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Sample records for cski attila szilgyi

  1. Radioprotective effect of c-ski on rat skin fibroblast in vitro

    International Nuclear Information System (INIS)

    Liu Xia; Li Ping; Zhang En; Liu Ping; Zhou Ping; Zhou Yuanguo

    2006-01-01

    Objective: To examine radioprotective effect of c-ski on rat skin fibroblast in vitro and explore its possible mechanism. Methods: The effect of soft X-ray irradiation at dose varied from 2 to 8 Gy on cell apoptosis in rat skin fibroblast were determined by flow cytometry with Annexin-V-FITC-PI labelling. The effect of c-ski gene transfection on cell apoptosis was evaluated after soft X-ray irradiation of 4 Gy. The protein expressions of Bax and Bcl-2 after c-ski gene transfection were measured with the Western blot method. Results: Soft X-ray irradiation increases cell apoptosis, and the increase is proportional to the irradiation dose. Apoptosis ratio increases with time since the irradiation, and reaches its peak at 36h after the irradiation, c-ski gene was observed to markedly decrease apoptosis index at 24 h after soft X-ray irradiation of 4 Gy compared to the control group, significant increase of the protein expression of Bcl-2 was observed. C-ski gene was found no significant effect on the protein expression of Bax. Conclusion: c-ski gene can decrease radiation sensitivity of skin fibroblast, promoting Bcl-2 protein expression is one of its possible mechanism for this radioprotective effects. (authors)

  2. ATTILA - Atmospheric Tracer Transport In a Langrangian Model

    Energy Technology Data Exchange (ETDEWEB)

    Reithmeier, C.; Sausen, R.

    2000-07-01

    The Lagrangian model ATTILA (atmospheric tracer transport in a Lagrangian model) has been developed to treat the global-scale transport of passive trace species in the atmosphere within the framework of a general circulation model (GCM). ATTILA runs online within the GCM ECHAM4 and uses the GCM produced wind field to advect the centrois of 80.000 to 180.000 constant mass air parcels into which the model atmosphere is divided. Each trace constituent is thereby represented by a mass mixing ratio in each parcel. ATTILA contains state-of-the-art parameterizations of convection, turbulent boundary layer mixing, and interparcel transport and provides an algorithm to map the tracer concentrations from the trajectories to the ECHAM model grid. We use two experiments to evaluate the transport characteristics of ATTILA against observations and the standard semiLagrangian transport scheme of ECHAM. In the first experiment we simulate the distribution of the short-lived tracer Radon ({sup 222}Rn) in order to examine fast vertical transport over continents, and long-range transport from the continents to remote areas. In the second experiment, we simulate the distribution of radiocarbon ({sup 14}C) that was injected into the northern stratosphere during the nuclear weapon tests in the early 60ties, in order to examine upper tropospheric and stratospheric transport characteristics. ATTILA compares well to the observations and in many respects to the semiLagrangian scheme. However, contrary to the semiLagrangian scheme, ATTILA shows a greatly reduced meridional transport in the upper troposphere and lower stratosphere, and a reduced downward flux from the stratosphere to the troposphere, especially in midlatitudes. Since both transport schemes use the same model meteorology, we conclude that the often cited enhanced meridional transport and overestimated downward flux in ECHAM as described above is rather due to the numerical properties of the semiLagrangian scheme than due to an

  3. Some steps of the dismantling of the hot cell ATTILA

    International Nuclear Information System (INIS)

    Terrasson, L.

    1989-01-01

    This paper describes the dismantling, during 2 years and just finished now, of a large hot cell (11.6 m x 5.90 m x 5.80 m) at Fontenay-aux-Roses (France) characterised by an importand irradiation and contamination mean dose rate 7 rads/hr, in some places 20 rads/hr, coming at 98 % from Cesium 137 (beta decay radioisotope). Put into operation in March 1967, the Attila cell was used for spent fuel processing using halogenides [fr

  4. Attila calculations for the 3-D C5G7 benchmark extension

    International Nuclear Information System (INIS)

    Wareing, T.A.; McGhee, J.M.; Barnett, D.A.; Failla, G.A.

    2005-01-01

    The performance of the Attila radiation transport software was evaluated for the 3-D C5G7 MOX benchmark extension, a follow-on study to the MOX benchmark developed by the 'OECD/NEA Expert Group on 3-D Radiation Transport Benchmarks'. These benchmarks were designed to test the ability of modern deterministic transport methods to model reactor problems without spatial homogenization. Attila is a general purpose radiation transport software package with an integrated graphical user interface (GUI) for analysis, set-up and postprocessing. Attila provides solutions to the discrete-ordinates form of the linear Boltzmann transport equation on a fully unstructured, tetrahedral mesh using linear discontinuous finite-element spatial differencing in conjunction with diffusion synthetic acceleration of inner iterations. The results obtained indicate that Attila can accurately solve the benchmark problem without spatial homogenization. (authors)

  5. ATTILA 2 S. A technical and interactive test language for architecture allowing simultaneity

    International Nuclear Information System (INIS)

    Batllo, M.

    1980-01-01

    The name ATTILA 2 S is inspired from ATLAS, test language adopted by the Department of Defence of America (D.O.D.) but cannot be implemented on our installation. ATTILA 2 S is principally characterized by: its technical vocabulary (P.O.L.), its interactivity, its simultaneity with main job (Multiprogramming and Multiprocessing allowed by multiprocessors architecture. This language has been developed for the Paris C.R.T. system (Photographies analysis system) on Control Data Cyber 72 computer [fr

  6. Applications of the 3-D Deterministic Transport Attila(regsign) for Core Safety Analysis

    International Nuclear Information System (INIS)

    Lucas, D.S.; Gougar, D.; Roth, P.A.; Wareing, T.; Failla, G.; McGhee, J.; Barnett, A.

    2004-01-01

    An LDRD (Laboratory Directed Research and Development) project is ongoing at the Idaho National Engineering and Environmental Laboratory (INEEL) for applying the three-dimensional multi-group deterministic neutron transport code (Attila(reg s ign)) to criticality, flux and depletion calculations of the Advanced Test Reactor (ATR). This paper discusses the model development, capabilities of Attila, generation of the cross-section libraries, and comparisons to an ATR MCNP model and future

  7. Modeling a TRIGA Mark II reactor using the Attila three-dimensional deterministic transport code

    International Nuclear Information System (INIS)

    Keller, S.T.; Palmer, T.S.; Wareing, T.A.

    2005-01-01

    A benchmark model of a TRIGA reactor constructed using materials and dimensions similar to existing TRIGA reactors was analyzed using MCNP and the recently developed deterministic transport code Attila TM . The benchmark reactor requires no MCNP modeling approximations, yet is sufficiently complex to validate the new modeling techniques. Geometric properties of the benchmark reactor are specified for use by Attila TM with CAD software. Materials are treated individually in MCNP. Materials used in Attila TM that are clad are homogenized. Attila TM uses multigroup energy discretization. Two cross section libraries were constructed for comparison. A 16 group library collapsed from the SCALE 4.4.a 238 group library provided better results than a seven group library calculated with WIMS-ANL. Values of the k-effective eigenvalue and scalar flux as a function of location and energy were calculated by the two codes. The calculated values for k-effective and spatially averaged neutron flux were found to be in good agreement. Flux distribution by space and energy also agreed well. Attila TM results could be improved with increased spatial and angular resolution and revised energy group structure. (authors)

  8. Comparison study on neutronic analysis of the K-DEMO water cooled ceramic breeder blanket using MCNP and ATTILA

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jong Sung, E-mail: jspark@nfri.re.kr; Kwon, Sungjin; Im, Kihak

    2016-11-01

    Highlights: • A comparison study of main parameter calculations: neutron wall loading (NWL), tritium breeding ratio (TBR), and nuclear heating, on a Korean fusion demonstration reactor (K-DEMO) neutronic analysis model using MCNP and ATTILA was performed to investigate the feasibility of using ATTILA. • The calculation results of this study indicates that ATTILA showed close agreement with MCNP within ranges (3.3–28%). • Partly high discrepancy (17–28%) results between two codes existed to the nuclear heating calculation in high attenuating materials and radially thick structure regions. • The rest of the results showed small differences of NWL calculation (3.3%) and TBR distribution (3.9%). • ATTILA could be acceptable for K-DEMO neutronic analysis considering discrepancy (3.3–28%). - Abstract: A comparison study of main parameter calculations: neutron wall loading (NWL), tritium breeding ratio (TBR), and nuclear heating, on a Korean fusion demonstration reactor (K-DEMO) neutronic analysis model using MCNP and ATTILA was performed to investigate the feasibility of using ATTILA for the main parameter calculations. The model was created by commercial CAD program (Pro-Engineer™) as a 22.5° sector of tokamak consisting of major components such as blankets, shields, divertors, vacuum vessels (VV), toroidal field (TF) coils, and others, which was directly imported into ATTILA by Parasolid file. The discretizing in space, angle, and energy variables were refined for application of the K-DEMO neutronic analysis model through an iterative process since these variables greatly impact on accuracy, solution times, and memory consumptions in ATTILA. The main parameter calculations using ATTILA and the result of comparison studies indicate that the NWL distributions by two codes were almost agreed within discrepancy of 3.3%; the TBR distribution using ATTILA was slightly bigger than MCNP with a difference 3.9%; the nuclear heating values on TF coils and VV

  9. Pericles and Attila results for the C5G7 MOX benchmark problems

    International Nuclear Information System (INIS)

    Wareing, T.A.; McGhee, J.M.

    2002-01-01

    Recently the Nuclear Energy Agency has published a new benchmark entitled, 'C5G7 MOX Benchmark.' This benchmark is to test the ability of current transport codes to treat reactor core problems without spatial homogenization. The benchmark includes both a two- and three-dimensional problem. We have calculated results for these benchmark problems with our Pericles and Attila codes. Pericles is a one-,two-, and three-dimensional unstructured grid discrete-ordinates code and was used for the twodimensional benchmark problem. Attila is a three-dimensional unstructured tetrahedral mesh discrete-ordinate code and was used for the three-dimensional problem. Both codes use discontinuous finite element spatial differencing. Both codes use diffusion synthetic acceleration (DSA) for accelerating the inner iterations.

