb82, Nb92m, Rh99, I123, Xe125, Tl201, Pu236, Pu237). Recently a targetry development programme has been initiated to optimise isotope yields. Gas, liquid and solid targets have been designed that can be quickly and safely removed from the cyclotron beam-line so that the target activity can be rapidly processed after the irradiation, if necessary. (author)

Introduction to ECR [electron cyclotron resonance] sources in electrostatic machines

International Nuclear Information System (INIS)

Olsen, D.K.

1989-01-01

Electron Cyclotron Resonance (ECR) ion source technology has developed rapidly since the original pioneering work of R. Geller and his group at Grenoble in the early 1970s. These ion sources are capable of producing intense beams of highly charged positive ions and are used extensively for cyclotron injection, linac injection, and atomic physics research. In this paper, the possible use of ECR heavy-ion sources in the terminals of electrostatic machines is discussed. The basic concepts of ECR sources are reviewed in the next section using the ORNL source as a model. The possible advantages of ECR sources over conventional negative ion injection and foil stripping are discussed in Section III. The last section describes the possible installation of an ECR source in a large machine such as the HHIRF 25-MV Pelletron. 6 refs., 4 figs., 1 tab

Status and prospects on radioisotope production in Korea

International Nuclear Information System (INIS)

Han, H. S.; Cho, W. K.; Park, U. J.; Hong, Y. D.; Park, K. B.

2002-01-01

In Korea, radioisotopes has been produced using small-sized research reactors (TRIGA Mark II, III) from 1961 to 1995. The Korea Atomic Energy Research Institute (KAERI) completed the High-flux Advanced Neutron Application Reactor (HANARO) in 1995 and a radioisotope production facilities (RIPF) in 1997. Medical and industrial radionuclides such as 131 I, 99m Tc, 166 Ho, 192 Ir and 60 Co, are routinely produced utilizing HANARO. Several hundreds kilo curies of these nuclides were supplied to domestic users in 2001. The Korea Cancer Center Hospital (KCCH) first installed a cyclotron (MC-50) for neutron therapy and RI production in 1984. At present, the cyclotron routinely produced radionuclides such as 201 TI, 67 Ga, 123 I and 18 F. Also, it is capable of producing several radionuclides, including 111 In, 51 Cr, 124 I, 54 Mn, 22 Na, etc. Baby cyclotrons were installed in Seoul National University Hospital, Sam sung Medical Center and Asan Medical Center. The main purpose of the introduction of baby cyclotrons was to produce short-lived positron emitters such as 18 F, 15 O and 11 C for PET. Radioisotope production facilities were imported and installed as subsidiaries of cyclotron. In Korea, more than 60 kinds of radioisotopes are currently used in the field of their applications and most of them are imported form foreign vendors. For the quality assurance of final products such as radiopharmaceuticals and industrial sources, facilities for production should be installed and maintained in accordance with regulation rules and also the production system should be operated under quality management system. Since 1992 the Korean government has been encouraging Mid and Long Term Nuclear R and D Programs to enhance capability in nuclear technology development. In order to actively promote the utilization, research and development of technology applying radiation and RI, the Korean government established 'a comprehensive promotion plan for utilization, research and development

Development of a Medical Cyclotron Production Facility

Science.gov (United States)

Allen, Danny R.

2003-08-01

Development of a Cyclotron manufacturing facility begins with a business plan. Geographics, the size and activity of the medical community, the growth potential of the modality being served, and other business connections are all considered. This business used the customer base established by NuTech, Inc., an independent centralized nuclear pharmacy founded by Danny Allen. With two pharmacies in operation in Tyler and College Station and a customer base of 47 hospitals and clinics the existing delivery system and pharmacist staff is used for the cyclotron facility. We then added cyclotron products to contracts with these customers to guarantee a supply. We partnered with a company in the process of developing PET imaging centers. We then built an independent imaging center attached to the cyclotron facility to allow for the use of short-lived isotopes.

Development of a Medical Cyclotron Production Facility

International Nuclear Information System (INIS)

Allen, Danny R.

2003-01-01

Development of a Cyclotron manufacturing facility begins with a business plan. Geographics, the size and activity of the medical community, the growth potential of the modality being served, and other business connections are all considered. This business used the customer base established by NuTech, Inc., an independent centralized nuclear pharmacy founded by Danny Allen. With two pharmacies in operation in Tyler and College Station and a customer base of 47 hospitals and clinics the existing delivery system and pharmacist staff is used for the cyclotron facility. We then added cyclotron products to contracts with these customers to guarantee a supply. We partnered with a company in the process of developing PET imaging centers. We then built an independent imaging center attached to the cyclotron facility to allow for the use of short-lived isotopes

Cyclotron radiation by a multi-group method

International Nuclear Information System (INIS)

Chu, T.C.

1980-01-01

A multi-energy group technique is developed to study conditions under which cyclotron radiation emission can shift a Maxwellian electron distribution into a non-Maxwellian; and if the electron distribution is non-Maxwellian, to study the rate of cyclotron radiation emission as compared to that emitted by a Maxwellian having the same mean electron density and energy. The assumptions in this study are: the electrons should be in an isotropic medium and the magnetic field should be uniform. The multi-group technique is coupled into a multi-group Fokker-Planck computer code to study electron behavior under the influence of cyclotron radiation emission in a self-consistent fashion. Several non-Maxwellian distributions were simulated to compare their cyclotron emissions with the corresponding energy and number density equivalent Maxwellian distribtions

Development of the RF cavity for the SKKUCY-9 compact cyclotron

International Nuclear Information System (INIS)

Shin, Seungwook; Lee, Jongchul; LEE, Byeong-No; Ha, Donghyup; Namgoong, Ho; Chai, Jongseo

2015-01-01

A 9 MeV compact cyclotron, named SKKUCY-9, for a radiopharmaceutical compound especially fludeoxyglucose (FDG) production for a positron emission tomography (PET) machine was developed at Sungkyunkwan University. H − ions which are produced from a Penning Ionization Gauge(PIG) ion source, travel through a normal conducting radio frequency (RF) cavity which operates at 83.2 MHz for an acceleration and electro-magnet for a beam focusing until the ions acquire energy of about 9 MeV. For installation at a small local hospital, our SKKUCY-9 cyclotron is developed to be compact and light-weight, comparable to conventional medical purpose cyclotrons. For compactness, we adapted a deep valley and large angle hill type for the electro-magnet design. Normally a RF cavity is installed inside of the empty space of the magnet valley region, which is extremely small in our case. We faced problems such as difficulties of installing the RF cavity, low Q-value. Despite of those difficulties, a compact RF cavity and its system including a RF power coupler to feed amplified RF power to the RF cavity and a fine tuner to compensate RF frequency variations was successfully developed and tested

Development of the RF cavity for the SKKUCY-9 compact cyclotron

Science.gov (United States)

Shin, Seungwook; Lee, Jongchul; LEE, Byeong-No; Ha, Donghyup; Namgoong, Ho; Chai, Jongseo

2015-09-01

A 9 MeV compact cyclotron, named SKKUCY-9, for a radiopharmaceutical compound especially fludeoxyglucose (FDG) production for a positron emission tomography (PET) machine was developed at Sungkyunkwan University. H- ions which are produced from a Penning Ionization Gauge(PIG) ion source, travel through a normal conducting radio frequency (RF) cavity which operates at 83.2 MHz for an acceleration and electro-magnet for a beam focusing until the ions acquire energy of about 9 MeV. For installation at a small local hospital, our SKKUCY-9 cyclotron is developed to be compact and light-weight, comparable to conventional medical purpose cyclotrons. For compactness, we adapted a deep valley and large angle hill type for the electro-magnet design. Normally a RF cavity is installed inside of the empty space of the magnet valley region, which is extremely small in our case. We faced problems such as difficulties of installing the RF cavity, low Q-value. Despite of those difficulties, a compact RF cavity and its system including a RF power coupler to feed amplified RF power to the RF cavity and a fine tuner to compensate RF frequency variations was successfully developed and tested.

Experimental monitoring of ozone production in a PET cyclotron facility

International Nuclear Information System (INIS)

Zanibellato, L.; Cicoria, G.; Pancaldi, D.; Boschi, S.; Mostacci, D.; Marengo, M.

2010-01-01

Ozone produced from radiolytic processes was investigated as a possible health hazard in the working environment at the University Hospital 'S.Orsola-Malpighi' PET facility. Intense radiation fields can generate ozone, known to be the most toxic gas produced by ionizing radiation around a particle accelerator. To evaluate ozone concentration in air, two different measurement campaigns were conducted with passive diffusion detectors. Comparison of the results with the concentration limits recommended by American Conference of Governmental Industrial Hygienists (ACGIH) demonstrated that ozone poses no health hazard to workers around a biomedical cyclotron.

Operation of the Karlsruhe Isochronous Cyclotron in 1975

International Nuclear Information System (INIS)

Schulz, F.; Schweickert, H.

1976-06-01

The operation of the Karlsruhe Isochronous Cyclotron in 1975 is briefly surveyed. The main reasons for a very short period for maintenance, repair and installation, and several additional efforts to improve the reliability of the accelerator installation, are discussed. The status and the results of several technical developments for the cyclotron are described: 1) the axial injection system; 2) computer aided cyclotron operation; 3) ion source development; 4) capacitive current measurement at the external beam; 5) new correction coils for the cyclotron; 6) improvement of the neutron time-of-flight spectrometer. As there is an increasing interest in using this type of accelerator for research in fields other than nuclear physics, it was felt appropriate to present short surveys on investigations at our cyclotron in 1975 in the fields of: 1) solid state physics; 2) engineering; 3) materials research; 4) nuclear medicine; 5) nuclear chemistry. (orig.) [de

Comparison of the production of medical radioisotopes on reactor and cyclotron

International Nuclear Information System (INIS)

Vucina, J.; Vuksanovic, Lj.; Dobrijevic, R.; Karanfilov, E.

1997-01-01

The production of radioisotopes for nuclear-medical applications can be performed either on nuclear reactor or on cyclotron. According to the nuclear reactions applied the radioisotopes of different physical characteristics can be produced. In the paper a comparison of the radioisotopes production given. Compared are the main steps in the production: choice of the nuclear reaction, targetry, irradiation and radiochemical separations performed on the irradiated target to isolate the desired radioisotope. The main characteristics of the produced radioisotopes are given and discussed. (author)

Present and future superconducting cyclotrons

International Nuclear Information System (INIS)

Nolen, J.A. Jr.

1987-01-01

This paper begins with a brief review of the status of present superconducting (SC) cyclotron projects, including the two which are currently operating and the six which are under construction. The next section summarizes the main features shared by five of these machines, while the third section presents recent developments and new concepts introduced in the other three ''second generation'' SC cyclotrons. Projects in early stages of development are discussed in the fourth section

NIRS-Chiba isochronous cyclotron 1975

International Nuclear Information System (INIS)

Ogawa, H.; Kumamoto, Y.; Yamada, T.; Hiramoto, T.

1976-02-01

The cyclotron facility installed according to the recommendation of the Atomic Energy Committee of Japan is used for neutron therapy and production of short-lived radioisotopes. Construction on the facility was started in the autumn of 1972, and completed in March 1974. Described are the following: beam transport and the experimental hall, machine research and improvement, machine time sharing and the particles and energies, characteristics of the cyclotron, and facility personnel. (auth.)

Knowledge based operation assist system for JAERI AVF cyclotron

International Nuclear Information System (INIS)

Agematsu, T.; Okumura, S.; Yokota, W.; Arakawa, K.; Murakami, T.; Okamura, T.

1992-01-01

We have developed two operation assist systems for easy and rapid operation of the JAERI AVF cyclotron. One is a knowledge based expert system guiding the sequence of parameter adjustment to inexperienced cyclotron operators. The other is a real-time simulation of the beam trajectories which are calculated from actual operating parameters. It graphically indicates feasible setting range of parameters that satisfies the acceptance of the cyclotron. These systems provide a human interface to adjust the parameters of the cyclotron. (author)

Isochronous cyclotron for thermonuclear reactors driving

International Nuclear Information System (INIS)

Alenitskij, Yu.G.

1998-01-01

The main requirements to an accelerator as a part of an electronuclear power plant are considered. The range of the parameters of the accelerated proton and deuteron beams, for which the isochronous cyclotron is the most profitable, is proposed. An opportunity of using the cyclotron to drive the research reactors of various types is considered

Overview of current status of SLR production and uses in Japan and other Asian countries

International Nuclear Information System (INIS)

Iio, M.

1985-01-01

The current status of short-lived radionuclide (SLR) production and use in Japan and other Asian countries is reviewed. The activities of six cyclotrons for medical use in Asia (except Japan) and Australia are reported. In Japan 10 dedicated medical cyclotrons were installed by 1983. Even though SLR application in Japan is in the cradle stage and is limited to only a few institutions, an analysis of these applications indicates the high efficacy of the dedicated small cyclotrons as compared with large, multipurpose cyclotrons. Because of the lack of high-energy commercial cyclotrons by 1982, a satisfactory iodine-123 supply of labeling quality has been limited. However, since two of the three medical cyclotron manufacturers and more than three positron camera producers are located there, Japan has high potential for the routine practice of nuclear medicine

Improvements of High Current/ Low Pressure Liquid And Gas Targets For Cyclotron Produced Radioisotopes

Energy Technology Data Exchange (ETDEWEB)

Hur, M. G. [Korea Atomic Energy Research Institute, Jeongup (Korea, Republic of); Hong, B. H. [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Chai, J. S. [SungKyunKwan University, Seoul (Korea, Republic of)

2009-07-01

The development of the C-11 cylindrical target with cooling fin for 13 MeV and 30 MeV proton beams and the development of pleated double-foil O-18 water target were carried out. For the test of new target system it was done at 2 pilots of cyclotron centres in Korea. The development of pleated double-foil O-18 water target was also executed. The pleated foil has the more advantages than flat foil. With the same beam bombarding the pleated foil with cooling had more yield of F-18production. CFD and FEM study were considered to design of the pleated foil and flat foil structure. (author)

New superconducting cyclotron driven scanning proton therapy systems

International Nuclear Information System (INIS)

Klein, Hans-Udo; Baumgarten, Christian; Geisler, Andreas; Heese, Juergen; Hobl, Achim; Krischel, Detlef; Schillo, Michael; Schmidt, Stefan; Timmer, Jan

2005-01-01

Since one and a half decades ACCEL is investing in development and engineering of state of the art particle-therapy systems. A new medical superconducting 250 MeV proton cyclotron with special focus on the present and future beam requirements of fast scanning treatment systems has been designed. The first new ACCEL medical proton cyclotron is under commissioning at PSI for their PROSCAN proton therapy facility having undergone successful factory tests especially of the closed loop cryomagnetic system. The second cyclotron is part of ACCEL's integrated proton therapy system for Europe's first clinical center, RPTC in Munich. The cyclotron, the energy selection system, the beamline as well as the four gantries and patient positioners have been installed. The scanning system and major parts of the control software have already been tested. We will report on the concept of ACCEL's superconducting cyclotron driven scanning proton therapy systems and the current status of the commissioning work at PSI and RPTC

Cyclotron for industrial production of radioisotopes: relevants characteristics

International Nuclear Information System (INIS)

Lima, Wanderley de

1997-01-01

The industrial production of radioisotopes requests cyclotrons with easy maintenance services, high productivity and low operation costs. To obtain this performance the experts on the have achieved excellent results, taking advantage of modern resources in calculation and modeling. Only by the maximum exploitation of the azimutal variation of the magnetic field, a physical concept introduced in 1967 with the isocronous cyclotrons, it was possible to construct cyclotrons with only 30% of the electrical consumption required by the former cyclotrons. On the other hand, the acceleration of negative ions enable the 100% accelerated beam utilization, without internal energy dissipation, obtaining beam intensities up to 1mA in continuous running which represents an increased factor of 15. Other construction parameters were optimized aiming at reliability and reduction in the components activation. Concerning energy consumption and the beam intensity supplied, a present cyclotron with 30 MeV and 300μA of protons current is 15 times more efficient than its precedent. (author). 6 refs., 1 fig., 2 tabs

Cyclotron production of radioactive gas from gaseous targets: inhomogeneity of the target activity - optimum flow rate of the carrier gas - cross sections

International Nuclear Information System (INIS)

Peters, J.-M.; Fiore, G. del; Quaglia, L.; Depresseux, J.-C.; Bartsch, P.

