WorldWideScience

Sample records for current understanding suggests

  1. Gifted Male Readers: Current Understandings and Suggestions for Future Research

    Science.gov (United States)

    Pagnani, Alexander R.

    2013-01-01

    Research literature concerning gifted male readers relies primarily on more extensive bodies of work regarding gifted males and male readers. Studied as a whole, the two halves portray a worrisome state of affairs for gifted male readers, who lag behind their female counterparts in the same patterns found across the ability spectrum. This literacy…

  2. Current and Suggested focus on Sustainability in Pyrometallurgy

    Science.gov (United States)

    See, J. B.; Robertson, D. G. C.; Mackey, P. J.

    The production of iron and steel and non-ferrous metals by pyrometallurgical processes will remain a critical element in meeting the demand for materials in both developed and developing nations. Given the important need to reduce and minimise greenhouse gas emissions the technological focus of future pyrometallurgical R&D by universities and industry alike must concentrate on sustainability issues such as improved energy efficiency, recycling and waste minimization. Continued efforts are also needed on process optimization and new process development with a view to reducing capital and operating costs of the new large "mega" plants. Using the academic and industrial backgrounds of the authors, the present paper reviews the current status of R&D in pyrometallurgy in university departments with a particular emphasis on sustainability issues. The role of industry and government laboratories is also reviewed although primarily for developed countries. The paper also includes comments and suggestions on the future requirements for education and R&D in pyrometallurgy in developed countries to maximise sustainability. It is also suggested that future R&D in pyrometallurgy will be even more concentrated in developing countries — most notably China.

  3. Understanding Nanocalcification: A Role Suggested for Crystal Ghosts

    Directory of Open Access Journals (Sweden)

    Ermanno Bonucci

    2014-07-01

    Full Text Available The present survey deals with the initial stage of the calcification process in bone and other hard tissues, with special reference to the organic-inorganic relationship and the transformation that the early inorganic particles undergo as the process moves towards completion. Electron microscope studies clearly exclude the possibility that these particles might be crystalline structures, as often believed, by showing that they are, instead, organic-inorganic hybrids, each comprising a filamentous organic component (the crystal ghost made up of acidic proteins. The hypothesis is suggested that the crystal ghosts bind and stabilize amorphous calcium phosphate and that their subsequent degradation allows the calcium phosphate, once released, to acquire a hydroxyapatite, crystal-like organization. A conclusive view of the mechanism of biological calcification cannot yet be proposed; even so, however, the role of crystal ghosts as a template of the structures usually called “crystallites” is a concept that has gathered increasing support and can no longer be disregarded.

  4. Current Situation in Vocational Schools: Issues and Some Suggested Solutions

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    Reha Metin ALKAN

    2014-12-01

    Full Text Available Vocational Schools which have undertaken various missions throughout history were established in order to train intermediate staff s with suff icient knowledge and skills in their fields, in accordance with the requirements of trade, industry and services sectors and they are the most important components of ‘vocational and technical education system' today. Analyzing the education given in the vocational schools in accordance with the national and international requirements, developing technologies and the needs of business world and making the necessary arrangements in line with these will contribute to the employability and preferability of graduates of these schools in an eff icient way. Many industrialists/businessmen in our country stated that they experienced serious problems in the supply of qualified staff with suff icient knowledge and skills needed in sectors. Although much progress has been achieved in this subject, it is a fact that there are still a lot of work to be done. In this study, current situation and main troubles in vocational schools are discussed in the light of the experiences gained at Hitit University Vocational School which was established about 40 years ago in Çorum and which is one of the first high schools in Turkey and some solutions are suggested in accordance with the problems mentioned.

  5. The Current State of China's Freshwater Resources and Related Suggestions

    Institute of Scientific and Technical Information of China (English)

    Wu Ruijin

    2001-01-01

    China has many lakes, marshlands and rivers. Due to their uneven geographical distribution and varied degrees of salinity, their exploitable freshwater resources are limited. In the wake of the highspeed growth of national economy in recent years, human infringement upon their natural settings has been increasingly intense, leading to the degeneration of China's lacustrine ecosystems and the degradation of their surrounding environments. Lakes are shrinking and becoming more saline. In arid and semi-arid inland areas, some of them have even disappeared. In addition, lake water pollution and eutrophication in densely populated areas are getting worse, resulting in serious water shortages in some places. Silt deposition in lake basins, water surface shrinkage caused by hectic and irrational reclamation for farmland, the prevalence of flooding and water-logging calamities and ecosystem depletion caused by predatory exploitation of fishery resources, all of these have become restrictive factors in regional sustainable development. The author of this article suggests measures for the protection and sustainable exploitation of limnetic settings in China.

  6. Current understanding of the aeronomy of Mars

    Science.gov (United States)

    Nagy, Andrew F.; Grebowsky, Joseph M.

    2015-12-01

    This paper provides a short overview of our current understanding of the upper atmosphere/ionosphere of Mars including the escaping neutral atmosphere to space that plays a key role in the current state of the Mars upper atmosphere. The proper definition of the word "aeronomy" relates to the upper atmosphere where ionization is important. Currently there is a paucity of measurements of the internal physical structure of the Martian upper atmosphere/ionosphere. Much that we know has been deduced from theoretical models that predict many more things than thus far measured. The newest Mars orbital missions, the US MAVEN and Indian MOM missions, just beginning their science analyses, will provide the measurements needed to fully characterize the aeronomy of Mars.

  7. Resistance to AHAS inhibitor herbicides: current understanding.

    Science.gov (United States)

    Yu, Qin; Powles, Stephen B

    2014-09-01

    Acetohydroxyacid synthase (AHAS) inhibitor herbicides currently comprise the largest site-of-action group (with 54 active ingredients across five chemical groups) and have been widely used in world agriculture since they were first introduced in 1982. Resistance evolution in weeds to AHAS inhibitors has been rapid and identified in populations of many weed species. Often, evolved resistance is associated with point mutations in the target AHAS gene; however non-target-site enhanced herbicide metabolism occurs as well. Many AHAS gene resistance mutations can occur and be rapidly enriched owing to a high initial resistance gene frequency, simple and dominant genetic inheritance and lack of major fitness cost of the resistance alleles. Major advances in the elucidation of the crystal structure of the AHAS (Arabidopsis thaliana) catalytic subunit in complex with various AHAS inhibitor herbicides have greatly improved current understanding of the detailed molecular interactions between AHAS, cofactors and herbicides. Compared with target-site resistance, non-target-site resistance to AHAS inhibitor herbicides is less studied and hence less understood. In a few well-studied cases, non-target-site resistance is due to enhanced rates of herbicide metabolism (metabolic resistance), mimicking that occurring in tolerant crop species and often involving cytochrome P450 monooxygenases. However, the specific herbicide-metabolising, resistance-endowing genes are yet to be identified in resistant weed species. The current state of mechanistic understanding of AHAS inhibitor herbicide resistance is reviewed, and outstanding research issues are outlined.

  8. Radiodermatitis: A Review of Our Current Understanding.

    Science.gov (United States)

    Singh, Manni; Alavi, Afsaneh; Wong, Rebecca; Akita, Sadanori

    2016-06-01

    Radiodermatitis (radiation dermatitis, radiation-induced skin reactions, or radiation injury) is a significant side effect of ionizing radiation delivered to the skin during cancer treatment as well as a result of nuclear attacks and disasters, such as that which occurred in Fukushima in 2011. More specifically, 95 % of cancer patients receiving radiation therapy will develop some form of radiodermatitis, including erythema, dry desquamation, and moist desquamation. These radiation skin reactions result in a myriad of complications, including delays in treatment, diminished aesthetic appeal, and reduced quality of life. Recent technological advancements and novel treatment regimens have only been successful in partly ameliorating these adverse side effects. This article examines the current knowledge surrounding the pathogenesis, clinical manifestations, differential diagnoses, prevention, and management of radiodermatitis. Future research should examine therapies that incorporate the current understanding of the pathophysiology of radiodermatitis while measuring effectiveness using objective and universal outcome measures.

  9. Current Understandings of Plant Nonhost Resistance.

    Science.gov (United States)

    Lee, Hyun-Ah; Lee, Hye-Young; Seo, Eunyoung; Lee, Joohyun; Kim, Saet-Byul; Oh, Soohyun; Choi, Eunbi; Choi, Eunhye; Lee, So Eui; Choi, Doil

    2017-01-01

    Nonhost resistance, a resistance of plant species against all nonadapted pathogens, is considered the most durable and efficient immune system of plants but yet remains elusive. The underlying mechanism of nonhost resistance has been investigated at multiple levels of plant defense for several decades. In this review, we have comprehensively surveyed the latest literature on nonhost resistance in terms of preinvasion, metabolic defense, pattern-triggered immunity, effector-triggered immunity, defense signaling, and possible application in crop protection. Overall, we summarize the current understanding of nonhost resistance mechanisms. Pre- and postinvasion is not much deviated from the knowledge on host resistance, except for a few specific cases. Further insights on the roles of the pattern recognition receptor gene family, multiple interactions between effectors from nonadapted pathogen and plant factors, and plant secondary metabolites in host range determination could expand our knowledge on nonhost resistance and provide efficient tools for future crop protection using combinational biotechnology approaches. [Formula: see text] Copyright © 2017 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .

  10. Hemiconvulsion-hemiplegia-epilepsy syndrome: current understandings.

    Science.gov (United States)

    Auvin, Stéphane; Bellavoine, Vanina; Merdariu, Dana; Delanoë, Catherine; Elmaleh-Bergés, Monique; Gressens, Pierre; Boespflug-Tanguy, Odile

    2012-09-01

    Hemiconvulsion-Hemiplegia (HH) syndrome is an uncommon consequence of prolonged focal febrile convulsive seizures in infancy and early childhood. It is characterized by the occurrence of prolonged clonic seizures with unilateral predominance occurring in a child and followed by the development of hemiplegia. Neuroradiological studies showed unilateral edematous swelling of the epileptic hemisphere at the time of initial status epilepticus (SE). This acute phase is followed by characteristic cerebral hemiatrophy with subsequent appearance of epilepsy, so called Hemiconvulsion-Hemiplegia-Epilepsy (HHE) syndrome. The etiologies and the underlying mechanisms remain to be understood. Using a review of the literature, we summarized the data of the last 20 years. It appears that idiopathic HH/HHE syndrome is the most common reported form. The basic science data suggest that immature brain is relatively resistant to SE-induced cell injury. Several factors might contribute to the pathogenesis of HH/HHE syndrome: 1. prolonged febrile seizure in which inflammation may worsen the level of cell injury; 2. inflammation and prolonged ictal activity that act on blood-brain-barrier permeability; 3. predisposing factors facilitating prolonged seizure such as genetic factors or focal epileptogenic lesion. However, these factors cannot explain the elective involvement of an entire hemisphere. We draw new hypothesis that may explain the involvement of one hemisphere such as maturation of brain structure such as corpus callosum or genetic factors (CACNA1A gene) that are specifically discussed. An early diagnosis and a better understanding of the underlying mechanisms of HHE are needed to improve the outcome of this condition.

  11. Current understanding in pathogenesis of atopic dermatitis

    Directory of Open Access Journals (Sweden)

    Tess McPherson

    2016-01-01

    Full Text Available There have been advances in our understanding of the complex pathogenesis of atopic eczema over the past few decades. This article examines the multiple factors which are implicated in this process.

  12. Progress in understanding halo current at JET

    Science.gov (United States)

    Riccardo, V.; Arnoux, G.; Beaumont, P.; Hacquin, S.; Hobirk, J.; Howell, D.; Huber, A.; Joffrin, E.; Koslowski, R.; Lam, N.; Leggate, H.; Rachlew, E.; Sergienko, G.; Stephen, A.; Todd, T.; Zerbini, M.; Delogu, R.; Grando, L.; Marcuzzi, D.; Peruzzo, S.; Pomaro, N.; Sonato, P.; JET EFDA Contributors

    2009-05-01

    The poloidal distribution of the halo current density on the top dump plate in JET can now be measured thanks to a new set of Rogowskii coils. These are the first measurements in JET able to offer an insight in the width of the halo current interaction with the wall. Therefore they offer both validation of the assumption made for JET disruption design criteria and one additional point in the extrapolation of the expected halo current width, and hence halo current density (and related local electro-mechanical loads on in-vessel components) for ITER. During upward events, the measured current density is consistent with the measured total poloidal halo current. The halo footprint extends over most of the upper dump plate, converting to a halo current flux tube width of ~100 mm. A set of four toridal field pick-up coils installed 90° apart now allows a more accurate measurement of the poloidal halo current, in particular its toroidal peaking factor, and direct comparison between halo and plasma asymmetries.

  13. Concussions in soccer: a current understanding.

    Science.gov (United States)

    Levy, Michael L; Kasasbeh, Aimen S; Baird, Lissa Catherine; Amene, Chiazo; Skeen, Jeff; Marshall, Larry

    2012-11-01

    Traumatic brain injury (TBI) is a significant public health problem in the United States, with approximately 1.5-2 million TBIs occurring each year. However, it is believed that these figures underestimate the true toll of TBI. Soccer is the most popular sport in the world and has a following of millions in the United States. Soccer is a sport not traditionally identified as high-risk for concussions, yet several studies have shown that concussion rates in soccer are comparable to, and often exceed those of, other contact sports. As many as 22% of all soccer injuries are concussions. Soccer is a sport not traditionally identified as high risk for concussions, yet several studies have shown that concussion rates in soccer are comparable to, and often exceed those of, other contact sports. As many as 22% of all soccer injuries are concussions. Head injury during soccer is usually the result of either "direct contact" or contact with the ball while "heading" the ball. Relationships between the number of headers sustained in a single season and the degree of cognitive impairment (attention and visual/verbal memory) have been demonstrated. It is also likely that multiple concussions may cause cumulative neuropsychologic impairment in soccer players. Although our understanding of risk factors for sports-related concussions is far from complete, there is great potential for prevention in sports-related concussions. Several measures must be taken to avert the development of concussions in soccer and, when they take place, reduce their effects. These include the development and testing of effective equipment during play, the maintenance of regulatory standards for all such equipment, educating young athletes on the safe and appropriate techniques used during play, and strict adherence to the rules of competition. In spite of such preventive measures, concussions in soccer will continue to occur. Considering the frequency of concussions in soccer, the serious sequelae of

  14. Gliomatosis Cerebri: Current Understanding and Controversies

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    Surabhi Ranjan

    2017-08-01

    Full Text Available Gliomatosis cerebri (GC is a rare, extensively infiltrating glioma involving multiple contiguous lobes of the brain. This lethal disease affects all age groups, and the majority of patients have a poor outcome despite aggressive treatment. Despite its initial recognition in 1938, GC remains a controversial entity with little consensus in its definition, histology, or treatment. The majority of GC tumors are astrocytic, although mixed phenotypes have been identified. Treatment of GC is challenging as surgery is generally not an option due to the extensive areas of brain involved, the benefit of radiation therapy is unclear, and no chemotherapy has proven efficacy. Due to the rarity of the disease and its heterogeneity, both at histopathological and molecular levels, it is difficult to conduct clinical trials tailored for this diagnosis. This review summarizes our current knowledge, examines clinical studies focusing on the treatment of GC, highlights ongoing challenges, and discusses the recent molecular insights into adult and pediatric GC. We conclude that, although no longer recognized as a distinct pathological entity, GC represents a unique disease phenotype. Given the histologic and molecular overlap with other diffuse gliomas, the research emphasis should be on investigating its unique invasive biology.

  15. Cirrhosis and autoimmune liver disease: Current understanding

    Science.gov (United States)

    Liberal, Rodrigo; Grant, Charlotte R

    2016-01-01

    Primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) constitute the classic autoimmune liver diseases (AILDs). While AIH target the hepatocytes, in PBC and PSC the targets of the autoimmune attack are the biliary epithelial cells. Persistent liver injury, associated with chronic AILD, leads to un-resolving inflammation, cell proliferation and the deposition of extracellular matrix proteins by hepatic stellate cells and portal myofibroblasts. Liver cirrhosis, and the resultant loss of normal liver function, inevitably ensues. Patients with cirrhosis have higher risks or morbidity and mortality, and that in the decompensated phase, complications of portal hypertension and/or liver dysfunction lead to rapid deterioration. Accurate diagnosis and monitoring of cirrhosis is, therefore of upmost importance. Liver biopsy is currently the gold standard technique, but highly promising non-invasive methodology is under development. Liver transplantation (LT) is an effective therapeutic option for the management of end-stage liver disease secondary to AIH, PBC and PSC. LT is indicated for AILD patients who have progressed to end-stage chronic liver disease or developed intractable symptoms or hepatic malignancy; in addition, LT may also be indicated for patients presenting with acute liver disease due to AIH who do not respond to steroids. PMID:27729952

  16. Understanding current causes of women's underrepresentation in science.

    Science.gov (United States)

    Ceci, Stephen J; Williams, Wendy M

    2011-02-22

    Explanations for women's underrepresentation in math-intensive fields of science often focus on sex discrimination in grant and manuscript reviewing, interviewing, and hiring. Claims that women scientists suffer discrimination in these arenas rest on a set of studies undergirding policies and programs aimed at remediation. More recent and robust empiricism, however, fails to support assertions of discrimination in these domains. To better understand women's underrepresentation in math-intensive fields and its causes, we reprise claims of discrimination and their evidentiary bases. Based on a review of the past 20 y of data, we suggest that some of these claims are no longer valid and, if uncritically accepted as current causes of women's lack of progress, can delay or prevent understanding of contemporary determinants of women's underrepresentation. We conclude that differential gendered outcomes in the real world result from differences in resources attributable to choices, whether free or constrained, and that such choices could be influenced and better informed through education if resources were so directed. Thus, the ongoing focus on sex discrimination in reviewing, interviewing, and hiring represents costly, misplaced effort: Society is engaged in the present in solving problems of the past, rather than in addressing meaningful limitations deterring women's participation in science, technology, engineering, and mathematics careers today. Addressing today's causes of underrepresentation requires focusing on education and policy changes that will make institutions responsive to differing biological realities of the sexes. Finally, we suggest potential avenues of intervention to increase gender fairness that accord with current, as opposed to historical, findings.

  17. Understanding current causes of women's underrepresentation in science

    Science.gov (United States)

    Williams, Wendy M.

    2011-01-01

    Explanations for women's underrepresentation in math-intensive fields of science often focus on sex discrimination in grant and manuscript reviewing, interviewing, and hiring. Claims that women scientists suffer discrimination in these arenas rest on a set of studies undergirding policies and programs aimed at remediation. More recent and robust empiricism, however, fails to support assertions of discrimination in these domains. To better understand women's underrepresentation in math-intensive fields and its causes, we reprise claims of discrimination and their evidentiary bases. Based on a review of the past 20 y of data, we suggest that some of these claims are no longer valid and, if uncritically accepted as current causes of women's lack of progress, can delay or prevent understanding of contemporary determinants of women's underrepresentation. We conclude that differential gendered outcomes in the real world result from differences in resources attributable to choices, whether free or constrained, and that such choices could be influenced and better informed through education if resources were so directed. Thus, the ongoing focus on sex discrimination in reviewing, interviewing, and hiring represents costly, misplaced effort: Society is engaged in the present in solving problems of the past, rather than in addressing meaningful limitations deterring women's participation in science, technology, engineering, and mathematics careers today. Addressing today's causes of underrepresentation requires focusing on education and policy changes that will make institutions responsive to differing biological realities of the sexes. Finally, we suggest potential avenues of intervention to increase gender fairness that accord with current, as opposed to historical, findings. PMID:21300892

  18. Between understanding and appreciation. Current science communication in Denmark

    Directory of Open Access Journals (Sweden)

    Kristian Hvidtfelt Nielsen

    2005-12-01

    Full Text Available In this paper I use the concepts “understanding of science” and “appreciation of science” to analyze selected case studies of current science communication in Denmark. The Danish science communication system has many similarities with science communication in other countries: the increasing political and scientific interest in science communication, the co-existence of many different kinds of science communication, and the multiple uses of the concepts of understanding vs. appreciation of science. I stress the international aspects of science communication, the national politico-scientific context as well as more local contexts as equally important conditions for understanding current Danish science communication.

  19. Suggestibility, expectancy, trance state effects, and hypnotic depth: I. Implications for understanding hypnotism.

    Science.gov (United States)

    Pekala, Ronald J; Kumar, V K; Maurer, Ronald; Elliott-Carter, Nancy; Moon, Edward; Mullen, Karen

    2010-04-01

    This paper reviews the relationships between trance or altered state effects, suggestibility, and expectancy as these concepts are defined in the theorizing of Weitzenhoffer (2002), Holroyd (2003), Kirsch (1991), and others, for the purpose of demonstrating how these concepts can be assessed with the PCI-HAP (Phenomenology of Consciousness Inventory: Hypnotic Assessment Procedure; Pekala, 1995a, b). In addition, how the aforementioned variables may relate to the nature of hypnosis/hypnotism as a function of self-reported hypnotic depth are discussed, along with how the PCI-HAP may be used as a means to measure hypnotic responsivity from a more phenomenological state perspective, in contrast to more traditional behavioral trait assessment instruments like the Harvard, the Stanford C, or the HIP. A follow-up paper (Pekala, Kumar, Maurer, Elliott-Carter, Moon, & Mullen, 2010) will present research data on the PCI-HAP model and how this model can be useful for better understanding hypnotism.

  20. Between understanding and appreciation. Current science communication in Denmark

    OpenAIRE

    Kristian Hvidtfelt Nielsen.

    2005-01-01

    In this paper I use the concepts “understanding of science” and “appreciation of science” to analyze selected case studies of current science communication in Denmark. The Danish science communication system has many similarities with science communication in other countries: the increasing political and scientific interest in science communication, the co-existence of many different kinds of science communication, and the multiple uses of the concepts of understanding vs. appreciation of sci...

  1. Meteorological Conditions Causing Jet-Engine Poweloss Events: Current Understanding

    Science.gov (United States)

    Strapp, J. W.; Ratvasky, T. P.

    2009-09-01

    The aviation industry is currently investigating a regular occurrence of jet engine-powerloss events which have now been attributed to the ingestion of atmospheric ice particles, usually in the vicinity of deep convection. There is a limited amount of information on the cloud microphysical properties near the cores of deep convection due to the potential hazards of flying in these areas, and due to the fact that it is a very challenging environment for current instrumentation. Most of the information that has been used to deduce the details of the conditions that cause engine powerloss has been extracted from the event-aircraft flight data recorders, pilot interviews, ground radar and satellite, a series of flight test programs in the 1950s and again in the 1990s, and the most recently available limited data from the cloud physics community. These have led to the conclusion that engine events occur due to flight through high mass concentrations of ice particles, probably with ice water contents (IWCs) in excess of 2 grams per cubic meter, and perhaps as high as 8. The limited microphysical data available has been used to suggest a median mass diameter of the ice particles of ~200 microns, with some evidence that it may be as low as 40 microns. These small particle sizes in the presence of high mass concentration is consistent with the lack of radar echoes > 20 dBZ observed on the pilot's radar, a consistent observation during engine events. The Engine Harmonization Working Group, an industry/regulator/government committee investigating engine powerloss, has concluded that the level of understanding of the properties of these clouds is inadequate to provide guidance to industry for engine design and testing. In order to address this issue, NASA and Environment Canada are planning to instrument an aircraft to make measurements in high IWC regions of tropical monsoon and continental convection. There is also a significant effort to upgrade and develop new

  2. Culture Teaching in China’s Current College English Class and Some Suggestions

    Institute of Scientific and Technical Information of China (English)

    李思远

    2014-01-01

    Culture is an important part in foreign language learning because no language can leave its culture contexts. Therefore, if one wants to learn a foreign language well, the acculturation is very important. But in the Chinese EFL classroom, for kinds of reasons, teachers often pay more attention to the explanation of grammatical rules and ignored the culture input which makes many Chinese students lack of pragmatic competence and can not use English in a proper way. This article will analyze the cur-rent culture teaching in our college English class and propose some suggestions.

  3. Current demographics suggest future energy supplies will be inadequate to slow human population growth.

    Directory of Open Access Journals (Sweden)

    John P DeLong

    Full Text Available Influential demographic projections suggest that the global human population will stabilize at about 9-10 billion people by mid-century. These projections rest on two fundamental assumptions. The first is that the energy needed to fuel development and the associated decline in fertility will keep pace with energy demand far into the future. The second is that the demographic transition is irreversible such that once countries start down the path to lower fertility they cannot reverse to higher fertility. Both of these assumptions are problematic and may have an effect on population projections. Here we examine these assumptions explicitly. Specifically, given the theoretical and empirical relation between energy-use and population growth rates, we ask how the availability of energy is likely to affect population growth through 2050. Using a cross-country data set, we show that human population growth rates are negatively related to per-capita energy consumption, with zero growth occurring at ∼13 kW, suggesting that the global human population will stop growing only if individuals have access to this amount of power. Further, we find that current projected future energy supply rates are far below the supply needed to fuel a global demographic transition to zero growth, suggesting that the predicted leveling-off of the global population by mid-century is unlikely to occur, in the absence of a transition to an alternative energy source. Direct consideration of the energetic constraints underlying the demographic transition results in a qualitatively different population projection than produced when the energetic constraints are ignored. We suggest that energetic constraints be incorporated into future population projections.

  4. Modelling Monsoons: Understanding and Predicting Current and Future Behaviour

    Energy Technology Data Exchange (ETDEWEB)

    Turner, A; Sperber, K R; Slingo, J M; Meehl, G A; Mechoso, C R; Kimoto, M; Giannini, A

    2008-09-16

    including, but not limited to, the Mei-Yu/Baiu sudden onset and withdrawal, low-level jet orientation and variability, and orographic forced rainfall. Under anthropogenic climate change many competing factors complicate making robust projections of monsoon changes. Without aerosol effects, increased land-sea temperature contrast suggests strengthened monsoon circulation due to climate change. However, increased aerosol emissions will reflect more solar radiation back to space, which may temper or even reduce the strength of monsoon circulations compared to the present day. A more comprehensive assessment is needed of the impact of black carbon aerosols, which may modulate that of other anthropogenic greenhouse gases. Precipitation may behave independently from the circulation under warming conditions in which an increased atmospheric moisture loading, based purely on thermodynamic considerations, could result in increased monsoon rainfall under climate change. The challenge to improve model parameterizations and include more complex processes and feedbacks pushes computing resources to their limit, thus requiring continuous upgrades of computational infrastructure to ensure progress in understanding and predicting the current and future behavior of monsoons.

  5. Current Situation and Suggestions of Decorative Fishery Development in Hainan Province

    Institute of Scientific and Technical Information of China (English)

    Xi; ZHANG; Ning; YANG; Hai; HUANG

    2013-01-01

    Decorative fishery is an important part of recreational fisheries,Hainan has the potential to develop decorative fishery.In this paper,on the basis of the deep-going survey on the current situation of decorative fishery development in Hainan,the main questions of decorative fish cultivation and market were discussed.At the same time,many suggestions were brought up,such as exploiting the biological resources of Hainan Island,strengthening scientific research efforts,introducing new varieties of ornamental species,strengthening industrial guidance and market management,etc.,which will benefit the rational utilization of tropical biological resources and increase the whole competitive advantage of decorative fishery in Hainan Province.

  6. Current Understanding and Therapy of Asthma Workshop Summary

    Institute of Scientific and Technical Information of China (English)

    Kuender D. Yang; Yu-Zhi Chen; Shau-Ku Huang

    2004-01-01

    The prevalence of asthma has increased globally in the past 2 decades. To address this critical issue, a workshop on "Current Understanding and Therapy of Asthma" was recently held in Beijing, as a part of the 10th International Conference of the Society of Chinese Bioscientists in America (SCBA). Several pertinent topics were addressed by leading experts from China, Taiwan, Japan and the US, which include epidemiology, the molecular genetic mechanism, pathogenesis, treatment and prevention of asthma. This article highlights the issues presented and discussed in this ground-breaking symposium emphasizing this important public health problem in the Chinese population. Cellular & Molecular Immunology. 2004;1(6):436-439.

  7. Current Understanding and Therapy of Asthma Workshop Summary

    Institute of Scientific and Technical Information of China (English)

    KuenderD.Yangt; Yu-ZhiChen; Shau-KuHuang

    2004-01-01

    The prevalence of asthma has increased globally in the past 2 decades. To address this critical issue, a workshop on “Current Understanding and Therapy of Asthma” was recently held in Beijing, as a part of the 10th International Conference of the Society of Chinese Bioscientists in America (SCBA). Several pertinent topics were addressed by leading experts from China, Taiwan, Japan and the US, which include epidemiology, the molecular genetic mechanism, pathogenesis, treatment and prevention of asthma. This article highlights the issues presented and discussed in this ground-breaking symposium emphasizing this important public health problem in the Chinese population. Cellular & Molecular Immunology. 2004;1(6):436-439.

  8. Uncertainty of current understanding regarding OBT formation in plants

    CERN Document Server

    Melintescu, Anca

    2016-01-01

    The radiological impact models are important tools for supporting nuclear safety. For tritium, a special radionuclide entering the life cycle, the processes involved in its transport into the environment are complex and not well enough understood. The tritiated water (HTO) enters the plants by atmospheric and root pathway and is converted to organically bound tritium (OBT) in exchangeable and non-exchangeable forms. The observed OBT/HTO ratios in crops exhibit a large variability and contradict the current models for routine releases. If a spike release (i.e. short time but intense atmospheric release higher than the normal release rate) occurs during routine emission, the dose to public is higher than for normal routine emission. The experimental data for a short and intense atmospheric contamination of wheat are presented together with the models predictions. Although the current understanding of processes involved in OBT formation in plants is still insufficient, considering the non-equilibrium situation i...

  9. Suggestions to Gain Deeper Understanding of Magnetic Fields in Astrophysics Classrooms

    Science.gov (United States)

    Woolsey, Lauren N.

    2016-01-01

    I present two tools that could be used in an undergraduate or graduate classroom to aid in developing intuition of magnetic fields, how they are measured, and how they affect large scale phenomena like the solar wind. The first tool is a Mathematica widget I developed that simulates observations of magnetic field in the Interstellar Medium (ISM) using the weak Zeeman effect. Woolsey (2015, JAESE) discusses the relevant background information about what structures in the ISM produce a strong enough effect and which molecules are used to make the measurement and why. This widget could be used in an entry level astronomy course as a way to show how astronomers actually make certain types of measurements and allow students to practice inquiry-based learning to understand how different aspects of the ISM environment strengthen or weaken the observed signal. The second tool is a Python model of the solar wind, The Efficient Modified Parker Equation Solving Tool (TEMPEST), that is publicly available on GitHub (https://github.com/lnwoolsey/tempest). I discuss possible short-term projects or investigations that could be done using the programs in the TEMPEST library that are suitable for upper-level undergraduates or in graduate level coursework (Woolsey, 2015, JRAEO).

  10. The current state of public understanding of nanotechnology

    Energy Technology Data Exchange (ETDEWEB)

    Waldron, Anna M [Cornell University, Nanobiotechnology Center (United States)], E-mail: amw37@cornell.edu; Spencer, Douglas [Edu, Inc. (United States); Batt, Carl A [Cornell University (United States)

    2006-10-15

    The growing importance of nanotechnology in industry and society has not been accompanied by a widespread understanding of the subject among the general public. Simple questions to initially probe the smallest thing that people can see and can think of reveals a divide in the understanding of the general public. A survey of 1500 individuals ranging in age from 6 to 74 has revealed a lack of knowledge of nanotechnology and especially a lack of understanding of the context of nanotechnology in the world that is too small to see. Survey findings are corroborated by in-depth interviews with 400 adults in studies of nanoscience literacy commisioned by University of California, Berkeley and Cornell in 2002 and 2004, respectively. In general, with the exception of 14-28 year olds, over 60% of respondents say they have never heard of nano or nanotechnology. The results suggest that the general public, especially middle-school children, has no firm foundation to understand nanotechnology and likely will continue to be equally impressed by credible scientific information as well as pure fictional accounts of nanotechnology.

  11. Current understanding of organically bound tritium (OBT) in the environment.

    Science.gov (United States)

    Kim, S B; Baglan, N; Davis, P A

    2013-12-01

    It has become increasingly recognized that organically bound tritium (OBT) is the more significant tritium fraction with respect to understanding tritium behaviour in the environment. There are many different terms associated with OBT; such as total OBT, exchangeable OBT, non-exchangeable OBT, soluble OBT, insoluble OBT, tritiated organics, and buried tritium, etc. A simple classification is required to clarify understanding within the tritium research community. Unlike for tritiated water (HTO), the environmental quantification and behaviour of OBT are not well known. Tritiated water cannot bio-accumulate in the environment. However, it is not clear whether or not this is the case for OBT. Even though OBT can be detected in terrestrial biological materials, aquatic biological materials and soil samples, its behaviour is still in question. In order to evaluate the radiation dose from OBT accurately, further study will be required to understand OBT measurements and determine OBT fate in the environment. The relationship between OBT speciation and the OBT/HTO ratio in environmental samples will be useful in this regard, providing information on the previous tritium exposure conditions in the environment and the current tritium dynamics. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.

  12. Pressure ulcers: Current understanding and newer modalities of treatment

    Science.gov (United States)

    Bhattacharya, Surajit; Mishra, R. K.

    2015-01-01

    This article reviews the mechanism, symptoms, causes, severity, diagnosis, prevention and present recommendations for surgical as well as non-surgical management of pressure ulcers. Particular focus has been placed on the current understandings and the newer modalities for the treatment of pressure ulcers. The paper also covers the role of nutrition and pressure-release devices such as cushions and mattresses as a part of the treatment algorithm for preventing and quick healing process of these wounds. Pressure ulcers develop primarily from pressure and shear; are progressive in nature and most frequently found in bedridden, chair bound or immobile people. They often develop in people who have been hospitalised for a long time generally for a different problem and increase the overall time as well as cost of hospitalisation that have detrimental effects on patient's quality of life. Loss of sensation compounds the problem manifold, and failure of reactive hyperaemia cycle of the pressure prone area remains the most important aetiopathology. Pressure ulcers are largely preventable in nature, and their management depends on their severity. The available literature about severity of pressure ulcers, their classification and medical care protocols have been described in this paper. The present treatment options include various approaches of cleaning the wound, debridement, optimised dressings, role of antibiotics and reconstructive surgery. The newer treatment options such as negative pressure wound therapy, hyperbaric oxygen therapy, cell therapy have been discussed, and the advantages and disadvantages of current and newer methods have also been described. PMID:25991879

  13. Pressure ulcers: Current understanding and newer modalities of treatment

    Directory of Open Access Journals (Sweden)

    Surajit Bhattacharya

    2015-01-01

    Full Text Available This article reviews the mechanism, symptoms, causes, severity, diagnosis, prevention and present recommendations for surgical as well as non-surgical management of pressure ulcers. Particular focus has been placed on the current understandings and the newer modalities for the treatment of pressure ulcers. The paper also covers the role of nutrition and pressure-release devices such as cushions and mattresses as a part of the treatment algorithm for preventing and quick healing process of these wounds. Pressure ulcers develop primarily from pressure and shear; are progressive in nature and most frequently found in bedridden, chair bound or immobile people. They often develop in people who have been hospitalised for a long time generally for a different problem and increase the overall time as well as cost of hospitalisation that have detrimental effects on patient′s quality of life. Loss of sensation compounds the problem manifold, and failure of reactive hyperaemia cycle of the pressure prone area remains the most important aetiopathology. Pressure ulcers are largely preventable in nature, and their management depends on their severity. The available literature about severity of pressure ulcers, their classification and medical care protocols have been described in this paper. The present treatment options include various approaches of cleaning the wound, debridement, optimised dressings, role of antibiotics and reconstructive surgery. The newer treatment options such as negative pressure wound therapy, hyperbaric oxygen therapy, cell therapy have been discussed, and the advantages and disadvantages of current and newer methods have also been described.

  14. Spectroscopic observations of evolving flare ribbon substructure suggesting origin in current sheet waves

    Science.gov (United States)

    Brannon, Sean R.; Longcope, Dana; Qiu, Jiong

    2015-04-01

    A flare ribbon is the chromospheric image of reconnection at a coronal current sheet. The dynamics and structure of the ribbon can thus reveal properties of the current sheet, including motion of the reconnecting flare loops. We present imaging and spectroscopic observations from the Interface Region Imaging Spectrograph (IRIS) of the evolution of a flare ribbon at high spatial resolution and time cadence. These reveal small-scale substructure in the ribbon, which manifest as oscillations in both position and Doppler velocities. We consider various alternative explanations for these oscillations, including modulation of chromospheric evaporation flows. Among these we find the best support for some form of elliptical wave localized to the coronal current sheet, such as a tearing mode or Kelvin-Helmholtz instability.IRIS is a NASA Small Explorer mission developed and operated by Lockheed Martin Solar and Astrophysics Laboratory. This work is supported by contract 8100002702 from Lockheed Martin to Montana State University, a Montana Space Grant Consortium fellowship, and by NASA through HSR.

  15. Asthma in the Elderly: Current Understanding and Future Research Needs

    Science.gov (United States)

    Hanania, Nicola A.; King, Monroe J.; Braman, Sidney S.; Saltoun, Carol; Wise, Robert A.; Enright, Paul; Falsey, Ann A; Mathur, Sameer K.; Ramsdell, Joe W.; Rogers, Linda; Stempel, David A.; Lima, John J.; Fish, James E.; Wilson, Sandra R.; Boyd, Cynthia; Patel, Kushang V.; Irvin, Charles G.; Yawn, Barbara P.; Halm, Ethan A; Wasserman, Stephen I.; Sands, Mark F.; Ershler, William B.; Ledford, Dennis K.

    2011-01-01

    Asthma in the elderly (AIE) is under diagnosed and under treated and there is a paucity of knowledge. The National Institute on Aging convened this workshop to identify what is known, what gaps in knowledge remain and suggest research directions needed to improve the understanding and care of AIE. Asthma presenting at an advanced age often has similar clinical and physiologic consequences as seen with younger individuals but co-morbid illnesses and the psychosocial effects of aging may affect the diagnosis, clinical presentation and care of asthma in this population. At least two phenotypes exist among elderly asthma; those with long-standing asthma have more severe airflow limitation and less complete reversibility than those with late-onset asthma. Many challenges exist in the recognition and treatment of asthma in the elderly. Furthermore, the pathophysiological mechanisms of AIE are likely to be different from those seen in young asthmatics and these differences may influence the clinical course and outcomes of asthma in this population. PMID:21872730

  16. Catatonia: Our current understanding of its diagnosis, treatment and pathophysiology

    Science.gov (United States)

    Rasmussen, Sean A; Mazurek, Michael F; Rosebush, Patricia I

    2016-01-01

    Catatonia is a psychomotor syndrome that has been reported to occur in more than 10% of patients with acute psychiatric illnesses. Two subtypes of the syndrome have been identified. Catatonia of the retarded type is characterized by immobility, mutism, staring, rigidity, and a host of other clinical signs. Excited catatonia is a less common presentation in which patients develop prolonged periods of psychomotor agitation. Once thought to be a subtype of schizophrenia, catatonia is now recognized to occur with a broad spectrum of medical and psychiatric illnesses, particularly affective disorders. In many cases, the catatonia must be treated before any underlying conditions can be accurately diagnosed. Most patients with the syndrome respond rapidly to low-dose benzodiazepines, but electroconvulsive therapy is occasionally required. Patients with longstanding catatonia or a diagnosis of schizophrenia may be less likely to respond. The pathobiology of catatonia is poorly understood, although abnormalities in gamma-aminobutyric acid and glutamate signaling have been suggested as causative factors. Because catatonia is common, highly treatable, and associated with significant morbidity and mortality if left untreated, physicians should maintain a high level of suspicion for this complex clinical syndrome. Since 1989, we have systematically assessed patients presenting to our psychiatry service with signs of retarded catatonia. In this paper, we present a review of the current literature on catatonia along with findings from the 220 cases we have assessed and treated. PMID:28078203

  17. Catatonia: Our current understanding of its diagnosis, treatment and pathophysiology.

    Science.gov (United States)

    Rasmussen, Sean A; Mazurek, Michael F; Rosebush, Patricia I

    2016-12-22

    Catatonia is a psychomotor syndrome that has been reported to occur in more than 10% of patients with acute psychiatric illnesses. Two subtypes of the syndrome have been identified. Catatonia of the retarded type is characterized by immobility, mutism, staring, rigidity, and a host of other clinical signs. Excited catatonia is a less common presentation in which patients develop prolonged periods of psychomotor agitation. Once thought to be a subtype of schizophrenia, catatonia is now recognized to occur with a broad spectrum of medical and psychiatric illnesses, particularly affective disorders. In many cases, the catatonia must be treated before any underlying conditions can be accurately diagnosed. Most patients with the syndrome respond rapidly to low-dose benzodiazepines, but electroconvulsive therapy is occasionally required. Patients with longstanding catatonia or a diagnosis of schizophrenia may be less likely to respond. The pathobiology of catatonia is poorly understood, although abnormalities in gamma-aminobutyric acid and glutamate signaling have been suggested as causative factors. Because catatonia is common, highly treatable, and associated with significant morbidity and mortality if left untreated, physicians should maintain a high level of suspicion for this complex clinical syndrome. Since 1989, we have systematically assessed patients presenting to our psychiatry service with signs of retarded catatonia. In this paper, we present a review of the current literature on catatonia along with findings from the 220 cases we have assessed and treated.

  18. The rings of Saturn: State of current knowledge and some suggestions for future studies

    Science.gov (United States)

    Cuzzi, J. N.

    1978-01-01

    The state of our current knowledge of the properties of the ring system as a whole, and of the particles individually, is assessed. Attention is primarily devoted to recent results and possibilities for exploration of the ring system by a Saturn orbiter. In particular, the infrared and microwave properties of the ring system are discussed. The behavior of the ring brightness is not well understood in the critical transition spectral region from approximately 100 micrometers to approximately 1 cm. Also, the dynamical behavior of the ring system is discussed. Recent theoretical studies show that ongoing dynamical effects continually affect the ring structure in azimuth (possibly producing the A ring brightness asymmetry) and in the vertical direction. Orbital spacecraft-based studies of the rings will offer several unique advantages and impact important cosmogonical questions. Bistatic radar studies and millimeter-wavelength spectrometer/radiometry will give particle sizes and composition limits needed to resolve the question of the density of the rings, and provide important boundary conditions on the state of Saturn's protoplanetary nebula near the time of planetary formation.

  19. Mechanisms and Kinetics of Environmentally Assisted Cracking: Current Status, Issues, and Suggestions for Further Work

    Science.gov (United States)

    Lynch, S. P.

    2013-03-01

    Mechanisms and kinetics of metal-induced embrittlement, hydrogen-embrittlement, and stress-corrosion cracking are discussed, and long-standing controversies are addressed by reviewing critical observations. Recommendations are also made regarding further work (including repetition of previous work using more advanced measurement and characterisation techniques) that should be carried out in order to resolve some of the contentious issues. The evidence to date suggests that adsorption-based mechanisms, involving weakening of substrate interatomic bonds so that dislocation emission or decohesion is facilitated, accounts for embrittlement in many systems. Embrittling adsorbed species include some metal atoms, hydrogen, and complex ions produced by de-alloying. Other viable mechanisms of embrittlement include those based on (1) dissolution of anodic grain-boundary regions, and (2) decohesion at grain boundaries owing to segregated hydrogen and impurities. The hydrogen-enhanced localised-plasticity mechanism, based on solute hydrogen facilitating dislocation activity in the plastic zone ahead of cracks, makes a contribution in some cases, but is relatively unimportant compared with these other mechanisms for most fracture modes. The film-induced cleavage mechanism, proposed especially for stress-corrosion cracking in systems involving de-alloying at crack tips, is questionable on numerous grounds, and is probably not viable. Rate-controlling processes for environmentally assisted cracking are not well established, except for solid-metal induced embrittlement where surface self-diffusion of embrittling atoms to crack tips controls cracking kinetics. In some systems, adsorption kinetics are probably rate-controlling for liquid-metal embrittlement, hydrogen-environment embrittlement, and stress-corrosion cracking. In other cases, rate-controlling processes could include the rate of anodic or cathodic reactions at and behind crack tips (responsible for producing embrittling

  20. Hepatitis B Vaccination in Bangladesh: a Suggestion Based on Current Evidence

    Directory of Open Access Journals (Sweden)

    Shafquat Mohammed Rafiq

    2006-12-01

    Full Text Available IntroductionThe hepatitis B virus (HBV causes up to a million deaths worldwide and 16 million health care related infections in the tropics each year(1,2, and over 350 million become chronically infected carriers who have no significant liver disease; approximately three quarters of them are in Asia and the western pacific region(3,4. HBV infection is a potentially life threatening condition as many of the affected individuals progress to chronic hepatitis,cirrhosis and hepatocellular carcinoma (HCC(3. In infants and children, acute hepatitis B infection is nearly always asymptomatic, whereas in adults it is usually the opposite. But on the other hand, the risk of becoming chronic carriage is much greater in children than in adults; as many as 90% of infants born to Hepatitis B e Antigen (HBeAg positive mothers become carriers themselves and, therefore, in long term are more likely to developchronic liver disease(5. Currently, though several antiviral drugs are used,there is no reliable curative treatment for HBV once it has been acquired and prevention by universal immunization remains the strategy for reducing the number of acute infections, chronic carriage and the long-term burden from diseases such as HCC(4,6. In 1991, in an attempt to reduce the global impact of HBV infection, WHO recommended that hepatitis B vaccination should be integrated into national immunization programs in all countries(7.Some Asian countries, for instance, Thailand, haveadopted the policy of immunizing children universally against the disease as early as 1992, however many others lagged behind(4.The true prevalence of Hepatitis B in Bangladesh is yet to be ascertained by a reliable study. Data available from different studies show that it ranges between 0.8 and 5.4% depending on the study design, samples and laboratory methods used(8-10.These data were based on detection of HBsAg antigen; the rates would have been higher, had they been based on anti-HBc antibody(11

  1. 16 CFR Figures 1 and 2 to Part 1204 - Suggested Instrumentation for Current Monitoring Device and High Voltage Facility

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Suggested Instrumentation for Current Monitoring Device and High Voltage Facility 1 Figures 1 and 2 to Part 1204 Commercial Practices CONSUMER... Instrumentation for Current Monitoring Device and High Voltage Facility EC03OC91.008...

  2. [Idiopathic epiretinal membrane: definition, classification, current understanding of pathogenesis].

    Science.gov (United States)

    Ponomareva, E N; Kazarian, A A

    2014-01-01

    Idiopathic epiretinal membrane is a result of a complex biomechanical interaction of the retina and vitreous. This paper discusses classification problems, epidemiological data of multicenter studies, and current hypotheses of epiretinal membrane pathogenesis.

  3. Current Approaches to the Understanding of Early Infantile Autism.

    Science.gov (United States)

    Rickman, David L.

    This review of the literature provides summaries of the genetic, neurophysiological, and biochemical approaches to understanding autism, with special reference to neuroanatomic, cognitive, and neuropsychological studies of this disorder. Available instruments for the assessment of autism and various treatment alternatives including drug therapy,…

  4. Current understanding of the neuropathophysiology of pain in chronic pancreatitis

    Institute of Scientific and Technical Information of China (English)

    Amporn; Atsawarungruangkit; Supot; Pongprasobchai

    2015-01-01

    Chronic pancreatitis(CP) is a chronic inflammatory disease of the pancreas. The main symptom of patients with CP is chronic and severe abdominal pain. However, the pathophysiology of pain in CP remains obscure.Traditionally, researchers believed that the pain was caused by anatomical changes in pancreatic structure. However, treatment outcomes based on such beliefs are considered unsatisfactory. The emerging explanations of pain in CP are trending toward neurobiological theories. This article aims to review current evidence regarding the neuropathophysiology of pain in CP and its potential implications for the development of new treatments for pain in CP.

  5. Current understanding of the neurobiology of major depressive disorder.

    Science.gov (United States)

    Chiriţă, Anca Livia; Gheorman, Victor; Bondari, Dan; Rogoveanu, Ion

    2015-01-01

    Depression is highly prevalent worldwide and associated with significant morbidity and mortality. Approximately 340 million people worldwide suffer from depression at any given time. Based on estimates from the World Health Organization (WHO), depression is responsible for the greatest proportion of burden associated with non-fatal health outcomes and accounts for approximately 12% total years lived with disability. Probably no single risk factor can be completely isolated in major depressive disorder (MDD), as interactions between many sources of vulnerability are the most likely explanation. Buttressing the identification of grief, demoralization, hopelessness and styles of psychological coping of the depressed patient are vital, ongoing scientific developments that flow from an increased understanding of this interplay amongst the immune system, endocrine system and brain. The rapidly accumulating body of neurobiological knowledge has catalyzed fundamental changes in how we conceptualize depressive symptoms and has important implications regarding the treatment and even prevention of depressive symptoms in patients.

  6. International migration flows. Framework for understanding and current features.

    Directory of Open Access Journals (Sweden)

    Colectivo IOÉ

    2016-10-01

    Full Text Available The present article aims to outline a framework for the understanding of the present international migratory flows as well as to outline their main traits. In order to do this, we first group together the different migratory flows produced since the sixteenth century up to the mid seventies in the twentieth  century, stopping then for a closer look at the present situation which register the impact of economic globalization, translating it into an increase of said flows and, above all, to their enormous diversification. To end, we make a brief balance of the present period and a critical evaluation on the meaning of one of the flows which attracts most attention, economic migrations south-north, because these are the ones which have the most impact on developed countries.

  7. Sill induced hydrothermal venting: A summary of our current understanding

    Science.gov (United States)

    Jerram, Dougal; Svenesn, Henrik; Planke, Sverre; Millett, John; Reynolds, Pete

    2017-04-01

    Hydrothermal vent structures which are predominantly related with the emplacement of large (>1000 km3) intrusions into the sub-volcanic basins represent a specific style of piercement structure, where climate-forcing gases can be transferred into the atmosphere and hydrosphere. In this case, the types and volumes of gas produced by intrusions is heavily dependent on the host-rock sediment properties that they intrude through. The distribution of vent structures can be shown to be widespread in Large Igneous Provinces for example on both the Norwegian and the Greenland margins of the North Atlantic Igneous Province (NAIP). In this overview we assess the distribution, types and occurrence of hydrothermal vent structures associated with LIPs. There is particular focus on those within the NAIP using mapped examples from offshore seismic data as well as outcrop analogues, highlighting the variability of these structures and their deposits. As the availability of 3D data from offshore and onshore increases, the full nature of the volcanic stratigraphy from the subvolcanic intrusive complexes, through the main eruption cycles into the piercing vent structures, can be realised along the entirety of volcanic rifted margins and LIPs. This will help greatly in our understanding of the evolving palaeo-environments, and climate contributions during the evolution of these short lived massive volcanic events.

  8. The Vaginal Microbiome: Current Understanding and Future Directions.

    Science.gov (United States)

    Martin, David H; Marrazzo, Jeanne M

    2016-08-15

    This article summarizes the highlights of the expert technical consultation on bacterial vaginosis (BV), sponsored by the National Institute of Allergy and Infectious Disease and held in Washington, DC, on 8-9 April 2015. Many issues touched on in this article are discussed in much greater detail in the 6 preceding articles in this supplement to The Journal of Infectious Diseases There was a consensus among the meeting attendees concerning the most important research issues in the field: the pathogenesis of the syndrome, way to optimize treatment, and the relative roles of sexual transmission and endogenous infection in BV epidemiology. This article concludes with a listing of BV and genitourinary tract research priorities that were discussed and agreed on by attendees. The most important of these included better characterization of vaginal microbiome community state subtypes, application of advanced "-omic" technologies to improve understanding of BV pathogenesis, further investigation of the relationships between the male and female genitourinary tract microbiomes, and the development of new drugs for BV treatment. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

  9. The autophagosome: current understanding of formation and maturation

    Directory of Open Access Journals (Sweden)

    Mannack LVJC

    2015-02-01

    Full Text Available Lilith VJC Mannack, Jon D Lane Cell Biology Laboratories, School of Biochemistry, University of Bristol, Bristol, UK Abstract: Autophagy is an important and highly conserved catabolic process with roles in development, homeostasis, and cellular stress responses. It describes various distinct pathways for the delivery of cytoplasmic materials (including misfolded protein aggregates and some organelles to the lysosome for degradation and component recycling. The best understood form of autophagy (macroautophagy describes the de novo assembly, maturation, and trafficking of a unique double membrane-bound organelle – the autophagosomes – that sequesters cytoplasmic materials and ultimately merges with the lysosomal compartment to form a degradative autolysosome. To rapidly assemble such a structure in response to stimuli, cells express a family of dedicated autophagy-related (ATG gene products that act sequentially to control membrane events leading first to the nucleation of an isolation membrane or phagophore, followed by phagophore expansion, and sealing to form an autophagosome that traffics to – and ultimately fuses with – the lysosome. These molecules are activated in response to upstream signaling pathways (notably, the mechanistic target of rapamycin [mTOR] pathway, and comprise protein and lipid kinases, putative membrane coats, and unique ubiquitin-like conjugation systems. In concert, a barrage of accessory proteins involved in various membrane trafficking pathways focused on the endosomal compartment are co-opted at the assembly site to facilitate autophagosome biogenesis. Understanding the integrated pathways that coordinate autophagosome assembly at the molecular level will be crucial if we are to realize the potential for autophagy manipulation in future disease therapies. Keywords: autophagy, ATG proteins, lysosome, phagophore, omegasome, autolysosome, membrane trafficking, ULK1, mTOR, PI(3 kinase, PI3P, LIR motif

  10. Adjuvants to local anesthetics: Current understanding and future trends

    Science.gov (United States)

    Swain, Amlan; Nag, Deb Sanjay; Sahu, Seelora; Samaddar, Devi Prasad

    2017-01-01

    Although beneficial in acute and chronic pain management, the use of local anaesthetics is limited by its duration of action and the dose dependent adverse effects on the cardiac and central nervous system. Adjuvants or additives are often used with local anaesthetics for its synergistic effect by prolonging the duration of sensory-motor block and limiting the cumulative dose requirement of local anaesthetics. The armamentarium of local anesthetic adjuvants have evolved over time from classical opioids to a wide array of drugs spanning several groups and varying mechanisms of action. A large array of opioids ranging from morphine, fentanyl and sufentanyl to hydromorphone, buprenorphine and tramadol has been used with varying success. However, their use has been limited by their adverse effect like respiratory depression, nausea, vomiting and pruritus, especially with its neuraxial use. Epinephrine potentiates the local anesthetics by its antinociceptive properties mediated by alpha-2 adrenoreceptor activation along with its vasoconstrictive properties limiting the systemic absorption of local anesthetics. Alpha 2 adrenoreceptor antagonists like clonidine and dexmedetomidine are one of the most widely used class of local anesthetic adjuvants. Other drugs like steroids (dexamethasone), anti-inflammatory agents (parecoxib and lornoxicam), midazolam, ketamine, magnesium sulfate and neostigmine have also been used with mixed success. The concern regarding the safety profile of these adjuvants is due to its potential neurotoxicity and neurological complications which necessitate further research in this direction. Current research is directed towards a search for agents and techniques which would prolong local anaesthetic action without its deleterious effects. This includes novel approaches like use of charged molecules to produce local anaesthetic action (tonicaine and n butyl tetracaine), new age delivery mechanisms for prolonged bioavailability (liposomal

  11. Improving Understanding of the Agulhas Current and Its Global Climate Impacts

    Science.gov (United States)

    Beal, Lisa; Biastoch, Arne

    2010-05-01

    Working Group on the Climatic Importance of the Greater Agulhas System; Portland, Oregon, 20-21 February 2010; The first meeting of the new Scientific Committee on Oceanic Research (SCOR) Working Group 136 was held to discuss recent developments in understanding the greater Agulhas Current system and future research directions. The overarching goal of the working group is to improve understanding and awareness of the regional and global climate impacts of the Agulhas Current, a major western boundary current that flows along the east coast of Africa, and its interocean leakage. In addition to studying modern circulation, the working group is motivated by recent paleodata that suggest that through the currents' southern influence on the Atlantic meridional overturning circulation (AMOC), changes in the leakage of warm and salty Agulhas waters into the Atlantic may have triggered the end of ice ages. In terms of global climate, this arguably puts the importance of the greater Agulhas system on a par with Heinrich (land-ice release) events and high-latitude deepwater formation.

  12. Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities

    Science.gov (United States)

    Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities, a 2013 workshop sponsored by the Epidemiology and Genomics Research Program.

  13. Ecosystem services capacity across heterogeneous forest types: understanding the interactions and suggesting pathways for sustaining multiple ecosystem services.

    Science.gov (United States)

    Alamgir, Mohammed; Turton, Stephen M; Macgregor, Colin J; Pert, Petina L

    2016-10-01

    As ecosystem services supply from tropical forests is declining due to deforestation and forest degradation, much effort is essential to sustain ecosystem services supply from tropical forested landscapes, because tropical forests provide the largest flow of multiple ecosystem services among the terrestrial ecosystems. In order to sustain multiple ecosystem services, understanding ecosystem services capacity across heterogeneous forest types and identifying certain ecosystem services that could be managed to leverage positive effects across the wider bundle of ecosystem services are required. We sampled three forest types, tropical rainforests, sclerophyll forests, and rehabilitated plantation forests, over an area of 32,000m(2) from Wet Tropics bioregion, Australia, aiming to compare supply and evaluate interactions and patterns of eight ecosystem services (global climate regulation, air quality regulation, erosion regulation, nutrient regulation, cyclone protection, habitat provision, energy provision, and timber provision). On average, multiple ecosystem services were highest in the rainforests, lowest in sclerophyll forests, and intermediate in rehabilitated plantation forests. However, a wide variation was apparent among the plots across the three forest types. Global climate regulation service had a synergistic impact on the supply of multiple ecosystem services, while nutrient regulation service was found to have a trade-off impact. Considering multiple ecosystem services, most of the rehabilitated plantation forest plots shared the same ordination space with rainforest plots in the ordination analysis, indicating that rehabilitated plantation forests may supply certain ecosystem services nearly equivalent to rainforests. Two synergy groups and one trade-off group were identified. Apart from conserving rainforests and sclerophyll forests, our findings suggest two additional integrated pathways to sustain the supply of multiple ecosystem services from a

  14. Comprehensive Phenotyping in Multiple Sclerosis: Discovery Based Proteomics and the Current Understanding of Putative Biomarkers

    Directory of Open Access Journals (Sweden)

    Kevin C. O’Connor

    2006-01-01

    Full Text Available Currently, there is no single test for multiple sclerosis (MS. Diagnosis is confirmed through clinical evaluation, abnormalities revealed by magnetic resonance imaging (MRI, and analysis of cerebrospinal fluid (CSF chemistry. The early and accurate diagnosis of the disease, monitoring of progression, and gauging of therapeutic intervention are important but elusive elements of patient care. Moreover, a deeper understanding of the disease pathology is needed, including discovery of accurate biomarkers for MS. Herein we review putative biomarkers of MS relating to neurodegeneration and contributions to neuropathology, with particular focus on autoimmunity. In addition, novel assessments of biomarkers not driven by hypotheses are discussed, featuring our application of advanced proteomics and metabolomics for comprehensive phenotyping of CSF and blood. This strategy allows comparison of component expression levels in CSF and serum between MS and control groups. Examination of these preliminary data suggests that several CSF proteins in MS are differentially expressed, and thus, represent putative biomarkers deserving of further evaluation.

