WorldWideScience

Sample records for current federal regulations

  1. Shared Solar. Current Landscape, Market Potential, and the Impact of Federal Securities Regulation

    Energy Technology Data Exchange (ETDEWEB)

    Feldman, David [National Renewable Energy Lab. (NREL), Golden, CO (United States); Brockway, Anna M. [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States); Ulrich, Elaine [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States); Margolis, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-04-01

    This report provides a high-level overview of the current U.S. shared solar landscape and the impact that a given shared solar program’s structure has on requiring federal securities oversight, as well as an estimate of market potential for U.S. shared solar deployment.

  2. Shared Solar. Current Landscape, Market Potential, and the Impact of Federal Securities Regulation

    Energy Technology Data Exchange (ETDEWEB)

    Feldman, David [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Brockway, Anna M. [U.S. Department of Energy, Washington, DC (United States); Ulrich, Elaine [U.S. Department of Energy, Washington, DC (United States); Margolis, Robert [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2015-04-07

    This report provides a high-level overview of the current U.S. shared solar landscape, the impact that a given shared solar program’s structure has on requiring federal securities oversight, as well as an estimate of market potential for U.S. shared solar deployment.

  3. Electronic Code of Federal Regulations

    Data.gov (United States)

    National Archives and Records Administration — The Electronic Code of Federal Regulations (e-CFR) is the codification of the general and permanent rules published in the Federal Register by the executive...

  4. Shared Solar: Current Landscape, Market Potential, and the Impact of Federal Securities Regulation; NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-05-27

    This presentation provides a high-level overview of the current U.S. shared solar landscape, the impact that a given shared solar program's structure has on requiring federal securities oversight, as well as an estimate of market potential for U.S. shared solar deployment.

  5. Deceptive Business Practices: Federal Regulations.

    Science.gov (United States)

    Rohrer, Daniel Morgan

    Federal regulations to prevent deceptive advertising seek to balance the advertiser's freedom of speech with protection of the consumer. This paper discusses what the Federal Trade Commission (FTC) has done to regulate advertising and evaluates the adequacy of its controls. The commission uses cease-and-desist orders, affirmative disclosure,…

  6. Federal Gasoline Regulations

    Science.gov (United States)

    The Clean Air Act requires EPA to regulate fuels and fuel additives for use in mobile sources if such fuel, fuel additive or any emission products causes or contributes to air or water pollution that may endanger the public health or welfare.

  7. Federalism in Pakistan, Current Developments

    Directory of Open Access Journals (Sweden)

    Razia Musarrat

    2012-04-01

    Full Text Available Purpose of this study is to elaborate the political issues and challenges faces by the federation of Pakistan during and after the Gen. Pervez Musharraf government. In this paper effort is made to discuss those issues on the biases of which politics of federalism started in the country. Pinching problems that caused disintegration to Pakistan are also discussed. Those issues are also discussed in details which are a constant threat to the “new federation of Pakistan”. Authors also focus on the 2008 elections and its consequences on Pakistan politics. All the results of this research are proved via review of the previous literature. Researchers have proved that as Pakistan has a diversified culture so federalism is best suited for its political structure. Researchers have also discussed few suggestive solutions for better bureaucracy.

  8. State-federal interactions in nuclear regulation

    Energy Technology Data Exchange (ETDEWEB)

    Pasternak, A.D.; Budnitz, R.J.

    1987-12-01

    The Atomic Energy Act of 1954 established, and later Congressional amendments have confirmed, that except in areas which have been explicitly granted to the states, the federal government possesses preemptive authority to regulate radiation hazards associated with the development and use of atomic energy. Since the passage of the original Act, numerous decisions by the courts have reaffirmed the legitimacy of federal preemption, and have defined and redefined its scope. In this study, the aim is to explore the underlying issues involved in federal preemption of radiation-hazard regulation, and to recommend actions that the Department of Energy and other agencies and groups should consider undertaking in the near term to protect the preemption principle. Appropriate roles of the states are discussed, as well as recent state-level activities and their rationale, and several current arenas in which state-federal conflicts about regulation of hazards are being played out. The emphasis here is on four particular arenas that are now important arenas of conflict, but the issues discussed are far broader in scope. These four arenas are: state-level moratorium activity; emergency planning for reactors; conflicts arising from state financial regulation; and inroads in federal preemption through litigation under state law.

  9. A Guide to Federal Reserve Regulations.

    Science.gov (United States)

    Federal Reserve Bank of New York, NY.

    The Board of Governors of the Federal Reserve System and the Federal Reserve Banks administer more than two dozen regulations affecting a wide variety of financial activities. The regulations concern the functions of the central bank and its relationships with financial institutions, the activities of commercial banks and bank holding companies,…

  10. Code of Federal Regulations Title 21

    Data.gov (United States)

    U.S. Department of Health & Human Services — This database contains the most recent revision from the Government Printing Office (GPO) of the Code of Federal Regulations (CFR) Title 21 - Food and Drugs.

  11. Code of Federal Regulations Title 21

    Data.gov (United States)

    U.S. Department of Health & Human Services — This database contains the most recent revision from the Government Printing Office (GPO) of the Code of Federal Regulations (CFR) Title 21 - Food and Drugs.

  12. Federal Securities Regulations and Stock Market Returns

    OpenAIRE

    Tung Liu; Gary Santoni; Courtenay Cliff Stone

    2008-01-01

    This paper examines the impact of federal securities statutes (seven major legislative acts and 535 amendments) on the mean and variance of total real U.S. stock market returns. In contrast to previous work, this study controls for the persistence of the variability of stock returns, employs a longer time period, utilizes a broader array of stocks and examines the impact of seven federal securities regulations and their selected amendments from 1933 through 2001. Despite the popular appeal of...

  13. 76 FR 68040 - Federal Acquisition Regulation; Labor Relations Costs

    Science.gov (United States)

    2011-11-02

    ... careful review of public comments, discussed below, DoD, GSA, and NASA have concluded that the proposed... Federal Acquisition Regulation; Labor Relations Costs AGENCY: Department of Defense (DoD), General....205-21, the cost principle addressing labor relations costs. Currently, this cost principle states...

  14. 77 FR 181 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-55; Introduction

    Science.gov (United States)

    2012-01-03

    ... Space Administration 48 CFR Chapter 1 Federal Acquisition Regulation; Final Rules #0;#0;Federal Register... Acquisition Regulation; Federal Acquisition Circular 2005-55; Introduction AGENCIES: Department of Defense (Do... Acquisition Regulation (FAR) rules agreed to by DoD, GSA, and NASA in this Federal Acquisition Circular...

  15. 76 FR 31393 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-52; Introduction

    Science.gov (United States)

    2011-05-31

    ... implement Executive Order 13514, Federal Leadership in Environmental, Energy, and Economic Performance, and... specified, all Federal Acquisition Regulation (FAR) ] and other directive material contained in FAC...

  16. 40 CFR 35.936-10 - Federal procurement regulations.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Federal procurement regulations. 35.936... FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.936-10 Federal procurement regulations. Regulations applicable to direct Federal procurement...

  17. 1 CFR 12.2 - Code of Federal Regulations.

    Science.gov (United States)

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Code of Federal Regulations. 12.2 Section 12.2... REGISTER PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.2 Code of Federal Regulations. (a) Copies of the Code of Federal Regulations in paper or microfiche form shall be made available...

  18. 41 CFR 101-1.102 - Federal Property Management Regulations.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Federal Property Management Regulations. 101-1.102 Section 101-1.102 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1-Regulation...

  19. 1 CFR 11.3 - Code of Federal Regulations.

    Science.gov (United States)

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Code of Federal Regulations. 11.3 Section 11.3... REGISTER PUBLICATIONS SUBSCRIPTIONS § 11.3 Code of Federal Regulations. (a) The subscription price for a complete set of the Code of Federal Regulations is $1,019 per year for the bound, paper edition, or...

  20. Target Benefit Plans: Improving Access for Federally Regulated Employees

    OpenAIRE

    Randy Bauslaugh

    2014-01-01

    Despite having been available for decades, target benefit pension plans (TBPs) will continue to be resisted by federally regulated employers unless a legal flaw is fixed, according to a report from the C.D. Howe Institute. In “Target Benefit Plans: Improving Access for Federally Regulated Employees,” author Randy Bauslaugh finds that TBPs are rarely adopted by federally regulated private-sector employers because federal pension law casts doubt over the ability of employers to limit their fina...

  1. 78 FR 26518 - Federal Acquisition Regulation; Government Property

    Science.gov (United States)

    2013-05-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Part 52 Federal Acquisition Regulation; Government Property CFR Correction In Title 48 of the Code of Federal Regulations...

  2. [Current ascariasis situation in the Russian Federation].

    Science.gov (United States)

    Darchenkova, N N; Romanenko, N A; Chernyshenko, A I

    2006-01-01

    In the Russian Federation (RF), ascariasis remains to be the most common geohelminthiasis, in children in particular. With its overall reduction, the prevalence of ascariasis is very uneven on the RF territory. In the past 15 years, from 1991 to 2004, there was a steady-state decrease in the incidence of ascariasis from 79.5 to 46.0 per 100,000. Its incidence rates remained higher than the average Russian ones in 33 RF subjects and lower than those in 48 subjects and began reducing in 8 subjects in the past 4 years. Of the 33 RF subjects wherein the incidence rates were constantly greater than the average Russian ones, 27 subjects are located in the natural background-favorable areas. In the past 15 years, there was an increase in the impact of socioeconomic factors on the higher incidence of ascariasis: the population's migration; the delivery and transport of Ascaris egg-contaminated greens, vegetables, berries; the development of hothouse gardening, and, as a result, the occurrence of ascariasis in the northern areas of the country, as well as the use of discharged waters for soil fertilization to grow crops. The territory of Russia was first epidemiologically districted in the context of ascariasis, by taking into account the natural background and socioeconomic factors. The area of ascariasis is on the rise. In all RF subjects, public health and social security bodies should constantly keep in mind the problem in ascariasis control and prevention.

  3. 76 FR 22899 - Discontinuance of the Looseleaf Version of the Federal Management Regulation (FMR) and Federal...

    Science.gov (United States)

    2011-04-25

    ... Travel Regulation (FTR) AGENCY: Office of Governmentwide Policy, General Services Administration (GSA... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES... Travel Regulation (FTR). DATES: This notice is effective April 25, 2011. FOR FURTHER INFORMATION...

  4. 21 CFR 100.2 - State enforcement of Federal regulations.

    Science.gov (United States)

    2010-04-01

    ... Federal regulations. (a) Under section 307 of the Federal Food, Drug, and Cosmetic Act (the act), a State...-605), Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch... notification pursuant to section 307(b)(1) of the Federal Food, Drug, and Cosmetic Act (21 U.S.C....

  5. 78 FR 80367 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-72; Introduction

    Science.gov (United States)

    2013-12-31

    ...This document summarizes the Federal Acquisition Regulation (FAR) rules agreed to by the Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council (Councils) in this Federal Acquisition Circular (FAC) 2005-72. A companion document, the Small Entity Compliance Guide (SECG), follows this FAC. The FAC, including the SECG, is available via the Internet at......

  6. 75 FR 51392 - Federal Management Regulation; Transportation Management

    Science.gov (United States)

    2010-08-20

    ... 1] RIN 3090-AJ03 Federal Management Regulation; Transportation Management AGENCY: Office of... Administration (GSA) is amending the Federal Management Regulation (FMR) by updating its coverage on transportation management. This final rule updates definitions and corrects mailing and Web site addresses....

  7. 76 FR 76622 - Federal Management Regulation; Motor Vehicle Management

    Science.gov (United States)

    2011-12-08

    ... Change 2011-03; FMR Case 2011-102-2; Docket 2011-0011; Sequence 2] RIN 3090-AJ14 Federal Management Regulation; Motor Vehicle Management AGENCY: Office of Governmentwide Policy, (GSA). ACTION: Final rule. SUMMARY: The General Services Administration is amending the Federal Management Regulation (FMR)...

  8. 76 FR 31545 - Federal Management Regulation; Motor Vehicle Management

    Science.gov (United States)

    2011-06-01

    ... ADMINISTRATION 41 CFR Part 102-34 RIN 3090-AJ14 Federal Management Regulation; Motor Vehicle Management AGENCY...: The General Services Administration is proposing to amend the Federal Management Regulation (FMR) by....C. 553(a)(2) because it applies to agency management. However, this proposed rule is being...

  9. 78 FR 80381 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-72; Small Entity Compliance Guide

    Science.gov (United States)

    2013-12-31

    ...This document is issued under the joint authority of DOD, GSA, and NASA. This Small Entity Compliance Guide has been prepared in accordance with section 212 of the Small Business Regulatory Enforcement Fairness Act of 1996. It consists of a summary of the rules appearing in Federal Acquisition Circular (FAC) 2005-72, which amends the Federal Acquisition Regulation (FAR). An asterisk (*) next......

  10. 32 CFR 516.29 - Federal statutes and regulations.

    Science.gov (United States)

    2010-07-01

    ... 516.29 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION Individual Liability § 516.29 Federal statutes and regulations. (a... individual. (b) Federal Employees Liability Reform and Tort Compensation Act of l988 (FELRTCA or the...

  11. 75 FR 40763 - Federal Management Regulation; Sale of Personal Property

    Science.gov (United States)

    2010-07-14

    ... ADMINISTRATION 41 CFR Part 102-38 RIN 3090-AJ04 Federal Management Regulation; Sale of Personal Property AGENCY... the provisions for the sale of personal property through Federal Asset Sales (FAS) Sales Centers..., Office of Governmentwide Policy, Personal Property Management Policy, at (202) 501-3828, or e-mail...

  12. 77 FR 67366 - Federal Acquisition Regulation; Information Collection; Travel Costs

    Science.gov (United States)

    2012-11-09

    ... Regulation; Information Collection; Travel Costs AGENCY: Department of Defense (DOD), General Services... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE... collection requirement concerning Travel Costs. Public comments are particularly invited on: Whether...

  13. William D. Ford Federal Direct Loan Program. Final Regulations. Federal Register, Department of Education, 34 CFR Part 685

    Science.gov (United States)

    National Archives and Records Administration, 2014

    2014-01-01

    The purpose of this regulatory action is to amend the regulations governing the William D. Ford Federal Direct Loan (Direct Loan) Program (§ 685.200 of title 34 of the Code of Federal Regulations (CFR)). These regulations strengthen and improve administration of the Federal Direct PLUS Loan Program authorized under title IV of the Higher Education…

  14. 78 FR 23885 - Federal Seed Act Program; Request for Extension and Revision of a Currently Approved Information...

    Science.gov (United States)

    2013-04-23

    ... Agricultural Marketing Service Federal Seed Act Program; Request for Extension and Revision of a Currently... collection 7 CFR part 201 for Federal Seed Act Labeling and Enforcement. DATES: Comments on this document... submitted online at www.regulations.gov or sent to Fawad S. Shah, Director, Seed Regulatory and...

  15. Federal Environmental Regulations Impacting Hydrocarbon Exploration, Drilling, and Production Operations

    Energy Technology Data Exchange (ETDEWEB)

    Carroll, Herbert B.; Johnson, William I.

    1999-04-27

    Waste handling and disposal from hydrocarbon exploration, drilling, and production are regulated by the US Environmental Protection Agency (EPA) through federal and state regulations and/or through implementation of federal regulations. Some wastes generated in these operations are exempt under the Resource Conservation and Recovery Act (RCRA) but are not exempt under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), Superfund Amendments and Reauthorization Act (SARA), and other federal environmental laws. Exempt wastes remain exempt only if they are not mixed with hazardous wastes or hazardous substances. Once mixture occurs, the waste must be disposed as a hazardous material in an approved hazardous waste disposal facility. Before the Clean Air Act as amended in 1990, air emissions from production, storage, steam generation, and compression facilities associated with hydrocarbon exploration, drilling, and production industry were not regulated. A critical proposed regulatory change which will significantly effect Class II injection wells for disposal of produced brine and injection for enhanced oil recovery is imminent. Federal regulations affecting hydrocarbon exploration, drilling and production, proposed EPA regulatory changes, and a recent significant US Court of Appeals decision are covered in this report. It appears that this industry will, in the future, fall under more stringent environmental regulations leading to increased costs for operators.

  16. 45 CFR Appendix I to Part 617 - List of Age Distinctions Provided in Federal Statutes or Regulations Affecting Federal Financial...

    Science.gov (United States)

    2010-10-01

    ... Statutes or Regulations Affecting Federal Financial Assistance Administered by NSF I Appendix I to Part 617.... 617, App. I Appendix I to Part 617—List of Age Distinctions Provided in Federal Statutes or Regulations Affecting Federal Financial Assistance Administered by NSF I. Section 6 of Pub. L. 94-86, 42...

  17. 77 FR 12930 - Federal Acquisition Regulation: Socioeconomic Program Parity

    Science.gov (United States)

    2012-03-02

    ... (SDVOSB) Program, or the Women-Owned Small Business (WOSB) Program. DATES: Effective Date: April 2, 2012...-Disabled Veteran-Owned Small Business (SDVOSB) Program (see subpart 19.14); or (iv) Women-Owned Small... amending the Federal Acquisition Regulation (FAR) to implement a section of the Small Business Jobs Act...

  18. 78 FR 37690 - Federal Acquisition Regulation; Price Analysis Techniques

    Science.gov (United States)

    2013-06-21

    ... Federal Acquisition Regulation; Price Analysis Techniques AGENCY: Department of Defense (DoD), General... clarify and give a precise reference in the use of a price analysis technique in order to establish a fair... reference used in FAR 15.404-1(b)(2)(i). FAR 15.404-1(b)(2) addresses various price analysis techniques and...

  19. 77 FR 40552 - Federal Acquisition Regulation; Price Analysis Techniques

    Science.gov (United States)

    2012-07-10

    ... Federal Acquisition Regulation; Price Analysis Techniques AGENCY: Department of Defense (DoD), General... clarify the use of a price analysis technique in order to establish a fair and reasonable price. DATES....404-1(b)(2) addresses various price analysis techniques and procedures the Government may use to...

  20. 77 FR 189 - Federal Acquisition Regulation; Brand-Name Specifications

    Science.gov (United States)

    2012-01-03

    ...-AK55 Federal Acquisition Regulation; Brand-Name Specifications AGENCIES: Department of Defense (DoD... brand-name specifications. DATES: Effective Date: February 2, 2012. FOR FURTHER INFORMATION CONTACT: Mr... of Management and Budget (OMB) memoranda and policies on the use of brand- name specifications....

  1. Got junk? The federal role in regulating "competitive" foods.

    Science.gov (United States)

    Salinsky, Eileen

    2009-12-11

    A wide variety of food and beverage items are available in schools in addition to the school meals provided through the National School Lunch Program and School Breakfast Program. A long-standing source of controversy, the need for stronger federal restrictions on foods that compete with school meals is again under debate. This issue brief examines the availability and consumption of competitive foods, explores the regulation of these foods at the federal level, considers trends in state and local restrictions, and summarizes perceived barriers to improving the nutritional quality of competitive food options.

  2. 78 FR 29245 - U.S. General Services Administration Federal Property Management Regulations; Administrative Wage...

    Science.gov (United States)

    2013-05-20

    ... Administration Federal Property Management Regulations; Administrative Wage Garnishment AGENCY: Office of the... amending the U.S. General Services Administration Property Management Regulation (GSPMR) to remove... telephone number. The Administrative Wage Garnishment Code of Federal Regulations (CFR) Parts affected...

  3. Issues in federal preemption of state appliance energy efficiency regulations

    Energy Technology Data Exchange (ETDEWEB)

    Fang, J.M.; Balistocky, S.; Schaefler, A.M.

    1982-12-01

    The findings and conclusions of the analysis of the various issues involved in the federal preemption of state regulations for the DOE no standard rule on covered appliances are summarized. The covered products are: refrigerators, refrigerator-freezers, freezers, clothes dryers, kitchen ranges and ovens, water heaters (excluding heat pump water heaters), room air conditioners, central air conditioners (excluding heat pumps), and furnaces. A detailed discussion of the rationale for the positions of groups offering comment for the record is presneted. The pertinent categories of state and local regulations and programs are explained, then detailed analysis is conducted on the covered products and regulations. Issues relating to the timing of preemption of state regulations are discussed, as well as issues relating to burden of proof, contents of petitions for exemptions from preemption, criteria for evaluating petitions, and procedural and other issues. (LEW)

  4. 75 FR 22805 - Federal Travel Regulation; Relocation Allowances; Standard Data Dictionary for Collection of...

    Science.gov (United States)

    2010-04-30

    ... online a proposed FTR bulletin that contains the data dictionary that large Federal agencies must use in... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION Federal Travel Regulation; Relocation Allowances; Standard Data Dictionary for Collection...

  5. Federal Trade Commission's authority to regulate marketing to children: deceptive vs. unfair rulemaking.

    Science.gov (United States)

    Pomeranz, Jennifer L

    2011-01-01

    Food and beverage marketing directed at children is of increasing concern to the public health and legal communities. The new administration at the Federal Trade Commission and abundant science on the topic make it a particularly opportune time for the government to reconsider regulating marketing directed at youth. This Article analyzes the Commission's authority to regulate food and beverage marketing directed at children under its jurisdiction over unfair and deceptive acts and practices to determine which avenue is most viable. The author finds that the Federal Trade Commission has the authority to regulate deceptive marketing practices directed at vulnerable populations. Although the Commission can issue individual orders, its remedial power to initiate rules would better address the pervasiveness of modern marketing practices. The Commission does not currently have the power to regulate unfair marketing to children; however, even if Congress reinstated this authority, the Commission's authority over deceptive marketing may be preferable to regulate these practices. Deceptive communications are not protected by the First Amendment and the deceptive standard matches the science associated with marketing to children. The Federal Trade Commission has the authority to initiate rulemaking in the realm of food and beverage marketing to children as deceptive communications in interstate commerce, in violation of the Federal Trade Commission Act. However, to effectuate this process, Congress would need to grant the Commission the authority to do so under the Administrative Procedures Act.

  6. 76 FR 38000 - Removal of Certain Sanctions Regulations Relating to the Former Federal Republic of Yugoslavia

    Science.gov (United States)

    2011-06-29

    ... Relating to the Former Federal Republic of Yugoslavia AGENCY: Office of Foreign Assets Control, Treasury...'') is removing from the Code of Federal Regulations the Federal Republic of Yugoslavia (Serbia and..., the Federal Republic of Yugoslavia (Serbia and Montenegro) Kosovo Sanctions Regulations, and...

  7. 76 FR 8989 - Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting References

    Science.gov (United States)

    2011-02-16

    ... 9000-AM00 Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting... to amend the Federal Acquisition Regulation (FAR) to update references to authoritative accounting standards owing to the Financial Accounting Standards Board's (FASB's) Accounting Standards...

  8. 41 CFR 101-1.101 - Federal Property Management Regulations System.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Federal Property Management Regulations System. 101-1.101 Section 101-1.101 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1...

  9. 76 FR 50461 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Types of...

    Science.gov (United States)

    2011-08-15

    ... Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Types of Contracts AGENCY: Defense Acquisition Regulations System, Department of... information collection requirement. SUMMARY: In compliance with Section 3506(c)(2)(A) of the...

  10. 78 FR 41331 - Federal Acquisition Regulation; Publicizing Contract Actions; Contracting by Negotiation

    Science.gov (United States)

    2013-07-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Parts 5 and 15 Federal Acquisition Regulation; Publicizing Contract Actions; Contracting by Negotiation CFR Correction...

  11. 76 FR 48863 - Federal Travel Regulation (FTR); Relocation Allowances-Standard Mileage Rate for Moving Purposes

    Science.gov (United States)

    2011-08-09

    ... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION Federal Travel Regulation (FTR); Relocation Allowances--Standard Mileage Rate for Moving Purposes AGENCY: Office of Governmentwide Policy, General Services Administration (GSA). ACTION: Notice of...

  12. 75 FR 36414 - Federal Travel Regulation (FTR); Directions for Reporting Other Than Coach-Class Accommodations...

    Science.gov (United States)

    2010-06-25

    ... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION Federal Travel Regulation (FTR); Directions for Reporting Other Than Coach-Class Accommodations for Employees on Official Travel AGENCY: Office of Governmentwide Policy, General...

  13. Current perspectives on shoot branching regulation

    Directory of Open Access Journals (Sweden)

    Cunquan YUAN,Lin XI,Yaping KOU,Yu ZHAO,Liangjun ZHAO

    2015-03-01

    Full Text Available Shoot branching is regulated by the complex interactions among hormones, development, and environmental factors. Recent studies into the regulatory mecha-nisms of shoot branching have focused on strigolactones, which is a new area of investigation in shoot branching regulation. Elucidation of the function of the D53 gene has allowed exploration of detailed mechanisms of action of strigolactones in regulating shoot branching. In addition, the recent discovery that sucrose is key for axillary bud release has challenged the established auxin theory, in which auxin is the principal agent in the control of apical dominance. These developments increase our understan-ding of branching control and indicate that regulation of shoot branching involves a complex network. Here, we first summarize advances in the systematic regulatory network of plant shoot branching based on current information. Then we describe recent developments in the synthesis and signal transduction of strigolactones. Based on these considerations, we further summarize the plant shoot branching regulatory network, including long distance systemic signals and local gene activity mediated by strigolactones following perception of external envi-ronmental signals, such as shading, in order to provide a comprehensive overview of plant shoot branching.

  14. 75 FR 37300 - Correction of Code of Federal Regulations: Removal of Temporary Listing of Benzylfentanyl and...

    Science.gov (United States)

    2010-06-29

    ... substances and all references to these compounds are being deleted from DEA regulations. DATES: This... correction by removing benzylfentanyl and thenylfentanyl from the Code of Federal Regulations, DEA finds it... Enforcement Administration 21 CFR Part 1308 RIN 1117-AB26 Correction of Code of Federal Regulations: Removal...

  15. 77 FR 14480 - Defense Federal Acquisition Regulation Supplement: Commercial Determination Approval (DFARS Case...

    Science.gov (United States)

    2012-03-12

    ... acquisitions made pursuant to Federal Acquisition Regulation (FAR) 12.102(f)(1).'' This language clarifies that... Defense Acquisition Regulations System 48 CFR Part 212 RIN 0750-AH61 Defense Federal Acquisition Regulation Supplement: Commercial Determination Approval (DFARS Case 2011-D041) AGENCY: Defense Acquisition...

  16. 75 FR 60263 - Federal Acquisition Regulation; Offering a Construction Requirement-8(a) Program

    Science.gov (United States)

    2010-09-29

    ... Federal Acquisition Regulation; Offering a Construction Requirement--8(a) Program AGENCIES: Department of... Regulations Council (Councils) are issuing a final rule amending the Federal Acquisition Regulation (FAR) to revise FAR subpart 19.8, Contracting with the Small Business Administration (The 8(a) Program),...

  17. 76 FR 18652 - Revision to the Manual of Regulations and Procedures for Federal Radio Frequency Management

    Science.gov (United States)

    2011-04-05

    ... Manual of Regulations and Procedures for Federal Radio Frequency Management AGENCY: National... regulations, which relate to the public availability of the Manual of Regulations and Procedures for Federal Radio Frequency Management (NTIA Manual). Specifically, NTIA updates the version of the Manual...

  18. 78 FR 52097 - Revision to the Manual of Regulations and Procedures for Federal Radio Frequency Management

    Science.gov (United States)

    2013-08-22

    ... Manual of Regulations and Procedures for Federal Radio Frequency Management AGENCY: National... regulations, which relate to the public availability of the Manual of Regulations and Procedures for Federal Radio Frequency Management (NTIA Manual). Specifically, NTIA is releasing a new edition of the...

  19. 75 FR 54790 - Revision to the Manual of Regulations and Procedures for Federal Radio Frequency Management

    Science.gov (United States)

    2010-09-09

    ... Manual of Regulations and Procedures for Federal Radio Frequency Management AGENCY: National... regulations, which relate to the public availability of the Manual of Regulations and Procedures for Federal Radio Frequency Management (NTIA Manual). Specifically, NTIA updates the version of the Manual...

  20. 75 FR 6818 - Revision to the Manual of Regulations and Procedures for Federal Radio Frequency Management

    Science.gov (United States)

    2010-02-11

    ... Manual of Regulations and Procedures for Federal Radio Frequency Management AGENCY: National... regulations, which relate to the public availability of the Manual of Regulations and Procedures for Federal Radio Frequency Management (NTIA Manual). Specifically, the NTIA updates the version of the Manual...

  1. 77 FR 75567 - Revision to the Manual of Regulations and Procedures for Federal Radio Frequency Management

    Science.gov (United States)

    2012-12-21

    ... Manual of Regulations and Procedures for Federal Radio Frequency Management AGENCY: National... regulations, which relate to the public availability of the Manual of Regulations and Procedures for Federal Radio Frequency Management (NTIA Manual). Specifically, NTIA updates the version of the Manual...

  2. 76 FR 56984 - Revision to the Manual of Regulations and Procedures for Federal Radio Frequency Management

    Science.gov (United States)

    2011-09-15

    ... Manual of Regulations and Procedures for Federal Radio Frequency Management AGENCY: National... regulations, which relate to the public availability of the Manual of Regulations and Procedures for Federal Radio Frequency Management (NTIA Manual). Specifically, NTIA updates the version of the Manual...

  3. 75 FR 71647 - Defense Federal Acquisition Regulation Supplement; Discussions Prior to Contract Award (DFARS...

    Science.gov (United States)

    2010-11-24

    ... Defense Acquisition Regulations System 48 CFR Part 215 Defense Federal Acquisition Regulation Supplement... amend the Defense Federal Acquisition Regulation Supplement (DFARS) to strongly encourage discussions... requirements. DoD notes the potential disadvantages of this proposed change in increased time to complete...

  4. 75 FR 76692 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2010-12-09

    ... Federal Acquisition Regulation Supplement; Business Systems--Definition and Administration (DFARS Case... INFORMATION: I. Background DoD published a proposed rule for Business Systems--Definition and...

  5. An examination of the Total Quality Management (TQM) concept given current Federal/DoD competition initiatives

    Science.gov (United States)

    Stabile, Michael E.

    1992-06-01

    Quality is vital to our defense and quality improvement is key to increasing productivity. The Department of Defense (DoD) Total Quality Management (TQM) effort has been given top priority by the Secretary of Defense. Many questions exist concerning the problems encountered when implementing TQM throughout DoD. This thesis looks at the compatibility of the TQM philosophy with current Federal Acquisition Regulation competition requirements. The writer concludes that the TQM philosophy implementation is compatible with existing competition policy.

  6. 78 FR 48123 - Federal Acquisition Regulation; Contractor Comment Period, Past Performance Evaluations

    Science.gov (United States)

    2013-08-07

    ... Federal Acquisition Regulation; Contractor Comment Period, Past Performance Evaluations AGENCY: Department... comments on past performance evaluations and making past performance evaluations available to source... Decisions'', require revisions to the acquisition regulations on past performance evaluations so...

  7. 78 FR 12755 - Federal Acquisition Regulation; Submission for OMB Review; Schedules for Construction Contracts

    Science.gov (United States)

    2013-02-25

    ... Regulation; Submission for OMB Review; Schedules for Construction Contracts AGENCY: Department of Defense... collection requirement concerning schedules for construction contracts. A notice was published in the Federal..., Schedules for Construction Contracts by any of the following methods: Regulations.gov :...

  8. 75 FR 13422 - Federal Acquisition Regulation; FAR Case 2008-015, Payments Under Fixed-Price Architect-Engineer...

    Science.gov (United States)

    2010-03-19

    ... Federal Acquisition Regulation; FAR Case 2008-015, Payments Under Fixed-Price Architect-Engineer Contracts... Architect-Engineer Contracts, currently requires contracting officers to withhold 10 percent of the amounts... payment withheld to apply under fixed-price architect-engineer (A-E) contracts (based on an assessment...

  9. 77 FR 13952 - Federal Acquisition Regulation; United States-Korea Free Trade Agreement

    Science.gov (United States)

    2012-03-07

    ... RIN 9000-AM18 Federal Acquisition Regulation; United States-Korea Free Trade Agreement AGENCY... Federal Acquisition Regulation (FAR) to implement the United States- Korea Free Trade Agreement. The...-Korea Free Trade Agreement (see the United States-Korea Free Trade Agreement Implementation Act (Pub. L...

  10. 76 FR 14562 - Federal Acquisition Regulation; Additional Requirements for Market Research

    Science.gov (United States)

    2011-03-16

    ... 52 RIN 9000-AL50 Federal Acquisition Regulation; Additional Requirements for Market Research AGENCY... interim rule amending the Federal Acquisition Regulation (FAR) to implement section 826, Market Research... items engages in market research as necessary before making purchases. DATES: Effective Date: April...

  11. 76 FR 68015 - Federal Acquisition Regulation; Notification of Employee Rights Under the National Labor...

    Science.gov (United States)

    2011-11-02

    ... activities related to the performance of the contract.'' The respondent stated that the following language at... 52 RIN 9000-AL76 Federal Acquisition Regulation; Notification of Employee Rights Under the National... adopted as final, without change, an interim rule amending the Federal Acquisition Regulation (FAR) to...

  12. 76 FR 72327 - NASA Federal Acquisition Regulation Supplement; Responsibility, Suspension and Debarment

    Science.gov (United States)

    2011-11-23

    ... [Federal Register Volume 76, Number 226 (Wednesday, November 23, 2011)] [Rules and Regulations] [Pages 72327-72328] [FR Doc No: 2011-30148] NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Part 1809 RIN 2700-AD54 NASA Federal Acquisition Regulation Supplement; Responsibility, Suspension and...

  13. 76 FR 31424 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-52; Small Entity Compliance Guide

    Science.gov (United States)

    2011-05-31

    ... GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Chapter 1 Federal... of Defense (DoD), General Services Administration (GSA), and National Aeronautics and Space..., operation and maintenance, management, and deconstruction practices in applicable acquisitions....

  14. 40 CFR 49.10050 - Federally-promulgated regulations and Federal implementation plans.

    Science.gov (United States)

    2010-07-01

    ...-Region X Implementation Plan for the Cow Creek Band of Umpqua Indians of Oregon § 49.10050 Federally... part of the implementation plan for the Reservation of the Cow Creek Band of Umpqua Indians: (a...

  15. 77 FR 56741 - Federal Acquisition Regulation; NAICS and Size Standards

    Science.gov (United States)

    2012-09-13

    ... contracting until the Small Business Administration (SBA) publishes corresponding industry size standards... published by the Small Business Administration and are available at http://www.sba.gov/content/table-small... Federal contracting until the Small Business Administration publishes corresponding industry...

  16. FGD uses in agriculture: status of federal regulations and support

    Science.gov (United States)

    In 2010 the EPA proposed regulations under RCRA to address the disposal of CCRs. Initially, the EPA proposed two regulatory options: 1) continue to regulate under Subtitle D, or 2) regulate under the more restrictive Subtitle C. After extensive study during the rulemaking process, EPA established r...

  17. 76 FR 4188 - Federal Acquisition Regulation; Public Access to the Federal Awardee Performance and Integrity...

    Science.gov (United States)

    2011-01-24

    ... business ethics and quality of prospective contractors competing for Federal contracts. That rulemaking... personal and/or business confidential information provided. FOR FURTHER INFORMATION CONTACT: Mr. Edward... business integrity, but lacks the functionality to make information immediately available to the public as...

  18. 76 FR 18324 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-51; Small Entity Compliance Guide

    Science.gov (United States)

    2011-04-01

    ...: Item I--Women-Owned Small Business (WOSB) Program (FAR Case 2010-015) (Interim) This interim rule amends the FAR to add subpart 19.15, Women-Owned Small Business Program, which will assist Federal agencies in achieving the 5 percent statutory goal for contracting with women-owned small business...

  19. 75 FR 77745 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-47; Small Entity Compliance Guide

    Science.gov (United States)

    2010-12-13

    ... specified below: Item I--Notification of Employee Rights Under the National Labor Relations Act (FAR Case... Executive Order 13496, Notification of Employee Rights Under Federal Labor Laws, as implemented by the... includes employee rights under the National Labor Relations Act, 29 U.S.C. 151 et seq. This Act...

  20. 76 FR 68013 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-54; Introduction

    Science.gov (United States)

    2011-11-02

    .... Employee Rights Under the National Labor Relations Act. II Preventing Personal 2008-025 Robinson. Conflicts... Employee Rights Under the National Labor Relations Act (FAR Case 2010-006) This rule adopts as final..., 2010, implementing Executive Order (E.O.) 13496, Notification of Employee Rights Under Federal...

  1. 75 FR 77721 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-47; Introduction

    Science.gov (United States)

    2010-12-13

    ... Notification of Employee 2010-006 McFadden. Rights Under the National Labor Relations Act (Interim). II HUBZone... as specified below: Item I--Notification of Employee Rights Under the National Labor Relations Act... implement Executive Order 13496, Notification of Employee Rights Under Federal Labor Laws, as implemented...

  2. 76 FR 7522 - Federal Acquisition Regulation; Enhancing Contract Transparency

    Science.gov (United States)

    2011-02-10

    ... telecommunications contracts; Links to GSA Advantage! Online Shopping for eBusiness and eBuy, GSA's electronic... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE....'' The respondents do not acknowledge any direct correlation between posting contracts online and...

  3. 36 CFR 241.3 - Federal refuge regulations.

    Science.gov (United States)

    2010-07-01

    ... birds, or fish, upon any National Forest lands or waters embraced within the boundaries of a military... utilization of game and non-game animals, game and non-game birds, and fish, upon national forest lands of the... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Federal refuge...

  4. 76 FR 23236 - Federal Acquisition Regulation; Organizational Conflicts of Interest

    Science.gov (United States)

    2011-04-26

    ... Office of Federal Procurement Policy (OFPP), in consultation with the Office of Government Ethics (OGE... then explained in more detail in FAR 3.1204. c. Marketing consultant. In addition, the existing definition of ``marketing consultant'' in FAR subpart 9.5 is removed as unnecessary because the...

  5. 76 FR 68037 - Federal Acquisition Regulation; Sudan Waiver Process

    Science.gov (United States)

    2011-11-02

    ... Operations in Sudan and Imports from Burma, in the Federal Register at 74 FR 40463 on August 11, 2009... that conducts restricted business operations in Sudan. In addition, the waiver request must address any... prohibition on contracting with entities that conduct restricted business operations in Sudan. This rule...

  6. 76 FR 31402 - Federal Acquisition Regulation; Contract Closeout

    Science.gov (United States)

    2011-05-31

    ... subparagraph (G) of this section. (I) List of all internal audit reports issued since the last disclosure of internal audit reports to the Government. (J) Annual internal audit plan of scheduled audits to be..., and NASA published a proposed rule in the Federal Register at 74 FR 42044 on August 20, 2009....

  7. Legal issues of the environmental safety regulation in the sphere of nanotechnology in Russian Federation

    Science.gov (United States)

    Belokrylova, Ekaterina A.