1979-01-01

When short-lived radioactive gases are produced by cyclotron-irradiated gaseous targets, the yield of activity, at the site of delivery, depends on the flow rate in the gas-carrying line. The authors improve a preliminarily published previous single model by the introduction of a supplementary hypothesis which takes into account the inhomogeneity of the activity in the gaseous target. By substituting the NTP volume of the gas in the irradiation cell Vsub(c) by a visible volume Vsub(a) depending on the flow rate and expressed by Vsub(a) = Vsub(infinity) +(V 0 - Vsub(infinity))exp(-kDsub(p)), they derive the following general expression for the optimum flow rate D which gives a maximum yield of production. D 2 -bD-bc-D 2 akexp(-kD)-abexp(-kD) = 0, a=lambda(V 0 -Vsub(infinity)), b = lambdaVsub(r), c = lambdaVsub(infinity), lambda = the decay constant of the radionuclide produced,Vsub(r) the inner volume of the gas-carrying line. The unknown parameters Vsub(r), Vsub(a), V 0 , Vsub(infinity), and k can be determined experimentally. The authors also suggest a new method for the determination of experimental cross sections with their gaseous target. (Auth.)

Robust high-yield ~1 TBq production of cyclotron based sodium [99mTc]pertechnetate.

Science.gov (United States)

Andersson, J D; Thomas, B; Selivanova, S V; Berthelette, E; Wilson, J S; McEwan, A J B; Gagnon, K

2018-03-02

This paper presents the irradiation and processing of high-current 100 Mo targets at the University of Alberta (UofA) in a GMP compliant setting. For purpose of comparison with a second production facility, additional studies at Centre Hospitalier Universitaire de Sherbrooke (CHUS) are also described. More than 70% of today's diagnostic radiopharmaceuticals are based on 99m Tc, however the conventional supply chain for obtaining 99m Tc is fragile. The aim of this work was to demonstrate reliable high yield production and processing of 99m Tc with medium-energy, high-current, cyclotrons. We used two cyclotrons (TR-24, Advanced Cyclotron Systems, Inc) for irradiations with 22 MeV or 24 MeV incident energy and 400 μA current up to a maximum of 6 h. The irradiated 100 Mo was dissolved using peroxide, basified using ammonium carbonate, and purified using a PEG-based solid phase extraction technique. High-yield productions with 22 MeV (400 μA, 6 h) yielded an average isolated [ 99m Tc]TcO 4 - yield of 878 GBq ± 99 GBq (23.7 Ci ± 2.7 Ci) decay corrected to EOB, n = 8 (isolated saturation yield: 4.36 ± 0.49 GBq/μA). Irradiations with 24 MeV (400 μA, 6 h) resulted in an average isolated [ 99m Tc]TcO 4 - yield of 993 GBq ± 100 GBq (26.8 Ci ± 2.7 Ci) decay corrected to EOB, n = 7 (isolated saturation yield: 4.97 ± 0.50 GBq/μA). These yields corresponds to 600-700 GBq (16-19 Ci) of [ 99m Tc]TcO 4 - at release (i.e. 3 hour post-EOB). For all tested batches, the QC results were within the recently published specifications in the European Pharmacopoeia. Reliable near-TBq production yields for 99m Tc can be obtained using medium-energy cyclotrons. This work presents evidence that medium-energy high-current cyclotrons can provide high yields of [ 99m Tc]TcO 4 - with radionuclidic impurities levels within the specifications of the existing European Pharmacopoeia monograph, indicating that this

Preparing a suitable solid target for generating copper-64 using a biomedical cyclotron

International Nuclear Information System (INIS)

Jeffery, Charmaine; Cryer, David; Chan, Sun; Asad, Ali; Fleming, Adam; Hubble, Lee

2009-01-01

Full text: Radiopharmaceutical research at SCGH has been advancing in the production of copper-64, a promising radionuclide for PET. Production has commenced using a self-manufactured solid target with alBA 18/9 cyclotron, via the 6 4 N i(p,n) 6 4 C u reaction pathway. One aspect of the project has been the preparation of a suitable solid target for irradiation. The chosen production method involves electrolysis of a solution of nickel ammonium sulphate in a self-manufactured electroplating cell, using a gold disk as the cathode for deposition of nickel metal. Various defects in the nickel surface were observed ∼ including cracks, formation of pits and inclusions, loose powder-like plating, lack of metallic lustre and lifting of the plated nickel. Several variables were investigated - including adjustment of the anode-cathode distance, anode composition, solution composition, and voltage/current settings. A suitable method that produced acceptable plating was achieved - the surface was then analysed to ensure there were no underlying defects. Three analytical techniques were used - AFM, SEM and optical profilometry. Two disks were ana lysed (approx. 3 0 m g of natNi plated). The depth of plating, evenness of plating and surface uniformity were of particular interest. Conclusions: Analysis revealed that the surface was not completely uniform (thinner at edges, 'well' in centre, with inclusions on the surface more prevalent than pitting), and required more nickel to be plated to reach optimum thickness. Final target specifications are still being optimised, however test irradiation of a solid target ( 3 1 n ickel, I l0 m g) proved that a sound solid target can be reliably produced and irradiated.

Recovery of 201Tl by ion exchange chromatography from proton bombarded thallium cyclotron targets

International Nuclear Information System (INIS)

Walt, T.N. van der; Naidoo, C.

2000-01-01

A method based on ion exchange chromatography is presented for the recovery of 201 Tl and its precursor 201 Pb from proton bombarded natural thallium cyclotron targets. After bombardment the target is dissolved in diluted nitric acid. Water, hydrazine and ammonium acetate are added to the solution and the lead radioisotopes separated from the thallium by cation exchange chromatography on a Bio-Rex 70 column. The sorbed lead radioisotopes are eluted with dilute nitric acid and the separation repeated on a second Bio-Rex 70 column. After elution of the remaining thallium the column is left for 32 hours and the 201 Tl formed by decay of 201 Pb is eluted with an ammonium acetate solution. The 201 Tl eluate is acidified with a HNO 3 -HBr-Br 2 mixture and the resulting solution is passed through an AG MP-1 anion exchanger column to remove any remaining lead isotopes. The 201 Tl is eluted with a hydrazine solution, the eluate evaporated to dryness and the 201 Tl finally dissolved in an appropriate solution to produce a 201 TlCl solution suitable for medical use. A high quality 201 Tl product is obtained containing ≤ 0.1 μg of Tl/mCi (37 MBq) 201 Tl. The radionuclidic impurities are less than the maximum values specified by the US Pharmacopoeia and the British Pharmacopoeia. (orig.)

Present situation of 'baby cyclotron'

International Nuclear Information System (INIS)

Yamada, Teruo

1981-01-01

A ''baby cyclotron'' has been developed by the Japan Steel Works, Ltd. Its No. 1 model (proton 9.4 MeV) was delivered to the Nakano Hospital of National Sanatorium in March, 1979. It is being used successfully for the production of 11 C, 13 N and 15 O and labeled compounds. The proton or deuteron particles accelerated in the cyclotron collide on target materials. The target box, which is automatically changeable, is directly installed to the accelerating box, thereby taking the safety measures for any leaking radiation. The following matters are described: the production of short-lived radioisotopes (RI yields and treatment); the processes of production in the Nakano Hospital, with No. 1 baby cyclotron, including the photosynthesis of labeled compounds such as 11 C-labeled glucose; the research on the automation in the synthesis of organic labeled compounds like 11 C-palmitic acid. (J.P.N.)

Cryogenic system for VECC K500 superconducting cyclotron

CERN Document Server

Pal, G; Bhattacharyya, T K; Bhandari, R K

2009-01-01

VEC Centre, Kolkata in India is at an advanced stage of commissioning a K500 superconducting cyclotron. The superconducting coil of the magnet for cyclotron is cooled by liquid helium. Three liquid helium cooled cryopanels, placed inside the Dees of the radiofrequency system, maintain the vacuum in the acceleration region of the superconducting cyclotron. The cryogenic system for magnet for cyclotron has been tested by cooling the coil and energizing the magnet. The cryogenic system for cryopanels has also been tested. Heater and temperature sensor were placed on the liquid helium cold head for cryopanel. The temperature of the cold head was observed to be below 20 K upto a heat load of 11.7 watt.

Cyclotron motion in a microwave cavity: an analog of the Lamb shift

International Nuclear Information System (INIS)

Brown, L.S.

1985-09-01

The interaction of a bound electron with the radiation field produced by the image charges that represent a surrounding metallic cavity produces a shift in its orbital frequency and in its radiative decay time. This is an analog to the Lamb shift in atomic systems, but it is purely a classical effect. We outline the calculation of the frequency shift and the change in the damping constant for a cyclotron motion at the midpoint of a lossy, cylindrical cavity

Variable-Energy Cyclotron for Proton Therapy Application

CERN Document Server

Alenitsky, Yu G; Vorozhtsov, A S; Glazov, A A; Mytsyn, G V; Molokanov, A G; Onishchenko, L M

2004-01-01

The requirements to characteristics of the beams used for proton therapy are considered. The operation and proposed cyclotrons for proton therapy are briefly described. The technical decisions of creation of the cyclotron with energy variation in the range 70-230 MeV and with current up to 100 nA are estimated. Taking into account the fact, that the size and cost of the cyclotron are approximately determined by the maximum proton energy, it is realistically offered to limit the maximum proton energy to 190 MeV and to elaborate a cyclotron project with a warm winding of the magnet for acceleration of H^{-} ions. The energy of the extracted protons for each run is determined by a stripped target radius in the vacuum chamber of the accelerator, and the radiation dose field for the patient is created by the external devices using the developed techniques.

General aspects of the cyclotrons and radiochemical separation of: 11 C, 15 O, 18 F and 14 N

International Nuclear Information System (INIS)

Alanis M, J.

1997-07-01

The particle accelerators, as the cyclotrons, are extraordinarily important as tools for the radioisotope production and its application in the area of the medicine. In this time, another method exists for the production of artificial radioisotopes, based on the irradiation of samples with alpha particles or with neutrons coming from a natural radioisotope being obtained a neutron source (Ra + Be, Rn + Be, Po + Be). However, its can be obtained a great quantity of radioisotopes by means of cyclotrons in very short time, compared with other methods. After the second world war, artificial radioisotopes took place by means of reactors and its had many applications, not only medical and in little time the accelerators were manufactured that were more indispensable that the reactors to produce radioisotopes with medical aims. For this reason, the accelerators, in few years became in machines very important for the production of artificial radioisotopes and consequently its were developed techniques of radioactive traces progressively more sophisticated, since it is evident that the production of radioactive nuclei through nuclear reactors its cannot satisfy all the demands. In general terms, only the neutrons can be used as nuclear projectiles in reactors and as a result, the production spectra of radioisotopes is limited and as alternative it is unavoidable that the cyclotrons are a good tool for this end. The use of a cyclotron to produce radioisotopes, it can be justified, only if the following conditions are completed. 1. If the radioisotopes of an element produced in a reactor don't favor with the nuclear properties for the purposes of the traced studies, for example: if the half life is very short or very big, if the decay system not to suit him. 2. If the wanted radioisotope cannot produce in the reactor with enough specific activity. (Author)

Production and dosimetric aspects of the potent Auger emitter 58mCo for targeted radionuclide therapy of small tumors

International Nuclear Information System (INIS)

Thisgaard, H.; Elema, D.R.; Jensen, M.

2011-01-01

Purpose: Based on theoretical calculations, the Auger emitter 58m Co has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state 58g Co is unfortunately unavoidable, as is ingrowth of the ground state following the isomeric decay of 58m Co. The impact of 58g Co as a β + - and γ-emitting impurity should be included in the dosimetric analysis. The purpose of this study was to investigate this critical part of dosimetry based on experimentally determined production yields of 58m Co and 58g Co using a low-energy cyclotron. Also, the cellular S-values for 58m Co have been calculated and are presented here for the first time. Methods: 58m Co was produced via the 58 Fe(p,n) 58m Co nuclear reaction on highly enriched 58 Fe metal. In addition, radiochemical separations of produced radio-cobalt from nat Fe target material were performed. The theoretical subcellular dosimetry calculations for 58m Co and 58g Co were performed using the MIRD formalism, and the impact of the increasing ground state impurity on the tumor-to-normal-tissue dose ratios (TND) per disintegration as a function of time after end of bombardment (EOB) was calculated. Results: 192 ± 8 MBq of 58m Co was produced in the irradiation corresponding to a production yield of 10.7 MBq/μAh. The activity of 58g Co was measured to be 0.85% ± 0.04% of the produced 58m Co activity at EOB. The radio-cobalt yields in the rapid separations were measured to be >97% with no detectable iron contaminations in the cobalt fractions. Due to the unavoidable coproduction and ingrowth of the long-lived ground state 58g Co, the TND and the potency of the 58m Co decrease with time after EOB. If a future treatment with a 58m Co labeled compound is not initiated before, e.g., 21 h after EOB, the resulting TND will be approximately 50% of the TND of 'pure' 58m Co as a result of the increased normal tissue dose from

INTERACTION OF NEUTRAL BEAM INJECTED FAST IONS WITH ION CYCLOTRON RESONANCE FREQUENCY WAVES

International Nuclear Information System (INIS)

CHOI, M.; CHAN, V.S.; CHIU, S.C.; OMELCHENKO, Y.A.; SENTOKU, Y.; STJOH, H.E.

2003-01-01

OAK B202 INTERACTION OF NEUTRAL BEAM INJECTED FAST IONS WITH CYCLOTRON RESONANCE FREQUENCY WAVES. Existing tokamaks such as DIII-D and future experiments like ITER employ both NB injection (NBI) and ion-cyclotron resonance heating (ICRH) for auxiliary heating and current drive. The presence of energetic particles produced by NBI can result in absorption of the Ion cyclotron radio frequency (ICRF) power. ICRF can also interact with the energetic beam ions to alter the characteristics of NBI momentum deposition and resultant impact on current drive and plasma rotation. To study the synergism between NBI and ICRF, a simple physical model for the slowing-down of NB injected fast ions is implemented in a Monte-Carlo rf orbit code. This paper presents the first results. The velocity space distributions of energetic ions generated by ICRF and NBI are calculated and compared. The change in mechanical momentum of the beam and an estimate of its impact on the NB-driven current are presented and compared with ONETWO simulation results

New production cross sections for the theranostic radionuclide 67Cu

Science.gov (United States)

Pupillo, Gaia; Sounalet, Thomas; Michel, Nathalie; Mou, Liliana; Esposito, Juan; Haddad, Férid

2018-01-01

The cross sections of the 68Zn(p,2p)67Cu, 68Zn(p,2n)67Ga and 68Zn(p,3n)66Ga reactions were measured at the ARRONAX facility by using the 70 MeV cyclotron, with particular attention to the production of the theranostic radionuclide 67Cu. Enriched 68Zn material was electroplated on silver backing and exposed to a low-intensity proton beam by using the stacked-foils target method. Since 67Cu and 67Ga radionuclides have similar half-lives and same γ-lines (they both decay to 67Zn), a radiochemical process aimed at Cu/Ga separation was mandatory to avoid interferences in γ-spectrometry measurements. A simple chemical procedure having a high separation efficiency (>99%) was developed and monitored during each foil processing, thanks to the tracer isotopes 61Cu and 66Ga. Nuclear cross sections were measured in the energy range 35-70 MeV by using reference reactions recommended by the International Atomic Energy Agency (IAEA) to monitor beam flux. In comparison with literature data a general good agreement on the trend of the nuclear reactions was noted, especially with latest measurements, but slightly lower values were obtained in case of 67Cu. Experimental results of the 68Zn(p,2p)67Cu, 68Zn(p,2n)67Ga and 68Zn(p,3n)66Ga reactions were also compared with the theoretical values estimated by using the software TALYS. The production yield of the theranostic radionuclide 67Cu was estimated considering the results obtained in this work.

Neutron field inside a PET Cyclotron vault room

International Nuclear Information System (INIS)

Vega C, H.R.; Mendez, R.; Iniguez, M.P.; Climent, J.M.; Penuelas, I.; Barquero, R.