  15. Understandings of Current Environmental Issues: Turkish Case Study in Six Teacher Education Colleges

    Science.gov (United States)

    Cakir, Mustafa; Irez, Serhat; Dogan, Ozgur Kivilcan

    2010-01-01

    The purpose of this study is to profile future science teachers' understandings of current environmental issues in the context of an education reform in Turkey. Knowledge base and understandings of elementary and secondary prospective science teachers about biodiversity, carbon cycle, global warming and ozone layer depletion were targeted in the…

  16. Crucial knowledge gaps in current understanding of climate change impacts on coral reef fishes

    KAUST Repository

    Wilson, S. K.

    2010-02-26

    Expert opinion was canvassed to identify crucial knowledge gaps in current understanding of climate change impacts on coral reef fishes. Scientists that had published three or more papers on the effects of climate and environmental factors on reef fishes were invited to submit five questions that, if addressed, would improve our understanding of climate change effects on coral reef fishes. Thirty-three scientists provided 155 questions, and 32 scientists scored these questions in terms of: (i) identifying a knowledge gap, (ii) achievability, (iii) applicability to a broad spectrum of species and reef habitats, and (iv) priority. Forty-two per cent of the questions related to habitat associations and community dynamics of fish, reflecting the established effects and immediate concern relating to climate-induced coral loss and habitat degradation. However, there were also questions on fish demographics, physiology, behaviour and management, all of which could be potentially affected by climate change. Irrespective of their individual expertise and background, scientists scored questions from different topics similarly, suggesting limited bias and recognition of a need for greater interdisciplinary and collaborative research. Presented here are the 53 highest-scoring unique questions. These questions should act as a guide for future research, providing a basis for better assessment and management of climate change impacts on coral reefs and associated fish communities.

  17. Crucial knowledge gaps in current understanding of climate change impacts on coral reef fishes.

    Science.gov (United States)

    Wilson, S K; Adjeroud, M; Bellwood, D R; Berumen, M L; Booth, D; Bozec, Y-Marie; Chabanet, P; Cheal, A; Cinner, J; Depczynski, M; Feary, D A; Gagliano, M; Graham, N A J; Halford, A R; Halpern, B S; Harborne, A R; Hoey, A S; Holbrook, S J; Jones, G P; Kulbiki, M; Letourneur, Y; De Loma, T L; McClanahan, T; McCormick, M I; Meekan, M G; Mumby, P J; Munday, P L; Ohman, M C; Pratchett, M S; Riegl, B; Sano, M; Schmitt, R J; Syms, C

    2010-03-15

    Expert opinion was canvassed to identify crucial knowledge gaps in current understanding of climate change impacts on coral reef fishes. Scientists that had published three or more papers on the effects of climate and environmental factors on reef fishes were invited to submit five questions that, if addressed, would improve our understanding of climate change effects on coral reef fishes. Thirty-three scientists provided 155 questions, and 32 scientists scored these questions in terms of: (i) identifying a knowledge gap, (ii) achievability, (iii) applicability to a broad spectrum of species and reef habitats, and (iv) priority. Forty-two per cent of the questions related to habitat associations and community dynamics of fish, reflecting the established effects and immediate concern relating to climate-induced coral loss and habitat degradation. However, there were also questions on fish demographics, physiology, behaviour and management, all of which could be potentially affected by climate change. Irrespective of their individual expertise and background, scientists scored questions from different topics similarly, suggesting limited bias and recognition of a need for greater interdisciplinary and collaborative research. Presented here are the 53 highest-scoring unique questions. These questions should act as a guide for future research, providing a basis for better assessment and management of climate change impacts on coral reefs and associated fish communities.

  18. Between understanding and appreciation. Current science communication in Denmark (Danish original version

    Directory of Open Access Journals (Sweden)

    Kristian Hvidtfelt Nielsen

    2005-12-01

    Full Text Available In this paper I use the concepts “understanding of science” and “appreciation of science” to analyze selected case studies of current science communication in Denmark. The Danish science communication system has many similarities with science communication in other countries: the increasing political and scientific interest in science communication, the co-existence of many different kinds of science communication, and the multiple uses of the concepts of understanding vs. appreciation of science. I stress the international aspects of science communication, the national politico-scientific context as well as more local contexts as equally important conditions for understanding current Danish science communication.

  19. Understanding the Occurrence and Transport of Current-use Pesticides in the San Francisco Estuary Watershed

    OpenAIRE

    Kuivila, Kathryn; Hladik, Michelle

    2008-01-01

    The occurrence and potential effects of current-use pesticides are of concern in the San Francisco Estuary watershed but our understanding of the spatial and temporal distribution of contamination is limited. This paper summarizes almost two decades of historical data and uses it to describe our current knowledge of the processes controlling the occurrence of current-use pesticides in the watershed. Monitoring studies analyze fewer than half of the pesticides applied in the watershed and most...

  20. Current understanding of iberiotoxin-resistant BK channels in the nervous system.

    Science.gov (United States)

    Wang, Bin; Jaffe, David B; Brenner, Robert

    2014-01-01

    While most large-conductance, calcium-, and voltage-activated potassium channels (BK or Maxi-K type) are blocked by the scorpion venom iberiotoxin, the so-called "type II" subtype has the property of toxin resistance. This property is uniquely mediated by channel assembly with one member of the BK accessory β subunit family, the neuron-enriched β4 subunit. This review will focus on current understanding of iberiotoxin-resistant, β4-containing BK channel properties and their function in the CNS. Studies have shown that β4 dramatically promotes BK channel opening by shifting voltage sensor activation to more negative voltage ranges, but also slows activation to timescales that theoretically preclude BK ability to shape action potentials (APs). In addition, β4 membrane trafficking is regulated through an endoplasmic retention signal and palmitoylation. More recently, the challenge has been to understand the functional role of the iberiotoxin-resistant BK subtype utilizing computational modeling of neurons and neurophysiological approaches. Utilizing iberiotoxin-resistance as a footprint for these channels, they have been identified in dentate gyrus granule neurons and in purkinje neurons of the cerebellum. In these neurons, the role of these channels is largely consistent with slow-gated channels that reduce excitability either through an interspike conductance, such as in purkinje neurons, or by replacing fast-gating BK channels that otherwise facilitate high frequency AP firing, such as in dentate gyrus neurons. They are also observed in presynaptic mossy fiber terminals of the dentate gyrus and posterior pituitary terminals. More recent studies suggest that β4 subunits may also be expressed in some neurons lacking iberiotoxin-resistant BK channels, such as in CA3 hippocampus neurons. Ongoing research using novel, specific blockers and agonists of BK/β4, and β4 knockout mice, will continue to move the field forward in understanding the function of these

  1. Current understanding of iberiotoxin-resistant BK channels in the nervous system

    Directory of Open Access Journals (Sweden)

    Bin eWang

    2014-10-01

    Full Text Available While most large-conductance, calcium- and voltage-activated potassium channels (BK or Maxi-K type are blocked by the scorpion venom iberiotoxin, the so-called type II subtype has the property of toxin resistance. This property is uniquely mediated by channel assembly with one member of the BK accessory β subunit family, the neuron-enriched β4 subunit. This review will focus on current understanding of iberiotoxin-resistant, β4-containing BK channel properties and their function in the CNS. Studies have shown that β4 dramatically promotes BK channel opening by shifting voltage sensor activation to more negative voltage ranges, but also slows activation to timescales that theoretically preclude BK ability to shape action potentials (APs. In addition, β4 membrane trafficking is regulated through an endoplasmic retention signal and palmitoylation. More recently, the challenge has been to understand the functional role of the iberiotoxin-resistant BK subtype utilizing computational modeling of neurons and neurophysiological approaches. Utilizing iberiotoxin-resistance as a footprint for these channels, they have been identified in dentate gyrus granule neurons and in purkinje neurons of the cerebellum. In these neurons, the role of these channels is largely consistent with slow-gated channels that reduce excitability either through an interspike conductance, such as in purkinje neurons, or by replacing fast-gating BK channels that otherwise facilitate high frequency AP firing, such as in dentate gyrus neurons. They are also observed in presynaptic mossy fiber terminals of the dentate gyrus and posterior pituitary terminals. More recent studies suggest that β4 subunits may also be expressed in some neurons lacking iberiotoxin-resistant BK channels, such as in CA3 hippocampus neurons. Ongoing research using novel, specific blockers and agonists of BK/β4, and β4 knockout mice, will continue to move the field forward in understanding the

  2. Current understanding of the bi-directional relationship of major depression with inflammation

    Directory of Open Access Journals (Sweden)

    Messay Berhane

    2012-02-01

    Full Text Available Abstract Consistent evidence links major depression and its affective components to negative health outcomes. Although the pathways of these effects are likely complex and multifactorial, recent evidence suggests that innate inflammatory processes may play a role. An overview of current literature suggests that pathways between negative moods and inflammation are bi-directional. Indeed, negative moods activate peripheral physiologic mechanisms that result in an up regulation of systemic levels of inflammation. Conversely, peripheral inflammatory mediators signal the brain to affect behavioral, affective and cognitive changes that are consistent with symptoms of major depressive disorder. It is likely that these pathways are part of a complex feedback loop that involves the nervous, endocrine, and immune systems and plays a role in the modulation of peripheral inflammatory responses to central and peripheral stimuli, in central responses to peripheral immune activation and in the maintenance of homeostatic balance. Further research is warranted to fully understand the role of central processes in this feedback loop, which likely contributes to the pathophysiology of mental and physical health.

  3. Between understanding and appreciation. Current science communication in Denmark (Danish original version)

    OpenAIRE

    Kristian Hvidtfelt Nielsen.

    2005-01-01

    In this paper I use the concepts “understanding of science” and “appreciation of science” to analyze selected case studies of current science communication in Denmark. The Danish science communication system has many similarities with science communication in other countries: the increasing political and scientific interest in science communication, the co-existence of many different kinds of science communication, and the multiple uses of the concepts of understanding vs. appreciation of sci...

  4. Fuel-coolant interaction (FCI) phenomena in reactor safety. Current understanding and future research needs

    Energy Technology Data Exchange (ETDEWEB)

    Speis, T.P. [Maryland Univ., College Park, MD (United States); Basu, S.

    1998-01-01

    This paper gives an account of the current understanding of fuel-coolant interaction (FCI) phenomena in the context of reactor safety. With increased emphasis on accident management and with emerging in-vessel core melt retention strategies for advanced light water reactor (ALWR) designs, recent interest in FCI has broadened to include an evaluation of potential threats to the integrity of reactor vessel lower head and ex-vessel structural support, as well as the role of FCI in debris quenching and coolability. The current understanding of FCI with regard to these issues is discussed, and future research needs to address the issues from a risk perspective are identified. (author)

  5. Optimizing Quality of Care and Patient Safety in Malaysia: The Current Global Initiatives, Gaps and Suggested Solutions.

    Science.gov (United States)

    Jarrar, Mu'taman; Abdul Rahman, Hamzah; Don, Mohammad Sobri

    2015-10-20

    Demand for health care service has significantly increased, while the quality of healthcare and patient safety has become national and international priorities. This paper aims to identify the gaps and the current initiatives for optimizing the quality of care and patient safety in Malaysia. Review of the current literature. Highly cited articles were used as the basis to retrieve and review the current initiatives for optimizing the quality of care and patient safety. The country health plan of Ministry of Health (MOH) Malaysia and the MOH Malaysia Annual Reports were reviewed. The MOH has set four strategies for optimizing quality and sustaining quality of life. The 10th Malaysia Health Plan promotes the theme "1 Care for 1 Malaysia" in order to sustain the quality of care. Despite of these efforts, the total number of complaints received by the medico-legal section of the MOH Malaysia is increasing. The current global initiatives indicted that quality performance generally belong to three main categories: patient; staffing; and working environment related factors. There is no single intervention for optimizing quality of care to maintain patient safety. Multidimensional efforts and interventions are recommended in order to optimize the quality of care and patient safety in Malaysia.

  6. Risk factors for venous thrombosis - current understanding from an epidemiological point of view

    NARCIS (Netherlands)

    Lijfering, Willem M.; Rosendaal, Frits R.; Cannegieter, Suzanne C.

    2010-01-01

    P>Epidemiological research throughout the last 50 years has provided the long list of risk factors for venous thrombosis that are known today. Although this has advanced our current understanding about the aetiology of thrombosis, it does not give us all the answers: many people have several of thes

  7. Design and array signal suggestion of array type pulsed eddy current probe for health monitoring of metal tubes

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Young Kil [Dept. of Electrical Engineering, Kunsan National University, Kunsan (Korea, Republic of)

    2015-10-15

    An array type probe for monitoring metal tubes is proposed in this paper which utilizes peak value and peak time of a pulsed eddy current(PEC) signal. The probe consists of an array of encircling coils along a tube and the outside of coils is shielded by ferrite to prevent source magnetic fields from directly affecting sensor signals since it is the magnetic fields produced by eddy currents that reflect the condition of metal tubes. The positions of both exciter and sensor coils are consecutively moved automatically so that manual scanning is not necessary. At one position of send-receive coils, peak value and peak time are extracted from a sensor PEC signal and these data are accumulated for all positions to form an array type peak value signal and an array type peak time signal. Numerical simulation was performed using the backward difference method in time and the finite element method for spatial analysis. Simulation results showed that peak value increases and the peak appears earlier as the defect depth or length increases. The proposed array signals are shown to be excellent in reflecting the defect location as well as variations of defect depth and length within the array probe.

  8. Preparing for the introduction of hospital autonomy in Laos: an assessment of current situation and suggestions for policy-making.

    Science.gov (United States)

    Geng, Jinsong; Yu, Hao; Chen, Yingyao

    2016-04-01

    The National Assembly of Lao People's Democratic Republic (Laos) approved the Health Sector Reform Strategy in 2012, which called for an assessment as to whether Laos should introduce hospital autonomy, and if so, in which ways. The purpose of this study is to assess the status quo of hospital governance in Laos and propose policy suggestions for hospital autonomy in the country. We formulated an analytic framework for hospital autonomy based on previous work by other researchers, collected qualitative data through key informant interviews and focus group discussions, and also performed secondary data analysis. Public hospitals in Laos enjoyed some informal autonomy with little accountability and Laos is facing key challenges of hospital governance. As a result, introducing hospital autonomy in Laos could bring risks, benefits and debates. Before Laos decides on granting autonomy to its public hospitals, we strongly suggest that the government do pilot in selected public hospitals with well-regulated governance framework first and conduct rigorous evaluations to examine whether the granted autonomy leads to the intended social goals of equity, quality, efficiency and sustainability. We recommend residual claimants should be monitored by the government and by the society with open and transparent approach, and active measures should be taken to improve performance and ensure social functions. The study findings may also provide some suggestions for low- and middle-income countries, which are contemplating the introduction of hospital autonomy in the public sector. Copyright © 2015 John Wiley & Sons, Ltd.

  9. Effects of soil rewetting and thawing on soil gas fluxes: a review of current literature and suggestions for future research

    Directory of Open Access Journals (Sweden)

    D.-G. Kim

    2011-10-01

    Full Text Available The rewetting of dry soils and the thawing of frozen soils are short-term, transitional phenomena in terms of hydrology and the thermodynamics of soil systems. The impact of these short-term phenomena on larger scale ecosystem fluxes has only recently been fully appreciated, and a growing number of studies show that these events affect various biogeochemical processes including fluxes of soil gases such as carbon dioxide (CO2, methane (CH4, nitrous oxide (N2O, ammonia (NH3 and nitric oxide (NO. Global climate models predict that future climatic change is likely to alter the frequency and intensity of drying-rewetting events and thawing of frozen soils, highlighting the importance of understanding how rewetting and thawing will influence soil gas fluxes. Here we summarize findings in a new database based on 338 studies conducted from 1956 to 2010, and highlight open research questions. The database revealed conflicting results following rewetting and thawing in various terrestrial ecosystems, ranging from large increases in gas fluxes to non-significant changes. An analysis of published field studies (n = 142 showed that after rewetting or thawing, CO2, CH4, N2O, NO and NH3 fluxes increase from pre-event fluxes following a power function, with no significant differenced among gases. We discuss possible mechanisms and controls that regulate flux responses, and note that a high temporal resolution of flux measurements is critical to capture rapid changes in gas fluxes after these soil perturbations. Finally, we propose that future studies should investigate the interactions between biological (i.e. microbial community and gas production and physical (i.e. flux, diffusion, dissolution changes in soil gas fluxes, and explore synergistic experimental and modelling approaches.

  10. Photocatalytic effects of titanium dioxide nanoparticles on aquatic organisms-Current knowledge and suggestions for future research.

    Science.gov (United States)

    Haynes, Vena N; Ward, J Evan; Russell, Brandon J; Agrios, Alexander G

    2017-04-01

    Nanoparticles are entering natural systems through product usage, industrial waste and post-consumer material degradation. As the production of nanoparticles is expected to increase in the next decade, so too are predicted environmental loads. Engineered metal-oxide nanomaterials, such as titanium dioxide, are known for their photocatalytic capabilities. When these nanoparticles are exposed to ultraviolet radiation in the environment, however, they can produce radicals that are harmful to aquatic organisms. There have been a number of studies that have reported the toxicity of titanium dioxide nanoparticles in the absence of light. An increasing number of studies are assessing the interactive effects of nanoparticles and ultraviolet light. However, most of these studies neglect environmentally-relevant experimental conditions. For example, researchers are using nanoparticle concentrations and light intensities that are too high for natural systems, and are ignoring water constituents that can alter the light field. The purpose of this review is to summarize the current knowledge of the photocatalytic effects of TiO2 nanoparticles on aquatic organisms, discuss the limitations of these studies, and outline environmentally-relevant factors that need to be considered in future experiments. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Creating healthy work in small enterprises - from understanding to action:Summary of current knowledge

    OpenAIRE

    Stephen, legg; Ian S., laird; Olsen, Kirsten Bendix; Hasle, Peter

    2014-01-01

    Although much is known about small and medium enterprises (SMEs), our current knowledge and understanding of occupational health and safety (OHS) and the work environment in SMEs is limited. Far less is known about how SMEs put our knowledge of OSH into action. In short, how do we create healthy work and healthy lives as well as ‘healthy business' in SMEs? The present paper, which also acts as an editorial for this special issue, addresses these questions by providing a summary of current kno...

  12. Manifesto for the current understanding and management of traumatic brain injury-induced hypopituitarism

    DEFF Research Database (Denmark)

    Tanriverdi, F; Agha, A; Aimaretti, G

    2011-01-01

    Traumatic brain injury (TBI)-induced hypopituitarism remains a relevant medical problem, because it may affect a significant proportion of the population. In the last decade important studies have been published investigating pituitary dysfunction after TBI. Recently, a group of experts gathered...... and revisited the topic of TBI-induced hypopituitarism. During the 2-day meeting, the main issues of this topic were presented and discussed, and current understanding and management of TBI-induced hypopituitarism are summarized here....

  13. Manifesto for the current understanding and management of traumatic brain injury-induced hypopituitarism.

    LENUS (Irish Health Repository)

    Tanriverdi, F

    2011-01-01

    Traumatic brain injury (TBI)-induced hypopituitarism remains a relevant medical problem, because it may affect a significant proportion of the population. In the last decade important studies have been published investigating pituitary dysfunction after TBI. Recently, a group of experts gathered and revisited the topic of TBI-induced hypopituitarism. During the 2-day meeting, the main issues of this topic were presented and discussed, and current understanding and management of TBI-induced hypopituitarism are summarized here.

  14. Current understanding of the formation and adaptation of metabolic systems based on network theory.

    Science.gov (United States)

    Takemoto, Kazuhiro

    2012-07-12

    Formation and adaptation of metabolic networks has been a long-standing question in biology. With recent developments in biotechnology and bioinformatics, the understanding of metabolism is progressively becoming clearer from a network perspective. This review introduces the comprehensive metabolic world that has been revealed by a wide range of data analyses and theoretical studies; in particular, it illustrates the role of evolutionary events, such as gene duplication and horizontal gene transfer, and environmental factors, such as nutrient availability and growth conditions, in evolution of the metabolic network. Furthermore, the mathematical models for the formation and adaptation of metabolic networks have also been described, according to the current understanding from a perspective of metabolic networks. These recent findings are helpful in not only understanding the formation of metabolic networks and their adaptation, but also metabolic engineering.

  15. A historical study to understand students’ current difficulties about RMS values

    Science.gov (United States)

    Khantine-Langlois, Françoise; Munier, Valérie

    2016-07-01

    Several studies show that students experience more and more difficulties managing the measurements of electrical values in alternating current and that they have trouble making links between theory and practice. They find it difficult to give meaning to root mean square (RMS; or effective) values, which are not understood as average values and are confused with instantaneous values. This shows that students do not clearly differentiate variable and direct currents. In this paper we try, with a historical study and a study of teaching the concept of RMS values, to understand students’ difficulties with this concept. In the first part we present an epistemological analysis of the concept of RMS values, showing that it is multifaceted and can be approached from different points of view. In the second part we analyse the evolution of French secondary school curricula and textbooks from the explicit introduction of variable currents to today, questioning the links between the evolution of the curricula and the evolution of the place of science and technology in our societies. We point out that the evolution of the curricula is linked to the social context and to the connections between science, technology and society, and also to the relationship with mathematics curricula. We show that alternating current is introduced earlier in the curriculum but has gradually lost all phenomenological description. This study allows us to better understand students’ difficulties and to discuss some implications for teaching.

  16. History of the current understanding and management of tethered spinal cord.

    Science.gov (United States)

    Safavi-Abbasi, Sam; Mapstone, Timothy B; Archer, Jacob B; Wilson, Christopher; Theodore, Nicholas; Spetzler, Robert F; Preul, Mark C

    2016-07-01

    An understanding of the underlying pathophysiology of tethered cord syndrome (TCS) and modern management strategies have only developed within the past few decades. Current understanding of this entity first began with the understanding and management of spina bifida; this later led to the gradual recognition of spina bifida occulta and the symptoms associated with tethering of the filum terminale. In the 17th century, Dutch anatomists provided the first descriptions and initiated surgical management efforts for spina bifida. In the 19th century, the term "spina bifida occulta" was coined and various presentations of spinal dysraphism were appreciated. The association of urinary, cutaneous, and skeletal abnormalities with spinal dysraphism was recognized in the 20th century. Early in the 20th century, some physicians began to suspect that traction on the conus medullaris caused myelodysplasia-related symptoms and that prophylactic surgical management could prevent the occurrence of clinical manifestations. It was not, however, until later in the 20th century that the term "tethered spinal cord" and the modern management of TCS were introduced. This gradual advancement in understanding at a time before the development of modern imaging modalities illustrates how, over the centuries, anatomists, pathologists, neurologists, and surgeons used clinical examination, a high level of suspicion, and interest in the subtle and overt clinical appearances of spinal dysraphism and TCS to advance understanding of pathophysiology, clinical appearance, and treatment of this entity. With the availability of modern imaging, spinal dysraphism can now be diagnosed and treated as early as the intrauterine stage.

  17. Current understanding of iberiotoxin-resistant BK channels in the nervous system

    OpenAIRE

    Bin eWang; Jaffe, David B.; Robert eBrenner

    2014-01-01

    While most large-conductance, calcium- and voltage-activated potassium channels (BK or Maxi-K type) are blocked by the scorpion venom iberiotoxin, the so-called type II subtype has the property of toxin resistance. This property is uniquely mediated by channel assembly with one member of the BK accessory β subunit family, the neuron-enriched β4 subunit. This review will focus on current understanding of iberiotoxin-resistant, β4-containing BK channel properties and their function in the CNS. ...

  18. CANCER IMMUNOLOGY AND IMMUNOTHERAPY – UNDERSTANDING AND ADAPTATION THE CURRENT EVIDENCE TO OPTIMIZE PATIENT THERAPY OUTCOMES.

    Directory of Open Access Journals (Sweden)

    Orlin Savov

    2015-11-01

    Full Text Available The aim of this publication includes the try to act as intermediary to the readers, which should be able to understand: - The description of the cancer immunotherapy mechanisms in the context of current therapy decisions for the treatment of cancer - The including criteria for those patients with cancer who could be appropriate candidates for immunotherapy - And to optimize patient outcomes by using best practices to manage the adverse events associated with immunotherapy treatment More than 15 promising immunotherapy approaches being tested in clinical trials with appropriate patients and colleagues for enrollment and peer-to-peer education purposes, respectively.

  19. Microstructural understanding and critical current optimization of advanced high field superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Bonney, L.A.; Willis, T.C.; Larbalestier, D.C.

    1993-01-01

    It is of great importance to improve critical current density, J[sub c] in A15 superconductors for high field magnet applications. Most current work to improve J[sub c] in A15 wires concentrates on increasing the overall J[sub c] by increasing the fraction of superconducting phase in the wire, by improving the uniformity of the superconductor cross section along the length of the wire and by adjusting the strainstate of the A15 layer. The goal of the A15 work in this group was to investigate the intrinsic J[sub c] of the A15 layer itself. To do this, a better understanding of factors controlling the intrinsic J[sub c]of the Nb[sub 3]Sn was pursued.

  20. Geomorphic and vegetation processes of the Willamette River floodplain, Oregon: current understanding and unanswered science questions

    Science.gov (United States)

    Wallick, J. Rose; Jones, Krista L.; O'Connor, Jim E.; Keith, Mackenzie K.; Hulse, David; Gregory, Stanley V.

    2013-01-01

    This report summarizes the current understanding of floodplain processes and landforms for the Willamette River and its major tributaries. The area of focus encompasses the main stem Willamette River above Newberg and the portions of the Coast Fork Willamette, Middle Fork Willamette, McKenzie, and North, South and main stem Santiam Rivers downstream of U.S. Army Corps of Engineers dams. These reaches constitute a large portion of the alluvial, salmon-bearing rivers in the Willamette Basin. The geomorphic, or historical, floodplain of these rivers has two zones - the active channel where coarse sediment is mobilized and transported during annual flooding and overbank areas where fine sediment is deposited during higher magnitude floods. Historically, characteristics of the rivers and geomorphic floodplain (including longitudinal patterns in channel complexity and the abundance of side channels, islands and gravel bars) were controlled by the interactions between floods and the transport of coarse sediment and large wood. Local channel responses to these interactions were then shaped by geologic features like bedrock outcrops and variations in channel slope. Over the last 150 years, floods and the transport of coarse sediment and large wood have been substantially reduced in the basin. With dam regulation, nearly all peak flows are now confined to the main channels. Large floods (greater than 10-year recurrence interval prior to basinwide flow regulation) have been largely eliminated. Also, the magnitude and frequency of small floods (events that formerly recurred every 2–10 years) have decreased substantially. The large dams trap an estimated 50–60 percent of bed-material sediment—the building block of active channel habitats—that historically entered the Willamette River. They also trap more than 80 percent of the estimated bed material in the lower South Santiam River and Middle and Coast Forks of the Willamette River. Downstream, revetments further

  1. Relationship between Added Sugars Consumption and Chronic Disease Risk Factors: Current Understanding

    Directory of Open Access Journals (Sweden)

    James M. Rippe

    2016-11-01

    Full Text Available Added sugars are a controversial and hotly debated topic. Consumption of added sugars has been implicated in increased risk of a variety of chronic diseases including obesity, cardiovascular disease, diabetes and non-alcoholic fatty liver disease (NAFLD as well as cognitive decline and even some cancers. Support for these putative associations has been challenged, however, on a variety of fronts. The purpose of the current review is to summarize high impact evidence including systematic reviews, meta-analyses, and randomized controlled trials (RCTs, in an attempt to provide an overview of current evidence related to added sugars and health considerations. This paper is an extension of a symposium held at the Experimental Biology 2015 conference entitled “Sweeteners and Health: Current Understandings, Controversies, Recent Research Findings and Directions for Future Research”. We conclude based on high quality evidence from randomized controlled trials (RCT, systematic reviews and meta-analyses of cohort studies that singling out added sugars as unique culprits for metabolically based diseases such as obesity, diabetes and cardiovascular disease appears inconsistent with modern, high quality evidence and is very unlikely to yield health benefits. While it is prudent to consume added sugars in moderation, the reduction of these components of the diet without other reductions of caloric sources seems unlikely to achieve any meaningful benefit.

  2. Relationship between Added Sugars Consumption and Chronic Disease Risk Factors: Current Understanding

    Science.gov (United States)

    Rippe, James M.; Angelopoulos, Theodore J.

    2016-01-01

    Added sugars are a controversial and hotly debated topic. Consumption of added sugars has been implicated in increased risk of a variety of chronic diseases including obesity, cardiovascular disease, diabetes and non-alcoholic fatty liver disease (NAFLD) as well as cognitive decline and even some cancers. Support for these putative associations has been challenged, however, on a variety of fronts. The purpose of the current review is to summarize high impact evidence including systematic reviews, meta-analyses, and randomized controlled trials (RCTs), in an attempt to provide an overview of current evidence related to added sugars and health considerations. This paper is an extension of a symposium held at the Experimental Biology 2015 conference entitled “Sweeteners and Health: Current Understandings, Controversies, Recent Research Findings and Directions for Future Research”. We conclude based on high quality evidence from randomized controlled trials (RCT), systematic reviews and meta-analyses of cohort studies that singling out added sugars as unique culprits for metabolically based diseases such as obesity, diabetes and cardiovascular disease appears inconsistent with modern, high quality evidence and is very unlikely to yield health benefits. While it is prudent to consume added sugars in moderation, the reduction of these components of the diet without other reductions of caloric sources seems unlikely to achieve any meaningful benefit. PMID:27827899

  3. Cell and molecular biology of intervertebral disc degeneration: current understanding and implications for potential therapeutic strategies.

    Science.gov (United States)

    Wang, S Z; Rui, Y F; Lu, J; Wang, C

    2014-10-01

    Intervertebral disc degeneration (IDD) is a chronic, complex process associated with low back pain; mechanisms of its occurrence have not yet been fully elucidated. Its process is not only accompanied by morphological changes, but also by systematic changes in its histological and biochemical properties. Many cellular and molecular mechanisms have been reported to be related with IDD and to reverse degenerative trends, abnormal conditions of the living cells and altered cell phenotypes would need to be restored. Promising biological therapeutic strategies still rely on injection of active substances, gene therapy and cell transplantation. With advanced study of tissue engineering protocols based on cell therapy, combined use of seeding cells, bio-active substances and bio-compatible materials, are promising for IDD regeneration. Recently reported progenitor cells within discs themselves also hold prospects for future IDD studies. This article describes the background of IDD, current understanding and implications of potential therapeutic strategies.

  4. The current understanding of trauma-induced coagulopathy (TIC): a focused review on pathophysiology.

    Science.gov (United States)

    Giordano, Stefano; Spiezia, Luca; Campello, Elena; Simioni, Paolo

    2017-05-05

    The emergency management of acute severe bleeding in trauma patients has changed significantly in recent years. In particular, greater attention is now being devoted to a prompt assessment of coagulation alterations, which allows for immediate haemostatic resuscitation procedures when necessary. The importance of an early trauma-induced coagulopathy (TIC) diagnosis has led physicians to increase the efforts to better understand the pathophysiological alterations observed in the haemostatic system after traumatic injuries. As yet, the knowledge of TIC is not exhaustive, and further studies are needed. The aim of this review is to gather all the currently available data and information in an attempt to gain a better understanding of TIC. A comprehensive literature search was performed using MEDLINE database. The bibliographies of relevant articles were screened for additional publications. In major traumas, coagulopathic bleeding stems from a complex interplay among haemostatic and inflammatory systems, and is characterized by a multifactorial dysfunction. In the abundance of biochemical and pathophysiological changes occurring after trauma, it is possible to discern endogenously induced primary predisposing conditions and exogenously induced secondary predisposing conditions. TIC remains one of the most diagnostically and therapeutically challenging condition.

  5. Emergency nurses' current practices and understanding of family presence during CPR.

    LENUS (Irish Health Repository)

    Madden, Eilis

    2012-02-03

    PURPOSE: To examine emergency nurses\\' current practices and understanding of family presence during CPR in the emergency department, Cork University Hospital, Republic of Ireland. METHOD: A quantitative descriptive design was used in the study. A questionnaire developed by ENA was distributed to emergency nurses working in a level I trauma emergency department at Cork University Hospital. The total sample number was 90, including all emergency nurses with at least 6 months\\' emergency nursing experience. RESULTS: Emergency nurses often took families to the bedside during resuscitation efforts (58.9%) or would do so if the opportunity arose (17.8%). A high percentage (74.4%) of respondents would prefer a written policy allowing the option of family presence during CPR. The most significant barrier to family witnessed resuscitation (FWR) was conflicts occurring within the emergency team. The most significant facilitator to FWR was a greater understanding of health care professionals on the benefits of FWR to patients and families, indicating the need for educational development. CONCLUSION: The findings of the study and previously published studies indicate the need for development of written polices and guidelines on the practice to meet the needs of patients, families, and staff by providing consistent, safe, and caring practices for all involved in the resuscitation process. Recommendations of the study include the development of a written policy and an educational programme on the safe implementation and practices of FWR.

  6. Current gaps in understanding and predicting space weather: An operations perspective

    Science.gov (United States)

    Murtagh, W. J.

    2016-12-01

    The NOAA Space Weather Prediction Center (SWPC), one of the nine National Weather Service (NWS) National Centers for Environmental Prediction, is the Nation's official source for space weather alerts and warnings. Space weather effects the technology that forms the backbone of global economic vitality and national security, including satellite and airline operations, communications networks, and the electric power grid. Many of SWPC's over 48,000 subscribers rely on space weather forecasts for critical decision making. But extraordinary gaps still exist in our ability to meet customer needs for accurate and timely space weather forecasts and warnings. The 2015 National Space Weather Strategy recognizes that it is imperative that we improve the fundamental understanding of space weather and increase the accuracy, reliability, and timeliness of space-weather observations and forecasts in support of the growing demands. In this talk we provide a broad perspective of the key challenges that currently limit the forecaster's ability to better understand and predict space weather. We also examine the impact of these limitations on the end-user community.

  7. Transcription Factors and Plants Response to Drought Stress: Current Understanding and Future Directions

    Science.gov (United States)

    Joshi, Rohit; Wani, Shabir H.; Singh, Balwant; Bohra, Abhishek; Dar, Zahoor A.; Lone, Ajaz A.; Pareek, Ashwani; Singla-Pareek, Sneh L.

    2016-01-01

    Increasing vulnerability of plants to a variety of stresses such as drought, salt and extreme temperatures poses a global threat to sustained growth and productivity of major crops. Of these stresses, drought represents a considerable threat to plant growth and development. In view of this, developing staple food cultivars with improved drought tolerance emerges as the most sustainable solution toward improving crop productivity in a scenario of climate change. In parallel, unraveling the genetic architecture and the targeted identification of molecular networks using modern “OMICS” analyses, that can underpin drought tolerance mechanisms, is urgently required. Importantly, integrated studies intending to elucidate complex mechanisms can bridge the gap existing in our current knowledge about drought stress tolerance in plants. It is now well established that drought tolerance is regulated by several genes, including transcription factors (TFs) that enable plants to withstand unfavorable conditions, and these remain potential genomic candidates for their wide application in crop breeding. These TFs represent the key molecular switches orchestrating the regulation of plant developmental processes in response to a variety of stresses. The current review aims to offer a deeper understanding of TFs engaged in regulating plant’s response under drought stress and to devise potential strategies to improve plant tolerance against drought. PMID:27471513

  8. Transcription factors and plant response to drought stress: Current understanding and future directions

    Directory of Open Access Journals (Sweden)

    Rohit Joshi

    2016-07-01

    Full Text Available Increasing vulnerability of plants to a variety of stresses such as drought, salt and extreme temperatures poses a global threat to sustained growth and productivity of major crops. Of these stresses, drought represents a considerable threat to plant growth and development. In view of this, developing staple food cultivars with improved drought tolerance emerges as the most sustainable solution towards improving crop productivity in a scenario of climate change. In parallel, unraveling the genetic architecture and the targeted identification of molecular networks using modern OMICS analyses, that can underpin drought tolerance mechanisms, is urgently required. Importantly, integrated studies intending to elucidate complex mechanisms can bridge the gap existing in our current knowledge about drought stress tolerance in plants. It is now well established that drought tolerance is regulated by several genes, including transcription factors (TFs that enable plants to withstand unfavorable conditions, and these remain potential genomic candidates for their wide application in crop breeding. These TFs represent the key molecular switches orchestrating the regulation of plant developmental processes in response to a variety of stresses. The current review aims to offer a deeper understanding of TFs engaged in regulating plant’s response under drought stress and to devise potential strategies to improve plant tolerance against drought.

  9. Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis.

    Science.gov (United States)

    Martin, Roland; Sospedra, Mireia; Rosito, Maria; Engelhardt, Britta

    2016-09-01

    Multiple sclerosis (MS) is the most common inflammatory disorder of the central nervous system (CNS) in young adults. When MS is not treated, it leads to irreversible and severe disability. The etiology of MS and its pathogenesis are not fully understood. The recent discovery that MS-associated genetic variants code for molecules related to the function of specific immune cell subsets is consistent with the concept of MS as a prototypic, T-cell-mediated autoimmune disease targeting the CNS. While the therapeutic efficacy of the currently available immunomodulatory therapies further strengthen this concept, differences observed in responses to MS treatment as well as additional clinical and imaging observations have also shown that the autoimmune pathogenesis underlying MS is much more complex than previously thought. There is therefore an unmet need for continued detailed phenotypic and functional analysis of disease-relevant adaptive immune cells and tissues directly derived from MS patients to unravel the immune etiology of MS in its entire complexity. In this review, we will discuss the currently available MS treatment options and approved drugs, including how they have contributed to the understanding of the immune pathology of this autoimmune disease.

  10. Current progress on understanding the impact of mercury on human health.

    Science.gov (United States)

    Ha, Eunhee; Basu, Niladri; Bose-O'Reilly, Stephan; Dórea, José G; McSorley, Emeir; Sakamoto, Mineshi; Chan, Hing Man

    2017-01-01

    Mercury pollution and its impacts on human health is of global concern. The authors of this paper were members of the Plenary Panel on Human Health in the 12th International Conference on Mercury as a Global Pollutant held in Korea in June 2015. The Panel was asked by the conference organizers to address two questions: what is the current understanding of the impacts of mercury exposure on human health and what information is needed to evaluate the effectiveness of the Minamata Convention in lowering exposure and preventing adverse effects. The authors conducted a critical review of the literature published since January 2012 and discussed the current state-of-knowledge in the following areas: environmental exposure and/or risk assessment; kinetics and biomonitoring; effects on children development; effects on adult general populations; effects on artisanal and small-scale gold miners (ASGM); effects on dental workers; risk of ethylmercury in thimerosal-containing vaccines; interactions with nutrients; genetic determinants and; risk communication and management. Knowledge gaps in each area were identified and recommendations for future research were made. The Panel concluded that more knowledge synthesis efforts are needed to translate the research results into management tools for health professionals and policy makers. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Chemotherapy-induced peripheral neuropathy: an update on the current understanding [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    James Addington

    2016-06-01

    Full Text Available Chemotherapy-induced peripheral neuropathy is a common side effect of selected chemotherapeutic agents. Previous work has suggested that patients often under report the symptoms of chemotherapy-induced peripheral neuropathy and physicians fail to recognize the presence of such symptoms in a timely fashion. The precise pathophysiology that underlies chemotherapy-induced peripheral neuropathy, in both the acute and the chronic phase, remains complex and appears to be medication specific. Recent work has begun to demonstrate and further clarify potential pathophysiological processes that predispose and, ultimately, lead to the development of chemotherapy-induced peripheral neuropathy. There is increasing evidence that the pathway to neuropathy varies with each agent. With a clearer understanding of how these agents affect the peripheral nervous system, more targeted treatments can be developed in order to optimize treatment and prevent long-term side effects.

  12. Field—Scale Contaminant Transport Through Soils: Current Understanding and Open Questions

    Institute of Scientific and Technical Information of China (English)

    ZHANGJIABAO; K.ROTH

    1999-01-01

    Agro-chemical transport processes at different scales are discussed and relevant opening question are identified by literature review to make some suggestions concerning the improvement of research methods for filed scale solute transport by aid of evaluation of existing models,and examining transport behaviors of solute in vadose zones on different scales.The results indicate that present research progess and understanding on field scale solute transport have not yet been enough to guarantee the use of our models for the management of field soulte movement.Much more research work needs to be done,particularly,in aspects of high resolution of spatial structures relevant to the hydraulic and transport properties,explicit numerical simulation of actual structure on field scale and field measurement corroborated with model development.

  13. Chemotherapy-induced peripheral neuropathy: an update on the current understanding.

    Science.gov (United States)

    Addington, James; Freimer, Miriam

    2016-01-01

    Chemotherapy-induced peripheral neuropathy is a common side effect of selected chemotherapeutic agents. Previous work has suggested that patients often under report the symptoms of chemotherapy-induced peripheral neuropathy and physicians fail to recognize the presence of such symptoms in a timely fashion. The precise pathophysiology that underlies chemotherapy-induced peripheral neuropathy, in both the acute and the chronic phase, remains complex and appears to be medication specific. Recent work has begun to demonstrate and further clarify potential pathophysiological processes that predispose and, ultimately, lead to the development of chemotherapy-induced peripheral neuropathy. There is increasing evidence that the pathway to neuropathy varies with each agent. With a clearer understanding of how these agents affect the peripheral nervous system, more targeted treatments can be developed in order to optimize treatment and prevent long-term side effects.

  14. Current ecological understanding of fungal-like pathogens of fish: what lies beneath?

    Directory of Open Access Journals (Sweden)

    Rodolphe Elie Gozlan

    2014-02-01

    Full Text Available Despite increasingly sophisticated microbiological techniques, and long after the first discovery of microbes, basic knowledge is still lacking to fully appreciate the ecological importance of microbial parasites in fish. This is likely due to the nature of their habitats as many species of fish suffer from living beneath turbid water away from easy recording. However, fishes represent key ecosystem services for millions of people around the world and the absence of a functional ecological understanding of viruses, prokaryotes, and small eukaryotes in the maintenance of fish populations and of their diversity represents an inherent barrier to aquatic conservation and food security. Among recent emerging infectious diseases responsible for severe population declines in plant and animal taxa, fungal and fungal-like microbes have emerged as significant contributors. Here, we review the current knowledge gaps of fungal and fungal-like parasites and pathogens in fish and put them into an ecological perspective with direct implications for the monitoring of fungal fish pathogens in the wild, their phylogeography as well as their associated ecological impact on fish populations. With increasing fish movement around the world for farming, releases into the wild for sport fishing and human-driven habitat changes, it is expected, along with improved environmental monitoring of fungal and fungal-like infections, that the full extent of the impact of these pathogens on wild fish populations will soon emerge as a major threat to freshwater biodiversity.

  15. Understanding the current state of infection preventionists through competency, role, and activity self-assessment.

    Science.gov (United States)

    Kalp, Ericka L; Marx, James F; Davis, James

    2017-06-01

    The Association for Professionals in Infection Control and Epidemiology (APIC) MegaSurvey, administered in 2015, was completed by approximately 4,079 APIC members. The survey sought to gain a better understanding the current state of 4 components of infection prevention practice: demographic characteristics, compensation, organizational structure, and practice and competency. The data for this analysis come from the APIC MegaSurvey Practice and Competency domain. Descriptive statistics and χ(2) analyses were conducted to examine differences in infection preventionist (IP) competency, roles, and activity self-assessments. The majority of IPs self-assessed their competency as Proficient compared with Novice or Expert for each of the 8 IP core competency activities. Forty percent of IPs self-rated their competency as Expert in the Preventing/Controlling the Transmission of Infectious Agents/HAIs component. IPs reported Novice competency in Employee/Occupational Health (29%); Cleaning, Sterilization, Disinfection, and Asepsis (23%); and Education and Research categories (22%). Differences in self-rated competency among IPs by discipline type (public health, nurse, and laboratory) were identified. Differences in self-rated competency were identified for each of the 8 IP core competency activities. IPs report using various resource types to gain competency. Future research is needed to identify opportunities to increase competency levels in the weakest-rated competency activities. Copyright © 2017 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  16. Review: Animal model and the current understanding of molecule dynamics of adipogenesis.

    Science.gov (United States)

    Campos, C F; Duarte, M S; Guimarães, S E F; Verardo, L L; Wei, S; Du, M; Jiang, Z; Bergen, W G; Hausman, G J; Fernyhough-Culver, M; Albrecht, E; Dodson, M V

    2016-06-01

    Among several potential animal models that can be used for adipogenic studies, Wagyu cattle is the one that presents unique molecular mechanisms underlying the deposit of substantial amounts of intramuscular fat. As such, this review is focused on current knowledge of such mechanisms related to adipose tissue deposition using Wagyu cattle as model. So abundant is the lipid accumulation in the skeletal muscles of these animals that in many cases, the muscle cross-sectional area appears more white (adipose tissue) than red (muscle fibers). This enhanced marbling accumulation is morphologically similar to that seen in numerous skeletal muscle dysfunctions, disease states and myopathies; this might indicate cross-similar mechanisms between such dysfunctions and fat deposition in Wagyu breed. Animal models can be used not only for a better understanding of fat deposition in livestock, but also as models to an increased comprehension on molecular mechanisms behind human conditions. This revision underlies some of the complex molecular processes of fat deposition in animals.

  17. Effect of Current Electricity Simulation Supported Learning on the Conceptual Understanding of Elementary and Secondary Teachers

    Science.gov (United States)

    Kumar, David Devraj; Thomas, P. V.; Morris, John D.; Tobias, Karen M.; Baker, Mary; Jermanovich, Trudy

    2011-04-01

    This study examined the impact of computer simulation and supported science learning on a teacher's understanding and conceptual knowledge of current electricity. Pre/Post tests were used to measure the teachers' concept attainment. Overall, there was a significant and large knowledge difference effect from Pre to Post test. Two interesting interactions were observed during the data analysis. The first was the difference between Elementary and Secondary teachers. Both groups had significant gains, with large effect sizes, but the Elementary teachers (Pre-Mean = 3.70, Post-Mean = 7.51) started lower and ended higher exhibiting a significantly larger gain than the Secondary teachers (Pre-Mean = 4.96, Post-Mean = 6.71). The second interaction was the impact of gender. Both groups showed significant gains, with large effect sizes, but females (Pre-Mean = 3.90, Post-Mean = 7.21) gained significantly more than males (Pre-Mean = 5.13, Post-Mean = 7.01). These results confirm that computer simulation supported science learning can have a positive effect on concept attainment in teachers.

  18. Understanding the Dynamical Evolution of the Earth Radiation Belt and Ring Current Coupled System

    Science.gov (United States)

    Shprits, Yuri; Usanova, Maria; Kellerman, Adam; Drozdov, Alexander

    2016-07-01

    Modeling and understanding the ring current and radiation belt-coupled system has been a grand challenge since the beginning of the space age. In this study we show long-term simulations with a 3D Versatile Electron Radiation Belt (VERB) code of modeling the radiation belts with boundary conditions derived from observations around geosynchronous orbit. Simulations can reproduce long term variations of the electron radiation belt fluxes and show the importance of local acceleration, radial diffusion, loss to the atmosphere and loss to the magnetopause. We also present 4D VERB simulations that include convective transport, radial diffusion, pitch angle scattering and local acceleration. VERB simulations show that the lower energy inward transport is dominated by the convection and higher energy transport is dominated by the diffusive radial transport. We also show that at energies of 100s of keV, a number of processes work simultaneously, including convective transport, radial diffusion, local acceleration, loss to the loss cone and loss to the magnetopause. The results of the simulation of the March 2013 storm are compared with Van Allen Probes observations.

  19. Current Understanding and Remaining Challenges in Modeling Long-Term Degradation of Borosilicate Nuclear Waste Glasses

    Energy Technology Data Exchange (ETDEWEB)

    Vienna, John D. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Ryan, Joseph V. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Gin, Stephane [CEA Marcoule, DTCD SECM, Bagnols-sur-Ceze (France); Inagaki, Yaohiro [Dept. of Applied Quantum Physics and Nuclear Engineering, Kyushu University, Fukuoda (Japan)

    2013-12-01

    Chemical durability is not a single material property that can be uniquely measured. Instead it is the response to a host of coupled material and environmental processes whose rates are estimated by a combination of theory, experiment, and modeling. High-level nuclear waste (HLW) glass is perhaps the most studied of any material yet there remain significant technical gaps regarding their chemical durability. The phenomena affecting the long-term performance of HLW glasses in their disposal environment include surface reactions, transport properties to and from the reacting glass surface, and ion exchange between the solid glass and the surrounding solution and alteration products. The rates of these processes are strongly influenced and are coupled through the solution chemistry, which is in turn influenced by the reacting glass and also by reaction with the near-field materials and precipitation of alteration products. Therefore, those processes must be understood sufficiently well to estimate or bound the performance of HLW glass in its disposal environment over geologic time-scales. This article summarizes the current state of understanding of surface reactions, transport properties, and ion exchange along with the near-field materials and alteration products influences on solution chemistry and glass reaction rates. Also summarized are the remaining technical gaps along with recommended approaches to fill those technical gaps.

  20. Danger Signals and Graft-versus-host Disease: Current Understanding and Future Perspectives

    Science.gov (United States)

    Toubai, Tomomi; Mathewson, Nathan D.; Magenau, John; Reddy, Pavan

    2016-01-01

    Graft-versus-host response after allogeneic hematopoietic stem cell transplantation (allo-HCT) represents one of the most intense inflammatory responses observed in humans. Host conditioning facilitates engraftment of donor cells, but the tissue injury caused from it primes the critical first steps in the development of acute graft-versus-host disease (GVHD). Tissue injuries release pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6) through widespread stimulation of pattern recognition receptors (PRRs) by the release of danger stimuli, such as damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). DAMPs and PAMPs function as potent stimulators for host and donor-derived antigen presenting cells (APCs) that in turn activate and amplify the responses of alloreactive donor T cells. Emerging data also point towards a role for suppression of DAMP induced inflammation by the APCs and donor T cells in mitigating GVHD severity. In this review, we summarize the current understanding on the role of danger stimuli, such as the DAMPs and PAMPs, in GVHD. PMID:27965667

  1. Current ecological understanding of fungal-like pathogens of fish: what lies beneath?

    Science.gov (United States)

    Gozlan, Rodolphe E; Marshall, Wyth L; Lilje, Osu; Jessop, Casey N; Gleason, Frank H; Andreou, Demetra

    2014-01-01

    Despite increasingly sophisticated microbiological techniques, and long after the first discovery of microbes, basic knowledge is still lacking to fully appreciate the ecological importance of microbial parasites in fish. This is likely due to the nature of their habitats as many species of fish suffer from living beneath turbid water away from easy recording. However, fishes represent key ecosystem services for millions of people around the world and the absence of a functional ecological understanding of viruses, prokaryotes, and small eukaryotes in the maintenance of fish populations and of their diversity represents an inherent barrier to aquatic conservation and food security. Among recent emerging infectious diseases responsible for severe population declines in plant and animal taxa, fungal and fungal-like microbes have emerged as significant contributors. Here, we review the current knowledge gaps of fungal and fungal-like parasites and pathogens in fish and put them into an ecological perspective with direct implications for the monitoring of fungal fish pathogens in the wild, their phylogeography as well as their associated ecological impact on fish populations. With increasing fish movement around the world for farming, releases into the wild for sport fishing and human-driven habitat changes, it is expected, along with improved environmental monitoring of fungal and fungal-like infections, that the full extent of the impact of these pathogens on wild fish populations will soon emerge as a major threat to freshwater biodiversity.

  2. Theoretical study of the source-drain current and gate leakage current to understand the graphene field-effect transistors.

    Science.gov (United States)

    Yu, Cui; Liu, Hongmei; Ni, Wenbin; Gao, Nengyue; Zhao, Jianwei; Zhang, Haoli

    2011-02-28

    We designed acene molecules attached to two semi-infinite metallic electrodes to explore the source-drain current of graphene and the gate leakage current of the gate dielectric material in the field-effect transistors (FETs) device using the first-principles density functional theory combined with the non-equilibrium Green's function formalism. In the acene-based molecular junctions, we modify the connection position of the thiol group at one side, forming different electron transport routes. The electron transport routes besides the shortest one are defined as the cross channels. The simulation results indicate that electron transport through the cross channels is as efficient as that through the shortest one, since the conductance is weakly dependent on the distance. Thus, it is possible to connect the graphene with multiple leads, leading the graphene as a channel utilized in the graphene-based FETs in the mesoscopic system. When the conjugation of the cross channel is blocked, the junction conductance decreases dramatically. The differential conductance of the BA-1 is nearly 7 (54.57 μS) times as large as that of the BA-4 (7.35 μS) at zero bias. Therefore, the blocked graphene can be employed as the gate dielectric material in the top-gated graphene FET device, since the leakage current is small. The graphene-based field-effect transistors fabricated with a single layer of graphene as the channel and the blocked graphene as the gate dielectric material represent one way to overcome the problem of miniaturization which faces the new generation of transistors.

  3. Intra-household allocation of food and health care: current findings and understandings--introduction.

    Science.gov (United States)

    Messer, E

    1997-06-01

    This work offers an anthropological analysis of intra-household processes underlying gender- and age-specific differences in individual nutritional and health care allocations and outcomes in particular cultures. Based on recent ethnographic studies in India, Nepal, Madagascar, Mexico, and Peru, correspondences are analyzed between local cultural ("emic") and scientist-policy maker practitioner ("etic") understandings of nutrition, health, and human development, and the relative "values" of females, males, and children of different ages. The data and analyses clarify specific epidemiological and demographic findings on age and gender bias in nutrition and health and highlight the multiple cultural, economic, and biological factors that contribute to gender- or age-based discrimination or neglect. Recent advances in nutrition policy have argued for a broader concept of nutritional security, one that incorporates both food quantity and quality, and of nutrition as "food, health and care" (International Conference on Nutrition, World Declaration and Plan of Action for Nutrition, FAO/WHO, Rome, 1992). These ethnographic findings; lend strong support for such broader nutrition concepts and associated nutrition policies. The studies also suggest ways in which anthropological questions, methods, and data and community-based research can help predict or identify the nutritionally vulnerable within households and help other social and medical scientists design more effective interventions.

  4. Actuarial senescence in a long-lived orchid challenges our current understanding of ageing.

    Science.gov (United States)

    Dahlgren, Johan Petter; Colchero, Fernando; Jones, Owen R; Øien, Dag-Inge; Moen, Asbjørn; Sletvold, Nina

    2016-11-16

    The dominant evolutionary theory of actuarial senescence-an increase in death rate with advancing age-is based on the concept of a germ cell line that is separated from the somatic cells early in life. However, such a separation is not clear in all organisms. This has been suggested to explain the paucity of evidence for actuarial senescence in plants. We used a 32 year study of Dactylorhiza lapponica that replaces its organs each growing season, to test whether individuals of this tuberous orchid senesce. We performed a Bayesian survival trajectory analysis accounting for reproductive investment, for individuals under two types of land use, in two climatic regions. The mortality trajectory was best approximated by a Weibull model, showing clear actuarial senescence. Rates of senescence in this model declined with advancing age, but were slightly higher in mown plots and in the more benign climatic region. At older ages, senescence was evident only when accounting for a positive effect of reproductive investment on mortality. Our results demonstrate actuarial senescence as well as a survival-reproduction trade-off in plants, and indicate that environmental context may influence senescence rates. This knowledge is crucial for understanding the evolution of demographic senescence and for models of plant population dynamics.

  5. Understanding Gully Formation and Seasonal Flows on Recent and Current Mars

    Science.gov (United States)

    Gulick, Virginia C.; Glines, Natalie

    2016-10-01

    The discoveries of gullies and seasonal slope flows (RSL) have re-ignited the debate over various channel, valley, and gully formation mechanisms on Mars. The controversy over whether liquid water was involved with gully formation, harkens back to the mid-1970s to early 2000s, where catastrophic flooding, surface runnoff and ground-water sapping processes were strongly debated along with other mechanisms as the primary processes responsible for channel and valley formation on Mars. However, over the past decade, the value of multiple working hypotheses has again become apparent, this time in understanding the formation of Martian gullies and Recurring Slope Lineae. Various mechanisms put forth to explain these landforms include liquid H2O/ice erosion, CO2 ice/frost sublimation, CO2 ice block sliding, water and brine flows, salt deliquescence, and dry granular flows, among others.We carried out detailed morphologic/morphometric studies of gullies in various environmental settings on Mars to evaluate the potential formation processes. Using HiRISE images and DTMs, we mapped and generated detailed longitudinal and cross-sectional profiles of gully systems and estimated volumes for both the gullies and their debris aprons. Several gullies form highly integrated patterns similar to fluvial systems. Additionally, RSL are often found either in the tributaries of these integrated systems or in adjacent regions, implying that RSL may play a role in initiating gully formation or mark the last vestiges of water activity in these locations. We also find that the more highly integrated gullies have volumes significantly larger than their aprons, suggesting that the missing volumes (~40-60% or more) were likely the volatiles involved in gully formation. Additionally, THEMIS and TES surface temperatures of these integrated gully sites, many of which also contain RSL, are at or above freezing seasonally suggesting that the volatile component may be consistent with H2O although CO2

  6. Institutional and legal arrangements in the Nile river basin: suggestions to improve the current situation toward adaptive integrated water resources management.