  10. ATTILA (All Type Target Independent Lund Algorithm) for nuclear collisions at ≅ 200 AGeV

    International Nuclear Information System (INIS)

    Gyulassy, M.; Lawrence Berkeley Lab., CA

    1987-08-01

    The Lund string model, Fritiof, is applied in the form of a Monte-Carlo event generator, ATTILA, to nuclear collisions in the 200 AGeV range. We study how uncertainties at the pp level amplify at the AB level and compare preliminary CERN data on multiplicity, transverse energy, and veto energy distributions to this linear extrapolation scheme from pp to AB dynamics. (orig.)

  11. Comparison of ATTILA{sup TM} and MCNP{sup TM} for fusion applications

    Energy Technology Data Exchange (ETDEWEB)

    Loughlin, M. [UKAEA Fusion, Culham Science Centre, Abingdon, Oxfordshire, OX (United Kingdom); Wareing, T.; Barnett, A.; Failla, G.; McGhee, J. [Transpire Inc., Gig Harbor WA (United States)

    2005-07-01

    This paper describes comparison of the results of neutron transport calculations using two very different codes. ATTILA{sup TM} is a discrete ordinates radiation transport code which models complex 3-D geometries using arbitrary tetrahedra. MCNP{sup TM} is a Monte-Carlo radiation transport code which models the geometry using a combinatorial representation. This code is more widely known within the fusion community where it has been extensively used. In contrast, this is the first reporting of the use of ATTILA for fusion applications. The purpose of the work described herein was to compare calculations by each code of the neutron spectra at points around a greatly simplified representation of a typical fusion experiment. Spectra, in twenty-seven energy groups, were calculated at five locations which are typical of fusion neutronics problems; these are i) within the torus wall, ii) opposite a port, iii) near the torus hall floor, iv) at a straight penetration through the torus hall roof, and v) at the exit of a labyrinth through the wall. A solution was obtained from ATTILA in one 24 hour run on a single processor. An MCNP run of a similar duration was required on 18 parallel processors. Excellent agreement was obtained at all locations with only some minor disparities at thermal neutron energies. (authors)

  12. Radiation transport analyses for IFMIF design by the Attila software using a Monte-Carlo source model

    International Nuclear Information System (INIS)

    Arter, W.; Loughlin, M.J.

    2009-01-01

    Accurate calculation of the neutron transport through the shielding of the IFMIF test cell, defined by CAD, is a difficult task for several reasons. The ability of the powerful deterministic radiation transport code Attila, to do this rapidly and reliably has been studied. Three models of increasing geometrical complexity were produced from the CAD using the CADfix software. A fourth model was produced to represent transport within the cell. The work also involved the conversion of the Vitenea-IEF database for high energy neutrons into a format usable by Attila, and the conversion of a particle source specified in MCNP wssaformat to a form usable by Attila. The final model encompassed the entire test cell environment, with only minor modifications. On a state-of-the-art PC, Attila took approximately 3 h to perform the calculations, as a consequence of a careful mesh 'layering'. The results strongly suggest that Attila will be a valuable tool for modelling radiation transport in IFMIF, and for similar problems

  13. MiR-34a/miR-93 target c-Ski to modulate the proliferaton of rat cardiac fibroblasts and extracellular matrix deposition in vivo and in vitro.

    Science.gov (United States)

    Zhang, Chengliang; Zhang, Yanfeng; Zhu, Hong; Hu, Jiajia; Xie, Zhongshang

    2018-06-01

    Cardiac fibrosis is associated with diverse heart diseases. In response to different pathological irritants, cardiac fibroblasts may be induced to proliferate and differentiate into cardiac myofibroblasts, thus contributing to cardiac fibrosis. TGF-β signaling is implicated in the development of heart failure through the induction of cardiac fibrosis. C-Ski, an inhibitory regulator of TGF-β signaling, has been reported to suppress TGF-β1-induced human cardiac fibroblasts' proliferation and ECM protein increase; however, the underlying molecular mechanism needs further investigation. In the present study, we demonstrated that c-Ski could ameliorate isoproterenol (ISO)-induced rat myocardial fibrosis model and TGF-β1-induced primary rat cardiac fibroblasts' proliferation, as well as extracellular matrix (ECM) deposition. The protein level of c-Ski was dramatically decreased in cardiac fibrosis and TGF-β1-stimulated primary rat cardiac fibroblasts. In recent decades, a family of small non-coding RNA, namely miRNAs, has been reported to regulate gene expression by interacting with diverse mRNAs and inducing either translational suppression or mRNA degradation. Herein, we selected miR-34a and miR-93 as candidate miRNAs that might target to regulate c-Ski expression. After confirming that miR-34a/miR-93 targeted c-Ski to inhibit its expression, we also revealed that miR-34a/miR-93 affected TGF-β1-induced fibroblasts' proliferation and ECM deposition through c-Ski. Taken together, we demonstrated a miR-34a/miR-93-c-Ski axis which modulates TGF-β1- and ISO-induced cardiac fibrosis in vitro and in vivo; targeting the inhibitory factors of c-Ski to rescue its expression may be a promising strategy for the treatment of cardiac fibrosis. Copyright © 2018 Elsevier Inc. All rights reserved.

  14. Investigating the global transport of trace species and the stratoshere-troposphere-exchange with the Lagrangian model ECHAM4/ATTILA; Untersuchungen zum globalen Spurenstofftransport und Stratosphaeren-Troposphaeren-Austausch mit dem Lagrangeschen Modell ECHAM4/ATTILA

    Energy Technology Data Exchange (ETDEWEB)

    Reithmeier, C.

    2001-07-01

    Investigating the chemical composition of the atmosphere and its influence on the global climate involves a large number of trace species. Therefore, the Lagrangian transport scheme ATTILA has been developed in this thesis. ATTILA runs online in the general circulation model ECHAM4 and, thus, can be used efficiently for studies involving many tracers. The present study discusses the problems which arise when applying Lagrangian methods on long range and global scale, and describes in detail the solutions developed for ATTILA. Transport experiments with both short-lived and long-lived tracers clearly show that ATTILA is numerically much less diffusive than the operational semi-Lagrangian scheme of ECHAM. It could be shown that the enhanced meridional transport in the tropopause region and the overestimated downward flux through the tropopause in ECHAM are rather due to the numerical properties of the semi-Lagrangian scheme than due to an incorrect circulation. Furthermore, the stratospheric dynamics has been investigated in this study by analysing trajectories and by calculating age spectra and mass fluxes. (orig.)

  15. SU-F-T-111: Investigation of the Attila Deterministic Solver as a Supplement to Monte Carlo for Calculating Out-Of-Field Radiotherapy Dose

    Energy Technology Data Exchange (ETDEWEB)

    Mille, M; Lee, C [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD (United States); Failla, G [Varian Medical Systems, Gig Harbor, WA (United States)

    2016-06-15

    Purpose: To use the Attila deterministic solver as a supplement to Monte Carlo for calculating out-of-field organ dose in support of epidemiological studies looking at the risks of second cancers. Supplemental dosimetry tools are needed to speed up dose calculations for studies involving large-scale patient cohorts. Methods: Attila is a multi-group discrete ordinates code which can solve the 3D photon-electron coupled linear Boltzmann radiation transport equation on a finite-element mesh. Dose is computed by multiplying the calculated particle flux in each mesh element by a medium-specific energy deposition cross-section. The out-of-field dosimetry capability of Attila is investigated by comparing average organ dose to that which is calculated by Monte Carlo simulation. The test scenario consists of a 6 MV external beam treatment of a female patient with a tumor in the left breast. The patient is simulated by a whole-body adult reference female computational phantom. Monte Carlo simulations were performed using MCNP6 and XVMC. Attila can export a tetrahedral mesh for MCNP6, allowing for a direct comparison between the two codes. The Attila and Monte Carlo methods were also compared in terms of calculation speed and complexity of simulation setup. A key perquisite for this work was the modeling of a Varian Clinac 2100 linear accelerator. Results: The solid mesh of the torso part of the adult female phantom for the Attila calculation was prepared using the CAD software SpaceClaim. Preliminary calculations suggest that Attila is a user-friendly software which shows great promise for our intended application. Computational performance is related to the number of tetrahedral elements included in the Attila calculation. Conclusion: Attila is being explored as a supplement to the conventional Monte Carlo radiation transport approach for performing retrospective patient dosimetry. The goal is for the dosimetry to be sufficiently accurate for use in retrospective

  16. Neutronics analysis of the International Thermonuclear Experimental Reactor (ITER) MCNP ''Benchmark CAD Model'' with the ATTILA discrete ordinance code

    International Nuclear Information System (INIS)

    Youssef, M.Z.; Feder, R.; Davis, I.

    2007-01-01

    The ITER IT has adopted the newly developed FEM, 3-D, and CAD-based Discrete Ordinates code, ATTILA for the neutronics studies contingent on its success in predicting key neutronics parameters and nuclear field according to the stringent QA requirements set forth by the Management and Quality Program (MQP). ATTILA has the advantage of providing a full flux and response functions mapping everywhere in one run where components subjected to excessive radiation level and strong streaming paths can be identified. The ITER neutronics community had agreed to use a standard CAD model of ITER (40 degree sector, denoted ''Benchmark CAD Model'') to compare results for several responses selected for calculation benchmarking purposes to test the efficiency and accuracy of the CAD-MCNP approach developed by each party. Since ATTILA seems to lend itself as a powerful design tool with minimal turnaround time, it was decided to benchmark this model with ATTILA as well and compare the results to those obtained with the CAD MCNP calculations. In this paper we report such comparison for five responses, namely: (1) Neutron wall load on the surface of the 18 shield blanket module (SBM), (2) Neutron flux and nuclear heating rate in the divertor cassette, (3) nuclear heating rate in the winding pack of the inner leg of the TF coil, (4) Radial flux profile across dummy port plug and shield plug placed in the equatorial port, and (5) Flux at seven point locations situated behind the equatorial port plug. (orig.)

  17. Reseña de obra: TANZI, Attila M., International Law: a concise introduction

    Directory of Open Access Journals (Sweden)

    Leopoldo M. A. Godio

    2017-10-01

    Full Text Available Attila Tanzi, profesor de extensa y reconocida trayectoria en Europa que encuentra también una “casa académica” en Buenos Aires, se adentra en un estudio que presenta una estructura divida en capítulos que se inicia con un análisis del derecho internacional público de una forma “clásica” o más habitual en la enseñanza del derecho constitucional o administrativo: comienza desde el Estado, sus ámbitos de acción y relación para, posteriormente, señalar e individualizar los límites al poder estatal que –desde su primera página– aclara al lector sobre la extensión que posee más allá de sus fronteras (...