2006-01-01

The neutron field around a Positron Emission Tomography cyclotron was investigated during 18 F radioisotope production with an 18 MeV proton beam. In this study the Ion Beam Application cyclotron, model Cyclone 18/9, was utilized. Measurements were carried out with a Bonner sphere neutron spectrometer with pairs of thermoluminescent dosemeters (TLD600 and TLD700) as thermal neutron detector. The TLDs readouts were utilized to unfold the neutron spectra at three different positions inside the cyclotron's vault room. With the spectra the Ambient dose equivalent was calculated. Neutron spectra unfolding were performed with the BUNKIUT code and the UTA4 response matrix. Neutron spectra were also determined by Monte Carlo calculations using a detailed model of cyclotron and vault room. (Author)

Ramifide resonators for cyclotrons

International Nuclear Information System (INIS)

Smirnov, Yu.V.

2000-01-01

The resonators with the conductors ramified form for cyclotrons are systematized and separated into the self-contained class - the ramified resonators for cyclotrons (Carr). The ramified resonators are compared with the quarter-wave and half-wave nonramified resonators, accomplished from the transmitting lines fragments. The CRR are classified into two types: ones with the additional structural element, switched in parallel and in series. The CRR may include several additional structural elements. The CRR calculations may be concluded by analytical methods - the method of matrix calculation or the method of telegraph equations and numerical methods - by means of the ISFEL3D, MAFIA and other programs [ru

Status Report on Cyclotron Operation

International Nuclear Information System (INIS)

Kovacs, P.; Szuecs, I.; Ander, I.; Lakatos, T.; Tarkanyi, F.

2004-01-01

Complete text of publication follows. The operation of the cyclotron in 2004 was concentrated to the usual 9 months; January, July and August were reserved for maintenance and holidays. The overall working time of the accelerator was 3554 hours, the time used for systematic maintenance was 450 hours. The breakdown periods amounted to 70 hours last year, included in it a 50 hours repair of RF control module under guarantee. The cyclotron was available for users during 3034 hours. The effectively used beam-on-target time statistics is summarized in Table 1. Developments: A new measuring site with a HPGe detector based gamma spectrometer is under installation in the basement of the Cyclotron Laboratory. A two channel pneumatic rabbit system is also under development to enable fast transport of samples between the new measuring site and two irradiation sites (the low intensity fast neutron irradiation site and the beam line used for Thin Layer Activation). (author)

Cyclotron-based neutron source for BNCT

Energy Technology Data Exchange (ETDEWEB)

Mitsumoto, T.; Yajima, S.; Tsutsui, H.; Ogasawara, T.; Fujita, K. [Sumitomo Heavy Industries, Ltd (Japan); Tanaka, H.; Sakurai, Y.; Maruhashi, A. [Kyoto University Research Reactor Institute (Japan)

2013-04-19

Kyoto University Research Reactor Institute (KURRI) and Sumitomo Heavy Industries, Ltd. (SHI) have developed a cyclotron-based neutron source for Boron Neutron Capture Therapy (BNCT). It was installed at KURRI in Osaka prefecture. The neutron source consists of a proton cyclotron named HM-30, a beam transport system and an irradiation and treatment system. In the cyclotron, H- ions are accelerated and extracted as 30 MeV proton beams of 1 mA. The proton beams is transported to the neutron production target made by a beryllium plate. Emitted neutrons are moderated by lead, iron, aluminum and calcium fluoride. The aperture diameter of neutron collimator is in the range from 100 mm to 250 mm. The peak neutron flux in the water phantom is 1.8 Multiplication-Sign 109 neutrons/cm{sup 2}/sec at 20 mm from the surface at 1 mA proton beam. The neutron source have been stably operated for 3 years with 30 kW proton beam. Various pre-clinical tests including animal tests have been done by using the cyclotron-based neutron source with {sup 10}B-p-Borono-phenylalanine. Clinical trials of malignant brain tumors will be started in this year.

NORTICA - a new code for cyclotron analysis

International Nuclear Information System (INIS)

Gorelov, D.; Johnson, D.; Marti, F.

2001-01-01

The new package NORTICA (Numerical ORbit Tracking In Cyclotrons with Analysis) of computer codes for beam dynamics simulations is under development at NSCL. The package was started as a replacement for the code MONSTER developed in the laboratory in the past. The new codes are capable of beam dynamics simulations in both CCF (Coupled Cyclotron Facility) accelerators, the K500 and K1200 superconducting cyclotrons. The general purpose of this package is assisting in setting and tuning the cyclotrons taking into account the main field and extraction channel imperfections. The computer platform for the package is Alpha Station with UNIX operating system and X-Windows graphic interface. A multiple programming language approach was used in order to combine the reliability of the numerical algorithms developed over the long period of time in the laboratory and the friendliness of modern style user interface. This paper describes the capability and features of the codes in the present state

NORTICA—a new code for cyclotron analysis

Science.gov (United States)

Gorelov, D.; Johnson, D.; Marti, F.

2001-12-01

The new package NORTICA (Numerical ORbit Tracking In Cyclotrons with Analysis) of computer codes for beam dynamics simulations is under development at NSCL. The package was started as a replacement for the code MONSTER [1] developed in the laboratory in the past. The new codes are capable of beam dynamics simulations in both CCF (Coupled Cyclotron Facility) accelerators, the K500 and K1200 superconducting cyclotrons. The general purpose of this package is assisting in setting and tuning the cyclotrons taking into account the main field and extraction channel imperfections. The computer platform for the package is Alpha Station with UNIX operating system and X-Windows graphic interface. A multiple programming language approach was used in order to combine the reliability of the numerical algorithms developed over the long period of time in the laboratory and the friendliness of modern style user interface. This paper describes the capability and features of the codes in the present state.

Specific features of the desion of a cyclotron for radioisotope production

International Nuclear Information System (INIS)

Akulova, N.V.; Bogdanov, P.V.; Ivanov, V.V.

1979-01-01

Results of development of an isochronous cyclotron for commercial production of Co 57 and Ga 67 isotopes are described. The accelerator is intended for proton acceleration up to 25 MeV at 1000-1500 mA intensity of inner beam and 200 mA intensity of external beam. An axial ion source with a hot cathode will be used in the cyclotron. Outer diameter of armour type electromagnet is 3130 mm, mass - 75 t, diameter of poles-150 cm and mean induction of magnetic field in a working gap amounts to 12 kgs. Accelerating chamber vessel is made of steel in the form of thick-wall hollow cylinder having 3130 mm outer diameter, 330 mm thickness and 380 mm height. Resonance system represents a quarter-wave line operating on 16.6 MHZ-frequency. Vacuum system is designed to produce and maintain residual pressure of 6.7x10 -4 Pa and 2.7x10 -3 Pa in the accelerating chamber which can be provided with two NDM-2 ion-getter pumps with an arc evaporator. The suggested constructive solution for electromagnet, accelerating chamber of the cyclotron and pumping system permitted to arrange the accelerator on the whole and to considerably decrease the level of ionizing radiations inside the chamber [ru

Chemistry and radiochemistry of As, Re and Rh isotopes relevant to radiopharmaceutical applications: high specific activity radionuclides for imaging and treatment.

Science.gov (United States)

Feng, Yutian; Phelps, Tim E; Carroll, Valerie; Gallazzi, Fabio; Sieckman, Gary; Hoffman, Timothy J; Barnes, Charles L; Ketring, Alan R; Hennkens, Heather M; Jurisson, Silvia S

2017-10-31

The chemistry and radiochemistry of high specific activity radioisotopes of arsenic, rhenium and rhodium are reviewed with emphasis on University of Missouri activities over the past several decades, and includes recent results. The nuclear facilities at the University of Missouri (10 MW research reactor and 16.5 MeV GE PETtrace cyclotron) allow research and development into novel theranostic radionuclides. The production, separation, enriched target recovery, radiochemistry, and chelation chemistry of 72,77 As, 186,188 Re and 105 Rh are discussed.

Development of baby cyclotron for PET in Korea

International Nuclear Information System (INIS)

Chai, J.S.; Kim, Y.S.; Hu, J.Y.; Shin, Y.C.; Yoon, M.H.

2001-01-01

Development of a 13 MeV cyclotron for Positron Emission Tomography (PET) has been in progress since April 1999 at the Korea Cancer Center Hospital (KCCH). The study has been carried out in a joint collaboration between KCCH and the Pohang University of Science and Technology (POSTECH). Increasing desire for an uninterrupted, reliable and timely supply of the isotopes to customers has prompted obtaining a dedicated 5-13 MeV cyclotron for PET applications and pursuing the purchase of another 30MeV medical cyclotron in the very near future. A decision has been made to design the PET cyclotron in Korea. This will not only ease the problems associated with maintenance during operation but also keep the door open for continuous upgrading of the machine in the future

An experimental study on cyclotron-Cherenkov radiation

Energy Technology Data Exchange (ETDEWEB)

Lee, C Y; Masuzaki, M; Yoshida, H; Toyosugi, N; Kamada, K; Ando, R [Kanazawa Univ. (Japan). Department of Physics

1997-12-31

Dielectric-loaded cylindrical waveguide configurations with an injected electron beam in which the growth rate of the cyclotron-Cherenkov instability surpasses that of the Cherenkov instability were sought by numerical treatment, and one configuration of this kind was found. This configuration consists of a metallic core and an outer metallic cylinder with a dielectric liner on the inner surface. Based on the calculations, an experimental device was designed and assembled to investigate experimentally radiation due to the cyclotron-Cherenkov instability. Beam propagation in the dielectric-loaded coaxial waveguide and microwave radiation due to the cyclotron-Cherenkov instability and the Cherenkov instability were studied. (author). 6 figs., 10 refs.

Leachability of radionuclides from cement solidified waste forms produced at operating nuclear power plants

International Nuclear Information System (INIS)

Croney, S.T.

1985-03-01

This study determined the leachability indexes of radionuclides contained in solidified liquid wastes from operating nuclear power plants. Different sizes of samples of cement-solidified liquid wastes were collected from two nuclear power plants - a pressurized water reactor and a boiling water reactor - to correlate radionuclide leaching from small- and full-sized (55-gallon) waste forms. Diffusion-based model analysis (ANS 16.1) of measured radionuclide leach data from both small- and full-sized samples was performed and indicate that leach data from small samples can be used to determine leachability indexes for full-sizes waste forms. The leachability indexes for cesium, strontium, and cobalt isotopes were determined for waste samples from both plants according to the models used for ANS 16.1. The leachability indexes for the pressurized water reactor samples were 6.4 for cesium, 7.1 for strontium, and 10.4 for cobalt. Leachability indexes for the boiling water reactor samples were 6.5 for cesium, 8.6 for strontium, and 11.1 for cobalt

Fission neutron irradiation of copper containing implanted and transmutation produced helium

DEFF Research Database (Denmark)

Singh, B.N.; Horsewell, A.; Eldrup, Morten Mostgaard

1992-01-01

High purity copper containing approximately 100 appm helium was produced in two ways. In the first, helium was implanted by cyclotron at Harwell at 323 K. In the second method, helium was produced as a transmutation product in 800 MeV proton irradiation at Los Alamos, also at 323 K. The distribut......High purity copper containing approximately 100 appm helium was produced in two ways. In the first, helium was implanted by cyclotron at Harwell at 323 K. In the second method, helium was produced as a transmutation product in 800 MeV proton irradiation at Los Alamos, also at 323 K...... as well as the effect of the presence of other transmutation produced impurity atoms in the 800 MeV proton irradiated copper will be discussed....

Production and dosimetric aspects of the potent Auger emitter {sup 58m}Co for targeted radionuclide therapy of small tumors

Energy Technology Data Exchange (ETDEWEB)

Thisgaard, H.; Elema, D.R.; Jensen, M. [PET and Cyclotron Unit, Nuclear Medicine Department, Odense University Hospital, Sdr. Boulevard 29, DK-5000 Odense, Denmark and Institute of Clinical Research, University of Southern Denmark, Winsloewparken 19, DK-5000 Odense (Denmark); The Hevesy Laboratory, Risoe National Laboratory for Sustainable Energy, Technical University of Denmark, P.O. Box 49, DK-4000 Roskilde (Denmark)

2011-08-15

Purpose: Based on theoretical calculations, the Auger emitter {sup 58m}Co has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state {sup 58g}Co is unfortunately unavoidable, as is ingrowth of the ground state following the isomeric decay of {sup 58m}Co. The impact of {sup 58g}Co as a {beta}{sup +}- and {gamma}-emitting impurity should be included in the dosimetric analysis. The purpose of this study was to investigate this critical part of dosimetry based on experimentally determined production yields of {sup 58m}Co and {sup 58g}Co using a low-energy cyclotron. Also, the cellular S-values for {sup 58m}Co have been calculated and are presented here for the first time. Methods: {sup 58m}Co was produced via the {sup 58}Fe(p,n){sup 58m}Co nuclear reaction on highly enriched {sup 58}Fe metal. In addition, radiochemical separations of produced radio-cobalt from {sup nat}Fe target material were performed. The theoretical subcellular dosimetry calculations for {sup 58m}Co and {sup 58g}Co were performed using the MIRD formalism, and the impact of the increasing ground state impurity on the tumor-to-normal-tissue dose ratios (TND) per disintegration as a function of time after end of bombardment (EOB) was calculated. Results: 192 {+-} 8 MBq of {sup 58m}Co was produced in the irradiation corresponding to a production yield of 10.7 MBq/{mu}Ah. The activity of {sup 58g}Co was measured to be 0.85% {+-} 0.04% of the produced {sup 58m}Co activity at EOB. The radio-cobalt yields in the rapid separations were measured to be >97% with no detectable iron contaminations in the cobalt fractions. Due to the unavoidable coproduction and ingrowth of the long-lived ground state {sup 58g}Co, the TND and the potency of the {sup 58m}Co decrease with time after EOB. If a future treatment with a {sup 58m}Co labeled compound is not initiated before, e.g., 21 h after EOB, the

Suppression of cyclotron instability in Electron Cyclotron Resonance ion sources by two-frequency heating

International Nuclear Information System (INIS)

Skalyga, V.; Izotov, I.; Mansfeld, D.; Kalvas, T.; Koivisto, H.; Komppula, J.; Kronholm, R.; Laulainen, J.; Tarvainen, O.

2015-01-01

Multiple frequency heating is one of the most effective techniques to improve the performance of Electron Cyclotron Resonance (ECR) ion sources. The method increases the beam current and average charge state of the extracted ions and enhances the temporal stability of the ion beams. It is demonstrated in this paper that the stabilizing effect of two-frequency heating is connected with the suppression of electron cyclotron instability. Experimental data show that the interaction between the secondary microwave radiation and the hot electron component of ECR ion source plasmas plays a crucial role in mitigation of the instabilities

Electron cyclotron emission measurements during 28 GHz electron cyclotron resonance heating in Wendelstein WVII-A stellarator

International Nuclear Information System (INIS)

Hartfuss, H.J.; Gasparino, U.; Tutter, M.; Brakel, R.; Cattanei, G.; Dorst, D.; Elsner, A.; Engelhardt, K.; Erckmann, V.; Grieger, G.; Grigull, P.; Hacker, H.; Jaeckel, H.; Jaenicke, R.; Junker, J.; Kick, M.; Kroiss, H.; Kuehner, G.; Maassberg, H.; Mahn, C.; Mueller, G.; Ohlendorf, W.; Rau, F.; Renner, H.; Ringler, H.; Sardei, F.; Weller, A.; Wobig, H.; Wuersching, E.; Zippe, M.; Kasparek, W.; Mueller, G.A.; Raeuchle, E.; Schueller, P.G.; Schwoerer, K.; Thumm, M.

1987-11-01

Electron cyclotron emission measurements have been carried out on electron cyclotron resonance heated plasmas in the WENDELSTEIN VII-A Stellarator. Blackbody radiation from the thermalized plasma main body as well as radiation from a small amount of weakly relativistic suprathermal electrons has been detected. In addition sideband emission has been observed near the second harmonic of the heating line source. Harmonic generation and parametric wave decay at the upper hybrid layer may be a reasonable explanation. (orig.)

radiochemical study on the medically and technology radionuclides of some lanthanides

International Nuclear Information System (INIS)

Aglan, H.A.E.