    Science.gov (United States)

    Abdalla, Khalid Mohamed El Hassan

    2008-01-01

    A comparative study was conducted in this work in order to investigate the current situation in the Nile river basin (NRB) regarding the institutional and legal arrangements needed to support the adaptive integrated water resources management (AIWRM) strategy. Two similar river basins were selected to achieve this comparison and to introduce suggestions to reform the current situation in the basin. Before that, the ideal situation is investigated to be as a yardstick for the desired situation. The study indicated that the necessary AIWRM criteria may include regulatory as well as implementation organizations that support shared-vision reaching with its all necessary features (cooperation, stakeholders' participation, subsidiarity, and information and knowledge exchange). Thus the main features of the desired situations regarding AIWRM in river basins are stakeholders' participation, learning-driven ability, quick response to risks and uncertainties, and finally a legal framework that could support these criteria. Although the AIWRM criteria seem to be satisfied in NRB, the basin lacks the necessary regulatory institutions as well as the legal framework. According to this, this study recommends to reform the current situation in NRB by creating regulator institutions (policy and decision making level) as well a legal framework to legitimate them.

  7. Current understanding of the driving mechanisms for spatiotemporal variations of atmospheric speciated mercury: a review

    Science.gov (United States)

    Mao, Huiting; Cheng, Irene; Zhang, Leiming

    2016-10-01

    Atmospheric mercury (Hg) is a global pollutant and thought to be the main source of mercury in oceanic and remote terrestrial systems, where it becomes methylated and bioavailable; hence, atmospheric mercury pollution has global consequences for both human and ecosystem health. Understanding of spatial and temporal variations of atmospheric speciated mercury can advance our knowledge of mercury cycling in various environments. This review summarized spatiotemporal variations of total gaseous mercury or gaseous elemental mercury (TGM/GEM), gaseous oxidized mercury (GOM), and particulate-bound mercury (PBM) in various environments including oceans, continents, high elevation, the free troposphere, and low to high latitudes. In the marine boundary layer (MBL), the oxidation of GEM was generally thought to drive the diurnal and seasonal variations of TGM/GEM and GOM in most oceanic regions, leading to lower GEM and higher GOM from noon to afternoon and higher GEM during winter and higher GOM during spring-summer. At continental sites, the driving mechanisms of TGM/GEM diurnal patterns included surface and local emissions, boundary layer dynamics, GEM oxidation, and for high-elevation sites mountain-valley winds, while oxidation of GEM and entrainment of free tropospheric air appeared to control the diurnal patterns of GOM. No pronounced diurnal variation was found for Tekran measured PBM at MBL and continental sites. Seasonal variations in TGM/GEM at continental sites were attributed to increased winter combustion and summertime surface emissions, and monsoons in Asia, while those in GOM were controlled by GEM oxidation, free tropospheric transport, anthropogenic emissions, and wet deposition. Increased PBM at continental sites during winter was primarily due to local/regional coal and wood combustion emissions. Long-term TGM measurements from the MBL and continental sites indicated an overall declining trend. Limited measurements suggested TGM/GEM increasing from the

  8. New Understanding of Hubble Space Telescope Gyro Current Increase Led to a Method to Save a Failing Gyro Presentation

    Science.gov (United States)

    Blumenstock, Kenneth A.

    2017-01-01

    Throughout the history of the Hubble Space Telescope (HST) program, gyro current increases have been observed to occur, often times leading to gyro failure. The explanation was that debris from the surfaces of the gas bearings, with only 1.27 micron clearance, resulted in rotor restriction, which increased friction, torque, and current. However, the rotor restriction theory never could account for the fact that a restart of the gyro would restore the current back to nominal. An effort was made to understand this puzzling gyro behavior after two HST gyros exhibited increased current within the same week in November 2015. A review board was created to resolve these anomalies and generate operational procedures to potentially extend gyro life. A new understanding of gyro current behavior led to implementation of a method that could potentially save a failing gyro.

  9. The microanatomy of the rectal salt gland of the Port Jackson Shark, Heterodontus portusjacksoni (Meyer) (Heterodontidae): suggestions for a counter-current exchange system.

    Science.gov (United States)

    Newbound, D R; O'Shea, J E

    2001-01-01

    A comprehensive anatomical study was undertaken to examine the rectal salt gland in the Port Jackson shark, Heterodontus portusjacksoni, a shark known to invade estuarine environments. The microstructure and vascular organisation of the rectal salt gland was investigated using histological observation and scanning electron microscopy of vascular corrosion casts. Cellular specialisation was observed in the lining of the central lumen of this gland. This may indicate that there is some modification of the principal product of the gland prior to its secretion. The rectal salt gland has a complex structure related to its function. Contrary to previous reports, the flow in secretory tubules is in the opposite direction to that of the capillaries and thus constitutes a counter-current arrangement. The similarity in the organisation of the counter-current and lobulate arrangement of salt-secreting glands through phylogenetically diverse organisms, such as sharks and birds, suggests that this arrangement is important in achieving efficient salt secretion. Copyright 2001 S. Karger AG, Basel

  10. Parathyroid Carcinoma: Current Understanding and New Insights into Gene Expression and Intraoperative Parathyroid Hormone Kinetics

    OpenAIRE

    Abdelgadir Adam, Mohamed; Untch, Brian R.; Olson, John A.

    2010-01-01

    This review summarizes the current knowledge on parathyroid carcinoma and describes new information on parathyroid carcinoma gene expression and operative management using intraoperative parathyroid hormone monitoring.

  11. Alignment in organisations : does an interpretative perspective lead to a better understanding of the subject? A suggestion for participative self-organisation as a way to improve alignment

    NARCIS (Netherlands)

    Blomme, R.J.; Beasley-Suffolk, A.-M.

    2010-01-01

    This article discusses the concept of alignment and the different domains in which it is used. The standard functionalist perspective on alignment hampers our understanding of this concept. We therefore put forward a social constructionist approach to conducting research into alignment. Using this a

  12. Caustic-based approach to understanding bunching dynamics and current spike formation in particle bunches

    Science.gov (United States)

    Charles, T. K.; Paganin, D. M.; Dowd, R. T.

    2016-10-01

    Current modulations, current spikes, and current horns, are observed in a range of accelerator physics applications including strong bunch compression in Free Electron Lasers and linear colliders, trains of microbunching for terahertz radiation, microbunching instability and many others. This paper considers the fundamental mechanism that drives intense current modulations in dispersive regions, beyond the common explanation of nonlinear and higher-order effects. Under certain conditions, neighboring electron trajectories merge to form caustics, and often result in characteristic current spikes. Caustic lines and surfaces are regions of maximum electron density, and are witnessed in accelerator physics as folds in phase space of accelerated bunches. We identify the caustic phenomenon resulting in cusplike current profiles and derive an expression which describes the conditions needed for particle-bunch caustic formation in dispersive regions. The caustic expression not only reveals the conditions necessary for caustics to form but also where in longitudinal space the caustics will form. Particle-tracking simulations are used to verify these findings. We discuss the broader implications of this work including how to utilize the caustic expression for manipulation of the longitudinal phase space to achieve a desired current profile shape.

  13. Current Understandings of the Research-Practice Gap From the Viewpoint of Complementary Medicine Academics: A Mixed-Method Investigation.

    Science.gov (United States)

    Leach, Matthew J; Tucker, Basil

    Research plays an important role in advancing health and healthcare. However, much research evidence is not reflected in contemporary complementary and alternative medicine (CAM) practice. Understanding and addressing the reasons for this research-practice gap may have positive implications for quality of care. To shed light on the gap between research and CAM practice. Descriptive cross-sectional, mixed-method study. A total of 126 senior CAM academics across Australasia, Europe, UK, and North America. Participants completed a 30-item online survey and a semi-structured interview; both of which explored the research-practice gap in CAM. A total of 43 (34%) academics completed the survey, with 29 (67%) respondents undergoing an interview. There was general agreement among respondents that CAM research should be informed by practice, and practice informed by research; however, most agreed that this did not reflect the current situation. Translational issues were perceived to be the primary reason for the research-practice gap in CAM. Suggested strategies for closing the gap focussed mostly around improving CAM student/practitioner education and training, and researcher-practitioner engagement and collaboration. Study findings point toward the presence of a research-practice gap in CAM, with several factors likely to be instrumental in sustaining this gap. Attention now needs to focus on understanding the views of CAM clinicians on this issue. Insights gained from this research will help inform the development of a multi-modal strategy that will effectively target the barriers to change in order to bring CAM research and practice closer together. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Control of antibiotic resistance in China must not be delayed: The current state of resistance and policy suggestions for the government, medical facilities, and patients.

    Science.gov (United States)

    Tang, Qi; Song, Peipei; Li, Jiajia; Kong, Fanlei; Sun, Long; Xu, Lingzhong

    2016-02-01

    Antibiotics are medicines used to prevent and treat bacterial infections. Antibiotic resistance occurs when bacteria change in response to the use of these medicines. Antibiotic resistance is rising to dangerously high levels in all parts of the world, leading to higher medical costs, prolonged hospital stays, and increased mortality. In the European Union alone, drug-resistant bacteria are estimated to cause 25,000 deaths and cost more than US$1.5 billion every year in healthcare expenses and productivity losses. The problems of antibiotic misuse and antibiotic resistance are quite serious in China. In 2015, results of a study by the State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences indicated that the total antibiotic usage in China in 2013 was approximately 162,000 tons, including human use (48%) and use in animals (52%). This amount accounted for about half of the antibiotic usage worldwide. The per-capita use of antibiotics in China is more than 5 times that in Europe and the United States. These data mean that China is one of the world's leading countries with serious problems in terms of antibiotic misuse and antibiotic resistance. The current article analyzes the current state and harms of antibiotic misuse and causes of antibiotic resistance in China. The Government needs to pay close attention to the issue of antibiotic resistance in China and formulate a strategy at the national level. Thus, the following suggestions are offered: i) The Chinese Government should implement policies that promote antibiotic research and development; ii) Medical facilities in China should create multidisciplinary teams (MDTs) and encourage early action by MDTs to control the spread of multi-drug-resistant bacteria (MDRB); iii) An intervention in the form of health education should target patients and accompanying family members (AFM) in China. In other words, antibiotic resistance is not a personal problem but an

  15. Current understanding of the molecular basis of chloroquine-resistance in Plasmodium falciparum

    Directory of Open Access Journals (Sweden)

    Jiang H

    2006-01-01

    Full Text Available Chloroquine (CQ is the most successful antimalarial drug ever discovered. Unfortunately, parasites resistant to the drug eventually emerged after its large scale use and are now widespread. Although great progress in our understanding of the mechanisms of CQ action and CQ resistance (CQR has been achieved over the past two decades, including the identification of the molecules responsible for CQR (e.g., Plasmodium falciparum chloroquine resistant transporter, PfCRT many questions remain unanswered. Here we highlight recent advances in our understanding of the genetics and molecular mechanisms of CQR, with particular emphasis on the role of genes such as pfcrt and pfmdr1 in the resistance to CQ and other drugs. New drug development and applications will undoubtedly benefit from a better understanding of CQR, eventually leading to more effective malaria control measures.

  16. Current understanding of microplastics in the environment: Occurrence, fate, risks, and what we should do.

    Science.gov (United States)

    Peng, Jinping; Wang, Jundong; Cai, Liqi

    2017-05-01

    Microplastics pollution has been documented in the global environment, including at sea, in freshwater and in atmospheric fallout. Ingestion of microplastics by multiple kinds of organisms has been reported and has received increasing attention, because microplastics not only act as a source of toxic chemicals but also a sink for toxic chemicals. To better understand the great concerns about microplastics and associated toxic chemicals potential exposed to the organisms ingesting the debris, we should know more about the occurrence, fate, and risks of microplastics in the environment. What we should do depends on this better understanding. Integr Environ Assess Manag 2017;13:476-482. © 2017 SETAC. © 2017 SETAC.

  17. Novel therapeutic investigational strategies to treat severe and disseminated HSV infections suggested by a deeper understanding of in vitro virus entry processes.

    Science.gov (United States)

    Clementi, Nicola; Criscuolo, Elena; Cappelletti, Francesca; Burioni, Roberto; Clementi, Massimo; Mancini, Nicasio

    2016-04-01

    The global burden of herpes simplex virus (HSV) legitimates the critical need to develop new prevention strategies, such as drugs and vaccines that are able to fight either primary HSV infections or reactivations. Moreover, the ever-growing number of patients receiving transplants increases the number of severe HSV infections that are unresponsive to current therapies. Finally, the high global incidence of genital HSV-2 infection increases the risk of perinatal transmission to newborns, in which disseminated infection or central nervous system (CNS) involvement is frequent, with associated high morbidity and mortality rates. There are several key features shared by novel anti-HSV drugs, from currently available optimized drugs to small molecules able to interfere with various virus replication steps. However, several virological aspects of the disease and associated clinical needs highlight why an ideal anti-HSV drug has yet to be developed.

  18. The "Current" Commander: Understanding and Effecting Change in Civilian Organizations

    Science.gov (United States)

    2007-03-30

    that can help provide a framework for comprehension and understanding. Leading People Peter Northouse , in Leadership Theory and Practice ... Leadership : Theory and Practice (Thousand Oaks, CA: Sage Publications, Inc., 2003). 152. 11 Ibid., 148. 12 John P. Kotter, Leading Change (Boston...successful leadership and management within hierarchical military organizations. Their practiced and practical experiences using these techniques have

  19. Current as the Key Concept of Taiwanese Students' Understandings of Electric Circuits

    Science.gov (United States)

    Tsai, Chia-Hsing; Chen, Hsueh-Yu; Chou, Ching-Yang; Lain, Kuen-Der

    2007-01-01

    The purpose of this study was to report the results of a nationwide survey of Taiwanese high schools students' understandings about electric circuits. The study involved two stratified random samples consisting of 7,145 students in Grades 8 and 9, and 2,857 students in Grade 11, accounting for about 2.3% of the total enrolment in the corresponding…

  20. Trying to Get Ahead of the Curve: Raising and Understanding Current Themes in New Literacies Practices

    Science.gov (United States)

    Wilber, Dana

    2012-01-01

    This article addresses the following questions: What impact does using the theoretical framework of new literacies have on understanding language, literacy, and learning practices today as technologies are constantly being developed and used? What is the state of research in this area? What are some new directions the field might take in order to…

  1. Greek Primary School Teachers' Understanding of Current Environmental Issues: An Exploration of Their Environmental Knowledge and Images of Nature

    Science.gov (United States)

    Michail, Sirmo; Stamou, Anastasia G.; Stamou, George P.

    2007-01-01

    In this article, the Greek primary school teachers' understanding of three current environmental issues (acid rain, the ozone layer depletion, and the greenhouse effect) as well as the emerging images of nature were examined. The study revealed that teachers held several environmental knowledge gaps and misconceptions about the three phenomena.…

  2. Greek Primary School Teachers' Understanding of Current Environmental Issues: An Exploration of Their Environmental Knowledge and Images of Nature

    Science.gov (United States)

    Michail, Sirmo; Stamou, Anastasia G.; Stamou, George P.

    2007-01-01

    In this article, the Greek primary school teachers' understanding of three current environmental issues (acid rain, the ozone layer depletion, and the greenhouse effect) as well as the emerging images of nature were examined. The study revealed that teachers held several environmental knowledge gaps and misconceptions about the three phenomena.…

  3. Multiculturalism in current tourism: Can tourism and travelling help to improve tolerance and understanding?

    Directory of Open Access Journals (Sweden)

    Josefová Alena

    2016-01-01

    Full Text Available The article focuses on one of the most important issues of the beginning of the 21st century, which is unprecedented move of people. This political, sociological, geographical and psycho-linguistics phenomenon needs qualitatively new approaches in meeting races, cultures, religions, customs and habits. What are the possibilities of cohabitation of people in these new political, cultural and economic conditions? The way can be intercultural exchange characterised by mutual respect and the will to understand otherness and other values.

  4. Human factors implications of vehicle automation: Current understanding and future directions

    NARCIS (Netherlands)

    Merat, N.; de Waard, Dick

    2014-01-01

    Advances in vehicle-based technology are currently progressing at an ever- increasing rate and innovations in this area are no longer restricted to Original Equipment Manufacturers or the automotive industry, with service providers such as Google and a number of research institutes in Europe and Nor

  5. Understanding the catalyst-free transformation of amorphous carbon into graphene by current-induced annealing

    NARCIS (Netherlands)

    Barreiro, A.; Börrnert, F.; Avdoshenko, S.M.; Rellinghaus, B.; Cunibert, G.; Rümmeli, M.H.; Vandersypen, L.M.K.

    2013-01-01

    We shed light on the catalyst-free growth of graphene from amorphous carbon (a–C) by current induced annealing by witnessing the mechanism both with in-situ transmission electron microscopy and with molecular dynamics simulations. Both in experiment and in simulation, we observe that small a–C clust

  6. 海南省观赏水族行业的发展前景及对策%Current Situation of Decorative Fishery in Hainan and Development Suggestions

    Institute of Scientific and Technical Information of China (English)

    张希; 杨宁; 黄海

    2012-01-01

    An important part of recreational fisheries is decorative fishery,which will become a trend in China.Decorative fishery is also an important direction of development in the building process of Hainan international tourism Island.On the base of the deep-going analysis about the current situation of decorative fishery development in Hainan,the main questions of decorative fish cultivation and market were found.At the same time many suggestions were brought up,such as exploiting the biological resources of Hainan Island;Strengthening the efforts of research institutes aquaculture R & D;introducing new varieties of ornamental species;Strengthening market management etc,which will benefit the rational utilization of tropical biological resources and increase a whole competitive advantage of Hainan decorative fishery industry.%观赏水族业是休闲渔业的重要组成部分,海南具有大力发展热带观赏水族行业的潜力。对海南省观赏水族市场进行深入调查,分析和总结海南省观赏水族行业的发展现状和存在的问题,提出发挥海南区位优势、挖掘本地热带生物资源、加强科研力量、引进国外观赏水族新品种、加强产业引导和市场管理等建议,促进热带生物资源的合理利用和观赏水族业结构的多元化,增加海南省观赏水族业的整体竞争优势。

  7. Gold deposits in metamorphic belts: Overview of current understanding, outstanding problems, future research, and exploration significance

    Science.gov (United States)

    Groves, D.I.; Goldfarb, R.J.; Robert, F.; Hart, C.J.R.

    2003-01-01

    Metamorphic belts are complex regions where accretion or collision has added to, or thickened, continental crust. Gold-rich deposits can be formed at all stages of orogen evolution, so that evolving metamorphic belts contain diverse gold deposit types that may be juxtaposed or overprint each other. This partly explains the high level of controversy on the origin of some deposit types, particularly those formed or overprinted/remobilized during the major compressional orogeny that shaped the final geometry of the hosting metamorphic belts. These include gold-dominated orogenic and intrusion-related deposits, but also particularly controversial gold deposits with atypical metal associations. There are a number of outstanding problems for all types of gold deposits in metamorphc belts. These include the following: (1) definitive classifications, (2) unequivocal recognition of fluid and metal sources, (3) understanding of fluid migration and focusing at all scales, (4) resolution of the precise role of granitoid magmatism, (5) precise gold-depositional mechanisms, particularly those producing high gold grades, and (6) understanding of the release of CO2-rich fluids from subducting slabs and subcreted oceanic crust and granitoid magmas at different crustal levels. Research needs to be better coordinated and more integrated, such that detailed fluid-inclusion, trace-element, and isotopic studies of both gold deposits and potential source rocks, using cutting-edge technology, are embedded in a firm geological framework at terrane to deposit scales. Ultimately, four-dimensional models need to be developed, involving high-quality, three-dimensional geological data combined with integrated chemical and fluid-flow modeling, to understand the total history of the hydrothermal systems involved. Such research, particularly that which can predict superior targets visible in data sets available to exploration companies before discovery, has obvious spin-offs for global- to deposit

  8. Current Understanding on Aflatoxin Biosynthesis and Future Perspective in Reducing Aflatoxin Contamination

    Science.gov (United States)

    Yu, Jiujiang

    2012-01-01

    Traditional molecular techniques have been used in research in discovering the genes and enzymes that are involved in aflatoxin formation and genetic regulation. We cloned most, if not all, of the aflatoxin pathway genes. A consensus gene cluster for aflatoxin biosynthesis was discovered in 2005. The factors that affect aflatoxin formation have been studied. In this report, the author summarized the current status of research progress and future possibilities that may be used for solving aflatoxin contamination. PMID:23202305

  9. Current Understanding on Aflatoxin Biosynthesis and Future Perspective in Reducing Aflatoxin Contamination

    OpenAIRE

    2012-01-01

    Traditional molecular techniques have been used in research in discovering the genes and enzymes that are involved in aflatoxin formation and genetic regulation. We cloned most, if not all, of the aflatoxin pathway genes. A consensus gene cluster for aflatoxin biosynthesis was discovered in 2005. The factors that affect aflatoxin formation have been studied. In this report, the author summarized the current status of research progress and future possibilities that may be used for solving afla...

  10. Caring for Machado-Joseph Disease: current understanding and how to help patients

    OpenAIRE

    D’Abreu, Anelyssa; França, Marcondes C.; Paulson, Henry L.; Lopes-Cendes,Iscia

    2009-01-01

    Machado-Joseph disease or spinocerebellar ataxia 3 (MJD/SCA3) is a clinically heterogeneous, neurodegenerative disorder characterized by varying degrees of ataxia, ophthalmoplegia, peripheral neuropathy, pyramidal dysfunction and movement disorder. MJD/SCA3 is caused by a CAG repeat expansion mutation in the protein coding region of the ATXN3 gene located at chromosome 14q32.1. Current hypotheses regarding pathogenesis favor the view that mutated ataxin-3, with its polyglutamine expansion, is...

  11. Current Understanding of Molecular Pathology and Treatment of Cardiomyopathy in Duchenne Muscular Dystrophy

    Directory of Open Access Journals (Sweden)

    Tirsa L. E. van Westering

    2015-05-01

    Full Text Available Duchenne muscular dystrophy (DMD is a genetic muscle disorder caused by mutations in the Dmd gene resulting in the loss of the protein dystrophin. Patients do not only experience skeletal muscle degeneration, but also develop severe cardiomyopathy by their second decade, one of the main causes of death. The absence of dystrophin in the heart renders cardiomyocytes more sensitive to stretch-induced damage. Moreover, it pathologically alters intracellular calcium (Ca2+ concentration, neuronal nitric oxide synthase (nNOS localization and mitochondrial function and leads to inflammation and necrosis, all contributing to the development of cardiomyopathy. Current therapies only treat symptoms and therefore the need for targeting the genetic defect is immense. Several preclinical therapies are undergoing development, including utrophin up-regulation, stop codon read-through therapy, viral gene therapy, cell-based therapy and exon skipping. Some of these therapies are undergoing clinical trials, but these have predominantly focused on skeletal muscle correction. However, improving skeletal muscle function without addressing cardiac aspects of the disease may aggravate cardiomyopathy and therefore it is essential that preclinical and clinical focus include improving heart function. This review consolidates what is known regarding molecular pathology of the DMD heart, specifically focusing on intracellular Ca2+, nNOS and mitochondrial dysregulation. It briefly discusses the current treatment options and then elaborates on the preclinical therapeutic approaches currently under development to restore dystrophin thereby improving pathology, with a focus on the heart.

  12. Current understanding of the neurobiology and longitudinal course of geriatric depression.

    Science.gov (United States)

    Weisenbach, Sara L; Kumar, Anand

    2014-09-01

    Late life depression is a complex disease associated with a number of contributing neurobiological factors, including cerebrovascular disease, neurodegeneration, and inflammation, which also contribute to its longitudinal prognosis and course. These factors create a context in which the brain is more vulnerable to the impact of stress, and thus, to depression. At the same time, some individuals are protected from late life depression and its consequences, even in the face of neurobiological vulnerability, through benefitting from one or more attributes associated with resilience, including social support, engagement in physical and cognitive activities, and brain reserve. Enhanced understanding of how neurobiological and environmental factors interact in predicting vulnerability and resilience is needed to predict onset and course of depression in late life and develop more effective interventions.

  13. Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis.

    Science.gov (United States)

    Ferguson, Polly J; Sandu, Monica

    2012-04-01

    Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory disorder that primarily affects children. Its hallmark is recurring episodes of sterile osteomyelitis. The clinical presentation is insidious onset of bone pain with or without fever. Laboratory studies typically reveal nonspecific evidence of inflammation. Radiologic imaging and histologic appearance resemble those of infectious osteomyelitis. There is a strong association with inflammatory disorders of the skin and intestinal tract in affected individuals and their close relatives, suggesting a shared pathophysiology and supporting a genetic component to disease susceptibility. Two genetic syndromes have CRMO as a prominent phenotype-Majeed syndrome and deficiency of the interleukin-1 receptor antagonist-and suggest that interleukin-1 may be a key cytokine in disease pathogenesis. This review briefly summarizes the main clinical and radiologic aspects of the disease and then focuses on genetics and pathophysiology and provides an update on treatment.

  14. Therapeutic Mechanisms of Lithium in Bipolar Disorder: Recent Advances and Current Understanding.

    Science.gov (United States)

    Malhi, Gin S; Outhred, Tim

    2016-10-01

    Lithium is the most effective and well established treatment for bipolar disorder, and it has a broad array of effects within cellular pathways. However, the specific processes through which therapeutic effects occur and are maintained in bipolar disorder remain unclear. This paper provides a timely update to an authoritative review of pertinent findings that was published in CNS Drugs in 2013. A literature search was conducted using the Scopus database, and was limited by year (from 2012). There has been a resurgence of interest in lithium therapy mechanisms, perhaps driven by technical advancements in recent years that permit the examination of cellular mechanisms underpinning the effects of lithium-along with the reuptake of lithium in clinical practice. Recent research has further cemented glycogen synthase kinase 3β (GSK3β) inhibition as a key mechanism, and the inter-associations between GSK3β-mediated neuroprotective, anti-oxidative and neurotransmission mechanisms have been further elucidated. In addition to highly illustrative cellular research, studies examining higher-order biological systems, such as circadian rhythms, as well as employing innovative animal and human models, have increased our understanding of how lithium-induced changes at the cellular level possibly translate to changes at behavioural and clinical levels. Neural circuitry research is yet to identify clear mechanisms of change in bipolar disorder in response to treatment with lithium, but important structural findings have demonstrated links to the modulation of cellular mechanisms, and peripheral marker and pharmacogenetic studies are showing promising findings that will likely inform the exploration for predictors of lithium treatment response. With a deeper understanding of lithium's therapeutic mechanisms-from the cellular to clinical levels of investigation-comes the opportunity to develop predictive models of lithium treatment response and identify novel drug targets, and

  15. Current understanding of TRPM7 pharmacology and drug development for stroke

    Institute of Scientific and Technical Information of China (English)

    Christine You Jin BAE; Hong-shuo SUN

    2013-01-01

    The initial excitement and counties efforts to find a pharmacological agent that disrupts the excitotoxic pathway of ischemic neuronal death have only led to disappointing clinical trials.Currently,a thrombolytic agent called recombinant tissue plasminogen activator (rtPA) is the only pharmacological treatment available for patients with acute ischemic stroke in most countries.Even though its efficacy has been confirmed repeatedly,rt-PA is considerably underused due to reasons including a short therapeutic window and repeated complications associated with its use.A search for alternative mechanisms that may operate dependently or independently with the well-established excitotoxic mechanism has led researchers to the discovery of newly described non-glutamate mechanisms.Among the latter,transient receptor potential melastatin 7 (TRPM7) is one of the important nonglutamate mechanisms in stroke,which has been evaluated in both in-vitro and in-vivo.In this review,we will discuss the current state of pharmacological treatments of ischemic stroke and provide evidence that TRPM7 is a promising therapeutic target of stroke.

  16. Understanding the current status and exploring the potential for distance education in public health in India.

    Science.gov (United States)

    Sharma, Kavya; George, Sunil; Zodpey, Sanjay

    2011-01-01

    Continuing education of health care providers plays an important role in producing a health work force that is efficient and effective. In India public health education has primarily relied on conventional methods of training. However, such methods have limitations in equipping the health workforce of a vast and varied country like India. This paper analyzes the current status of distance education in public health and lists the various courses that are presently available in India through the distance education mode. Presently 25 institutions in India are offering 69 courses in various domains of public health through distance education. The providers of these programs comprised both government and private educational institutions. This paper also points out the role and importance of various stakeholders in the design and delivery of distance education programs in public health and raises key areas that need attention in the governance of such programs. It urges the use of digital technology in the delivery of distance education programs and points out how distance education that is designed and delivered using the latest technology could address the current gap in training human resources for health in India.

  17. New Understanding of Hubble Space Telescope Gyro Current Increase Led to a Method to Save a Failing Gyro

    Science.gov (United States)

    Blumenstock, Kenneth A.

    2017-01-01

    Throughout the history of the Hubble Space Telescope (HST) program, gyro current increases have been observed to occur, oftentimes leading to gyro failure. The explanation was that debris from the surfaces of the gas bearings, with only 50 millionths on an inch clearance, resulted in rotor restriction, which increased friction, torque, and current. However, the rotor restriction theory never could account for the fact that a restart of the gyro would restore the current back to nominal. An effort was made to understand this puzzling gyro behavior after two HST gyros exhibited increased current within the same week in November 2015. A review board was created to resolve these anomalies and generate operational procedures to potentially extend gyro life.

  18. The Hyaluronic Acid Fillers: Current Understanding of the Tissue Device Interface.

    Science.gov (United States)

    Greene, Jacqueline J; Sidle, Douglas M

    2015-11-01

    The article is a detailed update regarding cosmetic injectable fillers, specifically focusing on hyaluronic acid fillers. Hyaluronic acid-injectable fillers are used extensively for soft tissue volumizing and contouring. Many different hyaluronic acid-injectable fillers are available on the market and differ in terms of hyaluronic acid concentration, particle size, cross-linking density, requisite needle size, duration, stiffness, hydration, presence of lidocaine, type of cross-linking technology, and cost. Hyaluronic acid is a natural component of many soft tissues, is identical across species minimizing immunogenicity has been linked to wound healing and skin regeneration, and is currently actively being studied for tissue engineering purposes. The biomechanical and biochemical effects of HA on the local microenvironment of the injected site are key to its success as a soft tissue filler. Knowledge of the tissue-device interface will help guide the facial practitioner and lead to optimal outcomes for patients.

  19. Changing currents: a strategy for understanding and predicting the changing ocean circulation.

    Science.gov (United States)

    Bryden, Harry L; Robinson, Carol; Griffiths, Gwyn

    2012-12-13

    Within the context of UK marine science, we project a strategy for ocean circulation research over the next 20 years. We recommend a focus on three types of research: (i) sustained observations of the varying and evolving ocean circulation, (ii) careful analysis and interpretation of the observed climate changes for comparison with climate model projections, and (iii) the design and execution of focused field experiments to understand ocean processes that are not resolved in coupled climate models so as to be able to embed these processes realistically in the models. Within UK-sustained observations, we emphasize smart, cost-effective design of the observational network to extract maximum information from limited field resources. We encourage the incorporation of new sensors and new energy sources within the operational environment of UK-sustained observational programmes to bridge the gap that normally separates laboratory prototype from operational instrument. For interpreting the climate-change records obtained through a variety of national and international sustained observational programmes, creative and dedicated UK scientists should lead efforts to extract the meaningful signals and patterns of climate change and to interpret them so as to project future changes. For the process studies, individual scientists will need to work together in team environments to combine observational and process modelling results into effective improvements in the coupled climate models that will lead to more accurate climate predictions.

  20. Understanding the Neuro-ophthalmology of Head Trauma: A Review of the Current Literature.

    Science.gov (United States)

    Samra, Khawla Abu

    2014-01-01

    Head trauma is a major medical, social, economic, national, and public health priority issue in the United States. In severe head trauma, the overwhelming clinical manifestations are so compelling that damage to the visual system is most likely to be ignored. Both the afferent and efferent visual systems are susceptible to injury after head trauma, and physicians should be aware of the visual system and perform a thorough neuro-ophthalmic evaluation in patients presenting with head trauma.Most of the data available on neuro-ophthalmic complications of head trauma including cortical blindness, Horner's syndrome, traumatic internuclear ophthalmoplegia, and ocular motor palsy, comes from case reports highlighting the need for future studies to better understand these complications.This review summarizes some of the most important neuro-ophthalmic complications of head trauma including cortical blindness, Horner's syndrome, traumatic internuclear ophthalmoplegia, and ocular motor palsy. Search of the peer-reviewed literature was conducted using MEDLINE, Cumulative Index to Nursing and Allied Health Literature, Cochrane Library, Global Health, and MD Consult.

  1. Current understanding of dystrophin-related muscular dystrophy and therapeutic challenges ahead

    Institute of Scientific and Technical Information of China (English)

    ZHOU Guang-qian; XIE Hui-qi; ZHANG Su-zhen; YANG Zhi-ming

    2006-01-01

    Objective To review the recent research progress in dystrophin-related muscular dystrophy includes X-linked hereditary Duchenne and Becker muscular dystrophies (DMD and BMD).Data sources Information included in this article was identified by searches of PUBMED and other online resources using the key terms DMD, dystrophin, mutations, animal models, pathophysiology, gene expression, stem cells, gene therapy, cell therapy, and pharmacological.Study selection Mainly original milestone articles and timely reviews written by major pioneer investigators of the field were selected.Results The key issues related to the genetic basis and pathophysiological factors of the diseases were critically addressed. The availabilities and advantages of various animal models for the diseases were described. Major molecular and cellular therapeutic approaches were also discussed, many of which have indeed exhibited some success in pre-clinical studies but at the same time encountered a number of technical hurdles, including the efficient and systemic delivery of a functional gene and myogenic precursor/stem cells to repair genetic defects.Conclusions Further understanding of pathophysiological mechanisms at molecular levels and regenerative properites of myogenic precursor/stem cells will promote the development of multiple therapeutic strategies. The combined use of multiple strategies may represent the major challenge as well as the greatest hope for the therapy of these diseases in coming years.

  2. Mini-review: Current Understanding of the Correlation of Lignin Structure with Biomass Recalcitrance

    Science.gov (United States)

    Li, Mi; Pu, Yunqiao; Ragauskas, Arthur

    2016-11-01

    Lignin, a complex aromatic polymer in terrestrial plants, contributes significantly to biomass recalcitrance to microbial and/or enzymatic deconstruction. To reduce biomass recalcitrance, substantial endeavors have been exerted on pretreatment and lignin engineering in the past few decades. Lignin removal and/or alteration of lignin structure have been shown to result in reduced biomass recalcitrance with improved cell wall digestibility. While high lignin content is usually a barrier to a cost-efficient application of bioresource to biofuels, the direct correlation of lignin structure and its concomitant properties with biomass remains unclear due to the complexity of cell wall and lignin structure. Advancement in application of biorefinery to production of biofuels, chemicals, and biomaterials necessitates a fundamental understanding of the relationship of lignin structure and biomass recalcitrance. In this mini-review, we focus on recent investigations on the influence of lignin chemical properties on bioprocessability— pretreatment and enzymatic hydrolysis of biomass. Specifically, lignin-enzyme interaction and the effects of lignin compositional units, hydroxycinnamates, and lignin functional groups on biomass recalcitrance have been highlighted, which will be useful not only in addressing biomass recalcitrance but also in deploying renewable lignocelluloses efficiently.

  3. Current Understanding of the Role of Complement in IgA Nephropathy

    Science.gov (United States)

    Maillard, Nicolas; Wyatt, Robert J.; Julian, Bruce A.; Kiryluk, Krzysztof; Gharavi, Ali; Fremeaux-Bacchi, Veronique

    2015-01-01

    Complement activation has a role in the pathogenesis of IgA nephropathy, an autoimmune disease mediated by pathogenic immune complexes consisting of galactose-deficient IgA1 bound by antiglycan antibodies. Of three complement-activation pathways, the alternative and lectin pathways are involved in IgA nephropathy. IgA1 can activate both pathways in vitro, and pathway components are present in the mesangial immunodeposits, including properdin and factor H in the alternative pathway and mannan-binding lectin, mannan–binding lectin–associated serine proteases 1 and 2, and C4d in the lectin pathway. Genome–wide association studies identified deletion of complement factor H–related genes 1 and 3 as protective against the disease. Because the corresponding gene products compete with factor H in the regulation of the alternative pathway, it has been hypothesized that the absence of these genes could lead to more potent inhibition of complement by factor H. Complement activation can take place directly on IgA1–containing immune complexes in circulation and/or after their deposition in the mesangium. Notably, complement factors and their fragments may serve as biomarkers of IgA nephropathy in serum, urine, or renal tissue. A better understanding of the role of complement in IgA nephropathy may provide potential targets and rationale for development of complement-targeting therapy of the disease. PMID:25694468

  4. Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses

    Directory of Open Access Journals (Sweden)

    Victor Fattori

    2016-06-01

    Full Text Available In this review, we discuss the importance of capsaicin to the current understanding of neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We will focus on the analgesic effects of capsaicin and its clinical applicability in treating pain. Furthermore, we will draw attention to the rationale for other clinical therapeutic uses and implications of capsaicin in diseases such as obesity, diabetes, cardiovascular conditions, cancer, airway diseases, itch, gastric, and urological disorders.

  5. Actuarial senescence in a long-lived orchid challenges our current understanding of ageing

    DEFF Research Database (Denmark)

    Dahlgren, Johan; Colchero, Fernando; Jones, Owen

    2016-01-01

    The dominant evolutionary theory of actuarial senescence – an increase in death rate with advancing age – is based on the concept of a germ cell line that is separated from the somatic cells early in life. However, such a separation is not clear in all organisms. This has been suggested to explain...... the paucity of evidence for actuarial senescence in plants. We used a 32-year study of Dactylorhiza lapponica that replaces its organs each growing season, to test whether individuals of this tuberous orchid senesce. We performed a Bayesian survival trajectory analysis accounting for reproductive investment......, for individuals under two types of land-use, in two climatic regions. The mortality trajectory was best-approximated by a Weibull model, showing clear actuarial senescence. Rates of senescence in this model declined with advancing age, but were slightly higher in mown plots and in the more benign climatic region...

  6. Actuarial senescence in a long-lived orchid challenges our current understanding of ageing

    DEFF Research Database (Denmark)

    Dahlgren, Johan; Colchero, Fernando; Jones, Owen;

    2016-01-01

    The dominant evolutionary theory of actuarial senescence – an increase in death rate with advancing age – is based on the concept of a germ cell line that is separated from the somatic cells early in life. However, such a separation is not clear in all organisms. This has been suggested to explain...... the paucity of evidence for actuarial senescence in plants. We used a 32-year study of Dactylorhiza lapponica that replaces its organs each growing season, to test whether individuals of this tuberous orchid senesce. We performed a Bayesian survival trajectory analysis accounting for reproductive investment......, for individuals under two types of land-use, in two climatic regions. The mortality trajectory was best-approximated by a Weibull model, showing clear actuarial senescence. Rates of senescence in this model declined with advancing age, but were slightly higher in mown plots and in the more benign climatic region...

  7. The Solar Wind: Our Current Understanding and How We Got Here

    Indian Academy of Sciences (India)

    Joseph V. Hollweg

    2008-03-01

    In the original theory for the solar wind, the electron pressure gradient was the principal accelerating force. This was soon recognized to be insufficient to drive the high-speed streams. Subsequently, the discovery of Alfvén waves in the solar wind led to a long series of models in which wave pressure provided additional acceleration, but these wave-driven models ultimately failed to explain the rapid acceleration of the fast wind close to the Sun. An alternate viewwas that the pressure of hot protons close to the Sun could explain the rapid acceleration, with the proton heating coming from the cyclotron resonance. SOHO has provided remarkable data which have verified some of the predictions of this view, and given impetus to ongoing studies of the ion-cyclotron resonance in the fast wind. After a historical review, we discuss the basic ideas behind current research, emphasizing the importance of particle kinetics. We conclude with some guesses as to how work might proceed in the future.

  8. Studying the start of the Maunder Minimum to understand the current situation

    Science.gov (United States)

    Neuhäuser, Ralph; Neuhäuser, Dagmar L.

    2016-04-01

    To investigate whether we now enter a Maunder-like grand minimum, we have to compare the current situation with the time around the start of the Maunder minimum. Sunspot observations in the 1610s are of particular importance and relevance, because they are shortly before the start of the Maunder Grand Minimum. While the Maunder Minimum it is usually dated from 1645 to 1715, Vaquero & Trigo (2015) argue that what they call the "Extended Maunder Minimum" would have started in 1618 during or around a Schwabe cycle minimum around that time. We have therefore studied the sunspot record of that time in detail. Hoyt & Schatten (1998) compiled for all known telescopic observers a list of their observations; recent solar activity studies for the past four centuries are based on their compilation. In addition to 12 observers listed by Hoyt & Schatten (1998) for the 1610s, we list six more observers with datable spot observations. Furthermore, while Hoyt & Schatten (1998) argue that Simon Marius would have observed from mid 1617 to the end of 1618 almost every day, but would have never seen a spot, we can show with the original reports by Marius that he observed from Aug 1611 to spring 1619 with a lot of sunspot detections. Similar, while Hoyt & Schatten (1998) argue that Giovanni Riccioli would have observed on almost every day in 1618, but would have never seen a spot, he did not report any own observations at all that year, but quoted Argoli for that there were no spots during the periods with comets in 1618. The data base by Hoyt & Schatten (1998) has several more errors in the 1610s, as we show also for the observations by Harriot, Scheiner, Malapert, Saxonius, and Tarde. We also compare drawings from Jungius with the observations by Harriot, Galilei, and Marius. In contrast to what is specified in Hoyt & Schatten (1998), after Harriot, the two Fabricius (father and son), Scheiner and Cysat, Marius and Schmidnerus are among the earliest datable telescopic sunspot

  9. Current understanding of the mechanism of action of the antiepileptic drug lacosamide.

    Science.gov (United States)

    Rogawski, Michael A; Tofighy, Azita; White, H Steve; Matagne, Alain; Wolff, Christian

    2015-02-01

    The antiepileptic drug lacosamide [(R)-2-acetamido-N-benzyl-3-methoxypropanamide], a chiral functionalized amino acid, was originally identified by virtue of activity in the mouse and rat maximal electroshock (MES) test. Attention was drawn to lacosamide because of its high oral potency and stereoselectivity. Lacosamide is also active in the 6 Hz seizure model but inactive against clonic seizures in rodents induced by subcutaneous pentylenetetrazol, bicuculline and picrotoxin. It is also ineffective in genetic models of absence epilepsy. At doses greater than those required to confer protection in the MES test, lacosamide inhibits behavioral and electrographic seizures in hippocampal kindled rats. It also effectively terminates seizures in the rat perforant path stimulation status epilepticus model when administered early after the onset of seizures. Lacosamide does not exhibit antiepileptogenic effects in kindling or post-status epilepticus models. The profile of lacosamide in animal seizure and epilepsy models is similar to that of sodium channel blocking antiepileptic drugs, such as phenytoin and carbamazepine. However, unlike these agents, lacosamide does not affect sustained repetitive firing (SRF) on a time scale of hundreds of milliseconds or affect fast inactivation of voltage-gated sodium channels; however, it terminates SRF on a time scale of seconds by an apparent effect on sodium channel slow inactivation. Lacosamide shifts the slow inactivation curve to more hyperpolarized potentials and enhances the maximal fraction of channels that are in the slow inactivated state. Currently, lacosamide is the only known antiepileptic drug in clinical practice that exerts its anticonvulsant activity predominantly by selectively enhancing slow sodium channel inactivation.

  10. Polar mesosphere summer echoes (PMSE: Review of observations and current understanding

    Directory of Open Access Journals (Sweden)

    M. Rapp

    2004-01-01

    Full Text Available Polar mesosphere summer echoes (PMSE are very strong radar echoes primarily studied in the VHF wavelength range from altitudes close to the polar summer mesopause. Radar waves are scattered at irregularities in the radar refractive index which at mesopause altitudes is effectively determined by the electron number density. For efficient scatter, the electron number density must reveal structures at the radar half wavelength (Bragg condition for monostatic radars; ~3 m for typical VHF radars. The question how such small scale electron number density structures are created in the mesopause region has been a longstanding open scientific question for almost 30 years. This paper reviews experimental and theoretical milestones on the way to an advanced understanding of PMSE. Based on new experimental results from in situ observations with sounding rockets, ground based observations with radars and lidars, numerical simulations with microphysical models of the life cycle of mesospheric aerosol particles, and theoretical considerations regarding the diffusivity of electrons in the ice loaded complex plasma of the mesopause region, a consistent explanation for the generation of these radar echoes has been developed. The main idea is that mesospheric neutral air turbulence in combination with a significantly reduced electron diffusivity due to the presence of heavy charged ice aerosol particles (radii ~5–50 nm leads to the creation of structures at spatial scales significantly smaller than the inner scale of the neutral gas turbulent velocity field itself. Importantly, owing to their very low diffusivity, the plasma structures acquire a very long lifetime, i.e., 10 min to hours in the presence of particles with radii between 10 and 50 nm. This leads to a temporal decoupling of active neutral air turbulence and the existence of small scale plasma structures and PMSE and thus readily explains observations proving the absence of neutral air turbulence at

  11. Osteoradionecrosis of the jaws: current understanding of its pathophysiology and treatment.

    Science.gov (United States)

    Lyons, Andrew; Ghazali, Naseem

    2008-12-01

    During the past 80 years a number of theories about the pathogenesis of osteoradionecrosis (ORN) have been proposed, with consequent implications for its treatment. Until recently tissue hypoxia and its consequences were accepted as the primary cause, and this led to the use of hyperbaric oxygen (HBO) for both treatment and prevention of complications of radiotherapy in the head and neck. The benefit of HBO has not been validated. A new theory for the pathogenesis of ORN has proposed that damage to bone is caused by radiation-induced fibrosis. Cells in bone are damaged as a result of acute inflammation, free radicals, and the chronic activation of fibroblasts by a series of growth factors. New treatments have therefore been devised that include pentoxifylline, a vasodilator that also inhibits fibrosis, and tocopherol (vitamin E) to reduce damage caused by free radicals. Impressive results in terms of reversing the process of ONR have been reported using these agents. It has been suggested that this theory and these agents could be the basis of future treatment and prevention of ORN.

  12. Current understandings and perspectives on non-cancer health effects of benzene: A global concern

    Energy Technology Data Exchange (ETDEWEB)

    Bahadar, Haji [International Campus, Tehran University of Medical Sciences (Iran, Islamic Republic of); Pharmaceutical Sciences Research Center and Faculty of Pharmacy, Tehran University of Medical Sciences (Iran, Islamic Republic of); Mostafalou, Sara [Pharmaceutical Sciences Research Center and Faculty of Pharmacy, Tehran University of Medical Sciences (Iran, Islamic Republic of); Abdollahi, Mohammad, E-mail: Mohammad.Abdollahi@UToronto.Ca [Pharmaceutical Sciences Research Center and Faculty of Pharmacy, Tehran University of Medical Sciences (Iran, Islamic Republic of)

    2014-04-15

    Objective: Benzene, as a volatile organic compound, is known as one of the main air pollutants in the environment. The aim of this review is to summarize all available evidences on non-cancerous health effects of benzene providing an overview of possible association of exposure to benzene with human chronic diseases, specially, in those regions of the world where benzene concentration is being poorly monitored. Methodology: A bibliographic search of scientific databases including PubMed, Google Scholar, and Scirus was conducted with key words of “benzene toxic health effects”, “environmental volatile organic compounds”, “diabetes mellitus and environmental pollutants”, “breast cancer and environmental pollution”, “prevalence of lung cancer”, and “diabetes prevalence”. More than 300 peer reviewed papers were examined. Experimental and epidemiologic studies reporting health effects of benzene and volatile organic compounds were included in the study. Results: Epidemiologic and experimental studies suggest that benzene exposure can lead to numerous non-cancerous health effects associated with functional aberration of vital systems in the body like reproductive, immune, nervous, endocrine, cardiovascular, and respiratory. Conclusion: Chronic diseases have become a health burden of global dimension with special emphasis in regions with poor monitoring over contents of benzene in petrochemicals. Benzene is a well known carcinogen of blood and its components, but the concern of benzene exposure is more than carcinogenicity of blood components and should be evaluated in both epidemiologic and experimental studies. Aspect of interactions and mechanism of toxicity in relation to human general health problems especially endocrine disturbances with particular reference to diabetes, breast and lung cancers should be followed up. - Highlights: • Benzene is a volatile organic compound and established blood carcinogen. • Exposure to benzene needs to be

  13. Advancing Implementation of Evidence-Based Public Health in China: An Assessment of the Current Situation and Suggestions for Developing Regions.

    Science.gov (United States)

    Shi, Jianwei; Jiang, Chenghua; Tan, Duxun; Yu, Dehua; Lu, Yuan; Sun, Pengfei; Pan, Ying; Zhang, Hanzhi; Wang, Zhaoxin; Yang, Beilei

    2016-01-01

    Objective. Existing research shows a serious scarcity of EBPH practice in China and other developing regions; as an exploratory study, this study aimed to assess the current EBPH implementation status in Shanghai of China qualitatively. Methods. Using semistructured key informant interviews, we examined the status of and impediments to the lagging EBPH in China. Data were analyzed based on the Consolidated Framework for Implementation Research (CFIR). Results. Chinese public health practitioners knew more about evidence-based medicine but less about EBPH. The situation was worse in community healthcare centers. Participants perceived that evidence sources were limited and the quality of evidence was low. Concerning the inner setting factors, the structural characteristics, networks and communications, implementation climate, and leadership engagement were confronted with many problems. Among the outer setting factors, external government policies and incentives and low patient compliance were the key problems. Additionally, public health practitioners in Shanghai lacked sufficient awareness of EBPH. Furthermore, the current project-based EBPH lacks a systematic implementation system. Conclusions. Existing practical perspectives on EBPH indicate a lag in the advocacy of this new ideology in China. It would be advisable for healthcare institutions to take the initiative to explore feasible and multiple methods of EBPH promotion.

  14. Advancing Implementation of Evidence-Based Public Health in China: An Assessment of the Current Situation and Suggestions for Developing Regions

    Directory of Open Access Journals (Sweden)

    Jianwei Shi

    2016-01-01

    Full Text Available Objective. Existing research shows a serious scarcity of EBPH practice in China and other developing regions; as an exploratory study, this study aimed to assess the current EBPH implementation status in Shanghai of China qualitatively. Methods. Using semistructured key informant interviews, we examined the status of and impediments to the lagging EBPH in China. Data were analyzed based on the Consolidated Framework for Implementation Research (CFIR. Results. Chinese public health practitioners knew more about evidence-based medicine but less about EBPH. The situation was worse in community healthcare centers. Participants perceived that evidence sources were limited and the quality of evidence was low. Concerning the inner setting factors, the structural characteristics, networks and communications, implementation climate, and leadership engagement were confronted with many problems. Among the outer setting factors, external government policies and incentives and low patient compliance were the key problems. Additionally, public health practitioners in Shanghai lacked sufficient awareness of EBPH. Furthermore, the current project-based EBPH lacks a systematic implementation system. Conclusions. Existing practical perspectives on EBPH indicate a lag in the advocacy of this new ideology in China. It would be advisable for healthcare institutions to take the initiative to explore feasible and multiple methods of EBPH promotion.

  15. Advancing Implementation of Evidence-Based Public Health in China: An Assessment of the Current Situation and Suggestions for Developing Regions

    Science.gov (United States)

    Shi, Jianwei; Tan, Duxun; Yu, Dehua; Lu, Yuan; Sun, Pengfei; Pan, Ying; Zhang, Hanzhi; Yang, Beilei

    2016-01-01

    Objective. Existing research shows a serious scarcity of EBPH practice in China and other developing regions; as an exploratory study, this study aimed to assess the current EBPH implementation status in Shanghai of China qualitatively. Methods. Using semistructured key informant interviews, we examined the status of and impediments to the lagging EBPH in China. Data were analyzed based on the Consolidated Framework for Implementation Research (CFIR). Results. Chinese public health practitioners knew more about evidence-based medicine but less about EBPH. The situation was worse in community healthcare centers. Participants perceived that evidence sources were limited and the quality of evidence was low. Concerning the inner setting factors, the structural characteristics, networks and communications, implementation climate, and leadership engagement were confronted with many problems. Among the outer setting factors, external government policies and incentives and low patient compliance were the key problems. Additionally, public health practitioners in Shanghai lacked sufficient awareness of EBPH. Furthermore, the current project-based EBPH lacks a systematic implementation system. Conclusions. Existing practical perspectives on EBPH indicate a lag in the advocacy of this new ideology in China. It would be advisable for healthcare institutions to take the initiative to explore feasible and multiple methods of EBPH promotion. PMID:27597958

  16. An Official American Thoracic Society Research Statement: Current Understanding and Future Research Needs in Tobacco Control and Treatment.

    Science.gov (United States)

    Leone, Frank T; Carlsen, Kai-Hakon; Folan, Patricia; Latzka, Karen; Munzer, Alfred; Neptune, Enid; Pakhale, Smita; Sachs, David P L; Samet, Jonathan; Upson, Dona; White, Alexander

    2015-08-01

    Since the mid-20th century, the scientific community has substantially improved its understanding of the worldwide tobacco epidemic. Although significant progress has been made, the sheer enormity and scope of the global problem put it on track to take a billion lives this century. Curbing the epidemic will require maximizing the impact of proven tools as well as the development of new, breakthrough methods to help interrupt the spread of nicotine addiction and reduce the downstream morbidity. Members of the Tobacco Action Committee of the American Thoracic Society queried bibliographic databases, including Medline, Embase, and the Cochrane Collaborative, to identify primary sources and reviews relevant to the epidemic. Exploded search terms were used to identify evidence, including tobacco, addiction, smoking, cigarettes, nicotine, and smoking cessation. Evidence was consolidated into three thematic areas: (1) determinants of risk, (2) maternal-fetal exposure, and (3) current tobacco users. Expert panel consensus regarding current gaps in understanding and recommendations for future research priorities was generated through iterative discussion. Although much has been accomplished, significant gaps in understanding remain. Implementation often lags well behind insight. This report identifies a number of investigative opportunities for significantly reducing the toll of tobacco use, including: (1) the need for novel, nonlinear models of population-based disease control; (2) refinement of "real-world" models of clinical intervention in trial design; and (3) understanding of mechanisms by which intrauterine smoke exposure may lead to persistent, tobacco-related chronic disease. In the coming era of tobacco research, pooled talent from multiple disciplines will be required to further illuminate the complex social, environmental and biological codeterminants of tobacco dependence.

  17. Hypnosis, suggestion, and suggestibility: an integrative model.

    Science.gov (United States)

    Lynn, Steven Jay; Laurence, Jean-Roch; Kirsch, Irving

    2015-01-01

    This article elucidates an integrative model of hypnosis that integrates social, cultural, cognitive, and neurophysiological variables at play both in and out of hypnosis and considers their dynamic interaction as determinants of the multifaceted experience of hypnosis. The roles of these variables are examined in the induction and suggestion stages of hypnosis, including how they are related to the experience of involuntariness, one of the hallmarks of hypnosis. It is suggested that studies of the modification of hypnotic suggestibility; cognitive flexibility; response sets and expectancies; the default-mode network; and the search for the neurophysiological correlates of hypnosis, more broadly, in conjunction with research on social psychological variables, hold much promise to further understanding of hypnosis.

  18. Current Situation and Suggestions for Development of Recycling Agriculture in Lingwu Municipality%灵武市循环农业发展现状及建议

    Institute of Scientific and Technical Information of China (English)

    张仲军; 杨金贵; 俞宏彪

    2015-01-01

    The combination of agriculture with animal husbandry as well as planting with livestock raising is a kind of recy-cling agriculture. Based on an investigation on the current situation of the combination of agriculture with animal husbandry as well as planting with livestock raising in Lingwu Municipality, an exploration is made on the development of recycling a-griculture, organic agriculture and the new ways for supporting animal husbandry with agriculture and promoting agriculture with animal husbandry.%农牧种养结合是循环农业的一种形式,通过对灵武市农牧种养结合现状调研,探索发展循环农业、有机农业、以"农养牧,以牧促农"的新路子.

  19. 耕地保护生态补偿现状及政策建议%Current Situation and Policy Suggestion of Ecological Compensation for Cultivated Land Protection

    Institute of Scientific and Technical Information of China (English)

    李林; 李海燕

    2015-01-01

    On the basis of exploration of the present situation of cultivated land protection of ecological compensation in China,the necessity to establish the ecological compensation of cultivated land protection was analyzed,and relevant policy suggestions to perfect the ecological compensation for farmland protection in China were finally put forward.%在剖析我国耕地保护生态补偿现状的基础上,分析建立耕地保护生态补偿的必要性,最后提出完善我国耕地保护生态补偿的相关政策建议。

  20. Current Status of Food Safety System in China and Suggestions%我国食品安全体系现状及建议

    Institute of Scientific and Technical Information of China (English)

    段云

    2011-01-01

    从食品安全战略、食品安全组织、食品安全法律法规、我国食品安全领域存在的问题和建议等方面综述我国食品安全体系。%Food safety plays important role in our life.Recently,there occur several incidents in food safety,which was noticed by our government.This paper mainly reviewed the food safety strategies,organizations,laws and regulations,problems and suggestions for the problems.

  1. How Do We Understand Children’s Restlessness? A Critique of the Biopsychosocial Model and ADHD as the Dominating Perspective in Current Understanding and Treatment

    Directory of Open Access Journals (Sweden)

    Anna Helle-Valle

    2014-03-01

    Full Text Available How is children’s restlessness understood and handled by surrounding adults? Two approaches are outlined in this article: one is the biomedical and later the biopsychosocial model, the other is a tradition that can be traced back to Foucault’s concept of historical ontology. The biopsychosocial model and ADHD is currently the dominating perspective when it comes to describing, understanding and treating restlessness in children. In this tradition, a focus on pathology and biology places the root of the problem within the child and positions the surrounding adults as neutral observers and helpers. By contrast, historical ontology opens up to questions about the neutrality and validity of a biopsychosocial approach by pointing to our active role as subjects in creating ideas of truth about children, in judging their behaviour and in “helping” them. Rather than claiming that one approach is better than the other, it can be useful to regard the two traditions as providing different levels of analysis and be aware of the possibilities and limitations pertaining to these.