  18. Benchmarking the cad-based attila discrete ordinates code with experimental data of fusion experiments and to the results of MCNP code in simulating ITER

    International Nuclear Information System (INIS)

    Youssef, M. Z.

    2007-01-01

    Attila is a newly developed finite element code based on Sn neutron, gamma, and charged particle transport in 3-D geometry in which unstructured tetrahedral meshes are generated to describe complex geometry that is based on CAD input (Solid Works, Pro/Engineer, etc). In the present work we benchmark its calculation accuracy by comparing its prediction to the measured data inside two experimental mock-ups bombarded with 14 MeV neutrons. The results are also compared to those based on MCNP calculations. The experimental mock-ups simulate parts of the International Thermonuclear Experimental Reactor (ITER) in-vessel components, namely: (1) the Tungsten mockup configuration (54.3 cm x 46.8 cm x 45 cm), and (2) the ITER shielding blanket followed by the SCM region (simulated by alternating layers of SS316 and copper). In the latter configuration, a high aspect ratio rectangular streaming channel was introduced (to simulate steaming paths between ITER blanket modules) which ends with a rectangular cavity. The experiments on these two fusion-oriented integral experiments were performed at the Fusion Neutron Generator (FNG) facility, Frascati, Italy. In addition, the nuclear performance of the ITER MCNP 'Benchmark' CAD model has been performed with Attila to compare its results to those obtained with CAD-based MCNP approach developed by several ITER participants. The objective of this paper is to compare results based on two distinctive 3-D calculation tools using the same nuclear data, FENDL2.1, and the same response functions of several reaction rates measured in ITER mock-ups and to enhance confidence from the international neutronics community in the Attila code and how it can precisely quantify the nuclear field in large and complex systems, such as ITER. Attila has the advantage of providing a full flux mapping visualization everywhere in one run where components subjected to excessive radiation level and strong streaming paths can be identified. In addition, the

  19. Visit of H.E. Mr. Attila Chikan, Minister of Economic Affairs, Prof. Adam Török, President, National Committee for Technological Development, Mr. Pal Koncz, Deputy Director General, National Committee for Technological Development, Hungary

    CERN Multimedia

    Laurent Guiraud

    1999-01-01

    Visit of H.E. Mr. Attila Chikan, Minister of Economic Affairs, Prof. Adam Török, President, National Committee for Technological Development, Mr. Pal Koncz, Deputy Director General, National Committee for Technological Development, Hungary

  20. QTLs associated with agronomic traits in the Attila × CDC Go spring wheat population evaluated under conventional management.

    Directory of Open Access Journals (Sweden)

    Jun Zou

    Full Text Available Recently, we investigated the effect of the wheat 90K single nucleotide polymorphic (SNP array and three gene-specific (Ppd-D1, Vrn-A1 and Rht-B1 markers on quantitative trait loci (QTL detection in a recombinant inbred lines (RILs population derived from a cross between two spring wheat (Triticum aestivum L. cultivars, 'Attila' and 'CDC Go', and evaluated for eight agronomic traits at three environments under organic management. The objectives of the present study were to investigate the effect of conventional management on QTL detection in the same mapping population using the same set of markers as the organic management and compare the results with organic management. Here, we evaluated 167 RILs for number of tillers (tillering, flowering time, maturity, plant height, test weight (grain volume weight, 1000 kernel weight, grain yield, and grain protein content at seven conventionally managed environments from 2008 to 2014. Using inclusive composite interval mapping (ICIM on phenotypic data averaged across seven environments and a subset of 1203 informative markers (1200 SNPs and 3 gene specific markers, we identified a total of 14 QTLs associated with flowering time (1, maturity (2, plant height (1, grain yield (1, test weight (2, kernel weight (4, tillering (1 and grain protein content (2. Each QTL individually explained from 6.1 to 18.4% of the phenotypic variance. Overall, the QTLs associated with each trait explained from 9.7 to 35.4% of the phenotypic and from 22.1 to 90.8% of the genetic variance. Three chromosomal regions on chromosomes 2D (61-66 cM, 4B (80-82 cM and 5A (296-297 cM harbored clusters of QTLs associated with two to three traits. The coincidental region on chromosome 5A harbored QTL clusters for both flowering and maturity time, and mapped about 2 cM proximal to the Vrn-A1 gene, which was in high linkage disequilibrium (0.70 ≤ r2 ≤ 0.75 with SNP markers that mapped within the QTL confidence interval. Six of the 14

  1. Acceleration of MCNP calculations for small pipes configurations by using Weigth Windows Importance cards created by the SN-3D ATTILA

    Science.gov (United States)

    Castanier, Eric; Paterne, Loic; Louis, Céline

    2017-09-01

    In the nuclear engineering, you have to manage time and precision. Especially in shielding design, you have to be more accurate and efficient to reduce cost (shielding thickness optimization), and for this, you use 3D codes. In this paper, we want to see if we can easily applicate the CADIS methods for design shielding of small pipes which go through large concrete walls. We assess the impact of the WW generated by the 3D-deterministic code ATTILA versus WW directly generated by MCNP (iterative and manual process). The comparison is based on the quality of the convergence (estimated relative error (σ), Variance of Variance (VOV) and Figure of Merit (FOM)), on time (computer time + modelling) and on the implement for the engineer.

  2. Kiss, Réka and Attila Viktor Soós, eds. 2015. Keletről Nyugatra. A kommunista mozgalom titkos pénzei ('From East to West - the Secret Money of the Communist Movement'. Budapest: Nemzeti Emlékezet Bizottsága. 144 pp.

    Directory of Open Access Journals (Sweden)

    Susan Glanz

    2016-10-01

    Full Text Available Kiss, Réka and Attila Viktor Soós, eds. 2015. Keletröl Nyugatra. A kommunista mozgalom titkos pénzei ('From East to West - the Secret Money of the Communist Movement'. Budapest: Nemzeti Emlékezet Bizottsága. 144 pp.

  3. How to operationalize open norms in hard and soft laws: reflections based on two distinct regulatory examples / Attila Kun

    Index Scriptorium Estoniae

    Kun, Attila

    2018-01-01

    Avalikest, hübriidsetest ja eraõiguslikest normidest tööõiguses Ungari töökoodeksi ja rahvusvaheliste 'soft law' standardite (ÜRO, OECD, ILO normide) näitel. Töötaja õiglase hindamise põhimõttest ja hoolsuskohustusest (due diligence)

  4. A versatile characterization of poly(N-isopropylacrylamideco-N,N!-methylene-bis-acrylamide) hydrogels for composition, mechanical strength, and rheology

    CSIR Research Space (South Africa)

    Chetty, A

    2013-01-01

    Full Text Available ?105 Available online at www.expresspolymlett.com DOI: 10.3144/expresspolymlett.2013.9 *Corresponding author, e-mail: vvargha@mail.bme.hu ? BME-PT as biosensors [12], molecular imprinting [13], fluid microchips [14], as well as numerous biomedical...., Nishimura T., Ohashi K., Ohkouchi H., Nango M.: Two-step imprinting procedure of inter- penetrating polymer network-type stimuli-responsive hydrogel-adsorbents. Polymer Journal, 35, 545?550 (2003). DOI: 10.1295/polymj.35.545 [14] Sugiura S., Szil?gyi A...

  5. Kohalolek / Gabriella Uhl ; tõlkinud Kaidi Lõhmus

    Index Scriptorium Estoniae

    Uhl, Gabriella

    2009-01-01

    Näitus "Traditsioon ja vastuvõtlikkus - kaasaegsed arengusuunad ungari fotokunstis" ArtDepoo galeriis 4.-29. septembrini. Ungari skulptori Attila Mata näitus Ungari Instituudi galeriis 4.-18. septembrini

  6. Comparison of a 3D multi‐group SN particle transport code with Monte Carlo for intercavitary brachytherapy of the cervix uteri

    Science.gov (United States)

    Wareing, Todd A.; Failla, Gregory; Horton, John L.; Eifel, Patricia J.; Mourtada, Firas

    2009-01-01

    A patient dose distribution was calculated by a 3D multi‐group SN particle transport code for intracavitary brachytherapy of the cervix uteri and compared to previously published Monte Carlo results. A Cs‐137 LDR intracavitary brachytherapy CT data set was chosen from our clinical database. MCNPX version 2.5.c, was used to calculate the dose distribution. A 3D multi‐group SN particle transport code, Attila version 6.1.1 was used to simulate the same patient. Each patient applicator was built in SolidWorks, a mechanical design package, and then assembled with a coordinate transformation and rotation for the patient. The SolidWorks exported applicator geometry was imported into Attila for calculation. Dose matrices were overlaid on the patient CT data set. Dose volume histograms and point doses were compared. The MCNPX calculation required 14.8 hours, whereas the Attila calculation required 22.2 minutes on a 1.8 GHz AMD Opteron CPU. Agreement between Attila and MCNPX dose calculations at the ICRU 38 points was within ±3%. Calculated doses to the 2 cc and 5 cc volumes of highest dose differed by not more than ±1.1% between the two codes. Dose and DVH overlays agreed well qualitatively. Attila can calculate dose accurately and efficiently for this Cs‐137 CT‐based patient geometry. Our data showed that a three‐group cross‐section set is adequate for Cs‐137 computations. Future work is aimed at implementing an optimized version of Attila for radiotherapy calculations. PACS number: 87.53.Jw

  7. Dismantling of a hot cell of high level activity. Method and tools used

    International Nuclear Information System (INIS)

    Jeantet, E.; Miquel, P.; Baudoin, J.C.; Moutonnet, A.