2010-01-01

In this work, trials for the production of the medically and technologically interesting 139 Ce and 142 Pr radionuclides through cyclotron irradiations using protons and alpha particles were studied. The radiochemical separation of no-carrier-added cerium from proton irradiated lanthanum was studied by solvent extraction using DEE, TBP and TPPO, the latter reagent being employed for the first time for separation of radio cerium from bulk of lanthanum. Distribution coefficients of cerium and lanthanum were investigated as a function of equilibrium time and HNO 3 concentration. A mixture of 0.05 M K 2 Cr 2 O 7 and 0.1 M H 2 SO 4 was used as an oxidizing agent to improve the separation efficiency of cerium. A comparative study of the three extractants released that DEE is the best for separation of cerium from bulk of lanthanum oxide. The target was prepared by pressing. The production of 139 Ce of high radionuclidic and chemical purity via irradiation of lanthanum oxide target at MGC-20 cyclotron with protons of energy 14.5 is described. The experimental yield was found to be 153 kBq/μAh .The adsorption behaviour of La/Ce system on Dowex 50W-X8 in different media, namely, nitric acid, acetate buffer and citrate buffer was studied as a function of the concentration of nitric acid and buffer ph. In addition, in cation-exchange column chromatography experiments, three different eluants, namely, citrate buffer of ph 5.5, 0.1 M EDTA and 0.2 M α-HIBA, were employed for separation of Ce (III) from La (III). The optimum conditions for improvement of radiochemical separation of no-carrier-added 139 Ce from proton irradiated lanthanum were applied using the most suitable chelating agent 0.2 M α-HIBA. The purification of 139 Ce from macro amount of La (III) was done using two columns in a sequence. The experimental yield was found to be 200 kBq/μAh.

Technical meeting of project counterparts on 'Cyclotron production of Iodine-123'. Report

International Nuclear Information System (INIS)

2002-01-01

Several cyclotron laboratory facilities are very much interested in the production of Iodine-123 for medical applications in view of its optimal physical and chemical properties. Some of these countries have in the past used the solid target technology based on utilization of enriched Tellurium targets and are currently involved in the development of enriched Xenon-124 gas targets to improved radionuclidic purity as required by the needs of modern nuclear medicine. With the purpose of discussing the advances in the later route of production and to foster mutual co-operation among the developing countries interested in this technology, a meeting was convened with the participation of scientists from Argentina, Brazil, Iran, Korea and Syria. A scientist from the United States was also invited as an expert to provide advise on particular aspects of the technology. This publication contains as an annex technical reports from the participating institutions. All of these reports have been separately indexed and provided with abstracts

[Cyclotron based nuclear science

International Nuclear Information System (INIS)

1989-06-01

This report contains papers on the following topics: Heavy ion reactors, nuclear structure and fundamental interactions; atomic and materials studies; nuclear theory; and superconducting cyclotron and instrumentation

A new generation of medical cyclotrons for the 90's

International Nuclear Information System (INIS)

Milton, B.F.

1995-08-01

Cyclotrons continue to be efficient accelerators for use in radio-isotope production. In recent years, developments in accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicates a strong future for commercial cyclotrons. In this paper the authors will survey recent developments in the areas of cyclotron technology as they relate to the new generation of commercial cyclotrons. Existing and potential markets for these cyclotrons will be presented. They will also discuss the possibility of systems capable of extracted energies up to 150 MeV and extracted beam currents of up to 2.0 mA

A new generation of medical cyclotrons for the 90's

International Nuclear Information System (INIS)

Milton, B.F.

1995-08-01

Cyclotrons continue to be efficient accelerators for use in radio-isotope production. In recent years, developments in accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicates a strong future for commercial cyclotrons. In this paper we will survey recent developments in the areas of cyclotron technology as they relate to the new generation of commercial cyclotrons. Existing and potential markets for these cyclotrons will be presented. We will also discuss the possibility of systems capable of extracted energies up to 150 MeV and extracted beam currents of up to 2.0 mA. (author)

A small low energy cyclotron for radioisotope measurements

International Nuclear Information System (INIS)

Bertsche, K.J.

1989-11-01

Direct detection of 14 C by accelerator mass spectrometry has proved to be a much more sensitive method for radiocarbon dating than the decay counting method invented earlier by Libby. A small cyclotron (the ''cyclotrino'') was proposed for direct detection of radiocarbon in 1980. This combined the suppression of background through the use of negative ions, which had been used effectively in tandem accelerators, with the high intrinsic mass resolution of a cyclotron. Development of a small electrostatically-focused cyclotron for use as a mass spectrometer was previously reported but the sensitivity needed for detection of 14 C at natural abundance was not achieved. The major contributions of this work are the integration of a high current external ion source with a small flat-field, electrostatically-focused cyclotron to comprise a system capable of measuring 14 C at natural levels, and the analysis of ion motion in such a cyclotron, including a detailed analysis of phase bunching and its effect on mass resolution. A high current cesium sputter negative ion source generates a beam of carbon ions which is pre-separated with a Wien filter and is transported to the cyclotron via a series of electrostatic lenses. Beam is injected radially into the cyclotron using electrostatic deflectors and an electrostatic mirror. Axial focusing is entirely electrostatic. A microchannel plate detector is used with a phase-grated output. In its present form the system is capable of improving the sensitivity of detecting 14 C in some biomedical experiments by a factor of 10 4 . Modifications are discussed which could bring about an additional factor of 100 in sensitivity, which is important for archaeological and geological applications. Possibilities for measurements of other isotopes, such as 3 H, and 10 Be, and 26 Al, are discussed. 70 refs

Atmospheric pressure chemical ionization Fourier transform ion cyclotron resonance mass spectrometry for complex thiophenic mixture analysis

KAUST Repository

Hourani, Nadim; Andersson, Jan T.; Mö ller, Isabelle; Amad, Maan H.; Witt, Matthí as; Sarathy, Mani

2013-01-01

oil (VGO) and injected using the same method. The samples were analyzed using Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS). RESULTS PASH model analytes were successfully ionized and mainly [M + H]+ ions were produced. The same

Radionuclide releases from natural analogues of spent nuclear fuel

International Nuclear Information System (INIS)

Curtis, D.B.; Fabryka-Martin, J.; Dixon, P.; Aguilar, R.; Rokop, D.; Cramer, J.

1993-01-01

Measures of 99 Tc, 129 I, 239 Pu and U concentrations in rock samples from uranium deposits at Cigar Lake and Koongarra have been used to study processes of radionuclide release from uranium minerals. Rates of release have been immeasurably slow at Cigar Lake. At Koongarra release rates appear to have been faster, producing small deficiencies of 99 Tc, and larger ones of 129 I. The inferred differences in radionuclide release rates are consistent with expected differences in uranium mineral degradation rates produced by the differing hydrogeochemical environments at the two sites

U-2g0 cyclotron operational experience and improvement

International Nuclear Information System (INIS)

Gigal, B.N.; Gul'bekyan, G.G.; Kozlov, S.I.; Oganesyan, R.Ts.

1983-01-01

Brief description of main syste's of the U-200 isochronous 2-m cyclotron put into opera ion in 1968 is given and its operational characteristics a e presented. The cyclotron is used for conducting inve tigations in the field of nuclear physics. Ions from d uterium to argon have been accelerated in the cyclotro'. Annual time of target irradiation constitutes 2000-4000. The specific features of the cyclotron are: high l vel of a magnetic field (of about 20 kOe), possibili y of acceleration of ions with different mass-to-charge ratio a low correcting winding power, simple and high-e fective beam extraction by the method of charge exchange on a thin target allowing to vary smoothly energy of extracted ons. An experience in the U-200 cyclotron development and o eration is used as the basis for designing and choosing basic parameters of the U-200P, U-250, U-400 heavy ion cyclotrons

Electron-Cyclotron Waves

NARCIS (Netherlands)

Westerhof, E.

1994-01-01

The essential elements of the theory of electron cyclotron waves are reviewed, The two main electro-magnetic modes of propagation are identified and their dispersion and absorption properties are discussed. The importance of the use of the relativistic resonance condition is stressed.

Development of HM12 cyclotron for PET

International Nuclear Information System (INIS)

Morita, Takuzo; Kawama, Tetsuo; Fujii, Kazuo

2000-01-01

In Japan, there are at present more than 30 PET (Positron Emission Tomography) facilities. The movements of medical insurance application to the PET diagnosis using [ 18 F] FDG (2-[ 18 F]-fluoro-2-deoxy-glucose) by the Ministry of Health and Welfare are being enhanced by PET related people. Therefore, more clinical centers using PET system are expected to be built in the near future. HM12 cyclotron was developed to meet such market demands for PET, and the prototype machine has been rent to Cyclotron Radio Isotope Center (CYRIC) of Tohoku University since Oct. 1998 for their use of clinical research with positron emitters like 11 C, 13 N, 15 O and 18 F. We got many technical data of HM12 Cyclotron on the clinical base. The data was enough to establish the reliability of HM12 system operation under the clinical condition. The first commercial product of HM12 Cyclotron was delivered to National Cancer Center in March 2000. The final performance test will be finished by the end of June 2000. (author)

Lower-hybrid absorption at the ion cyclotron harmonics

International Nuclear Information System (INIS)

Puri, S.

1975-01-01

In the presence of magnetic field gradients, the lower-hybrid wave can be absorbed through linear collisionless damping at the location of cyclotron or cyclotron harmonic resonances acting as singular turning points in the path of the advancing wave-front. (Auth.)

Stability and nonlinear dynamics of gyrotrons at cyclotron harmonics

International Nuclear Information System (INIS)

Saraph, G.P.; Nusinovich, G.S.; Antonsen, T.M. Jr.; Levush, B.

1992-01-01

Gyrotrons operating at higher harmonics of the cyclotron frequency can overcome the frequency limitations caused by achievable strength of the magnetic field. However, the excitation of modes at the fundamental frequency exhibit a major problem for stable operation of harmonic gyrotron at high power with high efficiency. Therefore the issues of stability of gyrotron operation at the cyclotron harmonics and nonlinear dynamics of mode interaction are of great importance. The results of the authors stability analysis and multimode simulation are presented here. A detailed nonlinear theory of steady state single mode operation at cyclotron harmonics has been presented previously, taking into account beam-wave coupling and nonlinear gain function at cyclotron harmonics. A set of equations describing low gain regime interaction of modes resonant at different cyclotron harmonics was studied before. The multifrequency time-dependent nonlinear analysis presented here is based on previous gyrotron studies and beam-wave interaction at cyclotron harmonics. The authors have determined the parameter space for stable single mode operation at the second harmonic. The nonlinear dynamics of mode evolution and mode interaction for a harmonic gyrotron is presented. A new nonlinear effect in which the parasite at the fundamental harmonic helps excite the operating mode at the second harmonic has been demonstrated

A mobile superconducting cyclotron for PET and neutron radiography

International Nuclear Information System (INIS)

Griffiths, R.

1988-01-01

The report addresses the development of a mobile superconducting cyclotron for PET (positron emission tomography) and neutron radiography. Proposals for an ultralight cyclotron were made by Finlan et al., who suggested a novel technique of utilising a superconducting magnet with RF acceleration and iron sectors contained within the room temperature bore of the magnet. Detailed design of a cyclotron based on this concept has progressed well at Oxford Instruments. The main design priorities were to minimise the weight and power consumption of the cyclotron. The cyclotron required a large amount of shielding to reduce either radiation background levels or stray magnetic field. Thus low background levels of radiation and magnetic field are key design criteria. The superconducting magnet has a mean field of 2.35 Tesla and a room temperature bore diameter of 500 mm. Three pairs of profiled iron sectors placed in the center of the warm bore of the magnet provide an azimuthally varying magnetic field. This permits the use of high beam currents with low background. A novel technique is incorporated to reduce the stray magnetic field and radiation from the cyclotron. The RF system consists of three pairs of resonators mounted within the warm bore of the magnet between the iron sectors. (Nogami, K.)

Fabrication of beam diagnostic components for Superconducting Cyclotron at Kolkata

International Nuclear Information System (INIS)

Roy, S.; Bhattacharya, S.; Das, T.; Bhattacharyya, T.K.; Pal, S.; Pal, G.; Mallik, C.; Bhandari, R.K.

2009-01-01

The viewer probe and main probe are used for determining the position and current of charged particles as it is accelerated inside the superconducting cyclotron. The viewer probe is used to visually observe the shape of the charged particle beam inside the cyclotron with the help of a borescope. The main probe measures the distribution of charged particles. The viewer probe and main probe are bellow sealed. They can be positioned with an accuracy of 0.5 mm at different radii within the superconducting cyclotron. M9 slit is placed after the exit flange of the cyclotron. It determines the position of the beam leaving the cyclotron. The beam line has slits, faraday cup, beam viewers, collimators, etc. for beam diagnostics. This paper presents the mechanical design and details of beam diagnostic components. (author)

Neutron radiography by using JSW baby cyclotron

International Nuclear Information System (INIS)

Toda, Yojiro

1995-01-01

At present, JSW baby cyclotrons are mostly used for the production of the radioisotopes for medical use. The attempt to use this baby cyclotron for neutron radiography began already in 1981. The feasibility of the neutron radiography for the explosives in metallic cases which are used for H1 rockets was investigated. In 1983, it was shown that the neutron radiography by using the baby cyclotron in Muroran Works, Japan Steel Works, Ltd. was able to be carried out as a routine work. Since then, the nondestructive inspection by neutron radiography has been performed for rocket pyrotechnic articles, and contributed to heighten their reliability. Further, the radiography by using fast neutrons was developed and put to practical use for recent large H2 rockets. The JSW baby cyclotron BC 168 which has been used for neutron radiography can accelerate 16 MeV protons or 8 MeV deuterons up to 50 μA. The principle of thermal neutron radiography is the generation of fast neutrons by irradiating a Be target with the proton beam accelerated by a baby cyclotron, the moderation of the fast neutrons, the formation of the thermal neutron flux of uniform distribution with a collimator, the thermal neutron flux hitting the Gd plate in a film cassette through an object, and the exposure of an X-ray film to electrons from the Gd plate. Fast neutron radiography apparatus, and commercial neutron radiography are described. (K.I.)

Natural radionuclides in the human body; Natuerliche Radionuklide im menschlichen Koerper

Energy Technology Data Exchange (ETDEWEB)

Voelkle, Hansruedi [Fribourg Univ. (Switzerland). Physikdept.

2017-08-01

Natural radionuclides in the human body produce worldwide a medium annual radiation exposure of 0.31 mSv. 0.17 mSv are due to potassium-40 (K-40) per year, 0.12 mSv per year are due to radionuclides from the uranium and thorium decay series, less than 0.02 mSv due to cosmogenic radionuclides. Natural radioactivity is therefore the largest exposure source, anthropogenic exposure is comparatively marginal.

Symposium on nuclear particle accelerators in medicine: abstracts

International Nuclear Information System (INIS)

1986-01-01

This symposium deals with the cyclotron production of radiopharmaceuticals and the application of radionuclides and -pharmaceuticals produced this way. The use of positron emitters in nuclear medicine medical physics and radiobiology are discussed as well as radiotherapy and all the aspects of neutron radiation and dosimetry of neutron therapy

Cyclotron beam dynamic simulations in MATLAB

International Nuclear Information System (INIS)

Karamysheva, G.A.; Karamyshev, O.V.; Lepkina, O.E.

2008-01-01

MATLAB is useful for beam dynamic simulations in cyclotrons. Programming in an easy-to-use environment permits creation of models in a short space of time. Advanced graphical tools of MATLAB give good visualization features to created models. The beam dynamic modeling results with an example of two different cyclotron designs are presented. Programming with MATLAB opens wide possibilities of the development of the complex program, able to perform complete block of calculations for the design of the accelerators

Radionuclide diagnostics in St. Petersburg: сurrent status and development challenges

Directory of Open Access Journals (Sweden)

I. A. Zvonova

2015-01-01

healthcare centers for in vivo diagnostics were using 24 radiofarmaceuticals, traced 99mTc, 123I, 131I, 67Ga, for PET – diagnostics – radiofarmaceuticals with cyclotron radionuclides 18F, 11C, 13N, 15O. 60–70% are traced 99mTc. Over 10 years the radiodiagnostics structure has changed towards increased number of scintigraphic studies and reduction of “functional” (radiometric procedures which reflects the changes in the equipment of the radionuclide diagnostics units, the replacement of the old equipment by new SPECT.         The mean effective dose per one radiodiagnostic test in St. Petersburg is 2.4 mSv. Scintigraphic tests’ mean exposure doses are between 0.9 mSv and 7 mSv. Patients are exposed to the highest doses during whole body diagnostics with administration of 67Ga- citrate and 123I – sodium iodide (about 20 mSv and above. During heart and brain diagnolstics patient’s exposure dose averages 4 mSv. Radiometric (functional tests’ exposure doses are 0.1 – 0.3 mSv.Conclusion. Since 2013 the amount of radionuclide diagnostic tests has increased.The main objective is to modernize the radionuclide diagnostics equipment in the city. After replacement of the old equipment by the state-of-the art one in most probability high- dose diagnostics will increase in number which will result in increased radionuclide diagnostics contribution into population medical exposure dose. Statistical observation form of patients’ medical exposure doses 3 – DOZ requires modernization in the part of radionuclide diagnostics in compliance with advancement in this medical sphere.  

