WorldWideScience

Sample records for crack-driving forces investigated

  1. Crack Driving Forces in a Multilayered Coating System for Ceramic Matrix Composite Substrates

    Science.gov (United States)

    Ghosn, Louis J.; Zhu, Dongming; Miller, Robert A.

    2005-01-01

    The effects of the top coating thickness, modulus and shrinkage strains on the crack driving forces for a baseline multilayer Yttria-Stabilized-Zirconia/Mullite/Si thermal and environment barrier coating (TEBC) system for SiC/SiC ceramic matrix composite substrates are determined for gas turbine applications. The crack driving forces increase with increasing modulus, and a low modulus thermal barrier coating material (below 10 GPa) will have no cracking issues under the thermal gradient condition analyzed. Since top coating sintering increases the crack driving forces with time, highly sintering resistant coatings are desirable to maintain a low tensile modulus and maintain a low crack driving force with time. Finite element results demonstrated that an advanced TEBC system, such as ZrO2/HfO2, which possesses improved sintering resistance and high temperature stability, exhibited excellent durability. A multi-vertical cracked structure with fine columnar spacing is an ideal strain tolerant coating capable of reducing the crack driving forces to an acceptable level even with a high modulus of 50 GPa.

  2. Investigation of Calibrating Force Transducer Using Sinusoidal Force

    International Nuclear Information System (INIS)

    Zhang Li; Wang Yu; Zhang Lizhe

    2010-01-01

    Sinusoidal force calibration method was studied several years before at Physikalisch-Technische Bundesanstalt (PTB). A similar dynamic force calibration system is developed at Changcheng Institute of Metrology and Measurement (CIMM). It uses electro-dynamic shakers to generate dynamic force in the range from 1 N to 20 kN, and heterodyne laser interferometers are used for acceleration measurement. The force transducer to be calibrated is mounted on the shaker, and a mass block is screwed on the top of force transducer, the sinusoidal forces realized by accelerated load masses are traceable to acceleration and mass according to the force definition. The methods of determining Spatial-dependent acceleration on mass block and measuring the end mass of force transducer in dynamic force calibration are discussed in this paper.

  3. Physics investigate the forces of nature

    CERN Document Server

    Gardner, Jane

    2014-01-01

    Have you ever noticed that the physical world works in certain ways? Skateboarders use force and motion to perform tricks. If you jump up as high as you can, you'll quickly fall back to the ground. Baseball players use gravity to bring the ball back down when they throw it. When you flip a switch, electricity powers your toaster. Rock bands use electricity to put on a show. The fascinating science of physics helps you understand why forces, motion, gravity, electricity, light, and sound work in predictable ways. Combining inquiry-based activities with physics topics, Physics: Investigate the Forces of Nature features graphic novel illustrations, fascinating sidebars, youtube links, and a glossary of important vocabulary to illuminate the complex world of physics and bring it to life. Projects include designing a skateboard park that maps the forces at work on the skateboarder and the skateboard, and creating a stage design for a rock band that places electric current where it is needed. Additional materials i...

  4. Investigating bioconjugation by atomic force microscopy

    Science.gov (United States)

    2013-01-01

    Nanotechnological applications increasingly exploit the selectivity and processivity of biological molecules. Integration of biomolecules such as proteins or DNA into nano-systems typically requires their conjugation to surfaces, for example of carbon-nanotubes or fluorescent quantum dots. The bioconjugated nanostructures exploit the unique strengths of both their biological and nanoparticle components and are used in diverse, future oriented research areas ranging from nanoelectronics to biosensing and nanomedicine. Atomic force microscopy imaging provides valuable, direct insight for the evaluation of different conjugation approaches at the level of the individual molecules. Recent technical advances have enabled high speed imaging by AFM supporting time resolutions sufficient to follow conformational changes of intricately assembled nanostructures in solution. In addition, integration of AFM with different spectroscopic and imaging approaches provides an enhanced level of information on the investigated sample. Furthermore, the AFM itself can serve as an active tool for the assembly of nanostructures based on bioconjugation. AFM is hence a major workhorse in nanotechnology; it is a powerful tool for the structural investigation of bioconjugation and bioconjugation-induced effects as well as the simultaneous active assembly and analysis of bioconjugation-based nanostructures. PMID:23855448

  5. Comparative investigations of tablet crushing force testers

    DEFF Research Database (Denmark)

    Sonnergaard, Jørn; Jensen, C.G.; Poulsen, L.

    2005-01-01

    The performance of 16 tablet breaking force testers was evaluated in terms of accuracy, reproducibility and repeatability. Three tablet formulations with different plastic or brittle deformation mechanisms and with target breaking forces of 50, 100 and 150 N were tested. Statistically significant...... by the concept of components of variance was 5-7 % depending on the model tablet excipient. The standard deviation within testers (repeatability) was affected by the type of model formulation showing increasing variability with increasing brittleness of the compressed material. No specific effect of altering...

  6. Experimental investigation of turbine blade-tip excitation forces

    Science.gov (United States)

    Martinez-Sanchez, Manuel; Jaroux, Belgacem; Song, Seung Jin; Yoo, Soom-Yung; Palczynski, Taras

    1994-01-01

    Results of a program to investigate the magnitude and parametric variations of rotordynamic forces which arise in high power turbines due to blade-tip leakage effects are presented. Five different unshrouded turbine configurations and one configuration shrouded with a labyrinth seal were tested with static offsets of the turbine shaft. The forces along and perpendicular to the offset were measured directly with a rotating dynometer. Exploration of casing pressure and flow velocity distributions was used to investigate the force-generating mechanisms. For unshrouded turbines, the cross-forces originate mainly from the classical Alford mechanisms while the direct forces arise mainly from a slightly skewed pressure pattern. The Alford coefficient for cross-force was found to vary between 2.4 and 4.0, while the similar direct force coefficient varied from 1.5 to 3.5. The cross-forces are found to increase substantially when the gap is reduced from 3.0 to 1.9% of blade height, probably due to viscous blade-tip effects. The forces also increase when the hub gap between stator and rotor decreases. The force coefficient decreased with operating flow coefficient. In the case of the shrouded turbine, most of the forces arise from nonuniform seal pressures. This includes about 80% for the transverse forces. The rest appears to come from uneven work extraction. Their level is about 50% higher in the shrouded case.

  7. Investigation of dissipative forces near macroscopic media

    International Nuclear Information System (INIS)

    Becker, R.S.

    1982-12-01

    The interaction of classical charged particles with the fields they induce in macroscopic dielectric media is investigated. For 10- to 1000-eV electrons, the angular perturbation of the trajectory by the image potential for surface impact parameters of 50 to 100 A is shown to be of the order of 0.001 rads over a distance of 100 A. The energy loss incurred by low-energy particles due to collective excitations such as surface plasmons is shown to be observable with a transition probability of 0.01 to 0.001 (Becker, et al., 1981b). The dispersion of real surface plasmon modes in planar and cylindrical geometries is discussed and is derived for pinhole geometry described in terms of a single-sheeted hyperboloid of revolution. An experimental apparatus for the measurement of collective losses for medium-energy electrons translating close to a dielectric surface is described and discussed. Data showing such losses at electron energies of 500 to 900 eV in silver foils containing many small apertures are presented and shown to be in good agreement with classical stopping power calculations and quantum mechanical calculations carried out in the low-velocity limit. The data and calculations are compared and contrasted with earlier transmission and reflection measurements, and the course of further investigation is discussed

  8. Pilot investigation - Nominal crew induced forces in zero-g

    Science.gov (United States)

    Klute, Glenn K.

    1992-01-01

    This report presents pilot-study data of test subject forces induced by intravehicular activities such as push-offs and landings with both hands and feet. Five subjects participated in this investigation. Three orthogonal force axes were measured in the NASA KC-135 research aircraft's 'zero-g' environment. The largest forces were induced during vertical foot push-offs, including one of 534 newtons (120 lbs). The mean vertical foot push-off was 311 newtons (70 lbs). The vertical hand push-off forces were also relatively large, including one of 267 newtons (60 lbs) with a mean of 151 newtons (34 lbs). These force magnitudes of these forces would result in a Shuttle gravity environment of about 1 x exp 10 -4 g's.

  9. Investigations on pneumatically forced-actuated compressor valves

    Science.gov (United States)

    Stöckel, Christian; Thomas, Christiane; Nickl, Jörg; Hesse, Ullrich

    2017-08-01

    In the present paper the performance of a novel designed valve for reciprocating piston machines is investigated, which makes existing compressors utilizable for operating as expander. Three design parameters were identified as critical for the valves performance particularly in forced actuated mode. Within a numerical simulation a study on the crucial geometrical parameters, the influence could be observed. Afterwards the experimental setup for the integral test of the valve design is presented and also additional tests for single valve components.

  10. Multifarious applications of atomic force microscopy in forensic science investigations.

    Science.gov (United States)

    Pandey, Gaurav; Tharmavaram, Maithri; Rawtani, Deepak; Kumar, Sumit; Agrawal, Y

    2017-04-01

    Forensic science is a wide field comprising of several subspecialties and uses methods derived from natural sciences for finding criminals and other evidence valid in a legal court. A relatively new area; Nano-forensics brings a new era of investigation in forensic science in which instantaneous results can be produced that determine various agents such as explosive gasses, biological agents and residues in different crime scenes and terrorist activity investigations. This can be achieved by applying Nanotechnology and its associated characterization techniques in forensic sciences. Several characterization techniques exist in Nanotechnology and nano-analysis is one such technique that is used in forensic science which includes Electron microscopes (EM) like Transmission (TEM) and Scanning (SEM), Raman microscopy (Micro -Raman) and Scanning Probe Microscopes (SPMs) like Atomic Force Microscope (AFM). Atomic force microscopy enables surface characterization of different materials by examining their morphology and mechanical properties. Materials that are immeasurable such as hair, body fluids, textile fibers, documents, polymers, pressure sensitive adhesives (PSAs), etc. are often encountered during forensic investigations. This review article will mainly focus on the use of AFM in the examination of different evidence such as blood stains, forged documents, human hair samples, ammunitions, explosives, and other such applications in the field of Forensic Science. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Dynamic force profile in hydraulic hybrid vehicles: a numerical investigation

    Science.gov (United States)

    Mohaghegh-Motlagh, Amin; Elahinia, Mohammad H.

    2010-04-01

    A hybrid hydraulic vehicle (HHV) combines a hydraulic sub-system with the conventional drivetrain in order to improve fuel economy for heavy vehicles. The added hydraulic module manages the storage and release of fluid power necessary to assist the motion of the vehicle. The power collected by a pump/motor (P/M) from the regenerative braking phase is stored in a high-pressure accumulator and then released by the P/M to the driveshaft during the acceleration phase. This technology is effective in significantly improving fuel-economy for heavy-class vehicles with frequent stop-and-go drive schedules. Despite improved fuel economy and higher vehicle acceleration, noise and vibrations are one of the main problems of these vehicles. The dual function P/Ms are the main source of noise and vibration in a HHV. This study investigates the dynamics of a P/M and particularly the profile and frequency-dependence of the dynamic forces generated by a bent-axis P/M unit. To this end, the fluid dynamics side of the problem has been simplified for investigating the system from a dynamics perspective. A mathematical model of a bent axis P/M has been developed to investigate the cause of vibration and noise in HHVs. The forces are calculated in time and frequency domains. The results of this work can be used to study the vibration response of the chassis and to design effective vibration isolation systems for HHVs.

  12. Investigations on cooling with forced flow of He II

    International Nuclear Information System (INIS)

    Srinivasan, R.; Hofmann, A.

    1985-01-01

    Investigations on heat transfer to flowing subcooled He II at a pressure of 7 bar have been carried out. The value of the conductivity function, f(T), at a temperature greater than Tsub(max), drops rapidly with increasing pressure. Below Tsub(max) the change in f(T) with pressure is less drastic. The Gorter-Mellink constant Asub(GM), increases linearly with pressure in the range 1.5-2 K and its pressure coefficient at 1 bar is 0.038+-0.01 per bar, independent of temperature. The temperature distribution in the test section with and without flow is adequately described by the one-dimensional model discussed in Part 1. It is concluded that for heat transfer to He II in forced flow there is no advantage in working at pressures > 1 bar. (author)

  13. Investigation of polyelectrolyte desorption by single molecule force spectroscopy

    International Nuclear Information System (INIS)

    Friedsam, C; Seitz, M; Gaub, H E

    2004-01-01

    Single molecule force spectroscopy has evolved into a powerful method for the investigation of intra- and intermolecular interactions at the level of individual molecules. Many examples, including the investigation of the dynamic properties of complex biological systems as well as the properties of covalent bonds or intermolecular transitions within individual polymers, are reported in the literature. The technique has recently been extended to the systematic investigation of desorption processes of individual polyelectrolyte molecules adsorbed on generic surfaces. The stable covalent attachment of polyelectrolyte molecules to the AFM-tip provides the possibility of performing long-term measurements with the same set of molecules and therefore allows the in situ observation of the impact of environmental changes on the adsorption behaviour of individual molecules. Different types of interactions, e.g. electrostatic or hydrophobic interactions, that determine the adsorption process could be identified and characterized. The experiments provided valuable details that help to understand the nature and the properties of non-covalent interactions, which is helpful with regard to biological systems as well as for technical applications. Apart from this, desorption experiments can be utilized to characterize the properties of surfaces or polymer coatings. Therefore they represent a versatile tool that can be further developed in terms of various aspects

  14. Atomic force microscopy investigation of the giant mimivirus

    International Nuclear Information System (INIS)

    Kuznetsov, Yuri G.; Xiao Chuan; Sun Siyang; Raoult, Didier; Rossmann, Michael; McPherson, Alexander

    2010-01-01

    Mimivirus was investigated by atomic force microscopy in its native state following serial degradation by lysozyme and bromelain. The 750-nm diameter virus is coated with a forest of glycosylated protein fibers of lengths about 140 nm with diameters 1.4 nm. Fibers are capped with distinctive ellipsoidal protein heads of estimated Mr = 25 kDa. The surface fibers are attached to the particle through a layer of protein covering the capsid, which is in turn composed of the major capsid protein (MCP). The latter is organized as an open network of hexagonal rings with central depressions separated by 14 nm. The virion exhibits an elaborate apparatus at a unique vertex, visible as a star shaped depression on native particles, but on defibered virions as five arms of 50 nm width and 250 nm length rising above the capsid by 20 nm. The apparatus is integrated into the capsid and not applied atop the icosahedral lattice. Prior to DNA release, the arms of the star disengage from the virion and it opens by folding back five adjacent triangular faces. A membrane sac containing the DNA emerges from the capsid in preparation for fusion with a membrane of the host cell. Also observed from disrupted virions were masses of distinctive fibers of diameter about 1 nm, and having a 7-nm periodicity. These are probably contained within the capsid along with the DNA bearing sac. The fibers were occasionally observed associated with toroidal protein clusters interpreted as processive enzymes modifying the fibers.

  15. Low temperature corneal laser welding investigated by atomic force microscopy

    Science.gov (United States)

    Matteini, Paolo; Sbrana, Francesca; Tiribilli, Bruno; Pini, Roberto

    2009-02-01

    The structural modifications in the stromal matrix induced by low-temperature corneal laser welding were investigated by atomic force microscopy (AFM). This procedure consists of staining the wound with Indocyanine Green (ICG), followed by irradiation with a near-infrared laser operated at low-power densities. This induces a local heating in the 55-65 °C range. In welded tissue, extracellular components undergo heat-induced structural modifications, resulting in a joining effect between the cut edges. However, the exact mechanism generating the welding, to date, is not completely understood. Full-thickness cuts, 3.5 mm in length, were made in fresh porcine cornea samples, and these were then subjected to laser welding operated at 16.7 W/cm2 power density. AFM imaging was performed on resin-embedded semi-thin slices once they had been cleared by chemical etching, in order to expose the stromal bulk of the tissue within the section. We then carried out a morphological analysis of characteristic fibrillar features in the laser-treated and control samples. AFM images of control stromal regions highlighted well-organized collagen fibrils (36.2 +/- 8.7 nm in size) running parallel to each other as in a typical lamellar domain. The fibrils exhibited a beaded pattern with a 22-39 nm axial periodicity. Laser-treated corneal regions were characterized by a significant disorganization of the intralamellar architecture. At the weld site, groups of interwoven fibrils joined the cut edges, showing structural properties that were fully comparable with those of control regions. This suggested that fibrillar collagen is not denatured by low-temperature laser welding, confirming previous transmission electron microscopy (TEM) observations, and thus it is probably not involved in the closure mechanism of corneal cuts. The loss of fibrillar organization may be related to some structural modifications in some interfibrillar substance as proteoglycans or collagen VI. Furthermore, AFM

  16. Chromosome structure investigated with the atomic force microscope

    NARCIS (Netherlands)

    de Grooth, B.G.; Putman, C.A.J.; Putman, Constant A.; van der Werf, Kees; van Hulst, N.F.; van Oort, G.; van Oort, Geeske; Greve, Jan; Manne, Srinivas

    1992-01-01

    We have developed an atomic force microscope (AFM) with an integrated optical microscope. The optical microscope consists of an inverted epi-illumination system that yields images in reflection or fluorescence of the sample. With this system it is possible to quickly locate an object of interest. A

  17. Drag force and jet propulsion investigation of a swimming squid

    Directory of Open Access Journals (Sweden)

    Tabatabaei Mahdi

    2015-01-01

    Full Text Available In this study, CAD model of a squid was obtained by taking computer tomography images of a real squid. The model later placed into a computational domain to calculate drag force and performance of jet propulsion. The drag study was performed on the CAD model so that drag force subjected to real squid was revealed at squid’s different swimming speeds and comparison has been made with other underwater creatures (e.g., a dolphin, sea lion and penguin. The drag coefficient (referenced to total wetted surface area of squid is 0.0042 at Reynolds number 1.6x106 that is a %4.5 difference from Gentoo penguin. Besides, jet flow of squid was simulated to observe the flow region generated in the 2D domain utilizing dynamic mesh method to mimic the movement of squid’s mantle cavity.

  18. An Investigation of the Posterior Component of Occlusal Force

    Science.gov (United States)

    1994-05-01

    into factors which can contribute to and/or modify bite force. Corrucini et al (1985) reported differences between mouth breathers (diagnosed on history ...both of those factors to be associated with facial morphology. Ingervall et al diagnosed mouth breathing based upon history , rhinomanometrically...that, in normal physiologic function, the dentition is loaded from many directions in addition to purely from an axial direction. Paranormal habits and

  19. Investigating single molecule adhesion by atomic force spectroscopy.

    Science.gov (United States)

    Stetter, Frank W S; Kienle, Sandra; Krysiak, Stefanie; Hugel, Thorsten

    2015-02-27

    Atomic force spectroscopy is an ideal tool to study molecules at surfaces and interfaces. An experimental protocol to couple a large variety of single molecules covalently onto an AFM tip is presented. At the same time the AFM tip is passivated to prevent unspecific interactions between the tip and the substrate, which is a prerequisite to study single molecules attached to the AFM tip. Analyses to determine the adhesion force, the adhesion length, and the free energy of these molecules on solid surfaces and bio-interfaces are shortly presented and external references for further reading are provided. Example molecules are the poly(amino acid) polytyrosine, the graft polymer PI-g-PS and the phospholipid POPE (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine). These molecules are desorbed from different surfaces like CH3-SAMs, hydrogen terminated diamond and supported lipid bilayers under various solvent conditions. Finally, the advantages of force spectroscopic single molecule experiments are discussed including means to decide if truly a single molecule has been studied in the experiment.

  20. Force Concept Inventory-Based Multiple-Choice Test for Investigating Students' Representational Consistency

    Science.gov (United States)

    Nieminen, Pasi; Savinainen, Antti; Viiri, Jouni

    2010-01-01

    This study investigates students' ability to interpret multiple representations consistently (i.e., representational consistency) in the context of the force concept. For this purpose we developed the Representational Variant of the Force Concept Inventory (R-FCI), which makes use of nine items from the 1995 version of the Force Concept Inventory…

  1. Theoretical and Experimental Investigation of Force Estimation Errors Using Active Magnetic Bearings with Embedded Hall Sensors

    DEFF Research Database (Denmark)

    Voigt, Andreas Jauernik; Santos, Ilmar

    2012-01-01

    to ∼ 20% of the nominal air gap the force estimation error is found to be reduced by the linearized force equation as compared to the quadratic force equation, which is supported by experimental results. Additionally the FE model is employed in a comparative study of the force estimation error behavior...... of AMBs by embedding Hall sensors instead of mounting these directly on the pole surfaces, force estimation errors are investigated both numerically and experimentally. A linearized version of the conventionally applied quadratic correspondence between measured Hall voltage and applied AMB force...

  2. Electrostatic characteristics of nanostructures investigated using electric force microscopy

    International Nuclear Information System (INIS)

    Qiu, X.H.; Qi, G.C.; Yang, Y.L.; Wang, C.

    2008-01-01

    Nanosized materials possess many interesting physical and chemical properties that differ significantly from their macroscopic counterparts. Understanding the size- and shape-dependent properties of nanostructures are of great value to rational design of nanomaterials with desired functionality. Electric force microscopy (EFM) and its variations offer unique opportunities to deepen our insights into the electrical characteristics of nanostructures. In this paper, we review recent progress of this versatile technique and its applications in studying the electrical properties of nanosized materials. A variety of important issues in EFM experimentation and theoretical modeling are discussed, with an emphasis on the ongoing efforts to improve the precision in quantitative measurements of charge density and dielectric properties of nanostructures. - Graphical abstract: We review recent progress of electric force microscopy (EFM) and its applications in studying the electrical properties of nanostructures. A variety of important issues in EFM experimentation and theoretical modeling are discussed, with an emphasis on the ongoing efforts to improve the precision in quantitative measurements of charge density and dielectric properties of nanostructures

  3. Task Force to Improve Timeliness of Senior Official Administrative Investigations

    Science.gov (United States)

    2014-11-04

    of Staff of the Army, or The Inspector General ( TIG ). When directed, DAIG-IN conducts investigations of systemic issues affecting the Army. The...develop the investigative plan. TIG and/or Deputy TIG notify the subject(s), rater, and senior rater of the investigation and provide the general nature...officers and SES equivalents. TIG approves all substantiated cases regardless of rank. DoD OIG Oversight After the Office of The Inspector General

  4. Surface structure investigations using noncontact atomic force microscopy

    International Nuclear Information System (INIS)

    Kolodziej, J.J.; Such, B.; Goryl, M.; Krok, F.; Piatkowski, P.; Szymonski, M.

    2006-01-01

    Surfaces of several A III B V compound semiconductors (InSb, GaAs, InP, InAs) of the (0 0 1) orientation have been studied with noncontact atomic force microscopy (NC-AFM). Obtained atomically resolved patterns have been compared with structural models available in the literature. It is shown that NC-AFM is an efficient tool for imaging complex surface structures in real space. It is also demonstrated that the recent structural models of III-V compound surfaces provide a sound base for interpretation of majority of features present in recorded patterns. However, there are also many new findings revealed by the NC-AFM method that is still new experimental technique in the context of surface structure determination

  5. A flight investigation of oscillating air forces: Equipment and technique

    Science.gov (United States)

    Reed, W. H., III

    1975-01-01

    The equipment and techniques are described which are to be used in a project aimed at measuring oscillating air forces and dynamic aeroelastic response of a swept wing airplane at high subsonic speeds. Electro-hydraulic inertia type shakers installed in the wing tips will excite various elastic airplane modes while the related oscillating chordwise pressures at two spanwise wing stations and the wing mode shapes are recorded on magnetic tape. The data reduction technique, following the principle of a wattmeter harmonic analyzer employed by Bratt, Wight, and Tilly, utilizes magnetic tape and high speed electronic multipliers to record directly the real and imaginary components of oscillatory data signals relative to a simple harmonic reference signal. Through an extension of this technique an automatic flight-flutter-test data analyzer is suggested in which vector plots of mechanical admittance or impedance would be plotted during the flight test.

  6. Further investigation on "A multiplicative regularization for force reconstruction"

    Science.gov (United States)

    Aucejo, M.; De Smet, O.

    2018-05-01

    We have recently proposed a multiplicative regularization to reconstruct mechanical forces acting on a structure from vibration measurements. This method does not require any selection procedure for choosing the regularization parameter, since the amount of regularization is automatically adjusted throughout an iterative resolution process. The proposed iterative algorithm has been developed with performance and efficiency in mind, but it is actually a simplified version of a full iterative procedure not described in the original paper. The present paper aims at introducing the full resolution algorithm and comparing it with its simplified version in terms of computational efficiency and solution accuracy. In particular, it is shown that both algorithms lead to very similar identified solutions.

  7. Investigation of electrostatic force and dipole moment effects on ...

    African Journals Online (AJOL)

    An understanding of static properties of membrane is an essential prelude to the study of movement of molecules within the membrane. In this investigation any molecule has been theoretically investigated through the quantum mechanical calculations.According to the results obtained, the structural optimization of the ...

  8. Investigation of slightly forced buoyant flow in a training reactor

    International Nuclear Information System (INIS)

    Legradi, G.; Aszodi, A.; Por, G.

    2001-01-01

    A measurement based on the temperature noise analysis method was carried out in the Training Reactor of the Budapest University of Technology and Economics. The main goals were the estimation of the flow velocity immediately above the reactor core and investigation of the thermal-hydraulical conditions of the reactor, mainly in the core. Subsequently 2D and 3D computations were carried out with the aid of the code CFX- 4.3. The main objective of the 2D calculation was to clarify the thermal-hydraulical conditions of the whole reactor tank with a reasonable computing demand. It was also necessary to accomplish 3D numerical investigations of the reactor core and the space above since three dimensional effects of the flow could only be studied in this way. In addition, obtaining certain boundary conditions of the 3D computations was another significant aim of the 2D investigations. It is important that the results of the noise analysis and the operational measuring system of the reactor gave us a basis for verifying our computations.(author)

  9. Investigations on the Effects of Vortex-Induced Vibration with Different Distributions of Lorentz Forces

    Directory of Open Access Journals (Sweden)

    Hui Zhang

    2017-01-01

    Full Text Available The control of vortex-induced vibration (VIV in shear flow with different distributions of Lorentz force is numerically investigated based on the stream function–vorticity equations in the exponential-polar coordinates exerted on moving cylinder for Re = 150. The cylinder motion equation coupled with the fluid, including the mathematical expressions of the lift force coefficient C l , is derived. The initial and boundary conditions as well as the hydrodynamic forces on the surface of cylinder are also formulated. The Lorentz force applied to suppress the VIV has no relationship with the flow field, and involves two categories, i.e., the field Lorentz force and the wall Lorentz force. With the application of symmetrical Lorentz forces, the symmetric field Lorentz force can amplify the drag, suppress the flow separation, decrease the lift fluctuation, and then suppress the VIV while the wall Lorentz force decreases the drag only. With the application of asymmetrical Lorentz forces, besides the above-mentioned effects, the field Lorentz force can increase additional lift induced by shear flow, whereas the wall Lorentz force can counteract the additional lift, which is dominated on the total effect.

  10. A Modeling Framework to Investigate the Radial Component of the Pushrim Force in Manual Wheelchair Propulsion

    Directory of Open Access Journals (Sweden)

    Ackermann Marko

    2015-01-01

    Full Text Available The ratio of tangential to total pushrim force, the so-called Fraction Effective Force (FEF, has been used to evaluate wheelchair propulsion efficiency based on the fact that only the tangential component of the force on the pushrim contributes to actual wheelchair propulsion. Experimental studies, however, consistently show low FEF values and recent experimental as well as modelling investigations have conclusively shown that a more tangential pushrim force direction can lead to a decrease and not increase in propulsion efficiency. This study aims at quantifying the contributions of active, inertial and gravitational forces to the normal pushrim component. In order to achieve this goal, an inverse dynamics-based framework is proposed to estimate individual contributions to the pushrim forces using a model of the wheelchair-user system. The results show that the radial pushrim force component arise to a great extent due to purely mechanical effects, including inertial and gravitational forces. These results corroborate previous findings according to which radial pushrim force components are not necessarily a result of inefficient propulsion strategies or hand-rim friction requirements. This study proposes a novel framework to quantify the individual contributions of active, inertial and gravitational forces to pushrim forces during wheelchair propulsion.

  11. Predicting wind farm wake interaction with RANS: an investigation of the Coriolis force

    DEFF Research Database (Denmark)

    van der Laan, Paul; Hansen, Kurt Schaldemose; Sørensen, Niels N.

    2015-01-01

    A Reynolds-averaged Navier-Stokes code is used to simulate the interaction of two neighboring wind farms. The influence of the Coriolis force is investigated by modeling the atmospheric surface/boundary layer with three different methodologies. The results show that the Coriolis force is negligible...

  12. Project Portfolio Management: An Investigation of One Air Force Product Center

    National Research Council Canada - National Science Library

    Edmunds, Bryan D

    2005-01-01

    .... This research focuses on the portfolio management (project selection and resource allocation) part of the CTRRP. The purpose of this research effort was to investigate the use of portfolio management within the Air Force...

  13. Investigation of a mutual interaction force at different pressure amplitudes in sulfuric acid

    International Nuclear Information System (INIS)

    Rezaee, Nastaran; Sadighi-Bonabi, Rasoul; Mirheydari, Mona; Ebrahimi, Homa

    2011-01-01

    This paper investigates the secondary Bjerknes force for two oscillating bubbles in various pressure amplitudes in a concentration of 95% sulfuric acid. The equilibrium radii of the bubbles are assumed to be smaller than 10 μm at a frequency of 37 kHz in various strong driving acoustical fields around 2.0 bars (1 bar=10 5 Pa). The secondary Bjerknes force is investigated in uncoupled and coupled states between the bubbles, with regard to the quasi-adiabatic model for the bubble interior. It finds that the value of the secondary Bjerknes force depends on the driven pressure of sulfuric acid and its amount would be increased by liquid pressure amplitude enhancement. The results show that the repulsion area of the interaction force would be increased by increasing the driven pressure because of nonlinear oscillation of bubbles. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

  14. Supplemental site inspection for Air Force Plant 59, Johnson City, New York, Volume 1: Investigation report

    Energy Technology Data Exchange (ETDEWEB)

    Nashold, B.; Rosenblatt, D.; Hau, J. [and others

    1995-08-01

    This summary describes a Supplemental Site Inspection (SSI) conducted by Argonne National Laboratory (ANL) at Air Force Plant 59 (AFP 59) in Johnson City, New York. All required data pertaining to this project were entered by ANL into the Air Force-wide Installation Restoration Program Information System (IRPIMS) computer format and submitted to an appropriate authority. The work was sponsored by the United States Air Force as part of its Installation Restoration Program (IRP). Previous studies had revealed the presence of contaminants at the site and identified several potential contaminant sources. Argonne`s study was conducted to answer questions raised by earlier investigations.

  15. Source evaluation report phase 2 investigation: Limited field investigation. Final report: United States Air Force Environmental Restoration Program, Eielson Air Force Base, Alaska

    Energy Technology Data Exchange (ETDEWEB)

    1994-10-01

    This report describes the limited field investigation work done to address issues and answer unresolved questions regarding a collection of potential contaminant sources at Eielson Air Force Base (AFB), near Fairbanks, Alaska. These sources were listed in the Eielson AFB Federal Facility Agreement supporting the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) cleanup of the base. The limited field investigation began in 1993 to resolve all remaining technical issues and provide the data and analysis required to evaluate the environmental hazard associated with these sites. The objective of the limited field investigation was to allow the remedial project managers to sort each site into one of three categories: requiring remedial investigation/feasibility study, requiring interim removal action, or requiring no further remedial action.

  16. Atomic force microscopy as a tool for the investigation of living cells.

    Science.gov (United States)

    Morkvėnaitė-Vilkončienė, Inga; Ramanavičienė, Almira; Ramanavičius, Arūnas

    2013-01-01

    Atomic force microscopy is a valuable and useful tool for the imaging and investigation of living cells in their natural environment at high resolution. Procedures applied to living cell preparation before measurements should be adapted individually for different kinds of cells and for the desired measurement technique. Different ways of cell immobilization, such as chemical fixation on the surface, entrapment in the pores of a membrane, or growing them directly on glass cover slips or on plastic substrates, result in the distortion or appearance of artifacts in atomic force microscopy images. Cell fixation allows the multiple use of samples and storage for a prolonged period; it also increases the resolution of imaging. Different atomic force microscopy modes are used for the imaging and analysis of living cells. The contact mode is the best for cell imaging because of high resolution, but it is usually based on the following: (i) image formation at low interaction force, (ii) low scanning speed, and (iii) usage of "soft," low resolution cantilevers. The tapping mode allows a cell to behave like a very solid material, and destructive shear forces are minimized, but imaging in liquid is difficult. The force spectroscopy mode is used for measuring the mechanical properties of cells; however, obtained results strongly depend on the cell fixation method. In this paper, the application of 3 atomic force microscopy modes including (i) contact, (ii) tapping, and (iii) force spectroscopy for the investigation of cells is described. The possibilities of cell preparation for the measurements, imaging, and determination of mechanical properties of cells are provided. The applicability of atomic force microscopy to diagnostics and other biomedical purposes is discussed.

  17. A clinical investigation of force delivery systems for orthodontic space closure.

    Science.gov (United States)

    Nightingale, C; Jones, S P

    2003-09-01

    To investigate the force retention, and rates of space closure achieved by elastomeric chain and nickel titanium coil springs. Randomized clinical trial. Eastman Dental Hospital, London and Queen Mary's University Hospital, Roehampton, 1998-2000. Twenty-two orthodontic patients, wearing the pre-adjusted edgewise appliance undergoing space closure in opposing quadrants, using sliding mechanics on 0.019 x 0.025-inch posted stainless steel archwires. Medium-spaced elastomeric chain [Durachain, OrthoCare (UK) Ltd., Bradford, UK] and 9-mm nickel titanium coil springs [OrthoCare (UK) Ltd.] were placed in opposing quadrants for 15 patients. Elastomeric chain only was used in a further seven patients. The initial forces on placement and residual forces at the subsequent visit were measured with a dial push-pull gauge [Orthocare (UK) Ltd]. Study models of eight patients were taken before and after space closure, from which measurements were made to establish mean space closure. The forces were measured in grammes and space closure in millimetres. Fifty-nine per cent (31/53) of the elastomeric sample maintained at least 50 per cent of the initial force over a time period of 1-15 weeks. No sample lost all its force, and the mean loss was 47 per cent (range: 0-76 per cent). Nickel titanium coil springs lost force rapidly over 6 weeks, following that force levels plateaued. Forty-six per cent (12/26) maintained at least 50 per cent of their initial force over a time period of 1-22 weeks, and mean force loss was 48 per cent (range: 12-68 per cent). The rate of mean weekly space closure for elastomeric chain was 0.21 mm and for nickel titanium coil springs 0.26 mm. There was no relationship between the initial force applied and rate of space closure. None of the sample failed during the study period giving a 100 per cent response rate. In clinical use, the force retention of elastomeric chain was better than previously concluded. High initial forces resulted in high force decay

  18. Polyphilic Interactions as Structural Driving Force Investigated by Molecular Dynamics Simulation (Project 7

    Directory of Open Access Journals (Sweden)

    Christopher Peschel

    2017-09-01

    Full Text Available We investigated the effect of fluorinated molecules on dipalmitoylphosphatidylcholine (DPPC bilayers by force-field molecular dynamics simulations. In the first step, we developed all-atom force-field parameters for additive molecules in membranes to enable an accurate description of those systems. On the basis of this force field, we performed extensive simulations of various bilayer systems containing different additives. The additive molecules were chosen to be of different size and shape, and they included small molecules such as perfluorinated alcohols, but also more complex molecules. From these simulations, we investigated the structural and dynamic effects of the additives on the membrane properties, as well as the behavior of the additive molecules themselves. Our results are in good agreement with other theoretical and experimental studies, and they contribute to a microscopic understanding of interactions, which might be used to specifically tune membrane properties by additives in the future.

  19. Investigation of adhesion and mechanical properties of human glioma cells by single cell force spectroscopy and atomic force microscopy.

    Science.gov (United States)

    Andolfi, Laura; Bourkoula, Eugenia; Migliorini, Elisa; Palma, Anita; Pucer, Anja; Skrap, Miran; Scoles, Giacinto; Beltrami, Antonio Paolo; Cesselli, Daniela; Lazzarino, Marco

    2014-01-01

    Active cell migration and invasion is a peculiar feature of glioma that makes this tumor able to rapidly infiltrate into the surrounding brain tissue. In our recent work, we identified a novel class of glioma-associated-stem cells (defined as GASC for high-grade glioma--HG--and Gasc for low-grade glioma--LG) that, although not tumorigenic, act supporting the biological aggressiveness of glioma-initiating stem cells (defined as GSC for HG and Gsc for LG) favoring also their motility. Migrating cancer cells undergo considerable molecular and cellular changes by remodeling their cytoskeleton and cell interactions with surrounding environment. To get a better understanding about the role of the glioma-associated-stem cells in tumor progression, cell deformability and interactions between glioma-initiating stem cells and glioma-associated-stem cells were investigated. Adhesion of HG/LG-cancer cells on HG/LG-glioma-associated stem cells was studied by time-lapse microscopy, while cell deformability and cell-cell adhesion strengths were quantified by indentation measurements by atomic force microscopy and single cell force spectroscopy. Our results demonstrate that for both HG and LG glioma, cancer-initiating-stem cells are softer than glioma-associated-stem cells, in agreement with their neoplastic features. The adhesion strength of GSC on GASC appears to be significantly lower than that observed for Gsc on Gasc. Whereas, GSC spread and firmly adhere on Gasc with an adhesion strength increased as compared to that obtained on GASC. These findings highlight that the grade of glioma-associated-stem cells plays an important role in modulating cancer cell adhesion, which could affect glioma cell migration, invasion and thus cancer aggressiveness. Moreover this work provides evidence about the importance of investigating cell adhesion and elasticity for new developments in disease diagnostics and therapeutics.

  20. Investigation of index finger triggering force using a cadaver experiment: Effects of trigger grip span, contact location, and internal tendon force.

    Science.gov (United States)

    Chang, Joonho; Freivalds, Andris; Sharkey, Neil A; Kong, Yong-Ku; Mike Kim, H; Sung, Kiseok; Kim, Dae-Min; Jung, Kihyo

    2017-11-01

    A cadaver study was conducted to investigate the effects of triggering conditions (trigger grip span, contact location, and internal tendon force) on index finger triggering force and the force efficiency of involved tendons. Eight right human cadaveric hands were employed, and a motion simulator was built to secure and control the specimens. Index finger triggering forces were investigated as a function of different internal tendon forces (flexor digitorum profundus + flexor digitorum superficialis = 40, 70, and 100 N), trigger grip spans (40, 50, and 60 mm), and contact locations between the index finger and a trigger. Triggering forces significantly increased when internal tendon forces increased from 40 to 100 N. Also, trigger grip spans and contact locations had significant effects on triggering forces; maximum triggering forces were found at a 50 mm span and the most proximal contact location. The results revealed that only 10-30% of internal tendon forces were converted to their external triggering forces. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. (Environmental investigation of ground water contamination at Wright- Patterson Air Force Base, Ohio)

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-01

    This Health and Safety Plan (HSP) was developed for the Environmental Investigation of Ground-water Contamination Investigation at Wright-Patterson Air Force Base near Dayton, Ohio, based on the projected scope of work for the Phase 1, Task 4 Field Investigation. The HSP describes hazards that may be encountered during the investigation, assesses the hazards, and indicates what type of personal protective equipment is to be used for each task performed. The HSP also addresses the medical monitoring program, decontamination procedures, air monitoring, training, site control, accident prevention, and emergency response.

  2. EXPERIMENTAL INVESTIGATION OF THE IMPACT OF FLIGHT SPEED ON DRAG FORCE IN THE AUTOGYRO MODEL

    OpenAIRE

    Zbigniew Czyż; Paweł Magryta; Marcin Szlachetka

    2015-01-01

    The paper presents the experimental investigation of the impact of velocity on drag force in the autogyro model. One of the methods which simulate motion of the flying object consists of using a wind tunnel. In this case, test object is stationary and the motion of air is forced by e.g. a special fan. The costs related with renting and the wind tunnel service are still very high. In this paper, the motion of the autogyro with respect to the air, was produced by fixing this model with scale to...

  3. Investigation of the nucleon-nucleon tensor force in three-nucleon system

    Energy Technology Data Exchange (ETDEWEB)

    Clajus, M.; Egun, P.M.; Gruebler, W.; Hautle, P. (Eidgenoessische Technische Hochschule, Zurich (Switzerland). Inst. fuer Mittelenergiephysik); Slaus, I. (Institut Rudjer Boskovic, Zagreb (Yugoslavia)); Vuaridel, B. (Michigan Univ., Ann Arbor (USA) Brookhaven National Lab., Upton, NY (USA)); Sperisen, F. (Indiana Univ., Bloomington (USA). Cyclotron Facility); Kretschmer, W.; Rauscher, A.; Schuster, W.; Weidmann, R.; Haller, M. (Erlangen-Nuernberg Univ., Erlangen (Germany, F.R.)); Bruno, M.; Cannata, F.; D' Agostino, M. (Istituto Nazionale di Fisica Nucleare, Bologna (Italy)); Witala, H.; Cornelius, T.; Gloeckle, W. (Bochum Univ. (Germany, F.R.)); Schmelzbach, P.A. (Paul Scherrer Inst., Villigen (Switzerland))

    1990-08-16

    Proton-deuteron elastic scattering has been investigated at E{sub p}=22.7 MeV by comparison of rigorous Faddeev calculations with experimental results. The observable most sensitive to the tensor force is the nucleon-nucleon polarization transfer coefficient K{sub y}sup(y'). The new angular distribution of K{sub y}sup(y') clearly favours the tensor force of the Bonn A potential, which is weaker than the one of the Paris potential. (orig.).

  4. Investigation of Tension Forces in A Stay Cable System of A Road Bridge Using Vibration Methods

    Directory of Open Access Journals (Sweden)

    Hawryszków Paweł

    2015-01-01

    Full Text Available In the article author presents method of investigation of tension forces in stay cable systems using dynamical methods. Research was carried out during stay cable system installation on WN-24 viaduct near Poznań, that is way it was possible to compare tension forces indicated directly by devices using for tensioning of cable-stayed bridges with results achieved indirectly by means of dynamical methods. Discussion of results was presented. Advantages of dynamical methods and possible fields of application was described. This method, which has been rarely used before, may occur interesting alternative in diagnostics of bridges in comparison to traditional methods.

  5. Investigating the effect of clamping force on the fatigue life of bolted plates using volumetric approach

    International Nuclear Information System (INIS)

    Esmaeili, F.; Chakherlou, T. N.; Zehsaz, M.; Hasanifard, S.

    2013-01-01

    In this paper, the effects of bolt clamping force on the fatigue life for bolted plates made from Al7075-T6 have been studied on the values of notch strength reduction factor obtained by volumetric approach. To attain stress distribution around the notch (hole) which is required for volumetric approach, nonlinear finite element simulations were carried out. To estimate the fatigue life, the available smooth S-N curve of Al7075-T6 and the notch strength reduction factor obtained from volumetric method were used. The estimated fatigue life was compared with the available experimental test results. The investigation shows that there is a good agreement between the life predicted by the volumetric approach and the experimental results for various specimens with different amount of clamping forces. Volumetric approach and experimental results showed that the fatigue life of bolted plates improves because of the compressive stresses created around the plate hole due to clamping force.

  6. An investigation into electromagnetic force models: differences in global and local effects demonstrated by selected problems

    Science.gov (United States)

    Reich, Felix A.; Rickert, Wilhelm; Müller, Wolfgang H.

    2018-03-01

    This study investigates the implications of various electromagnetic force models in macroscopic situations. There is an ongoing academic discussion which model is "correct," i.e., generally applicable. Often, gedankenexperiments with light waves or photons are used in order to motivate certain models. In this work, three problems with bodies at the macroscopic scale are used for computing theoretical model-dependent predictions. Two aspects are considered, total forces between bodies and local deformations. By comparing with experimental data, insight is gained regarding the applicability of the models. First, the total force between two cylindrical magnets is computed. Then a spherical magnetostriction problem is considered to show different deformation predictions. As a third example focusing on local deformations, a droplet of silicone oil in castor oil is considered, placed in a homogeneous electric field. By using experimental data, some conclusions are drawn and further work is motivated.

  7. Investigating the relationship between pressure force and acoustic waveform in footstep sounds

    DEFF Research Database (Denmark)

    Grani, Francesco; Serafin, Stefania; Götzen, Amalia De

    2013-01-01

    In this paper we present an inquiry into of the relationships between audio waveforms and ground reaction force in recorded footstep sounds. In an anechoic room, we recorded several footstep sounds produced while walking on creaking wood and gravel. The recordings were performed by using a pair o...... of sandals embedded with six pressure sensors each. Investigations of the relationships between recorded force and footstep sounds is presented, together with several possible applications of the system.......In this paper we present an inquiry into of the relationships between audio waveforms and ground reaction force in recorded footstep sounds. In an anechoic room, we recorded several footstep sounds produced while walking on creaking wood and gravel. The recordings were performed by using a pair...

  8. Manipulating Light and Matter with Photonic Structures: Numerical Investigations on Photonic Crystals and Optical Forces

    Science.gov (United States)

    Zhang, Peng

    The highly developed nano-fabrication techniques allow light to be modulated with photonic structures in a more intensive way. These photonic structures involve photonic crystals, metals supporting surface plasmon polaritons, metamaterials, etc. In this thesis work, three different ways for light manipulation are numerically investigated. First, the light propagation is modulated using a photonic crystal with Dirac cones. It is demonstrated that the zero-index behavior of this photonic crystal which happens for normal incident waves, is lost at oblique incidence. A new method combining complex-k band calculations and absorbing boundary conditions for Bloch modes is developed to analyze the Bloch mode interaction in details. Second, the mechanic states of graphene are modulated through the optical gradient force. This force is induced by the coupled surface plasmons on the double graphene sheets and is greatly enhanced in comparison to the regular waveguides. By applying different strengths of forces in accordance to the input power, the mechanic state transition is made possible, accompanied by an abrupt change in the transmission and reflection spectra. Third, the helicity/chirality of light is studied to modulate the lateral force on a small particle. A left-hand material slab which supports coherent TE ad TM plasmons simultaneously is introduced. By mixing the TE and TM surface plasmons with different relative phases, the lateral force on a chiral particle can be changed, which will be beneficial for chiral particle sorting.

  9. EXPERIMENTAL INVESTIGATION OF THE IMPACT OF FLIGHT SPEED ON DRAG FORCE IN THE AUTOGYRO MODEL

    Directory of Open Access Journals (Sweden)

    Zbigniew Czyż

    2015-05-01

    Full Text Available The paper presents the experimental investigation of the impact of velocity on drag force in the autogyro model. One of the methods which simulate motion of the flying object consists of using a wind tunnel. In this case, test object is stationary and the motion of air is forced by e.g. a special fan. The costs related with renting and the wind tunnel service are still very high. In this paper, the motion of the autogyro with respect to the air, was produced by fixing this model with scale to measure the drag force on the passenger car roof. The position of the object relative to the vehicle was checked on the basis of numerical analysis of the airflow around this vehicle. Based on the investigations, the field of velocity and pressure, and air flow formed around the contour of the vehicle which have been chosen, were determined. In addition, the drag force characteristic was determined as a function of velocity and it was compared with the values from the numerical analysis. This research is a form of verifying opportunities for this type of research on vehicles. The conclusions derived from the analysis of the results will be used in the future to carry out further research.

  10. Investigation of integrin expression on the surface of osteoblast-like cells by atomic force microscopy

    International Nuclear Information System (INIS)

    Caneva Soumetz, Federico; Saenz, Jose F.; Pastorino, Laura; Ruggiero, Carmelina; Nosi, Daniele; Raiteri, Roberto

    2010-01-01

    The transforming growth factor β1 (TGF-β1) is a human cytokine which has been demonstrated to modulate cell surface integrin repertoire. In this work integrin expression in response to TGF-β1 stimulation has been investigated on the surface of human osteoblast-like cells. We used atomic force microscopy (AFM) and confocal laser scanning microscopy to assess integrin expression and to evaluate their distribution over the dorsal side of the plasma membrane. AFM probes have been covalently functionalised with monoclonal antibodies specific to the β1 integrin subunit. Force curves have been collected in order to obtain maps of the interaction between the immobilized antibody and the respective cell membrane receptors. Adhesion peaks have been automatically detected by means of an ad hoc developed data analysis software. The specificity of the detected interactions has been assessed by adding free antibody in the solution and monitoring the dramatic decrease in the recorded interactions. In addition, the effect of TGF-β1 treatment on both the fluorescence signal and the adhesion events has been tested. The level of expression of the β1 integrin subunit was enhanced by TGF-β1. As a further analysis, the adhesion force of the single living cells to the substrate was measured by laterally pushing the cell with the AFM tip and measuring the force necessary to displace it. The treatment with TGF-β1 resulted in a decrease of the cell/substrate adhesion force. Results obtained by AFM have been validated by confocal laser scanning microscopy thus demonstrating the high potential of the AFM technique for the investigation of cell surface receptors distribution and trafficking at the nanoscale.

  11. Bimanual elbow robotic orthoses: preliminary investigations on an impairment force feedback rehabilitation method

    Directory of Open Access Journals (Sweden)

    Gil eHerrnstadt

    2015-03-01

    Full Text Available Modern rehabilitation practices have begun integrating robots, recognizing their significant role in recovery. New and alternative stroke rehabilitation treatments are essential to enhance efficacy and mitigate associated health costs. Today’s robotic interventions can play a significant role in advancing rehabilitation. In addition, robots have an inherent ability to perform tasks accurately and reliably and are typically well suited to measure and quantify performance.Most rehabilitation strategies predominantly target activation of the paretic arm. However, bimanual upper limb rehabilitation research suggests potential in enhancing functional recovery. Moreover studies suggest limb coordination and synchronization can improve treatment efficacy.In this preliminary study, we aimed to investigate and validate our user-driven bimanual system in a reduced intensity rehab practice. A Bimanual Wearable Robotic Device (BWRD with a Master-Slave configuration for the elbow joint was developed to carry out the investigation. The BWRD incorporates position and force sensors for which respective control loops are implemented, and offers varying modes of operation ranging from passive to active training. The proposed system enables the perception of the movements, as well as the forces applied by the hemiparetic arm, with the non-hemiparetic arm. Eight participants with chronic unilateral stroke were recruited to participate in a total of three one-hour sessions per participant, delivered in a week. Participants underwent pre and post training functional assessments along with proprioceptive measures. The post assessment was performed at the end of the last training session.The protocol was designed to engage the user in an assortment of static and dynamic arm matching and opposing tasks. The training incorporates force feedback movements, force feedback positioning, and force matching tasks with same and opposite direction movements. We are able to

  12. Investigation of integrin expression on the surface of osteoblast-like cells by atomic force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Caneva Soumetz, Federico [Department of Communication, Computer and System Sciences, University of Genova, Via Opera Pia, 13-16145 Genova (Italy); Saenz, Jose F. [Biophysical and Electronic Engineering Department, University of Genova, Via All' Opera Pia 11a, 16145 Genova (Italy); Pastorino, Laura; Ruggiero, Carmelina [Department of Communication, Computer and System Sciences, University of Genova, Via Opera Pia, 13-16145 Genova (Italy); Nosi, Daniele [Department of Anatomy, Histology and Forensic Medicine, Bio-photonic Laboratory, University of Florence, viale Morgagni, 85 Firenze, CAP 50134 Florence (Italy); Raiteri, Roberto, E-mail: rr@unige.it [Biophysical and Electronic Engineering Department, University of Genova, Via All' Opera Pia 11a, 16145 Genova (Italy)

    2010-03-15

    The transforming growth factor {beta}1 (TGF-{beta}1) is a human cytokine which has been demonstrated to modulate cell surface integrin repertoire. In this work integrin expression in response to TGF-{beta}1 stimulation has been investigated on the surface of human osteoblast-like cells. We used atomic force microscopy (AFM) and confocal laser scanning microscopy to assess integrin expression and to evaluate their distribution over the dorsal side of the plasma membrane. AFM probes have been covalently functionalised with monoclonal antibodies specific to the {beta}1 integrin subunit. Force curves have been collected in order to obtain maps of the interaction between the immobilized antibody and the respective cell membrane receptors. Adhesion peaks have been automatically detected by means of an ad hoc developed data analysis software. The specificity of the detected interactions has been assessed by adding free antibody in the solution and monitoring the dramatic decrease in the recorded interactions. In addition, the effect of TGF-{beta}1 treatment on both the fluorescence signal and the adhesion events has been tested. The level of expression of the {beta}1 integrin subunit was enhanced by TGF-{beta}1. As a further analysis, the adhesion force of the single living cells to the substrate was measured by laterally pushing the cell with the AFM tip and measuring the force necessary to displace it. The treatment with TGF-{beta}1 resulted in a decrease of the cell/substrate adhesion force. Results obtained by AFM have been validated by confocal laser scanning microscopy thus demonstrating the high potential of the AFM technique for the investigation of cell surface receptors distribution and trafficking at the nanoscale.

  13. Force Concept Inventory-based multiple-choice test for investigating students’ representational consistency

    Directory of Open Access Journals (Sweden)

    Pasi Nieminen

    2010-08-01

    Full Text Available This study investigates students’ ability to interpret multiple representations consistently (i.e., representational consistency in the context of the force concept. For this purpose we developed the Representational Variant of the Force Concept Inventory (R-FCI, which makes use of nine items from the 1995 version of the Force Concept Inventory (FCI. These original FCI items were redesigned using various representations (such as motion map, vectorial and graphical, yielding 27 multiple-choice items concerning four central concepts underpinning the force concept: Newton’s first, second, and third laws, and gravitation. We provide some evidence for the validity and reliability of the R-FCI; this analysis is limited to the student population of one Finnish high school. The students took the R-FCI at the beginning and at the end of their first high school physics course. We found that students’ (n=168 representational consistency (whether scientifically correct or not varied considerably depending on the concept. On average, representational consistency and scientifically correct understanding increased during the instruction, although in the post-test only a few students performed consistently both in terms of representations and scientifically correct understanding. We also compared students’ (n=87 results of the R-FCI and the FCI, and found that they correlated quite well.

  14. Theoretical investigation of the distance dependence of capillary and van der Waals forces in scanning force microscopy

    International Nuclear Information System (INIS)

    Stifter, Thomas; Marti, Othmar; Bhushan, Bharat

    2000-01-01

    The capillary and van der Waals forces between a tip and a plane in a scanning force microscope (SFM) are calculated. The forces are calculated for a fixed distance of tip and sample, as well as during retracting of the tip from the sample surface. The exact geometric shape of the meniscus is considered, with the boundary condition of fixed liquid volume during retraction. The starting volume is given by the operating and environmental conditions (surface tension, humidity, and tip geometry) at the point of lowest distance between tip and surface. The influence of the different parameters, namely, humidity, tip geometry, tip-sample starting distance, surface tension, and contact angles are studied. For each force curve also the geometric shape of the meniscus is calculated. The capillary forces are compared with van der Waals forces to understand their relative importance in various operating conditions. In addition to application in SFM, this analysis is useful in the design of surface roughness in microdevices for low adhesion in operating environments

  15. Investigation of the hydrodynamic model test of forced rolling for a barge using PIV

    Directory of Open Access Journals (Sweden)

    WANG Xiaoqiang

    2017-03-01

    Full Text Available In order to study the physical details of viscous flow in ship roll motions and improve the accuracy of ship roll damping numerical simulation, the application of the Particle Image Velocimetry (PIV technique is investigated in model tests of forced ship rolling in calm water. The hydrodynamic force and flow field at the bilge region are simultaneously measured for barges at different amplitudes and frequencies in which the self-made forced rolling facility was used. In the model test, the viscous flow variation with the time around the bilge region was studied during ship rolling motion. The changes in ship roll damping coefficients with the rolling amplitude and period were also investigated. A comparison of the model test results with the Computational Fluid Dynamics(CFDresults shows that the numerical ship roll damping coefficients agree well with the model test results, while the differences in the local flow details exist between the CFD results and model test results. Further research into the model test technique and CFD application is required.

  16. Experimental investigation of Surface Roughness and Cutting force in CNC Turning - A Review

    Directory of Open Access Journals (Sweden)

    Dhiraj Patel

    2014-08-01

    Full Text Available The main purpose of this review paper is to check whether quality lies within desired tolerance level which can be accepted by the customers. So, experimental investigation surface roughness and cutting force using various CNC machining parameters including spindle speed (N, feed rate (f, and depth of cut (d,flow rate (Q and insert nose radius (r. As such, a solemn attempt is made in this paper to investigate the response parameters, viz., Cutting force and Surface Roughness (Ra a by experimentation on EN 19 turning process. The Design of experiments is carried-out considering Taguchi Technique with four input parameters, namely, spindle speed, feed rate, and depth of cut, flow rate and insert nose radius .The experiments are conducted considering the above materials for L16 and then the impact of each parameter is estimated by ANOAVA. Then the regression analysis is carried-out to find the trend of the response of each material. This experimental study aims at taguchi method has been applied for finding the effect on surface roughness and cutting force by various process parameters. And after that we can easily find out that which parameter will be more affect.

  17. Investigation into local cell mechanics by atomic force microscopy mapping and optical tweezer vertical indentation.

    Science.gov (United States)

    Coceano, G; Yousafzai, M S; Ma, W; Ndoye, F; Venturelli, L; Hussain, I; Bonin, S; Niemela, J; Scoles, G; Cojoc, D; Ferrari, E

    2016-02-12

    Investigating the mechanical properties of cells could reveal a potential source of label-free markers of cancer progression, based on measurable viscoelastic parameters. The Young's modulus has proved to be the most thoroughly studied so far, however, even for the same cell type, the elastic modulus reported in different studies spans a wide range of values, mainly due to the application of different experimental conditions. This complicates the reliable use of elasticity for the mechanical phenotyping of cells. Here we combine two complementary techniques, atomic force microscopy (AFM) and optical tweezer microscopy (OTM), providing a comprehensive mechanical comparison of three human breast cell lines: normal myoepithelial (HBL-100), luminal breast cancer (MCF-7) and basal breast cancer (MDA-MB-231) cells. The elastic modulus was measured locally by AFM and OTM on single cells, using similar indentation approaches but different measurement parameters. Peak force tapping AFM was employed at nanonewton forces and high loading rates to draw a viscoelastic map of each cell and the results indicated that the region on top of the nucleus provided the most meaningful results. OTM was employed at those locations at piconewton forces and low loading rates, to measure the elastic modulus in a real elastic regime and rule out the contribution of viscous forces typical of AFM. When measured by either AFM or OTM, the cell lines' elasticity trend was similar for the aggressive MDA-MB-231 cells, which were found to be significantly softer than the other two cell types in both measurements. However, when comparing HBL-100 and MCF-7 cells, we found significant differences only when using OTM.

  18. Investigating the binding behaviour of two avidin-based testosterone binders using molecular recognition force spectroscopy.

    Science.gov (United States)

    Rangl, Martina; Leitner, Michael; Riihimäki, Tiina; Lehtonen, Soili; Hytönen, Vesa P; Gruber, Hermann J; Kulomaa, Markku; Hinterdorfer, Peter; Ebner, Andreas

    2014-02-01

    Molecular recognition force spectroscopy, a biosensing atomic force microscopy technique allows to characterise the dissociation of ligand-receptor complexes at the molecular level. Here, we used molecular recognition force spectroscopy to study the binding capability of recently developed testosterone binders. The two avidin-based proteins called sbAvd-1 and sbAvd-2 are expected to bind both testosterone and biotin but differ in their binding behaviour towards these ligands. To explore the ligand binding and dissociation energy landscape of these proteins, we tethered biotin or testosterone to the atomic force microscopy probe while the testosterone-binding protein was immobilized on the surface. Repeated formation and rupture of the ligand-receptor complex at different pulling velocities allowed determination of the loading rate dependence of the complex-rupturing force. In this way, we obtained the molecular dissociation rate (k(off)) and energy landscape distances (x(β)) of the four possible complexes: sbAvd-1-biotin, sbAvd-1-testosterone, sbAvd-2-biotin and sbAvd-2-testosterone. It was found that the kinetic off-rates for both proteins and both ligands are similar. In contrast, the x(β) values, as well as the probability of complex formations, varied considerably. In addition, competitive binding experiments with biotin and testosterone in solution differ significantly for the two testosterone-binding proteins, implying a decreased cross-reactivity of sbAvd-2. Unravelling the binding behaviour of the investigated testosterone-binding proteins is expected to improve their usability for possible sensing applications. Copyright © 2014 John Wiley & Sons, Ltd.

  19. [Environmental investigation of ground water contamination at Wright-Patterson Air Force Base, Ohio]. Volume 5, Field Investigation report

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    An environmental investigation of ground water conditions has been undertaken at Wright-Patterson Air Force Base (WPAFB), Ohio to obtain data to assist in the evaluation of a potential removal action to prevent, to the extent practicable, migration of the contaminated ground water across Base boundaries. Field investigations were limited to the central section of the southwestern boundary of Area C and the Springfield Pike boundary of Area B. Further, the study was limited to a maximum depth of 150 feet below grade. Three primary activities of the field investigation were: (1) installation of 22 monitoring wells, (2) collection and analysis of ground water from 71 locations, (3) measurement of ground water elevations at 69 locations. Volatile organic compounds including trichloroethylene, perchloroethylene, and/or vinyl chloride were detected in concentrations exceeding Maximum Contaminant Levels (MCL) at three locations within the Area C investigation area. Ground water at the Springfield Pike boundary of Area B occurs in two primary units, separated by a thicker-than-expected clay layers. One well within Area B was determined to exceed the MCL for trichloroethylene.

  20. Atomic force microscopic investigation of commercial pressure sensitive adhesives for forensic analysis.

    Science.gov (United States)

    Canetta, Elisabetta; Adya, Ashok K

    2011-07-15

    Pressure sensitive adhesive (PSA), such as those used in packaging and adhesive tapes, are very often encountered in forensic investigations. In criminal activities, packaging tapes may be used for sealing packets containing drugs, explosive devices, or questioned documents, while adhesive and electrical tapes are used occasionally in kidnapping cases. In this work, the potential of using atomic force microscopy (AFM) in both imaging and force mapping (FM) modes to derive additional analytical information from PSAs is demonstrated. AFM has been used to illustrate differences in the ultrastructural and nanomechanical properties of three visually distinguishable commercial PSAs to first test the feasibility of using this technique. Subsequently, AFM was used to detect nanoscopic differences between three visually indistinguishable PSAs. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  1. Investigation of specific interactions between T7 promoter and T7 RNA polymerase by force spectroscopy using atomic force microscope.

    Science.gov (United States)

    Zhang, Xiaojuan; Yao, Zhixuan; Duan, Yanting; Zhang, Xiaomei; Shi, Jinsong; Xu, Zhenghong

    2018-01-11

    The specific recognition and binding of promoter and RNA polymerase is the first step of transcription initiation in bacteria and largely determines transcription activity. Therefore, direct analysis of the interaction between promoter and RNA polymerase in vitro may be a new strategy for promoter characterization, to avoid interference due to the cell's biophysical condition and other regulatory elements. In the present study, the specific interaction between T7 promoter and T7 RNA polymerase was studied as a model system using force spectroscopy based on atomic force microscope (AFM). The specific interaction between T7 promoter and T7 RNA polymerase was verified by control experiments, and the rupture force in this system was measured as 307.2 ± 6.7 pN. The binding between T7 promoter mutants with various promoter activities and T7 RNA polymerase was analyzed. Interaction information including rupture force, rupture distance and binding percentage were obtained in vitro , and reporter gene expression regulated by these promoters was also measured according to a traditional promoter activity characterization method in vivo Using correlation analysis, it was found that the promoter strength characterized by reporter gene expression was closely correlated with rupture force and the binding percentage by force spectroscopy. These results indicated that the analysis of the interaction between promoter and RNA polymerase using AFM-based force spectroscopy was an effective and valid approach for the quantitative characterization of promoters. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

  2. Experimental Investigation of Unsteady Aerodynamic Forces on Airfoil in Harmonic Translatory Motion

    DEFF Research Database (Denmark)

    Gaunaa, Mac; Sørensen, Jens Nørkær

    2003-01-01

    The present paper describes the main results from an experimental investigation of the unsteady aerodynamic forces on a NACA 0015 airfoil subject to 1-degree-of-freedom (DOF) harmonic translatory motion. The focus of the experimental investigations was to determine the factors that influence...... maximum lift for both stationary and moving airfoil configurations. The mean as well as the dynamic characteristics of the different stall levels were found to differ from each other. An investigation of the negative aerodynamically damped cases showed that the damping decrease as the reduced frequency...... is decreased. Comparison between the experimental data, 2D Navier-Stokes computations and two commonly used dynamic stall models reveal that all models failed to reproduce the dynamic characteristics of the flow for incidences above maximum lift, however the Navier-Stokes computations generally captured...