  2. 中国天然橡胶产业现状及其发展建议%Current Situation of Chinese Natural Rubber Industry and Development Suggestions

    Institute of Scientific and Technical Information of China (English)

    祁栋灵; 王秀全; 张志扬; 黄月球

    2013-01-01

    This paper analyzes general situation of development in Chinese natural rubber industry, the industrial status and role of Chinese natural rubber industry, as well as establish production impetus of Chinese rubber science & technology to rubber production, and putting forward some suggestions on how to improve Chinese natural rubber industry.%从我国天然橡胶产业发展概况、产业的地位和作用,以及我国橡胶科技对植胶生产的推动作用等方面对中国天然橡胶产业发展现状进行了综述,并提出了促进我国天然橡胶产业发展提升的建议.

  3. Current situation and suggestions for pressure ulcer management in China%我国压疮管理现状与建议

    Institute of Scientific and Technical Information of China (English)

    张洪君; 卢㛃; 刘金莲

    2014-01-01

    Pressure ulcer is a common and important complication in clinical nursing. Its mechanism is complicated. Pressure ulcer widely exists in different departments of hospital and would greatly inlfuence patients. This paper summarized and analyzed the current situation of pressure ulcer management in China. The ideas and methods of pressure ulcer management from abroad had been applied in some medical institutions in China, and were modiifed in order to ift themselves. But due to the diversity of our medical institutions, we still need to formulate a uniifed nursing standard to improve the prevention and treatment management of pressure ulcer in our country.%压疮是临床护理工作中常见的重要并发症,其发生机制复杂,广泛存在于各科室,给患者带来较大影响。本文通过对目前我国压疮管理现状的分析发现,国际压疮护理管理理念和方法已经在我国部分医疗机构得到改进和应用,逐步形成适合我国的压疮防治规范。但是,由于我国各地医疗机构水平参差不齐,为提高全国整体压疮预防与治疗管理水平,还须制订统一的全国压疮护理标准。

  4. Promotion of sexual education by nurses in Macau-current state and suggestions%澳门护士推行性教育现状与建议

    Institute of Scientific and Technical Information of China (English)

    余惠莺; 黄翠萍; 李雪屏

    2015-01-01

    In the recent decade,the Macau Government,community associations and schools have been making concerted efforts to initiate sexual education.Nursing professionals in Macau,being the largest population of frontline health care providers,play an indispensable role in promoting adolescents’sexual health.Nurses in Macau have been promoting sexual education in three aspects,namely (1)nursing students initiate sexual education pro-jects under supervisors’guidance,(2)nurses in schools promote sexual health to school students on a regular ba-sis,(3)apart from launching relevant promotion activities in communities,professional associations of nurses also provide consultative services on physiological and sexual knowledge to adolescents in collaboration with the Govern-ment.Moreover,by organizing academic symposia,the associations initiate discussions on relevant topics and offer suggestions to the Government to consummate the relevant policies.In terms of the role in sexual health promotion, in addition to offering disease assessment,examination and nursing care,and arranging sexual health promotion ac-tivities in communities and schools,nursing professionals are suggested to also take up the responsibilities from the leadership aspect by monitoring and enhancing the quality and safety of the relevant services.Furthermore,from the research aspect,nursing professionals may initiate relevant researches and capitalize on the research findings to ele-vate service quality.%近十年,澳门政府、民间机构、学校共同合作开展性教育,澳门的护理人员作为前线健康服务提供者中最大的群体,在青少年的性健康上担当着不可或缺的角色。澳门护士从三个层次推行性教育,一是澳门护士学生在导师带领下开展性教育项目;二是澳门学校护士在学校定期推广性健康,对学生进行性教育;三是护士专业团体除到小区进行有关推广外,还会与政府合作为青少年提供生

  5. Current situation and Suggestions About Overseas Investment of Suzhou enterprises%苏州企业境外投资现状及发展建议

    Institute of Scientific and Technical Information of China (English)

    姚晴霞

    2013-01-01

    Suzhou in attracting foreign investment has made remarkable achievements,but with respect to overseas investment,it is still in the initial stage.Suzhou enterprises’overseas investment has dominant force private enterprises,investment diversification and expanding . The main difficulty faced by overseas investment is not familiar with the investment policy and legal environment ,government support policies unsound,the lack of international management talent and financing difficulties,and finally put forward suggestion.%苏州在吸引国际资本方面取得了令人瞩目的成绩,但苏州的境外投资相对于利用外资来说,还处于起步阶段。苏州企业境外投资呈现民营企业是投资主导力量、境外投资方式多元化和投资规模不断扩大的特点。企业开展境外投资面临的困难和问题是企业对境外投资政策和法律环境的不熟悉、政府境外投资支持政策和服务体系不健全、国际化经营人才缺乏和融资难四个方面,最后针对性地提出促进苏州企业境外投资的建议。

  6. 我国玉米品种权保护现状及建设%Current Situation and Suggestions on the Protection of Maize Variety Rights in China

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    In order to strengthen the protection of maize new variety rightsm ,standardize seed market ,ensure food security ,the protection present situation of maize variety rights in China was discussed ,the existing prob-lems were analysed such as the too long period of the review ,the delay of economic transformation of author-ized varieties ,the seriousness of infringing upon variety rights and the difficulty of safeguarding the variety rights ,the improvement suggestions of maize variety rights in China were put forward .The protection strategy of variety rightsm were proposed ,including building up the system of approv combining between approbation and protection ,standardizing the trading platform of variety rightsm ,strengthen the peralties for infringement , encouraging the cooperation between school and enterprise ,speeding up the pace of achievement transformation%  为了加强玉米新品种权的保护,规范种子市场,确保粮食安全,阐述了我国玉米品种权保护的现状,分析了玉米品种权存在审查周期过长、授权品种经济转化滞后、侵权严重和维权艰难等问题,提出了应建立品种审定和保护相结合的体制、规范的品种权交易平台、加大对侵权的惩处力度、鼓励院企业作加速成果转化步伐等品种权保护策略。

  7. Current understanding of the processes underlying the triggering of and energy loss associated with type I ELMs

    CERN Document Server

    Kirk, A; Dunne, M; Huijsmans, G; Pamela, S; Becoulet, M; Harrison, J R; Hillesheim, J; Roach, C; Saarelma, S

    2013-01-01

    The type I ELMy H-mode is the baseline operating scenario for ITER. While it is known that the type I ELM ultimately results from the peeling-ballooning instability, there is growing experimental evidence that a mode grows up before the ELM crash that may modify the edge plasma, which then leads to the ELM event due to the peeling-ballooning mode. The triggered mode results in the release of a large number of particles and energy from the core plasma but the precise mechanism by which these losses occur is still not fully understood and hence makes predictions for future devices uncertain. Our current understanding of the processes that trigger type I ELMs and the size of the resultant energy loss are reviewed and compared to experimental data and ideas for further development are discussed.

  8. Attitudes to Suggestions

    Institute of Scientific and Technical Information of China (English)

    PETER; JOHNSON

    2007-01-01

    As an Australian expat teaching English in China for over four years, I often encourage my students to not only learn the English language but also try to understand Western culture. This includes the fact that Westerners frequently initiate proactive suggestions on any aspects of soci-

  9. Microplastics in freshwater and terrestrial environments: Evaluating the current understanding to identify the knowledge gaps and future research priorities.

    Science.gov (United States)

    Horton, Alice A; Walton, Alexander; Spurgeon, David J; Lahive, Elma; Svendsen, Claus

    2017-05-15

    Plastic debris is an environmentally persistent and complex contaminant of increasing concern. Understanding the sources, abundance and composition of microplastics present in the environment is a huge challenge due to the fact that hundreds of millions of tonnes of plastic material is manufactured for societal use annually, some of which is released to the environment. The majority of microplastics research to date has focussed on the marine environment. Although freshwater and terrestrial environments are recognised as origins and transport pathways of plastics to the oceans, there is still a comparative lack of knowledge about these environmental compartments. It is highly likely that microplastics will accumulate within continental environments, especially in areas of high anthropogenic influence such as agricultural or urban areas. This review critically evaluates the current literature on the presence, behaviour and fate of microplastics in freshwater and terrestrial environments and, where appropriate, also draws on relevant studies from other fields including nanotechnology, agriculture and waste management. Furthermore, we evaluate the relevant biological and chemical information from the substantial body of marine microplastic literature, determining the applicability and comparability of this data to freshwater and terrestrial systems. With the evidence presented, the authors have set out the current state of the knowledge, and identified the key gaps. These include the volume and composition of microplastics entering the environment, behaviour and fate of microplastics under a variety of environmental conditions and how characteristics of microplastics influence their toxicity. Given the technical challenges surrounding microplastics research, it is especially important that future studies develop standardised techniques to allow for comparability of data. The identification of these research needs will help inform the design of future studies, to

  10. A short review of our current understanding of the development of ring faults during collapse caldera formation

    Directory of Open Access Journals (Sweden)

    Adelina eGeyer

    2014-09-01

    Full Text Available The term collapse caldera refers to those volcanic depressions resulting from the sinking of the chamber roof due to the rapid withdrawal of magma during the course of an eruption. During the last three decades, collapse caldera dynamics has been the focus of attention of numerous, theoretical, numerical and experimental studies. Nonetheless, even if there is a tendency to go for a general and comprehensive caldera dynamics model, some key aspects remain unclear, controversial or completely unsolved. This is the case of ring fault nucleation points and propagation and dip direction. Since direct information on calderas’ deeper structure comes mainly from partially eroded calderas or few witnessed collapses, ring faults layout at depth remains still uncertain. This has generated a strong debate over the detailed internal fault and fracture configuration of a caldera collapse and, in more detail, how ring faults initiate and propagate. We offer here a very short description of the main results obtained by those analogue and theoretical/mathematical models applied to the study of collapse caldera formation. We place special attention on those observations related to the nucleation and propagation of the collapse-controlling ring faults. This summary is relevant to understand the current state-of-the-art of this topic and it should be taken under consideration in future works dealing with collapse caldera dynamics.

  11. Toward Understanding the Role of Aryl Hydrocarbon Receptor in the Immune System: Current Progress and Future Trends

    Directory of Open Access Journals (Sweden)

    Hamza Hanieh

    2014-01-01

    Full Text Available The immune system is regulated by distinct signaling pathways that control the development and function of the immune cells. Accumulating evidence suggest that ligation of aryl hydrocarbon receptor (Ahr, an environmentally responsive transcription factor, results in multiple cross talks that are capable of modulating these pathways and their downstream responsive genes. Most of the immune cells respond to such modulation, and many inflammatory response-related genes contain multiple xenobiotic-responsive elements (XREs boxes upstream. Active research efforts have investigated the physiological role of Ahr in inflammation and autoimmunity using different animal models. Recently formed paradigm has shown that activation of Ahr by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or 3,3′-diindolylmethane (DIM prompts the differentiation of CD4+Foxp3+ regulatory T cells (Tregs and inhibits T helper (Th-17 suggesting that Ahr is an innovative therapeutic strategy for autoimmune inflammation. These promising findings generate a basis for future clinical practices in humans. This review addresses the current knowledge on the role of Ahr in different immune cell compartments, with a particular focus on inflammation and autoimmunity.

  12. Current Understanding of HSP90 as a Novel Therapeutic Target: An Emerging Approach for the Treatment of Cancer.

    Science.gov (United States)

    Haque, Absarul; Alam, Qamre; Alam, Mohammad Zubair; Azhar, Esam I; Sait, Khalid Hussain Wali; Anfinan, Nisrin; Mushtaq, Gohar; Kamal, Mohammad Amjad; Rasool, Mahmood

    2016-01-01

    Heat Shock Protein 90 (HSP90) is a ubiquitous molecular chaperone that is considered to be the most abundantly expressed protein in various human cancers such as breast, lung, colon, prostate, leukemia and skin. The master regulator, HSP90 plays a pivotal role in the conformational stabilization, maturation and activity of its various labile oncogenic client proteins such as p53, ErbB2, Bcr-Abl, Akt, Her-2, Cdk4, Cdk6, Raf-1 and v-Src in altered cells. Hence, making a guaranteed attempt to inhibit such a master regulator for cancer therapy appears to be a potential approach for combinatorial inhibition of numerous oncogenic signaling pathways simultaneously. Considerable efforts are being under way to develop novel molecular targets and its inhibitors that may block key signaling pathways involved in the process of tumorigenesis and metastasis. In this regards, HSP90 has acquired immense interest as a potent anticancer drug-target due to its key functional link with multiple signaling pathways involved in the process of cell proliferation and cell survival. Notably, geldanamycin and its derivatives (17-AAG, 17-DMAG) have shown quite encouraging results in inhibiting HSP90 function in several cancers and currently almost 17 drug candidates known to be target HSP90 are being under clinical trials either as single agents or combinatorial therapy. Hence, this review is an attempt to get new insight into novel drug target therapy by focusing on recent advances made in understanding HSP90 chaperone structure-function relationships, identification of new HSP90 client proteins and, more importantly, on the advancements of HSP90 targeted therapy based on various existing and emerging classical inhibitors.

  13. Current Understanding on the Role of Standard and Immunoproteasomes in Inflammatory/Immunological Pathways of Multiple Sclerosis

    Directory of Open Access Journals (Sweden)

    Elena Bellavista

    2014-01-01

    Full Text Available The ubiquitin-proteasome system is the major intracellular molecular machinery for protein degradation and maintenance of protein homeostasis in most human cells. As ubiquitin-proteasome system plays a critical role in the regulation of the immune system, it might also influence the development and progression of multiple sclerosis (MS. Both ex vivo analyses and animal models suggest that activity and composition of ubiquitin-proteasome system are altered in MS. Proteasome isoforms endowed of immunosubunits may affect the functionality of different cell types such as CD8+ and CD4+ T cells and B cells as well as neurons during MS development. Furthermore, the study of proteasome-related biomarkers, such as proteasome antibodies and circulating proteasomes, may represent a field of interest in MS. Proteasome inhibitors are already used as treatment for cancer and the recent development of inhibitors selective for immunoproteasome subunits may soon represent novel therapeutic approaches to the different forms of MS. In this review we describe the current knowledge on the potential role of proteasomes in MS and discuss the pro et contra of possible therapies for MS targeting proteasome isoforms.

  14. The emergence of international food safety standards and guidelines: understanding the current landscape through a historical approach.

    Science.gov (United States)

    Ramsingh, Brigit

    2014-07-01

    Following the Second World War, the Food and Agriculture Organization (FAO) and the World Health Organization (WHO) teamed up to construct an International Codex Alimentarius (or 'food code') which emerged in 1963. The Codex Committee on Food Hygiene (CCFH) was charged with the task of developing microbial hygiene standards, although it found itself embroiled in debate with the WHO over the nature these standards should take. The WHO was increasingly relying upon the input of biometricians and especially the International Commission on Microbial Specifications for Foods (ICMSF) which had developed statistical sampling plans for determining the microbial counts in the final end products. The CCFH, however, was initially more focused on a qualitative approach which looked at the entire food production system and developed codes of practice as well as more descriptive end-product specifications which the WHO argued were 'not scientifically correct'. Drawing upon historical archival material (correspondence and reports) from the WHO and FAO, this article examines this debate over microbial hygiene standards and suggests that there are many lessons from history which could shed light upon current debates and efforts in international food safety management systems and approaches.

  15. Food webs of the Delta, Suisun Bay and Suisun Marsh: an update on current understanding and possibilities for management

    Science.gov (United States)

    Brown, Larry R.; Kimmerer, Wim J.; Conrad, Louise; Lesmeister, Sarah; Mueller-Solger, Anke

    2017-01-01

    This paper reviews and highlights recent research findings on foodweb processes since an earlier review by Kimmerer et al. (2008). We conduct this review within a conceptual framework of the Delta-Suisun food web, which includes both temporal and spatial components. The temporal component is based on knowledge that the landscape has changed markedly from historical conditions. The spatial component of our framework acknowledges that the food web is not spatially static; it varies regionally and across habitat types within regions. The review highlights the idea of a changing baseline with respect to foodweb function. New research also indicates that interactions between habitat-specific food webs vary across the current landscape. For example, based on early work in the South Delta, the food web associated with submerged aquatic vegetation was thought to provide little support to species of concern; however, data from other regions of the estuary suggest that this conceptual model may not apply across the entire region. Habitat restoration has been proposed as a method of re-establishing historic foodweb processes to support species of concern. Benefits are likely for species that directly access such restored habitats, but are less clear for pelagic species. Several topics require attention to further improve the knowledge of food webs needed to support effective management, including: 1) synthesis of factors responsible for low pelagic biomass; 2) monitoring and research on effects of harmful algal blooms; 3) broadening the scope of long-term monitoring; 4) determining benefits of tidal wetland restoration to species of concern, including evaluations of interactions of habitat-specific food webs; and 5) interdisciplinary analysis and synthesis. The only certainty is that food webs will continue to change in response to the changes in the physical environment and new species invasions.

  16. International Veterinary Epilepsy Task Force's current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs

    DEFF Research Database (Denmark)

    Hülsmeyer, Velia-Isabel; Fischer, Andrea; Mandigers, Paul J. J.;

    2015-01-01

    Canine idiopathic epilepsy is a common neurological disease affecting both purebred and crossbred dogs. Various breed-specific cohort, epidemiological and genetic studies have been conducted to date, which all improved our knowledge and general understanding of canine idiopathic epilepsy, and in ...

  17. How Secondary History Teachers Use and Think about Museums: Current Practices and Untapped Promise for Promoting Historical Understanding

    Science.gov (United States)

    Marcus, Alan S.; Levine, Thomas H.; Grenier, Robin S.

    2012-01-01

    Museums have great potential to help secondary students develop a deep understanding of the past; however, we know little about what history teachers actually do or want to accomplish when they utilize museums. In this study, the authors draw on questionnaire and interview data from 94 secondary history teachers in Connecticut in an effort to…

  18. 广西河湖水域岸线管理现状分析及建议%Current status analysis and suggestions for administration of river-lake shoreline and water area in Guangxi

    Institute of Scientific and Technical Information of China (English)

    王晓妮

    2013-01-01

    An introduction was made on the current status of river-lake shoreline and water area administration in Guangxi. The author analyzed the major problems and put forward suggestions for strengthening administration.%  介绍了广西河湖水域岸线管理现状,分析现阶段管理中存在的主要问题,并提出加强河湖水域及岸线管理的建议措施。

  19. Interactive effects of air pollution and climate change on forest ecosystems in the United States: current understanding and future scenarios

    Science.gov (United States)

    Andrzej Bytnerowicz; Mark Fenn; Steven McNulty; Fengming Yuan; Afshin Pourmokhtarian; Charles Driscoll; Tom Meixner

    2013-01-01

    A review of the current status of air pollution and climate change (CC) in the United States from a perspective of their impacts on forest ecosystems is provided. Ambient ozone (O3) and nitrogen (N) deposition have important and widespread ecological impacts in U.S. forests. Effects of sulphurous (S) air pollutants and other trace pollutants have...

  20. Using Freire's Participatory Educational Method to Understand the Experience of Living With Chronic Illness in the Current Age of Globalization.

    Science.gov (United States)

    Camargo Plazas, Maria del Pilar; Cameron, Brenda L

    2015-06-01

    Many approaches and efforts have been used to better understand chronic diseases worldwide. Yet, little is known about the meaning of living with chronic illness under the pressures of globalization and neoliberal ideologies. Through Freire's participatory educational method, this article presents an innovative approach to understanding the multiple dimensions of living with chronic illness. In this way, we hope to use an innovative approach to address the impact of globalization on the daily life of chronically ill people and thus expand to the body of knowledge on nursing. This article uses Freire's participatory educational method to understand the multiple dimensions of living with chronic illness. This qualitative study follows an interpretive inquiry approach and uses a critical hermeneutic phenomenological method and critical research methodologies. Five participants were recruited for this participatory educational activity. Data collection methods included digitally recorded semistructured individual interviews and a Freire's participatory educational method session. Data analysis included a thematic analysis. Participants reported lacking adequate access to healthcare services because of insurance policies; a general perception that they were an unwanted burden on the healthcare system; and a general lack of government support, advocacy, and political interest. This research activity assisted participants to gain a new critical perspective about the condition of others with chronic diseases and thus provided an enlightening opportunity to learn about the illnesses and experiences of others and to realize that others experienced the same oppression from the healthcare system. Participants became agents of change within their own families and communities. Chronic diseases cause many economic and social consequences in their victims. These findings urge us to move from merely acknowledging the difficulties of people who live with chronic illness in an age of

  1. The current state of Contract Law in Australia and why it is important for rural managers to understand it

    OpenAIRE

    Smith, Tony

    2011-01-01

    Farmers are business managers and as such they must understand the law or they are likely to fall foul of it. This especially applies to contract law, with which they deal constantly. Contract law is made up of the common law – as the courts have decided it – and statute law- as the state and federal parliaments have enacted statutes which modify the common law. The most important and most recent of the latter is the new Australian Consumer Law.

  2. Calcium window currents, periodic forcing, and chaos: Understanding single neuron response with a discontinuous one-dimensional map

    Science.gov (United States)

    Laudanski, J.; Sumner, C.; Coombes, S.

    2010-07-01

    Thalamocortical (TC) neurones are known to express the low-voltage activated, inactivating Ca2+ current IT . The triggering of this current underlies the generation of low threshold Ca2+ potentials that may evoke single or bursts of action potentials. Moreover, this current can contribute to an intrinsic slow (dynamics for the gating variables in the model of IT . This model can be analyzed in closed form and is shown to support an unstable set of periodic orbits. Trajectories are repelled from these organizing centers until they reach the threshold for firing. By determining the condition for a grazing bifurcation (at the border between a spiking and nonspiking event) we show how knowledge of the unstable periodic orbits (existence and stability) can be combined with the grazing condition to determine an effective one-dimensional map that captures the essentials of the chaotic behavior. This map is discontinuous and has strong similarities with the universal limit mapping in grazing bifurcations derived in the context of impacting mechanical systems [A. B. Nordmark, Phys. Rev. E 55, 266 (1997)10.1103/PhysRevE.55.266].

  3. Current concepts on burn wound conversion-A review of recent advances in understanding the secondary progressions of burns.

    Science.gov (United States)

    Salibian, Ara A; Rosario, Angelica Tan Del; Severo, Lucio De Almeida Moura; Nguyen, Long; Banyard, Derek A; Toranto, Jason D; Evans, Gregory R D; Widgerow, Alan D

    2016-08-01

    Burn wound conversion describes the process by which superficial partial thickness burns convert into deeper burns necessitating surgical intervention. Fully understanding and thus controlling this phenomenon continues to defy burn surgeons. However, potentially guiding burn wound progression so as to obviate the need for surgery while still bringing about healing with limited scarring is the major unmet challenge. Comprehending the pathophysiologic background contributing to deeper progression of these burns is an essential prerequisite to planning any intervention. In this study, a review of articles examining burn wound progression over the last five years was conducted to analyze trends in recent burn progression research, determine changes in understanding of the pathogenesis of burn conversion, and subsequently examine the direction for future research in developing therapies. The majority of recent research focuses on applying therapies from other disease processes to common underlying pathogenic mechanisms in burn conversion. While ischemia, inflammation, and free oxygen radicals continue to demonstrate a critical role in secondary necrosis, novel mechanisms such as autophagy have also been shown to contribute affect significantly burn progression significantly. Further research will have to determine whether multiple mechanisms should be targeted when developing clinical therapies.

  4. Building a shared understanding of the skills and competences in order to respond to the current global technical challenges

    DEFF Research Database (Denmark)

    Friesel, Anna; Ward, Anthony; Welzer, Tatjana

    2014-01-01

    A pan-European team, including the representatives from 45 European universities, is working on an EU supported project to firstly explore and then provide models for ways in which Higher Education Institutions of Europe in the Electrical and Information Engineering disciplines can respond...... to current challenges. This paper presents the objectives and actual results of the EU supported project which runs from October 2012 to November 2015, named SALEIE - Strategic Alignment of Electrical and Information Engineering in European Higher Education Institutions. We describe in this paper...

  5. Cannabinoids therapeutic use: what is our current understanding following the introduction of THC, THC:CBD oromucosal spray and others?

    Science.gov (United States)

    Maccarrone, Mauro; Maldonado, Rafael; Casas, Miguel; Henze, Thomas; Centonze, Diego

    2017-04-01

    The complexity of the endocannabinoid (eCB) system is becoming better understood and new drivers of eCB signaling are emerging. Modulation of the activities of the eCB system can be therapeutic in a number of diseases. Research into the eCB system has been paralleled by the development of agents that interact with cannabinoid receptors. In this regard it should be remembered that herbal cannabis contains a myriad of active ingredients, and the individual cannabinoids have quite distinct biological activities requiring independent studies. Areas covered: This article reviews the most important current data involving the eCB system in relation to human diseases, to reflect the present (based mainly on the most used prescription cannabinoid medicine, THC/CBD oromucosal spray) and potential future uses of cannabinoid-based therapy. Expert commentary: From the different therapeutic possibilities, THC/CBD oromucosal spray has been in clinical use for approximately five years in numerous countries world-wide for the management of multiple sclerosis (MS)-related moderate to severe resistant spasticity. Clinical trials have confirmed its efficacy and tolerability. Other diseases in which different cannabinoids are currently being investigated include various pain states, Alzheimer's disease, Parkinson's disease, Huntington's disease and epilepsy. The continued characterization of individual cannabinoids in different diseases remains important.

  6. Simultaneous visualization of oxygen partial pressure, current density, and water droplets in serpentine fuel cell during power generation for understanding reaction distributions

    Science.gov (United States)

    Takanohashi, Kazuhiro; Suga, Takeo; Uchida, Makoto; Ueda, Toshihide; Nagumo, Yuzo; Inukai, Junji; Nishide, Hiroyuki; Watanabe, Masahiro

    2017-03-01

    Understanding the reaction distributions inside a polymer electrolyte fuel cell (PEFC) is essential for the higher performance and durability. We have developed a new see-through cell and visualized the distributions of oxygen partial pressure and current density inside a running PEFC at the temperature of 40 and 80 °C and the relative humidity of 53%. The oxygen utilization was changed from 0% to 80% by changing the current density. At higher oxygen utilizations, the current density was higher and therefore the water generation. Generated water droplets in the flow channel were also visualized, allowing for the simultaneous visualization of the distribution of the oxygen partial pressure, current density, and water droplets. By combining the observations of all three parameters, the reactions inside a membrane-electrode assembly were discussed.

  7. Biocompatibility of ionic liquids towards protein stability: A comprehensive overview on the current understanding and their implications.

    Science.gov (United States)

    Kumar, Awanish; Bisht, Meena; Venkatesu, Pannuru

    2017-03-01

    Over the past years since the discovery of ionic liquids (ILs), there is an increased demand to consider ILs as novel biocompatible co-solvents for proteins. Due to their tunable physical properties ILs can adjust themselves in any required experimental conditions starting from protein extraction to enzyme catalysis at elevated temperature. In recent years, large numbers of ILs have been synthesized and their effect on protein stability has been illustrated. With the rapid growth in various kinds of ILs, our understanding of protein stability in ILs has substantially increased. It is not necessary that a particular IL that is biocompatible to a protein will behave same for the other. Therefore, it is extremely essential to collect the literature dealing with the direct involvement of ILs in protein folding/unfolding studies under the same roof. This review focuses the tremendous accomplishments achieved in recent years in the field of protein stability in ILs. We hope that this would also help to set a stage where we can identify, explore and compare the mechanistic behavior of protein folding/unfolding in ILs. This review will surely bring a new boost in protein folding studies from the chemical biology perspective.

  8. Guar gum and similar soluble fibers in the regulation of cholesterol metabolism: Current understandings and future research priorities

    Directory of Open Access Journals (Sweden)

    Todd C Rideout

    2008-10-01

    Full Text Available Todd C Rideout1, Scott V Harding1, Peter JH Jones1, Ming Z Fan21Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada; 2Centre for Nutrition Modeling, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, CanadaAbstract: The hypocholesterolemic effects associated with soluble fiber consumption are clear from animal model and human clinical investigations. Moreover, the modulation of whole-body cholesterol metabolism in response to dietary fiber consumption, including intestinal cholesterol absorption and fecal sterol and bile acid loss, has been the subject of many published reports. However, our understanding of how dietary fibers regulate molecular events at the gene/protein level and alter cellular cholesterol metabolism is limited. The modern emphasis on molecular nutrition and rapid progress in ‘high-dimensional’ biological techniques will permit further explorations of the role of genetic polymorphisms in determining the variable interindividual responses to soluble fibers. Furthermore, with traditional molecular biology tools and the application of ‘omic’ technology, specific insight into how fibers modulate the expression of genes and proteins that regulate intestinal cholesterol absorption and alter hepatic sterol balance will be gained. Detailed knowledge of the molecular mechanisms by which soluble fibers reduce plasma cholesterol concentrations is paramount to developing novel fiber-based “cocktails” that target specific metabolic pathways to gain maximal cholesterol reductions.Keywords: dietary fiber, cholesterol, bile acids, gene, protein

  9. Current Gaps in the Understanding of the Subcellular Distribution of Exogenous and Endogenous Protein TorsinA.

    Science.gov (United States)

    Harata, N Charles

    2014-01-01

    An in-frame deletion leading to the loss of a single glutamic acid residue in the protein torsinA (ΔE-torsinA) results in an inherited movement disorder, DYT1 dystonia. This autosomal dominant disease affects the function of the brain without causing neurodegeneration, by a mechanism that remains unknown. We evaluated the literature regarding the subcellular localization of torsinA. Efforts to elucidate the pathophysiological basis of DYT1 dystonia have relied partly on examining the subcellular distribution of the wild-type and mutated proteins. A typical approach is to introduce the human torsinA gene (TOR1A) into host cells and overexpress the protein therein. In both neurons and non-neuronal cells, exogenous wild-type torsinA introduced in this manner has been found to localize mainly to the endoplasmic reticulum, whereas exogenous ΔE-torsinA is predominantly in the nuclear envelope or cytoplasmic inclusions. Although these outcomes are relatively consistent, findings for the localization of endogenous torsinA have been variable, leaving its physiological distribution a matter of debate. As patients' cells do not overexpress torsinA proteins, it is important to understand why the reported distributions of the endogenous proteins are inconsistent. We propose that careful optimization of experimental methods will be critical in addressing the causes of the differences among the distributions of endogenous (non-overexpressed) vs. exogenously introduced (overexpressed) proteins.

  10. Airborne, Balloon-borne and ground network measurements of aerosol BC over Indian region: Current understanding and possible implications

    Science.gov (United States)

    Nair, Vijayakumar S.; Krishna Moorthy, K.; Babu, Suresh, S.; Manoj, M. R.; Gogoi, Mukunda

    2012-07-01

    Though the role of BC aerosols in direct and indirect aerosol climate forcing is now well accepted and being extensively investigated, there is a large knowledge gap on its vertical distribution. Large amounts of BC, if present above and within the clouds, could significantly modify the atmospheric heating due to aerosol absorption. In the back drop of some of the recent measurements of strong BC layers in the middle and upper troposphere and even in the stratosphere, the knowledge of vertical distribution of BC becomes all the more relevant, especially over the tropics, with significant solar heating, cloud cover and BC hotspots. With a view to addressing this issue from comprehensive measurements over Indian region, extensive measurements using aircrafts, balloons, and a large network of ground-based observatories have been made as a part of the Regional Aerosol Warming Experiment (RAWEX). These measurements were examined in the light of simulations made using the regional climate model (RegCM of ICTP) to understand the ability and biases of climate models. While the aircraft measurements revealed presence of strong BC layers above the atmospheric boundary layer, within which the BC concentration often exceeded those near the surface. These layers were more elevated and strong along the eastern coast and over Bay of Bengal, rather than on the west. The RegCM simulations were found to underestimate the BC concentrations, especially during the daytime probably owing to inadequate representation of ABL dynamics. The details would be presented and implications would be discussed

  11. Current Understanding of Lifestyle and Environmental Factors and Risk of Non-Hodgkin Lymphoma: An Epidemiological Update

    Directory of Open Access Journals (Sweden)

    Bryan A. Bassig

    2012-01-01

    Full Text Available The incidence rates of non-Hodgkin lymphoma (NHL have steadily increased over the last several decades in the United States, and the temporal trends in incidence can only be partially explained by the HIV epidemic. In 1992, an international workshop sponsored by the United States National Cancer Institute concluded that there was an “emerging epidemic” of NHL and emphasized the need to investigate the factors responsible for the increasing incidence of this disease. Over the past two decades, numerous epidemiological studies have examined the risk factors for NHL, particularly for putative environmental and lifestyle risk factors, and international consortia have been established in order to investigate rare exposures and NHL subtype-specific associations. While few consistent risk factors for NHL aside from immunosuppression and certain infectious agents have emerged, suggestive associations with several lifestyle and environmental factors have been reported in epidemiologic studies. Further, increasing evidence has suggested that the effects of these and other exposures may be limited to or stronger for particular NHL subtypes. This paper examines the progress that has been made over the last twenty years in elucidating the etiology of NHL, with a primary emphasis on lifestyle factors and environmental exposures.

  12. Understanding the current anatomical competence landscape: Comparing perceptions of program directors, residents, and fourth-year medical students.

    Science.gov (United States)

    Fillmore, Erin P; Brokaw, James J; Kochhar, Komal; Nalin, Peter M

    2016-07-08

    A mixed methods survey of fourth-year medical students, resident physicians, and residency program directors at the Indiana University School of Medicine gathered perceptions of anatomical competence-defined as the anatomical education necessary for effective clinical practice. The survey items explored numerous aspects of anatomical competence, including the most effective modes of instruction, perceptions of readiness for clinical practice, and specific suggestions for improving anatomical education during medical school and residency. The response rate was 46% for fourth-year medical students, 47% for residents (as graduates from 137 medical schools), and 71% for program directors. A majority of students and residents reported that their course in Gross Anatomy prepared them well for clinical practice; that cadaveric dissection was important in the early development of their anatomical competence; and that placing a greater emphasis on clinical relevance in medical school would have improved their anatomical competence even further. However, in terms of anatomical preparedness upon entering residency, the program directors rated their residents less prepared than the residents rated themselves. All three groups agreed that there is need for additional opportunities for anatomical educational during medical school and residency. Suggestions for improving anatomical education included the following: providing more opportunities for cadaveric dissection during medical school and residency; more consistent teaching of anatomy for clinical practice; more workshops that review anatomy; and better integration of anatomy with the teaching of other subjects during medical school. Anat Sci Educ 9: 307-318. © 2015 American Association of Anatomists.

  13. Current Understanding of Cu-Exchanged Chabazite Molecular Sieves for Use as Commercial Diesel Engine DeNOx Catalysts

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Feng; Kwak, Ja Hun; Szanyi, Janos; Peden, Charles HF

    2013-11-03

    Selective catalytic reduction (SCR) of NOx with ammonia using metal-exchanged molecular sieves with a chabazite (CHA) structure has recently been commercialized on diesel vehicles. One of the commercialized catalysts, i.e., Cu-SSZ-13, has received much attention for both practical and fundamental studies. For the latter, the particularly well-defined structure of this zeolite is allowing long-standing issues of the catalytically active site for SCR in metal-exchanged zeolites to be addressed. In this review, recent progress is summarized with a focus on two areas. First, the technical significance of Cu-SSZ-13 as compared to other Cu-ion exchanged zeolites (e.g., Cu-ZSM-5 and Cu-beta) is highlighted. Specifically, the much enhanced hydrothermal stability for Cu-SSZ-13 compared to other zeolite catalysts is addressed via performance measurements and catalyst characterization using several techniques. The enhanced stability of Cu-SSZ-13 is rationalized in terms of the unique small pore structure of this zeolite catalyst. Second, the fundamentals of the catalytically active center; i.e., the chemical nature and locations within the SSZ-13 framework are presented with an emphasis on understanding structure-function relationships. For the SCR reaction, traditional kinetic studies are complicated by intra-particle diffusion limitations. However, a major side reaction, nonselective ammonia oxidation by oxygen, does not suffer from mass-transfer limitations at relatively low temperatures due to significantly lower reaction rates. This allows structure-function relationships that are rather well understood in terms of Cu ion locations and redox properties. Finally, some aspects of the SCR reaction mechanism are addressed on the basis of in-situ spectroscopic studies.

  14. Analytical approaches to support current understanding of exposure, uptake and distributions of engineered nanoparticles by aquatic and terrestrial organisms.

    Science.gov (United States)

    Schultz, Carolin; Powell, Kate; Crossley, Alison; Jurkschat, Kerstin; Kille, Peter; Morgan, A John; Read, Daniel; Tyne, William; Lahive, Elma; Svendsen, Claus; Spurgeon, David J

    2015-03-01

    Initiatives to support the sustainable development of the nanotechnology sector have led to rapid growth in research on the environmental fate, hazards and risk of engineered nanoparticles (ENP). As the field has matured over the last 10 years, a detailed picture of the best methods to track potential forms of exposure, their uptake routes and best methods to identify and track internal fate and distributions following assimilation into organisms has begun to emerge. Here we summarise the current state of the field, focussing particularly on metal and metal oxide ENPs. Studies to date have shown that ENPs undergo a range of physical and chemical transformations in the environment to the extent that exposures to pristine well dispersed materials will occur only rarely in nature. Methods to track assimilation and internal distributions must, therefore, be capable of detecting these modified forms. The uptake mechanisms involved in ENP assimilation may include a range of trans-cellular trafficking and distribution pathways, which can be followed by passage to intracellular compartments. To trace toxicokinetics and distributions, analytical and imaging approaches are available to determine rates, states and forms. When used hierarchically, these tools can map ENP distributions to specific target organs, cell types and organelles, such as endosomes, caveolae and lysosomes and assess speciation states. The first decade of ENP ecotoxicology research, thus, points to an emerging paradigm where exposure is to transformed materials transported into tissues and cells via passive and active pathways within which they can be assimilated and therein identified using a tiered analytical and imaging approach.

  15. Cerebellar Transcranial Direct Current Stimulation (ctDCS): A Novel Approach to Understanding Cerebellar Function in Health and Disease.

    Science.gov (United States)

    Grimaldi, Giuliana; Argyropoulos, Georgios P; Bastian, Amy; Cortes, Mar; Davis, Nicholas J; Edwards, Dylan J; Ferrucci, Roberta; Fregni, Felipe; Galea, Joseph M; Hamada, Masahi; Manto, Mario; Miall, R Chris; Morales-Quezada, Leon; Pope, Paul A; Priori, Alberto; Rothwell, John; Tomlinson, S Paul; Celnik, Pablo

    2016-02-01

    The cerebellum is critical for both motor and cognitive control. Dysfunction of the cerebellum is a component of multiple neurological disorders. In recent years, interventions have been developed that aim to excite or inhibit the activity and function of the human cerebellum. Transcranial direct current stimulation of the cerebellum (ctDCS) promises to be a powerful tool for the modulation of cerebellar excitability. This technique has gained popularity in recent years as it can be used to investigate human cerebellar function, is easily delivered, is well tolerated, and has not shown serious adverse effects. Importantly, the ability of ctDCS to modify behavior makes it an interesting approach with a potential therapeutic role for neurological patients. Through both electrical and non-electrical effects (vascular, metabolic) ctDCS is thought to modify the activity of the cerebellum and alter the output from cerebellar nuclei. Physiological studies have shown a polarity-specific effect on the modulation of cerebellar-motor cortex connectivity, likely via cerebellar-thalamocortical pathways. Modeling studies that have assessed commonly used electrode montages have shown that the ctDCS-generated electric field reaches the human cerebellum with little diffusion to neighboring structures. The posterior and inferior parts of the cerebellum (i.e., lobules VI-VIII) seem particularly susceptible to modulation by ctDCS. Numerous studies have shown to date that ctDCS can modulate motor learning, and affect cognitive and emotional processes. Importantly, this intervention has a good safety profile; similar to when applied over cerebral areas. Thus, investigations have begun exploring ctDCS as a viable intervention for patients with neurological conditions.

  16. The water vapour continuum in near-infrared windows - Current understanding and prospects for its inclusion in spectroscopic databases

    Science.gov (United States)

    Shine, Keith P.; Campargue, Alain; Mondelain, Didier; McPheat, Robert A.; Ptashnik, Igor V.; Weidmann, Damien

    2016-09-01

    Spectroscopic catalogues, such as GEISA and HITRAN, do not yet include information on the water vapour continuum that pervades visible, infrared and microwave spectral regions. This is partly because, in some spectral regions, there are rather few laboratory measurements in conditions close to those in the Earth's atmosphere; hence understanding of the characteristics of the continuum absorption is still emerging. This is particularly so in the near-infrared and visible, where there has been renewed interest and activity in recent years. In this paper we present a critical review focusing on recent laboratory measurements in two near-infrared window regions (centred on 4700 and 6300 cm-1) and include reference to the window centred on 2600 cm-1 where more measurements have been reported. The rather few available measurements, have used Fourier transform spectroscopy (FTS), cavity ring down spectroscopy, optical-feedback - cavity enhanced laser spectroscopy and, in very narrow regions, calorimetric interferometry. These systems have different advantages and disadvantages. Fourier Transform Spectroscopy can measure the continuum across both these and neighbouring windows; by contrast, the cavity laser techniques are limited to fewer wavenumbers, but have a much higher inherent sensitivity. The available results present a diverse view of the characteristics of continuum absorption, with differences in continuum strength exceeding a factor of 10 in the cores of these windows. In individual windows, the temperature dependence of the water vapour self-continuum differs significantly in the few sets of measurements that allow an analysis. The available data also indicate that the temperature dependence differs significantly between different near-infrared windows. These pioneering measurements provide an impetus for further measurements. Improvements and/or extensions in existing techniques would aid progress to a full characterisation of the continuum - as an example, we

  17. Narcotic analgesic utilization amongst injured workers: using concept mapping to understand current issues from the perspectives of physicians and pharmacists

    Directory of Open Access Journals (Sweden)

    Fortin Claire

    2011-10-01

    , lack of education/support for physicians regarding pain management, unavailability of multidisciplinary team-based care, prolonged wait times to see specialists. Conclusions Participants depicted factors driving NA utilization among injured workers as complex. Patient-level factors were perceived as most influential on over-utilization, while system-level factors were considered most amenable to intervention. This has implications for intervention design, suggesting that systemic/structural factors should be taken into account in order to address this important health issue.

  18. Advancing current approaches to disease management evaluation: capitalizing on heterogeneity to understand what works and for whom.

    Science.gov (United States)

    Elissen, Arianne M J; Adams, John L; Spreeuwenberg, Marieke; Duimel-Peeters, Inge G P; Spreeuwenberg, Cor; Linden, Ariel; Vrijhoef, Hubertus J M

    2013-03-14

    Evaluating large-scale disease management interventions implemented in actual health care settings is a complex undertaking for which universally accepted methods do not exist. Fundamental issues, such as a lack of control patients and limited generalizability, hamper the use of the 'gold-standard' randomized controlled trial, while methodological shortcomings restrict the value of observational designs. Advancing methods for disease management evaluation in practice is pivotal to learn more about the impact of population-wide approaches. Methods must account for the presence of heterogeneity in effects, which necessitates a more granular assessment of outcomes. This paper introduces multilevel regression methods as valuable techniques to evaluate 'real-world' disease management approaches in a manner that produces meaningful findings for everyday practice. In a worked example, these methods are applied to retrospectively gathered routine health care data covering a cohort of 105,056 diabetes patients who receive disease management for type 2 diabetes mellitus in the Netherlands. Multivariable, multilevel regression models are fitted to identify trends in clinical outcomes and correct for differences in characteristics of patients (age, disease duration, health status, diabetes complications, smoking status) and the intervention (measurement frequency and range, length of follow-up). After a median one year follow-up, the Dutch disease management approach was associated with small average improvements in systolic blood pressure and low-density lipoprotein, while a slight deterioration occurred in glycated hemoglobin. Differential findings suggest that patients with poorly controlled diabetes tend to benefit most from disease management in terms of improved clinical measures. Additionally, a greater measurement frequency was associated with better outcomes, while longer length of follow-up was accompanied by less positive results. Despite concerted efforts to adjust

  19. 我国新修订GMP认证的现状、困境及对策研究%Research on current situation,difficulties and specific suggestions of certification of the new version of GMP

    Institute of Scientific and Technical Information of China (English)

    颜建周; 邵蓉

    2014-01-01

    This paper analyzed the current situation of GMP certification,concluding the difficulties and problems in certification process in terms of certification concepts,costs,financial sources and related mechanisms,providing specific suggestions on the basis of representative provinces such as Shandong. Suggested that we should change the enterprises′ negative attitude toward GMP certifica-tion,accelerate certification process;broaden financial sources to relieve the fund pressure of enterprises;set up full-time GMP inspec-tors pool to improve the efficiency of certification;perfect market withdrawal mechanism to eliminate the worries of enterprises.%本文在分析我国新修订GMP认证工作现状的基础上,从认证理念、认证成本、融资渠道和认证配套机制等方面总结了当前新修订GMP认证中遇到的困境。以此为依据,结合山东等典型省份的实践经验提出转变企业消极对待新修订GMP认证的观念,加快认证进度;开拓融资渠道,缓解企业认证资金压力;设置专职的GMP检查员队伍,提高认证效率;健全市场退出机制,消除拟退出企业后顾之忧等推进我国新修订GMP认证工作的政策建议。

  20. 大学英语ESP教学现状及发展建议%On the Current Teaching Condition of ESP Learning in the College English and Developing Suggestions

    Institute of Scientific and Technical Information of China (English)

    李然; 谢威

    2014-01-01

    改革开放使我国对外交流活动越来越丰富,与世界各国的频繁接触,使得各行各业急需许多既懂专业又懂英语的毕业生。因此专门用途英语ESP(English for specific purpose)成为了近年来研究的热点。本文论述了在高等院校进行英语ESP教学的现状以及相关的发展建议。%China’s reform and opening enriches its foreign exchange activities, and contacts with other countries frequently, resulting in all kinds of graduates who need to know professional knowledge and English knowledge. This makes ESP (English for specific purposes) a research highlight in recent years. This article talks about the current teaching condition of ESP learning in the college English and its developing suggestions.

  1. Theories of Suggestion.

    Science.gov (United States)

    Brown, W

    1928-02-01

    The word "suggestion" has been used in educational, scientific and medical literature in slightly different senses. In psychological medicine the use of suggestion has developed out of the earlier use of hypnotic influence.Charcot defined hypnosis as an artificial hysteria, Bernheim as an artificially increased suggestibility. The two definitions need to be combined to give an adequate account of hypnosis. Moreover, due allowance should be made for the factors of dissociation and of rapport in hypnotic phenomena.The relationships between dissociation, suggestibility, and hypnotizability.Theories of suggestion propounded by Pierre Janet, Freud, McDougall, Pawlow and others. Ernest Jones's theory of the nature of auto-suggestion. Janet explains suggestion in terms of ideo-motor action in which the suggested idea, because of the inactivity of competing ideas, produces its maximum effect. Freud explains rapport in terms of the sex instinct "inhibited in its aim" (transference) and brings in his distinction of "ego" and "ego-ideal" (or "super-ego") to supplement the theory. Jones explains auto-suggestion in terms of narcissism. McDougall explains hypnotic suggestion in terms of the instinct of self-abasement. But different instincts may supply the driving power to produce suggestion-effects in different circumstances. Such instincts as those of self-preservation (fear) and gregariousness may play their part. Auto-suggestion as a therapeutic factor is badly named. It supplements, but does not supplant the will, and makes complete volition possible.

  2. 高中生主动体育锻炼现状的调查与建议%Investigation and Suggestion on the current Situation of Active Physical Exercises in high school Students

    Institute of Scientific and Technical Information of China (English)

    刘子毅; 李惟英

    2016-01-01

    为了解高中生课余主动体育锻炼的现状,采用问卷调查和访谈的研究方法,对高中生的体育锻炼时间、频率、态度与所喜爱的项目、体育与健康知识的获取途径等一系列问题进行调查与访谈,从数据的角度分析高中生主动体育锻炼的现状,并对培养高中生主动体育锻炼的习惯给出一些建议,如加强课上体育与健康知识的传授、以及基于微信平台引导学生养成主动体育锻炼的方法等。%To understand the present situation of high school students extracurricular physical exercise initiative, using methods of questionnaires and interview investigation to explore a series of answers on high school students’ physical exercise time, frequency, attitude and favorite items sports and health knowledge acquirement. Analysis of the status quo of active exercise of high school students from the perspective of data. and this paper also gave some suggestions help cultivate the habit of physical exercise, such as strengthening teaching of physical and health knowledge in class, and guide students to develop active physical exercise habits through WeChat platform, etc.

  3. Understanding the Current International Order

    Science.gov (United States)

    2016-01-01

    Andrew, “Taking Preferences Seriously: A Liberal Theory of International Politics,” International Organization, Vol. 51, No. 4, Autumn 1997, pp...296. Snyder, Quddus Z., “Integrating Rising Powers: Liberal Systemic Theory and the Mechanism of Cooperation,” Review of International Studies, Vol. 39...institutions, bilateral and regional security organizations, and liberal political norms; these ordering mechanisms are often collectively referred to as

  4. The suggestion of "barefoot doctors" training model to the current rural health talent fostering%"赤脚医生"培养模式对当前农村医疗卫生人才培养的启示

    Institute of Scientific and Technical Information of China (English)

    孟庆书; 杨佳; 王晓燕; 吕兆丰

    2010-01-01

    "赤脚医生"是对我国农村人民公社时期"半农半医"医疗卫生人员的特定称谓,他们的工作在当时的中国社会为保障农民健康发挥了重要的作用.本文回顾了"赤脚医生"从产生到衰亡期间的教育发展历程,阐述了当时"赤脚医生"的教育培养模式,并从中汲取可资借鉴的经验;同时,本着"以史为鉴"的态度,针对当前乡村医生队伍中存在的业务素质偏低、人才流动明显等问题,提出了改变选拔方式、改进课程设置、加强中医药知识能力培训等建议.%"Barefoot doctors" is a specific title of "the half-time farm and half-time medical" sanitation personnel in the period of rural people' s communes. Their work had played an active role in the protection of the farmers health at the time in Chinese society. This article reviewed the "barefoot doctors"history of educational development from generation to recession and expounded the cultivated model of "barefoot doctors" and selected the best experience, adopted a "reflect on the past" attitude, put forward countermeasures and suggestions like changing the selection methods, improved the course setting and strengthened the cultivation of Chinese medicine for the current problems of village doctors with less capability and a significant loss of talents.

  5. Current Status of Doping in Japan Based on Japan Anti-Doping Disciplinary Panels of the Japan Anti-Doping Agency (JADA): A Suggestion on Anti-Doping Activities by Pharmacists in Japan.

    Science.gov (United States)

    Imanishi, Takashi; Kawabata, Takayoshi; Takayama, Akira

    2017-01-01

     In 2009, the Japan Anti-Doping Agency (JADA) established the "Sports Pharmacist Accreditation Program" to prevent doping in sports. Since then, anti-doping activities in Japan have been attracting attention. In this study, we investigated research about the current status of doping from 2007 to 2014 in Japan to make anti-doping activities more concrete, and we also discussed future anti-doping activities by pharmacists. In Japan, bodybuilding was the sporting event with the highest number and rate of doping from 2007 to 2014. Many of the positive doping cases were detected for class S1 (anabolic agents), S5 (diuretics and masking agents), and S6 (stimulants). Within class S1, supplements were the main cause of positive doping. Within class S5, medicines prescribed by medical doctors were the main cause of positive doping. Within class S6, non-prescription medicines (e.g., OTC) were the main cause of positive doping. When we looked at the global statistics on doping, many of the positive doping cases were detected for class S1. On comparing the Japanese statistics with the global statistics, the rate of positive doping caused by class S1 was significantly lower, but that caused by classes S5 and S6 was significantly higher in Japan than in the world. In conclusion, pharmacists in Japan should pay attention to class S1, S5, and S6 prohibited substances and to the sport events of bodybuilding. Based on this study, sports pharmacists as well as common pharmacists should suggest new anti-doping activities to prevent doping in the future.

  6. Suggested safeguards an

    African Journals Online (AJOL)

    MJM Venter

    ... COORDINATION. (FACILITATION OR CASE MANAGEMENT) IN SOUTH AFRICA ... SUGGESTED SAFEGUARDS AND LIMITATIONS FOR EFFECTIVE AND .... professional practice.27 They have to assess the situation; educate the parents.

  7. Manufacturer's Suggested Retail Prices

    NARCIS (Netherlands)

    Rosenkranz, S.

    2003-01-01

    Based on arguments of the `reference- dependent' theory of consumer choice we assume that a retailer's discount of a manufacturer's suggested retail price changes consumers' demand. We can show that the producer benefits from suggesting a retail price. If consumers are additionally sufficiently `los

  8. Air pollution toxicology--a brief review of the role of the science in shaping the current understanding of air pollution health risks.

    Science.gov (United States)

    Stanek, Lindsay Wichers; Brown, James S; Stanek, John; Gift, Jeff; Costa, Daniel L

    2011-03-01

    Human and animal toxicology has had a profound impact on our historical and current understanding of air pollution health effects. Early animal toxicological studies of air pollution had distinctively military or workplace themes. With the discovery that ambient air pollution episodes led to excess illness and death, there became an emergence of toxicological studies that focused on industrial air pollution encountered by the general public. Not only did the pollutants investigated evolve from ambient mixtures to individual pollutants but also the endpoints and outcomes evaluated became more sophisticated, resulting in our present state of the science. Currently, a large toxicological database exists for the effects of particulate matter and ozone, and we provide a focused review of some of the major contributions to the biological understanding for these two "criteria" air pollutants. A limited discussion of the toxicological advancements in the scientific knowledge of two hazardous air pollutants, formaldehyde and phosgene, is also included. Moving forward, the future challenge of air pollution toxicology lies in the health assessment of complex mixtures and their interactions, given the projected impacts of climate change and altered emissions on ambient conditions. In the coming years, the toxicologist will need to be flexible and forward thinking in order to dissect the complexity of the biological system itself, as well as that of air pollution in all its varied forms.

  9. Understanding Secondary Flows in Rivers Using a Combination of Acoustic Doppler Current Profiler Measurements and a Finite Volume solution to the Navier-Stokes Equations.

    Science.gov (United States)

    Furtak-Cole, E.

    2016-12-01

    Hydraulic processes in rivers are central to issues of river ecosystem health, contaminant transport, and essential to understanding meander dynamics. In particular, large scale secondary flows are often cited as being the driving force behind river bend shape and migration. We seek to understand the fundamental flow patterns in rivers by augmenting field-collected bathymetry and velocity data with computational fluid dynamics (CFD) simulation. This approach has successfully been applied to flume studies, but rarely used in a natural setting. Here, complex geometries, lack of data, large woody debris, riprap, and biased measurements all present difficulties. Velocity and bathymetry data were collected over multiple consecutive days on a reach of the Minnesota river in Belle Plaine with an acoustic Doppler current profiler (ADCP). Time averaging and interpolation of velocity vectors along transects reveal coarse scale secondary flow patterns, including an outer bank cell. A mesh was created from bathymetry data for use with the openFOAM C++ library. A hydraulics study is conducted by solving the Navier-Stokes equations with a slip condition free-surface and large eddy simulation turbulence model. Results are compared to field-measured data, and areas affected by downed trees and riprap are identified. We show that modelling at the coarse scale can provide useful information for understanding river hydraulics and predicting sediment transport over large domains.

  10. Understanding Alzheimer's

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues Understanding Alzheimer's Past Issues / Fall 2007 Table of Contents For ... and brain scans. No treatment so far stops Alzheimer's. However, for some in the disease's early and ...

  11. Genetic analysis of streptomycin-resistant (Sm(R)) strains of Erwinia amylovora suggests that dissemination of two genotypes is responsible for the current distribution of Sm(R) E. amylovora in Michigan.

    Science.gov (United States)

    McGhee, Gayle C; Guasco, Jesse; Bellomo, Lisa M; Blumer-Schuette, Sara E; Shane, William W; Irish-Brown, Amy; Sundin, George W

    2011-02-01

    Streptomycin-resistant (Sm(R)) strains of the fire blight pathogen Erwinia amylovora were first isolated in southwest Michigan in 1991. Since that time, resistant strains have progressed northward to other apple-producing regions in the state. A total of 98.7% of Sm(R) strains isolated between 2003 and 2009 in Michigan harbored the strA-strB genes on transposon Tn5393. strA and strB encode phosphotransferase enzymes that modify streptomycin to a nonbactericidal form. Mutational resistance to streptomycin, caused by a point mutation-mediated target-site alteration of the ribosomal S12 protein, occurred in 1.3% of E. amylovora strains from Michigan. Tn5393 was originally introduced to E. amylovora on the plasmid pEa34; thus, the first Sm(R) strains isolated contained both pEa34 and the ubiquitous nonconjugative plasmid pEA29. More recently, we have observed Sm(R) strains in which Tn5393 is present on pEA29, suggesting that the transposon has moved via transposition from pEa34 to pEA29. Almost all of the strains containing Tn5393 on pEA29 had lost pEa34. Of 210 pEA29::Tn5393 plasmids examined, the transposon was inserted at either nucleotide position 1,515 or 17,527. Both of these positions were in noncoding regions of pEA29. Comparative sequencing of the housekeeping genes groEL and potentially variable sequences on pEA29 was done in an attempt to genetically distinguish Sm(R) strains from streptomycin-sensitive (Sm(S)) strains isolated in Michigan. Only 1 nucleotide difference within the total 2,660 bp sequenced from each strain was observed in 2 of 29 strains; multiple sequence differences were observed between the Michigan strains and E. amylovora control strains isolated in the western United States or from Rubus spp. Alterations in virulence observable using an immature pear fruit assay were detected in three of eight Sm(R) strains examined. Our current genetic data indicate that only two Sm(R) strain genotypes (strains containing pEA29::Tn5393 with Tn5393

  12. Research Suggestions for Students

    Science.gov (United States)

    Holland, John L.