Magnet design and test of positron emission tomography cyclotron

International Nuclear Information System (INIS)

Wei Tao; Yang Guojun; He Xiaozhong; Pang Jian; Zhao Liangchao; Zhang Kaizhi

2012-01-01

An 11 MeV H - compact cyclotron used for medical radioactive isotope production is under construction in Institute of Fluid Physics, CAEP. The cyclotron magnet adopts the design of small valley gaps and coulee structure which can provide high average magnetic field and strong focus ability. To achieve 5 × 10 -4 measuring accuracy, a magnetic field mapping system has been developed. After iterative correction using field measurement data, the total phase excursion of the cyclotron is within ± 9° and the first harmonic is less than 10 -3 T, which are all acceptable. Furthermore, the beam testing declares the successful construction of the cyclotron magnet. Besides, some magnetic field influence factors were discussed, including the magnetic field distortion and measurement error. (authors)

Studies of electron cyclotron emission on text

International Nuclear Information System (INIS)

Gandy, R.F.

1990-07-01

The Auburn University electron cyclotron emission (ECE) system has made many significant contributions to the TEXT experimental program during the past five years. Contributions include electron temperature information used in the following areas of study: electron cyclotron heating (ECH), pellet injection, and impurity/energy transport. Details of the role which the Auburn ECE system has played will now be discussed

Cyclotrons for the production of radioactive beams

International Nuclear Information System (INIS)

Clark, D.J.

1990-01-01

This paper describes the characteristics and design choices for modern cyclotrons. Cyclotrons can be used in 3 areas in the radioactive beam field: the production of high energy heavy ion beams for use in fragmentation, the spallation of targets with high energy protons, and the acceleration of radioactive beams from low energy to the MeV/u range. 16 refs., 6 figs

Wave fronts of electromagnetic cyclotron harmonic waves

International Nuclear Information System (INIS)

Ohnuma, T.; Watanabe, T.

1982-01-01

In an inhomogeneous high-density magnetized plasma, the spatial properties of the wave fronts and ray trajectories of electromagnetic ordinary and extraordinary cyclotron harmonic waves are investigated. Those waves which are radiated from a local source are found to have wave fronts which are almost parallel to the magnetic field. Also, the reflective properties of the electromagnetic cyclotron harmonic waves are confirmed

Investigation of radiopharmaceuticals from cyclotron produced radionuclides and development of mathematical models. Part of a coordinated programme on production of radiopharmaceuticals from accelerator-produced isotopes

International Nuclear Information System (INIS)

Slaus, I.

1983-04-01

Several radioisotopes for diagnostic uses in nuclear medicine studies are produced using the internal 15 MeV (30 MeV alphas) deuteron beam of the ''Ruder Boskovic'' Institute in Zagreb, Yugoslavia. Some of the most important radioisotopes produced during the last few years are: Gallium-67 (d, xn reaction on a Cu/Ni/Zn target) with yield of 7.6 MBq/uAh, 81 Rb-sup(81m)Kr generator (α, 2n reaction on a Cu/Cu 2 Br 2 target) with a yield of 99 MBq/uAh, Iodine-123 (α, 2n reaction on a Cu/Ag/Sb target) with a yield of 6.3 MBq/uAh, and Indium-111 (α, 2n reaction on a Cu/Cu/Ag target) with a yield of 7.2 MBq/uAh. In addition, a simple mathematical lung model for regional ventilation measurements was developed and used for ventilation studies on normal subjects and subjects with various lung diseases. Based on these studies, a more sophisticated and quantitative lung ventilation model for radioactive tracer tidal breathing was further developed. In this new model, the periodicity of breathing is completely taken into account, and it makes possible to actually determine lung ventilation and volume parameters. The model is experimentally verified on healthy subjects, and the value of the effective specific ventilation obtained is in agreement with comparable parameters in the literature. sup(81m)Kr from a generator was used to perform these experimental studies

Radionuclide toxicity

International Nuclear Information System (INIS)

Galle, P.

1982-01-01

The aim of this symposium was to review the radionuclide toxicity problems. Five topics were discussed: (1) natural and artificial radionuclides (origin, presence or emission in the environment, human irradiation); (2) environmental behaviour of radionuclides and transfer to man; (3) metabolism and toxicity of radionuclides (radioiodine, strontium, rare gas released from nuclear power plants, ruthenium-activation metals, rare earths, tritium, carbon 14, plutonium, americium, curium and einsteinium, neptunium, californium, uranium) cancerogenous effects of radon 222 and of its danghter products; (4) comparison of the hazards of various types of energy; (5) human epidemiology of radionuclide toxicity (bone cancer induction by radium, lung cancer induction by radon daughter products, liver cancer and leukaemia following the use of Thorotrast, thyroid cancer; other site of cancer induction by radionuclides) [fr

Estimation of exposure quantity of gamma and neutron in 13 MeV proton cyclotron for radioisotope production of 18F

International Nuclear Information System (INIS)

Sunardi; Silakhuddin

2015-01-01

Quantitative estimation of gamma and neutron exposure in 13 MeV proton cyclotron for radioisotope of 18 F has been done. The aim of this study is to know the exposure of gamma and neutron that will be generated by 13 MeV proton cyclotron The method that was used is the determine of gamma and neutron quantity exposure that produced by proton beam collision with matter in the cyclotron chamber and cyclotron target. The analysis result showed that the reactions occur at chamber are 63 Cu(p,n) 63 Zn, 65 Cu(p,n) 65 Zn and 56 Fe(p,n) 56 Co,, while at the target is 18 O(p,n) 18 F. The calculation result of neutron flux at the chamber and the target facility are 7,34×10 7 n/cm 2 dt and 1.10×10 9 n/cm 2 dt, respectively. The gamma activity at the chamber for reaction 63 Cu(p,n) 63 Zn, 65 Cu(p,n) 65 Zn and 56 Fe(p,n) 56 Co are 3,0×10 8 Bq, 4,54×10 5 Bq and 1,13×10 9 Bq respectively, while the gamma activity at the cyclotron target is 1,84×10 8 Bq. The data can be used as a basis for designing the cyclotron radiation shielding. (author)

Separation of radionuclides from water by magnesium oxide adsorption

International Nuclear Information System (INIS)

Tseng, Chia-Lian; Lo, Jem-Mau; Yeh, Si-Jung

1987-01-01

Adsorption by magnesium oxide of more than forty radionuclides in respective ionic species in water was observed. Generally, the radionuclides in di-valent and/or multi-valent cations are favorably adsorbed by magnesium oxide; but not for the those in mono-valent cations. In addition, the adsorption by magnesium oxide was not effective to most of the radionuclides in negative ionic species. From the observations, the adsorption mechanism is more prominently by the ion exchange of the di- or multi-valent cation species with the hydrous magnesium oxide. Separation of the radionuclides related to the corrosion products possibly produced in a nuclear power plant from natural seawater was attempted by the magnesium oxide adsorption method. It should be emphasized that the adsorption method was found to be practical for separating radionuclides from a large quantity of natural seawater with high recovery and high reproducibility. (author)

Intensity limits of the PSI Injector II cyclotron

Science.gov (United States)

Kolano, A.; Adelmann, A.; Barlow, R.; Baumgarten, C.

2018-03-01

We investigate limits on the current of the PSI Injector II high intensity separate-sector isochronous cyclotron, in its present configuration and after a proposed upgrade. Accelerator Driven Subcritical Reactors, neutron and neutrino experiments, and medical isotope production all benefit from increases in current, even at the ∼ 10% level: the PSI cyclotrons provide relevant experience. As space charge dominates at low beam energy, the injector is critical. Understanding space charge effects and halo formation through detailed numerical modelling gives clues on how to maximise the extracted current. Simulation of a space-charge dominated low energy high intensity (9.5 mA DC) machine, with a complex collimator set up in the central region shaping the bunch, is not trivial. We use the OPAL code, a tool for charged-particle optics calculations in large accelerator structures and beam lines, including 3D space charge. We have a precise model of the present (production) Injector II, operating at 2.2 mA current. A simple model of the proposed future (upgraded) configuration of the cyclotron is also investigated. We estimate intensity limits based on the developed models, supported by fitted scaling laws and measurements. We have been able to perform more detailed analysis of the bunch parameters and halo development than any previous study. Optimisation techniques enable better matching of the simulation set-up with Injector II parameters and measurements. We show that in the production configuration the beam current scales to the power of three with the beam size. However, at higher intensities, 4th power scaling is a better fit, setting the limit of approximately 3 mA. Currents of over 5 mA, higher than have been achieved to date, can be produced if the collimation scheme is adjusted.

Status report on the cyclotron

International Nuclear Information System (INIS)

Kormany, Z.

2002-01-01

Complete text of publication follows. The operation of the cyclotron in 2001 was again concentrated to the usual 9 months; January, July and August were reserved for maintenance and holidays. The overall working time of the accelerator was 4300 hours, the breakdown periods amounted to 66 hours last year. The cyclotron was available for users during 3751 hours, the effectively used beam-on-target time is summarized in Table 1. The total time required for machine setup and beam tuning or spent waiting for the start of an irradiation was 272 hours. The control of the adjustable collimators applied in the beam transport system of the cyclotron was renewed during the winter maintenance period. They have been connected to the programmable logic controllers (PLC) and their new control code frees the operators from the long and slow manual setting process. The successful renewal of the control of this and other subsystems (cyclotron and beam transport power supplies) made lots of adjusting and measuring elements on the original control desk needless. To provide more space for the control PCs and remove all unnecessary devices, the unused part of the control desk has been dismantled. The short beam line used mainly for radiation hardness studies was equipped with a new oil-diffusion vacuum system during the summer maintenance. Its components are also connected to the PLC and the same automatic control has been provided like for the other vacuum stands of- the beam transport system. Another short beam line - basically a mirror image of the first one - has also been installed and successfully tested by trial irradiations. (R.P.)

Statistical fluctuations in cooperative cyclotron radiation

Science.gov (United States)

Anishchenko, S. V.; Baryshevsky, V. G.

2018-01-01

Shot noise is the cause of statistical fluctuations in cooperative cyclotron radiation generated by an ensemble of electrons oscillating in magnetic field. Autophasing time - the time required for the cooperative cyclotron radiation power to peak - is the critical parameter characterizing the dynamics of electron-oscillators interacting via the radiation field. It is shown that premodulation of charged particles leads to a considerable narrowing of the autophasing time distribution function for which the analytic expression is obtained. When the number of particles Ne exceeds a certain value that depends on the degree to which the particles have been premodulated, the relative root-mean-square deviation (RMSD) of the autophasing time δT changes from a logarithmic dependence on Ne (δT ∼ 1 / lnNe) to square-root (δT ∼ 1 /√{Ne }). A slight energy spread (∼4%) results in a twofold drop of the maximum attainable power of cooperative cyclotron radiation.

Decommissioning analyzis of a university cyclotron

International Nuclear Information System (INIS)

Eggermont, G.X.; Buls, N.; Hermanne, A.

1996-01-01

In the widespread use of some medical nuclear facilities, such as cyclotrons for isotope production, Life cycle analyzis, including decommissioning, was not taken into account. The structural materials of an accelerator and the concrete shielding of the bunker are activated by neutrons. This could yield a considerable volume of nuclear waste and needs radiation protection concern for occupational workers and the environment during some decennia. At the university of Brussels (WB) a prospective radiation protection and waste analyzis is being made for the later decommissioning of their cyclotron. Only few similar studies have been published. In Belgium future nuclear dismantling operations will be submitted to a radiation protection authorization procedure. Meanwhile the nuclear waste authorities insist on dismantling planning, including financial provisioning. An optimization exercise was made at the VUB-cyclotron, taking into account international trends to clearance levels for low level nuclear waste. Conceptual prevention opportunities e.g. selective material choice could be identified for future accelerator constructions. (author)

Cyclotron resonance cooling by strong laser field

International Nuclear Information System (INIS)

Tagcuhi, Toshihiro; Mima, Kunioka

1995-01-01

Reduction of energy spread of electron beam is very important to increase a total output radiation power in free electron lasers. Although several cooling systems of particle beams such as a stochastic cooling are successfully operated in the accelerator physics, these cooling mechanisms are very slow and they are only applicable to high energy charged particle beams of ring accelerators. We propose here a new concept of laser cooling system by means of cyclotron resonance. Electrons being in cyclotron motion under a strong magnetic field can resonate with circular polarized electromagnetic field, and the resonance take place selectively depending on the velocity of the electrons. If cyclotron frequency of electrons is equal to the frequency of the electromagnetic field, they absorb the electromagnetic field energy strongly, but the other electrons remain unchanged. The absorbed energy will be converted to transverse kinetic energy, and the energy will be dumped into the radiation energy through bremastrahlung. To build a cooling system, we must use two laser beams, where one of them is counter-propagating and the other is co-propagating with electron beam. When the frequency of the counter-propagating laser is tuned with the cyclotron frequency of fast electrons and the co-propagating laser is tuned with the cyclotron frequency of slow electrons, the energy of two groups will approach and the cooling will be achieved. We solve relativistic motions of electrons with relativistic radiation dumping force, and estimate the cooling rate of this mechanism. We will report optimum parameters for the electron beam cooling system for free electron lasers

Ion source and injection line for high intensity medical cyclotron

Science.gov (United States)

Jia, XianLu; Guan, Fengping; Yao, Hongjuan; Zhang, TianJue; Yang, Jianjun; Song, Guofang; Ge, Tao; Qin, Jiuchang

2014-02-01

A 14 MeV high intensity compact cyclotron, CYCIAE-14, was built at China Institute of Atomic Energy (CIAE). An injection system based on the external H- ion source was used on CYCIAE-14 so as to provide high intensity beam, while most positron emission tomography cyclotrons adopt internal ion source. A beam intensity of 100 μA/14 MeV was extracted from the cyclotron with a small multi-cusp H- ion source (CIAE-CH-I type) and a short injection line, which the H- ion source of 3 mA/25 keV H- beam with emittance of 0.3π mm mrad and the injection line of with only 1.2 m from the extraction of ion source to the medial plane of the cyclotron. To increase the extracted beam intensity of the cyclotron, a new ion source (CIAE-CH-II type) of 9.1 mA was used, with maximum of 500 μA was achieved from the cyclotron. The design and test results of the ion source and injection line optimized for high intensity acceleration will be given in this paper.

Cyclotron will not survive yet this year without state support

International Nuclear Information System (INIS)

Marcan, P.

2005-01-01

In this paper the project of the Cyclotron Center of the Slovak republic is described. On the basis of this project the state joint-stock company Biont was constituted. Small cyclotron is in operation; big cyclotron is in process of manufacture and it will be put in operation in 2007. Small cyclotron will be used for production of radiopharmaceuticals. Positron emission tomograph (PET) in Oncological Institute of St. Elizabeth (in Bratislava) and gamma camera in Central Military Hospital (in Ruzomberok) are constituents of the Biont. The PET will be also in Biont. The hadron therapy of ophthalmic tumors is planned. Financial plans of the Biont up to 2009 are presented

The problems of high efficient extraction from the isochronous cyclotron

International Nuclear Information System (INIS)

Schwabe, J.

1994-06-01

The problem of high efficient extraction (η ≥ 50%) from isochronous cyclotrons (with the exception of the stripping method) is not completely solved up to this day. This problem is specifically important, because these cyclotrons are being also applied in the production of medical radioisotopes, labeled pharmaceuticals as well as in neutron therapy (oncology), machine industry, agriculture (plant mutagenesis), etc. The aim of the proposed topic is to solve this problem on the AIC-144 isochronous cyclotron in the INP (Institute of Nuclear Physics). Lately, a beam of 20 MeV deuterons with an efficiency of ca. 15% was extracted from this cyclotron. (author). 25 refs, 14 figs

Microbial transformations of natural organic compounds and radionuclides in subsurface environments

International Nuclear Information System (INIS)

Francis, A.J.