  3. Forces, energetics, and dynamics of conjugated-carbon ring tethers adhered to CNTs: a computational investigation.

    Science.gov (United States)

    Filla, Nicholas; Ramasamy, Ramaraja; Wang, Xianqiao

    2018-04-25

    The strength and nature of the interactions between carbon nanotubes (CNTs) and molecular tethers plays a vital role in technology such as CNT-enzyme sensors. Tethers that attach noncovalently to CNTs are ideal for retaining the electrical properties of the CNTs since they do not degrade the CNT surface and effect its electrical conductivity. However, leaching due to weak CNT-tether attachment is very common when using noncovalent tethers, and this has limited their use in commercial products including biosensors. Thus, understanding the fundamental mechanics governing the strength of CNT-tether adhesion is crucial for the design of highly sensitive, viable sensors. Here, we computationally investigate the adhesion strength of CNT-tether complexes with 8 different tethering molecules designed to adhere noncovalently to the CNT surface. We study the effects of CNT diameter, CNT chirality, and the size/geometry of the tethering molecule on the adhesion energy and force. Our results show an asymptotic relationship between adhesion strength and CNT diameter. Calculations show that noncovalent tethers tested here can reach adhesion forces and energies that are up to 21% and 54% of the strength of the carbon-carbon single bond force and bond energy respectively. We anticipate our results will help guide CNT-enzyme sensor design to produce sensors with high sensitivity and minimal leaching.

  4. Operable Unit 1 remedial investigation report, Eielson Air Force Base, Alaska

    International Nuclear Information System (INIS)

    Gilmore, T.J.; Fruland, R.M.; Liikala, T.L.

    1994-06-01

    This remedial investigation report for operable Unit 1 (OU-1) at Eielson Air Force Base presents data, calculations, and conclusions as to the nature and extent of surface and subsurface contamination at the eight source areas that make up OU-1. The information is based on the 1993 field investigation result and previous investigations. This report is the first in a set of three for OU-1. The other reports are the baseline risk assessment and feasibility study. The information in these reports will lead to a Record of Decision that will guide and conclude the environmental restoration effort for OU-1 at Eielson Air Force Base. The primary contaminants of concern include fuels and fuel-related contaminants (diesel; benzene, toluene, ethylbenzene, and xylene; total petroleum hydrocarbon; polycyclic aromatic hydrocarbons), maintenance-related solvents and cleaners (volatile chlorinated hydrocarbons such as trichloroothylene), polychlorinated biphenyls, and dichlorodiphenyltrichloroethane (DDT). The origins of contaminants of concern include leaks from storage tanks, drums and piping, and spills. Ongoing operations and past sitewide practices also contribute to contaminants of concern at OU-1 source areas. These include spraying mixed oil and solvent wastes on unpaved roads and aerial spraying of DDT

  5. Investigating the Role of Ferromagnetic Materials on the Casimir Force & Investigation of the Van Der Waals/Casimir Force with Graphene

    Energy Technology Data Exchange (ETDEWEB)

    Mohideen, Umar [Univ. of California, Riverside, CA (United States)

    2015-04-14

    Duration of award was from 4/15/10-4/14/15. In this grant period our contributions to the field of VdW/Casimir forces are 24 refereed publications in journals such as Physical Review Letters (4) [1-4], Physical Review B (10) [5-14], Physical Review D (2) [15,16], Applied Physics Letters (1) [17], Review of Scientific Instruments (1) [18] and the International Journal of Modern Physics A (5) [19-23] and B(1) (invited review article [24]). We presented 2 plenary conference talks, 3 lectures at the Pan American School on Frontiers in Casimir Physics, 2 conferences, 1 colloquium and 11 APS talks. If publications are restricted to only those with direct connection to the aims proposed in the prior grant period, then it will be a total of 12: Physical Review Letters (3) [2-4], Physical Review B (6) [6-8,12,13,25], Review of Scientific Instruments (1) [18], International Journal of Modern Physics A (1) [19] and B(1) [169]. A brief aggregated description of the directly connected accomplishments is below. The following topics are detailed: dispersion force measurements with graphene, dispersion force from ferromagnetic metals, conclusion on role of electrostatic patches, UV radiation induced modification of the Casimir force, low temperature measurement of the Casimir force, and Casimir force from thin fluctuating membranes.

  6. An investigation of transition boiling mechanisms of subcooled water under forced convective conditions

    Energy Technology Data Exchange (ETDEWEB)

    Kwang-Won, Lee; Sang-Yong, Lee

    1995-09-01

    A mechanistic model for forced convective transition boiling has been developed to investigate transition boiling mechanisms and to predict transition boiling heat flux realistically. This model is based on a postulated multi-stage boiling process occurring during the passage time of the elongated vapor blanket specified at a critical heat flux (CHF) condition. Between the departure from nucleate boiling (DNB) and the departure from film boiling (DFB) points, the boiling heat transfer is established through three boiling stages, namely, the macrolayer evaporation and dryout governed by nucleate boiling in a thin liquid film and the unstable film boiling characterized by the frequent touches of the interface and the heated wall. The total heat transfer rates after the DNB is weighted by the time fractions of each stage, which are defined as the ratio of each stage duration to the vapor blanket passage time. The model predictions are compared with some available experimental transition boiling data. The parametric effects of pressure, mass flux, inlet subcooling on the transition boiling heat transfer are also investigated. From these comparisons, it can be seen that this model can identify the crucial mechanisms of forced convective transition boiling, and that the transition boiling heat fluxes including the maximum heat flux and the minimum film boiling heat flux are well predicted at low qualities/high pressures near 10 bar. In future, this model will be improved in the unstable film boiling stage and generalized for high quality and low pressure situations.

  7. Investigation of the Effect of Neck Muscle Active Force on Whiplash Injury of the Cervical Spine

    Directory of Open Access Journals (Sweden)

    Yu Yan

    2018-01-01

    Full Text Available The objective of the present study is to investigate the influence of neck muscle activation on whiplash neck injury of the occupants of a passenger vehicle under different severities of frontal and rear-end impact collisions. The finite element (FE model has been used as a versatile tool to simulate and understand the whiplash injury mechanism for occupant injury prevention. However, whiplash injuries and injury mechanisms have rarely been investigated in connection with neck active muscle forces, which restricts the complete reappearance and understanding of the injury mechanism. In this manuscript, a mixed FE human model in a sitting posture with an active head-neck was developed. The response of the cervical spine under frontal and rear-end collision conditions was then studied using the FE model with and without neck muscle activation. The effect of the neck muscle activation on the whiplash injury was studied based on the results of the FE simulations. The results indicated that the neck active force influenced the head-neck dynamic response and whiplash injury during a collision, especially in a low-speed collision.

  8. INVESTIGATION OF POLYMER SURFACES USING SCANNING FORCE MICROSCOPY (SFM) - A NEW DIRECT LOOK ON OLD POLYMER PROBLEMS

    NARCIS (Netherlands)

    GRIM, PCM; BROUWER, HJ; SEYGER, RM; OOSTERGETEL, GT; BERGSMASCHUTTER, WG; ARNBERG, AC; GUTHNER, P; DRANSFELD, K; HADZIIOANNOU, G

    In this contribution, the general concepts of force microscopy will be presented together with its application to polymer surfaces (Ref.1). Several examples will be presented to illustrate that force microscopy is a powerful and promising tool for investigation of (polymer) surfaces, such as the

  9. Investigation of a double oscillating-fan cooling device using electromagnetic force

    International Nuclear Information System (INIS)

    Su, Hsien-Chin; Xu, Han Yang

    2016-01-01

    Highlights: • The characteristics of a double oscillating-fan cooling device using electromagnetic force was investigated. • The driving current can be either DC PWM or AC within 3–12 V. • The comparison between a double blower pair, the model and a synjet were examined. • A 50 mm ∗ 50 mm ∗ 15 mm model can provide the flow rate of 154.89 l/min while consuming 0.65 W. • The flow rate, sound pressure, power consumption and two thermal tests have been done. - Abstract: This study proposes a double oscillating-fan cooling device using electromagnetic force. The device consists of two oscillating-fans. It requires only one electromagnet and two fan sheets with one magnet on each of them. The electromagnet and fan sheets are situated on a base and arranged accordingly. The electromagnetic force generated by the electromagnet can actuate the fan sheets. The main advantage of the device is its simple structure because there is no bearing and motor in the device. The driving current can be either DC PWM (Pulse width modulation) or AC (Alternating current) within 3–12 V so it is compatible with most electronic devices. The dimensions of the proposed model are 50 mm ∗ 50 mm ∗ 15 mm during operation. Concerning flow rate, sound pressure, power consumption and resonant frequency tests, a comparison between the proposed model and different type of cooling devices has been completed. The result shows that the model can provide cooling ability similar to a rotary fan while consuming 40% of the power of the rotary fan. It shows not only a good cooling ability but also a great potential for structural reliability and design flexibility.

  10. (Environmental investigation of ground water contamination at Wright-Patterson Air Force Base, Ohio)

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    An environmental investigation of ground water conditions has been undertaken at Wright-Patterson Air Force Base (WPAFB), Ohio to obtain data to assist in the evaluation of a potential removal action to prevent, to the extent practicable, migration of the contaminated ground water across Base boundaries. Field investigations were limited to the central section of the southwestern boundary of Area C and the Springfield Pike boundary of Area B. Further, the study was limited to a maximum depth of 150 feet below grade. Three primary activities of the field investigation were: (1) installation of 22 monitoring wells, (2) collection and analysis of ground water from 71 locations, (3) measurement of ground water elevations at 69 locations. Volatile organic compounds including trichloroethylene, perchloroethylene, and/or vinyl chloride were detected in concentrations exceeding Maximum Contaminant Levels (MCL) at three locations within the Area C investigation area. Ground water at the Springfield Pike boundary of Area B occurs in two primary units, separated by a thicker-than-expected clay layers. One well within Area B was determined to exceed the MCL for trichloroethylene.

  11. Morphology of compressed dipalmitoyl phosphatidylcholine monolayers investigated by atomic force microscopy

    International Nuclear Information System (INIS)

    Yang, Y.-P.; Tsay, R.-Y.

    2007-01-01

    The effectiveness of a substitute of natural lung surfactants on replacement therapy strongly depends on the stability of the monolayer of those substitute molecules. An atomic force microscope is utilized to investigate the microstructure of the films of the major components of natural lung surfactants, dipalmitoyl phosphatidylcholine-DPPC, which are transferred to mica substrates by the Langmuir-Blodgett film technique. A concave deformation structure was first observed for DPPC in solid phase. The depth of the concave domain was about 6 nm and was remarkably uniform. For a collapsed DPPC monolayer, the surface film consists of a granular convex multilayer structure and a disc-like concave structure. Dynamic cyclic compression-expansion experiments indicate that the formation of the concave domain is a reversible process while the process for convex multilayer formation is irreversible. This gives direct evidence that convex grain is the collapsed structure of DPPC monolayer and the concave shallow disc corresponds to the elastic deformation of a DPPC solid film. Results of atomic force microscopy indicate that the nucleation and growth model instead of the fracture model can better describe the collapse behavior of a DPPC monolayer

  12. How to orient the functional GroEL-SR1 mutant for atomic force microscopy investigations

    International Nuclear Information System (INIS)

    Schiener, Jens; Witt, Susanne; Hayer-Hartl, Manajit; Guckenberger, Reinhard

    2005-01-01

    We present high-resolution atomic force microscopy (AFM) imaging of the single-ring mutant of the chaperonin GroEL (SR-EL) from Escherichia coli in buffer solution. The native GroEL is generally unsuitable for AFM scanning as it is easily being bisected by forces exerted by the AFM tip. The single-ring mutant of GroEL with its simplified composition, but unaltered capability of binding substrates and the co-chaperone GroES, is a more suited system for AFM studies. We worked out a scheme to systematically investigate both the apical and the equatorial faces of SR-EL, as it binds in a preferred orientation to hydrophilic mica and hydrophobic highly ordered pyrolytic graphite. High-resolution topographical imaging and the interaction of the co-chaperone GroES were used to assign the orientations of SR-EL in comparison with the physically bisected GroEL. The usage of SR-EL facilitates single molecule studies on the folding cycle of the GroE system using AFM

  13. A numerical investigation of laminar forced convection in a solar collector with non-circular duct

    Directory of Open Access Journals (Sweden)

    Teleszewski Tomasz Janusz

    2017-01-01

    Full Text Available This paper presents a two-dimensional numerical study to investigate laminar flow in a flat plate solar collector with non-circular duct (regular polygonal, elliptical, and Cassini oval shape featuring forced convection with constant axial wall heat flux and constant peripheral wall temperature (H1 condition. Applying the velocity profile obtained for the duct laminar flow, the energy equation was solved exactly for the constant wall heat flux using the Boundary Element Method (BEM. Poiseuille and Nusselt numbers were obtained for flows having a different number of geometrical factors. The results are presented and discussed in the form of tables and graphs. The area goodness factor and volume goodness factor are calculated. The predicted correlations for Poiseuille and Nusselt numbers may be a very useful resource for the design and optimization of solar collectors with non-circular ducts.

  14. Investigation of Redistribution of Pile Foundation Forces Under Successive Loading of Its Elements

    Science.gov (United States)

    Sedin, Vladimir; Bikus, Kateryna; Kovba, Vladislav

    2017-12-01

    Redistribution of pile foundation forces under successive loading of its elements was investigated under laboratory conditions. A segment of pile foundation model was taken for use in the case study. Load tests on the pile foundation model segment, without joining its elements (pile and plate, which turns into grillage) and based on different combinations of static loadings were conducted. This proved that the loading of a plate causes skin friction on some length of the pile side surface as well as providing additional loading and settlement. Test results have shown that application of successive elements enables the foundation to carry loads up to 13% higher than in the case of a standard pile foundation loading with the same settlement rates.

  15. Reliability study of Piezoelectric Structures Dedicated to Energy Harvesting by the Way of Blocking Force Investigation

    International Nuclear Information System (INIS)

    Maaroufi, S; Parrain, F; Lefeuvre, E; Boutaud, B; Molin, R Dal

    2015-01-01

    In this paper we propose an approach to study the reliability of piezoelectric structures and more precisely energy harvesting micro-devices dedicated to autonomous active medical implants (new generation pacemakers). The structure under test is designed as a bimorph piezoelectric cantilever with a seismic mass at its tip. Good understanding of material aging and mechanical failure is critical for this kind of system. To study the reliability and durability of the piezoelectric part we propose to establish a new accelerated methodology and an associated test bench where the environment and stimuli can be precisely controlled over a wide period of time. This will allow the identification of potential failure modes and the study of their impacts by the way of direct mechanical investigation based on stiffness and blocking force measurements performed periodically. (paper)

  16. Reliability study of Piezoelectric Structures Dedicated to Energy Harvesting by the Way of Blocking Force Investigation

    Science.gov (United States)

    Maaroufi, S.; Parrain, F.; Lefeuvre, E.; Boutaud, B.; Dal Molin, R.

    2015-12-01

    In this paper we propose an approach to study the reliability of piezoelectric structures and more precisely energy harvesting micro-devices dedicated to autonomous active medical implants (new generation pacemakers). The structure under test is designed as a bimorph piezoelectric cantilever with a seismic mass at its tip. Good understanding of material aging and mechanical failure is critical for this kind of system. To study the reliability and durability of the piezoelectric part we propose to establish a new accelerated methodology and an associated test bench where the environment and stimuli can be precisely controlled over a wide period of time. This will allow the identification of potential failure modes and the study of their impacts by the way of direct mechanical investigation based on stiffness and blocking force measurements performed periodically.

  17. A numerical investigation of laminar forced convection in a solar collector with non-circular duct

    Science.gov (United States)

    Janusz Teleszewski, Tomasz

    2017-11-01

    This paper presents a two-dimensional numerical study to investigate laminar flow in a flat plate solar collector with non-circular duct (regular polygonal, elliptical, and Cassini oval shape) featuring forced convection with constant axial wall heat flux and constant peripheral wall temperature (H1 condition). Applying the velocity profile obtained for the duct laminar flow, the energy equation was solved exactly for the constant wall heat flux using the Boundary Element Method (BEM). Poiseuille and Nusselt numbers were obtained for flows having a different number of geometrical factors. The results are presented and discussed in the form of tables and graphs. The area goodness factor and volume goodness factor are calculated. The predicted correlations for Poiseuille and Nusselt numbers may be a very useful resource for the design and optimization of solar collectors with non-circular ducts.

  18. Substrate binding to SGLT1 investigated by single molecule force spectroscopy

    International Nuclear Information System (INIS)

    Neundlinger, I. J.

    2010-01-01

    D-glucose serves as one of the most important fuels in various organism due to its fundamental role in ATP-, protein and lipid synthesis. Thus, sustaining glucose homeostasis is a crucial issue of life as disorders can cause severe malfunctions such as glucose-galactose-malabsorbtion (GGM). Sodium-glucose co-transporter, SGLTs, especially the high affinity transporter SGLT1, play a crucial role in accumulation of glucose in the cell as they facilitate transport of the sugar into the cytoplasma across the cell membrane by a Na+-electrochemical potential. Even recently, members of the SGLT transporter family have become a therapeutic target for the treatment of hyperglycemia in type 2 diabetes. Hence, it is of particular importance to gain insights on the dynamic behavior of SGLTs during substrate binding and transport across the cell membrane on the single molecular level. In the present study, the Atomic Force Microscope (AFM) was employed to investigate the dynamic properties of the sodium-glucose co-transporter SGLT1 upon substrate binding under nearly physiological conditions. Hereto, new glucose derivatives were synthesized in order to probe the recognition efficiency of these molecules to SGLT1 embedded in the plasma membrane of living cells. A well established coupling protocol was used to covalently link (i) amino-modified D-glucose owning a conserved pyranose ring, (ii) 1-thio-β-D-glucose having a sulphur atom at C1 of the pyranose ring and (iii) the competitive inhibitor phlorizin to the AFM tip via poly(ethylene)glycol (PEG)-tether using different functional end groups and varying lengths. Binding characteristics, e.g. binding probability, interaction forces, influence of substances (glucose, phlorizin, sodium) and of molecule-linker compounds were obtained by performing single molecular recognition force spectroscopy (SMRFS) measurements. Moreover, temperature controlled radioactive binding/transport assays and SMRFS experiments yielded insights into

  19. Investigation of military training injuries in a special force corps in 2011

    Directory of Open Access Journals (Sweden)

    Gang ZHAO

    2013-09-01

    Full Text Available Objective To investigate the incidence, related influencing factors and predilection sites of training injuries in a special force corps for providing a basis of effective prevention of the injuries. Methods Four hundred and sixty-four officers and soldiers were randomly selected by lottery method from a special force corps in May 2011, and the training injuries as well as their related information was investigated by a questionnaire method. The medical records of the 464 subjects from May 2010 to May 2011 were reviewed. The collected data were statistically analyzed using SPSS 19.0 software. Results Of the 464 subjects, 165(35.6% never experienced injuries, and 299(64.4% were injured due to training in the last one year. A total of 505 person-time injuries occurred in 464 subjects, and the incidence of injury was 109 per 100 person-year. The major risk factors for training injuries included above average age, fondness of multiple sports, greater labor force, or higher frequency of sport exercises before enlistment, poor sleep or diet caused by training burden, and higher SCL-90 somatization score. The major protective factors comprised of higher military rank, lower-intensity training, higher education level, higher labor frequency before enlistment, higher SCL-90 phobic anxiety score, higher SCL-90 depression score, SCL-90 spirit score, and higher satisfaction degree on training program. The major sites of training injuries were lower extremities and lower back (accounting for 73.0%. Most injuries occurred below the knee (accounting for 49.0%, including the foot (6.5%, ankle (13.6%, leg(7.3% and knee (21.6%, followed by the lower back (accounting for 20.7%. Conclusions The risk factors of military training injuries involve various aspects, and continuous high intensive and highly difficult training items are the main reason of training injuries, and the lower extremities and lower back are the major locations. Psychological factors are

  20. Hydrogen disposal investigation for the Space Shuttle launch complex at Vandenberg Air Force Base

    Science.gov (United States)

    Breit, Terry J.; Elliott, George

    1987-01-01

    The concern of an overpressure condition on the aft end of the Space Shuttle caused by ignition of unburned hydrogen being trapped in the Space Shuttle Main Engine exhaust duct at the Vandenberg AFB launch complex has been investigated for fifteen months. Approximately twenty-five concepts have been reviewed, with four concepts being thoroughly investigated. The four concepts investigated were hydrogen burnoff ignitors (ignitors located throughout the exhaust duct to continuously ignite any unburned hydrogen), jet mixing (utilizing large volumes of high pressure air to ensure complete combustion of the hydrogen), steam inert (utilizing flashing hot water to inert the duct with steam) and open duct concept (design an open duct or above grade J-deflector to avoid trapping hydrogen gas). Extensive studies, analyses and testing were performed at six test sites with technical support from twenty-two major organizations. In December 1986, the Air Force selected the steam inert concept to be utilized at the Vandenberg launch complex and authorized the design effort.

  1. Investigation of graphite composite anodes surfaces by atomic force microscopy and related techniques

    Energy Technology Data Exchange (ETDEWEB)

    Hirasawa, Karen Akemi; Nishioka, Keiko; Sato, Tomohiro; Yamaguchi, Shoji; Mori, Shoichiro [Mitsubishi Chemical Corp., Tsukuba Research Center, Ibaraki (Japan)

    1997-11-01

    The surface of a synthetic graphite (KS-44) and polyvinylidene difluoride binder (PVDF) anode for lithium-ion secondary batteries is imaged using atomic force microscopy (AFM) and several related scanning probe microscope (SPM) instruments including: dynamic force microscopy (DFM), friction force microscopy (FFM), laterally-modulated friction force microscopy (LM-FFM), visco-elasticity atomic force microscopy (VE-AFM), and AFM/simultaneous current measurement mode (SCM). DFM is found to be an exceptional mode for topographic imaging while FFM results in the clearest contrast distinction between PVDF binder and KS-44 graphite regions. (orig.)

  2. Atomic force imaging microscopy investigation of the interaction of ultraviolet radiation with collagen thin films

    Science.gov (United States)

    Stylianou, A.; Yova, D.; Alexandratou, E.; Petri, A.

    2013-02-01

    Collagen is the major fibrous protein in the extracellular matrix and consists a significant component of skin, bone, cartilage and tendon. Due to its unique properties, it has been widely used as scaffold or culture substrate for tissue regeneration or/and cell-substrate interaction studies. The ultraviolet light-collagen interaction investigations are crucial for the improvement of many applications such as that of the UV irradiation in the field of biomaterials, as sterilizing and photo-cross-linking method. The aim of this paper was to investigate the mechanisms of UV-collagen interactions by developing a collagen-based, well characterized, surface with controlled topography of collagen thin films in the nanoscale range. The methodology was to quantify the collagen surface modification induced on ultraviolet radiation and correlate it with changes induced in cells. Surface nanoscale characterization was performed by Atomic Force Microscopy (AFM) which is a powerful tool and offers quantitative and qualitative information with a non-destructive manner. In order to investigate cells behavior, the irradiated films were used for in vitro cultivation of human skin fibroblasts and the cells morphology, migration and alignment were assessed with fluorescence microscopy imaging and image processing methods. The clarification of the effects of UV light on collagen thin films and the way of cells behavior to the different modifications that UV induced to the collagen-based surfaces will contribute to the better understanding of cell-matrix interactions in the nanoscale and will assist the appropriate use of UV light for developing biomaterials.

  3. Experimental investigation of unsteady fluid dynamic forces acting on tube array

    International Nuclear Information System (INIS)

    Tanaka, Hiroki; Takahara, Shigeru; Tanaka, Mitsutoshi

    1981-01-01

    It is well-known that the cylinder bundle vibrates in cross flow. Many studies of the vibration have been made, and it has been clarified that the vibration is caused by fluid-elastic vibration coupling to neighboring cylinders. The theory given in this paper considers unsteady fluid dynamic forces to be composed of inertia forces due to added mass of fluid, damping forces of fluid which are in phase to cylinder vibrating velocity, and stiffness forces which are proportional to cylinder displacements. Furthermore, taking account of the influences of neighboring cylinder vibrations, ten kinds of unsteady fluid dynamic forces are considered to act on a cylinder in cylinder bundles. Equations of motion of cylinders were deduced and the critical velocities were calculated with the measured unsteady fluid dynamic forces. Critical velocity tests were also conducted with cylinders which were supported with elastic spars. The calculated critical velocities coincided well with the test results. (author)

  4. [Investigating work, age, health and work participation in the ageing work force in Germany].

    Science.gov (United States)

    Ebener, M; Hasselhorn, H M

    2015-04-01

    Working life in Germany is changing. The work force is ageing and the number of people available to the labour market will - from now on - shrink considerably. Prospectively, people will have to work longer; but still today, most people leave employment long before reaching official retirement age. What are the reasons for this? In this report, a conceptual framework and the German lidA Cohort Study are presented. The "lidA conceptual framework on work, age, health and work participation" visualises determinants of employment (11 "domains") in higher working age, e. g., "work", "health", "social status" and "life style". The framework reveals 4 key characteristics of withdrawal from work: leaving working life is the result of an interplay of different domains (complexity); (early) retirement is a process with in part early determinants in the life course (processual character); retirement has a strong individual component (individuality); retirement is embedded in a strong structural frame (structure). On the basis of this framework, the "lidA Cohort Study on work, age, health and work participation" (www.lida-studie.de) investigates long-term effects of work on health and work participation in the ageing work force in Germany. It is the only large study in Germany operationalising the concept of employability in a broad interdisciplinary approach. Employees subject to social security and born in 1959 or in 1965 will be interviewed (CAPI) every 3 years (N[wave 1]=6 585, N[wave 2]=4 244) and their data will be linked (where consented) with social security data covering employment history and with health insurance data. The study design ("Schaie's most efficient design") allows for a tri-factor model that isolates the impact of age, cohort and time. In 2014, the second wave was completed. In the coming years lidA will analyse the association of work, health and work participation, and identify age as well as generation differences. lidA will investigate the

  5. Investigating biomolecular recognition at the cell surface using atomic force microscopy.

    Science.gov (United States)

    Wang, Congzhou; Yadavalli, Vamsi K

    2014-05-01

    Probing the interaction forces that drive biomolecular recognition on cell surfaces is essential for understanding diverse biological processes. Force spectroscopy has been a widely used dynamic analytical technique, allowing measurement of such interactions at the molecular and cellular level. The capabilities of working under near physiological environments, combined with excellent force and lateral resolution make atomic force microscopy (AFM)-based force spectroscopy a powerful approach to measure biomolecular interaction forces not only on non-biological substrates, but also on soft, dynamic cell surfaces. Over the last few years, AFM-based force spectroscopy has provided biophysical insight into how biomolecules on cell surfaces interact with each other and induce relevant biological processes. In this review, we focus on describing the technique of force spectroscopy using the AFM, specifically in the context of probing cell surfaces. We summarize recent progress in understanding the recognition and interactions between macromolecules that may be found at cell surfaces from a force spectroscopy perspective. We further discuss the challenges and future prospects of the application of this versatile technique. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Investigating the dependence of SCM simulated precipitation and clouds on the spatial scale of large-scale forcing at SGP

    Science.gov (United States)

    Tang, Shuaiqi; Zhang, Minghua; Xie, Shaocheng

    2017-08-01

    Large-scale forcing data, such as vertical velocity and advective tendencies, are required to drive single-column models (SCMs), cloud-resolving models, and large-eddy simulations. Previous studies suggest that some errors of these model simulations could be attributed to the lack of spatial variability in the specified domain-mean large-scale forcing. This study investigates the spatial variability of the forcing and explores its impact on SCM simulated precipitation and clouds. A gridded large-scale forcing data during the March 2000 Cloud Intensive Operational Period at the Atmospheric Radiation Measurement program's Southern Great Plains site is used for analysis and to drive the single-column version of the Community Atmospheric Model Version 5 (SCAM5). When the gridded forcing data show large spatial variability, such as during a frontal passage, SCAM5 with the domain-mean forcing is not able to capture the convective systems that are partly located in the domain or that only occupy part of the domain. This problem has been largely reduced by using the gridded forcing data, which allows running SCAM5 in each subcolumn and then averaging the results within the domain. This is because the subcolumns have a better chance to capture the timing of the frontal propagation and the small-scale systems. Other potential uses of the gridded forcing data, such as understanding and testing scale-aware parameterizations, are also discussed.

  7. Computational model to investigate the relative contributions of different neuromuscular properties of tibialis anterior on force generated during ankle dorsiflexion.

    Science.gov (United States)

    Siddiqi, Ariba; Poosapadi Arjunan, Sridhar; Kumar, Dinesh Kant

    2018-01-16

    This study describes a new model of the force generated by tibialis anterior muscle with three new features: single-fiber action potential, twitch force, and pennation angle. This model was used to investigate the relative effects and interaction of ten age-associated neuromuscular parameters. Regression analysis (significance level of 0.05) between the neuromuscular properties and corresponding simulated force produced at the footplate was performed. Standardized slope coefficients were computed to rank the effect of the parameters. The results show that reduction in the average firing rate is the reason for the sharp decline in the force and other factors, such as number of muscle fibers, specific force, pennation angle, and innervation ratio. The fast fiber ratio affects the simulated force through two significant interactions. This study has ranked the individual contributions of the neuromuscular factors to muscle strength decline of the TA and identified firing rate decline as the biggest cause followed by decrease in muscle fiber number and specific force. The strategy for strength preservation for the elderly should focus on improving firing rate. Graphical abstract Neuromuscular properties of Tibialis Anterior on force generated during ankle dorsiflexion.

  8. Experimental investigation on flow instability of forced circulation in a vertical mini-rectangular channel

    International Nuclear Information System (INIS)

    Yu Zhiting; Tan Sichao; Yuan Hongsheng; Zhuang Nailiang; Chen Hanying

    2015-01-01

    An experimental study was conducted to investigate the flow instability in a vertical mini-rectangular channel with distilled water as the working fluid. The rotational speed of the primary pump is gradually reduced to lower the inlet flow rate until the flow becomes unstable, while maintaining all other thermal parameters unchanged. Three types of instability, characterized by large amplitude oscillation, small amplitude oscillation and flow excursion, were identified from the experimental data. A stability map for the vertical mini-rectangular channel under forced circulation was established based on the Subcooling number and Phase Change number. The oscillation periods were correlated with the fluid transit time and the boiling delay time. A flow pattern map for vertical upward flow in a mini-rectangular channel was applied to confirm the flow patterns during the oscillation. The mechanisms of the three types of instability were obtained by considering several types of flow instabilities and comparing them with the oscillations observed in this work. (author)

  9. Numerical investigation of forced convection heat transfer in unsteady flow past a row of square cylinders

    International Nuclear Information System (INIS)

    Chatterjee, Dipankar; Biswas, Gautam; Amiroudine, Sakir

    2009-01-01

    This paper presents the unsteady laminar forced convection heat transfer from a row of five isothermal square cylinders placed in a side-by-side arrangement at a Reynolds number of 150. The numerical simulations are performed using a finite volume code based on the PISO algorithm in a collocated grid system. Special attention is paid to investigate the effect of the spacing between the cylinders on the overall transport processes for the separation ratios (spacing to size ratio) between 0.2 and 10. No significant interaction between the wakes is observed for spacing greater than four times the diameter at this Reynolds number. However, at smaller spacing, the wakes interact in a complicated manner resulting different thermo-hydrodynamic regimes. The vortex structures and isotherm patterns obtained are systematically presented and discussed for different separation ratios. In addition, the mean and instantaneous drag and lift coefficients, mean and local Nusselt number and Strouhal number are determined and discussed for various separation ratios. A new correlation is derived for mean Nusselt number as a function of separation ratio for such flows.

  10. Force spectroscopy of collagen fibers to investigate their mechanical properties and structural organization.

    Science.gov (United States)

    Gutsmann, Thomas; Fantner, Georg E; Kindt, Johannes H; Venturoni, Manuela; Danielsen, Signe; Hansma, Paul K

    2004-05-01

    Tendons are composed of collagen and other molecules in a highly organized hierarchical assembly, leading to extraordinary mechanical properties. To probe the cross-links on the lower level of organization, we used a cantilever to pull substructures out of the assembly. Advanced force probe technology, using small cantilevers (length exponential increase in force and two different periodic rupture events, one with strong bonds (jumps in force of several hundred pN) with a periodicity of 78 nm and one with weak bonds (jumps in force of <7 pN) with a periodicity of 22 nm. We demonstrate a good correlation between the measured mechanical behavior of collagen fibers and their appearance in the micrographs taken with the atomic force microscope.

  11. Nanoscale investigation on Pseudomonas aeruginosa biofilm formed on porous silicon using atomic force microscopy.

    Science.gov (United States)

    Kannan, Ashwin; Karumanchi, Subbalakshmi Latha; Krishna, Vinatha; Thiruvengadam, Kothai; Ramalingam, Subramaniam; Gautam, Pennathur

    2014-01-01

    Colonization of surfaces by bacterial cells results in the formation of biofilms. There is a need to study the factors that are important for formation of biofilms since biofilms have been implicated in the failure of semiconductor devices and implants. In the present study, the adhesion force of biofilms (formed by Pseudomonas aeruginosa) on porous silicon substrates of varying surface roughness was quantified using atomic force microscopy (AFM). The experiments were carried out to quantify the effect of surface roughness on the adhesion force of biofilm. The results show that the adhesion force increased from 1.5 ± 0.5 to 13.2 ± 0.9 nN with increase in the surface roughness of silicon substrate. The results suggest that the adhesion force of biofilm is affected by surface roughness of substrate. © 2014 Wiley Periodicals, Inc.

  12. An investigation of shoulder forces in active shoulder tackles in rugby union football.

    Science.gov (United States)

    Usman, Juliana; McIntosh, Andrew S; Fréchède, Bertrand

    2011-11-01

    In rugby union football the tackle is the most frequently executed skill and one most associated with injury, including shoulder injury to the tackler. Despite the importance of the tackle, little is known about the magnitude of shoulder forces in the tackle and influencing factors. The objectives of the study were to measure the shoulder force in the tackle, as well as the effects of shoulder padding, skill level, side of body, player size, and experimental setting on shoulder force. Experiments were conducted in laboratory and field settings using a repeated measures design. Thirty-five participants were recruited to the laboratory and 98 to the field setting. All were male aged over 18 years with rugby experience. The maximum force applied to the shoulder in an active shoulder tackle was measured with a custom built forceplate incorporated into a 45 kg tackle bag. The overall average maximum shoulder force was 1660 N in the laboratory and 1997 N in the field. This difference was significant. The shoulder force for tackling without shoulder pads was 1684 N compared to 1635 N with shoulder pads. There was no difference between the shoulder forces on the dominant and non-dominant sides. Shoulder force reduced with tackle repetition. No relationship was observed between player skill level and size. A substantial force can be applied to the shoulder and to an opponent in the tackle. This force is within the shoulder's injury tolerance range and is unaffected by shoulder pads. Copyright © 2011 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  13. Investigation of the heparin-thrombin interaction by dynamic force spectroscopy.

    Science.gov (United States)

    Wang, Congzhou; Jin, Yingzi; Desai, Umesh R; Yadavalli, Vamsi K

    2015-06-01

    The interaction between heparin and thrombin is a vital step in the blood (anti)coagulation process. Unraveling the molecular basis of the interactions is therefore extremely important in understanding the mechanisms of this complex biological process. In this study, we use a combination of an efficient thiolation chemistry of heparin, a self-assembled monolayer-based single molecule platform, and a dynamic force spectroscopy to provide new insights into the heparin-thrombin interaction from an energy viewpoint at the molecular scale. Well-separated single molecules of heparin covalently attached to mixed self-assembled monolayers are demonstrated, whereby interaction forces with thrombin can be measured via atomic force microscopy-based spectroscopy. Further these interactions are studied at different loading rates and salt concentrations to directly obtain kinetic parameters. An increase in the loading rate shows a higher interaction force between the heparin and thrombin, which can be directly linked to the kinetic dissociation rate constant (koff). The stability of the heparin/thrombin complex decreased with increasing NaCl concentration such that the off-rate was found to be driven primarily by non-ionic forces. These results contribute to understanding the role of specific and nonspecific forces that drive heparin-thrombin interactions under applied force or flow conditions. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. Thermodynamic investigation and optimization of laminar forced convection in a rotating helical tube heat exchanger

    International Nuclear Information System (INIS)

    Shi, Zhongyuan; Dong, Tao

    2014-01-01

    Highlights: • Variation of total entropy generation is investigated parametrically. • Pareto solution sets for heat transfer and flow friction components are obtained. • Dominant irreversibility component and impact of key variables are discussed. - Abstract: Based on the second law of thermodynamics, an entropy generation investigation is carried out under given dimensionless parameters, i.e. heat exchanger duty, heat flux, with respect to heat transfer and frictional pressure drop in a rotating helical tube heat exchanger with laminar convective flow. The entropy generation from heat transfer across a finite temperature difference – Ψ h decreases with increasing Dean number which represents the impact of centrifugal force induced secondary flow in enhancing heat transfer. Another aspect of increasing Dean number is that intensified momentum transfer in the radial direction also raises the entropy generation from frictional pressure drop – Ψ f , the superposed effect of which yields a decreasing–increasing trend of the total entropy generation-Ψ, a local minimum located in between. The rotation of the helical tube in streamwise (co-rotation) or counter streamwise (counter-rotation) direction leads to a decrease in Ψ h and a increase in Ψ f which complicates the situation that whether or where the minimum of total entropy generation exists is dependent on whether Ψ is dominated by Ψ h or Ψ f or somewhere in between. No difference is discerned between pairs of cases with constant wall temperature and uniform wall heat flux but the same set of variables and parameters. A multi-objective optimization targeting Ψ h and Ψ f simultaneously is implemented using the non-dominated sorting genetic algorithm II (NSGA II). Five solution sets are selected and compared with the conventional optimization in regard of Ψ distinguishing the Ψ h -dominated region from the Ψ f -dominated region, the dimensionless variable η 1 is found to be the most suitable

  15. Does an increase in compression force really improve visual image quality in mammography? – An initial investigation

    International Nuclear Information System (INIS)

    Mercer, C.E.; Hogg, P.; Cassidy, S.; Denton, E.R.E.

    2013-01-01

    Objective: Literature speculates that visual image quality (IQ) and compression force levels may be directly related. This small study investigates whether a relationship exists between compression force levels and visual IQ. Method: To investigate how visual IQ varies with different levels of compression force, 39 clients were selected over a 6 year screening period that had received markedly different amounts of compression force on each of their three sequential screens. Images for the 3 screening episodes for all women were scored visually using 3 different IQ scales. Results: Correlation coefficients between the 3 IQ scales were positive and high (0.82, 0.9 and 0.85). For the scales, the IQ scores their correlation does not vary significantly, even though different compression levels had been applied. Kappa IQ scale 1: 0.92, 0.89, 0.89. ANOVA IQ scale 2: p = 0.98, p = 0.55, p = 0.56. ICC IQ scale 3: 0.97, 0.93, 0.91. Conclusion: For the 39 clients there is no difference in visual IQ when different amounts of compression are applied. We believe that further work should be conducted into compression force and image quality as ‘higher levels’ of compression force may not be justified in the attainment of suitable visual image quality

  16. Geologic investigation :an update of subsurface geology on Kirtland Air Force Base, New Mexico.

    Energy Technology Data Exchange (ETDEWEB)

    Van Hart, Dirk (GRAM, Inc.)

    2003-06-01

    The objective of this investigation was to generate a revised geologic model of Kirtland Air Force Base (KAFB) incorporating the geological and geophysical data produced since the Site-Wide Hydrogeologic Characterization Project (SWHC) of 1994 and 1995. Although this report has certain stand-alone characteristics, it is intended to complement the previous work and to serve as a status report as of late 2002. In the eastern portion of KAFB (Lurance Canyon and the Hubbell bench), of primary interest is the elevation to which bedrock is buried under a thin cap of alluvium. Elevation maps of the bedrock top reveal the paleodrainage that allows for the interpretation of the area's erosional history. The western portion of KAFB consists of the eastern part of the Albuquerque basin where bedrock is deeply buried under Santa Fe Group alluvium. In this area, the configuration of the down-to-the-west, basin-bounding Sandia and West Sandia faults is of primary interest. New geological and geophysical data and the reinterpretation of old data help to redefine the location and magnitude of these elements. Additional interests in this area are the internal stratigraphy and structure of the Santa Fe Group. Recent data collected from new monitoring wells in the area have led to a geologic characterization of the perched Tijeras Arroyo Groundwater system and have refined the known limits of the Ancestral Rio Grande fluvial sediments within the Santa Fe Group. Both the reinterpretation of the existing data and a review of the regional geology have shown that a segment of the boundary between the eastern and western portions of KAFB is a complicated early Tertiary (Laramide) wrench-fault system, the Tijeras/Explosive Ordnance Disposal Area/Hubbell Spring system. A portion of this fault zone is occupied by a coeval ''pull-apart'' basin filled with early Tertiary conglomerates, whose exposures form the ''Travertine Hills''.

  17. Investigation of polymer derived ceramics cantilevers for application of high speed atomic force microscopy

    Science.gov (United States)

    Wu, Chia-Yun

    High speed Atomic Force Microscopy (AFM) has a wide variety of applications ranging from nanomanufacturing to biophysics. In order to have higher scanning speed of certain AFM modes, high resonant frequency cantilevers are needed; therefore, the goal of this research is to investigate using polymer derived ceramics for possible applications in making high resonant frequency AFM cantilevers using complex cross sections. The polymer derived ceramic that will be studied, is silicon carbide. Polymer derived ceramics offer a potentially more economic fabrication approach for MEMS due to their relatively low processing temperatures and ease of complex shape design. Photolithography was used to make the desired cantilever shapes with micron scale size followed by a wet etching process to release the cantilevers from the substrates. The whole manufacturing process we use borrow well-developed techniques from the semiconducting industry, and as such this project also could offer the opportunity to reduce the fabrication cost of AFM cantilevers and MEMS in general. The characteristics of silicon carbide made from the precursor polymer, SMP-10 (Starfire Systems), were studied. In order to produce high qualities of silicon carbide cantilevers, where the major concern is defects, proper process parameters needed to be determined. Films of polymer derived ceramics often have defects due to shrinkage during the conversion process. Thus control of defects was a central issue in this study. A second, related concern was preventing oxidation; the polymer derived ceramics we chose is easily oxidized during processing. Establishing an environment without oxygen in the whole process was a significant challenge in the project. The optimization of the parameters for using photolithography and wet etching process was the final and central goal of the project; well established techniques used in microfabrication were modified for use in making the cantilever in the project. The techniques

  18. Quantitative nanohistological investigation of scleroderma: an atomic force microscopy-based approach to disease characterization

    Directory of Open Access Journals (Sweden)

    Strange AP

    2017-01-01

    Full Text Available Adam P Strange,1 Sebastian Aguayo,1 Tarek Ahmed,1 Nicola Mordan,1 Richard Stratton,2 Stephen R Porter,3 Susan Parekh,4 Laurent Bozec1 1Department of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 2Centre for Rheumatology and Connective Tissue Diseases, Royal Free Hospital, UCL Medical School, 3UCL Eastman Dental Institute, 4Department of Pediatrics, UCL Eastman Dental Institute, London, UK Abstract: Scleroderma (or systemic sclerosis, SSc is a disease caused by excess crosslinking of collagen. The skin stiffens and becomes painful, while internally, organ function can be compromised by the less elastic collagen. Diagnosis of SSc is often only possible in advanced cases by which treatment time is limited. A more detailed analysis of SSc may provide better future treatment options and information of disease progression. Recently, the histological stain picrosirius red showing collagen register has been combined with atomic force microscopy (AFM to study SSc. Skin from healthy individuals and SSc patients was biopsied, stained and studied using AFM. By investigating the crosslinking of collagen at a smaller hierarchical stage, the effects of SSc were more pronounced. Changes in morphology and Young’s elastic modulus were observed and quantified; giving rise to a novel technique, we have termed “quantitative nanohistology”. An increase in nanoscale stiffness in the collagen for SSc compared with healthy individuals was seen by a significant increase in the Young’s modulus profile for the collagen. These markers of stiffer collagen in SSc are similar to the symptoms experienced by patients, giving additional hope that in the future, nanohistology using AFM can be readily applied as a clinical tool, providing detailed information of the state of collagen. Keywords: rheumatology, adjunct diagnosis, picrosirius red, collagen, nanohistology

  19. (Environmental investigation of ground water contamination at Wright-Patterson Air Force Base, Ohio)

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-01

    This report presents information concerning field procedures employed during the monitoring, well construction, well purging, sampling, and well logging at the Wright-Patterson Air Force Base. Activities were conducted in an effort to evaluate ground water contamination.

  20. An investigation of rugby scrimmaging posture and individual maximum pushing force.

    Science.gov (United States)

    Wu, Wen-Lan; Chang, Jyh-Jong; Wu, Jia-Hroung; Guo, Lan-Yuen

    2007-02-01

    Although rugby is a popular contact sport and the isokinetic muscle torque assessment has recently found widespread application in the field of sports medicine, little research has examined the factors associated with the performance of game-specific skills directly by using the isokinetic-type rugby scrimmaging machine. This study is designed to (a) measure and observe the differences in the maximum individual pushing forward force produced by scrimmaging in different body postures (3 body heights x 2 foot positions) with a self-developed rugby scrimmaging machine and (b) observe the variations in hip, knee, and ankle angles at different body postures and explore the relationship between these angle values and the individual maximum pushing force. Ten national rugby players were invited to participate in the examination. The experimental equipment included a self-developed rugby scrimmaging machine and a 3-dimensional motion analysis system. Our results showed that the foot positions (parallel and nonparallel foot positions) do not affect the maximum pushing force; however, the maximum pushing force was significantly lower in posture I (36% body height) than in posture II (38%) and posture III (40%). The maximum forward force in posture III (40% body height) was also slightly greater than for the scrum in posture II (38% body height). In addition, it was determined that hip, knee, and ankle angles under parallel feet positioning are factors that are closely negatively related in terms of affecting maximum pushing force in scrimmaging. In cross-feet postures, there was a positive correlation between individual forward force and hip angle of the rear leg. From our results, we can conclude that if the player stands in an appropriate starting position at the early stage of scrimmaging, it will benefit the forward force production.

  1. Investigation of lateral forces in dynamic mode using combined AFM/STM

    OpenAIRE

    Atabak, Mehrdad

    2007-01-01

    Ankara : The Department of Physics and The Institute of Engineering and Science of Bilkent University, 2007. Thesis (Ph.D.) -- Bilkent University, 2007. Includes bibliographical references leaves 114-126. In this Ph.D. work, we constructed a ¯ber optic interferometer based non-contact Atomic Force Microscope (nc-AFM) combined with Scanning Tunneling Micro- scope(STM) to study lateral force interactions on Si(111)-(77) surface. The in- terferometer has been built in such a wa...

  2. Investigation of a cuboidal permanent magnet’s force exerted on a robotic capsule

    Directory of Open Access Journals (Sweden)

    Yang W

    2014-08-01

    Full Text Available Wan’an Yang,1 Chengbing Tang,2 Fengqing Qin1 1School of Computer and Information Engineering, Yibin University, Yibin, 2CNPC Chuanqing Geophysical Prospecting Company Research Center Computer Department, Chengdu, Sichuan, People’s Republic of China Abstract: To control and drive a robotic capsule accurately from outside a patient’s body, we present a schema in which the capsule enclosing the imaging device, circuits, batteries, etc is looped by a permanent magnet ring that acts as an actuator. A cuboidal permanent magnet situated outside the patient's body attracts or pushes the magnet ring from different directions to make the capsule move or rotate. A mathematic model of attractive or repulsive force that the cuboidal magnet exerts on the magnet ring is presented for accurate calculation of force. The experiments showed that the measuring force was in agreement with the theoretical one, and the relations between the dimensions of the cuboidal magnet and force are useful to produce a cuboidal magnet with optimal shape to get appropriate force. Keywords: control and drive, robotic capsule, permanent magnet ring, optimal dimension, force model

  3. [Environmental investigation of ground water contamination at Wright- Patterson Air Force Base, Ohio]. Volume 4, Health and Safety Plan (HSP); Phase 1, Task 4 Field Investigation report: Draft

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-01

    This Health and Safety Plan (HSP) was developed for the Environmental Investigation of Ground-water Contamination Investigation at Wright-Patterson Air Force Base near Dayton, Ohio, based on the projected scope of work for the Phase 1, Task 4 Field Investigation. The HSP describes hazards that may be encountered during the investigation, assesses the hazards, and indicates what type of personal protective equipment is to be used for each task performed. The HSP also addresses the medical monitoring program, decontamination procedures, air monitoring, training, site control, accident prevention, and emergency response.

  4. Investigation of force, contact area, and dwell time in finger-tapping tasks on membrane touch interface.

    Science.gov (United States)

    Liu, Na; Yu, Ruifeng

    2018-06-01

    This study aimed to determine the touch characteristics during tapping tasks on membrane touch interface and investigate the effects of posture and gender on touch characteristics variables. One hundred participants tapped digits displayed on a membrane touch interface on sitting and standing positions using all fingers of the dominant hand. Touch characteristics measures included average force, contact area, and dwell time. Across fingers and postures, males exerted larger force and contact area than females, but similar dwell time. Across genders and postures, thumb exerted the largest force and the force of the other four fingers showed no significant difference. The contact area of the thumb was the largest, whereas that of the little finger was the smallest; the dwell time of the thumb was the longest, whereas that of the middle finger was the shortest. Relationships among finger sizes, gender, posture and touch characteristics were proposed. The findings helped direct membrane touch interface design for digital and numerical control products from hardware and software perspectives. Practitioner Summary: This study measured force, contact area, and dwell time in tapping tasks on membrane touch interface and examined effects of gender and posture on force, contact area, and dwell time. The findings will direct membrane touch interface design for digital and numerical control products from hardware and software perspectives.

  5. Cogging force investigation of a free piston permanent magnet linear generator

    Science.gov (United States)

    Abdalla, I. I.; Zainal, A. E. Z.; Ramlan, N. A.; Firmansyah; Aziz, A. R. A.; Heikal, M. R.

    2017-10-01

    Better performance and higher efficiency of the vehicles can be achieved by using free piston engine, in which the piston is connected directly to the linear generator and waiving of any mechanical means. The free piston engine has the ability to overcome or reduce many of the challenges, such as the carbon dioxide (CO2) emission and fossil fuel consumption. The cogging force produces undesired vibration and acoustic noise in the generator. However, the cogging force must be minimized as much as possible, in order to have a high performance. This paper studies the effects of ferromagnetic materials on the cogging force of the permanent magnet linear generator (PMLG) to be used in a free piston engine using nonlinear finite-element analysis (FEA) under ANSYS Maxwell. The comparisons have been established for the cogging force of the PMLG under various translator velocities and three different ferromagnetic materials for the stator core, namely, Silicon Steel laminations, Mild Steel and Somaloy. It has been shown that the PMLG with a stator core made of Somaloy has a lower cogging force among them. Furthermore, the induced voltage of the PMLG at different accelerations has been studied. It is found that the PMLG with Mild Steel and Somaloy, respectively give larger induced voltage. Moreover, as the translator speed increase the induced voltage increased.

  6. Air Force Health Study. An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. First Followup Examination Results. Volume 1

    Science.gov (United States)

    1987-10-01

    include actinic elastosis,,ape scars, disfigurement, excessive hair growth , and Peyronie’s disease. Severe chloracne is often accom- panied by acute...differences between the Ranch vii Hands and the Comparisons, and these differances vera not traditional indi- cators of dioxin-related disease. Both the...Investigation Dioxis* alo Sadmilfr-iis&R"Bn 05bi 40 ormang Air Force Nealta Study Morbidity * tG* 1 AI IA C8000 so *wow 4440" O*e*MV IVea =7Win ee-" * This

  7. Fundamental investigation on interaction forces in bubble swarms and its application to the design of centrifugal separators

    International Nuclear Information System (INIS)

    Wisman, R.

    1979-01-01

    The present investigation deals with two aspects of gas-liquid flows, viz. interaction forces between the phases in bubble swarms and numerical description of rotating gas-liquid flows. The insight obtained was applied to the development of axial gas-liquid cyclones, as used i.a. as primary separators in nuclear boiling water reactors. (Auth.)

  8. Experimental Investigation of the Effect of Burnishing Force on Service Properties of AISI 1010 Steel Plates

    Science.gov (United States)

    Gharbi, F.; Sghaier, S.; Morel, F.; Benameur, T.

    2015-02-01

    This paper presents the results obtained with a new ball burnishing tool developed for the mechanical treatment of large flat surfaces. Several parameters can affect the mechanical behavior and fatigue of workpiece. Our study focused on the effect of the burnishing force on the surface quality and on the service properties (mechanical behavior, fatigue) of AISI 1010 steel hot-rolled plates. Experimental results assert that burnishing force not exceeding 300 N causes an increase in the ductility. In addition, results indicated that the effect of the burnishing force on the residual surface stress was greater in the direction of advance than in the cross-feed direction. Furthermore, the flat burnishing surfaces did not improve the fatigue strength of AISI 1010 steel flat specimens.

  9. Investigation of Unbalanced Magnetic Force in Magnetic Geared Machine Using Analytical Methods

    DEFF Research Database (Denmark)

    Zhang, Xiaoxu; Liu, Xiao; Chen, Zhe

    2016-01-01

    The electromagnetic structure of the magnetic geared machine (MGM) may induce a significant unbalanced magnetic force (UMF). However, few methods have been developed to theoretically reveal the essential reasons for this issue in the MGM. In this paper, an analytical method based on an air....... Second, the magnetic field distribution in the MGM is modeled by an exact subdomain method, which allows the magnetic forces to be calculated quantitatively. The magnetic forces in two MGMs are then studied under no-load and full-load conditions. Finally, the finite-element calculation confirms......-gap relative permeance theory is first developed to qualitatively study the origins of the UMF in the MGM. By means of formula derivations, three kinds of magnetic field behaviors in the air gaps are found to be the potential sources of UMF. It is also proved that the UMF is possible to avoid by design choices...

  10. Human airway epithelial cells investigated by atomic force microscopy: A hint to cystic fibrosis epithelial pathology

    Energy Technology Data Exchange (ETDEWEB)

    Lasalvia, Maria [Department of Clinical and Experimental Medicine, University of Foggia, Foggia (Italy); Istituto Nazionale di Fisica Nucleare, Sezione di Bari, Bari (Italy); Castellani, Stefano [Department of Medical and Surgical Sciences, University of Foggia, Foggia (Italy); D’Antonio, Palma [Department of Clinical and Experimental Medicine, University of Foggia, Foggia (Italy); Perna, Giuseppe [Department of Clinical and Experimental Medicine, University of Foggia, Foggia (Italy); Istituto Nazionale di Fisica Nucleare, Sezione di Bari, Bari (Italy); Carbone, Annalucia [Department of Medical and Surgical Sciences, University of Foggia, Foggia (Italy); Colia, Anna Laura; Maffione, Angela Bruna [Department of Clinical and Experimental Medicine, University of Foggia, Foggia (Italy); Capozzi, Vito [Department of Clinical and Experimental Medicine, University of Foggia, Foggia (Italy); Istituto Nazionale di Fisica Nucleare, Sezione di Bari, Bari (Italy); Conese, Massimo, E-mail: massimo.conese@unifg.it [Department of Medical and Surgical Sciences, University of Foggia, Foggia (Italy)

    2016-10-15

    The pathophysiology of cystic fibrosis (CF) airway disease stems from mutations in the CF Transmembrane Conductance Regulator (CFTR) gene, leading to a chronic respiratory disease. Actin cytoskeleton is disorganized in CF airway epithelial cells, likely contributing to the CF-associated basic defects, i.e. defective chloride secretion and sodium/fluid hypersorption. In this work, we aimed to find whether this alteration could be pointed out by means of Atomic Force Microscopy (AFM) investigation, as roughness and Young's elastic module. Moreover, we also sought to determine whether disorganization of actin cytoskeleton is linked to hypersoption of apical fluid. Not only CFBE41o- (CFBE) cells, immortalized airway epithelial cells homozygous for the F508del CFTR allele, showed a different morphology in comparison with 16HBE14o- (16HBE) epithelial cells, wild-type for CFTR, but also they displayed a lack of stress fibers, suggestive of a disorganized actin cytoskeleton. AFM measurements showed that CFBE cells presented a higher membrane roughness and decreased rigidity as compared with 16HBE cells. CFBE overexpressing wtCFTR became more elongated than the parental CFBE cell line and presented actin stress fibers. CFBE cells absorbed more fluid from the apical compartment. Study of fluid absorption with the F-actin-depolymerizing agent Latrunculin B demonstrated that actin cytoskeletal disorganization increased fluid absorption, an effect observed at higher magnitude in 16HBE than in CFBE cells. For the first time, we demonstrate that actin cytoskeleton disorganization is reflected by AFM parameters in CF airway epithelial cells. Our data also strongly suggest that the lack of stress fibers is involved in at least one of the early step in CF pathophysiology at the levels of the airways, i.e. fluid hypersorption. - Highlights: • CF bronchial epithelial (CFBE) cells show a disorganized actin cytoskeleton. • CFBE cells present high roughness and low rigidity in

  11. Human airway epithelial cells investigated by atomic force microscopy: A hint to cystic fibrosis epithelial pathology

    International Nuclear Information System (INIS)

    Lasalvia, Maria; Castellani, Stefano; D’Antonio, Palma; Perna, Giuseppe; Carbone, Annalucia; Colia, Anna Laura; Maffione, Angela Bruna; Capozzi, Vito; Conese, Massimo

    2016-01-01

    The pathophysiology of cystic fibrosis (CF) airway disease stems from mutations in the CF Transmembrane Conductance Regulator (CFTR) gene, leading to a chronic respiratory disease. Actin cytoskeleton is disorganized in CF airway epithelial cells, likely contributing to the CF-associated basic defects, i.e. defective chloride secretion and sodium/fluid hypersorption. In this work, we aimed to find whether this alteration could be pointed out by means of Atomic Force Microscopy (AFM) investigation, as roughness and Young's elastic module. Moreover, we also sought to determine whether disorganization of actin cytoskeleton is linked to hypersoption of apical fluid. Not only CFBE41o- (CFBE) cells, immortalized airway epithelial cells homozygous for the F508del CFTR allele, showed a different morphology in comparison with 16HBE14o- (16HBE) epithelial cells, wild-type for CFTR, but also they displayed a lack of stress fibers, suggestive of a disorganized actin cytoskeleton. AFM measurements showed that CFBE cells presented a higher membrane roughness and decreased rigidity as compared with 16HBE cells. CFBE overexpressing wtCFTR became more elongated than the parental CFBE cell line and presented actin stress fibers. CFBE cells absorbed more fluid from the apical compartment. Study of fluid absorption with the F-actin-depolymerizing agent Latrunculin B demonstrated that actin cytoskeletal disorganization increased fluid absorption, an effect observed at higher magnitude in 16HBE than in CFBE cells. For the first time, we demonstrate that actin cytoskeleton disorganization is reflected by AFM parameters in CF airway epithelial cells. Our data also strongly suggest that the lack of stress fibers is involved in at least one of the early step in CF pathophysiology at the levels of the airways, i.e. fluid hypersorption. - Highlights: • CF bronchial epithelial (CFBE) cells show a disorganized actin cytoskeleton. • CFBE cells present high roughness and low rigidity in the

  12. Investigation on forces in frictional kinematic pairs to assess their influence on shock absorber characteristics

    Directory of Open Access Journals (Sweden)

    Janusz GARDULSKI

    2008-01-01

    Full Text Available In telescopic shock absorbers there are two kinematic pairs where dry,semi-dry or fluid friction is most likely to occur. Higher values of friction forces are noted in piston rod-slideway pair due to its sealing function and consequently worse lubricating conditions. The aim of the tests was to assess the influence of forces occurring in frictional kinematic pairs on damping characteristics of shock absorbers. The tests were performed on new and fluid-free shock absorbers for various working strokes and various extortion frequencies.

  13. Langmuir- Blodgett layers of amphiphilic molecules investigated by Atomic Force Microscopy

    NARCIS (Netherlands)

    Zdravkova, Aneliya Nikolova

    2007-01-01

    Langmuir - Blodgett technique and Atomic Force Microscopy were used to study the phase behaviour of organic molecules (fatty alcohols and monoacid saturated triglycerides) at air-water and air-solid interfaces. The structure of binary mixed LB monolayers of fatty alcohols was reported. The

  14. Force Spectroscopy of Collagen Fibers to Investigate Their Mechanical Properties and Structural Organization

    OpenAIRE

    Gutsmann, Thomas; Fantner, Georg E.; Kindt, Johannes H.; Venturoni, Manuela; Danielsen, Signe; Hansma, Paul K.

    2004-01-01

    Tendons are composed of collagen and other molecules in a highly organized hierarchical assembly, leading to extraordinary mechanical properties. To probe the cross-links on the lower level of organization, we used a cantilever to pull substructures out of the assembly. Advanced force probe technology, using small cantilevers (length

  15. The Force of Gardening: Investigating Children's Learning in a Food Garden

    Science.gov (United States)

    Green, Monica; Duhn, Iris

    2015-01-01

    School gardens are becoming increasingly recognised as important sites for learning and for bringing children into relationship with food. Despite the well-known educational and health benefits of gardening, children's interactions with the non-human entities and forces within garden surroundings are less understood and examined in the wider…

  16. Investigation of Body Force Effects on Flow Boiling Critical Heat Flux

    Science.gov (United States)

    Zhang, Hui; Mudawar, Issam; Hasan, Mohammad M.

    2002-01-01

    The bubble coalescence and interfacial instabilities that are important to modeling critical heat flux (CHF) in reduced-gravity systems can be sensitive to even minute body forces. Understanding these complex phenomena is vital to the design and safe implementation of two-phase thermal management loops proposed for space and planetary-based thermal systems. While reduced gravity conditions cannot be accurately simulated in 1g ground-based experiments, such experiments can help isolate the effects of the various forces (body force, surface tension force and inertia) which influence flow boiling CHF. In this project, the effects of the component of body force perpendicular to a heated wall were examined by conducting 1g flow boiling experiments at different orientations. FC-72 liquid was boiled along one wall of a transparent rectangular flow channel that permitted photographic study of the vapor-liquid interface at conditions approaching CHF. High-speed video imaging was employed to capture dominant CHF mechanisms. Six different CHF regimes were identified: Wavy Vapor Layer, Pool Boiling, Stratification, Vapor Counterflow, Vapor Stagnation, and Separated Concurrent Vapor Flow. CHF showed great sensitivity to orientation for flow velocities below 0.2 m/s, where very small CHF values where measured, especially with downflow and downward-facing heated wall orientations. High flow velocities dampened the effects of orientation considerably. Figure I shows representative images for the different CHF regimes. The Wavy Vapor Layer regime was dominant for all high velocities and most orientations, while all other regimes were encountered at low velocities, in the downflow and/or downward-facing heated wall orientations. The Interfacial Lift-off model was modified to predict the effects of orientation on CHF for the dominant Wavy Vapor Layer regime. The photographic study captured a fairly continuous wavy vapor layer travelling along the heated wall while permitting liquid

  17. Investigating the influence of anthropogenic forcing on observed mean and extreme sea level pressure trends over the Mediterranean Region.

    Science.gov (United States)

    Barkhordarian, Armineh

    2012-01-01

    We investigate whether the observed mean sea level pressure (SLP) trends over the Mediterranean region in the period from 1975 to 2004 are significantly consistent with what 17 models projected as response of SLP to anthropogenic forcing (greenhouse gases and sulphate aerosols, GS). Obtained results indicate that the observed trends in mean SLP cannot be explained by natural (internal) variability. Externally forced changes are detectable in all seasons, except spring. The large-scale component (spatial mean) of the GS signal is detectable in all the 17 models in winter and in 12 of the 17 models in summer. However, the small-scale component (spatial anomalies about the spatial mean) of GS signal is only detectable in winter within 11 of the 17 models. We also show that GS signal has a detectable influence on observed decreasing (increasing) tendency in the frequencies of extremely low (high) SLP days in winter and that these changes cannot be explained by internal climate variability. While the detection of GS forcing is robust in winter and summer, there are striking inconsistencies in autumn, where analysis points to the presence of an external forcing, which is not GS forcing.