    1981-05-01

    The aim of this operation is the removal of all the equipment and the material introduced and used in the hot cell 'Attila' and its decontamination to obtain an irradiation level as low as possible to allow direct intervention. The Attila facilitie was build in 1964-1966 to study dry processing of irradiated fuels by halogenide volatility process. Dismantling of the out-cell and of the laboratory associated to the shielded cell, dismantling inside the shielded cell with the remote handling equipment of the cell and tools used for these operations are described in this article [fr

  8. Prima Vistale tuleb tuntud kirjanikke mitmest Euroopa riigist / Kaarel Kressa

    Index Scriptorium Estoniae

    Kressa, Kaarel, 1983-

    2010-01-01

    Prima Vista kirjandusfestivali külalisi: Leonie Swann, Attila Bartis, Dmitri Bõkov, Zinaida Lindén, Mihhail Šiškin, Fay Weldon, Jason Goodwin, Rosa Maria Rodríguez Magda, Inga Gaile, Juris Kronbergs, Guntars Godinš, Liana Langa

  9. A Deep Penetration Problem Calculation Using AETIUS:An Easy Modeling Discrete Ordinates Transport Code UsIng Unstructured Tetrahedral Mesh, Shared Memory Parallel

    Science.gov (United States)

    KIM, Jong Woon; LEE, Young-Ouk

    2017-09-01

    As computing power gets better and better, computer codes that use a deterministic method seem to be less useful than those using the Monte Carlo method. In addition, users do not like to think about space, angles, and energy discretization for deterministic codes. However, a deterministic method is still powerful in that we can obtain a solution of the flux throughout the problem, particularly as when particles can barely penetrate, such as in a deep penetration problem with small detection volumes. Recently, a new state-of-the-art discrete-ordinates code, ATTILA, was developed and has been widely used in several applications. ATTILA provides the capabilities to solve geometrically complex 3-D transport problems by using an unstructured tetrahedral mesh. Since 2009, we have been developing our own code by benchmarking ATTILA. AETIUS is a discrete ordinates code that uses an unstructured tetrahedral mesh such as ATTILA. For pre- and post- processing, Gmsh is used to generate an unstructured tetrahedral mesh by importing a CAD file (*.step) and visualizing the calculation results of AETIUS. Using a CAD tool, the geometry can be modeled very easily. In this paper, we describe a brief overview of AETIUS and provide numerical results from both AETIUS and a Monte Carlo code, MCNP5, in a deep penetration problem with small detection volumes. The results demonstrate the effectiveness and efficiency of AETIUS for such calculations.

  10. Implementació d'un Tesselador de DirectX 11 per una targeta gràfica

    OpenAIRE

    Ramírez Guerrero, Daniel

    2012-01-01

    El objetivo del proyecto es efectuar un estudio sobre la etapa de teselación de DirectX 11 y ofrecer una implementación de una versión muy básica en el simulador de tarjetas gráficas del proyecto ATTILA.

  11. Chaos Theory and International Relations

    Science.gov (United States)

    2016-12-01

    King Oscar II 12 James E. Glenn, Chaos Theory: The Essentials for Military Applications (Newport, RI...Adolf Hitler in Germany, Alexander’s conquest of the Persian Empire, the arrival of Attila to Europe, the onset of the two Gulf Wars, the Arab Spring

  12. Distributed Simulation in Industry

    NARCIS (Netherlands)

    C.A. Boer (Csaba)

    2005-01-01

    textabstractCsaba Attila Boer was born in Satu Mare, Romania, on 29 October, 1975. He completed his secondary education at Kölcsey Ferenc High School, in Satu Mare, in 1994. In the same year he started his higher education at Babeş-Bolyai University, Faculty of Mathematics and Computer Science,

  13. Heat stress in wheat (Triticum aestivum L.): Effects on grain growth and quality traits

    NARCIS (Netherlands)

    Spiertz, J.H.J.; Hamer, R.J.; Xu, H.; Primo-Martin, C.; Don, C.; Putten, P.E.L. van der

    2006-01-01

    Heat stress effects on grain dry mass and quality were studied in spring wheat genotypes (Triticum aestivum L.). Three cultivars were chosen with respect to heat tolerance: Lavett (genotype 1), selected for temperate growing conditions and two CIMMYT cultivars, Ciano-79 (genotype 2) and Attila

  14. Festival Euroopa südames / Jaan Ruus

    Index Scriptorium Estoniae

    Ruus, Jaan, 1938-2017

    2004-01-01

    Karlovy Vary festivalist. Kuldgloobuse sai itaallaste Andrea ja Antonio Frazzi "Lastelugu" ("Certi bambini"), parima režii preemia sai hispaanlane Xavier Bermudez ("Leon ja Olvido"), naiskõrvalosa preemia anti Karen Lise Mynsterile ( taanlase Paprika Steeni "Tagajärjed"). Ka ungari filmist "Pärast eelmist päeva" (režii Attila Janisch), prantsuse "Kooripoisid" (režii Christophe Barratier), india "Vihmamantel" (režii Rituparno Ghosh), vene "Minu kasuvend Frankenstein" (Valeri Todorovski)

  15. National Security And Institutional Pathologies: A Path Dependent Analysis Of U.S. Interventions In Iran, Guatemala, Cuba, And Iraq

    Science.gov (United States)

    2016-09-01

    of social forces” within Iran, and that the company was involved in “activities in intelligence, bribery , and political intrigue,” often acting as a...upswing.”213 Perkins’ arguments won President Eisenhower’s endorsement. Christopher Baughn and Attila Yaprak found linkage between nationalistic...indicator being the level of perceived threat felt within the state.215 Baughn and Yaprak felt that these indicators may be useful in tracking the “ebb and

  16. D-T neutron streaming experiment simulating narrow gaps in ITER equatorial port

    International Nuclear Information System (INIS)

    Ochiai, K.; Sato, S.; Wada, M.; Iida, H.; Takakura, K.; Kutsukake, C.; Tanaka, S.; Abe, Y.; Konno, C.

    2008-01-01

    Under the ITER/ITA task, we have conducted the neutron streaming experiment simulating narrow and deep gaps at boundaries between ITER vacuum vessel and equatorial port plugs. Micro-fission chambers and some activation foils were used to measure fission rates and reaction rates to evaluate the relative fast and slow neutron fluences along the gap in the experimental assembly. The MCNP4C, TORT and Attila codes were used for the experimental analysis. From comparing our measurements and calculations, the following facts were found: (1) in case of a such narrow and deep gap structure, the calculation with MCNP, TORT and Attila codes and FENDL-2.1 is sufficient to predict fast neutron field inside the gap; (2) by scattering neutrons in the experimental room, experimental error considerably increased at the deeper region than 100 cm; (3) angular quadrature set of upward biased U315 and last collided source calculation on TORT and Attila were very important technique for accurate estimation of neutron transport

  17. Collaborative Platform for DFM

    Science.gov (United States)

    2007-12-20

    vol.5754, no.1, 2004, pp. 164-76. USA. 43 Zhang G , Terry M, O’Brien S, Soper R, Mason M, Won Kim, Changan Wang, Hansen S, Lee J, Ganeshan J...especially Kim Chan, Phill Guillory, Sia Parsa, Attila Horvath , and Anita Pongracz. iii I had the good fortune to participate in the FLCC grant...99 10 2 10 4 10 7 10 9 CD (nm) n u m b e r o f g a te s 0nm defocus 120nm defocus Figure 3 CD distribution of 160 gates at 0nm defocus and 120nm

  18. 80 aastat tagasi : November 1928 / Mati Märtin

    Index Scriptorium Estoniae

    Märtin, Mati

    2008-01-01

    Muusikasündmustest 80 aastat tagasi: 25. nov. õnnistati Pärnu Eliisabethi kiriku uus orel, kontserdi andsid organist Paul Pressnikoff ja laulja Alice Kopli-Wiegand, vaimulikul kontserdil 4. nov. Tartu Ülikooli kirikus esinesid laulja Ella Lipand, viiuldaja Voldemar Pikk ja organist Georg Pastarus, Johannes Jürgensoni (Juhan Jürme) helitööde õhtust 4. nov. Tallinna Tütarlaste Kommertsgümnaasiumis, Miina Hermanni Lauluseltsi kontserdist 4. nov. Tallinna Kaarli kirikus, soome baritoni Paavo Attila vaimuliku muusika kontserdist 11. nov. Tallinna Jaani kirikus, kirikliku talitusega tähistasid oma aastapäevi Tartu üliõpilaskorporatsionid Ugala ja Rotalia

  19. Scratching the surface of tomorrow's diagnostics: the Editor-in-Chief's opinion at the 15th year of Expert Review of Molecular Diagnostics.

    Science.gov (United States)

    Lorincz, Attila; Raison, Claire

    2015-01-01

    Interview with Attila Lorincz by Claire Raison (Commissioning Editor) To mark the beginning of the 15th year of Expert Review of Molecular Diagnostics, the journal's Editor-in-Chief shares his expert knowledge on translational diagnostics, his opinion on recent controversies and his predictions for molecular diagnostics in 2015 and beyond. Attila Lorincz received his doctorate from Trinity College, Dublin, Republic of Ireland, and went on to become a research fellow at the University of California, Santa Barbara, CA, USA. During Professor Lorincz's research on human papillomavirus (HPV), he found several important and novel carcinogenic HPV types and pioneered the use of HPV DNA testing for clinical diagnostics. In 1988, Professor Lorincz's team produced the first HPV test to be FDA-approved for patients and in 2003, for general population cervical precancer screening. Now Professor of Molecular Epidemiology at the Centre for Cancer Prevention, Queen Mary University of London, UK, he and his team are furthering translational research into DNA methylation assays for cancer risk prediction.

  20. Saul Fia

    Directory of Open Access Journals (Sweden)

    Gonçal Mayos

    2017-11-01

    Full Text Available Reseña de: Saul fia (El hijo de Saúl, Año 2015, Duración 107 min., País Hungría, Director László Nemes, Guión László Nemes, Clara Royer, Música László Melis, Fotografía Mátyás Erdély; Reparto: Géza Röhrig,  Levente Molnár,  Urs Rechn,  Sándor Zsótér,  Todd Charmont,  Björn Freiberg,  Uwe Lauer,  Attila Fritz,  Kamil Dobrowolski,  Christian Harting;  Productora Laokoon Filmgroup.