    2013-04-01

    development and application of nanoproducts, inspite of fact, that these relationships have a significant financial segment. Thus, according to the Federal Act from December 13, 2010 "About federal budget for 2011 year and the period of 2012 and 2013 years" the expenses for realisation of program "The infrastructure development of nano industry in Russian Federation for 2008-2011" were 250 milliard of Russian rubbles. The profound analyses of the current legal systems has demonstrated that nowadays the main legal regulation in nano sphere consist of some range of frame documents (accentuated by the author). Thereby, one of the most dynamic and developed field of innovative activities in Russian Federation - nanotechnology - is left out of environmental and legal area of protection and that is might lead to the raising level of ecological risks at the stage of creation and application nano products to the environment and humans' health. During the analyses of annual norms of the Report OECD "Nano technologies: the Environment, health and safety" the conclusion is following - 2010 Russia has an extremely low degree of conceptual realization of the program in the sphere of forming the policy connected with nanotechnology and its impact on the environment and also a lack of implementations of norms into the national legal systems in terms of the assessment criteria of nano safety EHS (Environmental, Health and Safety) and ELSI (Ethical, Legal and Social Issues). To the great regret, there is no independent and precise legal act about the ways to creat and apply nano products with the certain definitions and principles and, more importantly, with the level of legal obligations and responsibility. This gap is not possible to fill by just altering and editing the existed legal acts due to the lack of the state Russian regulation. Thus, one of the most dynamic fields of innovative activities - nano technologies - is practically out of the regulation. It might lead to an increase of

  8. 76 FR 27274 - Defense Federal Acquisition Regulation Supplement; Rules of the Armed Services Board of Contract...

    Science.gov (United States)

    2011-05-11

    ... Defense Acquisition Regulations System 48 CFR Chapter 2 Defense Federal Acquisition Regulation Supplement; Rules of the Armed Services Board of Contract Appeals AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is issuing a final rule to update the Rules...

  9. New Federal Regulations for Dredged and Fill Material

    Science.gov (United States)

    Smith, David D.

    1976-01-01

    Aided by Environmental Protection Agency (EPA) guidelines, the United States Army Corps of Engineers regulates the discharge of dredged and fill material, through a permit program, to all waters of the United States. This feature summarizes the key points of the Corps regulations and the EPA guidelines. (BT)

  10. 77 FR 11355 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2012-02-24

    ... Defense Federal Acquisition Regulation Supplement; Business Systems--Definition and Administration (DFARS... proposed rule for Business Systems-- Definition and Administration (DFARS Case 2009-D038) in the Federal... contractor business systems, DoD has clarified the definition and administration of contractor...

  11. 76 FR 46206 - NASA Implementation of Federal Acquisition Regulation (FAR) Award Fee Language Revision

    Science.gov (United States)

    2011-08-02

    ... SPACE ADMINISTRATION 48 CFR Part 1816 RIN 2700-AD69 NASA Implementation of Federal Acquisition Regulation (FAR) Award Fee Language Revision AGENCY: National Aeronautics and Space Administration. ACTION... Supplement (NFS) to implement the FAR Award Fee revision issued in Federal Acquisition Circular (FAC) 2005-46...

  12. 49 CFR 220.43 - Radio communications consistent with federal regulations and railroad operating rules.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Radio communications consistent with federal... Radio and Wireless Communication Procedures § 220.43 Radio communications consistent with federal regulations and railroad operating rules. Radio communication shall not be used in connection with a...

  13. 78 FR 6189 - Federal Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor Excise...

    Science.gov (United States)

    2013-01-29

    ... 9000-AM13 Federal Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor... excise tax on certain Federal procurement payments to foreign persons. The rule disallows the cost associated with the 2 percent excise tax on certain foreign procurements. DATES: Effective Date: February 28...

  14. 77 FR 202 - Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting References

    Science.gov (United States)

    2012-01-03

    ... 9000-AM00 Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting... accounting standards owing to the Financial Accounting Standards Board's Accounting Standards Codification of Generally Accepted Accounting Principles. DATES: Effective Date: February 2, 2012. FOR FURTHER...

  15. 76 FR 30362 - Federal Acquisition Regulation; Submission for OMB Review; Acquisition of Helium

    Science.gov (United States)

    2011-05-25

    ... ADMINISTRATION [OMB Control No. 9000-0113; Docket 2011-0079; Sequence 5] Federal Acquisition Regulation; Submission for OMB Review; Acquisition of Helium AGENCY: Department of Defense (DOD), General Services... approved information collection requirement concerning acquisition of helium. Public comments...

  16. Search 40 Code of Federal Regulations (CFR): Protection of the Environment

    Data.gov (United States)

    U.S. Environmental Protection Agency — Title 40 is the section of the Code of Federal Regulations (CFR) that deals with EPA's mission of protecting human health and the environment. This web page provides...

  17. Report: Wells Band Council Needs to Improve Its Accounting System to Comply With Federal Regulations

    Science.gov (United States)

    Report #14-2-0316, July 14, 2014. The Wells Band Council’s accounting system did not comply with federal regulations, which resulted in $390,000 of questioned costs and proposed high-risk designation for the grantee.

  18. 31 CFR 103.120 - Anti-money laundering program requirements for financial institutions regulated by a Federal...

    Science.gov (United States)

    2010-07-01

    ... requirements for financial institutions regulated by a Federal functional regulator or a self-regulatory... financial institutions regulated by a Federal functional regulator or a self-regulatory organization, and... futures commission merchants. A financial institution regulated by a self-regulatory organization shall...

  19. 78 FR 30304 - Federal Acquisition Regulation; Information Collection; Patents

    Science.gov (United States)

    2013-05-22

    ... Regulation; Information Collection; Patents AGENCY: Department of Defense (DOD), General Services... requirement concerning patents. DATES: Submit comments on or before July 22, 2013. ADDRESSES: Submit comments identified by Information Collection 9000- 0096, Patents, by any of the following methods:...

  20. 75 FR 17410 - Federal Acquisition Regulation; Information Collection; Government Property

    Science.gov (United States)

    2010-04-06

    ... Regulation; Information Collection; Government Property AGENCY: Department of Defense (DOD), General Services... approved information collection requirement concerning Government Property. Public comments are.... Purpose Property, as used in Part 45, means all property, both real and personal. It includes...

  1. 29 CFR 1471.135 - May the Federal Mediation and Conciliation Service exclude a person who is not currently...

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false May the Federal Mediation and Conciliation Service exclude....135 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1471.135 May the Federal Mediation...

  2. Energy-conserving development regulations: current practice

    Energy Technology Data Exchange (ETDEWEB)

    1980-05-01

    Almost every aspect of land development has an effect on energy use, from minute architectural details to broad considerations of urban density. Energy-efficiency depends in part on how development is planned and carried out. Conventional development regulations, such as zoning ordinances and subdivision regulations, can be adapted in many ways to promote energy conservation at the community level. This report is about energy-efficient site and neighborhood design. It examines recent experiences of local governments that have adopted new development regulations or amended existing ones to promote energy conservation, more efficient generation and distribution, or a switch to alternative, renewable sources. Although much has been written in recent years about saving energy through community design, actual experience in applying these new ideas is still limited. To date, most communities have focused their efforts on studying the problem, documenting consumption patterns, and writing reports and plans. Only a handful have amended their land-use controls for the express purpose of saving energy. This study identifies 13 of these pioneering communities, after undertaking a survey of over 1400 local, regional, and state planning agencies. It takes a look at their experiences, to learn what has been done, how well it has worked, and what problems have been encountered.

  3. The Rise of International Relations Programs in the Brazilian Federal Universities: Curriculum Specificities and Current Challenges

    Science.gov (United States)

    Ferreira, Marcos Alan S. V.

    2016-01-01

    The aim of this reflection is to study the new international relations (IR) programs introduced by Brazilian federal universities, looking comparatively at their curriculum specificities and current challenges. In recent years, Brazil has seen an increase of IR programs launched in several regions. Since 2003, the Ministry of Education is in the…

  4. 77 FR 54864 - Federal Acquisition Regulation; Documenting Contractor Performance

    Science.gov (United States)

    2012-09-06

    ... solicitation provisions and clauses referenced in 9.104-7); (6) Integrity and business ethics; and (7) Business... posted without change to http://www.regulations.gov , including any personal and/or business confidential...--Evaluation Ratings Definitions (for the Small Business Subcontracting Evaluation factor when the clause at 52...

  5. 77 FR 51784 - Federal Acquisition Regulation; Information Collection; Qualification Requirements

    Science.gov (United States)

    2012-08-27

    .... Under the qualification requirements, an end item, or a component thereof, may be required to be... Regulation; Information Collection; Qualification Requirements AGENCY: Department of Defense (DOD), General...: Under the provisions of the Paperwork Reduction Act, the Regulatory Secretariat will be submitting...

  6. 77 FR 10529 - Federal Acquisition Regulation; Information Collection; Delivery Schedules

    Science.gov (United States)

    2012-02-22

    ..., Time of Delivery, or FAR 52.211-9, Desired and Required Time of Delivery. The information is needed to... Regulation; Information Collection; Delivery Schedules AGENCY: Department of Defense (DOD), General Services... requirement concerning delivery schedules. Public comments are particularly invited on: Whether this...

  7. 78 FR 26573 - Federal Acquisition Regulation; Irrevocable Letters of Credit

    Science.gov (United States)

    2013-05-07

    ... http://www.regulations.gov , including any personal and/or business confidential information provided... equity). E.O. 13563 emphasizes the importance of quantifying both costs and benefits, of reducing costs..., therefore, was not subject to review under section 6(b) of Executive Order 12866, Regulatory Planning...

  8. 77 FR 63805 - Federal Acquisition Regulation; Information Collection; Service Contracting

    Science.gov (United States)

    2012-10-17

    ... Regulation; Information Collection; Service Contracting AGENCY: Department of Defense (DOD), General Services.... Select the link ``Submit a Comment'' that corresponds with ``Information Collection 9000-0152, Service..., company name (if any), and ``Information Collection 9000-0152, Service Contracting'' on your...

  9. 78 FR 59317 - Federal Acquisition Regulation; Ending Trafficking in Persons

    Science.gov (United States)

    2013-09-26

    ...) Harmonize the requirements of 52.203-13, Contractor Code of Business Ethics and Conduct with the... posted without change to http://www.regulations.gov , including any personal and/or business confidential... performance, at the workplace and on the contractor's Web site (if one is maintained). Contractors would be...

  10. 78 FR 31551 - Federal Acquisition Regulation; Submission for OMB Review; Commerce Patent Regulations

    Science.gov (United States)

    2013-05-24

    ... Regulation; Submission for OMB Review; Commerce Patent Regulations AGENCIES: Department of Defense (DOD... approved information collection requirement concerning Department of Commerce patent regulations. A notice... Collection 9000- 0095, Commerce Patent Regulations, by any of the following methods: Regulations.gov :...

  11. 77 FR 27548 - Federal Acquisition Regulation; Free Trade Agreement-Colombia

    Science.gov (United States)

    2012-05-10

    ... 9000-AM24 Federal Acquisition Regulation; Free Trade Agreement--Colombia AGENCY: Department of Defense... Acquisition Regulation (FAR) to implement the United States- Colombia Trade Promotion Agreement. This Trade... eligible products and services from Colombia. DATES: Effective Date: May 15, 2012. Comment Date:...

  12. 76 FR 18304 - Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program

    Science.gov (United States)

    2011-04-01

    ... implement the Small Business Administration's regulations establishing the Women-Owned Small Business... Business Administration (SBA) regulations at 13 CFR part 127, entitled ``Women-Owned Small Business Federal... business concerns, including women-owned small business (WOSB) concerns and economically......

  13. 77 FR 30359 - Defense Federal Acquisition Regulation Supplement: New Free Trade Agreement With Colombia (DFARS...

    Science.gov (United States)

    2012-05-22

    ... Regulation Supplement: New Free Trade Agreement With Colombia (DFARS Case 2012-D032) AGENCY: Defense... United States--Colombia Trade Promotion ] Agreement. This Trade Promotion Agreement is a free trade... Federal Acquisition Regulation (FAR) as the Colombia Free Trade Agreement (FTA). The FTA provides for...

  14. 75 FR 34282 - Federal Acquisition Regulation; FAR Case 2009-013, Nonavailable Articles

    Science.gov (United States)

    2010-06-16

    ... Regulation; FAR Case 2009-013, Nonavailable Articles AGENCIES: Department of Defense (DoD), General Services... a final rule amending the Federal Acquisition Regulation (FAR) to revise the list of articles... The Buy American Act does not apply with respect to articles, materials, or supplies if...

  15. 76 FR 75875 - Defense Federal Acquisition Regulation Supplement; Open Source Software Public Meeting

    Science.gov (United States)

    2011-12-05

    ... Defense Acquisition Regulations System Defense Federal Acquisition Regulation Supplement; Open Source... regarding the use of open source software in DoD contracts. DATES: Public Meeting: January 12, 2012, from 10... for the discussions in the meeting. Please cite ``Public Meeting, DFARS--Open Source Software'' in all...

  16. 76 FR 48693 - Migratory Bird Hunting; Proposed Migratory Bird Hunting Regulations on Certain Federal Indian...

    Science.gov (United States)

    2011-08-08

    ... August 8, 2011 Part V Department of the Interior Fish and Wildlife Service 50 CFR Part 20 Migratory Bird Hunting; Proposed Migratory Bird Hunting Regulations on Certain Federal Indian Reservations and Ceded... RIN 1018-AX34 Migratory Bird Hunting; Proposed Migratory Bird Hunting Regulations on Certain...

  17. 75 FR 32642 - Defense Federal Acquisition Regulation Supplement; Ground and Flight Risk Clause (DFARS Case 2007...

    Science.gov (United States)

    2010-06-08

    ... Acquisition Regulation Supplement; Ground and Flight Risk Clause (DFARS Case 2007-D009) AGENCY: Defense... final rule amending the Defense Federal Acquisition Regulation Supplement (DFARS) to revise and combine... disadvantage small businesses. Most of the small businesses participating in these contracts do so as...

  18. 77 FR 44063 - Federal Acquisition Regulations; DARPA-New Mexico Tax Agreement

    Science.gov (United States)

    2012-07-26

    ... Federal Acquisition Regulations; DARPA-New Mexico Tax Agreement AGENCIES: Department of Defense (DoD... Regulation (FAR) to add the United States Defense Advanced Research Projects Agency (DARPA) to the list of agencies that have entered into separate tax agreements with the State of New Mexico (NM). The DARPA-NM...

  19. 76 FR 11411 - Defense Federal Acquisition Regulation Supplement; Multiyear Contracting (DFARS Case 2009-D026)

    Science.gov (United States)

    2011-03-02

    ... aircrew members or foreign language training); (4) Base services (e.g., ground maintenance, in-plane... Defense Acquisition Regulations System 48 CFR Part 217 RIN 0750-AG89 Defense Federal Acquisition Regulation Supplement; Multiyear Contracting (DFARS Case 2009-D026) AGENCY: Defense Acquisition...

  20. Federal Regulation of Gene Therapy: Who Will Save our Germline?

    OpenAIRE

    2003-01-01

    This paper will attempt to address some of these more complex issues involving human gene therapy and the encompassing regulations. The first section will deal with the science of gene therapy and will briefly touch upon the scientific hurdles that remain for scientists in this field, as this is important to understanding many of the ethical issues. This section will be divided into a basic genetic overview, a description of somatic gene therapy, and a summary of germline gene therapy. The se...

  1. Managing overlapping federal FMLA and state leave regulations.

    Science.gov (United States)

    Grebowski, Lucinda S

    2002-03-01

    The overlap between the Family and Medical Leave Act and state leave laws can create complications. Employers, particularly those with multistate operations, may wish to consider an outsourced absence management system, which can remove the burden of day-to-day administration and the need to stay abreast of changing state regulations. However, employers cannot outsource the responsibility to set broad policy toward absence management.

  2. 77 FR 43082 - Federal Acquisition Regulation; Information Collection; Commerce Patent Regulations

    Science.gov (United States)

    2012-07-23

    ... Regulation; Information Collection; Commerce Patent Regulations AGENCIES: Department of Defense (DOD... approved information collection requirement concerning Department of Commerce patent regulations. Public...: Submit comments identified by Information Collection 9000- 0095, Commerce Patent Regulations, by any...

  3. Medicaid program; refunding of federal share of overpayments made to Medicaid providers--HCFA. Final regulations.

    Science.gov (United States)

    1989-02-03

    This rule amends the Medicaid regulations to specify the requirements and procedures under which States are allowed 60 days following the date of discovery of an overpayment to a Medicaid provider to recover or attempt to recover the overpayment before the Federal share must be credited to HCFA. The Federal Government will share in any overpayments that the State documents it is unable to recover because the debts of the provider have been discharged in bankruptcy or the provider is out of business. The regulations implement section 9512 of the Consolidated Omnibus Budget Reconciliation Act of 1985.

  4. Regulating alcohol advertising: content analysis of the adequacy of federal and self-regulation of magazine advertisements, 2008-2010.

    Science.gov (United States)

    Smith, Katherine C; Cukier, Samantha; Jernigan, David H

    2014-10-01

    We analyzed beer, spirits, and alcopop magazine advertisements to determine adherence to federal and voluntary advertising standards. We assessed the efficacy of these standards in curtailing potentially damaging content and protecting public health. We obtained data from a content analysis of a census of 1795 unique advertising creatives for beer, spirits, and alcopops placed in nationally available magazines between 2008 and 2010. We coded creatives for manifest content and adherence to federal regulations and industry codes. Advertisements largely adhered to existing regulations and codes. We assessed only 23 ads as noncompliant with federal regulations and 38 with industry codes. Content consistent with the codes was, however, often culturally positive in terms of aspirational depictions. In addition, creatives included degrading and sexualized images, promoted risky behavior, and made health claims associated with low-calorie content. Existing codes and regulations are largely followed regarding content but do not adequately protect against content that promotes unhealthy and irresponsible consumption and degrades potentially vulnerable populations in its depictions. Our findings suggest further limitations and enhanced federal oversight may be necessary to protect public health.

  5. Regulating Alcohol Advertising: Content Analysis of the Adequacy of Federal and Self-Regulation of Magazine Advertisements, 2008–2010

    Science.gov (United States)

    Cukier, Samantha; Jernigan, David H.

    2014-01-01

    Objectives. We analyzed beer, spirits, and alcopop magazine advertisements to determine adherence to federal and voluntary advertising standards. We assessed the efficacy of these standards in curtailing potentially damaging content and protecting public health. Methods. We obtained data from a content analysis of a census of 1795 unique advertising creatives for beer, spirits, and alcopops placed in nationally available magazines between 2008 and 2010. We coded creatives for manifest content and adherence to federal regulations and industry codes. Results. Advertisements largely adhered to existing regulations and codes. We assessed only 23 ads as noncompliant with federal regulations and 38 with industry codes. Content consistent with the codes was, however, often culturally positive in terms of aspirational depictions. In addition, creatives included degrading and sexualized images, promoted risky behavior, and made health claims associated with low-calorie content. Conclusions. Existing codes and regulations are largely followed regarding content but do not adequately protect against content that promotes unhealthy and irresponsible consumption and degrades potentially vulnerable populations in its depictions. Our findings suggest further limitations and enhanced federal oversight may be necessary to protect public health. PMID:24228667

  6. Review of the current state of UAV regulations

    NARCIS (Netherlands)

    Stöcker, Elvira Claudia; Bennett, Rohan; Nex, Francesco; Gerke, Markus; Zevenbergen, Jaap

    2017-01-01

    UAVs-unmanned aerial vehicles-facilitate data acquisition at temporal and spatial scales that still remain unachievable for traditional remote sensing platforms. However, current legal frameworks that regulate UAVs present significant barriers to research and development. To highlight the

  7. Audit Risk Assessment in the Light of Current European Regulations

    OpenAIRE

    Ciprian-Costel Munteanu

    2015-01-01

    Recent European reforms on audit regulations have been motivated by efforts to increase audit quality, functioning and performance. We believe the adoption of Directive 2014/56 and Regulation 537/2014 strengthened the role of independent audit and risk committees, which will positively contribute towards audit quality. This paper aims to critically assess the status quo of audit risk assessment in current European standards and regulations, by conducting a theoretical analysis of ...

  8. Current status of radon and radium monitoring at the Federal University of Technology (UTFPR), PR, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Paschuk, Sergei A.; Correa, Janine N.; Kappke, Jaqueline; Schelin, Hugo R.; Denyak, Valeriy; Barbosa, Laercio; Perna, Allan F.N. [Universidade Tecnologica Federal do Parana (UTFPR), Curitiba, PR (Brazil)

    2011-07-01

    Numerous and systematic studies performed in different countries for many decades resulted in the explicit conclusion that radon exposure, as well as its progeny, is the main cause of lung cancer among non-smokers. All three natural radon isotopes ({sup 222}Rn, {sup 220}Rn and {sup 219}Rn) are produced in the three principal natural radioactive decay chains. Specifically, the {sup 222}Rn is produced by the decay series of {sup 238}U and proceeded from {alpha}-decay of {sup 226}Ra. Current work describes the present status and obtained results concerning indoor radon survey in dwellings, radon in water supply and soil gas tests performed by the Laboratory of Applied Nuclear Physics of the Federal University of Technology (UTFPR) within Curitiba urban area. For radon in air activity measurements, it was used polycarbonate etched track detectors such as LEXAN (GE) and CR-39, mounted in diffusion chambers. For soil gas measurements, the experimental setup was based on the Professional Radon Monitor (AlphaGUARD, Genitron/SAPHYMO) connected to the air pump with filter vessels and to specially developed in our Laboratory the Soil Gas Probe. In the case of radon tests in drinking water, the experimental setup was based on the AlphaGUARD Radon monitor and Electronic radon detector RAD7 (Durridge Company, Inc.) connected to special kit of glass vessels through the air pump. Obtained results permitted to identify few dwellings where radon concentration in air was found bigger than 600 Bq/m{sup 3} which is considered as the action level by most of the European Community and the World Health Organization (WHO). In the case of studied artesian wells, collected samples of water presented the average {sup 222}Rn activity about 60 Bq/L which is 6 times bigger than maximum level recommended by USEPA. Some artesian wells presented the radon activity of almost 200 Bq/L. More over, it was identified the radioactivity of radium ({sup 226}Ra) salts which are soluble in water and almost

  9. 75 FR 38675 - Federal Acquisition Regulation; FAR Case 2008-011, Government Property

    Science.gov (United States)

    2010-07-02

    ... Property AGENCIES: Department of Defense (DoD), General Services Administration (GSA), and National... the Federal Acquisition Regulation (FAR) to revise FAR part 45, Government Property, and its... corrects the previous FAR rule for part 45, Government Property, published under FAC 2005-17, FAR Case 2004...

  10. 77 FR 17352 - Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program

    Science.gov (United States)

    2012-03-26

    ... Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program Correction In rule document 2012...-Aside for Women-Owned Small Business (WOSB) Concerns Eligible Under the WOSB Program (APR 2012) (15 U.S... Disadvantaged Women- Owned Small Business Concerns. * * * * * Notice of Set-Aside for Economically...

  11. 77 FR 68699 - Defense Federal Acquisition Regulation Supplement: New Free Trade Agreement-Panama (DFARS Case...

    Science.gov (United States)

    2012-11-16

    ... Federal Acquisition Regulation Supplement: New Free Trade Agreement--Panama (DFARS Case 2012-D044) AGENCY... implement the United States-Panama Trade Promotion Agreement. This Trade Promotion Agreement is a free trade... Panama Free Trade Agreement (FTA). The FTA provides for-- Waiver of the applicability of the Buy American...

  12. 78 FR 37695 - Federal Acquisition Regulation; Free Trade Agreement (FTA)-Panama

    Science.gov (United States)

    2013-06-21

    ... 9000-AM43 Federal Acquisition Regulation; Free Trade Agreement (FTA)-Panama AGENCY: Department of... Promotion Agreement. This Trade Promotion Agreement is a free trade agreement that provides for mutually non... Panama to the definition of ``Free Trade Agreement country'' in multiple locations in the FAR. The Panama...

  13. 12 CFR 609.915 - Compliance with Federal Reserve Board Regulations B, M, and Z.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Compliance with Federal Reserve Board Regulations B, M, and Z. 609.915 Section 609.915 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT... (Equal Credit Opportunity), M (Consumer Leasing), and Z (Truth in Lending) (12 CFR parts 202, 213,...

  14. 78 FR 71528 - Federal Management Regulation (FMR); Transportation Payment and Audit

    Science.gov (United States)

    2013-11-29

    ...] RIN 3090-AJ39 Federal Management Regulation (FMR); Transportation Payment and Audit AGENCY: Office of... Part 102-118 as set forth below: PART 102-118--TRANSPORTATION PAYMENT AND AUDIT 0 1. The authority...-118.580 to read as follows: Sec. 102-118.580 May a TSP appeal a prepayment audit decision of the...

  15. 78 FR 18342 - Federal Acquisition Regulation; Submission for OMB Review; Change Order Accounting

    Science.gov (United States)

    2013-03-26

    ... Regulation; Submission for OMB Review; Change Order Accounting AGENCY: Department of Defense (DOD), General... collection requirement concerning change order accounting. A notice was published in the Federal Register at... Information Collection 9000- 0026, Change Order Accounting, by any of the following methods:...

  16. 75 FR 6669 - Federal Acquisition Regulation; Submission for OMB Review; Contractors' Purchasing Systems Reviews

    Science.gov (United States)

    2010-02-10

    ... contractors' purchasing systems reviews. A request for public comments was published in the Federal Register....cundiff@gsa.gov . SUPPLEMENTARY INFORMATION: A. Purpose The objective of a contractor purchasing system... Regulation; Submission for OMB Review; Contractors' Purchasing Systems Reviews AGENCIES: Department of...

  17. Tools Related to the Federal Tobacco Products Regulations: What Retailers Need to Know PSA (:30)

    Centers for Disease Control (CDC) Podcasts

    2010-09-16

    PSA to announce a new mobile text message program that will help raise retailers' awareness of the new federal tobacco regulations.  Created: 9/16/2010 by The CDC Division of News and Electronic Media and the FDA Center for Tobacco Products.   Date Released: 9/16/2010.

  18. 77 FR 76939 - Defense Federal Acquisition Regulation Supplement: Definition of Cost or Pricing Data (DFARS Case...

    Science.gov (United States)

    2012-12-31

    ... 0750-AH49 Defense Federal Acquisition Regulation Supplement: Definition of Cost or Pricing Data (DFARS... consistency with FAR changes addressing the definition of cost or pricing data which clarified the distinction... the DFARS to update the text addressing the definition of cost or pricing data by inserting the...

  19. 76 FR 61296 - Defense Federal Acquisition Regulation Supplement: Contracting With the Canadian Commercial...

    Science.gov (United States)

    2011-10-04

    ... October 1, 2010, the definitions in the Federal Acquisition Regulation (FAR) relating to cost or pricing... other than certified cost or pricing data.'' The new definition of these terms in the FAR is significant..., Definition of Cost or Pricing Data, are not yet implemented. Therefore, this rule includes conforming...

  20. 77 FR 2680 - Defense Federal Acquisition Regulation Supplement; Definition of Cost or Pricing Data

    Science.gov (United States)

    2012-01-19

    ... RIN 0750-AH49 Defense Federal Acquisition Regulation Supplement; Definition of Cost or Pricing Data... text addressing the definition of cost or pricing data. The DFARS changes are necessary to ensure... definition of cost or pricing data, published at 75 FR 53135 on August 30, 2010. II. Executive Orders...

  1. 77 FR 4631 - Defense Federal Acquisition Regulation Supplement: New Designated Country-Armenia (DFARS Case...

    Science.gov (United States)

    2012-01-30

    ... ``designated country'' at DFARS 252.225-7021, Trade Agreements, and 252.225-7045, Balance of Payments Program... ``Designated country'', revise paragraph (1) to read as follows: 252.225-7045 Balance of Payments Program... amending the Defense Federal Acquisition Regulation Supplement (DFARS) to add Armenia as a World Trade...

  2. 76 FR 67153 - Federal Acquisition Regulation; Submission for OMB Review; Payment by Electronic Fund Transfer

    Science.gov (United States)

    2011-10-31

    ... would enable the Government to make payments under the contract by electronic fund transfer (EFT). The... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF DEFENSE... Regulation; Submission for OMB Review; Payment by Electronic Fund Transfer AGENCY: Department of Defense (DOD...

  3. 76 FR 12357 - Federal Acquisition Regulation; Information Collection; Acquisition of Helium

    Science.gov (United States)

    2011-03-07

    ...; Docket 2011-0079; Sequence 5] Federal Acquisition Regulation; Information Collection; Acquisition of... requirement concerning acquisition of helium. Public comments are particularly invited on: Whether this... cite OMB Control No. 9000-0113, Acquisition of Helium, in all correspondence. Dated: February 24,...

  4. 75 FR 9604 - Federal Acquisition Regulation; Submission for OMB Review; Subcontracting Plans/Individual...

    Science.gov (United States)

    2010-03-03

    ... subcontracting plans/individual subcontract report. A request for public comments published in the Federal Register at 73 FR 21779 on April 22, 2008. No comments were received. Public comments are particularly... Regulation; Submission for OMB Review; Subcontracting Plans/Individual Subcontract Report...

  5. 77 FR 69626 - Federal Acquisition Regulation; Information Collection; Subcontracting Plans/Individual...

    Science.gov (United States)

    2012-11-20

    ... regarding an extension to this clearance published in the Federal Register at 75 FR 9604, on March 3, 2010... Regulation; Information Collection; Subcontracting Plans/Individual Subcontract Report (SF-294) AGENCIES... previously approved information collection requirement concerning subcontracting plans/individual...

  6. 76 FR 31416 - Federal Acquisition Regulation; Oversight of Contractor Ethics Programs

    Science.gov (United States)

    2011-05-31

    ... Federal Acquisition Regulation; Oversight of Contractor Ethics Programs AGENCY: Department of Defense (DoD... contractors have implemented the mandatory contractor business ethics program requirements. DATES: Effective... to Improve DoD's Oversight of Contractor Ethics Programs. The ethics program requirement flows from...

  7. 78 FR 38539 - Federal Acquisition Regulation; Applicability of the Senior Executive Compensation Benchmark

    Science.gov (United States)

    2013-06-26

    ... Federal Acquisition Regulation; Applicability of the Senior Executive Compensation Benchmark AGENCY..., 2011) of the application of the senior executive compensation benchmark amount. Section 803 expands to...'' screen. Please include your name, company name (if any), and ``FAR Case 2012-025'' on your...

  8. 76 FR 31415 - Federal Acquisition Regulation; Buy American Exemption for Commercial Information Technology...

    Science.gov (United States)

    2011-05-31

    ... 9000-AL62 Federal Acquisition Regulation; Buy American Exemption for Commercial Information Technology... from the Buy American Act for acquisition of information technology that is a commercial item. DATES...., because the rule simplifies the treatment of construction material that is also a commercial...

  9. 76 FR 60357 - Federal Regulations; OMB Circulars, OFPP Policy Letters, and CASB Cost Accounting Standards...

    Science.gov (United States)

    2011-09-29

    ... derived from 41 U.S.C. 1501. Cost Accounting Standards are rules governing the measurement, assignment... and 48 CFR Ch. 1 Federal Regulations; OMB Circulars, OFPP Policy Letters, and CASB Cost Accounting... Procurement Policy (OFPP) Policy Letters, and Cost Accounting Standards Board (CASB) Cost Accounting...

  10. 75 FR 80350 - Federal Travel Regulation; Removal of Privately Owned Vehicle Rates; Privately Owned Automobile...

    Science.gov (United States)

    2010-12-22

    ... date for the final rule published on November 29, 2010 at 75 FR 72965 remains November 29, 2010. The...-AJ09 Federal Travel Regulation; Removal of Privately Owned Vehicle Rates; Privately Owned Automobile Mileage Reimbursement When Government Owned Automobiles Are Authorized; Miscellaneous...

  11. 76 FR 30550 - Federal Management Regulation; Change in Consumer Price Index Minimal Value

    Science.gov (United States)

    2011-05-26

    ... ADMINISTRATION 41 CFR Part 102-42 RIN 3090-AJ12 Federal Management Regulation; Change in Consumer Price Index..., to reflect changes in the Consumer Price Index for the immediately preceding 3-year period. The... INFORMATION CONTACT: Mr. Robert Holcombe, Director, Asset Management Policy Division (202-501-3828...

  12. 78 FR 28756 - Defense Federal Acquisition Regulation Supplement: System for Award Management Name Changes...

    Science.gov (United States)

    2013-05-16

    ... 0750-AH87 Defense Federal Acquisition Regulation Supplement: System for Award Management Name Changes... System (EPLS) databases into the System for Award Management (SAM) database. DATES: Effective Date: May... effort to improve the management and promotion of electronic Government services and processes. The Act...

  13. 78 FR 73104 - Federal Travel Regulation (FTR); Agency Requirements for Payment of Expenses Connected With the...

    Science.gov (United States)

    2013-12-05

    ...] RIN 3090-AJ37 Federal Travel Regulation (FTR); Agency Requirements for Payment of Expenses Connected... family member. The employee may elect an alternate destination, but it must be approved by your agency...) The new CONUS location if in transit; or (c) An alternate destination as approved by the agency....

  14. 75 FR 47681 - Migratory Bird Hunting; Proposed Migratory Bird Hunting Regulations on Certain Federal Indian...

    Science.gov (United States)

    2010-08-06

    ... Interior Fish and Wildlife Service 50 CFR Part 20 Migratory Bird Hunting; Proposed Migratory Bird Hunting... INTERIOR Fish and Wildlife Service 50 CFR Part 20 RIN 1018-AX06 Migratory Bird Hunting; Proposed Migratory Bird Hunting Regulations on Certain Federal Indian Reservations and Ceded Lands for the 2010-11...

  15. 78 FR 46792 - Federal Acquisition Regulation; Least Developed Countries That Are Designated Countries

    Science.gov (United States)

    2013-08-01

    ... 9000-AM62 Federal Acquisition Regulation; Least Developed Countries That Are Designated Countries... Representative (USTR) to the list of least developed countries that are designated countries under the Trade... President to designate least developed countries as eligible countries under the Trade Agreements Act...

  16. 75 FR 71564 - Defense Federal Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS...

    Science.gov (United States)

    2010-11-24

    ... Regulation Supplement; Contractor Insurance/Pension Review (DFARS Case 2009-D025) AGENCY: Defense Acquisition.../Pension Review from Procedures, Guidance, and Information (PGI) to the Defense Federal Acquisition... requirements for Contractor Insurance/ Pension Review to DFARS 242.7302 from PGI 242.7302. DoD published a...

  17. 76 FR 78874 - Defense Federal Acquisition Regulation Supplement: Title 41 Positive Law Codification-Further...

    Science.gov (United States)

    2011-12-20

    ... Positive Law Codification--Further Implementation (DFARS Case 2012- D003) AGENCIES: Defense Acquisition... Defense Federal Acquisition Regulation Supplement to conform statutory titles to the new Positive Law Codification of Title 41, United States Code, ``Public Contracts.'' DATES: Comment Date: Comments on the...

  18. 75 FR 82575 - Federal Acquisition Regulation; Personal Identity Verification of Contractor Personnel

    Science.gov (United States)

    2010-12-30

    ... respondents stated that they have concerns over what happens when a contractor claims to have lost an identity... Federal Acquisition Regulation; Personal Identity Verification of Contractor Personnel AGENCY: Department...) were in place and worked as intended. A ``CAC'' is the DoD term for a Personal Identity...

  19. 40 CFR 152.20 - Exemptions for pesticides adequately regulated by another Federal agency.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Exemptions for pesticides adequately... PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE REGISTRATION AND CLASSIFICATION PROCEDURES Exemptions § 152.20 Exemptions for pesticides adequately regulated by another Federal agency. The pesticides...

  20. 76 FR 55837 - Workshops To Discuss Revisions to Federal and Indian Coal Valuation Regulations: Advance Notice...

    Science.gov (United States)

    2011-09-09

    ... valuation methods for lessees that are coal cooperatives or for lessees that consume their coal. Comments on this issue were divided. The ONRR invites comments on whether separate valuation methods are needed for... Revisions to Federal and Indian Coal Valuation Regulations: Advance Notice of Proposed Rulemaking AGENCY...

  1. 78 FR 19467 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS...

    Science.gov (United States)

    2013-04-01

    ... Number: Defense Federal Acquisition Regulation Supplement (DFARS), Appendix I, DoD Pilot Mentor-Protege... purposes of the DoD Pilot Mentor-Protege Program have been met. The purposes of the Program are to (1) provide incentives to major DoD contractors to assist protege firms in enhancing their capabilities...

  2. 25 CFR 900.50 - What Federal laws, regulations, and Executive Orders apply to subcontractors?

    Science.gov (United States)

    2010-04-01

    ... INTERIOR, AND INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management Systems Procurement Management System Standards § 900.50 What Federal laws, regulations, and...

  3. 75 FR 28771 - Federal Acquisition Regulation; FAR Case 2009-027, Personal Identity Verification of Contractor...

    Science.gov (United States)

    2010-05-24

    ...: 9000-AL60 Federal Acquisition Regulation; FAR Case 2009-027, Personal Identity Verification of..., company name (if any), and ``FAR Case 2009-027'' on your attached document. Fax: 202-501-4067. Mail... over contractor CACs. A CAC is the DoD term for a Personal Identity Verification (PIV) card. A PIV...

  4. 77 FR 54872 - Federal Acquisition Regulation; Prioritizing Sources of Supplies and Services for Use by the...

    Science.gov (United States)

    2012-09-06

    ... consideration to using certain existing non-mandatory sources to leverage agency buying power and achieve... posted without change to http://www.regulations.gov , including any personal and/or business confidential... INFORMATION: DoD, GSA, and NASA published a proposed rule in the Federal Register at 76 FR 34634 on June...

  5. 78 FR 64499 - Federal Acquisition Regulation; Submission for OMB Review; Contractor Use of Interagency Fleet...

    Science.gov (United States)

    2013-10-29

    ... management system vehicles. A notice was published in the Federal Register at 78 FR 23935, on April 23, 2013... Register on March 5, 2010 (75 FR 10267). No public comments were received in prior years that have... Regulation; Submission for OMB Review; Contractor Use of Interagency Fleet Management System Vehicles...

  6. 77 FR 66844 - Federal Acquisition Regulation; Submission for OMB Review; Evaluation of Export Offers

    Science.gov (United States)

    2012-11-07

    ... ``Evaluation of Export Offers.'' A notice was published in the Federal Register at 77 FR 35661, on June 14... Regulation; Submission for OMB Review; Evaluation of Export Offers AGENCIES: Department of Defense (DOD... the use of appropriate technological collection techniques or other forms of information...

  7. 75 FR 60690 - Defense Federal Acquisition Regulation Supplement (DFARS); Electronic Ordering Procedures (DFARS...

    Science.gov (United States)

    2010-10-01

    ... FAR 52.216-18, Ordering. The benefit of this rule to small business is that it will make electronic... Supplement (DFARS); Electronic Ordering Procedures (DFARS Case 2009-D037) AGENCY: Defense Acquisition... is proposing to amend the Defense Federal Acquisition Regulation Supplement to address...

  8. 76 FR 16629 - Federal Travel Regulation (FTR); Relocation Allowances-Relocation Income Tax Allowance (RITA) Tables

    Science.gov (United States)

    2011-03-24

    ... http://www.gsa.gov/relocationpolicy . Dated: March 21, 2011. Janet Dobbs, Director, Office of Travel... ADMINISTRATION Federal Travel Regulation (FTR); Relocation Allowances-- Relocation Income Tax Allowance (RITA... effective March 24, 2011. FOR FURTHER INFORMATION CONTACT: Mr. Ed Davis, Office of Governmentwide Policy...