    1974-01-01

    Describes how to perform accurate research. Also includes suggestions for specific research projects under such headings as: (1) types; (2) environments; (3) interactions; (4) classification; (5) hexagonal model; and (6) differentiation. (HMV)

  13. Open to Suggestion.

    Science.gov (United States)

    Journal of Reading, 1984

    1984-01-01

    Contributors offer suggestions concerning parents as reading stimulators, book discussions, a test bank for the secondary school/college reading lab, standardized reading tests, television reading, plagiarism, vocabulary development, and book reports. (FL)

  14. Open To Suggestion.

    Science.gov (United States)

    Journal of Reading, 1988

    1988-01-01

    Suggests class activities in three short articles including: (1) "Students Evaluate Reading," by Lenore Sandel; (2) "Solving Verbal Analogies," by Edward J. Dwyer; and (3) "Becoming Testwise," by Dean Schoen. (RS)

  15. Understanding and Suggestions on the Current Formal Rules for Bibliographic References%关于现行参考文献著录规则的形式化认识及建议

    Institute of Scientific and Technical Information of China (English)

    谷松; 张静雅; 赵丽新

    2014-01-01

    本文从形式化系统和《标准化工作导则:第1部分:标准的结构和编写规则》的两个方面考虑了GB/T 7714-2005《文后参考文献著录规则》的著录符号和著录规则等问题,指出了《文后参考文献著录规则》著录符号、著录规则中存在的内部不一致性,并且从实用性角度出发,指出了其中相对完备性不足及不够简明等问题。最后,给出了关于消除不一致性和简化著录方面的几点建议。%This paper re-considers about the symbols and rules of GB/T 7714-2005 “Rules for content, form and structure of bibliographic references” from perspective of formal system and “Directives for standardization—Part 1: Rules for the structure and drafting of standards” and points out problems that can result in internal inconsistencies. The paper practically underlines the lack of relative completeness and simplicity in symbols and rules of “Rules for content, form and structure of bibliographic references”. Finally, some proposals are put forward to simplify and eliminate internal inconsistencies.

  16. Suggestions for Teaching Practice

    Institute of Scientific and Technical Information of China (English)

    ZHAN Na-na

    2013-01-01

    Teacher development and teaching practice(TP) have caught the eyes of researchers at home and abroad for many years. Many western scholars hold that reflective teaching is an efficient way to promote teacher development, but traditional TP is prevailing in China. Based on the merits and demerits of traditional TP and reflective TP, the author hopes to provide some suggestions for the people involved to promote the development of teacher education.

  17. Understanding of the Current Long-term Care Policy in China%理解我国现阶段的长期照护政策

    Institute of Scientific and Technical Information of China (English)

    房莉杰

    2015-01-01

    以全面了解目前中国的长期照护政策,从制度发展的角度理解其处境、问题及未来趋势为研究目的,回顾了主要相关文献、政府政策文件,并对全国统计数据进行了对比。研究表明:我国进入21世纪以来,长期照护产生和发展背景是需求迅速增加,且原有服务能力不足,因此我国长期照护政策是从服务机构“能力建设”起步。发展至今,一方面服务数量增加、内容丰富、形成多元提供的格局;另一方面,很多服务需求仍没有得到释放,公平性差,服务机构的持续发展也存在隐患。问题的根源在于空有能力建设,而制度建设不足,尤其是筹资制度。%With the purpose of understanding the current long-term care policy and understanding its position, problems and developing trend with an institutional from the perspective of the transition. This paper reviews the main related papers, the government policy document and compares the national statistical data. Since the entrance of the 21st century, the supply of long-term care needs the rapid development and now it is far from adequate. The construction of the long-term new care system has been started with capacity building ten years ago. Understanding the long-term care policy in current China, on one hand, the institutional care and the community care has both developed fast;but on the other hand, the absence of a stable policy scheme has more and more obstructed the sustainable development of the long-term care.

  18. Current Public Knowledge Pertaining to Traumatic Brain Injury: Influence of Demographic Factors, Social Trends, and Sport Concussion Experience on the Understanding of Traumatic Brain Injury Sequelae.

    Science.gov (United States)

    Merz, Zachary C; Van Patten, Ryan; Lace, John

    2017-03-01

    The current study aimed to assess current broad traumatic brain injury (TBI)-related knowledge in the general public, as well as understanding regarding specific TBI-related conditions including post-concussive syndrome (PCS) and chronic traumatic encephalopathy (CTE). Data were collected from 307 domestic and 73 international individuals via online researcher-developed survey instrumentation utilizing the Amazon Mechanical Turk marketplace, a recently developed website that allows for a streamlined process of survey-based participant recruitment and data collection. Participants completed background demographics questions, a 31-item true/false questionnaire pertaining to TBI-related knowledge, and an inquiry related to willingness to allow (future) child(ren) to participate in several popular U.S. sports. The overall accuracy rate of our U.S. sample was 61%. No accuracy differences were present for gender or geographic region (p's > .05). Participants who self-reported a prior concussion diagnosis, who reported receiving formal concussion training, and who endorsed participation in collegiate, semi-professional, or professional athletic competition, all exhibited lower accuracy rates than the respective comparison groups (p's < .001). Finally, individual item analysis revealed the presence of significant misconceptions pertaining to PCS and CTE. Misconceptions regarding TBI remain highly prevalent within the general public and may be explained, to some extent, by inefficiencies in current TBI-education practices. Moreover, misconceptions regarding PCS and CTE are also prevalent and likely reflect inconsistencies in the scientific literature, coupled with misleading media reports. To combat these trends, greater emphasis must be placed on construct definition within the field and streamlined, efficient communication with the general public.

  19. [Evidence of work-related musculo-skeletal disorders of the upper extremities and current methods of risk assessment: can Charlie Chaplin give us any suggestions in "modern times"].

    Science.gov (United States)

    Apostoli, P; Sala, Emma

    2009-01-01

    in some sequences of the film "Modern Times" Chaplin is clearly involved in activities at high risk for work-related musculo-skeletal disorders of the upper extremities (UEWMSDs), but evidence and perception of any complaint are not evident. To evaluate the extent of the biomechanical risk using current risk assessment methods and discuss the possible reasons for lack of complaints. we made an analysis using six of the current methods for ergonomic risk assessment (State of Washington, check list OCRA, HAL by ACGIH, RULA Strain Index, OREGE). All the methods applied demonstrated high-to-very high levels of biomechanical risk for the upper extremities, with evident psychic effects but without apparent musculo-skeletal disorders. The discrepancy between evident psychological disorders ad apparent absence of UEWMSDs are discussed as being due to either: an artistic choice by Charlie Chaplin who focused on the aspects thought to be more immediately and easily comic; the short duration of the physical load exertion; or because of a different perception of muscular work and fatigue that was also typical until the 1970's and 1980's, which also confirmed the principles and practices of our preventive and medical disciplines at that time.

  20. First-year university Physics students’ knowledge about direct current circuits: probing improvement in understanding as a function of teaching and learning interventions

    Science.gov (United States)

    Newman, Richard; van der Ventel, Brandon; Hanekom, Crischelle

    2017-07-01

    Probing university students’ understanding of direct-current (DC) resistive circuits is still a field of active physics education research. We report here on a study we conducted of this understanding, where the cohort consisted of students in a large-enrollment first-year physics module. This is a non-calculus based physics module for students in the life sciences stream. The study involved 366 students enrolled in the physics (bio) 154 module at Stellenbosch University in 2015. Students’ understanding of DC resistive circuits was probed by means of a standardized test instrument. The instrument comprises 29 multiple choice questions that students have to answer in ~40 min. Students were required to first complete the standardized test at the start of semester (July 2015). For ease of reference we call this test the pre-test. Students answered the pre-test having no university-level formal exposure to DC circuits in theory or practice. The pre-test therefore served to probe students’ school level knowledge of DC circuits. As the semester progressed students were exposed to a practical (E1), lectures, a prescribed textbook, a tutorial and online videos focusing on DC circuits. The E1 practical required students to solve DC circuit problems by means of physically constructing circuits, algebraically using Kirchhoff's Rules and Ohm’s Law, and by means of simulating circuits using the app iCircuit running on iPads (iOS platform). Each E1 practical involved ~50 students in a three hour session. The practical was repeated three afternoons per week over an eight week period. Twenty three iPads were distributed among students on a practical afternoon in order for them to do the circuit simulations in groups (of 4-5 students). At the end of the practical students were again required to do the standardized test on circuits and complete a survey on their experience of the use of the iPad and iCircuit app. For ease of reference we refer to this second test as the

  1. Guiyang modern logistics industry and regional economic coordinated development of the Current Situation and Suggestions%贵阳市现代物流业与区域经济协调发展现状及对策建议

    Institute of Scientific and Technical Information of China (English)

    曾方俊

    2012-01-01

    根据现代物流业与区域经济协调发展的重要性和内在机理,对贵阳市现代物流业与区域经济发展现状进行调研,针对存在的问题,提出了相关对策建议。%According to the importance of the modem logistics industry and the coordinated development of regional economy and the internal mechanism of Guiyang City, the modem logistics industry and regional economic development research, development and put forward relevant suggestions for possible problems.

  2. Critical assessment of the current understanding/ knowledge of the framework of the Ecosystem Approach to Fisheries in the Mediterranean and Black Seas

    Directory of Open Access Journals (Sweden)

    Paolo Sartor

    2014-03-01

    Full Text Available A critical review was carried out involving experts from 17 countries, to identify, summarize and evaluate the current understanding related to the Ecosystem Approach to Fisheries management (EAF in the Mediterranean and Black Seas. The existing information available at country level, coming from research and monitoring projects and other types of activities, was explored. The evaluation was done following a standardized protocol and using simple semi-quantitative methods. The results highlighted an overall low-medium degree of fulfilment of the requirements of the EAF, with some differences related to the different issues considered. The highest scores were reported for the knowledge related to fleet structure/ behaviour and species/habitat distribution, whereas the lowest scores were reported for modelling, and socio-economic and management issues. Although only semi-quantitative, these results provided an initial picture at a broad regional level on the state of knowledge with a view to a proper implementation of the EAF in the Mediterranean and Black Seas, and identified gaps in scientific knowledge that should be covered.

  3. 转基因主粮商业化对现行法律的挑战与对策分析%Challenges of Commercialization of Genetically Modified Staple Foods to Current Laws and Suggestions

    Institute of Scientific and Technical Information of China (English)

    付文佚

    2014-01-01

    The commercialization of genetically modified (GM)staple foods is a critical issue concerning the national economy and people’s livelihood.Today debates are focusing on whether or not to commercialize GMsta-ple foods,and seldom on the huge drawbacks of current law facing with commercialization.After a comprehen-sively analysis current rules on GM crops and foods,huge drawbacks are found in ideas,measures,procedures and remedies in legal system.Reasons for legislation dilemma are due to GMprocess,hard to distinction between GMand non GMproducts,also huge interests’conflicts exist in staple food.Before pushing commercialization of GMstaple foods,legislation must change,including guiding ideas and principles being modified,special law and new measures being regulated,with more information transparency and public engagement,increasing punishment and identifying the tort liability etc.In conclusion,current laws are not sufficient for the commercialization of GM staple foods.If decisions are rashly made,huge and irreversible damage may result.%转基因主粮的商业化是涉及国计民生的重大问题,舆论上对其是否商业化争论不休,少有研究涉及当前法律在商业化情形下存在的巨大不足。现行的转基因法律、法规和规章在法律理念、法律制度、法律程序和法律救济方面等存在诸多问题。转基因作为生产过程,在区分困难的客观特性和主粮问题上根本利益的严重冲突导致转基因立法的举步维艰。转基因主粮商业化决策之前,必须先进行法律的整体更新和完善,包括转变立法理念,确定法律原则,通过专门立法、革新法律制度,完善信息公开、增加公众参与,加重违法成本、明确侵权责任等。总之,我国目前现尚不具备转基因主粮商业化的法律环境,贸然推行商业化,将带来严重危害后果。

  4. The Indicator Amino Acid Oxidation Method with the Use of l-[1-13C]Leucine Suggests a Higher than Currently Recommended Protein Requirement in Children with Phenylketonuria.

    Science.gov (United States)

    Turki, Abrar; Ueda, Keiko; Cheng, Barbara; Giezen, Alette; Salvarinova, Ramona; Stockler-Ipsiroglu, Sylvia; Elango, Rajavel

    2017-02-01

    Phenylketonuria is characterized by mutations in the Phe hydroxylase gene that leads to the accumulation of Phe in plasma and the brain. The standard of care for phenylketonuria is nutritional management with dietary restriction of Phe and the provision of sufficient protein and energy for growth and health maintenance. The protein requirement in children with phenylketonuria is empirically determined based upon phenylketonuria nutritional guidelines that are adjusted individually in response to biochemical markers and growth. We determined dietary protein requirements in children with phenylketonuria with the use of the indicator amino acid oxidation (IAAO) technique, with l-[1-(13)C]Leu as the indicator amino acid. Four children (2 males; 2 females) aged 9-18 y with phenylketonuria [mild hyperphenylalanemia (mHPA); 6-10 mg/dL (360-600 μmol/L)] were recruited to participate in ≥7 separate test protein intakes (range: 0.2-3.2 g ⋅ kg(-1) ⋅ d(-1)) with the IAAO protocol with the use of l-[1-(13)C]Leu followed by the collection of breath and urine samples over 8 h. The diets were isocaloric and provided energy at 1.7 times the resting energy expenditure. Protein was provided as a crystalline amino acid mixture based on an egg protein pattern, except Phe and Leu, which were maintained at a constant across intakes. Protein requirement was determined with the use of a 2-phase linear-regression crossover analysis of the rate of l-[1-(13)C]Leu tracer oxidation. The mean protein requirement was determined to be 1.85 g ⋅ kg(-1) ⋅ d(-1) (R(2) = 0.66; 95% CI: 1.37, 2.33). This result is substantially higher than the 2014 phenylketonuria recommendations (1.14-1.33 g ⋅ kg(-1) ⋅ d(-1); based on 120-140% above the current RDA for age). To our knowledge, this is the first study to directly define a quantitative requirement for protein intake in children with mHPA and indicates that current protein recommendations in children with phenylketonuria may be insufficient

  5. A combined field and numerical approach to understanding dilute pyroclastic density current dynamics and hazard potential: Auckland Volcanic Field, New Zealand

    Science.gov (United States)

    Brand, Brittany D.; Gravley, Darren M.; Clarke, Amanda B.; Lindsay, Jan M.; Bloomberg, Simon H.; Agustin-Flores, Javier; Németh, Károly

    2014-04-01

    less damage is expected up to the final runout distance of 4 km. For larger eruptions (base surge runout distance 4-6 km), Pdyn of > 35 kPa can be expected up to 2.5 km from source, ensuring complete destruction within this area. Moderate damage to reinforced structures and damage to weaker structures can be expected up to 6 km from source. In both cases hot ash may still cause damage due to igniting flammable materials in the distal-most regions of a base surge. This work illustrates our ability to combine field observations and numerical models to explore the depositional mechanisms, macroscale current dynamics, and potential impact of dilute PDCs. Thus, this approach may serve as a tool to understand the damage potential and extent of previous and potential future eruptions in the AVF.

  6. 流通产业数据统计的现状、问题及改进建议%Current Situation and Problems of Statistics in Distribution Industry and Suggestions for Improvement

    Institute of Scientific and Technical Information of China (English)

    张昊

    2014-01-01

    流通领域的数据统计对于产业自身发展和宏观经济预测都具有极其重要的价值。目前,我国流通统计指标体系已经基本形成,但其数据内容、来源及发布方式等仍有改进的必要。应当以接轨国际标准的行业分类为基础,在“大流通”视野中确定流通产业的行业范围,进而建立由共性指标、个性指标构成的有机统一的指标体系。同时,有必要梳理、协调政府及相关机构目前发布的数据内容,通过“云技术”实现统筹与整合。并且,要明晰数据的来源渠道、采集方式,将重复矛盾转变为差异互补。在这一过程中,应当充分挖掘经济普查数据的利用价值,发挥非官方机构的补充作用,使流通统计更加全面、透明,为问题导向的分析研究提供更好的支撑。%Statistics in distribution area is of great importance both for the development of industry and macroeconomic forecasts. Currently,the statistical indicator system has been basically formed,but improvement is still needed for its data contents,sources and publication methods. According to international standards,the industry scope of‘enlarged distribution system’should be determined,and based on industry classification,an organically consolidated indicator system which includes both common and special indicators should be built. Meanwhile,it is necessary to rearrange and coordinate the contents of the data currently published by government and related organizations,and an integration could be achieved by using the"cloud tech". The source and collection method of data should also be made clear,so as to change the situation of data publication from repeated or contradictory into differentiated and complementary. In this process,the value of economic census data should be cherished and the NGOs can also play a supplementary role,so that the statistics can be made more comprehensive and transparent,thus providing

  7. Current Situation, Problem and Suggestion in the Tractor Driver-training in Anhui Province%安徽省拖拉机驾驶培训的现状·问题与建议

    Institute of Scientific and Technical Information of China (English)

    管志俊

    2016-01-01

    The existing common problem in the process of driver-training such as the training and check, the training hours-setting, the teaching material, the practical machinery, the policy support and others and its causes were analyzed through the analysis of the historical review and cur-rent status in Anhui tractor driver-training and then the recommendation was put forward. The tractor driver-training should be one kind of public service activity. The R&D and management of teaching material and coach equipment should be strengthened. The process of training and ac-creditation should be reformed, and the management of software should be promoted, the subsidies for tractor-purchasing should be optimized, so that the tractor driver-training would be more scientific, reasonable and efficient.%通过对安徽省拖拉机驾驶培训的历史回顾和现状的梳理,分析在培训考证流程、学时设置、教材建设、实习机具、政策支持等方面存在的共性问题及成因,进而提出相关建议,要求回归拖拉机驾驶培训的公益性,加强教材教法建设和教练机具的研发和管理,改革和完善现有的培训办证流程,推广软件化管理,优化购机补贴政策,促使今后的拖拉机驾驶培训工作更加科学、合理和高效。

  8. 基于SWOT模型的四川创新团队发展现状分析及建议%Analysis on Current Status of Innovation Team Development in Sichuan Province Based on SWOT Model and Suggestions

    Institute of Scientific and Technical Information of China (English)

    景晓卫; 李晓; 雷波

    2015-01-01

    加强四川创新团队建设是提升科技支撑产业发展、促进农业产业提档升级的有效方式.文章采用SWOT模型分析了四川创新团队在科研力量、优势产业和管理方式等方面的优势,以及在科技协作、经费投入等方面的劣势.提出了通过加强组织领导和管理创新、突出成果转化应用和大力培育新型职业农民等促进四川创新团队健康、持续发展的建议.%Strengthening the construction of innovation team is the effective way of promoting the development of scientific supporting industry and accelerating the upgrade of agricultural industry. In this article, innovation team of Sichuan Province was analyzed by SWOT model, which has advantages in scientific research force, superior industry and management mode, and has main obstacles in cooperative mode and fund input. Suggestions to promote healthy and sustainable development of innovation team in Sichuan Province were put forward, i.e., strengthening the organization leadership and management innovation, laying stress on transformation and application of achievements, and cultivating new type of professional farmers.

  9. 供电营业网点建设现状分析及建议%Analysis on the Current Situation of Power Supply Outlets Construction and Its Suggestions

    Institute of Scientific and Technical Information of China (English)

    杜雅飞

    2015-01-01

    本文通过深入研究"大营销"体系建成以来营业网点在管理标准、网点布局、软硬件设施及人员配备等方面存在的问题,按照"大营销"体系建设中"城乡一体化"的发展要求,结合近年来"城市十分钟缴费圈"、"农村村村布点"等多元化缴费渠道和代收网点的建设标准,给供电营业网点建设提出参考建议.%In this paper, through the deep research of the existing problems in management standard, site layout, hardware and software facilities, staffing accouterment and other aspects of the business outlets after the "big marketing" system construction, according to the development requirements of "urban-rural integration" in the "big marketing" system construction, combined with the construction standard of "ten-minute capture expends circle of cities", "outlets in every village" and other diversified payment channels and outlets, the suggestions of power supply outlets construction are put forward.

  10. Asthma in the elderly: Current understanding and future research needs--a report of a National Institute on Aging (NIA) workshop.

    Science.gov (United States)

    Hanania, Nicola A; King, Monroe J; Braman, Sidney S; Saltoun, Carol; Wise, Robert A; Enright, Paul; Falsey, Ann R; Mathur, Sameer K; Ramsdell, Joe W; Rogers, Linda; Stempel, David A; Lima, John J; Fish, James E; Wilson, Sandra R; Boyd, Cynthia; Patel, Kushang V; Irvin, Charles G; Yawn, Barbara P; Halm, Ethan A; Wasserman, Stephen I; Sands, Mark F; Ershler, William B; Ledford, Dennis K

    2011-09-01

    Asthma in the elderly is underdiagnosed and undertreated, and there is a paucity of knowledge on the subject. The National Institute on Aging convened this workshop to identify what is known and what gaps in knowledge remain and suggest research directions needed to improve the understanding and care of asthma in the elderly. Asthma presenting at an advanced age often has similar clinical and physiologic consequences as seen with younger patients, but comorbid illnesses and the psychosocial effects of aging might affect the diagnosis, clinical presentation, and care of asthma in this population. At least 2 phenotypes exist among elderly patients with asthma; those with longstanding asthma have more severe airflow limitation and less complete reversibility than those with late-onset asthma. Many challenges exist in the recognition and treatment of asthma in the elderly. Furthermore, the pathophysiologic mechanisms of asthma in the elderly are likely to be different from those seen in young asthmatic patients, and these differences might influence the clinical course and outcomes of asthma in this population.

  11. Correctly Understanding and Choosing the Current Parameter of Low-voltage Circuit Breaker%正确理解和选择低压断路器的电流参数

    Institute of Scientific and Technical Information of China (English)

    李远景

    2011-01-01

    低压断路器在配电系统中起着十分重要的作用,低压断路器保护特性的实验加深了学生对理论知识的理解,锻炼了动手能力,对此分析低压断路器的各个电流参数的概念、特性及其作用,帮助从事电气设计、采购、施工和监理工作人员正确理解断路器参数的意义和确定参数,提出更好的意见和建议.%Low-voltage circuit breaker plays a very important role in the distribution system.The experiment of low-voltage circuit breaker deepens students' understanding of theoretical knowledge and practice ability.The concept, feature and function of current parameter of low-voltage breaker are analyzed to help the staff in electrical design, procurement, construction and supervision industry correctly understand the meaning of circuit breaker and the ensuring of the parameters which better suggestions are proposed.

  12. Current Status , Problems and Suggestions on Climate Change Adaptation Actions in Sichuan Province%四川省气候变化适应行动现状、问题和建议研究

    Institute of Scientific and Technical Information of China (English)

    田梅; 冉春红; 李映果; 赵毅峰; 杨光炜

    2016-01-01

    The effective development of local climate change adaptation action is an important guarantee to ensure the imple-mentation of climate change adaptation strategies and objectives.As one of the more serious province which suffering from the ad-verse effects of climate change, Sichuan province is facing the challenge of enhancing the ability of sustainable development and responding the new climate change risk, how to maintain the economic development while establishing a low carbon development model of climate change is a realistic and urgent task for the economic and social development of our province .Based on the brief description of climate change impacts on Sichuan province as well as the Sichuan province's climate change adaptation achieve-ments, the paper further analyzed the problems about the adaptation to climate change , it was found that the policies and work mechanism for adaptation work had not been perfected, the lack of funding was difficult to provide long -term security mecha-nisms, infrastructure construction could not meet the needs of the adaptation, foundation support capacity was relatively weak, etc.Finally, several suggestions were put forward for further strengthening Sichuan province's climate change adaptation actions, such as:Strengthening policies and regulations for climate change adaptation;accelerating the improvement of institutional mecha-nisms for climate change adaptation; Increasing financial investment and financial support; enhancing the construction of the in-frastructure and condition platform to adapt for climate change; strengthening capacity building for climate change adaptation.%作为遭受气候变化不利影响较为严重的省份之一,四川省面临着可持续发展能力提升和应对新增气候变化风险的挑战.文章在简要介绍气候变化对四川省的影响、系统梳理其在适应气候变化中取得成效的基础上,进一步剖析了存在的问题,最后结合四川省省情和气候变

  13. Teaching Teaching & Understanding Understanding

    DEFF Research Database (Denmark)

    2006-01-01

    "Teaching Teaching & Understanding Understanding" is a 19-minute award-winning short-film about teaching at university and higher-level educational institutions. It is based on the "Constructive Alignment" theory developed by Prof. John Biggs. The film delivers a foundation for understanding what...

  14. Teaching Teaching & Understanding Understanding

    DEFF Research Database (Denmark)

    2006-01-01

    "Teaching Teaching & Understanding Understanding" is a 19-minute award-winning short-film about teaching at university and higher-level educational institutions. It is based on the "Constructive Alignment" theory developed by Prof. John Biggs. The film delivers a foundation for understanding what...

  15. Current Status and Suggestions of China's Refractories Industry

    Institute of Scientific and Technical Information of China (English)

    XU Dianli

    2009-01-01

    @@ China' s economy has developed rapidly since joined WTO in 2000.Influenced by the rapid development of high temperature industries such as metallurgy,building material,nonferrous metal,etc.,China's refractories industry has its production and sales boomed,benefit enhanced and industrial structure adjusted.

  16. Understanding the densification process of Bi2Sr2CaCu2O x round wires with overpressure processing and its effect on critical current density

    Science.gov (United States)

    Matras, M. R.; Jiang, J.; Larbalestier, D. C.; Hellstrom, E. E.

    2016-10-01

    Overpressure (OP) processing increases the critical current density ({{\\boldsymbol{J}}}{{C}}) of Bi2Sr2CaCu2O x (2212) round wires by shrinking the surrounding Ag matrix around the 2212 filaments, driving them close to full density and greatly increasing the 2212 grain connectivity. Indeed densification is vital for attaining the highest {{\\boldsymbol{J}}}{{C}}. Here, we investigate the time and temperature dependence of the wire densification. We find that the wire diameter decreases by 3.8 ± 0.3% after full heat treatment at 50 atm and 100 atm OP. At 50 atm OP pressure, the filaments start densifying above 700 °C and reach a 3.30 ± 0.07% smaller diameter after 2 h at 820 °C, which is below the melting point of 2212 powder. The densification is homogeneous and does not change the filament shape before melting. The growth of non-superconducting phases is observed at 820 °C, suggesting that time should be minimized at high temperature prior to melting the 2212 powder. Study of an open-ended 2.2 m long wire sample shows that full densification and the high OP {{\\boldsymbol{J}}}{{C}} ({{\\boldsymbol{J}}}{{C}} varies by about 3.1 times over the 2.2 m long wire) is reached about 1 m from the open ends, thus showing that coil-length wires can be protected from leaky seals by adding at least 1 m of sacrificial wire at each end.

  17. Current Views and Perspectives on E-Mental Health: An Exploratory Survey Study for Understanding Public Attitudes Toward Internet-Based Psychotherapy in Germany.

    Science.gov (United States)

    Apolinário-Hagen, Jennifer; Vehreschild, Viktor; Alkoudmani, Ramez M

    2017-02-23

    Despite the advanced development of evidence-based psychological treatment services, help-seeking persons with mental health problems often fail to receive appropriate professional help. Internet-delivered psychotherapy has thus been suggested as an efficient strategy to overcome barriers to access mental health care on a large scale. However, previous research indicated poor public acceptability as an issue for the dissemination of Internet-delivered therapies. Currently, little is known about the expectations and attitudes toward Internet-delivered therapies in the general population. This is especially the case for countries such as Germany where electronic mental health (e-mental health) treatment services are planned to be implemented in routine care. This pilot study aimed to determine the expectations and attitudes toward Internet-based psychotherapy in the general population in Germany. Furthermore, it aimed to explore the associations between attitudes toward Internet-based therapies and perceived stress. To assess public attitudes toward Internet-based psychotherapy, we conducted both Web-based and paper-and-pencil surveys using a self-developed 14-item questionnaire (Cronbach alpha=.89). Psychological distress was measured by employing a visual analogue scale (VAS) and the 20-item German version of the Perceived Stress Questionnaire (PSQ). In addition, we conducted explorative factor analysis (principal axis factor analysis with promax rotation). Spearman's rank correlations were used to determine the associations between attitudes toward Internet-based therapies and perceived stress. Descriptive analyses revealed that most respondents (N=1558; female: 78.95%, 1230/1558) indicated being not aware of the existence of Internet-delivered therapies (83.46%, 1141/1367). The average age was 32 years (standard deviation, SD 10.9; range 16-76). Through exploratory factor analysis, we identified 3 dimensions of public attitudes toward Internet-based therapies

  18. Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma: a review of the current understanding of epidemiology, biology, risk stratification, and management of myeloma precursor disease.

    Science.gov (United States)

    Agarwal, Amit; Ghobrial, Irene M

    2013-03-01

    The term monoclonal gammopathy of undetermined significance (MGUS) was coined in 1978. The recent advances in our knowledge about MGUS and smoldering multiple myeloma (SMM) have helped us better understand the pathogenesis of myeloma. It seems that myeloma evolves from a precursor state in almost all cases. We do not completely understand the multistep process from the precursor state to myeloma, but studies like whole genome sequencing continue to improve our understanding of this process. The process of transformation may not be linear acquisition of changes, but rather a branched heterogeneous process. Clinical features that are prognostic of rapid transformation have been identified, but no specific molecular markers have been identified. Even with recent advances, multiple myeloma remains an incurable disease in the vast majority, and intervening at the precursor state provides a unique opportunity to alter the natural history of the disease. A limitation is that a vast majority of patients with precursor disease, especially low-risk MGUS, will never progress to myeloma in their lifetime, and treating these patients is not only unnecessary but may be potentially harmful. The challenge is to identify a subset of patients with the precursor state that would definitely progress to myeloma and in whom interventions will have a meaningful impact. As our understanding of the molecular and genetic processes improves, these studies will guide the selection of high-risk patients more appropriately and ultimately direct a tailored management strategy to either delay progression to symptomatic myeloma or even "cure" a person at this premalignant stage.

  19. Current Views and Perspectives on E-Mental Health: An Exploratory Survey Study for Understanding Public Attitudes Toward Internet-Based Psychotherapy in Germany

    Science.gov (United States)

    Vehreschild, Viktor; Alkoudmani, Ramez M

    2017-01-01

    Background Despite the advanced development of evidence-based psychological treatment services, help-seeking persons with mental health problems often fail to receive appropriate professional help. Internet-delivered psychotherapy has thus been suggested as an efficient strategy to overcome barriers to access mental health care on a large scale. However, previous research indicated poor public acceptability as an issue for the dissemination of Internet-delivered therapies. Currently, little is known about the expectations and attitudes toward Internet-delivered therapies in the general population. This is especially the case for countries such as Germany where electronic mental health (e-mental health) treatment services are planned to be implemented in routine care. Objective This pilot study aimed to determine the expectations and attitudes toward Internet-based psychotherapy in the general population in Germany. Furthermore, it aimed to explore the associations between attitudes toward Internet-based therapies and perceived stress. Methods To assess public attitudes toward Internet-based psychotherapy, we conducted both Web-based and paper-and-pencil surveys using a self-developed 14-item questionnaire (Cronbach alpha=.89). Psychological distress was measured by employing a visual analogue scale (VAS) and the 20-item German version of the Perceived Stress Questionnaire (PSQ). In addition, we conducted explorative factor analysis (principal axis factor analysis with promax rotation). Spearman’s rank correlations were used to determine the associations between attitudes toward Internet-based therapies and perceived stress. Results Descriptive analyses revealed that most respondents (N=1558; female: 78.95%, 1230/1558) indicated being not aware of the existence of Internet-delivered therapies (83.46%, 1141/1367). The average age was 32 years (standard deviation, SD 10.9; range 16-76). Through exploratory factor analysis, we identified 3 dimensions of public

  20. Understanding Readers' Differing Understandings

    Science.gov (United States)

    Kucer, Stephen B.

    2015-01-01

    This research examines the characteristics of reader understandings that vary from those stated in the text. Eighty-seven fourth graders orally read complex academic literary and scientific texts, followed by probed retellings. Retold ideas not directly supported by, or reflective of, the texts were identified. These differing understandings…

  1. Motor Cortex and Motor Cortical Interhemispheric Communication in Walking After Stroke: The Roles of Transcranial Magnetic Stimulation and Animal Models in Our Current and Future Understanding.

    Science.gov (United States)

    Charalambous, Charalambos C; Bowden, Mark G; Adkins, DeAnna L

    2016-01-01

    Despite the plethora of human neurophysiological research, the bilateral involvement of the leg motor cortical areas and their interhemispheric interaction during both normal and impaired human walking is poorly understood. Using transcranial magnetic stimulation (TMS), we have expanded our understanding of the role upper-extremity motor cortical areas play in normal movements and how stroke alters this role, and probed the efficacy of interventions to improve post-stroke arm function. However, similar investigations of the legs have lagged behind, in part, due to the anatomical difficulty in using TMS to stimulate the leg motor cortical areas. Additionally, leg movements are predominately bilaterally controlled and require interlimb coordination that may involve both hemispheres. The sensitive, but invasive, tools used in animal models of locomotion hold great potential for increasing our understanding of the bihemispheric motor cortical control of walking. In this review, we discuss 3 themes associated with the bihemispheric motor cortical control of walking after stroke: (a) what is known about the role of the bihemispheric motor cortical control in healthy and poststroke leg movements, (b) how the neural remodeling of the contralesional hemisphere can affect walking recovery after a stroke, and (c) what is the effect of behavioral rehabilitation training of walking on the neural remodeling of the motor cortical areas bilaterally. For each theme, we discuss how rodent models can enhance the present knowledge on human walking by testing hypotheses that cannot be investigated in humans, and how these findings can then be back-translated into the neurorehabilitation of poststroke walking.

  2. El neoconstitucionalismo y el nuevo constitucionalismo latinoamericano: ¿dos corrientes llamadas a entenderse? || Neoconstitutionalism And The "New" Latin American Constitutionalism: Two Current Calls To Understand?

    Directory of Open Access Journals (Sweden)

    Nuria Belloso Martin

    2015-12-01

    Full Text Available Resumen: Entre las corrientes del neoconstitucionalismo y del nuevo constitucionalismo latinoamericano hay aspectos que las diferencian pero también un sustrato común, lo que permite sostener la posibilidad de un diálogo fructífero entre ambas corrientes. Lo “nuevo” del nuevo constitucionalismo latinoamericano no es lo nuevo del movimiento constitucional de Latinoamérica. Se analizarán los presupuestos, las líneas de análisis y las posiciones doctrinales sobre el nuevo constitucionalismo latinoamericano, a la vez que se destacarán las peculiaridades que lo caracterizan. Se identificarán los rasgos principales que caracterizan a una y otra corriente, tales como la omnipresencia de la Constitución, el protagonismo de los principios y el renovado papel asignado al Poder Judicial.Abstract: Among neoconstitutionalism currents and the new Latin American constitutionalism are aspects that differentiate but also a common substrate, allowing the possibility to hold a fruitful dialogue between the two currents. The main features that characterize and over current, such as the omnipresence of the Constitution, the role of the principles and the new role assigned to the judiciary be identified. The 'new' Latin American constitutionalism is not new constitutional movement in Latin America. Budgets, the lines of analysis and doctrinal positions on the new Latin American constitutionalism is analyzed, as well as the peculiarities that characterize it will be highlighted. Finally, it asks whether there is anything really "new" in the new Latin American constitutionalism.

  3. A review of the irradiation evolution of dispersed oxide nanoparticles in the b.c.c. Fe-Cr system: Current understanding and future directions

    Science.gov (United States)

    Wharry, Janelle P.; Swenson, Matthew J.; Yano, Kayla H.

    2017-04-01

    Thus far, a number of studies have investigated the irradiation evolution of oxide nanoparticles in b.c.c. Fe-Cr based oxide dispersion strengthened (ODS) alloys. But given the inconsistent experimental conditions, results have been widely variable and inconclusive. Crystal structure and chemistry changes differ from experiment to experiment, and the total nanoparticle volume fraction has been observed to both increase and decrease. Furthermore, there has not yet been a comprehensive review of the archival literature. In this paper, we summarize the existing studies on nanoparticle irradiation evolution. We note significant observations with respect to oxide nanoparticle crystallinity, composition, size, and number density. We discuss four possible contributing mechanisms for nanoparticle evolution: ballistic dissolution, Ostwald ripening, irradiation-enhanced diffusion, and homogeneous nucleation. Finally, we propose future directions to achieve a more comprehensive understanding of irradiation effects on oxide nanoparticles in ODS alloys.

  4. Evaluating simplistic methods to understand current distributions and forecast distribution changes under climate change scenarios: An example with coypu (Myocastor coypus)

    Science.gov (United States)

    Jarnevich, Catherine S.; Young, Nicholas E; Sheffels, Trevor R.; Carter, Jacoby; Systma, Mark D.; Talbert, Colin

    2017-01-01

    Invasive species provide a unique opportunity to evaluate factors controlling biogeographic distributions; we can consider introduction success as an experiment testing suitability of environmental conditions. Predicting potential distributions of spreading species is not easy, and forecasting potential distributions with changing climate is even more difficult. Using the globally invasive coypu (Myocastor coypus [Molina, 1782]), we evaluate and compare the utility of a simplistic ecophysiological based model and a correlative model to predict current and future distribution. The ecophysiological model was based on winter temperature relationships with nutria survival. We developed correlative statistical models using the Software for Assisted Habitat Modeling and biologically relevant climate data with a global extent. We applied the ecophysiological based model to several global circulation model (GCM) predictions for mid-century. We used global coypu introduction data to evaluate these models and to explore a hypothesized physiological limitation, finding general agreement with known coypu distribution locally and globally and support for an upper thermal tolerance threshold. Global circulation model based model results showed variability in coypu predicted distribution among GCMs, but had general agreement of increasing suitable area in the USA. Our methods highlighted the dynamic nature of the edges of the coypu distribution due to climate non-equilibrium, and uncertainty associated with forecasting future distributions. Areas deemed suitable habitat, especially those on the edge of the current known range, could be used for early detection of the spread of coypu populations for management purposes. Combining approaches can be beneficial to predicting potential distributions of invasive species now and in the future and in exploring hypotheses of factors controlling distributions.

  5. Evaluating simplistic methods to understand current distributions and forecast distribution changes under climate change scenarios: an example with coypu (Myocastor coypus

    Directory of Open Access Journals (Sweden)

    Catherine S. Jarnevich

    2017-01-01

    Full Text Available Invasive species provide a unique opportunity to evaluate factors controlling biogeographic distributions; we can consider introduction success as an experiment testing suitability of environmental conditions. Predicting potential distributions of spreading species is not easy, and forecasting potential distributions with changing climate is even more difficult. Using the globally invasive coypu (Myocastor coypus [Molina, 1782], we evaluate and compare the utility of a simplistic ecophysiological based model and a correlative model to predict current and future distribution. The ecophysiological model was based on winter temperature relationships with nutria survival. We developed correlative statistical models using the Software for Assisted Habitat Modeling and biologically relevant climate data with a global extent. We applied the ecophysiological based model to several global circulation model (GCM predictions for mid-century. We used global coypu introduction data to evaluate these models and to explore a hypothesized physiological limitation, finding general agreement with known coypu distribution locally and globally and support for an upper thermal tolerance threshold. Global circulation model based model results showed variability in coypu predicted distribution among GCMs, but had general agreement of increasing suitable area in the USA. Our methods highlighted the dynamic nature of the edges of the coypu distribution due to climate non-equilibrium, and uncertainty associated with forecasting future distributions. Areas deemed suitable habitat, especially those on the edge of the current known range, could be used for early detection of the spread of coypu populations for management purposes. Combining approaches can be beneficial to predicting potential distributions of invasive species now and in the future and in exploring hypotheses of factors controlling distributions.

  6. Enhancing business intelligence by means of suggestive reviews.

    Science.gov (United States)

    Qazi, Atika; Raj, Ram Gopal; Tahir, Muhammad; Cambria, Erik; Syed, Karim Bux Shah

    2014-01-01

    Appropriate identification and classification of online reviews to satisfy the needs of current and potential users pose a critical challenge for the business environment. This paper focuses on a specific kind of reviews: the suggestive type. Suggestions have a significant influence on both consumers' choices and designers' understanding and, hence, they are key for tasks such as brand positioning and social media marketing. The proposed approach consists of three main steps: (1) classify comparative and suggestive sentences; (2) categorize suggestive sentences into different types, either explicit or implicit locutions; (3) perform sentiment analysis on the classified reviews. A range of supervised machine learning approaches and feature sets are evaluated to tackle the problem of suggestive opinion mining. Experimental results for all three tasks are obtained on a dataset of mobile phone reviews and demonstrate that extending a bag-of-words representation with suggestive and comparative patterns is ideal for distinguishing suggestive sentences. In particular, it is observed that classifying suggestive sentences into implicit and explicit locutions works best when using a mixed sequential rule feature representation. Sentiment analysis achieves maximum performance when employing additional preprocessing in the form of negation handling and target masking, combined with sentiment lexicons.

  7. Enhancing Business Intelligence by Means of Suggestive Reviews

    Science.gov (United States)

    Qazi, Atika

    2014-01-01

    Appropriate identification and classification of online reviews to satisfy the needs of current and potential users pose a critical challenge for the business environment. This paper focuses on a specific kind of reviews: the suggestive type. Suggestions have a significant influence on both consumers' choices and designers' understanding and, hence, they are key for tasks such as brand positioning and social media marketing. The proposed approach consists of three main steps: (1) classify comparative and suggestive sentences; (2) categorize suggestive sentences into different types, either explicit or implicit locutions; (3) perform sentiment analysis on the classified reviews. A range of supervised machine learning approaches and feature sets are evaluated to tackle the problem of suggestive opinion mining. Experimental results for all three tasks are obtained on a dataset of mobile phone reviews and demonstrate that extending a bag-of-words representation with suggestive and comparative patterns is ideal for distinguishing suggestive sentences. In particular, it is observed that classifying suggestive sentences into implicit and explicit locutions works best when using a mixed sequential rule feature representation. Sentiment analysis achieves maximum performance when employing additional preprocessing in the form of negation handling and target masking, combined with sentiment lexicons. PMID:25054188

  8. Enhancing Business Intelligence by Means of Suggestive Reviews

    Directory of Open Access Journals (Sweden)

    Atika Qazi

    2014-01-01

    Full Text Available Appropriate identification and classification of online reviews to satisfy the needs of current and potential users pose a critical challenge for the business environment. This paper focuses on a specific kind of reviews: the suggestive type. Suggestions have a significant influence on both consumers’ choices and designers’ understanding and, hence, they are key for tasks such as brand positioning and social media marketing. The proposed approach consists of three main steps: (1 classify comparative and suggestive sentences; (2 categorize suggestive sentences into different types, either explicit or implicit locutions; (3 perform sentiment analysis on the classified reviews. A range of supervised machine learning approaches and feature sets are evaluated to tackle the problem of suggestive opinion mining. Experimental results for all three tasks are obtained on a dataset of mobile phone reviews and demonstrate that extending a bag-of-words representation with suggestive and comparative patterns is ideal for distinguishing suggestive sentences. In particular, it is observed that classifying suggestive sentences into implicit and explicit locutions works best when using a mixed sequential rule feature representation. Sentiment analysis achieves maximum performance when employing additional preprocessing in the form of negation handling and target masking, combined with sentiment lexicons.

  9. Case study of quasi-steady reconnection in Saturn's magnetotail, and update on our current understanding of mass transport and loss in Saturn's nightside magnetosphere

    Science.gov (United States)

    Jackman, C. M.; Thomsen, M. F.; Mitchell, D. G.; Sergis, N.; Arridge, C. S.; Felici, M.; Badman, S. V.; Paranicas, C.; Jia, X.; Hospodarsky, G. B.; Andriopoulou, M.; Khurana, K. K.; Smith, A. W.; Dougherty, M. K.

    2015-10-01

    We present a case study of an event from August20th (day 232) of 2006, as viewed by magnetic field, plasma, energetic particle and plasma wave sensors (MAG/CAPS/MIMI/RPWS) when the Cassini spacecraft was sampling the region near 32 Rs and 22 hours LT in Saturn's magnetotail. Cassini observed a strong northward-to-southward turning of the magnetic field, which is interpreted as the signature of dipolarization of the field as seen by the spacecraft planetward of the reconnection x-line. This event was accompanied by very rapid (up to ~1500 km s-1) thermal plasma flow toward the planet. At energies above 28 keV, energetic hydrogen and oxygen ion flow bursts were observed to stream planetward from a reconnection site downtail of the spacecraft. Meanwhile a strong field-aligned beam of energetic hydrogen was also observed to stream tailward, likely from an ionospheric source. Saturn Kilometric Radiation emissions were stimulated shortly after the observation of the dipolarization. We discuss the field, plasma, energetic particle and radio observations in the context of the impact this reconnection event had on global magnetospheric dynamics.We also discuss this event in terms of other recent studies of reconnection in Saturn's tail and update on the emerging picture concerning our understanding of how mass is transported and lost within Saturn's magnetosphere.

  10. Integrating Composition and Literature: Some Practical Suggestions.

    Science.gov (United States)

    Daiker, Donald A.

    This paper suggests that it is possible to construct a course that integrates the teaching of composition with the teaching of literature without allowing the secondary goal of heightened literary understanding to overwhelm the primary goal of improved expository writing. It presents a syllabus for a four-week unit on Ernest Hemingway's "The Sun…

  11. Deepening Sleep by Hypnotic Suggestion

    Science.gov (United States)

    Cordi, Maren J.; Schlarb, Angelika A.; Rasch, Björn

    2014-01-01

    Study Objectives: Slow wave sleep (SWS) plays a critical role in body restoration and promotes brain plasticity; however, it markedly declines across the lifespan. Despite its importance, effective tools to increase SWS are rare. Here we tested whether a hypnotic suggestion to “sleep deeper” extends the amount of SWS. Design: Within-subject, placebo-controlled crossover design. Setting: Sleep laboratory at the University of Zurich, Switzerland. Participants: Seventy healthy females 23.27 ± 3.17 y. Intervention: Participants listened to an auditory text with hypnotic suggestions or a control tape before napping for 90 min while high-density electroencephalography was recorded. Measurements and Results: After participants listened to the hypnotic suggestion to “sleep deeper” subsequent SWS was increased by 81% and time spent awake was reduced by 67% (with the amount of SWS or wake in the control condition set to 100%). Other sleep stages remained unaffected. Additionally, slow wave activity was significantly enhanced after hypnotic suggestions. During the hypnotic tape, parietal theta power increases predicted the hypnosis-induced extension of SWS. Additional experiments confirmed that the beneficial effect of hypnotic suggestions on SWS was specific to the hypnotic suggestion and did not occur in low suggestible participants. Conclusions: Our results demonstrate the effectiveness of hypnotic suggestions to specifically increase the amount and duration of slow wave sleep (SWS) in a midday nap using objective measures of sleep in young, healthy, suggestible females. Hypnotic suggestions might be a successful tool with a lower risk of adverse side effects than pharmacological treatments to extend SWS also in clinical and elderly populations. Citation: Cordi MJ, Schlarb AA, Rasch B. Deepening sleep by hypnotic suggestion. SLEEP 2014;37(6):1143-1152. PMID:24882909

  12. Suggestions on Training MTI Translators and Interpreters

    Institute of Scientific and Technical Information of China (English)

    徐岩

    2013-01-01

    This article gives a brief review of the current state of training MTI translators and interpreters.After analyzing the problems that exist in course of the training,the author,as a student of MTI,puts forth some suggestions to improve the MTI training in colleges and universities to train practical translators and interpreters from the point of view of learning.

  13. Cable Television Report and Suggested Ordinance.

    Science.gov (United States)

    League of California Cities, Sacramento.

    Guidelines and suggested ordinances for cable television regulation by local governments are comprehensively discussed in this report. The emphasis is placed on franchising the cable operator. Seventeen legal aspects of franchising are reviewed, and an exemplary ordinance is presented. In addition, current statistics about cable franchising in…

  14. Leadership Theories--Managing Practices, Challenges, Suggestions

    Science.gov (United States)

    Hawkins, Cheryl

    2009-01-01

    A shortage of community college executives due to the number of retirements occurring among current leaders is predicted. An examination of three leadership theories--servant-leadership, business leadership and transformational leadership--suggests techniques for potential community college leaders. Servant-leaders focus on the needs of their…

  15. [Suggestion and hypnosis in hysteria].

    Science.gov (United States)

    Berner, P

    1995-12-15

    Suggestive influences allow to resolve ambiguities. Normally they are only accepted if they correspond with the knowledge and believes of the subject. Under hypnosis or under the impact of serious psychic perturbations one may take up reality constructions which are not in conformity with these criteria. The restriction of consciousness and the ignoring of certain functions permitting this are the common basis of hypnosis and hysteria. But suggestions do not cause the later; they may only shape the symptomatology. Hypnosis can create a terrain facilitating the resolution of the problems underlying hysteria but it does not represent the treatment of hysteria.

  16. Current Understanding of Psychosis in Parkinson's Disease.

    Science.gov (United States)

    Ojo, Oluwadamilola O; Fernandez, Hubert H

    2016-10-01

    Psychosis in Parkinson's disease (PD) is one of the greatest determinants of nursing home placement and caregiver stress. Traditionally associated with medications with dopaminergic effect, it has now been linked to other medications and other stressors e.g. systemic illnesses. The development of hallucinations in a PD patient can herald the onset of dementia and usually predicts increased mortality risk. Medication reduction in PD psychosis usually reduces the symptoms; however, this comes at the cost of worsening motor function. If gradually decreasing the patient's medications does not resolve the psychosis, the treatment of choice is an atypical antipychotic. Though only clozapine has level A recommendation for this indication, other atypicals like quetiapine continue to get used for this purpose on account of the logistics involved with clozapine use. Cholinesterase inhibitors are also increasingly being used for PD psychosis on account of the association with dementia. The treatment of PD psychosis is an unmet need in PD management and search for suitable agents constitutes an active area of research in PD.

  17. Secondary Amenorrhea among Female Athletes. Current Understandings.

    Science.gov (United States)

    Sasiene, Gwen Hagenbuch

    1983-01-01

    Research pertaining to female athletes' problems with secondary amenorrhea is reviewed. Studies point to stress, weight loss, anorexia nervosa, obesity, arduous athletic training, and age of onset of training as factors which may contribute to this disorder. (PP)

  18. Current understanding of multi-species biofilms

    DEFF Research Database (Denmark)

    Yang, Liang; Liu, Yang; Wu, Hong

    2011-01-01

    Direct observation of a wide range of natural microorganisms has revealed the fact that the majority of microbes persist as surface-attached communities surrounded by matrix materials, called biofilms. Biofilms can be formed by a single bacterial strain. However, most natural biofilms are actuall...

  19. Current Understanding of Perfluoroalkyl Acid Toxicology

    Science.gov (United States)

    The perfluoroalkyl acids (PFAAs) are a family of organic chemicals consisting of a perfluorinated carbon backbone (4-14 carbons in length) and an anionic head group (sulfonate, carboxylate or phosphonate). These compounds have excellent surface-tension reducing properties and hav...

  20. Understanding ionospheric instabilities eludes current approaches

    Science.gov (United States)

    Bhattacharya, Atreyee

    2012-07-01

    Ionized gases are heavily concentrated in the ionosphere's F zone, the region between 200 and 500 kilometers in altitude, which is critical for transmitting long-distance radio signals on Earth. However, instabilities in the F region plasma, which can last from seconds to hours and can be spread over centimeters to tens of kilometers, disrupt transmission of radio signals. The plasma instabilities, restricted to the equatorial region following sunset, are called equatorial spread F (ESF). Earth-based instruments perceive ESF events as “twinkling” radio signals. ESF events, first detected in the 1930s, affect the performance and reliability of space-borne and ground-based electronic systems; they can disrupt satellite operations and related communications and navigation systems.

  1. Current understanding of multi-species biofilms

    DEFF Research Database (Denmark)

    Yang, Liang; Liu, Yang; Wu, Hong

    2011-01-01

    Direct observation of a wide range of natural microorganisms has revealed the fact that the majority of microbes persist as surface-attached communities surrounded by matrix materials, called biofilms. Biofilms can be formed by a single bacterial strain. However, most natural biofilms are actuall...

  2. Suggestions on photons and fermions

    CERN Document Server

    Alvargonzalez, R

    2007-01-01

    In this paper we suggest a configuration of photons consistent with a spin $\\hbar$, and a configuration of the fermions coherent with a spin $\\hbar/2$. These suggested configurations open the way to further analyses which lead to the following conclusions: - There cannot exist elementary particles of spin $\\hbar/2$ with a mass inferior to $1m_e$ or with a radius greater than $1l_e$. - The electrostatic force derives from the centrifugal forces inherent to the spin and are propagated by photons. - The derivation of the electrostatic force explains the existence of positive and negative charges and Coulomb's law. - The enormous differences between the centrifugal forces and the centripetal forces at the surface of the protons give rise to quantic fluctuations of space which generate the energy flows necessary for equilibrium. These energy flows can explain gravitation and the strong force. - The mass of the proton, $m_p$, and the mass of the neutron, $m_n$, must each have a concrete value required for the cohes...

  3. A reassessment of the potential for an alpha-mode containment failure and a review of the current understanding of broader fuel-coolant interaction issues. Second steam explosion review group workshop

    Energy Technology Data Exchange (ETDEWEB)

    Basu, S. [Nuclear Regulatory Commission, Washington, DC (United States); Ginsberg, T. [Brookhaven National Lab., Upton, NY (United States)

    1996-08-01

    This report summarizes the review and evaluation by experts of the current understanding of the molten fuel-coolant interaction (FCI) issues covering the complete spectrum of interactions, i.e., from mild quenching to very energetic interactions including those that could lead to the alpha-mode containment failure. Of the eleven experts polled, all but two concluded that the alpha-mode failure issue was resolved from a risk perspective, meaning that this mode of failure is of very low probability, that it is of little or no significance to the overall risk from a nuclear power plant, and that any further reduction in residual uncertainties is not likely to change the probability in an appreciable manner. To a lesser degree, discussions also took place on the broader FCI issues such as mild quenching of core melt during non-explosive FCI, and shock loading of lower head and ex-vessel support structures arising from explosive localized FCIs. These latter issues are relevant with regard to determining the efficacy of certain accident management strategies for operating reactors as well as for advanced light water reactors. The experts reviewed the status of understanding of the FCI phenomena in the context of these broader issues, identified residual uncertainties in the understanding, and recommended future research (both experimental and analytical) to reduce the uncertainties.

  4. Understanding Dyslexia

    Science.gov (United States)

    ... Surgery? A Week of Healthy Breakfasts Shyness Understanding Dyslexia KidsHealth > For Teens > Understanding Dyslexia A A A ... realize is that Sarah has dyslexia. What Is Dyslexia? Dyslexia (pronounced: dis-LEK-see-uh) is a ...

  5. Understanding Dyslexia

    Science.gov (United States)

    ... Surgery? A Week of Healthy Breakfasts Shyness Understanding Dyslexia KidsHealth > For Teens > Understanding Dyslexia Print A A ... realize is that Sarah has dyslexia. What Is Dyslexia? Dyslexia (pronounced: dis-LEK-see-uh) is a ...

  6. The functional anatomy of suggested limb paralysis.

    Science.gov (United States)

    Deeley, Quinton; Oakley, David A; Toone, Brian; Bell, Vaughan; Walsh, Eamonn; Marquand, Andre F; Giampietro, Vincent; Brammer, Michael J; Williams, Steven C R; Mehta, Mitul A; Halligan, Peter W

    2013-02-01

    Suggestions of limb paralysis in highly hypnotically suggestible subjects have been employed to successfully model conversion disorders, revealing similar patterns of brain activation associated with attempted movement of the affected limb. However, previous studies differ with regard to the executive regions involved during involuntary inhibition of the affected limb. This difference may have arisen as previous studies did not control for differences in hypnosis depth between conditions and/or include subjective measures to explore the experience of suggested paralysis. In the current study we employed functional magnetic resonance imaging (fMRI) to examine the functional anatomy of left and right upper limb movements in eight healthy subjects selected for high hypnotic suggestibility during (i) hypnosis (NORMAL) and (ii) attempted movement following additional left upper limb paralysis suggestions (PARALYSIS). Contrast of left upper limb motor function during NORMAL relative to PARALYSIS conditions revealed greater activation of contralateral M1/S1 and ipsilateral cerebellum, consistent with the engagement of these regions in the completion of movements. By contrast, two significant observations were noted in PARALYSIS relative to NORMAL conditions. In conjunction with reports of attempts to move the paralysed limb, greater supplementary motor area (SMA) activation was observed, a finding consistent with the role of SMA in motor intention and planning. The anterior cingulate cortex (ACC, BA 24) was also significantly more active in PARALYSIS relative to NORMAL conditions - suggesting that ACC (BA 24) may be implicated in involuntary, as well as voluntary inhibition of prepotent motor responses.

  7. Understanding Medical Words

    Science.gov (United States)

    ... Bar Home Current Issue Past Issues Understanding Medical Words Past Issues / Summer 2009 Table of Contents For ... Medicine that teaches you about many of the words related to your health care Do you have ...

  8. Embodied understanding.

    Science.gov (United States)

    Johnson, Mark

    2015-01-01

    Western culture has inherited a view of understanding as an intellectual cognitive operation of grasping of concepts and their relations. However, cognitive science research has shown that this received intellectualist conception is substantially out of touch with how humans actually make and experience meaning. The view emerging from the mind sciences recognizes that understanding is profoundly embodied, insofar as our conceptualization and reasoning recruit sensory, motor, and affective patterns and processes to structure our understanding of, and engagement with, our world. A psychologically realistic account of understanding must begin with the patterns of ongoing interaction between an organism and its physical and cultural environments and must include both our emotional responses to changes in our body and environment, and also the actions by which we continuously transform our experience. Consequently, embodied understanding is not merely a conceptual/propositional activity of thought, but rather constitutes our most basic way of being in, and engaging with, our surroundings in a deep visceral manner.

  9. Understanding Chemotherapy

    Science.gov (United States)

    N ational C ancer I nstitute Understanding Chemotherapy What is chemotherapy? Chemotherapy is a cancer treatment that uses drugs to destroy cancer cells. It is also called “chemo.” Today, there are ...

  10. Understanding Translation

    DEFF Research Database (Denmark)

    Schjoldager, Anne Gram; Gottlieb, Henrik; Klitgård, Ida

    Understanding Translation is designed as a textbook for courses on the theory and practice of translation in general and of particular types of translation - such as interpreting, screen translation and literary translation. The aim of the book is to help you gain an in-depth understanding...... - translators, language teachers, translation users and literary, TV and film critics, for instance. Discussions focus on translation between Danish and English....

  11. Understanding semantics

    DEFF Research Database (Denmark)

    Thrane, Torben

    1997-01-01

    Understanding natural language is a cognitive, information-driven process. Discussing some of the consequences of this fact, the paper offers a novel look at the semantic effect of lexical nouns and the identification of reference types.......Understanding natural language is a cognitive, information-driven process. Discussing some of the consequences of this fact, the paper offers a novel look at the semantic effect of lexical nouns and the identification of reference types....