  1. Modelling the exposure induced by a criticality excursion in solution

    International Nuclear Information System (INIS)

    Kerouanton, David; Delgovea, Laure; Castaniera, Eric; Raimondia, Nicolas

    2008-01-01

    During a criticality accident, significant exposure is generated by 4 radiation origins: radiation directly induced by fissions (prompt neutrons and gamma), gamma radiations induced by (n, γ) reactions in crossed materials (capture gamma) and gamma radiations emitted by fission products. Due to boiling of the solution, a fraction of fissions products is airborne and is deposited in the ventilation shafts. 5.10 18 fissions are considered in a dissolution tank containing uranyl nitrate by using the deterministic ATTILA radiation transport code. Instantaneous radiations rates are evaluated as a function of the distance and compared with data available in the literature. Dose rates induced behind various shielding materials such as concrete, steel or glass are assessed. In all cases, relative contributions of prompt or capture radiations is detailed. (author)

  2. Radiative transport-based frequency-domain fluorescence tomography

    International Nuclear Information System (INIS)

    Joshi, Amit; Rasmussen, John C; Sevick-Muraca, Eva M; Wareing, Todd A; McGhee, John

    2008-01-01

    We report the development of radiative transport model-based fluorescence optical tomography from frequency-domain boundary measurements. The coupled radiative transport model for describing NIR fluorescence propagation in tissue is solved by a novel software based on the established Attila(TM) particle transport simulation platform. The proposed scheme enables the prediction of fluorescence measurements with non-contact sources and detectors at a minimal computational cost. An adjoint transport solution-based fluorescence tomography algorithm is implemented on dual grids to efficiently assemble the measurement sensitivity Jacobian matrix. Finally, we demonstrate fluorescence tomography on a realistic computational mouse model to locate nM to μM fluorophore concentration distributions in simulated mouse organs

  3. International Symposium on Scientific Computing, Computer Arithmetic and Validated Numerics

    CERN Document Server

    DEVELOPMENTS IN RELIABLE COMPUTING

    1999-01-01

    The SCAN conference, the International Symposium on Scientific Com­ puting, Computer Arithmetic and Validated Numerics, takes place bian­ nually under the joint auspices of GAMM (Gesellschaft fiir Angewandte Mathematik und Mechanik) and IMACS (International Association for Mathematics and Computers in Simulation). SCAN-98 attracted more than 100 participants from 21 countries all over the world. During the four days from September 22 to 25, nine highlighted, plenary lectures and over 70 contributed talks were given. These figures indicate a large participation, which was partly caused by the attraction of the organizing country, Hungary, but also the effec­ tive support system have contributed to the success. The conference was substantially supported by the Hungarian Research Fund OTKA, GAMM, the National Technology Development Board OMFB and by the J6zsef Attila University. Due to this funding, it was possible to subsidize the participation of over 20 scientists, mainly from Eastern European countries. I...

  4. Nuevos registros de aves en el bosque mesófilo de montaña del noreste de Hidalgo, México

    Directory of Open Access Journals (Sweden)

    Miguel Angel Martínez-Morales

    2015-06-01

    Full Text Available Se reportan nuevos registros y ampliaciones en el área de distribución de Harpagus bidentatus, Glaucidium sanchezi, Attila spadiceus, Cyanolyca nana, Oreoscoptes montanus y Peucedramus taeniatus. Estas seis especies de aves fueron registradas en el bosque mesófilo de montaña del estado de Hidalgo, México. Dos de estas especies (G. sanchezi y C. nana son especies de distribución restringida, lo que eleva a tres el número de especies de distribución restringida en la zona. Esto enfatiza la importancia de esta región en la conservación de la diversidad de aves. Se discuten las implicaciones de estos nuevos registros en la obtención de inventarios completos de la avifauna de la región y en la conservación de su diversidad de aves.

  5. The story of a historic morning

    CERN Multimedia

    2008-01-01

    "To be invited to CERN and also to be involved in a historic moment is a career dream. It’s a place where everyone learns from each other and contributes their speciality to construct something unique that defies understanding." Trivan Pal, Paul Scherrer Institute "CERN is an organization of many challenges, it is difficult to represent its size and quality. Its achievements are stacked like Russian dolls in order to build a true giant." Attila Razc CERN, PH "CERN is more than a place of work. The scope of its projects and the zest of its personnel make it a place to work and to live." Pavel Tashev, Summer Student "The research happening here is such that it needs at least one or two years of a doctorate to grasp its ra...

  6. Irradiation facility at the TRIGA Mainz for treatment of liver metastases

    Energy Technology Data Exchange (ETDEWEB)

    Hampel, G. [Institut fuer Kernchemie, Johannes Gutenberg-Universitaet Mainz, Fritz-Strassmann-Weg 2, D-55128 Mainz (Germany)], E-mail: gabriele.hample@uni-mainz.de; Wortmann, B. [Evonik Energy Services GmbH Essen, Ruettenscheider Str. 1-3, D-45128 Essen (Germany); Blaickner, M. [Austrian Research Centers, 2444 Seibersdorf (Austria); Knorr, J. [TU Dresden, Institut fuer Energietechnik, D-01062 Dresden (Germany); Kratz, J.V. [Institut fuer Kernchemie, Johannes Gutenberg-Universitaet Mainz, Fritz-Strassmann-Weg 2, D-55128 Mainz (Germany); Lizon Aguilar, A. [Evonik Energy Services GmbH Essen, Ruettenscheider Str. 1-3, D-45128 Essen (Germany); Minouchehr, S. [Transplantationschirurgie, Universitaetsklinikum Mainz, D-55131 Mainz (Germany); Nagels, S. [Forschungszentrum Karlsruhe GmbH, Institut fuer Strahlenforschung (ISF), Postfach 3640, D-76021 Karlsruhe (Germany); Otto, G. [Transplantationschirurgie, Universitaetsklinikum Mainz, D-55131 Mainz (Germany); Schmidberger, H. [Klinik und Poliklinik fuer Radioonkologie und Strahlentherapie, Universitaetsklinikum Mainz, D-55131 Mainz (Germany); Schuetz, C.; Vogtlaender, L. [Institut fuer Kernchemie, Johannes Gutenberg-Universitaet Mainz, Fritz-Strassmann-Weg 2, D-55128 Mainz (Germany)

    2009-07-15

    The TRIGA Mark II reactor at University of Mainz provides ideal conditions for duplicating BNCT treatment as performed in Pavia, Italy, in 2001 and 2003 [Pinelli, T., Zonta, A., Altieri, S., Barni, S., Braghieri, A., Pedroni, P., Bruschi, P., Chiari, P., Ferrari, C., Fossati, F., Nano, R., Ngnitejeu Tata, S., Prati, U., Ricevuti, G., Roveda, L., Zonta, C., 2002. TAOrMINA: from the first idea to the application to the human liver. In: Sauerwein et al. (Eds.), Research and Development in Neutron Capture Therapy. Proceedings of the 10th International Congress on Neutron Capture Therapy, Monduzzi editore, Bologna, pp. 1065-1072]. In order to determine the optimal parameters for the planned therapy and therefore for the design of the thermal column, calculations were conducted using the MCNP-code and the transport code ATTILA. The results of the parameter study as well as a possible configuration for the irradiation of the liver are presented.

  7. A Semiactive and Adaptive Hybrid Control System for a Tracked Vehicle Hydropneumatic Suspension Based on Disturbance Identification

    Directory of Open Access Journals (Sweden)

    Shousong Han

    2017-01-01

    Full Text Available The riding conditions for a high-speed tracked vehicle are quite complex. To enhance the adaptability of suspension systems to different riding conditions, a semiactive and self-adaptive hybrid control strategy based on disturbance velocity and frequency identification was proposed. A mathematical model of the semiactive, self-adaptive hybrid suspension control system, along with a performance evaluation function, was established. Based on a two-degree-of-freedom (DOF suspension system, the kinematic relations and frequency zero-crossing detection method were defined, and expressions for the disturbance velocity and disturbance frequency of the road were obtained. Optimal scheduling of the semiactive hybrid damping control gain (csky, cground, chybrid and self-adaptive control gain (cv under different disturbances were realized by exploiting the particle swarm multiobjective optimization algorithm. An experimental study using a carefully designed test rig was performed under a number of typical riding conditions of tracked vehicles, and the results showed that the proposed control strategy is capable of accurately recognizing different disturbances, shifting between control modes (semiactive/self-adaptive, and scheduling the damping control gain according to the disturbance identification outcomes; hence, the proposed strategy could achieve a good trade-off between ride comfort and ride safety and efficiently increase the overall performance of the suspension under various riding conditions.

  8. Roles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes

    International Nuclear Information System (INIS)

    Wang Bei; Suzuki, Hiroyuki; Kato, Mitsuyasu

    2008-01-01

    TGF-β activates receptor-regulated Smad (R-Smad) through phosphorylation by type I receptors. Activated R-Smad binds to Smad4 and the complex translocates into the nucleus and stimulates the transcription of target genes through association with co-activators including p300. It is not clear, however, how activated Smad complexes are removed from target genes. In this study, we show that TGF-β enhances the mono-ubiquitination of Smad4. Smad4 mono-ubiquitination was promoted by p300 and suppressed by the c-Ski co-repressor. Smad4 mono-ubiquitination disrupted the interaction with Smad2 in the presence of constitutively active TGF-β type I receptor. Furthermore, mono-ubiquitinated Smad4 was not found in DNA-binding Smad complexes. A Smad4-Ubiquitin fusion protein, which mimics mono-ubiquitinated Smad4, enhanced localization to the cytoplasm. These results suggest that mono-ubiquitination of Smad4 occurs in the transcriptional activator complex and facilitates the turnover of Smad complexes at target genes

  9. Induction of Ski Protein Expression upon Luteinization in Rat Granulosa Cells

    Directory of Open Access Journals (Sweden)

    Hyun Kim

    2012-05-01

    Full Text Available Ski protein is implicated in proliferation/differentiation in a variety of cells. We had previously reported that Ski protein is present in granulosa cells of atretic follicles, but not in preovulatory follicles, suggesting that Ski has a role in apoptosis of granulosa cells. The alternative fate of granulosa cells other than apoptosis is to differentiate to luteal cells; however, it is unknown whether Ski is expressed and has a role in granulosa cells undergoing luteinization. Thus, the aim of the present study was to locate Ski protein in the rat ovary during luteinizationto predict the possible role of Ski. In order to examine the expression pattern of Ski protein along with the progress of luteinization, follicular growth was induced by administration of equine chorionic gonadtropin to immature female rats, and luteinization was induced by human chorionic gonadtropin treatment to mimic luteinizing hormone (LH surge. While no Ski-positive granulosa cells were present in preovulatory follicle, Ski protein expression was induced in response to LH surge, and was maintained after the formation of the corpus luteum (CL. Though Ski protein is absent in granulosa cells of preovulatory follicle, its mRNA (c-Ski was expressed and the level was unchanged even after LH surge. Taken together, these results demonstrated that Ski protein expression is induced in granulosa cells upon luteinization, and suggests that its expression is regulated post-transcriptionally.

  10. State-of-the-art 3-D neutronics analysis methods for fusion energy systems

    International Nuclear Information System (INIS)

    Wilson, P.P.H.; Feder, R.; Fischer, U.; Loughlin, M.; Petrizzi, L.; Wu, Y.