  9. 77 FR 51026 - Federal Acquisition Regulation; Submission for OMB Review; Government Property

    Science.gov (United States)

    2012-08-23

    ... Regulation; Submission for OMB Review; Government Property AGENCY: Department of Defense (DOD), General... collection requirement concerning Government Property. A notice was published in the Federal Register at 76...) 501-1448 or email curtis.glover@gsa.gov . SUPPLEMENTARY INFORMATION: A. Purpose Property, as used...

  10. 50 CFR 20.110 - Seasons, limits, and other regulations for certain Federal Indian reservations, Indian Territory...

    Science.gov (United States)

    2010-10-01

    ... certain Federal Indian reservations, Indian Territory, and ceded lands. 20.110 Section 20.110 Wildlife and... regulations for certain Federal Indian reservations, Indian Territory, and ceded lands. This section provides... reservations, Indian Territory, and ceded lands. Editorial Note: For Federal Register citations...

  11. Enhanced current and voltage regulators for stand-alone applications

    DEFF Research Database (Denmark)

    Federico, de Bosio; Pastorelli, Michele; Antonio DeSouza Ribeiro, Luiz

    2016-01-01

    State feedback decoupling permits to achieve a better dynamic response for Voltage Source in stand-alone applications. The design of current and voltage regulators is performed in the discrete-time domain since it provides better accuracy and allows direct pole placement. As the attainable...... bandwidth of the current loop is mainly limited by computational and PWM delays, a lead compensator structure is proposed to overcome this limitation. The design of the voltage regulator is based on the Nyquist criterion, verifying to guarantee a high sensitivity peak. Discrete-time domain implementation...

  12. A summarized discussion of current good manufacturing practice regulations.

    Science.gov (United States)

    Allen, Loyd V

    2013-01-01

    In light of recent events and discussions of compounding pharmacy, it is important to discuss and understand the purpose of good manufacturing practices. This article provides a summary of the current Good Manufacturing Practice Regulations which were established by the U.S. Food and Drug Administration.

  13. Review of the current state of UAV regulations

    NARCIS (Netherlands)

    Stöcker, Elvira Claudia; Bennett, Rohan; Nex, Francesco; Gerke, Markus; Zevenbergen, Jaap

    2017-01-01

    UAVs-unmanned aerial vehicles-facilitate data acquisition at temporal and spatial scales that still remain unachievable for traditional remote sensing platforms. However, current legal frameworks that regulate UAVs present significant barriers to research and development. To highlight the importance

  14. 75 FR 41486 - Federal Acquisition Regulation; Information Collection; Reporting Purchases From Sources Outside...

    Science.gov (United States)

    2010-07-16

    ... Regulation; Information Collection; Reporting Purchases From Sources Outside the United States AGENCY... and approve an extension of a currently approved information collection requirement concerning reporting purchases from sources outside the United States. Public comments are particularly invited on...

  15. 75 FR 58388 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Science.gov (United States)

    2010-09-24

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--Quarterly... an extension of a currently approved information collection requirement concerning the American Recovery and Reinvestment Act--Quarterly Reporting for Prime Contractors. Public comments are...

  16. 75 FR 58387 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Science.gov (United States)

    2010-09-24

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--One-Time... an extension of a currently approved information collection requirement concerning the American Recovery and Reinvestment Act-Reporting Requirements--One Time- Reporting, Compensation...

  17. Labelling of electronic cigarettes: regulations and current practice

    Science.gov (United States)

    Buonocore, Federico; Marques Gomes, Ana C N; Nabhani-Gebara, Shereen; Barton, Stephen J; Calabrese, Gianpiero

    2017-01-01

    Background Over the past decade e-cigarettes have established themselves in the global market. E-cigarettes triggered much interest in relation to their content and efficacy as smoking cessation tools, but less attention has been paid to users and environmental safety warnings and guidance. Several regulations have been introduced to promote their safe handling and disposal. From May 2016, liquids and cartridges will be regulated by European Community Directives (ECDs) 2001/83/EC and 93/42/EEC, or 2014/40/EU if marketed as tobacco-related products. Currently, manufacturers and distributors must abide by the Chemical (Hazard Information and Packaging for Supply) Regulations 2009 (CHIP) or Classification, Labelling and Packaging Regulations (CLP), the latter replacing CHIP in June 2015. Objective In this work, the compliance of marketed e-liquids and e-cigarettes with current European Union and UK legislations is assessed. Results E-liquids and e-cigarettes (21 and 9 brands, respectively) were evaluated. Evidence of non-compliance was found in relation to the CHIP/CLP toxic (13%) and environmental (37%) pictograms, tactile warning (23%), nominal amount of solution (30%), supplier contact telephone number and address (40%). None of the evaluated e-cigarettes displayed information on the correct disposal/recycling of batteries in line with the ECD 2006/66/EC. Conclusions More stringent enforcement of regulations is needed to ensure not only the user's safety and awareness, but also the safeguarding of the environment. PMID:26790924

  18. 75 FR 25165 - Defense Federal Acquisition Regulation Supplement; Cost and Software Data Reporting System

    Science.gov (United States)

    2010-05-07

    ... reporting requirements that are essential for the DoD to estimate the cost of current and future weapon... and not cost allocations. The description will also show how the data from the offeror's accounting... Regulation Supplement; Cost and Software Data Reporting System AGENCY: Defense Acquisition Regulations...

  19. Results of operation and current safety performance of nuclear facilities located in the Russian Federation

    Science.gov (United States)

    Kuznetsov, V. M.; Khvostova, M. S.

    2016-12-01

    After the NPP radiation accidents in Russia and Japan, a safety statu of Russian nuclear power plants causes concern. A repeated life time extension of power unit reactor plants, designed at the dawn of the nuclear power engineering in the Soviet Union, power augmentation of the plants to 104-109%, operation of power units in a daily power mode in the range of 100-70-100%, the use of untypical for NPP remixed nuclear fuel without a careful study of the results of its application (at least after two operating periods of the research nuclear installations), the aging of operating personnel, and many other management actions of the State Corporation "Rosatom", should attract the attention of the Federal Service for Ecological, Technical and Atomic Supervision (RosTekhNadzor), but this doesn't happen. The paper considers safety issues of nuclear power plants operating in the Russian Federation. The authors collected statistical information on violations in NPP operation over the past 25 years, which shows that even after repeated relaxation over this period of time of safety regulation requirements in nuclear industry and highly expensive NPP modernization, the latter have not become more safe, and the statistics confirms this. At a lower utilization factor high-power pressure-tube reactors RBMK-1000, compared to light water reactors VVER-440 and 1000, have a greater number of violations and that after annual overhauls. A number of direct and root causes of NPP mulfunctions is still high and remains stable for decades. The paper reveals bottlenecks in ensuring nuclear and radiation safety of nuclear facilities. Main outstanding issues on the storage of spent nuclear fuel are defined. Information on emissions and discharges of radioactive substances, as well as fullness of storages of solid and liquid radioactive waste, located at the NPP sites are presented. Russian NPPs stress test results are submitted, as well as data on the coming removal from operation of NPP

  20. 75 FR 32635 - Defense Acquisition Regulations System; Defense Federal Acquisition Regulation Supplement...

    Science.gov (United States)

    2010-06-08

    ... Regulation Supplement; Balance of Payments Program Exemption for Commercial Information Technology... implement in the clauses at 252.225-7044, Balance of Payments Program--Construction Material, and 252.225-7045, Balance of Payments Program--Construction Material under Trade Agreements, the exemption from...

  1. Acid rain compliance and coordination of state and federal utility regulation

    Energy Technology Data Exchange (ETDEWEB)

    Nordhaus, R.R. [Van Ness, Feldman, and Curtis, P.C., Washington, DC (United States)

    1993-07-01

    The Clean Air Act Amendments of 1990 (CAAA) impose new controls on emissions by electric utilities of the two major precursors of acid rain: sulfur dioxide and oxides of nitrogen. Utilities, and the utility holding company systems and power pools of which they are members, will be subject to extensive and costly compliance obligations under the new stature. Most of these utilities, utility systems, and power pools are regulated by more than one utility regulatory authority. Utility regulators will need to coordinate their policies for ratemaking and for review of acid rain compliance strategies if least-cost solutions are to be implemented without imposing on rate payers and utility shareholders the costs and risks of inconsistent regulatory determinations. This article outlines the scope of the coordination problem and spells out possible approaches that utility regulators may take in dealing with it. Topics covered include the following: the 1990 Clean Air Act Amendments; acid rain (SO2); acid rain (NOx); costs of compliance; implications for utility regulation - federal and state utility regulatory framework; potential jurisdictional conflicts under existing state/federal utility regulatory scheme - single utility, holding companies, power pools; Utility regulatory issues under the 1990 amendments - planning conflicts, operational conflicts; methods for dealing with potential jurisdictional conflicts; coordination mechanisms - informal consultation, rulemaking,coordination of adjudicatory proceedings, FERC rate filings.

  2. Legal Regulation Of Citizens Of The Russian Federation Participation In The Electoral Process At The Present Stage

    Directory of Open Access Journals (Sweden)

    Dmitriy O. Ezhevskiy

    2015-03-01

    Full Text Available In the present article author analyzes features of the current legislation about elections in the Russian Federation with the latest changes. We consider legal regulation of Russian citizens participation in the electoral process, as well as the role and importance of the state and its agencies as participants in the electoral process. Legitimacy of free and fair elections at all levels requires that they relied on a solid legal basis, created in the democratic rule of law. Ongoing in the Russian Federation reforms of the political and economic systems are designed through the democratization of all aspects of life to connect the interests of the individual and society, in fact, to put people at the center of social development, to provide them decent living conditions, freedom and the opportunity to participate in managing state affairs both directly and through their elected representatives. According to the author, in terms of democratization of state and society an important role is played by the polling relationships, based on the electoral law and the electoral process in the Russian Federation. In conclusion, author underlines that the distinguishing feature of the legal status of election commissions, government agencies, local governments, enterprises, organizations, institutions, media, as well as their officials is that they have the right to participate in the electoral legal relations strictly within their authority and cannot go beyond these powers, no matter what reasons motivated the necessity and expediency of actions that go beyond the law.

  3. Federal regulation of the pipeline industry. A summary review. Technical report, Task 2

    Energy Technology Data Exchange (ETDEWEB)

    Banks, W. F.

    1977-05-31

    The principal purposes of this report are to identify the jurisdiction areas of the federal pipeline regulating agencies, and to examine the amenability of the regulatory system to the introduction of energy-conservative new technology into the pipeline industry. The history, scope, and agency structure of state and federal regulation are recounted and some gaps, overlaps, and ambiguities are identified. The only significant inhibitory effects upon technological innovation are found to derive from the FPC and ICC limits upon profit, the 1941 Justice Department consent decree limiting dividends to shipper-owned pipelines, and the income tax rules governing recovery of investment credits and startup losses. Effects of these limits are explored by simulation studies using the Systems, Science and Software pipeline economic model (PEM). Two new concepts of regulation are proposed which would neutralize the inhibitory effect of the present regulatory system and would motivate pipeline operators to conserve energy: one, the use of a national equivalent value in the economic trade-off analyses which justify entry of a technological innovation into the rate base (valuation); and two, a valuation allowance which would reverse the presently often-existing situation and insure that the pipeline operator would realize a greater profit from saving energy than from wasting it.

  4. The Federal Communications Commission: Current Structure and Its Role in the Changing Telecommunications Landscape

    Science.gov (United States)

    2009-05-14

    4 FCC Structure .......................................................................................................................6...for additional information on the history of the FCC. The Federal Communications Commission Congressional Research Service 6 FCC Structure The

  5. Benefit-cost analysis of DOE's Current Federal Program to increase hydrothermal resource utilization. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1981-12-10

    The impact of DOE's Current Federal Program on the commercialization of hydrothermal resources between 1980 and 2000 is analyzed. The hydrothermal resources of the United States and the types of DOE activities used to stimulate the development of these resources for both electric power and direct heat use are described briefly. The No Federal Program and the Current Federal Program are then described in terms of funding levels and the resultant market penetration estimates through 2000. These market penetration estimates are also compared to other geothermal utilization forecasts. The direct benefits of the Current Federal Program are next presented for electric power and direct heat use applications. An analysis of the external impacts associated with the additional hydrothermal resource development resulting from the Current Federal Program is also provided. Included are environmental effects, national security/balance-of-payments improvements, socioeconomic impacts and materials requirements. A summary of the analysis integrating the direct benefits, external impacts and DOE program costs concludes the report.

  6. Audit Risk Assessment in the Light of Current European Regulations

    Directory of Open Access Journals (Sweden)

    Ciprian-Costel Munteanu

    2015-06-01

    Full Text Available Recent European reforms on audit regulations have been motivated by efforts to increase audit quality, functioning and performance. We believe the adoption of Directive 2014/56 and Regulation 537/2014 strengthened the role of independent audit and risk committees, which will positively contribute towards audit quality. This paper aims to critically assess the status quo of audit risk assessment in current European standards and regulations, by conducting a theoretical analysis of different aspects of audit risk. Our main objective is to stress the importance of detecting inherent and control risk, which lead to material misstatement at the assertion level. They need to be assessed so as to determine the nature, timing and extent of further audit procedures necessary to obtain sufficient appropriate audit evidence. These pieces of evidence enable the auditor to express an opinion on the financial statements at an acceptably low level of audit risk. Therefore, we point to the fact that researchers as well as practitioners and policymakers have to be careful when using audit tools and assessing risk levels, as their conclusions continuously shape the regulations.

  7. Smokeless tobacco marketing and sales practices in Appalachian Ohio following federal regulations.

    Science.gov (United States)

    Klein, Elizabeth G; Ferketich, Amy K; Abdel-Rasoul, Mahmoud; Kwan, Mei-Po; Kenda, Loren; Wewers, Mary Ellen

    2012-07-01

    Smokeless tobacco (ST) use is increasingly prevalent among poor and vulnerable groups, especially rural males. Access to tobacco products, as well as marketing messages, is associated with tobacco usage. In June 2010, the Tobacco Control Act (TCA) marked the beginning of federal regulation of the sale and marketing of tobacco products--including ST. The goal of this study was to describe marketing practices over time and to provide early assessment of the federal regulation in rural tobacco-licensed retail outlets. Observational data were collected from a sample of retail outlets within three Ohio Appalachian counties. From an estimated 300 retail establishments, a stratified random sample was drawn (n = 86). Trained observers surveyed the sales and marketing of tobacco products. Baseline surveys were conducted between November 2009 and May 2010 before the TCA; follow-up surveys were repeated in August 2010. Follow-up surveys were completed for 79 tobacco-licensed retail outlets. The majority of retail outlets were gas stations or convenience stores. Compared with baseline, there was a significant reduction in the frequency of exterior and interior advertisements observed after the TCA (p increase in ST brands advertised suggests that advertising remains a clear presence in retail outlets in Appalachian Ohio.

  8. Federal trade commission regulation of food advertising to children: possibilities for a reinvigorated role.

    Science.gov (United States)

    Mello, Michelle M

    2010-04-01

    Growing awareness of the role that food and beverage advertising plays in the epidemic of childhood obesity has prompted calls for stricter oversight of advertising practices. The food and beverage industries have taken voluntary steps in this direction, but many commentators have called for increased government regulation. The mission of the Federal Trade Commission (FTC) makes it an obvious candidate to lead a new regulatory effort. However, the FTC has a troubled history in the area of children's advertising regulation, and several political and legal factors constrain its ability to act. This article reviews those obstacles as well as the opportunities that exist at present to expand FTC oversight of food advertising to children. The FTC has considerable latitude to regulate individual food advertisements more rigorously, either on the basis that they are deceptive or on the basis that they are unfair. Broader rule making under the unfairness authority would require congressional intervention to expand the FTC's scope of authority, but there exist possibilities for rule making under the deception doctrine. Finally, the FTC could strengthen its efforts to encourage the food industry to regulate its own advertising practices more stringently and could provide mechanisms for making voluntary initiatives more meaningful.

  9. 78 FR 56230 - Federal Acquisition Regulation; Information Collection; Reporting Purchases From Sources Outside...

    Science.gov (United States)

    2013-09-12

    ... Regulation; Information Collection; Reporting Purchases From Sources Outside the United States AGENCY... request to review and approve an extension of a currently approved information collection requirement concerning reporting purchases from sources outside the United States. DATES: Submit comments on or before...

  10. 75 FR 58389 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Science.gov (United States)

    2010-09-24

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--One Time... and approve an extension of a currently approved information collection requirement concerning the American Recovery and Reinvestment Act-Reporting Requirements--One Time Reporting Requirements for...

  11. 75 FR 58390 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Science.gov (United States)

    2010-09-24

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--One-Time... extension of a currently approved information collection requirement concerning the American Recovery and... particularly invited on: Whether this collection of information is necessary for the proper performance...

  12. 77 FR 12069 - Intent To Request Renewal From OMB of One Current Public Collection of Information: Federal...

    Science.gov (United States)

    2012-02-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND... their aircraft against acts of criminal violence or air piracy. With the enactment of Vision 100... collected to assess the qualifications and suitability of prospective and current FFDOs through an...

  13. 76 FR 34634 - Federal Acquisition Regulation; Prioritizing Sources of Supplies and Services for Use by the...

    Science.gov (United States)

    2011-06-14

    ... Strategic Sourcing Initiative (FSSI) agreements). The existing contracts and instruments are not listed in...) under Federal Supply Schedule contracts (e.g., Federal Strategic Sourcing Initiative (FSSI) agreements...

  14. Development and regulation of biosimilars: current status and future challenges.

    Science.gov (United States)

    Tsiftsoglou, Asterios S; Ruiz, Sol; Schneider, Christian K

    2013-06-01

    Biologic medicinal products developed via rDNA technology as recombinant protein-based medicines that have been in clinical use since the early 1980s as original biopharmaceuticals have greatly contributed to the therapy of severe metabolic and degenerative diseases. The recent expiration of the data protection or patents for most of them created opportunities for the development of copy versions of original biopharmaceuticals with similar biologic activity (termed biosimilars). Production of these new products is expected to meet worldwide demand, promote market competition, maintain the incentives for innovation, and sustain the healthcare systems. The licencing of these products, however, relies on the experience gained with the original biopharmaceuticals. Critical issues related to this class of medicinal products include their terminology (to avoid confusion with generics and non-innovator copy versions that have not been tested according to the biosimilar guidelines), manufacturing, and regulation. The European Union (EU) has been the first to establish a regulatory framework for marketing authorization application (MAA) and has named these products biosimilars, a term also recently adopted by the US FDA. Unlike the conventional, more common small molecular weight human medicines and chemical generics, protein-based medicines exhibit higher molecular weight, complexity in structure and function that can be affected by changes in the manufacturing process. Therefore, biosimilars represent a relatively heterogeneous class of medicinal products that make their regulation quite challenging. According to the current understanding in the EU, a biosimilar is a copy version of an already authorized biopharmaceutical (or reference product) with similar biologic activity, physicochemical characteristics, efficacy, and safety, based on a full comparability exercise at quality, preclinical and clinical level to ensure similar efficacy and safety. Guidance has been

  15. Identification of Federal Aviation Administration regulations and procedures that impact fuel consumption

    Energy Technology Data Exchange (ETDEWEB)

    Mckinly, J.B.

    1979-10-01

    The impact of the Federal Aviation Regulations (FARs) on fuel conservation in the air-transportation system. To date there exist over 89 identifiable fuel-conservation program and research areas. Operational constraints in the areas of FARs and Air Traffic Control (ATC), which hinder further fuel savings in any of the 89 program and research areas, are identified. The nature of this investigation presents an update of analyses from previous FAA, DOE, and NASA publications from a DOE viewpoint. The short duration and cost constraints of this study did not allow an assessment of safety, social, or any of the broader impacts of the regulations. However, this study was not intended to solve all of the regulatory problems. Rather, this was a cursory review of the FARs intended to pinpoint those fuel inefficient regulations which could be changed to improve the overall fuel-conservation effort in the air transportation industry. The program and research areas identified as being negatively impacted by FARs were analyzed to quantify the fuel savings available through revision or removal of those constraints. A recommended list of new R and D initiatives are proposed in order to improve fuel efficiency of the FARs in the air-transportation industry.

  16. Comparison of resonant current regulators for DFIG during grid voltage distortion

    Institute of Scientific and Technical Information of China (English)

    Yi-peng SONG; Heng NIAN

    2013-01-01

    We investigate two different kinds of resonant current regulators for a doubly fed induction generator (DFIG) under distorted grid voltage conditions:proportional integral resonant (PIR) regulator with traditional resonant part and vector propor-tional integral (VPI) regulator with VPI resonant part. Based on the mathematical model of DFIG under distorted grid voltage, the transfer function and frequency response characteristics of the two current regulators are analyzed and compared. The superiority of the VPI current regulator over the PIR regulator is pointed out, and the influence of discretization methods on the performance of the resonant current regulator is studied. All the results are validated by MATLAB simulation and experiments.

  17. Redox regulation in malaria: current concepts and pharmacotherapeutic implications.

    Science.gov (United States)

    Goyal, M; Alam, A; Bandyopadhyay, U

    2012-01-01

    Malaria imposes a serious threat to human and becomes more prevalent due to the emergence of drug resistant parasite. Understanding of the underlying mechanism of drug resistance and identification of novel drug targets are key effective processes for the management of malaria. Malaria parasite is highly susceptible to oxidative stress but lives in a pro-oxidant rich environment containing oxygen and iron, which produce a large amount of reactive oxygen species. Management of oxidative stress in malaria parasite is tightly regulated through active redox and antioxidant defense systems. The elevation of oxidative stress as a result of inhibition of any component of this defense system leads to redox imbalance and ultimately parasite death. Therefore, redox system plays an indispensable role for the survival of parasite within the host. Identification of key molecules, which disrupt parasite redox balance by altering key redox reactions and promote oxidative stress in parasites, would be an effective approach to develop novel antimalarial drugs. During the last few decades, contributions by researchers around the globe provide even better understanding of redox biology of malaria parasite. Here, in this review, we are highlighting the knowledge gathered so far regarding the essential redox-active processes and their components in malaria parasite to overcome elevated oxidative insults. We have also given maximum efforts to enlist currently used redox-active antimalarials, their mode of action and pharmacotherapeutic implications.

  18. Factors affecting the regulation of pacing: current perspectives

    Directory of Open Access Journals (Sweden)

    Mauger AR

    2014-09-01

    Full Text Available Alexis R Mauger Endurance Research Group, School of Sport and Exercise Sciences, Faculty of Science, University of Kent, Chatham, UK Abstract: During prolonged dynamic and rhythmic exercise, muscular pain and discomfort arises as a result of an increased concentration of deleterious metabolites. Sensed by peripheral nociceptors and transmitted via afferent feedback to the brain, this provides important information regarding the physiological state of the muscle. These sensations ultimately contribute to what is termed "exercise-induced pain". Despite being well recognized by athletes and coaches, and suggested to be integral to exercise performance, this construct has largely escaped attention in experimental work. This perspective article highlights the current understanding of pacing in endurance performance, and the causes of exercise-induced pain. A new perspective is described, which proposes how exercise-induced pain may be a contributing factor in helping individuals to regulate their work rate during exercise and thus provides an important construct in pacing. Keywords: pain, exercise-induced pain, discomfort, exercise performance, self-paced

  19. 78 FR 68831 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS...

    Science.gov (United States)

    2013-11-15

    ... Single Process Initiative (SPI) processes as alternatives to military or Federal specifications and... Government acceptance of an SPI process as a valid replacement for a military or Federal specification or... specifications; and/or Single Process Initiative (SPI) processes in lieu of military or Federal...

  20. 78 FR 30784 - Removal of References to Credit Ratings in Certain Regulations Governing the Federal Home Loan Banks

    Science.gov (United States)

    2013-05-23

    ... requirements based on credit ratings found in parts 1267 (Federal Home Loan Bank Investments), 1269 (Standby... rulemakings to remove references to and requirements based on NRSRO credit ratings in the Bank AMA regulations... (vi) re-emphasized and promoted sound and effective governance, (credit) risk management,...

  1. 76 FR 71890 - Federal Travel Regulation (FTR); Payment of Expenses Connected With the Death of Certain Employees

    Science.gov (United States)

    2011-11-21

    ... Special Agent Samuel Hicks Families of Fallen Heroes Act, codified at 5 U.S.C. 5724d, to allow agencies to... to an alternate residence destination? Yes, if the head of the agency concerned (or a designee...] RIN 3090-AJ21 Federal Travel Regulation (FTR); Payment of Expenses Connected With the Death of...

  2. 76 FR 71928 - Defense Federal Acquisition Regulation Supplement; Updates to Wide Area WorkFlow (DFARS Case 2011...

    Science.gov (United States)

    2011-11-21

    ... Contractor shall-- (1) Have a designated electronic business point of contact in the Central Contractor... and receiving reports in electronic format. DATES: Comments on the proposed rule should be submitted... procedures in the Defense Federal Acquisition Regulation Supplement (DFARS) for electronic submission...

  3. 77 FR 194 - Federal Acquisition Regulation; Time-and-Materials and Labor-Hour Contracts for Commercial Items

    Science.gov (United States)

    2012-01-03

    ... material; (4) Clarify contract types; (5) Potential for rule to limit the use of T&M contracts; (6...) The ordering activity shall specify the order type (i.e., firm-fixed price, time- and-materials, or... RIN 9000-AL74 Federal Acquisition Regulation; Time-and-Materials and Labor-Hour Contracts...

  4. FEDERAL SUPPORT OF SCIENTIFIC INQUIRY IN THE UNITED STATES: CURRENT EVOLUTION UNDER THE POLITICAL STRUGGLE

    Directory of Open Access Journals (Sweden)

    I. A. Istomin

    2016-01-01

    Full Text Available 2000’s and 2010’s witnessed diminishing margin of the United States in science and technology. Meanwhile, the U.S. remains a clear leader in this fi eld. Major driving force of the country’s success in the second half of the ХХ century remained assertive federal science policy. The article seeks to identify major trends in evolution of the U.S. science policy and the reasons behind relative decline of the level of budget support of the scientifi c research. The author studies evolution of the policies of George Bush and Barack Obama, as well as the views of Democrats and Republicans in the House of Representatives and the Senate. The article also examines the input into the federal policy of the governmental bodies, which are directly responsible for its implementation, as well as non-governmental organizations, which seek to advocate interests of scientists; it studies rising competition between the executive authorities and legislators for the recognition as a major champion of the academic community as well as American Recovery and Reinvestment Act.

  5. Comparative analysis of public service advertising regulation in Russian Federation and European countries

    Directory of Open Access Journals (Sweden)

    Nureeva Maria, R.

    2015-03-01

    Full Text Available In modern world public service advertising is a direct reflection of social values, humanistic relationships between people, level of cultural development of the society. The aim of PSA is to form social challenges in the society’s mind, to lead to reforms in social sphere. Underestimation and inattentiveness towards social problems could lead to loss of moral values, destruction of culture and forming the basis for aggravation in relation between different levels of society. The tasks of the research are the following: to analyze the legislative base of public service advertising, to determine their strengths and weaknesses; to find out typical problems arising while PSA realization in Russia and Europe; to determine the main obstacles, preventing from creation of efficient and qualitative PSA and to find out and provide the measures of creating an efficient and qualitative public service advertising. In the first part of the paper we compare PSA regulation, sort out PSA legislative and practical issues in Russia and Europe. In the second part we consider the process of efficient PSA realization. For this purpose there were investigated the main obstacles on the way of realization of PSA strategy in Russia and Europe, possibilities of application of marketing mix approach. Though the level of social activity has increased in Russia especially in recent years, PSA market is only in the process of formation – there are huge potentials for investigations, initiatives and improvements. We could conclude that modern PSA legal base of Russian Federation restrains the development of PSA in our country and puts obstacles in the way of PSA participants: government, non-commercial organizations and businesses. In comparison with EU our country fails behind European countries both in the level of legislative regulation and practical experience. The most important difference between PSA practice in Russia and in Europe is that in Europe there is clear

  6. How Should Risk-Based Regulation Reflect Current Public Opinion?

    Science.gov (United States)

    Pollock, Christopher John

    2016-08-01

    Risk-based regulation of novel agricultural products with public choice manifest via traceability and labelling is a more effective approach than the use of regulatory processes to reflect public concerns, which may not always be supported by evidence.

  7. The Regulation of Health Requirements for Police and Current Problems

    National Research Council Canada - National Science Library

    Ramazan Akçan; Mahmut Şerif Yıldırım; Aykut Lale; Abdurrahman İsak; Mehmet Cavlak; Aysun Balseven Odabaşı; Ali Rıza Tümer

    2017-01-01

    Introduction: Forensic medicine specialists might prepare reports about health conditions of candidates for Police Organization or assessment of organization's staff based on The Regulation of Health Requirements for Police...

  8. 76 FR 14570 - Federal Acquisition Regulation; Disclosure and Consistency of Cost Accounting Practices for...

    Science.gov (United States)

    2011-03-16

    ... Federal Register at 75 FR 34283 on June 16, 2010, to maintain consistency between CAS and FAR in matters... Practices--Foreign Concerns, in CAS-covered contracts and subcontracts awarded to foreign concerns (73 FR... amending 48 CFR parts 30 and 52, which was published in the Federal Register at 75 FR 34283 on June...

  9. 78 FR 80376 - Federal Acquisition Regulation; Prioritizing Sources of Supplies and Services for Use by the...

    Science.gov (United States)

    2013-12-31

    ... Comments 1. Federal Strategic Sourcing Initiative (FSSI) Blanket Purchase Agreement (BPA) for Office... business entities with the concept and practice of strategic sourcing as evidenced through FSSI agreements... contracts (e.g., Federal Strategic Sourcing Initiative (FSSI) agreements accessible at http://www.gsa.gov...

  10. 76 FR 9968 - Regulation for the Enforcement of Federal Health Care Provider Conscience Protection Laws

    Science.gov (United States)

    2011-02-23

    ... performance of induced abortions, or make arrangements for the provision of such training. For the purposes of... the Federal Register on December 19, 2008. The Rule contained definitions of terms used in the federal...--from discriminating against any applicant or employee in hiring, discipline, promotion, termination, or...

  11. 77 FR 43078 - Federal Acquisition Regulation; Information Collection; Central Contractor Registration

    Science.gov (United States)

    2012-07-23

    ... secure and encrypted data with Federal agency finance offices to facilitate paperless payments through... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE... Office of Management and Budget (OMB) a request to review and approve an extension of a...

  12. 78 FR 12316 - Federal Acquisition Regulation; Information Collection; Central Contractor Registration

    Science.gov (United States)

    2013-02-22

    ... secure and encrypted data with Federal agency finance offices to facilitate paperless payments through... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE... Office of Management and Budget (OMB) a request to review and approve an extension of a...

  13. The Impact of Federal Regulations on Research Management in Colleges and Universities: Overview and Summaries.

    Science.gov (United States)

    Perkins, John A.; And Others

    The University of California Research Management Improvement Project (RMIP) was initiated to point out federal requirements and their impacts on the educational institution. The findings are contained in nine separate reports covering case flow; environmental health and safety; federal procurement requirements; financial management: budgeting and…

  14. 18 CFR 367.2420 - Account 242, Miscellaneous current and accrued liabilities.

    Science.gov (United States)

    2010-04-01

    ..., FEDERAL POWER ACT AND NATURAL GAS ACT Balance Sheet Chart of Accounts Current and Accrued Liabilities... Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE PUBLIC...

  15. Federal regulation on the handling of substances constituting a hazard to water; Bundeseinheitliche Regelung des Umgangs mit wassergefaehrdenden Stoffen

    Energy Technology Data Exchange (ETDEWEB)

    Hollaender, Robert; Unnerstall, Herwig; Skiba, Katja; Katscher, Henriette; Kochmann, Linda; Enderlein, Frank [Leipzig Univ. (Germany). Professur fuer Umwelttechnik und -management; Helmholtzzentrum fuer Umweltforschung - ufz, Leipzig (Germany). Dept. Umwelt- und Planungsrecht; Sachverstaendigenorganisation AGU-TSO e.V., Bergen b. Auerbach (Germany)

    2010-03-15

    Subject of the research project was preliminary work for a draft of the federal ordinance on the handling of substances constituting a hazard to water. Basis was the draft for an Environmental Code by the Federal Ministry for the Environment from 25. June 2007 and 03. July 2008, Part II on water management. This report includes an analysis of the existing ordinances of the Laender (to be replaced by the new federal ordinance), a survey on problems with their enforcement, an analysis of European Directives on relevant implementation requirements, an analysis of the relation to the legislation on construction products, a comparison to regulations of other European Countries for the protection of water against hazardous substances, an approach for obligations of an ordinance, a preliminary draft of an ordinance, a concept for a system of related Technical Rules and finally an evaluation of possible costs of operators and of additional tasks of authorities due to obligations in the preliminary draft. (orig.)

  16. Regulating compassion: an overview of Canada's federal medical cannabis policy and practice

    Directory of Open Access Journals (Sweden)

    Lucas Philippe G

    2008-01-01

    Full Text Available Abstract Background In response to a number of court challenges brought forth by Canadian patients who demonstrated that they benefited from the use of medicinal cannabis but remained vulnerable to arrest and persecution as a result of its status as a controlled substance, in 1999 Canada became the second nation in the world to initiate a centralized medicinal cannabis program. Over its six years of existence, this controversial program has been found unconstitutional by a number of courts, and has faced criticism from the medical establishment, law enforcement, as well as the patient/participants themselves. Methods This critical policy analysis is an evidence-based review of court decisions, government records, relevant studies and Access to Information Act data related to the three main facets of Health Canada's medicinal cannabis policy – the Marihuana Medical Access Division (MMAD; the Canadians Institute of Health Research Medical Marijuana Research Program; and the federal cannabis production and distribution program. This analysis also examines Canada's network of unregulated community-based dispensaries. Results There is a growing body of evidence that Health Canada's program is not meeting the needs of the nation's medical cannabis patient community and that the policies of the Marihuana Medical Access Division may be significantly limiting the potential individual and public health benefits achievable though the therapeutic use of cannabis. Canada's community-based dispensaries supply medical cannabis to a far greater number of patients than the MMAD, but their work is currently unregulated by any level of government, leaving these organizations and their clients vulnerable to arrest and prosecution. Conclusion Any future success will depend on the government's ability to better assess and address the needs and legitimate concerns of end-users of this program, to promote and fund an expanded clinical research agenda, and to work in

  17. Methods, systems and apparatus for synchronous current regulation of a five-phase machine

    Science.gov (United States)

    Gallegos-Lopez, Gabriel; Perisic, Milun

    2012-10-09

    Methods, systems and apparatus are provided for controlling operation of and regulating current provided to a five-phase machine when one or more phases has experienced a fault or has failed. In one implementation, the disclosed embodiments can be used to synchronously regulate current in a vector controlled motor drive system that includes a five-phase AC machine, a five-phase inverter module coupled to the five-phase AC machine, and a synchronous current regulator.

  18. 77 FR 17353 - Federal Acquisition Regulation; New Designated Country (Armenia) and Other Trade Agreements Updates

    Science.gov (United States)

    2012-03-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Part 52 RIN 9000-AM16..., Malta, the Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain,...

  19. 78 FR 70025 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

    Science.gov (United States)

    2013-11-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE..., withhold, or withdraw purchasing system approval at the conclusion of a purchasing system review. Withdrawal of purchasing system approval would necessitate Government consent to individual...

  20. The local property taxes and municipal federalism. Current and future inequity condition of Italian Property Taxation

    Directory of Open Access Journals (Sweden)

    Michele Argiolas

    2013-08-01

    Full Text Available The main purpose of this paper is to analyze and compare the current local tax on real estate and the future and assessing criticality. The tax base is calculated by applying calculation methods that differ depending on the type of property you must tax. For buildings used for residential, the tax base is calculated on the basis of the cadastral income; in the case of building land is rather used the market value of land and buildings and, for rent, rural manor. The land property values are always lower than market values, which is because some time trying to implement a revision of the class with the objective of bringing the two values. The reclass procedure has recently been adopted in the municipality of Milano where it was decided to reclass of buildings located within a few micro-climates for the most central, in which houses were originally built affordable housing to meet the housing needs of the social classes poor and that over time turned into mansions in the city center. From 1 January 2012, the Imu will come into force, only municipal tax, which replaces the current Ici; the two taxes differ in the higher fixed rate (7.6 ‰, which does not involve substantial modifications to the old system tax. In this way, the result will be to produce an increase in the tax burden without solving the inequalities of the old system but increasing the gap. The Implementation Act contains provisions which IMU when applied to allow municipalities to solve some problems present in the Ici.

  1. Federal environmental legislation in the U.S. for protection of wildlife and regulation of environmental contaminants.

    Science.gov (United States)

    Fairbrother, Anne

    2009-10-01

    The U.S. has a long history of legislation to protect wildlife, beginning with the Lacey Act of 1900. There are now over 170 Federal laws that regulate environmental activities which may affect wildlife. Two important laws are the Pittman-Robertson Act enacted in 1937 that authorizes a tax for wildlife management and the Fish and Wildlife Coordination Act passed in 1958 whose primary purpose is conservation of fish and wildlife, both of which continue to provide significant funding for wildlife management. Modern environmental regulations began by passage of the National Environmental Policy Act in 1969, followed by the Clean Water Act, Superfund, and other laws to regulate pesticides and toxics and clean up contaminated sites. International conventions regulate sale, use and disposal of toxics and ocean dumping. These laws and conventions should protect wildlife from unintended consequences of global industrialization.

  2. Current development of radon and radium monitoring at the Federal University of Technology (UTFPR)

    Energy Technology Data Exchange (ETDEWEB)

    Paschuk, Sergei A.; Correa, Janine N.; Kappke, Jaqueline; Claro, Flavia Del; Perna, Allan F.N.; Reque, Marilson; Levchuk, Leonid, E-mail: sergei@utfpr.edu.br, E-mail: janine_nicolosi@hotmail.com, E-mail: flavia_delclaro@yahoo.com.br [Universidade Federal Tecnologica do Parana (UTFPR), Curitiba, PR (Brazil); Denyak, Valeriy; Schelin, Hugo R. [Instituto de Pesquisa Pele Pequeno Principe, Curitiba, PR (Brazil); Rocha, Zildete; Santos, Talita O., E-mail: rochaz@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN-CNEN/MG), Belo Horizonte, MG (Brazil)

    2013-07-01

    The present work describes the principal results concerning the radon and radium measurements at Curitiba (PR) urban area during the last decade. The monitoring was performed in cooperation with the Center of Nuclear Technology Development (CDTN/CNEN). For radon in air activity measurements, it was used polycarbonate etched track detectors such as LEXAN and CR-39, mounted in diffusion chambers. For soil gas measurements, the experimental setup was based on the Professional AlphaGUARD Radon Monitor connected to the Soil Gas Probe, filter vessels and air pump (AlphaPUMP), following the recommended protocols elaborated in the Soil-Gas Radon Intercomparison Measurements performed at different Countries of the world. In the case of radon tests in drinking water, the experimental setup was based on the AlphaGUARD Radon monitor and Electronic Radon Detector RAD7 connected to a special kit of glass vessels through the air pump. The obtained results permitted to identify few dwellings where radon concentration in air was found bigger than 600 Bq/m{sup 3}, that is considered as the action level by most of the European Community and the World Health Organization (WHO). In the case of well water, collected samples presented the average Rn-222 activity of about 60 Bq/L, that is 6 times bigger than the maximum level recommended by USEPA. Some artesian wells presented radon activity of almost 200 Bq/L. More over, almost all water samples presented the radioactivity of radium (Ra-226) salts bigger than the upper limit for global alpha radioactivity of potable water established by the Norms and Regulation of the Brazilian Ministry of Health. (author)

  3. 77 FR 55475 - Federal Acquisition Regulation; Information Collection; Permits, Authorities, or Franchises

    Science.gov (United States)

    2012-09-10

    ... Regulation; Information Collection; Permits, Authorities, or Franchises AGENCY: Department of Defense (DOD... previously approved information collection requirement concerning permits, authorities, or franchises for..., Permits, Authorities, or Franchises, by any of the following methods: Regulations.gov :...