1985-10-01

A major national concern in the subsurface disposal of energy wastes is the contamination of ground and surface waters by waste leachates containing radionuclides, toxic metals, and organic compounds. Microorganisms play an important role in the transformation of organic compounds, radionuclides, and toxic metals present in the waste and affect their mobility in subsurface environments. Microbial processes involved in dissolution, mobilization, and immobilization of toxic metals under aerobic and anaerobic conditions are briefly reviewed. Metal complexing agents and several organic acids produced by microbial action affect mobilization of radionuclides and toxic metals in subsurface environments. Information on the persistence of and biodegradation rates of synthetic as well as microbiologically produced complexing agents is scarce but important in determining the mobility of metal organic complexes in subsoils. Several gaps in knowledge in the area of microbial transformation of naturally occurring organics, radionuclides, and toxic metals have been identified, and further basic research has been suggested. 31 refs., 1 fig., 3 tabs

Thermal Stabilization of Cryogenic System in Superconducting Cyclotron

International Nuclear Information System (INIS)

Shin, Seung Jae; Kim, Kyung Min; Cho, Hyung Hee; Hong, Bong Hwan; Kang, Joon Sun; Ahn, Dong Hyun

2011-01-01

Radiology has some useful applications for medical purpose. For cancer therapy, the superconducting cyclotron should generate heavy ion beams. It radiates heavy ion beams to cancer patients. In order to make cyclotron system stable, the cryogenic system which makes superconducting state should work constantly. However, radiation heat transfer of cryogenic system should be considered because liquid helium's boiling point is extremely low and there is huge temperature difference between the cryogenic system and ambient temperature. Accordingly, thermal analysis should be carried out. In this paper, the numerical analysis of the cryogenic system in practical superconducting cyclotron show temperature distribution and suggest the number of coolers using ANSYS Workbench program

Methods of separating short half-life radionuclides from a mixture of radionuclides

International Nuclear Information System (INIS)

Bray, L.A.; Ryan, J.L.

1998-01-01

The present invention is a method of obtaining a radionuclide product selected from the group consisting of 223 Ra and 225 Ac, from a radionuclide ''cow'' of 227 Ac or 229 Th respectively. The method comprises the steps of (a) permitting ingrowth of at least one radionuclide daughter from said radionuclide ''cow'' forming an ingrown mixture; (b) insuring that the ingrown mixture is a nitric acid ingrown mixture; (c) passing the nitric acid ingrown mixture through a first nitrate form ion exchange column which permits separating the ''cow'' from at least one radionuclide daughter; (d) insuring that the at least one radionuclide daughter contains the radionuclide product; (e) passing the at least one radionuclide daughter through a second ion exchange column and separating the at least one radionuclide daughter from the radionuclide product and (f) recycling the at least one radionuclide daughter by adding it to the ''cow''. In one embodiment the radionuclide ''cow'' is the 227 Ac, the at least one daughter radionuclide is a 227 Th and the product radionuclide is the 223 Ra and the first nitrate form ion exchange column passes the 227 Ac and retains the 227 Th. In another embodiment the radionuclide ''cow'' is the 229 Th, the at least one daughter radionuclide is a 225 Ra and said product radionuclide is the 225 Ac and the 225 Ac and nitrate form ion exchange column retains the 229 Th and passes the 225 Ra/Ac. 8 figs

A radioisotope production cyclotron designed to minimize dose

International Nuclear Information System (INIS)

Szlavik, F.F.; Moritz, L.E.

1992-01-01

This paper describes a radioisotope production cyclotron which has been designed to minimize the dose to personnel during operation and maintenance. The design incorporates lessons learned from the operation of a CP42 cyclotron and has resulted in a reduction of the dose by a factor of more than 10. (author)

Cyclotron based nuclear science. Progress report, April 1, 1985-March 31, 1986

International Nuclear Information System (INIS)

Youngblood, D.H.

1986-08-01

Progress report for cyclotron based nuclear science cyclotron facility are summarized. Research is described under the headings heavy ion reactions, nuclear theory, atomic studies and activation analysis, superconducting cyclotron and instrumentation. Publications are listed

Health physics aspects of the 1.5M cyclotron

International Nuclear Information System (INIS)

Song, W.J.; Du, H.L.; Wei, Z.Q.; Xia, X.S.; Zheng, H.Z.; Jiang, G.F.; Liu, Y.Y.

1987-01-01

The 1.5m cyclotron in Institute of Modern Physics, Academia Sinica had operated for about 20 years until 1984 then converted to 1.7m sector focusing cyclotron. In this period it mainly used for fast neutron physics, light ion induced nucleus reactions, radioisotope production and heavy ion reactions. The health physics performed on this cyclotron including personnel dose monitoring, area monitoring (radiation field, radioactive aerosol, surface contamination and activated components etc.), maintenance inspection, environment survey and waste disposal is presented in this paper

Model of charge-state distributions for electron cyclotron resonance ion source plasmas

Directory of Open Access Journals (Sweden)

D. H. Edgell

1999-12-01

Full Text Available A computer model for the ion charge-state distribution (CSD in an electron cyclotron resonance ion source (ECRIS plasma is presented that incorporates non-Maxwellian distribution functions, multiple atomic species, and ion confinement due to the ambipolar potential well that arises from confinement of the electron cyclotron resonance (ECR heated electrons. Atomic processes incorporated into the model include multiple ionization and multiple charge exchange with rate coefficients calculated for non-Maxwellian electron distributions. The electron distribution function is calculated using a Fokker-Planck code with an ECR heating term. This eliminates the electron temperature as an arbitrary user input. The model produces results that are a good match to CSD data from the ANL-ECRII ECRIS. Extending the model to 1D axial will also allow the model to determine the plasma and electrostatic potential profiles, further eliminating arbitrary user input to the model.

Electromagnetic Ion Cyclotron Waves in the Helium Branch Induced by Multiple Electromagnetic Ion Cyclotron Triggered Emissions

Science.gov (United States)

Shoji, M.; Omura, Y.; Grison, B.; Pickett, J. S.; Dandouras, I. S.; Engebretson, M. J.

2011-12-01

Electromagnetic ion cyclotron (EMIC) triggered emissions with rising tones between the H+ and He+ cyclotron frequencies were found in the inner magnetosphere by the recent Cluster observations. Another type of EMIC wave with a constant frequency is occasionally observed below the He+ cyclotron frequency after the multiple EMIC triggered emissions. We performed a self-consistent hybrid simulation with a one-dimensional cylindrical magnetic flux model approximating the dipole magnetic field of the Earth's inner magnetosphere. In the presence of energetic protons with a sufficient density and temperature anisotropy, multiple EMIC triggered emissions are reproduced due to the nonlinear wave growth mechanism of rising-tone chorus emissions, and a constant frequency wave in the He+ EMIC branch is subsequently generated. Through interaction with the multiple EMIC rising-tone emissions, the velocity distribution function of the energetic protons is strongly modified. Because of the pitch angle scattering of the protons, the gradient of the distribution in velocity phase space is enhanced along the diffusion curve of the He+ branch wave, resulting in the linear growth of the EMIC wave in the He+ branch.

Fabrication of miniature magnetic magnet pole for validate simulation of magnetic cyclotron proton 13 MeV

International Nuclear Information System (INIS)

Subroto; Sukiya; Tony R

2013-01-01

A fabrication of miniature magnetic pole field has been made to validate the simulation system 13 MeV magnet of proton cyclotron using mild steel material. This electromagnet of magnetic pole at the end of the magnetic pole is divided into 8 parts of the valley and the hill interval to produce different magnetic field. Pole magnetic field fabrication is meet to match the design of the system simulation results 13 MeV cyclotron magnet. This requires strong cyclotron magnetic field average at 1.275 T magnetic field strength of each piece was different. So that the ion beam passing through a magnetic field. Will be focused before mashing target. The surface of magnetic pole is circular with a diameter of 100 mm and 32 mm pole spacing. Miniature of electrical pole diameter is only one-tenth the diameter of 960 mm designed this requires current 10 A with voltage 30 V to produce field strength of 0.3 T. To measure the magnetic field strength tesla meter is used and to measure the relationship curve in pole position with a magnetic field strength magnets cylinder directions X and Y the used mini lathe. Field strength measurement results with a straight, oblique and circular position show nearly equal to curve simulation results using a 3D module TOSCA opera program. (author)

Production, administration and disposal of cyclotron produced shortlived radioactive gases for positron emission tomography studies at the Austin Repatriation Medical Centre, Melbourne

Energy Technology Data Exchange (ETDEWEB)

Egan, G.F.; O`Keefe, G. [Austin Hospital, Heidelberg, VIC (Australia); Tochon-Danguy, H.J.; Midgley, S.; Phana, K.S.; Sachinidis, J.; Chan, J.G. [Melbourne Univ., Parkville, VIC (Australia). School of Physics

1995-01-01

Positron Emission Tomography (PET) Centre is operational at the Austin Repatriation Medical Centre, Melbourne. The major equipment consists of a 10 MeV cyclotron and a whole body PET scanner. Radioactive gases produced and used directly in clinical studies include [{sup 15}O]O{sub 2}, [{sup 15}O]CO, and [{sup 15}O]CO{sub 2}, whilst [{sup 11}C]CO{sub 2} is also produced for use in radiochemistry syntheses. Radioactivity delivery rates of 3.7, 3.3, and 1.6 GBq/min to the scanner suite have been achieved for [{sup 15}O]O{sub 2}, [{sup 15}O]CO{sub 2}, and [{sup 15}O]CO respectively, and batch productions of 36.3 GBq of [{sup 11}C]CO{sub 2} have been produced. The production. patient administration and disposal of the short-lived radioactive gases has been achieved in compliance with radiation protection principles. Radioactive gas doses of 1.7 GBq are administered to patients with less than 0.02 MBq/m{sup 3} leakage into the scanner suite. Less than 13 MBq of [ {sup 15}O]-labelled gases are released into the environment per patient study at a concentration of 0.018 MBq/m{sup 3}. Annually less than 2 GBq is expected to be released into the environment. The centre design and first four months` experience of radioactive gas production, administration and disposal is presented. 5 refs., 4 tab., 1 fig.

A simple thick target for production of ⁸⁹Zr using an ¹¹MeV cyclotron

Energy Technology Data Exchange (ETDEWEB)

Link, Jeanne M.; Krohn, Kenneth A.; O' Hara, Matthew J.

2017-04-01

The growing interest but limited availability of ⁸⁹Zr for PET led us to test targets for the ⁸⁹(p,n) reaction. The goal was an easily constructed target for an 11 MeV Siements cyclotron. Yttrium foils were tested at different thicknesses, angles and currents. A 90 degree foil tolerated 41 microAmp without damage and produced ~800 MBq/hr, >20 mCi, an amount adequate for radiochemistry research and human doses in a widely available accelerator. This method should translate to higher energy cyclotrons.

Radionuclides incorporation in activated natural nanotubes

International Nuclear Information System (INIS)

Silva, Jose Parra

2016-01-01

Natural palygorskite nanotubes show suitable physical and chemical properties and characteristics to be use as potential nanosorbent and immobilization matrix for the concentration and solidification of radionuclides present in nuclear wastes. In the development process of materials with sorption properties for the incorporation and subsequent immobilization of radionuclides, the most important steps are related with the generation of active sites simultaneously to the increase of the specific surface area and suitable heat treatment to producing the structural folding. This study evaluated the determining parameters and conditions for the activation process of the natural palygorskite nanotubes aiming at the sorption of radionuclides in the nanotubes structure and subsequent evaluation of the parameters involve in the structural folding by heat treatments. The optimized results about the maximum sorption capacity of nickel in activated natural nanotubes show that these structures are apt and suitable for incorporation of radionuclides similar to nickel. By this study is verified that the optimization of the acid activation process is fundamental to improve the sorption capacities for specifics radionuclides by activated natural nanotubes. Acid activation condition optimized maintaining structural integrity was able to remove around 33.3 wt.% of magnesium cations, equivalent to 6.30·10 -4 g·mol -1 , increasing in 42.8% the specific surface area and incorporating the same molar concentration of nickel present in the liquid radioactive waste at 80 min. (author)

A 30 MeV H- cyclotron for isotope production

International Nuclear Information System (INIS)

Milton, B.F.; Dawson, R.; Erdman, K.L.

1989-05-01

Because of an expanding market for radioisotopes there is a need for a new generation of cyclotrons designed specifically for this purpose. TRIUMF is cooperating with a local industrial company in designing and constructing such a cyclotron. It will be a four sector H - cyclotron, exploiting the newly developed high brightness multicusp ion source. This source with H - current capability in excess of 5 mA makes feasible accelerated H - beam intensities of up to 500 μA. Beam extraction is by stripping to H + in a thin graphite foil. Extraction of two high-intensity beams, with energy variable from 15 to 30 MeV is planned. The use of an external ion source, provision of a good vacuum in the acceleration region, and the careful choice of materials for components in the median plane leads to a cyclotron that will have low activation and can be easily serviced in spite of the very high operating beam intensities. A design extension to 70 MeV using many of the design features of the 30 MeV cyclotron can be easily made. Such a machine with a good quality variable energy beam is a highly desirable source of protons for isotope production, injection into higher energy high intensity acceleration, injection into higher energy high intensity accelerators, and as an irradiation facility for ocular melanomas. Design of the 30 MeV cyclotron is well advanced and construction is in progress

Underground radionuclide migration at the Nevada Test Site

International Nuclear Information System (INIS)

Nimz, G.J.; Thompson, J.L.

1992-01-01

This document reviews results from a number of studies concerning underground migration of radionuclides from nuclear test cavities at the Nevada Test Site (NTS). Discussed are all cases known to the Department of Energy's Hydrology and Radionuclide Migration Program where radionuclides have been detected outside of the immediate vicinity of nuclear test cavities that are identifiable as the-source of the nuclides, as well as cases where radionuclides might have been expected and were intentionally sought but not fixed. There are nine locations where source-identifiable radionuclide migration has been detected, one where migration was purposely induced by pumping, and three where migration might be expected but was not found. In five of the nine cases of non-induced migration, the inferred migration mechanism is prompt fracture injection during detonation. In the other four cases, the inferred migration mechanism is water movement. In only a few of the reviewed cases can the actual migration mechanism be stated with confidence, and the attempt has been made to indicate the level of confidence for each case. References are cited where more information may be obtained. As an aid to future study, this document concludes with a brief discussion of the aspects of radionuclide migration that, as the present review indicates, are not yet understood. A course of action is suggested that would produce a better understanding of the phenomenon of radionuclide migration

Calculation of particle dynamics in CI-10 cyclotron

International Nuclear Information System (INIS)

Samsonov, E.V.; Karamysheva, G.A.; Vorozhtsov, S.B.

1999-01-01

The calculations of beam dynamic characteristics of High-Intensity Cyclotron-Injector CI-10 for deuteron beam of 15 MeV energy are presented. Analytical estimations of space charge effects are given. In order to increase the intensity of the accelerator beam some ideas about the cyclotron design modification are given too. (author)

Methods of separating short half-life radionuclides from a mixture of radionuclides

Science.gov (United States)

Bray, Lane A.; Ryan, Jack L.

1998-01-01

The present invention is a method of obtaining a radionuclide product selected from the group consisting of .sup.223 Ra and .sup.225 Ac, from a radionuclide "cow" of .sup.227 Ac or .sup.229 Th respectively. The method comprises the steps of a) permitting ingrowth of at least one radionuclide daughter from said radionuclide "cow" forming an ingrown mixture; b) insuring that the ingrown mixture is a nitric acid ingrown mixture; c) passing the nitric acid ingrown mixture through a first nitrate form ion exchange column which permits separating the "cow" from at least one radionuclide daughter; d) insuring that the at least one radionuclide daughter contains the radionuclide product; e) passing the at least one radionuclide daughter through a second ion exchange column and separating the at least one radionuclide daughter from the radionuclide product and f) recycling the at least one radionuclide daughter by adding it to the "cow". In one embodiment the radionuclide "cow" is the .sup.227 Ac, the at least one daughter radionuclide is a .sup.227 Th and the product radionuclide is the .sup.223 Ra and the first nitrate form ion exchange column passes the .sup.227 Ac and retains the .sup.227 Th. In another embodiment the radionuclide "cow"is the .sup.229 Th, the at least one daughter radionuclide is a .sup.225 Ra and said product radionuclide is the .sup.225 Ac and the .sup.225 Ac and nitrate form ion exchange column retains the .sup.229 Th and passes the .sup.225 Ra/Ac.