  18. A combined optical and atomic force microscope for live cell investigations

    Energy Technology Data Exchange (ETDEWEB)

    Madl, Josef [Institute for Biophysics, Johannes Kepler University Linz, Altenbergerstr. 69, 4040 Linz (Austria); Rhode, Sebastian [Institute for Biophysics, Johannes Kepler University Linz, Altenbergerstr. 69, 4040 Linz (Austria); Stangl, Herbert [Institute for Medical Chemistry, Medical University Vienna, Waehringerstr. 10, 1090 Vienna (Austria); Stockinger, Hannes [Department of Molecular Immunology, Center for Biomolecular Medicine and Pharmacology, Medical University Vienna, Lazarettgasse 19, 1090 Vienna (Austria); Hinterdorfer, Peter [Institute for Biophysics, Johannes Kepler University Linz, Altenbergerstr. 69, 4040 Linz (Austria); Schuetz, Gerhard J. [Institute for Biophysics, Johannes Kepler University Linz, Altenbergerstr. 69, 4040 Linz (Austria); Kada, Gerald [Scientec, Mitterbauerweg 4, 4020 Linz (Austria)]. E-mail: gerald_kada@agilent.com

    2006-06-15

    We present an easy-to-use combination of an atomic force microscope (AFM) and an epi-fluorescence microscope, which allows live cell imaging under physiological conditions. High-resolution AFM images were acquired while simultaneously monitoring either the fluorescence image of labeled membrane components, or a high-contrast optical image (DIC, differential interference contrast). By applying two complementary techniques at the same time, additional information and correlations between structure and function of living organisms were obtained. The synergy effects between fluorescence imaging and AFM were further demonstrated by probing fluorescence-labeled receptor clusters in the cell membrane via force spectroscopy using antibody-functionalized tips. The binding probability on receptor-containing areas identified with fluorescence microscopy ('receptor-positive sites') was significantly higher than that on sites lacking receptors.

  19. A combined optical and atomic force microscope for live cell investigations

    International Nuclear Information System (INIS)

    Madl, Josef; Rhode, Sebastian; Stangl, Herbert; Stockinger, Hannes; Hinterdorfer, Peter; Schuetz, Gerhard J.; Kada, Gerald

    2006-01-01

    We present an easy-to-use combination of an atomic force microscope (AFM) and an epi-fluorescence microscope, which allows live cell imaging under physiological conditions. High-resolution AFM images were acquired while simultaneously monitoring either the fluorescence image of labeled membrane components, or a high-contrast optical image (DIC, differential interference contrast). By applying two complementary techniques at the same time, additional information and correlations between structure and function of living organisms were obtained. The synergy effects between fluorescence imaging and AFM were further demonstrated by probing fluorescence-labeled receptor clusters in the cell membrane via force spectroscopy using antibody-functionalized tips. The binding probability on receptor-containing areas identified with fluorescence microscopy ('receptor-positive sites') was significantly higher than that on sites lacking receptors

  20. Preliminary investigation of predictors of the cutting forces for some South African coals

    Energy Technology Data Exchange (ETDEWEB)

    MacGregor, I M; Baker, D R

    1985-08-01

    This paper discusses the possible use of petrological data and proximate analyses in the prediction of cutting forces for coal. It is restricted to the development of univariate predictors based on data from thirteen collieries in five major Transvaal and Orange Free State coalfields and three coal provinces. The aim of the work was the identification and development of the best predictors of mean peak cutting force and Hardgrove grindability index from among the independent variables evaluated. The data were processed according to the SPSS computer package. The analysis revealed reasonable correlations between the Hardgrove grindability index and (1) the volatiles and vitrinite content in the Vereeniging-Sasolburg and South Rand Coalfields, (2) the contents of vitrinite, vitrinite plus exinite, and minerals plus inertinite in the Eastern Transvaal Coalfield.

  1. RACORO continental boundary layer cloud investigations: 1. Case study development and ensemble large-scale forcings

    Science.gov (United States)

    Vogelmann, Andrew M.; Fridlind, Ann M.; Toto, Tami; Endo, Satoshi; Lin, Wuyin; Wang, Jian; Feng, Sha; Zhang, Yunyan; Turner, David D.; Liu, Yangang; Li, Zhijin; Xie, Shaocheng; Ackerman, Andrew S.; Zhang, Minghua; Khairoutdinov, Marat

    2015-06-01

    Observation-based modeling case studies of continental boundary layer clouds have been developed to study cloudy boundary layers, aerosol influences upon them, and their representation in cloud- and global-scale models. Three 60 h case study periods span the temporal evolution of cumulus, stratiform, and drizzling boundary layer cloud systems, representing mixed and transitional states rather than idealized or canonical cases. Based on in situ measurements from the Routine AAF (Atmospheric Radiation Measurement (ARM) Aerial Facility) CLOWD (Clouds with Low Optical Water Depth) Optical Radiative Observations (RACORO) field campaign and remote sensing observations, the cases are designed with a modular configuration to simplify use in large-eddy simulations (LES) and single-column models. Aircraft measurements of aerosol number size distribution are fit to lognormal functions for concise representation in models. Values of the aerosol hygroscopicity parameter, κ, are derived from observations to be 0.10, which are lower than the 0.3 typical over continents and suggestive of a large aerosol organic fraction. Ensemble large-scale forcing data sets are derived from the ARM variational analysis, European Centre for Medium-Range Weather Forecasts, and a multiscale data assimilation system. The forcings are assessed through comparison of measured bulk atmospheric and cloud properties to those computed in "trial" large-eddy simulations, where more efficient run times are enabled through modest reductions in grid resolution and domain size compared to the full-sized LES grid. Simulations capture many of the general features observed, but the state-of-the-art forcings were limited at representing details of cloud onset, and tight gradients and high-resolution transients of importance. Methods for improving the initial conditions and forcings are discussed. The cases developed are available to the general modeling community for studying continental boundary clouds.

  2. RACORO Continental Boundary Layer Cloud Investigations: 1. Case Study Development and Ensemble Large-Scale Forcings

    Science.gov (United States)

    Vogelmann, Andrew M.; Fridlind, Ann M.; Toto, Tami; Endo, Satoshi; Lin, Wuyin; Wang, Jian; Feng, Sha; Zhang, Yunyan; Turner, David D.; Liu, Yangang; hide

    2015-01-01

    Observation-based modeling case studies of continental boundary layer clouds have been developed to study cloudy boundary layers, aerosol influences upon them, and their representation in cloud- and global-scale models. Three 60 h case study periods span the temporal evolution of cumulus, stratiform, and drizzling boundary layer cloud systems, representing mixed and transitional states rather than idealized or canonical cases. Based on in situ measurements from the Routine AAF (Atmospheric Radiation Measurement (ARM) Aerial Facility) CLOWD (Clouds with Low Optical Water Depth) Optical Radiative Observations (RACORO) field campaign and remote sensing observations, the cases are designed with a modular configuration to simplify use in large-eddy simulations (LES) and single-column models. Aircraft measurements of aerosol number size distribution are fit to lognormal functions for concise representation in models. Values of the aerosol hygroscopicity parameter, kappa, are derived from observations to be approximately 0.10, which are lower than the 0.3 typical over continents and suggestive of a large aerosol organic fraction. Ensemble large-scale forcing data sets are derived from the ARM variational analysis, European Centre for Medium-Range Weather Forecasts, and a multiscale data assimilation system. The forcings are assessed through comparison of measured bulk atmospheric and cloud properties to those computed in "trial" large-eddy simulations, where more efficient run times are enabled through modest reductions in grid resolution and domain size compared to the full-sized LES grid. Simulations capture many of the general features observed, but the state-of-the-art forcings were limited at representing details of cloud onset, and tight gradients and high-resolution transients of importance. Methods for improving the initial conditions and forcings are discussed. The cases developed are available to the general modeling community for studying continental boundary

  3. Atomic-force microscopy: a powerful, multipurpose technique for the investigation of materials

    International Nuclear Information System (INIS)

    Cousty, J.

    2010-01-01

    An atomic-force microscope (AFM) comprises a probe (a tip) mounted at the free extremity of a spring of known stiffness, a control system, and a scanning system, which moves the probe across the sample's surface. The interaction between probe and surface (forces, or force gradient) is kept equal to a set value, by continuously adjusting the separation distance, via a feedback loop. An AFM image thus corresponds to a constant-interaction contour, obtained by moving the tip along the surface. This contour matches, as a rule, the topography of the sample. The image obtained is then the topography of the surface. The contribution made by AFM to materials science is illustrated in 4 examples. The first example concerns the first observations of irradiation damage in an electrical insulator material, thus one not readily observable by means of conventional electron microscopes. The second illustration relates to monitoring the emergence of defects due to plastic deformation observed in metals. The third example serves as an illustration of the capability afforded by AFM, of ensuring the acquisition of two types of information. Using an AFM fitted with a special module, the electrical resistivity of the passive layer that covers the surface of stainless steels was measured, concurrently with the sample's topography. The final illustration concerns the 3-dimensional self-organization of molecules at the interface between a solid and a liquid. (A.C.)

  4. Investigation of the transition from forced to natural convection in the research reactor Munich II

    International Nuclear Information System (INIS)

    Skreba, S.; Adamek, J.; Unger, H.

    1999-01-01

    The new research reactor Munich II (FRM-II), which is under construction at the Technical University Munich, Germany, makes use of a newly developed compact reactor core consisting of a single fuel element, which is assembled of two concentric pipes. Between the fuel element's inner and outer pipe 113 involutely bent fuel plates are placed rotationally symmetric, forming 113 cooling channels of a constant width of 2.2 mm. After a shut down of the reactor, battery supported cooling pumps are started by the reactor safety system in order to remove the decay heat by a downwards directed forced flow. Three hours after they have been started, the cooling pumps are shut down and so-called 'natural convection flaps' are opened by their own weight. Through a flow path, which is provided by the opening of the natural convection flaps, the decay heat is given off to the water in the reactor pool after the direction of the flow has changed and an upwards directed natural convection flow has developed. At the Department for Nuclear and New Energy Systems of the Ruhr-University Bochum, Germany, a test facility has been built in order to confirm the concept of the decay heat removal in the FRM-II, to acquire data of single and two phase natural convection flows and to detect the dry out in a narrow channel. The thermohydraulics of the FRM-II are simulated by an electrically heated test section, which represents one cooling channel of the fuel element. At first experiments have been performed, which simulated the transition from forced to natural convection in the core of the FRM-II, both at normal operation and at a complete loss of the decay heat removal pumps. In case of normal operation, the transition from forced to natural convection takes place single phased. If a complete loss of the active decay heat removal system occurs, the decay heat removal is ensured by a quasi-steady two phase flow. In a second test series minimum heat flux densities leading to pressure pulsations

  5. Investigating the Linear Dependence of Direct and Indirect Radiative Forcing on Emission of Carbonaceous Aerosols in a Global Climate Model

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yanju [Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, Urbana IL USA; Wang, Hailong [Atmospheric Sciences and Global Change Division, Pacific Northwest National Laboratory, Richland WA USA; Singh, Balwinder [Atmospheric Sciences and Global Change Division, Pacific Northwest National Laboratory, Richland WA USA; Ma, Po-Lun [Atmospheric Sciences and Global Change Division, Pacific Northwest National Laboratory, Richland WA USA; Rasch, Philip J. [Atmospheric Sciences and Global Change Division, Pacific Northwest National Laboratory, Richland WA USA; Bond, Tami C. [Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, Urbana IL USA

    2018-02-02

    The linearity of dependence of aerosol direct and indirect radiative forcing (DRF and IRF) on emissions is essential to answer the policy-relevant question on how the change in forcing would result from a change in emission. In this study, the forcing-to-emission relationship is investigated for black carbon (BC) and primary organic carbon (OC) emitted from North America and Asia. Direct and indirect radiative forcing of BC and OC are simulated with the Community Atmosphere Model (CAM5.1). Two diagnostics are introduced to aid in policy-relevant discussion: emission-normalized forcing (ENF) and linearity (R). DRF is linearly related to emission for both BC and OC from the two regions and emission-normalized DRF is similar, within 15%. IRF is linear to emissions for weaker sources and regions far from source (North American BC and OC), while for large emission sources and near source regions (Asian OC) the response of forcing to emission is sub-linear. In North America emission-normalized IRF (ENIRF) is 2-4 times higher than that in Asia. The difference among regions and species is primarily caused by failure of accumulation mode particles to become CCN, and then to activate into CDNC. Optimal aggregation area (30ºx 30º) has been used to communicate the regional variation of forcing-to-emission relationship. For IRF, only 15-40% of the Earth’s surface is significantly affected by the two emission regions, but the forcing in these regions comprises most of the global impact. Linearity of IRF occurs in about two-thirds of the significant regions except for Asian OC. ENF is an effective tool to estimate forcing changes due to reduction of surface emissions, as long as there is sufficient attention to the causes of nonlinearity in the simulations used to derive ENIRF (emission into polluted regions and emission elevation). The differences in ENIRF have important implications for policy decisions. Lower ENIRF in more polluted region like Asia means that reductions of

  6. Effects of fuel Lewis number on localised forced ignition of turbulent homogeneous mixtures: A numerical investigation

    Directory of Open Access Journals (Sweden)

    Dipal Patel

    2016-09-01

    Full Text Available The influences of fuel Lewis number LeF (ranging from 0.8 to 1.2 on localised forced ignition and early stages of combustion of stoichiometric and fuel-lean homogeneous mixtures have been analysed using simple chemistry three-dimensional compressible direct numerical simulations for different values of root-mean-square velocity fluctuation and the energy deposition characteristics (i.e. characteristic width and the duration of energy deposition by the ignitor. The localised forced ignition is modelled using a source term in the energy transport equation, which deposits energy in a Gaussian manner from the centre of the ignitor over a stipulated period of time. The fuel Lewis number LeF has been found to have significant influences on the extent of burning of stoichiometric and fuel-lean homogeneous mixtures. It has been shown that the width of ignition energy deposition and the duration over which the ignition energy is deposited have significant influences on the success of ignition and subsequent flame propagation. An increase in the width of ignition energy deposition and the duration of energy deposition for a given amount of ignition energy have been found to have detrimental effects on the ignition event, which may ultimately lead to misfire. For a given value of u' (LeF, the rate of heat transfer from the hot gas kernel increases with increasing LeF (u', which in turn leads to a reduction in the extent of overall burning for both stoichiometric and fuel-lean homogeneous mixtures but the detrimental effects of high values of u' on localised forced ignition are particularly prevalent for fuel-lean mixtures. Detailed physical explanations have been provided for the observed LeF,u' and energy deposition characteristics effects.

  7. Investigation of combined free and forced convection in a 2 x 6 rod bundle during controlled flow transients

    International Nuclear Information System (INIS)

    Bates, J.M.; Khan, E.U.

    1980-10-01

    An experimental study was performed to obtain local fluid velocity and temperature measurements in the mixed (combined free and forced) convection regime for specific flow coastdown transients. A brief investigation of steady-state flows for the purely free-convection regime was also completed. The study was performed using an electrically heated 2 x 6 rod bundle contained in a flow housing. In addition a transient data base was obtained for evaluating the COBRA-WC thermal-hydraulic computer program

  8. Design and construction of a heat stage for investigations of samples by atomic force microscopy above ambient temperatures

    DEFF Research Database (Denmark)

    Bækmark, Thomas Rosleff; Bjørnholm, Thomas; Mouritsen, Ole G.

    1997-01-01

    The construction from simple and cheap commercially available parts of a miniature heat stage for the direct heating of samples studied with a commercially available optical-lever-detection atomic force microscope is reported. We demonstrate that by using this heat stage, atomic resolution can...... be obtained on highly oriented pyrolytic graphite at 52 °C. The heat stage is of potential use for the investigation of biological material at physiological temperatures. ©1997 American Institute of Physics....

  9. The Flux-Anomaly-Forced Model Intercomparison Project (FAFMIP) Contribution to CMIP6: Investigation of Sea-Level and Ocean Climate Change in Response to CO2 Forcing

    Science.gov (United States)

    Gregory, Jonathan M.; Bouttes, Nathaelle; Griffies, Stephen M.; Haak, Helmuth; Hurlin, William J.; Jungclaus, Johann; Kelley, Maxwell; Lee, Warren G.; Marshall, John; Romanou, Anastasia; hide

    2016-01-01

    The Flux-Anomaly-Forced Model Intercomparison Project (FAFMIP) aims to investigate the spread in simulations of sea-level and ocean climate change in response to CO2 forcing by atmosphere-ocean general circulation models (AOGCMs). It is particularly motivated by the uncertainties in projections of ocean heat uptake, global-mean sealevel rise due to thermal expansion and the geographical patterns of sea-level change due to ocean density and circulation change. FAFMIP has three tier-1 experiments, in which prescribed surface flux perturbations of momentum, heat and freshwater respectively are applied to the ocean in separate AOGCM simulations. All other conditions are as in the pre-industrial control. The prescribed fields are typical of pattern and magnitude of changes in these fluxes projected by AOGCMs for doubled CO2 concentration. Five groups have tested the experimental design with existing AOGCMs. Their results show diversity in the pattern and magnitude of changes, with some common qualitative features. Heat and water flux perturbation cause the dipole in sea-level change in the North Atlantic, while momentum and heat flux perturbation cause the gradient across the Antarctic Circumpolar Current. The Atlantic meridional overturning circulation (AMOC) declines in response to the heat flux perturbation, and there is a strong positive feedback on this effect due to the consequent cooling of sea-surface temperature in the North Atlantic, which enhances the local heat input to the ocean. The momentum and water flux perturbations do not substantially affect the AMOC. Heat is taken up largely as a passive tracer in the Southern Ocean, which is the region of greatest heat input, while the weakening of the AMOC causes redistribution of heat towards lower latitudes. Future analysis of these and other phenomena with the wider range of CMIP6 FAFMIP AOGCMs will benefit from new diagnostics of temperature and salinity tendencies, which will enable investigation of the model

  10. Investigation of water entry impact forces on airborne-launched AUVs

    Directory of Open Access Journals (Sweden)

    Duo Qi

    2016-01-01

    Full Text Available Airborne-launched AUVs withstand great fluid impact force at the early stage when entering the water, which may cause damage to their structure and inner components in severe cases. Due to their large volume and mass, the major challenge involved in conducting experiments to measure the water entry impacts on real-life AUVs is the high demand for the experimental devices, finding a suitable site, and the cost of the experiments. Using a gas gun as launching device, water entry experiments using a full-size AUV model are conducted under various conditions. The axial and radial force changes that occur during the water entry process are obtained, and some accompanied phenomena such as cavitation and turnover under different water entry conditions are observed. Computational fluid dynamics (CFD is used to simulate the water entry process of airborne-launched AUVs. The simulation results fit well with the experimental data, the latter of which show that both the water entry velocity and entry angle have a great influence on the impact load during the water entry process. These data can provide valuable reference information for AUV structure design and launch condition selection.

  11. Interaction of cement model systems with superplasticizers investigated by atomic force microscopy, zeta potential, and adsorption measurements.

    Science.gov (United States)

    Ferrari, Lucia; Kaufmann, Josef; Winnefeld, Frank; Plank, Johann

    2010-07-01

    Polyelectrolyte-based dispersants are commonly used in a wide range of industrial applications to provide specific workability to colloidal suspensions. Their working mechanism is based on adsorption onto the surfaces of the suspended particles. The adsorbed polymer layer can exercise an electrostatic and/or a steric effect which is responsible for achieving dispersion. This study is focused on the dispersion forces induced by polycarboxylate ether-based superplasticizers (PCEs) commonly used in concrete. They are investigated by atomic force microscopy (AFM) applying standard silicon nitride tips exposed to solutions with different ionic compositions in a wet cell. Adsorption isotherms and zeta potential analysis were performed to characterize polymer displacement in the AFM system on nonreactive model substrates (quartz, mica, calcite, and magnesium oxide) in order to avoid the complexity of cement hydration products. The results show that PCE is strongly adsorbed by positively charged materials. This fact reveals that, being silicon nitride naturally positively charged, in most cases the superplasticizer adsorbs preferably on the silicon nitride tip than on the AFM substrate. However, the force-distance curves displayed repulsive interactions between tip and substrates even when polymer was poorly adsorbed on both. These observations allow us to conclude that the dispersion due to PCE strongly depends on the particle charge. It differs between colloids adsorbing and not adsorbing PCE, and leads to different forces acting between the particles. Copyright 2010 Elsevier Inc. All rights reserved.

  12. Investigation into the Effect of Acoustic Radiation Force and Acoustic Streaming on Particle Patterning in Acoustic Standing Wave Fields

    Directory of Open Access Journals (Sweden)

    Shilei Liu

    2017-07-01

    Full Text Available Acoustic standing waves have been widely used in trapping, patterning, and manipulating particles, whereas one barrier remains: the lack of understanding of force conditions on particles which mainly include acoustic radiation force (ARF and acoustic streaming (AS. In this paper, force conditions on micrometer size polystyrene microspheres in acoustic standing wave fields were investigated. The COMSOL® Mutiphysics particle tracing module was used to numerically simulate force conditions on various particles as a function of time. The velocity of particle movement was experimentally measured using particle imaging velocimetry (PIV. Through experimental and numerical simulation, the functions of ARF and AS in trapping and patterning were analyzed. It is shown that ARF is dominant in trapping and patterning large particles while the impact of AS increases rapidly with decreasing particle size. The combination of using both ARF and AS for medium size particles can obtain different patterns with only using ARF. Findings of the present study will aid the design of acoustic-driven microfluidic devices to increase the diversity of particle patterning.

  13. Investigation into the Effect of Acoustic Radiation Force and Acoustic Streaming on Particle Patterning in Acoustic Standing Wave Fields

    Science.gov (United States)

    Yang, Yanye; Ni, Zhengyang; Guo, Xiasheng; Luo, Linjiao; Tu, Juan; Zhang, Dong

    2017-01-01

    Acoustic standing waves have been widely used in trapping, patterning, and manipulating particles, whereas one barrier remains: the lack of understanding of force conditions on particles which mainly include acoustic radiation force (ARF) and acoustic streaming (AS). In this paper, force conditions on micrometer size polystyrene microspheres in acoustic standing wave fields were investigated. The COMSOL® Mutiphysics particle tracing module was used to numerically simulate force conditions on various particles as a function of time. The velocity of particle movement was experimentally measured using particle imaging velocimetry (PIV). Through experimental and numerical simulation, the functions of ARF and AS in trapping and patterning were analyzed. It is shown that ARF is dominant in trapping and patterning large particles while the impact of AS increases rapidly with decreasing particle size. The combination of using both ARF and AS for medium size particles can obtain different patterns with only using ARF. Findings of the present study will aid the design of acoustic-driven microfluidic devices to increase the diversity of particle patterning. PMID:28753955

  14. Atomic force microscopy and nanoindentation investigation of polydimethylsiloxane elastomeric substrate compliancy for various sputtered thin film morphologies.

    Science.gov (United States)

    Maji, Debashis; Das, Soumen

    2018-03-01

    Crack free electrically continuous metal thin films over soft elastomeric substrates play an integral part in realization of modern day flexible bioelectronics and biosensors. Under nonoptimized deposition conditions, delamination, and/or cracking of the top film as well as the underlying soft substrate hinders optimal performance of these devices. Hence it is very important to understand and control not only the various deposition factors like power, time, or deposition pressure but also investigate the various interfacial physics playing a critical role in assuring thin film adhesion and substrate compliancy. In the present study, various nanomechanical information of the underlying substrate, namely, crack profile, average roughness, Young's modulus, and adhesion force were studied for uncracked and cracked polydimethylsiloxane (PDMS) surfaces along with pristine and conventional plasma treated PDMS samples as control. Quantification of the above parameters were done using three-dimensional surface profiler, scanning electron microscopy, nanoindentation, and atomic force microscopy techniques to elucidate the modulus range, average roughness, and adhesion force. Comparative analysis with control revealed remarkable similarity between increased modulus values, increased surface roughness, and reduced adhesion force accounting for reduced substrate compliancy and resulting in film cracking or buckling which are critical for development of various bioflexible devices. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 725-737, 2018. © 2017 Wiley Periodicals, Inc.

  15. Atomic force microscopy investigation of growth process of organic TCNQ aggregates on SiO2 and mica substrates

    Science.gov (United States)

    Huan, Qing; Hu, Hao; Pan, Li-Da; Xiao, Jiang; Du, Shi-Xuan; Gao, Hong-Jun

    2010-08-01

    Deposition patterns of tetracyanoquinodimethane (TCNQ) molecules on different surfaces are investigated by atomic force microscopy. A homemade physical vapour deposition system allows the better control of molecule deposition. Taking advantage of this system, we investigate TCNQ thin film growth on both SiO2 and mica surfaces. It is found that dense island patterns form at a high deposition rate, and a unique seahorse-like pattern forms at a low deposition rate. Growth patterns on different substrates suggest that the fractal pattern formation is dominated by molecule-molecule interaction. Finally, a phenomenal “two-branch" model is proposed to simulate the growth process of the seahorse pattern.

  16. Atomic force microscopy investigation of growth process of organic TCNQ aggregates on SiO2 and mica substrates

    International Nuclear Information System (INIS)

    Qing, Huan; Hao, Hu; Li-Da, Pan; Jiang, Xiao; Shi-Xuan, Du; Hong-Jun, Gao

    2010-01-01

    Deposition patterns of tetracyanoquinodimethane (TCNQ) molecules on different surfaces are investigated by atomic force microscopy. A homemade physical vapour deposition system allows the better control of molecule deposition. Taking advantage of this system, we investigate TCNQ thin film growth on both SiO 2 and mica surfaces. It is found that dense island patterns form at a high deposition rate, and a unique seahorse-like pattern forms at a low deposition rate. Growth patterns on different substrates suggest that the fractal pattern formation is dominated by molecule–molecule interaction. Finally, a phenomenal “two-branch” model is proposed to simulate the growth process of the seahorse pattern. (general)

  17. Experimental investigation of a forced response condition in a multistage compressor

    Science.gov (United States)

    Murray, William Louis, III

    The objective of this research is twofold. Firstly, the design, development, and construction of a test facility for a Honeywell APU-style centrifugal compressor was implemented, as well as the design and construction of an inlet flow experiment. Secondly, the aeromechanical response of an embedded stage in the Purdue 3-Stage axial research compressor was analyzed through a suite of different measurement techniques in the fulfillment of the end of the GUIde IV Consortium contract. The purpose of the first phase of Honeywell work was to comprehensively measure the flow field of an APU-style centrifugal compressor inlet through the use of Laser Doppler Velocimetry (LDV). A portion of a Honeywell supplied inlet was modified to provide optical access to the elbow, and a gas ejector system was designed and constructed to provide the same suction to the inlet that it would see during operation with the compressor. A performance and health monitoring electronics system was designed and purchased to support the testing of the Honeywell inlet ejector system and eventually it will be used for testing with a centrifugal compressor. Additionally, a secondary air and oil system has been designed and is currently being constructed in the test cell in preparation for the arrival of the Honeywell compressor this summer. An embedded rotor stage in the Purdue 3-stage compressor, with a Campbell diagram crossing of the 1T vibratory mode was analyzed with a suite of measurement systems. In addition to steady state compressor performance measurements, other types of measurements were used to characterize the aerodynamic forcing function for this forced response condition including: NSMS, high-frequency pressure transducers mounted in the casing and in a downstream stator, and cross-film thermal anemometry. Rotor geometry was measured by Aerodyne using an in-situ laser scanning technique. Vibrometry testing was performed at WPAFB to characterize safe operating speeds for stator

  18. Atomic force microscopy investigation of Turnip Yellow Mosaic Virus capsid disruption and RNA extrusion

    International Nuclear Information System (INIS)

    Kuznetsov, Yu. G.; McPherson, Alexander

    2006-01-01

    Turnip Yellow Mosaic Virus (TYMV) was subjected to a variety of procedures which disrupted the protein capsids and produced exposure of the ssRNA genome. The results of the treatments were visualized by atomic force microscopy (AFM). Both in situ and ex situ freeze-thawing produced RNA emission, though at low efficiency. The RNA lost from such particles was evident, in some cases in the process of exiting the virions. More severe disruption of TYMV and extrusion of intact RNA onto the substrate were produced by drying the virus and rehydrating with neutral buffer. Similar products were also obtained by heating TYMV to 70-75 deg. C and by exposure to alkaline pH. Experiments showed the nucleic acid to have an elaborate secondary structure distributed linearly along its length

  19. Investigation of surface potentials in reduced graphene oxide flake by Kelvin probe force microscopy

    Science.gov (United States)

    Negishi, Ryota; Takashima, Kai; Kobayashi, Yoshihiro

    2018-06-01

    The surface potential (SP) of reduced graphene oxide (rGO) flakes prepared by thermal treatments of GO under several conditions was analyzed by Kelvin probe force microscopy. The low-crystalline rGO flakes in which a significant amount of oxygen functional groups and structural defects remain have a much lower SP than mechanically exfoliated graphene free from oxygen and defects. On the other hand, the highly crystalline rGO flake after a thermal treatment for the efficient removal of oxygen functional groups and healing of structural defects except for domain boundary shows SP equivalent to that of the mechanically exfoliated graphene. These results indicate that the work function of rGO is sensitively modulated by oxygen functional groups and structural defects remaining after the thermal reduction process, but is not affected significantly by the domain boundary remaining after the healing of structural defects through the thermal treatment at high temperature.

  20. Ex situ investigation of the step bunching on crystal surfaces by atomic force microscopy

    Science.gov (United States)

    Krasinski, Mariusz J.

    1997-07-01

    We are describing ex situ observation of step bunching on the surfaces of solution grown potassium dihydrogen phosphate (KDP) and sodium chlorate monocrystals. The measurements have been done with the use of atomic force microscope. The use of this equipment allowed us to see directly the structure of macrosteps. Observation confirmed the existence of step pinning which is one of the proposed mechanisms of step bunching. Despite the very high resolution of AFM it was not possible to determine the nature of pinning point. The monatomic steps on KDP and sodium chlorate crystal surfaces are mainly one unit cell high what seems to be the result of the steps pairing. The origin of observed step pattern is discussed in frames of existing theories.

  1. Atomic Force Microscopy Investigation of Morphological and Nanomechanical Properties of Pseudomonas aeruginosa Cells

    DEFF Research Database (Denmark)

    Mortensen, Ninell Pollas

    2008-01-01

    changes in the fraction of individual bacteria and bacteria undergoing proliferation, and decrease of cell length of mother and daughter cells. The results indicated that colistin arrested the bacterial growth just after septum formation. Furthermore did the morphology change from a smooth bacterial......Atomic Force Microscopy (AFM) is unique in the aspect of studying living biological sample under physiological conditions. AFM was invented in 1986 by Binnig and Gerber and began in the early 1990’s to be implemented in life science. AFM can give a detailed three dimensional image of an intact cell......, but also be used to examine the nanomechanical properties on single cell level. These qualities make AFM a powerful tool in biology and can be used to examine both morphological and nanomechanical response to various liquids environments, such as osmotic pressure, but also the effects of e.g. antibiotic...

  2. Humidity-dependent bacterial cells functional morphometry investigations using atomic force microscope.

    Science.gov (United States)

    Nikiyan, Hike; Vasilchenko, Alexey; Deryabin, Dmitry

    2010-01-01

    The effect of a relative humidity (RH) in a range of 93-65% on morphological and elastic properties of Bacillus cereus and Escherichia coli cells was evaluated using atomic force microscopy. It is shown that gradual dehumidification of bacteria environment has no significant effect on cell dimensional features and considerably decreases them only at 65% RH. The increasing of the bacteria cell wall roughness and elasticity occurs at the same time. Observed changes indicate that morphological properties of B. cereus are rather stable in wide range of relative humidity, whereas E. coli are more sensitive to drying, significantly increasing roughness and stiffness parameters at RH

  3. Humidity-Dependent Bacterial Cells Functional Morphometry Investigations Using Atomic Force Microscope

    Directory of Open Access Journals (Sweden)

    Hike Nikiyan

    2010-01-01

    Full Text Available The effect of a relative humidity (RH in a range of 93–65% on morphological and elastic properties of Bacillus cereus and Escherichia coli cells was evaluated using atomic force microscopy. It is shown that gradual dehumidification of bacteria environment has no significant effect on cell dimensional features and considerably decreases them only at 65% RH. The increasing of the bacteria cell wall roughness and elasticity occurs at the same time. Observed changes indicate that morphological properties of B. cereus are rather stable in wide range of relative humidity, whereas E. coli are more sensitive to drying, significantly increasing roughness and stiffness parameters at RH ≤ 84% RH. It is discussed the dependence of the response features on differences in cell wall structure of gram-positive and gram-negative bacterial cells.

  4. The architecture of neutrophil extracellular traps investigated by atomic force microscopy

    Science.gov (United States)

    Pires, Ricardo H.; Felix, Stephan B.; Delcea, Mihaela

    2016-07-01

    Neutrophils are immune cells that engage in a suicidal pathway leading to the release of partially decondensed chromatin, or neutrophil extracellular traps (NETs). NETs behave as a double edged sword; they can bind to pathogens thereby ensnaring them and limiting their spread during infection; however, they may bind to host circulating materials and trigger thrombotic events, and are associated with autoimmune disorders. Despite the fundamental role of NETs as part of an immune system response, there is currently a very poor understanding of how their nanoscale properties are reflected in their macroscopic impact. In this work, using a combination of fluorescence and atomic force microscopy, we show that NETs appear as a branching filament network that results in a substantially organized porous structure with openings with 0.03 +/- 0.04 μm2 on average and thus in the size range of small pathogens. Topological profiles typically up to 3 +/- 1 nm in height are compatible with a ``beads on a string'' model of nucleosome chromatin. Typical branch lengths of 153 +/- 103 nm appearing as rigid rods and height profiles of naked DNA in NETs of 1.2 +/- 0.5 nm are indicative of extensive DNA supercoiling throughout NETs. The presence of DNA duplexes could also be inferred from force spectroscopy and the occurrence of force plateaus that ranged from ~65 pN to 300 pN. Proteolytic digestion of NETs resulted in widespread disassembly of the network structure and considerable loss of mechanical properties. Our results suggest that the underlying structure of NETs is considerably organized and that part of its protein content plays an important role in maintaining its mesh architecture. We anticipate that NETs may work as microscopic mechanical sieves with elastic properties that stem from their DNA-protein composition, which is able to segregate particles also as a result of their size. Such a behavior may explain their participation in capturing pathogens and their association

  5. Investigation, sensitivity analysis, and multi-objective optimization of effective parameters on temperature and force in robotic drilling cortical bone.

    Science.gov (United States)

    Tahmasbi, Vahid; Ghoreishi, Majid; Zolfaghari, Mojtaba

    2017-11-01

    The bone drilling process is very prominent in orthopedic surgeries and in the repair of bone fractures. It is also very common in dentistry and bone sampling operations. Due to the complexity of bone and the sensitivity of the process, bone drilling is one of the most important and sensitive processes in biomedical engineering. Orthopedic surgeries can be improved using robotic systems and mechatronic tools. The most crucial problem during drilling is an unwanted increase in process temperature (higher than 47 °C), which causes thermal osteonecrosis or cell death and local burning of the bone tissue. Moreover, imposing higher forces to the bone may lead to breaking or cracking and consequently cause serious damage. In this study, a mathematical second-order linear regression model as a function of tool drilling speed, feed rate, tool diameter, and their effective interactions is introduced to predict temperature and force during the bone drilling process. This model can determine the maximum speed of surgery that remains within an acceptable temperature range. Moreover, for the first time, using designed experiments, the bone drilling process was modeled, and the drilling speed, feed rate, and tool diameter were optimized. Then, using response surface methodology and applying a multi-objective optimization, drilling force was minimized to sustain an acceptable temperature range without damaging the bone or the surrounding tissue. In addition, for the first time, Sobol statistical sensitivity analysis is used to ascertain the effect of process input parameters on process temperature and force. The results show that among all effective input parameters, tool rotational speed, feed rate, and tool diameter have the highest influence on process temperature and force, respectively. The behavior of each output parameters with variation in each input parameter is further investigated. Finally, a multi-objective optimization has been performed considering all the

  6. Experimental investigation and modelling of surface roughness and resultant cutting force in hard turning of AISI H13 Steel

    Science.gov (United States)

    Boy, M.; Yaşar, N.; Çiftçi, İ.

    2016-11-01

    In recent years, turning of hardened steels has replaced grinding for finishing operations. This process is compared to grinding operations; hard turning has higher material removal rates, the possibility of greater process flexibility, lower equipment costs, and shorter setup time. CBN or ceramic cutting tools are widely used hard part machining. For successful application of hard turning, selection of suitable cutting parameters for a given cutting tool is an important step. For this purpose, an experimental investigation was conducted to determine the effects of cutting tool edge geometry, feed rate and cutting speed on surface roughness and resultant cutting force in hard turning of AISI H13 steel with ceramic cutting tools. Machining experiments were conducted in a CNC lathe based on Taguchi experimental design (L16) in different levels of cutting parameters. In the experiments, a Kistler 9257 B, three cutting force components (Fc, Ff and Fr) piezoelectric dynamometer was used to measure cutting forces. Surface roughness measurements were performed by using a Mahrsurf PS1 device. For statistical analysis, analysis of variance has been performed and mathematical model have been developed for surface roughness and resultant cutting forces. The analysis of variance results showed that the cutting edge geometry, cutting speed and feed rate were the most significant factors on resultant cutting force while the cutting edge geometry and feed rate were the most significant factor for the surface roughness. The regression analysis was applied to predict the outcomes of the experiment. The predicted values and measured values were very close to each other. Afterwards a confirmation tests were performed to make a comparison between the predicted results and the measured results. According to the confirmation test results, measured values are within the 95% confidence interval.

  7. Investigation of flow mechanism of a robotic fish swimming by using flow visualization synchronized with hydrodynamic force measurement

    Science.gov (United States)

    Tan, Guang-Kun; Shen, Gong-Xin; Huang, Shuo-Qiao; Su, Wen-Han; Ke, Yu

    When swimming in water by flapping its tail, a fish can overcome the drag from uniform flow and propel its body. The involved flow mechanism concerns 3-D and unsteady effects. This paper presents the investigation of the flow mechanism on the basis of a 3-D robotic fish model which has the typical geometry of body and tail with periodic flapping 2-freedom kinematical motion testing in the case of St = 0.78, Re = 6,600 and phase delay mode (φ = - 75°), in which may have a greater or maximum propulsion (without consideration of the optimal efficiency). Using a special technique of dye visualization which can clearly show vortex sheet and vortices in detail and using the inner 3-component force balance and cable supporting system with the phase-lock technique, the 3-D flow structure visualized in the wake of fish and the hydrodynamic force measurement were synchronized and obtained. Under the mentioned flapping parameters, we found the key flow structure and its evolution, a pair of complex 3-D chain-shape vortex (S-H vortex-rings, S1 - H1 and S2 - H2, and their legs L1 and L2) flow structures, which attach the leading edge and the trailing edge, then shed, move downstream and outwards and distribute two antisymmetric staggering arrays along with the wake of the fish model in different phase stages during the flapping period. It is different with in the case of St = 0.25-0.35. Its typical flow structure and evolution are described and the results prove that they are different from the viewpoints based on the investigation of 2-D cases. For precision of the dynamic force measurement, in this paper it was provided with the method and techniques by subtracting the inertial forces and the forces induced by buoyancy and gravity effect in water, etc. from original data measured. The evolution of the synchronized measuring forces directly matching with the flow structure was also described in this paper.

  8. [Environmental investigation of ground water contamination at Wright-Patterson Air Force Base, Ohio

    International Nuclear Information System (INIS)

    1992-04-01

    This Removal Action System Design has been prepared as a Phase I Volume for the implementation of the Phase II removal action at Wright-Patterson Air Force Base (WPAFB) near Dayton, Ohio. The objective of the removal action is to prevent, to the extent practicable, the migration of ground water contaminated with chlorinated volatile organic compounds (VOCS) across the southwest boundary of Area C. The Phase 1, Volume 9 Removal Action System Design compiles the design documents prepared for the Phase II Removal Action. These documents, which are presented in Appendices to Volume 9, include: Process Design, which presents the 30 percent design for the ground water treatment system (GWTS); Design Packages 1 and 2 for Earthwork and Road Construction, and the Discharge Pipeline, respectively; no drawings are included in the appendix; Design Package 3 for installation of the Ground Water Extraction Well(s); Design Package 4 for installation of the Monitoring Well Instrumentation; and Design Package 5 for installation of the Ground Water Treatment System; this Design Package is incorporated by reference because of its size

  9. Localization of cesium on montmorillonite surface investigated by frequency modulation atomic force microscopy

    Science.gov (United States)

    Araki, Yuki; Satoh, Hisao; Okumura, Masahiko; Onishi, Hiroshi

    2017-11-01

    Cation exchange of clay mineral is typically analyzed without microscopic study of the clay surfaces. In order to reveal the distribution of exchangeable cations at the clay surface, we performed in situ atomic-scale observations of the surface changes in Na-rich montmorillonite due to exchange with Cs cations using frequency modulation atomic force microscopy (FM-AFM). Lines of protrusion were observed on the surface in aqueous CsCl solution. The amount of Cs of the montmorillonite particles analyzed by energy dispersive X-ray spectrometry was consistent with the ratio of the number of linear protrusions to all protrusions in the FM-AFM images. The results showed that the protrusions represent adsorbed Cs cations. The images indicated that Cs cations at the surface were immobile, and their occupancy remained constant at 10% of the cation sites at the surface with different immersion times in the CsCl solution. This suggests that the mobility and the number of Cs cations at the surface are controlled by the permanent charge of montmorillonite; however, the Cs distribution at the surface is independent of the charge distribution of the inner silicate layer. Our atomic-scale observations demonstrate that surface cations are distributed in different ways in montmorillonite and mica.

  10. Impedance Spectroscopic Investigation of Proton Conductivity in Nafion Using Transient Electrochemical Atomic Force Microscopy (AFM

    Directory of Open Access Journals (Sweden)

    Emil Roduner

    2012-06-01

    Full Text Available Spatially resolved impedance spectroscopy of a Nafion polyelectrolyte membrane is performed employing a conductive and Pt-coated tip of an atomic force microscope as a point-like contact and electrode. The experiment is conducted by perturbing the system by a rectangular voltage step and measuring the incurred current, followed by Fourier transformation and plotting the impedance against the frequency in a conventional Bode diagram. To test the potential and limitations of this novel method, we present a feasibility study using an identical hydrogen atmosphere at a well-defined relative humidity on both sides of the membrane. It is demonstrated that good quality impedance spectra are obtained in a frequency range of 0.2–1,000 Hz. The extracted polarization curves exhibit a maximum current which cannot be explained by typical diffusion effects. Simulation based on equivalent circuits requires a Nernst element for restricted diffusion in the membrane which suggests that this effect is based on the potential dependence of the electrolyte resistance in the high overpotential region.

  11. MDM2-MDM4 molecular interaction investigated by atomic force spectroscopy and surface plasmon resonance.

    Science.gov (United States)

    Moscetti, Ilaria; Teveroni, Emanuela; Moretti, Fabiola; Bizzarri, Anna Rita; Cannistraro, Salvatore

    Murine double minute 2 (MDM2) and 4 (MDM4) are known as the main negative regulators of p53, a tumor suppressor. They are able to form heterodimers that are much more effective in the downregulation of p53. Therefore, the MDM2-MDM4 complex could be a target for promising therapeutic restoration of p53 function. To this aim, a deeper understanding of the molecular mechanisms underlining the heterodimerization is needed. The kinetic and thermodynamic characterization of the MDM2-MDM4 complex was performed with two complementary approaches: atomic force spectroscopy and surface plasmon resonance. Both techniques revealed an equilibrium dissociation constant (KD ) in the micromolar range for the MDM2-MDM4 heterodimer, similar to related complexes involved in the p53 network. Furthermore, the MDM2-MDM4 complex is characterized by a relatively high free energy, through a single energy barrier, and by a lifetime in the order of tens of seconds. New insights into the MDM2-MDM4 interaction could be highly important for developing innovative anticancer drugs focused on p53 reactivation.

  12. The Flux-Anomaly-Forced Model Intercomparison Project (FAFMIP contribution to CMIP6: investigation of sea-level and ocean climate change in response to CO2 forcing

    Directory of Open Access Journals (Sweden)

    J. M. Gregory

    2016-11-01

    Full Text Available The Flux-Anomaly-Forced Model Intercomparison Project (FAFMIP aims to investigate the spread in simulations of sea-level and ocean climate change in response to CO2 forcing by atmosphere–ocean general circulation models (AOGCMs. It is particularly motivated by the uncertainties in projections of ocean heat uptake, global-mean sea-level rise due to thermal expansion and the geographical patterns of sea-level change due to ocean density and circulation change. FAFMIP has three tier-1 experiments, in which prescribed surface flux perturbations of momentum, heat and freshwater respectively are applied to the ocean in separate AOGCM simulations. All other conditions are as in the pre-industrial control. The prescribed fields are typical of pattern and magnitude of changes in these fluxes projected by AOGCMs for doubled CO2 concentration. Five groups have tested the experimental design with existing AOGCMs. Their results show diversity in the pattern and magnitude of changes, with some common qualitative features. Heat and water flux perturbation cause the dipole in sea-level change in the North Atlantic, while momentum and heat flux perturbation cause the gradient across the Antarctic Circumpolar Current. The Atlantic meridional overturning circulation (AMOC declines in response to the heat flux perturbation, and there is a strong positive feedback on this effect due to the consequent cooling of sea-surface temperature in the North Atlantic, which enhances the local heat input to the ocean. The momentum and water flux perturbations do not substantially affect the AMOC. Heat is taken up largely as a passive tracer in the Southern Ocean, which is the region of greatest heat input, while the weakening of the AMOC causes redistribution of heat towards lower latitudes. Future analysis of these and other phenomena with the wider range of CMIP6 FAFMIP AOGCMs will benefit from new diagnostics of temperature and salinity tendencies, which will enable

  13. Thermal investigation of lithium-ion battery module with different cell arrangement structures and forced air-cooling strategies

    International Nuclear Information System (INIS)

    Wang, Tao; Tseng, K.J.; Zhao, Jiyun; Wei, Zhongbao

    2014-01-01

    Highlights: • Three-dimensional CFD model with forced air cooling are developed for battery modules. • Impact of different air cooling strategies on module thermal characteristics are investigated. • Impact of different model structures on module thermal responses are investigated. • Effect of inter-cell spacing on cell thermal characteristics are also studied. • The optimal battery module structure and air cooling strategy is recommended. - Abstract: Thermal management needs to be carefully considered in the lithium-ion battery module design to guarantee the temperature of batteries in operation within a narrow optimal range. This article firstly explores the thermal performance of battery module under different cell arrangement structures, which includes: 1 × 24, 3 × 8 and 5 × 5 arrays rectangular arrangement, 19 cells hexagonal arrangement and 28 cells circular arrangement. In addition, air-cooling strategies are also investigated by installing the fans in the different locations of the battery module to improve the temperature uniformity. Factors that influence the cooling capability of forced air cooling are discussed based on the simulations. The three-dimensional computational fluid dynamics (CFD) method and lumped model of single cell have been applied in the simulation. The temperature distributions of batteries are quantitatively described based on different module patterns, fan locations as well as inter-cell distance, and the conclusions are arrived as follows: when the fan locates on top of the module, the best cooling performance is achieved; the most desired structure with forced air cooling is cubic arrangement concerning the cooling effect and cost, while hexagonal structure is optimal when focus on the space utilization of battery module. Besides, the optimized inter-cell distance in battery module structure has been recommended

  14. Investigation of the Interaction between Patulin and Human Serum Albumin by a Spectroscopic Method, Atomic Force Microscopy, and Molecular Modeling

    Directory of Open Access Journals (Sweden)

    Li Yuqin

    2014-01-01

    Full Text Available The interaction of patulin with human serum albumin (HSA was studied in vitro under normal physiological conditions. The study was performed using fluorescence, ultraviolet-visible spectroscopy (UV-Vis, circular dichroism (CD, atomic force microscopy (AFM, and molecular modeling techniques. The quenching mechanism was investigated using the association constants, the number of binding sites, and basic thermodynamic parameters. A dynamic quenching mechanism occurred between HSA and patulin, and the binding constants (K were 2.60 × 104, 4.59 × 104, and 7.01 × 104 M−1 at 288, 300, and 310 K, respectively. Based on fluorescence resonance energy transfer, the distance between the HSA and patulin was determined to be 2.847 nm. The ΔG0, ΔH0, and ΔS0 values across various temperatures indicated that hydrophobic interaction was the predominant binding force. The UV-Vis and CD results confirmed that the secondary structure of HSA was altered in the presence of patulin. The AFM results revealed that the individual HSA molecule dimensions were larger after interaction with patulin. In addition, molecular modeling showed that the patulin-HSA complex was stabilized by hydrophobic and hydrogen bond forces. The study results suggested that a weak intermolecular interaction occurred between patulin and HSA. Overall, the results are potentially useful for elucidating the toxigenicity of patulin when it is combined with the biomolecular function effect, transmembrane transport, toxicological, testing and other experiments.

  15. High-resolution noncontact AFM and Kelvin probe force microscopy investigations of self-assembled photovoltaic donor–acceptor dyads

    Directory of Open Access Journals (Sweden)

    Benjamin Grévin

    2016-06-01

    Full Text Available Self-assembled donor–acceptor dyads are used as model nanostructured heterojunctions for local investigations by noncontact atomic force microscopy (nc-AFM and Kelvin probe force microscopy (KPFM. With the aim to probe the photo-induced charge carrier generation, thin films deposited on transparent indium tin oxide substrates are investigated in dark conditions and upon illumination. The topographic and contact potential difference (CPD images taken under dark conditions are analysed in view of the results of complementary transmission electron microscopy (TEM experiments. After in situ annealing, it is shown that the dyads with longer donor blocks essentially lead to standing acceptor–donor lamellae, where the acceptor and donor groups are π-stacked in an edge-on configuration. The existence of strong CPD and surface photo-voltage (SPV contrasts shows that structural variations occur within the bulk of the edge-on stacks. SPV images with a very high lateral resolution are achieved, which allows for the resolution of local photo-charging contrasts at the scale of single edge-on lamella. This work paves the way for local investigations of the optoelectronic properties of donor–acceptor supramolecular architectures down to the elementary building block level.

  16. Investigation of the influence of vertical force on the contact between truck tyre and road using finite element analyses

    Science.gov (United States)

    Moisescu, Alexandra-Raluca; Anghelache, Gabriel

    2017-10-01

    In the modern context of automobile integration with the emerging technologies of the interconnected society, the interaction between tyre and road is an element of major importance for automobile safety systems such as the intelligent tyres, as well as for passenger comfort, fuel economy, environmental protection, infrastructure and vehicle durability. The tyre-road contact generates the distribution of forces exerted on each unit area in the contact patch, therefore the distribution of contact stresses on three orthogonal directions. The numerical investigation of stresses distribution in the contact patch requires the development of finite element models capable of accurately describing the interaction between tyre and rolling surface. The complex finite element model developed for the 11R22.5 truck tyre has been used for investigating the influence of vertical force on the distributions of contact stresses. In addition to these contributions, the paper presents aspects related to the simulation of truck tyre radial stiffness. The influence of tyre rolling has not been taken into consideration, as the purpose of the current research is the investigation of tyre-road contact in stationary conditions.

  17. Microscopic investigation of InGaN/GaN heterostructure laser diode degradation using Kelvin probe force microscopy

    International Nuclear Information System (INIS)

    Lochthofen, A; Mertin, W; Bacher, G; Furitsch, M; Bruederl, G; Strauss, U; Haerle, V

    2008-01-01

    We report on Kelvin probe force microscopy (KPFM) measurements on fresh and artificially aged InGaN/GaN laser test structures. In the case of an unbiased laser diode, a comparison of the surface potential between a fresh and a stressed laser diode shows a pronounced modification of the laser facet due to the aging process. Performing KPFM measurements under forward bias, a correlation between the macroscopic I-V characteristics and the microscopic voltage drop across the heterostructure layer sequence is found. This clearly demonstrates the potential of KPFM for investigating InGaN/GaN laser diode degradation

  18. A numerical investigation of flow around octopus-like arms: near-wake vortex patterns and force development.

    Science.gov (United States)

    Kazakidi, A; Vavourakis, V; Tsakiris, D P; Ekaterinaris, J A

    2015-01-01

    The fluid dynamics of cephalopods has so far received little attention in the literature, due to their complexity in structure and locomotion. The flow around octopuses, in particular, can be complicated due to their agile and dexterous arms, which frequently display some of the most diverse mechanisms of motion. The study of this flow amounts to a specific instance of the hydrodynamics problem for rough tapered cylinder geometries. The outstanding manipulative and locomotor skills of octopuses could inspire the development of advanced robotic arms, able to operate in fluid environments. Our primary aim was to study the hydrodynamic characteristics of such bio-inspired robotic models and to derive the hydrodynamic force coefficients as a concise description of the vortical flow effects. Utilizing computational fluid dynamic methods, the coefficients were computed on realistic morphologies of octopus-like arm models undergoing prescribed solid-body movements; such motions occur in nature for short durations in time, e.g. during reaching movements and exploratory behaviors. Numerical simulations were performed on translating, impulsively rotating, and maneuvering arms, around which the flow field structures were investigated. The results reveal in detail the generation of complex vortical flow structures around the moving arms. Hydrodynamic forces acting on a translating arm depend on the angle of incidence; forces generated during impulsive rotations of the arms are independent of their exact morphology and the angle of rotation; periodic motions based on a slow recovery and a fast power stroke are able to produce considerable propulsive thrust while harmonic motions are not. Parts of these results have been employed in bio-inspired models of underwater robotic mechanisms. This investigation may further assist elucidating the hydrodynamics underlying aspects of octopus locomotion and exploratory behaviors.

  19. New Investigator and Trainee Task Force Survey on the Recruitment and Retention of Headache Specialists.

    Science.gov (United States)

    Minen, Mia T; Monteith, Tesha; Strauss, Lauren D; Starling, Amaal

    2015-09-01

    We sought to survey the New Investigators and Trainees Section (NITS) members of the American Headache Society (AHS) to better understand their exposure to headache medicine during training and to determine their perceptions and attitudes about the field and the future of headache medicine. Despite the high prevalence of headache disorders in the general population, only about 2% of neurology residents pursue headache medicine fellowships. Furthermore, there is a paucity of United Council of Neurologic Subspecialties headache specialists in the country to meet the population demands. Thus, there needs to be a focus on how to recruit and retain more headache specialists. A survey was distributed via SurveyMonkey to the NITS listserv. It remained online for 60 days, during which reminder emails were sent to members of the listserv. In addition, the survey was available on laptops at NITS-related events at an annual AHS meeting. Descriptive analyses were then conducted using SurveyMonkey and Excel. Of the 93 members of NITS, 64 of the 96 (68.8%) clicked to initiate the survey and 52.7% successfully completed it. Attendings made up the majority of respondents (62.5%), followed by fellows (10.9%), and residents (7.8%). Key highlights of the survey included the following: just under 10% reported no exposure to a headache center during any time in their training (medical school, residency, or fellowship); less than 2% had exposure to a headache center during medical school; less than half of participants reported exposure to a headache center in residency (45.3%) and during fellowship (43.4%). Having a mentor in the field, liking the patient population, and working in a headache center, 64.7%, 52.9%, and 41.2%, respectively, were the top ways in which participants became interested in headache. The journal Headache (56.9%), attendings (56.3%), and the AHS/American Academy of Neurology guidelines for migraine management (52.0%) are the resources cited as being used all

  20. Thermodynamic Driving Force of Hydrogen on Rumen Microbial Metabolism: A Theoretical Investigation.

    Science.gov (United States)

    van Lingen, Henk J; Plugge, Caroline M; Fadel, James G; Kebreab, Ermias; Bannink, André; Dijkstra, Jan

    2016-01-01

    Hydrogen is a key product of rumen fermentation and has been suggested to thermodynamically control the production of the various volatile fatty acids (VFA). Previous studies, however, have not accounted for the fact that only thermodynamic near-equilibrium conditions control the magnitude of reaction rate. Furthermore, the role of NAD, which is affected by hydrogen partial pressure (PH2), has often not been considered. The aim of this study was to quantify the control of PH2 on reaction rates of specific fermentation pathways, methanogenesis and NADH oxidation in rumen microbes. The control of PH2 was quantified using the thermodynamic potential factor (FT), which is a dimensionless factor that corrects a predicted kinetic reaction rate for the thermodynamic control exerted. Unity FT was calculated for all glucose fermentation pathways considered, indicating no inhibition of PH2 on the production of a specific type of VFA (e.g., acetate, propionate and butyrate) in the rumen. For NADH oxidation without ferredoxin oxidation, increasing PH2 within the rumen physiological range decreased FT from unity to zero for different NAD+ to NADH ratios and pH of 6.2 and 7.0, which indicates thermodynamic control of PH2. For NADH oxidation with ferredoxin oxidation, increasing PH2 within the rumen physiological range decreased FT from unity at pH of 7.0 only. For the acetate to propionate conversion, FT increased from 0.65 to unity with increasing PH2, which indicates thermodynamic control. For propionate to acetate and butyrate to acetate conversions, FT decreased to zero below the rumen range of PH2, indicating full thermodynamic suppression. For methanogenesis by archaea without cytochromes, FT differed from unity only below the rumen range of PH2, indicating no thermodynamic control. This theoretical investigation shows that thermodynamic control of PH2 on individual VFA produced and associated yield of hydrogen and methane cannot be explained without considering NADH

  1. Thermodynamic Driving Force of Hydrogen on Rumen Microbial Metabolism: A Theoretical Investigation.

    Directory of Open Access Journals (Sweden)

    Henk J van Lingen

    Full Text Available Hydrogen is a key product of rumen fermentation and has been suggested to thermodynamically control the production of the various volatile fatty acids (VFA. Previous studies, however, have not accounted for the fact that only thermodynamic near-equilibrium conditions control the magnitude of reaction rate. Furthermore, the role of NAD, which is affected by hydrogen partial pressure (PH2, has often not been considered. The aim of this study was to quantify the control of PH2 on reaction rates of specific fermentation pathways, methanogenesis and NADH oxidation in rumen microbes. The control of PH2 was quantified using the thermodynamic potential factor (FT, which is a dimensionless factor that corrects a predicted kinetic reaction rate for the thermodynamic control exerted. Unity FT was calculated for all glucose fermentation pathways considered, indicating no inhibition of PH2 on the production of a specific type of VFA (e.g., acetate, propionate and butyrate in the rumen. For NADH oxidation without ferredoxin oxidation, increasing PH2 within the rumen physiological range decreased FT from unity to zero for different NAD+ to NADH ratios and pH of 6.2 and 7.0, which indicates thermodynamic control of PH2. For NADH oxidation with ferredoxin oxidation, increasing PH2 within the rumen physiological range decreased FT from unity at pH of 7.0 only. For the acetate to propionate conversion, FT increased from 0.65 to unity with increasing PH2, which indicates thermodynamic control. For propionate to acetate and butyrate to acetate conversions, FT decreased to zero below the rumen range of PH2, indicating full thermodynamic suppression. For methanogenesis by archaea without cytochromes, FT differed from unity only below the rumen range of PH2, indicating no thermodynamic control. This theoretical investigation shows that thermodynamic control of PH2 on individual VFA produced and associated yield of hydrogen and methane cannot be explained without

  2. Hydrodynamic investigation of a self-propelled robotic fish based on a force-feedback control method

    International Nuclear Information System (INIS)

    Wen, L; Wang, T M; Liang, J H; Wu, G H

    2012-01-01

    We implement a mackerel (Scomber scombrus) body-shaped robot, programmed to display the three most typical body/caudal fin undulatory kinematics (i.e. anguilliform, carangiform and thunniform), in order to biomimetically investigate hydrodynamic issues not easily tackled experimentally with live fish. The robotic mackerel, mounted on a servo towing system and initially at rest, can determine its self-propelled speed by measuring the external force acting upon it and allowing for the simultaneous measurement of power, flow field and self-propelled speed. Experimental results showed that the robotic swimmer with thunniform kinematics achieved a faster final swimming speed (St = 0.424) relative to those with carangiform (St = 0.43) and anguilliform kinematics (St = 0.55). The thrust efficiency, estimated from a digital particle image velocimetry (DPIV) flow field, showed that the robotic swimmer with thunniform kinematics is more efficient (47.3%) than those with carangiform (31.4%) and anguilliform kinematics (26.6%). Furthermore, the DPIV measurements illustrate that the large-scale characteristics of the flow pattern generated by the robotic swimmer with both anguilliform and carangiform kinematics were wedge-like, double-row wake structures. Additionally, a typical single-row reverse Karman vortex was produced by the robotic swimmer using thunniform kinematics. Finally, we discuss this novel force-feedback-controlled experimental method, and review the relative self-propelled hydrodynamic results of the robot when utilizing the three types of undulatory kinematics. (paper)

  3. The investigation of the light radiation caused polyethylene based materials deterioration by means of atomic force microscopy

    International Nuclear Information System (INIS)

    Sikora, A; Moroń, L; Wałecki, M; Kryla, P; Grabarek, A

    2016-01-01

    The impact of the environmental conditions on the materials used in various devices and constructions, in particular in electrotechnical applications, has an critical impact in terms of their reliability and utilization range in specific climatic conditions. Due to increasing utilitarian requirements, technological processes complexity and introducing new materials (for instance nanomaterials), advanced diagnostic techniques are desired. One of such techniques is atomic force microscopy (AFM), which allows to study the changes of the roughness and mechanical properties of the surface at the submicrometer scale, enabling the investigation of the degradation processes. In this work the deterioration of selected group of polyethylene based materials have been measured by means of AFM, as the samples were exposed to the simulated solar light and UV-C radiation. Such an analysis of the environmental conditions impact on the deterioration process using AFM methods for various versions of specific material was not presented before. (paper)

  4. Experimental Investigation of Temperature Distribution along the Length of Uniform Area Fin for Forced and Free Convection

    Science.gov (United States)

    Kannojiya, Vikas; Sharma, Riya; Gaur, Rahul; Jangra, Anil; Yadav, Pushpender; Prajapati, Pooja

    2018-03-01

    The overheating of an industrial component sometimes may leads to system failure. The convection heat transfer from a heated surface can be effectively enhanced by employing fins on that surface. This Paper emphasizes on the experimental investigation of temperature distribution along the length of pin shaped fin. The analysis is performed on a 100 mm long fin made up of brass with 19.6 mm diameter having thermal conductivity as 111 W/m.K. Temperature at different section of the fin along its length is evaluated experimentally and theoretically. The influence of convection mode viz natural & forced convection and variable heat input on the temperature distribution is evaluated. The result outcomes are then compared with the widely accepted analytical relations. A comparison of convective heat transfer coefficient for uniform and non-uniform area fin is also presented. The results by experimental and analytical method are found to be in good agreement for free convection phenomenon.

  5. Effects of temperature and cellular interactions on the mechanics and morphology of human cancer cells investigated by atomic force microscopy.

    Science.gov (United States)

    Li, Mi; Liu, LianQing; Xi, Ning; Wang, YueChao; Xiao, XiuBin; Zhang, WeiJing

    2015-09-01

    Cell mechanics plays an important role in cellular physiological activities. Recent studies have shown that cellular mechanical properties are novel biomarkers for indicating the cell states. In this article, temperature-controllable atomic force microscopy (AFM) was applied to quantitatively investigate the effects of temperature and cellular interactions on the mechanics and morphology of human cancer cells. First, AFM indenting experiments were performed on six types of human cells to investigate the changes of cellular Young's modulus at different temperatures and the results showed that the mechanical responses to the changes of temperature were variable for different types of cancer cells. Second, AFM imaging experiments were performed to observe the morphological changes in living cells at different temperatures and the results showed the significant changes of cell morphology caused by the alterations of temperature. Finally, by co-culturing human cancer cells with human immune cells, the mechanical and morphological changes in cancer cells were investigated. The results showed that the co-culture of cancer cells and immune cells could cause the distinct mechanical changes in cancer cells, but no significant morphological differences were observed. The experimental results improved our understanding of the effects of temperature and cellular interactions on the mechanics and morphology of cancer cells.

  6. Force Drawdowns and Demographic Diversity: Investigating the Impact of Force Reductions on the Demographic Diversity of the U.S. Military

    Science.gov (United States)

    2015-01-01

    and After 2000s Drawdown: Air Force Officer . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204 D.1. Sample Legal Authorities and DoD...identify additional sources (i.e., snowball method). We also asked colleagues and interviewees if they could recommend other reports, articles, or...strategies, programs, and outcomes. We supplemented our electronic searches with snowball methods; we read reference lists of reports to identify other

  7. Investigation of the structure of nanocrystalline refractory oxides by X-ray diffraction, electron microscopy, and atomic force microscopy

    International Nuclear Information System (INIS)

    Ulyanova, T. M.; Titova, L. V.; Medichenko, S. V.; Zonov, Yu. G.; Konstantinova, T. E.; Glazunova, V. A.; Doroshkevich, A. S.; Kuznetsova, T. A.