  12. Understanding Translation

    DEFF Research Database (Denmark)

    Schjoldager, Anne Gram; Gottlieb, Henrik; Klitgård, Ida

    Understanding Translation is designed as a textbook for courses on the theory and practice of translation in general and of particular types of translation - such as interpreting, screen translation and literary translation. The aim of the book is to help you gain an in-depth understanding of the...... - translators, language teachers, translation users and literary, TV and film critics, for instance. Discussions focus on translation between Danish and English....

  13. The current situation, problems and suggestions for logistical support of geological exploration units'field work in China%我国地勘单位野外地质工作后勤保障现状、问题与建议

    Institute of Scientific and Technical Information of China (English)

    方敏; 周海东; 王雪; 李虹

    2015-01-01

    This paper studies the logistics support system of field geological work of geological exploration organization in China and mainly analyzes the current status and problems of lodging ,restaurant , medical ,communication ,cultural entertainment and so on .For that purpose ,this paper put forward some suggestions on accelerated advancing standard system ,construction fund guarantee and multi‐level emergency rescue mechanism ,improved health and safety management system of the logistics support system of field geological work .%本文简要论述了我国地勘单位野外地质工作后勤保障制度情况,重点从住宿、餐饮、医疗卫生、通讯、文化娱乐等方面分析了我国地勘单位野外地质工作后勤保障的现状,分析了我国地勘单位野外地质工作后勤保障方面存在的问题,提出了加快推进野外地质工作后勤保障标准体系建设、构建野外地质工作后勤经费保障体系、探索构建野外地质工作事故多级应急救援新机制和完善野外地质工作职业安全健康监督管理体系的政策建议。

  14. On Understanding and Machine Understanding

    CERN Document Server

    Chern, Tong

    2011-01-01

    In the present paper, we try to propose a self-similar network theory for the basic understanding. By extending the natural languages to a kind of so called idealy sufficient language, we can proceed a few steps to the investigation of the language searching and the language understanding of AI. Image understanding, and the familiarity of the brain to the surrounding environment are also discussed. Group effects are discussed by addressing the essense of the power of influences, and constructing the influence network of a society. We also give a discussion of inspirations.

  15. Understanding the Important Role of"Classroom"--On Current Middle School English Teaching Management%认识“课堂”的重要作用--浅议当前中学英语教学管理

    Institute of Scientific and Technical Information of China (English)

    樊碧垠

    2014-01-01

    通常认为“课堂”是指教学场所(教室),其实这是一种狭隘的“课堂”观。“课堂”应是一种情景教育,是师生交往互动的心理空间,是一个师生文化碰撞、对话的社会场所。对“课堂”的重新认识,有助于当前的中学英语教学管理革新,而“课堂设计”的创新,则无疑是新“课堂”观得以实施的重要手段。%Generally consider"classroom"refers to the teaching spaces (classroom), in fact, this is a narrowing"classroom"concept."Classroom"should be a scenario of education, the mental space of teacher-student interaction, is a culture clash of teachers and students, social spaces for dialogue. On the"classroom"of new understanding, to help manage the current high school English teaching reform, and"classroom design"innovation, is undoubtedly an important means of new"classroom"concept to implementation.

  16. Learning from epidemiological, clinical, and immunological studies on Mycobacterium africanum for improving current understanding of host–pathogen interactions, and for the development and evaluation of diagnostics, host-directed therapies, and vaccines for tuberculosis

    Directory of Open Access Journals (Sweden)

    Alimuddin Zumla

    2017-03-01

    Full Text Available Mycobacterium africanum comprises two phylogenetic lineages within the Mycobacterium tuberculosis complex (MTBC. M. africanum was first described and isolated in 1968 from the sputum of a Senegalese patient with pulmonary tuberculosis (TB and it has been identified increasingly as an important cause of human TB, particularly prevalent in West Africa. The restricted geographical distribution of M. africanum, in contrast to the widespread global distribution of other species of MTBC, requires explanation. Available data indicate that M. africanum may also have important differences in transmission, pathogenesis, and host–pathogen interactions, which could affect the evaluation of new TB intervention tools (diagnostics and vaccines–those currently in use and those under development. The unequal geographical distribution and spread of MTBC species means that individual research findings from one country or region cannot be generalized across the continent. Thus, generalizing data from previous and ongoing research studies on MTBC may be inaccurate and inappropriate. A major rethink is required regarding the design and structure of future clinical trials of new interventions. The West, Central, East, and Southern African EDCTP Networks of Excellence provide opportunities to take forward these pan-Africa studies. More investments into molecular, epidemiological, clinical, diagnostic, and immunological studies across the African continent are required to enable further understanding of host–M. africanum interactions, leading to the development of more specific diagnostics, biomarkers, host-directed therapies, and vaccines for TB.

  17. Learning from epidemiological, clinical, and immunological studies on Mycobacterium africanum for improving current understanding of host-pathogen interactions, and for the development and evaluation of diagnostics, host-directed therapies, and vaccines for tuberculosis.

    Science.gov (United States)

    Zumla, Alimuddin; Otchere, Isaac Darko; Mensah, Gloria Ivy; Asante-Poku, Adwoa; Gehre, Florian; Maeurer, Markus; Bates, Matthew; Mwaba, Peter; Ntoumi, Francine; Yeboah-Manu, Dorothy

    2017-03-01

    Mycobacterium africanum comprises two phylogenetic lineages within the Mycobacterium tuberculosis complex (MTBC). M. africanum was first described and isolated in 1968 from the sputum of a Senegalese patient with pulmonary tuberculosis (TB) and it has been identified increasingly as an important cause of human TB, particularly prevalent in West Africa. The restricted geographical distribution of M. africanum, in contrast to the widespread global distribution of other species of MTBC, requires explanation. Available data indicate that M. africanum may also have important differences in transmission, pathogenesis, and host-pathogen interactions, which could affect the evaluation of new TB intervention tools (diagnostics and vaccines)-those currently in use and those under development. The unequal geographical distribution and spread of MTBC species means that individual research findings from one country or region cannot be generalized across the continent. Thus, generalizing data from previous and ongoing research studies on MTBC may be inaccurate and inappropriate. A major rethink is required regarding the design and structure of future clinical trials of new interventions. The West, Central, East, and Southern African EDCTP Networks of Excellence provide opportunities to take forward these pan-Africa studies. More investments into molecular, epidemiological, clinical, diagnostic, and immunological studies across the African continent are required to enable further understanding of host-M. africanum interactions, leading to the development of more specific diagnostics, biomarkers, host-directed therapies, and vaccines for TB. Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  18. Embodied Understanding

    Directory of Open Access Journals (Sweden)

    Mark Leonard Johnson

    2015-06-01

    Full Text Available Western culture has inherited a view of understanding as an intellectual cognitive operation of grasping of concepts and their relations. However, cognitive science research has shown that this received intellectualist conception is substantially out of touch with how humans actually make and experience meaning. The view emerging from the mind sciences recognizes that understanding is profoundly embodied, insofar as our conceptualization and reasoning recruit sensory, motor, and affective patterns and processes to structure our understanding of, and engagement with, our world. A psychologically realistic account of understanding must begin with the patterns of ongoing interaction between an organism and its physical and cultural environments and must include both our emotional responses to changes in our body and environment, and also the actions by which we continuously transform our experience. Consequently, embodied understanding is not merely a conceptual/propositional activity of thought, but rather constitutes our most basic way of being in, and engaging with, our surroundings in a deep visceral manner.

  19. TEACHING READING:PROBLEMS AND SUGGESTIONS

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    IntroductionAmong the four skills,reading has been viewed as the most basic and useful skill for Chinese learners ofEnglish.Many college students will.after leaving their English class,come into contact largely(andsometimes solely)with the written form of the language.Therefore the instruction of reading has becomevery important in English teaching Although great developments have been made both in the linguisticand pragmatic fields of reading analysis.teaching Chinese students the specific skills of reading inEnglish is still a tough problem.Many English teachers have become more and more aware of theChinese students difficulties and more and more aware of how inefficient the traditional approach is inthe design of teaching materials and leaching methods.As a result,this paper is an attempt to analysesome current theoretical achievements and suggest a revised method for teaching Chinese students.

  20. Understanding Maple

    CERN Document Server

    Thompson, Ian

    2016-01-01

    Maple is a powerful symbolic computation system that is widely used in universities around the world. This short introduction gives readers an insight into the rules that control how the system works, and how to understand, fix, and avoid common problems. Topics covered include algebra, calculus, linear algebra, graphics, programming, and procedures. Each chapter contains numerous illustrative examples, using mathematics that does not extend beyond first-year undergraduate material. Maple worksheets containing these examples are available for download from the author's personal website. The book is suitable for new users, but where advanced topics are central to understanding Maple they are tackled head-on. Many concepts which are absent from introductory books and manuals are described in detail. With this book, students, teachers and researchers will gain a solid understanding of Maple and how to use it to solve complex mathematical problems in a simple and efficient way.

  1. Understanding physics

    CERN Document Server

    Mansfield, Michael

    2011-01-01

    Understanding Physics - Second edition is a comprehensive, yet compact, introductory physics textbook aimed at physics undergraduates and also at engineers and other scientists taking a general physics course. Written with today's students in mind, this text covers the core material required by an introductory course in a clear and refreshing way. A second colour is used throughout to enhance learning and understanding. Each topic is introduced from first principles so that the text is suitable for students without a prior background in physics. At the same time the book is designed to enable

  2. Current interruption transients calculation

    CERN Document Server

    Peelo, David F

    2014-01-01

    Provides an original, detailed and practical description of current interruption transients, origins, and the circuits involved, and how they can be calculated Current Interruption Transients Calculationis a comprehensive resource for the understanding, calculation and analysis of the transient recovery voltages (TRVs) and related re-ignition or re-striking transients associated with fault current interruption and the switching of inductive and capacitive load currents in circuits. This book provides an original, detailed and practical description of current interruption transients, origins,

  3. Dinosaur Peptides Suggest Mechanisms of Protein Survival

    Energy Technology Data Exchange (ETDEWEB)

    San Antonio, James D.; Schweitzer, Mary H.; Jensen, Shane T.; Kalluri, Raghu; Buckley, Michael; Orgel, Joseph P.R.O. (Harvard-Med); (IIT); (NCSU); (UPENN); (Manchester); (Orthovita)

    2011-09-16

    Eleven collagen peptide sequences recovered from chemical extracts of dinosaur bones were mapped onto molecular models of the vertebrate collagen fibril derived from extant taxa. The dinosaur peptides localized to fibril regions protected by the close packing of collagen molecules, and contained few acidic amino acids. Four peptides mapped to collagen regions crucial for cell-collagen interactions and tissue development. Dinosaur peptides were not represented in more exposed parts of the collagen fibril or regions mediating intermolecular cross-linking. Thus functionally significant regions of collagen fibrils that are physically shielded within the fibril may be preferentially preserved in fossils. These results show empirically that structure-function relationships at the molecular level could contribute to selective preservation in fossilized vertebrate remains across geological time, suggest a 'preservation motif', and bolster current concepts linking collagen structure to biological function. This non-random distribution supports the hypothesis that the peptides are produced by the extinct organisms and suggests a chemical mechanism for survival.

  4. Understanding Energy

    Science.gov (United States)

    Menon, Deepika; Shelby, Blake; Mattingly, Christine

    2016-01-01

    "Energy" is a term often used in everyday language. Even young children associate energy with the food they eat, feeling tired after playing soccer, or when asked to turn the lights off to save light energy. However, they may not have the scientific conceptual understanding of energy at this age. Teaching energy and matter could be…

  5. Understanding Carbohydrates

    Science.gov (United States)

    ... Starchy Vegetables Fats Alcohol What Can I Drink? Fruit Dairy Food Tips Eating Out Quick Meal Ideas Snacks Nutrient Content Claims Understanding Carbohydrates Types of Carbohydrates Carbohydrate Counting Make Your Carbs Count Glycemic Index Low-Calorie Sweeteners Sugar and Desserts Fitness Exercise & ...

  6. Analysis of the Current Pebrine Sampling Inspection of Mother Moth for F1 Hybrid with Hypergeometric Distri-bution Model and Suggest Improvement%现行一代杂交种母蛾微粒子病抽样检验方案的特点及改进意见

    Institute of Scientific and Technical Information of China (English)

    汤庆坤; 何国玲; 黄旭华; 胡文娟; 韦廷秀; 黄景滩

    2014-01-01

    Analyzed on the characteristics of the current pebrine inspection of mother moth of F1 Hybrid, and proposed some suggest improvements about the pebrine inspection of mother moth of F1 Hybrid which suit for the silkworm eggs on card.Used the hypergeometric distribution as the basic mathematical model, to make compara-tive analysis of the current pebrine inspection of mother moth of F1 Hybrid with sampling inspection principle. There are some advantages for agricultural industry standard of silkworm loose eggs that the unqualified batch are rejected with high probability and less inspection works, but it also has some disadvantages that the qualified batch are rejected with high probability, the risk of manufacturer are great. Another standard is agricultural in-dustry standard of silkworm eggs on card, it has some advantages, including that the sampling are simple and practicable, the sample are typical, the unit is unified, the unqualified batch of silkworm eggs are rejected in the right number, and there also are some disadvantages that the inspection probability has no guarantee, the probability of “two types of errors” are coexist, workload of inspection are heavy. The regional industry standard of Guangxi has the features of agricultural industry standard of silkworm loose eggs, but also has some disadvantages that the implementation of standard is not asymmetric, the sample is not typical and the risk of manufacturer is further increased. Therefore, we put forward a fitting scheme and suggestions for actual produc-tion of silkworm eggs on card, including that stratified sampling, testing two times, controlled inspection risk, increased individual number in sampling group, groups as unit and the 1% index of percentage of dis-eased moths, etc.%分析现行桑蚕一代杂交种母蛾微粒子病检验方案的特点,提出适合平附种的母蛾微粒子病检验方案的改进意见。以超几何分布为基本数学模型,从抽样检验原理对桑

  7. 铁过载对骨髓增生异常综合征患者不良危害若干问题的认识%Current Understanding of Iron Overload Hazard in Patients with Myelodysplastic Syndrome-Review

    Institute of Scientific and Technical Information of China (English)

    宋陆茜; 苏基滢; 张征; 常春康

    2013-01-01

    骨髓增生异常综合征(myelodysplastic syndromes,MDS)患者自然病程中会出现输血依赖并发展为输血相关的铁过载,同时由于MDS红细胞无效造血,肠道加强膳食铁的吸收而加重铁过载.铁过载与MDS并发症、降低MDS生存期密切相关.因此,本文将阐述MDS输血依赖及铁过载的认识,特别关注作为不稳定铁的氧化还原活性存在形式的作用机制、铁过载通过氧化应激对MDS造血机能影响的机制及对MDS生存期及白血病转化风险的影响等问题.%Patients with myelodysplastic syndromes (MDS) become dependent on blood transfusions and develop into transfusional iron overload, which is exacerbated by increased absorption of dietary iron in response to ineffective erythropoiesis. However, it is uncertain whether there is an association among iron accumulation, clinical complications, and decreased likelihood of survival in MDS patients. Thereby our current understanding of the effects of transfusion dependency and iron overload in MDS are discussed. Particular emphasis should be placed on further characterizing the role of redox-active forms of labile iron and oxidative stress in iron overload, decreased life expectancy and increased risk of leukemic transformation in MDS patients with iron overload.

  8. Understanding Resilience

    Directory of Open Access Journals (Sweden)

    Gang eWu

    2013-02-01

    Full Text Available Resilience is the ability to adapt successfully in the face of stress and adversity. Stressful life events, trauma and chronic adversity can have a substantial impact on brain function and structure, and can result in the development of PTSD, depression and other psychiatric disorders. However, most individuals do not develop such illnesses after experiencing stressful life events, and are thus thought to be resilient. Resilience as successful adaptation relies on effective responses to environmental challenges and ultimate resistance to the deleterious effects of stress, therefore a greater understanding of the factors that promote such effects is of great relevance. This review focuses on recent findings regarding genetic, epigenetic, developmental, psychosocial and neurochemical factors that are considered essential contributors to the development of resilience. Neural circuits and pathways involved in mediating resilience are also discussed. The growing understanding of resilience factors will hopefully lead to the development of new pharmacological and psychological interventions for enhancing resilience and mitigating the untoward consequences.

  9. Understanding resilience.

    Science.gov (United States)

    Wu, Gang; Feder, Adriana; Cohen, Hagit; Kim, Joanna J; Calderon, Solara; Charney, Dennis S; Mathé, Aleksander A

    2013-01-01

    Resilience is the ability to adapt successfully in the face of stress and adversity. Stressful life events, trauma, and chronic adversity can have a substantial impact on brain function and structure, and can result in the development of posttraumatic stress disorder (PTSD), depression and other psychiatric disorders. However, most individuals do not develop such illnesses after experiencing stressful life events, and are thus thought to be resilient. Resilience as successful adaptation relies on effective responses to environmental challenges and ultimate resistance to the deleterious effects of stress, therefore a greater understanding of the factors that promote such effects is of great relevance. This review focuses on recent findings regarding genetic, epigenetic, developmental, psychosocial, and neurochemical factors that are considered essential contributors to the development of resilience. Neural circuits and pathways involved in mediating resilience are also discussed. The growing understanding of resilience factors will hopefully lead to the development of new pharmacological and psychological interventions for enhancing resilience and mitigating the untoward consequences.

  10. Understanding competitiveness

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard; Rauner, Felix

    1996-01-01

    Conclusion of the book: Industrial cultures and production. Summary of the main positions presented in the different chapters of the bookand a suggestion how to interprete different stages of development in industrial cultures....

  11. Understand electronics

    CERN Document Server

    Bishop, Owen

    2013-01-01

    Understand Electronics provides a readable introduction to the exciting world of electronics for the student or enthusiast with little previous knowledge. The subject is treated with the minimum of mathematics and the book is extensively illustrated.This is an essential guide for the newcomer to electronics, and replaces the author's best-selling Beginner's Guide to Electronics.The step-by-step approach makes this book ideal for introductory courses such as the Intermediate GNVQ.

  12. Understanding users

    DEFF Research Database (Denmark)

    Johannsen, Carl Gustav Viggo

    2014-01-01

    Segmentation of users can help libraries in the process of understanding user similarities and differences. Segmentation can also form the basis for selecting segments of target users and for developing tailored services for specific target segments. Several approaches and techniques have been...... segmentation project using computer-generated clusters. Compared to traditional marketing texts, this article also tries to identify user segments or images or metaphors by the library profession itself....

  13. Understanding Iran

    Science.gov (United States)

    2009-01-01

    national character.” And although national character analysis is out of vogue in the United States, I attribute the use of the term to the...also notable counter-examples of resource benefactions: for example, Norway, Britain , and North Sea oil and gas deposits. 124 Understanding Iran...English, Farsi, Italian, and Spanish. Sadjadpour’s recent commentary, articles, and testimony include “ Britain -Iran Standoff ,” PBS’s Newshour with

  14. Understanding users

    DEFF Research Database (Denmark)

    Johannsen, Carl Gustav Viggo

    2014-01-01

    Segmentation of users can help libraries in the process of understanding user similarities and differences. Segmentation can also form the basis for selecting segments of target users and for developing tailored services for specific target segments. Several approaches and techniques have been te...... segmentation project using computer-generated clusters. Compared to traditional marketing texts, this article also tries to identify user segments or images or metaphors by the library profession itself....

  15. Understanding Sociolinguistics

    Institute of Scientific and Technical Information of China (English)

    胡萍萍

    2003-01-01

    Sociolinguistics has drawn more and more attention since it became an independent discipline in mid 1960s. But scholars from various disciplines look at sociolinguistics from different perspectives, and carry out sociolinguistic study in different ways. This paper tries to understand sociolinguistics in terms of its definitions and the scope of sociolinguistic study to point out the lack of comprehensiveness in Fishman's view on the definition of sociolinguistics.

  16. Testing Understanding and Understanding Testing.

    Science.gov (United States)

    Pedersen, Jean; Ross, Peter

    1985-01-01

    Provides examples in which graphs are used in the statements of problems or in their solutions as a means of testing understanding of mathematical concepts. Examples (appropriate for a beginning course in calculus and analytic geometry) include slopes of lines and curves, quadratic formula, properties of the definite integral, and others. (JN)

  17. Understanding Magnitudes to Understand Fractions

    Science.gov (United States)

    Gabriel, Florence

    2016-01-01

    Fractions are known to be difficult to learn and difficult to teach, yet they are vital for students to have access to further mathematical concepts. This article uses evidence to support teachers employing teaching methods that focus on the conceptual understanding of the magnitude of fractions.

  18. Pattern Genes Suggest Functional Connectivity of Organs

    Science.gov (United States)

    Qin, Yangmei; Pan, Jianbo; Cai, Meichun; Yao, Lixia; Ji, Zhiliang

    2016-05-01

    Human organ, as the basic structural and functional unit in human body, is made of a large community of different cell types that organically bound together. Each organ usually exerts highly specified physiological function; while several related organs work smartly together to perform complicated body functions. In this study, we present a computational effort to understand the roles of genes in building functional connection between organs. More specifically, we mined multiple transcriptome datasets sampled from 36 human organs and tissues, and quantitatively identified 3,149 genes whose expressions showed consensus modularly patterns: specific to one organ/tissue, selectively expressed in several functionally related tissues and ubiquitously expressed. These pattern genes imply intrinsic connections between organs. According to the expression abundance of the 766 selective genes, we consistently cluster the 36 human organs/tissues into seven functional groups: adipose & gland, brain, muscle, immune, metabolism, mucoid and nerve conduction. The organs and tissues in each group either work together to form organ systems or coordinate to perform particular body functions. The particular roles of specific genes and selective genes suggest that they could not only be used to mechanistically explore organ functions, but also be designed for selective biomarkers and therapeutic targets.

  19. Tag Correspondence Model for User Tag Suggestion

    Institute of Scientific and Technical Information of China (English)

    涂存超; 刘知远; 孙茂松

    2015-01-01

    Some microblog services encourage users to annotate themselves with multiple tags, indicating their attributes and interests. User tags play an important role for personalized recommendation and information retrieval. In order to better understand the semantics of user tags, we propose Tag Correspondence Model (TCM) to identify complex correspondences of tags from the rich context of microblog users. The correspondence of a tag is referred to as a unique element in the context which is semantically correlated with this tag. In TCM, we divide the context of a microblog user into various sources (such as short messages, user profile, and neighbors). With a collection of users with annotated tags, TCM can automatically learn the correspondences of user tags from multiple sources. With the learned correspondences, we are able to interpret implicit semantics of tags. Moreover, for the users who have not annotated any tags, TCM can suggest tags according to users’ context information. Extensive experiments on a real-world dataset demonstrate that our method can effciently identify correspondences of tags, which may eventually represent semantic meanings of tags.

  20. Western Australian school students' understanding of biotechnology

    Science.gov (United States)

    Dawson, Vaille; Schibeci, Renato

    2003-01-01

    Are science educators providing secondary school students with the background to understand the science behind recent controversies such as the recently introduced compulsory labelling of genetically modified foods? Research from the UK suggests that many secondary school students do not understand the processes or implications of modern biotechnology. The situation in Australia is unclear. In this study, 1116 15-year-old students from eleven Western Australian schools were surveyed to determine their understanding of, and attitude towards, recent advances in modern biotechnology. The results indicate that approximately one third of students have little or no understanding of biotechnology. Many students over-estimate the use of biotechnology in our society by confusing current uses with possible future applications. The results provide a rationale for the inclusion of biotechnology, a cutting edge science, in the school science curriculum

  1. Understanding Quality Culture

    Science.gov (United States)

    Ehlers, Ulf Daniel

    2009-01-01

    Purpose: The purpose of this paper is to develop a holistic understanding of quality in higher education which reveals the current debates about accreditation or quality process standards as insufficient, and to propose an enhanced model for quality culture in educational organisations. Design/methodology/approach: The conceptual framework is…

  2. Understanding Quality Culture

    Science.gov (United States)

    Ehlers, Ulf Daniel

    2009-01-01

    Purpose: The purpose of this paper is to develop a holistic understanding of quality in higher education which reveals the current debates about accreditation or quality process standards as insufficient, and to propose an enhanced model for quality culture in educational organisations. Design/methodology/approach: The conceptual framework is…

  3. Proficiency: Understanding the Construct.

    Science.gov (United States)

    Lantolf, James P.; Frawley, William

    1988-01-01

    Argues against the current oral proficiency testing approach in favor of an approach in which researchers come to understand what it means for real speakers to interact with each other in the everyday world of human activity. Problematic trends are addressed, and a principled theory of oral proficiency is identified. (DJD)

  4. LISTENING TO UNDERSTAND OR READING TO UNDERSTAND

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    Introduction This article is based on the experience of teaching extensive reading classes for science students in our school. It describes a common model for reading classes. This model shows the disadvantage that readers tend to understand what they read mainly by way of listening to the teacher’s explanation, but not by reading for themselves. It has given rise to the particular problem of whether students need a full explanation before achieving good comprehension. The article suggests that readers have to work themselves to improve their reading ability and skills. Some techniques for teaching a reading class are suggested.

  5. Understanding biplots

    CERN Document Server

    Gower, John C; Le Roux, Niel J

    2010-01-01

    Biplots are a graphical method for simultaneously displaying two kinds of information; typically, the variables and sample units described by a multivariate data matrix or the items labelling the rows and columns of a two-way table. This book aims to popularize what is now seen to be a useful and reliable method for the visualization of multidimensional data associated with, for example, principal component analysis, canonical variate analysis, multidimensional scaling, multiplicative interaction and various types of correspondence analysis. Understanding Biplots: Introduces th

  6. Understanding uncertainty

    CERN Document Server

    Lindley, Dennis V

    2013-01-01

    Praise for the First Edition ""...a reference for everyone who is interested in knowing and handling uncertainty.""-Journal of Applied Statistics The critically acclaimed First Edition of Understanding Uncertainty provided a study of uncertainty addressed to scholars in all fields, showing that uncertainty could be measured by probability, and that probability obeyed three basic rules that enabled uncertainty to be handled sensibly in everyday life. These ideas were extended to embrace the scientific method and to show how decisions, containing an uncertain element, could be rationally made.

  7. Understanding ayurveda.

    Science.gov (United States)

    Gadgil, Vaidya Dilip

    2010-01-01

    Ayurveda needs to achieve its full potential both in India and globally. This requires imparting to its students full appreciation of Ayurveda's power and strength, particularly proper understanding of the advantages of applying it to treat chronic and acute diseases. To this end, we explain the necessity of learning Sanskrit as a medium of study, and the advantages of learning the Texts in the traditional way, rather than relying on translations with all the loss of meaning and precision, which that entails. We emphasize the use of Triskandhakosha as a means to fully understand Ayurveda fundamental concepts and technical terms, so that all their shades of meaning are fully understood, and all their usages given in different places in the texts. Only by such methods can full appreciation of Ayurvedic wisdom be achieved, and the full depth and power of its knowledge be applied. Only then will its true status among systems of medicine come to be appreciated, either in India or more widely in the world as a whole.

  8. Understanding analysis

    CERN Document Server

    Abbott, Stephen

    2015-01-01

    This lively introductory text exposes the student to the rewards of a rigorous study of functions of a real variable. In each chapter, informal discussions of questions that give analysis its inherent fascination are followed by precise, but not overly formal, developments of the techniques needed to make sense of them. By focusing on the unifying themes of approximation and the resolution of paradoxes that arise in the transition from the finite to the infinite, the text turns what could be a daunting cascade of definitions and theorems into a coherent and engaging progression of ideas. Acutely aware of the need for rigor, the student is much better prepared to understand what constitutes a proper mathematical proof and how to write one. Fifteen years of classroom experience with the first edition of Understanding Analysis have solidified and refined the central narrative of the second edition. Roughly 150 new exercises join a selection of the best exercises from the first edition, and three more project-sty...

  9. Understanding Constipation

    Science.gov (United States)

    ... dietary fiber, which helps move bulk through the intestines and promote bowel movements. Some studies have suggested that high- fiber diets result in larger stools, more frequent bowel movements and, therefore, less constipation. } Irritable Bowel Syndrome (IBS). Also known as IBS with constipation or ...

  10. Understanding Logarithms

    Science.gov (United States)

    Wood, Eric

    2005-01-01

    A variety of applications of logarithms are presented along with suggestions about how this topic might be made more interesting and relevant in a secondary classroom. In most cases, the treatment is multi-modal using numerical, graphical and algebraic approaches.

  11. Understanding physics

    CERN Document Server

    Cassidy, David; Rutherford, James

    2002-01-01

    Understanding Physics provides a thorough grounding in contemporary physics while placing physics into its social and historical context Based in large part on the highly respected Project Physics Course developed by two of the authors, it also integrates the results of recent pedagogical research The text thus - teaches about the basic phenomena in the physical world and the concepts developed to explain them - shows that science is a rational human endeavor with a long and continuing tradition, involving many different cultures and people - develops facility in critical thinking, reasoned argumentation, evaluation of evidence, mathematical modeling, and ethical values The treatment emphasizes not only what we know but also how we know it, why we believe it, and what effects that knowledge has - Why do we believe the Earth and planets revolve around the Sun? - Why do we believe that matter is made of atoms? - How do relativity theory and quantum mechanics alter our conception of Nature and in what ways do th...

  12. Exploration of Opinion-aware Approach to Contextual Suggestion

    Science.gov (United States)

    2014-11-01

    currently valid OMB control number. 1. REPORT DATE NOV 2014 2. REPORT TYPE 3. DATES COVERED 00-00-2014 to 00-00-2014 4. TITLE AND SUBTITLE...suggestion are crawled. Approximately 60,442 candidate sug- gestions are crawled for all contexts, resulting in average 1208 candidate suggestions per

  13. Understanding bulimia.

    Science.gov (United States)

    Hay, Phillipa J

    2007-09-01

    Bulimia nervosa (BN) and related eating disorders such as binge eating disorder are common. General practitioners can play a key role in the identification and management of BN and related eating disorders. This article describes the presenting and associated features of BN and overviews evidence based treatment approaches. Key features are recurrent episodes of binge eating, extreme weight control behaviours and over concern about weight and shape issues. By definition people are not underweight. Risk factors include being from a western culture, obesity, exposure to a restrictive dieting environment and low self esteem. People are more likely to present asking for help in weight control or a physical problem secondary to the eating disorder. Evidenced based therapies with good outcomes in current use are cognitive behaviour therapy (in full or guided self help forms), high dose fluoxetine, and interpersonal psychotherapy. It is important to convey optimism about treatment efficacy and outcomes.

  14. Editorial Commentary: Helping Those Who Seek the Company of "Lord Stanley": Hockey Players and Hip Injuries Highlight the Current State and Future Challenges in Understanding, Treating, and Preventing Nonarthritic Hip Disease.

    Science.gov (United States)

    Christoforetti, John

    2016-09-01

    The state of the art in caring for athletic hip injuries requires comprehensive understanding of dynamic sport-specific biomechanical demands, accurate musculoskeletal diagnosis, and a mindset towards matching hip structure with functional demand at all levels of play. The sport of hockey presents a unique opportunity to review these fundamentals of modern management and illuminates the way towards future understanding of the cause of common nonarthritic hip conditions.

  15. Understanding aging.

    Science.gov (United States)

    Strehler, B L

    2000-01-01

    Enormous advances in our understanding of human aging have occurred during the last 50 yr. From the late 19th to the mid-20th centuries only four comprehensive and important sources of information were available: 1. August Weismann's book entitled Essays on Heredity and Kindred Biological Problems (the first of these essays dealt with The Duration of Life; 1). Weissmann states (p. 10) "In the first place in regulating the length of life, the advantage to the species, and not to the individual, is alone of any importance. This must be obvious to any one who has once thoroughly thought out the process of natural selection_". 2. A highly systematized second early source of information on aging was the collection of essays edited by Cowdry and published in 1938. This 900+ page volume contains 34 chapters and was appropriately called Problems of Aging. 3. At about the same time Raymond Pearl published his book on aging (2). Pearl believed that aging was the indirect result of cell specialization and that only the germ line was resistant to aging. Unfortunately Pearl died in the late 1930s and is largely remembered now for having been the founding editor of Quarterly Review of Biology while he was at the Johns Hopkins University, this author's alma mater. 4. Alexis Carrel wrote a monumental scientific and philosophical book, Man, the Unknown (3). Carrel believed that he had demonstrated that vertebrate cells could be kept in culture and live indefinitely, a conclusion challenged by others (more on this later).

  16. Suggestibility and negative priming: two replication studies.

    Science.gov (United States)

    David, Daniel; Brown, Richard J

    2002-07-01

    Research suggests that inhibiting the effect of irrelevant stimuli on subsequent thought and action (cognitive inhibition) may be an important component of suggestibility. Two small correlation studies were conducted to address the relationship between different aspects of suggestibility and individual differences in cognitive inhibition, operationalized as the degree of negative priming generated by to-be-ignored stimuli in a semantic categorization task. The first study found significant positive correlations between negative priming, hypnotic suggestibility, and creative imagination; a significant negative correlation was obtained between negative priming and interrogative suggestibility, demonstrating the discriminant validity of the study results. The second study replicated the correlation between negative priming and hypnotic suggestibility, using a different suggestibility measurement procedure that assessed subjective experience and hypnotic involuntariness as well as objective responses to suggestions. These studies support the notion that the ability to engage in cognitive inhibition may be an important component of hypnotic responsivity and maybe of other forms of suggestibility.

  17. 西北五省(区)城市绿地果树应用现状及发展建议%Current Situation and Development Suggestions for Application of Fruit Trees in Urban Landscape in 5 Provinces in Northwest China

    Institute of Scientific and Technical Information of China (English)

    杜晓丽

    2015-01-01

    分析了果树在西北地区城市绿地中应用种类、配置形式、景观效果,探讨了果树在城市绿地景观中独特作用.%The application species, configuration and landscape effect of fruit trees in northwest China are analyzed and some suggestions for development of fruit trees in urban landscape are put forward.

  18. Understanding Poverty

    Directory of Open Access Journals (Sweden)

    Anne Jerneck

    2015-11-01

    Full Text Available Policies and strategies to fight global environmental degradation, gender inequality, and poverty are often inadequate, ineffective, or insufficient. In response, this article seeks potential synergies and leverage points between three significant interrelated discourses that are often treated separately—development, gender, and environment. Proceeding from a brief history of development thinking and poverty definitions, I describe indicators, strategies, and approaches to poverty reduction and gender equality. Second, I analyze how targeting, mainstreaming, and market-based initiatives all fail both to distinguish empirical from analytical gender and to incorporate environment and gender into development policy and action—despite their key role in meeting the normative goal of poverty reduction. Third, through a political-ecology lens, I suggest an integrated approach to poverty, inequality, and socioenvironmental challenges that arise at the intersections of development, gender, and environment, and for that, I draw examples from research on social and environmental change and action in sub-Saharan Africa.

  19. Understanding PISA

    Directory of Open Access Journals (Sweden)

    Stephen DOWNES

    2005-04-01

    Full Text Available Understanding PISA Stephen DOWNESMoncton, CANADA ABSTRACT The headline was dramatic enough to cause a ripple in the reading public. "Students who use computers a lot at school have worse maths and reading performance," noted the BBC news article, citing a 2004 study by Ludger Woessmann and Thomas Fuchs (Fuchs and Woessman, 2004. It was not long before the blogosphere took notice. Taking the theme and running with it, Alice and Bill ask, "Computers Make School Kids Dumber?" They theorize, "If you track the admitted decline of education, you'll probably notice that it follows along with the increase of technology in the classroom." In a similar vein, James Bartholomew asks, "Do you think that the government will turn down the volume of its boasting about how it has spent billions introducing computers in schools (while keeping down the pay of teachers so much that there are shortages? Do you think it will stop sending governors of state schools glossy pamphlets about insisting that computers are used in their schools as much as possible?" In this study, therefore, PISA looks well beyond educational attainment, and also includes school demographics, such as whether it is a public or private school, has large or small classes, or has access or not to technological resources. Finally, it does measure student information-their family background, access to books and computers and parental support as well. The PISA survey departs from previous surveys in disregarding the stated curricula of the schools being measured. Therefore, the conclusion is not surprising, nor even wrong for him to consider independently of any parental or teacher support, considered without reference to the software running on it, considered without reference to student attitudes and interests, does not positively impact an education. Finally, he focus on missing the reporting of results

  20. "I Didn't Mean to...": Practical Suggestions for Understanding and Teaching Students with Sexualized Behavior

    Science.gov (United States)

    Rappaport, Nancy; Minahan, Jessica

    2013-01-01

    There is no definitive research on how many students display sexualized behavior in schools. Sexually inappropriate behavior includes using sexual language, gestures, or noises, engaging in pretend play that simulates sex, making sexual invitations to others, inappropriately touching another person, or masturbating in the classroom. These…

  1. Understanding Students' Attitudes about Group Work: What Does This Suggest for Instructors of Business?

    Science.gov (United States)

    Marks, Melanie Beth; O'Connor, Abigail H.

    2013-01-01

    A survey was administered to college students to gain insight into their attitudes about classroom group work. Students responded that group work is generally a positive experience; however, they do not necessarily prefer it to individual assignments. Students' responses also indicated concerns about instructors' motivations for using…

  2. Sending Hidden Data via Google Suggest

    CERN Document Server

    Bialczak, Piotr; Szczypiorski, Krzysztof

    2011-01-01

    Google Suggest is a service incorporated within Google Web Search which was created to help user find the right search phrase by proposing the autocompleting popular phrases while typing. The paper presents a new network steganography method called StegSuggest which utilizes suggestions generated by Google Suggest as a hidden data carrier. The detailed description of the method's idea is backed up with the analysis of the network traffic generated by the Google Suggest to prove its feasibility. The traffic analysis was also performed to discover the occurrence of two TCP options: Window Scale and Timestamp which StegSuggest uses to operate. Estimation of method steganographic bandwidth proves that it is possible to insert 100 bits of steganogram into every suggestions list sent by Google Suggest service.

  3. Reinventing suggestion systems for continuous improvement

    NARCIS (Netherlands)

    Schuring, R.W.; Luijten, Harald

    2001-01-01

    This article reports an experiment to increase the effectiveness of a suggestion system by deliberately applying principles of the kaizen and performance management. Design rules for suggestion systems are derived from these theories. The suggestion system that resulted differs from traditional

  4. Reinventing suggestion systems for continuous improvement

    NARCIS (Netherlands)

    Schuring, Roel W.; Luijten, Harald

    2001-01-01

    This article reports an experiment to increase the effectiveness of a suggestion system by deliberately applying principles of the kaizen and performance management. Design rules for suggestion systems are derived from these theories. The suggestion system that resulted differs from traditional sugg

  5. Hepatitis B in Bangladesh: Further Suggestions

    Directory of Open Access Journals (Sweden)

    Mohammad Shafiul Jamal

    2006-06-01

    Full Text Available Iread with great interest Rashid and Rafiq's article published in the spring issue of this journal(1. The authors not only highlighted the shortcomings of the current hepatitis B vaccination strategy in Bangladesh but also prescribed awonderful policy, which is felt to be both costeffective and befitting with the country's existing programme on immunization. To complement thisI would like to add few more points: ||l|| Most neonates mount an immune response, which is believed to be adequate to reduce their risk of perinatal Hepatitis B Virus (HBV acquisition after vaccination(2. Though the pre-term babies (<37 weeks show a slower response than the term (||“||37 weeks babies, immunogenicity, which is inversely proportional to the gestational age, can be improved by increasing the vaccine dosage (2,3. l| Timing first dose of hepatitis B vaccine with BCG probably has a positive interaction: administration of BCG at the time of HBV vaccine priming at birth markedly increases the cytokines as well as ntibody responses to HBV vaccine(4. This astonishing finding might suggest that BCG has a synergistic effect on hepatitis B vaccination. Bangladesh is reported to have a very high (94% coverage of BCG vaccine(5; the uptake of HBV vaccine can be equally improved by timing it with BCG.l| The present infant vaccination policy will leave adolescents unguarded and hence nationwide prevention of the disease will be delayed. A recent survey unveils that available infrastructure in Bangladesh has sufficient spare capacity to sustain storage of an increased quantity of vaccines(5. To make good use of this unused legroom adolescent vaccination should be started along with infant vaccination. Countries such as Spain and Portugal have both neonatal and adolescent vaccination programmes in place, since 1993 and 2000 respectively, and these countries will be able to end the adolescent programme once the first immunised newborn cohort has reached the target age of the

  6. Regulating professional behavior: codes of ethics or law? Suggested criteria.

    Science.gov (United States)

    Libman, Liron A

    2013-09-01

    This paper suggests considering a few parameters when making policy decisions as to the proper "tool" to regulate professional behavior: law or professional ethics. This is done on the background of understanding the place of codes of professional ethics between "pure" ethics and law. Suggested criteria are then illustrated using a few examples. Further discourse may reveal additional factors to support a more rational process of decision-making in this field.

  7. Towards better process understanding

    DEFF Research Database (Denmark)

    Matero, Sanni Elina; van der Berg, Franciscus Winfried J; Poutiainen, Sami

    2013-01-01

    , current best practice to control a typical process is to not allow process-related factors to vary i.e. lock the production parameters. The problem related to the lack of sufficient process understanding is still there: the variation within process and material properties is an intrinsic feature...... and cannot be compensated for with constant process parameters. Instead, a more comprehensive approach based on the use of multivariate tools for investigating processes should be applied. In the pharmaceutical field these methods are referred to as Process Analytical Technology (PAT) tools that aim...... to achieve a thorough understanding and control over the production process. PAT includes the frames for measurement as well as data analyzes and controlling for in-depth understanding, leading to more consistent and safer drug products with less batch rejections. In the optimal situation, by applying...

  8. Understanding Pregnancy and Birth Issues

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues Understanding Pregnancy and Birth Issues Past Issues / Winter 2008 Table ... turn Javascript on. What is a High-Risk Pregnancy? All pregnancies involve a certain degree of risk ...

  9. Hypnotizability, not suggestion, influences false memory development.

    Science.gov (United States)

    Dasse, Michelle N; Elkins, Gary R; Weaver, Charles A

    2015-01-01

    Hypnotizability influences the development of false memories. In Experiment 1, participants heard a positive or negative suggestion regarding hypnosis and then listened to 8 Deese-Roediger-McDermott (DRM) false memory paradigm lists in a hypnotic state. Neither hypnosis nor prehypnotic suggestion affected memory. Highly hypnotizable participants were more accurate in recall and recognition. In Experiment 2, suggestions were delivered in the form of feedback. Participants heard a positive or negative suggestion about their performance prior to either the encoding or retrieval of 8 DRM lists. Neither accurate nor false memories were affected by the suggestion. Highly hypnotizable individuals recognized fewer critical lures if they received a negative suggestion about their performance. These results highlight the unusual role of hypnotizability in the creation of false memories.

  10. Interrogative suggestibility and perceptual motor performance.

    Science.gov (United States)

    Gudjonsson, G H

    1984-04-01

    This study investigates the relationship between interrogative suggestibility, as measured by the Gudjonsson Suggestibility Scale, and Arrow-Dot scores. The tendency of subjects (25 men and 25 women, mean age 30.2 yr.) to alter their answers once interpersonal pressure had been applied correlated significantly with poor Arrow-Dot Ego functioning.

  11. Query term suggestion in academic search

    NARCIS (Netherlands)

    Verberne, S.; Sappelli, M.; Kraaij, W.

    2014-01-01

    In this paper, we evaluate query term suggestion in the context of academic professional search. Our overall goal is to support scientists in their information seeking tasks. We set up an interactive search system in which terms are extracted from clicked documents and suggested to the user before e

  12. Query term suggestion in academic search

    NARCIS (Netherlands)

    Verberne, S.; Sappelli, M.; Kraaij, W.

    2014-01-01

    In this paper, we evaluate query term suggestion in the context of academic professional search. Our overall goal is to support scientists in their information seeking tasks. We set up an interactive search system in which terms are extracted from clicked documents and suggested to the user before

  13. Maltreated Children's Memory: Accuracy, Suggestibility, and Psychopathology

    Science.gov (United States)

    Eisen, Mitchell L.; Goodman, Gail S.; Qin, Jianjian; Davis, Suzanne; Crayton, John

    2007-01-01

    Memory, suggestibility, stress arousal, and trauma-related psychopathology were examined in 328 3- to 16-year-olds involved in forensic investigations of abuse and neglect. Children's memory and suggestibility were assessed for a medical examination and venipuncture. Being older and scoring higher in cognitive functioning were related to fewer…

  14. Spin current

    CERN Document Server

    Valenzuela, Sergio O; Saitoh, Eiji; Kimura, Takashi

    2012-01-01

    In a new branch of physics and technology called spin-electronics or spintronics, the flow of electrical charge (usual current) as well as the flow of electron spin, the so-called 'spin current', are manipulated and controlled together. This book provides an introduction and guide to the new physics and application of spin current.

  15. Registro e tecnovigilância de implantes dentários: panorama atual nos EUA, na União Europeia, no Brasil e sugestões de aprimoramento desses sistemas | Registry and surveillance of dental implants: current panorama in the USA, European Union, Brazil and suggestions for improved systems

    Directory of Open Access Journals (Sweden)

    Diana Ribeiro do Espírito Santo Jacomo

    2016-05-01

    reporting, as well as a long time between problems identification and the action (due to the extension of the administrative process. In the European Union the few identified studies suggested that the regulatory system provides risks to patients related to the lack of transparency among notifying organs and to the difficulty in articulating the post-marketing surveillance among countries. In Brazil, the post-marketing surveillance is centralized, and is still in its infancy, having the “sentinel” hospitals and “Notivisa” as its main initiatives. Population ageing promotes strong demand for patients’ oral rehabilitation, especially the needy included in the “Smiling Brazil” program. The service demand may offer a market expansion opportunity, but it also poses a risk of low-quality products entry. In this context, the improvement of post-market surveillance activities of dental implants becomes a priority.

  16. Suggestions for Preview in Learning English

    Institute of Scientific and Technical Information of China (English)

    Sun Na

    2015-01-01

    Among the factors which affect the efficiency of learning English, preview stands out as an increasingly significant one in English studying.Some constructive suggestions about the preview are given to apply in the preview of English.

  17. FDA Suggests Limits on Lead in Cosmetics

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_162726.html FDA Suggests Limits on Lead in Cosmetics Agency notes ... the authority to enforce such a limit, the FDA recommended in a draft guidance issued Thursday that ...

  18. LSD enhances suggestibility in healthy volunteers.

    Science.gov (United States)

    Carhart-Harris, R L; Kaelen, M; Whalley, M G; Bolstridge, M; Feilding, A; Nutt, D J

    2015-02-01

    Lysergic acid diethylamide (LSD) has a history of use as a psychotherapeutic aid in the treatment of mood disorders and addiction, and it was also explored as an enhancer of mind control. The present study sought to test the effect of LSD on suggestibility in a modern research study. Ten healthy volunteers were administered with intravenous (i.v.) LSD (40-80 μg) in a within-subject placebo-controlled design. Suggestibility and cued mental imagery were assessed using the Creative Imagination Scale (CIS) and a mental imagery test (MIT). CIS and MIT items were split into two versions (A and B), balanced for 'efficacy' (i.e. A ≈ B) and counterbalanced across conditions (i.e. 50 % completed version 'A' under LSD). The MIT and CIS were issued 110 and 140 min, respectively, post-infusion, corresponding with the peak drug effects. Volunteers gave significantly higher ratings for the CIS (p = 0.018), but not the MIT (p = 0.11), after LSD than placebo. The magnitude of suggestibility enhancement under LSD was positively correlated with trait conscientiousness measured at baseline (p = 0.0005). These results imply that the influence of suggestion is enhanced by LSD. Enhanced suggestibility under LSD may have implications for its use as an adjunct to psychotherapy, where suggestibility plays a major role. That cued imagery was unaffected by LSD implies that suggestions must be of a sufficient duration and level of detail to be enhanced by the drug. The results also imply that individuals with high trait conscientiousness are especially sensitive to the suggestibility-enhancing effects of LSD.

  19. Euthanasia and Mental Retardation: Suggesting the Unthinkable.

    Science.gov (United States)

    Hollander, Russell

    1989-01-01

    The article examines current opinions toward euthanasia of persons with mental retardation in light of the history of public and professional attitudes. It also discusses the rejection of euthanasia on moral and religious grounds, and notes the use of lifelong incarceration, based on eugenics principles, to accomplish similar ends. (DB)

  20. Brand Development Suggestions of Chinese Clothing Enterprises

    Institute of Scientific and Technical Information of China (English)

    张霞; 陈素英

    2013-01-01

    According to the analysis of the current situation and problems of Chinese clothing brand, the corresponding measures are raised from three aspects of brand positioning, brand broadcast and brand extension strategy. Some guidance and reference value is provided for the brand building and upgrading of Chinese clothing brand.

  1. Elementary Introduction and Suggestion on Ecotourism

    Institute of Scientific and Technical Information of China (English)

    WangXlaoxlao

    2005-01-01

    The ecotourism is a combination of popularizing ecological, scientific knowledge and increasing the nation's awareness of protection of nature. Therefore, it is a better form for national forest parks and nature reserves to fully publicize the necessity of environmental protection. The combination of ecology with tourism is the current world-developing tendency.

  2. Euthanasia and Mental Retardation: Suggesting the Unthinkable.

    Science.gov (United States)

    Hollander, Russell

    1989-01-01

    The article examines current opinions toward euthanasia of persons with mental retardation in light of the history of public and professional attitudes. It also discusses the rejection of euthanasia on moral and religious grounds, and notes the use of lifelong incarceration, based on eugenics principles, to accomplish similar ends. (DB)

  3. Suggested Interventions for Young Adults' Relationship Issues

    Science.gov (United States)

    Terneus, Sandra K.; Martin, H. Dan

    2005-01-01

    Professionals in the social psychology field concur that teenagers and young adults may not have the appropriate skills and ego strength to affirm healthy relationship decisions. This article reviews current research regarding partner selection from adolescence through early adulthood. It also provides appendices of interventions used in clinical…

  4. Impulsivity, self-control, and hypnotic suggestibility.

    Science.gov (United States)

    Ludwig, V U; Stelzel, C; Krutiak, H; Prunkl, C E; Steimke, R; Paschke, L M; Kathmann, N; Walter, H

    2013-06-01

    Hypnotic responding might be due to attenuated frontal lobe functioning after the hypnotic induction. Little is known about whether personality traits linked with frontal functioning are associated with responsiveness to hypnotic suggestions. We assessed whether hypnotic suggestibility is related to the traits of self-control and impulsivity in 154 participants who completed the Brief Self-Control Scale, the Self-Regulation Scale, the Barratt Impulsiveness Scale (BIS-11), and the Harvard Group Scale of Hypnotic Susceptibility (HGSHS:A). BIS-11 non-planning impulsivity correlated positively with HGSHS:A (Bonferroni-corrected). Furthermore, in the best model emerging from a stepwise multiple regression, both non-planning impulsivity and self-control positively predicted hypnotic suggestibility, and there was an interaction of BIS-11 motor impulsivity with gender. For men only, motor impulsivity tended to predict hypnotic suggestibility. Hypnotic suggestibility is associated with personality traits linked with frontal functioning, and hypnotic responding in men and women might differ. Copyright © 2013 Elsevier Inc. All rights reserved.

  5. Mathematics for understanding disease.

    Science.gov (United States)

    Bies, R R; Gastonguay, M R; Schwartz, S L

    2008-06-01

    The application of mathematical models to reflect the organization and activity of biological systems can be viewed as a continuum of purpose. The far left of the continuum is solely the prediction of biological parameter values, wherein an understanding of the underlying biological processes is irrelevant to the purpose. At the far right of the continuum are mathematical models, the purposes of which are a precise understanding of those biological processes. No models in present use fall at either end of the continuum. Without question, however, the emphasis in regards to purpose has been on prediction, e.g., clinical trial simulation and empirical disease progression modeling. Clearly the model that ultimately incorporates a universal understanding of biological organization will also precisely predict biological events, giving the continuum the logical form of a tautology. Currently that goal lies at an immeasurable distance. Nonetheless, the motive here is to urge movement in the direction of that goal. The distance traveled toward understanding naturally depends upon the nature of the scientific question posed with respect to comprehending and/or predicting a particular disease process. A move toward mathematical models implies a move away from static empirical modeling and toward models that focus on systems biology, wherein modeling entails the systematic study of the complex pattern of organization inherent in biological systems.

  6. Suggestions on Leapfrogging Development in Tibet

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    @@ The realization of leapfrogging socio-economic development in the Tibet Autonomous Region remains a key issue in the current drive to develop Western China. In this connection, the CAS Academic Divisions have sponsored a task force of a dozen CAS members and nearly 30 other experts to conduct comprehensive studies on the subject, and presented a feasibility study report to the central government. Some of their main ideas are as follows:

  7. Suggestions for Structuring a Research Article

    Science.gov (United States)

    Klein, James D.; Reiser, Robert A.

    2014-01-01

    Researchers often experience difficulty as they attempt to prepare journal articles that describe their work. The purpose of this article is to provide researchers in the field of education with a series of suggestions as to how to clearly structure each section of a research manuscript that they intend to submit for publication in a scholarly…

  8. Three Suggestions to Improve Medical English Teaching

    Institute of Scientific and Technical Information of China (English)

    黄佳丽

    2012-01-01

    As a kind of ESP,medical English teaching has an important impact on both English teachers and medical students.A good medical English teaching can help the medical students to improve themselves smoothly and easily in the medical area.In this article,three suggestions were provided for the medical English teachers to improve their English teaching in medical field.

  9. BJUT at TREC 2015 Contextual Suggestion Track

    Science.gov (United States)

    2015-11-20

    of Technology, Beijing 100124, China 2. Beijing Key Laboratory of Trusted Computing, Beijing 100124, China 3. National Engineering Laboratory for...CTISCP, Beijing 100124, China ⇤yangzhen@bjut.edu.cn Abstract In this paper we described our efforts for TREC contextual suggestion task. Our goal of this

  10. Physics Courses--Some Suggested Case Studies

    Science.gov (United States)

    Swetman, T. P.

    1972-01-01

    To communicate the relevance and excitement of science activity to students, the use of more imaginative, and even openly speculative, case studies in physics courses is suggested. Some useful examples are Magnetic Monopoles, Constants, Black Holes, Antimatter, Zero Mass Particles, Tachyons, and the Bootstrap Hypothesis. (DF)

  11. Overview of the SBS 2016 Suggestion Track

    DEFF Research Database (Denmark)

    Koolen, Marijn; Bogers, Toine; Jaap, Kamps

    2016-01-01

    The goal of the SBS 2016 Suggestion Track is to evaluate approaches for supporting users in searching collections of books who express their information needs both in a query and through example books. The track investigates the complex nature of relevance in book search and the role of traditional...

  12. Studies and Suggestions on Prewriting Activities

    Science.gov (United States)

    Zheng, Shigao; Dai, Weiping

    2012-01-01

    This paper studies and suggests the need for writing instruction by which students can experience writing as a creative process in exploring and communicating meaning. The prewriting activities generate ideas which can encourage a free flow of thoughts and help students discover both what they want to say and how to say it on paper. Through the…

  13. Qualitative Research Articles: Guidelines, Suggestions and Needs

    Science.gov (United States)

    Crescentini, Alberto; Mainardi, Giuditta

    2009-01-01

    Purpose: The purpose of this paper is to give ideas and suggestions to avoid some typical problems of qualitative articles. The aim is not to debate quality in qualitative research but to indicate some practical solutions. Design/methodology/approach: The paper discusses the design of qualitative research and the structure of a qualitative article…

  14. Teaching Software Engineering: Problems and Suggestions

    Directory of Open Access Journals (Sweden)

    Osama Shata

    2011-01-01

    Full Text Available Teaching Software Engineering is a challenging task. This paper presents some problems encountered during teaching the course of software engineering to computer science and computer engineering students for few offerings. We present problems encountered and which are related to its title and contents and present suggested solutions.

  15. Strength Testing in the Air Force: Current Processes and Suggestions for Improvements

    Science.gov (United States)

    2014-01-01

    male dogs such as rottweilers or bloodhounds (200–260 lbs) an average NFL linebacker (230–270 lbs) - 47 - To reduce survey burden...rottweilers or bloodhounds (200–260 lbs) an average NFL linebacker (230-270 lbs) - 92 - Participants who completed questions in the Action

  16. Bruxism: overview of current knowledge and suggestions for dental implants planning

    NARCIS (Netherlands)

    Manfredini, D.; Bucci, M.B.; Sabattini, V.B.; Lobbezoo, F.

    2011-01-01

    Bruxism is commonly considered a detrimental motor activity, potentially causing overload of the stomatognathic structures and representing a risk factor for dental implant survival. The available literature does not provide evidence-based guidelines for the management of bruxers undergoing implant-

  17. Techniques of tumour bed boost irradiation in breast conserving therapy: Current evidence and suggested guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Jalali, Rakesh; Singh, Suruchi; Budrukkar, Ashwini [Tata Memorial Hospital, Mumbai (India)

    2007-10-15

    Breast conservation surgery followed by external beam radiotherapy to breast has become the standard of care in management of early carcinoma breast. A boost to the tumour bed after whole breast radiotherapy is employed in view of the pattern of tumour bed recurrences in the index quadrant and was particularly considered in patients with some adverse histopathological characteristics such as positive margins, extensive intraductal carcinoma (EIC), lymphovascular invasion (LVI), etc. There is however, now, a conclusive evidence of improvement in local control rates after a boost radiotherapy dose in patients even without such factors and for all age groups. The maximum absolute reduction of local recurrences by the addition of boost is especially seen in young premenopausal patients. At the same time, the addition of boost is associated with increased risk of worsening of cosmesis and no clear cut survival advantage. Radiological modalities such as fluoroscopy, ultrasound and CT scan have aided in accurate delineation of tumour bed with increasing efficacy. A widespread application of these techniques might ultimately translate into improved local control with minimal cosmetic deficit. The present article discusses the role of radiotherapy boost and the means to delineate and deliver the same, identify the high risk group, optimal technique and the doses and fractionations to be used. It also discusses the extent of adverse cosmetic outcome after boost delivery, means to minimise it and relevance of tumour bed in present day scenario of advanced radiotherapy delivery techniques like (IMRT)

  18. Debating Curricular Strategies for Teaching Statistics and Research Methods: What Does the Current Evidence Suggest?

    Science.gov (United States)

    Barron, Kenneth E.; Apple, Kevin J.