Design of RF system for CYCIAE-230 superconducting cyclotron

Energy Technology Data Exchange (ETDEWEB)

Yin, Zhiguo, E-mail: bitbearAT@hotmail.com; Ji, Bin; Fu, Xiaoliang; Cao, Xuelong; Zhao, Zhenlu; Zhang, Tinajue

2017-05-11

The CYCIAE230 is a low-current, compact superconducting cyclotron designed for proton therapy. The Radio Frequency system consists of four RF cavities and applies second harmonic to accelerate beams. The driving power for the cavity system is estimated to be approximately 150 kW. The LLRF controller is a self-made device developed and tested at low power using a small-scale cavity model. In this paper, the resonator systems of an S.C. cyclotron in history are reviewed. Contrary to those RF systems, the cavities of the CYCIAE230 cyclotron connect two opposite dees. Two high-power RF windows are included in the system. Each window carries approximately 75 kW RF power from the driver to the cavities. Thus, the RF system for the CY-CIAE230 cyclotron is operated in driven push–pull mode. The two-way amplifier-coupler-cavity systems are operated with approximately the same amount of RF power but 180° out of phase compared with each other. The design, as well as the technical advantage and limitations of this operating mode, of the CYCIAE230 cyclotron RF system is analyzed.

Design of RF system for CYCIAE-230 superconducting cyclotron

Science.gov (United States)

Yin, Zhiguo; Ji, Bin; Fu, Xiaoliang; Cao, Xuelong; Zhao, Zhenlu; Zhang, Tinajue

2017-05-01

The CYCIAE230 is a low-current, compact superconducting cyclotron designed for proton therapy. The Radio Frequency system consists of four RF cavities and applies second harmonic to accelerate beams. The driving power for the cavity system is estimated to be approximately 150 kW. The LLRF controller is a self-made device developed and tested at low power using a small-scale cavity model. In this paper, the resonator systems of an S.C. cyclotron in history are reviewed. Contrary to those RF systems, the cavities of the CYCIAE230 cyclotron connect two opposite dees. Two high-power RF windows are included in the system. Each window carries approximately 75 kW RF power from the driver to the cavities. Thus, the RF system for the CY-CIAE230 cyclotron is operated in driven push-pull mode. The two-way amplifier-coupler-cavity systems are operated with approximately the same amount of RF power but 180° out of phase compared with each other. The design, as well as the technical advantage and limitations of this operating mode, of the CYCIAE230 cyclotron RF system is analyzed.

Compact superconducting 250 MeV proton cyclotron for the PSI PROSCAN proton therapy project

International Nuclear Information System (INIS)

Schillo, M.; Geisler, A.; Hobl, A.; Klein, H.U.; Krischel, D.; Meyer-Reumers, M.; Piel, C.; Blosser, H.; Kim, J.-W.; Marti, F.; Vincent, J.; Brandenburg, S.; Beijers, J.P.M.

2001-01-01

A cyclotron for proton therapy has to fulfill many requirements set by the specific operational and safety needs of a medical facility and the medical environment. These are for instance high extraction efficiency, high availability and reliability, simple and robust operation. ACCEL Instruments GmbH has refined the design concept of a medical cyclotron for the PSI PROSCAN project with the objective to use this cyclotron as the standard accelerator in complete proton therapy facilities, which ACCEL intends to market. Starting from the design, we have carried out further detail clarifications, optimizations and adaptations to the needs of PSI. The work was performed in a collaboration between ACCEL, NSCL and KVI in view of the requirements from the PSI PROSCAN project. An overview on the design will be given touching on subjects such as the 3D structural analysis of the coil, detailed magnetic modeling for optimization of the inner region and the spiral, optimization of the RF power, optimization of the cryogenic design based on available cryocoolers instead of a liquefaction plant and Monte Carlo simulations to estimate the heat balance produced by neutrons at 4K components

Proceedings of eighth joint workshop on electron cyclotron emission and electron cyclotron resonance heating. Vol. 1

International Nuclear Information System (INIS)

1993-03-01

The theory of electron cyclotron resonance phenomena is highly developed. The main theoretical tools are well established, generally accepted and able to give a satisfactory description of the main results obtained in electron cyclotron emission, absorption and current drive experiments. In this workshop some advanced theoretical and numerical tools have been presented (e.g., 3-D Fokker-Planck codes, treatment of the r.f. beam as a whole, description of non-linear and finite-beam effects) together with the proposal for new scenarios for ECE and ECA measurements (e.g., for diagnosing suprathermal populations and their radial transport). (orig.)

Proceedings of eighth joint workshop on electron cyclotron emission and electron cyclotron resonance heating. Vol. 2

International Nuclear Information System (INIS)

1993-03-01

The theory of electron cyclotron resonance phenomena is highly developed. The main theoretical tools are well established, generally accepted and able to give a satisfactory description of the main results obtained in electron cyclotron emission, absorption and current drive experiments. In this workshop some advanced theoretical and numerical tools have been presented (e.g., 3-D Fokker-Planck codes, treatment of the r.f. beam as a whole, description of non-linear and finite-beam effects) together with the proposal for new scenarios for ECE and ECA measurements (e.g., for diagnosing suprathermal populations and their radial transport). (orig.)

Automated cyclotron tuning using beam phase measurements

International Nuclear Information System (INIS)

Timmer, J.H.; Roecken, H.; Stephani, T.; Baumgarten, C.; Geisler, A.

2006-01-01

The ACCEL K250 superconducting cyclotron is specifically designed for the use in proton therapy systems. The compact medical 250 MeV proton accelerator fulfils all present and future beam requirements for fast scanning treatment systems and is delivered as a turn key system; no operator is routinely required. During operation of the cyclotron heat dissipation of the RF system induces a small drift in iron temperature. This temperature drift slightly detunes the magnetic field and small corrections must be made. A non-destructive beam phase detector has been developed to measure and quantify the effect of a magnetic field drift. Signal calculations were made and the design of the capacitive pickup probe was optimised to cover the desired beam current range. Measurements showed a very good agreement with the calculated signals and beam phase can be measured with currents down to 3 nA. The measured phase values are used as input for a feedback loop controlling the current in the superconducting coil. The magnetic field of the cyclotron is tuned automatically and online to maintain a fixed beam phase. Extraction efficiency is thereby optimised continuously and activation of the cyclotron is minimised. The energy and position stability of the extracted beam are well within specification

A visual assistance environment for cyclotron operation

International Nuclear Information System (INIS)

Okamura, Tetsuya; Murakami, Tohru; Agematsu, Takashi; Okumura, Susumu; Arakawa, Kazuo.

1993-01-01

A computer-based operation system for a cyclotron which assists inexperienced operators has been developed. Cyclotron start-up operations require dozens of adjustable parameters to be finely tuned to maximize extracted beam current. The human interfaces of the system provide a visual environment designed to enhance beam parameter adjustments. First, the mental model of operators is analyzed. It is supposed to be composed of five partial mental models: beam behavior model, feasible setting regions model, parameter sensitivity model, parameter mutual relation model, and status map model. Next, based on these models, three visual interfaces are developed, i.e., (1) Beam trajectory is rapidly calculated and graphically displayed whenever the operators change the cyclotron parameters. (2) Feasible setting regions (FSR) of the parameters that satisfy the cyclotron's beam acceptance criteria are indicated. (3) Search traces, being a historical visual map of beam current values, are superimposed on the FSRs. Finally, to evaluate system effectiveness, the search time required to reach maximum beam current conditions was measured. In addition, system operability was evaluated using written questionnaires. Results of the experiment showed that the search time to reach specific beam conditions was reduced by approximately 65% using these interfaces. The written questionnaires survey showed the operators highly evaluate system operability. (author)

A numerical model of the mirror electron cyclotron resonance MECR source

International Nuclear Information System (INIS)

Hellblom, G.

1986-03-01

Results from numerical modeling of a new type of ion source are presented. The plasma in this source is produced by electron cyclotron resonance in a strong conversion magnetic field. Experiments have shown that a well-defined plasma column, extended along the magnetic field (z-axis) can be produced. The electron temperature and the densities of the various plasma particles have been found to have a strong z-position dependence. With the numerical model, a simulation of the evolution of the composition of the plasma as a function of z is made. A qualitative agreement with experimental data can be obtained for certain parameter regimes. (author)

Studies on a Q/A selector for the SECRAL electron cyclotron resonance ion source.

Science.gov (United States)

Yang, Y; Sun, L T; Feng, Y C; Fang, X; Lu, W; Zhang, W H; Cao, Y; Zhang, X Z; Zhao, H W

2014-08-01

Electron cyclotron resonance ion sources are widely used in heavy ion accelerators in the world because they are capable of producing high current beams of highly charged ions. However, the design of the Q/A selector system for these devices is challenging, because it must have a sufficient ion resolution while controlling the beam emittance growth. Moreover, this system has to be matched for a wide range of ion beam species with different intensities. In this paper, research on the Q/A selector system at the SECRAL (Superconducting Electron Cyclotron Resonance ion source with Advanced design in Lanzhou) platform both in experiment and simulation is presented. Based on this study, a new Q/A selector system has been designed for SECRAL II. The features of the new design including beam simulations are also presented.

Calculation of proton beam initial orbit at cyclotron central region

International Nuclear Information System (INIS)

Pramudita Anggraita

2012-01-01

A calculation of proton beam initial orbits at cyclotron central region was carried out using Scilab 5.2.0. The calculation was done in 2 dimensions in a homogeneous magnetic field of 1.66 tesla at frequency of fourth harmonics. The positions of ion source, dees, and dummy dees follow those of GE Minitrace cyclotron, peak dee voltage 30 kV. The calculation yields result comparable to those simulated at KIRAMS-13 cyclotron. (author)

Extreme radionuclide accumulation on alpine glaciers in cryoconites

International Nuclear Information System (INIS)

Lettner, H.; Wilflinger, T.; Hubmer, A.K.; Bossew, P.

2008-01-01

Full text: Under environmental conditions when radionuclide fallout will not be diluted by media like soil or water, radionuclides deposited may accumulate to unusual high activities. On glacier surfaces conditions as such exist for aerosols and airborne dust deposited with anthropogenic and natural radionuclides attached on their surfaces. In the course of agglomeration processes initiated by melting and redistribution, these particles may concentrate in small depressions, ice pockets, ablation edges etc. and form substances called cryoconites ('ice dust'). As there is no other matrix than the original aerosol particles, cryoconites are a sink for radionuclides and airborne pollutants and their activity levels are among the highest produced by natural processes observed in environmental media. 137 Cs activities found on glaciers in the Austrian alps are between 255 and 136.000 Bq/kg and predominantly derived from Chernobyl, but also from global fallout. Further anthropogenic radionuclides detected are 134 Cs, 90 Sr, 238,239+240 Pu, 241 Am, 125 Sb, 154 Eu, 60 Co and 207 Bi. In combination with the naturally occurring radionuclides 7 Be and 210 Pb and isotopic ratios such as 134 Cs/ 137 Cs, identification and discrimination of the sources, the nuclear weapon tests and the Chernobyl fallout, can be carried out. (author)

Optimisation of magnetic field and R.F. in a azimuthally varying field variable energy cyclotrons

International Nuclear Information System (INIS)

Ismail, M.; Divatia, A.S.

1975-01-01

A computer program is developed for determining magnetic field and reference frequency. Setting necessary to produce a specific ion beam with a given energy in variable energy cyclotrons. The program carries out field trimming calculations using an iterated least square process. For each of the prescribed set of energy values, the E.O. code computes the relevant properties of the equilibrium orbit and the linear oscillation about this orbit to assess the merits and defects of a given medium field. The program consists of parts for: (1) Fourier analysis of the magnetic field (2) calculation of cyclotron trim-coil currents for field optimization (3) generating data for equilibrium orbit (4) determination of the phase energy characteristic of the ion beam and (5) iteration process. (M.G.B.)

Naturally occurring radionuclides in food and drinking water from a thorium-rich area

International Nuclear Information System (INIS)

Costa Lauria, Dejanira da; Rochedo, Elaine R.R.; Godoy, Maria Luisa D.P.; Santos, Eliane E.; Hacon, Sandra S.

2012-01-01

This paper focuses on a survey of uranium and thorium decay chain radionuclides in food and drinking water from the thorium-rich (monazite-bearing) region of Buena, which is located in the state of Rio de Janeiro, Brazil. The radionuclide concentration values in the food and drinking water from Buena reached values higher than 100-fold the international reference values. The daily intake of radionuclides by the local population is similar to that of another high background radiation area in Brazil, but the intake is higher than that of residents from a normal background radiation area. Approximately 58 % of the food consumed by Buena inhabitants is produced locally. Based on that figure, locally produced food and the dilution of total radionuclides in the diet of residents caused by food importation are both highly relevant to a population's intake of radionuclides. The concentration values for 210 Pb and the radium isotopes in drinking water from Buena are among the highest values to be reported in the literature. 228 Ra is the most important radionuclide ingested with both food and water among the inhabitants of Buena. (orig.)

Electromagnetic ion cyclotron waves observed near the oxygen cyclotron frequency by ISEE 1 and 2

International Nuclear Information System (INIS)

Fraser, B.J.; Samson, J.C.; Hu, Y.D.; McPherron, R.L.; Russell, C.T.

1992-01-01

Pc 2 electromagnetic ion cyclotron waves at 0.1 waves at 0.1 Hz, near the oxygen cyclotron frequency, have been observed by ISEE 1 and 2 between L = 7.6 and 5.8 on an inbound near-equatorial pass in the dusk sector. The waves occurred in a thick plasmapause of width ∼ 1.5 R E and penetrated ∼1 R E into the plasmasphere. Wave onset was accompanied by significant increases in the thermal (0-100 eV) He + and the warm (0.1-16 keV/e) O + and He + heavy ion populations. The most intense waves (8 nT) were observed in the outer plasmasphere where convection drift velocities (E x B)/B 2 were largest and the Alfven velocity was a minimum. Wave polarization is predominantly left-handed with propagation almost parallel to the ambient magnetic field, and the spectral slot and polarization reversal predicted by cold plasma propagation theory are identified in the wave data. Poynting fluxes calculated during the first 15 min of the event show wave energy propagation directions both parallel and antiparallel to the field. Computations of the experimental wave spectra during the passage through the plasmapause show that the spectral slots relate to local plasma parameters, possibly suggesting an ion cyclotron wave growth source near the spacecraft. A regular wave packet structure seen over the first 30 min of the event may be attributed to the modulation of this energy source by the Pc 5 waves seen at the same time. Overall, the results are considered an example of an electromagnetic ion cyclotron wave-particle interaction occurring during the outer plasmasphere refilling process at the time of the substorm recovery phase

Heating tokamaks via the ion-cyclotron and ion-ion hybrid resonances

International Nuclear Information System (INIS)

Perkins, F.W.

1977-04-01

For the ion-ion hybrid resonance it is shown that: (1) the energy absorption occurs via a sequence of mode conversions; (2) a poloidal field component normal to the ion-ion hybrid mode conversion surface strongly influences the mode conversion process so that roughly equal electron and ion heating occurs in the present proton-deuterium experiments, while solely electron heating is predicted to prevail in deuterium-tritium reactors; (3) the ion-ion hybrid resonance suppresses toroidal eigenmodes; and (4) wave absorption in minority fundamental ion-cyclotron heating experiments will be dominated by ion-ion hybrid mode conversion absorption for minority concentrations exceeding roughly 1 percent. For the ion-cyclotron resonance, it is shown that: (1) ion-cyclotron mode conversion leads to surface electron heating; and (2) ion-cyclotron mode conversion absorption dominates fundamental ion-cyclotron absorption thereby preventing efficient ion heating

Radionuclide trap

International Nuclear Information System (INIS)

McGuire, J.C.

1978-01-01

The deposition of radionuclides manganese-54, cobalt-58 and cobalt-60 from liquid sodium coolant is controlled by providing surfaces of nickel or high nickel alloys to extract the radionuclides from the liquid sodium, and by providing surfaces of tungsten, molybdenum or tantalum to prevent or retard radionuclide deposition

Ion Cyclotron Resonance Facility (ICR)

Data.gov (United States)

Federal Laboratory Consortium — his facility is charged with developing and exploiting the unique capabilities of Fourier Transform Ion Cyclotron Resonance (FT-ICR) mass spectrometry, and leads the...

Present status of device controls and hardware interfaces for the RCNP ring cyclotron

International Nuclear Information System (INIS)

Yamazaki, T.; Tamura, K.; Hosono, K.