    2006-01-01

    The structures of nanocrystalline fibrous powders of refractory oxides have been investigated by different methods: determination of coherent-scattering regions, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and atomic-force microscopy (AFM). The sizes of nanograins of different crystalline phases of refractory metal oxides have been determined during the formation of these nanograins and the dynamics of their growth during heat treatment in the temperature range 600-1600 deg. C has been studied. The data on the structure of nanocrystalline refractory oxide powders, obtained by different methods, are in good agreement. According to the data on coherent-scattering regions, the sizes of the ZrO 2 (Y 2 O 3 ) and Al 2 O 3 grains formed are in the range 4-6 nm, and the particle sizes determined according to the TEM and AFM data are in the ranges 5-7 and 2-10 nm, respectively. SEM analysis made it possible to investigate the dynamics of nanoparticle growth at temperatures above 1000 deg. C and establish the limiting temperatures of their consolidation in fibers

  8. Experimental investigation on TBAB clathrate hydrate slurry flows in a horizontal tube: Forced convective heat transfer behaviors

    Energy Technology Data Exchange (ETDEWEB)

    Wenji, Song [Guangzhou Institute of Energy Conversion, CAS, No. 2 Nengyuan Road, Tianhe District, Guangzhou 510640 (China); Key Laboratory of Renewable Energy and Gas Hydrate, CAS, No. 2 Nengyuan Road, Tianhe District, Guangzhou 510640 (China); Graduate School of Chinese Academy of Sciences, Beijing 100039 (China); Rui, Xiao; Chong, Huang; Shihui, He; Kaijun, Dong; Ziping, Feng [Guangzhou Institute of Energy Conversion, CAS, No. 2 Nengyuan Road, Tianhe District, Guangzhou 510640 (China); Key Laboratory of Renewable Energy and Gas Hydrate, CAS, No. 2 Nengyuan Road, Tianhe District, Guangzhou 510640 (China)

    2009-11-15

    Tetra-n-butyl-ammonium bromide (TBAB) clathrate hydrate slurry (CHS) is one kind of secondary refrigerants, which is promising to be applied into air-conditioning or latent-heat transportation systems as a thermal storage or cold carrying medium for energy saving. It is a solid-liquid two phase mixture which is easy to produce and has high latent heat and good fluidity. In this paper, the heat transfer characteristics of TBAB slurry were investigated in a horizontal stainless steel tube under different solid mass fractions and flow velocities with constant heat flux. One velocity region of weakened heat transfer was found. Moreover, TBAB CHS was treated as a kind of Bingham fluids, and the influences of the solid particles, flow velocity and types of flow on the forced convective heat transfer coefficients of TBAB CHS were investigated. At last, criterial correlations of Nusselt number for laminar and turbulent flows in the form of power function were summarized, and the error with experimental results was within {+-}20%. (author)

  9. Investigation of the surface potential of TiO2 (110) by frequency-modulation Kelvin probe force microscopy

    Science.gov (United States)

    Kou, Lili; Li, Yan Jun; Kamijyo, Takeshi; Naitoh, Yoshitaka; Sugawara, Yasuhiro

    2016-12-01

    We investigate the surface potential distribution on a TiO2 (110)-1 × 1 surface by Kelvin probe force microscopy (KPFM) and atom-dependent bias-distance spectroscopic mapping. The experimental results demonstrate that the local contact potential difference increases on twofold-coordinated oxygen sites, and decreases on OH defects and fivefold-coordinated Ti sites. We propose a qualitative model to explain the origin of the surface potential of TiO2 (110). We qualitatively calculate the surface potential induced by chemical potential and permanent surface dipole. The calculated results agree with our experimental ones. Therefore, we suggest that the surface potential of TiO2 (110) is dominated not only by the permanent surface dipole between the tip apex atom and surface, but also by the dipoles induced by the chemical interaction between the tip and sample. The KPFM technique demonstrate the possibility of investigation of the charge transfer phenomenon on TiO2 surface under gas conditions. It is useful for the elucidation of the mechanism of the catalytic reactions.

  10. Investigation on the Effect of a Pre-Center Drill Hole and Tool Material on Thrust Force, Surface Roughness, and Cylindricity in the Drilling of Al7075

    Directory of Open Access Journals (Sweden)

    Amir Hossein Ghasemi

    2018-01-01

    Full Text Available Drilling is one of the most useful metal cutting processes and is used in various applications, such as aerospace, electronics, and automotive. In traditional drilling methods, the thrust force, torque, tolerance, and tribology (surface roughness are related to the cutting condition and tool geometry. In this paper, the effects of a pre-center drill hole, tool material, and drilling strategy (including continuous and non-continuous feed on thrust force, surface roughness, and dimensional accuracy (cylindricity have been investigated. The results show that using pre-center drill holes leads to a reduction of the engagement force and an improvement in the surface quality and cylindricity. Non-continuous drilling reduces the average thrust force and cylindricity value, and High Speed Steels HSS-Mo (high steel speed + 5–8% Mo reduces the maximum quantity of cutting forces. Moreover, cylindricity is directly related to cutting temperature and is improved by using a non-continuous drilling strategy.

  11. Investigation on the Effect of a Pre-Center Drill Hole and Tool Material on Thrust Force, Surface Roughness, and Cylindricity in the Drilling of Al7075.

    Science.gov (United States)

    Ghasemi, Amir Hossein; Khorasani, Amir Mahyar; Gibson, Ian

    2018-01-16

    Drilling is one of the most useful metal cutting processes and is used in various applications, such as aerospace, electronics, and automotive. In traditional drilling methods, the thrust force, torque, tolerance, and tribology (surface roughness) are related to the cutting condition and tool geometry. In this paper, the effects of a pre-center drill hole, tool material, and drilling strategy (including continuous and non-continuous feed) on thrust force, surface roughness, and dimensional accuracy (cylindricity) have been investigated. The results show that using pre-center drill holes leads to a reduction of the engagement force and an improvement in the surface quality and cylindricity. Non-continuous drilling reduces the average thrust force and cylindricity value, and High Speed Steels HSS-Mo (high steel speed + 5-8% Mo) reduces the maximum quantity of cutting forces. Moreover, cylindricity is directly related to cutting temperature and is improved by using a non-continuous drilling strategy.

  12. Theoretical Investigation of Peak-Delay Force Reduction for Caissons Exposed to Non-breaking Short-Crested Waves

    DEFF Research Database (Denmark)

    Burcharth, H. F.; Liu, Z.

    In nature coastal structures are exposed to oblique short-crested waves. The effect of wave incident angle on total wave force on a long caisson are twofold. The one is the force reduction due to the reduction of instantaneous point pressure on the caisson, named point-pressure force reduction....... The other is the force reduction due to the fact that the peak pressures do not occur simultaneously along the caisson, named peak-delay force reduction. These two reduction effects can also be expected with short-crested waves, as the short-crestedness of waves means the spreading of wave energy over...... a range of incident angles. The peak-delay force reduction, i.e. no simultaneous peak along caisson, is of particular interest because the equipment improvement in construction enables the building of considerably long caissons. In Japan length of caissons exceeds often 100m. This paper will concentrate...

  13. Surface and electron emission properties of hydrogen-free diamond-like carbon films investigated by atomic force microscopy

    International Nuclear Information System (INIS)

    Liu Dongping; Zhang, Sam; Ong, S.-E.; Benstetter, Guenther; Du Hejun

    2006-01-01

    In this study, we have deposited hydrogen-free diamond-like carbon (DLC) films by using DC magnetron sputtering of graphite target at various r.f. bias voltages. Surface and nanoscale emission properties of these DLC films have been investigated using a combination of atomic force microscopy (AFM)-based nanowear tests and conducting-AFM, by simultaneously measuring the topography and the conductivity of the samples. Nanowear tests show that these DLC films are covered with the thin (1.5-2.0 nm) graphite-like layers at surfaces. Compared to the film bulk structure, the graphite-like surface layers are more conductive. The graphite-like surface layers significantly influence the electron emission properties of these films. Low-energy carbon species can be responsible for the formation of graphite-like surface layers. Nanoscale electron emission measurements have revealed the inhomogeneous emission nature of these films. The low-field emission from these films can be attributed to the existence of sp 2 -configured nanoclusters inside the films

  14. Effect of plasma CVD operating temperature on nanomechanical properties of TiC nanostructured coating investigated by atomic force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Shanaghi, Ali, E-mail: alishanaghi@gmail.com [Materials Engineering Department, Faculty of Engineering, Malayer University, P.O. Box: 95863-65719, Malayer (Iran, Islamic Republic of); Rouhaghdam, Ali Reza Sabour, E-mail: sabour01@modares.ac.ir [Surface Engineering Laboratory, Materials Engineering Department, Faculty of Engineering, Tarbiat Modares University, P.O. Box: 14115-143, Tehran (Iran, Islamic Republic of); Ahangarani, Shahrokh, E-mail: sh.ahangarani@gmail.com [Advanced Materials and Renewable Energies Department, Iranian Research Organization for Science and Technology, P.O. Box 15815-3538, Tehran (Iran, Islamic Republic of); Chu, Paul K., E-mail: paul.chu@cityu.edu.hk [Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong (China)

    2012-09-15

    Highlights: ► The TiC{sub x} nanostructure coatings have been deposited by PACVD method. ► Dominant mechanism of growth structure at 490 °C is island-layer type. ► TiC{sub x} nanostructure coating applied at 490 °C, exhibits lowest friction coefficient. ► Young's moduli are 289.9, 400 and 187.6 GPa for 470, 490 and 510 °C, respectively. ► This higher elastic modulus and higher hardness of nanocoating obtain at 490 °C. -- Abstract: The structure, composition, and mechanical properties of nanostructured titanium carbide (TiC) coatings deposited on H{sub 11} hot-working tool steel by pulsed-DC plasma assisted chemical vapor deposition at three different temperatures are investigated. Nanoindentation and nanoscratch tests are carried out by atomic force microscopy to determine the mechanical properties such as hardness, elastic modulus, surface roughness, and friction coefficient. The nanostructured TiC coatings prepared at 490 °C exhibit lower friction coefficient (0.23) than the ones deposited at 470 and 510 °C. Increasing the deposition temperature reduces the Young's modulus and hardness. The overall superior mechanical properties such as higher hardness and lower friction coefficient render the coatings deposited at 490 °C suitable for wear resistant applications.

  15. Numerical investigation of laminar forced convection heat transfer in rectangular channels with different block geometries using nano-fluids

    Directory of Open Access Journals (Sweden)

    Foroutani Saeed

    2017-01-01

    Full Text Available This research investigates the laminar steady-forced convection heat transfer of a Cu-water nanofluid in a 2-D horizontal channel with different block geometries attached to the bottom wall. The block geometries assumed in this research are triangular and curve blocks. The governing equations associated with the required boundary conditions are solved using finite volume method based on the SIMPLE technique and the effects of Reynolds number, nanofluid volume fraction, block geometry, and the numbers of blocks on the local and average Nusselt numbers are explored. The obtained results show that nanoparticles can effectively enhance the heat transfer in a channel. Furthermore, the local and average Nusselt number distribution is strongly dependent on the block geometry. As observed, the heat transfer augments with the increase in the Reynolds number and nanofluid volume fraction for both block geometries. It is also concluded that the average Nusselt number of the curve block is higher than that of the triangular block for different Reynolds numbers which declares the importance of the block geometry in the heat transfer enhancement.

  16. Effect of plasma CVD operating temperature on nanomechanical properties of TiC nanostructured coating investigated by atomic force microscopy

    International Nuclear Information System (INIS)

    Shanaghi, Ali; Rouhaghdam, Ali Reza Sabour; Ahangarani, Shahrokh; Chu, Paul K.

    2012-01-01

    Highlights: ► The TiC x nanostructure coatings have been deposited by PACVD method. ► Dominant mechanism of growth structure at 490 °C is island-layer type. ► TiC x nanostructure coating applied at 490 °C, exhibits lowest friction coefficient. ► Young's moduli are 289.9, 400 and 187.6 GPa for 470, 490 and 510 °C, respectively. ► This higher elastic modulus and higher hardness of nanocoating obtain at 490 °C. -- Abstract: The structure, composition, and mechanical properties of nanostructured titanium carbide (TiC) coatings deposited on H 11 hot-working tool steel by pulsed-DC plasma assisted chemical vapor deposition at three different temperatures are investigated. Nanoindentation and nanoscratch tests are carried out by atomic force microscopy to determine the mechanical properties such as hardness, elastic modulus, surface roughness, and friction coefficient. The nanostructured TiC coatings prepared at 490 °C exhibit lower friction coefficient (0.23) than the ones deposited at 470 and 510 °C. Increasing the deposition temperature reduces the Young's modulus and hardness. The overall superior mechanical properties such as higher hardness and lower friction coefficient render the coatings deposited at 490 °C suitable for wear resistant applications.

  17. Influence of inhomogeneous coercivities on media noise in granular perpendicular media investigated by using magnetic force microscopy

    International Nuclear Information System (INIS)

    Bai, J.; Takahoshi, H.; Ito, H.; Rheem, Y.W.; Saito, H.; Ishio, S.

    2004-01-01

    We investigated the influence of the inhomogeneous coercivities on the media noise in a CoPtCr-SiO 2 granular perpendicular magnetic recording medium via ex situ and in situ magnetic force microscopy (MFM) techniques. The ex situ MFM analyses exhibited that transition zigzags contributed to strong magnetic clusters in noise images, and thus resulted in dominant component of the media noise. According to the in situ MFM measurements, it was suggested that an amount of magnetic grains inside a microscopic area reversed like one magnetic ''particle because of strong inter-grain exchange coupling, and that these microscopic areas showed their local magnetic switching behaviors. A mathematic transformation was used to obtain approximately the magnetization distribution in recording layer. And the individual microscopic areas inside recorded bits were compared quasi-quantitatively with those leading large transition zigzags in magnetization switching behaviors. It was indicated that the inhomogeneous coercivities is one of crucial reasons of the medium noise in the perpendicular magnetic recording

  18. On-site Identification of Dynamic Annular Seal Forces in Turbo Machinery Using Active Magnetic Bearings - An Experimental Investigation

    DEFF Research Database (Denmark)

    Lauridsen, Jonas S.; Santos, Ilmar F.

    2017-01-01

    Significant dynamic forces can be generated by annular seals in rotordynamics and can under certain conditions destabilize the system leading to machine failure. Mathematical modelling of dynamic seal forces are still challenging, especially for multiphase fluids and for seals with complex...... geometries. This results in much uncertainty in the estimation of the dynamic seal forces which often leads to unexpected system behaviour. This paper presents the results of a method suitable for on-site identification of uncertain dynamic annular seal forces in rotordynamic systems supported by Active...... Magnetic Bearings (AMB). An excitation current is applied through the AMBs to obtain perturbation forces and a system response, from which, the seal coefficients are extracted by utilizing optimization and a-priori information about the mathematical model structure and its known system dynamics. As a study...

  19. 'SOSORT consensus paper on brace action: TLSO biomechanics of correction (investigating the rationale for force vector selection'

    Directory of Open Access Journals (Sweden)

    Maruyama T

    2006-07-01

    Full Text Available Abstract Background The effectiveness of orthotic treatment continues to be controversial in international medical literature due to differences in the reported results and conclusions of various studies. Heterogeneity of the samples has been suggested as a reason for conflicting results. Besides the obvious theoretical differences between the brace concepts, the variability in the technical factors can also explain the contradictory results between same brace types. This paper will investigate the degree of variability among responses of scoliosis specialists from the Brace Study Ground of the International Society on Scoliosis Orthopedic and Rehabilitation Treatment SOSORT. Ultimately, this information could be a foundation for establishing a consensus and framework for future prospective controlled studies. Methods A preliminary questionnaire on the topic of 'brace action' relative to the theory of three-dimensional scoliosis correction and brace treatment was developed and circulated to specialists interested in the conservative treatment of adolescent idiopathic scoliosis. A particular case was presented (main thoracic curve with minor lumbar. Several key points emerged and were used to develop a second questionnaire which was discussed and full filed after the SOSORT consensus meeting (Milano, Italy, January 2005. Results Twenty-one questionnaires were completed. The Chêneau brace was the most frequently recommended. The importance of the three point system mechanism was stressed. Options about proper pad placement on the thoracic convexity were divided 50% for the pad reaching or involving the apical vertebra and 50% for the pad acting caudal to the apical vertebra. There was agreement about the direction of the vector force, 85% selecting a 'dorso lateral to ventro medial' direction but about the shape of the pad to produce such a force. Principles related to three-dimensional correction achieved high consensus (80%–85%, but suggested

  20. An investigation of the influence of strength mis-matching and HAZ width on the fracture behaviour of welds with cracks in the WM/HAZ interface

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, D.M.; Menezes, L.F.; Loureiro, A. [Dept of Mechanical Eng., FCTUC, Coimbra (Portugal)

    2004-07-01

    In this paper a numerical study concerning the influence of the mis-match in mechanical properties and of the heat affected zone width on the crack driving force of welds with cracks in the weld metal / heat affected zone interface is described. This work was performed through the numerical simulation of three-point bending tests, using finite element meshes of weld samples with various HAZ widths and two different crack length sizes. The numerical calculation of the J integral and of the stress fields ahead the notch tip was used to evaluate the fracture strength variation in the welds. (orig.)

  1. Investigation of the Effect of Internal Mold Release Agent and Filler on the Pulling Force in Pultrusion Process

    Directory of Open Access Journals (Sweden)

    M. Esfandeh

    2007-08-01

    Full Text Available Pulling force is one of the most important variables in pultrusion process which determines the capacity of the pultrusion machine. One of the characteristics of a desired pultrusion process is a low pulling force and a high line speed.Among the important factors affecting the pulling force are the internal mold release agent (IMR and the content and particle size of the filler in resin formulation. In addition to facilitating the part separation from the die, IMR also affects the curing kinetics and in turn the pulling force. In this research, a commercial IMR has been used in a range 1-5 phr. DSC and DMTAAnalyses showed that the presence of IMR in concentrations above 3 phr reduces the heat of curing reaction and also the curing rate. This results in an increase in pulling force. Study of filler effect showed that the increase in filler content from 4 to 8 phr reduces the pulling force but beyond that it is increased. Also, decreasing the filler particle size in line speed lower than 30 cm/min reduces the pulling force but increases it at higher line speed.

  2. An empirical investigation of female labor-force participation, fertility, age at marriage, and wages in Korea.

    Science.gov (United States)

    Lee, B S; Mcelwain, A M

    1985-07-01

    The Korean experience raises questions about the assumption that successful economic development and equitable income distribution are preconditions for rapid fertility declines. During the 1960-70 decade, the total fertility rate in Korea declined by 36% and the crude birth rate fell by 33%, in the absence of significant economic development. This paper uses data from the 1974 Korean Fertility Survey to explore the relationships between the factors responsible for this rapid fertility decline. A simultaneous equation model of fertility, age at marriage, extent of labor force participation during marriage, quality of children, and wages is developed and tested. Rather than to provide definitive measures of these interrelationships, the aim was to investigate the utility of treating several variables as being jointly determined. The results suggest that parental education affects fertility by influencing age at marriage, implying that adult education programs will have little effect on marital fertility. There was some evidence that working women whose jobs are compatible with child care have more children than nonworking women, a finding that should be considered in planning increased job opportunities for women. Urbanized women and those who work before marriage tend to marry later than their less urbanized counterparts or women who do not work prior to marriage. Finally, women who used modern methods of birth control had significantly lower fertility than nonusers of modern methods. There is concern that the Government has reduced budgetary appropriations to family planning since the goal of reducing the annual population growth rate from 3% in 1960 to 2% in 1970 was achieved. It is suggested that family planning expenditures should be deployed to areas such as urban slums that have not yet been reached by family planning programs.

  3. Multimodal Kelvin Probe Force Microscopy Investigations of a Photovoltaic WSe2/MoS2 Type-II Interface.

    Science.gov (United States)

    Almadori, Yann; Bendiab, Nedjma; Grévin, Benjamin

    2018-01-10

    Atomically thin transition-metal dichalcogenides (TMDC) have become a new platform for the development of next-generation optoelectronic and light-harvesting devices. Here, we report a Kelvin probe force microscopy (KPFM) investigation carried out on a type-II photovoltaic heterojunction based on WSe 2 monolayer flakes and a bilayer MoS 2 film stacked in vertical configuration on a Si/SiO 2 substrate. Band offset characterized by a significant interfacial dipole is pointed out at the WSe 2 /MoS 2 vertical junction. The photocarrier generation process and phototransport are studied by applying a differential technique allowing to map directly two-dimensional images of the surface photovoltage (SPV) over the vertical heterojunctions (vHJ) and in its immediate vicinity. Differential SPV reveals the impact of chemical defects on the photocarrier generation and that negative charges diffuse in the MoS 2 a few hundreds of nanometers away from the vHJ. The analysis of the SPV data confirms unambiguously that light absorption results in the generation of free charge carriers that do not remain coulomb-bound at the type-II interface. A truly quantitative determination of the electron-hole (e-h) quasi-Fermi levels splitting (i.e., the open-circuit voltage) is achieved by measuring the differential vacuum-level shift over the WSe 2 flakes and the MoS 2 layer. The dependence of the energy-level splitting as a function of the optical power reveals that Shockley-Read-Hall processes significantly contribute to the interlayer recombination dynamics. Finally, a newly developed time-resolved mode of the KPFM is applied to map the SPV decay time constants. The time-resolved SPV images reveal the dynamics of delayed recombination processes originating from photocarriers trapping at the SiO 2 /TMDC interfaces.

  4. Investigating the crystal growth behavior of biodegradable polymer blend thin films using in situ atomic force microscopy

    CSIR Research Space (South Africa)

    Malwela, T

    2014-01-01

    Full Text Available This article reports the crystal growth behavior of biodegradable polylactide (PLA)/poly[(butylene succinate)-co-adipate] (PBSA) blend thin films using atomic force microscopy (AFM). Currently, polymer thin films have received increased research...

  5. Coupling of continuum mechanics and electrodynamics:an investigation of electromagnetic force models by means of experiments and selected problems

    OpenAIRE

    Reich, Felix Alexander

    2017-01-01

    In the literature, many models of electromagnetic momentum are proposed. Each model implies a form of the electromagnetic force density, which acts as a source in the mechanical momentum balance. The debate as to which model of the electromagnetic force is "correct" for arbitrary materials and processes is ongoing. Most authors argue in favor or against specific models by virtue of thought experiments, e.g, with light waves. The topic of this work is to show that experiments conducted on a ma...

  6. Atomic force and optical near-field microscopic investigations of polarization holographic gratings in a liquid crystalline azobenzene side-chain polyester

    DEFF Research Database (Denmark)

    Ramanujam, P.S.; Holme, N.C.R.; Hvilsted, S.

    1996-01-01

    Atomic force and scanning near-field optical microscopic investigations have been carried out on a polarization holographic grating recorded in an azobenzene side-chain Liquid crystalline polyester. It has been found that immediately following laser irradiation, a topographic surface grating...

  7. Investigation of forced convection heat transfer of supercritical pressure water in a vertically upward internally ribbed tube

    International Nuclear Information System (INIS)

    Wang Jianguo; Li Huixiong; Guo Bin; Yu Shuiqing; Zhang Yuqian; Chen Tingkuan

    2009-01-01

    In the present paper, the forced convection heat transfer characteristics of water in a vertically upward internally ribbed tube at supercritical pressures were investigated experimentally. The six-head internally ribbed tube is made of SA-213T12 steel with an outer diameter of 31.8 mm and a wall thickness of 6 mm and the mean inside diameter of the tube is measured to be 17.6 mm. The experimental parameters were as follows. The pressure at the inlet of the test section varied from 25.0 to 29.0 MPa, and the mass flux was from 800 to 1200 kg/(m 2 s), and the inside wall heat flux ranged from 260 to 660 kW/m 2 . According to experimental data, the effects of heat flux and pressure on heat transfer of supercritical pressure water in the vertically upward internally ribbed tube were analyzed, and the characteristics and mechanisms of heat transfer enhancement, and also that of heat transfer deterioration, were also discussed in the so-called large specific heat region. The drastic changes in thermophysical properties near the pseudocritical points, especially the sudden rise in the specific heat of water at supercritical pressures, may result in the occurrence of the heat transfer enhancement, while the covering of the heat transfer surface by fluids lighter and hotter than the bulk fluid makes the heat transfer deteriorated eventually and explains how this lighter fluid layer forms. It was found that the heat transfer characteristics of water at supercritical pressures were greatly different from the single-phase convection heat transfer at subcritical pressures. There are three heat transfer modes of water at supercritical pressures: (1) normal heat transfer, (2) deteriorated heat transfer with low HTC but high wall temperatures in comparison to the normal heat transfer, and (3) enhanced heat transfer with high HTC and low wall temperatures in comparison to the normal heat transfer. It was also found that the heat transfer deterioration at supercritical pressures was

  8. Lipid domain formation and ligand-receptor distribution in lipid bilayer membranes investigated by atomic force microscopy

    DEFF Research Database (Denmark)

    Kaasgaard, Thomas; Mouritsen, O.G.; Jørgensen, K.

    2002-01-01

    A novel experimental technique, based on atomic force microscopy (AFM), is proposed to visualize the lateral organization of membrane systems in the nanometer range. The technique involves the use of a ligand-receptor pair, biotin-avidin, which introduces a height variation on a solid-supported l......A novel experimental technique, based on atomic force microscopy (AFM), is proposed to visualize the lateral organization of membrane systems in the nanometer range. The technique involves the use of a ligand-receptor pair, biotin-avidin, which introduces a height variation on a solid...

  9. Experimental investigation of forced-convection in a finned rhombic tube of the flat-plate solar collectors

    DEFF Research Database (Denmark)

    Taherian, Hessam; Yazdanshenas, Eshagh

    2006-01-01

    Due to scarcity of literature on forced-convection heat transfer in a solar collector with rhombic cross-section absorbing tubes, a series of experiments was arranged and conducted to determine heat transfer coefficient. In this study, a typical rhombic cross-section finned tube of flat...

  10. Combined piezoresponse force microscopyand Raman scattering investigation of domainboundaries in BiFeO.sub.3./sub. ceramics

    Czech Academy of Sciences Publication Activity Database

    Borodavka, Fedir; Pokorný, Jan; Hlinka, Jiří

    2016-01-01

    Roč. 89, 7-8 (2016), 746-751 ISSN 0141-1594 R&D Projects: GA ČR GA15-04121S Institutional support: RVO:68378271 Keywords : phase transition * BiFeO 3 * Raman scattering * piezoresponse force microscopy Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.060, year: 2016

  11. An experimental investigation on the effects of exponential window and impact force level on harmonic reduction in impact-synchronous model analysis

    Energy Technology Data Exchange (ETDEWEB)

    Chao, Ong Zhi; Cheet, Lim Hong; Yee, Khoo Shin [Mechanical Engineering Department, Faculty of EngineeringUniversity of Malaya, Kuala Lumpur (Malaysia); Rahman, Abdul Ghaffar Abdul [Faculty of Mechanical Engineering, University Malaysia Pahang, Pekan (Malaysia); Ismail, Zubaidah [Civil Engineering Department, Faculty of Engineering, University of Malaya, Kuala Lumpur (Malaysia)

    2016-08-15

    A novel method called Impact-synchronous modal analysis (ISMA) was proposed previously which allows modal testing to be performed during operation. This technique focuses on signal processing of the upstream data to provide cleaner Frequency response function (FRF) estimation prior to modal extraction. Two important parameters, i.e., windowing function and impact force level were identified and their effect on the effectiveness of this technique were experimentally investigated. When performing modal testing during running condition, the cyclic loads signals are dominant in the measured response for the entire time history. Exponential window is effectively in minimizing leakage and attenuating signals of non-synchronous running speed, its harmonics and noises to zero at the end of each time record window block. Besides, with the information of the calculated cyclic force, suitable amount of impact force to be applied on the system could be decided prior to performing ISMA. Maximum allowable impact force could be determined from nonlinearity test using coherence function. By applying higher impact forces than the cyclic loads along with an ideal decay rate in ISMA, harmonic reduction is significantly achieved in FRF estimation. Subsequently, the dynamic characteristics of the system are successfully extracted from a cleaner FRF and the results obtained are comparable with Experimental modal analysis (EMA)

  12. An experimental investigation on the effects of exponential window and impact force level on harmonic reduction in impact-synchronous model analysis

    International Nuclear Information System (INIS)

    Chao, Ong Zhi; Cheet, Lim Hong; Yee, Khoo Shin; Rahman, Abdul Ghaffar Abdul; Ismail, Zubaidah

    2016-01-01

    A novel method called Impact-synchronous modal analysis (ISMA) was proposed previously which allows modal testing to be performed during operation. This technique focuses on signal processing of the upstream data to provide cleaner Frequency response function (FRF) estimation prior to modal extraction. Two important parameters, i.e., windowing function and impact force level were identified and their effect on the effectiveness of this technique were experimentally investigated. When performing modal testing during running condition, the cyclic loads signals are dominant in the measured response for the entire time history. Exponential window is effectively in minimizing leakage and attenuating signals of non-synchronous running speed, its harmonics and noises to zero at the end of each time record window block. Besides, with the information of the calculated cyclic force, suitable amount of impact force to be applied on the system could be decided prior to performing ISMA. Maximum allowable impact force could be determined from nonlinearity test using coherence function. By applying higher impact forces than the cyclic loads along with an ideal decay rate in ISMA, harmonic reduction is significantly achieved in FRF estimation. Subsequently, the dynamic characteristics of the system are successfully extracted from a cleaner FRF and the results obtained are comparable with Experimental modal analysis (EMA)

  13. Origin of phase shift in atomic force microscopic investigation of the surface morphology of NR/NBR blend film

    Energy Technology Data Exchange (ETDEWEB)

    Thanawan, S. [Institute of Science and Technology for Research and Development, Mahidol University, Salaya, Nakhon Pathom 73170 (Thailand)], E-mail: ststw@mahidol.ac.th; Radabutra, S.; Thamasirianunt, P.; Amornsakchai, T.; Suchiva, K. [Department of Chemistry, Faculty of Science, Mahidol University, Salaya, Nakhon Pathom 73170 (Thailand)

    2009-01-15

    Atomic force microscopy (AFM) was used to study the morphology and surface properties of NR/NBR blend. Blends at 1/3, 1/1 and 3/1 weight ratios were prepared in benzene and formed film by casting. AFM phase images of these blends in tapping mode displayed islands in the sea morphology or matrix-dispersed structures. For blend 1/3, NR formed dispersed phase while in blends 1/1 and 3/1 phase inversion was observed. NR showed higher phase shift angle in AFM phase imaging for all blends. This circumstance was governed by adhesion energy hysteresis between the device tip and the rubber surface rather than surface stiffness of the materials, as proved by force distance measurements in the AFM contact mode.

  14. Origin of phase shift in atomic force microscopic investigation of the surface morphology of NR/NBR blend film.

    Science.gov (United States)

    Thanawan, S; Radabutra, S; Thamasirianunt, P; Amornsakchai, T; Suchiva, K

    2009-01-01

    Atomic force microscopy (AFM) was used to study the morphology and surface properties of NR/NBR blend. Blends at 1/3, 1/1 and 3/1 weight ratios were prepared in benzene and formed film by casting. AFM phase images of these blends in tapping mode displayed islands in the sea morphology or matrix-dispersed structures. For blend 1/3, NR formed dispersed phase while in blends 1/1 and 3/1 phase inversion was observed. NR showed higher phase shift angle in AFM phase imaging for all blends. This circumstance was governed by adhesion energy hysteresis between the device tip and the rubber surface rather than surface stiffness of the materials, as proved by force distance measurements in the AFM contact mode.

  15. An Investigation of the Factors which Affect the Career Selection Process of Air Force Systems Command Company Grade Officers.

    Science.gov (United States)

    1979-12-01

    faction, occupational preference, or the desirability of good performance . Proposition 2, as formulated by Vroom , predicts the force to act in a...Human Performance , 9: 482-503 (1973). Lewis, Logan M. "Expectancy Theory as a Predictive Model of Career Intent, Job Satisfaction , and Institution... Satisfaction , Effort, Performance , and Retention of Naval Aviation Officers," Organizational Behavior and Human Performance , 8: 1-20 (1972). 102 and Lee Roy

  16. Combined friction force microscopy and quantum chemical investigation of the tribotronic response at the propylammonium nitrate-graphite interface.

    Science.gov (United States)

    Li, H; Atkin, R; Page, A J

    2015-06-28

    The energetic origins of the variation in friction with potential at the propylammonium nitrate-graphite interface are revealed using friction force microscopy (FFM) in combination with quantum chemical simulations. For boundary layer lubrication, as the FFM tip slides energy is dissipated via (1) boundary layer ions and (2) expulsion of near-surface ion layers from the space between the surface and advancing tip. Simulations reveal how changing the surface potential changes the ion composition of the boundary and near surface layer, which controls energy dissipation through both pathways, and thus the friction.

  17. An investigation of force components in orthogonal cutting of medical grade cobalt-chromium alloy (ASTM F1537).

    Science.gov (United States)

    Baron, Szymon; Ahearne, Eamonn

    2017-04-01

    An ageing population, increased physical activity and obesity are identified as lifestyle changes that are contributing to the ongoing growth in the use of in-vivo prosthetics for total hip and knee arthroplasty. Cobalt-chromium-molybdenum (Co-Cr-Mo) alloys, due to their mechanical properties and excellent biocompatibility, qualify as a class of materials that meet the stringent functional requirements of these devices. To cost effectively assure the required dimensional and geometric tolerances, manufacturers rely on high-precision machining. However, a comprehensive literature review has shown that there has been limited research into the fundamental mechanisms in mechanical cutting of these alloys. This article reports on the determination of the basic cutting-force coefficients in orthogonal cutting of medical grade Co-Cr-Mo alloy ASTM F1537 over an extended range of cutting speeds ([Formula: see text]) and levels of undeformed chip thickness ([Formula: see text]). A detailed characterisation of the segmented chip morphology over this range is also reported, allowing for an estimation of the shear plane angle and, overall, providing a basis for macro-mechanic modelling of more complex cutting processes. The results are compared with a baseline medical grade titanium alloy, Ti-6Al-4V ASTM F136, and it is shown that the tangential and thrust-force components generated were, respectively, ≈35% and ≈84% higher, depending primarily on undeformed chip thickness but with some influence of the cutting speed.

  18. Simplified tunnelling current calculation for MOS structures with ultra-thin oxides for conductive atomic force microscopy investigations

    International Nuclear Information System (INIS)

    Frammelsberger, Werner; Benstetter, Guenther; Stamp, Richard; Kiely, Janice; Schweinboeck, Thomas

    2005-01-01

    As charge tunnelling through thin and ultra-thin silicon dioxide layers is regarded as the driving force for MOS device degradation the determination and characterisation of electrically week spots is of paramount importance for device reliability and failure analysis. Conductive atomic force microscopy (C-AFM) is able to address this issue with a spatial resolution smaller than the expected breakdown spot. For the determination of the electrically active oxide thickness in practice an easy to use model with sufficient accuracy and which is largely independent of the oxide thickness is required. In this work a simplified method is presented that meets these demands. The electrically active oxide thickness is determined by matching of C-AFM voltage-current curves and a tunnelling current model, which is based on an analytical tunnelling current approximation. The model holds for both the Fowler-Nordheim tunnelling and the direct tunnelling regime with one single tunnelling parameter set. The results show good agreement with macroscopic measurements for gate voltages larger than approximately 0.5-1 V, and with microscopic C-AFM measurements. For this reason arbitrary oxides in the DT and the FNT regime may be analysed with high lateral resolution by C-AFM, without the need of a preselection of the tunnelling regime to be addressed

  19. Preliminary investigation on the relationship of Raman spectra of sheep meat with shear force and cooking loss.

    Science.gov (United States)

    Schmidt, Heinar; Scheier, Rico; Hopkins, David L

    2013-01-01

    A prototype handheld Raman system was used as a rapid non-invasive optical device to measure raw sheep meat to estimate cooked meat tenderness and cooking loss. Raman measurements were conducted on m. longissimus thoracis et lumborum samples from two sheep flocks from two different origins which had been aged for five days at 3-4°C before deep freezing and further analysis. The Raman data of 140 samples were correlated with shear force and cooking loss data using PLS regression. Both sample origins could be discriminated and separate correlation models yielded better correlations than the joint correlation model. For shear force, R(2)=0.79 and R(2)=0.86 were obtained for the two sites. Results for cooking loss were comparable: separate models yielded R(2)=0.79 and R(2)=0.83 for the two sites. The results show the potential usefulness of Raman spectra which can be recorded during meat processing for the prediction of quality traits such as tenderness and cooking loss. Copyright © 2012 Elsevier Ltd. All rights reserved.

  20. Crack nucleation and elastic / plastic deformation of TiAl alloys investigated by in-situ loaded atomic force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Iqbal, F.; Pyczak, F.; Neumeier, S.; Göken, M.

    2017-03-24

    The crack propagation mechanisms of γ-titanium aluminides with fully lamellar microstructure have been studied using in-situ deformation in the Atomic Force Microscope (AFM). AFM demonstrated the unique capability to detect elastic as well as plastic deformation during in-situ tests from topography changes on the surface. It was found that the crack nucleation, which can occur at γ/γ and α{sub 2}/γ interfaces as well as inside the γ-phase, is always preceded by strong local elastic deformation. No cracking inside the α{sub 2}-phase was observed. The elastic and plastic deformation was confined inside the γ-phase and especially pronounced near interfaces which can be explained by the differences of the elastic and plastic deformation behavior of the γ- and α{sub 2}- phase.

  1. Experimental investigation of the dynamics of a hybrid morphing wing: time resolved particle image velocimetry and force measures

    Science.gov (United States)

    Jodin, Gurvan; Scheller, Johannes; Rouchon, Jean-François; Braza, Marianna; Mit Collaboration; Imft Collaboration; Laplace Collaboration

    2016-11-01

    A quantitative characterization of the effects obtained by high frequency-low amplitude trailing edge actuation is performed. Particle image velocimetry, as well as pressure and aerodynamic force measurements, are carried out on an airfoil model. This hybrid morphing wing model is equipped with both trailing edge piezoelectric-actuators and camber control shape memory alloy actuators. It will be shown that this actuation allows for an effective manipulation of the wake turbulent structures. Frequency domain analysis and proper orthogonal decomposition show that proper actuating reduces the energy dissipation by favoring more coherent vortical structures. This modification in the airflow dynamics eventually allows for a tapering of the wake thickness compared to the baseline configuration. Hence, drag reductions relative to the non-actuated trailing edge configuration are observed. Massachusetts Institute of Technology.

  2. Mining spatial information to investigate the evolution of karst rocky desertification and its human driving forces in Changshun, China.

    Science.gov (United States)

    Xu, Erqi; Zhang, Hongqi; Li, Mengxian

    2013-08-01

    The processes of karst rocky desertification (KRD) have been found to cause the most severe environmental degradation in southwestern China. Understanding the driving forces that cause KRD is essential for managing and restoring the areas that it impacts. Studies of the human driving forces of KRD are limited to the county level, a specific administrative unit in China; census data are acquired at this scale, which can lead to scale biases. Changshun County is studied here as a representative area and anthropogenic influences in the county are accounted for by using Euclidean distances for the proximity to roads and settlements. We propose a standard coefficient of human influence (SOI) that standardizes the Euclidean distances for different KRD transformations to compare the effects of human activities in different areas. In Changshun County, the individual influences of roads and settlements share similar characteristics. The SOIs of improved KRD transformation types are almost negative, but the SOIs of deteriorated types are nearly positive except for one form of KRD turning to the extremely severe KRD. The results indicated that the distribution and evolution of the KRD areas from 2000 to 2010 in Changshun were affected positively by human activities (e.g., KRD restoration projects) and also negatively (e.g., by intense and irrational land use). Our results demonstrate that the spatial techniques and SOI used in this study can effectively incorporate information concerning human influences and internal KRD transformations. This provides a suitable approach for studying the relationships between human activities and KRD processes at fine scales. Copyright © 2013 Elsevier B.V. All rights reserved.

  3. MDM2–MDM4 molecular interaction investigated by atomic force spectroscopy and surface plasmon resonance

    Directory of Open Access Journals (Sweden)

    Moscetti I

    2016-08-01

    Full Text Available Ilaria Moscetti,1 Emanuela Teveroni,2,3 Fabiola Moretti,3 Anna Rita Bizzarri,1 Salvatore Cannistraro1 1Biophysics and Nanoscience Centre, Department DEB, Università della Tuscia, Viterbo, Italy; 2Department of Endocrinology and Metabolism, Università Cattolica di Roma, Roma, Italy; 3Institute of Cell Biology and Neurobiology, Consiglio Nazionale delle Ricerche (CNR, Roma, Italy Abstract: Murine double minute 2 (MDM2 and 4 (MDM4 are known as the main negative regulators of p53, a tumor suppressor. They are able to form heterodimers that are much more effective in the downregulation of p53. Therefore, the MDM2–MDM4 complex could be a target for promising therapeutic restoration of p53 function. To this aim, a deeper understanding of the molecular mechanisms underlining the heterodimerization is needed. The kinetic and thermodynamic characterization of the MDM2–MDM4 complex was performed with two complementary approaches: atomic force spectroscopy and surface plasmon resonance. Both techniques revealed an equilibrium dissociation constant (KD in the micromolar range for the MDM2–MDM4 heterodimer, similar to related complexes involved in the p53 network. Furthermore, the MDM2–MDM4 complex is characterized by a relatively high free energy, through a single energy barrier, and by a lifetime in the order of tens of seconds. New insights into the MDM2–MDM4 interaction could be highly important for developing innovative anticancer drugs focused on p53 reactivation. Keywords: MDM2, MDM4, atomic force spectroscopy, surface plasmon resonance

  4. A Snapshot of Serial Rape: An Investigation of Criminal Sophistication and Use of Force on Victim Injury and Severity of the Assault.

    Science.gov (United States)

    de Heer, Brooke

    2016-02-01

    Prior research on rapes reported to law enforcement has identified criminal sophistication and the use of force against the victim as possible unique identifiers to serial rape versus one-time rape. This study sought to contribute to the current literature on reported serial rape by investigating how the level of criminal sophistication of the rapist and use of force used were associated with two important outcomes of rape: victim injury and overall severity of the assault. In addition, it was evaluated whether rapist and victim ethnicity affected these relationships. A nation-wide sample of serial rape cases reported to law enforcement collected by the Federal Bureau of Investigation (FBI) was analyzed (108 rapists, 543 victims). Results indicated that serial rapists typically used a limited amount of force against the victim and displayed a high degree of criminal sophistication. In addition, the more criminally sophisticated the perpetrator was, the more sexual acts he performed on his victim. Finally, rapes between a White rapist and White victim were found to exhibit higher levels of criminal sophistication and were more severe in terms of number and types of sexual acts committed. These findings provide a more in-depth understanding of serial rape that can inform both academics and practitioners in the field about contributors to victim injury and severity of the assault. © The Author(s) 2014.

  5. An experimental investigation of the efficacy of perforated holes on unsteady aerodynamic force reduction for a 2D cylinder in uniform incoming flow

    Science.gov (United States)

    Sudalaimuthu, Vignesh; Liu, Xiaofeng

    2017-11-01

    A series of wind tunnel aerodynamic force measurements have been conducted on a 2D hollow cylinder with perforated holes uniformly-distributed on its surface to evaluate the efficacy of perforation as a means of passive flow control in reducing unsteady aerodynamic forces. Both smooth and perforated cylinders were tested for comparison at Reynolds numbers ranging from 50,000 to 200,000 corresponding to free stream velocities varying from 5 to 20 m/s (at an increment of 5 m/s) and a cylinder diameter of 0.152 m. The aerodynamic forces acting on the testing model were measured using a 6-component load cell. For each tunnel speed, the test has been repeated for 10 runs at a sampling rate of 10 kHz for 60 seconds each, with a total of 6,000,000 samples acquired for each test. Both mean and r.m.s. values of the lift and drag coefficients were calculated. Power spectral density distributions of the unsteady aerodynamic force loading was analyzed to investigate the effect of the perforation on the frequency composition. Comparisons indicate that the perforated cylinder with a 8% porosity and a hole diameter of about 2% of that of the cylinder gives both substantially less unsteady drag and lift than those of the smooth cylinder for the entire Reynolds number range tested, with the r.m.s. force reduction from 8% to 82% for the drag and 64% to 85% for the lift, confirming a corresponding beneficial reduction in flow-induced cylinder vibration as observed during the experiments. Sponsor: San Diego State University.

  6. Assessing Influences on Perceived Training Transfer: An Investigation of Perceptions of Air Force Logistics Readiness Officer Technical School Graduates

    National Research Council Canada - National Science Library

    Hobbs, Sarah E

    2005-01-01

    .... This research specifically investigates how influences/attitudes/beliefs of LRO technical school graduates regarding their training influence their perceptions about the transfer of such training back to the job...

  7. Investigating effects of nano-particles infiltration on mechanical properties of cell membrane using atomic force microscopy

    Science.gov (United States)

    Zhang, XiaoYue; Zhang, Yong; Zheng, Yue; Wang, Biao

    2012-06-01

    In this paper, we introduce our finding of the effects of C60 nanoparticles (NP) infiltration on mechanical properties of cell and its membrane. Atomic force microscopy (AFM) is used to perform indentation on both normal and C60 infiltrated red blood cells (RBC) to gain data of mechanical characteristics of the membrane. Our results show that the mechanical properties of human RBC membrane seem to be altered due to the presence of C60 NPs. The resistance and ultimate strength of the C60 infiltrated RBC membrane significantly decrease. We also explain the mechanism of how C60 NPs infiltration changes the mechanical properties of the cell membrane by predicting the structural change of the lipid bilayer caused by the C60 infiltration at molecular level and analyze the interactions among molecules in the lipid bilayer. The potential hazards and application of the change in mechanical characteristics of the RBCs membrane are also discussed. Nanotoxicity of C60 NPs may be significant for some biological cells.

  8. Investigation of the loss of forced cooling test by using the high temperature engineering test reactor (HTTR) (Contract research)

    International Nuclear Information System (INIS)

    Nakagawa, Shigeaki; Takamatsu, Kuniyoshi; Inaba, Yoshitomo; Goto, Minoru; Tochio, Daisuke

    2007-09-01

    The three gas circulators trip test and the vessel cooling system stop test as the safety demonstration test by using the High Temperature engineering Test Reactor (HTTR) are under planning to demonstrate inherent safety features of High Temperature Gas-cooled Reactor. All three gas circulators to circulate the helium gas as the coolant are stopped to simulate the loss of forced cooling in the three gas circulators trip test. The stop of the vessel cooling system located outside the reactor pressure vessel to remove the residual heat of the reactor core follows the stop of all three gas circulators in the vessel cooling system stop test. The analysis of the reactor transient for such tests and abnormal events postulated during the test was performed. From the result of analysis, it was confirmed that the three gas circulators trip test and the vessel cooling system stop test can be performed within the region of the normal operation in the HTTR and the safety of the reactor facility is ensured even if the abnormal events would occur. (author)

  9. MDM2–MDM4 molecular interaction investigated by atomic force spectroscopy and surface plasmon resonance

    Science.gov (United States)

    Moscetti, Ilaria; Teveroni, Emanuela; Moretti, Fabiola; Bizzarri, Anna Rita; Cannistraro, Salvatore

    2016-01-01

    Murine double minute 2 (MDM2) and 4 (MDM4) are known as the main negative regulators of p53, a tumor suppressor. They are able to form heterodimers that are much more effective in the downregulation of p53. Therefore, the MDM2–MDM4 complex could be a target for promising therapeutic restoration of p53 function. To this aim, a deeper understanding of the molecular mechanisms underlining the heterodimerization is needed. The kinetic and thermodynamic characterization of the MDM2–MDM4 complex was performed with two complementary approaches: atomic force spectroscopy and surface plasmon resonance. Both techniques revealed an equilibrium dissociation constant (KD) in the micromolar range for the MDM2–MDM4 heterodimer, similar to related complexes involved in the p53 network. Furthermore, the MDM2–MDM4 complex is characterized by a relatively high free energy, through a single energy barrier, and by a lifetime in the order of tens of seconds. New insights into the MDM2–MDM4 interaction could be highly important for developing innovative anticancer drugs focused on p53 reactivation. PMID:27621617

  10. Investigating biological traces of traumatic stress in changing societies: challenges and directions from the ESTSS Task Force on Neurobiology

    Directory of Open Access Journals (Sweden)

    Kathleen Thomaes

    2016-03-01

    Full Text Available Traumatic stress can have severe consequences for both mental and physical health. Furthermore, both psychological and biological traces of trauma increase as a function of accumulating traumatic experiences. Neurobiological research may aid in limiting the impact of traumatic stress, by leading to advances in preventive and treatment interventions. To promote the possibility for clinical implementation of novel research findings, this brief review describes timely conceptual and methodological challenges and directions in neurobiological trauma research on behalf of the Task Force “Neurobiology of Traumatic Stress” of the European Society for Traumatic Stress Studies (ESTSS. The most important conceptual challenges are the heterogeneity of disorders and existence of subtypes across diagnostic categories: differential latent profiles and trajectories regarding symptom expression and neural correlates are being unraveled; however, similar latent classes’ approaches for treatment response and neurobiological data remain scarce thus far. The key to improving the efficacy of currently available preventive interventions and treatments for trauma-related disorders lies in a better understanding and characterization of individual differences in response to trauma and interventions. This could lead to personalized treatment strategies for trauma-related disorders, based on objective information indicating whether individuals are expected to benefit from them. The most important methodological challenge identified here is the need for large consortia and meta-analyses or, rather, mega-analyses on existent data as a first step. In addition, large multicenter studies, combining novel methods for repeated sampling with more advanced statistical modeling techniques, such as machine learning, should aim to translate identified disease mechanisms into molecular blood-based biomarker combinations to predict disorder vulnerability and treatment responses.

  11. Developing a programmatic approach to investigating and remediating many unrelated comprehensive environmental response, compensation, and liability act sites at Kelly Air Force Base

    International Nuclear Information System (INIS)

    Kamp, G.; Regan, P.; Ninesteel, R.; Martin, R.

    1988-01-01

    Kelly Air Force Base (AFB), which was founded in 1917, is involved in logistics and maintenance activities supporting the Air Logistics Command. In addition, Kelly AFB hosts over 50 tenant organizations representing the Air Force, Department of Defense, and other government agencies. Over the years waste disposal from this complex was conducted in a manner that led to the identification of over 30 sites to be included in the Installation Restoration Program (IRP) after the Phase 1 investigation. A methodology was needed to prioritize the Remedial Investigations and Feasibility Study (RI/FS) activities for the sites. A Strategy Plan was developed that involved reviewing and interpreting existing data, identifying data voids relative to site specific RI/FS activities, and developing methodology to prioritize activities. Sites were prioritized, and a comprehensive IRP planning document was developed. One data deficiency was revealed -- the lack of understanding of the Basewide hydrogeologic conditions necessary to establish an effective restoration program. A Hydrogeologic Investigation was initiated to provide this data. This data will allow better interpretation of the interaction of the sites, particularly those in close proximity, and improved planning of remediation activities

  12. Modulation of Calcium Oxalate Crystallization by Proteins and Small Molecules Investigated by In Situ Atomic Force Microscopy

    Science.gov (United States)

    Qiu, R.; Orme, C.; Cody, A. M.; Wierzbicki, A.; Hoyer, J.; Nancollas, G.; de Yoreo, J.

    2002-12-01

    Understanding the physical mechanisms by which biological inhibitors control nucleation and growth of inorganic crystals is a major focus of biomineral research. Calcium oxalate monohydrate (COM), which plays a functional role in plant physiology, is also a source of pathogenesis in humans where it causes kidney stone disease. Although a great deal of research has been carried out on the modulation COM by proteins and small molecules, the basic mechanism has not yet been understood. However, because the proteins that play a role in COM growth have been identified and sequenced, COM provides an excellent model system for research into biomineral growth. In this study, in situ atomic force microscopy (AFM) was used to monitor the COM surface under controlled growth conditions both from pure solutions and those doped with citrate and osteopontin (OPN) in order to determine their effects on surface morphology and growth dynamics at the molecular level. As with other solution-grown crystals such as calcite, COM grows on complex dislocation hillocks. In pure solution, while growth on the (010) face is isotropic, hillocks on the (-101) face exhibit anisotropic step kinetics. Steps of [-10-1] and orientation are clearly delineated with the [-10-1] being the fast growing direction. When citrate is added to the solution, both growth rate and morphology are drastically changed on (-101) face, especially along the [-10-1] direction. This results in isotropic disc-shaped hillocks a shape that is then reflected in the macroscopic growth habit. In contrast, no large growth changes were observed on the (010) facet. At the same time, molecular modeling predicts an excellent fit of the citrate ion into the (-101) plane and a poor fit to the (010) face. Here we propose a model that reconciles the step-specific interactions implied by the AFM results with the face-specific predictions of the calculations. Finally, we present the results of doping with aspartic acid as well as OPN, an

  13. Muscle Performance Investigated With a Novel Smart Compression Garment Based on Pressure Sensor Force Myography and Its Validation Against EMG.

    Science.gov (United States)

    Belbasis, Aaron; Fuss, Franz Konstantin

    2018-01-01

    Muscle activity and fatigue performance parameters were obtained and compared between both a smart compression garment and the gold-standard, a surface electromyography (EMG) system during high-speed cycling in seven participants. The smart compression garment, based on force myography (FMG), comprised of integrated pressure sensors that were sandwiched between skin and garment, located on five thigh muscles. The muscle activity was assessed by means of crank cycle diagrams (polar plots) that displayed the muscle activity relative to the crank cycle. The fatigue was assessed by means of the median frequency of the power spectrum of the EMG signal; the fractal dimension (FD) of the EMG signal; and the FD of the pressure signal. The smart compression garment returned performance parameters (muscle activity and fatigue) comparable to the surface EMG. The major differences were that the EMG measured the electrical activity, whereas the pressure sensor measured the mechanical activity. As such, there was a phase shift between electrical and mechanical signals, with the electrical signals preceding the mechanical counterparts in most cases. This is specifically pronounced in high-speed cycling. The fatigue trend over the duration of the cycling exercise was clearly reflected in the fatigue parameters (FDs and median frequency) obtained from pressure and EMG signals. The fatigue parameter of the pressure signal (FD) showed a higher time dependency ( R 2 = 0.84) compared to the EMG signal. This reflects that the pressure signal puts more emphasis on the fatigue as a function of time rather than on the origin of fatigue (e.g., peripheral or central fatigue). In light of the high-speed activity results, caution should be exerted when using data obtained from EMG for biomechanical models. In contrast to EMG data, activity data obtained from FMG are considered more appropriate and accurate as an input for biomechanical modeling as they truly reflect the mechanical muscle

  14. Muscle Performance Investigated With a Novel Smart Compression Garment Based on Pressure Sensor Force Myography and Its Validation Against EMG

    Directory of Open Access Journals (Sweden)

    Aaron Belbasis

    2018-04-01

    Full Text Available Muscle activity and fatigue performance parameters were obtained and compared between both a smart compression garment and the gold-standard, a surface electromyography (EMG system during high-speed cycling in seven participants. The smart compression garment, based on force myography (FMG, comprised of integrated pressure sensors that were sandwiched between skin and garment, located on five thigh muscles. The muscle activity was assessed by means of crank cycle diagrams (polar plots that displayed the muscle activity relative to the crank cycle. The fatigue was assessed by means of the median frequency of the power spectrum of the EMG signal; the fractal dimension (FD of the EMG signal; and the FD of the pressure signal. The smart compression garment returned performance parameters (muscle activity and fatigue comparable to the surface EMG. The major differences were that the EMG measured the electrical activity, whereas the pressure sensor measured the mechanical activity. As such, there was a phase shift between electrical and mechanical signals, with the electrical signals preceding the mechanical counterparts in most cases. This is specifically pronounced in high-speed cycling. The fatigue trend over the duration of the cycling exercise was clearly reflected in the fatigue parameters (FDs and median frequency obtained from pressure and EMG signals. The fatigue parameter of the pressure signal (FD showed a higher time dependency (R2 = 0.84 compared to the EMG signal. This reflects that the pressure signal puts more emphasis on the fatigue as a function of time rather than on the origin of fatigue (e.g., peripheral or central fatigue. In light of the high-speed activity results, caution should be exerted when using data obtained from EMG for biomechanical models. In contrast to EMG data, activity data obtained from FMG are considered more appropriate and accurate as an input for biomechanical modeling as they truly reflect the mechanical

  15. An investigation into UV light exposure as an experimental model for artificial aging on tensile strength and force delivery of elastomeric chain.

    Science.gov (United States)

    Wahab, Siti Waznah; Bister, Dirk; Sherriff, Martyn

    2014-02-01

    This study investigated the effect of ultraviolet type A light (UVA) exposure on the tensile properties of elastomeric chain. UVA light exposure was used as model for artificial aging, simulating prolonged storage of elastomeric chain. Tensile strength (n = 60) was measured after exposing Ormco, Forestadent and 3M chains to UVA light for 0, 2, 3, and 4 weeks. Force decay was measured (n = 60) using chain exposed for 5, 10, and 14 days. The chains were subsequently stretched at a constant distance and the resulting forces measured at 0, 1, 24 hours and 7, 14, 21, and 28 days. This test simulated a clinical scenario of pre-stretching and subsequent shortening of elastomeric chain. Tensile strength had statistically significant difference and was directly related to the duration of ultraviolet (UV) light exposure. Forestadent chain, which had the second highest value for the 'as received' product, showed the most consistent values over time with the lowest degradation. Ormco showed the lowest values for 'as received' as well as after UV exposure; 3M chain had the highest loss of tensile strength. Force decay was also significantly different. UV light exposure of 10 days or more appears to mark a 'watershed' between products: 3M had most survivors, Forestadent chain had some survivors, depending on the time the chain was stretched for. None of the Ormco product survived UV light exposure for more than 5 days. UVA light exposure may be used as a model for artificial aging as it reduces force delivery and tensile strength of exposed chains.

  16. Preliminary Assessment/Site Investigation: Tooele Army Depot, Utah. Volume 1. North Area and Facilities at Hill Air Force Base

    Science.gov (United States)

    1988-12-12

    and by James M. Montgomery (JMM) Inc., (1987) were typically yellowish brown to grayish orange with varying amounts of pink , red, black, yellow or...investigation. The following findings were presented in the report. " The grondwater floy velocity was calculated to range from 6 x 10 to 1 x 10- cm/second...U ol ti -f s - -~ - 0 F.X I I I4 I I I4 I 1 0 0-1 of TNT contamination (e.g., pink soils) was observed. However, during an onsite visit performed by

  17. Numerical investigation on the influence of surface tension and viscous force on the bubble dynamics with a CLSVOF method

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhiying; Li, Yikai; Huang, Biao; Gao, Deming [Beijing Institute of Technology, Beijing (China)

    2016-06-15

    We numerically investigated the rising of bubbles in a quiescent liquid layer. The numerical simulation is performed by solving the incompressible, multiphase Navier-Stokes equations via computational code in axisymmetric coordinates using a Coupled level-set and volume-of-fluid (CLSVOF) method. The numerical results show that the CLSVOF method with a novel algebraic relation between F and f for axisymmetric two-phase flows not only can predict the bubble surface accurately, but also overcome the deficiency in preserving volume conservation. The effects of the Reynolds number Re and the Bond number Bo on the bubble deformation and its motion are investigated. The results show that with the increasing of Re (10 < Re < 150), the bubble shape transfers from oblate ellipsoidal cap to toroidal when Bo = 116. With the increasing of Bo (10 < Bo < 700), the bubble shape transfers from oblate ellipsoidal to toroidal when Re = 30. Although the toroidal bubble shapes are reached in these two cases, the transition modes are different. For the case Bo = 116, the bubble front is pierced by an upward jet from the rear of the bubble. While for the case Re = 30, the rear of the bubble is pierced by a downward jet from the front part.

  18. Numerical investigation of double diffusive buoyancy forces induced natural convection in a cavity partially heated and cooled from sidewalls

    Directory of Open Access Journals (Sweden)

    Rasoul Nikbakhti

    2016-03-01

    Full Text Available This paper deals with a numerical investigation of double-diffusive natural convective heat and mass transfer in a cavity filled with Newtonian fluid. The active parts of two vertical walls of the cavity are maintained at fixed but different temperatures and concentrations, while the other two walls, as well as inactive areas of the sidewalls, are considered to be adiabatic and impermeable to mass transfer. The length of the thermally active part equals half of the height. The non-dimensional forms of governing transport equations that describe double-diffusive natural convection for two-dimensional incompressible flow are functions of temperature or energy, concentration, vorticity, and stream-function. The coupled differential equations are discretized via FDM (Finite Difference Method. The Successive-Over-Relaxation (SOR method is used in the solution of the stream function equation. The analysis has been done for an enclosure with different aspect ratios ranging from 0.5 to 11 for three different combinations of partially active sections. The results are presented graphically in terms of streamlines, isotherms and isoconcentrations. In addition, the heat and mass transfer rate in the cavity is measured in terms of the average Nusselt and Sherwood numbers for various parameters including thermal Grashof number, Lewis number, buoyancy ratio and aspect ratio. It is revealed that the placement order of partially thermally active walls and the buoyancy ratio influence significantly the flow pattern and the corresponding heat and mass transfer performance in the cavity.

  19. Investigation of forced and total degradation products of amlodipine besylate by liquid chromatography and liquid chromatography-mass spectrometry

    Directory of Open Access Journals (Sweden)

    Stoiljković Zora Ž.

    2014-01-01

    Full Text Available An isocratic, reversed-phase liquid chromatographic method was applied for the investigation of the degradation products of amlodipine besylate under the stressed conditions in solution. Amlodipine besylate stock solutions were subjected to acid and alkali hydrolysis, chemical oxidation and photodegradation as well as to the electrochemical degradation by cyclic voltammetry in 0.05 mol/L NaHCO3 on gold electrode. The total degradation of amlodipine besylate was achieved in 5 mol/L NaOH at 80°C for 6 h and the compound with molecular formula C15H16NOCl was identified as a main degradation product. Under acidic (5 mol/L HCl at 80°C for 6 h stress conditions 75.2% of amlodipine besylate degradation was recorded. Oxidative degradation in the solution of 3% H2O2-methanol 80:20 at 80°C for 6 h showed that amlodipine besylate degraded to 80.1%. After 14 days of expose in photostability chamber amlodipine besylate solution showed degradation of 32.2%. In electrochemical degradation after 9 hours of cyclization the beginning of amlodipine oxidation was shifted for 200 mV to more negative potentials, with the degradation of 66.5%. Mass spectrometry analysis confirmed the presence of dehydro amlodipine derivate with molecular formula C20H23N2O5Cl in oxidative and acidic conditions while in electrochemical degradation was detected in traces. [Projekat Ministarsva nauke Republike Srbije, br. 172013

  20. Investigating the Influence of Micro-Arc Oxide Coating on Rigidity and Strength of Long Force Elements of Spacecraft

    Directory of Open Access Journals (Sweden)

    V. K. Shatalov

    2014-01-01

    Full Text Available Outboard elements (arms, towers are widely used in spacecraft structure for setting-out of a payload; their high stiffness-weight ratio provides an opportunity to decrease the mass. The deployment unit is considered as an example of outboard structure. Its strength beams work under special conditions in operation. At the transportation stage beams are under considerable vibration loads. Therefore for increasing the natural resonance frequency it is rational to increase their rigidity. Using the micro-arc oxide coating suggests itself because the modulus of elasticity of the micro-arc oxide coating is more than that of the aluminium alloy. The beams suffer considerable bending load at the step of deploying; therefore the aluminium alloy with the micro-arc oxide coating must have suitable loading capacity, in addition to increased rigidity.Influence of micro-arc oxide coating on the rigidity and strength of tubes f rom aluminium alloy is investigated. It is determined that forming the micro-arc oxide coating on thin-walled tubes with a ratio of the coating area to the cross-section area of more than 25% is the most rational. In this case the rigidity of composite material considerably exceeds the rigidity of the aluminium alloy of the same cross-section while the redistribution of stresses in the surface coating of heterogeneous elasticity cross-section doesn’t cause the sudden increase of stresses. Also forming an attainable thickness of the micro-arc oxide coating on the surface of tube from aluminium alloy will be rational solution because the increase of attainable thickness of the microarc oxide coating provides an opportunity to form it on thick-walled tubes saving an acceptable, in the context of the strength, ratio of the coating area to the overall cross-section area.Micro-arc oxidation is an advanced method to form the wear resistant, resistant to corrosion, heat-shielding and electrically insulating coatings, but depending on the

  1. Experimental and Numerical Investigation of Forced Convection Heat Transfer in Heat Sink with Rectangular Plates at Varying Inclinations on Vertical Base

    Science.gov (United States)

    Patil, Harshal Bhauso; Dingare, Sunil Vishnu

    2018-03-01

    Heat exchange upgrade is a vital territory of research area. Utilization of reasonable systems can bring about noteworthy specialized points of interest coming about reserve funds of cost. Rectangular plates are viewed as best balance arrangement utilized for heat exchange improvement. This gives an enlargement strategy to heat exchange with beginning of limit layer and vortex development. To assess and look at the rate of heat exchange enhancement by rectangular plate fins with differing inclinations (0°-30°-60°), shifting Re and heat supply under forced convection are the principle destinations of this study. The study is done by fluctuating introductions of fins with various inclinations, input heat supply and Re under forced convection. The coefficient of heat transfer increments observed with the expansion in air speed for all the examined designs. The coefficient of the heat transfer is discovered higher at the edge of introduction of fins at 30° for inline arrangement and 0° for staggered arrangement. Looking at both the arrangements, it is discovered that the heat transfer coefficient in 0° fin staggered arrangement is about 17% higher than 30° inline arrangement and 76% higher than the vertical plate fin. For plate fin heat sink, boundary layer formation and growth results in decrease of the coefficient of heat transfer in forced convection. This issue is overcome by accommodating some rectangular fins on the plate fin. It brings about increment of heat transfer coefficient of the RPFHS under the states of trial factors. As indicated by past research, it is discovered that examination of the plate fin heat sink with various sorts of fins for horizontal orientation is done yet but this investigation expects to discover the upgrade of transfer coefficient of plate fin heat sink for its vertical position with rectangular plates at different inclinations under the shifting scopes of heat input supply, fin arrangements and Reynolds number (Re).