    2014-01-01

    Coursework in statistics and research methods is a core requirement in most undergraduate psychology programs. However, is there an optimal way to structure and sequence methodology courses to facilitate student learning? For example, should statistics be required before research methods, should research methods be required before statistics, or…

  19. The Current Situation in the South China Sea Dispute and Suggested Responses

    Institute of Scientific and Technical Information of China (English)

    Li Jinming

    2012-01-01

    Tensions have been rising over the South China Sea issue in the last year. The return of the U.S. to the Asia-Pacific region has exacerbated the South China Sea dispute. This shift in U.S. strategy has seen concentrations of its land, sea and air forces in the region, in order to strengthen military ties with allies such as Japan, South Korea, Australia and the Philippines, with the clear purpose of containing China.

  20. Suggestions on the Current Electricity Price Level and Policies in China

    Institute of Scientific and Technical Information of China (English)

    Zhang Guohou; Wang Ying

    2009-01-01

    @@ The State Council decided to raise the retail electricity price by 0.25 Yuan/kWh from July,2008.This will,to some extent,relieve the conflicts between power supply and demand,and decrease the economic losses in power industry.Also,the step-by-step strategy on electricity price adopted by the government is favorable to the relief of inflation pressure and the maintenance of national economy's steady development.

  1. Debating Curricular Strategies for Teaching Statistics and Research Methods: What Does the Current Evidence Suggest?

    Science.gov (United States)

    Barron, Kenneth E.; Apple, Kevin J.

    2014-01-01

    Coursework in statistics and research methods is a core requirement in most undergraduate psychology programs. However, is there an optimal way to structure and sequence methodology courses to facilitate student learning? For example, should statistics be required before research methods, should research methods be required before statistics, or…

  2. Suggestions on current national Codex%对当前我国Codex工作的建议

    Institute of Scientific and Technical Information of China (English)

    范志先; 尚梅; 沈翠丽

    2006-01-01

    @@ 国际食品法典委员会(Codex Alimentarius Commission,CAC)是FAO/WHO于1963年建立的政府间协调食品标准计划的国际组织,其宗旨是通过建立国际协调一致的食品标准体系,保护消费者的健康,促进公平的食品贸易.CAC现有包括我国在内的172个成员国和组织,覆盖全球98%的人口,可称为是食品标准的联合国.Codex一般认为是CAC在科学的基础上,依据风险分析原理制定的国际食品标准.截至2005年1月,CAC采用了214项食品标准,52项推荐操作规程,45项导则.

  3. Keloids and Hypertrophic Scars Can Now Be Cured Completely: Recent Progress in Our Understanding of the Pathogenesis of Keloids and Hypertrophic Scars and the Most Promising Current Therapeutic Strategy.

    Science.gov (United States)

    Ogawa, Rei; Akaishi, Satoshi; Kuribayashi, Shigehiko; Miyashita, Tsuguhiro

    2016-01-01

    Keloids and hypertrophic scars are fibroproliferative disorders of the skin that are caused by abnormal healing of injured or irritated skin. It is possible that they are both manifestations of the same fibroproliferative skin disorder and just differ in terms of the intensity and duration of inflammation. These features may in turn be influenced by genetic, systemic, and local risk factors. Genetic factors may include single nucleotide polymorphisms, while systemic factors may include hypertension, pregnancy, hormones, and cytokines. The most important local factor is tension on the scar. Over the past 10 years, our understanding of the pathogenesis of keloids and hypertrophic scars has improved markedly. As a result, these previously intractable scars are now regarded as being treatable. There are many therapeutic options, including surgery, radiation, corticosteroids, 5-fluorouracil, cryotherapy, laser therapy, anti-allergy agents, anti-inflammatory agents, bleaching creams and make-up therapies. However, at present, we believe that the following combination of three therapies most reliably achieves a complete cure: surgery, followed by radiation and the use of steroid tape/plaster.

  4. Extracellular matrix remodeling: the common denominator in connective tissue diseases. Possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure.

    Science.gov (United States)

    Karsdal, Morten A; Nielsen, Mette J; Sand, Jannie M; Henriksen, Kim; Genovese, Federica; Bay-Jensen, Anne-Christine; Smith, Victoria; Adamkewicz, Joanne I; Christiansen, Claus; Leeming, Diana J

    2013-03-01

    Increased attention is paid to the structural components of tissues. These components are mostly collagens and various proteoglycans. Emerging evidence suggests that altered components and noncoded modifications of the matrix may be both initiators and drivers of disease, exemplified by excessive tissue remodeling leading to tissue stiffness, as well as by changes in the signaling potential of both intact matrix and fragments thereof. Although tissue structure until recently was viewed as a simple architecture anchoring cells and proteins, this complex grid may contain essential information enabling the maintenance of the structure and normal functioning of tissue. The aims of this review are to (1) discuss the structural components of the matrix and the relevance of their mutations to the pathology of diseases such as fibrosis and cancer, (2) introduce the possibility that post-translational modifications (PTMs), such as protease cleavage, citrullination, cross-linking, nitrosylation, glycosylation, and isomerization, generated during pathology, may be unique, disease-specific biochemical markers, (3) list and review the range of simple enzyme-linked immunosorbent assays (ELISAs) that have been developed for assessing the extracellular matrix (ECM) and detecting abnormal ECM remodeling, and (4) discuss whether some PTMs are the cause or consequence of disease. New evidence clearly suggests that the ECM at some point in the pathogenesis becomes a driver of disease. These pathological modified ECM proteins may allow insights into complicated pathologies in which the end stage is excessive tissue remodeling, and provide unique and more pathology-specific biochemical markers.

  5. Marine organism concentrations, carbonate chemistry variables, and nutrient concentrations from Atlantis ecosystem model simulation output in the California Current from 2013-01-01 to 2053-12-31 to understand vulnerability of California current food webs and economics to ocean acidification (NCEI Accession 0131198)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This archival package contains the model output of a study to evaluate likely economic and ecological outcomes of ocean acidification in the California Current....

  6. Simple nonlinear models suggest variable star universality

    CERN Document Server

    Lindner, John F; Kia, Behnam; Hippke, Michael; Learned, John G; Ditto, William L

    2015-01-01

    Dramatically improved data from observatories like the CoRoT and Kepler spacecraft have recently facilitated nonlinear time series analysis and phenomenological modeling of variable stars, including the search for strange (aka fractal) or chaotic dynamics. We recently argued [Lindner et al., Phys. Rev. Lett. 114 (2015) 054101] that the Kepler data includes "golden" stars, whose luminosities vary quasiperiodically with two frequencies nearly in the golden ratio, and whose secondary frequencies exhibit power-law scaling with exponent near -1.5, suggesting strange nonchaotic dynamics and singular spectra. Here we use a series of phenomenological models to make plausible the connection between golden stars and fractal spectra. We thereby suggest that at least some features of variable star dynamics reflect universal nonlinear phenomena common to even simple systems.

  7. Cajal's brief experimentation with hypnotic suggestion.

    Science.gov (United States)

    Stefanidou, Maria; Solà, Carme; Kouvelas, Elias; del Cerro, Manuel; Triarhou, Lazaros C

    2007-01-01

    Spanish histologist Santiago Ramón y Cajal, one of the most notable figures in Neuroscience, and winner, along with Camillo Golgi, of the 1906 Nobel Prize in Physiology or Medicine for his discoveries on the structure of the nervous system, did not escape experimenting with some of the psychiatric techniques available at the time, mainly hypnotic suggestion, albeit briefly. While a physician in his thirties, Cajal published a short article under the title, "Pains of labour considerably attenuated by hypnotic suggestion" in Gaceta Médica Catalana. That study may be Cajal's only documented case in the field of experimental psychology. We here provide an English translation of the original Spanish text, placing it historically within Cajal's involvement with some of the key scientific and philosophical issues at the time.

  8. Current trends in minilaparoscopy.

    Science.gov (United States)

    Small Layne, Alyssa; Pinkard, Lauren; Shepherd, Jessica

    2016-08-01

    The purpose of this review is to understand the current use of minilaparoscopy in the field and how minilaparoscopy compares with traditional laparoscopy in terms of operative times, complications, pain, and cosmesis. Although there are few randomized controlled trials comparing minilaparoscopy with traditional laparoscopy in gynecologic procedures, the results suggest that minilaparoscopy can be performed safely with improved cosmetic outcomes and similar complication rates and operating times. Postoperative pain may be decreased with minimizing incisions sizes. Recently, case reports and case series have been published demonstrating the use of minilaparoscopy across many subtypes of gynecologic surgery. Traditional laparoscopic surgery has become common practice in gynecology as it has been found to be a well tolerated procedure with improved outcomes and decreased morbidity when compared with laparotomy. Although minilaparoscopy has been used for over 2 decades, its role in gynecology is continuing to evolve. Minilaparoscopy is a growing surgical option in gynecology as we try to minimize the impact of surgery. Results of minilaparoscopy in gynecology mirror those found in urology and general surgery. Although research is limited, minilaparoscopy has proven to be a well tolerated alternative for gynecology.

  9. [Suggestions to improve dentist-endodontist collaboration].

    Science.gov (United States)

    Zabalegui, B; Zabalegui, I; Flores, L

    1989-01-01

    Referrals from the general dentist to the endodontist are in some occasions complicated with lack of proper communication among dentist-patient-specialist, resulting in the loss of confidence or even the patient. Suggestions to improve this communication are discussed, which will provide the patient a higher confidence in the indicated endodontic treatment and a better dental service. It will also enhance the prestige of the general dentists' and specialists' practice.

  10. Pyridoxine dependent epilepsy: a suggestive electroclinical pattern

    OpenAIRE

    1999-01-01

    AIMS—To determine if there is an electroencephalographic pattern suggestive of pyridoxine dependent epilepsy that could be used to improve the chances of early diagnosis.
METHODS—A retrospective study was made of all the clinical records and electroencephalograms of neonates identified with pyridoxine dependent seizures between 1983 and 1994, at this hospital. Neonates whose seizures began after more than 28 days of life were excluded; in all, five patients from four fami...

  11. Suggestions for Improving Translation Teaching Methods

    Institute of Scientific and Technical Information of China (English)

    宋蕾

    2016-01-01

    In the traditional translation teaching mode, the teacher is the main body of classroom, the teachers often explain too much and give few opportunities to students to practice. Even in terms of observation and evaluation of translation, it is also basically teacher-centered, so there is rare opportunity and time for students to debate and to express their own views. So the author gives some suggestions on solving this problem.

  12. Intimate Partner Violence Risk Assessment and Management:Understanding the Current Practice in Hong Kong%香港亲密伴侣暴力危机评估与控制的实践经验和启示

    Institute of Scientific and Technical Information of China (English)

    王玲; 吴清禄; 蔡兆欣

    2016-01-01

    Through the introduction of the theory and practice of risk assessment and controlof intimate part-ner violence in HKSAR,experience will be offered to the prevention of domestic violence in Mainland China and assist the frontline staff in dealing with cases of intimate partner violence.The main content covers intro-duction of risk assessment definition,categorization and current risk assessment practice in Hong Kong;dis-cuss risk management and mode of cross-professional cooperation and propose advice for optimizing the pro-cedures of handling intimate partner violence cases:first,clarify the disposal and intervention process of government departments regarding cases of intimate partner violence;second,building the information net-work for domestic violence;third,strengthening the risk appraisal and control abilities of frontline workers;fourth,multi-department cooperation to promote support and referral service to violence victims and their children;fifth,offering counseling to abusers to help them stop violence;sixth,police should make out standard procedures for the handling of intimate partner violence;seventh,evaluation of current procedures for domestic violence prevention and treatment and its service quality by the social work academics and pro-posing measures for improvement.%通过介绍中国香港特区危机评估的概念、分类和实务,探讨了危机控制、专业跨界别合作模式等方面的内容,提出完善内地亲密伴侣暴力个案防治工作的建议。一是明确政府职能部门对亲密伴侣暴力事件的处置及介入程序;二是建立家庭暴力信息系统;三是加强一线工作人员危机评估和控制的专业能力;四是多部门协作推进对受暴者及其子女的支援和转介服务;五是对施暴者提供辅导服务,助其停止暴力行为;六是警务人员应制定出处理亲密伴侣暴力的标准程序;七是社会工作学术界对现行的防治家庭暴力程序及服务

  13. Current limiters

    Energy Technology Data Exchange (ETDEWEB)

    Loescher, D.H. [Sandia National Labs., Albuquerque, NM (United States). Systems Surety Assessment Dept.; Noren, K. [Univ. of Idaho, Moscow, ID (United States). Dept. of Electrical Engineering

    1996-09-01

    The current that flows between the electrical test equipment and the nuclear explosive must be limited to safe levels during electrical tests conducted on nuclear explosives at the DOE Pantex facility. The safest way to limit the current is to use batteries that can provide only acceptably low current into a short circuit; unfortunately this is not always possible. When it is not possible, current limiters, along with other design features, are used to limit the current. Three types of current limiters, the fuse blower, the resistor limiter, and the MOSFET-pass-transistor limiters, are used extensively in Pantex test equipment. Detailed failure mode and effects analyses were conducted on these limiters. Two other types of limiters were also analyzed. It was found that there is no best type of limiter that should be used in all applications. The fuse blower has advantages when many circuits must be monitored, a low insertion voltage drop is important, and size and weight must be kept low. However, this limiter has many failure modes that can lead to the loss of over current protection. The resistor limiter is simple and inexpensive, but is normally usable only on circuits for which the nominal current is less than a few tens of milliamperes. The MOSFET limiter can be used on high current circuits, but it has a number of single point failure modes that can lead to a loss of protective action. Because bad component placement or poor wire routing can defeat any limiter, placement and routing must be designed carefully and documented thoroughly.

  14. Understanding the Electron

    CERN Document Server

    Knuth, Kevin H

    2015-01-01

    Well over a century after the discovery of the electron, we are still faced with serious conceptual issues regarding precisely what an electron is. Since the development of particle physics and the Standard Model, we have accumulated a great deal of knowledge about the relationships among various subatomic particles. However, this knowledge has not significantly aided in our understanding of the fundamental nature of any particular elementary subatomic particle. The fact that many particle properties, such as position, time, speed, energy, momentum, and component of spin, are observer-dependent suggests that these relevant variables do not represent properties per se, but rather the relationship between the observer and the observed. That is, they reflect details about how the electron influences the observer, and vice versa. Here we attempt to understand this by considering a simple model where particles influence one another in a discrete and direct fashion. The resulting framework, referred to as Influence...

  15. Understanding Games as Played

    DEFF Research Database (Denmark)

    Leino, Olli Tapio

    2009-01-01

    Researchers interested in player’s experience would assumedly, across disciplines, agree that the goal behind enquiries into player’s experience is to understand the how games’ features end up affecting the player’s experience. Much of the contemporary interdisciplinary research into player......’s experience leans toward the empirical-scientific, in the forms (neuro)psychology, sociology and cognitive science, to name a few. In such approaches, for example demonstrating correlation between physiological symptoms and an in-game event may amount to ‘understanding’. However, the experience of computer...... game play is a viable topic also for computer game studies within the general tradition of humanities. In such context, the idea of ‘understanding an experience’ invites an approach focusing on the experienced significance of events and objects within computer game play. This focus, in turn, suggests...

  16. Factor structure of suggestibility revisited: new evidence for direct and indirect suggestibility

    Directory of Open Access Journals (Sweden)

    Romuald Polczyk

    2016-05-01

    Full Text Available Background Yielding to suggestions can be viewed as a relatively stable individual trait, called suggestibility. It has been long proposed that there are two kinds of suggestible influence, and two kinds of suggestibility corresponding to them: direct and indirect. Direct suggestion involves overt unhidden influence, while indirect suggestion concerns influence that is hidden, and the participant does not know that the suggestibility is being measured. So far however, empirical evidence for the existence of the two factors has been scarce. In the present study, more sophisticated and reliable tools for measuring suggestibility were applied than in the previous research, in the hope that better measurement would reveal the factor structure of suggestibility. Two tests of direct suggestibility were used: the Harvard Group Scale of Hypnotic Susceptibility, Form A, measuring hypnotic susceptibility, and the Barber Suggestibility Scale, measuring non-hypnotic direct imaginative suggestibility. Three tests served to measure indirect suggestibility: the Sensory Suggestibility Scale, measuring indirect suggestibility relating to perception; the Gudjonsson Suggestibility Scale, measuring the tendency to yield to suggestive questions and changing answers after negative feedback; and the Emotional Dialogs Tests, measuring the tendency to perceive nonexistent aggression. Participants and procedure In sum, 115 participants were tested, 69 women, 49 men, mean age 22.20 years, SD = 2.20. Participants were tested in two sessions, lasting for a total of four hours. Results Confirmatory factor analyses confirmed the existence of two uncorrelated factors of suggestibility: direct and indirect. Conclusions Suggestibility may indeed involve two factors, direct and indirect, and failure to discover them in previous research may be due to methodological problems.

  17. Suggestions of keeping L2 motivation

    Institute of Scientific and Technical Information of China (English)

    徐斌

    2014-01-01

    How will we keep the motivation during the second language as long as we can, which confuses us, though what the L2 motivation is and how it is developed have been discussed by the psychologists, educators, etc. The aim of this passage is to clarify the basic content of motivation, including the definition, classification, importance, etc. how the current situation is in se-nior high students’English learning motivation, what should be done to keep such motivation. In the following part, it will be read that the introduction, the chapter stating the content and classification of (L 2) motivation, the chapter analyzing the necessity and state of L2 motivation at senor high, the chapter offering approach to keep that motivation, and the conclusion. All of them use the comparison, explanation and cites.

  18. Biomarkers of teratogenesis: suggestions from animal studies.

    Science.gov (United States)

    Giavini, Erminio; Menegola, Elena

    2012-09-01

    Biomarkers of effect are measurable biochemical, physiological or other alterations within an organism that can be recognized as causing an established or potential impairment of embryo-fetal development. They may be identified studying the mechanisms of action of teratogens. Hyperacetylation of histones, oxidative stress, cholesterol and retinoic acid unbalance are some of the identified mechanisms of action of some known teratogens. Nevertheless, their use is not currently applicable in human pregnancy because of the difficulty of the choice of biological material, the time when the material must be obtained, and the invasivity of methods. Furthermore, before using them in human pregnancy studies, biomarkers should be validated in experimental animals and in epidemiologic studies. On the contrary, some biomarkers could be useful in the screening of developmental toxicity of chemicals and drugs, comparing molecules of the same chemical class or with the similar pharmacologic activity, and using adequate in vitro tests, in order to reduce the use of experimental animals.

  19. Didactic Experiments Suggest Enhanced Learning Outcomes

    DEFF Research Database (Denmark)

    Pals Svendsen, Lisbet

    2011-01-01

    The article discusses a didactic experiment carried out at an MA programme at The Copenhagen Business School. The experiment aimed at encouraging students to take charge of their learning processes via a course programme design that would motivate students to take an active part in choosing...... and presenting material in the language studied, just as they were encouraged to systematically use evaluation processes to enhance learning outcomes. Eventually, increased grade point averages suggested that the experiment was successful. The article also mentions subsequent revisions to the original format...

  20. Suggestions about Taxi Service in Beijing

    Institute of Scientific and Technical Information of China (English)

    李颖

    2006-01-01

    @@ No matter what kinds1 of work we are engaged in, we usually play the role of the customers2 in life. Maybe we offer service to our clients, but at the same time, we get service from other people. So, to the society3, it is very important of the level of the service occupations4. In this essay, I want to talk about the service of the taxi in Beijing5. Because there are some problems in this service occupation, I will give three suggestions to these problems6.

  1. Suggestions for Implementing Flipped Classroom in China

    Institute of Scientific and Technical Information of China (English)

    周婷

    2016-01-01

    Educators in the twenty-first century are constantly adopting new technologies and pedagogies. Flipped Classroom Model is one of the most promising approaches to transforming learning experiences, which has been applied to both K-12 edu-cation and higher education at home and abroad. Influenced by culture and learning styles, the effectiveness and concrete imple-mentation strategies of this teaching model is different in different countries. How to localize the model in China is an important question for educators to think about. The paper makes suggestions for implementing Flipped Classroom in China, aiming at helping teachers to flip their classrooms successfully.

  2. Responding to hypnotic and nonhypnotic suggestions: performance standards, imaginative suggestibility, and response expectancies.

    Science.gov (United States)

    Meyer, Eric C; Lynn, Steven Jay

    2011-07-01

    This study examined the relative impact of hypnotic inductions and several other variables on hypnotic and nonhypnotic responsiveness to imaginative suggestions. The authors examined how imaginative suggestibility, response expectancies, motivation to respond to suggestions, and hypnotist-induced performance standards affected participants' responses to both hypnotic and nonhypnotic suggestions and their suggestion-related experiences. Suggestions were administered to 5 groups of participants using a test-retest design: (a) stringent performance standards; (b) lenient performance standards; (c) hypnosis test-retest; (d) no-hypnosis test-retest; and (e) no-hypnosis/hypnosis control. The authors found no support for the influence of a hypnotic induction or performance standards on responding to suggestions but found considerable support for the role of imaginative suggestibility and response expectancies in predicting responses to both hypnotic and nonhypnotic suggestions.

  3. Children's suggestibility research: Things to know before interviewing a child

    Directory of Open Access Journals (Sweden)

    Amelia Courtney Hritz

    2015-01-01

    Full Text Available Children's testimony is often the only evidence of alleged abuse. Thus, the importance of conducting forensic interviews that are free from bias and misleading information is immense, as these could lead to false reports. In the current paper, we review unexpected findings in children's suggestibility that illustrate the difficulty in distinguishing between false and accurate reports. We explore situations in which a younger person's memory account may be more accurate than that of an adult, when a single suggestive interview may be as detrimental as multiple interviews, and when children can make inaccurate reports spontaneously. We conclude with recommendations for interviewers to decrease false reporting by both children and adults.

  4. Chest magnetic resonance imaging: a protocol suggestion

    Directory of Open Access Journals (Sweden)

    Bruno Hochhegger

    2015-12-01

    Full Text Available Abstract In the recent years, with the development of ultrafast sequences, magnetic resonance imaging (MRI has been established as a valuable diagnostic modality in body imaging. Because of improvements in speed and image quality, MRI is now ready for routine clinical use also in the study of pulmonary diseases. The main advantage of MRI of the lungs is its unique combination of morphological and functional assessment in a single imaging session. In this article, the authors review most technical aspects and suggest a protocol for performing chest MRI. The authors also describe the three major clinical indications for MRI of the lungs: staging of lung tumors; evaluation of pulmonary vascular diseases; and investigation of pulmonary abnormalities in patients who should not be exposed to radiation.

  5. Chest magnetic resonance imaging: a protocol suggestion*

    Science.gov (United States)

    Hochhegger, Bruno; de Souza, Vinícius Valério Silveira; Marchiori, Edson; Irion, Klaus Loureiro; Souza Jr., Arthur Soares; Elias Junior, Jorge; Rodrigues, Rosana Souza; Barreto, Miriam Menna; Escuissato, Dante Luiz; Mançano, Alexandre Dias; Araujo Neto, César Augusto; Guimarães, Marcos Duarte; Nin, Carlos Schuler; Santos, Marcel Koenigkam; Silva, Jorge Luiz Pereira e

    2015-01-01

    In the recent years, with the development of ultrafast sequences, magnetic resonance imaging (MRI) has been established as a valuable diagnostic modality in body imaging. Because of improvements in speed and image quality, MRI is now ready for routine clinical use also in the study of pulmonary diseases. The main advantage of MRI of the lungs is its unique combination of morphological and functional assessment in a single imaging session. In this article, the authors review most technical aspects and suggest a protocol for performing chest MRI. The authors also describe the three major clinical indications for MRI of the lungs: staging of lung tumors; evaluation of pulmonary vascular diseases; and investigation of pulmonary abnormalities in patients who should not be exposed to radiation. PMID:26811555

  6. Extant mammal body masses suggest punctuated equilibrium

    Science.gov (United States)

    Mattila, Tiina M; Bokma, Folmer

    2008-01-01

    Is gradual microevolutionary change within species simultaneously the source of macroevolutionary differentiation between species? Since its first publication, Darwin's original idea that phenotypic differences between species develop gradually over time, as the accumulation of small selection-induced changes in successive generations has been challenged by palaeontologists claiming that, instead, new species quickly acquire their phenotypes to remain virtually unchanged until going extinct again. This controversy, widely known as the ‘punctuated equilibrium’ debate, remained unresolved, largely owing to the difficulty of distinguishing biological species from fossil remains. We analysed body masses of 2143 existing mammal species on a phylogeny comprising 4510 (i.e. nearly all) extant species to estimate rates of gradual (anagenetic) and speciational (cladogenetic) evolution. Our Bayesian estimates from mammals as well as separate sub-clades such as primates and carnivores suggest that gradual evolution is responsible for only a small part of body size variation between mammal species. PMID:18595835

  7. Webis at TREC 2014: Web, Session, and Contextual Suggestion Tracks

    Science.gov (United States)

    2014-11-01

    collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE NOV 2014 2. REPORT TYPE 3. DATES COVERED 00...much to improve the result ranking. 4. CONTEXTUAL SUGGESTION TRACK The research question we examine in the Contextual Sug- gestion track is whether a... gestions we build upon state-of-the-art tools. Our first run uses descriptions without explanations while an explanation is added in the second run

  8. Radiographic adenoid evaluation - suggestion of referral parameters

    Directory of Open Access Journals (Sweden)

    Murilo F.N. Feres

    2014-06-01

    Full Text Available OBJECTIVE: this study aimed to evaluate the usefulness of current radiographic measurements, which were originally conceived to evaluate adenoid hypertrophy, as potential referral parameters. METHODS: children aged from 4 to 14 years, of both genders, who presented nasal obstruction complaints, were subjected to cavum radiography. Radiographic examinations (n = 120 were evaluated according to categorical and quantitative parameters, and data were compared to gold-standard videonasopharyngoscopic examination, regarding accuracy (sensitivity, negative predictive value, specificity, and positive predictive value. RESULTS: radiographic grading systems presented low sensitivity for the identification of patients with two-thirds choanal space obstruction. However, some of these parameters presented relatively high specificity rates when three-quarters adenoid obstruction was the threshold of interest. Amongst the quantitative variables, a mathematical model was found to be more suitable for identifying patients with more than two-thirds obstruction. CONCLUSION: this model was shown to be potentially useful as a screening tool to include patients with, at least, two-thirds adenoid obstruction. Moreover, one of the categorical parameters was demonstrated to be relatively more useful, as well as a potentially safer assessment tool to exclude patients with less than three-quarters obstruction, to be indicated for adenoidectomy.

  9. Leishmania major: Parasite Interactions Suggesting Sexuality

    Directory of Open Access Journals (Sweden)

    Sousa Maria Auxiliadora de

    1997-01-01

    Full Text Available In five experiments, Leishmania (Leishmania major (MRHO/SU/59/P-strain grew poorly when seeded in FYTS medium supplemented with 15% fetal calf serum, but presented several peculiar pairs of promastigotes diametrically opposed and attached at their posterior ends (5.8-13.5%. As seen in Giemsa-stained smears, a ring-like line and/or an enlargement, generally occurred at the parasite junction. A close proximity of nuclei, which sometimes were difficult to distinguish from each other, was also observed at this junction. Several of these pairs appeared to be composed of fused cells in which the nuclei could be apparently fused, as shown by fluorescence microscopy to detect ß-tubulin and DNA, and by scanning electron microscopy. Under other culture conditions these pairs were absent or occurred at very low rates (0.2-2.2%. Such pairs differ markedly from longitudinally dividing cells and resemble those described in two other Leishmania species, as well as in Herpetomonas megaseliae and Phytomonas davidi, suggesting steps of a putative sexual process

  10. PROBLEMS AND SUGGESTIONS FOR OFFICE FURNITURE MANUFACTURE

    Directory of Open Access Journals (Sweden)

    Cevdet Söğütlü

    2016-12-01

    Full Text Available This study aims to identify the problems encountered in production lines for office furniture manufacturers and gives suggestions to the problems. For this response, a questionnaire was designed and conducted with directors or owners of 50 office furniture manufacturers of small, medium and large scale size enterprises which were randomly selected from different cities. The questionnaire aims to focus on identifying the fundamental obstacles for production, marketing, sales and law. The data from questionnaire was calculated with frequency numbers and percentages for statistical values. In respect to the scope of dependent variables for the study, relationships between the independent variables such as the size of the company scale and Chi Square Single Analysis of Variance (ANOVA were determined. According to the results, 52% of customers constitute owners. The biggest obstacle is the lack of qualified personnel in office furniture production while 46% of customers complain about pour designs. As a result, the study concludes with specific obstacles for logistics (30%, distributions (18%, unpaid bills after delivery (28%, and unconscious of the consumer (24% in the office furniture sector.

  11. [Evidence that suggest the reality of reincarnation].

    Science.gov (United States)

    Bonilla, Ernesto

    2015-06-01

    Worldwide, children can be found who reported that they have memories of a previous life. More than 2,500 cases have been studied and their specifications have been published and preserved in the archives of the Division of Perceptual Studies at the University of Virginia (United States). Many of those children come from countries where the majority of the inhabitants believe in reincarnation, but others come from countries with different cultures and religions that reject it. In many cases, the revelations of the children have been verified and have corresponded to a particular individual, already dead. A good number of these children have marks and birth defects corresponding to wounds on the body of his previous personality. Many have behaviors related to their claims to their former life: phobias, philias, and attachments. Others seem to recognize people and places of his supposed previous life, and some of their assertions have been made under controlled conditions. The hypothesis of reincarnation is controversial. We can never say that it does not occur, or will obtain conclusive evidence that it happens. The cases that have been described so far, isolated or combined, do not provide irrefutable proof of reincarnation, but they supply evidence that suggest its reality.

  12. Suggested use of vaccines in diabetes

    Directory of Open Access Journals (Sweden)

    Jothydev Kesavadev

    2012-01-01

    Full Text Available Diabetes has emerged as a disease of major public health importance in India affecting the rich and the poor alike. Conventionally, comprehensive diabetes management is aimed at preventing micro and macro vascular complications. However, morbidity and mortality due to infections are also significant. In developing countries like India, the concept of adult immunization is far from reality. Recently the H1N1 pandemic has triggered the necessity for considering immunization in all age groups for the prevention of vaccine-preventable fatal infectious diseases. Considering the economics of immunization in a developing country, providing free vaccines to all adults may not be a practical solution, although the free universal immunization program for children is in existence for several decades. There is no consensus on the use of vaccines in diabetes subjects in India. However, there are some clinics offering routine pneumococcal, influenza and other vaccinations. Patients with diabetes have a deranged immune system making them more prone for infections. Hospitalization and death due to pneumococcal disease and influenza are higher in diabetes patients. They, like other healthy individuals, have a normal humoral response to vaccination with clinically significant benefits. The American Diabetes Association, Advisory Committee on Immunization Practices, Centers for Disease Control and Prevention, World Health Organization, United Kingdom Guidelines and a number of other scientific organizations have well defined guidelines for vaccination in diabetes. In this article we make some suggestions for clinicians in India, regarding use of vaccines in subjects with diabetes.

  13. The Out-of-India hypothesis: What do molecules suggest?

    Indian Academy of Sciences (India)

    Aniruddha Datta-Roy; K Praveen Karanth

    2009-11-01

    The remarkable geological and evolutionary history of peninsular India has generated much interest in the patterns and processes that might have shaped the current distributions of its endemic biota. In this regard the ``Out-of-India” hypothesis, which proposes that rafting peninsular India carried Gondwanan forms to Asia after the break-up of Gondwana super continent, has gained prominence. Here we have reviewed molecular studies undertaken on a range of taxa of supposedly Gondwanan origin to better understand the Out-of-India scenario. This re-evaluation of published molecular studies indicates that there is mounting evidence supporting Out-of-India scenario for various Asian taxa. Nevertheless, in many studies the evidence is inconclusive due to lack of information on the age of relevant nodes. Studies also indicate that not all Gondwanan forms of peninsular India dispersed out of India. Many of these ancient lineages are confined to peninsular India and therefore are relict Gondwanan lineages. Additionally, for some taxa an ``Into India” rather than ``Out-of-India” scenario better explains their current distribution. To identify the ``Out-of-India” component of Asian biota it is imperative that we understand the complex biogeographical history of India. To this end, we propose three oversimplified yet explicit phylogenetic predictions. These predictions can be tested through the use of molecular phylogenetic tools in conjunction with palaeontological and geological data.

  14. Employee suggestion programs: the rewards of involvement.

    Science.gov (United States)

    Mishra, J M; McKendall, M

    1993-09-01

    Successful ESPs are the products of a great deal of effort by managers, administrators, teams, individuals, and reviewers, who are all striving to achieve the goals of increased profitability and enhanced employee involvement. A review of the literature indicates that there are several prescriptions that will increase the likelihood of a successful ESP (see the box). Today's American business prophets sound ceaseless calls to arms in the name of "world class performance," "global competitiveness," "total quality management," and a variety of other buzz terms. A burgeoning industry has evolved that promises, through speeches, teleconferences, seminars, and consulting contracts, to teach American organizations how to achieve excellence. In the face of a sputtering economy and unrelenting competitive pressure, today's managers must translate these laudatory ideals into hands-on reality without sacrificing the firm's profit margin to experimentation. If any idea can help an organization achieve improvement through a workable program, then that idea and that program deserve real consideration. An ESP represents an opportunity to tap the intelligence and resourcefulness of an organization's employees, and by doing so, reap significant cost savings. Those companies and managers that have an ESP program uniformly list economic advantages first when describing the benefits of their employee suggestion programs. But there is another deeper and longer term benefit inherent in an ESP. These programs allow employees to become involved in their organization; they drive deaccession to lower levels, they give employees more responsibility, they foster creative approaches to work, and they encourage creativity in pursuit of company goals.(ABSTRACT TRUNCATED AT 250 WORDS)

  15. Understanding Progress: A Heterodox Approach

    Directory of Open Access Journals (Sweden)

    Blanca Lemus

    2013-01-01

    Full Text Available This paper examines the possibility of understanding and measuring well-being as a result of “progress” on the basis of today’s dominant epistemological framework. Market criteria distort social values by allowing purchasing power to define priorities, likening luxury goods to basic needs; in the process they reinforce patterns of discrimination against disadvantaged social groups and women, introducing fatal distortions into the analysis. Similarly, because there are no appropriate mechanisms to price natural resources adequately, the market overlooks the consequences of the abuse of natural resources, degrading the quality of life, individually and collectively, or—in the framework of Latin American indigenous groups—foreclosing the possibility of “living well”. We critique the common vision of the official development discourse that places its faith on technological innovations to resolve these problems. The analysis points to the need for new models of social and environmental governance to promote progress, approaches like those suggested in the paper that are inconsistent with public policies currently in place. At present, the social groups forging institutions to assure their own well-being and ecological balance are involved in local processes, often in opposition to the proposals of the political leaders in their countries.

  16. Understanding medical practice team roles.

    Science.gov (United States)

    Hills, Laura

    2015-01-01

    Do you believe that the roles your employees play on your medical practice team are identical to their job titles or job descriptions? Do you believe that team roles are determined by personality type? This article suggests that a more effective way to build and manage your medical practice team is to define team roles through employee behaviors. It provides 10 rules of behavioral team roles that can help practice managers to select and build high-performing teams, build more productive team relationships, improve the employee recruitment process, build greater team trust and understanding; and increase their own effectiveness. This article describes in detail Belbin's highly regarded and widely used team role theory and summarizes four additional behavioral team role theories and systems. It offers lessons learned when applying team role theory to practice. Finally, this article offers an easy-to-implement method for assessing current team roles. It provides a simple four-question checklist that will help practice managers balance an imbalanced medical practice team.

  17. Current Titles

    Energy Technology Data Exchange (ETDEWEB)

    Various

    2006-06-01

    This booklet is published for those interested in current research being conducted at the National Center for Electron Microscopy. The NCEM is a DOE-designated national user facility and is available at no charge to qualified researchers. Access is controlled by an external steering committee. Interested researchers may contact Jane Cavlina, Administrator, at 510/486-6036.

  18. Affordances of Augmented Reality in Science Learning: Suggestions for Future Research

    Science.gov (United States)

    Cheng, Kun-Hung; Tsai, Chin-Chung

    2013-08-01

    Augmented reality (AR) is currently considered as having potential for pedagogical applications. However, in science education, research regarding AR-aided learning is in its infancy. To understand how AR could help science learning, this review paper firstly has identified two major approaches of utilizing AR technology in science education, which are named as image- based AR and location- based AR. These approaches may result in different affordances for science learning. It is then found that students' spatial ability, practical skills, and conceptual understanding are often afforded by image-based AR and location-based AR usually supports inquiry-based scientific activities. After examining what has been done in science learning with AR supports, several suggestions for future research are proposed. For example, more research is required to explore learning experience (e.g., motivation or cognitive load) and learner characteristics (e.g., spatial ability or perceived presence) involved in AR. Mixed methods of investigating learning process (e.g., a content analysis and a sequential analysis) and in-depth examination of user experience beyond usability (e.g., affective variables of esthetic pleasure or emotional fulfillment) should be considered. Combining image-based and location-based AR technology may bring new possibility for supporting science learning. Theories including mental models, spatial cognition, situated cognition, and social constructivist learning are suggested for the profitable uses of future AR research in science education.

  19. Intention understanding in autism.

    Directory of Open Access Journals (Sweden)

    Sonia Boria

    Full Text Available When we observe a motor act (e.g. grasping a cup done by another individual, we extract, according to how the motor act is performed and its context, two types of information: the goal (grasping and the intention underlying it (e.g. grasping for drinking. Here we examined whether children with autistic spectrum disorder (ASD are able to understand these two aspects of motor acts. Two experiments were carried out. In the first, one group of high-functioning children with ASD and one of typically developing (TD children were presented with pictures showing hand-object interactions and asked what the individual was doing and why. In half of the "why" trials the observed grip was congruent with the function of the object ("why-use" trials, in the other half it corresponded to the grip typically used to move that object ("why-place" trials. The results showed that children with ASD have no difficulties in reporting the goals of individual motor acts. In contrast they made several errors in the why task with all errors occurring in the "why-place" trials. In the second experiment the same two groups of children saw pictures showing a hand-grip congruent with the object use, but within a context suggesting either the use of the object or its placement into a container. Here children with ASD performed as TD children, correctly indicating the agent's intention. In conclusion, our data show that understanding others' intentions can occur in two ways: by relying on motor information derived from the hand-object interaction, and by using functional information derived from the object's standard use. Children with ASD have no deficit in the second type of understanding, while they have difficulties in understanding others' intentions when they have to rely exclusively on motor cues.

  20. CCSS-ELA Suggestions and Cautions for Addressing Text Complexity

    Science.gov (United States)

    Wixson, Karen K.; Valencia, Sheila W.

    2014-01-01

    The purpose of this article is to provide guidance on the implementation of the Common Core State Standards for English language arts (CCSS-ELA). Toward this end, suggestions and cautions are provided that focus on understanding the vision, understanding the anchor and grade-level standards, and understanding the implications for instruction. In…

  1. CCSS-ELA: Suggestions and Cautions for Implementing the Reading Standards

    Science.gov (United States)

    Valencia, Sheila W.; Wixson, Karen K.

    2013-01-01

    The purpose of this article is to provide guidance on the implementation of the Common Core State Standards for English language arts (CCSS-ELA). Toward this end, suggestions and cautions are provided that focus on understanding the vision, understanding the anchor and grade-level standards, and understanding the implications for instruction. In…

  2. User Suggestions Extraction from customer Reviews A Sentiment Analysis approach

    Directory of Open Access Journals (Sweden)

    Vishwanath.J,

    2011-03-01

    Full Text Available Customer review is a major criterion for the improvement of the quality of services rendered and enhancement of the deliverables. Blogs, articles and discussion forums, provide manufacturers or sellers with a good understanding of the reception level of their products in the competitive market. An interesting area from the business analysis perspective, this paper discusses an opinion based mining technique for the extraction of the relevant data using Natural Language Processing and text analysis, and comprehends suggestions from an actionable feedback.

  3. Six Suggestions for Research on Games in Cognitive Science.

    Science.gov (United States)

    Chabris, Christopher F

    2017-04-01

    Games are more varied and occupy more of daily life than ever before. At the same time, the tools available to study game play and players are more powerful than ever, especially massive data sets from online platforms and computational engines that can accurately evaluate human decisions. This essay offers six suggestions for future cognitive science research on games: (1) Don't forget about chess, (2) Look beyond action games and chess, (3) Use (near)-optimal play to understand human play and players, (4) Investigate social phenomena, (5) Raise the standards for studies of games as treatments, (6) Talk to real experts. Copyright © 2017 Cognitive Science Society, Inc.

  4. Suggestibility under Pressure: Theory of Mind, Executive Function, and Suggestibility in Preschoolers

    Science.gov (United States)

    Karpinski, Aryn C.; Scullin, Matthew H.

    2009-01-01

    Eighty preschoolers, ages 3 to 5 years old, completed a 4-phase study in which they experienced a live event and received a pressured, suggestive interview about the event a week later. Children were also administered batteries of theory of mind and executive function tasks, as well as the Video Suggestibility Scale for Children (VSSC), which…

  5. Understanding Lustre Internals

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Feiyi [ORNL; Oral, H Sarp [ORNL; Shipman, Galen M [ORNL; Drokin, Oleg [ORNL; Wang, Di [ORNL; Huang, He [ORNL

    2009-04-01

    Lustre was initiated and funded, almost a decade ago, by the U.S. Department of Energy (DoE) Office of Science and National Nuclear Security Administration laboratories to address the need for an open source, highly-scalable, high-performance parallel filesystem on by then present and future supercomputing platforms. Throughout the last decade, it was deployed over numerous medium-to-large-scale supercomputing platforms and clusters, and it performed and met the expectations of the Lustre user community. As it stands at the time of writing this document, according to the Top500 list, 15 of the top 30 supercomputers in the world use Lustre filesystem. This report aims to present a streamlined overview on how Lustre works internally at reasonable details including relevant data structures, APIs, protocols and algorithms involved for Lustre version 1.6 source code base. More importantly, it tries to explain how various components interconnect with each other and function as a system. Portions of this report are based on discussions with Oak Ridge National Laboratory Lustre Center of Excellence team members and portions of it are based on our own understanding of how the code works. We, as the authors team bare all responsibilities for all errors and omissions in this document. We can only hope it helps current and future Lustre users and Lustre code developers as much as it helped us understanding the Lustre source code and its internal workings.

  6. Understanding the role of mirror neurons in action understanding will require more than a domain-general account.

    Science.gov (United States)

    Martin, Alia; Santos, Laurie R

    2014-04-01

    Cook et al. propose that mirror neurons emerge developmentally through a domain-general associative mechanism. We argue that experience-sensitivity does not rule out an adaptive or genetic argument for mirror neuron function, and that current evidence suggests that mirror neurons are more specialized than the authors' account would predict. We propose that future work integrate behavioral and neurophysiological techniques used with primates to examine the proposed functions of mirror neurons in action understanding.

  7. Taenia solium: current understanding of laboratory animal models of taeniosis.

    Science.gov (United States)

    Flisser, A; Avila, G; Maravilla, P; Mendlovic, F; León-Cabrera, S; Cruz-Rivera, M; Garza, A; Gómez, B; Aguilar, L; Terán, N; Velasco, S; Benítez, M; Jimenez-Gonzalez, D E

    2010-03-01

    Neurocysticercosis is a public health problem in many developing countries and is the most frequent parasitic disease of the brain. The human tapeworm carrier is the main risk factor for acquiring neurocysticercosis. Since the parasite lodges only in the human intestine, experimental models of Taenia solium taeniosis have been explored. Macaques, pigs, dogs, cats and rabbits are unsuccessful hosts even in immunodepressed status. By contrast, rodents are adequate hosts since tapeworms with mature, pregravid and, in some cases, gravid proglottids develop after infection. In this review, information that has been generated with experimental models of taeniosis due to T. solium is discussed. Initially, the use of the model for immunodiagnosis of human taeniosis and evaluation of intervention measures is summarized. Next, descriptions of tapeworms and comparison of hamsters, gerbils and other mammals as experimental models are discussed, as well as data on the humoral immune response, the inflammatory reaction and the production of cytokines associated to Th1 and Th2 responses in the intestinal mucosa. Finally, evaluation of protection induced against the development of tapeworms by recombinant T. solium calreticulin in hamsters is summarized and compared to other studies.

  8. Athlete Leadership in Sport Teams: Current Understanding and Future Directions.

    OpenAIRE

    Cotterill, Stewart; Fransen, Katrien

    2016-01-01

    Leadership is a fundamental aspect of sports performance, particularly within team sport environments. Over the past 25 years there has been significant research exploring the role of the coach/manager in this regard. However, this only represents one aspect of leadership within the sporting domain. Equally important, although far less examined is the concept of athlete leadership.\\ud The role of athlete leaders, both formal (e.g., the captain) and informal (such as motivators and cultural ar...

  9. Understanding the Current 30-Year Shipbuilding Plan Through Three Models

    Science.gov (United States)

    2014-12-01

    combatants during the 2030 ’s (Deputy Chief of Naval Operations (Integration of Capabilities and Resources)(N8), 2013). Though this move was ultimately...submarine service’s agenda . In a simple, one-page article, two authors argue that the SSBN program can help “guarantee our very existence, deterring...aided the submarine agenda in the push to build more even in a tight fiscal environment. But there is another organizational factor at play for

  10. Current issues in the understanding of consumer food choice

    DEFF Research Database (Denmark)

    Grunert, Klaus G.

    2002-01-01

    Consumer food choice is framed in terms of the formation of quality expectations before and quality experience after the purchase. For the formation of quality expectations, lack of consumer ability to form expectations that will be predictive of later experience is mentioned as a problem......, and brands and labels are mentioned as possible ways to improve this situation. Genetic modification is used as an example of the way in which consumer attitudes to product technologies can influence quality perceptions and food choice. Food quality is to an increasing extent characterised by so...

  11. Current understanding of rheumatoid arthritis therapy in pregnancy

    Directory of Open Access Journals (Sweden)

    Sujata Swain

    2016-10-01

    Full Text Available Pregnancy in most cases is associated with remission of rheumatoid arthritis (RA, but a quarter of patients continue to have active disease or even worsening of the disease and most patients who improve, relapse in the postpartum period. Patients with RA do not have decreased fertility. A majority of patients with RA may go in remission, but patients who continue with the disease activity require treatment. Drugs that may be safely used during pregnancy include NSAIDs except in third trimester, corticosteroids as low dose prednisone. The preferred disease-modifying agents (DMARDs, during pregnancy are sulfasalazine and hydroxychloroquine. Azathioprine and cyclosporine can be used if the benefits outweigh the risks. Methotrexate and lefunomide are contraindicated and must be prophylactically withdrawn before a planned pregnancy. Biologics like anti-TNF agents, rituximab and abatacept generally should be stopped when pregnancy is discovered. An overall rational approach is highly warranted to treat RA during pregnancy. [Int J Reprod Contracept Obstet Gynecol 2016; 5(10.000: 3275-3279

  12. Understanding Current and Future Issues in Collaborative Consumption

    DEFF Research Database (Denmark)

    Barnes, Stuart; Mattsson, Jan

    2016-01-01

    collaborative consumption. Sustainability is often cited as a key driver, underpinned by economic, social and environmental benefits. If successful, the sharing of such resources is likely to have a potentially disruptive impact on incumbents in traditional supply chains. However, given the embryonic state...... in collaborative consumption over the next 10 years. A key finding was that environmental concern (sustainability) was considered of minor importance. The paper rounds-off with conclusions and implications for practice and further research....

  13. Depression in Parkinson Disease: Current Understanding and Treatment

    Directory of Open Access Journals (Sweden)

    Pei-Hao Chen

    2008-12-01

    Full Text Available Depression has a negative impact on activities of daily living, cognitive performance, and quality of life. Despite the high prevalence of depressive symptoms in Parkinson disease (PD, this important clinical feature is under-recognized by physicians. Effective diagnosis, assessment and treatment of depression are, therefore, important aspects of PD management. In this article, we review the literature concerning depression associated with PD, paying specific attention to clinical presentation, diagnosis, etiology, and the principles of management and treatment. The efficacy and safety of antidepressants must rely on empiric assessments of known risks and putative benefits to guide treatment decisions.

  14. Current issues in the understanding of consumer food choice

    DEFF Research Database (Denmark)

    Grunert, Klaus G.

    2002-01-01

    Consumer food choice is framed in terms of the formation of quality expectations before and quality experience after the purchase. For the formation of quality expectations, lack of consumer ability to form expectations that will be predictive of later experience is mentioned as a problem......, and brands and labels are mentioned as possible ways to improve this situation. Genetic modification is used as an example of the way in which consumer attitudes to product technologies can influence quality perceptions and food choice. Food quality is to an increasing extent characterised by so......-called credence qualities - qualities which are invisible to the consumer both before and after the purchase. Such qualities provide a challenge for communication about the product, not only to induce consumers to buy the product, but also to reinforce their choice after the purchase. Concerning experienced...

  15. Understanding Current and Future Issues in Collaborative Consumption

    DEFF Research Database (Denmark)

    Barnes, Stuart; Mattsson, Jan

    2016-01-01

    collaborative consumption. Sustainability is often cited as a key driver, underpinned by economic, social and environmental benefits. If successful, the sharing of such resources is likely to have a potentially disruptive impact on incumbents in traditional supply chains. However, given the embryonic state...... in collaborative consumption over the next 10 years. A key finding was that environmental concern (sustainability) was considered of minor importance. The paper rounds-off with conclusions and implications for practice and further research....

  16. Current understanding of divertor detachment: experiments and modelling

    Energy Technology Data Exchange (ETDEWEB)

    Wischmeier, W; Groth, M; Kallenbach, A; Chankin, A; Coster, D; Dux, R; Herrmann, A; Muller, H; Pugno, R; Reiter, D; Scarabosio, A; Watkins, J; Team, T D; Team, A U

    2008-05-23

    A qualitative as well as quantitative evaluation of experimentally observed plasma parameters in the detached regime proves to be difficult for several tokamaks. A series of ohmic discharges have been performed in ASDEX Upgrade and DIII-D at similar as possible plasma parameters and at different line averaged densities, {bar n}{sub e}. The experimental data represent a set of well diagnosed discharges against which numerical simulations are compared. For the numerical modeling the fluid-code B2.5 coupled to the Monte Carlo neutrals transport code EIRENE is used. Only the combined enhancement of effects, such as geometry, drift terms, neutral conductance, increased radial transport and divertor target composition, explains a significant fraction of the experimentally observed asymmetries of the ion fluxes as a function of {bar n}{sub e} to the inner and outer target plates in ASDEX Upgrade. The relative importance of the mechanisms leading to detachment are different in DIII-D and ASDEX Upgrade.

  17. Understanding Current and Future Issues in Collaborative Consumption:

    DEFF Research Database (Denmark)

    Mattsson, Jan; Barnes, Stuart

    2016-01-01

    collaborative consumption. Sustainability is often cited as a key driver, underpinned by economic, social and environmental benefits. If successful, the sharing of such resources is likely to have a potentially disruptive impact on incumbents in traditional supply chains. However, given the embryonic state...

  18. [Current understanding of sleep, dreaming and related memory consolidation].

    Science.gov (United States)

    Han, Victor Z; Shi, Jun-Han

    2013-12-01

    Sleep is a naturally recurring state found throughout the animal kingdom and characterized by a reversible loss of consciousness. Although in humans the daily amount of sleep decreases with aging, the total amount of time spent for sleep is estimated as up to one-third of one's lifetime. In mammals, sleep shows a clear daily rhythmicity as well as nightly phases, which are strongly controlled by the circadian clock located in the hypothalamic suprachiasmatic nuclei and are also regulated by ambient light. While it is certain that sleep is critical for survival in general, the functional significance of sleep is still under investigation. Dreaming is a common psychological phenomenon occurring during human sleep, yet its content and natural function, if any, are still a matter of debate. In recent years, accumulated evidence strongly supports the notion that new information acquired during the day time is processed and transformed into long-term memory in a complicated and sophisticated way during sleeping. Such information processing is commonly referred to as memory consolidation.

  19. Catatonia: Our current understanding of its diagnosis, treatment and pathophysiology

    OpenAIRE

    Rasmussen, Sean A; Mazurek, Michael F.; Rosebush, Patricia I.

    2016-01-01

    Catatonia is a psychomotor syndrome that has been reported to occur in more than 10% of patients with acute psychiatric illnesses. Two subtypes of the syndrome have been identified. Catatonia of the retarded type is characterized by immobility, mutism, staring, rigidity, and a host of other clinical signs. Excited catatonia is a less common presentation in which patients develop prolonged periods of psychomotor agitation. Once thought to be a subtype of schizophrenia, catatonia is now recogni...

  20. Pain and sex hormones: a review of current understanding.

    Science.gov (United States)

    Maurer, Adrian J; Lissounov, Alexei; Knezevic, Ivana; Candido, Kenneth D; Knezevic, Nebojsa Nick

    2016-01-01

    Multiple epidemiologic studies have demonstrated an increased prevalence for women in several chronic pain disorders. Clinical and experimental investigations have consistently demonstrated sex-specific differences in pain sensitivity and pain threshold. Even though the underlying mechanisms responsible for these differences have not yet been elucidated, the logical possibility of gonadal hormone influence on nociceptive processing has garnered recent attention. In this review, we evaluated the complex literature regarding gonadal hormones and their influence on pain perception. We reviewed the numerous functions of gonadal hormones, discussed the influence of these hormones on several common chronic pain syndromes (migraine, tension and cluster headaches, fibromyalgia, temporomandibular syndrome, rheumatoid arthritis and back pain, among others), and have attempted to draw conclusions from the available data.

  1. Current understanding of increased insulin sensitivity after exercise - emerging candidates

    DEFF Research Database (Denmark)

    Maarbjerg, Stine Just; Sylow, Lykke; Richter, Erik

    2011-01-01

    insulin sensitivity. It is believed that increased sarcolemmal content of the glucose transporter GLUT4 can explain the phenomenon to some extent. Surprisingly no improvement in the proximal insulin signaling pathway is observed at the level of the insulin receptor, IRS1, PI3K or Akt. Recently more distal...... signaling component in the insulin signaling pathway such as aPKC, Rac1, TBC1D4 and TBC1D1 have been described. These are all affected by both insulin and exercise which means that they are likely converging points in promoting GLUT4 translocation and therefore possible candidates for regulating insulin...... in signaling to GLUT4 translocation, factors influencing the trans-sarcolemmal glucose concentration gradient might also be important. With regard to the interstitial glucose concentration microvascular perfusion is particular relevant as correlative evidence supports a connection between insulin sensitivity...

  2. Current understanding of the pseudospin symmetry in atomic nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Marcos, S; Niembro, R [Departamento de Fisica Moderna, Universidad de Cantabria, E-39005 Santander (Spain); Lopez-Quelle, M [Departamento de Fisica Aplicada, Universidad de Cantabria, E-39005 Santander (Spain); Savushkin, L N [Department of Physics, St. Petersburg University for Telecommunications, 191065 St. Petersburg (Russian Federation)], E-mail: narcoss@unican.es

    2008-08-15

    We use the relativistic mean field framework to analyse the reliability of the explanation of the pseudospin symmetry (PSS) that has been accepted, quite generally, by the scientific community, in the last decade. We make a comparative analysis of the mechanisms responsible for the breaking of the spin and pseudospin symmetries that shows the different nature of these symmetries. We propose an explanation of the PSS, also valid in the nonrelativistic limit, in which the effect of the deviation of the single-particle central potential from a harmonic oscillator on the breaking of the degeneracy of pseudospin doublets is partially compansated by the effect of the spin-orbit interaction.

  3. Perinatal pathology: practice suggestions for limited-resource settings.

    Science.gov (United States)

    Roberts, Drucilla J

    2013-06-01

    The practice of perinatal pathology in much of the world suffers, as do all subspecialties of anatomic pathology, from inadequate resources (equipment, consumables, and both professional and technical personnel), from lack of education (not only of the pathologist but also of the clinicians responsible for sending the specimens, and the technicians processing the specimens), and from lack of appropriate government sector support. Perinatal pathology has significant public health-related utility and should be championing its service by providing maternal and fetal/infant mortality and morbidity data to governmental health ministries. It is with this pathologic data that informed decisions can be made on health-related courses of action and allocation of resources. These perinatal pathology data are needed to develop appropriate public health initiatives, specifically toward achieving the Millennium Developmental Goals as the best way to effectively decrease infant and maternal deaths and to determine causes of perinatal mortality and morbidity. The following overview will focus on the utility of perinatal pathology specifically as related to its public health function and will suggest methods to improve its service in resource-poor settings. This article is offered not as a critique of the current practice that most pathologists find themselves working in globally, but to provide suggestions for improving perinatal pathology services, which could be implemented with the limited available resources and manpower most pathology departments currently have. In addition, we offer suggestions for graded improvements ("ramping up") over time.

  4. Meson exchange and neutral weak currents

    Energy Technology Data Exchange (ETDEWEB)

    Beck, D.H. [Univ. of Illinois, Urbana, IL (United States)

    1994-04-01

    Measurements of parity-violating electron scattering asymmetries to determine weak neutral currents in nuclei will be effected by the presence of meson exchange currents. Present low momentum transfer calculations, based on a flavor independent framework, show these effects to be small. In general, however, as the momentum transfer increases to values typical of deep-inelastic scattering, fragmentation functions show a clear flavor dependence. It is suggested that a good experimental starting point for understanding the flavor dependence of meson production and exchange currents is the Q{sup 2} dependence of parity-violating asymmetry in inclusive single pion electroproduction. A CEBAF facility with doubled energy is necessary to approach momentum transfers where this process begins to scale.

  5. Understanding Blood Counts

    Science.gov (United States)

    ... Lab and Imaging Tests Understanding Blood Counts Understanding Blood Counts Understanding Blood Counts SHARE: Print Glossary Blood cell counts give ... your blood that's occupied by red cells. Normal Blood Counts Normal blood counts fall within a range ...

  6. Current titles

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    This booklet is published for those interested in current research being conducted at the National Center for Electron Microscopy. The NCEM is a DOE-designated national user facility and is available at no charge to qualified researchers. Access is controlled by an external steering committee. Interested researchers may contact Gretchen Hermes at (510) 486-5006 or address below for a User`s Guide. Copies of available papers can be ordered from: Theda Crawford National Center for Electron Microscopy, Lawrence Berkeley Laboratory, One Cyclotron Rd., MS72, Berkeley, California, USA 94720.