  4. 77 FR 51804 - Federal Acquisition Regulation; Information Collection; Change Order Accounting

    Science.gov (United States)

    2012-08-27

    ... Regulation; Information Collection; Change Order Accounting AGENCY: Department of Defense (DOD), General... collection requirement concerning change order accounting. Public comments are particularly invited on... Collection 9000- 0026, Change Order Accounting by any of the following methods: Regulations.gov :...

  5. 77 FR 45612 - Federal Acquisition Regulation; Information Collection; Professional Employee Compensation Plan

    Science.gov (United States)

    2012-08-01

    ... Regulation; Information Collection; Professional Employee Compensation Plan AGENCY: Department of Defense... Compensation Plan. Public comments are particularly invited on: Whether this collection of information is..., Professional Employee Compensation Plan by any of the following methods: Regulations.gov :...

  6. Federal Regulations: Efforts to Estimate Total Costs and Benefits of Rules

    Science.gov (United States)

    2004-04-07

    workplace, economic, and tax compliance ) using various sources and sometimes making assumptions to adjust the results from previous studies . For...considered it inappropriate to include certain types of costs that the authors used (transfers and tax compliance ) . More recently, OMB has concluded...Developed 5 Environmental Regulations 5 Economic Regulations 6 Tax Compliance Regulations 7 Workplace Regulations 8 Hopkins’ Cautionary Notes 8 OMB Reports

  7. GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization

    DEFF Research Database (Denmark)

    Adelfinger, L; Turecek, R; Ivankova, K

    2014-01-01

    released from the G-protein. Receptor-activated K+ currents desensitize in the sustained presence of agonist to avoid excessive effects on neuronal activity. Desensitization of K+ currents integrates distinct mechanistic underpinnings. GABAB receptor activity reduces protein kinase-A activity, which...... reduces phosphorylation of serine-892 in GABAB2 and promotes receptor degradation. This form of desensitization operates on the time scale of several minutes to hours. A faster form of desensitization is induced by the auxiliary subunit KCTD12, which interferes with channel activation by binding to the G......-protein βγ subunits. Here we show that the two mechanisms of desensitization influence each other. Serine-892 phosphorylation in heterologous cells rearranges KCTD12 at the receptor and slows KCTD12-induced desensitization. Likewise, protein kinase-A activation in hippocampal neurons slows fast...

  8. 78 FR 25445 - Federal Acquisition Regulation; Submission for OMB Review; Quality Assurance Requirements

    Science.gov (United States)

    2013-05-01

    ... Regulation; Submission for OMB Review; Quality Assurance Requirements AGENCY: Department of Defense (DOD... information collection requirement concerning quality assurance requirements. A notice was published in the..., Quality Assurance Requirements, by any of the following methods: Regulations.gov : http://www.regulations...

  9. 75 FR 65439 - Defense Federal Acquisition Regulation Supplement; Electronic Subcontracting Reporting System

    Science.gov (United States)

    2010-10-25

    ...-602-0350. Mail: Defense Acquisition Regulations System, Attn: Ms. Cassandra R. Freeman, OUSD (AT&L... be posted to http://www.regulations.gov . FOR FURTHER INFORMATION CONTACT: Ms. Cassandra R. Freeman... procurement. Clare M. Zebrowski, Editor, Defense Acquisition Regulations System. 0 Therefore, 48 CFR parts 219...

  10. 75 FR 48278 - Defense Federal Acquisition Regulation Supplement; Excessive Pass-Through Charges

    Science.gov (United States)

    2010-08-10

    ... Regulation Supplement; Excessive Pass-Through Charges AGENCY: Defense Acquisition Regulations System... ensures that pass-through charges on contracts or subcontracts that are entered into for or on behalf of... required DoD to prescribe regulations to ensure that pass-through charges on contracts or subcontracts...

  11. 75 FR 20825 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; DoD Pilot...

    Science.gov (United States)

    2010-04-21

    ... Regulation Supplement; DoD Pilot Mentor-Protege Program AGENCY: Defense Acquisition Regulations System... Acquisition Regulation Supplement (DFARS) Appendix I, DoD Pilot Mentor-Protege Program; OMB Control Number... Mentor-Protege Program have been met. The purposes of the Program are to (1) provide incentives to...

  12. Brushless DC motor Drive during Speed regulation with Current Controller

    Directory of Open Access Journals (Sweden)

    Bhikshalu Manchala

    2015-04-01

    Full Text Available Brushless DC Motor (BLDC is one of the best electrical drives that have increasing popularity, due to their high efficiency, reliability, good dynamic response and very low maintenance. Due to the increasing demand for compact & reliable motors and the evolution of low cost power semiconductor switches and permanent magnet (PM materials, brushless DC motors become popular in every application from home appliances to aerospace industry. The conventional techniques for controlling the stator phase current in a brushless DC drive are practically effective in low speed and cannot reduce the commutation torque ripple in high speed range. This paper presents the PI controller for speed control of BLDC motor. The output of the PI controllers is summed and is given as the input to the current controller. The BLDC motor is fed from the inverter where the rotor position and current controller is the input. The complete model of the proposed drive system is developed and simulated using MATLAB/Simulink software. The operation principle of using component is analysed and the simulation results are presented in this to verify the theoretical analysis.

  13. 76 FR 5292 - Alternatives to Use of Credit Ratings in Regulations Governing the Federal National Mortgage...

    Science.gov (United States)

    2011-01-31

    ............ Omnibus Trade Act of 2010 Dec. 29, 2010........ 3611 111-345......... Restore Online Shoppers' Confidence... From the Federal Register Online via the Government Publishing Office ] Vol. 76 Monday, No. 20... future cumulative lists (1993-2009) are and will be available online at...

  14. 77 FR 19128 - Defense Federal Acquisition Regulation Supplement: Separation of Combined Provisions and Clauses...

    Science.gov (United States)

    2012-03-30

    ... grammatical changes to paragraph (a) of 252.229-7005, Tax Exemptions (Spain). III. Executive Orders 12866 and... proposed rule in the Federal Register at 76 FR 71922 on November 21, 2011, to separate provisions and... (Spain)... 252.229-7013, Tax Exemptions (Spain)--Representation. Conforming changes are also required...

  15. 76 FR 60050 - Submission for OMB Review; Federal Acquisition Regulation; Standard Form 28, Affidavit of...

    Science.gov (United States)

    2011-09-28

    ... of Individual Surety. A request for public comments was published in the Federal Register at 76 FR... at 76 FR 22706, April 22, 2011 and two comments were received. Both commenters support the extension... show a net worth not less than the penal amount of the bond on the SF 28. It is an elective decision...

  16. 76 FR 39240 - Federal Acquisition Regulation; Encouraging Contractor Policies To Ban Text Messaging While Driving

    Science.gov (United States)

    2011-07-05

    ... employees about the safety risks associated with texting while driving. As a result of public comments, the... subcontractors to adopt and enforce policies that ban texting while driving. The Executive Order does not include... Federal Motor Carrier Safety Administration (FMCSA) definitions of electronic device, texting, and...

  17. Smokeless tobacco marketing and sales practices in Appalachian Ohio following federal regulations

    NARCIS (Netherlands)

    Klein, E.G.; Ferketich, A.K.; Abdel-Rasoul, M.; Kwan, M.P.; Kenda, L.; Wewers, M.E.

    2012-01-01

    Introduction: Smokeless tobacco (ST) use is increasingly prevalent among poor and vulnerable groups, especially rural males. Access to tobacco products, as well as marketing messages, is associated with tobacco usage. In June 2010, the Tobacco Control Act (TCA) marked the beginning of federal

  18. 34 CFR Appendix A to Part 100 - Federal Financial Assistance to Which These Regulations Apply

    Science.gov (United States)

    2010-07-01

    ... OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION NONDISCRIMINATION UNDER PROGRAMS RECEIVING FEDERAL ASSISTANCE THROUGH THE DEPARTMENT OF EDUCATION EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 Pt.... Grants to agencies and organizations for Cuban refugees (22 U.S.C. 2601(b)(4)). 50. Grants and contracts...

  19. 75 FR 20825 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Part 211...

    Science.gov (United States)

    2010-04-21

    ..., or packing if the offeror chooses to propose such alternates. Propose Single Process Initiative (SPI... previously developed items. DoD uses the information to verify Government acceptance of an SPI process as a...) Single Process Initiative (SPI) processes in lieu of military or Federal specifications. The provision...

  20. 75 FR 50950 - Federal Speculative Position Limits for Referenced Energy Contracts and Associated Regulations

    Science.gov (United States)

    2010-08-18

    ... Commodity Exchange Act of 1936 (``Act'' or ``CEA'') by the recent enactment of the Dodd-Frank Wall Street... Commodity Exchange Act, 7 U.S.C. 1a(14). An exempt commodity is defined as a commodity that is neither an... From the Federal Register Online via the Government Publishing Office ] COMMODITY FUTURES TRADING...

  1. 78 FR 17668 - Federal Acquisition Regulation; Submission for OMB Review; Subcontracting Plans/Individual...

    Science.gov (United States)

    2013-03-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE..., the ISR collects subcontract awards for Historically Black Colleges and Universities and Minority... going down as the Government publishes rule that make the process less complex, more transparent,...

  2. Current regulations and state investment in the wind power projects

    Directory of Open Access Journals (Sweden)

    Danijela Simeunović

    2015-09-01

    Full Text Available It is the objective of this paper to present the path which the wind farm projects have undergone in Croatia from their introduction and expansion since the year 2007 up to the today's date when their development is temporarily stayed. The paper first describes the political and legal framework for renewable energy sources in Croatia, and specifically for wind power plants, as well as the current status of investment in building of wind farms in Croatia. The paper further analyses why the Croatian system of promotion of eligible producers has proven to attract investment, albeit unsustainable for a longer period of time, and which regulatory measures have later contributed to the suspension of wind farm investment in 2014. Legal and factual consequences of such suspension are discussed at the end of the paper, as well as some potential new business models for further exploitation of wind energy in Croatia.

  3. 76 FR 11985 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property

    Science.gov (United States)

    2011-03-04

    ... Acquisition Regulation Supplement; Reporting of Government-Furnished Property AGENCY: Defense Acquisition... expand reporting requirements for Government-furnished property to include items uniquely and non...

  4. Federal regulation of the pipeline industry: a summary review. [Effects on use of energy-conservation technology

    Energy Technology Data Exchange (ETDEWEB)

    Banks, W. F.

    1977-05-31

    The principal purposes of this report are: (1) identification of the jurisdiction areas of the Federal pipeline-regulating agencies, and (2) examination of the amenability of the regulatory system to the introduction of energy-conservative new technology into the pipeline industry. The history, scope, and agency structure of state and Federal regulation are recounted and some gaps, overlaps, and ambiguities are identified. The only significant inhibitory effects upon technological innovation are found to derive from the FPC and ICC limits upon profit, the 1941 Justice Department consent decree limiting dividends to shipper-owned pipelines, and the income tax rules governing recovery of investment credits and startup losses. Effects of these limits are explored by simulation studies using the Systems, Science and Software pipeline economic model (PEM). Two new concepts of regulation are proposed which would neutralize the inhibitory effect of the present regulatory system and would motivate pipeline operators to conserve energy: (1) use of a ''national equivalent value'' in the economic tradeoff analyses which justify entry of a technological innovation into the rate base (valuation), and (2) a ''valuation allowance'' which would reverse the presently often-existing situation and insure that the pipeline operator would realize a greater profit from saving energy than from wasting it.

  5. 78 FR 30898 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Rights in...

    Science.gov (United States)

    2013-05-23

    ... Technical Data and Computer Software--Small Business Innovation Research (SBIR) Program. In accordance with... Regulation Supplement; Rights in Technical Data and Computer Software AGENCY: Defense Acquisition Regulations... in Technical Data, and Subpart 227.72, Rights in Computer Software and Computer Software...

  6. 78 FR 6188 - Federal Acquisition Regulation; Free Trade Agreement-Colombia

    Science.gov (United States)

    2013-01-29

    ... Regulation; Free Trade Agreement--Colombia AGENCY: Department of Defense (DoD), General Services... Regulation (FAR) to implement the United States-Colombia Trade Promotion Agreement. This Trade Promotion... eligible products and services from Colombia. DATES: Effective Date: January 29, 2013. FOR...

  7. 76 FR 9714 - Defense Federal Acquisition Regulation Supplement; Passive Radio Frequency Identification (DFARS...

    Science.gov (United States)

    2011-02-22

    ...D Supply Chain Materiel Management Regulation, AP1.1.11: (i) Subclass of Class I--Packaged... supply, as defined in DoD 4140.1-R, DoD Supply Chain Materiel Management Regulation, AP1.1.11: (A... INFORMATION: I. Background This DFARS case was initiated at the request of the Office of Logistics...

  8. 77 FR 12913 - Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program

    Science.gov (United States)

    2012-03-02

    ... Regulation (FAR) to implement the Small Business Administration's regulations establishing the Women-Owned... in certain industries to economically disadvantaged women-owned small business (EDWOSB) concerns or... Appendix I of the Act amended the Small Business Act to provide for a procurement program for...

  9. 76 FR 38555 - Reorganization of Title 30, Code of Federal Regulations

    Science.gov (United States)

    2011-07-01

    ... that the Minerals Revenue Management Program (MRM) of the Bureau of Ocean Energy Management, Regulation... Bureau of Ocean Energy Management, Regulation and Enforcement 30 CFR Part 250 Office of Natural Resources Revenue 30 CFR Parts 1204, 1206, 1218, 1241, and 1290 RIN 1012-AA06 Reorganization of Title 30, Code...

  10. 77 FR 11367 - Defense Federal Acquisition Regulation Supplement; Extension of the Test Program for Negotiation...

    Science.gov (United States)

    2012-02-24

    ... Regulation Supplement; Extension of the Test Program for Negotiation of Comprehensive Small Business... Acquisition Regulation Supplement to extend the program period for the DoD Test Program for Negotiation of...). Section 866 amends the DoD Test Program for Negotiation of Comprehensive Small Business...

  11. 77 FR 2682 - Defense Federal Acquisition Regulation Supplement; DoD Voucher Processing

    Science.gov (United States)

    2012-01-19

    ... vouchers not selected for a pre-payment review will be considered to be provisionally approved and will be... after a pre-payment review. Interim vouchers not selected for a pre-payment review will be considered to... Regulation Supplement; DoD Voucher Processing AGENCY: Defense Acquisition Regulations System, Department...

  12. 77 FR 29982 - Federal Acquisition Regulation; Submission for OMB Review; Davis Bacon Act-Price Adjustment...

    Science.gov (United States)

    2012-05-21

    ... Regulation; Submission for OMB Review; Davis Bacon Act-Price Adjustment (Actual Method) AGENCY: Department of... previously approved information collection requirement concerning the Davis-Bacon Act price adjustment... Bacon Act-Price Adjustment (Actual Method), by any of the following methods: Regulations.gov :...

  13. 75 FR 53774 - Migratory Bird Hunting; Migratory Bird Hunting Regulations on Certain Federal Indian Reservations...

    Science.gov (United States)

    2010-09-01

    ... Wildlife Service 50 CFR Part 20 Migratory Bird Hunting; Migratory Bird Hunting Regulations on Certain...-1231-9BPP-L2] RIN 1018-AX06 Migratory Bird Hunting; Migratory Bird Hunting Regulations on Certain..., Interior. ACTION: Final rule. SUMMARY: This rule prescribes special early-season migratory bird...

  14. 75 FR 18034 - Defense Federal Acquisition Regulation Supplement; Research and Development Contract Type...

    Science.gov (United States)

    2010-04-08

    ... Regulation Supplement; Research and Development Contract Type Determination (DFARS Case 2006-D053) AGENCY... a major defense acquisition program (MDAP) to select the contract type for a development program... requires DoD to modify regulations regarding the determination of contract type for development programs...

  15. 75 FR 66686 - Defense Federal Acquisition Regulation Supplement; Balance of Payments Program Exemption for...

    Science.gov (United States)

    2010-10-29

    ... Regulation Supplement; Balance of Payments Program Exemption for Commercial Information Technology... Acquisition Regulation Supplement (DFARS) to implement the exemption from the Balance of Payments Program for... is amending the DFARS to implement in the clauses at 252.225- 7044, Balance of Payments...

  16. 76 FR 38050 - Defense Federal Acquisition Regulation Supplement; Management of Manufacturing Risk in Major...

    Science.gov (United States)

    2011-06-29

    ... Regulation Supplement; Management of Manufacturing Risk in Major Defense Acquisition Programs (DFARS Case... require the approval of the Office of Management and Budget under the Paperwork Reduction Act (44 U.S.C... Government procurement. Mary Overstreet, Editor, Defense Acquisition Regulations System. Therefore, 48...

  17. 75 FR 3236 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Science.gov (United States)

    2010-01-20

    ... and the provision at 52.230-5 include pertinent rules and regulations related to the Cost Accounting... Regulation; Submission for OMB Review; Cost Accounting Standards Administration AGENCIES: Department of...-0129). SUMMARY: Under the provisions of the Paperwork Reduction Act of 1995 (44 U.S.C. Chapter 35),...

  18. Notification: Hotline Complaint – Region 7 Compliance with Bid, Payment, and Performance Bond Requirements Outlined in Federal Acquisition Regulation (FAR) Part 28

    Science.gov (United States)

    June 1, 2012. In response to an anonymous hotline complaint, the OIG plans to conduct a review of Region 7’s compliance with bid, payment, and performance bond requirements outlined in Federal Acquisition Regulation (FAR) Part 28.

  19. UST System Compatibility with Petroleum-Biofuel Blends: A Brief Guide to the 2015 Federal UST Regulations for Owners and Operators of USTs Located on Tribal Lands

    Science.gov (United States)

    Review information for UST owners and operators on tribal lands with compatibility requirements in the 2015 federal UST regulation when storing gasoline blends containing greater than 10 percent ethanol or diesel blends containing greater than 20 percent.

  20. 78 FR 5451 - Federal Acquisition Regulation; Submission for OMB Review; Permits, Authorities, or Franchises

    Science.gov (United States)

    2013-01-25

    ... Regulation; Submission for OMB Review; Permits, Authorities, or Franchises AGENCIES: Department of Defense... previously approved information collection requirement concerning permits, authorities, or franchises for... 9000- 0053, Permits, Authorities, or Franchises, by any of the following methods:...

  1. 77 FR 67366 - Federal Acquisition Regulation; Information Collection; Quality Assurance Requirements

    Science.gov (United States)

    2012-11-09

    ... Regulation; Information Collection; Quality Assurance Requirements AGENCY: Department of Defense (DOD... information collection requirement concerning quality assurance requirements. Public comments are particularly... Information Collection 9000- 0077, Quality Assurance Requirements, by any of the following methods...

  2. 77 FR 69441 - Federal Acquisition Regulation; Information Collection; Cost Accounting Standards Administration

    Science.gov (United States)

    2012-11-19

    ... Regulation; Information Collection; Cost Accounting Standards Administration AGENCY: Department of Defense... approved information collection requirement concerning cost accounting standards administration. Public... comments identified by Information Collection 9000- 0129, Cost Accounting Standards Administration by...

  3. 77 FR 66464 - Federal Acquisition Regulation; Submission for OMB Review; Value Engineering Requirements

    Science.gov (United States)

    2012-11-05

    ... Regulation; Submission for OMB Review; Value Engineering Requirements AGENCIES: Department of Defense (DOD... approved information collection requirement concerning Value Engineering Requirements. A notice was...: Submit comments identified by Information Collection 9000- 0027, Value Engineering Requirements, by...

  4. 77 FR 43076 - Federal Acquisition Regulation; Information Collection; Value Engineering Requirements

    Science.gov (United States)

    2012-07-23

    ... Regulation; Information Collection; Value Engineering Requirements AGENCIES: Department of Defense (DOD... approved information collection requirement concerning Value Engineering Requirements. Public comments are...: Submit comments identified by Information Collection 9000- 0027, Value Engineering Requirements, by...

  5. 77 FR 50447 - Federal Management Regulation; Donation of Surplus Personal Property

    Science.gov (United States)

    2012-08-21

    ... Property AGENCY: Office of Governmentwide Policy, General Services Administration (GSA). ACTION: Proposed... Regulation (FMR) by changing its personal property policy. The proposed changes will (1) include the addition... surplus property those organizations whose membership comprises substantially of veterans, as authorized...

  6. 76 FR 52133 - Defense Federal Acquisition Regulation Supplement; Contractors Performing Private Security...

    Science.gov (United States)

    2011-08-19

    ... Acquisition Regulation Supplement; Contractors Performing Private Security Functions (DFARS Case 2011-D023..., equipping, and conduct of personnel performing private security functions. DATES: Effective Date: August 19.... 110-181, enacted October 28, 2008), section 862, entitled ``Contractors Performing Private...

  7. 77 FR 70780 - Federal Acquisition Regulation; Submission for OMB Review; Contractors Performing Private...

    Science.gov (United States)

    2012-11-27

    ... Regulation; Submission for OMB Review; Contractors Performing Private Security Functions Outside the United... 9000-0184, Contractors Performing Private Security Functions Outside the United States''. Follow the... ``Information Collection 9000-0184, Contractors Performing Private Security Functions Outside the United...

  8. 78 FR 66740 - Federal Acquisition Regulation; Submission for OMB Review; Patents

    Science.gov (United States)

    2013-11-06

    ... Regulation; Submission for OMB Review; Patents AGENCIES: Department of Defense (DOD), General Services... requirement concerning patents. DATES: Submit comments on or before December 6, 2013. ADDRESSES: Submit comments identified by Information Collection 9000- 0096, Patents, by any of the following...

  9. 78 FR 54250 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Science.gov (United States)

    2013-09-03

    ... Regulation; Information Collection; American Recovery and Reinvestment Act-Reporting Requirements--Quarterly... Information Collection 9000- 0169, American Recovery and Reinvestment Act--Quarterly Reporting for Prime... Comment'' that corresponds with ``Information Collection 9000-0169, American Recovery and Reinvestment...

  10. 76 FR 9680 - Defense Federal Acquisition Regulation Supplement; Repeal of the Small Business Competitiveness...

    Science.gov (United States)

    2011-02-22

    ... Regulation Supplement; Repeal of the Small Business Competitiveness Demonstration Program (DFARS Case 2011... Competitiveness Demonstration Program. DATES: Effective Date: February 22, 2011. FOR FURTHER INFORMATION CONTACT....S.C. 644 note). The repeal of the Small Business Competitiveness Demonstration Program...

  11. 77 FR 43077 - Federal Acquisition Regulation; Information Collection; Economic Purchase Quantity-Supplies

    Science.gov (United States)

    2012-07-23

    ... Regulation; Information Collection; Economic Purchase Quantity--Supplies AGENCIES: Department of Defense (DOD... approved information collection requirement concerning Economic Purchase Quantity--Supplies. Public...: Submit comments identified by Information Collection 9000- 0082, Economic Purchase Quantity--Supplies, by...

  12. 77 FR 51783 - Federal Acquisition Regulation; Information Collection; Contractors' Purchasing Systems Reviews

    Science.gov (United States)

    2012-08-27

    ... Regulation; Information Collection; Contractors' Purchasing Systems Reviews AGENCY: Department of Defense... previously approved information collection requirement concerning contractors' purchasing systems reviews...: Submit comments identified by Information Collection 9000- 0132, Contractors' Purchasing Systems Reviews...

  13. 76 FR 78126 - Disclosure Requirements for Depository Institutions Lacking Federal Deposit Insurance (Regulation I)

    Science.gov (United States)

    2011-12-16

    ... INFORMATION CONTACT: Krista Ayoub or Jane Gao, Office of Regulations, at (202) 435-7700. SUPPLEMENTARY... accepts deposits or opens accounts (excluding automated teller machines or point of sale terminals), and...

  14. 75 FR 48276 - Defense Federal Acquisition Regulation Supplement; Management of Unpriced Change Orders

    Science.gov (United States)

    2010-08-10

    ... Acquisition Regulation Supplement; Management of Unpriced Change Orders AGENCY: Defense Acquisition... management and oversight of unpriced change orders consistent with those that apply to other undefinitized.... * * * * * (c) Consolidated UCA Management Reports shall include information about all change orders that are...

  15. 77 FR 20012 - Federal Acquisition Regulation; Information Collection; Corporate Aircraft Costs

    Science.gov (United States)

    2012-04-03

    ...., destination, passenger name, purpose of trip, etc.). This information, as required by FAR 31.205-46, Travel... Regulation; Information Collection; Corporate Aircraft Costs AGENCY: Department of Defense (DOD),...

  16. 76 FR 20351 - Federal Acquisition Regulation; Information Collection; Architect-Engineer Qualifications (SF 330)

    Science.gov (United States)

    2011-04-12

    ... Regulation; Information Collection; Architect-Engineer Qualifications (SF 330) AGENCIES: Department of... the Architect-Engineer Qualifications form (SF 330). Public comments are particularly invited on..., Architect-Engineer Qualifications (SF 330), in all correspondence. Dated: April 4, 2011. Millisa...

  17. 76 FR 81942 - Federal Acquisition Regulation; Information Collection; Progress Payments (SF-1443)

    Science.gov (United States)

    2011-12-29

    ... Regulation; Information Collection; Progress Payments (SF-1443) AGENCIES: Department of Defense (DOD... ``Progress Payments,'' contractors are required to request progress payments on Standard Form (SF) 1443... information, reasonably requested by the Contracting Officer. The contractual requirement for submission of...

  18. 77 FR 19287 - Federal Acquisition Regulation; Submission for OMB Review; Progress Payments (SF-1443)

    Science.gov (United States)

    2012-03-30

    ... Register at 76 FR 81942, on December 29, 2011. No comments were received. Public comments are particularly... Regulation; Submission for OMB Review; Progress Payments (SF-1443) AGENCY: Department of Defense...

  19. 77 FR 66466 - Federal Acquisition Regulation; Submission for OMB Review; Notice of Radioactive Materials

    Science.gov (United States)

    2012-11-05

    ... Regulation; Submission for OMB Review; Notice of Radioactive Materials AGENCY: Department of Defense (DOD... approved information collection requirement concerning Notice of Radioactive Materials. A notice was...: Submit comments identified by Information Collection 9000- 0107, Notice of Radioactive Materials, by...

  20. 77 FR 45612 - Federal Acquisition Regulation; Information Collection; Notice of Radioactive Materials

    Science.gov (United States)

    2012-08-01

    ... Regulation; Information Collection; Notice of Radioactive Materials AGENCY: Department of Defense (DOD... approved information collection requirement concerning Notice of Radioactive Materials. Public comments are... comments identified by Information Collection 9000- 0107, Notice of Radioactive Materials, by any of...

  1. 78 FR 23935 - Federal Acquisition Regulation; Information Collection; Contractor Use of Interagency Fleet...

    Science.gov (United States)

    2013-04-23

    ... Regulation; Information Collection; Contractor Use of Interagency Fleet Management System Vehicles AGENCY... previously approved information collection requirement concerning contractor use of interagency fleet... Collection 9000- 0032, Contractor Use of Interagency Fleet Management System Vehicles, by any of...

  2. 77 FR 3636 - Federal Acquisition Regulation; Brand-Name Specifications; Correction

    Science.gov (United States)

    2012-01-25

    ... Acquisition Regulation; Brand-Name Specifications; Correction AGENCY: Department of Defense (DoD), General... Management and Budget memoranda on brand-name specifications, FAR Case 2005-037, Brand-Name...

  3. 77 FR 43077 - Federal Acquisition Regulation; Information Collection; North Carolina Sales Tax Certification

    Science.gov (United States)

    2012-07-23

    ... Regulation; Information Collection; North Carolina Sales Tax Certification AGENCY: Department of Defense (DOD... approved information collection requirement concerning North Carolina sales tax certification. Public...: Submit comments identified by Information Collection 9000- 0059, North Carolina Sales Tax...

  4. 77 FR 73659 - Federal Acquisition Regulation; Information Collection; Schedules for Construction Contracts

    Science.gov (United States)

    2012-12-11

    ... Regulation; Information Collection; Schedules for Construction Contracts AGENCIES: Department of Defense (DOD... previously approved information collection requirement concerning schedules for construction contracts...: Submit comments identified by Information Collection 9000- 0058, Schedules for Construction Contracts...

  5. 78 FR 22841 - Defense Federal Acquisition Regulation Supplement: Encouragement of Science, Technology...

    Science.gov (United States)

    2013-04-17

    ... Regulation Supplement: Encouragement of Science, Technology, Engineering, and Mathematics (STEM) Programs... contractors to develop science, technology, engineering, and mathematics (STEM) programs. FOR FURTHER... 2012, which requires DoD to encourage contractors to develop science, technology, engineering,...

  6. 76 FR 37353 - Federal Acquisition Regulation; Submission for OMB Review; Contractor Business Ethics Compliance...

    Science.gov (United States)

    2011-06-27

    ... Regulation; Submission for OMB Review; Contractor Business Ethics Compliance Program and Disclosure... requirement concerning contractor business ethics compliance program and disclosure requirements. Public... Information Collection 9000- 0164, Contractor Business Ethics Compliance Program and Disclosure...

  7. 76 FR 60837 - Federal Acquisition Regulation; Information Collection; Contractor Business Ethics Compliance...

    Science.gov (United States)

    2011-09-30

    ... Regulation; Information Collection; Contractor Business Ethics Compliance Program and Disclosure Requirements... concerning contractor business ethics compliance program and disclosure requirements. Public comments are... Collection 9000- 0164, Contractor Business Ethics Compliance Program and Disclosure Requirements, by any...

  8. Analysis of interest group influence on federal school meals regulations 1992 to 1996.

    Science.gov (United States)

    Hobbs, Suzanne Havala; Ricketts, Thomas C; Dodds, Janice M; Milio, Nancy

    2004-01-01

    Regulatory changes proposed by the US Department of Agriculture in 1994 promised to bring progressive changes to school meals. However, lobbying by interest groups resulted in substantial changes to the final rule. This analysis retrospectively examines the federal school meals policy-making process during 1992 to 1996. Key questions address why the policy changed and what the role of interest groups was in affecting the shape, pace, and direction of the policy. The study provides suggestions for using the experiences of 1992 to 1996 to guide future advocacy efforts and for adapting the approach for application to other food and nutrition policies.

  9. Television food marketing to children revisited: the Federal Trade Commission has the constitutional and statutory authority to regulate.

    Science.gov (United States)

    Pomeranz, Jennifer L

    2010-01-01

    The evidence reveals that young children are targeted by food and beverage advertisers but are unable to comprehend the commercial context and persuasive intent of marketing. Although the First Amendment protects commercial speech, it does not protect deceptive and misleading speech for profit. Marketing directed at children may fall into this category of unprotected speech. Further, children do not have the same First Amendment right to receive speech as adults. For the first time since the Federal Trade Commission's original attempt to regulate marketing to children in the 1970s (termed KidVid), the political, scientific, and legal climate coalesce to make the time well-suited to reevaluate the FTC's authority for action. This paper analyzes the constitutional authority for the FTC to regulate television food marketing directed at children as deceptive in light of the most robust public health evidence on the subject.

  10. REACTIVE CURRENT OF AN INDUCTION ELECTRIC DRIVES WITH THYRISTOR VOLTAGE REGULATOR

    Directory of Open Access Journals (Sweden)

    J.V. Kovalova

    2014-12-01

    Full Text Available A model for a separation of reactive constituent from current of idling of an induction motor at its feed from a thyristor voltage regulator in the dependences on the control angle of thyristors is developed. As a result of modeling, dependence of relative reactive current which is approximated by formula for calculation of effective current of reactive constituent of nonsinusoidal current is obtained.

  11. Self-regulation of the reconnecting current layer in relativistic pair plasma reconnection

    CERN Document Server

    Zenitani, S

    2008-01-01

    We investigate properties of the reconnecting current layer in relativistic pair plasma reconnection. We found that the current layer self-regulates its thickness when the current layer runs out current carriers and so relativistic reconnection retains a fast reconnection rate. Constructing a steady state Sweet-Parker model, we discuss conditions for the current sheet expansion. Based on the energy argument we conclude that the incompressible assumption is invalid in relativistic Sweet-Parker reconnection. The guide field cases are more incompressible than the anti-parallel cases, and we find a more significant current sheet expansion.

  12. Reconciliation of the cloud computing model with US federal electronic health record regulations.

    Science.gov (United States)

    Schweitzer, Eugene J

    2012-01-01

    Cloud computing refers to subscription-based, fee-for-service utilization of computer hardware and software over the Internet. The model is gaining acceptance for business information technology (IT) applications because it allows capacity and functionality to increase on the fly without major investment in infrastructure, personnel or licensing fees. Large IT investments can be converted to a series of smaller operating expenses. Cloud architectures could potentially be superior to traditional electronic health record (EHR) designs in terms of economy, efficiency and utility. A central issue for EHR developers in the US is that these systems are constrained by federal regulatory legislation and oversight. These laws focus on security and privacy, which are well-recognized challenges for cloud computing systems in general. EHRs built with the cloud computing model can achieve acceptable privacy and security through business associate contracts with cloud providers that specify compliance requirements, performance metrics and liability sharing.

  13. 78 FR 17404 - Federal Acquisition Regulation; Submission for OMB Review; Extraordinary Contractual Action Requests

    Science.gov (United States)

    2013-03-21

    ... change to http://www.regulations.gov , including any personal and/or business confidential information... agency did not accurately estimate the public burden challenging that the agency's methodology for... public. This is evidenced, as the respondent notes, in FAR Case 2007-006 where an adjustment was made...

  14. 78 FR 38341 - Federal Acquisition Regulation; Information Collection; Preaward Survey Forms (Standard Forms...

    Science.gov (United States)

    2013-06-26

    ... change to http://www.regulations.gov , including any personal and/or business confidential information...) necessary to determine contractor responsibility in each case. B. Annual Reporting Burden There are no... burden of this collection of information is accurate, and based on valid assumptions and methodology...

  15. 77 FR 35661 - Federal Acquisition Regulation; Information Collection; Evaluation of Export Offers

    Science.gov (United States)

    2012-06-14

    ... Regulation; Information Collection; Evaluation of Export Offers AGENCIES: Department of Defense (DOD... include your name, company name (if any), and ``Information Collection 9000-0057, Evaluation of Export... approved information collection requirement concerning the provision at FAR 52.247-51,...

  16. 78 FR 37692 - Federal Acquisition Regulation; Contracting With Women-Owned Small Business Concerns

    Science.gov (United States)

    2013-06-21

    ... Regulation; Contracting With Women-Owned Small Business Concerns AGENCY: Department of Defense (DoD), General... small business concerns and to women-owned small business concerns eligible under the Women-owned Small... ] Women-owned Small Business Concerns, which is the statutory authority for SBA's......

  17. 78 FR 18877 - Defense Federal Acquisition Regulation Supplement: New Free Trade Agreement With Colombia (DFARS...

    Science.gov (United States)

    2013-03-28

    ... Regulation Supplement: New Free Trade Agreement With Colombia (DFARS Case 2012-D032) AGENCY: Defense... (DFARS) to implement the United States-Colombia Trade Promotion Agreement. This Trade Promotion Agreement is a free trade agreement that provides for mutually non-discriminatory treatment of eligible...

  18. 77 FR 69723 - Federal Acquisition Regulation; Free Trade Agreement-Panama

    Science.gov (United States)

    2012-11-20

    ... Regulation; Free Trade Agreement--Panama AGENCIES: Department of Defense (DoD), General Services... implement the United States-- Panama Trade Promotion Agreement. This Trade Promotion Agreement is a free... Promotion Agreement is designated in the FAR as the Panama Free Trade Agreement (FTA). This FTA provides for...

  19. 78 FR 18876 - Defense Federal Acquisition Regulation Supplement: United States-Korea Free Trade Agreement...

    Science.gov (United States)

    2013-03-28

    ... Regulation Supplement: United States- Korea Free Trade Agreement (DFARS Case 2012-D025) AGENCY: Defense... (DFARS) to implement the United States-Korea Free Trade Agreement. The Republic of Korea is already party..., 2012, to implement the United States-Korea Free Trade Agreement (see the United States-Korea Free Trade...

  20. 77 FR 56739 - Federal Acquisition Regulation; United States-Korea Free Trade Agreement

    Science.gov (United States)

    2012-09-13

    ... States-Korea Free Trade Agreement AGENCY: Department of Defense (DoD), General Services Administration... Regulation (FAR) to implement the United States-Korea Free Trade Agreement. The Republic of Korea is already... the Republic of Korea to the definition of ``Free Trade Agreement country'' in multiple locations in...

  1. 77 FR 30355 - Defense Federal Acquisition Regulation Supplement: United States-Korea Free Trade Agreement...

    Science.gov (United States)

    2012-05-22

    ... Regulation Supplement: United States- Korea Free Trade Agreement (DFARS Case 2012-D025) AGENCY: Defense... United States-Korea Free Trade Agreement. The Republic of Korea is already party to the World Trade... provisions and clauses in DFARS part 252 to implement the United States-Korea Free Trade Agreement (see the...

  2. 77 FR 43081 - Federal Acquisition Regulation; Information Collection; Buy American Act-Free Trade Agreements...

    Science.gov (United States)

    2012-07-23

    ... Regulation; Information Collection; Buy American Act--Free Trade Agreements--Israeli Trade Act Certificate... previously approved information collection requirement concerning the Buy American Act--Free Trade Agreements..., Buy American Act--Free Trade Agreements--Israeli Trade Act Certificate, by any of the following...

  3. 78 FR 72620 - Federal Acquisition Regulation; Higher-Level Contract Quality Requirements

    Science.gov (United States)

    2013-12-03

    ... posted without change to http://www.regulations.gov , including any personal and/or business confidential... counterfeit electronic parts. However, because of the globalization of the marketplace, the problem of... and industry. Globalization in the marketplace increased the risk of counterfeit items in...

  4. 75 FR 8362 - Federal Acquisition Regulation; Submission for OMB Review; Patents

    Science.gov (United States)

    2010-02-24

    ... Regulation; Submission for OMB Review; Patents AGENCY: Department of Defense (DOD), General Services... approved information collection requirement concerning patents. A request for public ] comments was..., GSA (202) 501-3775 or e-mail ernest.woodson@gsa.gov . SUPPLEMENTARY INFORMATION: A. Purpose The...