  2. Numerical investigation on lateral migration and lift force of single bubble in simple shear flow in low viscosity fluid using volume of fluid method

    International Nuclear Information System (INIS)

    Zhongchun, Li; Xiaoming, Song; Shengyao, Jiang; Jiyang, Yu

    2014-01-01

    Highlights: • A VOF simulation of bubble in low viscosity fluid was conducted. • Lift force in different viscosity fluid had different lateral migration characteristics. • Bubble with different size migrated to different direction. • Shear stress triggered the bubble deformation process and the bubble deformation came along with the oscillation behaviors. - Abstract: Two phase flow systems have been widely used in industrial engineering. Phase distribution characteristics are vital to the safety operation and optimization design of two phase flow systems. Lift force has been known as perpendicular to the bubbles’ moving direction, which is one of the mechanisms of interfacial momentum transfer. While most widely used lift force correlations, such as the correlation of Tomiyama et al. (2002), were obtained by experimentally tracking single bubble trajectories in high viscosity glycerol–water mixture, the applicability of these models into low viscosity fluid, such as water in nuclear engineering system, needs to be further evaluated. In the present paper, bubble in low viscosity fluid in shear flow was investigated in a full 3D numerical simulation and the volume of fluid (VOF) method was applied to capture the interface. The fluid parameter: fluid viscosity, bubble parameter: diameter and external flow parameters: shear stress magnitude and liquid velocity were examined. Comparing with bubble in high viscosity shear flow and bubble in low viscosity still flow, relative large bubble in low viscosity shear flow keep an oscillation way towards the moving wall and experienced a shape deformation process. The oscillation amplitude increased as the viscosity of fluid decreased. Small bubble migrated to the static wall in a line with larger migration velocity than that in high viscosity fluid and no deformation occurred. The shear stress triggered the oscillation behaviors while it had no direct influence with the behavior. The liquid velocity had no effect on

  3. Design of Phase I Combination Trials: Recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee

    Science.gov (United States)

    Paller, Channing J.; Bradbury, Penelope A.; Ivy, S. Percy; Seymour, Lesley; LoRusso, Patricia M.; Baker, Laurence; Rubinstein, Larry; Huang, Erich; Collyar, Deborah; Groshen, Susan; Reeves, Steven; Ellis, Lee M.; Sargent, Daniel J.; Rosner, Gary L.; LeBlanc, Michael L.; Ratain, Mark J.

    2014-01-01

    Anticancer drugs are combined in an effort to treat a heterogeneous tumor or to maximize the pharmacodynamic effect. The development of combination regimens, while desirable, poses unique challenges. These include the selection of agents for combination therapy that may lead to improved efficacy while maintaining acceptable toxicity, the design of clinical trials that provide informative results for individual agents and combinations, and logistical and regulatory challenges. The phase 1 trial is often the initial step in the clinical evaluation of a combination regimen. In view of the importance of combination regimens and the challenges associated with developing them, the Clinical Trial Design (CTD) Task Force of the National Cancer Institute (NCI) Investigational Drug Steering Committee developed a set of recommendations for the phase 1 development of a combination regimen. The first two recommendations focus on the scientific rationale and development plans for the combination regimen; subsequent recommendations encompass clinical design aspects. The CTD Task Force recommends that selection of the proposed regimens be based on a biological or pharmacological rationale supported by clinical and/or robust and validated preclinical evidence, and accompanied by a plan for subsequent development of the combination. The design of the phase 1 clinical trial should take into consideration the potential pharmacokinetic and pharmacodynamic interactions as well as overlapping toxicity. Depending on the specific hypothesized interaction, the primary endpoint may be dose optimization, pharmacokinetics, and/or pharmacodynamic (i.e., biomarker). PMID:25125258

  4. Subatomic forces

    International Nuclear Information System (INIS)

    Sutton, C.

    1989-01-01

    Inside the atom, particles interact through two forces which are never felt in the everyday world. But they may hold the key to the Universe. These ideas on subatomic forces are discussed with respect to the strong force, the electromagnetic force and the electroweak force. (author)

  5. In-situ investigation of crack propagation in {gamma}-TiAl alloys using atomic force, focus ion beam and scanning electron microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Iqbal, Farasat; Goeken, Mathias [Lehrstuhl Allgemeine Werkstoffeigenschaften, Friedrich-Alexander-Universitaet Erlangen-Nuernberg (Germany); Pyczak, Florian [GKSS Research Centre Geesthacht, Geesthacht (Germany)

    2009-07-01

    The present study is focused on crack propagation mechanism in Ti-45Al-1Cr and Ti-45Al-5Nb alloys with lamellar microstructure. Atomic force microscopy (AFM) is a versatile technique to study the crack propagation in-situ. AFM was employed to investigate the local deformations near the crack tip. Scanning electron microscopy (SEM) supplements the in-situ observations and was used to get a basic understanding of the crack propagation path over larger distances.A focused ion beam (FIB) was used to investigate the structures and deformation traces underneath the surface. It is concluded that the {gamma}/{alpha}2 interfaces act as favorable sites for new interfacial crack nucleation and also for interlamellar crack propagation. Nucleation of new cracks was often preceded by the interaction of deformation twins with interfaces and also by strong shear band activity in the {gamma}-TiAl lamellae visible as significant surface topography in AFM.Mostly the underneath crack path follows the {gamma}/{alpha}2 interface similar to the situation observed at the surface. The local misorientation measured with electron backscattered diffraction (EBSD) shows {gamma}-lamellae as the region of high deformation as compare to neighboring {alpha}2 -lamellae around the crack tip and its surroundings.

  6. Corrosive effects of fluoride on titanium: investigation by X-ray photoelectron spectroscopy, atomic force microscopy, and human epithelial cell culturing.

    Science.gov (United States)

    Stájer, Anette; Ungvári, Krisztina; Pelsoczi, István K; Polyánka, Hilda; Oszkó, Albert; Mihalik, Erzsébet; Rakonczay, Zoltán; Radnai, Márta; Kemény, Lajos; Fazekas, András; Turzó, Kinga

    2008-11-01

    High fluoride (F(-)) concentrations and acidic pH impair the corrosion resistance of titanium (Ti). Effects of F(-)-containing caries-preventive prophylactic rinses, and gels on Ti were investigated by X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM). Human epithelial cell attachment and proliferation were investigated by dimethylthiazol-diphenyl tetrazolium bromide (MTT) and protein content assays. Aqueous 1% NaF solution (3800 ppm F(-), pH 4.5) or high (12,500 ppm) F(-) content gel (pH 4.8) strongly corroded the surface and modified its composition. XPS revealed formation of a strongly bound F(-)-containing complex (Na(2)TiF(6)). AFM indicated an increase in roughness (R(a)) of the surfaces: 10-fold for the NaF solution and smaller for the gel or a mouthwash (250 ppm F(-), pH 4.4). MTT revealed that cell attachment was significantly increased by the gel, but was not disturbed by either the mouthwash or the NaF. Cell proliferation determined by MTT decreased significantly only for the NaF-treated samples; protein content assay experiments showed no such effect. This study indicates that epithelial cell culturing results can depend on the method used, and the adverse effects of a high F(-) concentration and low pH should be considered when prophylactic gels are applied by patients with Ti implants or other dental devices.

  7. Three-nucleon forces

    International Nuclear Information System (INIS)

    Sauer, P.U.

    2014-01-01

    In this paper, the role of three-nucleon forces in ab initio calculations of nuclear systems is investigated. The difference between genuine and induced many-nucleon forces is emphasized. Induced forces arise in the process of solving the nuclear many-body problem as technical intermediaries toward calculationally converged results. Genuine forces make up the Hamiltonian. They represent the chosen underlying dynamics. The hierarchy of contributions arising from genuine two-, three- and many-nucleon forces is discussed. Signals for the need of the inclusion of genuine three-nucleon forces are studied in nuclear systems, technically best under control, especially in three-nucleon and four-nucleon systems. Genuine three-nucleon forces are important for details in the description of some observables. Their contributions to observables are small on the scale set by two-nucleon forces. (author)

  8. Nano-scale Biophysical and Structural Investigations on Intact and Neuropathic Nerve Fibers by Simultaneous Combination of Atomic Force and Confocal Microscopy

    Directory of Open Access Journals (Sweden)

    Gonzalo Rosso

    2017-08-01

    Full Text Available The links between neuropathies of the peripheral nervous system (PNS, including Charcot-Marie-Tooth1A and hereditary neuropathy with liability to pressure palsies, and impaired biomechanical and structural integrity of PNS nerves remain poorly understood despite the medical urgency. Here, we present a protocol describing simultaneous structural and biomechanical integrity investigations on isolated nerve fibers, the building blocks of nerves. Nerve fibers are prepared from nerves harvested from wild-type and exemplary PNS neuropathy mouse models. The basic principle of the designed experimental approach is based on the simultaneous combination of atomic force microscopy (AFM and confocal microscopy. AFM is used to visualize the surface structure of nerve fibers at nano-scale resolution. The simultaneous combination of AFM and confocal microscopy is used to perform biomechanical, structural, and functional integrity measurements at nano- to micro-scale. Isolation of sciatic nerves and subsequent teasing of nerve fibers take ~45 min. Teased fibers can be maintained at 37°C in a culture medium and kept viable for up to 6 h allowing considerable time for all measurements which require 3–4 h. The approach is designed to be widely applicable for nerve fibers from mice of any PNS neuropathy. It can be extended to human nerve biopsies.

  9. Effects of Tumor Necrosis Factor-α on Morphology and Mechanical Properties of HCT116 Human Colon Cancer Cells Investigated by Atomic Force Microscopy.

    Science.gov (United States)

    Liu, Huiqing; Wang, Nan; Zhang, Zhe; Wang, Hongda; Du, Jun; Tang, Jilin

    2017-01-01

    Chronic inflammation orchestrates the tumor microenvironment and is strongly associated with cancer. Tumor necrosis factor- α (TNF α ) is involved in tumor invasion and metastasis by inducing epithelial to mesenchymal transition (EMT). This process is defined by the loss of epithelial characteristics and gain of mesenchymal traits. The mechanisms of TNF α -induced EMT in cancer cells have been well studied. However, mechanical properties have not yet been probed. In this work, atomic force microscopy (AFM) was applied to investigate the morphology and mechanical properties of EMT in HCT116 human colon cancer cells. A remarkable morphological change from cobblestone shape to spindle-like morphology was observed. In parallel, AFM images showed that the cellular cytoskeleton was rearranged from a cortical to a stress-fiber pattern. Moreover, cell stiffness measurements indicated that Young's modulus of cells gradually reduced from 1 to 3 days with TNF α -treatment, but it has an apparent increase after 4 days of treatment compared with that for 3 days. Additionally, Young's modulus of the cells treated with TNF α for 4 days is slightly larger than that for 1 or 2 days, but still less than that of the untreated cells. Our work contributes to a better understanding of colorectal cancer metastasis induced by inflammation.

  10. Effects of Tumor Necrosis Factor-α on Morphology and Mechanical Properties of HCT116 Human Colon Cancer Cells Investigated by Atomic Force Microscopy

    Directory of Open Access Journals (Sweden)

    Huiqing Liu

    2017-01-01

    Full Text Available Chronic inflammation orchestrates the tumor microenvironment and is strongly associated with cancer. Tumor necrosis factor-α (TNFα is involved in tumor invasion and metastasis by inducing epithelial to mesenchymal transition (EMT. This process is defined by the loss of epithelial characteristics and gain of mesenchymal traits. The mechanisms of TNFα-induced EMT in cancer cells have been well studied. However, mechanical properties have not yet been probed. In this work, atomic force microscopy (AFM was applied to investigate the morphology and mechanical properties of EMT in HCT116 human colon cancer cells. A remarkable morphological change from cobblestone shape to spindle-like morphology was observed. In parallel, AFM images showed that the cellular cytoskeleton was rearranged from a cortical to a stress-fiber pattern. Moreover, cell stiffness measurements indicated that Young’s modulus of cells gradually reduced from 1 to 3 days with TNFα-treatment, but it has an apparent increase after 4 days of treatment compared with that for 3 days. Additionally, Young’s modulus of the cells treated with TNFα for 4 days is slightly larger than that for 1 or 2 days, but still less than that of the untreated cells. Our work contributes to a better understanding of colorectal cancer metastasis induced by inflammation.

  11. Geological investigations and hydrogeologic model development in support of DoD and DOE environmental programs on Kirtland Air Force Base, New Mexico, U.S.A

    International Nuclear Information System (INIS)

    Gibson, J.D.; Pratt, G.; Davidson, H.; DeWitt, C.; Hitchcock, C.; Kelson, K.; Noller, J.; Sawyer, T.; Thomas, E.

    1994-01-01

    This paper presents results of preliminary geologic site characterization and hydrogeologic conceptual model development for the 250-km 2 Kirtland Air Force Base (KAFB) and associated lands in central New Mexico. The research, development, and other operational activities of the Department of Defense (DoD) and Department of Energy (DOE) on KAFB over the last 50 years have resulted in diverse hazardous, radioactive, and mixed-waste environmental concerns. Because multiple federal, state, and local agencies are responsible for administrating the involved lands and because of the nature of many U.S. environmental regulations, individual contaminated and potentially contaminated DoD and DOE environmental restoration (ER) sites on KAFB are commonly handled as distinct entities with little consideration for the cumulative environmental and health risk from all sites. A site-wide characterization program has been undertaken at Sandia National Laboratories/New Mexico (SNL/NM), under the auspices of the DOE, to construct a conceptual hydrogeologic model for the base. This conceptual model serves as the basis for placing each ER site into a broader context for evaluating background (i.e., non-contaminated) conditions and for modeling of possible contaminant pathways and travel-times. Regional and local hydrogeologic investigations from KAFB can be used as models for characterizing and evaluating other sites around the world where combined civilian and military environmental programs must work together to resolve environmental problems that may present health risks to workers and the general public

  12. Hydrothermal Atomic Force Microscopy Investigation of Barite Growth: Role of Spectator Ions in Elementary Step Edge Growth Kinetics and Hillock Morphology [Supporting Information Only

    Energy Technology Data Exchange (ETDEWEB)

    Jindra, Sarah A. [Wright State Univ., Dayton, OH (United States); Bertagni, Angela L. [Wright State Univ., Dayton, OH (United States); Bracco, Jacquelyn N. [Wright State Univ., Dayton, OH (United States); Argonne National Lab. (ANL), Argonne, IL (United States); Higgins, Steven R. [Wright State Univ., Dayton, OH (United States)

    2017-09-25

    Here, to better understand the role of spectator ions in barite growth, the kinetics of step edge growth on barite (001) surfaces were studied under various salt solutions. Hydrothermal atomic force microscopy (HAFM) was used to investigate the effect of background electrolytes (NaCl, NaBr, and NaNO3) as a function of saturation index and ionic strength (I) on barite growth sourced at dislocations at 108 °C. Results demonstrate that hillock morphology is affected by I, as well as type of anion, where the prevalence of steps aligned on the [010] direction is highest under Cl. There is a modest increase in kinetic coefficient of 55–130% with a 10-fold increase in I for each salt. In comparing the kinetic coefficients of the salts at low ionic strength (0.01 M), there is a moderate difference, suggesting that the anion may play a role in barium attachment.

  13. Hydrostatic force sensor

    International Nuclear Information System (INIS)

    Evans, M.S.; Stoughton, R.S.; Kazerooni, H.

    1994-08-01

    This paper presents a theoretical and experimental investigation of a new kind of force sensor which detects forces by measuring an induced pressure change in a material of large Poisson's ratio. In this investigation we develop mathematical expressions for the sensor's sensitivity and bandwidth, and show that its sensitivity can be much larger and its bandwidth is usually smaller than those of existing strain-gage-type sensors. This force sensor is well-suited for measuring large but slowly varying forces. It can be installed in a space smaller than that required by existing sensors

  14. Reactivity at the film/solution interface of ex situ prepared bismuth film electrodes: A scanning electrochemical microscopy (SECM) and atomic force microscopy (AFM) investigation

    International Nuclear Information System (INIS)

    Hocevar, Samo B.; Daniele, Salvatore; Bragato, Carlo; Ogorevc, Bozidar

    2007-01-01

    Bismuth film electrodes (BiFEs) prepared ex situ with and without complexing bromide ions in the modification solution were investigated using scanning electrochemical microscopy (SECM) and atomic force microscopy (AFM). A feedback mode of the SECM was employed to examine the conductivity and reactivity of a series of thin bismuth films deposited onto disk glassy carbon substrate electrodes (GCEs) of 3 mm in diameter. A platinum micro-electrode (φ = 25 μm) was used as the SECM tip, and current against tip/substrate distance was recorded in solutions containing either Ru(NH 3 ) 6 3+ or Fe(CN) 6 4- species as redox mediators. With both redox mediators positive feedback approach curves were recorded, which indicated that the bismuth film deposition protocol associated with the addition of bromide ions in the modification solution did not compromise the conductivity of the bismuth film in comparison with that prepared without bromide. However, at the former Bi film a slight kinetic hindering was observed in recycling Ru(NH 3 ) 6 3+ , suggesting a different surface potential. On the other hand, the approach curves recorded by using Fe(CN) 6 4- showed that both types of the aforementioned bismuth films exhibited local reactivity with the oxidised form of the redox mediator, and that bismuth film obtained with bromide ions exhibited slightly lower reactivity. The use of SECM in the scanning operation mode allowed us to ascertain that the bismuth deposits were uniformly distributed across the whole surface of the glassy carbon substrate electrode. Comparative AFM measurements corroborated the above findings and additionally revealed a denser growth of smaller bismuth crystals over the surface of the substrate electrode in the presence of bromide ions, while the crystals were bigger but sparser in the absence of bromide ions in the modification solution

  15. An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Volume I: 1997 Follow-up Examination Results

    National Research Council Canada - National Science Library

    Michalek, J

    2000-01-01

    .... A Comparison cohort comprised Air Force veterans who served in Southeast Asia during the same time period that the Ranch Hand unit was active and who were not involved with spraying herbicides...

  16. Labor Force

    Science.gov (United States)

    Occupational Outlook Quarterly, 2012

    2012-01-01

    The labor force is the number of people ages 16 or older who are either working or looking for work. It does not include active-duty military personnel or the institutionalized population, such as prison inmates. Determining the size of the labor force is a way of determining how big the economy can get. The size of the labor force depends on two…

  17. Investigation of the range of validity of the pairwise summation method applied to the calculation of the surface roughness correction to the van der Waals force

    Science.gov (United States)

    Gusso, André; Burnham, Nancy A.

    2016-09-01

    It has long been recognized that stochastic surface roughness can considerably change the van der Waals (vdW) force between interacting surfaces and particles. However, few analytical expressions for the vdW force between rough surfaces have been presented in the literature. Because they have been derived using perturbative methods or the proximity force approximation the expressions are valid when the roughness correction is small and for a limited range of roughness parameters and surface separation. In this work, a nonperturbative approach, the effective density method (EDM) is proposed to circumvent some of these limitations. The method simplifies the calculations of the roughness correction based on pairwise summation (PWS), and allows us to derive simple expressions for the vdW force and energy between two semispaces covered with stochastic rough surfaces. Because the range of applicability of PWS and, therefore, of our results, are not known a priori, we compare the predictions based on the EDM with those based on the multilayer effective medium model, whose range of validity can be defined more properly and which is valid when the roughness correction is comparatively large. We conclude that the PWS can be used for roughness characterized by a correlation length of the order of its rms amplitude, when this amplitude is of the order of or smaller than a few nanometers, and only for typically insulating materials such as silicon dioxide, silicon nitride, diamond, and certain glasses, polymers and ceramics. The results are relevant for the correct modeling of systems where the vdW force can play a significant role such as micro and nanodevices, for the calculation of the tip-sample force in atomic force microscopy, and in problems involving adhesion.

  18. Collision-dominated dust sheaths and voids - observations in micro-gravity experiments and numerical investigation of the force balance relations

    International Nuclear Information System (INIS)

    Tsytovich, V N; Morfill, G; Konopka, U; Thomas, H

    2003-01-01

    Numerical solutions of stationary force balance equations are used to investigate the possible dust configurations (dust structures) in complex plasmas between two floating potential plane electrodes. The distance between electrodes is assumed to be larger than the ion-neutral mean free path and the hydrodynamic description is used. It includes the known forces operating in this limit, the ionization source and the dust charge variations. The stationary balance equations are solved both in the case of the presence of one-size dust grains and for the case of a mixture of grains with two different sizes. Recent micro-gravity experiments with single-size dust grains and two-different-size dust grains show the formation of a system of dust sheaths and dust voids between the two plane electrodes. The observed configurations of dust structures depend strongly on the gas pressure and the degree of ionization used. The numerical investigations are able to show the necessary conditions for the types of structure to be created and give their size. The size of the structures observed is larger than the ion-neutral mean free path and is of the order of magnitude of that obtained numerically. The numerical investigations give details of the spatial distributions, the dust particles, the electron/ion densities, the ion drift velocity and dust charges inside and outside different dust structures. These details have not yet been investigated experimentally and can indicate directions for further experimental work to be performed. The single-dust-sheath structure with single-size dust particles surrounded by dust free regions (dust wall-voids) and floating potential electrodes is computed. Such a structure was observed recently and the computational results are in agreement with observations. It is shown that more often a dust void in the centre is observed. It is found that a dust void in the centre region between two electrodes is formed if the ionization rate is larger than the

  19. Dispersion Forces

    CERN Document Server

    Buhmann, Stefan Yoshi

    2012-01-01

    In this book, a modern unified theory of dispersion forces on atoms and bodies is presented which covers a broad range of advanced aspects and scenarios. Macroscopic quantum electrodynamics is shown to provide a powerful framework for dispersion forces which allows for discussing general properties like their non-additivity and the relation between microscopic and macroscopic interactions. It is demonstrated how the general results can be used to obtain dispersion forces on atoms in the presence of bodies of various shapes and materials. Starting with a brief recapitulation of volume I, this volume II deals especially with bodies of irregular shapes, universal scaling laws, dynamical forces on excited atoms, enhanced forces in cavity quantum electrodynamics, non-equilibrium forces in thermal environments and quantum friction. The book gives both the specialist and those new to the field a thorough overview over recent results in the field. It provides a toolbox for studying dispersion forces in various contex...

  20. Determination of the friction coefficient via the force autocorrelation function. A molecular dynamics investigation for a dense Lennard-Jones fluid

    International Nuclear Information System (INIS)

    Vogelsang, R.; Hoheisel, C.

    1987-01-01

    For a large region of dense fluid states of a Lennard-Jones system, they have calculated the friction coefficient by the force autocorrelation function of a Brownian-type particle by molecular dynamics (MD). The time integral over the force autocorrelation function showed an interesting behavior and the expected plateau value when the mass of the Brownian particle was chosen to be about a factor of 100 larger than the mass of the fluid particle. Sufficient agreement was found for the friction coefficient calculated by this way and that obtained by calculations of the self-diffusion coefficient using the common relation between these coefficients. Furthermore, a modified friction coefficient was determined by integration of the force autocorrelation function up to the first maximum. This coefficient can successfully be used to derive a reasonable soft part of the friction coefficient necessary for the Rice-Allnatt approximation for the shear velocity and simple liquids

  1. Photo-assisted Kelvin probe force microscopy investigation of three dimensional GaN structures with various crystal facets, doping types, and wavelengths of illumination

    Science.gov (United States)

    Ali Deeb, Manal; Ledig, Johannes; Wei, Jiandong; Wang, Xue; Wehmann, Hergo-Heinrich; Waag, Andreas

    2017-08-01

    Three dimensional GaN structures with different crystal facets and doping types have been investigated employing the surface photo-voltage (SPV) method to monitor illumination-induced surface charge behavior using Kelvin probe force microscopy. Various photon energies near and below the GaN bandgap were used to modify the generation of electron-hole pairs and their motion under the influence of the electric field near the GaN surface. Fast and slow processes for Ga-polar c-planes on both Si-doped n-type as well as Mg-doped p-type GaN truncated pyramid micro-structures were found and their origin is discussed. The immediate positive (for n-type) and negative (for p-type) SPV response dominates at band-to-band and near-bandgap excitation, while only the slow process is present at sub-bandgap excitation. The SPV behavior for the semi-polar facets of the p-type GaN truncated pyramids has a similar characteristic to that on its c-plane, which indicates that it has a comparable band bending and no strong influence of the polarity-induced charges is detectable. The SPV behavior of the non-polar m-facets of the Si-doped n-type part of a transferred GaN column is similar to that of a clean c-plane GaN surface during illumination. However, the SPV is smaller in magnitude, which is attributed to intrinsic surface states of m-plane surfaces and their influence on the band bending. The SPV behavior of the non-polar m-facet of the slightly Mg-doped part of this GaN column is found to behave differently. Compared to c- and r-facets of p-type surfaces of GaN-light-emitting diode micro-structures, the m-plane is more chemically stable.

  2. An experimental investigation into the deployment of 3-D, finned wing and shape memory alloy vortex generators in a forced air convection heat pipe fin stack

    International Nuclear Information System (INIS)

    Aris, M.S.; McGlen, R.; Owen, I.; Sutcliffe, C.J.

    2011-01-01

    Forced air convection heat pipe cooling systems play an essential role in the thermal management of electronic and power electronic devices such as microprocessors and IGBT's (Integrated Gate Bipolar Transistors). With increasing heat dissipation from these devices, novel methods of improving the thermal performance of fin stacks attached to the heat pipe condenser section are required. The current work investigates the use of a wing type surface protrusions in the form of 3-D delta wing tabs adhered to the fin surface, thin wings punched-out of the fin material and TiNi shape memory alloy delta wings which changed their angles of attack based on the fin surface temperature. The longitudinal vortices generated from the wing designs induce secondary mixing of the cooler free stream air entering the fin stack with the warmer fluid close to the fin surfaces. The change in angle of the attack of the active delta wings provide heat transfer enhancement while managing flow pressure losses across the fin stack. A heat transfer enhancement of 37% compared to a plain fin stack was obtained from the 3-D tabs in a staggered arrangement. The punched-out delta wings in the staggered and inline arrangements provided enhancements of 30% and 26% respectively. Enhancements from the active delta wings were lower at 16%. However, as these devices reduce the pressure drop through the fin stack by approximately 19% in the de-activate position, over the activated position, a reduction in fan operating cost may be achieved for systems operating with inlet air temperatures below the maximum inlet temperature specification for the device. CFD analysis was also carried out to provide additional detail of the local heat transfer enhancement effects. The CFD results corresponded well with previously published reports and were consistent with the experimental findings. - Highlights: → Heat transfer enhancements of heat pipe fin stacks was successfully achieved using fixed and active delta

  3. [Environmental investigation of ground water contamination at Wright-Patterson Air Force Base, Ohio]. Volume 3, Appendix A, Draft standard operating procedures and elements: Sampling and Analysis Plan (SAP): Phase 1, Task 4, Field Investigation, Draft

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-01

    This report presents information concerning field procedures employed during the monitoring, well construction, well purging, sampling, and well logging at the Wright-Patterson Air Force Base. Activities were conducted in an effort to evaluate ground water contamination.

  4. Theoretical Investigation of Hydrogen Adsorption and Dissociation on Iron and Iron Carbide Surfaces Using the ReaxFF Reactive Force Field Method

    Energy Technology Data Exchange (ETDEWEB)

    Zou, Chenyu; van Duin, Adri C.T.; Sorescu, Dan C.

    2012-06-01

    We have developed a ReaxFF reactive force field to describe hydrogen adsorption and dissociation on iron and iron carbide surfaces relevant for simulation of Fischer–Tropsch (FT) synthesis on iron catalysts. This force field enables large system (>>1000 atoms) simulations of hydrogen related reactions with iron. The ReaxFF force field parameters are trained against a substantial amount of structural and energetic data including the equations of state and heats of formation of iron and iron carbide related materials, as well as hydrogen interaction with iron surfaces and different phases of bulk iron. We have validated the accuracy and applicability of ReaxFF force field by carrying out molecular dynamics simulations of hydrogen adsorption, dissociation and recombination on iron and iron carbide surfaces. The barriers and reaction energies for molecular dissociation on these two types of surfaces have been compared and the effect of subsurface carbon on hydrogen interaction with iron surface is evaluated. We found that existence of carbon atoms at subsurface iron sites tends to increase the hydrogen dissociation energy barrier on the surface, and also makes the corresponding hydrogen dissociative state relatively more stable compared to that on bare iron. These properties of iron carbide will affect the dissociation rate of H{sub 2} and will retain more surface hydride species, thus influencing the dynamics of the FT synthesis process.

  5. An Investigation of Air Force Communities of Practice: A Descriptive Study of Evolution Through Assessment of People, Process, and Technology Capabilities

    National Research Council Canada - National Science Library

    May, Jason

    2003-01-01

    ... (Gongla and Rizzuto, 2001). A primary goal of AFMC/DRW, AFMC Electronic Learning (eLearning) Knowledge Management Integrated Project Team, and the office of the Air Force Chief Information Officer is to increase CoP participation and effectiveness...

  6. A Cross-Sectional Investigation of the Effects of Regional Labor Market Conditions on the Reenlistment Decisions of Air Force Enlistees

    Science.gov (United States)

    1991-09-01

    Baldwin, Robert H. and Thomas V. Daula. "Army Recruit Attrition and Force Manning Costs: Methodology and Analysis," Research in Labor Economics , ed. Ronald...Methodological Issues and a Proposed Specification," Research in Labor Economics , ed. Ronald Ehrenberg, 7:339-363 (1985b). Baldwin, Robert H. et al. "Military...Manpower Research: An Introduction," Research in Labor Economics , ed. Ronald Ehrenberg, L:257-260 (1985). Dalton, Dan R. et al. "Turnover Overstated: The

  7. EXPERIMENTAL INVESTIGATION OF THE EFFECT OF MACHINIG PARAMETERS OVER CUTTING FORCE AND SURFACE ROUGHNESS IN THE MACHINABILITY OF AA5052 ALLOY

    Directory of Open Access Journals (Sweden)

    Hasan GÖKKAYA

    2006-03-01

    Full Text Available In this study, the effects of different cutting and feed rates over average surface roughness and main cutting force during the machinability of AA5052 aluminum alloy with uncoated cemented carbide insert were evaluated. In the experiments, stable depth of cut (1.5 mm, four different cutting speeds (200, 300, 400, 500 m/min and five different feed rates (0.10, 0.15, 0.20, 0.25, 0.30 mm/rev were used. Based on cutting and feed rates, the lowest main cutting force was obtained as 113 in 500 m/min cutting speed and 0.10 mm/rev feed rate and the highest cutting force was obtained as 332 N in 200 m/min cutting speed and 0.30 mm/rev feed rate. The lowest average surface roughness was obtained as 0.95 µm in 200 m/min cutting speed and 0.10 mm/rev feed rate and the highest average surface roughness was obtained as 6.65 µm in 300 m/min cutting speed and 0.30 mm/rev feed rate.

  8. Different forces

    CERN Multimedia

    1982-01-01

    The different forces, together with a pictorial analogy of how the exchange of particles works. The table lists the relative strength of the couplings, the quanta associated with the force fields and the bodies or phenomena in which they have a dominant role.

  9. Labor Force

    Science.gov (United States)

    Occupational Outlook Quarterly, 2010

    2010-01-01

    The labor force is the number of people aged 16 or older who are either working or looking for work. It does not include active-duty military personnel or institutionalized people, such as prison inmates. Quantifying this total supply of labor is a way of determining how big the economy can get. Labor force participation rates vary significantly…

  10. Experimental investigation of the effect of an electric field on heat transfers at boiling point for a high-resistivity water in forced convection

    International Nuclear Information System (INIS)

    Morin, Henri; Verdier, Jacques

    1964-10-01

    The enhancement of heat exchanges with boiling water in forced convection in an annular duct is studied when applying an electric field between the two walls of the duct. At the local boiling and at saturation temperature, for a water resistivity comprised between 0.5 and 1 M Ω cm, with fields on the cylindrical interior surface of the canal comprised between 4 and 8 kV/cm, significant enhancements of the exchanged heat fluxes are noticed, 2.5 to 10 time superior to exchanges without electric field. When heating, heat fluxes may be increased from two to three times [fr

  11. The molecular-scale arrangement and mechanical strength of phospholipid/cholesterol mixed bilayers investigated by frequency modulation atomic force microscopy in liquid

    International Nuclear Information System (INIS)

    Asakawa, Hitoshi; Fukuma, Takeshi

    2009-01-01

    Cholesterols play key roles in controlling molecular fluidity in a biological membrane, yet little is known about their molecular-scale arrangements in real space. In this study, we have directly imaged lipid-cholesterol complexes in a model biological membrane consisting of dipalmitoylphosphatidylcholine (DPPC) and cholesterols by frequency modulation atomic force microscopy (FM-AFM) in phosphate buffer solution. FM-AFM images of a DPPC/cholesterol bilayer in the liquid-ordered phase showed higher energy dissipation values compared to those measured on a nanoscale DPPC domain in the gel phase, reflecting the increased molecular fluidity due to the insertion of cholesterols. Molecular-resolution FM-AFM images of a DPPC/cholesterol bilayer revealed the existence of a rhombic molecular arrangement (lattice constants: a = 0.46 nm, b = 0.71 nm) consisting of alternating rows of DPPC and cholesterols as well as the increased defect density and reduced molecular ordering. The mechanical strength of a DPPC/cholesterol bilayer was quantitatively evaluated by measuring a loading force required to penetrate the membrane with an AFM tip. The result revealed the significant decrease of mechanical strength upon insertion of cholesterols. Based on the molecular-scale arrangement found in this study, we propose a model to explain the reduced mechanical strength in relation to the formation of lipid-ion networks.

  12. The molecular-scale arrangement and mechanical strength of phospholipid/cholesterol mixed bilayers investigated by frequency modulation atomic force microscopy in liquid

    Energy Technology Data Exchange (ETDEWEB)

    Asakawa, Hitoshi; Fukuma, Takeshi [Frontier Science Organization, Kanazawa University, Kakuma-machi, 920-1192 Kanazawa (Japan)], E-mail: hi_asa@staff.kanazawa-u.ac.jp, E-mail: fukuma@staff.kanazawa-u.ac.jp

    2009-07-01

    Cholesterols play key roles in controlling molecular fluidity in a biological membrane, yet little is known about their molecular-scale arrangements in real space. In this study, we have directly imaged lipid-cholesterol complexes in a model biological membrane consisting of dipalmitoylphosphatidylcholine (DPPC) and cholesterols by frequency modulation atomic force microscopy (FM-AFM) in phosphate buffer solution. FM-AFM images of a DPPC/cholesterol bilayer in the liquid-ordered phase showed higher energy dissipation values compared to those measured on a nanoscale DPPC domain in the gel phase, reflecting the increased molecular fluidity due to the insertion of cholesterols. Molecular-resolution FM-AFM images of a DPPC/cholesterol bilayer revealed the existence of a rhombic molecular arrangement (lattice constants: a = 0.46 nm, b = 0.71 nm) consisting of alternating rows of DPPC and cholesterols as well as the increased defect density and reduced molecular ordering. The mechanical strength of a DPPC/cholesterol bilayer was quantitatively evaluated by measuring a loading force required to penetrate the membrane with an AFM tip. The result revealed the significant decrease of mechanical strength upon insertion of cholesterols. Based on the molecular-scale arrangement found in this study, we propose a model to explain the reduced mechanical strength in relation to the formation of lipid-ion networks.

  13. Local current-voltage behaviors of preferentially and randomly textured Cu(In,Ga)Se2 thin films investigated by conductive atomic force microscopy

    International Nuclear Information System (INIS)

    Shin, R.H.; Jo, W.; Kim, D.W.; Yun, Jae Ho; Ahn, S.

    2011-01-01

    Electrical transport properties on polycrystalline Cu(In,Ga)Se 2 (CIGS) (Ga/(In+Ga) ∼35%) thin films were examined by conductive atomic force microscopy. The CIGS thin films with a (112) preferential or random texture were deposited on Mo-coated glass substrates. Triangular pyramidal grain growths were observed in the CIGS thin films preferentially textured to the (112) planes. Current maps of the CIGS surface were acquired with a zero or non-zero external voltage bias. The contrast of the images on the grain boundaries and intragrains displayed the conduction path in the materials. Local current-voltage measurements were performed to evaluate the charge conduction properties of the CIGS thin films. (orig.)

  14. A direct investigation of photocharge transfer across monomolecular layer between C{sub 60} and CdS quantum dots by photoassisted conductive atomic force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Xiaohong; Liu, He; Zhang, Xingtang; Cheng, Gang; Wang, Shujie; Du, Zuliang, E-mail: zld@henu.edu.cn [Key Laboratory for Special Functional Materials, Collaborative Innovation Center of Nano Functional Materials and Applications, Henan University, Kaifeng, 475004, PR. China (China)

    2016-04-15

    The composite assembly of C{sub 60} and CdS Quantum Dots (QDs) on ITO substrate was prepared by Langmuir-Blodgett (LB) technique using arachic acid (AA), stearic acid (SA) and octadecanyl amine (OA) as additives. Photoassisted conductive atomic force microscopy was used to make point contact current-voltage (I-V) measurements on both the CdS QDs and the composite assembly of C{sub 60}/CdS. The result make it clear that the CdS, C{sub 60}/CdS assemblies deposited on ITO substrate showed linear characteristics and the current increased largely under illumination comparing with that in the dark. The coherent, nonresonant tunneling mechanism was used to explain the current occurrence. It is considered that the photoinduced carriers CdS QDs tunneled through alkyl chains increased the current rapidly.

  15. The effect of multiple autoclave cycles on the surface of rotary nickel-titanium endodontic files: An in vitro atomic force microscopy investigation.

    Science.gov (United States)

    Nair, Ashish Shashikant; Tilakchand, Mahima; Naik, Balaram Damodar

    2015-01-01

    To observe and study the effect of multiple autoclave sterilization cycles, on the surface of nickel-titanium (NiTi) files. The file used for this study was the Mtwo file (VDW) and ProTaper (Dentsply). The apical 5 mm of the files were attached to a silicon wafer and subjected to autoclave cycles under standardized conditions. They were scanned with an AFM after 1, 5, and 10 cycles. The unsterilized files were used as control, before start of the study. Three vertical topographic parameters namely maximum height (MH), root mean square (RMS) of surface roughness, and arithmetic mean roughness (AMR)were measured with the atomic force microscope (AFM). Analysis of variance along with Tukey's test was used to test the differences. The vertical topographic parameters were higher for both the files, right after the first cycle, when compared with the control (P autoclave cycles, a fact that should be kept in mind during their reuse.

  16. Local current-voltage behaviors of preferentially and randomly textured Cu(In,Ga)Se{sub 2} thin films investigated by conductive atomic force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Shin, R.H.; Jo, W. [Ewha Womans University, Department of Physics, Seoul (Korea, Republic of); Kim, D.W. [Ewha Womans University, Department of Physics, Seoul (Korea, Republic of); Ewha Womans University, Department of Chemistry and Nanosciences, Seoul (Korea, Republic of); Yun, Jae Ho; Ahn, S. [Korea Institute of Energy Research, Daejeon (Korea, Republic of)

    2011-09-15

    Electrical transport properties on polycrystalline Cu(In,Ga)Se{sub 2} (CIGS) (Ga/(In+Ga) {approx}35%) thin films were examined by conductive atomic force microscopy. The CIGS thin films with a (112) preferential or random texture were deposited on Mo-coated glass substrates. Triangular pyramidal grain growths were observed in the CIGS thin films preferentially textured to the (112) planes. Current maps of the CIGS surface were acquired with a zero or non-zero external voltage bias. The contrast of the images on the grain boundaries and intragrains displayed the conduction path in the materials. Local current-voltage measurements were performed to evaluate the charge conduction properties of the CIGS thin films. (orig.)

  17. A direct investigation of photocharge transfer across monomolecular layer between C60 and CdS quantum dots by photoassisted conductive atomic force microscopy

    Directory of Open Access Journals (Sweden)

    Xiaohong Jiang

    2016-04-01

    Full Text Available The composite assembly of C60 and CdS Quantum Dots (QDs on ITO substrate was prepared by Langmuir-Blodgett (LB technique using arachic acid (AA, stearic acid (SA and octadecanyl amine (OA as additives. Photoassisted conductive atomic force microscopy was used to make point contact current-voltage (I-V measurements on both the CdS QDs and the composite assembly of C60/CdS. The result make it clear that the CdS, C60/CdS assemblies deposited on ITO substrate showed linear characteristics and the current increased largely under illumination comparing with that in the dark. The coherent, nonresonant tunneling mechanism was used to explain the current occurrence. It is considered that the photoinduced carriers CdS QDs tunneled through alkyl chains increased the current rapidly.

  18. Membrane Disruption Mechanism of a Prion Peptide (106-126) Investigated by Atomic Force Microscopy, Raman and Electron Paramagnetic Resonance Spectroscopy.

    Science.gov (United States)

    Pan, Jianjun; Sahoo, Prasana K; Dalzini, Annalisa; Hayati, Zahra; Aryal, Chinta M; Teng, Peng; Cai, Jianfeng; Rodriguez Gutierrez, Humberto; Song, Likai

    2017-05-18

    A fragment of the human prion protein spanning residues 106-126 (PrP106-126) recapitulates many essential properties of the disease-causing protein such as amyloidogenicity and cytotoxicity. PrP106-126 has an amphipathic characteristic that resembles many antimicrobial peptides (AMPs). Therefore, the toxic effect of PrP106-126 could arise from a direct association of monomeric peptides with the membrane matrix. Several experimental approaches are employed to scrutinize the impacts of monomeric PrP106-126 on model lipid membranes. Porous defects in planar bilayers are observed by using solution atomic force microscopy. Adding cholesterol does not impede defect formation. A force spectroscopy experiment shows that PrP106-126 reduces Young's modulus of planar lipid bilayers. We use Raman microspectroscopy to study the effect of PrP106-126 on lipid atomic vibrational dynamics. For phosphatidylcholine lipids, PrP106-126 disorders the intrachain conformation, while the interchain interaction is not altered; for phosphatidylethanolamine lipids, PrP106-126 increases the interchain interaction, while the intrachain conformational order remains similar. We explain the observed differences by considering different modes of peptide insertion. Finally, electron paramagnetic resonance spectroscopy shows that PrP106-126 progressively decreases the orientational order of lipid acyl chains in magnetically aligned bicelles. Together, our experimental data support the proposition that monomeric PrP106-126 can disrupt lipid membranes by using similar mechanisms found in AMPs.

  19. A preliminary investigation of short-term cytokine  expression in gingival crevicular fluid secondary to high-level orthodontic forces and the associated root resorption: case series analytical study.

    Science.gov (United States)

    Ahuja, Rajiv; Almuzian, Moahmmed; Khan, Alamgir; Pascovici, Dana; Dalci, Oyku; Darendeliler, M Ali

    2017-12-01

    Orthodontically induced iatrogenic root resorption (OIIRR) is an unavoidable inflammatory process. Several factors claimed to be related to the severity of OIIRR. Orthodontic forces cause micro-trauma to the periodontal ligament and activate a cascade of cellular events associated with local periodontal inflammation. The purpose of this split-mouth study were (1) to investigate the changes in cytokine profile in the gingival crevicular fluid (GCF) secondary to heavy orthodontic forces and (2) to compare the cytokine expression between participants showing high and low root resorption. Eight participants requiring maxillary first premolar extractions involved in this study. The teeth on the tested side (TS) received 225 g of controlled buccal tipping force for 28 days, while the contralateral teeth act as a control (CS). GCF was collected from both TS and CS teeth at 0 h (prior to application of force) and 3 h, 1 day, 3 days, 7 days and 28 days after the application of force, and analysed with multiplex bead immunoassay to determine the cytokine levels. Statistically significant temporal increase was found in the TS teeth for tumour necrosis factor alpha (TNF-α) at 3 h and 28 days (p = 0.01). Interleukin 7 (IL-7) significantly peaked at the 28th day. Comparing cytokine profile for participants with high and low root resorption (>0.35 and root resorption cases (p root resorption which craters on mesial, distal surfaces and middle third region were significant in the TS teeth (p resorptive cytokine) increased significantly secondary to a high-level of orthodontic force application. Significantly high levels of granulocyte macrophage colony-stimulating factor (anti-resorptive cytokine) were detected in mild root resorption cases secondary to high-level orthodontic force application. A future long-term randomised clinical trial with larger sample taking in consideration gender, age and growth pattern distribution would be recommended.

  20. A preliminary investigation of short-term cytokine  expression in gingival crevicular fluid secondary to high-level orthodontic forces and the associated root resorption: case series analytical study

    Directory of Open Access Journals (Sweden)

    Rajiv Ahuja

    2017-08-01

    Full Text Available Abstract Background Orthodontically induced iatrogenic root resorption (OIIRR is an unavoidable inflammatory process. Several factors claimed to be related to the severity of OIIRR. Orthodontic forces cause micro-trauma to the periodontal ligament and activate a cascade of cellular events associated with local periodontal inflammation. The purpose of this split-mouth study were (1 to investigate the changes in cytokine profile in the gingival crevicular fluid (GCF secondary to heavy orthodontic forces and (2 to compare the cytokine expression between participants showing high and low root resorption. Methods Eight participants requiring maxillary first premolar extractions involved in this study. The teeth on the tested side (TS received 225 g of controlled buccal tipping force for 28 days, while the contralateral teeth act as a control (CS. GCF was collected from both TS and CS teeth at 0 h (prior to application of force and 3 h, 1 day, 3 days, 7 days and 28 days after the application of force, and analysed with multiplex bead immunoassay to determine the cytokine levels. Results Statistically significant temporal increase was found in the TS teeth for tumour necrosis factor alpha (TNF-α at 3 h and 28 days (p = 0.01. Interleukin 7 (IL-7 significantly peaked at the 28th day. Comparing cytokine profile for participants with high and low root resorption (>0.35 and <0.15 mm3, respectively, the levels of GM-CSF was significantly greater in low root resorption cases (p < 0.05. The amounts of root resorption which craters on mesial, distal surfaces and middle third region were significant in the TS teeth (p < 0.05. Conclusions IL-7 and TNF-α (pro-resorptive cytokine increased significantly secondary to a high-level of orthodontic force application. Significantly high levels of granulocyte macrophage colony-stimulating factor (anti-resorptive cytokine were detected in mild root resorption cases secondary to high

  1. Force Myography for Monitoring Grasping in Individuals with Stroke with Mild to Moderate Upper-Extremity Impairments: A Preliminary Investigation in a Controlled Environment

    Directory of Open Access Journals (Sweden)

    Gautam P. Sadarangani

    2017-07-01

    Full Text Available There is increasing research interest in technologies that can detect grasping, to encourage functional use of the hand as part of daily living, and thus promote upper-extremity motor recovery in individuals with stroke. Force myography (FMG has been shown to be effective for providing biofeedback to improve fine motor function in structured rehabilitation settings, involving isolated repetitions of a single grasp type, elicited at a predictable time, without upper-extremity movements. The use of FMG, with machine learning techniques, to detect and distinguish between grasping and no grasping, continues to be an active area of research, in healthy individuals. The feasibility of classifying FMG for grasp detection in populations with upper-extremity impairments, in the presence of upper-extremity movements, as would be expected in daily living, has yet to be established. We explore the feasibility of FMG for this application by establishing and comparing (1 FMG-based grasp detection accuracy and (2 the amount of training data necessary for accurate grasp classification, in individuals with stroke and healthy individuals. FMG data were collected using a flexible forearm band, embedded with six force-sensitive resistors (FSRs. Eight participants with stroke, with mild to moderate upper-extremity impairments, and eight healthy participants performed 20 repetitions of three tasks that involved reaching, grasping, and moving an object in different planes of movement. A validation sensor was placed on the object to label data as corresponding to a grasp or no grasp. Grasp detection performance was evaluated using linear and non-linear classifiers. The effect of training set size on classification accuracy was also determined. FMG-based grasp detection demonstrated high accuracy of 92.2% (σ = 3.5% for participants with stroke and 96.0% (σ = 1.6% for healthy volunteers using a support vector machine (SVM. The use of a training set that was 50

  2. Nuclear forces

    International Nuclear Information System (INIS)

    Holinde, K.

    1990-01-01

    In this paper the present status of the meson theory of nuclear forces is reviewed. After some introductory remarks about the relevance of the meson exchange concept in the era of QCD and the empirical features of the NN interaction, the exciting history of nuclear forces is briefly outlined. In the main part, the author gives the basic physical ideas and sketch the derivation of the one-boson-exchange model of the nuclear force, in the Feynman approach. Secondly we describe, in a qualitative way, various necessary extensions, leading to the Bonn model of the N interaction. Finally, points to some interesting pen questions connected with the extended quark structure of the hadrons, which are topics of current research activity

  3. Dynamics of Pseudomonas aeruginosa azurin and its Cys3Ser mutant at single crystal gold surfaces investigated by cyclic voltammetry and atomic force microscopy

    DEFF Research Database (Denmark)

    Friis, Esben P.; Andersen, Jens Enevold Thaulov; Madsen, Lars Lithen

    1997-01-01

    Cyclic voltammetry of Pseudomonas aeruginosa azurin on polycrystalline gold is reversible (E0=360mV vs she;50mM ammonium acetate) but the voltammetric signals decay with time constants of about 3x10-3 s-1. No signal is observed for monocrystalline Au(111). Cys3Ser azurin is electrochemically inac...... into the solution, recovering the free Au(111) surface. The cyclic voltammetry and AFM data are consistent with time dependent adsorption of the azurins on gold via the disulphide bridge (wild-type) or free thiol group (Cys3Ser mutant).......Cyclic voltammetry of Pseudomonas aeruginosa azurin on polycrystalline gold is reversible (E0=360mV vs she;50mM ammonium acetate) but the voltammetric signals decay with time constants of about 3x10-3 s-1. No signal is observed for monocrystalline Au(111). Cys3Ser azurin is electrochemically...... inactive on either type of gold electrode but shows a reversible although decaying peak (362mV, 50mM ammonium acetate; decay time constant ~ 2x10-3 s-1) on edge-plane pyrolytic graphite.Ex situ and in situ atomic force microscopy (AFM) of the azurins on Au(111) show initially arrays of protein structures...

  4. An investigation using atomic force microscopy nanoindentation of dental enamel demineralization as a function of undissociated acid concentration and differential buffer capacity

    International Nuclear Information System (INIS)

    Barbour, Michele E; Shellis, R Peter

    2007-01-01

    Acidic drinks and foodstuffs can demineralize dental hard tissues, leading to a pathological condition known as dental erosion, which is of increasing clinical concern. The first step in enamel dissolution is a demineralization of the outer few micrometres of tissue, which results in a softening of the structure. The primary determinant of dissolution rate is pH, but the concentration of undissociated acid, which is related to buffer capacity, also appears to be important. In this study, atomic force microscopy nanoindentation was used to measure the first initial demineralization (softening) induced within 1 min by exposure to solutions with a range of undissociated acid concentration and natural pH of 3.3 or with an undissociated acid concentration of 10 mmol l -1 and pH adjusted to 3.3. The results indicate that differential buffering capacity is a better determinant of softening than undissociated acid concentration. Under the conditions of these experiments, a buffer capacity of >3 mmol l -1 pH -1 does not have any further effect on dissolution rate. These results imply that differential buffering capacity should be used for preference over undissociated acid concentration or titratable acidity, which are more commonly employed in the literature

  5. Dissolution Processes at Step Edges of Calcite in Water Investigated by High-Speed Frequency Modulation Atomic Force Microscopy and Simulation.

    Science.gov (United States)

    Miyata, Kazuki; Tracey, John; Miyazawa, Keisuke; Haapasilta, Ville; Spijker, Peter; Kawagoe, Yuta; Foster, Adam S; Tsukamoto, Katsuo; Fukuma, Takeshi

    2017-07-12

    The microscopic understanding of the crystal growth and dissolution processes have been greatly advanced by the direct imaging of nanoscale step flows by atomic force microscopy (AFM), optical interferometry, and X-ray microscopy. However, one of the most fundamental events that govern their kinetics, namely, atomistic events at the step edges, have not been well understood. In this study, we have developed high-speed frequency modulation AFM (FM-AFM) and enabled true atomic-resolution imaging in liquid at ∼1 s/frame, which is ∼50 times faster than the conventional FM-AFM. With the developed AFM, we have directly imaged subnanometer-scale surface structures around the moving step edges of calcite during its dissolution in water. The obtained images reveal that the transition region with typical width of a few nanometers is formed along the step edges. Building upon insight in previous studies, our simulations suggest that the transition region is most likely to be a Ca(OH) 2 monolayer formed as an intermediate state in the dissolution process. On the basis of this finding, we improve our understanding of the atomistic dissolution model of calcite in water. These results open up a wide range of future applications of the high-speed FM-AFM to the studies on various dynamic processes at solid-liquid interfaces with true atomic resolution.

  6. An investigation using atomic force microscopy nanoindentation of dental enamel demineralization as a function of undissociated acid concentration and differential buffer capacity

    Science.gov (United States)

    Barbour, Michele E.; Shellis, R. Peter

    2007-02-01

    Acidic drinks and foodstuffs can demineralize dental hard tissues, leading to a pathological condition known as dental erosion, which is of increasing clinical concern. The first step in enamel dissolution is a demineralization of the outer few micrometres of tissue, which results in a softening of the structure. The primary determinant of dissolution rate is pH, but the concentration of undissociated acid, which is related to buffer capacity, also appears to be important. In this study, atomic force microscopy nanoindentation was used to measure the first initial demineralization (softening) induced within 1 min by exposure to solutions with a range of undissociated acid concentration and natural pH of 3.3 or with an undissociated acid concentration of 10 mmol l-1 and pH adjusted to 3.3. The results indicate that differential buffering capacity is a better determinant of softening than undissociated acid concentration. Under the conditions of these experiments, a buffer capacity of >3 mmol l-1 pH-1 does not have any further effect on dissolution rate. These results imply that differential buffering capacity should be used for preference over undissociated acid concentration or titratable acidity, which are more commonly employed in the literature.

  7. Phase transition behaviors of the supported DPPC bilayer investigated by sum frequency generation (SFG) vibrational spectroscopy and atomic force microscopy (AFM).

    Science.gov (United States)

    Wu, Heng-Liang; Tong, Yujin; Peng, Qiling; Li, Na; Ye, Shen

    2016-01-21

    The phase transition behaviors of a supported bilayer of dipalmitoylphosphatidyl-choline (DPPC) have been systematically evaluated by in situ sum frequency generation (SFG) vibrational spectroscopy and atomic force microscopy (AFM). By using an asymmetric bilayer composed of per-deuterated and per-protonated monolayers, i.e., DPPC-d75/DPPC and a symmetric bilayer of DPPC/DPPC, we were able to probe the molecular structural changes during the phase transition process of the lipid bilayer by SFG spectroscopy. It was found that the DPPC bilayer is sequentially melted from the top (adjacent to the solution) to bottom leaflet (adjacent to the substrate) over a wide temperature range. The conformational ordering of the supported bilayer does not decrease (even slightly increases) during the phase transition process. The conformational defects in the bilayer can be removed after the complete melting process. The phase transition enthalpy for the bottom leaflet was found to be approximately three times greater than that for the top leaflet, indicating a strong interaction of the lipids with the substrate. The present SFG and AFM observations revealed similar temperature dependent profiles. Based on these results, the temperature-induced structural changes in the supported lipid bilayer during its phase transition process are discussed in comparison with previous studies.

  8. Investigation of free fatty acid associated recombinant membrane receptor protein expression in HEK293 cells using Raman spectroscopy, calcium imaging, and atomic force microscopy.

    Science.gov (United States)

    Lin, Juqiang; Xu, Han; Wu, Yangzhe; Tang, Mingjie; McEwen, Gerald D; Liu, Pin; Hansen, Dane R; Gilbertson, Timothy A; Zhou, Anhong

    2013-02-05

    G-protein-coupled receptor 120 (GPR120) is a previously orphaned G-protein-coupled receptor that apparently functions as a sensor for dietary fat in the gustatory and digestive systems. In this study, a cDNA sequence encoding a doxycycline (Dox)-inducible mature peptide of GPR120 was inserted into an expression vector and transfected in HEK293 cells. We measured Raman spectra of single HEK293 cells as well as GPR120-expressing HEK293-GPR120 cells at a 48 h period following the additions of Dox at several concentrations. We found that the spectral intensity of HEK293-GPR120 cells is dependent upon the dose of Dox, which correlates with the accumulation of GPR120 protein in the cells. However, the amount of the fatty acid activated changes in intracellular calcium (Ca(2+)) as measured by ratiometric calcium imaging was not correlated with Dox concentration. Principal components analysis (PCA) of Raman spectra reveals that the spectra from different treatments of HEK293-GPR120 cells form distinct, completely separated clusters with the receiver operating characteristic (ROC) area of 1, while those spectra for the HEK293 cells form small overlap clusters with the ROC area of 0.836. It was also found that expression of GPR120 altered the physiochemical and biomechanical properties of the parental cell membrane surface, which was quantitated by atomic force microscopy (AFM). These findings demonstrate that the combination of Raman spectroscopy, calcium imaging, and AFM may provide new tools in noninvasive and quantitative monitoring of membrane receptor expression induced alterations in the biophysical and signaling properties of single living cells.

  9. Wind Forces on Container Ships

    DEFF Research Database (Denmark)

    Andersen, Ingrid Marie Vincent

    2012-01-01

    An investigation of the wind forces acting on a 9,000+ TEU container ship has been carried out through a series of wind tunnel tests. It was investigated how the wind forces depend on the container configuration on the deck using a 1:450 scale model and a series of appropriate container...... are presented as nondimensional coefficients. It is concluded, that the measured forces and moment depend on the container configuration on deck, and the results may provide a general idea of how the magnitude of the wind forces is affected by a given container stacking configuration on a similar container ship....

  10. Experimental and numerical investigation on heat transfer augmentation in a circular tube under forced convection with annular differential blockages/inserts

    Science.gov (United States)

    Waghole, D. R.

    2018-01-01

    Investigation on heat transfer by generating turbulence in the fluid stream inside the circular tube is an innovative area of research for researchers. Hence, many techniques are been investigated and adopted for enhancement of heat transfer rate to reduce the size and the cost of the heat exchanger/circular tube. In the present study the effect of differential solid ring inserts /turbulators on heat transfer, friction factor of heat exchanger/circular tube was evaluated through experimentally and numerically. The experiments were conducted in range of 3000 ≤Re≤ 6500 and annular blockages 0 ≤ɸ≤50 %. The heat transfer rate was higher for differential combination of inserts as compared to tube fitted with uniform inserts. The maximum heat transfer was obtained by the use of differential metal circular ring inserts/blockages. From this study, Nusselt number, friction factor and enhancement factor are found as 2.5-3.5 times, 12% - 50.5% and 155% - 195%, respectively with water. Finally new possible correlations for predicting heat transfer and friction factor in the flow of water through the circular tube with differential blockages/inserts are proposed.

  11. Numerical Investigation of Thermal Radiation and Viscous Effects on Entropy Generation in Forced Convection Blood Flow over an Axisymmetric Stretching Sheet

    Directory of Open Access Journals (Sweden)

    Mohammad Yaghoub Abdollahzadeh Jamalabadi

    2016-05-01

    Full Text Available Numerical and analytical investigation of the effects of thermal radiation and viscous heating on a convective flow of a non-Newtonian, incompressible fluid in an axisymmetric stretching sheet with constant temperature wall is performed. The power law model of the blood is used for the non-Newtonian model of the fluid and the Rosseland model for the thermal radiative heat transfer in an absorbing medium and viscous heating are considered as the heat sources. The non-dimensional governing equations are transformed to similarity form and solved numerically. A parameter study on entropy generation in medium is presented based on the Second Law of Thermodynamics by considering various parameters such as the thermal radiation parameter, the Brinkman number, Prandtl number, Eckert number.

  12. X-ray investigations of sulfur-containing fungicides. II. Intramolecular forces governing the conformation of four novel alpha-phenylazo- and alpha-phenylhydrazono-beta-ketosulfones.

    Science.gov (United States)

    Wolf , W M

    2001-02-01

    The crystal and molecular structures of four novel beta-ketosulfones, phenyl benzoyl(phenylhydrazono)methyl sulfone (I), phenyl benzoyl(4-nitrophenylhydrazono)methyl sulfone (II), (benzoyl)(phenyl)(phenylazo)methyl phenyl sulfone (III) and (benzoyl)(phenyl)(3-chlorophenylazo)methyl 4-tolyl sulfone (IV), have been investigated using X-ray analysis and density functional theory supplemented by ab initio Hartree-Fock calculations. The conformations of (I) and (II) are stabilized by strong intramolecular resonance-assisted hydrogen bonds formed between the sulfonyl and the alpha-hydrazono moieties. The following increase of a positive charge on the S atoms is compensated via pi-conjugation and stereoelectronic back-donation from the nearby beta-carbonyl group. Compounds (III) and (IV) adopt a strongly distorted propeller shape with pivotal tetrahedral C1 atoms. Distortion mostly follows from the approximate coplanarity of the alpha-azophenyl and alpha-phenyl moieties opposite each other. The main stereoelectronic interactions involve the donation of electron density from the alpha-azo N2 towards the sulfonyl S and the beta-carbonyl C2 atoms.