1994-01-01

Since the first proton beam from the injector AVF cyclotron was injected to the ring cyclotron in 1991, the computer control system has been used for the beam acceleration of the ring cyclotron. Some device control modules have been updated, and computer configuration has been changed in 1992. Total control system performs basic facilities almost satisfactory under actual cyclotron operation. (author)

Cyclotron based nuclear science: Progress report, April 1, 1987-March 31, 1988

International Nuclear Information System (INIS)

1988-08-01

This report discusses experiment run on the K500 cyclotron and 88 in cyclotron at Texas AandM University. The main topics of these experiments are: Heavy ion reactions; Nuclear structure and fundamental interactions; Atomic and material science; Nuclear theory; and Superconducting cyclotron and instrumentation

A basis for modelling of radionuclide flow in the Forsmark biotest basin

International Nuclear Information System (INIS)

Notter, M.; Snoeijs, P.; Argaerde, L.; Elert, M.

1987-01-01

Certain radionuclides are discharged together with the cooling water of Forsmark power station. Of these, Mn-54, Co-60, Zn-65 and Ag-110 m are easily detectable in the environment. This report gives a conceptual five-compartment model for the flows of radionuclides within the basin ecosystem. The available data from biological and radio-ecological investigations in the biotest basin were used to quantify the amounts of radionuclides in each of the reservoirs. The subsystem water-sediment-primary producers was pointed out to be the most interesting part of the ecosystem for studying radionuclides with mathematical modelling in the future. (orig./DG)

Biological distribution of [18F-FDG] using reactor produced [18F

International Nuclear Information System (INIS)

Sierralta, P.; Massardo, T; Gil, M.C; Gonzalez, P; Chandia, M.; Godoy, N.; Troncoso, F

2002-01-01

The animal model that relates biodistribution of a substance is fundamental prior to using it in human beings. For the evaluation of myocardial viability after a recent MI, the use of reactor produced [ 18 F]-FDG (a radiotracer usually obtained in Cyclotron) is proposed, production of which has never been attempted in our country. Specific Activities founded in the different tissues after injection of this radiotracer in an animal model were compared with those obtained by other authors with cyclotron [ 18 F]-FDG. No statistically significant differences in the critical organs were found. Hence, reactor produced [ 18 F]-FDG is a useful radiopharmaceutical in cardiac cellular metabolism assessment (author)

Progress report on the Milan superconducting cyclotron

International Nuclear Information System (INIS)

Acerbi, E.; Alessandria, F.; Baccaglioni, G.; Bellomo, G.; Birattari, C.; Bosotti, A.; Broggi, F.; Cortesi, G.; DeMartinis, C.; Fabrici, E.; Ferrari, A.; Giove, D.; Giussani, A.; Giussani, W.; Michelato, P.; Pagani, C.; Rivoltella, G.; Rossi, L.; Serafini, L.; Sussetto, A.; Torri, V.; Varisco, G.; Cuttone, G.; Raia, G.; Kai, L.

1988-01-01

This paper reports on the construction of the K800 superconducting cyclotron at the University of Milan underway since February 1981. The delay in the construction of the new building and a defect of the weldings of the helium vessel have caused a shift in the project schedule of about two years. Currently, the cyclotron magnet and the cryogenic plant have been completed and installed. First operation of the magnet and magnetic field mapping are to begin shortly

TORCAPP: time-dependent cyclotron orbit calculation and plotting package

International Nuclear Information System (INIS)

Maddox, L.B.; McNeilly, G.S.

1979-11-01

TORCAPP calculates the motion of charged particles in electromagnetic fields with time as the independent variable, and produces a variety of printed and plotted output of results. Finite-size beam behavior is studied conveniently by following groups of particles which define an appropriate phase space area. Since time is the independent variable, general motion in the near-median-plane region may be followed. This includes, for example, loops not enclosing the origin and strongly radial motions. Thus, TORCAPP is particularly useful for injection studies for isochronous cyclotrons, or other devices with near-median-plane charged particle motion

Scientific instruments, scientific progress and the cyclotron

International Nuclear Information System (INIS)

Baird, David; Faust, Thomas

1990-01-01

Philosophers speak of science in terms of theory and experiment, yet when they speak of the progress of scientific knowledge they speak in terms of theory alone. In this article it is claimed that scientific knowledge consists of, among other things, scientific instruments and instrumental techniques and not simply of some kind of justified beliefs. It is argued that one aspect of scientific progress can be characterized relatively straightforwardly - the accumulation of new scientific instruments. The development of the cyclotron is taken to illustrate this point. Eight different activities which promoted the successful completion of the cyclotron are recognised. The importance is in the machine rather than the experiments which could be run on it and the focus is on how the cyclotron came into being, not how it was subsequently used. The completed instrument is seen as a useful unit of scientific progress in its own right. (UK)

Composition and B-H curve analysis of low carbon steel from Krakatau Steel company using VSM And EDX for magnet design of 13 MeV cyclotron

International Nuclear Information System (INIS)

Taufik; Emy Mulyani; Kusminarto; Slamet Santosa

2012-01-01

Cyclotron is one type of particle accelerator that accelerate particle in circular trajectory, in order to obtain high kinetic energy. One of the main components is the cyclotron magnet system that serves to form a cyclic particle trajectories and made of forged low carbon steel. In the magnet design, the selection of magnetic materials is very important in determining whether cyclotron magnet can operate properly or not and even can be optimal. That is why we need to test samples of magnetic materials from local production in this case two samples of material produced by PT Krakatau Steel (KS). Tests performed include testing of BH curve using VSM (Vibrating Sample Magnetometer) and material composition using EDX (Energy-dispersive X-ray spectroscopy). Obtained BH curve is used as material data in three-dimensional simulation using the Opera 3D with referee to magnetic model of Kirams 13. From this study it can be concluded that the position of the test object to the direction of the magnetic field induction gives different BH curve and the samples obtained from KS has a carbon content which is still high. The lower the carbon content in the iron will produce a better magnetic properties. Material samples analyzed will produce a field that is not optimal when it is used in a 13 MeV cyclotron magnet. (author)

Cyclotron operating mode determination based on intelligent methods

International Nuclear Information System (INIS)

Ouda, M.M.E.M.

2011-01-01

Particle accelerators are generators that produce beams of charged particles with energies depending on the accelerator type. The MGC-20 cyclotron is a cyclic particle accelerator used for accelerating protons, deuterons, alpha particles, and helium-3 to different energies. Main applications are isotopes production, nuclear reactions studies, and mass spectroscopy studies and other industrial applications. The cyclotron is a complicated machine depends on using a strong magnetic field and high frequency-high voltage electric field together to accelerate and bend charged particles inside the accelerating chamber. It consists of the following main parts, the radio frequency system, the main magnet with the auxiliary concentric and harmonic coils, the electrostatic deflector, and the ion source, the beam transport system, and high precision and high stability DC power supplies.To accelerate a particle to certain energy, one has to adjust the cyclotron operating parameters to be suitable to accelerate this particle to that energy. If the cyclotron operating parameters together are adjusted to accelerate a charged particle to certain energy, then these parameters together are named the operating mode to accelerate this particle to that energy. For example the operating mode to accelerate protons to 18 MeV is named the (18 MeV protons operating mode). The operating mode includes many parameters that must be adjusted together to be successful to accelerate, extract, focus, steer a particle from the ion source to the experiment. Due to the big number of parameters in the operating modes, 19 parameters have been selected in this thesis to be used in an intelligent system based on feed forward back propagation neural network to determine the parameters for new operating modes. The new intelligent system depends on the available information about the currently used operating modes.The classic way to determine a new operating mode was depending on trial and error method to

Cyclotrons at the Institute of Physical and Chemical Research

International Nuclear Information System (INIS)

Imamura, Masashi.

1989-01-01

In this article the destruction by American forces, during World War II, of the Japanese cyclotrons and the subsequent construction of new cyclotrons at the Institute of Physical and Chemical Research, Japan is described. Their use for biological and medical radiation chemistry studies is summarized. (UK)

Radionuclide cisternography

International Nuclear Information System (INIS)

Song, H.H.

1980-01-01

The purpose of this thesis is to show that radionuclide cisternography makes an essential contribution to the investigation of cerebrospinal fluid (CSF) dynamics, especially for the investigation of hydrocephalus. The technical details of radionuclide cisternography are discussed, followed by a description of the normal and abnormal radionuclide cisternograms. The dynamics of CFS by means of radionuclide cisternography were examined in 188 patients in whom some kind of hydrocephalus was suspected. This study included findings of anomalies associated with hydrocephalus in a number of cases, such as nasal liquorrhea, hygromas, leptomeningeal or porencephalic cysts. The investigation substantiates the value of radionuclide cisternography in the diagnosis of disturbances of CSF flow. The retrograde flow of radiopharmaceutical into the ventricular system (ventricular reflux) is an abnormal phenomenon indicating the presence of communicating hydrocephalus. (Auth.)

High power targets for cyclotron production of 99mTc‡

OpenAIRE

Zeisler, S. K.; Hanemaayer, V.; Buckley, K. R.; Hook, B. K.; MeDiarmid, S.; Klug, J.; Corsaut, J.; Kovacs, M.; Cockburn, N.; Exonomou, C.; Harper, R.; Valliant, J. F.; Ruth, T. J.; Schaffer, P.

2015-01-01

Introduction Technetium-99m, supplied in the form of 99Mo/99mTc generators, is the most widely used radioisotope for nuclear medical imaging. The parent isotope 99Mo is currently produced in nuclear reactors. Recent disruptions in the 99Mo supply chain [1] prompted the development of methods for the direct accelerator-based production of 99mTc. Our approach involves the 100Mo(p,2n)99mTc reaction on isotopically enriched molybdenum using small medical cyclotrons (Ep ≤ 20 MeV), which is ...

Ion cyclotron resonance heating

International Nuclear Information System (INIS)

Tajima, T.

1982-01-01

Ion cyclotron resonance heating of plasmas in tokamak and EBT configurations has been studied using 1-2/2 and 2-1/2 dimensional fully self-consistent electromagnetic particle codes. We have tested two major antenna configurations; we have also compared heating efficiencies for one and two ion species plasmas. We model a tokamak plasma with a uniform poloidal field and 1/R toroidal field on a particular q surface. Ion cyclotron waves are excited on the low field side by antennas parallel either to the poloidal direction or to the toroidal direction with different phase velocities. In 2D, minority ion heating (vsub(perpendicular)) and electron heating (vsub(parallel),vsub(perpendicular)) are observed. The exponential electron heating seems due to the decay instability. The minority heating is consistent with mode conversion of fast Alfven waves and heating by electrostatic ion cyclotron modes. Minority heating is stronger with a poloidal antenna. The strong electron heating is accompanied by toroidal current generation. In 1D, no thermal instability was observed and only strong minority heating resulted. For an EBT plasma we model it by a multiple mirror. We have tested heating efficiency with various minority concentrations, temperatures, mirror ratios, and phase velocities. In this geometry we have beach or inverse beach heating associated with the mode conversion layer perpendicular to the toroidal field. No appreciable electron heating is observed. Heating of ions is linear in time. For both tokamak and EBT slight majority heating above the collisional rate is observed due to the second harmonic heating. (author)

Intelligent CAE system of CYCLONE type cyclotron main magnet and its applications

International Nuclear Information System (INIS)

Zhang Tianjue; Chen Yong; Fan Mingwu

1993-01-01

The main magnet that features the cyclotron is the most important part in a cyclotron construction. Though there are many codes devoted to solving magnetic field computation problems, the results depend on the user's skill and experience very much. To help a cyclotron magnet designer get acceptable results, an intelligent CAE system for CYCLONE type cyclotron magnet design and machining has been developed. Reasonable good results could be got even the designer with the help from an expert knowledge library installed in the program

Passive cyclotron current drive for fusion plasmas

International Nuclear Information System (INIS)

Kernbichler, W.

1995-01-01

The creation of toroidal current using cyclotron radiation in a passive way is, together with the well known bootstrap current, an interesting method for stationary current drive in high-temperature fusion reactors. Here, instead of externally applied RF-waves, fish-scale like structures at the first wall help to create enough asymmetry in the self generated cyclotron radiation intensity to drive a current within the plasma. The problem of computing passive cyclotron current drive consists of actually two linked problems, which are the computation of the electron equilibrium under the presence of self-generated radiation, and the computation of the photon equilibrium in a bounded system with a distorted electron distribution. This system of integro-differential equations cannot be solved directly in an efficient way. Therefore a linearization procedure was developed to decouple both sets of equations, finally linked through a generalized local current drive efficiency. The problem of the exact accounting for the wall profile effects was reduced to the solution of a Fredholm-type integral equation of the 2 nd -kind. Based on all this an extensive computer code was developed to compute the passively driven current as well as radiation losses, radiation transport and overall efficiencies. The results therefrom give an interesting and very detailed insight into the problems related to passive cyclotron current drive

Study of axial injection of polarized protons into the grenoble cyclotron; Contribution a l'etude de l'injection axiale pour protons polarises sur le cyclotron de Grenoble

Energy Technology Data Exchange (ETDEWEB)

Pabot, J [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1969-07-01

By injecting ions axially into a cyclotron, it is possible to accelerate particles (polarized particles, heavy ions, etc...) obtainable only with difficulty when an internal ion source is used. In this work, after justifying the choice of an axial injection device equipped with a 'pseudo-cylindrical' deflector for the Grenoble cyclotron, we study theoretically the principle of such a detector, the choice of its parameters, and the effect of this choice on the conditions of acceleration of the beam by the cyclotron. From the experimental point of view, this report describes two operations which made it possible to check that the chosen injection device operated satisfactorily, qualitatively initially (electron model), then quantitatively (proton model). In conclusion, we believe that the Grenoble cyclotron thus equipped will be able to provide a relatively dense beam of polarized protons. (author) [French] L'injection axiale d'ions dans un cyclotron permet d'accelerer des particules (particules polarisees, ions lourds... ) difficiles a obtenir avec une source interne d'ions. Dans ce travail, apres avoir justifie le choix d'un dispositif d'injection axiale equipe d'un deflecteur 'pseudo-cylindrique' pour le cyclotron de Grenoble, nous avons etudie, du point de vue theorique, le principe d'un tel deflecteur, le choix de ses parametres, et l'incidence de ce choix sur les conditions d'acceleration du faisceau par le cyclotron. Du point de vue experimental, ce rapport decrit deux manipulations qui ont permis de verifier le bon fonctionnement du dispositif d'injection retenu, qualitativement d'abord (modele a electrons), quantitativement ensuite (maquette a protons). En conclusion, nous estimons que le cyclotron de Grenoble ainsi equipe, peut fournir un faisceau relativement intense de protons polarises. (auteur)

Estimation of induced activity in super conducting cyclotron at VECC: Monte Carlo calculations

International Nuclear Information System (INIS)

Chatterjee, S.; Bandyopadhyay, T.

2011-01-01

Super Conducting Cyclotron (K500) at Variable Energy Cyclotron Centre, Kolkata (VECC) is at an advanced stage of commissioning and has successfully delivered many internal beams (light to heavy particles) up to the extraction radius. One of the external beam lines has already been completed and commissioned. The SCC along with the other subsystems is getting ready to deliver beam for experiments. Beam loss of during beam tuning and also during a steady beam delivery to the different experimental facilities due to many operational factors and requirements. Extraction of beam from the machine to the beam line is also a major player for the loss of beam. The interaction of the lost beam of accelerated charge particles with the machine parts will undergo different nuclear reaction and induced activity will be produced at the different parts of the machine. Moreover secondary neutrons produced having energy maximum limiting to the beam energy will also produce radioactivity in the different parts of the machine as well it will also induce radioactivity on the radiation shield constructed around the accelerator. Radio-activation of different parts of an accelerator, radiation shield walls around the machine and materials available in the room poses a radiation hazard inside the machine vault and experimental caves especially during maintenance of the machine. During the shutdown and maintenance period of the machine occupational workers will be exposed to these induced activity produced during operation of the machine. An effort was made to estimate these residual activity and dose for 80 MeV proton bombarded on Stainless Steel thereon activity produced on different materials like Cu, Al, Concrete and SS of different thickness. Cu, Al, SS are among many other materials which are widely used for fabrication of any accelerator. A simulation of the scenario was created using a Monte Carlo approach using FLUKA 2006.3b-general purpose multi particle transport code. Estimation

Operation of the Karlsruhe Isochronous Cyclotron in 1976

International Nuclear Information System (INIS)

Schulz, F.; Schweickert, H.

1977-08-01