  5. 78 FR 23194 - Federal Acquisition Regulation; Commercial and Government Entity Code

    Science.gov (United States)

    2013-04-18

    ... registration is not required, a CAGE code will be requested and obtained from the Defense Logistics Agency, Logistics Information Service. A CAGE code is not required when a condition described at FAR 4.605(c)(2... assess all costs and benefits of available regulatory alternatives and, if regulation is necessary, to...

  6. 78 FR 13544 - Defense Federal Acquisition Regulation Supplement: Acquisition of Tents and Other Temporary...

    Science.gov (United States)

    2013-02-28

    ... Acquisition Regulation Supplement: Acquisition of Tents and Other Temporary Structures (DFARS Case 2012-D015... the National Defense Authorization Act for Fiscal Year 2012 that address the acquisition of tents and... contracts that provide the best value, when acquiring tents and other temporary structures, regardless...

  7. 77 FR 38734 - Defense Federal Acquisition Regulation Supplement; Acquisition of Tents and Other Temporary...

    Science.gov (United States)

    2012-06-29

    ... Regulation Supplement; Acquisition of Tents and Other Temporary Structures (DFARS Case 2012-D015) AGENCY... 2012 that address the acquisition of tents and other temporary structures. DATES: Effective date: June... the best value, when acquiring tents and other temporary structures, regardless of whether...

  8. 77 FR 75766 - Federal Acquisition Regulation; Nondisplacement of Qualified Workers Under Service Contracts

    Science.gov (United States)

    2012-12-21

    ... DOL implementing regulations. For clarity, a definition of ``service employee'' was added, and the... the SCA. The definition of ``service employee'' at 41 U.S.C. 6701(3) provides, in part, that it ``does... construction equipment.'' The definition of ``service employee'' addresses this concept. Therefore, FAR...

  9. 78 FR 54650 - Federal Acquisition Regulation; Information Collection American Recovery and Reinvestment Act...

    Science.gov (United States)

    2013-09-05

    ... Regulation; Information Collection American Recovery and Reinvestment Act-Reporting Requirements--One-Time... comments identified by Information Collection 9000- 0167, American Recovery and Reinvestment Act-Reporting.... Instructions: Please submit comments only and cite Information Collection 9000-0167, American Recovery...

  10. 78 FR 54648 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Science.gov (United States)

    2013-09-05

    ... Regulation; Information Collection; American Recovery and Reinvestment Act--Reporting Requirements--One-Time... identified by Information Collection 9000- 0168, American Recovery and Reinvestment Act--Reporting..., company name (if any), and ``Information Collection 9000-0168, American Recovery and Reinvestment...

  11. 78 FR 38340 - Federal Acquisition Regulation; Submission for OMB Review; Right of First Refusal of Employment

    Science.gov (United States)

    2013-06-26

    ... Regulation; Submission for OMB Review; Right of First Refusal of Employment AGENCY: Department of Defense...: Submit comments identified by Information Collection 9000- 0114, Right of First Refusal of Employment, by... corresponds with ``Information Collection 9000-0114, Right of First Refusal of Employment''. Follow...

  12. 78 FR 17670 - Federal Acquisition Regulation; Information Collection; Right of First Refusal of Employment

    Science.gov (United States)

    2013-03-22

    ... Regulation; Information Collection; Right of First Refusal of Employment AGENCY: Department of Defense (DoD... comments identified by Information Collection 9000- 0114, Right of First Refusal of Employment, by any of... corresponds with ``Information Collection 9000-0114, Right of First Refusal of Employment''. Follow...

  13. 75 FR 4565 - Federal Acquisition Regulation; Submission for OMB Review; Right of First Refusal of Employment

    Science.gov (United States)

    2010-01-28

    ... Regulation; Submission for OMB Review; Right of First Refusal of Employment AGENCIES: Department of Defense....sakalos@gsa.gov . SUPPLEMENTARY INFORMATION: A. Purpose Right of First Refusal of Employment is a..., DC 20405, telephone (202) 501-4755. Please cite OMB Control No. 9000-0114, Right of First Refusal...

  14. 77 FR 38736 - Defense Federal Acquisition Regulation Supplement: New Qualifying Country-Czech Republic (DFARS...

    Science.gov (United States)

    2012-06-29

    ... enterprises of the other country to the extent mutually beneficial and consistent with national laws, regulations, policies, and international obligations. The agreement does not cover construction or... meaning of the basic DoD policy on contracting with qualifying country sources. Accordingly, the change...

  15. 75 FR 71560 - Defense Federal Acquisition Regulation Supplement; Cost and Software Data Reporting System (DFARS...

    Science.gov (United States)

    2010-11-24

    ... is provided for contractors with accounting software that does not accommodate the additional data... Acquisition Regulation Supplement; Cost and Software Data Reporting System (DFARS Case 2008-D027) AGENCY... Cost and Software Data Reporting system requirements for Major Defense Acquisition Programs and...

  16. 77 FR 30365 - Defense Federal Acquisition Regulation Supplement: Report on Waiver of Prohibition on Acquisition...

    Science.gov (United States)

    2012-05-22

    ... Regulation Supplement: Report on Waiver of Prohibition on Acquisition From Communist Chinese Military... prohibition on acquisition of United States Munitions List items from Communist Chinese military companies... Chinese military companies. The prior requirement was for a report within 30 days after the date of the...

  17. 75 FR 75549 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2010-12-03

    ... Acquisition Regulation Supplement; Business Systems-- Definition and Administration (DFARS Case 2009-D038...D published a proposed rule for Business Systems--Definition and Administration (DFARS Case 2009... contractor business systems, DoD is considering a rule to clarify the definition and administration...

  18. 75 FR 8272 - Defense Federal Acquisition Regulation Supplement; Acquisition Strategies To Ensure Competition...

    Science.gov (United States)

    2010-02-24

    ... Regulation Supplement; Acquisition Strategies To Ensure Competition Throughout the Life Cycle of Major... Reform Act of 2009, section 202, Acquisition Strategies to Ensure Competition throughout the Lifecycle of... requirements. Section 202 directs the Secretary of Defense (SECDEF) to ensure that the acquisition strategy...

  19. 76 FR 35219 - Federal Acquisition Regulation; Information Collection; Payment by Electronic Fund Transfer

    Science.gov (United States)

    2011-06-16

    ... Regulation; Information Collection; Payment by Electronic Fund Transfer AGENCY: Department of Defense (DOD... transfer. Public comments are particularly invited on: Whether this collection of information is necessary... those who are to respond, through the use of appropriate technological collection techniques or...

  20. 75 FR 73997 - Defense Federal Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010...

    Science.gov (United States)

    2010-11-30

    ..., entitled ``Efforts to Prevent Sexual Assault/Harassment Involving DoD Contractors During Contingency...; Definition of Sexual Assault (DFARS Case 2010-D023) AGENCY: Defense Acquisition Regulations System... are aware of the DoD definition of ``sexual assault'' as defined in DoD Directive 6495.01,...

  1. 76 FR 38051 - Defense Federal Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010...

    Science.gov (United States)

    2011-06-29

    .... Background DoD Inspector General audit D-2010-052, entitled ``Efforts to Prevent Sexual Assault/Harassment... Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010-D023) AGENCY: Defense Acquisition... accompanying U.S. Armed Forces are made aware of the DoD definition of sexual assault as defined in...

  2. 77 FR 13328 - Federal Acquisition Regulation; Information Collection; Davis Bacon Act-Price Adjustment (Actual...

    Science.gov (United States)

    2012-03-06

    ... Regulation; Information Collection; Davis Bacon Act--Price Adjustment (Actual Method) AGENCY: Department of... previously approved information collection requirement concerning the Davis-Bacon Act price adjustment... comments identified by Information Collection 9000- 0154, Davis Bacon Act--Price Adjustment (Actual...

  3. 75 FR 13764 - Federal Acquisition Regulation; Information Collection; Rights in Data and Copyrights

    Science.gov (United States)

    2010-03-23

    ... only when the very nature of the contractor's work is comprised of limited rights data or restricted... Regulation; Information Collection; Rights in Data and Copyrights AGENCIES: Department of Defense (DOD... extension of a previously approved information collection requirement concerning rights in data and...

  4. 78 FR 5452 - Federal Acquisition Regulation; Submission for OMB Review; Qualification Requirements

    Science.gov (United States)

    2013-01-25

    ... award of a contract. Under the qualification requirements, an end item, or a component thereof, may be... offeror before award of a contract. Under the qualification requirements, an end item, or a component... Regulation; Submission for OMB Review; Qualification Requirements AGENCIES: Department of Defense...

  5. 76 FR 78858 - Defense Federal Acquisition Regulation Supplement; Utilization of Domestic Photovoltaic Devices...

    Science.gov (United States)

    2011-12-20

    ... adverse effects on the U.S. photovoltaic industry, which this statute was designed to protect. However... Acquisition Regulation Supplement; Utilization of Domestic Photovoltaic Devices (DFARS Case 2011-D046) AGENCY... 2011. The section provides that photovoltaic devices to be utilized in performance of any covered...

  6. 75 FR 60266 - Federal Acquisition Regulation; Buy American Exemption for Commercial Information Technology...

    Science.gov (United States)

    2010-09-29

    ... Regulation; Buy American Exemption for Commercial Information Technology--Construction Material AGENCIES... Act for acquisition of information technology that is a commercial item. DATES: Effective Date... the Buy American Act for acquisition of information technology that is a commercial item. This...

  7. 76 FR 58155 - Defense Federal Acquisition Regulation Supplement; Construction and Architect-Engineer Services...

    Science.gov (United States)

    2011-09-20

    ... Regulation Supplement; Construction and Architect-Engineer Services Performance Evaluation (DFARS Case 2010... construction and architect-engineer services. DATES: Effective Date: September 20, 2011. FOR FURTHER... construction and Architect- Engineer services. On April 19, 2011, DoD published a proposed rule in the...

  8. 76 FR 21851 - Defense Federal Acquisition Regulation Supplement; Construction and Architect-Engineer Services...

    Science.gov (United States)

    2011-04-19

    ... Regulation Supplement; Construction and Architect-Engineer Services Performance Evaluation (DFARS Case 2010... construction and architect-engineer services. DATES: Comments on the proposed rule should be submitted in... requirement to use DoD-unique forms to document contractor past performance for construction and...

  9. 75 FR 65437 - Defense Federal Acquisition Regulation Supplement; Defense Cargo Riding Gang Members (DFARS Case...

    Science.gov (United States)

    2010-10-25

    ... Acquisition Regulation Supplement; Defense Cargo Riding Gang Members (DFARS Case 2007-D002) AGENCY: Defense... 3504 addresses requirements that apply to riding gang members and DoD- exempted individuals who perform.... 109-364). Section 3504 addresses requirements that apply to riding gang members and...

  10. 78 FR 73450 - Defense Federal Acquisition Regulation Supplement: Preparation of Letter of Offer and Acceptance...

    Science.gov (United States)

    2013-12-06

    ... Regulation Supplement: Preparation of Letter of Offer and Acceptance (DFARS Case 2012-D048) AGENCY: Defense... of ] the letter of offer and acceptance for a foreign military sales program that will require an... activity in preparing the letter of offer and acceptance for a foreign military sales program that...

  11. 78 FR 28793 - Defense Federal Acquisition Regulation Supplement: Preparation of Letter of Offer and Acceptance...

    Science.gov (United States)

    2013-05-16

    ... Regulation Supplement: Preparation of Letter of Offer and Acceptance (DFARS Case 2012-D048) AGENCY: Defense... officer role in assisting the DoD implementing agency in preparation of the letter of offer and acceptance... to assist the DoD implementing activity in preparing the letter of offer and acceptance for a...

  12. 77 FR 52252 - Defense Federal Acquisition Regulation Supplement: Inflation Adjustment of Threshold for...

    Science.gov (United States)

    2012-08-29

    ...-related dollar thresholds subject to inflation adjustment in accordance with the requirements of 41 U.S.C... Regulation Supplement: Inflation Adjustment of Threshold for Acquisition of Right-Hand Drive Passenger Sedans... Authorization Act for Fiscal Year 2012 that requires adjustment of the statutory dollar limitation on...

  13. 75 FR 34942 - Defense Federal Acquisition Regulation Supplement; Multiyear Contract Authority for Electricity...

    Science.gov (United States)

    2010-06-21

    ... Regulation Supplement; Multiyear Contract Authority for Electricity From Renewable Energy Sources (DFARS Case... enter into a contract for a period not to exceed 10 years for the purchase of electricity from sources... electricity from sources of renewable energy, as that term is defined in section 203(b)(2) of the Energy...

  14. 76 FR 14587 - Defense Federal Acquisition Regulation Supplement; Multiyear Contract Authority for Electricity...

    Science.gov (United States)

    2011-03-17

    ... Regulation Supplement; Multiyear Contract Authority for Electricity From Renewable Energy Sources (DFARS Case... Defense to enter into a contract for a period not to exceed 10 years for the purchase of electricity from... prepared by DoD, that-- (1) The proposed purchase of electricity under such contract is cost effective; and...

  15. 76 FR 55389 - Federal Acquisition Regulation; Submission for OMB Review; Architect-Engineer Qualifications (SF...

    Science.gov (United States)

    2011-09-07

    ... Register at 76 FR 20351, on April 12, 2011. One comment was received. General Comment A respondent... Regulation; Submission for OMB Review; Architect-Engineer Qualifications (SF 330) AGENCIES: Department of... Architect-Engineer Qualifications form (SF 330). Public comments are particularly invited on: Whether...

  16. 75 FR 33237 - Defense Federal Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS...

    Science.gov (United States)

    2010-06-11

    ...; Contractor Insurance/Pension Review (DFARS Case 2009-D025) AGENCY: Defense Acquisition Regulations System... and relocate the requirements for conducting a Contractor Insurance/Pension Review from Procedures... requirements for Contractor Insurance/Pension Review (CIPR) from DFARS 242.7302 to Procedures, Guidance, and...

  17. 78 FR 48397 - Defense Federal Acquisition Regulation Supplement: Clauses With Alternates-Transportation (DFARS...

    Science.gov (United States)

    2013-08-08

    .... Manuel Quinones, Editor, Defense Acquisition Regulations System. Therefore, 48 CRF parts 212, 216, 247..., subassemblies, accessories, and equipment; machine tools; material; equipment; stores of all kinds; end items...; equipment; stores of all kinds; end items; construction materials; and components of the foregoing. (7)...

  18. 78 FR 69086 - Federal Acquisition Regulation; Submission for OMB Review; Preaward Survey Forms (Standard Forms...

    Science.gov (United States)

    2013-11-18

    ... will be posted without change to http://www.regulations.gov , including any personal and/or business... Forms 1403, 1404, 1405, 1406, 1407, and 1408 in detail commensurate with the dollar value and complexity... Government that bears the burden of the effort. The Government's work in conducting a preaward survey is not...

  19. 75 FR 70263 - Federal Acquisition Regulation; Submission for OMB Review; Reporting Purchases From Sources...

    Science.gov (United States)

    2010-11-17

    ... Regulation; Submission for OMB Review; Reporting Purchases From Sources Outside the United States AGENCY... reporting purchases from sources outside the United States. Public comments are particularly invited on... technological collection techniques or other forms of information technology. DATES: Submit comments on...

  20. 78 FR 53217 - Migratory Bird Hunting; Migratory Bird Hunting Regulations on Certain Federal Indian Reservations...

    Science.gov (United States)

    2013-08-28

    ... goose flocks were 5.0 times more likely to fly within gun range ( http://www.regulations.gov at Docket... carcass tags are required prior to hunting. Sora and Virginia Rails: All Areas Season Dates: Begin September 1 and end November 24, 2013. Daily Bag Limit: 25 sora and Virginia rails, singly or in...

  1. 76 FR 37353 - Federal Acquisition Regulation; Information Collection; Certification of Independent Price...

    Science.gov (United States)

    2011-06-27

    ... valid assumptions and methodology; ways to enhance the quality, utility, and clarity of the information... ``Information Collection 9000-0018'' under the heading ``Enter Keyword or ID'' and selecting ``Search''. Select... Regulation; Information Collection; Certification of Independent Price Determination and Parent Company...

  2. 78 FR 13675 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Science.gov (United States)

    2013-02-28

    ... accounting practice change, the total potential impact of the change on contracts containing a CAS provision... Regulation; Submission for OMB Review; Cost Accounting Standards Administration AGENCY: Department of Defense...: Under the provisions of the Paperwork Reduction Act, the Regulatory Secretariat will be submitting...

  3. 77 FR 19126 - Defense Federal Acquisition Regulation Supplement: New Threshold for Peer Reviews of...

    Science.gov (United States)

    2012-03-30

    ... Regulation Supplement: New Threshold for Peer Reviews of Noncompetitive Contracts (DFARS Case 2012-D018... modify the threshold for noncompetitive contract peer reviews. DATES: Effective Date: April 30, 2012. FOR.... Background This final rule reduces the threshold for DoD peer reviews of noncompetitive contracts from...

  4. 77 FR 10461 - Federal Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor Excise...

    Science.gov (United States)

    2012-02-22

    ....regulations.gov , including any personal and/or business confidential information provided. FOR FURTHER... effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance of quantifying both costs..., Regulatory Planning and Review, dated September 30, 1993. This rule is not a major rule under 5 U.S.C....

  5. 78 FR 60169 - Federal Acquisition Regulation; Pilot Program for Enhancement of Contractor Employee...

    Science.gov (United States)

    2013-09-30

    ...://www.regulations.gov , including any personal and/or business confidential information provided. FOR... equity). E.O. 13563 emphasizes the importance of quantifying both costs and benefits, of reducing costs..., therefore, was subject to review under section 6(b) of E.O. 12866, Regulatory Planning and Review,...

  6. 77 FR 27547 - Federal Acquisition Regulation; Prohibition on Contracting With Inverted Domestic Corporations

    Science.gov (United States)

    2012-05-10

    ... be posted without change to http://www.regulations.gov , including any personal and/or business..., public health and safety effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance... section 6(b) of E.O. 12866, Regulatory Planning and Review, dated September 30, 1993. This rule is not...

  7. 76 FR 42127 - Federal Acquisition Regulation; Submission for OMB Review; Place of Performance

    Science.gov (United States)

    2011-07-18

    ..., company name (if any), and ``Information Collection 9000-0047 Place of Performance'' on your attached... place of performance and owner of plant or facility, if other than the prospective contractor, is a... Regulation; Submission for OMB Review; Place of Performance AGENCY: Department of Defense (DOD), General...

  8. 78 FR 13604 - Defense Federal Acquisition Regulation Supplement: Encouragement of Science, Technology...

    Science.gov (United States)

    2013-02-28

    ... Regulation Supplement: Encouragement of Science, Technology, Engineering, and Mathematics (STEM) Programs..., which requires DoD to take steps to encourage contractors to develop science, technology, engineering... (FY12), which requires DoD to encourage contractors to develop science, technology, engineering,...

  9. 78 FR 45198 - Federal Acquisition Regulation; Submission for OMB Review; Anti-Kickback Procedures

    Science.gov (United States)

    2013-07-26

    ..., Contractor Business Ethics Compliance Program and Disclosure Requirements. Response: It is important to... business. In the normal course of business, a company that is concerned about ethical behavior will take....regulations.gov , including any personal and/or business confidential information provided. FOR...

  10. 75 FR 10191 - Defense Federal Acquisition Regulation Supplement (DFARS); DFARS Case 2009-D017, Continuation of...

    Science.gov (United States)

    2010-03-05

    ... address shown below on or before May 4, 2010, to be considered in the formation of the final rule... Acquisition Regulations System, Crystal Square 4, Suite 200A, 241 18th Street, Arlington, VA 22202- 3402... components to rely on the most effective mix of the total force, cost and other factors considered,...

  11. 76 FR 49483 - Federal Acquisition Regulation; Information Collection; Organization and Direction of Work

    Science.gov (United States)

    2011-08-10

    ... Regulation; Information Collection; Organization and Direction of Work AGENCY: Department of Defense (DOD... extension of a previously approved information collection requirement concerning organization and direction... comments identified by Information Collection 9000- 0064, Organization and Direction of Work, by any of the...

  12. 78 FR 67004 - Removal of References to Credit Ratings in Certain Regulations Governing the Federal Home Loan Banks

    Science.gov (United States)

    2013-11-08

    ... establishes an exception to a general prohibition on a Bank's investment in mortgages or other whole loans, if... less than ``investment quality'' after the initial purchase.\\13\\ \\13\\ Current investment regulations, while prohibiting a Bank from buying debt instruments that are rated less than investment grade by an...

  13. Transparency and Accountability: What if the Federal Gainful Employment-Debt Measures Regulations Applied to Law Schools?

    Science.gov (United States)

    Mattox, Kari Ann

    2013-01-01

    The purpose of this analysis is to compare current guidelines of the American Bar Association (ABA) for law schools to those of the U.S. Department of Education's Gainful Employment-Debt Measures regulations in order to assess their transparency and accountability. This analysis is relevant in a time of increasing tuition costs and record…

  14. 78 FR 69273 - Defense Federal Acquisition Regulation Supplement: Safeguarding Unclassified Controlled Technical...

    Science.gov (United States)

    2013-11-18

    ... Accounting Standards (CAS) Comment: One respondent asked if the cost associated with compliance to the DFARS changes is allowable under CAS. Response: Cost Accounting Standards address measurement, allocation and....74 as stated in the proposed rule, to conform to the current DFARS baseline numbering...

  15. 75 FR 53135 - Federal Acquisition Regulation; Definition of Cost or Pricing Data

    Science.gov (United States)

    2010-08-30

    ...; Retains the current order of preference for determining the type of cost or pricing data required to... Government cost accounting data for commercial items. Response: There is no requirement for anything more... commercial companies will not comply with Cost Accounting Standards, FAR part 31, and are not...

  16. 78 FR 28780 - Defense Federal Acquisition Regulation Supplement: Detection and Avoidance of Counterfeit...

    Science.gov (United States)

    2013-05-16

    ... potential for an impact on small entities in the supply chain of a prime contractor with contracts subject... suspect counterfeit parts from entering the supply chain when procuring electronic parts or end items... counterfeit electronic parts from the supply chain. Legally authorized source means the current design...

  17. 75 FR 59411 - Defense Federal Acquisition Regulation Supplement; Patents, Data, and Copyrights (DFARS Case 2010...

    Science.gov (United States)

    2010-09-27

    ...'' rather than ``computer software.'' The items ``design details, algorithms, processes, flow charts, formulas, and related material that describe the design, organization, or structure'' of computer software... works, and architect- engineer services was moved out of current 227.71 to entirely replace the...

  18. 76 FR 25566 - Defense Federal Acquisition Regulation Supplement (DFARS); Electronic Ordering Procedures (DFARS...

    Science.gov (United States)

    2011-05-05

    ..., Ordering, currently permits ordering officials to specify e-mail as an ``electronic commerce method'' so... explicitly permit the use of e-mail as a recognized electronic commerce method. The respondent recommended... the possibility for miscommunication. Another respondent stated that electronic commerce is a...

  19. Current control loop design and analysis based on resonant regulators for microgrid applications

    DEFF Research Database (Denmark)

    Federico, de Bosio; Pastorelli, Michelle; de Sousa Ribeiro, Luiz Antonio

    2015-01-01

    Voltage and current control loops play an important role in the performance of microgrids employing power electronics voltage source inverters. Correct design of feedback loops is essential for the proper operation of these systems. This paper analyzes the influence of state feedback cross......-coupling in the design of resonant regulators for inner current loops in power converters operating in standalone microgrids. It is also demonstrated that the effect of state feedback cross-coupling degrades the performance of the control loops by increasing the steady-state error. Different resonant regulators...... structures are analyzed and compared, performing experimental tests to validate the results of the theoretical analysis....

  20. Review of current and anticipated regulations on air protection in the Czech Republic

    Energy Technology Data Exchange (ETDEWEB)

    Jilek, P.; Novotny, V. [Ministry of the Environment of the Czech Republic, Prague (Czechoslovakia)

    1995-12-01

    Environmental issues, especially the solution of the air pollution problem, have taken on great significance in the Czech Republic (which was a part of the Czech and Slovak Federal Republic until the end of 1992) since the 1989 {open_quotes}Velvet{close_quotes} Revolution. The former CSFR Federal Committee for the Environment and both the Republic Ministries started immediately with creating new environmental legislation, which is the main governmental tool for protecting the environment in the newly developing democracy state system with a market oriented economy. The inspiration for that activity was found in legislation of developed countries - member states of the European Union, and in German environmental law in particular. This paper surveys the major laws and regulations that gradually came into force in the Czech Republic since 1990. The provisions of the primary significance are the Act No.309/1991 S.B., dated July 9, 1991, on the protection of the air against pollutants - The Clean Air Act, the Act No.218/1992 S.B., dated April 27, 1992, which changes and supplements the Act No.309 - The Clean Air Act, the Measure of the Federal Committee for the Environment of October 1, 1991 to the Clean Air Act, and its amended wordings of June 23, 1992, 84/1991 S.B., and 84/1992 S.B., the Act No.389/1991 S.B., dated September 10, 1991 on the state administration of air protection and charges for the pollution of air, and several regulations based on the Act No.389/1991 S.B., issued in the period 1992 -1993.

  1. Voltage and Current Regulators Design of Power Converters in Islanded Microgrids based on State Feedback Decoupling

    DEFF Research Database (Denmark)

    Federico, de Bosio; de Sousa Ribeiro, Luiz Antonio; Freijedo Fernandez, Francisco Daniel

    2016-01-01

    In stand-alone microgrids based on voltage source inverters state feedback coupling between the capacitor voltage and inductor current degrades significantly the dynamics performance of voltage and current regulators. The decoupling of the controlled states is proposed, considering the limitations...... introduced by system delays. Moreover, a proportional resonant voltage controller is designed according to Nyquist criterion taking into account application requirements. Experimental tests performed in compliance with the UPS standards verify the theoretical analysis....

  2. Differential regulation of potassium currents by FGF-1 and FGF-2 in embryonic Xenopus laevis myocytes.

    Science.gov (United States)

    Chauhan-Patel, R; Spruce, A E

    1998-10-01

    1. Fibroblast growth factors (FGFs) are involved in the regulation of many aspects of muscle development. This study investigated their role in regulating voltage-dependent K+ currents in differentiating Xenopus laevis myocytes. Both FGF-1 and FGF-2 are expressed by developing muscle cells, so their actions were compared. Experiments were performed on cultured myocytes isolated from stage 15 embryos. 2. Long-term exposure of the embryonic myocytes to FGF-1 downregulated inward rectifier K+ current (IK(IR)) density as well as both sustained and inactivating voltage-dependent outward K+ currents (IK,S and IK,I, respectively) and their densities. In contrast, FGF-2 upregulated these currents, although, because of an increase in capacitance caused by FGF-2, current density did not change with this factor. 3. The regulation of IK(IR) by FGF-1 was prevented by the cytoplasmic tyrosine kinase inhibitor herbimycin A, but that of IK,S and IK,I was unaffected, indicating that FGF-1 achieves its regulatory effects on electrical development via separate signalling pathways. The receptor tyrosine kinase inhibitor genistein in isolation suppressed K+ currents, but this may have occurred through a channel-blocking mechanism. 4. In many cells, IK, S was found to be composed of two components with differing voltage dependencies of activation. The FGFs brought about an alteration in the amount of total IK,S by equal effects on each component. Conversely, herbimycin A increased the proportion of low voltage-activated current without affecting total current amplitude. Therefore, we suggest that a single species of channel whose voltage dependence is shifted by tyrosine phosphorylation generates IK,S. 5. In summary, FGF-1 and FGF-2 exert opposite effects on voltage-dependent K+ currents in embryonic myocytes and, furthermore, FGF-1 achieves its effects on different K+ currents via separate second messenger pathways.

  3. Environmental Education--A Future-Oriented Task: Current Situation and Prospects in the Federal Republic of Germany.

    Science.gov (United States)

    Ministry of Education and Science, Bonn (Germany).

    The Federal Republic of Germany has identified the conservation and the protection of the environment as a major challenge of the 1990s. Environmental education is further identified as an important part of anticipatory environmental policy. The document is separated into two parts. The first part presents the aims, content, and organizational…

  4. Down-regulation of endogenous KLHL1 decreases voltage-gated calcium current density.

    Science.gov (United States)

    Perissinotti, Paula P; Ethington, Elizabeth G; Cribbs, Leanne; Koob, Michael D; Martin, Jody; Piedras-Rentería, Erika S

    2014-05-01

    The actin-binding protein Kelch-like 1 (KLHL1) can modulate voltage-gated calcium channels in vitro. KLHL1 interacts with actin and with the pore-forming subunits of Cav2.1 and CaV3.2 calcium channels, resulting in up-regulation of P/Q and T-type current density. Here we tested whether endogenous KLHL1 modulates voltage gated calcium currents in cultured hippocampal neurons by down-regulating the expression of KLHL1 via adenoviral delivery of shRNA targeted against KLHL1 (shKLHL1). Control adenoviruses did not affect any of the neuronal properties measured, yet down-regulation of KLHL1 resulted in HVA current densities ~68% smaller and LVA current densities 44% smaller than uninfected controls, with a concomitant reduction in α(1A) and α(1H) protein levels. Biophysical analysis and western blot experiments suggest Ca(V)3.1 and 3.3 currents are also present in shKLHL1-infected neurons. Synapsin I levels, miniature postsynaptic current frequency, and excitatory and inhibitory synapse number were reduced in KLHL1 knockdown. This study corroborates the physiological role of KLHL1 as a calcium channel modulator and demonstrates a novel, presynaptic role.

  5. Exploring Faraday's Law of Electrolysis Using Zinc-Air Batteries with Current Regulative Diodes

    Science.gov (United States)

    Kamata, Masahiro; Paku, Miei

    2007-01-01

    Current regulative diodes (CRDs) are applied to develop new educational experiments on Faraday's law by using a zinc-air battery (PR2330) and a resistor to discharge it. The results concluded that the combination of zinc-air batteries and the CRD array is simpler, less expensive, and quantitative and gives accurate data.

  6. A NOVEL CONTROL STRATEGY FOR SINUSIODAL WAVE INVERTER WITH PI REGULATORS AND CAPACITOR CURRENT FEEDBACK

    Institute of Scientific and Technical Information of China (English)

    姜桂宾; 裴云庆; 王兆安

    2003-01-01

    Objective For the inverters used in UPS, it is important to maintain the pure sinusoidal AC output voltage waveform over all loading conditions and transients. Methods A novel sinusoidal output voltage control strategy is pregented in this paper. The output voltage is controlled by introducing filtering eapacitor current feedback. Two simple PI regulators are used for the current and voltage control loops. Results With the new control strategy, the inverter achieves very low output voltage distortion, good output voltage regulation and strong perturbation rejection, fast dynamic response, and good performance under nonlinear loads. The THD under capacitance rectifying load is better than 0.2%, the output voltage regulation within 0 to full load is less than 0.1%. The resting time under load transient is within 200μs. Conclusion The merits of the new control strategy include rapid response and good steady state stiffness.

  7. Characterization of Mg2+-regulated TRPM7-like current in human atrial myocytes

    Directory of Open Access Journals (Sweden)

    Macianskiene Regina

    2012-08-01

    Full Text Available Abstract Background TRPM7 (Transient Receptor Potential of the Melastatin subfamily proteins are highly expressed in the heart, however, electrophysiological studies, demonstrating and characterizing these channels in human cardiomyocytes, are missing. Methods We have used the patch clamp technique to characterize the biophysical properties of TRPM7 channel in human myocytes isolated from right atria small chunks obtained from 116 patients in sinus rhythm during coronary artery and valvular surgery. Under whole-cell voltage-clamp, with Ca2+ and K+ channels blocked, currents were generated by symmetrical voltage ramp commands to potentials between -120 and +80 mV, from a holding potential of -80 mV. Results We demonstrate that activated native current has dual control by intracellular Mg2+ (free-Mg2+ or ATP-bound form, and shows up- or down-regulation by its low or high levels, respectively, displaying outward rectification in physiological extracellular medium. High extracellular Mg2+ and Ca2+ block the outward current, while Gd3+, SpM4+, 2-APB, and carvacrol inhibit both (inward and outward currents. Besides, divalents also permeate the channel, and the efficacy sequence, at 20 mM, was Mg2+>Ni2+>Ca2+>Ba2+>Cd2+ for decreasing outward and Ni2+>Mg2+>Ba2+≥Ca2+>Cd2+ for increasing inward currents. The defined current bears many characteristics of heterologously expressed or native TRPM7 current, and allowed us to propose that current under study is TRPM7-like. However, the time of beginning and time to peak as well steady state magnitude (range from 1.21 to 11.63 pA/pF, ncells/patients = 136/77 of induced TRPM7-like current in atrial myocytes from different patients showed a large variability, while from the same sample of human atria all these parameters were very homogenous. We present new information that TRPM7-like current in human myocytes is less sensitive to Mg2+. In addition, in some myocytes (from 24 out of 77 patients that current

  8. Power lateral pnp transistor operating with high current density in irradiated voltage regulator

    Directory of Open Access Journals (Sweden)

    Vukić Vladimir Đ.

    2013-01-01

    Full Text Available The operation of power lateral pnp transistors in gamma radiation field was examined by detection of the minimum dropout voltage on heavily loaded low-dropout voltage regulators LM2940CT5, clearly demonstrating their low radiation hardness, with unacceptably low values of output voltage and collector-emitter voltage volatility. In conjunction with previous results on base current and forward emitter current gain of serial transistors, it was possible to determine the positive influence of high load current on a slight improvement of voltage regulator LM2940CT5 radiation hardness. The high-current flow through the wide emitter aluminum contact of the serial transistor above the isolation oxide caused intensive annealing of the positive oxide-trapped charge, leading to decrease of the lateral pnp transistor's current gain, but also a more intensive recovery of the small-signal npn transistors in the control circuit. The high current density in the base area of the lateral pnp transistor immediately below the isolation oxide decreased the concentration of negative interface traps. Consequently, the positive influence of the reduced concentration of the oxide-trapped charge on the negative feedback reaction circuit, together with the favourable effect of reduced interface traps concentration, exceeded negative influence of the annealed oxide-trapped charge on the serial pnp transistor's forward emitter current gain.

  9. A Fiscal Cliff: The Current U.S. Federal Budget, Potential Cuts, and Impacts on Science Funding

    Science.gov (United States)

    Uhlenbrock, K. M.; Landau, E. A.; Hankin, E. R.

    2012-12-01

    As lawmakers on Capitol Hill face challenges to reach an agreement on how to cut the deficit while growing the economy, scientists must join the discussion and outline the serious impacts cuts to federal science programs will have on our society. Consistent and sustained federal science funding (discretionary spending) is an ever increasing struggle with the rising costs of mandatory spending and decrease in revenues. In 2011 Congress passed the Budget Control Act, which will require automatic across-the-board cuts, known as sequestration, and will take effect on 2 January 2013. Estimated cuts of $1.2 trillion and discretionary spending caps set at Fiscal Year 2012 levels will trigger non-defense program cuts of 9.8% in the first year as reported by the Congressional Research Service. Funding from non-defense program agencies such as NSF, NASA, DOE, NOAA, USGS, and others drive science and technological innovation, support public safety, create jobs, educate generations of scientists, stimulate the economy, protect our environment, and enrich lives. With non-defense discretionary programs representing less than one-fifth of the federal budget, severe cuts to these programs will not alleviate our deficit, but instead restrict our growth.

  10. Pacemaker neuron and network oscillations depend on a neuromodulator-regulated linear current

    Directory of Open Access Journals (Sweden)

    Shunbing Zhao

    2010-05-01

    Full Text Available Linear leak currents have been implicated in the regulation of neuronal excitability, generation of neuronal and network oscillations, and network state transitions. Yet, few studies have directly tested the dependence of network oscillations on leak currents or explored the role of leak currents on network activity. In the oscillatory pyloric network of decapod crustaceans neuromodulatory inputs are necessary for pacemaker activity. A large subset of neuromodulators is known to activate a single voltage-gated inward current IMI, which has been shown to regulate the rhythmic activity of the network and its pacemaker neurons. Using the dynamic clamp technique, we show that the crucial component of IMI for the generation of oscillatory activity is only a close-to-linear portion of the current-voltage relationship. The nature of this conductance is such that the presence or the absence of neuromodulators effectively regulates the amount of leak current and the input resistance in the pacemaker neurons. When deprived of neuromodulatory inputs, pyloric oscillations are disrupted; yet, a linear reduction of the total conductance in a single neuron within the pacemaker group recovers not only the pacemaker activity in that neuron, but also leads to a recovery of oscillations in the entire pyloric network. The recovered activity produces proper frequency and phasing that is similar to that induced by neuromodulators. These results show that the passive properties of pacemaker neurons can significantly affect their capacity to generate and regulate the oscillatory activity of an entire network, and that this feature is exploited by neuromodulatory inputs.

  11. 77 FR 5252 - Federal Travel Regulation; GSA E-Gov Travel Service (ETS) Transition to E-Gov Travel Service 2...

    Science.gov (United States)

    2012-02-02

    ... ADMINISTRATION Federal Travel Regulation; GSA E-Gov Travel Service (ETS) Transition to E-Gov Travel Service 2... of a bulletin. SUMMARY: The attached bulletin announces GSA ETS Transition to ETS2. DATES: Effective.... Frank Robinson, ETS Program Manager Center for Travel Management (QMCD), Office of Travel and...

  12. EPA, CARB to Hold Media Call to Announce First-Ever Federal Enforcement Action For Violations of the California Truck and Bus Regulation

    Science.gov (United States)

    LOS ANGELES - On Thursday, at 10:30 a.m. PST, U.S. EPA Regional Administrator Jared Blumenfeld will hold a press call to announce the results of the first-ever federal enforcement action for violations of the California Truck and Bus Regulation by Estes Ex

  13. Sensory deprivation regulates the development of the hyperpolarization-activated current in auditory brainstem neurons.

    Science.gov (United States)

    Hassfurth, Benjamin; Magnusson, Anna K; Grothe, Benedikt; Koch, Ursula

    2009-10-01

    Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels are highly expressed in the superior olivary complex, the primary locus for binaural information processing. This hyperpolarization-activated current (I(h)) regulates the excitability of neurons and enhances the temporally precise analysis of the binaural acoustic cues. By using the whole-cell patch-clamp technique, we examined the properties of I(h) current in neurons of the lateral superior olive (LSO) and the medial nucleus of the trapezoid body (MNTB) before and after hearing onset. Moreover, we tested the hypothesis that I(h) currents are actively regulated by sensory input activity by performing bilateral and unilateral cochlear ablations before hearing onset, resulting in a chronic auditory deprivation. The results show that after hearing onset, I(h) currents are rapidly upregulated in LSO neurons, but change only marginally in neurons of the MNTB. We also found a striking difference in maximal current density, voltage dependence and activation time constant between the LSO and the MNTB in mature-like animals. Following bilateral cochlear ablations before hearing onset, the I(h) currents were scaled up in the LSO and scaled down in the MNTB. Consequently, in the LSO this resulted in a depolarized resting membrane potential and a lower input resistance of these neurons. This type of activity-dependent homeostatic change could thus result in an augmented response to the remaining inputs.