  13. Simulation of the Greenland Ice Sheet over two glacial–interglacial cycles: investigating a sub-ice-shelf melt parameterization and relative sea level forcing in an ice-sheet–ice-shelf model

    Directory of Open Access Journals (Sweden)

    S. L. Bradley

    2018-05-01

    Full Text Available Observational evidence, including offshore moraines and sediment cores, confirm that at the Last Glacial Maximum (LGM the Greenland ice sheet (GrIS expanded to a significantly larger spatial extent than seen at present, grounding into Baffin Bay and out onto the continental shelf break. Given this larger spatial extent and its close proximity to the neighbouring Laurentide Ice Sheet (LIS and Innuitian Ice Sheet (IIS, it is likely these ice sheets will have had a strong non-local influence on the spatial and temporal behaviour of the GrIS. Most previous paleo ice-sheet modelling simulations recreated an ice sheet that either did not extend out onto the continental shelf or utilized a simplified marine ice parameterization which did not fully include the effect of ice shelves or neglected the sensitivity of the GrIS to this non-local bedrock signal from the surrounding ice sheets. In this paper, we investigated the evolution of the GrIS over the two most recent glacial–interglacial cycles (240 ka BP to the present day using the ice-sheet–ice-shelf model IMAU-ICE. We investigated the solid earth influence of the LIS and IIS via an offline relative sea level (RSL forcing generated by a glacial isostatic adjustment (GIA model. The RSL forcing governed the spatial and temporal pattern of sub-ice-shelf melting via changes in the water depth below the ice shelves. In the ensemble of simulations, at the glacial maximums, the GrIS coalesced with the IIS to the north and expanded to the continental shelf break to the southwest but remained too restricted to the northeast. In terms of the global mean sea level contribution, at the Last Interglacial (LIG and LGM the ice sheet added 1.46 and −2.59 m, respectively. This LGM contribution by the GrIS is considerably higher (∼  1.26 m than most previous studies whereas the contribution to the LIG highstand is lower (∼  0.7 m. The spatial and temporal behaviour of the northern margin was

  14. Investigation of the dipole formation and growth behavior at In2O3|TiO2 heterojunctions using photoemission spectroscopy and atomic force microscopy

    Science.gov (United States)

    Schaefer, Michael; Halpegamage, Sandamali; Batzill, Matthias; Schlaf, Rudy

    2016-02-01

    This paper discusses the investigation of the dipole formation at In2O3|TiO2 heterojunctions depending on preparation conditions, i.e., cleaning methods. In2O3 films were deposited using atomic layer deposition (ALD) onto solvent and in situ cleaned anatase and rutile film substrates. The interface dipole strength and film thickness were evaluated by photoemission spectroscopy. Our results indicate the formation of a large intrinsic and film thickness dependent interface dipole that reaches its maximum strength at monolayer thick ALD films. In addition, it was observed that UV photoelectron spectroscopy measurements introduced UV induced surface hydroxylation, which resulted in dipole potentials of -0.70 eV and -0.50 eV on solvent cleaned anatase and rutile, respectively. The overlayers also introduced small amounts of band bending (˜0.10 eV) at the interfaces. Taking these effects into account, the total dipole strength at monolayer thick In2O3 films was determined to be -0.96 eV for solvent cleaned anatase and rutile and -0.81 eV for in situ cleaned rutile. The deposition of single ALD cycles on differently cleaned rutile substrates resulted in similar work function values, suggesting little influence of the sample preparation method prior to ALD deposition on the dipole formation. This was assigned to the fact that ALD oxides benefit from ambient water related contamination by integrating the molecules into the growing ALD layer. Highest initial growth was observed on solvent cleaned rutile, followed by in-situ cleaned rutile and solvent cleaned anatase. The In2O3 growth converged at 0.3 Å/c past the nucleation regime.

  15. Coriolis Force

    Science.gov (United States)

    Marciuc, Daly; Solschi, Viorel

    2017-04-01

    Understanding the Coriolis effect is essential for explaining the movement of air masses and ocean currents. The lesson we propose aims to familiarize students with the manifestation of the Coriolis effect. Students are guided to build, using the GeoGebra software, a simulation of the motion of a body, related to a rotating reference system. The mathematical expression of the Coriolis force is deduced, for particular cases, and the Foucault's pendulum is presented and explained. Students have the opportunity to deepen the subject, by developing materials related to topics such as: • Global Wind Pattern • Ocean Currents • Coriolis Effect in Long Range Shooting • Finding the latitude with a Foucault Pendulum

  16. Invisible force

    International Nuclear Information System (INIS)

    Panek, Richard

    2010-01-01

    Astronomers have compiled evidence that what we always thought of as the actual universe- all the planets, stars, galaxies and matter in space -represents a mere 4% of what's out there. The rest is dark: 23% is called dark matter, 73% dark energy. Scientists have ideas about what dark matter is, but hardly any understanding about dark energy. This has led to rethinking traditional physics and cosmology. Assuming the existence of dark matter and that the law of gravitation is universal, two teams of astrophysicists, from Lawrence Berkeley National Laboratory and the Australian National University, analysed the universe's growth and to their surprise both concluded that the universe expansion is not slowing but speeding up. If the dominant force of evolution isn't gravity what is it?

  17. Force Protection and Command Relationships: Who's Responsible

    National Research Council Canada - National Science Library

    Moller, James

    1998-01-01

    .... This monograph analyzes the joint force protection program by investigating the terms: command, chain of command, command relationship, and how these terms authorize and empower a commander to implement this program across the joint force...

  18. Globally Coupled Chaotic Maps with Constant Force

    International Nuclear Information System (INIS)

    Li Jinghui

    2008-01-01

    We investigate the motion of the globally coupled maps (logistic map) with a constant force. It is shown that the constant force can cause multi-synchronization for the globally coupled chaotic maps studied by us.

  19. Force-Time Entropy of Isometric Impulse.

    Science.gov (United States)

    Hsieh, Tsung-Yu; Newell, Karl M

    2016-01-01

    The relation between force and temporal variability in discrete impulse production has been viewed as independent (R. A. Schmidt, H. Zelaznik, B. Hawkins, J. S. Frank, & J. T. Quinn, 1979 ) or dependent on the rate of force (L. G. Carlton & K. M. Newell, 1993 ). Two experiments in an isometric single finger force task investigated the joint force-time entropy with (a) fixed time to peak force and different percentages of force level and (b) fixed percentage of force level and different times to peak force. The results showed that the peak force variability increased either with the increment of force level or through a shorter time to peak force that also reduced timing error variability. The peak force entropy and entropy of time to peak force increased on the respective dimension as the parameter conditions approached either maximum force or a minimum rate of force production. The findings show that force error and timing error are dependent but complementary when considered in the same framework with the joint force-time entropy at a minimum in the middle parameter range of discrete impulse.

  20. Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy

    Science.gov (United States)

    Neuman, Keir C.; Nagy, Attila

    2012-01-01

    Single-molecule force spectroscopy has emerged as a powerful tool to investigate the forces and motions associated with biological molecules and enzymatic activity. The most common force spectroscopy techniques are optical tweezers, magnetic tweezers and atomic force microscopy. These techniques are described and illustrated with examples highlighting current capabilities and limitations. PMID:18511917

  1. 12th Air Force > Home

    Science.gov (United States)

    Force AOR Travel Info News prevnext Slide show 76,410 pounds of food delivered to Haiti 12th Air Force the French Air Force, Colombian Air Force, Pakistan Air Force, Belgian Air Force, Brazilian Air Force

  2. Thermal creep force: analysis and application

    OpenAIRE

    Wolfe, David M.

    2016-01-01

    Approved for public release; distribution is unlimited The existence of two motive forces on a Crookes radiometer has complicated the investigation of either force independently. The thermal creep shear force, in particular, has been subject to differing interpretations of the direction in which it acts and its order of magnitude. A horizontal vane radiometer design is provided, which isolates the thermal creep shear force. The horizontal vane radiometer is explored through experiment, kin...

  3. Handbook of force transducers

    CERN Document Server

    Stefanescu, Dan Mihai

    2011-01-01

    Part I introduces the basic ""Principles and Methods of Force Measurement"" acording to a classification into a dozen of force transducers types: resistive, inductive, capacitive, piezoelectric, electromagnetic, electrodynamic, magnetoelastic, galvanomagnetic (Hall-effect), vibrating wires, (micro)resonators, acoustic and gyroscopic. Two special chapters refer to force balance techniques and to combined methods in force measurement. Part II discusses the ""(Strain Gauge) Force Transducers Components"", evolving from the classical force transducer to the digital / intelligent one, with the inco

  4. SU(6) symmetry and the quark forces

    International Nuclear Information System (INIS)

    Bartnik, E.A.; Namyslowski, J.M.

    1984-01-01

    The short distance forces between 3 valence quarks in the proton are investigated in perturbative QCD formulated on the light cone. These forces are the driving terms in the Brodsky-Lepage type evolution equation for the partially decomposed distribution amplitudes. The one-gluon exchange force, which is the lowest order force in the running coupling constant αsub(s) retains the SU(6) symmetry, while the αsub(s) 2 -order force, corresponding to one Coulomb gluon and one transverse gluon, breaks the SU(6) symmetry. The latter force contributes to the deviation from 1/2 of the d/u ratio for the proton, observed experimentally. In the kinematical domain of one fast quark, the αsub(s) 2 -order force gives the leading (1-x) 3 behaviour of the deep inelastic structure function F 2 (x), in contrast to the αsub(s)-order force, which gives (1-x) 5 , for xapprox.=1. (orig.)

  5. Capillary forces in tapping mode atomic force microscopy

    NARCIS (Netherlands)

    Zitzler, L.; Herminghaus, S.; Mugele, Friedrich Gunther

    2002-01-01

    We investigated the influence of the relative humidity on amplitude and phase of the cantilever oscillation while operating an atomic force microscope (AFM) in the tapping mode. If the free oscillation amplitude A0 exceeds a certain critical amplitude Ac, the amplitude- and phase-distance curves

  6. Force and Directional Force Modulation Effects on Accuracy and Variability in Low-Level Pinch Force Tracking.

    Science.gov (United States)

    Park, Sangsoo; Spirduso, Waneen; Eakin, Tim; Abraham, Lawrence

    2018-01-01

    The authors investigated how varying the required low-level forces and the direction of force change affect accuracy and variability of force production in a cyclic isometric pinch force tracking task. Eighteen healthy right-handed adult volunteers performed the tracking task over 3 different force ranges. Root mean square error and coefficient of variation were higher at lower force levels and during minimum reversals compared with maximum reversals. Overall, the thumb showed greater root mean square error and coefficient of variation scores than did the index finger during maximum reversals, but not during minimum reversals. The observed impaired performance during minimum reversals might originate from history-dependent mechanisms of force production and highly coupled 2-digit performance.

  7. Interfacial force measurements using atomic force microscopy

    NARCIS (Netherlands)

    Chu, L.

    2018-01-01

    Atomic Force Microscopy (AFM) can not only image the topography of surfaces at atomic resolution, but can also measure accurately the different interaction forces, like repulsive, adhesive and lateral existing between an AFM tip and the sample surface. Based on AFM, various extended techniques have

  8. Low frequency temperature forcing of chemical oscillations.

    Science.gov (United States)

    Novak, Jan; Thompson, Barnaby W; Wilson, Mark C T; Taylor, Annette F; Britton, Melanie M

    2011-07-14

    The low frequency forcing of chemical oscillations by temperature is investigated experimentally in the Belousov-Zhabotinsky (BZ) reaction and in simulations of the Oregonator model with Arrhenius temperature dependence of the rate constants. Forcing with temperature leads to modulation of the chemical frequency. The number of response cycles per forcing cycle is given by the ratio of the natural frequency to the forcing frequency and phase locking is only observed in simulations when this ratio is a whole number and the forcing amplitude is small. The global temperature forcing of flow-distributed oscillations in a tubular reactor is also investigated and synchronisation is observed in the variation of band position with the external signal, reflecting the periodic modulation of chemical oscillations by temperature.

  9. Forces in general relativity

    International Nuclear Information System (INIS)

    Ridgely, Charles T

    2010-01-01

    Many textbooks dealing with general relativity do not demonstrate the derivation of forces in enough detail. The analyses presented herein demonstrate straightforward methods for computing forces by way of general relativity. Covariant divergence of the stress-energy-momentum tensor is used to derive a general expression of the force experienced by an observer in general coordinates. The general force is then applied to the local co-moving coordinate system of a uniformly accelerating observer, leading to an expression of the inertial force experienced by the observer. Next, applying the general force in Schwarzschild coordinates is shown to lead to familiar expressions of the gravitational force. As a more complex demonstration, the general force is applied to an observer in Boyer-Lindquist coordinates near a rotating, Kerr black hole. It is then shown that when the angular momentum of the black hole goes to zero, the force on the observer reduces to the force on an observer held stationary in Schwarzschild coordinates. As a final consideration, the force on an observer moving in rotating coordinates is derived. Expressing the force in terms of Christoffel symbols in rotating coordinates leads to familiar expressions of the centrifugal and Coriolis forces on the observer. It is envisioned that the techniques presented herein will be most useful to graduate level students, as well as those undergraduate students having experience with general relativity and tensor analysis.

  10. Students' conceptions about force

    International Nuclear Information System (INIS)

    Soeguet, Oe.

    2005-01-01

    Students from a young age have developed in their own minds differing concepts of things such as all creatures having a soul. Also children see the environment and interpret what they see according to their own understanding and explanation. In particular, with regards to physics, things like light, heat, motion, structure of matter and energy are understood at the level of a child s comprehension. Most often the child s understanding varies quite differently from the actual true meaning. As a result the child is reluctant to accept any other explanation. In such situations the necessary difficulties must be tackled with care and caution pertinent to the individual. Studies at K.S.U University related to force and motion of various departments in the Faculty of Science and Letters have been investigated. After evaluations of all the findings a number of suggestions have been made to change student views and ideas

  11. Malaysia and forced migration

    Directory of Open Access Journals (Sweden)

    Arzura Idris

    2012-06-01

    Full Text Available This paper analyzes the phenomenon of “forced migration” in Malaysia. It examines the nature of forced migration, the challenges faced by Malaysia, the policy responses and their impact on the country and upon the forced migrants. It considers forced migration as an event hosting multifaceted issues related and relevant to forced migrants and suggests that Malaysia has been preoccupied with the issue of forced migration movements. This is largely seen in various responses invoked from Malaysia due to “south-south forced migration movements.” These responses are, however, inadequate in terms of commitment to the international refugee regime. While Malaysia did respond to economic and migration challenges, the paper asserts that such efforts are futile if she ignores issues critical to forced migrants.

  12. Labor Force Participation Rate

    Data.gov (United States)

    City and County of Durham, North Carolina — This thematic map presents the labor force participation rate of working-age people in the United States in 2010. The 2010 Labor Force Participation Rate shows the...

  13. RSOI: Force Deployment Bottleneck

    National Research Council Canada - National Science Library

    D'Amato, Mark

    1998-01-01

    .... This runs counter to the popular belief that strategic lift is the limiting constraint. The study begins by highlighting the genesis of the military's current force projection strategy and the resulting importance of rapid force deployments...

  14. Acoustic force spectroscopy

    NARCIS (Netherlands)

    Sitters, G.; Kamsma, D.; Thalhammer, G.; Ritsch-Marte, M.; Peterman, E.J.G.; Wuite, G.J.L.

    2015-01-01

    Force spectroscopy has become an indispensable tool to unravel the structural and mechanochemical properties of biomolecules. Here we extend the force spectroscopy toolbox with an acoustic manipulation device that can exert forces from subpiconewtons to hundreds of piconewtons on thousands of

  15. Crossflow force transducer

    International Nuclear Information System (INIS)

    Mulcahy, T.M.

    1982-05-01

    A force transducer for measuring lift and drag coefficients for a circular cylinder in turbulent water flow is presented. In addition to describing the actual design and construction of the strain-gauged force- ring based transducer, requirements for obtained valid fluid force test data are discussed, and pertinent flow test experience is related

  16. Forces in General Relativity

    Science.gov (United States)

    Ridgely, Charles T.

    2010-01-01

    Many textbooks dealing with general relativity do not demonstrate the derivation of forces in enough detail. The analyses presented herein demonstrate straightforward methods for computing forces by way of general relativity. Covariant divergence of the stress-energy-momentum tensor is used to derive a general expression of the force experienced…

  17. Air Force Senior Leaders

    Science.gov (United States)

    Force TV Radio Week in Photos About Us Air Force Senior Leaders SECAF CSAF CMSAF Biographies Adjunct Professors Senior Mentor Biographies Fact Sheets Commander's Call Topics CCT Archive CSAF Reading List 2017 Media Sites Site Registration Contact Us Search AF.mil: Home > About Us > Air Force Senior Leaders

  18. Forced draft wet cooling systems

    International Nuclear Information System (INIS)

    Daubert, A.; Caudron, L.; Viollet, P.L.

    1975-01-01

    The disposal of the heat released from a 1000MW power plant needs a natural draft tower of about 130m of diameter at the base, and 170m height, or a cooling system with a draft forced by about forty vans, a hundred meters in diameter, and thirty meters height. The plumes from atmospheric cooling systems form, in terms of fluid mechanics, hot jets in a cross current. They consist in complex flows that must be finely investigated with experimental and computer means. The study, currently being performed at the National Hydraulics Laboratory, shows that as far as the length and height of visible plumes are concerned, the comparison is favorable to some types of forced draft cooling system, for low and medium velocities, (below 5 or 6m/s at 10m height. Beyond these velocities, the forced draft sends the plume up to smaller heights, but the plume is generally more dilute [fr

  19. 32 CFR 632.4 - Deadly force.

    Science.gov (United States)

    2010-07-01

    ..., is substantially important to national security. (See paragraph (b) of this section.) (iii) Escape of... security or an essential national defense mission. (2) Substantially important to national security based... INVESTIGATIONS USE OF FORCE BY PERSONNEL ENGAGED IN LAW ENFORCEMENT AND SECURITY DUTIES § 632.4 Deadly force. (a...

  20. Lattice QCD simulation of meson exchange forces

    International Nuclear Information System (INIS)

    Richards, D.G.; Sinclair, D.K.; Sivers, D.

    1990-01-01

    We present the formalism for investigating the bar Qq bar Qq system in lattice QCD. This system serves as a model for describing exchange forces between heavy, static hadrons. We use this formalism to calculate the exchange potential from gauge configurations which incorporate the effects of dynamical quarks. Our data can be interpreted as giving preliminary results on the range of the nuclear force

  1. Investigations on sail force by full scale measurement and numerical calculation. Part 1. Steady sailing performance; Sail ryutairyoku ni kansuru jissen shiken to suchi keisan. 1. Teijo hanso seino

    Energy Technology Data Exchange (ETDEWEB)

    Masuyama, Y.; Fukasawa, T. [Kanazawa Institute of Technology, Ishikawa (Japan); Kitazaki, T. [DMW Corp., Tokyo (Japan)

    1997-06-01

    Sailing forces are measured with a 10.3m long full-scale sailing boat, equipped with a sail force dynamometer, CCD camera for sail shape measurement and an instrument for detecting sailing conditions of the hull, in order to obtain highly reliable performance data of a sailing yacht. The vortex lattice method is used for step-by-step numerical calculations, and the results are compared with the observed ones. The test results clearly show performance changing with slight changes in relative wind directions and sail shapes, which are not clearly obtained by the traditional wind tunnel tests. The calculated results, although deviating from the observed ones to some extent, well represent trends of performance changing with wind directions and sail shapes. In particular, changed performance caused by slight changes in draft at the main sail is clearly demonstrated. The numerical calculation is considered to be useful for searching for sail trim conditions. 17 refs., 18 figs., 1 tab.

  2. Quantum fictitious forces

    DEFF Research Database (Denmark)

    Bialynicki-Birula, I; Cirone, M.A.; Dahl, Jens Peder

    2002-01-01

    We present Heisenberg's equation of motion for the radial variable of a free non-relativistic particle in D dimensions. The resulting radial force consists of three contributions: (i) the quantum fictitious force which is either attractive or repulsive depending on the number of dimensions, (ii......) a singular quantum force located at the origin, and (iii) the centrifugal force associated with non-vanishing angular momentum. Moreover, we use Heisenberg's uncertainty relation to introduce a lower bound for the kinetic energy of an ensemble of neutral particles. This bound is quadratic in the number...... of atoms and can be traced back to the repulsive quantum fictitious potential. All three forces arise for a free particle: "Force without force"....

  3. modelingthe effect the effect of contact and seepage forces

    African Journals Online (AJOL)

    eobe

    This research work has investigated the contribution of contact force and seepage force to the ... e equilibrium model has deduced an expression for the safe hydraulic head during well ...... Plastic deformation of soils simulation using DEM,.

  4. Force Reflection Algorithms for Exoskeleton Controllers

    National Research Council Canada - National Science Library

    Bryfogle, Mark

    1991-01-01

    This research effort investigated the kinematics and dynamics of open chain, serial linkage mechanisms with specific emphasis placed upon the application of this linkage as a force reflecting exoskeleton mechanism...

  5. StringForce

    DEFF Research Database (Denmark)

    Barendregt, Wolmet; Börjesson, Peter; Eriksson, Eva

    2017-01-01

    In this paper, we present the forced collaborative interaction game StringForce. StringForce is developed for a special education context to support training of collaboration skills, using readily available technologies and avoiding the creation of a "mobile bubble". In order to play String......Force two or four physically collocated tablets are required. These tablets are connected to form one large shared game area. The game can only be played by collaborating. StringForce extends previous work, both technologically and regarding social-emotional training. We believe String......Force to be an interesting demo for the IDC community, as it intertwines several relevant research fields, such as mobile interaction and collaborative gaming in the special education context....

  6. Quantum anticentrifugal force

    International Nuclear Information System (INIS)

    Cirone, M.A.; Schleich, W.P.; Straub, F.; Rzazewski, K.; Wheeler, J.A.

    2002-01-01

    In a two-dimensional world, a free quantum particle of vanishing angular momentum experiences an attractive force. This force originates from a modification of the classical centrifugal force due to the wave nature of the particle. For positive energies the quantum anticentrifugal force manifests itself in a bunching of the nodes of the energy wave functions towards the origin. For negative energies this force is sufficient to create a bound state in a two-dimensional δ-function potential. In a counterintuitive way, the attractive force pushes the particle away from the location of the δ-function potential. As a consequence, the particle is localized in a band-shaped domain around the origin

  7. Relativistic Linear Restoring Force

    Science.gov (United States)

    Clark, D.; Franklin, J.; Mann, N.

    2012-01-01

    We consider two different forms for a relativistic version of a linear restoring force. The pair comes from taking Hooke's law to be the force appearing on the right-hand side of the relativistic expressions: d"p"/d"t" or d"p"/d["tau"]. Either formulation recovers Hooke's law in the non-relativistic limit. In addition to these two forces, we…

  8. Graphene cantilever under Casimir force

    Science.gov (United States)

    Derras-Chouk, Amel; Chudnovsky, Eugene M.; Garanin, Dmitry A.; Jaafar, Reem

    2018-05-01

    The stability of graphene cantilever under Casimir attraction to an underlying conductor is investigated. The dependence of the instability threshold on temperature and flexural rigidity is obtained. Analytical work is supplemented by numerical computation of the critical temperature above which the graphene cantilever irreversibly bends down and attaches to the conductor. The geometry of the attachment and exfoliation of the graphene sheet is discussed. It is argued that graphene cantilever can be an excellent tool for precision measurements of the Casimir force.

  9. Method for lateral force calibration in atomic force microscope using MEMS microforce sensor.

    Science.gov (United States)

    Dziekoński, Cezary; Dera, Wojciech; Jarząbek, Dariusz M

    2017-11-01

    In this paper we present a simple and direct method for the lateral force calibration constant determination. Our procedure does not require any knowledge about material or geometrical parameters of an investigated cantilever. We apply a commercially available microforce sensor with advanced electronics for direct measurement of the friction force applied by the cantilever's tip to a flat surface of the microforce sensor measuring beam. Due to the third law of dynamics, the friction force of the equal value tilts the AFM cantilever. Therefore, torsional (lateral force) signal is compared with the signal from the microforce sensor and the lateral force calibration constant is determined. The method is easy to perform and could be widely used for the lateral force calibration constant determination in many types of atomic force microscopes. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Force induced DNA melting

    International Nuclear Information System (INIS)

    Santosh, Mogurampelly; Maiti, Prabal K

    2009-01-01

    When pulled along the axis, double-strand DNA undergoes a large conformational change and elongates by roughly twice its initial contour length at a pulling force of about 70 pN. The transition to this highly overstretched form of DNA is very cooperative. Applying a force perpendicular to the DNA axis (unzipping), double-strand DNA can also be separated into two single-stranded DNA, this being a fundamental process in DNA replication. We study the DNA overstretching and unzipping transition using fully atomistic molecular dynamics (MD) simulations and argue that the conformational changes of double-strand DNA associated with either of the above mentioned processes can be viewed as force induced DNA melting. As the force at one end of the DNA is increased the DNA starts melting abruptly/smoothly above a critical force depending on the pulling direction. The critical force f m , at which DNA melts completely decreases as the temperature of the system is increased. The melting force in the case of unzipping is smaller compared to the melting force when the DNA is pulled along the helical axis. In the case of melting through unzipping, the double-strand separation has jumps which correspond to the different energy minima arising due to sequence of different base pairs. The fraction of Watson-Crick base pair hydrogen bond breaking as a function of force does not show smooth and continuous behavior and consists of plateaus followed by sharp jumps.

  11. Intermolecular and surface forces

    CERN Document Server

    Israelachvili, Jacob N

    2011-01-01

    This reference describes the role of various intermolecular and interparticle forces in determining the properties of simple systems such as gases, liquids and solids, with a special focus on more complex colloidal, polymeric and biological systems. The book provides a thorough foundation in theories and concepts of intermolecular forces, allowing researchers and students to recognize which forces are important in any particular system, as well as how to control these forces. This third edition is expanded into three sections and contains five new chapters over the previous edition.· starts fr

  12. RSOI: Force Deployment Bottleneck

    National Research Council Canada - National Science Library

    D'Amato, Mark

    1998-01-01

    This study uses The Theory Of Constraints (TOC) management methodology and recent military missions to show that RSOI operations are generally the limiting constraint to force deployment operations...

  13. Air Force Academy Homepage

    Science.gov (United States)

    Communications Focal Point Contracting Squadron Force Support Squadron Mortuary Affairs Logistics Readiness Squadron Cadet Logistics Deployment and Distribution Material Management Operations PM Equipment Lab

  14. Simulation of a force on force exercise

    International Nuclear Information System (INIS)

    Terhune, R.; Van Slyke, D.; Sheppard, T.; Brandrup, M.

    1988-01-01

    The Security Exercise Evaluation System (SEES) is under development for use in planning Force on Force exercises and as an aid in post-exercise evaluation. This study is part of the development cycle where the simulation results are compared to field data to provide guidance for further development of the model. SEES is an event-driven stochastic computer program simulating individual movement and combat within an urban terrain environment. The simulator models the physics of movement, line of sight, and weapon effects. It relies on the controllers to provide all knowledge of security tactics, which are entered by the controllers during the simulation using interactive color graphic workstations. They are able to develop, modify and implement plans promptly as the simulator maintains real time. This paper reports on how SEES will be used to develop an intrusion plan, test the security response tactics and develop observer logistics. A Force on Force field exercise will then be executed to follow the plan with observations recorded. An analysis is made by first comparing the plan and events of the simulation with the field exercise, modifying the simulation plan to match the actual field exercise, and then running the simulation to develop a distribution of possible outcomes

  15. Equilibrium capillary forces with atomic force microscopy

    NARCIS (Netherlands)

    Sprakel, J.H.B.; Besseling, N.A.M.; Leermakers, F.A.M.; Cohen Stuart, M.A.

    2007-01-01

    We present measurements of equilibrium forces resulting from capillary condensation. The results give access to the ultralow interfacial tensions between the capillary bridge and the coexisting bulk phase. We demonstrate this with solutions of associative polymers and an aqueous mixture of gelatin

  16. Molecular dynamics investigation of ferrous-ferric electron transfer in a hydrolyzing aqueous solution: Calculation of the pH dependence of the diabatic transfer barrier and the potential of mean force

    International Nuclear Information System (INIS)

    Rustad, James R.; Rosso, Kevin M.; Felmy, Andrew R.

    2004-01-01

    We present a molecular model for ferrous-ferric electron transfer in an aqueous solution that accounts for electronic polarizability and exhibits spontaneous cation hydrolysis. An extended Lagrangian technique is introduced for carrying out calculations of electron-transfer barriers in polarizable systems. The model predicts that the diabatic barrier to electron transfer increases with increasing pH, due to stabilization of the Fe 3+ by fluctuations in the number of hydroxide ions in its first coordination sphere, in much the same way as the barrier would increase with increasing dielectric constant in the Marcus theory. We have also calculated the effect of pH on the potential of mean force between two hydrolyzing ions in aqueous solution. As expected, increasing pH reduces the potential of mean force between the ferrous and ferric ions in the model system. The magnitudes of the predicted increase in diabatic transfer barrier and the predicted decrease in the potential of mean force nearly cancel each other at the canonical transfer distance of 0.55 nm. Even though hydrolysis is allowed in our calculations, the distribution of reorganization energies has only one maximum and is Gaussian to an excellent approximation, giving a harmonic free energy surface in the reorganization energy F(ΔE) with a single minimum. There is thus a surprising amount of overlap in electron-transfer reorganization energies for Fe 2+ -Fe(H 2 O) 6 3+ , Fe 2+ -Fe(OH)(H 2 O) 5 2+ , and Fe 2+ -Fe(OH) 2 (H 2 O) + couples, indicating that fluctuations in hydrolysis state can be viewed on a continuum with other solvent contributions to the reorganization energy. There appears to be little justification for thinking of the transfer rate as arising from the contributions of different hydrolysis states. Electronic structure calculations indicate that Fe(H 2 O) 6 2+ -Fe(OH) n (H 2 O) 6-n (3-n)+ complexes interacting through H 3 O 2 - bridges do not have large electronic couplings

  17. Finger Forces in Clarinet Playing

    Directory of Open Access Journals (Sweden)

    Alex Hofmann

    2016-08-01

    Full Text Available Clarinettists close and open multiple tone holes to alter the pitch of the tones. Their fingering technique must be fast, precise, and coordinated with the tongue articulation. In this empirical study, finger force profiles and tongue techniques of clarinet students (N = 17 and professional clarinettists (N = 6 were investigated under controlled performance conditions. First, in an expressive-performance task, eight selected excerpts from the first Weber Concerto were performed. These excerpts were chosen to fit in a 2 x 2 x 2 design (register: low--high; tempo: slow--fast, dynamics: soft--loud. There was an additional condition controlled by the experimenter, which determined the expression levels (low--high of the performers. Second, a technical-exercise task, an isochronous 23-tone melody was designed that required different effectors to produce the sequence (finger-only, tongue-only, combined tongue-finger actions. The melody was performed in three tempo conditions (slow, medium, fast in a synchronization-continuation paradigm. Participants played on a sensor-equipped Viennese clarinet, which tracked finger forces and reed oscillations simultaneously. From the data, average finger force (Fmean and peak force (Fmax were calculated. The overall finger forces were low (Fmean = 1.17 N, Fmax = 3.05 N compared to those on other musical instruments (e.g. guitar. Participants applied the largest finger forces during the high expression level performance conditions (Fmean = 1.21 N.For the technical exercise task, timing and articulation information were extracted from the reed signal. Here, the timing precision of the fingers deteriorated the timing precision of the tongue for combined tongue-finger actions, especially for faster tempi. Although individual finger force profiles were overlapping, the group of professional players applied less finger force overall (Fmean = 0.54 N. Such sensor instruments provide useful insights into player

  18. Nanoparticle movement: Plasmonic forces and physical constraints

    International Nuclear Information System (INIS)

    Batson, P.E.; Reyes-Coronado, A.; Barrera, R.G.; Rivacoba, A.; Echenique, P.M.; Aizpurua, J.

    2012-01-01

    Nanoparticle structures observed in aberration-corrected electron microscopes exhibit many types of behavior, some of which are dominated by intrinsic conditions, unrelated to the microscope environment. Some behaviors are clearly driven by the electron beam, however, and the question arises as to whether these are similar to intrinsic mechanisms, useful for understanding nanoscale behavior, or whether they should be regarded as unwanted modification of as-built specimens. We have studied a particular kind of beam–specimen interaction – plasmon dielectric forces caused by the electric fields imposed by a passing swift electron – identifying four types of forced motion, including both attractive and repulsive forces on single nanoparticles, and coalescent and non-coalescent forces in groups of two or more nanoparticles. We suggest that these forces might be useful for deliberate electron beam guided movement of nanoparticles. -- Highlights: ► We investigate the interaction of metal nanoparticles with a high energy electron beam. ► We find forces ranging from 0.1 to 50 pN forces between the metal particles and the beam. ► At moderate distances, dielectric forces are usually small and attractive. ► At sub-Nm distances the forces become repulsive, pushing nanoparticles away from the electron beam. ► While the repulsive behavior is predicted by electromagnetic theory, the detailed origin of the behavior is not yet understood.

  19. Rate of force development

    DEFF Research Database (Denmark)

    Maffiuletti, Nicola A; Aagaard, Per; Blazevich, Anthony J

    2016-01-01

    The evaluation of rate of force development during rapid contractions has recently become quite popular for characterising explosive strength of athletes, elderly individuals and patients. The main aims of this narrative review are to describe the neuromuscular determinants of rate of force devel...

  20. The forces in Nature

    CERN Multimedia

    CERN AC

    1998-01-01

    The different forces, together with a pictorial analogy of how the exchange of particles works. The table lists the relative strength of the couplings, the quanta associated with the force fields and the bodies of phenomena in which they have a dominant role.

  1. New force in nature?

    International Nuclear Information System (INIS)

    Fischbach, E.; Sudarsky, D.; Szafer, A.; Talmadge, C.; Aronson, S.H.

    1986-01-01

    We review recent experimental and theoretical work dealing with the proposed fifth force. Further analysis of the original Eoetvoes experiments has uncovered no challenges to our original assertion that these data evidence a correlation characteristic of the presence of a new coupling to baryon number or hypercharge. Various models suggest that the proposed fifth force could be accomodated naturally into the existing theoretical framework

  2. Ponderomotive Forces in Cosmos

    Science.gov (United States)

    Lundin, R.; Guglielmi, A.

    2006-12-01

    This review is devoted to ponderomotive forces and their importance for the acceleration of charged particles by electromagnetic waves in space plasmas. Ponderomotive forces constitute time-averaged nonlinear forces acting on a media in the presence of oscillating electromagnetic fields. Ponderomotive forces represent a useful analytical tool to describe plasma acceleration. Oscillating electromagnetic fields are also related with dissipative processes, such as heating of particles. Dissipative processes are, however, left outside these discussions. The focus will be entirely on the (conservative) ponderomotive forces acting in space plasmas. The review consists of seven sections. In Section 1, we explain the rational for using the auxiliary ponderomotive forces instead of the fundamental Lorentz force for the study of particle motions in oscillating fields. In Section 2, we present the Abraham, Miller, Lundin-Hultqvist and Barlow ponderomotive forces, and the Bolotovsky-Serov ponderomotive drift. The hydrodynamic, quasi-hydrodynamic, and ‘`test-particle’' approaches are used for the study of ponderomotive wave-particle interaction. The problems of self-consistency and regularization are discussed in Section 3. The model of static balance of forces (Section 4) exemplifies the interplay between thermal, gravitational and ponderomotive forces, but it also introduces a set of useful definitions, dimensionless parameters, etc. We analyze the Alfvén and ion cyclotron waves in static limit with emphasis on the specific distinction between traveling and standing waves. Particular attention has been given to the impact of traveling Alfvén waves on the steady state anabatic wind that blows over the polar regions (Section~5). We demonstrate the existence of a wave-induced cold anabatic wind. We also show that, at a critical point, the ponderomotive acceleration of the wind is a factor of 3 greater than the thermal acceleration. Section 6 demonstrates various

  3. Imaging stability in force-feedback high-speed atomic force microscopy

    International Nuclear Information System (INIS)

    Kim, Byung I.; Boehm, Ryan D.

    2013-01-01

    We studied the stability of force-feedback high-speed atomic force microscopy (HSAFM) by imaging soft, hard, and biological sample surfaces at various applied forces. The HSAFM images showed sudden topographic variations of streaky fringes with a negative applied force when collected on a soft hydrocarbon film grown on a grating sample, whereas they showed stable topographic features with positive applied forces. The instability of HSAFM images with the negative applied force was explained by the transition between contact and noncontact regimes in the force–distance curve. When the grating surface was cleaned, and thus hydrophilic by removing the hydrocarbon film, enhanced imaging stability was observed at both positive and negative applied forces. The higher adhesive interaction between the tip and the surface explains the improved imaging stability. The effects of imaging rate on the imaging stability were tested on an even softer adhesive Escherichia coli biofilm deposited onto the grating structure. The biofilm and planktonic cell structures in HSAFM images were reproducible within the force deviation less than ∼0.5 nN at the imaging rate up to 0.2 s per frame, suggesting that the force-feedback HSAFM was stable for various imaging speeds in imaging softer adhesive biological samples. - Highlights: ► We investigated the imaging stability of force-feedback HSAFM. ► Stable–unstable imaging transitions rely on applied force and sample hydrophilicity. ► The stable–unstable transitions are found to be independent of imaging rate

  4. Manipulating bubbles with secondary Bjerknes forces

    Energy Technology Data Exchange (ETDEWEB)

    Lanoy, Maxime [Institut Langevin, ESPCI ParisTech, CNRS (UMR 7587), PSL Research University, 1 rue Jussieu, 75005 Paris (France); Laboratoire Matière et Systèmes Complexes, Université Paris-Diderot, CNRS (UMR 7057), 10 rue Alice Domon et Léonie Duquet, 75013 Paris (France); Derec, Caroline; Leroy, Valentin [Laboratoire Matière et Systèmes Complexes, Université Paris-Diderot, CNRS (UMR 7057), 10 rue Alice Domon et Léonie Duquet, 75013 Paris (France); Tourin, Arnaud [Institut Langevin, ESPCI ParisTech, CNRS (UMR 7587), PSL Research University, 1 rue Jussieu, 75005 Paris (France)

    2015-11-23

    Gas bubbles in a sound field are submitted to a radiative force, known as the secondary Bjerknes force. We propose an original experimental setup that allows us to investigate in detail this force between two bubbles, as a function of the sonication frequency, as well as the bubbles radii and distance. We report the observation of both attractive and, more interestingly, repulsive Bjerknes force, when the two bubbles are driven in antiphase. Our experiments show the importance of taking multiple scatterings into account, which leads to a strong acoustic coupling of the bubbles when their radii are similar. Our setup demonstrates the accuracy of secondary Bjerknes forces for attracting or repealing a bubble, and could lead to new acoustic tools for noncontact manipulation in microfluidic devices.

  5. Measurement of tool forces in diamond turning

    Energy Technology Data Exchange (ETDEWEB)

    Drescher, J.; Dow, T.A.

    1988-12-01

    A dynamometer has been designed and built to measure forces in diamond turning. The design includes a 3-component, piezoelectric transducer. Initial experiments with this dynamometer system included verification of its predicted dynamic characteristics as well as a detailed study of cutting parameters. Many cutting experiments have been conducted on OFHC Copper and 6061-T6 Aluminum. Tests have involved investigation of velocity effects, and the effects of depth and feedrate on tool forces. Velocity has been determined to have negligible effects between 4 and 21 m/s. Forces generally increase with increasing depth of cut. Increasing feedrate does not necessarily lead to higher forces. Results suggest that a simple model may not be sufficient to describe the forces produced in the diamond turning process.

  6. Tendon Force Transmission at the Nanoscale

    DEFF Research Database (Denmark)

    Svensson, René

    2013-01-01

    of connective tissue function that are poorly understood. One such aspect is the microscopic mechanisms of force transmission through tendons over macroscopic distances. Force transmission is at the heart of tendon function, but the large range of scales in the hierarchical structure of tendons has made...... it difficult to tackle. The tendon hierarchy ranges from molecules (2 nm) over fibrils (200 nm), fibers (2 μm) and fascicles (200 μm) to tendons (10 mm), and to derive the mechanisms of force transmission it is necessary to know the mechanical behavior at each hierarchical level. The aim of the present work...... was to elucidate the mechanisms of force transmission in tendons primarily by investigating the mechanical behavior at the hierarchical level of collagen fibrils. To do so we have developed an atomic force microscopy (AFM) method for tensile testing of native collagen fibrils. The thesis contains five papers...

  7. Manipulating bubbles with secondary Bjerknes forces

    International Nuclear Information System (INIS)

    Lanoy, Maxime; Derec, Caroline; Leroy, Valentin; Tourin, Arnaud

    2015-01-01

    Gas bubbles in a sound field are submitted to a radiative force, known as the secondary Bjerknes force. We propose an original experimental setup that allows us to investigate in detail this force between two bubbles, as a function of the sonication frequency, as well as the bubbles radii and distance. We report the observation of both attractive and, more interestingly, repulsive Bjerknes force, when the two bubbles are driven in antiphase. Our experiments show the importance of taking multiple scatterings into account, which leads to a strong acoustic coupling of the bubbles when their radii are similar. Our setup demonstrates the accuracy of secondary Bjerknes forces for attracting or repealing a bubble, and could lead to new acoustic tools for noncontact manipulation in microfluidic devices

  8. OOTW Force Design Tools

    Energy Technology Data Exchange (ETDEWEB)

    Bell, R.E.; Hartley, D.S.III; Packard, S.L.

    1999-05-01

    This report documents refined requirements for tools to aid the process of force design in Operations Other Than War (OOTWs). It recommends actions for the creation of one tool and work on other tools relating to mission planning. It also identifies the governmental agencies and commands with interests in each tool, from whom should come the user advisory groups overseeing the respective tool development activities. The understanding of OOTWs and their analytical support requirements has matured to the point where action can be taken in three areas: force design, collaborative analysis, and impact analysis. While the nature of the action and the length of time before complete results can be expected depends on the area, in each case the action should begin immediately. Force design for OOTWs is not a technically difficult process. Like force design for combat operations, it is a process of matching the capabilities of forces against the specified and implied tasks of the operation, considering the constraints of logistics, transport and force availabilities. However, there is a critical difference that restricts the usefulness of combat force design tools for OOTWs: the combat tools are built to infer non-combat capability requirements from combat capability requirements and cannot reverse the direction of the inference, as is required for OOTWs. Recently, OOTWs have played a larger role in force assessment, system effectiveness and tradeoff analysis, and concept and doctrine development and analysis. In the first Quadrennial Defense Review (QDR), each of the Services created its own OOTW force design tool. Unfortunately, the tools address different parts of the problem and do not coordinate the use of competing capabilities. These tools satisfied the immediate requirements of the QDR, but do not provide a long-term cost-effective solution.

  9. The Role of the Electrostatic Force in Spore Adhesion

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Eunhyea [Georgia Institute of Technology; Yiacoumi, Sotira [Georgia Institute of Technology; Lee, Ida [University of Tennessee, Knoxville (UTK); Tsouris, Costas [ORNL

    2010-01-01

    Electrostatic force is investigated as one of the components of the adhesion force between Bacillus thuringiensis (Bt) spores and planar surfaces. The surface potentials of a Bt spore and a mica surface are experimentally obtained using a combined atomic force microscopy (AFM)-scanning surface potential microscopy technique. On the basis of experimental information, the surface charge density of the spores is estimated at 0.03 {micro}C/cm{sup 2} at 20% relative humidity and decreases with increasing humidity. The Coulombic force is introduced for the spore-mica system (both charged, nonconductive surfaces), and an electrostatic image force is introduced to the spore-gold system because gold is electrically conductive. The Coulombic force for spore-mica is repulsive because the components are similarly charged, while the image force for the spore-gold system is attractive. The magnitude of both forces decreases with increasing humidity. The electrostatic forces are added to other force components, e.g., van der Waals and capillary forces, to obtain the adhesion force for each system. The adhesion forces measured by AFM are compared to the estimated values. It is shown that the electrostatic (Coulombic and image) forces play a significant role in the adhesion force between spores and planar surfaces.

  10. Forced magnetic reconnection

    Science.gov (United States)

    Vekstein, G.

    2017-10-01

    This is a tutorial-style selective review explaining basic concepts of forced magnetic reconnection. It is based on a celebrated model of forced reconnection suggested by J. B. Taylor. The standard magnetohydrodynamic (MHD) theory of this process has been pioneered by Hahm & Kulsrud (Phys. Fluids, vol. 28, 1985, p. 2412). Here we also discuss several more recent developments related to this problem. These include energetics of forced reconnection, its Hall-mediated regime, and nonlinear effects with the associated onset of the secondary tearing (plasmoid) instability.

  11. Bi-Force

    DEFF Research Database (Denmark)

    Sun, Peng; Speicher, Nora K; Röttger, Richard

    2014-01-01

    of pairwise similarities. We first evaluated the power of Bi-Force to solve dedicated bicluster editing problems by comparing Bi-Force with two existing algorithms in the BiCluE software package. We then followed a biclustering evaluation protocol in a recent review paper from Eren et al. (2013) (A...... comparative analysis of biclustering algorithms for gene expressiondata. Brief. Bioinform., 14:279-292.) and compared Bi-Force against eight existing tools: FABIA, QUBIC, Cheng and Church, Plaid, BiMax, Spectral, xMOTIFs and ISA. To this end, a suite of synthetic datasets as well as nine large gene expression...

  12. Controlling Casimir force via coherent driving field

    Science.gov (United States)

    Ahmad, Rashid; Abbas, Muqaddar; Ahmad, Iftikhar; Qamar, Sajid

    2016-04-01

    A four level atom-field configuration is used to investigate the coherent control of Casimir force between two identical plates made up of chiral atomic media and separated by vacuum of width d. The electromagnetic chirality-induced negative refraction is obtained via atomic coherence. The behavior of Casimir force is investigated using Casimir-Lifshitz formula. It is noticed that Casimir force can be switched from repulsive to attractive and vice versa via coherent control of the driving field. This switching feature provides new possibilities of using the repulsive Casimir force in the development of new emerging technologies, such as, micro-electro-mechanical and nano-electro-mechanical systems, i.e., MEMS and NEMS, respectively.

  13. Cicada (Tibicen linnei steers by force vectoring

    Directory of Open Access Journals (Sweden)

    Samane Zeyghami

    2016-03-01

    Full Text Available To change flight direction, flying animals modulate aerodynamic force either relative to their bodies to generate torque about the center of mass, or relative to the flight path to produce centripetal force that curves the trajectory. In employing the latter, the direction of aerodynamic force remains fixed in the body frame and rotations of the body redirect the force. While both aforementioned techniques are essential for flight, it is critical to investigate how an animal balances the two to achieve aerial locomotion. Here, we measured wing and body kinematics of cicada (Tibicen linnei in free flight, including flight periods of both little and substantial body reorientations. It is found that cicadas employ a common force vectoring technique to execute all these flights. We show that the direction of the half-stroke averaged aerodynamic force relative to the body is independent of the body orientation, varying in a range of merely 20 deg. Despite directional limitation of the aerodynamic force, pitch and roll torque are generated by altering wing angle of attack and its mean position relative to the center of mass. This results in body rotations which redirect the wing force in the global frame and consequently change the flight trajectory.

  14. Production of isometric forces during sustained acceleration.

    Science.gov (United States)

    Sand, D P; Girgenrath, M; Bock, O; Pongratz, H

    2003-06-01

    The operation of high-performance aircraft requires pilots to apply finely graded forces on controls. Since they are often exposed to high levels of acceleration in flight, we investigated to what extent this ability is degraded in such an environment. Twelve healthy non-pilot volunteers were seated in the gondola of a centrifuge and their performance was tested at normal gravity (1 G) and while exposed to sustained forces of 1.5 G and 3 G oriented from head to foot (+Gz). Using an isometric joystick, they attempted to produce force vectors with specific lengths and directions commanded in random order by a visual display. Acceleration had substantial effects on the magnitude of produced force. Compared with 1 G, maximum produced force was about 2 N higher at 1.5 G and about 10 N higher at 3 G. The size of this effect was constant across the different magnitudes, but varied with the direction of the prescribed force. Acceleration degrades control of force production. This finding may indicate that the motor system misinterprets the unusual gravitoinertial environment and/or that proprioceptive feedback is degraded due to increased muscle tone. The production of excessive isometric force could affect the safe operation of high-performance aircraft.

  15. Institutionalizing Security Force Assistance

    National Research Council Canada - National Science Library

    Binetti, Michael R

    2008-01-01

    .... It looks at the manner in which security assistance guidance is developed and executed. An examination of national level policy and the guidance from senior military and civilian leaders highlights the important role of Security Force Assistance...

  16. Hanscom Air Force Base

    Data.gov (United States)

    Federal Laboratory Consortium — MIT Lincoln Laboratory occupies 75 acres (20 acres of which are MIT property) on the eastern perimeter of Hanscom Air Force Base, which is at the nexus of Lexington,...

  17. Packing force data correlations

    International Nuclear Information System (INIS)

    Heiman, S.M.

    1994-01-01

    One of the issues facing valve maintenance personnel today deals with an appropriate methodology for installing and setting valve packing that will minimize leak rates, yet ensure functionality of the the valve under all anticipated operating conditions. Several variables can affect a valve packing's ability to seal, such as packing bolt torque, stem finish, and lubrication. Stem frictional force can be an excellent overall indicator of some of the underlying conditions that affect the sealing characteristics of the packing and the best parameter to use when adjusting the packing. This paper addresses stem friction forces, analytically derives the equations related to these forces, presents a methodology for measuring these forces on valve stems, and attempts to correlate the data directly to the underlying variables

  18. Expeditionary Warfare- Force Protection

    National Research Council Canada - National Science Library

    Higgins, Eric

    2004-01-01

    In 2003, the Systems Engineering and Analysis students were tasked to develop a system of systems conceptual solution to provide force protection for the Sea Base conceptualized in the 2002 Expeditionary Warfare study...

  19. Axial forces in centrifugal compressor couplings

    Science.gov (United States)

    Ivanov, A. N.; Ivanov, N. M.; Yun, V. K.

    2017-08-01

    The article presents the results of the theoretical and experimental investigation of axial forces arising in the toothed and plate couplings of centrifugal compressor shaft lines. Additional loads on the thrust bearing are considered that can develop in the toothed couplings as a result of coupled rotors misalignment. Design relationships to evaluate the level of axial forces and recommendations for their reduction in the operating conditions are given.

  20. No pressure to make forced solutions for refrigerating agents. New investigation on the eco-efficiency of refrigeration plants in supermarkets; Kaeltemittel-Loesungen nicht uebers Knie brechen. Neue Studie zur Oekoeffizienz von Supermarktkaelteanlagen

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2010-12-15

    Since the commitment of the European Union to reduce greenhouse gases by twenty per cent, the food retailing is extremely under pressure to reduce the emissions of carbon dioxide. The refrigeration equipment offers an important approach because generally approximately fifty per cent of the energy consumption in the supermarket is caused by the refrigeration equipment. In a new investigation, the British institute SKM Enviros (London, United Kingdom) analyzed and compared different technologies.

  1. The influence of lower leg configurations on muscle force variability.

    Science.gov (United States)

    Ofori, Edward; Shim, Jaeho; Sosnoff, Jacob J

    2018-04-11

    The maintenance of steady contractions is required in many daily tasks. However, there is little understanding of how various lower limb configurations influence the ability to maintain force. The purpose of the current investigation was to examine the influence of joint angle on various lower-limb constant force contractions. Nineteen adults performed knee extension, knee flexion, and ankle plantarflexion isometric force contractions to 11 target forces, ranging from 2 to 95% maximal voluntary contraction (MVC) at 2 angles. Force variability was quantified with mean force, standard deviation, and the coefficient of variation of force output. Non-linearities in force output were quantified with approximate entropy. Curve fitting analyses were performed on each set of data from each individual across contractions to further examine whether joint angle interacts with global functions of lower-limb force variability. Joint angle had significant effects on the model parameters used to describe the force-variability function for each muscle contraction (p force output were more explained by force level in smaller angle conditions relative to the larger angle conditions (p force production. Biomechanical factors, such as joint angle, along with neurophysiological factors should be considered together in the discussion of the dynamics of constant force production. Copyright © 2018 Elsevier Ltd. All rights reserved.

  2. Forces in strategy formation

    DEFF Research Database (Denmark)

    Steensen, Elmer Fly; Sanchez, Ron

    2008-01-01

    This chapter proposes that organizational strategy formation should be characterized theoretically as a process that is subject to several interacting forces, rather than represented by separate discrete decisionmodels or theoretic perspectives, as is commonly done in the strategic management...... literature. Based on an extensive review of relevant theory and empirical work in strategic decision-making, organizational change theory, cognitive and social psychology, and strategy processes, seven kinds of ''forces'' - rational, imposed, teleological, learning, political, heuristic, and social...... - are identified as interacting in and having significant influence on the strategy formation process. It is further argued that by applying a holistic ''forces-view'' of the significant and interacting influences on strategy formation, we can better understand the dynamics and challenges in managing the process...

  3. Installation and investigation of a cogeneration system in a hospital building at Anieres; Installation et suivi d'un couplage chaleur-force (CCF) sur le site de l'ORT a Anieres

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    A system for combined heat and power generation has been added to the complex energy system of the ORT building of the general hospital at Anieres (canton Geneva, Southwestern Switzerland). Such a system allows both to reduce deficiencies of electric power and to supply the necessary sanitary hot water. The detailed investigation showed that the hydraulic inclusion of the cogeneration unit is of prime importance for obtaining a high number of operating hours, a prerequisite for economic operation. A hydraulic control of the primary loop by a temperature sensor in the return flow has proven to be adequate. Another critical point is the control of the cogeneration unit. The control must be very precisely adjusted if the requirements for electric power and warm water are to be fulfilled without heat dissipation. In this context, the management of the warm water storage tanks plays a decisive role.

  4. Detecting chameleons through Casimir force measurements

    International Nuclear Information System (INIS)

    Brax, Philippe; Bruck, Carsten van de; Davis, Anne-Christine; Shaw, Douglas; Mota, David F.

    2007-01-01

    The best laboratory constraints on strongly coupled chameleon fields come not from tests of gravity per se but from precision measurements of the Casimir force. The chameleonic force between two nearby bodies is more akin to a Casimir-like force than a gravitational one: The chameleon force behaves as an inverse power of the distance of separation between the surfaces of two bodies, just as the Casimir force does. Additionally, experimental tests of gravity often employ a thin metallic sheet to shield electrostatic forces; however, this sheet masks any detectable signal due to the presence of a strongly coupled chameleon field. As a result of this shielding, experiments that are designed to specifically test the behavior of gravity are often unable to place any constraint on chameleon fields with a strong coupling to matter. Casimir force measurements do not employ a physical electrostatic shield and as such are able to put tighter constraints on the properties of chameleons fields with a strong matter coupling than tests of gravity. Motivated by this, we perform a full investigation on the possibility of testing chameleon models with both present and future Casimir experiments. We find that present-day measurements are not able to detect the chameleon. However, future experiments have a strong possibility of detecting or rule out a whole class of chameleon models

  5. Force sharing and other collaborative strategies in a dyadic force perception task.

    Science.gov (United States)

    Tatti, Fabio; Baud-Bovy, Gabriel

    2018-01-01

    When several persons perform a physical task jointly, such as transporting an object together, the interaction force that each person experiences is the sum of the forces applied by all other persons on the same object. Therefore, there is a fundamental ambiguity about the origin of the force that each person experiences. This study investigated the ability of a dyad (two persons) to identify the direction of a small force produced by a haptic device and applied to a jointly held object. In this particular task, the dyad might split the force produced by the haptic device (the external force) in an infinite number of ways, depending on how the two partners interacted physically. A major objective of this study was to understand how the two partners coordinated their action to perceive the direction of the third force that was applied to the jointly held object. This study included a condition where each participant responded independently and another one where the two participants had to agree upon a single negotiated response. The results showed a broad range of behaviors. In general, the external force was not split in a way that would maximize the joint performance. In fact, the external force was often split very unequally, leaving one person without information about the external force. However, the performance was better than expected in this case, which led to the discovery of an unanticipated strategy whereby the person who took all the force transmitted this information to the partner by moving the jointly held object. When the dyad could negotiate the response, we found that the participant with less force information tended to switch his or her response more often.

  6. Force sharing and other collaborative strategies in a dyadic force perception task

    Science.gov (United States)

    Tatti, Fabio

    2018-01-01

    When several persons perform a physical task jointly, such as transporting an object together, the interaction force that each person experiences is the sum of the forces applied by all other persons on the same object. Therefore, there is a fundamental ambiguity about the origin of the force that each person experiences. This study investigated the ability of a dyad (two persons) to identify the direction of a small force produced by a haptic device and applied to a jointly held object. In this particular task, the dyad might split the force produced by the haptic device (the external force) in an infinite number of ways, depending on how the two partners interacted physically. A major objective of this study was to understand how the two partners coordinated their action to perceive the direction of the third force that was applied to the jointly held object. This study included a condition where each participant responded independently and another one where the two participants had to agree upon a single negotiated response. The results showed a broad range of behaviors. In general, the external force was not split in a way that would maximize the joint performance. In fact, the external force was often split very unequally, leaving one person without information about the external force. However, the performance was better than expected in this case, which led to the discovery of an unanticipated strategy whereby the person who took all the force transmitted this information to the partner by moving the jointly held object. When the dyad could negotiate the response, we found that the participant with less force information tended to switch his or her response more often. PMID:29474433

  7. Electrochemical force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Kalinin, Sergei V.; Jesse, Stephen; Collins, Liam F.; Rodriguez, Brian J.

    2017-01-10

    A system and method for electrochemical force microscopy are provided. The system and method are based on a multidimensional detection scheme that is sensitive to forces experienced by a biased electrode in a solution. The multidimensional approach allows separation of fast processes, such as double layer charging, and charge relaxation, and slow processes, such as diffusion and faradaic reactions, as well as capturing the bias dependence of the response. The time-resolved and bias measurements can also allow probing both linear (small bias range) and non-linear (large bias range) electrochemical regimes and potentially the de-convolution of charge dynamics and diffusion processes from steric effects and electrochemical reactivity.

  8. Bolt Shear Force Sensor

    Science.gov (United States)

    2015-03-12

    0030] FIG. 7 is an isometric view of a deformable ring of the bolt shear force sensor of the present invention with an optical Attorney Docket No...102587 9 of 19 fiber having Bragg gratings wound around the ring; [0031] FIG. 8 is an isometric view of the deformable ring with wire strain... strength . [0047] Once the joint is subjected to an external load (see force arrows “F” and “F/2”); any frictional resistance to slip is overcome and

  9. Particles and forces

    International Nuclear Information System (INIS)

    Peierls, R.

    1981-01-01

    The particles and forces of matter, found in the Universe, are discussed with especial reference to some of the laws which govern behaviour in the sub-atomic world and which determine the way forces work to give matter its various characteristics. The recent history of the search for elementary constituents of matter in this century is outlined and the replacement of the simplicity anticipated in the 1930s by the proliferation of particle states uncovered in the 1950s and 1960s which led to the quark model is examined. (U.K.)

  10. Active Magnetic Bearings – Magnetic Forces

    DEFF Research Database (Denmark)

    Kjølhede, Klaus

    2006-01-01

    Parameter identification procedures and model validation are major steps towards intelligent machines supported by active magnetic bearings (AMB). The ability of measuring the electromagnetic bearing forces, or deriving them from measuring the magnetic flux, strongly contributes to the model...... of the work is the characterization of magnetic forces by using two experimental different experimental approaches. Such approaches are investigated and described in details. A special test rig is designed where the 4 poles - AMB is able to generate forces up to 1900 N. The high precision characterization...... of the magnetic forces are led by using different experimental tests: (I) by using hall sensors mounted directly on the poles (precise measurements of the magnetic flux) and by an auxiliary system, composed of strain gages and flexible beams attached to the rotor; (II) by measuring the input current and bearing...

  11. Low force cementation.

    Science.gov (United States)

    Wilson, P R

    1996-07-01

    The marginal adaptation of full coverage restorations is adversely affected by the introduction of luting agents of various minimum film thicknesses during the cementation process. The increase in the marginal opening may have long-term detrimental effects on the health of both pulpal and periodontal tissues. The purpose of this study was to determine the effects of varying seating forces (2.5, 12.5, 25 N), venting, and cement types on post-cementation marginal elevation in cast crowns. A standardized cement space of 40 microns was provided between a machined gold crown and a stainless steel die. An occlusal vent was placed that could be opened or closed. The post-cementation crown elevation was measured, following the use of two commercially available capsulated dental cements (Phosphacap, and Ketac-cem Applicap). The results indicate that only the combination of Ketac-Cem Applicap and crown venting produced post-cementation crown elevation of less than 20 microns when 12.5 N seating force was used. Higher forces (25 N) and venting were required for comparable seating when using Phosphacap (19 microns). The amount of force required to allow maximum seating of cast crowns appears to be cement specific, and is reduced by effective venting procedures.

  12. Separation problems and forcing

    Czech Academy of Sciences Publication Activity Database

    Zapletal, Jindřich

    2013-01-01

    Roč. 13, č. 1 (2013), s. 1350002 ISSN 0219-0613 R&D Projects: GA AV ČR IAA100190902 Institutional research plan: CEZ:AV0Z10190503 Keywords : separation * set of uniqueness * forcing Subject RIV: BA - General Mathematics Impact factor: 0.364, year: 2012 http://www.worldscientific.com/doi/abs/10.1142/S0219061313500025

  13. Activation force splines

    DEFF Research Database (Denmark)

    Engell-Nørregård, Morten Pol; Erleben, Kenny

    We present a method for simulating the active contraction of deformable models, usable for interactive animation of soft deformable objects. We present a novel physical principle as the governing equation for the coupling between the low dimensional 1D activation force model and the higher...

  14. The fifth force

    International Nuclear Information System (INIS)

    Fischbach, E.; Sudarsky, D.; Szafer, A.; Talmadge, C.; Aronson, S.H.

    1986-01-01

    We present a phenomenological description of the ''fifth force'' which focuses on the implications of the existing data from satellite and geophysical measurements of gravity, the Eoetvoes experiment, decays into hyperphotons, and the energy-dependence of the K 0 - anti K 0 parameters

  15. Air Force Leadership Diversity

    Science.gov (United States)

    2017-04-06

    served as a deputy maintenance group commander. Following Air War College he will take command of the 8th Maintenance Group, Kunsan Air Base, Korea ...discrimination in terms of 3 race, religion , sex, etc.: the demographics we have all heard about for years. Air Force Policy Directive (AFPD) 36

  16. Projective absoluteness for Sacks forcing

    NARCIS (Netherlands)

    Ikegami, D.

    2009-01-01

    We show that Sigma(1)(3)-absoluteness for Sacks forcing is equivalent to the nonexistence of a Delta(1)(2) Bernstein set. We also show that Sacks forcing is the weakest forcing notion among all of the preorders that add a new real with respect to Sigma(1)(3) forcing absoluteness.

  17. Biodegradable Piezoelectric Force Sensor.

    Science.gov (United States)

    Curry, Eli J; Ke, Kai; Chorsi, Meysam T; Wrobel, Kinga S; Miller, Albert N; Patel, Avi; Kim, Insoo; Feng, Jianlin; Yue, Lixia; Wu, Qian; Kuo, Chia-Ling; Lo, Kevin W-H; Laurencin, Cato T; Ilies, Horea; Purohit, Prashant K; Nguyen, Thanh D

    2018-01-30

    Measuring vital physiological pressures is important for monitoring health status, preventing the buildup of dangerous internal forces in impaired organs, and enabling novel approaches of using mechanical stimulation for tissue regeneration. Pressure sensors are often required to be implanted and directly integrated with native soft biological systems. Therefore, the devices should be flexible and at the same time biodegradable to avoid invasive removal surgery that can damage directly interfaced tissues. Despite recent achievements in degradable electronic devices, there is still a tremendous need to develop a force sensor which only relies on safe medical materials and requires no complex fabrication process to provide accurate information on important biophysiological forces. Here, we present a strategy for material processing, electromechanical analysis, device fabrication, and assessment of a piezoelectric Poly-l-lactide (PLLA) polymer to create a biodegradable, biocompatible piezoelectric force sensor, which only employs medical materials used commonly in Food and Drug Administration-approved implants, for the monitoring of biological forces. We show the sensor can precisely measure pressures in a wide range of 0-18 kPa and sustain a reliable performance for a period of 4 d in an aqueous environment. We also demonstrate this PLLA piezoelectric sensor can be implanted inside the abdominal cavity of a mouse to monitor the pressure of diaphragmatic contraction. This piezoelectric sensor offers an appealing alternative to present biodegradable electronic devices for the monitoring of intraorgan pressures. The sensor can be integrated with tissues and organs, forming self-sensing bionic systems to enable many exciting applications in regenerative medicine, drug delivery, and medical devices.

  18. Kelvin probe force microscopy in liquid using electrochemical force microscopy

    Directory of Open Access Journals (Sweden)

    Liam Collins

    2015-01-01

    Full Text Available Conventional closed loop-Kelvin probe force microscopy (KPFM has emerged as a powerful technique for probing electric and transport phenomena at the solid–gas interface. The extension of KPFM capabilities to probe electrostatic and electrochemical phenomena at the solid–liquid interface is of interest for a broad range of applications from energy storage to biological systems. However, the operation of KPFM implicitly relies on the presence of a linear lossless dielectric in the probe–sample gap, a condition which is violated for ionically-active liquids (e.g., when diffuse charge dynamics are present. Here, electrostatic and electrochemical measurements are demonstrated in ionically-active (polar isopropanol, milli-Q water and aqueous NaCl and ionically-inactive (non-polar decane liquids by electrochemical force microscopy (EcFM, a multidimensional (i.e., bias- and time-resolved spectroscopy method. In the absence of mobile charges (ambient and non-polar liquids, KPFM and EcFM are both feasible, yielding comparable contact potential difference (CPD values. In ionically-active liquids, KPFM is not possible and EcFM can be used to measure the dynamic CPD and a rich spectrum of information pertaining to charge screening, ion diffusion, and electrochemical processes (e.g., Faradaic reactions. EcFM measurements conducted in isopropanol and milli-Q water over Au and highly ordered pyrolytic graphite electrodes demonstrate both sample- and solvent-dependent features. Finally, the feasibility of using EcFM as a local force-based mapping technique of material-dependent electrostatic and electrochemical response is investigated. The resultant high dimensional dataset is visualized using a purely statistical approach that does not require a priori physical models, allowing for qualitative mapping of electrostatic and electrochemical material properties at the solid–liquid interface.