    2007-01-01

    Recent advances in radiation transport simulation tools enable an increased fidelity and accuracy in modeling complex geometries in fusion systems. Future neutronics calculations for design and analysis will increasingly be based directly on 3-D CAD-based geometries, allowing enhanced model complexity, reduced human effort and improved quality assurance. Improvements have been made in both stochastic and deterministic radiation transport methodologies. To adapt the MCNP stochastic transport software, the translator approach allows CAD geometries to be converted from their native formats into standard input files, while the direct geometry approach uses computer graphics algorithms to perform the radiation transport on the CAD geometry itself. The former takes advantage of the efficiency of the native MCNP software without modifications while the latter permits the modeling of more complex surfaces. The ATTILA radiation transport package uses a finite-element formulation of the discrete-ordinate methodology to provide a deterministic solution on a tetrahedral mesh derived automatically from a CAD-based geometry. All of these tools are being applied to a dedicated benchmark problem consisting of a 40 degree sector of the ITER machine defined only in a CAD-based solid model. The specific benchmark problems exercise the ability to use a CAD-based geometry to solve a range of fusion neutronics problems including neutron wall loading, deep penetration and narrow duct streaming. The results of this exercise will be used to validate/qualify these tools for use on ITER. At the same time, many of these tools are being used to support the design of ITER components and other related fusion systems. UW has provided high-fidelity nuclear analysis of ITER first wall and shield modules identifying local effects of geometric features. ASIPP has used the MCAM tool to update and extend the existing ITER basic model and used it for neutronics analysis of the proposed Chinese ITER

  11. State-of-the-art 3-D neutronics analysis methods for fusion energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, P.P.H. [Wisconsin-Madison Univ., Madison, WI (United States); Feder, R. [Princeton Plasma Physics Lab. (United States); Fischer, U. [Forschungszentrum Karlsruhe (Germany); Loughlin, M. [United Kingdom Atomic Energy Authority (United Kingdom); Petrizzi, L. [ENEA-Frascati (Italy); Wu, Y. [Academy of Sciences (China). Inst. of Plasma Physics; Youssef, M. [California Univ., Los Angeles, CA (United States)

    2007-07-01

    Recent advances in radiation transport simulation tools enable an increased fidelity and accuracy in modeling complex geometries in fusion systems. Future neutronics calculations for design and analysis will increasingly be based directly on 3-D CAD-based geometries, allowing enhanced model complexity, reduced human effort and improved quality assurance. Improvements have been made in both stochastic and deterministic radiation transport methodologies. To adapt the MCNP stochastic transport software, the translator approach allows CAD geometries to be converted from their native formats into standard input files, while the direct geometry approach uses computer graphics algorithms to perform the radiation transport on the CAD geometry itself. The former takes advantage of the efficiency of the native MCNP software without modifications while the latter permits the modeling of more complex surfaces. The ATTILA radiation transport package uses a finite-element formulation of the discrete-ordinate methodology to provide a deterministic solution on a tetrahedral mesh derived automatically from a CAD-based geometry. All of these tools are being applied to a dedicated benchmark problem consisting of a 40 degree sector of the ITER machine defined only in a CAD-based solid model. The specific benchmark problems exercise the ability to use a CAD-based geometry to solve a range of fusion neutronics problems including neutron wall loading, deep penetration and narrow duct streaming. The results of this exercise will be used to validate/qualify these tools for use on ITER. At the same time, many of these tools are being used to support the design of ITER components and other related fusion systems. UW has provided high-fidelity nuclear analysis of ITER first wall and shield modules identifying local effects of geometric features. ASIPP has used the MCAM tool to update and extend the existing ITER basic model and used it for neutronics analysis of the proposed Chinese ITER

  12. Implications of Lagrangian transport for coupled chemistry-climate simulations

    Science.gov (United States)

    Stenke, A.; Dameris, M.; Grewe, V.; Garny, H.

    2008-10-01

    For the first time a purely Lagrangian transport algorithm is applied in a fully coupled chemistry-climate model (CCM). We use the Lagrangian scheme ATTILA for the transport of water vapour, cloud water and chemical trace species in the ECHAM4.L39(DLR)/CHEM (E39C) CCM. The advantage of the Lagrangian approach is that it is numerically non-diffusive and therefore maintains steeper and more realistic gradients than the operational semi-Lagrangian transport scheme. In case of radiatively active species changes in the simulated distributions feed back to model dynamics which in turn affect the modelled transport. The implications of the Lagrangian transport scheme for stratospheric model dynamics and tracer distributions in the upgraded model version E39C-ATTILA (E39C-A) are evaluated by comparison with observations and results of the E39C model with the operational semi-Lagrangian advection scheme. We find that several deficiencies in stratospheric dynamics in E39C seem to originate from a pronounced modelled wet bias and an associated cold bias in the extra-tropical lowermost stratosphere. The reduction of the simulated moisture and temperature bias in E39C-A leads to a significant advancement of stratospheric dynamics in terms of the mean state as well as annual and interannual variability. As a consequence of the favourable numerical characteristics of the Lagrangian transport scheme and the improved model dynamics, E39C-A generally shows more realistic stratospheric tracer distributions: Compared to E39C high stratospheric chlorine (Cly) concentrations extend further downward and agree now well with analyses derived from observations. Therefore E39C-A realistically covers the altitude of maximum ozone depletion in the stratosphere. The location of the ozonopause, i.e. the transition from low tropospheric to high stratospheric ozone values, is also clearly improved in E39C-A. Furthermore, the simulated temporal evolution of stratospheric Cly in the past is

  13. ITER Generic Diagnostic Upper Port Plug Nuclear Heating and Personnel Dose Rate Assessment

    International Nuclear Information System (INIS)

    Feder, Russell E.; Youssef, Mahmoud Z.

    2009-01-01

    Neutronics analysis to find nuclear heating rates and personnel dose rates were conducted in support of the integration of diagnostics in to the ITER Upper Port Plugs. Simplified shielding models of the Visible-Infrared diagnostic and of a large aperture diagnostic were incorporated in to the ITER global CAD model. Results for these systems are representative of typical designs with maximum shielding and a small aperture (Vis-IR) and minimal shielding with a large aperture. The neutronics discrete-ordinates code ATTILA(reg s ign) and SEVERIAN(reg s ign) (the ATTILA parallel processing version) was used. Material properties and the 500 MW D-T volume source were taken from the ITER 'Brand Model' MCNP benchmark model. A biased quadrature set equivalent to Sn=32 and a scattering degree of Pn=3 were used along with a 46-neutron and 21-gamma FENDL energy subgrouping. Total nuclear heating (neutron plug gamma heating) in the upper port plugs ranged between 380 and 350 kW for the Vis-IR and Large Aperture cases. The Large Aperture model exhibited lower total heating but much higher peak volumetric heating on the upper port plug structure. Personnel dose rates are calculated in a three step process involving a neutron-only transport calculation, the generation of activation volume sources at pre-defined time steps and finally gamma transport analyses are run for selected time steps. ANSI-ANS 6.1.1 1977 Flux-to-Dose conversion factors were used. Dose rates were evaluated for 1 full year of 500 MW DT operation which is comprised of 3000 1800-second pulses. After one year the machine is shut down for maintenance and personnel are permitted to access the diagnostic interspace after 2-weeks if dose rates are below 100 (micro)Sv/hr. Dose rates in the Visible-IR diagnostic model after one day of shutdown were 130 (micro)Sv/hr but fell below the limit to 90 (micro)Sv/hr 2-weeks later. The Large Aperture style shielding model exhibited higher and more persistent dose rates. After 1

  14. Functional interaction between Smad, CREB binding protein, and p68 RNA helicase

    International Nuclear Information System (INIS)

    Warner, Dennis R.; Bhattacherjee, Vasker; Yin, Xiaolong; Singh, Saurabh; Mukhopadhyay, Partha; Pisano, M. Michele; Greene, Robert M.

    2004-01-01

    The transforming growth factors β control a diversity of biological processes including cellular proliferation, differentiation, apoptosis, and extracellular matrix production, and are critical effectors of embryonic patterning and development, including that of the orofacial region. TGFβ superfamily members signal through specific cell surface receptors that phosphorylate the cytoplasmic Smad proteins, resulting in their translocation to the nucleus and interaction with promoters of TGFβ-responsive genes. Subsequent alterations in transcription are cell type-specific and dependent on recruitment to the Smad/transcription factor complex of coactivators, such as CBP and p300, or corepressors, such as c-ski and SnoN. Since the affinity of Smads for DNA is generally low, additional accessory proteins that facilitate Smad/DNA binding are required, and are often cell- and tissue-specific. In order to identify novel Smad 3 binding proteins in developing orofacial tissue, a yeast two hybrid assay was employed in which the MH2 domain of Smad 3 was used to screen an expression library derived from mouse embryonic orofacial tissue. The RNA helicase, p68, was identified as a unique Smad binding protein, and the specificity of the interaction was confirmed through various in vitro and in vivo assays. Co-expression of Smad 3 and a CBP-Gal4 DNA binding domain fusion protein in a Gal4-luciferase reporter assay resulted in increased TGFβ-stimulated reporter gene transcription. Moreover, co-expression of p68 RNA helicase along with Smad 3 and CBP-Gal4 resulted in synergistic activation of Gal4-luciferase reporter expression. Collectively, these data indicate that the RNA helicase, p68, can directly interact with Smad 3 resulting in formation of a transcriptionally active ternary complex containing Smad 3, p68, and CBP. This offers a means of enhancing TGFβ-mediated cellular responses in developing orofacial tissue

  15. Evidence-based management.

    Science.gov (United States)

    Pfeffer, Jeffrey; Sutton, Robert I

    2006-01-01

    For the most part, managers looking to cure their organizational ills rely on obsolete knowledge they picked up in school, long-standing but never proven traditions, patterns gleaned from experience, methods they happen to be skilled in applying, and information from vendors. They could learn a thing or two from practitioners of evidence-based medicine, a movement that has taken the medical establishment by storm over the past decade. A growing number of physicians are eschewing the usual, flawed resources and are instead identifying, disseminating, and applying research that is soundly conducted and clinically relevant. It's time for managers to do the same. The challenge is, quite simply, to ground decisions in the latest and best knowledge of what actually works. In some ways, that's more difficult to do in business than in medicine. The evidence is weaker in business; almost anyone can (and many people do) claim to be a management expert; and a motley crew of sources--Shakespeare, Billy Graham,Jack Welch, Attila the Hunare used to generate management advice. Still, it makes sense that when managers act on better logic and strong evidence, their companies will beat the competition. Like medicine, management is learned through practice and experience. Yet managers (like doctors) can practice their craft more effectively if they relentlessly seek new knowledge and insight, from both inside and outside their companies, so they can keep updating their assumptions, skills, and knowledge.