  14. LED Current Balance Using a Variable Voltage Regulator with Low Dropout vDS Control

    Directory of Open Access Journals (Sweden)

    Hung-I Hsieh

    2017-02-01

    Full Text Available A cost-effective light-emitting diode (LED current balance strategy using a variable voltage regulator (VVR with low dropout vDS control is proposed. This can regulate the multiple metal-oxide-semiconductor field-effect transistors (MOSFETs of the linear current regulators (LCR, maintaining low dropout vDS on the flat vGS-characteristic curves and making all drain currents almost the same. Simple group LCRs respectively loaded with a string LED are employed to implement the theme. The voltage VVdc from a VVR is synthesized by a string LED voltage NvD, source voltage vR, and a specified low dropout vDS = VQ. The VVdc updates instantly, through the control loop of the master LCR, which means that all slave MOSFETs have almost the same biases on their flat vGS-characteristic curves. This leads to all of the string LED currents being equal to each other, producing an almost even luminance. An experimental setup with microchip control is built to verify the estimations. Experimental results show that the luminance of all of the string LEDs are almost equal to one another, with a maximum deviation below 1% during a wide dimming range, while keeping all vDS of the MOSFETs at a low dropout voltage, as expected.

  15. Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability

    Science.gov (United States)

    Paul, Jodi R.; Dewoskin, Daniel; McMeekin, Laura J.; Cowell, Rita M.; Forger, Daniel B.; Gamble, Karen L.

    2016-11-01

    How neurons encode intracellular biochemical signalling cascades into electrical signals is not fully understood. Neurons in the central circadian clock in mammals provide a model system to investigate electrical encoding of biochemical timing signals. Here, using experimental and modelling approaches, we show how the activation of glycogen synthase kinase 3 (GSK3) contributes to neuronal excitability through regulation of the persistent sodium current (INaP). INaP exhibits a day/night difference in peak magnitude and is regulated by GSK3. Using mathematical modelling, we predict and confirm that GSK3 activation of INaP affects the action potential afterhyperpolarization, which increases the spontaneous firing rate without affecting the resting membrane potential. Together, these results demonstrate a crucial link between the molecular circadian clock and electrical activity, providing examples of kinase regulation of electrical activity and the propagation of intracellular signals in neuronal networks.

  16. On-line monitoring of base current and forward emitter current gain of the voltage regulator's serial pnp transistor in a radiation environment

    Directory of Open Access Journals (Sweden)

    Vukić Vladimir Đ.

    2012-01-01

    Full Text Available A method of on-line monitoring of the low-dropout voltage regulator's operation in a radiation environment is developed in this paper. The method had to enable detection of the circuit's degradation during exploitation, without terminating its operation in an ionizing radiation field. Moreover, it had to enable automatic measurement and data collection, as well as the detection of any considerable degradation, well before the monitored voltage regulator's malfunction. The principal parameters of the voltage regulator's operation that were monitored were the serial pnp transistor's base current and the forward emitter current gain. These parameters were procured indirectly, from the data on the voltage regulator's load and quiescent currents. Since the internal consumption current in moderately and heavily loaded devices was used, the quiescent current of a negligibly loaded voltage regulator of the same type served as a reference. Results acquired by on-line monitoring demonstrated marked agreement with the results acquired from examinations of the voltage regulator's maximum output current and minimum dropout voltage in a radiation environment. The results were particularly consistent in tests with heavily loaded devices. Results obtained for moderately loaded voltage regulators and the risks accompanying the application of the presented method, were also analyzed.

  17. SOME CONSIDERATIONS OVER THE INTERNAL CONTROL IN THE CONTEXT OF CURRENT ACCOUNTANCY REGULATIONS

    Directory of Open Access Journals (Sweden)

    Lenghel Dorin Radu

    2012-12-01

    Full Text Available Through the hereby study we set ourselves on an analysis over the internal control and the ways of implementation of it. The final purpose of our research is represented by the characteristics of the internal control system in the context of current accountancy regulations. The accomplishment of such goal has forced us to research the current literature in the area and also the legal regulations over internal control. Of course, the accomplishment of such a research was possible only after a pertinent analysis over the opinions expressed in specialty literature regarding this area. Our research wants to be with a theoretical and applicative character. It is based on analysing the internal control system, the methodology of internal control and the steps of internal control. We express our belief that the implementation of the internal control in a very exact manner comes as an aid to the company management and lead to the accomplishment of managerial objectives and policies. In what it regards the result of our research there can be drawn the following conclusions: from the legal regulations (OMFP nr. 3055/2009, there is no clear conclusion over the procedures and policies of implementation of internal control applicable to an economical entity; also there are not presented in a detailed way the types (forms of internal control, being presented in the legal regulations only a classification of them after the time in which they are exercised (before, during or after the finishing of the operations; also in the legal regulations there is developed a certain way of internal control, represented by the financial and accounting internal control, as if the other forms of internal control do not exist; in what regards the components of internal control, these are presented in another way, but similar to already known models of internal control (Coso and Coco; also in the legal regulations there are presented the general objectives of internal control

  18. Quality Managment Program (QMP) report: A review of quality management programs developed in response to Title 10, Section 35.32 of the Code of Federal Regulations

    Energy Technology Data Exchange (ETDEWEB)

    Witte, M.C.

    1994-10-01

    In July of 1991, the Nuclear Regulatory Commission published a Final Rule in the Federal Register amending regulations governing medical therapeutic administrations of byproduct material and certain uses of radioactive sodium iodide. These amendments required implementation of a Quality Management Program (QMP) to provide high confidence that the byproduct material -- or radiation from byproduct material -- will be administered as directed by an authorized user physician. Herein, this rule is referred to as the QM rule. The Final Rule was published after two proposed rules had been published in the Federal Register.

  19. Radioprotective drugs: a synopsis of current research and a proposed research plan for the Federal Emergency Management Agency. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Hickman, R.; Anspaugh, L.

    1985-04-01

    FEMA has broad roles in the management of disasters potentially involving substantial amounts of radioactive contamination. These could be either peacetime or wartime disasters. A meeting was held in March 1985 to see if there are any research contributions that FEMA might reasonably make in the area of radioprotective drugs that would substantially enhance its ability to perform its mission. The other federal agencies presently sponsoring research in the field were represented at the meeting. A few selected researchers also participated to provide complementary viewpoints. Activities of a modest scale that FEMA might undertake were identified, as were larger scale activities that might be undertaken in the event of long-term, major funding-level increases for FEMA. 2 refs.

  20. 78 FR 19193 - Richard Phillips, Currently Incarcerated at: Inmate No. 81783-079, FCI Ray Brook Federal...

    Science.gov (United States)

    2013-03-29

    ... Bureau of Industry and Security Richard Phillips, Currently Incarcerated at: Inmate No. 81783- 079, FCI.... District Court, Eastern District of New York, Richard Phillips (``Phillips'') was convicted of violating...)) (``IEEPA''). Specifically, Phillips was convicted of knowingly, intentionally and willfully attempting to...

  1. Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels.

    Science.gov (United States)

    Aman, Teresa K; Grieco-Calub, Tina M; Chen, Chunling; Rusconi, Raffaella; Slat, Emily A; Isom, Lori L; Raman, Indira M

    2009-02-18

    The beta subunits of voltage-gated Na channels (Scnxb) regulate the gating of pore-forming alpha subunits, as well as their trafficking and localization. In heterologous expression systems, beta1, beta2, and beta3 subunits influence inactivation and persistent current in different ways. To test how the beta4 protein regulates Na channel gating, we transfected beta4 into HEK (human embryonic kidney) cells stably expressing Na(V)1.1. Unlike a free peptide with a sequence from the beta4 cytoplasmic domain, the full-length beta4 protein did not block open channels. Instead, beta4 expression favored open states by shifting activation curves negative, decreasing the slope of the inactivation curve, and increasing the percentage of noninactivating current. Consequently, persistent current tripled in amplitude. Expression of beta1 or chimeric subunits including the beta1 extracellular domain, however, favored inactivation. Coexpressing Na(V)1.1 and beta4 with beta1 produced tiny persistent currents, indicating that beta1 overcomes the effects of beta4 in heterotrimeric channels. In contrast, beta1(C121W), which contains an extracellular epilepsy-associated mutation, did not counteract the destabilization of inactivation by beta4 and also required unusually large depolarizations for channel opening. In cultured hippocampal neurons transfected with beta4, persistent current was slightly but significantly increased. Moreover, in beta4-expressing neurons from Scn1b and Scn1b/Scn2b null mice, entry into inactivated states was slowed. These data suggest that beta1 and beta4 have antagonistic roles, the former favoring inactivation, and the latter favoring activation. Because increased Na channel availability may facilitate action potential firing, these results suggest a mechanism for seizure susceptibility of both mice and humans with disrupted beta1 subunits.

  2. pH-regulated ionic current rectification in conical nanopores functionalized with polyelectrolyte brushes.

    Science.gov (United States)

    Zeng, Zhenping; Ai, Ye; Qian, Shizhi

    2014-02-14

    Mimicking biological ion channels capable of pH-regulated ionic transport, synthetic nanopores functionalized with pH-tunable polyelectrolyte (PE) brushes have been considered as versatile tools for active transport control of ions, fluids, and bioparticles on the nanoscale. The ionic current rectification (ICR) phenomenon through a conical nanopore functionalized with PE brushes whose charge highly depends upon the local solution properties (i.e., pH and background salt concentration) is studied theoretically for the first time. The results show that the rectification magnitude, as well as the preferential rectification direction, is sensitive to the pH stimulus. The bulk concentration of the background salt can also significantly influence the charge of the PE brushes and accordingly affect the ICR phenomenon. The obtained results provide an insightful understanding of the pH-regulated ICR and guidelines for designing nanopores functionalized with PE brushes for pH-tunable applications.

  3. Current practices and reform proposals for the regulation of advanced medicinal products in Canada.

    Science.gov (United States)

    Viswanathan, Sowmya; Bubela, Tania

    2015-01-01

    We describe the Canadian regulatory framework for evaluating advanced medicinal products based on current policies, guidance documents and regulations and analyze proposed reforms. Our analysis is based on a documentary review supplemented by discussions with Health Canada officials. We present an overview of the Canadian regulatory framework for cell and gene therapy, medical devices and manufacturing facilities. We use the approval of Prochymal™ to highlight Canada's conditional marketing approval system. Finally, we discuss proposed changes to the regulatory framework in response to identified gaps, stakeholder consultations and international harmonization initiatives. Based on our analyses, we suggest that Canadian regulators have taken a reasonable approach in applying their regulatory framework without compromising on product safety.

  4. Current Insights to Regulation and Role of Telomerase in Human Diseases

    Science.gov (United States)

    Ozturk, Mert Burak; Li, Yinghui; Tergaonkar, Vinay

    2017-01-01

    The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation and senescence of normal somatic cells as well as cancer cells. This complex is comprised mainly of telomerase reverse transcriptase (TERT), telomerase RNA component (TERC) and other associated proteins that function to elongate telomeres localized at the end of the chromosomes. While reactivation of telomerase is a major hallmark of most cancers, together with the synergistic activation of other oncogenic signals, deficiency in telomerase and telomeric proteins might lead to aging and senescence-associated disorders. Therefore, it is critically important to understand the canonical as well as non-canonical functions of telomerase through TERT to develop a therapeutic strategy against telomerase-related diseases. In this review, we shed light on the regulation and function of telomerase, and current therapeutic strategies against telomerase in cancer and age-related diseases. PMID:28264499

  5. A Title 40 Code of Federal Regulations Part 191 Evaluation of Buried Transuranic Waste at the Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    G. J. Shott, V. Yucel, L. Desotell

    2008-04-01

    In 1986, 21 m{sup 3} of transuranic (TRU) waste was inadvertently buried in a shallow land burial trench at the Area 5 Radioactive Waste Management Site on the Nevada Test Site (NTS). The U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office is considered five options for management of the buried TRU waste. One option is to leave the waste in-place if the disposal can meet the requirements of Title 40 Code of Federal Regulations (CFR) Part 191, 'Environmental Radiation Protection Standard for Management and Disposal of Spent Nuclear Fuel, High-Level, and Transuranic Radioactive Wastes'. This paper describes analyses that assess the likelihood that TRU waste in shallow land burial can meet the 40 CFR 191 standards for a geologic repository. The simulated probability of the cumulative release exceeding 1 and 10 times the 40 CFR 191.13 containment requirements is estimated to be 0.009 and less than 0.0001, respectively. The cumulative release is most sensitive to the number of groundwater withdrawal wells drilled through the disposal trench. The mean total effective dose equivalent for a member of the public is estimated to reach a maximum of 0.014 milliSievert (mSv) at 10,000 years, or approximately 10 percent of the 0.15 mSv 40 CFR 191.15 individual protection requirement. The dose is predominantly from inhalation of short-lived Rn-222 progeny in air produced by low-level waste disposed in the same trench. The transuranic radionuclide released in greatest amounts, Pu-239, contributes only 0.4 percent of the dose. The member of public dose is most sensitive to the U-234 inventory and the radon emanation coefficient. Reasonable assurance of compliance with the Subpart C groundwater protection standard is provided by site characterization data and hydrologic processes modeling which support a conclusion of no groundwater pathway within 10,000 years. Limited quantities of transuranic waste in a shallow land burial trench at the

  6. [On the implementation by Rospotrebnadzor (Federal service for the oversight of consumer protection and welfare) common principles and rules of technical regulation within the agreement of the Customs Union].

    Science.gov (United States)

    Onishchenko, G G

    2013-01-01

    In accordance with the Agreement of the Customs Union on sanitary measures between the Government of the Russian Federation, the Republic of Belarus and the Republic of Kazakhstan in the customs territory of the Customs Union the Uniform sanitary and epidemiological and hygienic requirements for goods subject to sanitary-epidemiological control are applied. Common sanitary requirements are binding for executive authorities of the Member States of the Customs union, local authorities, legal persons, whatever legalform, individual entrepreneurs, individuals. Currently, out of 47 planned to take priority technical regulations of the Customs Union 31 regulation, including the safety of railway rolling stock, production of perfumery and cosmetics, toys and products for children and teenagers, food products, grain, and other furniture products was adopted.

  7. Carbohydrate Metabolism in Archaea: Current Insights into Unusual Enzymes and Pathways and Their Regulation

    Science.gov (United States)

    Esser, Dominik; Rauch, Bernadette

    2014-01-01

    SUMMARY The metabolism of Archaea, the third domain of life, resembles in its complexity those of Bacteria and lower Eukarya. However, this metabolic complexity in Archaea is accompanied by the absence of many “classical” pathways, particularly in central carbohydrate metabolism. Instead, Archaea are characterized by the presence of unique, modified variants of classical pathways such as the Embden-Meyerhof-Parnas (EMP) pathway and the Entner-Doudoroff (ED) pathway. The pentose phosphate pathway is only partly present (if at all), and pentose degradation also significantly differs from that known for bacterial model organisms. These modifications are accompanied by the invention of “new,” unusual enzymes which cause fundamental consequences for the underlying regulatory principles, and classical allosteric regulation sites well established in Bacteria and Eukarya are lost. The aim of this review is to present the current understanding of central carbohydrate metabolic pathways and their regulation in Archaea. In order to give an overview of their complexity, pathway modifications are discussed with respect to unusual archaeal biocatalysts, their structural and mechanistic characteristics, and their regulatory properties in comparison to their classic counterparts from Bacteria and Eukarya. Furthermore, an overview focusing on hexose metabolic, i.e., glycolytic as well as gluconeogenic, pathways identified in archaeal model organisms is given. Their energy gain is discussed, and new insights into different levels of regulation that have been observed so far, including the transcript and protein levels (e.g., gene regulation, known transcription regulators, and posttranslational modification via reversible protein phosphorylation), are presented. PMID:24600042

  8. An energy-efficient, adiabatic electrode stimulator with inductive energy recycling and feedback current regulation.

    Science.gov (United States)

    Arfin, Scott K; Sarpeshkar, Rahul

    2012-02-01

    In this paper, we present a novel energy-efficient electrode stimulator. Our stimulator uses inductive storage and recycling of energy in a dynamic power supply. This supply drives an electrode in an adiabatic fashion such that energy consumption is minimized. It also utilizes a shunt current-sensor to monitor and regulate the current through the electrode via feedback, thus enabling flexible and safe stimulation. Since there are no explicit current sources or current limiters, wasteful energy dissipation across such elements is naturally avoided. The dynamic power supply allows efficient transfer of energy both to and from the electrode and is based on a DC-DC converter topology that we use in a bidirectional fashion in forward-buck or reverse-boost modes. In an exemplary electrode implementation intended for neural stimulation, we show how the stimulator combines the efficiency of voltage control and the safety and accuracy of current control in a single low-power integrated-circuit built in a standard .35 μm CMOS process. This stimulator achieves a 2x-3x reduction in energy consumption as compared to a conventional current-source-based stimulator operating from a fixed power supply. We perform a theoretical analysis of the energy efficiency that is in accord with experimental measurements. This theoretical analysis reveals that further improvements in energy efficiency may be achievable with better implementations in the future. Our electrode stimulator could be widely useful for neural, cardiac, retinal, cochlear, muscular and other biomedical implants where low power operation is important.

  9. A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism

    Directory of Open Access Journals (Sweden)

    Yanlin He

    2016-11-01

    Full Text Available Neurons that co-express agouti-related peptide (AgRP and neuropeptide Y (NPY are indispensable for normal feeding behavior. Firing activities of AgRP/NPY neurons are dynamically regulated by energy status and coordinate appropriate feeding behavior to meet nutritional demands. However, intrinsic mechanisms that regulate AgRP/NPY neural activities during the fed-to-fasted transition are not fully understood. We found that AgRP/NPY neurons in satiated mice express high levels of the small-conductance calcium-activated potassium channel 3 (SK3 and are inhibited by SK3-mediated potassium currents; on the other hand, food deprivation suppresses SK3 expression in AgRP/NPY neurons, and the decreased SK3-mediated currents contribute to fasting-induced activation of these neurons. Genetic mutation of SK3 specifically in AgRP/NPY neurons leads to increased sensitivity to diet-induced obesity, associated with chronic hyperphagia and decreased energy expenditure. Our results identify SK3 as a key intrinsic mediator that coordinates nutritional status with AgRP/NPY neural activities and animals’ feeding behavior and energy metabolism.

  10. 75 FR 13421 - Federal Acquisition Regulation; FAR Case 2008-036, Trade Agreements-Costa Rica, Oman, and Peru

    Science.gov (United States)

    2010-03-19

    .... SUPPLEMENTARY INFORMATION: A. Background The Councils published an interim rule in the Federal Register at 74 FR... 74 FR 28426 on June 15, 2009, is adopted as a final rule without change. BILLING CODE 6820-EP-S ... Peru AGENCIES: Department of Defense (DoD), General Services Administration (GSA), ] and...

  11. 25 CFR 900.5 - Effect of these regulations on Federal program guidelines, manual, or policy directives.

    Science.gov (United States)

    2010-04-01

    ..., manual, or policy directives. 900.5 Section 900.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... on Federal program guidelines, manual, or policy directives. Except as specifically provided in the Act, or as specified in subpart J, an Indian tribe or tribal organization is not required to abide by...

  12. A fast transient response low dropout regulator with current control methodology

    Institute of Scientific and Technical Information of China (English)

    Ma Zhuo; Guo Yang; Duan Zhikui; Xie Lunguo; Chen Jihua; Yu Jinshan

    2011-01-01

    A transient performance optimized CCL-LDO regulator is proposed.In the CCL-LDO,the control method of the charge pump phase-locked loop is adopted.A current control loop has the feedback signal and reference current to be compared,and then a loop filter generates the gate voltage of the power MOSFET by integrating the error current.The CCL-LDO has the optimized damping coefficient and natural resonant frequency,while its output voltage can be sub-1-V and is not restricted by the reference voltage.With a 1μF decoupling capacitor,the experimental results based on a 0.13 μm CMOS process show that the output voltage is 1.0 V; when the workload changes from 100 μA to 100 mA transiently,the stable dropout is 4.25 mV,the settling time is 8.2 μs and the undershoot is 5.11 mV; when the workload changes from 1 00 mA to 100 μA transiently,the stable dropout is 4.25 mV,the settling time is 23.3 μs and the overshoot is 6.21 mV.The PSRR value is more than -95 dB.Most of the attributes of the CCL-LDO are improved rapidly with a FOM value of 0.0097.

  13. Current regulators for I/SUP 2/L circuits to be operated from low-voltage power supplies

    DEFF Research Database (Denmark)

    Bruun, Erik; Hansen, Ole

    1980-01-01

    A new bandgap current reference is described which can be used to control the injector current of I/SUP 2/L circuits for supply voltages down to about 1 V. For small currents the total injector current is obtained as a mirror of the reference current. For large injector currents the current control...... is performed by a series regulator which compares the injector current of one I/SUP 2/L gate to the reference current. The described reference current can be adjusted to give a variation with temperature of about 60 ppm/°C over the temperature range -10 to +70°C. However, in some applications a nonzero......, but well controlled temperature coefficient is desired. It is shown how a temperature stable ring oscillator with I/SUP 2/L gates can be constructed by tailoring the temperature dependence of the supply current appropriately....

  14. Design of Current-Controller with PR-regulator for LCL-Filter Based Grid-Connected Converter

    DEFF Research Database (Denmark)

    Zeng, Guohong; Rasmussen, Tonny Wederberg

    2010-01-01

    In the application of LCL-filter based converters, the structure and parameters of current-controller is very important for the system stability and output current quality. This paper presents a filter-capacitor current feedback control scheme for grid-connected converter. The controller...... is consisted of a proportional-resonance regulator and a proportional regulator. Unlike the existing control strategy with unit capacitor current feedback, the proposed method applies the proportional regulator to the feedback path, which can decouple these two regulators, and simplify the tuning process....... Controller parameters are tuned with the aid of root-locus of system close-loop transfer function, which can provide better grasp of the influence of individual parameters and make the design process visible and holistic without any simplification and assumption. The validity, reasonability and feasibility...

  15. [Peculiarities of regulation of legal relations in the field of environmental and hygiene safety of the population in The Russian Federation at the present stage].

    Science.gov (United States)

    Karelin, A O; Eremin, G B; Lomtev, A Iu

    2012-01-01

    The results of the comparative legal analysis of the legislation of the Russian Federation in the field of environmental security have been presented, theoretical and legal basis for the subsequent development of recommendations for the development and harmonization of legislation in the field of providing environmental security and environmental protection has been defined. The formation of ecological civil law and conceptual questions of territory development guaranteeing ecological safety have been considered. Objects of the study were international treaties, Constitution of Russian Federation, Law on Environmental Protection, Land Code and other laws containing positions concerning ecological safety and environmental protection. Identified as a result of the present study the contradictions in the area of law allow to develop and submit proposals for the improvement of legal regulation in the field of environmental and hygienic safety.

  16. Former Soviet Regulations for seismic design of NPPs and comparison with current international practice

    Energy Technology Data Exchange (ETDEWEB)

    Kostarev, V.; Schukin, A.; Berkovski, A. [CKTI-Vibroseism Co. Ltd. (Cape Verde)

    1997-03-01

    This paper presents a summary of current earthquake design criteria used in former Soviet Regulations for equipment and piping systems of nuclear power plants in light of those used in United States and Japan. The detailed comparative seismic analysis of PWR (WWER) Primary Coolant Loop System (PCLS) according to Former Soviet (Russian) PNAE Code and ASME BPV Code with some comments regarding to Japan Code JEAG - 4601 was undertaken for better understanding of the differences and coincidences of seismic design criteria and requirements. The selection of these three guides for the study has very simple explanation: according to ASME BVPC, JEAG and PNAE the huge majority of existing NPPs has been designed. (J.P.N.)

  17. Current advances in DNA repair: regulation of enzymes and pathways involved in maintaining genomic stability.

    Science.gov (United States)

    Neher, Tracy M; Turchi, John J

    2011-06-15

    Novel discoveries in the DNA repair field have lead to continuous and rapid advancement of our understanding of not only DNA repair but also DNA replication and recombination. Research in the field transcends numerous areas of biology, biochemistry, physiology, and medicine, making significant connections across these broad areas of study. From early studies conducted in bacterial systems to current analyses in eukaryotic systems and human disease, the innovative research into the mechanisms of repair machines and the consequences of ineffective DNA repair has impacted a wide scientific community. This Forum contains a select mix of primary research articles in addition to a number of timely reviews covering a subset of DNA repair pathways where recent advances and novel discoveries are improving our understanding of DNA repair, its regulation, and implications to human disease.

  18. A role of stretch-activated potassium currents in the regulation of uterine smooth muscle contraction

    Institute of Scientific and Technical Information of China (English)

    Iain L O BUXTON; Nathanael HEYMAN; Yi-ying WU; Scott BARNETT; Craig ULRICH

    2011-01-01

    Rates of premature birth are alarming and threaten societies and healthcare systems worldwide. Premature labor results in premature birth in over 50% of cases. Preterm birth accounts for three-quarters of infant morbidity and mortality. Children that survive birth before 34 weeks gestation often face life-long disability. Current treatments for preterm labor are wanting. No treatment has been found to be generally effective and none are systematically evaluated beyond 48 h. New approaches to the treatment of preterm labor are desperately needed. Recent studies from our laboratory suggest that the uterine muscle is a unique compartment with regulation of uterine relaxation unlike that of other smooth muscles. Here we discuss recent evidence that the mechanically activated 2-pore potassium channel, TREK-1, may contribute to contraction-relaxation signaling in uterine smooth muscle and that TREK-1 gene variants associated with human labor and preterm labor may lead to a better understanding of preterm labor and its possible prevention.

  19. Electricity Transmission, Pipelines, and National Trails: An Analysis of Current and Potential Intersections on Federal Lands in the Eastern United States, Alaska, and Hawaii

    Energy Technology Data Exchange (ETDEWEB)

    Kuiper, James A. [Argonne National Lab. (ANL), Argonne, IL (United States); Krummel, John R. [Argonne National Lab. (ANL), Argonne, IL (United States); Hlava, Kevin J. [Argonne National Lab. (ANL), Argonne, IL (United States); Moore, H. Robert [Argonne National Lab. (ANL), Argonne, IL (United States); Orr, Andrew B. [Argonne National Lab. (ANL), Argonne, IL (United States); Schlueter, Scott O. [Argonne National Lab. (ANL), Argonne, IL (United States); Sullivan, Robert G. [Argonne National Lab. (ANL), Argonne, IL (United States); Zvolanek, Emily A. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-11-21

    As has been noted in many reports and publications, acquiring new or expanded rights-of-way for transmission is a challenging process, because numerous land use and land ownership constraints must be overcome to develop pathways suitable for energy transmission infrastructure. In the eastern U.S., more than twenty federally protected national trails (some of which are thousands of miles long, and cross many states) pose a potential obstacle to the development of new or expanded electricity transmission capacity. However, the scope of this potential problem is not well-documented, and there is no baseline information available that could allow all stakeholders to study routing scenarios that could mitigate impacts on national trails. This report, Electricity Transmission, Pipelines, and National Trails: An Analysis of Current and Potential Intersections on Federal Lands in the Eastern United States, was prepared by the Environmental Science Division of Argonne National Laboratory (Argonne). Argonne was tasked by DOE to analyze the “footprint” of the current network of National Historic and Scenic Trails and the electricity transmission system in the 37 eastern contiguous states, Alaska, and Hawaii; assess the extent to which national trails are affected by electrical transmission; and investigate the extent to which national trails and other sensitive land use types may be affected in the near future by planned transmission lines. Pipelines are secondary to transmission lines for analysis, but are also within the analysis scope in connection with the overall directives of Section 368 of the Energy Policy Act of 2005, and because of the potential for electrical transmission lines being collocated with pipelines.

  20. The methodologies and instruments of vehicle particulate emission measurement for current and future legislative regulations

    Science.gov (United States)

    Otsuki, Yoshinori; Nakamura, Hiroshi; Arai, Masataka; Xu, Min

    2015-09-01

    Since the health risks associated with fine particles whose aerodynamic diameters are smaller than 2.5 μm was first proven, regulations restricting particulate matter (PM) mass emissions from internal combustion engines have become increasingly severe. Accordingly, the gravimetric method of PM mass measurement is facing its lower limit of detection as the emissions from vehicles are further reduced. For example, the variation in the adsorption of gaseous components such as hydrocarbons from unburned fuel and lubricant oil and the presence of agglomerated particles, which are not directly generated in engine combustion but re-entrainment particulates from walls of sampling pipes, can cause uncertainty in measurement. The PM mass measurement systems and methodologies have been continuously refined in order to improve measurement accuracy. As an alternative metric, the particle measurement programme (PMP) within the United Nations Economic Commission for Europe (UNECE) developed a solid particle number measurement method in order to improve the sensitivity of particulate emission measurement from vehicles. Consequently, particle number (PN) limits were implemented into the regulations in Europe from 2011. Recently, portable emission measurement systems (PEMS) for in-use vehicle emission measurements are also attracting attention, currently in North America and Europe, and real-time PM mass and PN instruments are under evaluation.

  1. Leptin regulation of inward membrane currents, electrical activity and LH release in isolated bovine gonadotropes.

    Science.gov (United States)

    Domínguez-Mancera, Belisario; Barrientos-Morales, Manuel; Cervantes-Acosta, Patricia; Hernández-Beltrán, Antonio; Rodríguez-Andrade, Araceli; González-Ramírez, Ricardo; Monjaraz, Eduardo; Felix, Ricardo

    2017-09-09

    Leptin, a peptide hormone produced by adipocytes, is recognized as one of the signals involved in the onset of reproductive activity. The leptin receptor has been found in hypothalamic neurons and pituitary gonadotropes, suggesting that the hormone may act at both sites to stimulate the secretion of GnRH and consequently, FSH and LH. In response to a stimulus such as a hypothalamic secretagogue, gonadotropes respond with changes in electrical activity, intracellular Ca(2+) and hormone release. The main aim of this report was to investigate whether leptin promotes a change in the electrical and secretory activities of bovine gonadotropes. After 48 h of treatment with leptin (10 nM) significant changes in the action potential properties were observed in gonadotropes, which included an increase in amplitude, time-to-pike and post-hyperpolarization, as well as a decrease in firing threshold. Likewise, leptin induced a significant (∼1.3-fold) up-regulation of voltage-gated Na(+) channel current density, and a selective increase (∼2.1-fold) in Ca(2+) current density through high voltage-activated channels. Consistent with this, leptin enhanced GnRH-induced secretion of LH measured by ELISA. We suggest that leptin enhances membrane expression of voltage-gated Na(+) and Ca(2+) channels, which results in a modulation of the action potential properties and an increase in hormone release from gonadotropes. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Regulation of mature oil fields: a constitutional analysis; Regulacao de campos maduros de petroleo: uma analise a luz da Constituicao Federal de 1988

    Energy Technology Data Exchange (ETDEWEB)

    Siqueira, Mariana de; Xavier, Yanko Marcius de Alencar [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil)

    2008-07-01

    The oil activities in Brazil had been started in an intensive way by the years 30 and 40. During approximately 40 years only one agent had been executed the oil activities in this country: the PETROBRAS. Many of the fields explored in the past are nowadays in decline. These fields, not interesting for the majors, would be interesting for the small and medium enterprises. The present research analyses the mature oil fields and its regulation in Brazil, looking to the 'Constituicao Federal de 1988' and to the idea of social and economic development. (author)

  3. Federal Holidays

    Data.gov (United States)

    Office of Personnel Management — Federal law (5 U.S.C. 6103) establishes the following public holidays for Federal employees. Please note that most Federal employees work on a Monday through Friday...

  4. 48 CFR 29.203 - Other Federal tax exemptions.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Other Federal tax exemptions. 29.203 Section 29.203 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS TAXES Federal Excise Taxes 29.203 Other Federal tax exemptions....

  5. Interpretation of 40 CFR 52.21 Federal Regulations for the Prevention of Significant Air Quality Deterioration (PSD)

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database.

  6. Analysis of experience of legal regulation in the sphere of public administration of sanatorium providing of children in the Russian Federation

    Directory of Open Access Journals (Sweden)

    Kovalenko T.Yu.

    2014-03-01

    Full Text Available Motherhood and childhood are one of the main priorities of the government social policy for any country. The Ukrainian state, its President and government are keeping under scrutiny issues of improving quality of life and health of population, in particular, health of women and children. Continuing study of problems of Public Administration in the sphere of health resort services for children in Ukraine, in her previous scientific publications the author drew attention to insufficient scope of researches and weak grounds of theoretical justification of possible organizational changes in this sphere. This very fact stipulates the necessity to continue thorough scientific research and study, first of all, a positive experience of foreign countries as to implementing reforms in the sphere of health resort services for children. The share of separate factors of different nature, impacting indicators of public health depends on age, sex and individual-typological characteristics of a person. However, the greatest impact on a human health is made by his lifestyle that may be attributed to conditionally controlled process. In this case, it is appropriate to note that the controlled impact on lifestyle can be made both by internal factors (e.g., motivation, and external factors. One of the most powerful external factors of controlled impact on the public health is health resort provision. The experience of the Russian Federation in this area is extremely useful for the Ukrainian state, which is actively promoting the idea of the health system modernization in the domestic market as the area in need of such changes. Now, 1997 health resorts are operating in the Russian Federation, annually serving approximately 6 million people. The jurisdiction of the Ministry of Health and Social Development of the Russian Federation encompasses 51 health resort facilities (HRF providing a wide range of health-improving services. The laws, government regulations

  7. Electricity Transmission, Pipelines, and National Trails. An Analysis of Current and Potential Intersections on Federal Lands in the Eastern United States, Alaska, and Hawaii

    Energy Technology Data Exchange (ETDEWEB)

    Kuiper, James A; Krummel, John R; Hlava, Kevin J; Moore, H Robert; Orr, Andrew B; Schlueter, Scott O; Sullivan, Robert G; Zvolanek, Emily A

    2014-03-25

    As has been noted in many reports and publications, acquiring new or expanded rights-of-way for transmission is a challenging process, because numerous land use and land ownership constraints must be overcome to develop pathways suitable for energy transmission infrastructure. In the eastern U.S., more than twenty federally protected national trails (some of which are thousands of miles long, and cross many states) pose a potential obstacle to the development of new or expanded electricity transmission capacity. However, the scope of this potential problem is not well-documented, and there is no baseline information available that could allow all stakeholders to study routing scenarios that could mitigate impacts on national trails. This report, Electricity Transmission, Pipelines, and National Trails: An Analysis of Current and Potential Intersections on Federal Lands in the Eastern United States, was prepared by the Environmental Science Division of Argonne National Laboratory (Argonne). Argonne was tasked by DOE to analyze the “footprint” of the current network of National Historic and Scenic Trails and the electricity transmission system in the 37 eastern contiguous states, Alaska, and Hawaii; assess the extent to which national trails are affected by electrical transmission; and investigate the extent to which national trails and other sensitive land use types may be affected in the near future by planned transmission lines. Pipelines are secondary to transmission lines for analysis, but are also within the analysis scope in connection with the overall directives of Section 368 of the Energy Policy Act of 2005, and because of the potential for electrical transmission lines being collocated with pipelines. Based on Platts electrical transmission line data, a total of 101 existing intersections with national trails on federal land were found, and 20 proposed intersections. Transmission lines and pipelines are proposed in Alaska; however there are no

  8. Radiological protection regulation during spent nuclear fuel and radioactive waste management in the western branch of the Federal State Unitary Enterprise 'SevRAO'.

    Science.gov (United States)

    Simakov, A V; Sneve, M K; Abramov, Yu V; Kochetkov, O A; Smith, G M; Tsovianov, A G; Romanov, V V

    2008-12-01

    The site of temporary storage of spent nuclear fuel and radioactive waste, situated at Andreeva Bay in Northwest Russia, was developed in the 1960s, and it has carried out receipt and storage of fresh and spent nuclear fuel, and solid and liquid radioactive waste generated during the operation of nuclear submarines and nuclear-powered icebreakers. The site is now operated as the western branch of the Federal State Unitary Enterprise, SevRAO. In the course of operation over several decades, the containment barriers in the Spent Nuclear Fuel and Radioactive Waste storage facilities partially lost their containment effectiveness, so workshop facilities and parts of the site became contaminated with radioactive substances. This paper describes work being undertaken to provide an updated regulatory basis for the protection of workers during especially hazardous remediation activities, necessary because of the unusual radiation conditions at the site. It describes the results of recent survey work carried out by the Burnasyan Federal Medical Biophysical Centre, within a programme of regulatory cooperation between the Norwegian Radiation Protection Authority and the Federal Medical-Biological Agency of Russia. The survey work and subsequent analyses have contributed to the development of special regulations setting out radiological protection requirements for operations planned at the site. Within these requirements, and taking account of a variety of other factors, a continuing need arises for the implementation of optimisation of remediation at Andreeva Bay.

  9. Flexible Power Regulation and Current-limited Control of Grid-connected Inverter under Unbalanced Grid Voltage Faults

    DEFF Research Database (Denmark)

    Guo, Xiaoqiang; Liu, Wenzhao; Lu, Zhigang

    2017-01-01

    The grid-connected inverters may experience excessive current stress in case of unbalanced grid voltage Fault Ride Through (FRT), which significantly affects the reliability of the power supply system. In order to solve the problem, the inherent mechanisms of the excessive current phenomenon...... with the conventional FRT solutions are discussed. The quantitative analysis of three phase current peak values are conducted and a novel current-limited control strategy is proposed to achieve the flexible active and reactive power regulation and successful FRT in a safe current operation area with the aim...

  10. Current knowledge on the photoneuroendocrine regulation of reproduction in temperate fish species.

    Science.gov (United States)

    Migaud, H; Davie, A; Taylor, J F

    2010-01-01

    Seasonality is an important adaptive trait in temperate fish species as it entrains or regulates most physiological events such as reproductive cycle, growth profile, locomotor activity and key life-stage transitions. Photoperiod is undoubtedly one of the most predictable environmental signals that can be used by most living organisms including fishes in temperate areas. This said, however, understanding of how such a simple signal can dictate the time of gonadal recruitment and spawning, for example, is a complex task. Over the past few decades, many scientists attempted to unravel the roots of photoperiodic signalling in teleosts by investigating the role of melatonin in reproduction, but without great success. In fact, the hormone melatonin is recognized as the biological time-keeping hormone in fishes mainly due to the fact that it reflects the seasonal variation in daylength across the whole animal kingdom rather than the existence of direct evidences of its role in the entrainment of reproduction in fishes. Recently, however, some new studies clearly suggested that melatonin interacts with the reproductive cascade at a number of key steps such as through the dopaminergic system in the brain or the synchronization of the final oocyte maturation in the gonad. Interestingly, in the past few years, additional pathways have become apparent in the search for a fish photoneuroendocrine system including the clock-gene network and kisspeptin signalling and although research on these topics are still in their infancy, it is moving at great pace. This review thus aims to bring together the current knowledge on the photic control of reproduction mainly focusing on seasonal temperate fish species and shape the current working hypotheses supported by recent findings obtained in teleosts or based on knowledge gathered in mammalian and avian species. Four of the main potential regulatory systems (light perception, melatonin, clock genes and kisspeptin) in fish reproduction

  11. Regulating Current Rectification and Nanoparticle Transport Through a Salt Gradient in Bipolar Nanopores.

    Science.gov (United States)

    Lin, Chih-Yuan; Yeh, Li-Hsien; Hsu, Jyh-Ping; Tseng, Shiojenn

    2015-09-16

    Tuning of ion and nanoparticle transport is validated through applying a salt gradient in two types of nanopores: the inner wall of a nanopore has bipolar charges and its outer wall neutral (type I), and both the inner and outer walls of a nanopore have bipolar charges (type II). The ion current rectification (ICR) behavior of these nanopores can be regulated by an applied salt gradient: if it is small, the degree of ICR in type II nanopore is more significant than that in type I nanopore; a reversed trend is observed at a sufficiently large salt gradient. If the applied salt gradient and electric field have the same direction, type I nanopore exhibits two significant features that are not observed in type II nanopore: (i) a cation-rich concentration polarization field and an enhanced funneling electric field are present near the cathode side of the nanopore, and (ii) the magnitude of the axial electric field inside the nanopore is reduced. These features imply that applying a salt gradient to type I nanopore is capable of simultaneously enhancing the nanoparticle capture into the nanopore and reducing its translocation velocity inside, so that high sensing performance and resolution can be achieved.