  7. On current trace problem

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The pricing of electricity trasmission requires determining how much use each generator is making of a transmission line and what is each generator's contribution to the system losses. Such problems cannot be solved by only using Kirchoff's laws. This paper proposes two current decomposition axioms based on which the theories and models are established for the current trace problem. To create an efficient algorithm the graph theory is employed. It is proved that there is no directed circuit in a directed current distribution graph. According to this theorem a very simple and efficient algorithm based on recursive elimination process is suggested. A simple example is used to explain the algorithm.

  8. Mentalization and social understanding

    DEFF Research Database (Denmark)

    Køster, Allan

    2015-01-01

    Recently, mentalization theory (Fonagy, Bateman) has risen to fame as a theoretical framework emphasizing social cognition as a key issue in its approach to psychotherapy and psychopathology. In this paper, I review and criticise the social-ontological assumptions made by mentalization theory......, the works of Merleau-Ponty, as well as contemporary phenomenology and enactivism (S. Gallagher, D. Hutto etc.). Since mentalization theory was originally developed as a framework for understanding Borderline Personality Disorder, the article furthermore offers a reinterpretation of the issue of social...... cognition reported in BPD through the lens of the alternative framework. Contrary to the received view, the article suggest that issues of social cognition in BPD should perhaps not be seen as primarily a lack of, or inability to mentalize, but rather as a hyper-sensitivity to the expressive dimension...

  9. Current ornithology

    CERN Document Server

    1983-01-01

    The appearance of the first volume of a projected series is the occasion for comment on scope, aims, and genesis of the work. The scope of Current Ornithology is all of the biology of birds. Ornithology, as a whole-organism science, is concerned with birds at every level of bi­ ological organization, from the molecular to the community, at least from the Jurassic to the present time, and over every scholarly discipline in which bird biology is done; to say this is merely to expand a dic­ tionary definition of "ornithology. " The aim of the work, to be realized over several volumes, is to present reviews or position statements con­ cerning the active fields of ornithological research. The reviews will be relatively short, and often will be done from the viewpoint of a readily­ identified group or school. Such a work could have come into being at any time within the past fifty years, but that Current Ornithology appears now is a result of events that are only seven to eight years old. One important event wa...

  10. Are You Suggesting That's My Hand? The Relation Between Hypnotic Suggestibility and the Rubber Hand Illusion.

    Science.gov (United States)

    Walsh, E; Guilmette, D N; Longo, M R; Moore, J W; Oakley, D A; Halligan, P W; Mehta, M A; Deeley, Q

    2015-01-01

    Hypnotic suggestibility (HS) is the ability to respond automatically to suggestions and to experience alterations in perception and behavior. Hypnotically suggestible participants are also better able to focus and sustain their attention on an experimental stimulus. The present study explores the relation between HS and susceptibility to the rubber hand illusion (RHI). Based on previous research with visual illusions, it was predicted that higher HS would lead to a stronger RHI. Two behavioral output measures of the RHI, an implicit (proprioceptive drift) and an explicit (RHI questionnaire) measure, were correlated against HS scores. Hypnotic suggestibility correlated positively with the implicit RHI measure contributing to 30% of the variation. However, there was no relation between HS and the explicit RHI questionnaire measure, or with compliance control items. High hypnotic suggestibility may facilitate, via attentional mechanisms, the multisensory integration of visuoproprioceptive inputs that leads to greater perceptual mislocalization of a participant's hand. These results may provide insight into the multisensory brain mechanisms involved in our sense of embodiment.

  11. Beyond consent--improving understanding in surgical patients.

    LENUS (Irish Health Repository)

    Mulsow, Jürgen J W

    2012-01-01

    Little is known of the actual understanding that underlies patient choices with regard to their surgical treatment. This review explores current knowledge of patient understanding and techniques that may be used to improve this understanding.

  12. Understanding the Impact of Leadership in Nigeria

    Directory of Open Access Journals (Sweden)

    Nichodemus O. Ejimabo

    2013-06-01

    Full Text Available This critical ethnographic study focused on identifying the leadership practices of past and present leaders involved in the operation of the Nigerian government, with emphasis on the Eastern Region. The author was committed and determined to discovering a pattern of meaning through its natural setting, was equally interested in the process rather than outcomes, in context rather than specific variables, and in discovery rather than confirmation in order to gain in-depth knowledge and understanding of the issues and problems associated with the leadership situation in the country. For clarity, the investigator used Northouse leadership approach to understand the leadership in the current Nigerian leadership situation. Twelve past and present leaders in the government operations of the Eastern Region of Nigeria participated in the study, and the leadership assessment instrument survey questionnaire was used to support the study. While the study showed a great need for change in leadership, the results of the study revealed that most of the leaders and policy makers in the Eastern Region of the country lack effective leadership skills for the positions they hold. The study also suggested some recommendations for improving the current leadership situation in Nigeria.

  13. Should Authors be Requested to Suggest Peer Reviewers?

    Science.gov (United States)

    Teixeira da Silva, Jaime A; Al-Khatib, Aceil

    2017-02-02

    As part of a continuous process to explore the factors that might weaken or corrupt traditional peer review, in this paper, we query the ethics, fairness and validity of the request, by editors, of authors to suggest peer reviewers during the submission process. One of the reasons for the current crisis in science pertains to a loss in trust as a result of a flawed peer review which is by nature biased unless it is open peer review. As we indicate, the fact that some editors and journals rely on authors' suggestions in terms of who should peer review their paper already instills a potential way to abuse the trust of the submission and publishing system. An author-suggested peer reviewer choice might also tempt authors to seek reviewers who might be more receptive or sympathetic to the authors' message or results, and thus favor the outcome of that paper. Authors should thus not be placed in such a potentially ethically compromising situation, especially as a mandatory condition for submission. However, the fact that they do not have an opt-out choice during the submission process-especially when using an online submission system that makes such a suggestion compulsory-may constitute a violation of authors' rights.

  14. Public opinion and organ donation suggestions for overcoming barriers.

    Science.gov (United States)

    Cantarovich, Félix

    2005-01-01

    Getting organs for transplantation depends on people's decision; thus, public opinion is essential to finding a solution to this problem. Efforts to improve organ shortage focus on: 1) Living, unrelated donation, 2) increasing marginal donors and 3) proposing economic support for donors. Paradoxically, no initiative has been suggested to modify public opinion towards cadaver donors. Several reasons explain the resistance to donating cadaver organs: Lack of awareness, religious uncertainties, distrust of medicine, hostility to new ideas, and misinformation. Education should be used to reshape public opinion about the use of organs for transplantation. Society should accept that "using" body parts is moral and offers a source of health for everybody. The concept that using cadaver organs implies sharing a source of health might be a social agreement between all members of Society. Suggestions for improving organ shortage include: 1) Society should understand that during one's life one may be just as easily a potential organ receiver as one is an organ donor. 2) Cadaver organs are an irreplaceable source of health. 3) As self-interest is one obstacle to donating cadaver organs, the "concept that allowing the use of our organs after death represents a chance of sharing health for everybody" may be useful for a change of attitude. Even though a poll among transplant professionals supported this suggestion, an international public survey should be carried out to evaluate people's reaction to this message.

  15. Decomposing the Current

    DEFF Research Database (Denmark)

    Hansen, Tim

    The field of molecular electronics have been shown to span a huge range of properties. In an effort to extract the parameters of the system that governs these properties, a number of methods that decomposes the current have been developed. These methods function not just as tools for data...... extraction, but also serves as the foundation upon which to gain insights into the physics that governs the molecular properties. As such, the understanding of the applicability and the development of new methods to decompose the current may be a goal in it self. In this thesis we will explore some...... of these methods, and use the insights from this study to develop new methods. First, we will compare two methods that decompose the current into the transmission from a single conducting level of the molecular device, by extracting level position and broadening. In general we see that the method that relies on I...

  16. Decomposing the Current

    DEFF Research Database (Denmark)

    Hansen, Tim

    The field of molecular electronics have been shown to span a huge range of properties. In an effort to extract the parameters of the system that governs these properties, a number of methods that decomposes the current have been developed. These methods function not just as tools for data...... extraction, but also serves as the foundation upon which to gain insights into the physics that governs the molecular properties. As such, the understanding of the applicability and the development of new methods to decompose the current may be a goal in it self. In this thesis we will explore some...... of these methods, and use the insights from this study to develop new methods. First, we will compare two methods that decompose the current into the transmission from a single conducting level of the molecular device, by extracting level position and broadening. In general we see that the method that relies on I...

  17. Recognising and understanding Lyme disease.

    Science.gov (United States)

    Pearson, Sandra

    2014-09-09

    Lyme disease is the most common vector-borne disease in the northern hemisphere and its incidence is rising, leading to increased public health concerns. It is important to understand the nature of the disease because this defines the limitations of current understanding and knowledge. Significant uncertainties in diagnostics and treatment remain. There is an important role for the nurse in raising awareness, giving advice on prevention and correct tick removal, and in recognising signs of Lyme disease to assist access to prompt medical attention. Increased awareness, further research, improved diagnostics and advances in therapeutics are urgently required.

  18. Molecular spectroscopic study for suggested mechanism of chrome tanned leather

    Science.gov (United States)

    Nashy, Elshahat H. A.; Osman, Osama; Mahmoud, Abdel Aziz; Ibrahim, Medhat

    2012-03-01

    Collagen represents the structural protein of the extracellular matrix, which gives strength of hides and/or skin under tanning process. Chrome tan is the most important tanning agent all over the world. The methods for production of leather evolved over several centuries as art and engineering with little understanding of the underlying science. The present work is devoted to suggest the most probable mechanistic action of chrome tan on hide proteins. First the affect of Cr upon hide protein is indicated by the studied mechanical properties. Then the spectroscopic characterization of the hide protein as well as chrome tanned leather was carried out with Horizontal Attenuated Total Reflection (HATR) FT-IR. The obtained results indicate how the chromium can attached with the active sites of collagen. Molecular modeling confirms that chromium can react with amino as well as carboxylate groups. Four schemes were obtained to describe the possible interactions of chrome tan with hide proteins.

  19. Relating Paleoclimate Data and Past Temperature Gradients: Some Suggestive Rules

    Science.gov (United States)

    Rind, David

    1999-01-01

    Understanding tropical sensitivity is perhaps the major concern confronting researchers, for both past and future climate change issues. Tropical data has been beset by contradictions, and many techniques applicable to the extratropics are either unavailable or fraught with uncertainty when applied at low latitudes. Paleoclimate data, if interpreted within the context of the latitudinal temperature gradient data they imply, can be used to estimate what happened to tropical temperatures in the past, and provide a first guess for what might happen in the future. The approach is made possible by the modeling result that atmospheric dynamical changes, and the climate impacts they produce, respond primarily to temperature gradient changes. Here we review some "rules" obtained from GCM (General Circulation Model) experiments with different sea surface temperature gradients and different forcing, that can be used to relate paleoclimate reconstructions to the likely temperature gradient changes they suggest.

  20. Valuation of Understanding

    DEFF Research Database (Denmark)

    Wiberg, Merete

    An important aim for the teacher in Higher Education is that students, in order to learn, achieve understanding in terms of being able to handle knowledge in a certain way. In this paper focus will be on understanding as a phenomenon which is permeated with values of what good understanding might...... be. Understanding is to be discussed as a phenomenon which in its definition is relative to the paradigm of educational thinking in which it is embedded. Paradigms of valuation of understanding in higher education will be viewed from two perspectives: An anglosaxon curriculum studies tradition...... and a Central and Northern European ‘didaktik' tradition.  The thesis is that understanding within these traditions might be described by different images of understanding movements which express different ideals of structures of understanding. Due to these different ideals of structures of understanding...

  1. Do We Really Understand the Cosmos?

    CERN Document Server

    Padmanabhan, T

    2016-01-01

    Our knowledge about the universe has increased tremendously in the last three decades or so --- thanks to the progress in observations --- but our understanding has improved very little. There are several fundamental questions about our universe for which we have no answers within the current, operationally very successful, approach to cosmology. Worse still, we do not even know how to address some of these issues within the conventional approach to cosmology. This fact suggests that we are missing some important theoretical ingredients in the overall description of the cosmos. I will argue that these issues --- some of which are not fully appreciated or emphasized in the literature --- demand a paradigm shift: We should not think of the universe as described by a specific solution to the gravitational field equations; instead, it should be treated as a special physical system governed by a different mathematical description, rooted in the quantum description of spacetime. I will outline how this can possibly...

  2. The Bransfield Gravity Current

    Science.gov (United States)

    Sangrà, Pablo; Stegner, Alexander; Hernández-Arencibia, Mónica; Marrero-Díaz, Ángeles; Salinas, Carolina; Aguiar-González, Borja; Henríquez-Pastene, Cristian; Mouriño-Carballido, Beatriz

    2017-01-01

    Using in situ data and laboratory experiments, we show that the circulation of the Bransfield Current (BC) around the South Shetland Islands (SSI) may be characterized in terms of a propagating buoyant gravity current. First, we describe the SSI hydrography and some drifter trajectories, paying special attention to the recirculation of the BC at the northeastern tip and northern slopes of the SSI. We observed that when the northeastward-flowing BC reaches the northeastern tip of the SSI, it recirculates around an anticyclonic mesoscale eddy that has not previously been reported in this region. Part of this recirculating water then proceeds southwest along the northern SSI shelf break as a narrow baroclinic jet and another part join the Antarctic Circumpolar Current. Consequently, the cross-slope gradients of properties strengthen, and the southern boundary of the Antarctic Circumpolar Current becomes a nearly submesoscale ( 10 km) front. Second, we compare the observations with buoyant gravity current laboratory experiments in an open basin setup where the SSI topographic barrier is represented by a central wall. The resulting circulation of the buoyant gravity current around the wall mirrors our in situ observations. First, a narrow buoyant gravity current flows northeastward along the southern boundary of the wall. Once the head of the buoyant gravity current reaches the tip of the wall, a recirculating anticyclonic vortex is generated, and the buoyant gravity current then proceeds westward along the north side of the wall. This circulation of the BC around the SSI as a buoyant gravity current may contribute to the fertilization of the waters around the SSI, as suggested by previously reported distributions of nutrients and phytoplankton.

  3. Advances in understanding hypopituitarism

    Science.gov (United States)

    Stieg, Mareike R.; Renner, Ulrich; Stalla, Günter K.; Kopczak, Anna

    2017-01-01

    The understanding of hypopituitarism has increased over the last three years. This review provides an overview of the most important recent findings. Most of the recent research in hypopituitarism has focused on genetics. New diagnostic techniques like next-generation sequencing have led to the description of different genetic mutations causative for congenital dysfunction of the pituitary gland while new molecular mechanisms underlying pituitary ontogenesis have also been described. Furthermore, hypopituitarism may occur because of an impairment of the distinctive vascularization of the pituitary gland, especially by disruption of the long vessel connection between the hypothalamus and the pituitary. Controversial findings have been published on post-traumatic hypopituitarism. Moreover, autoimmunity has been discussed in recent years as a possible reason for hypopituitarism. With the use of new drugs such as ipilimumab, hypopituitarism as a side effect of pharmaceuticals has come into focus. Besides new findings on the pathomechanism of hypopituitarism, there are new diagnostic tools in development, such as new growth hormone stimulants that are currently being tested in clinical trials. Moreover, cortisol measurement in scalp hair is a promising tool for monitoring cortisol levels over time. PMID:28299199

  4. A Privacy-by-Design Contextual Suggestion System for Tourism

    Directory of Open Access Journals (Sweden)

    Pavlos S. Efraimidis

    2016-05-01

    Full Text Available We focus on personal data generated by the sensors and through the everyday usage of smart devices and take advantage of these data to build a non-invasive contextual suggestion system for tourism. The system, which we call Pythia, exploits the computational capabilities of modern smart devices to offer high quality personalized POI (point of interest recommendations. To protect user privacy, we apply a privacy by design approach within all of the steps of creating Pythia. The outcome is a system that comprises important architectural and operational innovations. The system is designed to process sensitive personal data, such as location traces, browsing history and web searches (query logs, to automatically infer user preferences and build corresponding POI-based user profiles. These profiles are then used by a contextual suggestion engine to anticipate user choices and make POI recommendations for tourists. Privacy leaks are minimized by implementing an important part of the system functionality at the user side, either as a mobile app or as a client-side web application, and by taking additional precautions, like data generalization, wherever necessary. As a proof of concept, we present a prototype that implements the aforementioned mechanisms on the Android platform accompanied with certain web applications. Even though the current prototype focuses only on location data, the results from the evaluation of the contextual suggestion algorithms and the user experience feedback from volunteers who used the prototype are very positive.

  5. Ancient DNA suggests the leading role played by men in the Neolithic dissemination.

    Science.gov (United States)

    Lacan, Marie; Keyser, Christine; Ricaut, François-Xavier; Brucato, Nicolas; Tarrús, Josep; Bosch, Angel; Guilaine, Jean; Crubézy, Eric; Ludes, Bertrand

    2011-11-08

    The impact of the Neolithic dispersal on the western European populations is subject to continuing debate. To trace and date genetic lineages potentially brought during this transition and so understand the origin of the gene pool of current populations, we studied DNA extracted from human remains excavated in a Spanish funeral cave dating from the beginning of the fifth millennium B.C. Thanks to a "multimarkers" approach based on the analysis of mitochondrial and nuclear DNA (autosomes and Y-chromosome), we obtained information on the early Neolithic funeral practices and on the biogeographical origin of the inhumed individuals. No close kinship was detected. Maternal haplogroups found are consistent with pre-Neolithic settlement, whereas the Y-chromosomal analyses permitted confirmation of the existence in Spain approximately 7,000 y ago of two haplogroups previously associated with the Neolithic transition: G2a and E1b1b1a1b. These results are highly consistent with those previously found in Neolithic individuals from French Late Neolithic individuals, indicating a surprising temporal genetic homogeneity in these groups. The high frequency of G2a in Neolithic samples in western Europe could suggest, furthermore, that the role of men during Neolithic dispersal could be greater than currently estimated.

  6. Valuation of Understanding

    DEFF Research Database (Denmark)

    Wiberg, Merete

    be. Understanding is to be discussed as a phenomenon which in its definition is relative to the paradigm of educational thinking in which it is embedded. Paradigms of valuation of understanding in higher education will be viewed from two perspectives: An anglosaxon curriculum studies tradition...... valuation of understanding might be different. The difference between these two paradigms are to be discussed with specific reference to how these different ideas of ideals of structures of understanding might influence valuation of understanding and how valuation of understanding has consequences...

  7. The Role of Motor Experience in Understanding Action Function: The Case of the Precision Grasp

    Science.gov (United States)

    Loucks, Jeff; Sommerville, Jessica A.

    2012-01-01

    Recent evidence suggests adults and infants selectively attend to features of action, such as how a hand contacts an object. The current research investigated whether this bias stems from infants' processing of the functional consequences of grasps: understanding that different grasps afford different future actions. A habituation paradigm…

  8. Desert grassland responses to climate and soil moisture suggest divergent vulnerabilities across the southwestern US

    Science.gov (United States)

    Gremer, Jennifer; Bradford, John B.; Munson, Seth M.; Duniway, Michael C.

    2015-01-01

    Climate change predictions include warming and drying trends, which are expected to be particularly pronounced in the southwestern United States. In this region, grassland dynamics are tightly linked to available moisture, yet it has proven difficult to resolve what aspects of climate drive vegetation change. In part, this is because it is unclear how heterogeneity in soils affects plant responses to climate. Here, we combine climate and soil properties with a mechanistic soil water model to explain temporal fluctuations in perennial grass cover, quantify where and the degree to which incorporating soil water dynamics enhances our ability to understand temporal patterns, and explore the potential consequences of climate change by assessing future trajectories of important climate and soil water variables. Our analyses focused on long-term (20 to 56 years) perennial grass dynamics across the Colorado Plateau, Sonoran, and Chihuahuan Desert regions. Our results suggest that climate variability has negative effects on grass cover, and that precipitation subsidies that extend growing seasons are beneficial. Soil water metrics, including the number of dry days and availability of water from deeper (>30 cm) soil layers, explained additional grass cover variability. While individual climate variables were ranked as more important in explaining grass cover, collectively soil water accounted for 40 to 60% of the total explained variance. Soil water conditions were more useful for understanding the responses of C3 than C4 grass species. Projections of water balance variables under climate change indicate that conditions that currently support perennial grasses will be less common in the future, and these altered conditions will be more pronounced in the Chihuahuan Desert and Colorado Plateau. We conclude that incorporating multiple aspects of climate and accounting for soil variability can improve our ability to understand patterns, identify areas of vulnerability, and

  9. Desert grassland responses to climate and soil moisture suggest divergent vulnerabilities across the southwestern United States.

    Science.gov (United States)

    Gremer, Jennifer R; Bradford, John B; Munson, Seth M; Duniway, Michael C

    2015-11-01

    Climate change predictions include warming and drying trends, which are expected to be particularly pronounced in the southwestern United States. In this region, grassland dynamics are tightly linked to available moisture, yet it has proven difficult to resolve what aspects of climate drive vegetation change. In part, this is because it is unclear how heterogeneity in soils affects plant responses to climate. Here, we combine climate and soil properties with a mechanistic soil water model to explain temporal fluctuations in perennial grass cover, quantify where and the degree to which incorporating soil water dynamics enhances our ability to understand temporal patterns, and explore the potential consequences of climate change by assessing future trajectories of important climate and soil water variables. Our analyses focused on long-term (20-56 years) perennial grass dynamics across the Colorado Plateau, Sonoran, and Chihuahuan Desert regions. Our results suggest that climate variability has negative effects on grass cover, and that precipitation subsidies that extend growing seasons are beneficial. Soil water metrics, including the number of dry days and availability of water from deeper (>30 cm) soil layers, explained additional grass cover variability. While individual climate variables were ranked as more important in explaining grass cover, collectively soil water accounted for 40-60% of the total explained variance. Soil water conditions were more useful for understanding the responses of C3 than C4 grass species. Projections of water balance variables under climate change indicate that conditions that currently support perennial grasses will be less common in the future, and these altered conditions will be more pronounced in the Chihuahuan Desert and Colorado Plateau. We conclude that incorporating multiple aspects of climate and accounting for soil variability can improve our ability to understand patterns, identify areas of vulnerability, and predict

  10. Metaphor, skepticism, understanding Metaphor, skepticism, understanding

    Directory of Open Access Journals (Sweden)

    Helena Martins

    2010-05-01

    Full Text Available

    This paper examines the idea that metaphor is a basic cognitive tool from a Wittgensteinian point of view. One specific aspect of Wittgenstein’s legacy is explored, namely his account of verbal understanding. Two interconnected and notoriously difficult features of this account are highlighted and discussed: the idea that linguistic understanding is not an event or a process, but an “abiding condition” (Philosophical Investigations, §143-84; and the idea that neither the meaning of a linguistic expression nor our understanding of it can ever go beyond our capacity of explaining it (Philosophical Investigations, §75. This perspective is shown to be particularly apt in reflecting upon the virtues of metaphor as a means of understanding, especially because it allows for the avoidance of both essentialist and skeptical accounts.

    This paper examines the idea that metaphor is a basic cognitive tool from a Wittgensteinian point of view. One specific aspect of Wittgenstein’s legacy is explored, namely his account of verbal understanding. Two interconnected and notoriously difficult features of this account are highlighted and discussed: the idea that linguistic understanding is not an event or a process, but an “abiding condition” (Philosophical Investigations, §143-84; and the idea that neither the meaning of a linguistic expression nor our understanding of it can ever go beyond our capacity of explaining it (Philosophical Investigations, §75. This perspective is shown to be particularly apt in reflecting upon the virtues of metaphor as a means of understanding, especially because it allows for the avoidance of both essentialist and skeptical accounts

  11. On the centenary of Charcot: hysteria, suggestibility and hypnosis.

    Science.gov (United States)

    Chertok, L

    1984-06-01

    In studying hysteria by means of hypnosis, Charcot placed emphasis on the psychological aetiology of the neuroses. Among his pupils, Freud alone grasped this epistemological turning-point, from which he made his great discoveries. But hysteria and hypnosis still remain today largely unknown. We have not yet elucidated the 'mysterious leap' between the psychological and the somatic for the former, and between the relational and the instrumental for the latter. While psychoanalysts have constantly concerned themselves with hysteria, they have shown a lack of interest in hypnosis after Freud abandoned its practice. According to Freud, thanks to transference, affect would be controlled by cognition, a viewpoint eminently suited to satisfy his rationalistic outlook. Affect, however, remains an unknown realm. The affective relationship has, at all events, acquired an ever-increasing importance in psychoanalysis during the last few years, with the emphasis on the early mother-child relationship. The 'affective locus' remains the basic, as well as the most obscure, element in the hypno-suggestive relationship. The behaviourist approach, which quantifies the 'vertical' dimension in depth, is a limited one. The study of the 'horizontal' dimension of subjective experience represents a new line of research, which may make it possible to distinguish different forms of hypnosis. The understanding of hypno-suggestion may throw light on psychoanalysis, psychotherapy, and the human sciences in general.

  12. Understanding Dyslexia (For Parents)

    Science.gov (United States)

    ... Feeding Your 1- to 2-Year-Old Understanding Dyslexia KidsHealth > For Parents > Understanding Dyslexia A A A ... be taught to become successful readers. Reading and Dyslexia Most kids begin learning to read by learning ...

  13. Guide to Understanding Lymphedema

    Science.gov (United States)

    ... to Understanding Lymphedema Get Support Guide to Understanding Lymphedema 2015, 5th Edition By: Robin Warshaw, Contributing Writer ... YES NO ADDITIONAL FEEDBACK Home page More In Lymphedema Breast Cancer News August 14, 2013 Extra Weight — ...

  14. Understanding in mathematics

    CERN Document Server

    Sierpinska, Anna

    1994-01-01

    The concept of understanding in mathematics with regard to mathematics education is considered in this volume, the main problem for mathematics teachers being how to facilitate their students'' understanding of the mathematics being taught.

  15. Understanding Dyslexia (For Parents)

    Science.gov (United States)

    ... Feeding Your 1- to 2-Year-Old Understanding Dyslexia KidsHealth > For Parents > Understanding Dyslexia Print A A ... be taught to become successful readers. Reading and Dyslexia Most kids begin learning to read by learning ...

  16. For A Beffer Understanding

    Institute of Scientific and Technical Information of China (English)

    余换林; 邓新华

    2004-01-01

    Nowadays there is often a lack of understanding between our parents and us. Quite a few of us. complain that parents can't understand us while parents feel sorry that children seldom listen to them. Why?

  17. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... find our information on Coping With Cancer helpful. Understanding Statistics About Survival Doctors estimate prognosis by using statistics ... the best position to discuss your prognosis. Survival statistics most ... Understanding the Difference Between Cure and Remission Cure means ...

  18. Declining orangutan encounter rates from Wallace to the present suggest the species was once more abundant.

    Directory of Open Access Journals (Sweden)

    Erik Meijaard

    Full Text Available BACKGROUND: Bornean orangutans (Pongo pygmaeus currently occur at low densities and seeing a wild one is a rare event. Compared to present low encounter rates of orangutans, it is striking how many orangutan each day historic collectors like Alfred Russel Wallace were able to shoot continuously over weeks or even months. Does that indicate that some 150 years ago encounter rates with orangutans, or their densities, were higher than now? METHODOLOGY/PRINCIPAL FINDINGS: We test this hypothesis by quantifying encounter rates obtained from hunting accounts, museum collections, and recent field studies, and analysing whether there is a declining trend over time. Logistic regression analyses of our data support such a decline on Borneo between the mid-19th century and the present. Even when controlled for variation in the size of survey and hunting teams and the durations of expeditions, mean daily encounter rates appear to have declined about 6-fold in areas with little or no forest disturbance. CONCLUSIONS/SIGNIFICANCE: This finding has potential consequences for our understanding of orangutans, because it suggests that Bornean orangutans once occurred at higher densities. We explore potential explanations-habitat loss and degradation, hunting, and disease-and conclude that hunting fits the observed patterns best. This suggests that hunting has been underestimated as a key causal factor of orangutan density and distribution, and that species population declines have been more severe than previously estimated based on habitat loss only. Our findings may require us to rethink the biology of orangutans, with much of our ecological understanding possibly being based on field studies of animals living at lower densities than they did historically. Our approach of quantifying species encounter rates from historic data demonstrates that this method can yield valuable information about the ecology and population density of species in the past, providing new

  19. A review of cyberbullying and suggestions for online psychological therapy

    Directory of Open Access Journals (Sweden)

    Mairéad Foody

    2015-09-01

    Full Text Available Investigations of cyberbullying are beginning to emerge in the scientific literature because of their implications for child and adolescent development. In particular, cyberbullying victimisation has been associated with similar negative consequences to traditional or face-to-face bullying such as lower academic achievement, anxiety, and sometimes even suicide. Research has also started to emerge investigating the impact of such incidences on the life of adults. The literature in this area has been steadily growing over the last decade and this review highlights the current situation in terms of relevant features and the psychological impact on victims. The selection process consisted of a comprehensive search that was conducted in January 2015 in the following databases: PsychInfo, ERIC, Web of Science and Medline. A total of 19 papers were included. We conclude with suggestions for online psychological treatment for victims and bullies as a means of coping with the distress caused from cyberbullying experiences.

  20. Suggestions for Forest Conservation Policy under Climate Change

    Science.gov (United States)

    Choe, H.; Thorne, J. H.; Lee, D. K.; Seo, C.

    2015-12-01

    Climate change and the destruction of natural habitats by land-use change are two main factors in decreasing terrestrial biodiversity. Studying land-use and climate change and their impact under different scenarios can help suggest policy directions for future events. This study explores the spatial results of different land use and climate models on the extent of species rich areas in South Korea. We built land use models of forest conversion and created four 2050 scenarios: (1) a loss trend following current levels, resulting in 15.5% lost; (2) similar loss, but with forest conservation in areas with suitable future climates; (3) a reduction of forest loss by 50%; and (4) a combination of preservation of forest climate refugia and overall reduction of loss by 50%. Forest climate refugia were identified through the use of species distribution models run on 1,031 forest plant species to project current and 2050 distributions. We calculated change in species richness under four climate projections, permitting an assessment of forest refugia zones. We then crossed the four land use models with the climate-driven change in species richness. Forest areas predominantly convert to agricultural areas, while climate-suitable extents for forest plants decline and move northward, especially to higher elevations. Scenario 2, that has the higher level of deforestation but protects future species rich areas, conserves nearly as much future biodiversity as scenario 3, which reduced deforestation rates by 50%. This points to the importance of including biogeographic climate dynamics in forest policy. Scenario 4 was the most effective at conserving forest biodiversity. We suggest conserving forest areas with suitable climates for biodiversity conservation and the establishment of monoculture plantations targeted to areas where species richness will decline based on our results.

  1. Understanding Samurai Disloyalty

    Directory of Open Access Journals (Sweden)

    Joshua Archer

    2008-12-01

    Full Text Available Prevailing notions of samurai loyalty remain largely unopposed by Western scholarly literature. This should not be so. Minor efforts in recent scholarship have plainly shown that the stereotypical notion of samurai loyalty is fallacious. However, despite these assertions the myth remains a powerful and popular misconception. Clearly a greater scholarly undertaking is required. Through an in-depth historical analysis of samurai disloyalty, a more realistic conception of samurai behaviour may be achieved. This article seeks to provide a foundation for further research, arguing that disloyalty was favoured among samurai to further their personal ambitions or interests. Disloyalty between medieval samurai was not always considered morally deplorable, nor was it considered divergent to ‘normal’ samurai behaviour. Moreover, it is erroneous to argue that the majority of samurai were ‘loyal,’ when in fact many were often being coerced or manipulated by those in power. Logic suggests that loyalty must be voluntary, thus the use of coercion undermines assertions of samurai loyalty. Further scholarship should not merely seek to establish the frequency of samurai disloyalty, nor should it condemn such occurrences. It must endeavour to understand how and why disloyalty occurred.

  2. Community-wide assessment of protein-interface modeling suggests improvements to design methodology.

    Science.gov (United States)

    Fleishman, Sarel J; Whitehead, Timothy A; Strauch, Eva-Maria; Corn, Jacob E; Qin, Sanbo; Zhou, Huan-Xiang; Mitchell, Julie C; Demerdash, Omar N A; Takeda-Shitaka, Mayuko; Terashi, Genki; Moal, Iain H; Li, Xiaofan; Bates, Paul A; Zacharias, Martin; Park, Hahnbeom; Ko, Jun-su; Lee, Hasup; Seok, Chaok; Bourquard, Thomas; Bernauer, Julie; Poupon, Anne; Azé, Jérôme; Soner, Seren; Ovali, Sefik Kerem; Ozbek, Pemra; Tal, Nir Ben; Haliloglu, Türkan; Hwang, Howook; Vreven, Thom; Pierce, Brian G; Weng, Zhiping; Pérez-Cano, Laura; Pons, Carles; Fernández-Recio, Juan; Jiang, Fan; Yang, Feng; Gong, Xinqi; Cao, Libin; Xu, Xianjin; Liu, Bin; Wang, Panwen; Li, Chunhua; Wang, Cunxin; Robert, Charles H; Guharoy, Mainak; Liu, Shiyong; Huang, Yangyu; Li, Lin; Guo, Dachuan; Chen, Ying; Xiao, Yi; London, Nir; Itzhaki, Zohar; Schueler-Furman, Ora; Inbar, Yuval; Potapov, Vladimir; Cohen, Mati; Schreiber, Gideon; Tsuchiya, Yuko; Kanamori, Eiji; Standley, Daron M; Nakamura, Haruki; Kinoshita, Kengo; Driggers, Camden M; Hall, Robert G; Morgan, Jessica L; Hsu, Victor L; Zhan, Jian; Yang, Yuedong; Zhou, Yaoqi; Kastritis, Panagiotis L; Bonvin, Alexandre M J J; Zhang, Weiyi; Camacho, Carlos J; Kilambi, Krishna P; Sircar, Aroop; Gray, Jeffrey J; Ohue, Masahito; Uchikoga, Nobuyuki; Matsuzaki, Yuri; Ishida, Takashi; Akiyama, Yutaka; Khashan, Raed; Bush, Stephen; Fouches, Denis; Tropsha, Alexander; Esquivel-Rodríguez, Juan; Kihara, Daisuke; Stranges, P Benjamin; Jacak, Ron; Kuhlman, Brian; Huang, Sheng-You; Zou, Xiaoqin; Wodak, Shoshana J; Janin, Joel; Baker, David

    2011-11-25

    The CAPRI (Critical Assessment of Predicted Interactions) and CASP (Critical Assessment of protein Structure Prediction) experiments have demonstrated the power of community-wide tests of methodology in assessing the current state of the art and spurring progress in the very challenging areas of protein docking and structure prediction. We sought to bring the power of community-wide experiments to bear on a very challenging protein design problem that provides a complementary but equally fundamental test of current understanding of protein-binding thermodynamics. We have generated a number of designed protein-protein interfaces with very favorable computed binding energies but which do not appear to be formed in experiments, suggesting that there may be important physical chemistry missing in the energy calculations. A total of 28 research groups took up the challenge of determining what is missing: we provided structures of 87 designed complexes and 120 naturally occurring complexes and asked participants to identify energetic contributions and/or structural features that distinguish between the two sets. The community found that electrostatics and solvation terms partially distinguish the designs from the natural complexes, largely due to the nonpolar character of the designed interactions. Beyond this polarity difference, the community found that the designed binding surfaces were, on average, structurally less embedded in the designed monomers, suggesting that backbone conformational rigidity at the designed surface is important for realization of the designed function. These results can be used to improve computational design strategies, but there is still much to be learned; for example, one designed complex, which does form in experiments, was classified by all metrics as a nonbinder.

  3. Memorandum of Understanding.

    Energy Technology Data Exchange (ETDEWEB)

    Siple, Bud H. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2014-07-01

    A Memorandum of Understanding establishes a clear understanding of how an agreement is going to be implemented. The Memorandum of Understanding allows all involved to specifically understand that they are agreeing to the same thing and the terms are clearly identified. It also includes the clear distinction of functions and the level of involvement of the agencies involved. Specifically, a Memorandum of Understanding gives a chance to all of those involved in the agreement to see on paper as to what they all have agreed to.

  4. BOOK REVIEW: The Current Comparator

    Science.gov (United States)

    Petersons, Oskars

    1989-01-01

    . One would hardly find a standards laboratory today without an instrument employing a current comparator. The NRC program, now nearing the end of its third decade, has resulted in a large number of papers in technical journals. The fact that the results of the current-comparator program are now documented in a well-written book is a most welcome development. The material in the book is well organized and divided into seven chapters. Chapter 1 deals very briefly with the historical aspects of the development, including related work in other organizations. Chapter 2 is the longest, occupying one third of the book. It presents the background theory; the definitions and origins of the errors; and the related concepts and devices including two-stage current transformers, electronic methods for improving the performance of current transformers, and null detectors. The idea of the current comparator is developed starting from Ampere's law; and then progressing to the practical realization of measuring the line integral of the magnetic field surrounding an electric current. Such an approach, as opposed to the more common methods of analyzing transformers, has a tutorial value in explaining how the current balance is achieved. Such analysis is intuitive for air-core sensing coils with infinitesimal cross-sections and uniform winding densities. The intuitive understanding, however, becomes less obvious when high-permeability magnetic cores are used. The subject of errors is discussed thoroughly. For errors of magnetic origin, ample experimental data are provided to support the hypothesis for the cause of such errors. The cause is discussed in a macroscopic sense (non-uniform effective permeability along the torus) without going into design and processing details which could be responsible for the non-uniformities. For capacitive errors, equations have been developed to compute them from geometrical considerations. Techniques are presented to reduce both types of errors shielding

  5. Understanding individual routing behaviour.

    Science.gov (United States)

    Lima, Antonio; Stanojevic, Rade; Papagiannaki, Dina; Rodriguez, Pablo; González, Marta C

    2016-03-01

    Knowing how individuals move between places is fundamental to advance our understanding of human mobility (González et al. 2008 Nature 453, 779-782. (doi:10.1038/nature06958)), improve our urban infrastructure (Prato 2009 J. Choice Model. 2, 65-100. (doi:10.1016/S1755-5345(13)70005-8)) and drive the development of transportation systems. Current route-choice models that are used in transportation planning are based on the widely accepted assumption that people follow the minimum cost path (Wardrop 1952 Proc. Inst. Civ. Eng. 1, 325-362. (doi:10.1680/ipeds.1952.11362)), despite little empirical support. Fine-grained location traces collected by smart devices give us today an unprecedented opportunity to learn how citizens organize their travel plans into a set of routes, and how similar behaviour patterns emerge among distinct individual choices. Here we study 92 419 anonymized GPS trajectories describing the movement of personal cars over an 18-month period. We group user trips by origin-destination and we find that most drivers use a small number of routes for their routine journeys, and tend to have a preferred route for frequent trips. In contrast to the cost minimization assumption, we also find that a significant fraction of drivers' routes are not optimal. We present a spatial probability distribution that bounds the route selection space within an ellipse, having the origin and the destination as focal points, characterized by high eccentricity independent of the scale. While individual routing choices are not captured by path optimization, their spatial bounds are similar, even for trips performed by distinct individuals and at various scales. These basic discoveries can inform realistic route-choice models that are not based on optimization, having an impact on several applications, such as infrastructure planning, routing recommendation systems and new mobility solutions. © 2016 The Author(s).

  6. Semantic Borders and Incomplete Understanding.

    Science.gov (United States)

    Silva-Filho, Waldomiro J; Dazzani, Maria Virgínia

    2016-03-01

    In this article, we explore a fundamental issue of Cultural Psychology, that is our "capacity to make meaning", by investigating a thesis from contemporary philosophical semantics, namely, that there is a decisive relationship between language and rationality. Many philosophers think that for a person to be described as a rational agent he must understand the semantic content and meaning of the words he uses to express his intentional mental states, e.g., his beliefs and thoughts. Our argument seeks to investigate the thesis developed by Tyler Burge, according to which our mastery or understanding of the semantic content of the terms which form our beliefs and thoughts is an "incomplete understanding". To do this, we discuss, on the one hand, the general lines of anti-individualism or semantic externalism and, on the other, criticisms of the Burgean notion of incomplete understanding - one radical and the other moderate. We defend our understanding that the content of our beliefs must be described in the light of the limits and natural contingencies of our cognitive capacities and the normative nature of our rationality. At heart, anti-individualism leads us to think about the fact that we are social creatures, living in contingent situations, with important, but limited, cognitive capacities, and that we receive the main, and most important, portion of our knowledge simply from what others tell us. Finally, we conclude that this discussion may contribute to the current debate about the notion of borders.

  7. [Intersubjectivity: Between Explanation and Understanding].

    Science.gov (United States)

    Cely Ávila, Flor Emilce

    2014-03-01

    The discussion on explanation and understanding has led to a division in the sciences, based on what is considered to be inherent to each of the domains. The task of the natural sciences would be the explanation, while that of the social sciences would be understanding or interpretation.There is a line of work that currently seeks to overcome the methodological dualism and to propose more interdisciplinary studies, such as the studies on emergence of the mental in the framework of intersubjective relationships. In particular, the concept of intersubjectivity defended by the phenomenology as an embodied practice, is being supported by the results of investigations carried out on the basis of the cognitive neuroscience and developmental psychology. Authors from different roots, such as J. Bruner and S. Gallagher propose considering these types of interdisciplinary collaboration as a possible way to integrate the traditions of the explanation and understanding. The purpose of this paper is to analyze to what extent this collaboration between phenomenology and sciences, particularly on the subject of understanding others and their relevance for the understanding of certain psychopathologies, has allowed to close the gap that had opened in the nineteenth century between these traditions.

  8. On current trace problem

    Institute of Scientific and Technical Information of China (English)

    王锡凡; 王秀丽

    2000-01-01

    The pricing of electricity trasmission requires determining how much use each generator is making of a transmission line and what is each generator’s contribution to the system losses. Such problems cannot be solved by only using Kirchoff’s laws. This paper proposes two current decomposition axioms based on which the theories and models are established for the current trace problem. To create an efficient algorithm the graph theory is employed. It is proved that there is no directed circuit in a directed current distribution graph. According to this theorem a very simple and efficient algorithm based on recursive elimination process is suggested. A simple example is used to explain the algorithm .

  9. Understanding readers' understanding theory to practice

    CERN Document Server

    Tierney, Robert J; Mitchell, Judy Nichols

    2013-01-01

    This collection features papers addressing current issues in reading comprehension from cognitive and linguistic perspectives. Organized into three sections, the volume investigates text considerations and reader-text interactions. Each paper presents a substantial and comprehensive review of theory and research related to cognition and reading comprehension.

  10. Students' understanding of quadratic equations

    Science.gov (United States)

    López, Jonathan; Robles, Izraim; Martínez-Planell, Rafael

    2016-05-01

    Action-Process-Object-Schema theory (APOS) was applied to study student understanding of quadratic equations in one variable. This required proposing a detailed conjecture (called a genetic decomposition) of mental constructions students may do to understand quadratic equations. The genetic decomposition which was proposed can contribute to help students achieve an understanding of quadratic equations with improved interrelation of ideas and more flexible application of solution methods. Semi-structured interviews with eight beginning undergraduate students explored which of the mental constructions conjectured in the genetic decomposition students could do, and which they had difficulty doing. Two of the mental constructions that form part of the genetic decomposition are highlighted and corresponding further data were obtained from the written work of 121 undergraduate science and engineering students taking a multivariable calculus course. The results suggest the importance of explicitly considering these two highlighted mental constructions.

  11. Could a Neuroscientist Understand a Microprocessor?

    Science.gov (United States)

    Jonas, Eric; Kording, Konrad Paul

    2017-01-01

    There is a popular belief in neuroscience that we are primarily data limited, and that producing large, multimodal, and complex datasets will, with the help of advanced data analysis algorithms, lead to fundamental insights into the way the brain processes information. These datasets do not yet exist, and if they did we would have no way of evaluating whether or not the algorithmically-generated insights were sufficient or even correct. To address this, here we take a classical microprocessor as a model organism, and use our ability to perform arbitrary experiments on it to see if popular data analysis methods from neuroscience can elucidate the way it processes information. Microprocessors are among those artificial information processing systems that are both complex and that we understand at all levels, from the overall logical flow, via logical gates, to the dynamics of transistors. We show that the approaches reveal interesting structure in the data but do not meaningfully describe the hierarchy of information processing in the microprocessor. This suggests current analytic approaches in neuroscience may fall short of producing meaningful understanding of neural systems, regardless of the amount of data. Additionally, we argue for scientists using complex non-linear dynamical systems with known ground truth, such as the microprocessor as a validation platform for time-series and structure discovery methods.

  12. Understanding Cancer Prognosis

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  13. Understanding Cancer Prognosis

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    Full Text Available ... Advisory Board Meetings Social Media Events Cancer Currents Blog All Press Releases 2017 2016 2015 2014 2013 ... Conferences Advisory Board Meetings Social Media Cancer Currents Blog About NCI NCI Overview History Contributing to Cancer ...

  14. Understanding Cancer Prognosis

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  15. Understanding Cancer Prognosis

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  16. Understanding Cancer Prognosis

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  17. Understanding Cancer Prognosis

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    Full Text Available ... Media Cancer Currents Blog About NCI NCI Overview History Contributing to Cancer Research Leadership Director's Page Previous ... Information Legislative Activities Hearings & Testimonies Current Congress Legislative History Committees of Interest Legislative Resources Recent Public Laws ...

  18. Understanding Cancer Prognosis

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    Full Text Available ... Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Social Media Events Cancer Currents Blog All Press Releases 2017 ... Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Social Media Cancer Currents Blog About NCI NCI Overview History ...

  19. Understanding Cancer Prognosis

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  20. Understanding Cancer Prognosis

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    Full Text Available ... Events Cancer Currents Blog All Press Releases 2017 2016 2015 2014 2013 2012 Media Resources Media Contacts ... Senior Leadership Director Previous Directors NCI Organization Divisions, Offices & Centers Advisory Boards & Review Groups Budget & Appropriations Current ...

  1. Understanding Cancer Prognosis

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    Full Text Available ... Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Social Media Events Cancer Currents Blog All Press Releases ... Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Social Media Cancer Currents Blog About NCI NCI Overview ...

  2. Understanding Cancer Prognosis

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    Full Text Available ... our information on Coping With Cancer helpful. Understanding Statistics About Survival Doctors estimate prognosis by using statistics that researchers have collected over many years about ...

  3. Understanding Minor Rectal Bleeding

    Science.gov (United States)

    ... Home / For Patients / Patient Information Understanding Minor Rectal Bleeding What are the possible causes of minor rectal bleeding? Hemorrhoids Anal fissures Proctitis (inflammation of the rectum) ...

  4. Understanding Cancer Prognosis

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    Full Text Available ... about Advanced Cancer Research Managing Cancer Care Finding Health Care Services Costs & Medical Information Advance Directives Using Trusted Resources Understanding Cancer What ...

  5. The Chukchi slope current

    Science.gov (United States)

    Corlett, W. Bryce; Pickart, Robert S.

    2017-04-01

    Using a collection of 46 shipboard hydrographic/velocity transects occupied across the shelfbreak and slope of the Chukchi Sea between 2002 and 2014, we have quantified the existence of a current transporting Pacific-origin water westward over the upper continental slope. It has been named the Chukchi slope current, which is believed to emanate from Barrow Canyon. The current is surface-intensified, order 50 km wide, and advects both summer and winter waters. It is not trapped to a particular isobath, but instead is reminiscent of a free jet. There is no significant variation in Pacific water transport with distance from Barrow Canyon. A potential vorticity analysis suggests that the flow is baroclinically unstable, consistent with the notion that it meanders. The current is present during all synoptic wind conditions, but increases in strength from summer to fall presumably due to the seasonal enhancement of the easterly winds in the region. Its transport increased over the 12-year period of data coverage, also likely in response to wind forcing. In the mean, the slope current transports 0.50 ± 0.07 Sv of Pacific water. This estimate allows us to construct a balanced mass budget of the Chukchi shelf inflows and outflows. Our study also confirms the existence of an eastward-flowing Chukchi shelfbreak jet transporting 0.10 ± 0.03 Sv of Pacific water towards Barrow Canyon.

  6. Adolescent idiopathic scoliosis: current perspectives

    Directory of Open Access Journals (Sweden)

    Miyanji F

    2014-01-01

    Full Text Available Firoz MiyanjiBritish Columbia Children's Hospital, Vancouver, BC, CanadaAbstract: Adolescent idiopathic scoliosis (AIS remains a common and potentially severe musculoskeletal disorder. Although its etiology is largely unknown, ongoing research endeavors continue to improve our understanding of its potential origin and its natural history. Advances in understanding its true three-dimensional nature have sought to improve classification and management strategies. This review will attempt to highlight and give an overview of the current concepts in adolescent idiopathic scoliosis.Keywords: AIS, current, natural history, management strategies

  7. Preparing gender inclusive science teachers: Suggestions from the literature

    Science.gov (United States)

    Weinburgh, Molly

    1995-03-01

    It is imperative that the education given to United States children include adequate science taught in a way that will encourage the retention of all students; however, as half the population is female and females are underrepresented in the fields of mathematics and science, it is especially important that females be encouraged in these areas. Teacher education has been challenged to develop programs that produce teachers who understand the need for equitable science classrooms and who have the skills necessary to produce them. Several suggestions have been given for teacher education programs in science. First, college professors must examine their courses for gender bias. They must model equitable classroom strategies by planning activities that encourage the females to become active participants in the learning process and by using language that is gender inclusive. Second, definite instruction should be given to help the preservice and inservice teachers address their own attitudes toward science and children. Third, specific attention must be paid to assessing teachers in the following areas: (a) developing active, inquiry-based instruction; (b) developing classrooms in which constructive talking is the norm; (c) using cooperative groups correctly; (d) decreasing stereotyping of males, females, and scientists; and (e) using language that is gender inclusive.

  8. Function of Hexagenia (Mayfly) Burrows: Fluid Model Suggests Bacterial Gardening

    Science.gov (United States)

    Traynham, B.; Furbish, D.; Miller, M.; White, D.

    2006-12-01

    Lake and stream bottoms experience an array of physical, chemical, and biological processes that create spatial variations both in the fluid column and in the sediment that provide a physical template for distinct niches. Burrowing insects are major ecological engineers of communities where they structure large areas of the benthic habitat through bioturbation and other activities including respiration, feeding, and defecation. The burrowing mayfly Hexagenia, when present in high densities, has a large impact on food-web dynamics and provides essential ecosystem services within the fluid column and benthic substrate, including sediment mixing, nutrient cycling, and ultimately, energy flow through the freshwater food web. It has long been recognized that particular benthic species are important in linking detrital energy resources to higher trophic levels and for determining how organic matter is processed in freshwater ecosystems; however, the unique contributions made by individual benthic species is largely absent from the literature. Here we present a model that describes the structure and function of a Hexagenia burrow. If testing supports this hypothesis, the model suggests that when high food concentration is available to Hexagenia, there exists a favorable tube length for harvesting bacteria that grow on the burrow walls. The burrow microhabitat created by Hexagenia serves as a case-study in understanding the influence of benthic burrowers on both energy flow through freshwater food webs and nutrient cycling.

  9. Against over-interpretation: the understanding of pain amongst Turkish and Kurdish speakers in London.

    Science.gov (United States)

    Yazar, J; Littlewood, R

    2001-01-01

    The understanding of experienced pain has recently moved from the biological to the metaphorical. Detailed interviews with twelve Turkish and Kurdish patients in London who had been unsuccessfully investigated medically for chronic pain showed that their understanding reflected local, typically humoural, conceptions of self and body. However there was little to suggest interpretation of the illness as a more specific and grounded idiom for social or political experience. It is suggested that the current vogue for 'interpretation' in medical anthropology and social psychiatry may occasionally be, as Umberto Eco puts it, 'over-interpretation'.

  10. Enhances the crew to understand AIS some suggestions%提高船员了解AIS的一些建议

    Institute of Scientific and Technical Information of China (English)

    刘先杰; 钟碧良

    2007-01-01

    目前许多船舶己装备了AIS,本文通过对船员进行问卷调查,归纳总结出船员实际了解和使用AIS时存在的不足,提出一些切实可行的建议,以期普及船员AIS的知识,最大限度地发挥AIS的效能.

  11. Current challenges in autonomous vehicle development

    Science.gov (United States)

    Connelly, J.; Hong, W. S.; Mahoney, R. B., Jr.; Sparrow, D. A.

    2006-05-01

    The field of autonomous vehicles is a rapidly growing one, with significant interest from both government and industry sectors. Autonomous vehicles represent the intersection of artificial intelligence (AI) and robotics, combining decision-making with real-time control. Autonomous vehicles are desired for use in search and rescue, urban reconnaissance, mine detonation, supply convoys, and more. The general adage is to use robots for anything dull, dirty, dangerous or dumb. While a great deal of research has been done on autonomous systems, there are only a handful of fielded examples incorporating machine autonomy beyond the level of teleoperation, especially in outdoor/complex environments. In an attempt to assess and understand the current state of the art in autonomous vehicle development, a few areas where unsolved problems remain became clear. This paper outlines those areas and provides suggestions for the focus of science and technology research. The first step in evaluating the current state of autonomous vehicle development was to develop a definition of autonomy. A number of autonomy level classification systems were reviewed. The resulting working definitions and classification schemes used by the authors are summarized in the opening sections of the paper. The remainder of the report discusses current approaches and challenges in decision-making and real-time control for autonomous vehicles. Suggested research focus areas for near-, mid-, and long-term development are also presented.

  12. Understanding Cancer Prognosis

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  13. Understanding Cancer Prognosis

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  14. Understanding cancer onset

    DEFF Research Database (Denmark)

    Veldhuis, Djuke

    2015-01-01

    Researchers in Malaysia analysed the genomes of people with a rare genetic disorder to better understand people’s predisposition to cancer across generations.......Researchers in Malaysia analysed the genomes of people with a rare genetic disorder to better understand people’s predisposition to cancer across generations....

  15. Parrot "Understands" Zero

    Science.gov (United States)

    Journal of College Science Teaching, 2005

    2005-01-01

    The walnut sized brain of the African grey parrot may actually be capable of comprehending abstract mathematical concepts. The bird seems to understand a numerical concept akin to zero--an abstract notion that humans don't typically understand until they are three or four years old. Alex, the 28-year-old parrot who lives in a Brandeis University…

  16. Approaches to understand culture

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard; Rauner, Felix

    1996-01-01

    Different approaches to understand the concept ofculture are presented and evaluated. The author'sconcept of culture is defined. Different aspectsof the concept are discussed.......Different approaches to understand the concept ofculture are presented and evaluated. The author'sconcept of culture is defined. Different aspectsof the concept are discussed....

  17. Understanding cancer onset

    DEFF Research Database (Denmark)

    Veldhuis, Djuke

    2015-01-01

    Researchers in Malaysia analysed the genomes of people with a rare genetic disorder to better understand people’s predisposition to cancer across generations.......Researchers in Malaysia analysed the genomes of people with a rare genetic disorder to better understand people’s predisposition to cancer across generations....

  18. Understanding Generation X employees.

    Science.gov (United States)

    Kupperschmidt, B R

    1998-12-01

    Understanding Generation X employees--those born between 1961 and 1981--is essential if they are to be recruited into and retained in nursing and their potential maximized. The author discusses the times, characteristics, and work values and demands of Generation X. Armed with an enhanced understanding, nurse administrators are better prepared to maximize the potential of Generation X employees.

  19. Landform Geodiversity - State of the Art and future Suggestions

    Science.gov (United States)

    Zwoliński, Zbigniew

    2014-05-01

    The purpose of this paper is to present the current state of understanding of geodiversity in general terms and with regard to the relief forms of the earth. It will be pointed the key factors and elements for investigation of the landform geodiversity. A subject area of landform geodiversity encompasses among others the couple relationships between geology/lithology and landforms, the couple connections between landforms and water as well as the climate, the multi-directional connections/relationships/feedbacks between landforms and other/all components of the natural environment, the linkage between landform geodiversity and morphoclimatic zones, the role of anthropopression (anthropogenetic factors) within landform geodiversity, landform geodiversity in man-made environment, classification and typology of landform geodiversity, and the location and nature of past and present unique landforms. Geodiversity research is carried out in many countries and by different authors. Each research approaches represented by these authors differentiate a bit. An overview of these research approaches will be one part of this presentation. After the review of the methodological assumptions will be a brief overview of the research methods used by different authors. On the one hand the variety of research methods is justified because they correspond to the characteristics of the investigated areas and indicate the best way to describe the landform geodiversity. On the other hand the variety of research methods should also be seen as common, universal methodic solutions for investigation of geodiversity to comparative studies in the glocal scale, i.e. from local through regional to global scales. At the end of the presentation will be presented the selected future aspects of the landform geodiversity in the context, inter alia, the relationship to biodiversity, the role of the anthropopression in geodiversity, ecosystem services, sustainable development, and geoconservation.

  20. Current clinical approach to achalasia

    Institute of Scientific and Technical Information of China (English)

    Alexander J Eckardt; Volker F Eckardt

    2009-01-01

    Idiopathic achalasia is a rare primary motility disorder of the esophagus.The classical features are incomplete relaxation of a frequently hypertensive lower esophageal sphincter (LES) and a lack of peristalsis in the tubular esophagus.These motor abnormalities lead to dysphagia,stasis,regurgitation,weight loss,or secondary respiratory complications.Although major strides have been made in understanding the pathogenesis of this rare disorder,including a probable autoimmune mediated destruction of inhibitory neurons in response to an unknown insult in genetically susceptible individuals,a definite trigger has not been identified.The diagnosis of achalasia is suggested by clinical features and confirmed by further diagnostic tests,such as esophagogastroduodenoscopy (EGD),manometry or barium swallow.These studies are not only used to exclude pseudoachalasia,but also might help to categorize the disease by severity or clinical subtype.Recent advances in diagnostic methods,including high resolution manometry (HRM),might allow prediction of treatment responses.The primary treatments for achieving long-term symptom relief are surgery and endoscopic methods.Although limited high-quality data exist,it appears that laparoscopic Heller myotomy with partial fundoplication is superior to endoscopic methods in achieving long-term relief of symptoms in the majority of patients.However,the current clinical approach to achalasia will depend not only on patients' characteristics and clinical subtypes of the disease,but also on local expertise and patient preferences.