  16. Management Board - Meeting of 9 December 1999

    CERN Multimedia

    2000-01-01

    Hungarian Contribution to LHC Funding The Director-General said that he was pleased to announce that, following a number of fruitful contacts with the Hungarian authorities, including a recent visit to the Laboratory by the Hungarian Minister of Economic Affairs, Dr Attila Chikán, the sum of 1.5 MCHF covering Hungary's contribution to the LHC experiments CMS and Alice had been received in addition to its normal contribution to the CERN budget. Revision of Administrative Circulars Nos. 2 and 9 The Leader of Personnel Division, J. van der Boon, presented revised versions of draft administrative circulars Nos. 2 and 9 covering, respectively, 'Guidelines and Procedures concerning Recruitment and Probation Period of Staff Members' and 'Staff Members' Contracts'. The two circulars had been amended to take account of changes in the assessment process for long-term employment agreed by the Management Board at its meeting in May 1999, the principal thrust of which involved bringing forward in time the ma...

  17. MANAGEMENT BOARD MEETING OF 9 DECEMBER 1999

    CERN Multimedia

    2000-01-01

    Hungarian Contribution to LHC FundingThe Director-General said that he was pleased to announce that, following a number of fruitful contacts with the Hungarian authorities, including a recent visit to the Laboratory by the Hungarian Minister of Economic Affairs, Dr Attila Chikán, the sum of 1.5 MCHF covering Hungary's contribution to the LHC experiments CMS and Alice had been received in addition to its normal contribution to the CERN budget.Revision of Administrative Circulars Nos. 2 and 9The Leader of Personnel Division, J. van der Boon, presented revised versions of draft administrative circulars Nos. 2 and 9 covering, respectively, 'Guidelines and Procedures concerning Recruitment and Probation Period of Staff Members' and 'Staff Members' Contracts'. The two circulars had been amended to take account of changes in the assessment process for long-term employment agreed by the Management Board at its meeting in May 1999, the principal thrust of which involved bringing forward in time the main fil...

  18. MCNP Variance Reduction technique application for the Development Of the Citrusdal Irradiation Facility

    International Nuclear Information System (INIS)

    Makgae, R.

    2008-01-01

    A private company, Citrus Research International (CIR) is intending to construct an insect irradiation facility for the irradiation of insect for pest management in south western region of South Africa. The facility will employ a Co-60 cylindrical source in the chamber. An adequate thickness for the concrete shielding walls and the ability of the labyrinth leading to the irradiation chamber, to attenuate radiation to dose rates that are acceptably low, were determined. Two methods of MCNP variance reduction techniques were applied to accommodate the two pathways of deep penetration to evaluate the radiological impact outside the 150 cm concrete walls and steaming of gamma photons through the labyrinth. The point-kernel based MicroShield software was used in the deep penetration calculations for the walls around the source room to test its accuracy and the results obtained are in good agreement with about 15-20% difference. The dose rate mapping due to radiation Streaming along the labyrinth to the facility entrance is also to be validated with the Attila code, which is a deterministic code that solves the Discrete Ordinates approximation. This file provides a template for writing papers for the conference. (authors)

  19. MCNP Variance Reduction technique application for the Development Of the Citrusdal Irradiation Facility

    Energy Technology Data Exchange (ETDEWEB)

    Makgae, R. [Pebble Bed Modular Reactor (PBMR), P.O. Box 9396, Centurion (South Africa)

    2008-07-01

    A private company, Citrus Research International (CIR) is intending to construct an insect irradiation facility for the irradiation of insect for pest management in south western region of South Africa. The facility will employ a Co-60 cylindrical source in the chamber. An adequate thickness for the concrete shielding walls and the ability of the labyrinth leading to the irradiation chamber, to attenuate radiation to dose rates that are acceptably low, were determined. Two methods of MCNP variance reduction techniques were applied to accommodate the two pathways of deep penetration to evaluate the radiological impact outside the 150 cm concrete walls and steaming of gamma photons through the labyrinth. The point-kernel based MicroShield software was used in the deep penetration calculations for the walls around the source room to test its accuracy and the results obtained are in good agreement with about 15-20% difference. The dose rate mapping due to radiation Streaming along the labyrinth to the facility entrance is also to be validated with the Attila code, which is a deterministic code that solves the Discrete Ordinates approximation. This file provides a template for writing papers for the conference. (authors)

  20. High Accuracy Potential Energy Surface, Dipole Moment Surface, Rovibrational Energies and Line List Calculations for ^{14}NH_3

    Science.gov (United States)

    Coles, Phillip; Yurchenko, Sergei N.; Polyansky, Oleg; Kyuberis, Aleksandra; Ovsyannikov, Roman I.; Zobov, Nikolay Fedorovich; Tennyson, Jonathan

    2017-06-01

    We present a new spectroscopic potential energy surface (PES) for ^{14}NH_3, produced by refining a high accuracy ab initio PES to experimental energy levels taken predominantly from MARVEL. The PES reproduces 1722 matched J=0-8 experimental energies with a root-mean-square error of 0.035 cm-1 under 6000 cm^{-1} and 0.059 under 7200 cm^{-1}. In conjunction with a new DMS calculated using multi reference configuration interaction (MRCI) and H=aug-cc-pVQZ, N=aug-cc-pWCVQZ basis sets, an infrared (IR) line list has been computed which is suitable for use up to 2000 K. The line list is used to assign experimental lines in the 7500 - 10,500 cm^{-1} region and previously unassigned lines in HITRAN in the 6000-7000 cm^{-1} region. Oleg L. Polyansky, Roman I. Ovsyannikov, Aleksandra A. Kyuberis, Lorenzo Lodi, Jonathan Tennyson, Andrey Yachmenev, Sergei N. Yurchenko, Nikolai F. Zobov, J. Mol. Spec., 327 (2016) 21-30 Afaf R. Al Derzia, Tibor Furtenbacher, Jonathan Tennyson, Sergei N. Yurchenko, Attila G. Császár, J. Quant. Spectrosc. Rad. Trans., 161 (2015) 117-130

  1. KNOWLEDGE AND OPINIONS OF SCHOOL CHILDREN ABOUT EPILEPSY

    Directory of Open Access Journals (Sweden)

    Slađana Jajić

    2013-12-01

    Full Text Available Epilepsy is one of the earliest diseases of the mankind, and is referred to as paroxysmal and transitory disturbance of brain function that is developing rapidly and has a tendency to recur. The aim of the paper was to determine the knowledge and attitudes of students in the eighth grade related to epilepsy. The study was conducted in March-April 2010. The survey comprised 193 eighth-grade students of both sexes. The study included children from the City of Novi Sad and two suburbs of the four elementary schools: "Ivo Lola Ribar" and "Attila Jožeg" from Novi Sad, "Đura Jakšić" from Kać and "Jovan Dučić" from Petrovaradin. The majority of students (98.4% had the knowledge about epilepsy. Half of the respondents had heard of it on television and one quarter from parents or in school. As a trigger of epileptic attacks, students usually mention insomnia (47.1% and food deficiency (19.5%. The most typical symptoms students described were foaming at the mouth, sudden loss of consciousness and convulsions. For most students (84.4%, epilepsy is considered an organic disease; one-third of respondents (34.4% considered epilepsy curable disease. The results indicate that students have the basic eighth-grade level of knowledge about epilepsy, including the fact that most of them (71.1% believe that a child with epilepsy can play and socialize with their peers.

  2. IMPROVED COMPUTATIONAL NEUTRONICS METHODS AND VALIDATION PROTOCOLS FOR THE ADVANCED TEST REACTOR

    Energy Technology Data Exchange (ETDEWEB)

    David W. Nigg; Joseph W. Nielsen; Benjamin M. Chase; Ronnie K. Murray; Kevin A. Steuhm

    2012-04-01

    The Idaho National Laboratory (INL) is in the process of modernizing the various reactor physics modeling and simulation tools used to support operation and safety assurance of the Advanced Test Reactor (ATR). Key accomplishments so far have encompassed both computational as well as experimental work. A new suite of stochastic and deterministic transport theory based reactor physics codes and their supporting nuclear data libraries (HELIOS, KENO6/SCALE, NEWT/SCALE, ATTILA, and an extended implementation of MCNP5) has been installed at the INL. Corresponding models of the ATR and ATRC are now operational with all five codes, demonstrating the basic feasibility of the new code packages for their intended purpose. Of particular importance, a set of as-run core depletion HELIOS calculations for all ATR cycles since August 2009 was successfully completed during 2011. This demonstration supported a decision late in the year to proceed with the phased incorporation of the HELIOS methodology into the ATR fuel cycle management process beginning in 2012. On the experimental side of the project, new hardware was fabricated, measurement protocols were finalized, and the first four of six planned physics code validation experiments based on neutron activation spectrometry were conducted at the ATRC facility. Data analysis for the first three experiments, focused on characterization of the neutron spectrum in one of the ATR flux traps, has been completed. The six experiments will ultimately form the basis for a flexible, easily-repeatable ATR physics code validation protocol that is consistent with applicable ASTM standards.

  3. Μεταξύ Αττίλα και Βαϊανού. Το Βυζάντιο και οι νομαδικοί λαοί από το 453 έως το 558

    Directory of Open Access Journals (Sweden)

    Γεώργιος ΚΑΡΔΑΡΑΣ

    2014-11-01

    Full Text Available Normal.dotm 0 0 1 152 870 獫票楧栮捯洀鉭曮㞱Û뜰⠲쎔딁烊皭〼፥ᙼ䕸忤઱ 7 1 1068 12.0 0 false 18 pt 18 pt 0 0 false false false /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-ascii-font-family:Cambria; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Cambria; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}  Between Attila and Bajan. Byzantium and the nomads from 453 to 558 The paper highlights the relations of Byzantium with the nomads in the period between the collapse of the Hunnic hegemony in Central Europe and the coming of the Avars to the northern frontiers of the Empire. Taking into account the written testimonies, as well as the archaeological finds, the geographical area of the nomadic settlements, the conflicts and treaties with Byzantium, the role of the nomads in the Byzantine-Persian relations, the nomad mercenaries in the Byzantine army and certain Byzantine finds, as jewellery, swords, pendant capsule or other decorative motifs are considered. These relations are distinguished in two periods, before and after 491. During the first one, the Empire was able to control the activity of the nomads offering them settlement permit on Byzantine soil, while for the second is noted, beside the strong conflicts, the cultural influence of Byzantium through Christianity and, on the other hand, the nomadic influences on the Byzantine army.   