  12. Socio-legal regulation of family relations: current status and prospects for development

    Directory of Open Access Journals (Sweden)

    Ludmila Saenko

    2013-04-01

    Full Text Available The crisis of the traditional family becomes important research methods and techniques of social regulation of family relations in contemporary reality. Particular attention is paid to the legal regulation of having the author's opinion the fundamental nature of the general system of social regulation, its value in the preservation of traditional moral family values.

  13. Thoughts on How to Regulate Behaviours: An Overview of the Current Debate

    Science.gov (United States)

    Etienne, Julien

    2013-01-01

    The article intends to present the debate on behaviour modification in the regulation studies literature, at a time of renewed interest among regulators for new ideas and strategies. As the financial crisis has led to the most public critique yet of the rational choice view of individuals that has informed regulation in the last few decades, other…

  14. 75 FR 34283 - Federal Acquisition Regulation; FAR Case 2009-025, Disclosure and Consistency of Cost Accounting...

    Science.gov (United States)

    2010-06-16

    ... Accounting Practices for Contracts Awarded to Foreign Concerns AGENCIES: Department of Defense (DoD), General... Regulation (FAR) to align the FAR with the revised Cost Accounting Standards (CAS) Board clause, Disclosure and Consistency of Cost Accounting Practices-Foreign Concerns. DATES: Effective Date: June 16,...

  15. 78 FR 18344 - Federal Acquisition Regulation; Submission for OMB Review; Buy American Act-Free Trade Agreements...

    Science.gov (United States)

    2013-03-26

    ... Regulation; Submission for OMB Review; Buy American Act--Free Trade Agreements--Israeli Trade Act Certificate... previously approved information collection requirement concerning the Buy American Act--Free Trade Agreements... comments identified by Information Collection 9000- 0130, Buy American Act--Free Trade Agreements--Israeli...

  16. 77 FR 52696 - Federal Acquisition Regulation; Information Collection; Drug-Free Workplace (FAR 52.223-6)

    Science.gov (United States)

    2012-08-30

    ... Regulation; Information Collection; Drug-Free Workplace (FAR 52.223-6) AGENCY: Department of Defense (DOD... approved information collection requirement concerning drug- free workplace. Public comments are... Information Collection 9000- 0101, Drug-Free Workplace, by any of the following methods:...

  17. 75 FR 13414 - Federal Acquisition Regulation; FAR Case 2008-012, Clarification of Submission of Cost or Pricing...

    Science.gov (United States)

    2010-03-19

    ... Regulation; FAR Case 2008-012, Clarification of Submission of Cost or Pricing Data on Non-Commercial... 814 required the harmonization of the thresholds for cost or pricing data. Specifically, section 814 required alignment of the threshold for cost or pricing data on non-commercial modifications of...

  18. 77 FR 467 - Notice of Tribal Consultation Meetings Regarding How the Current SACWIS Regulations Affect Tribes...

    Science.gov (United States)

    2012-01-05

    ... rules provide Federal Financial Participation (FFP) through a beneficial cost allocation methodology if... information systems that will meet their business needs. The Children's Bureau's (CB) Division of State... that will meet their business needs. We propose two such combined meetings via teleconferences to reach...

  19. Focused transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex modulates specific domains of self-regulation.

    Science.gov (United States)

    Pripfl, Jürgen; Lamm, Claus

    2015-02-01

    Recent neuroscience theories suggest that different kinds of self-regulation may share a common psychobiological mechanism. However, empirical evidence for a domain general self-regulation mechanism is scarce. The aim of this study was to investigate whether focused anodal transcranial direct current stimulation (tDCS), facilitating the activity of the dorsolateral prefrontal cortex (dlPFC), acts on a domain general self-regulation mechanism and thus modulates both affective and appetitive self-regulation. Twenty smokers participated in this within-subject sham controlled study. Effects of anodal left, anodal right and sham tDCS over the dlPFC on affective picture appraisal and nicotine craving-cue appraisal were assessed. Anodal right tDCS over the dlPFC reduced negative affect in emotion appraisal, but neither modulated regulation of positive emotion appraisal nor of craving appraisal. Anodal left stimulation did not induce any significant effects. The results of our study show that domain specific self-regulation networks are at work in the prefrontal cortex. Focused tDCS modulation of this specific self-regulation network could probably be used during the first phase of nicotine abstinence, during which negative affect might easily result in relapse. These findings have implications for neuroscience models of self-regulation and are of relevance for the development of brain stimulation based treatment methods for neuropsychiatric disorders associated with self-regulation deficits. Copyright © 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

  20. Chloride current in mammalian cardiac myocytes. Novel mechanism for autonomic regulation of action potential duration and resting membrane potential

    OpenAIRE

    1990-01-01

    The properties of the autonomically regulated chloride current (ICl) were studied in isolated guinea pig ventricular myocytes. This current was elicited upon exposure to isoproterenol (ISO) and reversed upon concurrent exposure to acetylcholine (ACh). ICl was time independent and exhibited outward rectification. The responses to ISO and ACh could be blocked by propranolol and atropine, respectively, and ICl was also elicited by forskolin, 8-bromoadenosine 3',5'-cyclic monophosphate, and 3-iso...

  1. Federal Air Pollutant Emission Regulations and Preliminary Estimates of Potential-to-Emit from Biorefineries, Pathway #2: Conversion of Lignocellulosic Biomass to Hydrocarbon Fuels: Fast Pyrolysis and Hydrotreating Bio-oil Pathway

    Energy Technology Data Exchange (ETDEWEB)

    Bhatt, Arpit [National Renewable Energy Lab. (NREL), Golden, CO (United States). Strategic Energy Analysis Center. Technology Systems and Sustainability Analysis Group; Zhang, Yimin [National Renewable Energy Lab. (NREL), Golden, CO (United States). Strategic Energy Analysis Center. Technology Systems and Sustainability Analysis Group; Heath, Garvin [National Renewable Energy Lab. (NREL), Golden, CO (United States). Strategic Energy Analysis Center. Technology Systems and Sustainability Analysis Group; Thomas, Mae [Eastern Research Group, Research Triangle Park, NC (United States); Renzaglia, Jason [Eastern Research Group, Research Triangle Park, NC (United States)

    2017-01-01

    Biorefineries are subject to environmental laws, including complex air quality regulations that aim to protect and improve the quality of the air. These regulations govern the amount of certain types of air pollutants that can be emitted from different types of emission sources. To determine which federal air emission regulations potentially apply to the fast pyrolysis biorefinery, we first identified the types of regulated air pollutants emitted to the ambient environment by the biorefinery or from specific equipment. Once the regulated air pollutants are identified, we review the applicability criteria of each federal air regulation to determine whether the fast pyrolysis biorefinery or specific equipment is subject to it. We then estimate the potential-to-emit of pollutants likely to be emitted from the fast pyrolysis biorefinery to understand the air permitting requirements.

  2. Federal Air Pollutant Emission Regulations and Preliminary Estimates of Potential-to-Emit from Biorefineries. Pathway #1: Dilute-Acid and Enzymatic Deconstruction of Biomass-to-Sugars and Biological Conversion of Sugars-to-Hydrocarbons

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yimin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bhatt, Arpit [National Renewable Energy Lab. (NREL), Golden, CO (United States); Heath, Garvin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Thomas, Mae [Eastern Research Group, Lexington, MA (United States); Renzaglia, Jason [Eastern Research Group, Lexington, MA (United States)

    2016-02-01

    Biorefineries are subject to environmental laws, including complex air quality regulations that aim to protect and improve the quality of the air. These regulations govern the amount of certain types of air pollutants that can be emitted from different types of emission sources. To determine which federal air emission regulations potentially apply to the sugars-to-hydrocarbon (HC) biorefinery, we first identified the types of regulated air pollutants emitted to the ambient environment by the biorefinery or from specific equipment. Once the regulated air pollutants are identified, we review the applicability criteria of each federal air regulation to determine whether the sugars-to-HC biorefinery or specific equipment is subject to it. We then estimate the potential-to-emit of pollutants likely to be emitted from the sugars-to-HC biorefinery to understand the air permitting requirements.

  3. 14 CFR Special Federal Aviation... - 2

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false 2 Federal Special Federal Aviation Regulation No. 50 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Special Federal Aviation Regulation No. 50-2...

  4. 14 CFR Special Federal Aviation... - 1

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false 1 Federal Special Federal Aviation Regulation No. 100 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: FLIGHT CREWMEMBERS OTHER THAN PILOTS Special Federal Aviation Regulation No...

  5. EPA's Interpretation of Regulations that Determine Pollutants Covered By Federal Prevention of Significant Deterioration (PSD) Permit Program

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  6. Current advances and strategies towards fully automated sample preparation for regulated LC-MS/MS bioanalysis.

    Science.gov (United States)

    Zheng, Naiyu; Jiang, Hao; Zeng, Jianing

    2014-09-01

    Robotic liquid handlers (RLHs) have been widely used in automated sample preparation for liquid chromatography-tandem mass spectrometry (LC-MS/MS) bioanalysis. Automated sample preparation for regulated bioanalysis offers significantly higher assay efficiency, better data quality and potential bioanalytical cost-savings. For RLHs that are used for regulated bioanalysis, there are additional requirements, including 21 CFR Part 11 compliance, software validation, system qualification, calibration verification and proper maintenance. This article reviews recent advances in automated sample preparation for regulated bioanalysis in the last 5 years. Specifically, it covers the following aspects: regulated bioanalysis requirements, recent advances in automation hardware and software development, sample extraction workflow simplification, strategies towards fully automated sample extraction, and best practices in automated sample preparation for regulated bioanalysis.

  7. The neuroendocrine regulation of food intake in fish: a review of current knowledge

    Directory of Open Access Journals (Sweden)

    Helene Volkoff

    2016-11-01

    Full Text Available Fish are the most diversified group of vertebrates and, although progress has been made in the past years, only relatively few fish species have been examined to date, with regards to the endocrine regulation of feeding in fish. In fish, as in mammals, feeding behavior is ultimately regulated by central effectors within feeding centers of the brain, which receive and process information from endocrine signals from both brain and peripheral tissues. Although basic endocrine mechanisms regulating feeding appear to be conserved among vertebrates, major physiological differences between fish and mammals and the diversity of fish, in particular in regard to feeding habits, digestive tract anatomy and physiology, suggest the existence of fish- and species-specific regulating mechanisms. This review provides an overview of hormones known to regulate food intake in fish, emphasizing on major hormones and the main fish groups studied to date.

  8. The Neuroendocrine Regulation of Food Intake in Fish: A Review of Current Knowledge.

    Science.gov (United States)

    Volkoff, Helene

    2016-01-01

    Fish are the most diversified group of vertebrates and, although progress has been made in the past years, only relatively few fish species have been examined to date, with regards to the endocrine regulation of feeding in fish. In fish, as in mammals, feeding behavior is ultimately regulated by central effectors within feeding centers of the brain, which receive and process information from endocrine signals from both brain and peripheral tissues. Although basic endocrine mechanisms regulating feeding appear to be conserved among vertebrates, major physiological differences between fish and mammals and the diversity of fish, in particular in regard to feeding habits, digestive tract anatomy and physiology, suggest the existence of fish- and species-specific regulating mechanisms. This review provides an overview of hormones known to regulate food intake in fish, emphasizing on major hormones and the main fish groups studied to date.

  9. Federalism Lives.

    Science.gov (United States)

    Howard, A. E. Dick

    1987-01-01

    Examines the concept of federalism in terms of its past history and its encouraging future. Calls for a revival of concern for federalism not simply as a convenient administrative arrangement but as a fundamental constitutional value. (BSR)

  10. Investigating Relationships among Pre-Service Science Teachers' Conceptual Knowledge of Electric Current, Motivational Beliefs and Self-Regulation

    Science.gov (United States)

    Inaltun, Hüseyin; Ates, Salih

    2015-01-01

    The purpose of this study is to examine relationships among pre-service science teachers' conceptual knowledge of electric current, motivational beliefs, and self-regulation. One hundred and twenty-seven students (female = 107, male = 20) enrolled in the science education program of a public university in Ankara participated the study. A concept…

  11. Investigating Relationships among Pre-Service Science Teachers' Conceptual Knowledge of Electric Current, Motivational Beliefs and Self-Regulation

    Science.gov (United States)

    Inaltun, Hüseyin; Ates, Salih

    2015-01-01

    The purpose of this study is to examine relationships among pre-service science teachers' conceptual knowledge of electric current, motivational beliefs, and self-regulation. One hundred and twenty-seven students (female = 107, male = 20) enrolled in the science education program of a public university in Ankara participated the study. A concept…

  12. Design and implementation of a bidirectional current-controlled voltage-regulated DC-DC switched-mode converter

    CSIR Research Space (South Africa)

    Coetzer, A

    2016-01-01

    Full Text Available The design and implementation of a bidirectional current-controlled voltage-regulated DC-DC converter is presented. The converter is required to connect a battery of electrochemical cells (the battery) to an asynchronous motor-drive unit via a...

  13. Regulation of voltage-gated sodium current by endogenous Src family kinases in cochlear spiral ganglion neurons in culture.

    Science.gov (United States)

    Feng, Shuang; Pflueger, Melissa; Lin, Shuang-Xiu; Groveman, Bradley R; Su, Jiping; Yu, Xian-Min

    2012-04-01

    Voltage-gated sodium (Na+) and potassium (K+)channels have been found to be regulated by Src family kinases(SFKs).However, how these channels are regulated by SFKs in cochlear spiral ganglion neurons (SGNs) remains unknown.Here, we report that altering the activity of endogenous SFKs modulated voltage-gated Na+, but not K+, currents recorded in embryonic SGNs in culture. Voltage-gated Na+ current was suppressed by inhibition of endogenous SFKs or just Src and potentiated by the activation of these enzymes. Detailed investigations showed that under basal conditions, SFK inhibitor application did not significantly affect the voltage-dependent activation, but shifted the steady-state inactivation curves of Na+ currents and delayed the recovery of Na+ currents from inactivation. Application of Src specific inhibitor, Src40–58,not only shifted the inactivation curve but also delayed the recovery of Na+ currents and moved the voltage-dependent activation curve towards the left. The pre-inhibition of SFKs occluded all the effects induced by Src40–58 application, except the left shift of the activation curve. The activation of SFKs did not change either steady-state inactivation or recovery of Na+ currents, but caused the left shift of the activation curve.SFK inhibitor application effectively prevented all the effects induced by SFK activation, suggesting that both the voltage-dependent activation and steady-state inactivation of Na+ current are subjects of SFK regulation. The different effects induced by activation versus inhibition of SFKs implied that under basal conditions, endogenously active and inactive SFKs might be differentially involved in the regulation of voltage-gated Na+ channels in SGNs.

  14. 21 CFR 210.2 - Applicability of current good manufacturing practice regulations.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Applicability of current good manufacturing... AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE IN MANUFACTURING, PROCESSING, PACKING, OR HOLDING OF DRUGS; GENERAL § 210.2 Applicability of current good...

  15. 21 CFR 210.1 - Status of current good manufacturing practice regulations.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Status of current good manufacturing practice... SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE IN MANUFACTURING, PROCESSING, PACKING, OR HOLDING OF DRUGS; GENERAL § 210.1 Status of current good manufacturing practice...

  16. China Disabled Persons' Federation

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    China Disabled Persons' Federation (CDPF), founded in Beijing in 1988, is a national organization of/for all persons with disabilities (PWDs) of different categories in China. Mr. Deng Pufang is currently the Chairman.

  17. Low-level radioactive waste disposal in the United States: An overview of current commercial regulations and concepts

    Energy Technology Data Exchange (ETDEWEB)

    Kennedy, W.E. Jr.

    1993-08-01

    Commercial low-level radioactive waste disposal in the United States is regulated by the US Nuclear Regulatory Commission (NRC) under 10 CFR 61 (1991). This regulation was issued in 1981 after a lengthy and thorough development process that considered the radionuclide concentrations and characteristics associated with commercial low-level radioactive waste streams; alternatives for waste classification; alternative technologies for low-level radioactive waste disposal; and data, modeling, and scenario analyses. The development process also included the publication of both draft and final environmental impact statements. The final regulation describes the general provisions; licenses; performance objectives; technical requirements for land disposal; financial assurances; participation by state governments and Indian tribes; and records, reports, tests, and inspections. This paper provides an overview of, and tutorial on, current commercial low-level radioactive waste disposal regulations in the United States.

  18. Selective regulation of current densities underlies spontaneous changes in the activity of cultured neurons.

    Science.gov (United States)

    Turrigiano, G; LeMasson, G; Marder, E

    1995-05-01

    We study the electrical activity patterns and the expression of conductances in adult stomatogastric ganglion (STG) neurons as a function of time in primary cell culture. When first plated in culture, these neurons had few active properties. After 1 d in culture they produced small action potentials that rapidly inactivated during maintained depolarization. After 2 d in culture they fired large action potentials tonically when depolarized, and their properties resembled very closely the properties of STG neurons pharmacologically isolated in the ganglion. After 3-4 d in culture, however, their electrical properties changed and they fired in bursts when depolarized. We characterized the currents expressed by these neurons in culture. They included two TTX-sensitive sodium currents, a calcium current, a delayed-rectifier-like current, a calcium-dependent potassium current, and two A-type currents. The changes in firing properties with time in culture were accompanied by an increase in inward and decrease in outward current densities. A single-compartment conductance-based model of an STG neuron was constructed by fitting the currents measured in the biological neurons. When the current densities in the model neuron were matched to those measured for the biological neurons in each activity state, the model neuron closely reproduced each state, indicating that the changes in current densities are sufficient to account for the changes in intrinsic properties. These data indicate that STG neurons isolated in culture change their intrinsic electrical properties by selectively adjusting the magnitudes of their ionic conductances.

  19. A Study of Approval Plans and the Government’s Ability to Contract for Them under the Federal Acquisition Regulation (FAR)

    Science.gov (United States)

    1989-12-01

    along with procedural methods for implementing approval plans under current Department of Defense regulations. NTFIS GRASA DTIC TAB0 Just Ifced1 By...with loshiba MAP 1988 Corporation or Kongsberg Vapenfabrikk.- OfferorS Representation 52.225-17027 Restriction on Contracting with Toshiba MAR 1988... Corporation or Kongsberg Vapenfabrikk 52.227-7031( P Data Requirements APR 1912 52-232-7007( P Progress Payments - Alternate I OCT 1916 52.233-100( P

  20. Methods for growth regulation of greenhouse produced ornamental pot- and bedding plants – a current review

    Directory of Open Access Journals (Sweden)

    Bergstrand Karl-Johan I.

    2017-06-01

    Full Text Available Chemical plant growth regulators (PGRs are used in the production of ornamental potted and bedding plants. Growth control is needed for maximizing production per unit area, reducing transportation costs and to obtain a desired visual quality. However, the use of PGRs is associated with toxicity risks to humans and the environment. In many countries the availability of PGRs is restricted as few substances are registered for use. A number of alternative methods have been suggested. The methods include genetic methods (breeding and crop cultivation practices such as fertigation, temperature and light management. A lot of research into “alternative” growth regulation was performed during the 1980-1990s, revealing several possible ways of using different climatic factors to optimize plant growth with respect to plant height. In recent years, the interest in climatic growth regulation has been resurrected, not least due to the coming phase-out of the plant growth regulator chlormequat chloride (CCC. Today, authorities in many countries are aiming towards reducing the use of agrochemicals. At the same time, there is a strong demand from consumers for products produced without chemicals. This article provides a broad overview of available methods for non-chemical growth control. It is concluded that a combination of plant breeding and management of temperature, fertigation and light management has the potential of replacing chemical growth regulators in the commercial production of ornamental pot- and bedding plants.

  1. Marketing of research institutes in view of current organizational and legal regulations

    Directory of Open Access Journals (Sweden)

    Anna Slotorsz

    2013-03-01

    Full Text Available The paper aims to describe in a synthetic way some issues related to the marketing activity of R&D organizations in view of legal acts regulating the functioning of the state owned R&D organizations. The authors have analyzed some regulations related to research institutes and their activities, regulations specifying criteria and procedures of granting of a scientific category to a R&D unit as well as principals of financing of the science and regulations related to the operations of certifying units. Basing on this analysis the authors have elaborated a set of marketing goals of the R&D organizations, a list of their stakeholders and of specific marketing tools both accessible in view of the rules and regulations in force and effective from the point of view of parametric evaluation of the R&D organizations. Among the analyzed tools there are the following: issues related to publications, organization of conferences, seminars and popularizing events, organization of education and training courses, internal policies related to intellectual property protection, internal policies related to technology transfer, membership in international organizations and applied quality policies.

  2. Process stabilization by peak current regulation in reactive high-power impulse magnetron sputtering of hafnium nitride

    Science.gov (United States)

    Shimizu, T.; Villamayor, M.; Lundin, D.; Helmersson, U.

    2016-02-01

    A simple and cost effective approach to stabilize the sputtering process in the transition zone during reactive high-power impulse magnetron sputtering (HiPIMS) is proposed. The method is based on real-time monitoring and control of the discharge current waveforms. To stabilize the process conditions at a given set point, a feedback control system was implemented that automatically regulates the pulse frequency, and thereby the average sputtering power, to maintain a constant maximum discharge current. In the present study, the variation of the pulse current waveforms over a wide range of reactive gas flows and pulse frequencies during a reactive HiPIMS process of Hf-N in an Ar-N2 atmosphere illustrates that the discharge current waveform is a an excellent indicator of the process conditions. Activating the reactive HiPIMS peak current regulation, stable process conditions were maintained when varying the N2 flow from 2.1 to 3.5 sccm by an automatic adjustment of the pulse frequency from 600 Hz to 1150 Hz and consequently an increase of the average power from 110 to 270 W. Hf-N films deposited using peak current regulation exhibited a stable stoichiometry, a nearly constant power-normalized deposition rate, and a polycrystalline cubic phase Hf-N with (1 1 1)-preferred orientation over the entire reactive gas flow range investigated. The physical reasons for the change in the current pulse waveform for different process conditions are discussed in some detail.

  3. The effect of federal fuel sulfur regulations on in-use fleets: on-road heavy-duty source apportionment.

    Science.gov (United States)

    Johnson, Jason P; Kittelson, David B; Watts, Winthrop F

    2009-07-15

    From 2002 to 2007 fuel sulfur content in the Minneapolis/St Paul area decreased from about 325 ppm S to vehicles were measured to be 9.1 +/- 6.6 x 10(15) and 3.2 +/- 2.8 x 10(15) particles/kg of fuel burned, in 2006 and 2007, respectively, a reduction of 65%. In an earlier study in 2002 particle number emissions for the in-use HD fleet were 4.2 +/- 0.6 x 10(15) particles/km compared to the current measurements of 2.8 +/- 2.1 x 10(15) and 9.9 +/- 8.7 x 10(14) particles/km in 2006 and 2007, respectively. The HD particle mass emission standard remained unchanged from 1994 through 2006 and few 2007 HD vehicles were on the road at the time of this study so the decreases in number observed emissions are more likely due to reductions in the sulfur content of the fuel than to changes in engine and aftertreatment design.

  4. The evolution, current status, and regulation of ostomy products in the United States.

    Science.gov (United States)

    Turnbull, G B

    2001-01-01

    In today's rapidly evolving health care environment in which quality, cost-effectiveness, and outcomes are among the most valued health care products, significant issues must be addressed regarding ostomy products and how persons with stomas use them. The lack of evidence-based data has a direct impact on the pocketbooks of many patients with ostomies in the United States and their quality of life. Regulators, accrediting agencies, and payers look to WOC nurses and other providers to provide a sound scientific base upon which they can develop standards and regulations that will improve the life of Americans with stomas.

  5. A compilation of current regulations, standards and guidelines in remote afterloading brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Tortorelli, J.P.; Simion, G.P.; Kozlowski, S.D. [Idaho National Engineering Lab., Idaho Falls, ID (United States)

    1994-10-01

    Over a dozen government and professional organizations in the United States and Europe have issued regulations and guidance concerning quality management in the practice of remote afterloading brachytherapy. Information from the publications of these organizations was collected and collated for this report. This report provides the brachytherapy licensee access to a broad field of quality management information in a single, topically organized document.

  6. 76 FR 19282 - Direct Investment Surveys: Alignment of Regulations With Current Practices

    Science.gov (United States)

    2011-04-07

    ... eliminated from the regulations are: a survey of foreign direct investment in the U.S. seafood industry (BE... Foreign Person BE-21, Survey of Foreign Direct Investment in U.S. Business Enterprises Engaged in the... established or acquired entity. The data had been used to measure the amount of new foreign direct......

  7. A small potassium current in AgRP/NPY neurons regulates feeding behavior and enery metabolism

    Science.gov (United States)

    Neurons that co-express agouti-related peptide (AgRP) and neuropeptide Y (NPY) are indispensable for normal feeding behavior. Firing activities of AgRP/NPY neurons are dynamically regulated by energy status and coordinate appropriate feeding behavior to meet nutritional demands. However, intrinsic m...

  8. Dissociation of the store-operated calcium current ICRAC and the Mg-nucleotide-regulated metal ion current MagNuM

    Science.gov (United States)

    Hermosura, Meredith C; Monteilh-Zoller, Mahealani K; Scharenberg, Andrew M; Penner, Reinhold; Fleig, Andrea

    2002-01-01

    Rat basophilic leukaemia cells (RBL-2H3-M1) were used to study the characteristics of the store-operated Ca2+ release-activated Ca2+ current (ICRAC) and the magnesium-nucleotide-regulated metal cation current (MagNuM) (which is conducted by the LTRPC7 channel). Pipette solutions containing 10 mm BAPTA and no added ATP induced both currents in the same cell, but the time to half-maximal activation for MagNuM was about two to three times slower than that of ICRAC. Differential suppression of ICRAC was achieved by buffering free [Ca2+]i to 90 nm and selective inhibition of MagNuM was accomplished by intracellular solutions containing 6 mm Mg.ATP, 1.2 mm free [Mg2+]i or 100 μm GTP-γ-S, allowing investigations on these currents in relative isolation. Removal of extracellular Ca2+ and Mg2+ caused both currents to be carried significantly by monovalent ions. In the absence or presence of free [Mg2+]i, ICRAC carried by monovalent ions inactivated more rapidly and more completely than MagNuM carried by monovalent ions. Since several studies have used divalent-free solutions on either side of the membrane to study selectivity and single-channel behaviour of ICRAC, these experimental conditions would have favoured the contribution of MagNuM to monovalent conductance and call for caution in interpreting results where both ICRAC and MagNuM are activated. PMID:11882677

  9. Voltage-gated K+ currents in mouse articular chondrocytes regulate membrane potential.

    Science.gov (United States)

    Clark, Robert B; Hatano, Noriyuki; Kondo, Colleen; Belke, Darrell D; Brown, Barry S; Kumar, Sanjay; Votta, Bartholomew J; Giles, Wayne R

    2010-01-01

    Membrane currents and resting potential of isolated primary mouse articular chondrocytes maintained in monolayer cell culture for 1-9 days were recorded using patch clamp methods. Quantitative RT-PCR showed that the most abundantly expressed transcript of voltage-gated K(+) channels was for K(V)1.6, and immunological methods confirmed the expression of K(V)1.6 α-subunit proteins. These chondrocytes expressed a large time- and potential-dependent, Ca(2+)-independent 'delayed rectifier' K(+) current. Steady-state activation was well-fit by a Boltzmann function with a threshold near -50 mV, and a half-activation potential of -34.5 mV. The current was 50% blocked by 1.48 mM tetraethylammonium, 0.66 mM 4-aminopyridine and 20.6 nM α-dendrotoxin. The current inactivated very slowly at membrane potentials in the range of the resting potential of the chondrocytes. Resting membrane potential of the chondrocytes at room temperature (19-21°C) and in 5 mM external K(+) was -46.4 ± 1.3 mV (mean ± s.e.m; n = 23), near the 'foot' of the activation curve of this K(+) current. Resting potential was depolarized by an average of 4.2 ± 0.8 mV by 25 mM TEA, which blocked about 95% of the K(+) current. At a membrane potential of -50 mV, the apparent time constant of inactivation (tau(in)) was 37.9 s, and the 'steady-state' current level was 19% of that at a holding potential of -90 mV; at -40 mV, tau(in) was 20.3 s, and 'steady-state' current was 5% of that at -90 mV. These results demonstrate that in these primary cultured, mouse articular chondrocytes steady-state activation of a voltage-gated K(+) current contributes to resting membrane potential. However, this current is also likely to have a significant physiological role in repolarizing the chondrocyte following depolarizing stimuli that might occur in conditions of membrane stretch. For example, activation of TRP('transient receptor potential') non-specific cation channels in these cells during cyclic loading and unloading

  10. Visinin-like neuronal calcium sensor proteins regulate the slow calcium-activated afterhyperpolarizing current in the rat cerebral cortex

    Science.gov (United States)

    Villalobos, Claudio; Andrade, Rodrigo

    2010-01-01

    Many neurons in the nervous systems express afterhyperpolarizations that are mediated by a slow calcium-activated potassium current. This current shapes neuronal firing and is inhibited by neuromodulators, suggesting an important role in the regulation of neuronal function. Surprisingly, very little is currently known about the molecular basis for this current or how it is gated by calcium. Recently, the neuronal calcium sensor protein hippocalcin was identified as a calcium sensor for the slow afterhyperpolarizing current in the hippocampus. However, while hippocalcin is very strongly expressed in the hippocampus, this protein shows a relatively restricted distribution in the brain. Furthermore, the genetic deletion of this protein only partly reduces the slow hyperpolarizing current in hippocampus. These considerations question whether hippocalcin can be the sole calcium sensor for the slow afterhyperpolarizing current. Here we use loss of function and overexpression strategies to show that hippocalcin functions as a calcium sensor for the slow afterhyperpolarizing current in the cerebral cortex, an area where hippocalcin is expressed at much lower levels than in hippocampus. In addition we show that neurocalcin δ, but not VILIP-2, can also act as a calcium sensor for the slow afterhyperpolarizing current. Finally we show that hippocalcin and neurocalcin δ both increase the calcium sensitivity of the afterhyperpolarizing current but do not alter its sensitivity to inhibition by carbachol acting through the Gαq-11-PLCβ signaling cascade. These results point to a general role for a subgroup of visinin-like neuronal calcium sensor proteins in the activation of the slow calcium-activated afterhyperpolarizing current. PMID:20980592

  11. A Low Input Current and Wide Conversion Ratio Buck Regulator with 75% Efficiency for High-Voltage Triboelectric Nanogenerators

    Science.gov (United States)

    Luo, Li-Chuan; Bao, De-Chun; Yu, Wu-Qi; Zhang, Zhao-Hua; Ren, Tian-Ling

    2016-01-01

    It is meaningful to research the Triboelectric Nanogenerators (TENG), which can create electricity anywhere and anytime. There are many researches on the structures and materials of TENG to explain the phenomenon that the maximum voltage is stable and the current is increasing. The output voltage of the TENG is high about 180-400 V, and the output current is small about 39 μA, which the electronic devices directly integration of TENG with Li-ion batteries will result in huge energy loss due to the ultrahigh TENG impedance. A novel interface circuit with the high-voltage buck regulator for TENG is introduced firstly in this paper. The interface circuit can transfer the output signal of the TENG into the signal fit to a lithium ion battery. Through the circuit of the buck regulator, the average output voltage is about 4.0 V and the average output current is about 1.12 mA. Further, the reliability and availability for the lithium ion battery and the circuit are discussed. The interface circuit is simulated using the Cadence software and verified through PCB experiment. The buck regulator can achieve 75% efficiency for the High-Voltage TENG. This will lead to a research hot and industrialization applications.

  12. Inward Rectifier K+ Currents Are Regulated by CaMKII in Endothelial Cells of Primarily Cultured Bovine Pulmonary Arteries.

    Directory of Open Access Journals (Sweden)

    Lihui Qu

    Full Text Available Endothelium lines the interior surface of vascular walls and regulates vascular tones. The endothelial cells sense and respond to chemical and mechanical stimuli in the circulation, and couple the stimulus signals to vascular smooth muscles, in which inward rectifier K+ currents (Kir play an important role. Here we applied several complementary strategies to determine the Kir subunit in primarily cultured pulmonary arterial endothelial cells (PAECs that was regulated by the Ca2+/calmodulin (CaM-dependent protein kinase II (CaMKII. In whole-cell voltage clamp, the Kir currents were sensitive to micromolar concentrations of extracellular Ba2+. In excised inside-out patches, an inward rectifier K+ current was observed with single-channel conductance 32.43 ± 0.45 pS and Popen 0.27 ± 0.04, which were consistent with known unitary conductance of Kir 2.1. RT-PCR and western blot results showed that expression of Kir 2.1 was significantly stronger than that of other subtypes in PAECs. Pharmacological analysis of the Kir currents demonstrated that insensitivity to intracellular ATP, pinacidil, glibenclamide, pH, GDP-β-S and choleratoxin suggested that currents weren't determined by KATP, Kir2.3, Kir2.4 and Kir3.x. The currents were strongly suppressed by exposure to CaMKII inhibitor W-7 and KN-62. The expression of Kir2.1 was inhibited by knocking down CaMKII. Consistently, vasodilation was suppressed by Ba2+, W-7 and KN-62 in isolated and perfused pulmonary arterial rings. These results suggest that the PAECs express an inward rectifier K+ current that is carried dominantly by Kir2.1, and this K+ channel appears to be targeted by CaMKII-dependent intracellular signaling systems.

  13. A review of the current geographic distribution of and debate surrounding electronic cigarette clean air regulations in the United States.

    Science.gov (United States)

    Kadowaki, Joy; Vuolo, Mike; Kelly, Brian C

    2015-01-01

    In this article, we present the results of a systematic review of state, county, and municipal restrictions on the use of electronic cigarettes (e-cigarettes) in public spaces within the United States, alongside an overview of the current legal landscape. The lack of federal guidance leaves lower-level jurisdictions to debate the merits of restrictions on use in public spaces without sufficient scientific research. As we show through a geographic assessment of restrictions, this has resulted in an inconsistent patchwork of e-cigarette use bans across the United States of varying degrees of coverage. Bans have emerged over time in a manner that suggests a "bottom up" diffusion of e-cigarette clean air policies. Ultimately, the lack of clinical and scientific knowledge on the risks and potential harm reduction benefits has led to precautionary policymaking, which often lacks grounding in empirical evidence and results in spatially uneven diffusion of policy.

  14. Implementation issues on the design of current loops based on resonant regulators for isolated microgrids

    DEFF Research Database (Denmark)

    Federico, de Bosio; Pastorelli, Michele; Antonio DeSouza Ribeiro, Luiz;

    2016-01-01

    This paper analyzes the influence of state feedback coupling between the capacitor voltage and inductor current in voltage source inverters (VSI) operating in stand-alone microgrids. A decoupling technique is proposed as an effective measure to enhance the dynamics. Further implementation issues ...

  15. Regulation of calcium currents and secretion by magnesium in crustacean peptidergic neurons.

    Science.gov (United States)

    Richmond, J E; Sher, E; Keller, R; Haylett, B; Reichwein, B; Cooke, I M

    1995-12-01

    The effect of varying the external Mg2+ concentration on Ca2+ currents through voltage-operated Ca2+ channels has been examined with the patch-clamp technique in acutely isolated neuronal somata from the X-organ-sinus gland (XOSG) of the crab, Cardisoma carnifex. Neurons from this neurosecretory system were selected for morphology associated with crustacean hyperglycemic hormone (CHH) content. In parallel, the effects of Mg2+ concentration on K(+)-evoked secretion of CHH from isolated, intact XOSGs have been assayed by ELISA. At physiological Ca2+ levels the high-voltage-activated Ca2+ currents were attenuated with increasing Mg2+ concentration, with 50% inhibition at approximately 75 mM. Mg2+ block was voltage-dependent, relief from block occurring with increasing depolarization. Thus, in 24 mM Mg2+ inhibition of the Ca2+ current was approximately 55% at -10 mV. Secretion of CHH varied almost linearly with the log of Mg2+ concentration; in 2.4 mM Mg2+ it was double that in 24 mM Mg2+ and almost completely inhibited in 100 mM. Thus, Mg2+ produces a parallel inhibition of Ca2+ currents and CHH secretion and may play a role as a physiological modulator of neuronal activity and secretion in the XOSG of these crabs.

  16. Soft regulations in pharmaceutical policy making : an overview of current approaches and their consequences

    NARCIS (Netherlands)

    Wettermark, B.; Godman, B.; Jacobsson, B.; Haaijer-Ruskamp, F.M.

    2009-01-01

    It is a challenge to improve public health within limited resources. Pharmaceutical policy making is a greater challenge due to conflicting interests between key stakeholder groups. This paper reviews current and future strategies to help improve the quality and efficiency of care, with special emph

  17. GABAA receptor β3 subunit expression regulates tonic current in developing striatopallidal medium spiny neurons

    Directory of Open Access Journals (Sweden)

    Megan eJanssen

    2011-07-01

    Full Text Available The striatum is a key structure for movement control, but the mechanisms that dictate the output of distinct subpopulations of medium spiny projection neurons (MSNs, striatonigral projecting and dopamine D1 receptor- (D1+ or striatopallidal projecting and dopamine D2 receptor- (D2+ expressing neurons, remains poorly understood. GABA-mediated tonic inhibition largely controls neuronal excitability and action potential firing rates, and we previously suggested with pharmacological analysis that the GABAA receptor β3 subunit plays a large role in the basal tonic current seen in D2+ MSNs from young mice (Ade et al, 2008; Janssen et al, 2009. In this study, we demonstrated the essential role of the β3 GABAA receptor subunit in mediating MSN tonic currents using conditional β3 subunit knock-out (β3f/fDrd2 mice. Cre-lox genetics were used to generate conditional knock-out animals where Cre recombinase was expressed under the D2 receptor (Drd2 promoter. We show that while the wild-type MSN tonic current pattern demonstrates a high degree of variability, tonic current patterns from β3f/fDrd2 mice are narrow, suggesting that the β3 subunit is essential to striatal MSN GABA-mediated tonic current. Our data also suggest that a distinct population of synaptic receptors upregulate due to β3 subunit removal. Further, deletion of this subunit significantly decreases the D2+ MSN excitability. These results offer insight for target mechanisms in Parkinson’s disease, where symptoms arise due to the imbalance in striatal D1+ and D2+ MSN excitability and output.