  19. The influence of residual stresses on small through-clad cracks in pressure vessels

    International Nuclear Information System (INIS)

    deLorenzi, H.G.; Schumacher, B.I.

    1984-01-01

    The influence of cladding residual stresses on the crack driving force for shallow cracks in the wall of a nuclear pressure vessel is investigated. Thermo-elastic-plastic analyses were carried out on long axial through-clad and sub-clad flaws on the inside of the vessel. The depth of the flaws were one and three times the cladding thickness, respectively. An analysis of a semielliptical axial through-clad flaw was also performed. It was assumed that the residual stresses arise due to the difference in the thermal expansion between the cladding and the base material during the cool down from stress relieving temperature to room temperature and due to the subsequent proof test before the vessel is put into service. The variation of the crack tip opening displacement during these loadings and during a subsequent thermal shock on the inside wall is described. The analyses for the long axial flaws suggest that the crack driving force is smaller for this type of flaw if the residual stresses in the cladding are taken into account than if one assumes that the cladding has no residual stresses. However, the analysis of the semielliptical flaw shows significantly different results. Here the crack driving force is higher than when the residual stresses are not taken into account and is maximum in the cladding at or near the clad/base material interface. This suggests that the crack would propagate along the clad/base material interface before it would penetrate deeper into the wall. The elastic-plastic behavior found in the analyses show that the cladding and the residual stresses in the cladding should be taken into acocunt when evaluating the severity of shallow surface cracks on the inside of a nuclear pressure vessel

  20. Casimir forces and geometry

    International Nuclear Information System (INIS)

    Buescher, R.

    2005-01-01

    Casimir interactions are interactions induced by quantum vacuum fluctuations and thermal fluctuations of the electromagnetic field. Using a path integral quantization for the gauge field, an effective Gaussian action will be derived which is the starting point to compute Casimir forces between macroscopic objects analytically and numerically. No assumptions about the independence of the material and shape dependent contributions to the interaction are made. We study the limit of flat surfaces in further detail and obtain a concise derivation of Lifshitz' theory of molecular forces. For the case of ideally conducting boundaries, the Gaussian action will be calculated explicitly. Both limiting cases are also discussed within the framework of a scalar field quantization approach, which is applicable for translationally invariant geometries. We develop a non-perturbative approach to calculate the Casimir interaction from the Gaussian action for periodically deformed and ideally conducting objects numerically. The obtained results reveal two different scaling regimes for the Casimir force as a function of the distance between the objects, their deformation wavelength and -amplitude. The results confirm that the interaction is non-additive, especially in the presence of strong geometric deformations. Furthermore, the numerical approach is extended to calculate lateral Casimir forces. The results are consistent with the results of the proximity-force approximation for large deformation wavelengths. A qualitatively different behaviour between the normal and lateral force is revealed. We also establish a relation between the boundary induced change of the of the density of states for the scalar Helmholtz equation and the Casimir interaction using the path integral method. For statically deformed boundaries, this relation can be expressed as a novel trace formula, which is formally similar to the so-called Krein-Friedel-Lloyd formula. While the latter formula describes the

  1. Single molecule atomic force microscopy and force spectroscopy of chitosan.

    Science.gov (United States)

    Kocun, Marta; Grandbois, Michel; Cuccia, Louis A

    2011-02-01

    Atomic force microscopy (AFM) and AFM-based force spectroscopy was used to study the desorption of individual chitosan polymer chains from substrates with varying chemical composition. AFM images of chitosan adsorbed onto a flat mica substrate show elongated single strands or aggregated bundles. The aggregated state of the polymer is consistent with the high level of flexibility and mobility expected for a highly positively charged polymer strand. Conversely, the visualization of elongated strands indicated the presence of stabilizing interactions with the substrate. Surfaces with varying chemical composition (glass, self-assembled monolayer of mercaptoundecanoic acid/decanethiol and polytetrafluoroethylene (PTFE)) were probed with chitosan modified AFM tips and the corresponding desorption energies, calculated from plateau-like features, were attributed to the desorption of individual polymer strands. Desorption energies of 2.0±0.3×10(-20)J, 1.8±0.3×10(-20)J and 3.5±0.3×10(-20)J were obtained for glass, SAM of mercaptoundecanoic/dodecanethiol and PTFE, respectively. These single molecule level results can be used as a basis for investigating chitosan and chitosan-based materials for biomaterial applications. Copyright © 2010 Elsevier B.V. All rights reserved.

  2. Mechanical design and force calibration of dual-axis micromechanical probe for friction force microscopy

    International Nuclear Information System (INIS)

    Fukuzawa, Kenji; Terada, Satoshi; Shikida, Mitsuhiro; Amakawa, Hiroaki; Zhang, Hedong; Mitsuya, Yasunaga

    2007-01-01

    A dual-axis micromechanical probe that combines a double cantilever and torsion beams is presented. This probe can reduce the mechanical cross-talk between the lateral and vertical force detections. In addition, dual-axis forces can be detected by measuring the dual-axis displacement of the probe end using the optical lever-based method used in conventional friction force microscopes (FFMs). In this paper, the mechanical design of the probe, the details of the fabrication method, FFM performance, and calibration of the friction force are discussed. The mechanical design and the microfabrication method for probes that can provide a force resolution of the order of 1 nN without mechanical cross-talk are presented. Calibration of the lateral force signal is possible by using the relationship between the lateral force and the piezodisplacement at the onset of the probe scanning. The micromechanical probe enables simultaneous and independent detection of atomic and friction forces. This leads to accurate investigation of nanotribological phenomena and visualization of the distribution of the friction properties, which helps the identification of the material properties

  3. Localization and force analysis at the single virus particle level using atomic force microscopy

    International Nuclear Information System (INIS)

    Liu, Chih-Hao; Horng, Jim-Tong; Chang, Jeng-Shian; Hsieh, Chung-Fan; Tseng, You-Chen; Lin, Shiming

    2012-01-01

    Highlights: ► Localization of single virus particle. ► Force measurements. ► Force mapping. -- Abstract: Atomic force microscopy (AFM) is a vital instrument in nanobiotechnology. In this study, we developed a method that enables AFM to simultaneously measure specific unbinding force and map the viral glycoprotein at the single virus particle level. The average diameter of virus particles from AFM images and the specificity between the viral surface antigen and antibody probe were integrated to design a three-stage method that sets the measuring area to a single virus particle before obtaining the force measurements, where the influenza virus was used as the object of measurements. Based on the purposed method and performed analysis, several findings can be derived from the results. The mean unbinding force of a single virus particle can be quantified, and no significant difference exists in this value among virus particles. Furthermore, the repeatability of the proposed method is demonstrated. The force mapping images reveal that the distributions of surface viral antigens recognized by antibody probe were dispersed on the whole surface of individual virus particles under the proposed method and experimental criteria; meanwhile, the binding probabilities are similar among particles. This approach can be easily applied to most AFM systems without specific components or configurations. These results help understand the force-based analysis at the single virus particle level, and therefore, can reinforce the capability of AFM to investigate a specific type of viral surface protein and its distributions.

  4. Principles and applications of force spectroscopy using atomic force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Kyu; Kim, Woong; Park, Joon Won [Dept. of Chemistry, Pohang University of Science and Technology, Pohang (Korea, Republic of)

    2016-12-15

    Single-molecule force spectroscopy is a powerful technique for addressing single molecules. Unseen structures and dynamics of molecules have been elucidated using force spectroscopy. Atomic force microscope (AFM)-based force spectroscopy studies have provided picoNewton force resolution, subnanometer spatial resolution, stiffness of substrates, elasticity of polymers, and thermodynamics and kinetics of single-molecular interactions. In addition, AFM has enabled mapping the distribution of individual molecules in situ, and the quantification of single molecules has been made possible without modification or labeling. In this review, we describe the basic principles, sample preparation, data analysis, and applications of AFM-based force spectroscopy and its future.

  5. Neural control of muscle force: indications from a simulation model

    Science.gov (United States)

    Luca, Carlo J. De

    2013-01-01

    We developed a model to investigate the influence of the muscle force twitch on the simulated firing behavior of motoneurons and muscle force production during voluntary isometric contractions. The input consists of an excitatory signal common to all the motor units in the pool of a muscle, consistent with the “common drive” property. Motor units respond with a hierarchically structured firing behavior wherein at any time and force, firing rates are inversely proportional to recruitment threshold, as described by the “onion skin” property. Time- and force-dependent changes in muscle force production are introduced by varying the motor unit force twitches as a function of time or by varying the number of active motor units. A force feedback adjusts the input excitation, maintaining the simulated force at a target level. The simulations replicate motor unit behavior characteristics similar to those reported in previous empirical studies of sustained contractions: 1) the initial decrease and subsequent increase of firing rates, 2) the derecruitment and recruitment of motor units throughout sustained contractions, and 3) the continual increase in the force fluctuation caused by the progressive recruitment of larger motor units. The model cautions the use of motor unit behavior at recruitment and derecruitment without consideration of changes in the muscle force generation capacity. It describes an alternative mechanism for the reserve capacity of motor units to generate extraordinary force. It supports the hypothesis that the control of motoneurons remains invariant during force-varying and sustained isometric contractions. PMID:23236008

  6. Task Force report

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    The International Task Force on Prevention of Nuclear Terrorism was formed in 1985 under the auspices of the Nuclear Control Institute. This report is a consensus report of the 26 task force members - all members not necessarily agreeing on every point and all wordings, but in each case a substantial majority did agree. First, the report defines the threat, then establishes the priorities. Short-term recommendations are presented on: (1) protecting nuclear weapons; (2) protecting nuclear materials; (3) protecting nuclear facilities; (4) intelligence programs; (5) civil liberties concerns; (6) controlling nuclear transfers; (7) US - Soviet cooperation; (8) arms control initiatives; (9) convention of physical protection of nuclear material; (10) role of emergency management programs; and (11) role of the media. Brief long-term recommendations are included on (1) international measures, and (2) emerging nuclear technologies. An Appendix, Production of Nuclear Materials Usable in Weapons is presented for further consideration (without recommendations)

  7. Force Modulator System

    Energy Technology Data Exchange (ETDEWEB)

    Redmond Clark

    2009-04-30

    Many metal parts manufacturers use large metal presses to shape sheet metal into finished products like car body parts, jet wing and fuselage surfaces, etc. These metal presses take sheet metal and - with enormous force - reshape the metal into a fully formed part in a manner of seconds. Although highly efficient, the forces involved in forming metal parts also damage the press itself, limit the metals used in part production, slow press operations and, when not properly controlled, cause the manufacture of large volumes of defective metal parts. To date, the metal-forming industry has not been able to develop a metal-holding technology that allows full control of press forces during the part forming process. This is of particular importance in the automotive lightweighting efforts under way in the US automotive manufacturing marketplace. Metalforming Controls Technology Inc. (MC2) has developed a patented press control system called the Force Modulator that has the ability to control these press forces, allowing a breakthrough in stamping process control. The technology includes a series of hydraulic cylinders that provide controlled tonnage at all points in the forming process. At the same time, the unique cylinder design allows for the generation of very high levels of clamping forces (very high tonnages) in very small spaces; a requirement for forming medium and large panels out of HSS and AHSS. Successful production application of these systems testing at multiple stamping operations - including Ford and Chrysler - has validated the capabilities and economic benefits of the system. Although this technology has been adopted in a number of stamping operations, one of the primary barriers to faster adoption and application of this technology in HSS projects is system cost. The cost issue has surfaced because the systems currently in use are built for each individual die as a custom application, thus driving higher tooling costs. This project proposed to better

  8. The Ay puzzle and the nuclear force

    International Nuclear Information System (INIS)

    Hueber, D.

    1999-01-01

    The nucleon-deuteron analyzing power A y in elastic nucleon-deuteron scattering poses a longstanding puzzle. At energies E lab below approximately 30 MeV, A y cannot be described by any realistic NN force. The inclusion of existing three-nucleon forces does not improve the situation. Because of recent questions about the 3 P J NN phases, we examine whether reasonable changes in the NN force can resolve the puzzle. In order to do this, we investigate the effect on the 3 P J waves produced by changes in different parts of the potential (viz., the central force, tensor force, etc.), as well as on the 2-body observables and on A y . We find that it is not possible with reasonable changes in the NN potential to increase the 3-body A y , and at the same time to keep the 2-body observables unchanged. We therefore conclude that the A y puzzle is likely to be solved by new three-nucleon forces, such as those of spin-orbit type, which have not yet been taken into account. Refs. 7, tab. 1 (author)

  9. The Ay puzzle and the nuclear force

    International Nuclear Information System (INIS)

    Hueber, D.; Friar, J.L.

    1998-01-01

    The nucleon-deuteron analyzing power A y in elastic nucleon-deuteron scattering poses a longstanding puzzle. At energies E lab below approximately 30 MeV A y cannot be described by any realistic nucleon-nucleon (NN) force. The inclusion of existing three-nucleon forces does not improve the situation. Because of recent questions about the 3 P J NN phases, we examine whether reasonable changes in the NN force can resolve the puzzle. In order to do this we investigate the effect on the 3 P J waves produced by changes in different parts of the potential (viz., the central force, tensor force, etc.), as well as on the two-body observables and on A y . We find that it is not possible with reasonable changes in the NN potential to increase the three-body A y and at the same time to keep the two-body observables unchanged. We therefore conclude that the A y puzzle is likely to be solved by new three-nucleon forces, such as those of the spin-orbit type, which have not yet been taken into account. copyright 1998 The American Physical Society

  10. ``Force,'' ontology, and language

    Science.gov (United States)

    Brookes, David T.; Etkina, Eugenia

    2009-06-01

    We introduce a linguistic framework through which one can interpret systematically students’ understanding of and reasoning about force and motion. Some researchers have suggested that students have robust misconceptions or alternative frameworks grounded in everyday experience. Others have pointed out the inconsistency of students’ responses and presented a phenomenological explanation for what is observed, namely, knowledge in pieces. We wish to present a view that builds on and unifies aspects of this prior research. Our argument is that many students’ difficulties with force and motion are primarily due to a combination of linguistic and ontological difficulties. It is possible that students are primarily engaged in trying to define and categorize the meaning of the term “force” as spoken about by physicists. We found that this process of negotiation of meaning is remarkably similar to that engaged in by physicists in history. In this paper we will describe a study of the historical record that reveals an analogous process of meaning negotiation, spanning multiple centuries. Using methods from cognitive linguistics and systemic functional grammar, we will present an analysis of the force and motion literature, focusing on prior studies with interview data. We will then discuss the implications of our findings for physics instruction.

  11. The task force process

    International Nuclear Information System (INIS)

    Applegate, J.S.

    1995-01-01

    This paper focuses on the unique aspects of the Fernald Citizens Task Force process that have contributed to a largely successful public participation effort at Fernald. The Fernald Citizens Task Force passed quickly by many procedural issues. Instead, the Task Force concentrated on (a) educating itself about the site, its problems, and possible solutions, and (b) choosing a directed way to approach its mandate: To make recommendations on several open-quotes big pictureclose quotes issues, including future use of the site, cleanup levels, waste disposition, and cleanup priorities. This paper presents the approach used at Fernald for establishing and running a focused site-specific advisory board, the key issues that have been faced, and how these issues were resolved. The success of Fernald in establishing a strong and functioning site-specific advisory board serves as a useful model for other DOE facilities, although the Fernald model is just one of many approaches that can be taken. However, the approach presented here has worked extremely well for Fernald

  12. Gap Task Force

    CERN Multimedia

    Lissuaer, D

    One of the more congested areas in the ATLAS detector is the GAP region (the area between the Barrel Calorimeter and the End Cap calorimeter) where Inner Detector services, LAr Services and some Tile services all must co-habitat in a very limited area. It has been clear for some time that the space in the GAP region is not sufficient to accommodate all that is needed. In the last few month additional problems of routing all the services to Z=0 have been encountered due to the very limited space between the Tile Calorimeter and the first layer of Muon chambers. The Technical Management Board (TMB) and the Executive Board (EB) decided in the middle of March to establish a Task Force to look at this problem and come up with a solution within well-specified guidelines. The task force consisted of experts from the ID, Muon, Liquid Argon and Tile systems in addition to experts from the Technical Coordination team and the Physics coordinator. The task force held many meetings and in general there were some very l...

  13. Friction Force: From Mechanics to Thermodynamics

    Science.gov (United States)

    Ferrari, Christian; Gruber, Christian

    2010-01-01

    We study some mechanical problems in which a friction force is acting on a system. Using the fundamental concepts of state, time evolution and energy conservation, we explain how to extend Newtonian mechanics to thermodynamics. We arrive at the two laws of thermodynamics and then apply them to investigate the time evolution and heat transfer of…

  14. Early and Late Rate of Force Development

    DEFF Research Database (Denmark)

    Andersen, Lars L; Andersen, Jesper L; Zebis, Mette K

    2010-01-01

    The objective of this study is to investigate the potentially opposing influence of qualitative and quantitative muscular adaptations in response to high-intensity resistance training on contractile rate of force development (RFD) in the early (<100 ms) and later phases (>200 ms) of rising muscle...

  15. Casimir-lifshitz force out of thermal equilibrium and asymptotic nonadditivity

    NARCIS (Netherlands)

    Antezza, Mauro; Pitaevskii, Lev P.; Stringari, Sandro; Svetovoy, Vitaly

    2006-01-01

    We investigate the force acting between two parallel plates held at different temperatures. The force reproduces, as limiting cases, the well-known Casimir-Lifshitz surface-surface force at thermal equilibrium and the surface-atom force out of thermal equilibrium recently derived by M. Antezza et

  16. Intermuscular interaction via myofascial force transmission: Effects of tibialis anterior and extensor digitorum longus length on force transmission from rat extensor digitorum longus muscle

    NARCIS (Netherlands)

    Maas, Huub; Baan, Guus C.; Huijing, P.A.J.B.M.

    2001-01-01

    Force transmission in rat anterior crural compartment, containing tibialis anterior (TA), extensor hallucis longus (EHL) and extensor digitorum longus (EDL) muscles, was investigated. These muscles together with the muscles of the peroneal compartment were excited maximally. Force was measured at

  17. Force microscopy of layering and friction in an ionic liquid

    International Nuclear Information System (INIS)

    Hoth, Judith; Hausen, Florian; Bennewitz, Roland; Müser, Martin H

    2014-01-01

    The mechanical properties of the ionic liquid 1-butyl-1-methylpyrrolidinium tris(pentafluoroethyl) trifluorophosphate ([Py 1,4 ][FAP]) in confinement between a SiO x and a Au(1 1 1) surface are investigated by means of atomic force microscopy (AFM) under electrochemical control. Up to 12 layers of ion pairs can be detected through force measurements while approaching the tip of the AFM to the surface. The particular shape of the force versus distance curve is explained by a model for the interaction between tip, gold surface and ionic liquid, which assumes an exponentially decaying oscillatory force originating from bulk liquid density correlations. Jumps in the tip–sample distance upon approach correspond to jumps of the compliant force sensor between branches of the oscillatory force curve. Frictional force between the laterally moving tip and the surface is detected only after partial penetration of the last double layer between tip and surface. (paper)

  18. Discrete Lattice effect of various forcing methods of body force on immersed Boundary-Lattice Boltzmann method

    Energy Technology Data Exchange (ETDEWEB)

    Son, Sung Wan; Ha, Man Yeong; Yoon, Hyun Sik [Pusan National University, Busan (Korea, Republic of); Jeong, Hae Kwon [POSCO, Pohang (Korea, Republic of); Balachandar, S. [University of Florida, Florida (United States)

    2013-02-15

    We investigate the discrete lattice effect of various forcing methods in the lattice Boltzmann method (LBM) to include the body force obtained from the immersed boundary method (IBM). In the immersed boundary lattice Boltzmann method (IB-LBM), the LBM needs a forcing method to involve the body force on a forcing point near the immersed boundary that is calculated by IBM. The proper forcing method in LBM is derived to include the body force, which appears to resolve problems such as multiphase flow, non-ideal gas behavior, etc. Many researchers have adopted different forcing methods in LBM to involve the body force from IBM, even when they solved similar problems. However, it is necessary to evaluate the discrete lattice effect, which originates from different forcing methods in LBM, to include the effect of the body force from IBM on the results. Consequently, in this study, a rigorous analysis of the discrete lattice effect for different forcing methods in IB-LBM is performed by solving various problems.

  19. Discrete Lattice effect of various forcing methods of body force on immersed Boundary-Lattice Boltzmann method

    International Nuclear Information System (INIS)

    Son, Sung Wan; Ha, Man Yeong; Yoon, Hyun Sik; Jeong, Hae Kwon; Balachandar, S.

    2013-01-01

    We investigate the discrete lattice effect of various forcing methods in the lattice Boltzmann method (LBM) to include the body force obtained from the immersed boundary method (IBM). In the immersed boundary lattice Boltzmann method (IB-LBM), the LBM needs a forcing method to involve the body force on a forcing point near the immersed boundary that is calculated by IBM. The proper forcing method in LBM is derived to include the body force, which appears to resolve problems such as multiphase flow, non-ideal gas behavior, etc. Many researchers have adopted different forcing methods in LBM to involve the body force from IBM, even when they solved similar problems. However, it is necessary to evaluate the discrete lattice effect, which originates from different forcing methods in LBM, to include the effect of the body force from IBM on the results. Consequently, in this study, a rigorous analysis of the discrete lattice effect for different forcing methods in IB-LBM is performed by solving various problems.

  20. Adding Value to Force Diagrams: Representing Relative Force Magnitudes

    Science.gov (United States)

    Wendel, Paul

    2011-05-01

    Nearly all physics instructors recognize the instructional value of force diagrams, and this journal has published several collections of exercises to improve student skill in this area.1-4 Yet some instructors worry that too few students perceive the conceptual and problem-solving utility of force diagrams,4-6 and over recent years a rich variety of approaches has been proposed to add value to force diagrams. Suggestions include strategies for identifying candidate forces,6,7 emphasizing the distinction between "contact" and "noncontact" forces,5,8 and the use of computer-based tutorials.9,10 Instructors have suggested a variety of conventions for constructing force diagrams, including approaches to arrow placement and orientation2,11-13 and proposed notations for locating forces or marking action-reaction force pairs.8,11,14,15

  1. Force transmission in epithelial tissues.

    Science.gov (United States)

    Vasquez, Claudia G; Martin, Adam C

    2016-03-01

    In epithelial tissues, cells constantly generate and transmit forces between each other. Forces generated by the actomyosin cytoskeleton regulate tissue shape and structure and also provide signals that influence cells' decisions to divide, die, or differentiate. Forces are transmitted across epithelia because cells are mechanically linked through junctional complexes, and forces can propagate through the cell cytoplasm. Here, we review some of the molecular mechanisms responsible for force generation, with a specific focus on the actomyosin cortex and adherens junctions. We then discuss evidence for how these mechanisms promote cell shape changes and force transmission in tissues. © 2016 Wiley Periodicals, Inc.

  2. Bacterial biofilms investigated by atomic force microscopy and electrochemistry

    DEFF Research Database (Denmark)

    Hu, Yifan

    Bacterial biofilms are aggregates of microorganisms in which cells adhere to each other and adhere to a solid surface or an animal host cavity. Bacterial biofilms play important roles in human life, and cause serious harm for human society and huge economic losses. The complex composition of bact...

  3. High Reynolds Number Wave Force Investigation in a Wave Flume.

    Science.gov (United States)

    1985-03-01

    RESULTS 43 6.0 CONCLUSIONS 45 7.0 REFERENCES 49 8.0 ACKNOWLEDGEMENTS 51 9.0 TABLES 53 10.0 FIGURES 93 11.0 APPENDIX A" 11.1 Druck Pressure Transducer...adjoining test cylinder by 0.7 mm, which had a negligible influence on the resulting measurements. After the Druck pressure transducers were installed and...dC C 3d 4 ;88dC 38dC CI8 cninfl"nV0to .t" o ,t in cv d-. ,0 en w . nC M..r nin - -0 - I!- I!- V! - -i !V L4JN C; .0 d C0000000 40000008 o .6 C

  4. Plasma particle lofting : experimental investigation of dust removal force

    NARCIS (Netherlands)

    Heijmans, L.C.J.; Nijdam, S.

    2015-01-01

    Dust is everywhere. Sometimes it's harmless, but sometimes it needs to be removed. Especially in modern optical machinery, dust control can be of vital importance. In this research we look at dust on a surface. We focus on the behaviour under influence of a plasma. The dust particles will stick to a

  5. Force modulation for improved conductive-mode atomic force microscopy

    NARCIS (Netherlands)

    Koelmans, W.W.; Sebastian, Abu; Despont, Michel; Pozidis, Haris

    We present an improved conductive-mode atomic force microscopy (C-AFM) method by modulating the applied loading force on the tip. Unreliable electrical contact and tip wear are the primary challenges for electrical characterization at the nanometer scale. The experiments show that force modulation

  6. The effect of magnet size on the levitation force and attractive force of single-domain YBCO bulk superconductors

    International Nuclear Information System (INIS)

    Yang, W M; Chao, X X; Bian, X B; Liu, P; Feng, Y; Zhang, P X; Zhou, L

    2003-01-01

    The levitation forces between a single-domain YBCO bulk and several magnets of different sizes have been measured at 77 K to investigate the effect of the magnet size on the levitation force. It is found that the levitation force reaches a largest (peak) value when the size of the magnet approaches that of the superconductor when the other conditions are fixed. The absolute maximum attractive force (in the field-cooled state) increases with the increasing of the magnet size, and is saturated when the magnet size approaches that of the superconductor. The maximum attractive force in the field-cooled (FC) state is much higher than that of the maximum attractive force in the zero field-cooled (ZFC) state. The results indicate that the effects of magnetic field distribution on the levitation force have to be considered during the designing and manufacturing of superconducting devices

  7. Forced vibrations of rotating circular cylindrical shells

    International Nuclear Information System (INIS)

    Igawa, Hirotaka; Maruyama, Yoshiyuki; Endo, Mitsuru

    1995-01-01

    Forced vibrations of rotating circular cylindrical shells are investigated. Basic equations, including the effect of initial stress due to rotation, are formulated by the finite-element method. The characteristic relations for finite elements are derived from the energy principle by considering the finite strain. The equations of motion can be separated into quasi-static and dynamic ones, i.e., the equations in the steady rotating state and those in the vibration state. Radial concentrated impulses are considered as the external dynamic force. The transient responses of circular cylindrical shells are numerically calculated under various boundary conditions and rotating speeds. (author)

  8. Demoulding force in micro-injection moulding

    DEFF Research Database (Denmark)

    Griffiths, C.A.; Dimov, S.S.; Scholz, S.

    2012-01-01

    The paper reports an experimental study that investigates part demoulding behavior in micro injection moulding (MIM) with a focus on the effects of pressure (P) and temperature (T) on the demoulding forces. Demoulding of a microfluidics part is conducted and the four processing parameters of melt...... temperature (Tb), mould temperature (Tm), holding pressure (Ph) and injection speed (Vi) are analysed. The result using different combinations of process parameters were used to identify the best processing conditions in regards to demoulding forces when moulding micro parts....

  9. Pedestrian-induced lateral forces on footbridges

    DEFF Research Database (Denmark)

    Ingolfsson, Einar Thor; Georgakis, Christos T.; Jönsson, Jeppe

    2012-01-01

    of the underlying pavement. An extensive experimental analysis has been carried out to determine the lateral forces generated by pedestrians when walking on a laterally moving treadmill. Two different conditions are investigated; initially the treadmill is fixed and then it is laterally driven in a sinusoidal...... motion at varying combinations of frequencies (0.33-1.07 Hz) and amplitudes (4.5-48 mm). The component of the pedestrian-induced force which is caused by the laterally moving surface is herewith quantified through equivalent velocity and acceleration proportional coefficients. It is shown that large...

  10. Pedestrian-induced lateral forces on footbridges

    DEFF Research Database (Denmark)

    Ingólfsson, Einar Thór; Georgakis, Christos T.; Jönsson, Jeppe

    2011-01-01

    of the underlying pavement. An extensive experimental analysis has been carried out to determine the lateral forces generated by pedestrians when walking on a laterally moving treadmill. Two different conditions are investigated; initially the treadmill is fixed and then it is laterally driven in a sinusoidal...... motion at varying combinations of frequencies (0.33-1.07 Hz) and amplitudes (4.5-48 mm). The component of the pedestrian-induced force which is caused by the laterally moving surface is herewith quantified through equivalent velocity and acceleration proportional coefficients. It is shown that large...

  11. Modernization of African Armed Forces

    DEFF Research Database (Denmark)

    Mandrup, Thomas

    2015-01-01

    Concept paper framing the debate at the Dakar Forum Workshop on Modernization of Armed forces in Africa.......Concept paper framing the debate at the Dakar Forum Workshop on Modernization of Armed forces in Africa....

  12. Force Dynamics of Verb Complementation

    Directory of Open Access Journals (Sweden)

    Jacek Woźny

    2015-12-01

    Full Text Available Force Dynamics of Verb Complementation The concepts of motion and force are both extensively discussed in cognitive linguistics literature. But they are discussed separately. The first usually in the context of ‘motion situations’ (Talmy, Slobin, Zlatev, the other as part of the Force Dynamics framework, which was developed by Talmy. The aim of this paper is twofold: first, to argue that the concepts of force and motion should not be isolated but considered as two inseparable parts of force-motion events. The second goal is to prove that the modified Force Dynamics (force-motion framework can be used for precise characterization of the verb complementation patterns. To this end, a random sample of 50 sentences containing the verb ‘went’ is analyzed, demonstrating the differences between the categories of intensive and intransitive complementation with respect to the linguistically coded parameters of force and motion.

  13. Atomic Force Microscope

    Energy Technology Data Exchange (ETDEWEB)

    Day, R.D.; Russell, P.E.

    1988-12-01

    The Atomic Force Microscope (AFM) is a recently developed instrument that has achieved atomic resolution imaging of both conducting and non- conducting surfaces. Because the AFM is in the early stages of development, and because of the difficulty of building the instrument, it is currently in use in fewer than ten laboratories worldwide. It promises to be a valuable tool for obtaining information about engineering surfaces and aiding the .study of precision fabrication processes. This paper gives an overview of AFM technology and presents plans to build an instrument designed to look at engineering surfaces.

  14. The law of electromagnetic force

    Directory of Open Access Journals (Sweden)

    V.J. Kutkovetskyy

    2014-06-01

    Full Text Available Calculation peculiarities for Lorentz force, Ampere force, interaction of parallel electric currents, and the moment of electrical machines are analyzed. They have exceptions on application, and they are the rules which result from the law of electromagnetic force as coordinate derivative of the operating magnetic flow. An addition to the direction of electromagnetic force action is proposed. Standards of salient-pole electrical machine designing are considered.

  15. Effect of fatigue on force production and force application technique during repeated sprints.

    Science.gov (United States)

    Morin, Jean-Benoit; Samozino, Pierre; Edouard, Pascal; Tomazin, Katja

    2011-10-13

    We investigated the changes in the technical ability of force application/orientation against the ground vs. the physical capability of total force production after a multiple-set repeated sprints series. Twelve male physical education students familiar with sprint running performed four sets of five 6-s sprints (24s of passive rest between sprints, 3min between sets). Sprints were performed from a standing start on an instrumented treadmill, allowing the computation of vertical (F(V)), net horizontal (F(H)) and total (F(Tot)) ground reaction forces for each step. Furthermore, the ratio of forces was calculated as RF=F(H)F(Tot)(-1), and the index of force application technique (D(RF)) representing the decrement in RF with increase in speed was computed as the slope of the linear RF-speed relationship. Changes between pre- (first two sprints) and post-fatigue (last two sprints) were tested using paired t-tests. Performance decreased significantly (e.g. top speed decreased by 15.7±5.4%; Pmultiple-set repeated sprint series, both the total force production capability and the technical ability to apply force effectively against the ground are altered, the latter to a larger extent than the former. Copyright © 2011 Elsevier Ltd. All rights reserved.

  16. Quantification of Staphylococcus aureus adhesion forces on various dental restorative materials using atomic force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Merghni, Abderrahmen, E-mail: abderrahmen_merghni@yahoo.fr [Laboratoire des Maladies Transmissibles et Substances biologiquement actives (LR99ES27) Faculté de Pharmacie de Monastir, Université de Monastir (Tunisia); Kammoun, Dorra [Laboratoire de Biomatériaux et Biotechnologie, Faculté de Médecine Dentaire, Monastir (Tunisia); Hentati, Hajer [Laboratoire de Recherche en Santé Orale et Réhabilitation Bucco-Faciale (LR12ES11), Faculté de Médecine Dentaire de Monastir, Université de Monastir (Tunisia); Janel, Sébastien [BioImaging Center Lille-FR3642, Lille (France); Popoff, Michka [Cellular Microbiology and Physics of Infection-CNRS UMR8204, INSERM U1019, Institut Pasteur de Lille, Lille University (France); Lafont, Frank [BioImaging Center Lille-FR3642, Lille (France); Cellular Microbiology and Physics of Infection-CNRS UMR8204, INSERM U1019, Institut Pasteur de Lille, Lille University (France); Aouni, Mahjoub [Laboratoire des Maladies Transmissibles et Substances biologiquement actives (LR99ES27) Faculté de Pharmacie de Monastir, Université de Monastir (Tunisia); Mastouri, Maha [Laboratoire des Maladies Transmissibles et Substances biologiquement actives (LR99ES27) Faculté de Pharmacie de Monastir, Université de Monastir (Tunisia); Laboratoire de Microbiologie, CHU Fattouma Bourguiba de Monastir (Tunisia)

    2016-08-30

    Highlights: • 4 dental restorative materials were characterized for roughness, angle contact water and surface free energy. • AFM adhesion forces of S. aureus to tested materials were achieved in presence and absence of salivary conditioning film. • S. aureus initial adhesion is dependent on the surface free energy and roughness. - Abstract: In the oral cavity dental restorative biomaterials can act as a reservoir for infection with opportunistic Staphylococcus aureus pathogen, which can lead to the occurrence of secondary caries and treatment failures. Our aim was to evaluate the adhesion forces by S. aureus on four dental restorative biomaterials and to correlate this finding to differences in specific surface characteristics. Additionally, the influence of salivary conditioning films in exerted adhesion forces was investigated. The substrate hydrophobicity was measured by goniometer and the surface free energy was calculated using the equilibrium advancing contact angle values of water, formamide, and diiodomethane on the tested surfaces. The surface roughness was determined using atomic force microscope (AFM). Additionally, cell force spectroscopy was achieved to quantify the forces that drive cell-substrate interactions. S. aureus bacterium exerted a considerable adhesion forces on various dental restorative materials, which decreased in the presence of saliva conditioning film. The influence of the surface roughness and free energy in initial adhesion appears to be more important than the effect of hydrophobicity, either in presence or absence of saliva coating. Hence, control of surface properties of dental restorative biomaterials is of crucial importance in preventing the attachment and subsequent the biofilm formation.

  17. Quantification of Staphylococcus aureus adhesion forces on various dental restorative materials using atomic force microscopy

    International Nuclear Information System (INIS)

    Merghni, Abderrahmen; Kammoun, Dorra; Hentati, Hajer; Janel, Sébastien; Popoff, Michka; Lafont, Frank; Aouni, Mahjoub; Mastouri, Maha

    2016-01-01

    Highlights: • 4 dental restorative materials were characterized for roughness, angle contact water and surface free energy. • AFM adhesion forces of S. aureus to tested materials were achieved in presence and absence of salivary conditioning film. • S. aureus initial adhesion is dependent on the surface free energy and roughness. - Abstract: In the oral cavity dental restorative biomaterials can act as a reservoir for infection with opportunistic Staphylococcus aureus pathogen, which can lead to the occurrence of secondary caries and treatment failures. Our aim was to evaluate the adhesion forces by S. aureus on four dental restorative biomaterials and to correlate this finding to differences in specific surface characteristics. Additionally, the influence of salivary conditioning films in exerted adhesion forces was investigated. The substrate hydrophobicity was measured by goniometer and the surface free energy was calculated using the equilibrium advancing contact angle values of water, formamide, and diiodomethane on the tested surfaces. The surface roughness was determined using atomic force microscope (AFM). Additionally, cell force spectroscopy was achieved to quantify the forces that drive cell-substrate interactions. S. aureus bacterium exerted a considerable adhesion forces on various dental restorative materials, which decreased in the presence of saliva conditioning film. The influence of the surface roughness and free energy in initial adhesion appears to be more important than the effect of hydrophobicity, either in presence or absence of saliva coating. Hence, control of surface properties of dental restorative biomaterials is of crucial importance in preventing the attachment and subsequent the biofilm formation.

  18. The modal logic of forcing

    NARCIS (Netherlands)

    Hamkins, J.D.; Löwe, B.

    2008-01-01

    A set theoretical assertion psi is forceable or possible, written lozenge psi, if psi holds in some forcing extension, and necessary, written square psi, if psi holds in all forcing extensions. In this forcing interpretation of modal logic, we establish that if ZFC is consistent, then the

  19. Small amplitude atomic force spectroscopy

    NARCIS (Netherlands)

    de Beer, Sissi; van den Ende, Henricus T.M.; Ebeling, Daniel; Mugele, Friedrich Gunther; Bhushan, Bharat

    2011-01-01

    Over the years atomic force microscopy has developed from a pure imaging technique to a tool that can be employed for measuring quantitative tip–sample interaction forces. In this chapter we provide an overview of various techniques to extract quantitative tip–sample forces focusing on both

  20. Force and motion

    CERN Document Server

    Robertson, William C

    2002-01-01

    Intimidated by inertia? Frightened by forces? Mystified by Newton s law of motion? You re not alone and help is at hand. The stop Faking It! Series is perfect for science teachers, home-schoolers, parents wanting to help with homework all of you who need a jargon-free way to learn the background for teaching middle school physical science with confidence. With Bill Roberton as your friendly, able but somewhat irreverent guide, you will discover you CAN come to grips with the basics of force and motion. Combining easy-to-understand explanations with activities using commonly found equipment, this book will lead you through Newton s laws to the physics of space travel. The book is as entertaining as it is informative. Best of all, the author understands the needs of adults who want concrete examples, hands-on activities, clear language, diagrams and yes, a certain amount of empathy. Ideas For Use Newton's laws, and all of the other motion principles presented in this book, do a good job of helping us to underst...

  1. Forces between permanent magnets: experiments and model

    International Nuclear Information System (INIS)

    González, Manuel I

    2017-01-01

    This work describes a very simple, low-cost experimental setup designed for measuring the force between permanent magnets. The experiment consists of placing one of the magnets on a balance, attaching the other magnet to a vertical height gauge, aligning carefully both magnets and measuring the load on the balance as a function of the gauge reading. A theoretical model is proposed to compute the force, assuming uniform magnetisation and based on laws and techniques accessible to undergraduate students. A comparison between the model and the experimental results is made, and good agreement is found at all distances investigated. In particular, it is also found that the force behaves as r −4 at large distances, as expected. (paper)

  2. Forced migration, adolescence, and identity formation.

    Science.gov (United States)

    Anagnostopoulos, Dimitris C; Vlassopoulos, Maria; Lazaratou, Helen

    2006-09-01

    Adolescence is a complex biopsychosocial phenomenon. All the inner-subjective changes in adolescents take place within the context of a specific social environment, which offers the necessary ideological setting that adolescents must confront in the course of their identity formation. Forced migration creates conditions under which the adolescent Ego may be traumatized more easily, resulting in the development of defensive mechanisms, which may interfere with the natural process of identity formation. The aim of this paper is to investigate how a traumatic situation such as forced migration may affect the mechanisms of identity formation in adolescence. For this purpose, clinical material, consisting of two cases of psychoanalytical psychotherapy of adolescents who were forced to immigrate to Greece, is presented and discussed in a psychoanalytical theoretical framework, along with the historical-sociological background.

  3. TRIGA forced shutdowns analysis

    International Nuclear Information System (INIS)

    Negut, Gheorghe; Laslau, Florica

    2008-01-01

    The need for improving the operation leads us to use new methods and strategies. Probabilistic safety assessments and statistical analysis provide insights useful for our reactor operation. This paper is dedicated to analysis of the forced shutdowns during the first reactor operation period, between 1980 to 1989. A forced shutdown data base was designed using data on forced shutdowns collected from the reactor operation logbooks. In order to sort out the forced shutdowns the records have the following fields: - current number, date, equipment failed, failure type (M for mechanical, E for electrical, D for irradiation device, U for human factor failure; - scram mode, SE for external scram, failure of reactor cooling circuits and/or irradiation devices, SR for reactor scram, exceeding of reactor nuclear parameters, SB for reactor scram by control rod drop, SM for manual scram required by the abnormal reactor status; - scram cause, giving more information on the forced shutdown. This data base was processed using DBase III. The data processing techniques are presented. To sort out the data, one of the criteria was the number of scrams per year, failure type, scram mode, etc. There are presented yearly scrams, total operation time in hours, total unavailable time, median unavailable time period, reactor availability A. There are given the formulae used to calculate the reactor operational parameters. There are shown the scrams per year in the 1980 to 1989 period, the reactor operation time per year, the reactor shutdown time per year and the operating time versus down time per year. Total number of scrams in the covered period was 643 which caused a reactor down time of 4282.25 hours. In a table the scrams as sorted on the failure type is shown. Summarising, this study emphasized some problems and difficulties which occurred during the TRIGA reactor operation at Pitesti. One main difficulty in creating this data base was the unstandardized scram record mode. Some times

  4. Choosing in Freedom or Forced to Choose? Introspective Blindness to Psychological Forcing in Stage-Magic

    Science.gov (United States)

    Shalom, Diego E.; de Sousa Serro, Maximiliano G.; Giaconia, Maximiliano; Martinez, Luis M.; Rieznik, Andres; Sigman, Mariano

    2013-01-01

    We investigated an individual ability to identify whether choices were made freely or forced by external parameters. We capitalized on magical setups where the notion of psychological forcing constitutes a well trodden path. In live stage magic, a magician guessed cards from spectators while inquiring how freely they thought they had made the choice. Our data showed a marked blindness in the introspection of free choice. Spectators assigned comparable ratings when choosing the card that the magician deliberately forced them compared to any other card, even in classical forcing, where the magician literally handles a card to the participant This observation was paralleled by a laboratory experiment where we observed modest changes in subjective reports by factors with drastic effect in choice. Pupil dilatation, which is known to tag slow cognitive events related to memory and attention, constitutes an efficient fingerprint to index subjective and objective aspects of choice. PMID:23516455

  5. Choosing in freedom or forced to choose? Introspective blindness to psychological forcing in stage-magic.

    Directory of Open Access Journals (Sweden)

    Diego E Shalom

    Full Text Available We investigated an individual ability to identify whether choices were made freely or forced by external parameters. We capitalized on magical setups where the notion of psychological forcing constitutes a well trodden path. In live stage magic, a magician guessed cards from spectators while inquiring how freely they thought they had made the choice. Our data showed a marked blindness in the introspection of free choice. Spectators assigned comparable ratings when choosing the card that the magician deliberately forced them compared to any other card, even in classical forcing, where the magician literally handles a card to the participant This observation was paralleled by a laboratory experiment where we observed modest changes in subjective reports by factors with drastic effect in choice. Pupil dilatation, which is known to tag slow cognitive events related to memory and attention, constitutes an efficient fingerprint to index subjective and objective aspects of choice.

  6. 32 CFR 631.15 - Air Force policy.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Air Force policy. 631.15 Section 631.15 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL...-Installation Operations (Military Patrols and Investigative Activities) and Policy § 631.15 Air Force policy...

  7. Forced Migration of Colombians : Fear, Historical Memory and ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This project follows two years of successful research under project 102661 on forced migration of Colombians within Colombia and to Ecuador and Canada. Researchers in Colombia and Canada investigated the ways in which fear, historical memory and social representation by and about forced migrants influence their ...

  8. The Origins of Force--Misconceptions and Classroom Controversy.

    Science.gov (United States)

    Steinberg, Melvin S.

    Misconceptions associated with the origins of force and the effectiveness of a bridging strategy for developing correct conceptual models in mechanics are identified for high school physics teachers in this paper. The situation investigated was whether a table exerts an upward force on a book. Student misconceptions related to this phenomenon as…

  9. Use of Force Platforms in Physics and Sport.

    Science.gov (United States)

    Parker, Kerry

    2001-01-01

    The subject of biomechanics is growing as athletes turn to science to improve their performance, and biomechanics interests many students and is a good area in which to investigate forces and Newton's laws. Uses force platforms to quantify such studies. (Author/ASK)

  10. Containment structure tendon investigation

    International Nuclear Information System (INIS)

    Fulton, J.F.; Murray, K.H.

    1983-01-01

    The paper describes an investigation into the possible causes of lower-than-predicted tendon forces which were measured during past tendon surveillances for a concrete containment. The containment is post tensioned by vertical tendons which are anchored into a rock foundation. The tendons were originally stressed in 1969, and lift-off tests were performed on six occasions subsequent to this date over a period of 11 years. The tendon forces measured in these tests were generally lower than predicted, and by 1979 the prestress level in the containment was only marginally above the design requirement. The tendons were retensioned in 1980, and by this time an investigation into the possible causes was underway. Potential causes investigated include the rock anchors and surrounding rock, elastomeric pad creep, wire stresses, thermal effects, stressing equipment and lift-off procedures, and wire stress relaxation. The investigation activities included stress relaxation testing of wires pulled from actual tendons. The stress relaxation test program included wire specimens at several different temperature and initial stress levels and the effect of a varying temperature history on the stress relaxation property of the wires. For purpose of future force predictions of the retensioned tendons, the test program included tests to determine the effect on stress relaxation due to restressing the wires after they had relaxed for 1000 hours and 10,000 hours. (orig./GL)

  11. Short-range fundamental forces

    International Nuclear Information System (INIS)

    Antoniadis, I.; Baessler, S.; Buchner, M.; Fedorov, V.V.; Hoedl, S.; Nesvizhevsky, V.V.; Pignol, G.; Protasov, K.V.; Lambrecht, A.; Reynaud, S.; Sobolev, Y.

    2010-01-01

    We consider theoretical motivations to search for extra short-range fundamental forces as well as experiments constraining their parameters. The forces could be of two types: 1) spin-independent forces; 2) spin-dependent axion-like forces. Different experimental techniques are sensitive in respective ranges of characteristic distances. The techniques include measurements of gravity at short distances, searches for extra interactions on top of the Casimir force, precision atomic and neutron experiments. We focus on neutron constraints, thus the range of characteristic distances considered here corresponds to the range accessible for neutron experiments

  12. Solar and atmospheric forcing on mountain lakes.

    Science.gov (United States)

    Luoto, Tomi P; Nevalainen, Liisa

    2016-10-01

    We investigated the influence of long-term external forcing on aquatic communities in Alpine lakes. Fossil microcrustacean (Cladocera) and macrobenthos (Chironomidae) community variability in four Austrian high-altitude lakes, determined as ultra-sensitive to climate change, were compared against records of air temperature, North Atlantic Oscillation (NAO) and solar forcing over the past ~400years. Summer temperature variability affected both aquatic invertebrate groups in all study sites. The influence of NAO and solar forcing on aquatic invertebrates was also significant in the lakes except in the less transparent lake known to have remained uniformly cold during the past centuries due to summertime snowmelt input. The results suggest that external forcing plays an important role in these pristine ecosystems through their impacts on limnology of the lakes. Not only does the air temperature variability influence the communities but also larger-scale external factors related to atmospheric circulation patterns and solar activity cause long-term changes in high-altitude aquatic ecosystems, through their connections to hydroclimatic conditions and light environment. These findings are important in the assessment of climate change impacts on aquatic ecosystems and in greater understanding of the consequences of external forcing on lake ontogeny. Copyright © 2016 Elsevier B.V. All rights reserved.

  13. Inverse Magnus force in free molecular flow

    Science.gov (United States)

    Herczynski, A.; Weidman, P.

    2003-11-01

    The sidewise force on a spinning sphere translating in a rarified gas is calculated assuming that the flow can be treated as a stream of free molecules. This approach was first introduced by Newton in his investigation of the drag force. While it is not fruitful at subsonic flows in normal conditions, it gives remarkably accurate results at hypersonic speeds. Here it is applied to the high Knudsen number flow over spinning spheres, cylinders, cubes and more generally any spinning parallelepiped. In all cases, the force is in the opposite direction to that of the classical Magnus effect in continuum flow. The simple calculation for a sphere reproduces the isothermal result obtained recently by Borg, et al. (Phys. Fluids, 15, 2003) using Maxwellian distribution functions. For any parallelepiped, including the cube, just like for the sphere and the cylinder, the force is shown to be steady. In each of these, the magnitude of the inverse Magnus force is proprtional to the product of the angular speed, translational speed, and the mas of the gas displaced by the object.

  14. Hydrodynamic Forces from Steep Waves in Rivers

    Energy Technology Data Exchange (ETDEWEB)

    Loevoll, A.

    1996-12-31

    The reservoir behind a hydroelectric power production dam has an enormous potential for destruction in case of a dam break. The present doctoral thesis evaluates the hydrodynamic forces from steep waves in rivers. In the laboratory, forces on a structure shaped as a vertical cylinder of rectangular cross section were measured, and the threshold condition for the bed sediment was investigated. A wave parameter {alpha} is introduced to describe the gradient of a wave front. The flow condition in the flume was reproduced by a 3-D numerical model. For various values of the wave parameter the forces were measured and compared to the drag force calculated from measured depth and velocity. From these comparisons the hydrodynamic force can be calculated as drag only, even in the case of a breaking wave front. The contribution from inertia relative to drag depends on the size of the structure. For larger structures the contributions may be important in steep waves. To study the initiation of motion (of sediments) under unsteady flow, waves of various parameter values were passed over a gravel covered bed. The initiation of motion starts before the peak of the wave, and is given by Shield`s relation if the friction slope is applied. No dependence upon the wave gradient was found. A relation was established which gives the critical shear stress if the friction slope is estimated by the bottom slope. 65 refs., 41 figs., 10 tabs.

  15. Hydrodynamic Forces from Steep Waves in Rivers

    International Nuclear Information System (INIS)

    Loevoll, A.

    1996-01-01

    The reservoir behind a hydroelectric power production dam has an enormous potential for destruction in case of a dam break. The present doctoral thesis evaluates the hydrodynamic forces from steep waves in rivers. In the laboratory, forces on a structure shaped as a vertical cylinder of rectangular cross section were measured, and the threshold condition for the bed sediment was investigated. A wave parameter α is introduced to describe the gradient of a wave front. The flow condition in the flume was reproduced by a 3-D numerical model. For various values of the wave parameter the forces were measured and compared to the drag force calculated from measured depth and velocity. From these comparisons the hydrodynamic force can be calculated as drag only, even in the case of a breaking wave front. The contribution from inertia relative to drag depends on the size of the structure. For larger structures the contributions may be important in steep waves. To study the initiation of motion (of sediments) under unsteady flow, waves of various parameter values were passed over a gravel covered bed. The initiation of motion starts before the peak of the wave, and is given by Shield's relation if the friction slope is applied. No dependence upon the wave gradient was found. A relation was established which gives the critical shear stress if the friction slope is estimated by the bottom slope. 65 refs., 41 figs., 10 tabs

  16. Contact force structure and force chains in 3D sheared granular systems

    Science.gov (United States)

    Mair, Karen; Jettestuen, Espen; Abe, Steffen

    2010-05-01

    Faults often exhibit accumulations of granular debris, ground up to create a layer of rock flour or fault gouge separating the rigid fault walls. Numerical simulations and laboratory experiments of sheared granular materials, suggest that applied loads are preferentially transmitted across such systems by transient force networks that carry enhanced forces. The characterisation of such features is important since their nature and persistence almost certainly influence the macroscopic mechanical stability of these systems and potentially that of natural faults. 3D numerical simulations of granular shear are a valuable investigation tool since they allow us to track individual particle motions, contact forces and their evolution during applied shear, that are difficult to view directly in laboratory experiments or natural fault zones. In characterising contact force distributions, it is important to use global structure measures that allow meaningful comparisons of granular systems having e.g. different grain size distributions, as may be expected at different stages of a fault's evolution. We therefore use a series of simple measures to characterise the structure, such as distributions and correlations of contact forces that can be mapped onto a force network percolation problem as recently proposed by Ostojic and coworkers for 2D granular systems. This allows the use of measures from percolation theory to both define and characterise the force networks. We demonstrate the application of this method to 3D simulations of a sheared granular material. Importantly, we then compare our measure of the contact force structure with macroscopic frictional behaviour measured at the boundaries of our model to determine the influence of the force networks on macroscopic mechanical stability.

  17. Differential magnetic force microscope imaging.

    Science.gov (United States)

    Wang, Ying; Wang, Zuobin; Liu, Jinyun; Hou, Liwei

    2015-01-01

    This paper presents a method for differential magnetic force microscope imaging based on a two-pass scanning procedure to extract differential magnetic forces and eliminate or significantly reduce background forces with reversed tip magnetization. In the work, the difference of two scanned images with reversed tip magnetization was used to express the local magnetic forces. The magnetic sample was first scanned with a low lift distance between the MFM tip and the sample surface, and the magnetization direction of the probe was then changed after the first scan to perform the second scan. The differential magnetic force image was obtained through the subtraction of the two images from the two scans. The theoretical and experimental results have shown that the proposed method for differential magnetic force microscope imaging is able to reduce the effect of background or environment interference forces, and offers an improved image contrast and signal to noise ratio (SNR). © Wiley Periodicals, Inc.

  18. Bilateral movements increase sustained extensor force in the paretic arm.

    Science.gov (United States)

    Kang, Nyeonju; Cauraugh, James H

    2018-04-01

    Muscle weakness in the extensors poststroke is a common motor impairment. Unfortunately, research is unclear on whether bilateral movements increase extensor force production in the paretic arm. This study investigated sustained force production while stroke individuals maximally extended their wrist and fingers on their paretic arm. Specifically, we determined isometric force production in three conditions: (a) unilateral paretic arm, (b) unilateral nonparetic arm, and (c) bilateral (both arms executing the same movement simultaneously). Seventeen chronic stroke patients produced isometric sustained force by executing wrist and fingers extension in unilateral and bilateral contraction conditions. Mean force, force variability (coefficient of variation), and signal-to-noise ratio were calculated for each contraction condition. Analysis of two-way (Arm × Type of Condition: 2 × 2; Paretic or Nonparetic Arm × Unilateral or Bilateral Conditions) within-subjects ANOVAs revealed that the bilateral condition increased sustained force in the paretic arm, but reduced sustained force in the nonparetic arm. Further, although the paretic arm exhibited more force variability and less signal-to-noise ratio than the nonparetic arm during a unilateral condition, there were no differences when participants simultaneously executed isometric contractions with both arms. Our unique findings indicate that bilateral contractions transiently increased extensor force in the paretic arm. Implications for Rehabilitation Bilateral movements increased isometric wrsit extensor force in paretic arms and redcued force in nonparetic arms versus unilateral movements. Both paretic and nonparetic arms produced similar force variability and signal-to-noise ratio during bilateral movements. Increased sustained force in the paretic arm during the bilateral condition indicates that rehabilitation protocols based on bilateral movements may be beneficial for functional recovery.

  19. Effects of nonmagnetic interparticle forces on magnetorheological fluids

    International Nuclear Information System (INIS)

    Klingenberg, D J; Olk, C H; Golden, M A; Ulicny, J C

    2010-01-01

    Effects of nonmagnetic interparticle forces on the on- and off-state behavior of magnetorheological fluids are investigated experimentally and with particle-level simulations. Suspensions of iron particles in an aliphatic oil are modified by surface-active species. The modifications significantly alter the off-state properties, but have little impact on the field-induced stresses. Simulations show similar behavior. Off-state rheological properties are strongly influenced by van der Waals forces and modifications of the short-range repulsive forces. Field-induced stresses are less sensitive to the nonmagnetic forces.

  20. Mechanism of force mode dip-pen nanolithography

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Haijun, E-mail: yanghaijun@sinap.ac.cn, E-mail: swguo@sjtu.edu.cn, E-mail: wanghuabin@cigit.ac.cn [Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240 (China); Interfacial Water Division and Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, CAS, Shanghai 201800 (China); Xie, Hui; Rong, Weibin; Sun, Lining [State Key Laboratory of Robotics and Systems, Harbin Institute of Technology, Harbin 150080 (China); Wu, Haixia; Guo, Shouwu, E-mail: yanghaijun@sinap.ac.cn, E-mail: swguo@sjtu.edu.cn, E-mail: wanghuabin@cigit.ac.cn [Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240 (China); Wang, Huabin, E-mail: yanghaijun@sinap.ac.cn, E-mail: swguo@sjtu.edu.cn, E-mail: wanghuabin@cigit.ac.cn [Centre for Tetrahertz Research, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714 (China)

    2014-05-07

    In this work, the underlying mechanism of the force mode dip-pen nanolithography (FMDPN) is investigated in depth by analyzing force curves, tapping mode deflection signals, and “Z-scan” voltage variations during the FMDPN. The operation parameters including the relative “trigger threshold” and “surface delay” parameters are vital to control the loading force and dwell time for ink deposition during FMDPN. A model is also developed to simulate the interactions between the atomic force microscope tip and soft substrate during FMDPN, and verified by its good performance in fitting our experimental data.

  1. Effects of nonmagnetic interparticle forces on magnetorheological fluids

    International Nuclear Information System (INIS)

    Klingenberg, D J; Olk, C K; Golden, M A; Ulicny, J C

    2009-01-01

    Effects of nonmagnetic interparticle forces on the on- and off-state behavior of MR fluids are investigated experimentally and with particle-level simulations. Suspensions of iron particles in an aliphatic oil are modified by surface-active species. The modifications significantly alter the off-state properties, but have little impact on the field-induced stresses. Simulations show similar behavior. Off-state rheological properties are strongly influenced by van der Waals forces and modifications of the short-range repulsive forces. Field-induced stresses are less sensitive to the nonmagnetic forces.

  2. Chin force in violin playing.

    Science.gov (United States)

    Obata, Satoshi; Kinoshita, Hiroshi

    2012-06-01

    Force generated between the left mandible of violinists and the chinrest of the violin was examined using a force-sensing chinrest developed in this study. A strain-gauge force sensor was built, and it was fixed between the violin's top plate and a chin cup. Fifteen professional/amateur violinists held the violin statically, played musical scales with different sound properties and sounding techniques, as well as an excerpt from a Max Bruch concerto. Peak and mean forces were evaluated for each task. In a separate experiment, lateral movement of the lower teeth due to different levels of voluntary chin force exertion was measured. Static holding forces observed were 15 and 22 N with and without the help of the left hand, respectively. Peak force increased from 16 N at soft dynamics to 20 N at strong dynamics during scales. The force further increased to 29 N with the use of vibrato technique and 35 N during shifts. Tempo and hand position did not affect the force. Playing a Bruch concerto induced a mean peak force of 52 N, ranging from 31 to 82 N among the violinists. The developed force-sensing chinrest could accurately record the generated chin force. Typical chin force to stabilize the violin during ordinary musical performance was less than 30 N, but it could momentarily exceed 50 N when technically demanding musical pieces were performed. The lateral shift of the mandible was fairly small (<0.4 mm) even with high chin-force exertion, possibly due to clenching of the molars.

  3. [Galileo and centrifugal force].

    Science.gov (United States)

    Vilain, Christiane

    This work intends to focus on Galileo's study of what is now called "centrifugal force," within the framework of the Second Day of his Dialogo written in 1632, rather than on the previously published commentaries on the topic. Galileo proposes three geometrical demonstrations in order to prove that gravity will always overcome centrifugalforce, and that the potential rotation of the Earth, whatever its speed, cannot in any case project objects beyond it. Each of these demonstrations must consequently contain an error and it has seemed to us that the first one had not been understood up until now. Our analysis offers an opportunity to return to Galileo's geometrical representation of dynamical questions; actually, we get an insight into the sophistication of Galileo's practices more than into his mistakes. Our second point, concerning the historiography of the problem, shows an evolution from anachronic critics to more contextual considerations, in the course of the second half of the twentieth century.

  4. Force Limit System

    Science.gov (United States)

    Pawlik, Ralph; Krause, David; Bremenour, Frank

    2011-01-01

    The Force Limit System (FLS) was developed to protect test specimens from inadvertent overload. The load limit value is fully adjustable by the operator and works independently of the test system control as a mechanical (non-electrical) device. When a test specimen is loaded via an electromechanical or hydraulic test system, a chance of an overload condition exists. An overload applied to a specimen could result in irreparable damage to the specimen and/or fixturing. The FLS restricts the maximum load that an actuator can apply to a test specimen. When testing limited-run test articles or using very expensive fixtures, the use of such a device is highly recommended. Test setups typically use electronic peak protection, which can be the source of overload due to malfunctioning components or the inability to react quickly enough to load spikes. The FLS works independently of the electronic overload protection.

  5. The resistible force

    International Nuclear Information System (INIS)

    Baeschlin, D.L.

    1980-01-01

    Many people of today have an oppositional attitude towards the continual loss of sense of existence which manifests itself in 'the great refusal'. They also behave in an anti-authoritarian manner towards their first father Marx. They realize that it is ourselves who have to search and find. The protest groups of the most different origin have come into being as 'the sand in the wheels' of a seemingly irresistable force. They have formed themselves beyond the 'Left' and the 'Right'. Nuclear energy is the instrument which acts as a gear for their opposition, which establishes it and which provides the basis for their self-concept. It is the symbol where the conflict between living standard and living quality breaks open. In essential, however, the protest is growing towards supporting an effective administration of all goods of our world. (orig./HP) [de

  6. Direct measurements of intermolecular forces by chemical force microscopy

    Science.gov (United States)

    Vezenov, Dmitri Vitalievich

    1999-12-01

    Detailed description of intermolecular forces is key to understanding a wide range of phenomena from molecular recognition to materials failure. The unique features of atomic force microscopy (AFM) to make point contact force measurements with ultra high sensitivity and to generate spatial maps of surface topography and forces have been extended to include measurements between well-defined organic molecular groups. Chemical modification of AFM probes with self-assembled monolayers (SAMs) was used to make them sensitive to specific molecular interactions. This novel chemical force microscopy (CFM) technique was used to probe forces between different molecular groups in a range of environments (vacuum, organic liquids and aqueous solutions); measure surface energetics on a nanometer scale; determine pK values of the surface acid and base groups; measure forces to stretch and unbind a short synthetic DNA duplex and map the spatial distribution of specific functional groups and their ionization state. Studies of adhesion forces demonstrated the important contribution of hydrogen bonding to interactions between simple organic functionalities. The chemical identity of the tip and substrate surfaces as well as the medium had a dramatic effect on adhesion between model monolayers. A direct correlation between surface free energy and adhesion forces was established. The adhesion between epoxy polymer and model mixed SAMs varied with the amount of hydrogen bonding component in the monolayers. A consistent interpretation of CFM measurements in polar solvents was provided by contact mechanics models and intermolecular force components theory. Forces between tips and surfaces functionalized with SAMs terminating in acid or base groups depended on their ionization state. A novel method of force titration was introduced for highly local characterization of the pK's of surface functional groups. The pH-dependent changes in friction forces were exploited to map spatially the

  7. The Effect of Improving the Logistics Pipeline on Supply Support of Aerospace Expeditionary Forces

    National Research Council Canada - National Science Library

    Martinez, Steven

    2001-01-01

    .... If so, the Air Force should be able to trim its wartime stocks of aircraft spares. This thesis investigated the effect of improving the logistics pipeline on the size and cost of Air Force mobility readiness spares packages (MRSPs...