  4. Advanced Test Reactor Core Modeling Update Project Annual Report for Fiscal Year 2011

    Energy Technology Data Exchange (ETDEWEB)

    David W. Nigg; Devin A. Steuhm

    2011-09-01

    Legacy computational reactor physics software tools and protocols currently used for support of Advanced Test Reactor (ATR) core fuel management and safety assurance and, to some extent, experiment management are obsolete, inconsistent with the state of modern nuclear engineering practice, and are becoming increasingly difficult to properly verify and validate (V&V). Furthermore, the legacy staff knowledge required for application of these tools and protocols from the 1960s and 1970s is rapidly being lost due to staff turnover and retirements. In 2009 the Idaho National Laboratory (INL) initiated a focused effort to address this situation through the introduction of modern high-fidelity computational software and protocols, with appropriate V&V, within the next 3-4 years via the ATR Core Modeling and Simulation and V&V Update (or 'Core Modeling Update') Project. This aggressive computational and experimental campaign will have a broad strategic impact on the operation of the ATR, both in terms of improved computational efficiency and accuracy for support of ongoing DOE programs as well as in terms of national and international recognition of the ATR National Scientific User Facility (NSUF). The ATR Core Modeling Update Project, targeted for full implementation in phase with the anticipated ATR Core Internals Changeout (CIC) in the 2014 time frame, began during the last quarter of Fiscal Year 2009, and has just completed its first full year. Key accomplishments so far have encompassed both computational as well as experimental work. A new suite of stochastic and deterministic transport theory based reactor physics codes and their supporting nuclear data libraries (SCALE, KENO-6, HELIOS, NEWT, and ATTILA) have been installed at the INL under various permanent sitewide license agreements and corresponding baseline models of the ATR and ATRC are now operational, demonstrating the basic feasibility of these code packages for their intended purpose. Furthermore

  5. Advanced Test Reactor Core Modeling Update Project Annual Report for Fiscal Year 2012

    Energy Technology Data Exchange (ETDEWEB)

    David W. Nigg, Principal Investigator; Kevin A. Steuhm, Project Manager

    2012-09-01

    Legacy computational reactor physics software tools and protocols currently used for support of Advanced Test Reactor (ATR) core fuel management and safety assurance, and to some extent, experiment management, are inconsistent with the state of modern nuclear engineering practice, and are difficult, if not impossible, to properly verify and validate (V&V) according to modern standards. Furthermore, the legacy staff knowledge required for application of these tools and protocols from the 1960s and 1970s is rapidly being lost due to staff turnover and retirements. In late 2009, the Idaho National Laboratory (INL) initiated a focused effort, the ATR Core Modeling Update Project, to address this situation through the introduction of modern high-fidelity computational software and protocols. This aggressive computational and experimental campaign will have a broad strategic impact on the operation of the ATR, both in terms of improved computational efficiency and accuracy for support of ongoing DOE programs as well as in terms of national and international recognition of the ATR National Scientific User Facility (NSUF). The ATR Core Modeling Update Project, targeted for full implementation in phase with the next anticipated ATR Core Internals Changeout (CIC) in the 2014-2015 time frame, began during the last quarter of Fiscal Year 2009, and has just completed its third full year. Key accomplishments so far have encompassed both computational as well as experimental work. A new suite of stochastic and deterministic transport theory based reactor physics codes and their supporting nuclear data libraries (HELIOS, KENO6/SCALE, NEWT/SCALE, ATTILA, and an extended implementation of MCNP5) has been installed at the INL under various licensing arrangements. Corresponding models of the ATR and ATRC are now operational with all five codes, demonstrating the basic feasibility of the new code packages for their intended purpose. Of particular importance, a set of as-run core

  6. Advanced Test Reactor Core Modeling Update Project Annual Report for Fiscal Year 2011

    International Nuclear Information System (INIS)

    Nigg, David W.; Steuhm, Devin A.

    2011-01-01

    Legacy computational reactor physics software tools and protocols currently used for support of Advanced Test Reactor (ATR) core fuel management and safety assurance and, to some extent, experiment management are obsolete, inconsistent with the state of modern nuclear engineering practice, and are becoming increasingly difficult to properly verify and validate (V and V). Furthermore, the legacy staff knowledge required for application of these tools and protocols from the 1960s and 1970s is rapidly being lost due to staff turnover and retirements. In 2009 the Idaho National Laboratory (INL) initiated a focused effort to address this situation through the introduction of modern high-fidelity computational software and protocols, with appropriate V and V, within the next 3-4 years via the ATR Core Modeling and Simulation and V and V Update (or 'Core Modeling Update') Project. This aggressive computational and experimental campaign will have a broad strategic impact on the operation of the ATR, both in terms of improved computational efficiency and accuracy for support of ongoing DOE programs as well as in terms of national and international recognition of the ATR National Scientific User Facility (NSUF). The ATR Core Modeling Update Project, targeted for full implementation in phase with the anticipated ATR Core Internals Changeout (CIC) in the 2014 time frame, began during the last quarter of Fiscal Year 2009, and has just completed its first full year. Key accomplishments so far have encompassed both computational as well as experimental work. A new suite of stochastic and deterministic transport theory based reactor physics codes and their supporting nuclear data libraries (SCALE, KENO-6, HELIOS, NEWT, and ATTILA) have been installed at the INL under various permanent sitewide license agreements and corresponding baseline models of the ATR and ATRC are now operational, demonstrating the basic feasibility of these code packages for their intended purpose

  7. Diagnostic pitfalls in a young Romanian ranger with an acute psychotic episode

    Directory of Open Access Journals (Sweden)

    Nagy EE

    2016-05-01

    Full Text Available Elöd Ernö Nagy,1,2 Attila Rácz,3 Edit Urbán,4 Gabriella Terhes,4 Timea Berki,5 Emöke Horváth,6 Anca M Georgescu,7 Iringó E Zaharia-Kézdi71Department of Pharmaceutical Biochemistry, University of Medicine and Pharmacy of Târgu-Mureş, 2Laboratory of Medical Analysis, Mures Clinical County Hospital, 3II. Psychiatry Clinic, Mures Clinical County Hospital, Târgu Mureş, Romania; 4Faculty of Medicine, Institute of Clinical Microbiology, University of Szeged, Szeged, 5Faculty of Medicine, Institute of Immunology and Biotechnology, University of Pécs, Pécs, Hungary; 6Department of Pathology, 7I. Clinic of Infectious Disease, University of Medicine and Pharmacy, Târgu Mureş, RomaniaAbstract: The identification and distinction of the pathological conditions underlying acute psychosis are often challenging. We present the case of a 35-year-old ranger who had no history of acute or chronic infectious disease or any previous neuropsychiatric symptoms. He arrived at the Psychiatry Clinic and was admitted as an emergency case, displaying bizarre behavior, hallucinations, paranoid ideation, and delusional faults. These symptoms had first appeared 7 days earlier. An objective examination revealed abnormalities of behavior, anxiety, visual hallucinations, choreiform, and tic-like facial movements. After the administration of neuroleptic and antidepressant treatment, he showed an initial improvement, but on day 10 entered into a severe catatonic state with signs of meningeal irritation and was transferred to the intensive care unit. An electroencephalogram showed diffuse irritative changes, raising the possibility of encephalitis. Taking into consideration the overt occupational risk, Borrelia antibody tests were prescribed and highly positive immunoglobulin (IgM and IgG titers were obtained from serum, along with IgG and antibody index positivity in cerebrospinal fluid. In parallel, anti-N-methyl-D-aspartate receptor antibodies and a whole

  8. St. Patrick's Day 2015 geomagnetic storm analysis based on Real Time Ionosphere Monitoring

    Science.gov (United States)

    García-Rigo, Alberto

    2017-04-01

    Alberto García-Rigo (1), David Roma-Dollase (2), Manuel Hernández-Pajares (1), Zishen Li (3), Michael Terkildsen (4), German Olivares (4), Reza Ghoddousi-Fard (5), Denise Dettmering (6), Eren Erdogan (6), Haris Haralambous (7), Yannick Béniguel (8), Jens Berdermann (9), Martin Kriegel (9), Anna Krypiak-Gregorczyk (10), Tamara Gulyaeva (11), Attila Komjathy (12), Panagiotis Vergados (12), Joachim Feltens (13,19), René Zandbergen (13), Tim Fuller-Rowell (14), David Altadill (15), Nicolas Bergeot (16), Andrzej Krankowski (17), Loukis Agrotis (18), Ivan Galkin (20), Raul Orus-Perez (21) 1. UPC-IonSAT research group, Technical University of Catalonia, Spain 2. Department of Engineering: Electronics, University of Barcelona (UB), Spain 3. Academy of Opto-Electronics, Chinese Academy of Sciences (CAS), China 4. Bureau of Meteorology, Space Weather Services, Australia 5. Canadian Geodetic Survey, Natural Resources Canada (NRCan) / Government of Canada, Canada 6. Deutsches Geodätisches Forschungsinstitut der Technischen Universität München (DGFI-TUM), Germany 7. Frederick University Cyprus, Cyprus 8. IEEA, France 9. Institute of Communications and Navigation, DLR, Germany 10. Institute of Geodesy, UWM, Poland 11. Institute of Terrestrial Magnetism, ionosphere and Radio Wave Propagation, Russian Academy of Sciences, Russia 12. NASA - Jet Propulsion Laboratory (JPL), California Institute of Technology, USA 13. Navigation Support Office, ESA-ESOC, Germany 14. NOAA affiliate, USA 15. Observatori de l'Ebre (OE), CSIC - Universitat Ramon Llull, 43520 Roquetes, Spain 16. Planetology and Reference Systems, Royal Observatory of Belgium (ROB), Belgium 17. Space Radio-Diagnostics Research Centre, UWM (SRRC/UWM), Poland 18. SYMBAN Limited, ESA-ESOC, Germany 19. Telespazio VEGA Deutschland GmbH c/o ESA-ESOC, Germany 20. University of Massachusetts Lowell, Space Science Lab, USA 21. Wave Interaction and Propagation Section (TEC-EEP), ESA-ESTEC, The Netherlands IAG's Real Time