  18. CURRENT WAGE AND LABOR REGULATION PROBLEMS IN RUSSIAN RESTRAURANTS END HOTELS

    Directory of Open Access Journals (Sweden)

    E. Sh. Kachalova

    2012-01-01

    Full Text Available At present, considerable disproportions take place in Russia between organizational, regulatory, social and economic relations actually existing in restaurant and hotel business enterprises on one part and provisions of their legal law basic norms and regulations on the other part. Labor organization and normative practice improvement directions are proposed for enterprises of the branch. Economic essence of the “tipping” phenomenon is revealed. Measures aimed at elimination of overcoming wage rise rates in comparison with those of the labor productivity presently existing in the branch.

  19. Influence of electroosmotic flow on the ionic current rectification in a pH-regulated, conical nanopore.

    Science.gov (United States)

    Lin, Dong-Huei; Lin, Chih-Yuan; Tseng, Shiojenn; Hsu, Jyh-Ping

    2015-09-01

    The ionic current rectification (ICR) is studied theoretically by considering a pH-regulated, conical nanopore. In particular, the effect of electroosmotic flow (EOF), which was often neglected in previous studies, is investigated by solving a set of coupled Poisson, Nernst-Planck, and Navier-Stokes equations. The behaviors of ICR under various conditions are examined by varying solution pH, bulk ionic concentration, and applied electric potential bias. We show that the EOF effect is significant when the bulk ionic concentration is medium high, the pH is far away from the iso-electric point, and the electric potential bias is high. The percentage deviation in the current rectification ratio arising from neglecting the EOF effect can be on the order of 100%. In addition, the behavior of the current rectification ratio at a high pH taking account of EOF is different both qualitatively and quantitatively from that without taking account of EOF.

  20. Current concepts of IgE regulation and impact of genetic determinants.

    Science.gov (United States)

    Potaczek, D P; Kabesch, M

    2012-06-01

    Immunoglobulin E (IgE) mediated immune responses seem to be directed against parasites and neoplasms, but are best known for their involvement in allergies. The IgE network is tightly controlled at different levels as outlined in this review. Genetic determinants were suspected to influence IgE regulation and IgE levels considerably for many years. Linkage and candidate gene studies suggested a number of loci and genes to correlate with total serum IgE levels, and recently genome-wide association studies (GWAS) provided the power to identify genetic determinants for total serum IgE levels: 1q23 (FCER1A), 5q31 (RAD50, IL13, IL4), 12q13 (STAT6), 6p21.3 (HLA-DRB1) and 16p12 (IL4R, IL21R). In this review, we analyse the potential role of these GWAS hits in the IgE network and suggest mechanisms of how genes and genetic variants in these loci may influence IgE regulation.

  1. Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins.

    Science.gov (United States)

    Pitt, Geoffrey S; Lee, Seok-Yong

    2016-09-01

    In cardiac and skeletal myocytes, and in most neurons, the opening of voltage-gated Na(+) channels (NaV channels) triggers action potentials, a process that is regulated via the interactions of the channels' intercellular C-termini with auxiliary proteins and/or Ca(2+) . The molecular and structural details for how Ca(2+) and/or auxiliary proteins modulate NaV channel function, however, have eluded a concise mechanistic explanation and details have been shrouded for the last decade behind controversy about whether Ca(2+) acts directly upon the NaV channel or through interacting proteins, such as the Ca(2+) binding protein calmodulin (CaM). Here, we review recent advances in defining the structure of NaV intracellular C-termini and associated proteins such as CaM or fibroblast growth factor homologous factors (FHFs) to reveal new insights into how Ca(2+) affects NaV function, and how altered Ca(2+) -dependent or FHF-mediated regulation of NaV channels is perturbed in various disease states through mutations that disrupt CaM or FHF interaction.

  2. Contribution of presynaptic calcium-activated potassium currents to transmitter release regulation in cultured Xenopus nerve-muscle synapses.

    Science.gov (United States)

    Pattillo, J M; Yazejian, B; DiGregorio, D A; Vergara, J L; Grinnell, A D; Meriney, S D

    2001-01-01

    Using Xenopus nerve-muscle co-cultures, we have examined the contribution of calcium-activated potassium (K(Ca)) channels to the regulation of transmitter release evoked by single action potentials. The presynaptic varicosities that form on muscle cells in these cultures were studied directly using patch-clamp recording techniques. In these developing synapses, blockade of K(Ca) channels with iberiotoxin or charybdotoxin decreased transmitter release by an average of 35%. This effect would be expected to be caused by changes in the late phases of action potential repolarization. We hypothesize that these changes are due to a reduction in the driving force for calcium that is normally enhanced by the local hyperpolarization at the active zone caused by potassium current through the K(Ca) channels that co-localize with calcium channels. In support of this hypothesis, we have shown that when action potential waveforms were used as voltage-clamp commands to elicit calcium current in varicosities, peak calcium current was reduced only when these waveforms were broadened beginning when action potential repolarization was 20% complete. In contrast to peak calcium current, total calcium influx was consistently increased following action potential broadening. A model, based on previously reported properties of ion channels, faithfully reproduced predicted effects on action potential repolarization and calcium currents. From these data, we suggest that the large-conductance K(Ca) channels expressed at presynaptic varicosities regulate transmitter release magnitude during single action potentials by altering the rate of action potential repolarization, and thus the magnitude of peak calcium current.

  3. Federal government information handbook: formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the Federal Government. It contains a summary of the organization and responsibilities of agencies within the executive branch of the Federal government which may be relevant to FUSRAP activities; a brief summary of relevant Federal statutes and regulations; a description of the structure of the US Congress, identification of the officers, relevant committees and committee chairmen; a description of the Federal legislative process; a summary of legislation enacted and considered in the recently-adjourned 96th Congress; a description of the Federal budgetary process; a summary of the Carter Administration's comprehensive radioactive waste management program; and excerpts from the text of relevant federal statutes and regulations.

  4. Federal government information handbook: formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the Federal Government. It contains a summary of the organization and responsibilities of agencies within the executive branch of the Federal government which may be relevant to FUSRAP activities; a brief summary of relevant Federal statutes and regulations; a description of the structure of the US Congress, identification of the officers, relevant committees and committee chairmen; a description of the Federal legislative process; a summary of legislation enacted and considered in the recently-adjourned 96th Congress; a description of the Federal budgetary process; a summary of the Carter Administration's comprehensive radioactive waste management program; and excerpts from the text of relevant federal statutes and regulations.

  5. β-Secretase BACE1 regulates hippocampal and reconstituted M-currents in a β-subunit-like fashion.

    Science.gov (United States)

    Hessler, Sabine; Zheng, Fang; Hartmann, Stephanie; Rittger, Andrea; Lehnert, Sandra; Völkel, Meike; Nissen, Matthias; Edelmann, Elke; Saftig, Paul; Schwake, Michael; Huth, Tobias; Alzheimer, Christian

    2015-02-25

    The β-secretase BACE1 is widely known for its pivotal role in the amyloidogenic pathway leading to Alzheimer's disease, but how its action on transmembrane proteins other than the amyloid precursor protein affects the nervous system is only beginning to be understood. We report here that BACE1 regulates neuronal excitability through an unorthodox, nonenzymatic interaction with members of the KCNQ (Kv7) family that give rise to the M-current, a noninactivating potassium current with slow kinetics. In hippocampal neurons from BACE1(-/-) mice, loss of M-current enhanced neuronal excitability. We relate the diminished M-current to the previously reported epileptic phenotype of BACE1-deficient mice. In HEK293T cells, BACE1 amplified reconstituted M-currents, altered their voltage dependence, accelerated activation, and slowed deactivation. Biochemical evidence strongly suggested that BACE1 physically associates with channel proteins in a β-subunit-like fashion. Our results establish BACE1 as a physiologically essential constituent of regular M-current function and elucidate a striking new feature of how BACE1 impacts on neuronal activity in the intact and diseased brain. Copyright © 2015 the authors 0270-6474/15/353298-14$15.00/0.

  6. Modulation of inhibitory strength and kinetics facilitates regulation of persistent inward currents and motoneuron excitability following spinal cord injury.

    Science.gov (United States)

    Venugopal, Sharmila; Hamm, Thomas M; Crook, Sharon M; Jung, Ranu

    2011-11-01

    Spasticity is commonly observed after chronic spinal cord injury (SCI) and many other central nervous system disorders (e.g., multiple sclerosis, stroke). SCI-induced spasticity has been associated with motoneuron hyperexcitability partly due to enhanced activation of intrinsic persistent inward currents (PICs). Disrupted spinal inhibitory mechanisms also have been implicated. Altered inhibition can result from complex changes in the strength, kinetics, and reversal potential (E(Cl(-))) of γ-aminobutyric acid A (GABA(A)) and glycine receptor currents. Development of optimal therapeutic strategies requires an understanding of the impact of these interacting factors on motoneuron excitability. We employed computational methods to study the effects of conductance, kinetics, and E(Cl(-)) of a dendritic inhibition on PIC activation and motoneuron discharge. A two-compartment motoneuron with enhanced PICs characteristic of SCI and receiving recurrent inhibition from Renshaw cells was utilized in these simulations. This dendritic inhibition regulated PIC onset and offset and exerted its strongest effects at motoneuron recruitment and in the secondary range of the current-frequency relationship during PIC activation. Increasing inhibitory conductance compensated for moderate depolarizing shifts in E(Cl(-)) by limiting PIC activation and self-sustained firing. Furthermore, GABA(A) currents exerted greater control on PIC activation than glycinergic currents, an effect attributable to their slower kinetics. These results suggest that modulation of the strength and kinetics of GABA(A) currents could provide treatment strategies for uncontrollable spasms.

  7. ErbB receptors and PKC regulate PC12 neuronal-like differentiation and sodium current elicitation.

    Science.gov (United States)

    García, L; Castillo, C; Carballo, J; Rodríguez, Y; Forsyth, P; Medina, R; Martínez, J C; Longart, M

    2013-04-16

    Excitability, neurite outgrowth and their specification are very important features in the establishment of neuronal differentiation. We have studied a conditioned medium (CM) from sciatic nerve which is able to induce a neuronal-like differentiation of PC12 cells. Previously, we have demonstrated that supplementing this CM with a generic inhibitor (k252a), which mainly inhibits tropomyosin-related kinase receptors (Trk receptors) and protein kinase C (PKC), caused neurite elongation, sodium current induction and axon development. In the present work, we are showing that the enhancement of neurite length and induction of sodium currents induced by CM+k252a were prevented by ErbB receptor inhibition. Additionally, we demonstrated that specific inhibition of PKC produced a similar effect to that exerted by k252a in CM-treated cells, specifically by increasing the percentage of differentiated cells with long neurites and inducing sodium currents. Moreover, CM changed the mRNA levels for ErbB2 and ErbB3 increasing them 6- and 36-folds respectively compared to their control. The inclusion of k252a with CM changed the ErbB1, ErbB2 and ErbB3 mRNA proportions increasing those eight-, seven- and fivefolds respectively. From this point, it is clear that appropriate ErbB receptor levels and PKC inhibition are necessary to enhance the effect of the CM in inducing the neuronal-like differentiation of PC12 cells. In summary, we demonstrated the involvement of ErbB receptors in the regulation of neurite elongation and sodium current induction in PC12 cells and propose that these processes could be initiated by ErbB receptors followed by a fine regulation of PKC signaling. These findings might implicate a novel interplay between ErbB receptors and PKC in the regulation of these molecular mechanisms.

  8. A política de atenção primária à saúde no Brasil: notas sobre a regulação e o financiamento federal Primary health care policy in Brazil: notes on Federal regulation and funding

    Directory of Open Access Journals (Sweden)

    Ana Luisa Barros de Castro

    2010-04-01

    Full Text Available O artigo analisa a condução federal da política de atenção primária à saúde no Brasil de 2003 a 2008, considerando as funções de Estado na saúde de planejamento, regulação, financiamento e execução direta de serviços. A pesquisa compreendeu revisão bibliográfica, realização de entrevistas semi-estruturadas com atores-chave da política, análise documental, orçamentária e de bases de dados secundários. Observou-se redução na execução federal direta das ações e fragilidades no que diz respeito ao planejamento. A atuação federal se caracterizou principalmente pela regulação, baseada na emissão de portarias atreladas a mecanismos financeiros. No que concerne ao financiamento, houve discreto aumento da participação da atenção básica no orçamento federal, reajustes e criação de novos incentivos, alguns visando à eqüidade. Embora tenham ocorrido avanços no período, permanece o desafio de reconuração do modelo regulatório federal e a garantia de um aporte maior de recursos para este nível de atenção, a fim de que ocorra o efetivo fortalecimento da atenção primária no país.This article analyzes the Federal implementation of primary health care policy in Brazil from 2003 to 2008, considering the government functions of health planning, regulation, financing, and health services delivery. The methodology included literature and document review, interviews with key policy actors, budget analysis, and health database analysis. The analysis showed a reduction in direct Federal health services delivery and weaknesses in Federal planning. Federal performance mainly involved regulation, based on norms linked to financial mechanisms. As for funding, the results showed a slight increase in the share for primary care in the Federal budget, adjustments, and creation of new incentives, some aimed at equity. Although some progress occurred, a remaining challenge is to reconure the Federal regulatory model and

  9. 48 CFR 1329.203-70 - DOC Federal tax exemption.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false DOC Federal tax exemption. 1329.203-70 Section 1329.203-70 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS TAXES Federal Excise Taxes 1329.203-70 DOC Federal tax exemption. (a) The Office...

  10. 48 CFR 1329.203 - Other Federal tax exemptions.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Other Federal tax exemptions. 1329.203 Section 1329.203 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS TAXES Federal Excise Taxes 1329.203 Other Federal tax exemptions....

  11. Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies.

    Science.gov (United States)

    Magnuson, B A; Burdock, G A; Doull, J; Kroes, R M; Marsh, G M; Pariza, M W; Spencer, P S; Waddell, W J; Walker, R; Williams, G M

    2007-01-01

    Aspartame is a methyl ester of a dipeptide used as a synthetic nonnutritive sweetener in over 90 countries worldwide in over 6000 products. The purpose of this investigation was to review the scientific literature on the absorption and metabolism, the current consumption levels worldwide, the toxicology, and recent epidemiological studies on aspartame. Current use levels of aspartame, even by high users in special subgroups, remains well below the U.S. Food and Drug Administration and European Food Safety Authority established acceptable daily intake levels of 50 and 40 mg/kg bw/day, respectively. Consumption of large doses of aspartame in a single bolus dose will have an effect on some biochemical parameters, including plasma amino acid levels and brain neurotransmitter levels. The rise in plasma levels of phenylalanine and aspartic acid following administration of aspartame at doses less than or equal to 50 mg/kg bw do not exceed those observed postprandially. Acute, subacute and chronic toxicity studies with aspartame, and its decomposition products, conducted in mice, rats, hamsters and dogs have consistently found no adverse effect of aspartame with doses up to at least 4000 mg/kg bw/day. Critical review of all carcinogenicity studies conducted on aspartame found no credible evidence that aspartame is carcinogenic. The data from the extensive investigations into the possibility of neurotoxic effects of aspartame, in general, do not support the hypothesis that aspartame in the human diet will affect nervous system function, learning or behavior. Epidemiological studies on aspartame include several case-control studies and one well-conducted prospective epidemiological study with a large cohort, in which the consumption of aspartame was measured. The studies provide no evidence to support an association between aspartame and cancer in any tissue. The weight of existing evidence is that aspartame is safe at current levels of consumption as a nonnutritive

  12. Inner Current Loop Analysis and Design Based on Resonant Regulators for Isolated Microgrids

    DEFF Research Database (Denmark)

    Federico, de Bosio; de Sousa Ribeiro, Luiz Antonio; Soares Lima, Marcel

    2015-01-01

    coupling in the design of proportional resonant controllers for these inner loops in voltage source inverters operating in islanded microgrids. It is also shown that the state feedback coupling has an important effect in the performance of the control loops by increasing the steady-state error......Inner current and voltage loops are fundamental in achieving good performance of microgrids based on power electronics voltage source inverters. The analysis and design of these loops are essential for the adequate operation of these systems. This paper investigates the effect of state feedback....... A comparison between different types of proportional+resonant controllers is done. Experimental results verify the theoretical assumptions done....

  13. 14 CFR Special Federal Aviation... - Process for Requesting Waiver of Mandatory Separation Age for a Federal Aviation Administration...

    Science.gov (United States)

    2010-01-01

    ... Separation Age for a Federal Aviation Administration Air Traffic Control Specialist In Flight Service... Federal Special Federal Aviation Regulation No. 103 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION..., SFAR 103 Special Federal Aviation Regulation No. 103—Process for Requesting Waiver of Mandatory...

  14. Exploring the structural requirements for jasmonates and related compounds as novel plant growth regulators: a current computational perspective.

    Science.gov (United States)

    Chen, Ke-Xian; Li, Zu-Guang

    2009-11-01

    Jasmonates and related compounds have been highlighted recently in the field of plant physiology and plant molecular biology due to their significant regulatory roles in the signaling pathway for the diverse aspects of plant development and survival. Though a considerable amount of studies concerning their biological effects in different plants have been widely reported, the molecular details of the signaling mechanism are still poorly understood. This review sheds new light on the structural requirements for the bioactivity/property of jasmonic acid derivatives in current computational perspective, which differs from previous research that mainly focus on their biological evaluation, gene and metabolic regulation and the enzymes in their biosynthesis. The computational results may contribute to further understanding the mechanism of drug-receptor interactions in their signaling pathway and designing novel plant growth regulators as high effective ecological pesticides.

  15. Recent experimental results of effects of perfluoroalkyl substances in laboratory animals - Relation to current regulations and guidance values.

    Science.gov (United States)

    Lilienthal, Hellmuth; Dieter, Hermann H; Hölzer, Jürgen; Wilhelm, Michael

    2017-03-02

    The detection of perfluoroalkyl substances (PFAS) in surface and drinking water from various countries raised the attention to the presence of these chemicals in environmental probes and led to several regulatory actions to limit exposure in human beings. There was particular concern about perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), due to their former wide-spread use. Recently, several institutions published revisions of former regulatory or recommended maximum concentrations in drinking water and food, which are markedly lower than the former values. The present short overview describes the current regulations for PFAS and compares them with the outcome of several experimental studies in laboratory animals at low-level exposure to PFOA and PFOS. In addition, regulations for short-chain PFAS are presented which, due to lack of toxicological information, are evaluated according to the concepts of Threshold of Toxicological Concern (TTC) or the Health-related Indication Values (HRIV).

  16. Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives

    Directory of Open Access Journals (Sweden)

    Schmidt BZ

    2016-09-01

    Full Text Available Béla Z Schmidt,1 Jérémy B Haaf,2 Teresinha Leal,2 Sabrina Noel,2 1Stem Cell Biology and Embryology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, 2Louvain Center for Toxicology and Applied Pharmacology, Université Catholique de Louvain, Brussels, Belgium Abstract: Mutations of the CFTR gene cause cystic fibrosis (CF, the most common recessive monogenic disease worldwide. These mutations alter the synthesis, processing, function, or half-life of CFTR, the main chloride channel expressed in the apical membrane of epithelial cells in the airway, intestine, pancreas, and reproductive tract. Lung disease is the most critical manifestation of CF. It is characterized by airway obstruction, infection, and inflammation that lead to fatal tissue destruction. In spite of great advances in early and multidisciplinary medical care, and in our understanding of the pathophysiology, CF is still considerably reducing the life expectancy of patients. This review highlights the current development in pharmacological modulators of CFTR, which aim at rescuing the expression and/or function of mutated CFTR. While only Kalydeco® and Orkambi® are currently available to patients, many other families of CFTR modulators are undergoing preclinical and clinical investigations. Drug repositioning and personalized medicine are particularly detailed in this review as they represent the most promising strategies for restoring CFTR function in CF. Keywords: high-throughput screening, drug repositioning, personalized medicine, precision medicine, potentiators, correctors

  17. Federal Lands

    Data.gov (United States)

    Department of Homeland Security — This map layer consists of federally owned or administered lands of theUnited States, Puerto Rico, and the U.S. Virgin Islands. Only areas of 640 acres or more are...

  18. 48 CFR 970.2902-3 - Other Federal tax exemptions.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Other Federal tax exemptions. 970.2902-3 Section 970.2902-3 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Taxes 970.2902-3 Other Federal tax...

  19. Regulation of zebrafish sleep and arousal states: current and prospective approaches

    Directory of Open Access Journals (Sweden)

    Cindy N Chiu

    2013-04-01

    Full Text Available Every day, we shift among various states of sleep and arousal to meet the many demands of our bodies and environment. A central puzzle in neurobiology is how the brain controls these behavioral states, which are essential to an animal’s well-being and survival. Mammalian models have predominated sleep and arousal research, although in the past decade, invertebrate models have made significant contributions to our understanding of the genetic underpinnings of behavioral states. More recently, the zebrafish has emerged as a promising model system for sleep and arousal research. Here we review experimental evidence that the zebrafish, a diurnal vertebrate, exhibits fundamental behavioral and neurochemical characteristics of mammalian sleep and arousal. We also propose how specific advantages of the zebrafish can be harnessed to advance the field. These include tractable genetics to identify and manipulate molecular and cellular regulators of behavioral states, optical transparency to facilitate in vivo observation of neural structure and function, and amenability to high-throughput drug screens to discover novel therapies for neurological disorders.

  20. FINANCIAL MEGAREGULATION IN THE RUSSIAN FEDERATION

    Directory of Open Access Journals (Sweden)

    Ochakovsky V. A.

    2014-01-01

    Full Text Available 2013 became year of changes for a financial system of the Russian Federation. On the basis of the Central bank of the Russian Federation there the financial mega-regulator began to work

  1. A 3 A sink/source current fast transient response low-dropout Gm driven linear regulator*

    Institute of Scientific and Technical Information of China (English)

    Chu Xiuqin; Li Qingwei; Lai Xinquan; Yuan Bing; LiYanming; Zhao Yongrui

    2011-01-01

    A 3 A sink/source Gm-driven CMOS low-dropout regulator (LDO), specially designed for low input voltage and low cost, is presented by utilizing the structure of a current mirror Gm (transconductance) driving technique, which provides high stability as well as a fast load transient response. The proposed LDO was fabricated by a 0.5μm standard CMOS process, and the die size is as small as 1.0 mm2. The proposed LDO dissipates 220 μA of quiescent current in no-load conditions and is able to deliver up to 3 A of load current. The measured results show that the output voltage can be resumed within 2 μs with a less than l mV overshoot and undershoot in the output current step from -1.8 to 1.8 A with a 0.1μs rising and falling time at three 10μF ceramic capacitors.

  2. 49 CFR Attachment 3 - Offices Within Federal Agencies and Federal-State Agencies for Information Regarding the Agencies...

    Science.gov (United States)

    2010-10-01

    ... Attachment 3 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC.... Attachment 3—Offices Within Federal Agencies and Federal-State Agencies for Information Regarding...

  3. 75 FR 8239 - Federal Home Loan Bank Housing Associates, Core Mission Activities and Standby Letters of Credit

    Science.gov (United States)

    2010-02-24

    ... 2590-AA33 Federal Home Loan Bank Housing Associates, Core Mission Activities and Standby Letters of... Home Loan Bank (Bank) housing associates, the Banks' core mission activities, and Bank issuance of... collection contained in the current Federal Home Loan Bank Housing Associates regulation, has been...

  4. CURRENT SHEET REGULATION OF SOLAR NEAR-RELATIVISTIC ELECTRON INJECTION HISTORIES

    Energy Technology Data Exchange (ETDEWEB)

    Agueda, N.; Sanahuja, B. [Departament d' Astronomia i Meteorologia, Institut de Ciencies del Cosmos, Universitat de Barcelona (Spain); Vainio, R. [Department of Physics, University of Helsinki (Finland); Dalla, S. [Jeremiah Horrocks Institute, University of Central Lancashire (United Kingdom); Lario, D. [Applied Physics Laboratory, Johns Hopkins University (United States)

    2013-03-10

    We present a sample of three large near-relativistic (>50 keV) electron events observed in 2001 by both the ACE and the Ulysses spacecraft, when Ulysses was at high-northern latitudes (>60 Degree-Sign ) and close to 2 AU. Despite the large latitudinal distance between the two spacecraft, electrons injected near the Sun reached both heliospheric locations. All three events were associated with large solar flares, strong decametric type II radio bursts and accompanied by wide (>212 Degree-Sign ) and fast (>1400 km s{sup -1}) coronal mass ejections (CMEs). We use advanced interplanetary transport simulations and make use of the directional intensities observed in situ by the spacecraft to infer the electron injection profile close to the Sun and the interplanetary transport conditions at both low and high latitudes. For the three selected events, we find similar interplanetary transport conditions at different heliolatitudes for a given event, with values of the mean free path ranging from 0.04 AU to 0.27 AU. We find differences in the injection profiles inferred for each spacecraft. We investigate the role that sector boundaries of the heliospheric current sheet (HCS) have on determining the characteristics of the electron injection profiles. Extended injection profiles, associated with coronal shocks, are found if the magnetic footpoints of the spacecraft lay in the same magnetic sector as the associated flare, while intermittent sparse injection episodes appear when the spacecraft footpoints are in the opposite sector or a wrap in the HCS bounded the CME structure.

  5. [Role of calcineurin in down-regulation of left ventricular transmural voltage- dependent K(+) currents in mice with heart failure].

    Science.gov (United States)

    Shi, Chen-Xia; Dong, Fang; Chang, Yan-Chao; Wang, Xiao-Feng; Xu, Yan-Fang

    2015-08-25

    The aim of the present study was to investigate the role of calcineurin in the down-regulation of left ventricular transmural voltage-dependent K(+) currents in heart failure. Transverse aorta was banded by using microsurgical techniques to create mouse heart failure model. Sham-operated (Sham) or aorta banded (Band) mice were randomized to receive calcineurin inhibitor cyclosporine A (CsA) or vehicle. The densities and kinetic properties of voltage-dependent K(+) currents, as well as action potential (AP), of left ventricular subendocardial (Endo) and subepicardial (Epi) myocytes were determined by using whole-cell patch-clamp technique. The results showed that calcineurin activity was significant higher in Endo myocytes than that in Epi ones in all the groups. Compared with Sham group, Band mice showed significantly increased calcineurin activity both in Endo and Epi myocytes. CsA significantly reduced calcineurin activity in Band mice. CsA treatment in Band mice partially reversed the down-regulation of Ito density, completely reversed the down-regulation of IK,slow density both in Endo and Epi myocytes, and Iss density in Endo myocytes. In addition, CsA treatment in Band mice partially antagonized the prolongation of action potential duration (APD), and APD at 50% (APD50) and 90% repolarization (APD90) were significantly reduced. Because of non-parallel shortening of APD in Endo and Epi myocytes, the ratio of Endo/Epi APD90 was reduced from 4.8:1 in Band mice to 2.6:1 in CsA-treated mice, which was close to that in Sham mice. The results suggest that non-parallel activation of calcineurin in Endo and Epi myocytes contributes to the down-regulation of transmural voltage-dependent K(+) currents and the amplification of transmural dispersion of repolarization (TDR) in left ventricular failure hearts. Inhibition of calcineurin may be a potential new therapeutic strategy to prevent and cure arrhythmias and sudden death in heart failure.

  6. Ultralow-quiescent-current and wide-load-range low-dropout linear regulator with self-biasing technique for micropower battery management

    Science.gov (United States)

    Ozaki, Toshihiro; Hirose, Tetsuya; Asano, Hiroki; Kuroki, Nobutaka; Numa, Masahiro

    2017-04-01

    In this paper, we present a 151 nA quiescent and 6.8 mA maximum-output-current low-dropout (LDO) linear regulator for micropower battery management. The LDO regulator employs self-biasing and multiple-stacked cascode techniques to achieve efficient, accurate, and high-voltage-input-tolerant operation. Measurement results demonstrated that the proposed LDO regulator operates with an ultralow quiescent current of 151 nA. The maximum output currents with a 4.16 V output were 1.0 and 6.8 mA when the input voltages were 4.25 and 5.0 V, respectively.

  7. Fiscal Federalism

    DEFF Research Database (Denmark)

    Feng, Xingyuan; Ljungwall, Christer; Guo, Sujian

    2013-01-01

    in the Western literature? Second, are there any problems with existing principles of fiscal federalism and, if so, how to refine them? Third, how are refined principles relevant to the Chinese case and what policies should the Chinese government pursue in the future? Based on an in-depth and critical review...... relations is not without controversy. This paper aims to make a theoretical contribution to the ongoing debate on ‘fiscal federalism’ by addressing crucial questions regarding China's central–local fiscal relations: first, to what extent do Chinese central–local fiscal relations conform to fiscal federalism...

  8. Role of calcium mobilization in the regulation of spontaneous transient outward currents in porcine coronary artery myocytes

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The purpose of the present study was to further study the characteristics and regulation of spontaneous transient outward currents (STOCs) in freshly isolated porcine coronary artery smooth muscle cells (ASMCs). STOCs were recorded using the perforated whole-cell patch-clamp configuration. STOCs were voltage-dependent and superimposed stochastically onto whole-cell Ca2+-activated-K+ (BKCa) currents. Charybdotoxin (ChTX, 200 nmol/L), a selective blocker of BKCa channels, completely inhibited STOCs within 10 min. STOCs activity was greatly suppressed when extracellular Ca2+ concentration decreased from 1.8 mmol/L to 200 nmol/L, further removal of Ca2+ abolished STOCs activity. Ca2+ ionophore A23187 (10 μmol/L) increased STOCs activity significantly. Verapamil (20 μmol/L) and CdCl2 (200 μmol/L), two kinds of organic L-type voltage-dependent Ca2+ channels (L-VDCCs) antagonists, had little effect on STOCs. In addition, the ryanodine receptors (RyRs) agonist caffeine (5 mmol/L) significantly activated STOCs. Application of ryanodine (50 μmol/L) to block RyRs abolished STOCs, subsequent washout of ryanodine or application of caffeine failed to reproduce STOCs activity. Inhibition of inositol 1,4,5-trisphosphate receptors (IP3Rs) by 2APB (40 μmol/L) greatly suppressed the activity of STOCs, application of caffeine (5 mmol/L) in the presence of 2APB caused a burst of outward currents followed by inhibition of STOCs. These results suggest that STOCs in porcine coronary ASMCs are mediated by BKCa channels. Extracellular Ca2+ is essential for STOCs activity, while Ca2+ entry through L-VDCCs has little effect on STOCs. Intracellular Ca2+ release induced by RyRs is responsible for the regulation of STOCs, whereas IP3Rs might also be involved.

  9. PingFederate

    Data.gov (United States)

    US Agency for International Development — PingFederate Server provides Identity Federation and Single Sign On Capabilities. Federated identity management (or identity federation) enables enterprises to...

  10. Single-channel and whole-cell recordings of mitogen-regulated inward currents in human cloned helper T lymphocytes.

    Science.gov (United States)

    Kuno, M; Goronzy, J; Weyand, C M; Gardner, P

    Cytoplasmic free Ca2+ [( Ca2+]i) appears to be an important signal for DNA synthesis in early stages of lymphocyte activation. In spite of many experimental studies which employ fluorescent Ca2+ indicator dye to demonstrate an early increase of [Ca2+]i in T-lymphocytes after stimulation with lectins, specific antigens, and monoclonal antibodies to T-lymphocyte receptors, the mechanism responsible for the rise of [Ca2+]i is unknown. We have used the extracellular patch clamp technique to investigate this mechanism. Unitary inward currents, mediated by Ca2+ or Ba2+, were recorded in the membrane of T-lymphocytes. The inward current channel was characterized by a conductance of 7 pS and extrapolated reversal potential (Erev) 110 mV positive to resting potential (Vr). While gating kinetic parameters were not affected by membrane potential changes, the probability of channel opening markedly increased upon activation of the T-lymphocyte by the mitogenic lectin, phytohaemagglutinin (PHA). PHA also evoked a cadmium-sensitive, inward Ba2+ current on whole-cell clamp. We suggest that this mitogen-regulated channel introduces Ca2+ into the cytoplasm upon activation and represents a new class of voltage-independent Ca2+ channels.

  11. Control of the light-regulated current in rod photoreceptors by cyclic GMP, calcium, and l-cis-diltiazem.

    Science.gov (United States)

    Stern, J H; Kaupp, U B; MacLeish, P R

    1986-02-01

    The effect of calcium ions on the cGMP-activated current of outer segment membrane was examined by the excised-patch technique. Changes in the extracellular calcium concentration had marked effects on the cGMP-activated current, while changes in intracellular calcium concentration were ineffective. Changes in calcium concentration in the absence of cGMP had little, if any, effect on membrane conductance. These results suggest that both intracellular cGMP and extracellular calcium can directly affect the conductance underlying the light response in rod cells. The pharmacological agent l-cis-diltiazem reversibly inhibited the cGMP-activated current when applied to the intracellular side of an excised patch. When superfused over intact rod cells, l-cis-diltiazem reversibly blocked much of the normal light response. The isomer, d-cis-diltiazem, did not significantly affect either patches or intact rod cells. Thus, the light-regulated conductance has binding sites for both calcium and cGMP that may interact during the normal light response in rod cells and a site specific for l-cis-diltiazem that can be used to identify and further study the conductance mechanism.

  12. Creeping Federalization

    DEFF Research Database (Denmark)

    Sweeney, Richard J.

    2003-01-01

    that make taxharmonization difficult to impose. Other types of harmonization have a less clear-cut costbenefitanalysis. A federal commercial code that is uniform across member states reducestransaction and information costs, compared to leaving important code issues to memberstates; further, many states may...

  13. Review of the Federal Mining Law. [German Federal Republic

    Energy Technology Data Exchange (ETDEWEB)

    Weller, H.

    1981-01-01

    The Federal Mining Law is a codification of mining law in the Federal Republic of Germany. It contains 178 paragraphs covering all aspects of prospecting and mining of mineral raw materials and related activities. The new law is to replace the former regional mining laws as well as most of the former Federal and regional regulations. All in all, 104 laws and regulations are repealed in sections 174 and 175. Basic principles of the former mining laws have been adhered to, e.g. mineral reserves do not come under the proprietory rights of the land owner, preventive monitoring of operations by means of operation plans, cession of territory under mining law, and the regulations concerning mining and land ownership. However, there are new details in the Federal Mining Law, in particular with regard to concessions and mining damage; this is reflected in a more complicated legal language.

  14. Mechanism for Muscarinic Inhibitory Regulation of the L-type Ca2 + Current in Cardiac Ventricular Myocytes

    Institute of Scientific and Technical Information of China (English)

    蒋彬; 杨向军; 惠杰; 蒋廷波; 宋建平; 刘志华

    2004-01-01

    @@ Objective The autonomic nervous system plays a key role in regulating cardiac function by modifying heart rate, contractility and impulse. The parasympathetic neurotransmitter acetyl-choline and muscarinic agonist carbachol (Cch) inhibit excitation-contraction coupling in cardiac ventricular myocytes. Muscarinic agonists suppress adenylyl cyclase (AC) acitivity and,by reducing activation of the cAMP/protein kinase A (PKA)cascade, inhibit the L-type Ca2+ current (ICa(L) ). They also increase the content of cGMP by stimulating guanylyl cyclase (GC) activity. The role of nitric oxide (NO)/cGMP in muscarinic inhibition has undergone considerable scrutiny. The role of the NO/cGMP pathway in the inhibition of ICa(L) by Cch was examined in guinea-pig ventricular myocytes.

  15. [National system of protection against electromagnetic fields 0 Hz-300 GHz in the light of current legal regulations].

    Science.gov (United States)

    Aniołczyk, Halina

    2006-01-01

    Exposure to electromagnetic fields (EMF) occurs when man is exposed to the effect of electric, magnetic and electromagnetic fields and contact currents different from those resulting from physiological processes in the organism or other natural phenomena. In Poland, the system of protection against EMF has been functioning for over 35 years. In 2001, when the Minister of Labor and Social Policy issued the regulation introducing the maximum admissible intensities (MAI) for electromagnetic fields and radiation within the range of 0 Hz-300 GHz, the system was directed mainly towards evaluation of exposure to EMF occurring in the occupational environment. The system is linked via MAI values with human protection in the natural environment. In this paper, the background, principles and the range of the national system of protection against EMF and its monitoring are presented. The project of implementation of EU directives, following Poland's accession to the European Union is also discussed.

  16. Radiation and Reason Why radiation at modest dose rates is quite harmless and current radiation safety regulations are flawed

    CERN Document Server

    CERN. Geneva

    2013-01-01

    Data on the impact of ionising radiation on life are examined in the light of evolutionary biology. This comparison confirms that fear of nuclear radiation is not justified by science itself; rather it originates in a failure of public trust in nuclear science, a relic of the international politics of the Cold War era. Current ionisation safety regulations appease this fear but without scientific support and they need fundamental reformulation. This should change the reaction to accidents like Fukushima, the cost of nuclear energy and the application of nuclear technology to the supply of food and fresh water. Such a boost to the world economy would require that more citizens study and appreciate the science involved – and then tell others -- not as much fun as the Higgs, perhaps, but no less important! www.radiationandreason.com

  17. Distributed Nonlinear Control with Event-Triggered Communication to Achieve Current-Sharing and Voltage Regulation in DC Microgrids

    DEFF Research Database (Denmark)

    Han, Renke; Meng, Lexuan; Guerrero, Josep M.

    2017-01-01

    A distributed nonlinear controller is presented to achieve both accurate current-sharing and voltage regulation simultaneously in dc microgrids considering different line impedances’ effects among converters. Then, an improved event-triggered principle for the controller is introduced through...... combining the state-dependent tolerance with a nonnegative offset. In order to design the event-triggered principle and guarantee the global stability, a generalized dc microgrid model is proposed and proven to be positive definite, based on which Lyapunov-based approach is applied. Furthermore, considering...... the effects from constant power loads, the damping performance of proposed controller is further improved and compared with the traditional V-I droop controller. The proposed event-triggered-based communication strategy can considerably reduce the communication traffic and significantly relax the requirement...

  18. Derivation of linearized transfer functions for switching-mode regulations. Phase A: Current step-up and voltage step-up converters

    Science.gov (United States)

    Wong, R. C.; Owen, H. A., Jr.; Wilson, T. G.

    1981-01-01

    Small-signal models are derived for the power stage of the voltage step-up (boost) and the current step-up (buck) converters. The modeling covers operation in both the continuous-mmf mode and the discontinuous-mmf mode. The power stage in the regulated current step-up converter on board the Dynamics Explorer Satellite is used as an example to illustrate the procedures in obtaining the small-signal functions characterizing a regulated converter.

  19. 18 CFR 367.1740 - Account 174, Miscellaneous current and accrued assets.

    Science.gov (United States)

    2010-04-01

    ... POWER ACT AND NATURAL GAS ACT Balance Sheet Chart of Accounts Current and Accrued Assets § 367.1740... FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE PUBLIC UTILITY...

  20. 18 CFR 367.2430 - Account 243, Obligations under capital leases-Current.

    Science.gov (United States)

    2010-04-01

    ... POWER ACT AND NATURAL GAS ACT Balance Sheet Chart of Accounts Current and Accrued Liabilities § 367.2430... FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE PUBLIC UTILITY...