  8. Energy profile of nanobody–GFP complex under force

    International Nuclear Information System (INIS)

    Klamecka, Kamila; Severin, Philip M; Milles, Lukas F; Gaub, Hermann E; Leonhardt, Heinrich

    2015-01-01

    Nanobodies (Nbs)—the smallest known fully functional and naturally occuring antigen-binding fragments—have attracted a lot of attention throughout the last two decades. Exploring their potential beyond the current use requires more detailed characterization of their binding forces as those cannot be directly derived from the binding affinities. Here we used atomic force microscope to measure rupture force of the Nb–green fluorescent protein (GFP) complex in various pulling geometries and derived the energy profile characterizing the interaction along the direction of the pulling force. We found that—despite identical epitopes—the Nb binds stronger (41–56 pN) to enhanced GFP than to wild-type GFP (28–45 pN). Measured forces make the Nb–GFP pair a potent reference for investigating molecular forces in living systems both in and ex vivo. (paper)

  9. Energy profile of nanobody-GFP complex under force

    Science.gov (United States)

    Klamecka, Kamila; Severin, Philip M.; Milles, Lukas F.; Gaub, Hermann E.; Leonhardt, Heinrich

    2015-10-01

    Nanobodies (Nbs)—the smallest known fully functional and naturally occuring antigen-binding fragments—have attracted a lot of attention throughout the last two decades. Exploring their potential beyond the current use requires more detailed characterization of their binding forces as those cannot be directly derived from the binding affinities. Here we used atomic force microscope to measure rupture force of the Nb-green fluorescent protein (GFP) complex in various pulling geometries and derived the energy profile characterizing the interaction along the direction of the pulling force. We found that—despite identical epitopes—the Nb binds stronger (41-56 pN) to enhanced GFP than to wild-type GFP (28-45 pN). Measured forces make the Nb-GFP pair a potent reference for investigating molecular forces in living systems both in and ex vivo.

  10. Energy profile of nanobody-GFP complex under force.

    Science.gov (United States)

    Klamecka, Kamila; Severin, Philip M; Milles, Lukas F; Gaub, Hermann E; Leonhardt, Heinrich

    2015-09-10

    Nanobodies (Nbs)-the smallest known fully functional and naturally occuring antigen-binding fragments-have attracted a lot of attention throughout the last two decades. Exploring their potential beyond the current use requires more detailed characterization of their binding forces as those cannot be directly derived from the binding affinities. Here we used atomic force microscope to measure rupture force of the Nb-green fluorescent protein (GFP) complex in various pulling geometries and derived the energy profile characterizing the interaction along the direction of the pulling force. We found that-despite identical epitopes-the Nb binds stronger (41-56 pN) to enhanced GFP than to wild-type GFP (28-45 pN). Measured forces make the Nb-GFP pair a potent reference for investigating molecular forces in living systems both in and ex vivo.

  11. Origins of hydrodynamic forces on centrifugal pump impellers

    Science.gov (United States)

    Adkins, Douglas R.; Brennen, Christopher E.

    1987-01-01

    Hydrodynamic interactions that occur between a centrifugal pump impeller and volute are experimentally and theoretically investigated. The theoretical analysis considers the inability of the blades to perfectly guide the flow through the impeller, and also includes a quasi-one dimensional treatment of the flow in the volute. The disturbance at the impeller discharge and the resulting forces are determined by the theoretical model. The model is then extended to obtain the hydrodynamic force perturbations that are caused by the impeller whirling eccentrically in the volute. Under many operating conditions, these force perturbations were found to be destablizing. Comparisons are made between the theoretical model and the experimental measurements of pressure distributions and radial forces on the impeller. The theoretical model yields fairly accurate predictions of the radial forces caused by the flow through the impeller. However, it was found that the pressure acting on the front shroud of the impeller has a substantial effect on the destablizing hydrodynamic forces.

  12. Corrected direct force balance method for atomic force microscopy lateral force calibration

    International Nuclear Information System (INIS)

    Asay, David B.; Hsiao, Erik; Kim, Seong H.

    2009-01-01

    This paper reports corrections and improvements of the previously reported direct force balance method (DFBM) developed for lateral calibration of atomic force microscopy. The DFBM method employs the lateral force signal obtained during a force-distance measurement on a sloped surface and relates this signal to the applied load and the slope of the surface to determine the lateral calibration factor. In the original publication [Rev. Sci. Instrum. 77, 043903 (2006)], the tip-substrate contact was assumed to be pinned at the point of contact, i.e., no slip along the slope. In control experiments, the tip was found to slide along the slope during force-distance curve measurement. This paper presents the correct force balance for lateral force calibration.

  13. Task Force on Innovation in Dental Hygiene Curricula.

    Science.gov (United States)

    Bader, James; And Others

    1989-01-01

    The background, origins, functions, and recommendations of the American Association of Dental Schools' task force investigating improvement of access to dental hygiene training programs and of curriculum and program design are presented. (MSE)

  14. Depletion interaction measured by colloidal probe atomic force microscopy

    NARCIS (Netherlands)

    Wijting, W.K.; Knoben, W.; Besseling, N.A.M.; Leermakers, F.A.M.; Cohen Stuart, M.A.

    2004-01-01

    We investigated the depletion interaction between stearylated silica surfaces in cyclohexane in the presence of dissolved polydimethylsiloxane by means of colloidal probe atomic force microscopy. We found that the range of the depletion interaction decreases with increasing concentration.

  15. Automated force controller for amplitude modulation atomic force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Miyagi, Atsushi, E-mail: atsushi.miyagi@inserm.fr, E-mail: simon.scheuring@inserm.fr; Scheuring, Simon, E-mail: atsushi.miyagi@inserm.fr, E-mail: simon.scheuring@inserm.fr [U1006 INSERM, Université Aix-Marseille, Parc Scientifique et Technologique de Luminy, 163 Avenue de Luminy, 13009 Marseille (France)

    2016-05-15

    Atomic Force Microscopy (AFM) is widely used in physics, chemistry, and biology to analyze the topography of a sample at nanometer resolution. Controlling precisely the force applied by the AFM tip to the sample is a prerequisite for faithful and reproducible imaging. In amplitude modulation (oscillating) mode AFM, the applied force depends on the free and the setpoint amplitudes of the cantilever oscillation. Therefore, for keeping the applied force constant, not only the setpoint amplitude but also the free amplitude must be kept constant. While the AFM user defines the setpoint amplitude, the free amplitude is typically subject to uncontrollable drift, and hence, unfortunately, the real applied force is permanently drifting during an experiment. This is particularly harmful in biological sciences where increased force destroys the soft biological matter. Here, we have developed a strategy and an electronic circuit that analyzes permanently the free amplitude of oscillation and readjusts the excitation to maintain the free amplitude constant. As a consequence, the real applied force is permanently and automatically controlled with picoNewton precision. With this circuit associated to a high-speed AFM, we illustrate the power of the development through imaging over long-duration and at various forces. The development is applicable for all AFMs and will widen the applicability of AFM to a larger range of samples and to a larger range of (non-specialist) users. Furthermore, from controlled force imaging experiments, the interaction strength between biomolecules can be analyzed.

  16. Influence of permittivity on gradient force exerted on Mie spheres.

    Science.gov (United States)

    Chen, Jun; Li, Kaikai; Li, Xiao

    2018-04-01

    In optical trapping, whether a particle could be stably trapped into the focus region greatly depends on the strength of the gradient force. Individual theoretical study on gradient force exerted on a Mie particle is rare because the mathematical separation of the gradient force and the scattering force in the Mie regime is difficult. Based on the recent forces separation work by Du et al. [Sci. Rep.7, 18042 (2017)SRCEC32045-232210.1038/s41598-017-17874-1], we investigate the influence of permittivity (an important macroscopic physical quantity) on the gradient force exerted on a Mie particle by cooperating numerical calculation using fast Fourier transform and analytical analysis using multipole expansion. It is revealed that gradient forces exerted on small spheres are mainly determined by the electric dipole moment except for certain permittivity with which the real part of polarizability of the electric dipole approaches zero, and gradient forces exerted on larger spheres are complex because of the superposition of the multipole moments. The classification of permittivity corresponding to different varying tendencies of gradient forces exerted on small spheres or larger Mie particles are illustrated. Absorption of particles favors the trapping of small spheres by gradient force, while it is bad for the trapping of larger particles. Moreover, the absolute values of the maximal gradient forces exerted on larger Mie particles decline greatly versus the varied imaginary part of permittivity. This work provides elaborate investigation on the different varying tendencies of gradient forces versus permittivity, which favors more accurate and free optical trapping.

  17. Onset patterns in a simple model of localized parametric forcing.

    Science.gov (United States)

    Porter, J; Tinao, I; Laverón-Simavilla, A; Rodríguez, J

    2013-10-01

    We investigate pattern selection at onset in a parametrically and inhomogeneously forced partial differential equation obtained by generalizing Mathieu's equation to include spatial interactions. No separation of scales is assumed. The proposed model is directly relevant to the case of parametrically forced surface waves, such as cross-waves, excited by the horizontal vibration of a fluid, where the forcing is localized to a finite region near the endwall or wavemaker. The availability of analytical solutions in the limit of piecewise constant forcing allows us investigate in detail the dependence of selected eigenfunctions on spatial detuning, forcing width, damping, boundary conditions, and container size. A wide range of onset patterns are located and described, many of which are rotated, modulated, or both, and deviate far from simple crosswise oriented standing waves. The linear selection mechanisms governing this multiplicity of potential onset patterns are discussed.

  18. Analysis of DNA interactions using single-molecule force spectroscopy.

    Science.gov (United States)

    Ritzefeld, Markus; Walhorn, Volker; Anselmetti, Dario; Sewald, Norbert

    2013-06-01

    Protein-DNA interactions are involved in many biochemical pathways and determine the fate of the corresponding cell. Qualitative and quantitative investigations on these recognition and binding processes are of key importance for an improved understanding of biochemical processes and also for systems biology. This review article focusses on atomic force microscopy (AFM)-based single-molecule force spectroscopy and its application to the quantification of forces and binding mechanisms that lead to the formation of protein-DNA complexes. AFM and dynamic force spectroscopy are exciting tools that allow for quantitative analysis of biomolecular interactions. Besides an overview on the method and the most important immobilization approaches, the physical basics of the data evaluation is described. Recent applications of AFM-based force spectroscopy to investigate DNA intercalation, complexes involving DNA aptamers and peptide- and protein-DNA interactions are given.

  19. Variability of a "force signature" during windmill softball pitching and relationship between discrete force variables and pitch velocity.

    Science.gov (United States)

    Nimphius, Sophia; McGuigan, Michael R; Suchomel, Timothy J; Newton, Robert U

    2016-06-01

    This study assessed reliability of discrete ground reaction force (GRF) variables over multiple pitching trials, investigated the relationships between discrete GRF variables and pitch velocity (PV) and assessed the variability of the "force signature" or continuous force-time curve during the pitching motion of windmill softball pitchers. Intraclass correlation coefficient (ICC) for all discrete variables was high (0.86-0.99) while the coefficient of variance (CV) was low (1.4-5.2%). Two discrete variables were significantly correlated to PV; second vertical peak force (r(5)=0.81, p=0.03) and time between peak forces (r(5)=-0.79; p=0.03). High ICCs and low CVs support the reliability of discrete GRF and PV variables over multiple trials and significant correlations indicate there is a relationship between the ability to produce force and the timing of this force production with PV. The mean of all pitchers' curve-average standard deviation of their continuous force-time curves demonstrated low variability (CV=4.4%) indicating a repeatable and identifiable "force signature" pattern during this motion. As such, the continuous force-time curve in addition to discrete GRF variables should be examined in future research as a potential method to monitor or explain changes in pitching performance. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Scratch direction and threshold force in nanoscale scratching using atomic force microscopes

    Energy Technology Data Exchange (ETDEWEB)

    Tseng, Ampere A., E-mail: ampere.tseng@asu.edu [Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan (China); Kuo, Chung-Feng Jeffrey; Jou, Shyankay [Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan (China); Nishimura, Shinya; Shirakashi, Jun-ichi [Department of Electrical and Electronic Engineering, Tokyo University of Agriculture and Technology, Tokyo 184-8588 (Japan)

    2011-09-01

    The nanoscaled tip in an AFM (atomic force microscope) has become an effective scratching tool for material removing in nanofabrication. In this article, the characteristics of using a diamond-coated pyramidal tip to scratch Ni-Fe thin film surfaces was experimentally investigated with the focus on the evaluation of the influence of the scratch or scan direction on the final shape of the scratched geometry as well as the applied scratch force. Results indicated that both the scratched profile and the scratch force were greatly affected by the scratch direction. It has been found that, to minimize the formation of protuberances along the groove sides and to have a better control of the scratched geometry, the tip face should be perpendicular to the scratching direction, which is also known as orthogonal cutting condition. To demonstrate the present findings, three groove patterns have been scratched with the tip face perpendicular to the scratching direction and very little amount of protuberances was observed. The threshold scratch force was also predicted based on the Hertz contact theory. Without considering the surface friction and adhesive forces between the tip and substrate, the threshold force predicted was twice smaller than the measurement value. Finally, recommendations for technical improvement and research focuses are provided.

  1. Scratch direction and threshold force in nanoscale scratching using atomic force microscopes

    International Nuclear Information System (INIS)

    Tseng, Ampere A.; Kuo, Chung-Feng Jeffrey; Jou, Shyankay; Nishimura, Shinya; Shirakashi, Jun-ichi

    2011-01-01

    The nanoscaled tip in an AFM (atomic force microscope) has become an effective scratching tool for material removing in nanofabrication. In this article, the characteristics of using a diamond-coated pyramidal tip to scratch Ni-Fe thin film surfaces was experimentally investigated with the focus on the evaluation of the influence of the scratch or scan direction on the final shape of the scratched geometry as well as the applied scratch force. Results indicated that both the scratched profile and the scratch force were greatly affected by the scratch direction. It has been found that, to minimize the formation of protuberances along the groove sides and to have a better control of the scratched geometry, the tip face should be perpendicular to the scratching direction, which is also known as orthogonal cutting condition. To demonstrate the present findings, three groove patterns have been scratched with the tip face perpendicular to the scratching direction and very little amount of protuberances was observed. The threshold scratch force was also predicted based on the Hertz contact theory. Without considering the surface friction and adhesive forces between the tip and substrate, the threshold force predicted was twice smaller than the measurement value. Finally, recommendations for technical improvement and research focuses are provided.

  2. Quadriceps force and anterior tibial force occur obviously later than vertical ground reaction force: a simulation study

    OpenAIRE

    Ueno, Ryo; Ishida, Tomoya; Yamanaka, Masanori; Taniguchi, Shohei; Ikuta, Ryohei; Samukawa, Mina; Saito, Hiroshi; Tohyama, Harukazu

    2017-01-01

    Background: Although it is well known that quadriceps force generates anterior tibial force, it has been unclear whether quadriceps force causes great anterior tibial force during the early phase of a landing task. The purpose of the present study was to examine whether the quadriceps force induced great anterior tibial force during the early phase of a landing task. Methods: Fourteen young, healthy, female subjects performed a single-leg landing task. Muscle force and anterior tibial force w...

  3. Irrigation as an Historical Climate Forcing

    Science.gov (United States)

    Cook, Benjamin I.; Shukla, Sonali P.; Puma, Michael J.; Nazarenko, Larissa S.

    2014-01-01

    Irrigation is the single largest anthropogenic water use, a modification of the land surface that significantly affects surface energy budgets, the water cycle, and climate. Irrigation, however, is typically not included in standard historical general circulation model (GCM) simulations along with other anthropogenic and natural forcings. To investigate the importance of irrigation as an anthropogenic climate forcing, we conduct two 5-member ensemble GCM experiments. Both are setup identical to the historical forced (anthropogenic plus natural) scenario used in version 5 of the Coupled Model Intercomparison Project, but in one experiment we also add water to the land surface using a dataset of historically estimated irrigation rates. Irrigation has a negligible effect on the global average radiative balance at the top of the atmosphere, but causes significant cooling of global average surface air temperatures over land and dampens regional warming trends. This cooling is regionally focused and is especially strong in Western North America, the Mediterranean, the Middle East, and Asia. Irrigation enhances cloud cover and precipitation in these same regions, except for summer in parts of Monsoon Asia, where irrigation causes a reduction in monsoon season precipitation. Irrigation cools the surface, reducing upward fluxes of longwave radiation (increasing net longwave), and increases cloud cover, enhancing shortwave reflection (reducing net shortwave). The relative magnitude of these two processes causes regional increases (northern India) or decreases (Central Asia, China) in energy availability at the surface and top of the atmosphere. Despite these changes in net radiation, however, climate responses are due primarily to larger magnitude shifts in the Bowen ratio from sensible to latent heating. Irrigation impacts on temperature, precipitation, and other climate variables are regionally significant, even while other anthropogenic forcings (anthropogenic aerosols

  4. MEMS Bragg grating force sensor

    DEFF Research Database (Denmark)

    Reck, Kasper; Thomsen, Erik Vilain; Hansen, Ole

    2011-01-01

    We present modeling, design, fabrication and characterization of a new type of all-optical frequency modulated MEMS force sensor based on a mechanically amplified double clamped waveguide beam structure with integrated Bragg grating. The sensor is ideally suited for force measurements in harsh...... environments and for remote and distributed sensing and has a measured sensitivity of -14 nm/N, which is several times higher than what is obtained in conventional fiber Bragg grating force sensors. © 2011 Optical Society of America....

  5. Gravity as Quantum Entanglement Force

    OpenAIRE

    Lee, Jae-Weon; Kim, Hyeong-Chan; Lee, Jungjai

    2010-01-01

    We conjecture that the total quantum entanglement of matter and vacuum in the universe tends to increase with time, like entropy, and that an effective force is associated with this tendency. We also suggest that gravity and dark energy are types of quantum entanglement forces, similar to Verlinde's entropic force, and give holographic dark energy with an equation of state comparable to current observational data. This connection between quantum entanglement and gravity could give some new in...

  6. Localization and force analysis at the single virus particle level using atomic force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Chih-Hao [Institute of Applied Mechanics, Nation Taiwan University, Roosevelt Road, Taipei 10617, Taiwan (China); Horng, Jim-Tong [Department of Biochemistry, Chang Gung University, 259 Wen-Hwa First Road, Kweishan, Taoyuan 333, Taiwan (China); Chang, Jeng-Shian [Institute of Applied Mechanics, Nation Taiwan University, Roosevelt Road, Taipei 10617, Taiwan (China); Hsieh, Chung-Fan [Graduate Institute of Biomedical Sciences, Chang Gung University, Kweishan, Taoyuan 333, Taiwan (China); Tseng, You-Chen [Institute of Applied Mechanics, Nation Taiwan University, Roosevelt Road, Taipei 10617, Taiwan (China); Lin, Shiming, E-mail: til@ntu.edu.tw [Institute of Applied Mechanics, Nation Taiwan University, Roosevelt Road, Taipei 10617, Taiwan (China); Center for Optoelectronic Biomedicine, College of Medicine, Nation Taiwan University, 1-1 Jen-Ai Road, Taipei 10051, Taiwan (China)

    2012-01-06

    Highlights: Black-Right-Pointing-Pointer Localization of single virus particle. Black-Right-Pointing-Pointer Force measurements. Black-Right-Pointing-Pointer Force mapping. -- Abstract: Atomic force microscopy (AFM) is a vital instrument in nanobiotechnology. In this study, we developed a method that enables AFM to simultaneously measure specific unbinding force and map the viral glycoprotein at the single virus particle level. The average diameter of virus particles from AFM images and the specificity between the viral surface antigen and antibody probe were integrated to design a three-stage method that sets the measuring area to a single virus particle before obtaining the force measurements, where the influenza virus was used as the object of measurements. Based on the purposed method and performed analysis, several findings can be derived from the results. The mean unbinding force of a single virus particle can be quantified, and no significant difference exists in this value among virus particles. Furthermore, the repeatability of the proposed method is demonstrated. The force mapping images reveal that the distributions of surface viral antigens recognized by antibody probe were dispersed on the whole surface of individual virus particles under the proposed method and experimental criteria; meanwhile, the binding probabilities are similar among particles. This approach can be easily applied to most AFM systems without specific components or configurations. These results help understand the force-based analysis at the single virus particle level, and therefore, can reinforce the capability of AFM to investigate a specific type of viral surface protein and its distributions.

  7. Macroeconomic Forces and Stock Returns in Vietnam

    OpenAIRE

    Phan, Van Hang

    2008-01-01

    Capital market development, especially the appearance of Vietnamese equity market recently has a strategic importance in the economic growth and structural reform process of Vietnam (Chun et al, 2003). This dissertation focuses on the impacts of macroeconomic forces on stock market returns in Vietnamese stock market which has not been investigated in detail before, and thereby to contribute further literature on this new emerging stock market. Specifically, the research will intensively inves...

  8. Report of the Task Force on radiopharmaceuticals

    International Nuclear Information System (INIS)

    Lacker, D.K.; Porter, B.J.; Watkins, G.

    1975-01-01

    The procedures for evaluation of IND and NDA applications were reviewed by FDA and the state members of the Task Force believe that there is significant progress being made toward expeditious handling of these items. Progress toward publication of the final rule on radiopharmaceuticals has reduced the need for state regulatory activity in investigational aspects of radiopharmaceutical research to the point that the original concept for the training is no longer valid

  9. Classical description of dynamical many-body systems with central forces, spin-orbit forces and spin-spin forces

    International Nuclear Information System (INIS)

    Goepfert, A.

    1994-01-01

    This thesis develops a new model, and related numerical methods, to describe classical time-dependent many-body systems interacting through central forces, spin-orbit forces and spin-spin forces. The model is based on two-particle interactions. The two-body forces consist of attractive and repulsive parts. In this model the investigated multi-particle systems are self-bound. Also the total potential of the whole ensemble is derived from the two-particle potential and is not imposed 'from outside'. Each particle has the three degrees of freedom of its centre-of-mass motion and the spin degree of freedom. The model allows for the particles to be either charged or uncharged. Furthermore, each particle has an angular momentum, an intrinsic spin, and a magnetic dipole moment. Through the electromagnetic forces between these charges and moments there arise dynamical couplings between them. The internal interactions between the charges and moments are well described by electromagnetic coupling mechanisms. In fact, compared to conventional classical molecular dynamics calculations in van der Waals clusters, which have no spin degrees of freedom, or for Heisenberg spin Systems, which have no orbital degrees of freedom, the model presented here contains both types of degrees of freedom with a highly non-trivial coupling. The model allows to study the fundamental effects resulting from the dynamical coupling of the spin and the orbital-motion sub-systems. In particular, the dynamics of the particle mass points show a behaviour basically different from the one of particles in a potential with only central forces. Furthermore, a special type of quenching procedure was invented, which tends to drive the multi-particle Systems into states with highly periodic, non-ergodic behaviour. Application of the model to cluster simulations has provided evidence that the model can also be used to investigate items like solid-to-liquid phase transitions (melting), isomerism and specific heat

  10. Capillary force on a tilted cylinder: Atomic Force Microscope (AFM) measurements.

    Science.gov (United States)

    Kosgodagan Acharige, Sébastien; Laurent, Justine; Steinberger, Audrey

    2017-11-01

    The capillary force in situations where the liquid meniscus is asymmetric, such as the one around a tilted object, has been hitherto barely investigated even though these situations are very common in practice. In particular, the capillary force exerted on a tilted object may depend on the dipping angle i. We investigate experimentally the capillary force that applies on a tilted cylinder as a function of its dipping angle i, using a home-built tilting Atomic Force Microscope (AFM) with custom made probes. A micrometric-size rod is glued at the end of an AFM cantilever of known stiffness, whose deflection is measured when the cylindrical probe is dipped in and retracted from reference liquids. We show that a torque correction is necessary to understand the measured deflection. We give the explicit expression of this correction as a function of the probes' geometrical parameters, so that its magnitude can be readily evaluated. The results are compatible with a vertical capillary force varying as 1/cosi, in agreement with a recent theoretical prediction. Finally, we discuss the accuracy of the method for measuring the surface tension times the cosine of the contact angle of the liquid on the probe. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Forces of nature

    CERN Document Server

    AUTHOR|(CDS)2072602

    2016-01-01

    A breathtaking and beautiful exploration of our planet. This groundbreaking book, which accompanies the new BBC1 TV series, provides the deepest answers to the simplest questions. 'Why is the sky blue?' 'Why is the Earth round?' 'Why is every snowflake unique?' To answer these and many other questions, Professor Brian Cox will reveal some of the most extraordinary phenomena and events on Earth and in the Universe and beyond. From the immensity of Earth's globe to all the world's myriad snowflakes, the forces of nature shape everything we see. Pushed to extremes, the results are astonishing. From the realm of auroras to the heart of our planet, the ingredients that make everything on Earth connect each one of us in an eternal cycle of life. Brian will reveal why Earth is the most colourful world we know, exploring the white light of the sun as it travels through the darkness of space until it hits Earth's atmosphere where it begins a new journey, splitting into a rainbow of colours. From the great plains of th...

  12. J-integral analysis of heterogeneous mismatched girth welds in clamped single-edge notched tension specimens

    International Nuclear Information System (INIS)

    Hertelé, Stijn; De Waele, Wim; Verstraete, Matthias; Denys, Rudi; O'Dowd, Noel

    2014-01-01

    Flaw assessment procedures require a quantification of crack driving force, and such procedures are generally based on the assumption of weld homogeneity. However, welds generally have a heterogeneous microstructure, which will influence the crack driving force. This paper describes a stress-based methodology to assess complex heterogeneous welds using a J-based approach. Clamped single-edge notched tension specimens, representative of girth weld flaws, are analyzed and the influence of weld heterogeneity on crack driving force has been determined. The use of a modified limit load for heterogeneous welds is proposed, suitable for implementation in a ‘homogenized’ J-integral estimation scheme. It follows from an explicit modification of an existing solution for centre cracked tension specimens. The proposed solution provides a good estimate of crack driving force and any errors in the approximation may be accounted for by means of a small safety factor on load bearing capacity. - Highlights: • We present a crack driving force estimation procedure for heterogeneous welds. • The procedure is based on a ‘homogenized’ version of the EPRI equation. • Complex welds are translated into equivalent idealized mismatched welds. • The procedure is validated for clamped SE(T) specimens. • A mismatch limit load for clamped SE(T) specimens is developed

  13. Blocking of Brute Force Attack

    OpenAIRE

    M.Venkata Krishna Reddy

    2012-01-01

    A common threat Web developers face is a password-guessing attack known as a brute-force attack. A brute-force attack is an attempt to discover a password by systematically trying every possible combination of letters, numbers, and symbols until you discover the one correct combination that works. If your Web site requires user authentication, you are a good target for a brute-force attack. An attacker can always discover a password through a brute-force attack, but the downside is that it co...

  14. Force As A Momentum Current

    International Nuclear Information System (INIS)

    Munera, Hector A.

    2010-01-01

    Advantages of a neo-Cartesian approach to classical mechanics are noted. If conservation of linear momentum is the fundamental principle, Newton's three laws become theorems. A minor paradox in static Newtonian mechanics is identified, and solved by reinterpreting force as a current of momentum. Contact force plays the role of a mere midwife in the exchange of momentum; however, force cannot be eliminated from physics because it provides the numerical value for momentum current. In this sense, in a neo-Cartesian formulation of mechanics the concept of force becomes strengthened rather than weakened.

  15. Curvature force and dark energy

    International Nuclear Information System (INIS)

    Balakin, Alexander B; Pavon, Diego; Schwarz, Dominik J; Zimdahl, Winfried

    2003-01-01

    A curvature self-interaction of the cosmic gas is shown to mimic a cosmological constant or other forms of dark energy, such as a rolling tachyon condensate or a Chaplygin gas. Any given Hubble rate and deceleration parameter can be traced back to the action of an effective curvature force on the gas particles. This force self-consistently reacts back on the cosmological dynamics. The links between an imperfect fluid description, a kinetic description with effective antifriction forces and curvature forces, which represent a non-minimal coupling of gravity to matter, are established

  16. Magnetic Resonance Force Microscopy System

    Data.gov (United States)

    Federal Laboratory Consortium — The Magnetic Resonance Force Microscopy (MRFM) system, developed by ARL, is the world's most sensitive nuclear magnetic resonance (NMR) spectroscopic analysis tool,...

  17. Force generation by titin folding.

    Science.gov (United States)

    Mártonfalvi, Zsolt; Bianco, Pasquale; Naftz, Katalin; Ferenczy, György G; Kellermayer, Miklós

    2017-07-01

    Titin is a giant protein that provides elasticity to muscle. As the sarcomere is stretched, titin extends hierarchically according to the mechanics of its segments. Whether titin's globular domains unfold during this process and how such unfolded domains might contribute to muscle contractility are strongly debated. To explore the force-dependent folding mechanisms, here we manipulated skeletal-muscle titin molecules with high-resolution optical tweezers. In force-clamp mode, after quenching the force (force trace contained rapid fluctuations and a gradual increase of average force, indicating that titin can develop force via dynamic transitions between its structural states en route to the native conformation. In 4 M urea, which destabilizes H-bonds hence the consolidated native domain structure, the net force increase disappeared but the fluctuations persisted. Thus, whereas net force generation is caused by the ensemble folding of the elastically-coupled domains, force fluctuations arise due to a dynamic equilibrium between unfolded and molten-globule states. Monte-Carlo simulations incorporating a compact molten-globule intermediate in the folding landscape recovered all features of our nanomechanics results. The ensemble molten-globule dynamics delivers significant added contractility that may assist sarcomere mechanics, and it may reduce the dissipative energy loss associated with titin unfolding/refolding during muscle contraction/relaxation cycles. © 2017 The Protein Society.

  18. Transforming Norwegian Special Operation Forces

    National Research Council Canada - National Science Library

    Robertsen, Tom A

    2006-01-01

    This paper explores the transformation of Norwegian Special Operation Forces (NORSOF), raising the hypothesis that its current organizational structure is inconsistent with its future roles and missions...

  19. Forces on Centrifugal Pump Impellers

    OpenAIRE

    Jery, Belgacem; Brennen, Christopher E.; Caughey, Thomas K.; Acosta, Allan

    1985-01-01

    Forces are exerted on a centrifugal pump impeller, due to the asymmetry of the flow caused by the volute of diffuser, and to the motion of the center of the impeller whenever the shaft whirls. Recent work in the measurement of these forces as a function of the whirl speed to shaft speed ratio, and the influence of the volute, is reviewed. These forces may be decomposed into a steady force, a static stiffness matrix, a damping matrix and an inertia matrix. It is shown that for centrifugal p...

  20. Role of attractive forces in tapping tip force microscopy

    DEFF Research Database (Denmark)

    Kyhle, Anders; Sørensen, Alexis Hammer; Bohr, Jakob

    1997-01-01

    We present experimental and numerical results demonstrating the drastic influence of attractive forces on the behaviour of the atomic force microscope when operated in the resonant tapping tip mode in an ambient environment. It is often assumed that tapping is related to repulsive interaction...

  1. Surface forces studied with colloidal probe atomic force microscopy

    NARCIS (Netherlands)

    Giesbers, M.

    2001-01-01

    Forces between surfaces are a determining factor for the performance of natural as well as synthetic colloidal systems, and play a crucial role in industrial production processes. Measuring these forces is a scientific and experimental challenge and over the years several techniques have

  2. Measuring Forces between Oxide Surfaces Using the Atomic Force Microscope

    DEFF Research Database (Denmark)

    Pedersen, Henrik Guldberg; Høj, Jakob Weiland

    1996-01-01

    The interactions between colloidal particles play a major role in processing of ceramics, especially in casting processes. With the Atomic Force Microscope (AFM) it is possible to measure the inter-action force between a small oxide particle (a few micron) and a surface as function of surface...

  3. Force balancing in mammographic compression

    International Nuclear Information System (INIS)

    Branderhorst, W.; Groot, J. E. de; Lier, M. G. J. T. B. van; Grimbergen, C. A.; Neeter, L. M. F. H.; Heeten, G. J. den; Neeleman, C.

    2016-01-01

    Purpose: In mammography, the height of the image receptor is adjusted to the patient before compressing the breast. An inadequate height setting can result in an imbalance between the forces applied by the image receptor and the paddle, causing the clamped breast to be pushed up or down relative to the body during compression. This leads to unnecessary stretching of the skin and other tissues around the breast, which can make the imaging procedure more painful for the patient. The goal of this study was to implement a method to measure and minimize the force imbalance, and to assess its feasibility as an objective and reproducible method of setting the image receptor height. Methods: A trial was conducted consisting of 13 craniocaudal mammographic compressions on a silicone breast phantom, each with the image receptor positioned at a different height. The image receptor height was varied over a range of 12 cm. In each compression, the force exerted by the compression paddle was increased up to 140 N in steps of 10 N. In addition to the paddle force, the authors measured the force exerted by the image receptor and the reaction force exerted on the patient body by the ground. The trial was repeated 8 times, with the phantom remounted at a slightly different orientation and position between the trials. Results: For a given paddle force, the obtained results showed that there is always exactly one image receptor height that leads to a balance of the forces on the breast. For the breast phantom, deviating from this specific height increased the force imbalance by 9.4 ± 1.9 N/cm (6.7%) for 140 N paddle force, and by 7.1 ± 1.6 N/cm (17.8%) for 40 N paddle force. The results also show that in situations where the force exerted by the image receptor is not measured, the craniocaudal force imbalance can still be determined by positioning the patient on a weighing scale and observing the changes in displayed weight during the procedure. Conclusions: In mammographic breast

  4. Towards unification of the four fundamental forces

    International Nuclear Information System (INIS)

    Sivaram, C.

    1987-01-01

    An account of the principles involved and the progress made in understanding of four fundamental forces of nature, namely, gravitational force, electromagnetic force, electroweak force and electrostrong force is given. The attempts being made to unify these forces are also described. (M.G.B.)

  5. Glenohumeral contact force during flat and topspin tennis forehand drives.

    Science.gov (United States)

    Blache, Yoann; Creveaux, Thomas; Dumas, Raphaël; Chèze, Laurence; Rogowski, Isabelle

    2017-03-01

    The primary role of the shoulder joint in tennis forehand drive is at the expense of the loadings undergone by this joint. Nevertheless, few studies investigated glenohumeral (GH) contact forces during forehand drives. The aim of this study was to investigate GH compressive and shearing forces during the flat and topspin forehand drives in advanced tennis players. 3D kinematics of flat and topspin forehand drives of 11 advanced tennis players were recorded. The Delft Shoulder and Elbow musculoskeletal model was implemented to assess the magnitude and orientation of GH contact forces during the forehand drives. The results showed no differences in magnitude and orientation of GH contact forces between the flat and topspin forehand drives. The estimated maximal GH contact force during the forward swing phase was 3573 ± 1383 N, which was on average 1.25 times greater than during the follow-through phase, and 5.8 times greater than during the backswing phase. Regardless the phase of the forehand drive, GH contact forces pointed towards the anterior-superior part of the glenoid therefore standing for shearing forces. Knowledge of GH contact forces during real sport tasks performed at high velocity may improve the understanding of various sport-specific adaptations and causative factors for shoulder problems.

  6. Random forcing of geostrophic motion in rotating stratified turbulence

    Science.gov (United States)

    Waite, Michael L.

    2017-12-01

    Random forcing of geostrophic motion is a common approach in idealized simulations of rotating stratified turbulence. Such forcing represents the injection of energy into large-scale balanced motion, and the resulting breakdown of quasi-geostrophic turbulence into inertia-gravity waves and stratified turbulence can shed light on the turbulent cascade processes of the atmospheric mesoscale. White noise forcing is commonly employed, which excites all frequencies equally, including frequencies much higher than the natural frequencies of large-scale vortices. In this paper, the effects of these high frequencies in the forcing are investigated. Geostrophic motion is randomly forced with red noise over a range of decorrelation time scales τ, from a few time steps to twice the large-scale vortex time scale. It is found that short τ (i.e., nearly white noise) results in about 46% more gravity wave energy than longer τ, despite the fact that waves are not directly forced. We argue that this effect is due to wave-vortex interactions, through which the high frequencies in the forcing are able to excite waves at their natural frequencies. It is concluded that white noise forcing should be avoided, even if it is only applied to the geostrophic motion, when a careful investigation of spontaneous wave generation is needed.

  7. Thermodynamic forces in coarse-grained simulations

    Science.gov (United States)

    Noid, William

    Atomically detailed molecular dynamics simulations have profoundly advanced our understanding of the structure and interactions in soft condensed phases. Nevertheless, despite dramatic advances in the methodology and resources for simulating atomically detailed models, low-resolution coarse-grained (CG) models play a central and rapidly growing role in science. CG models not only empower researchers to investigate phenomena beyond the scope of atomically detailed simulations, but also to precisely tailor models for specific phenomena. However, in contrast to atomically detailed simulations, which evolve on a potential energy surface, CG simulations should evolve on a free energy surface. Therefore, the forces in CG models should reflect the thermodynamic information that has been eliminated from the CG configuration space. As a consequence of these thermodynamic forces, CG models often demonstrate limited transferability and, moreover, rarely provide an accurate description of both structural and thermodynamic properties. In this talk, I will present a framework that clarifies the origin and impact of these thermodynamic forces. Additionally, I will present computational methods for quantifying these forces and incorporating their effects into CG MD simulations. As time allows, I will demonstrate applications of this framework for liquids, polymers, and interfaces. We gratefully acknowledge the support of the National Science Foundation via CHE 1565631.

  8. Anticipatory synergy adjustments reflect individual performance of feedforward force control.

    Science.gov (United States)

    Togo, Shunta; Imamizu, Hiroshi

    2016-10-06

    We grasp and dexterously manipulate an object through multi-digit synergy. In the framework of the uncontrolled manifold (UCM) hypothesis, multi-digit synergy is defined as the coordinated control mechanism of fingers to stabilize variable important for task success, e.g., total force. Previous studies reported anticipatory synergy adjustments (ASAs) that correspond to a drop of the synergy index before a quick change of the total force. The present study compared ASA's properties with individual performances of feedforward force control to investigate a relationship of those. Subjects performed a total finger force production task that consisted of a phase in which subjects tracked target line with visual information and a phase in which subjects produced total force pulse without visual information. We quantified their multi-digit synergy through UCM analysis and observed significant ASAs before producing total force pulse. The time of the ASA initiation and the magnitude of the drop of the synergy index were significantly correlated with the error of force pulse, but not with the tracking error. Almost all subjects showed a significant increase of the variance that affected the total force. Our study directly showed that ASA reflects the individual performance of feedforward force control independently of target-tracking performance and suggests that the multi-digit synergy was weakened to adjust the multi-digit movements based on a prediction error so as to reduce the future error. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  9. Neuromuscular rate of force development deficit in Parkinson disease.

    Science.gov (United States)

    Hammond, Kelley G; Pfeiffer, Ronald F; LeDoux, Mark S; Schilling, Brian K

    2017-06-01

    Bradykinesia and reduced neuromuscular force exist in Parkinson disease. The interpolated twitch technique has been used to evaluate central versus peripheral manifestations of neuromuscular strength in healthy, aging, and athletic populations, as well as moderate to advanced Parkinson disease, but this method has not been used in mild Parkinson disease. This study aimed to evaluate quadriceps femoris rate of force development and quantify potential central and peripheral activation deficits in individuals with Parkinson disease. Nine persons with mild Parkinson Disease (Hoehn & Yahr≤2, Unified Parkinson Disease Rating Scale total score=mean 19.1 (SD 5.0)) and eight age-matched controls were recruited in a cross-sectional investigation. Quadriceps femoris voluntary and stimulated maximal force and rate of force development were evaluated using the interpolated twitch technique. Thirteen participants satisfactorily completed the protocol. Individuals with early Parkinson disease (n=7) had significantly slower voluntary rate of force development (p=0.008; d=1.97) and rate of force development ratio (p=0.004; d=2.18) than controls (n=6). No significant differences were found between groups for all other variables. Persons with mild-to-moderate Parkinson disease display disparities in rate of force development, even without deficits in maximal force. The inability to produce force at a rate comparable to controls is likely a downstream effect of central dysfunction of the motor pathway in Parkinson disease. Copyright © 2017. Published by Elsevier Ltd.

  10. Analysis of sitting forces on stationary chairs for daily activities.

    Science.gov (United States)

    Hu, Lingling; Tackett, Bob; Tor, Onder; Zhang, Jilei

    2016-04-01

    No literature related to the study of sitting forces on chairs sat on by people who weighed over 136 kg was found. The Business Institutional Furniture Manufactures Association needs force data for development of performance test standards to test chairs for users who weigh up to 181 kg. 20 participants who weighed from 136 to 186 kg completed 6 tasks on an instrumented chair in the sequence of sitting down, remaining seated and rising. Effects of sitting motion, armrest use and seat cushion thickness on vertical sitting forces and centre-of-force were investigated. Results indicated hard sitting down yielded the highest sitting force of 213% in terms of participants' body weights. Armrest use affected sitting forces of normal sitting down, but not of rising and hard sitting down. Cushion thickness affected sitting forces of normal and hard sitting down and shifting, but not of rising, static seating or stretching backward situations. Practitioner Summary: Results of the sitting force and centre-of-force data obtained for this research can help furniture manufacturers develop new product performance test standards for creating reliable engineering design and manufacturing quality and durable products to meet a niche market need.

  11. Compressive Force Spectroscopy: From Living Cells to Single Proteins.

    Science.gov (United States)

    Wang, Jiabin; Liu, Meijun; Shen, Yi; Sun, Jielin; Shao, Zhifeng; Czajkowsky, Daniel Mark

    2018-03-23

    One of the most successful applications of atomic force microscopy (AFM) in biology involves monitoring the effect of force on single biological molecules, often referred to as force spectroscopy. Such studies generally entail the application of pulling forces of different magnitudes and velocities upon individual molecules to resolve individualistic unfolding/separation pathways and the quantification of the force-dependent rate constants. However, a less recognized variation of this method, the application of compressive force, actually pre-dates many of these "tensile" force spectroscopic studies. Further, beyond being limited to the study of single molecules, these compressive force spectroscopic investigations have spanned samples as large as living cells to smaller, multi-molecular complexes such as viruses down to single protein molecules. Correspondingly, these studies have enabled the detailed characterization of individual cell states, subtle differences between seemingly identical viral structures, as well as the quantification of rate constants of functionally important, structural transitions in single proteins. Here, we briefly review some of the recent achievements that have been obtained with compressive force spectroscopy using AFM and highlight exciting areas of its future development.

  12. Adhesive forces at bimetallic interfaces

    International Nuclear Information System (INIS)

    Das, M.P.; Nafari, N.; Ziesche, P.; Kaschner, H.R.

    1987-03-01

    Force concepts in condensed systems have progressed significantly in recent years. In the context of bimetallic interfaces we consider the Pauli-Hellman-Feynman theorem, use it to check the variational calculations of interfacial energies and estimate the force constants. (author). 13 refs, 2 figs, 2 tabs

  13. Force.com enterprise architecture

    CERN Document Server

    Fawcett, Andrew

    2014-01-01

    This book is for advanced Force.com developers and architects who need to understand the Salesforce platform from the perspective of enterprise-level requirements. You should have an existing understanding of Apex and Visualforce. Those familiar with other enterprise software ecosystems will also find this book ideal as they adopt Force.com.

  14. Forcing absoluteness and regularity properties

    NARCIS (Netherlands)

    Ikegami, D.

    2010-01-01

    For a large natural class of forcing notions, we prove general equivalence theorems between forcing absoluteness statements, regularity properties, and transcendence properties over L and the core model K. We use our results to answer open questions from set theory of the reals.

  15. Societal Forces That ERODE Creativity

    Science.gov (United States)

    Sternberg, Robert; Kaufman, James C.

    2018-01-01

    Background/Context: Creativity is an indispensable force in intellectual, social, cultural, and economic development. Yet societal forces conspire to erode it. Educators have despaired for many years over how schools often fail to encourage creativity, but society as a whole is just as guilty. But how do schools and society fail to encourage, or…

  16. Seven Important Labor Force Trends.

    Science.gov (United States)

    Bailey, John A.

    1982-01-01

    Presents statistics on the changing human resources mix in the labor force, which vocational counselors should be aware of. Trends include higher percentages of women working, and older men and married men leaving the work force. One result is an increasing number of persons are able to retire earlier. (JAC)

  17. Handbook of Molecular Force Spectroscopy

    CERN Document Server

    Noy, Aleksandr

    2008-01-01

    "...Noy's Handbook of Molecular Force Spectroscopy is both a timely and useful summary of fundamental aspects of molecular force spectroscopy, and I believe it would make a worthwhile addition to any good scientific library. New research groups that are entering this field would be well advisedto study this handbook in detail before venturing into the exciting and challenging world of molecular force spectroscopy." Matthew F. Paige, University of Saskatchewan, Journal of the American Chemical Society Modern materials science and biophysics are increasingly focused on studying and controlling intermolecular interactions on the single-molecule level. Molecular force spectroscopy was developed in the past decade as the result of several unprecedented advances in the capabilities of modern scientific instrumentation, and defines a number of techniques that use mechanical force measurements to study interactions between single molecules and molecular assemblies in chemical and biological systems. Examples of these...

  18. A discussion about simplified methodologies for failure assessment of nuclear reactor components

    International Nuclear Information System (INIS)

    Cruz, J.R.B.; Andrade, A.H.P. de; Landes, J.D.

    1996-01-01

    Failure of nuclear reactor components like pressure vessels and piping must be avoided for all phases of reactor operation. Especially severe loading conditions come from postulated accident scenarios during which the integrity of the component is required. The use of Fracture Mechanics concepts to investigate the mechanical behavior of flawed structures in the non-linear regime is a complex subject due to the fact that the crack driving force (expressed in terms of J or CTOD) is not /only a function of the cracked geometry, but depends also on the plastic flow properties of the material. Since the numerical solutions by the finite element method are expensive and time consuming, the existence of simplified engineering procedures is of great relevance. These allow a ready identification of the main parameters affecting the crack driving force, and permit a fast and simple evaluation of the structural integrity of the cracked component. This paper presents an overview of the major simplified ductile fracture methodologies that have been proposed in the literature trying to point out their similarities, strong points and negative aspects. Once the best characteristics of each method are identified, they could then be combined to develop a single methodology, one that would be both easy to use and capable of making accurate failure predictions

  19. Investigative psychology

    OpenAIRE

    Canter, David V.

    2010-01-01

    The domain of Investigative Psychology covers all aspects of psychology that are relevant to the conduct of criminal or civil investigations. Its focus is on the ways in which criminal activities may be examined and understood in order for the detection of crime to be effective and legal proceedings to be appropriate. As such Investigative Psychology is concerned with psychological input to the full range of issues that relate to the management, investigation and prosecution of crime

  20. Brown algal morphogenesis: Atomic Force Microscopy as a tool to study the role of mechanical forces

    Directory of Open Access Journals (Sweden)

    Benoit eTesson

    2014-09-01

    Full Text Available Over the last few years, a growing interest has been directed toward the use of macroalgae as a source of energy, food and molecules for the cosmetic and pharmaceutical industries. Besides this, macroalgal development remains poorly understood compared to other multicellular organisms. Brown algae (Phaeophyceae form a monophyletic lineage of usually large multicellular algae which evolved independently from land plants. In their environment, they are subjected to strong mechanical forces (current, waves and tide, in response to which they modify rapidly and reversibly their morphology. Because of their specific cellular features (cell wall composition, cytoskeleton organization, deciphering how they cope with these forces might help discover new control mechanisms of cell wall softening and cellulose synthesis. Despite the current scarcity in knowledge on brown algal cell wall dynamics and protein composition, we will illustrate, in the light of methods adapted to Ectocarpus siliculosus, to what extent atomic force microscopy can contribute to advance this field of investigation.

  1. Probing living bacterial adhesion by single cell force spectroscopy using atomic force microscopy

    DEFF Research Database (Denmark)

    Zeng, Guanghong; Ogaki, Ryosuke; Regina, Viduthalai R.

    be considered. We have therefore developed a simple and versatile method to make single-cell bacterial probes for measuring single cell adhesion with atomic force microscopy (AFM).[1] A single-cell probe was readily made by picking up a bacterial cell from a glass surface using a tipless AFM cantilever coated...... random immobilization is obtained by submerging the cantilever in a bacterial suspension. The reported method provides a general platform for investigating single cell interactions of bacteria with different surfaces and other cells by AFM force spectroscopy, thus improving our understanding....... The strain-dependent susceptibility to bacterial colonization on conventional PLL-g-PEG illustrates how bacterial diversity challenges development of “universal” antifouling coatings, and AFM single-cell force spectroscopy was proven to be a powerful tool to provide insights into the molecular mechanisms...

  2. Force transmissibility versus displacement transmissibility

    Science.gov (United States)

    Lage, Y. E.; Neves, M. M.; Maia, N. M. M.; Tcherniak, D.

    2014-10-01

    It is well-known that when a single-degree-of-freedom (sdof) system is excited by a continuous motion of the foundation, the force transmissibility, relating the force transmitted to the foundation to the applied force, equals the displacement transmissibility. Recent developments in the generalization of the transmissibility to multiple-degree-of-freedom (mdof) systems have shown that similar simple and direct relations between both types of transmissibility do not appear naturally from the definitions, as happens in the sdof case. In this paper, the authors present their studies on the conditions under which it is possible to establish a relation between force transmissibility and displacement transmissibility for mdof systems. As far as the authors are aware, such a relation is not currently found in the literature, which is justified by being based on recent developments in the transmissibility concept for mdof systems. Indeed, it does not appear naturally, but the authors observed that the needed link is present when the displacement transmissibility is obtained between the same coordinates where the applied and reaction forces are considered in the force transmissibility case; this implies that the boundary conditions are not exactly the same and instead follow some rules. This work presents a formal derivation of the explicit relation between the force and displacement transmissibilities for mdof systems, and discusses its potential and limitations. The authors show that it is possible to obtain the displacement transmissibility from measured forces, and the force transmissibility from measured displacements, opening new perspectives, for example, in the identification of applied or transmitted forces. With this novel relation, it becomes possible, for example, to estimate the force transmissibility matrix with the structure off its supports, in free boundary conditions, and without measuring the forces. As far as force identification is concerned, this

  3. Functionalization of gold and nanocrystalline diamond atomic force microscope tips for single molecule force spectroscopy

    Science.gov (United States)

    Drew, Michael E.

    The atomic force microscope (AFM) has fueled interest in nanotechnology because of its ability to image surfaces at the nanometer level and act as a molecular force sensor. Functionalization of the surface of an AFM tip surface in a stable, controlled manner expands the capabilities of the AFM and enables additional applications in the fields of single molecule force spectroscopy and nanolithography. Two AFM tip functionalizations are described: the assembly of tripodal molecular tips onto gold AFM tips and the photochemical attachment of terminal alkenes to nanocrystalline diamond (NCD) AFM tips. Two separate tripodal molecules with different linker lengths and a monopodal molecule terminated with biotin were synthesized to attach to a gold AFM tip for single molecule force spectroscopy. The immobilization of these molecules was examined by contact angle measurements, spectroscopic ellipsometry, infrared, and near edge x-ray absorption fine structure (NEXAFS) spectroscopy. All three molecules displayed rupture forces that agreed with previously reported values for the biotin--avidin rupture. The tripodal molecular tip displayed narrower distribution in their force histograms than the monopodal molecular tip. The performance of the tripodal molecular tip was compared to the monopodal molecular tip in single molecule force spectroscopy studies. Over repeated measurements, the distribution of forces for the monopodal molecular tip shifted to lower forces, whereas the distribution for the tripodal molecular tip remained constant throughout. Loading rate dependence and control experiments further indicated that the rupture forces of the tripod molecular tips were specific to the biotin--NeutrAvidin interaction. The second functionalization method used the photochemical attachment of undecylenic acid to NCD AFM tips. The photochemical attachment of undecylenic acid to hydrogen-terminated NCD wafer surfaces was investigated by contact angle measurements, x

  4. Nanonewton force measurement using a modified Michelson interferometer

    International Nuclear Information System (INIS)

    Tahviliyan, Masoud; Charsooghi, Mohammad A; Akhlaghi, Ehsan A; Taghi Tavassoly, Mohammad

    2017-01-01

    In this paper, we introduce a new method to measure forces in the nanonewton range. The method is based on modification of a Michelson interferometer in which the rigid mirrors are replaced with two thin rod-like mirrors. One of the rod-like mirrors is fixed at both ends and the other has one free end. As the mirror with free end deflects in response to an applied force the spatial interference pattern is changed. Analysis of the interference fringes provides a readout of the rod deflection and thereby the applied force. The device is calibrated by applying known forces to the mirror with a free end and measuring the resulting displacement. Two different methods, mechanical and electrostatic, are used for calibration. The precision of the measurements and the propagation of the calibration uncertainty are investigated. The results show that this optical method is a good candidate for detecting small forces in the nanonewton range. (paper)

  5. Levitation force relaxation under reloading in a HTS Maglev system

    International Nuclear Information System (INIS)

    He Qingyong; Wang Jiasu; Wang Suyu; Wang Jiansi; Dong Hao; Wang Yuxin; Shao Senhao

    2009-01-01

    The loading capacity of the high-temperature superconducting (HTS) Maglev vehicle is an important parameter in the practical application. It is closely related to the levitation force of the HTS bulk. Many papers reported that the levitation force showed the relaxation characteristic. Because different loads cause different levitation gaps and different applied magnetic fields, the levitation force relaxations under the different loads are not the same. In terms of cylindrical YBCO bulk levitated over the permanent magnetic guideway, the relationship between the levitation force relaxation and the reloading is investigated experimentally in this paper. The decrement, the decrement rate and the relaxation rate of the levitation force are calculated, respectively. This work might be helpful for studying the loading capacity of the HTS Maglev vehicle

  6. Levitation force relaxation under reloading in a HTS Maglev system

    Energy Technology Data Exchange (ETDEWEB)

    He Qingyong [Applied Superconductivity Laboratory, M/S 152, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China)], E-mail: hedoubling@gmail.com; Wang Jiasu; Wang Suyu; Wang Jiansi; Dong Hao; Wang Yuxin; Shao Senhao [Applied Superconductivity Laboratory, M/S 152, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China)

    2009-02-01

    The loading capacity of the high-temperature superconducting (HTS) Maglev vehicle is an important parameter in the practical application. It is closely related to the levitation force of the HTS bulk. Many papers reported that the levitation force showed the relaxation characteristic. Because different loads cause different levitation gaps and different applied magnetic fields, the levitation force relaxations under the different loads are not the same. In terms of cylindrical YBCO bulk levitated over the permanent magnetic guideway, the relationship between the levitation force relaxation and the reloading is investigated experimentally in this paper. The decrement, the decrement rate and the relaxation rate of the levitation force are calculated, respectively. This work might be helpful for studying the loading capacity of the HTS Maglev vehicle.

  7. A study on forces acting on a flapping wing

    Directory of Open Access Journals (Sweden)

    Cetiner O.

    2013-04-01

    Full Text Available In order to study the forces acting on a flapping wing, an experimental investigation is performed in steady water flow. In this study, a SD7003 airfoil undergoes combined pitching and plunging motion which simulates the forward flight of small birds. The frequency of pitching motion is equal to the frequency of plunging motion and pitch leads the plunge by a phase angle of 90 degrees. The experiments are conducted at Reynolds numbers of 2500 ≤ Re ≤ 13700 and the vortex formation is recorded using the digital particle image velocimetry (DPIV technique. A prediction of thrust force and efficiency is calculated from the average wake deficit of DPIV data, the near-wake vorticity patterns and time dependent velocity vectors are determined to comment on the thrust and drag indication. Direct force measurements are attempted using a Force/Torque sensor which is capable of measuring forces and moments in three axial directions.

  8. Effects of additional inertia force on bubble breakup

    International Nuclear Information System (INIS)

    Pan Liangming; Zhang Wenzhi; Chen Deqi; Xu Jianhui; Xu Jianjun; Huang Yanping

    2011-01-01

    Through VOF two-phase flow model, the single bubble deformation and breakup in a vertical narrow channel is numerically investigated in the study based on the force balance at the process of bubble breakup. The effect of surface tension force, the additional inertia force and bubble initial shape on bubble breakup are analyzed according to the velocity variation at the break-up point and the minimum necking size when the bubble is breaking up. It is found that the surface tension force, the additional inertia force and the bubble initial shape have significant effects on the bubble breakup through the fluid injection toward to the bubble, which finally induces the onset of bubble breakup. (authors)

  9. Making Invisible Forces Visible

    DEFF Research Database (Denmark)

    Ratner, Helene Gad

    2013-01-01

    This paper investigates managerial tactics of visualisation when a need to know and manage employees' values and attitudes is expressed. Using the Danish public school as a case study, we explore how school managers use teachers' emotions to render visible presumably invisible information about...... their 'true' attitudes and values. The paper draws on theories of affect as well as actor-network theory to analyse three incidents where managers turn their interpretations of teachers' emotions into such information. These incidents suggest that the efforts to render employees' attitudes and values visible...

  10. Towards measurement of the Casimir force between parallel plates separated at sub-mircon distance

    NARCIS (Netherlands)

    Syed Nawazuddin, M.B.; Lammerink, Theodorus S.J.; Wiegerink, Remco J.; Berenschot, Johan W.; de Boer, Meint J.; Elwenspoek, Michael Curt

    2011-01-01

    Ever since its prediction, experimental investigation of the Casimir force has been of great scientific interest. Many research groups have successfully attempted quantifying the force with different device geometries; however measurement of the Casimir force between parallel plates with sub-micron

  11. All about Forces & Gravity. Physical Science for Children[TM]. Schlessinger Science Library. [Videotape].

    Science.gov (United States)

    2000

    A force is a push or a pull. In All About Forces and Gravity, kids will join our host on a parasailing adventure to investigate how forces impact and shape everything that happens in the world around us. Learn about gravity and the work of Sir Isaac Newton, the English scientists whose scientific principles forever changed the way people looked at…

  12. Some Consequences of Prompting Novice Physics Students to Construct Force Diagrams

    Science.gov (United States)

    Heckler, Andrew F.

    2010-01-01

    We conducted a series of experiments to investigate the extent to which prompting the construction of a force diagram affects student solutions to simple mechanics problems. A total of 891 university introductory physics students were given typical force and motion problems under one of the two conditions: when a force diagram was or was not…

  13. The application of force-sensing resistor sensors for measuring forces developed by the human hand.

    Science.gov (United States)

    Nikonovas, A; Harrison, A J L; Hoult, S; Sammut, D

    2004-01-01

    Most attempts to measure forces developed by the human hand have been implemented by placing force sensors on the object of interaction. Other researchers have placed sensors just on the subject's fingertips. In this paper, a system is described that measures forces over the entire hand using thin-film sensors and associated electronics. This system was developed by the authors and is able to obtain force readings from up to 60 thin-film sensors at rates of up to 400 samples/s per sensor. The sensors can be placed anywhere on the palm and/or fingers of the hand. The sensor readings, together with a video stream containing information about hand posture, are logged into a portable computer using a multiplexer, analogue-to-digital converter and software developed for the purpose. The system has been successfully used to measure forces involved in a range of everyday tasks such as driving a vehicle, lifting saucepans and hitting a golf ball. In the latter case, results are compared with those from an instrumented golf club. Future applications include the assessment of hand strength following disease, trauma or surgery, and to enable quantitative ergonomic investigations.

  14. Climate forcing by anthropogenic aerosols

    Energy Technology Data Exchange (ETDEWEB)

    Charlson, R J; Schwartz, S E; Hales, J M; Cess, R D; Coakley, Jr, J A; Hansen, J E; Hofmann, D J [University of Washington, Seattle, WA (USA). Inst. for Environmental Studies, Dept. of Atmospheric Sciences

    1992-01-24

    Although long considered to be of marginal importance to global climate change, tropospheric aerosol contributes substantially to radiative forcing, and anthropogenic sulfate aerosol in particular has imposed a major perturbation to this forcing. Both the direct scattering of short wavelength solar radiation and the modification of the shortwave reflective properties of clouds by sulfate aerosol particles increase planetary albedo, thereby exerting a cooling influence on the planet. Current climate forcing due to anthropogenic sulfate is estimated to be -1 to -2 watts per square metre, globally averaged. This perturbation is comparable in magnitude to current anthropogenic greenhouse gas forcing but opposite in sign. Thus, the aerosol forcing has likely offset global greenhouse warming to a substantial degree. However, differences in geographical and seasonal distributions of these forcings preclude any simple compensation. Aerosol effects must be taken into account in evaluating anthropogenic influences on past, current, and projected future climate and in formulating policy regarding controls on emission of greenhouse gases and sulfur dioxide. Resolution of such policy issues requires integrated research on the magnitude and geographical distribution of aerosol climate forcing and on the controlling chemical and physical processes. 73 refs., 4 figs., 2 tabs.

  15. Microtubules as mechanical force sensors.

    Science.gov (United States)

    Karafyllidis, Ioannis G; Lagoudas, Dimitris C

    2007-03-01

    Microtubules are polymers of tubulin subunits (dimers) arranged on a hexagonal lattice. Each tubulin dimer comprises two monomers, the alpha-tubulin and beta-tubulin, and can be found in two states. In the first state a mobile negative charge is located into the alpha-tubulin monomer and in the second into the beta-tubulin monomer. Each tubulin dimer is modeled as an electrical dipole coupled to its neighbors by electrostatic forces. The location of the mobile charge in each dimer depends on the location of the charges in the dimer's neighborhood. Mechanical forces that act on the microtubule affect the distances between the dimers and alter the electrostatic potential. Changes in this potential affect the mobile negative charge location in each dimer and the charge distribution in the microtubule. The net effect is that mechanical forces affect the charge distribution in microtubules. We propose to exploit this effect and use microtubules as mechanical force sensors. We model each dimer as a two-state quantum system and, following the quantum computation paradigm, we use discrete quantum random walk on the hexagonal microtubule lattice to determine the charge distribution. Different forces applied on the microtubule are modeled as different coin biases leading to different probability distributions of the quantum walker location, which are directly connected to different charge distributions. Simulation results show that there is a strong indication that microtubules can be used as mechanical force sensors and that they can also detect the force directions and magnitudes.

  16. Climate forcing by anthropogenic aerosols.

    Science.gov (United States)

    Charlson, R J; Schwartz, S E; Hales, J M; Cess, R D; Coakley, J A; Hansen, J E; Hofmann, D J

    1992-01-24

    Although long considered to be of marginal importance to global climate change, tropospheric aerosol contributes substantially to radiative forcing, and anthropogenic sulfate aerosol in particular has imposed a major perturbation to this forcing. Both the direct scattering of shortwavelength solar radiation and the modification of the shortwave reflective properties of clouds by sulfate aerosol particles increase planetary albedo, thereby exerting a cooling influence on the planet. Current climate forcing due to anthropogenic sulfate is estimated to be -1 to -2 watts per square meter, globally averaged. This perturbation is comparable in magnitude to current anthropogenic greenhouse gas forcing but opposite in sign. Thus, the aerosol forcing has likely offset global greenhouse warming to a substantial degree. However, differences in geographical and seasonal distributions of these forcings preclude any simple compensation. Aerosol effects must be taken into account in evaluating anthropogenic influences on past, current, and projected future climate and in formulating policy regarding controls on emission of greenhouse gases and sulfur dioxide. Resolution of such policy issues requires integrated research on the magnitude and geographical distribution of aerosol climate forcing and on the controlling chemical and physical processes.

  17. Contractors on the Battlefield Force Multipliers or Force Dividers?

    National Research Council Canada - National Science Library

    Nelson, Kim

    2000-01-01

    .... An increased reliance on contractor support has helped ease the burden on a heavily reduced force structure, but has left military commanders vulnerable to declaring a non-mission capable status during times of crisis...

  18. Air Force Officer Force Development, an Analysis and Future Issues

    National Research Council Canada - National Science Library

    Davidson, William T

    2004-01-01

    .... The intent is to identify any shortcomings in the construct, highlight processes requiring change, and assist the Air Force in building the road to a more robust, better educated, and visionary officer corps...

  19. Force reconstruction from tapping mode force microscopy experiments

    International Nuclear Information System (INIS)

    Payam, Amir F; Martin-Jimenez, Daniel; Garcia, Ricardo

    2015-01-01

    Fast, accurate, and robust nanomechanical measurements are intensely studied in materials science, applied physics, and molecular biology. Amplitude modulation force microscopy (tapping mode) is the most established nanoscale characterization technique of surfaces for air and liquid environments. However, its quantitative capabilities lag behind its high spatial resolution and robustness. We develop a general method to transform the observables into quantitative force measurements. The force reconstruction algorithm has been deduced on the assumption that the observables (amplitude and phase shift) are slowly varying functions of the tip–surface separation. The accuracy and applicability of the method is validated by numerical simulations and experiments. The method is valid for liquid and air environments, small and large free amplitudes, compliant and rigid materials, and conservative and non-conservative forces. (paper)

  20. Force 2025 and Beyond Strategic Force Design Analytic Model

    Science.gov (United States)

    2017-01-12

    focused thinking , functional hierarchy, task capability matching 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT U 18. NUMBER OF...describe and evaluate current organizational designs in terms of Force Employment and Force Design using the model to offer recommendations and analysis...developed to illuminate the current organizational design structure to better understand how the network of BCTs and enablers function in today’s steady